BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P39984 (401 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4PSX-B nrPDB 829 0.0 5Y1U-A nrPDB 274 4e-74 3CFV-B nrPDB 269 2e-72 3C9C-A nrPDB 266 9e-72 5WJC-A nrPDB 265 2e-71 4XYI-A nrPDB 258 4e-69 5Y88-O nrPDB 59 3e-09 6QX9-5O nrPDB 55 6e-08 5FL8-q nrPDB 51 8e-07 3JB9-L nrPDB 50 2e-06 5OQL-d nrPDB 50 2e-06 5MZH-A nrPDB 49 3e-06 6G51-g nrPDB 49 4e-06 6QX9-4B nrPDB 49 4e-06 5OQL-L nrPDB 48 9e-06 5NNZ-B nrPDB 47 2e-05 6HQA-B nrPDB 46 3e-05 5WLC-LJ nrPDB 46 4e-05 4A11-B nrPDB 45 8e-05 2PM9-A nrPDB 44 1e-04 5NZU-C nrPDB 44 1e-04 4V6W-Ag nrPDB 44 1e-04 3BG0-A nrPDB 44 1e-04 6EOJ-D nrPDB 42 5e-04 3FM0-A nrPDB 41 8e-04 2AQ5-A nrPDB 41 0.001 5WLC-LU nrPDB 41 0.001 6N9G-C nrPDB 40 0.001 5OQL-J nrPDB 40 0.002 4V8M-A7 nrPDB 40 0.002 5M25-A nrPDB 39 0.003 1VYH-C nrPDB 39 0.003 1PI6-A nrPDB 39 0.004 5Z56-q nrPDB 39 0.005 5A31-R nrPDB 39 0.006 6ID0-T nrPDB 38 0.006 4BH6-A nrPDB 38 0.007 6HHQ-h nrPDB 38 0.008 5K1B-B nrPDB 38 0.008 4BTS-AR nrPDB 38 0.009 4LG8-A nrPDB 38 0.010 4G56-B nrPDB 37 0.011 5TF2-A nrPDB 37 0.014 2H9P-A nrPDB 37 0.015 3W15-A nrPDB 37 0.019 5WYJ-BC nrPDB 36 0.031 5G04-R nrPDB 35 0.041 1NR0-A nrPDB 35 0.042 5GAN-H nrPDB 35 0.042 3JZG-A nrPDB 35 0.042 5LCW-Q nrPDB 35 0.044 4GGA-A nrPDB 35 0.048 5XYI-g nrPDB 35 0.050 6QDV-o nrPDB 35 0.054 5WLC-LO nrPDB 35 0.055 5YZG-W nrPDB 35 0.059 5I2T-A nrPDB 35 0.077 6MZM-G nrPDB 35 0.081 4N14-A nrPDB 34 0.093 6F3T-A nrPDB 34 0.11 3ACP-A nrPDB 34 0.13 4V7E-Bg nrPDB 34 0.14 5WYK-BB nrPDB 33 0.16 4L9O-A nrPDB 33 0.16 3JAP-g nrPDB 33 0.17 5FA5-B nrPDB 33 0.23 4U1E-I nrPDB 33 0.28 5BJS-A nrPDB 32 0.34 5OPT-p nrPDB 32 0.39 3ODT-A nrPDB 32 0.40 6CB1-s nrPDB 32 0.43 2HES-X nrPDB 32 0.49 6EM1-m nrPDB 32 0.70 3JRP-A nrPDB 32 0.71 4BZK-B nrPDB 32 0.71 3JB9-g nrPDB 31 0.83 6C0F-s nrPDB 31 0.85 5CXC-A nrPDB 31 0.86 4J0W-A nrPDB 31 0.91 3A22-A nrPDB 31 0.96 3JRO-A nrPDB 30 1.4 5MC9-A nrPDB 30 1.7 6ELZ-p nrPDB 30 1.8 4AEZ-A nrPDB 30 1.9 5L9T-R nrPDB 30 1.9 6EMK-B nrPDB 30 2.3 5CXB-B nrPDB 30 2.4 6GMH-W nrPDB 29 3.1 1OD4-A nrPDB 28 4.9 1IKQ-A nrPDB 28 5.2 4ON1-A nrPDB 28 5.2 3EI3-B nrPDB 28 5.9 4E5Z-B nrPDB 28 6.4 3DM0-A nrPDB 28 6.7 6CVZ-A nrPDB 28 7.0 2ERO-A nrPDB 28 7.3 5GLR-A nrPDB 28 7.7 5A9Q-0 nrPDB 28 8.9 5HQ2-K nrPDB 28 9.9 >4PSX-B nrPDB Length = 401 Score = 829 bits (2141), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/401 (99%), Positives = 400/401 (99%) Query: 1 MENQEKPLSVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELI 60 MENQEKPLSVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELI Sbjct: 1 MENQEKPLSVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELI 60 Query: 61 IGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEE 120 IGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEE Sbjct: 61 IGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEE 120 Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS 180 ITRARYMPQDPNIVATINGQGT FLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS Sbjct: 121 ITRARYMPQDPNIVATINGQGTTFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS 180 Query: 181 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRA 240 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRA Sbjct: 181 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRA 240 Query: 241 NNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNN 300 NNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNN Sbjct: 241 NNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNN 300 Query: 301 LEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL 360 LEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL Sbjct: 301 LEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL 360 Query: 361 NPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS 401 NPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS Sbjct: 361 NPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS 401 >5Y1U-A nrPDB Length = 456 Score = 274 bits (701), Expect = 4e-74, Method: Compositional matrix adjust. Identities = 151/399 (37%), Positives = 225/399 (56%), Gaps = 29/399 (7%) Query: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 ++EEY +WK N P +YD V L WPSLT QWLP + F L++GTHTS +E Sbjct: 48 INEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTS-DE 106 Query: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQS------SLPAPRSNIRITAKYEHEEEITR 123 +N+L A + LP N+D Q +A Y S + I I K HE E+ R Sbjct: 107 QNHLVIASVQLP-----NDDAQFDASH-YDSEKGEFGGFGSVSGKIEIEIKINHEGEVNR 160 Query: 124 ARYMPQDPNIVATINGQGTVFLYSRSEGLQS-----------TLKFHKDNGYALSFSTLV 172 ARYMPQ+P I+AT V ++ ++ L+ H+ GY LS++ + Sbjct: 161 ARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNL 220 Query: 173 KGRLLSGSDDHTVALWEVGSGGDPTKPV--RTWNDLHSDIINDNKWHNFNKDLFGTVSED 230 G LLS SDDHT+ LW++ + K V +T H+ ++ D WH ++ LFG+V++D Sbjct: 221 SGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADD 280 Query: 231 SLLKINDVRANNTTIDTVKC---PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEP 287 L I D R+NNT+ + N L+F+ +S +LA D V L+DLRN+K Sbjct: 281 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 340 Query: 288 LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMV 347 LH H+D + +++S H + ++ SSG+D RL +WDL +IG EQ+P+DAEDG PEL+ + Sbjct: 341 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI 400 Query: 348 HAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 H GH + ++DF NP PW++ S E+NI+QVW+ + ++ Sbjct: 401 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 439 >3CFV-B nrPDB Length = 414 Score = 269 bits (687), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 143/395 (36%), Positives = 223/395 (56%), Gaps = 21/395 (5%) Query: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 ++EEY +WK N P +YD V L WPSLTVQWLP + + L++GTHTS +E Sbjct: 19 INEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTS-DE 77 Query: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 +N+L A +++P + + ++ + + I K HE E+ RARYMPQ Sbjct: 78 QNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQ 137 Query: 130 DPNIVATINGQGTVFLYSRSEGLQS-----------TLKFHKDNGYALSFSTLVKGRLLS 178 +P+I+AT V ++ ++ L+ H+ GY LS+++ + G LLS Sbjct: 138 NPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLS 197 Query: 179 GSDDHTVALWEVGSGGDPTKPV--RTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 SDDHTV LW++ +G K V + HS ++ D WH ++ LFG+V++D L I Sbjct: 198 ASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIW 257 Query: 237 DVRANNTT-----IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 D R+N T+ +D N L+F+ +S +LA D V L+DLRN+K LH Sbjct: 258 DTRSNTTSKPSHLVDAHTAE--VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTF 315 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 H+D + + +S H + ++ SSG+D RL +WDL +IG EQ+ +DAEDG PEL+ +H GH Sbjct: 316 ESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGH 375 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 + ++DF NP PW++ S E+NI+Q+W+ + ++ Sbjct: 376 TAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 410 >3C9C-A nrPDB Length = 432 Score = 266 bits (681), Expect = 9e-72, Method: Compositional matrix adjust. Identities = 144/395 (36%), Positives = 220/395 (55%), Gaps = 21/395 (5%) Query: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 ++EEY +WK N P +YD V L WPSLT QWLP ++ + LI+GTHTS +E Sbjct: 23 INEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTS-DE 81 Query: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 +N+L A + LP E + + + + I I K HE E+ RARYMPQ Sbjct: 82 QNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQ 141 Query: 130 DPNIVATINGQGTVFLYSRSEG---------LQSTLKF--HKDNGYALSFSTLVKGRLLS 178 + ++AT V ++ ++ Q L+ H+ GY LS++ + G LLS Sbjct: 142 NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLS 201 Query: 179 GSDDHTVALWEVGSGGDPTKPVRTWNDL--HSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 SDDHT+ LW++ + + + N H+ ++ D WH ++ LFG+V++D L I Sbjct: 202 ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW 261 Query: 237 DVRANNT-----TIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 D R NNT T+D N L+F+ +S +LA D V L+DLRN+K LH Sbjct: 262 DTRNNNTSKPSHTVDAHTAE--VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 319 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 H+D + +++S H + ++ SSG+D RL +WDL +IG EQ+ +DAEDG PEL+ +H GH Sbjct: 320 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGH 379 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 + ++DF NP PW++ S E+NI+QVW+ + ++ Sbjct: 380 TAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 414 >5WJC-A nrPDB Length = 430 Score = 265 bits (678), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 145/395 (36%), Positives = 223/395 (56%), Gaps = 20/395 (5%) Query: 9 SVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGE 68 ++ EEY LWK NVP +YD V L WPSLT+QWLP + Q LI+GTHTSG Sbjct: 25 TIQEEYKLWKQNVPFLYDLVITHALEWPSLTIQWLPDKKTIPGTDYSIQRLILGTHTSGN 84 Query: 69 EENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMP 128 ++NYL+ A + LP +ED E + + I I+ K H+ ++ RARYMP Sbjct: 85 DQNYLQIASVQLPN---FDEDTTEFTPSTIRRAQATGSYTIEISQKIPHDGDVNRARYMP 141 Query: 129 QDPNIVATINGQGTVFLY--------SRSEGL-QSTLKFHKDNGYALSFSTLVKGRLLSG 179 Q P I+AT+ G +++ + E L Q+ LK H G+ L ++ + G L +G Sbjct: 142 QKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATG 201 Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDL-----HSDIINDNKWHNFNKDLFGTVSEDSLLK 234 ++D + LW+V + + + + + H+DI+ND ++H ++ L +VS+D L+ Sbjct: 202 AEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQ 261 Query: 235 INDVRAN--NTTIDTVKC-PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 I+D R N ++ + N +A + + LLA A D V L+DLRN + LH + Sbjct: 262 IHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTL 321 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 GHED V LE+S H + ++ SS +D R+ +WDL++IG EQTP+DAEDG PEL+ +H GH Sbjct: 322 EGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGH 381 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 + +++F P W+V S ++NILQ+W S + Sbjct: 382 TNRISEFSWCPNERWVVGSLADDNILQIWSPSRVI 416 >4XYI-A nrPDB Length = 430 Score = 258 bits (658), Expect = 4e-69, Method: Compositional matrix adjust. Identities = 143/394 (36%), Positives = 230/394 (58%), Gaps = 26/394 (6%) Query: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 + EEY LWK NVP +YD V L WPSLTV+W P + L Q+L++GT TSG + Sbjct: 26 IQEEYKLWKQNVPFLYDLVITEALEWPSLTVEWFPGSERSLADNSSIQKLLLGTQTSGND 85 Query: 70 ENYLKFAEINLPK--EILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYM 127 +NYL+ A + LP + L + P + ++ + I K HE ++ +AR+M Sbjct: 86 QNYLQVASVQLPTFDDDLDDLTPSKMKPANFKGDY-----GLDIVQKIHHEGDVNKARFM 140 Query: 128 PQDPNIVATI--NGQGTVF---LYSRS----EGLQSTLKFHKDNGYALSFSTLVKGRLLS 178 PQ+P+I+AT+ NG G +F LY G Q+ L+ H G+ L ++ + +G L + Sbjct: 141 PQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLGWNFIQEGTLAT 200 Query: 179 GSDDHTVALWEVGSGGDP------TKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSL 232 G++D ++ +W++ PV ++ H+ ++ND ++H ++ L +VS+D Sbjct: 201 GTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHR-HTAVVNDLQFHLQHEALLTSVSDDCT 259 Query: 233 LKINDVR--ANNTTIDTVKC-PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH 289 L+I+D R ++++ VK QP N +AF+ + LLA A D V L+DLR + + LH Sbjct: 260 LQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLH 319 Query: 290 HMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 + GHED V N+++S H + ++V+S +D R+ +WDL +IG EQT +D+EDG PEL+ +H Sbjct: 320 TLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHG 379 Query: 350 GHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 GH + V+D NP W++AS ++NILQ+W S Sbjct: 380 GHTNRVSDLSWNPNNKWVLASLADDNILQIWSPS 413 >5Y88-O nrPDB Length = 451 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 99/201 (49%), Gaps = 24/201 (11%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 ++GS+D T+ +W++ +G ++T H + D + + LF +VSED +K Sbjct: 155 FITGSNDTTMKVWDLATG-----KLKTTLAGHVMTVRDVAVSDRHPYLF-SVSEDKTVKC 208 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHE 295 D+ N D T++ H + +L+A AG DS + L+D+R + P+ + GH+ Sbjct: 209 WDLEKNQIIRDYYGHLSGVRTVSI-HPTLDLIATAGRDSVIKLWDMRT-RIPVITLVGHK 266 Query: 296 DAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSV 355 +N ++ T VD VVSS +D + +WD+ G ++ H H+ SV Sbjct: 267 GPINQVQ-CTPVDPQVVSSSTDATVRLWDVVA------------GKTMKVLTH--HKRSV 311 Query: 356 NDFDLNPQIPWLVASAEEENI 376 L+P+ + VASA ++I Sbjct: 312 RATALHPK-EFSVASACTDDI 331 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 24/117 (20%), Positives = 53/117 (45%), Gaps = 17/117 (14%) Query: 273 DSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQ 332 D+ + ++DL K ++GH V ++ S + S D + WDL++ Sbjct: 161 DTTMKVWDLATGKLKTT-LAGHVMTVRDVAVSDR-HPYLFSVSEDKTVKCWDLEK----- 213 Query: 333 TPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIV 389 ++I + GH S V ++P + L+A+A ++++++W +P++ Sbjct: 214 ---------NQIIRDYYGHLSGVRTVSIHPTLD-LIATAGRDSVIKLWDMRTRIPVI 260 >6QX9-5O nrPDB Length = 357 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 72/323 (22%), Positives = 138/323 (42%), Gaps = 56/323 (17%) Query: 93 EAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGL 152 +AG SSL AP I HE E+ ++ P + + +A+ + L++ Sbjct: 46 QAGPPRCSSLQAP-----IMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVYGDC 99 Query: 153 Q--STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI 210 +TLK H L ++T L S S D TVA+W+ +G + K ++ H+ Sbjct: 100 DNYATLKGHSGAVMELHYNT-DGSMLFSASTDKTVAVWDSETG-ERVKRLKG----HTSF 153 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHH-SSNLLAA 269 +N L T S+D +K+ D+R I T + + LA + + +S+ + + Sbjct: 154 VNSCYPARRGPQLVCTGSDDGTVKLWDIR-KKAAIQTFQ--NTYQVLAVTFNDTSDQIIS 210 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG 329 G+D+ + ++DLR K + M GH D+V L S+ ++S+ DN + +WD++ Sbjct: 211 GGIDNDIKVWDLRQNKL-TYTMRGHADSVTGLSLSSE-GSYLLSNAMDNTVRVWDVRPFA 268 Query: 330 AEQ----------------------TPDDAE-------------DGVPELIMVHA-GHRS 353 ++ +PD ++ D I+ GH Sbjct: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAG 328 Query: 354 SVNDFDLNPQIPWLVASAEEENI 376 S+N+ +P P +++++ ++ + Sbjct: 329 SINEVAFHPDEPIIISASSDKRL 351 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 46/180 (25%) Query: 148 RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLH 207 R L T++ H D+ LS S+ LLS + D+TV +W+V + V+ Sbjct: 223 RQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDNTVRVWDVRPFAPKERCVK------ 275 Query: 208 SDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLL 267 I HNF K+L ++C ++S S + Sbjct: 276 ---IFQGNVHNFEKNL------------------------LRC-------SWSPDGSK-I 300 Query: 268 AAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDLK 326 AA D +VY++D + + L+ + GH ++N + F H D +++S+ SD RL M +++ Sbjct: 301 AAGSADRFVYVWDTTS-RRILYKLPGHAGSINEVAF--HPDEPIIISASSDKRLYMGEIQ 357 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 57/121 (47%), Gaps = 17/121 (14%) Query: 261 HHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNR 319 H + + LA+AG D + L+++ + + GH AV L ++T DG ++ S+ +D Sbjct: 75 HPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNT--DGSMLFSASTDKT 132 Query: 320 LMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 + +W D+E G E + GH S VN + P LV + ++ +++ Sbjct: 133 VAVW------------DSETG--ERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178 Query: 380 W 380 W Sbjct: 179 W 179 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 55/242 (22%), Positives = 94/242 (38%), Gaps = 36/242 (14%) Query: 140 QGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKP 199 Q + L S EG KFH NG L+ S D + LW V D Sbjct: 56 QAPIMLLSGHEGEVYCCKFHP-NGSTLA----------SAGFDRLILLWNVYGDCDNYAT 104 Query: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPF-NTLA 258 ++ HS + + ++ LF + S D + + D + +K F N+ Sbjct: 105 LKG----HSGAVMELHYNTDGSMLF-SASTDKTVAVWDSETGER-VKRLKGHTSFVNSCY 158 Query: 259 FSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDN 318 + L+ D V L+D+R + ++ V + F+ D ++S G DN Sbjct: 159 PARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ--VLAVTFNDTSD-QIISGGIDN 215 Query: 319 RLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQ 378 + +WDL+Q +L GH SV L+ + +L+++A +N ++ Sbjct: 216 DIKVWDLRQ--------------NKLTYTMRGHADSVTGLSLSSEGSYLLSNA-MDNTVR 260 Query: 379 VW 380 VW Sbjct: 261 VW 262 >5FL8-q nrPDB Length = 515 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 66/263 (25%), Positives = 112/263 (42%), Gaps = 58/263 (22%) Query: 134 VATINGQGTVFLY-SRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGS 192 +A+ + GT+ ++ + S Q T+ H ++ + + +G L SGS D TV +W++ S Sbjct: 251 LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGG--QGLLYSGSHDRTVRVWDINS 308 Query: 193 GGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQ 252 G R N L S W N ++S D L+I A + T P+ Sbjct: 309 QG------RCINILKSHA----HWVNHL-----SLSTDYALRIG---AFDHTGKKPSTPE 350 Query: 253 PFNTLAFSHH---------SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEF 303 A ++ S ++ A D ++L++ +P+ M+GH+ VN++ F Sbjct: 351 EAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAF 410 Query: 304 STHVDG-VVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNP 362 S DG +VS+ DN + +W D DG + I GH +SV Sbjct: 411 SP--DGRYIVSASFDNSIKLW------------DGRDG--KFISTFRGHVASVY------ 448 Query: 363 QIPW-----LVASAEEENILQVW 380 Q+ W L+ S ++ L+VW Sbjct: 449 QVAWSSDCRLLVSCSKDTTLKVW 471 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 36/183 (19%), Positives = 83/183 (45%), Gaps = 16/183 (8%) Query: 154 STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIIND 213 S + H +F+ R+++G+ D+T +W+ D P+ T H + + Sbjct: 137 SAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDC----DTQTPMHTLKG-HYNWVLC 191 Query: 214 NKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNT-LAF------SHHSSNL 266 W + + ++ T S D+ +++ D ++ D ++ + T L++ S Sbjct: 192 VSW-SPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPR 250 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 LA++ D + ++D + + + MSGH ++V+ +++ G++ S D + +WD+ Sbjct: 251 LASSSKDGTIKIWDTVS-RVCQYTMSGHTNSVSCVKWGGQ--GLLYSGSHDRTVRVWDIN 307 Query: 327 QIG 329 G Sbjct: 308 SQG 310 >3JB9-L nrPDB Length = 340 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 77/157 (49%), Gaps = 12/157 (7%) Query: 177 LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 S SD H ++ W+ SG K + H+ ++N +L +VS+D +K+ Sbjct: 110 CSSSDTHLMS-WDAVSGQKIRK-----HKGHAGVVNALDVLKVGSELLTSVSDDCTMKVW 163 Query: 237 DVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHED 296 D R+ + I T++ P +A + + + G+D + ++DLRN H + GH+D Sbjct: 164 DSRSKD-CIKTIEEKYPLTAVAIAQQGTQVF-IGGIDGAIKIWDLRN-NHCSHVLKGHKD 220 Query: 297 AVNNLEFSTHVDG-VVVSSGSDNRLMMWDLKQIGAEQ 332 + +L S DG ++S+ DN + ++D+K + Q Sbjct: 221 IITSLAISK--DGSSLLSNSMDNTVRIFDVKPFASAQ 255 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 15/118 (12%) Query: 263 SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 S + A+ GMD + L+++ + ++G + A+ +L++S VV S SD LM Sbjct: 61 SGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRD-SRVVYCSSSDTHLMS 119 Query: 323 WDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 WD A G + I H GH VN D+ L+ S ++ ++VW Sbjct: 120 WD------------AVSG--QKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVW 163 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 35/66 (53%), Gaps = 11/66 (16%) Query: 264 SNLLAAAGMDSYVYLY----DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNR 319 S + A D VY++ DLR + + GHE +VN+++F H D +++S SD Sbjct: 281 SRFVGAGSSDKNVYVWSATGDLRYV------LPGHEGSVNHVDFHPHQD-IILSCSSDRT 333 Query: 320 LMMWDL 325 + + +L Sbjct: 334 IFLGEL 339 >5OQL-d nrPDB Length = 446 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 39/139 (28%), Positives = 63/139 (45%), Gaps = 20/139 (14%) Query: 200 VRTWNDLHS------------DIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDT 247 +R W+ HS D I D ++ + G+V+ D + + D+R N I T Sbjct: 177 IRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKT 236 Query: 248 V---KCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFS 304 V C N + F+ + LA A D +Y++D RN + L+ GH AV ++EFS Sbjct: 237 VLHFAC----NRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFS 292 Query: 305 THVDGVVVSSGSDNRLMMW 323 + +VS D + +W Sbjct: 293 PTGEE-LVSGSYDRTIRLW 310 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/181 (23%), Positives = 82/181 (45%), Gaps = 31/181 (17%) Query: 162 NGYALSFSTLVKGR-----LLSGSDDHTVALWEVGSGGDPTKPVRTWN-DLHSDIINDNK 215 NG+ ++ K + + SGS D V +W++ T+ TW H++I+ Sbjct: 63 NGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDL-----TTRDEETWRVAAHNNIVKGLT 117 Query: 216 WHNFNKDLFGTVSEDSLLKINDVRA---NNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM 272 + N +K L ++ +K+ D A N T I T + P+ +L+F H S+N AA+ Sbjct: 118 FTN-DKKLLSCATDG--IKLWDPYASPSNTTPIATWQEGGPYTSLSF-HRSANTFAASSG 173 Query: 273 DSYVYLYDLRNMKEPLHHMSGHE-------DAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 + ++DL H +G D + ++ F+ V+ S +D ++++DL Sbjct: 174 QGCIRIWDLE------HSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDL 227 Query: 326 K 326 + Sbjct: 228 R 228 >5MZH-A nrPDB Length = 452 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 59/258 (22%), Positives = 106/258 (41%), Gaps = 42/258 (16%) Query: 155 TLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDN 214 TL+ HK+ YA++F+ ++++GS D T LW+ +G + T ++I+ + Sbjct: 131 TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTG----QLYYTLKGHQTEIVCLS 186 Query: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS 274 N + T S D+ K+ DV +L F + +L+ D Sbjct: 187 --FNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGF-NTGGDLIVTGSFDH 243 Query: 275 YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD--------LK 326 L+D+R + +H +SGH V++ +F+ + +VVS D +WD +K Sbjct: 244 DSRLWDVRT-GQCVHVLSGHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSGRCLSVK 301 Query: 327 QIGAEQTPDDAED----------------------GVPELIMVHAGHRSSVNDFDLNPQI 364 Q ++ D A D GV + +V GH ++ NPQ Sbjct: 302 QGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLV--GHEGEISKVAFNPQG 359 Query: 365 PWLVASAEEENILQVWKC 382 L+ +A + ++W C Sbjct: 360 TRLI-TASSDKTCRLWDC 376 Score = 28.9 bits (63), Expect = 4.3, Method: Compositional matrix adjust. Identities = 20/95 (21%), Positives = 39/95 (41%), Gaps = 15/95 (15%) Query: 286 EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELI 345 E + + GH++ V + F+ +V+ D +W DA G +L Sbjct: 127 EEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLW------------DAYTG--QLY 172 Query: 346 MVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 GH++ + NPQ ++A+ +N ++W Sbjct: 173 YTLKGHQTEIVCLSFNPQ-STIIATGSMDNTAKLW 206 Score = 28.1 bits (61), Expect = 7.3, Method: Compositional matrix adjust. Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 11/132 (8%) Query: 106 RSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGL-QSTLKFHKDNGY 164 RS ++ K H +E+ + +V+ + G+ LY G+ Q TL H+ Sbjct: 293 RSGRCLSVKQGHTDEVLDVAFDAAGTKMVSA-SADGSARLYHTLTGVCQHTLVGHEGEIS 351 Query: 165 ALSFSTLVKG-RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDL 223 ++F+ +G RL++ S D T LW+ +G + H+D I + N+ D Sbjct: 352 KVAFNP--QGTRLITASSDKTCRLWDCDTG-----ECLQVLEGHTDEIFSCAF-NYEGDF 403 Query: 224 FGTVSEDSLLKI 235 T S+D+ +I Sbjct: 404 IITGSKDNTCRI 415 >6G51-g nrPDB Length = 317 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 19/220 (8%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLY--SRSE---GL-QSTLKFHKDNGYALSFST 170 H +T+ PQ P+++ + + T+ ++ +R E G+ Q L+ H + S+ Sbjct: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73 Query: 171 LVKGRL-LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 G+ LSGS D T+ LW++ +G + V D+ S + + N+ + + Sbjct: 74 --DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD-----NRQIVSGSRD 126 Query: 230 DSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN-LLAAAGMDSYVYLYDLRNMKEPL 288 ++ N + T+ + + + FS +SSN ++ + G D V +++L N K Sbjct: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 Query: 289 HHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDLKQ 327 +H+ GH +N + S DG + S G D + M+WDL + Sbjct: 187 NHI-GHTGYLNTVTVSP--DGSLCASGGKDGQAMLWDLNE 223 >6QX9-4B nrPDB Length = 522 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 68/281 (24%), Positives = 117/281 (41%), Gaps = 32/281 (11%) Query: 68 EEENYLKFAEI-----NLPKEI-------LSNEDPQEEAGEEYQSSLPAPRSNIRITAKY 115 E N LK A + +LP+ + L E P+ + Q + RS ++ Sbjct: 169 EGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQI 228 Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSE-GLQSTLKFHKDNGYALSF---STL 171 + I+ + P + ++AT G L+S + L TL+ H N A+ F ST+ Sbjct: 229 GDDRPISYCHFSP-NSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTV 287 Query: 172 VKG----RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTV 227 L S + D +V LW + D +PV H+ + WH + GT Sbjct: 288 SLDPKDVNLASCAADGSVKLWSL----DSDEPVADIEG-HTVRVARVMWHPSGR-FLGTT 341 Query: 228 SEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEP 287 D ++ D+ A + +AF H +L G+D++ ++DLR + Sbjct: 342 CYDRSWRLWDLEAQEEILHQEGHSMGVYDIAF-HQDGSLAGTGGLDAFGRVWDLRTGR-C 399 Query: 288 LHHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWDLKQ 327 + + GH + + FS +G +++GS DN +WDL+Q Sbjct: 400 IMFLEGHLKEIYGINFSP--NGYHIATGSGDNTCKVWDLRQ 438 >5OQL-L nrPDB Length = 557 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 51/180 (28%), Positives = 81/180 (45%), Gaps = 18/180 (10%) Query: 139 GQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTK 198 GQGT + + T HK + +S L+S SDD TV LW++ S DPT+ Sbjct: 129 GQGTRAV------ILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPS-NDPTR 181 Query: 199 PVRTWNDLHSDIINDNKWH--NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNT 256 H+D + + + N +L + S D +++ D RA + T K P Sbjct: 182 LFTG----HTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIED 237 Query: 257 LAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGS 316 + + LLAA+G + + + DL K PL ++ H+ V +L ++ G V SGS Sbjct: 238 VLPLPSGTTLLAASG--NAISVLDLVAAK-PLRLITNHQKTVTSLSLASQ--GRRVVSGS 292 >5NNZ-B nrPDB Length = 415 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 75/158 (47%), Gaps = 26/158 (16%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDL--HSDIINDNKWHNFNKDLFGTVSEDSLL 233 ++GS D T LW+ SG + N L H +++ ++N D T S D Sbjct: 107 FITGSYDRTCKLWDTASGEE-------LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTC 159 Query: 234 KINDVRANNTTIDTVKCPQPFN-------TLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE 286 K+ +++T KC F L+F+ S+ L+A MD+ L+D++N E Sbjct: 160 KL-------WSVETGKCYHTFRGHTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQN-GE 210 Query: 287 PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD 324 ++ + GH + +L F+T D ++ S D+ +++WD Sbjct: 211 EVYTLRGHSAEIISLSFNTSGDRIITGS-FDHTVVVWD 247 Score = 35.8 bits (81), Expect = 0.038, Method: Compositional matrix adjust. Identities = 34/148 (22%), Positives = 63/148 (42%), Gaps = 9/148 (6%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 +L+GS D T LW+ +G K V T H D I D+ + ++ L T S D +I Sbjct: 276 ILTGSMDKTCKLWDATNG----KCVATLTG-HDDEILDSCF-DYTGKLIATASADGTARI 329 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHE 295 + ++F+ ++LL + D ++D + + L + GH Sbjct: 330 FSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS-DKTARIWDAQT-GQCLQVLEGHT 387 Query: 296 DAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 D + + F+ + +V++ DN +W Sbjct: 388 DEIFSCAFN-YKGNIVITGSKDNTCRIW 414 >6HQA-B nrPDB Length = 722 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 44/153 (28%), Positives = 72/153 (47%), Gaps = 10/153 (6%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 + S D T LW D P+R + H + ++ ++H + LF T S D ++ Sbjct: 510 FATASHDQTARLWSC----DHIYPLRIFAG-HLNDVDCVEFHPNSTYLF-TGSSDKTARM 563 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH- 294 D+ + N LA S LA+AG DS V L+D+ + + M GH Sbjct: 564 WDIARGECVRVFMGHSGAINCLAVSP-DGRWLASAGEDSVVCLWDISTGRR-IKAMRGHG 621 Query: 295 EDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 ++ +L FS V+VS+G+DN + +WD+K+ Sbjct: 622 RSSIYSLAFSRE-GTVLVSTGADNSVRVWDVKK 653 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 61/260 (23%), Positives = 105/260 (40%), Gaps = 74/260 (28%) Query: 154 STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIIND 213 + LKF+ D ST+V SG D + LW + G P + + ND ++ ND Sbjct: 394 TCLKFNDD-------STMVA----SGFQDSFIKLWSID--GSPLRSLLK-NDPYNQQNND 439 Query: 214 NKWHNFNKDLFG------------------TVSEDSLLKINDVRANNTTIDTVKCPQPFN 255 ++ L G + SED +++ ++DT C Sbjct: 440 GVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRL-------WSLDTYTC----- 487 Query: 256 TLAFSHHSSNL-----------LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFS 304 +++ HSS++ A A D L+ ++ PL +GH + V+ +EF Sbjct: 488 LVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIY-PLRIFAGHLNDVDCVEF- 545 Query: 305 THVDGVVVSSGS-DNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQ 363 H + + +GS D MWD+ + E + V GH ++N ++P Sbjct: 546 -HPNSTYLFTGSSDKTARMWDIAR--------------GECVRVFMGHSGAINCLAVSPD 590 Query: 364 IPWLVASAEEENILQVWKCS 383 WL ASA E++++ +W S Sbjct: 591 GRWL-ASAGEDSVVCLWDIS 609 Score = 35.4 bits (80), Expect = 0.045, Method: Compositional matrix adjust. Identities = 23/100 (23%), Positives = 41/100 (41%), Gaps = 16/100 (16%) Query: 289 HHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVH 348 + GH AV ++FS + ++S D + +W L ++ + Sbjct: 447 RRLVGHSGAVYGVDFSPD-NRYLISCSEDKTVRLWSLDTYTC--------------LVSY 491 Query: 349 AGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPI 388 GH SSV D +P + A+A + ++W C H P+ Sbjct: 492 KGHSSSVWDVKFSPMGHYF-ATASHDQTARLWSCDHIYPL 530 >5WLC-LJ nrPDB Length = 513 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 48/206 (23%), Positives = 85/206 (41%), Gaps = 9/206 (4%) Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS 180 +T + PQ P+ A + SR+ + T KD Y+ SF + G+LL Sbjct: 42 VTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRS--DGKLLCAG 99 Query: 181 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDV-R 239 D L V +P + + N + + K+H + + T S+D + ++ D+ Sbjct: 100 D--ATGLVSVYDSYNPRTILLSIN-ASTHPTHVTKFHTQDNKILATASDDRVTRLWDISN 156 Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVN 299 A ++ TL+F + +L+A D + LYD R+ + H+ V Sbjct: 157 AYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVE 216 Query: 300 NLEFSTHVDGVVVSSGSDNRLMMWDL 325 N+ + +VS G +N +WDL Sbjct: 217 NVIAVSPTQ--IVSCGGNN-FKVWDL 239 >4A11-B nrPDB Length = 408 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 44/186 (23%), Positives = 83/186 (44%), Gaps = 25/186 (13%) Query: 172 VKGR-LLSGSDDHTVALWEVGSGGDPT----KPV----RTWNDLHSDIINDNKWHNFNKD 222 V+GR +LSG D + L+++ + + K V R D+H + +W+ + Sbjct: 54 VEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG 113 Query: 223 LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFN--TLAFSHHSS------NLLAAAGMDS 274 +F + S D LK+ D +T++ FN +SHH S L+A Sbjct: 114 MFTSSSFDKTLKVWDT-------NTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGP 166 Query: 275 YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTP 334 V L DL++ H + GH + + +S D ++ ++ +D+R+ +WD+++ Sbjct: 167 KVQLCDLKS-GSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT 225 Query: 335 DDAEDG 340 D +G Sbjct: 226 LDQHNG 231 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 33/174 (18%), Positives = 59/174 (33%), Gaps = 52/174 (29%) Query: 254 FNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG------------HEDAVNNL 301 NTL + + G D + LYDL N ++ H +V + Sbjct: 46 INTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETV 105 Query: 302 EFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD-------------------------- 335 ++ H G+ SS D L +WD + QT D Sbjct: 106 QWYPHDTGMFTSSSFDKTLKVWDTNTL---QTADVFNFEETVYSHHMSPVSTKHCLVAVG 162 Query: 336 ---------DAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 D + G I+ GHR + +P+ +++A+A ++ +++W Sbjct: 163 TRGPKVQLCDLKSGSCSHIL--QGHRQEILAVSWSPRYDYILATASADSRVKLW 214 >2PM9-A nrPDB Length = 416 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 46/213 (21%), Positives = 96/213 (45%), Gaps = 23/213 (10%) Query: 133 IVATINGQGTVFLYSRSEG---LQSTLKF--HKDNGYALSFSTLVKGRLLSGSDDHTVAL 187 I+A G++ LYS +E + S +F H + + F+ L SG ++ + + Sbjct: 81 IIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFI 140 Query: 188 WEVG------SGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRAN 241 W++ S P P ++ + + D + W+ +F + + I D++A Sbjct: 141 WDMNKCTESPSNYTPLTPGQSMSSV--DEVISLAWNQSLAHVFASAGSSNFASIWDLKAK 198 Query: 242 NTTID-TVKCP-----QPFNTLAFSHHSSNLLAAAGM---DSYVYLYDLRNMKEPLHHMS 292 I + P Q + + + +S +A A D + ++DLRN PL ++ Sbjct: 199 KEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLN 258 Query: 293 -GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD 324 GH+ + +L++ + +++SSG DN +++W+ Sbjct: 259 QGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWN 291 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/160 (26%), Positives = 69/160 (43%), Gaps = 18/160 (11%) Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDLHSDI-INDNKWHNFNKDLFGTVSEDSLLKINDV 238 S D ++ LW + D KP+ + L D ND W + NK + G + SL + Sbjct: 42 STDSSLELWSL-LAADSEKPIAS---LQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTN 97 Query: 239 RANNTTIDTVKCP---QPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE--------- 286 ANN + T+ F+ N+LA+ G + ++++D+ E Sbjct: 98 EANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLT 157 Query: 287 PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 P MS D V +L ++ + V S+GS N +WDLK Sbjct: 158 PGQSMSS-VDEVISLAWNQSLAHVFASAGSSNFASIWDLK 196 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/168 (24%), Positives = 77/168 (45%), Gaps = 21/168 (12%) Query: 225 GTV----SEDSLLKINDVRANNTT--IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYL 278 GTV S DS L++ + A ++ I +++ FN L +SH++ ++A A + + L Sbjct: 35 GTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNN-KIIAGALDNGSLEL 93 Query: 279 YDLRNMKEPLHHM---SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD 335 Y ++ M S H +V ++F+ D V+ S G++ + +WD+ + ++P Sbjct: 94 YSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNK--CTESPS 151 Query: 336 DAEDGVPELIMVHAGHRSSVND---FDLNPQIPWLVASAEEENILQVW 380 + P M SSV++ N + + ASA N +W Sbjct: 152 NYTPLTPGQSM------SSVDEVISLAWNQSLAHVFASAGSSNFASIW 193 >5NZU-C nrPDB Length = 905 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 49/212 (23%), Positives = 88/212 (41%), Gaps = 39/212 (18%) Query: 188 WEVGSGGDPTKPVRTWNDL--------HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVR 239 W V D V +N L HSD I H + T S+D L+K+ D Sbjct: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHP-TQPFILTSSDDMLIKLWDWD 129 Query: 240 ANNTTIDTVKCPQPFN-------TLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 + C Q F + + +N A+A +D + ++ L + P + Sbjct: 130 KKWS------CSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGS-SSPNFTLE 182 Query: 293 GHEDAVNNLEFSTHVDGVVVSSGSDNRLM-MWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 GHE VN +++ + D + SG+D+RL+ +WD + QT + GH Sbjct: 183 GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLE--------------GH 228 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 +V+ +P++P ++ + E+ +++W S Sbjct: 229 AQNVSCASFHPELP-IIITGSEDGTVRIWHSS 259 >4V6W-Ag nrPDB Length = 318 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 100/220 (45%), Gaps = 22/220 (10%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLY--SRSEGLQSTLKFHKDNGYALSFSTLV-- 172 H +T+ P+DP+ + + + T+ ++ +R E + G++ S +V Sbjct: 14 HNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLS 73 Query: 173 --KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTV--S 228 LSGS D T+ LW++ +G K R + D+++ F+ D V S Sbjct: 74 SDGNYALSGSWDQTLRLWDLAAG----KTTRRFEGHTKDVLS----VAFSADNRQIVSGS 125 Query: 229 EDSLLKI-NDVRANNTTIDTVKCPQPFNTLAFS-HHSSNLLAAAGMDSYVYLYDLRNMKE 286 D +K+ N + TI + + FS +HS+ ++ + G D V +++L N K Sbjct: 126 RDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKL 185 Query: 287 PLHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDL 325 +H GH +N + S DG + S G D++ ++WDL Sbjct: 186 KNNHH-GHNGYLNTVTVSP--DGSLCTSGGKDSKALLWDL 222 >3BG0-A nrPDB Length = 316 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/140 (25%), Positives = 66/140 (47%), Gaps = 14/140 (10%) Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTI--DTVKCPQPFNTLAFSH-HS 263 H D+I+D + ++ T S D +KI DVR + D P +A++H Sbjct: 12 HEDMIHDAQ-MDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY 70 Query: 264 SNLLAAAGMDSYVYLYDLRN-MKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLM- 321 N+LA+ D V ++ N E H +GH+ +VN++ ++ H G++++ GS + + Sbjct: 71 GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 Query: 322 --------MWDLKQIGAEQT 333 W++K+I T Sbjct: 131 LLTYTGEGQWEVKKINNAHT 150 Score = 35.8 bits (81), Expect = 0.030, Method: Compositional matrix adjust. Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 14/99 (14%) Query: 267 LAAAGMDSYVYLYDLRNMKEPL-HHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWD 324 LA D V ++D+RN + L + GHE V + ++ + G +++S S D ++++W Sbjct: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87 Query: 325 LKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQ 363 E+G E HAGH SSVN P Sbjct: 88 ------------EENGTWEKSHEHAGHDSSVNSVCWAPH 114 >6EOJ-D nrPDB Length = 470 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 52/265 (19%), Positives = 108/265 (40%), Gaps = 22/265 (8%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTL-KFHKDNGYALSFSTLVKGR 175 H+ +T +Y D + + + + G + ++ + + + H ++ ++FS+ + Sbjct: 134 HDSAVTTMKY-SHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS-NDSK 191 Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 ++ SDD+ + +W +G K R + H D+ WH L + S+D+L+K+ Sbjct: 192 FVTCSDDNILKIWNFSNG----KQERVLSGHHWDV-KSCDWHP-EMGLIASASKDNLVKL 245 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHE 295 D R+ N +K F NLL A D ++D+R + L + Sbjct: 246 WDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 Query: 296 DAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSV 355 D + LE+ + + + D L +DL Q E ++ + H + Sbjct: 306 DYM-TLEWHPINESMFTLACYDGSLKHFDLLQNLNE-----------PILTIPYAHDKCI 353 Query: 356 NDFDLNPQIPWLVASAEEENILQVW 380 NP + + A+A ++ ++ W Sbjct: 354 TSLSYNP-VGHIFATAAKDRTIRFW 377 >3FM0-A nrPDB Length = 345 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 35/130 (26%), Positives = 57/130 (43%), Gaps = 16/130 (12%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG---LQSTLKFHKDNGYALSFSTLVK 173 H +++ + P ++A+ + TV LY E +TL+ H+ ++L+F + Sbjct: 149 HTQDVKHVVWHPSQ-ELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207 Query: 174 GRLLSGSDDHTVALWE----------VGSGGDPT-KPVRTWNDLHSDIINDNKWHNFNKD 222 RL S SDD TV +W SG DP+ K + T + HS I D W Sbjct: 208 -RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA 266 Query: 223 LFGTVSEDSL 232 L +D++ Sbjct: 267 LATACGDDAI 276 >2AQ5-A nrPDB Length = 402 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 19/79 (24%), Positives = 43/79 (54%), Gaps = 6/79 (7%) Query: 253 PFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN------MKEPLHHMSGHEDAVNNLEFSTH 306 P +A+ H+ N++A+ D V ++++ + ++EP+ + GH V + + Sbjct: 83 PVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPT 142 Query: 307 VDGVVVSSGSDNRLMMWDL 325 V++S+G DN +++WD+ Sbjct: 143 AQNVLLSAGCDNVILVWDV 161 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 37/164 (22%), Positives = 66/164 (40%), Gaps = 11/164 (6%) Query: 237 DVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHED 296 DVR + TT D+ C +A +S G + L + + + + GH Sbjct: 27 DVRVSQTTWDSGFCAVNPKFMALICEASG----GGAFLVLPLGKTGRVDKNVPLVCGHTA 82 Query: 297 AVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVN 356 V ++ + H D V+ S D +M+W++ G P + E ++ GH V Sbjct: 83 PVLDIAWCPHNDNVIASGSEDCTVMVWEIPD-GGLVLP------LREPVITLEGHTKRVG 135 Query: 357 DFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDII 400 +P ++ SA +N++ VW ++ P V+ D I Sbjct: 136 IVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTI 179 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 39/185 (21%), Positives = 78/185 (42%), Gaps = 18/185 (9%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-----LQS---TLKFHKDNGYALSF 168 H + + P + N++A+ + TV ++ +G L+ TL+ H +++ Sbjct: 80 HTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAW 139 Query: 169 STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWN-DLHSDIINDNKWHNFNKDLFGTV 227 + LLS D+ + +W+VG+G V T D+H D I W + L T Sbjct: 140 HPTAQNVLLSAGCDNVILVWDVGTGAA----VLTLGPDVHPDTIYSVDWSR-DGALICTS 194 Query: 228 SEDSLLKINDVRANNTTIDTVK---CPQPFNTLAFSHHSSNLLAAAGM-DSYVYLYDLRN 283 D +++ + R + + +P + + S + M + V L+D ++ Sbjct: 195 CRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKH 254 Query: 284 MKEPL 288 ++EPL Sbjct: 255 LEEPL 259 >5WLC-LU nrPDB Length = 489 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/152 (25%), Positives = 69/152 (45%), Gaps = 38/152 (25%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNK-DLFGTVSEDSLLK 234 +LS SDD TV LW IN + + N N D +E+ L++ Sbjct: 136 MLSCSDDKTVKLWS---------------------INVDDYSNKNSSDNDSVTNEEGLIR 174 Query: 235 INDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH 294 D + ID SH ++ A G + ++L+D+ +K P+ +S Sbjct: 175 TFDGESAFQGID-------------SHRENSTFATGG--AKIHLWDVNRLK-PVSDLSWG 218 Query: 295 EDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 D + +L+F+ + ++ S+GSDN ++++DL+ Sbjct: 219 ADNITSLKFNQNETDILASTGSDNSIVLYDLR 250 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/132 (25%), Positives = 61/132 (46%), Gaps = 10/132 (7%) Query: 185 VALWEVGSGGDPTKPVR--TWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANN 242 + LW+V + KPV +W +D I K++ D+ + D+ + + D+R N+ Sbjct: 201 IHLWDV----NRLKPVSDLSWG---ADNITSLKFNQNETDILASTGSDNSIVLYDLRTNS 253 Query: 243 TTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLE 302 T V+ + N + ++ + A D Y YD+RN+ L+ H AV +++ Sbjct: 254 PTQKIVQTMRT-NAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVD 312 Query: 303 FSTHVDGVVVSS 314 FS D +V S Sbjct: 313 FSPTGDEIVTGS 324 >6N9G-C nrPDB Length = 353 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 94/215 (43%), Gaps = 22/215 (10%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG--LQSTLKFHKDNGYALSFS---TL 171 H ++ + D I+ T +G GT L+ G LQS FH L + Sbjct: 152 HTNYLSACSFTNSDMQIL-TASGDGTCALWDVESGQLLQS---FHGHGADVLCLDLAPSE 207 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 +SG D +W++ SG + V+ + SD+ N +++ + D F + S+D+ Sbjct: 208 TGNTFVSGGCDKKAMVWDMRSG----QCVQAFETHESDV-NSVRYYP-SGDAFASGSDDA 261 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSY-VYLYD-LRNMKEPLH 289 ++ D+RA+ K F + S L AG + Y + ++D L+ + + Sbjct: 262 TCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSI- 320 Query: 290 HMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMW 323 + GHE+ V+ L S DG SGS D+ L +W Sbjct: 321 -LFGHENRVSTLRVSP--DGTAFCSGSWDHTLRVW 352 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 36/74 (48%), Gaps = 3/74 (4%) Query: 254 FNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFS-THVDGVVV 312 + +F++ +L A+G D L+D+ + + L GH V L+ + + V Sbjct: 156 LSACSFTNSDMQILTASG-DGTCALWDVES-GQLLQSFHGHGADVLCLDLAPSETGNTFV 213 Query: 313 SSGSDNRLMMWDLK 326 S G D + M+WD++ Sbjct: 214 SGGCDKKAMVWDMR 227 >5OQL-J nrPDB Length = 912 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 42/149 (28%), Positives = 65/149 (43%), Gaps = 27/149 (18%) Query: 152 LQSTLKFHKDNGYALSFSTL-----------VKGR--LLSGSDDHTVALWEVGSGGDPTK 198 +Q L+ HK + + F+ L V GR +L+GS D T+ LW + D T Sbjct: 578 VQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNL---SDYT- 633 Query: 199 PVRTWNDLHSDIINDNKWHNFNKD--------LFGTVSEDSLLKINDVRANNTTIDTVKC 250 +RT+ HS + W + ++D F + D+L+K+ D T Sbjct: 634 CIRTFEG-HSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNH 692 Query: 251 PQPFNTLAFSHHSSNLLAAAGMDSYVYLY 279 TLA H +N+LA+AG DS V + Sbjct: 693 EDRLWTLAV-HSKTNILASAGSDSKVTFW 720 Score = 32.0 bits (71), Expect = 0.54, Method: Compositional matrix adjust. Identities = 27/129 (20%), Positives = 52/129 (40%), Gaps = 20/129 (15%) Query: 265 NLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEF-------------STHVDGVV 311 L A+A D V ++D+ + E + GH+ V + F S GVV Sbjct: 557 KLFASASQDKTVKIWDVEKL-EVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVV 615 Query: 312 VSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASA 371 ++ D + +W+L +T + V +++ +H S+ + ASA Sbjct: 616 LTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQ------FASA 669 Query: 372 EEENILQVW 380 + +++VW Sbjct: 670 GADTLVKVW 678 >4V8M-A7 nrPDB Length = 318 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/177 (22%), Positives = 83/177 (46%), Gaps = 22/177 (12%) Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL 266 HS ++D N N + + S D L++ +++ + + ++AFS + + Sbjct: 66 HSAFVSDVALSN-NGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQI 124 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMS--GHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMW 323 ++ G D+ + +++++ E +H +S H D V+ + FS +D V+VS G DN + +W Sbjct: 125 VSG-GRDNALRVWNVKG--ECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVW 181 Query: 324 DLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 DL L+ GH + V ++P L AS++++ + ++W Sbjct: 182 DL--------------ATGRLVTDLKGHTNYVTSVTVSPDGS-LCASSDKDGVARLW 223 >5M25-A nrPDB Length = 434 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 90/399 (22%), Positives = 155/399 (38%), Gaps = 95/399 (23%) Query: 45 TPVQELDGGFIKQELIIGTHTSGEEENYLKF------AEINLPKEILSNEDP------QE 92 TP++ L F K++ G+E + L+F + + E L ED +E Sbjct: 66 TPLRRLMEAFAKRQ--------GKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHRE 117 Query: 93 EAGEEYQSSLPAP-RSNIRITAKYE-HEEEITRARYMPQDPNIVATINGQGTVFLYSRSE 150 + G S P P + N + H + ++ ++ P + +A+ + + ++ + Sbjct: 118 QIGGSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYD 176 Query: 151 GLQSTLKFHKD-NGYALSFSTLV----KGRLLSGSDDHTVALWEVGSG------------ 193 G KF K +G+ L S + L+S SDD T+ +W+V SG Sbjct: 177 G-----KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 231 Query: 194 ---------------GDPTKPVRTWNDLHSDIINDNKWHN-------FNKD--LFGTVSE 229 G + VR W+ + H+ FN+D L + S Sbjct: 232 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 291 Query: 230 DSLLKINDVRAN---NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE 286 D L +I D + T ID P F + FS + +LAA +D+ + L+D K Sbjct: 292 DGLCRIWDTASGQCLKTLIDDDNPPVSF--VKFSPNGKYILAAT-LDNTLKLWDYSKGK- 347 Query: 287 PLHHMSGHEDAVNNL--EFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 L +GH++ + FS +VS DN + +W+L+ E+ Sbjct: 348 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ--------------TKEI 393 Query: 345 IMVHAGHRSSVNDFDLNPQIPWLVASAEEEN--ILQVWK 381 + GH V +P ++ASA EN +++WK Sbjct: 394 VQKLQGHTDVVISTACHPTEN-IIASAALENDKTIKLWK 431 >1VYH-C nrPDB Length = 410 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 38/155 (24%), Positives = 65/155 (41%), Gaps = 18/155 (11%) Query: 226 TVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMK 285 + SED+ +K+ D + ++F H S LLA+ D + L+D + Sbjct: 125 SASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH-SGKLLASCSADMTIKLWDFQGF- 182 Query: 286 EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELI 345 E + M GH+ V+++ + D +VS+ D + MW++ Q G + Sbjct: 183 ECIRTMHGHDHNVSSVSIMPNGDH-IVSASRDKTIKMWEV-QTGY-------------CV 227 Query: 346 MVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 GHR V N Q L+AS + ++VW Sbjct: 228 KTFTGHREWVRMVRPN-QDGTLIASCSNDQTVRVW 261 Score = 32.7 bits (73), Expect = 0.30, Method: Compositional matrix adjust. Identities = 25/107 (23%), Positives = 50/107 (46%), Gaps = 7/107 (6%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 LLSGS D T+ +W+V +G V H + + +H+ K + + ++D L++ Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVG-----HDNWVRGVLFHSGGKFIL-SCADDKTLRV 364 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLR 282 D + N + T+ + F T H ++ + +D V +++ R Sbjct: 365 WDYK-NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 28.5 bits (62), Expect = 6.0, Method: Compositional matrix adjust. Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 1/60 (1%) Query: 291 MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 +SGH V + F V V+VS+ D + +WD + E+T D V ++ H+G Sbjct: 104 LSGHRSPVTRVIFHP-VFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162 >1PI6-A nrPDB Length = 615 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 17/61 (27%), Positives = 37/61 (60%), Gaps = 2/61 (3%) Query: 265 NLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD 324 +L+A +D+ +++Y ++ + + ++ H+D VNNL + T +VSSG+D + W+ Sbjct: 554 DLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWET--PSTLVSSGADACIKRWN 611 Query: 325 L 325 + Sbjct: 612 V 612 >5Z56-q nrPDB Length = 504 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 43/170 (25%), Positives = 78/170 (45%), Gaps = 8/170 (4%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTLKFHKDNGYALSFSTLVKGR 175 H +++T + P ++V + + T+ ++S + ++ H+ LS Sbjct: 263 HTKKVTSVVFHPSQ-DLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHA-TGDY 320 Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 LLS SDD A ++ +G TK ++ + ++H + +FGT + DS +KI Sbjct: 321 LLSSSDDQYWAFSDIQTGRVLTK---VTDETSGCSLTCAQFHP-DGLIFGTGTMDSQIKI 376 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMK 285 D++ + P ++AFS + LA A DS V L+DLR +K Sbjct: 377 WDLKERTNVANFPGHSGPITSIAFSEN-GYYLATAADDSSVKLWDLRKLK 425 >5A31-R nrPDB Length = 386 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 37/165 (22%), Positives = 66/165 (40%), Gaps = 21/165 (12%) Query: 248 VKCPQPFNTLAFSHH----------SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDA 297 V+ P PF SH + N LA+ G D+ V++Y+ K P+ H+ A Sbjct: 200 VRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE-GTSKSPILTFDEHKAA 258 Query: 298 VNNLEFSTHVDGVVVSSG--SDNRLMMWDLKQ--------IGAEQTPDDAEDGVPELIMV 347 V + +S H GV+ + G +D RL +W++ G++ EL+ Sbjct: 259 VKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTS 318 Query: 348 HAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGP 392 H + ++ +D N P + +L + + +V G Sbjct: 319 HGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGA 363 >6ID0-T nrPDB Length = 514 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 45/206 (21%), Positives = 83/206 (40%), Gaps = 25/206 (12%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 ++GS D T+ +W++ SG + + I++ + F + ED +K Sbjct: 219 FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLF------SCGEDKQVKC 272 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHE 295 D+ N L H + ++L DS ++D+R K +H +SGH Sbjct: 273 WDLEYNKVIRHYHGHLSAVYGLDL-HPTIDVLVTCSRDSTARIWDVRT-KASVHTLSGHT 330 Query: 296 DAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSV 355 +AV + + +++ D + +WDL G + + + H+ SV Sbjct: 331 NAVATVRCQA-AEPQIITGSHDTTIRLWDLVA------------GKTRVTLTN--HKKSV 375 Query: 356 NDFDLNPQIPWLVASAEEENILQVWK 381 L+P+ + AS +NI Q WK Sbjct: 376 RAVVLHPR-HYTFASGSPDNIKQ-WK 399 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 37/178 (20%), Positives = 76/178 (42%), Gaps = 27/178 (15%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 L++ S D T +W+V + V T + H++ + + + T S D+ +++ Sbjct: 303 LVTCSRDSTARIWDVRTKAS----VHTLSG-HTNAVATVRCQAAEPQII-TGSHDTTIRL 356 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEP----LHHM 291 D+ A T + + + H + A+G +++ K P + ++ Sbjct: 357 WDLVAGKTRVTLTNHKKSVRAVVL--HPRHYTFASGSPD-----NIKQWKFPDGSFIQNL 409 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD------LKQIGAEQTPD--DAEDGV 341 SGH +N L ++ DGV+VS + + +WD +++ A P D+E G+ Sbjct: 410 SGHNAIINTLTVNS--DGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGI 465 >4BH6-A nrPDB Length = 308 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 37/165 (22%), Positives = 66/165 (40%), Gaps = 21/165 (12%) Query: 248 VKCPQPFNTLAFSHH----------SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDA 297 V+ P PF SH + N LA+ G D+ V++Y+ K P+ H+ A Sbjct: 131 VRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE-GTSKSPILTFDEHKAA 189 Query: 298 VNNLEFSTHVDGVVVSSG--SDNRLMMWDLKQ--------IGAEQTPDDAEDGVPELIMV 347 V + +S H GV+ + G +D RL +W++ G++ EL+ Sbjct: 190 VKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTS 249 Query: 348 HAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGP 392 H + ++ +D N P + +L + + +V G Sbjct: 250 HGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGA 294 >6HHQ-h nrPDB Length = 319 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 59/242 (24%), Positives = 105/242 (43%), Gaps = 34/242 (14%) Query: 152 LQSTLKFHKDNGYALSFSTLVK--GRLLSGSDDHTVALWEVGSGGDPTK---PVRTWNDL 206 L+ TL+ H NG+ S +T LLS S D T+ W++ GD K PVR++ Sbjct: 9 LRGTLEGH--NGWVTSLATSAGQPNLLLSASRDKTLISWKL--TGDDQKFGVPVRSFKG- 63 Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL 266 HS I+ D + + S D L++ DV T V ++ +S + Sbjct: 64 HSHIVQDCT-LTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMI 122 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEF----STHVDGV-VVSSGSDNRLM 321 ++ + D + ++ ++ + L + GH D V+ + D V ++S+G+D + Sbjct: 123 ISGS-RDKTIKVWTIKG--QCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVK 179 Query: 322 MWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 W+L Q E + I GH S++N +P L+ASA ++ + +W Sbjct: 180 AWNLNQFQIE----------ADFI----GHNSNINTLTASPDGT-LIASAGKDGEIMLWN 224 Query: 382 CS 383 + Sbjct: 225 LA 226 Score = 31.6 bits (70), Expect = 0.58, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 11/104 (10%) Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDL 325 + +AG D V ++L + + GH +N L S DG ++ S+G D +M+W+L Sbjct: 169 IISAGNDKMVKAWNLNQFQIEADFI-GHNSNINTLTASP--DGTLIASAGKDGEIMLWNL 225 Query: 326 KQIGAEQTPDDAEDGV------PELIMVHAGHRSSVNDFDLNPQ 363 A T A+D V P + A + + F L+PQ Sbjct: 226 AAKKAMYTL-SAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQ 268 >5K1B-B nrPDB Length = 677 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 41/203 (20%), Positives = 88/203 (43%), Gaps = 16/203 (7%) Query: 157 KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW 216 K++++ AL + RL + D + +W V P + H+D +ND Sbjct: 27 KYNRNGVNALQLDPAL-NRLFTAGRDSIIRIWSVNQ--HKQDPYIASMEHHTDWVNDIVL 83 Query: 217 HNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPF-NTLAFSHHSSNLLAAAGMDSY 275 K L + S D+ +K+ + + T++ + + LA++ L+A+AG+D Sbjct: 84 CCNGKTLI-SASSDTTVKVWNAH-KGFCMSTLRTHKDYVKALAYAK-DKELVASAGLDRQ 140 Query: 276 VYLYDLRNMKE--------PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 ++L+D+ + +SG++D++ +L + + ++VS ++ L +WD + Sbjct: 141 IFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMN-QLGTIIVSGSTEKVLRVWDPRT 199 Query: 328 IGAEQTPDDAEDGVPELIMVHAG 350 D V L++ G Sbjct: 200 CAKLMKLKGHTDNVKALLLNRDG 222 >4BTS-AR nrPDB Length = 343 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 49/222 (22%), Positives = 87/222 (39%), Gaps = 40/222 (18%) Query: 176 LLSGSDDHTVALWEV------GSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 L+SGS D TV +W++ G G P K + N SD+ ++ F S Sbjct: 42 LISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALS------QENCFAISSS 95 Query: 230 -DSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD-LRNMKEP 287 D L++ D+R T V ++AFS + +L +AG + + L++ L K Sbjct: 96 WDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQIL-SAGAEREIKLWNILGECKFS 154 Query: 288 LHHMSGHEDAVNNLEFSTHVDGV---------VVSSGSDNRLMMWDLKQIGAEQTPDDAE 338 H D V+ + +S + S G D RL +W+ Sbjct: 155 SAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTN------------ 202 Query: 339 DGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 ++ H S+VN ++P ++ +++ +L +W Sbjct: 203 ---FQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLL-IW 240 >4LG8-A nrPDB Length = 354 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 5/110 (4%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 LLS SDD A ++ +G TK ++ + ++H + +FGT + DS +KI Sbjct: 171 LLSSSDDQYWAFSDIQTGRVLTKVT---DETSGCSLTCAQFHP-DGLIFGTGTMDSQIKI 226 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMK 285 D++ + P ++AFS + LA A DS V L+DLR +K Sbjct: 227 WDLKERTNVANFPGHSGPITSIAFSEN-GYYLATAADDSSVKLWDLRKLK 275 >4G56-B nrPDB Length = 357 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 45/196 (22%), Positives = 81/196 (41%), Gaps = 13/196 (6%) Query: 113 AKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLV 172 AKYEH++ I + + D + +V ++ S+ ++ LK + + ++ Sbjct: 134 AKYEHDD-IVKTLSVFSDGTQAVSGGKDFSVKVWDLSQ--KAVLKSYNAHSSEVNCVAAC 190 Query: 173 KGR---LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII-NDNKWHNFNKDLFGTVS 228 G+ LS +D + LW+ KP + SD I WH D F Sbjct: 191 PGKDTIFLSCGEDGRILLWDT----RKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGD 246 Query: 229 EDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPL 288 E + + +++ ++ + Q LA+S+HSS LA+ D V + D + E Sbjct: 247 ETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDA-DFSEVF 305 Query: 289 HHMSGHEDAVNNLEFS 304 +S H D V + +S Sbjct: 306 RDLS-HRDFVTGVAWS 320 >5TF2-A nrPDB Length = 407 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 23/96 (23%), Positives = 46/96 (47%), Gaps = 7/96 (7%) Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 L++ +++A T + P + +H + LLA G D YV ++ + ++++ L Sbjct: 157 LRVENLQAVQTDFSS----DPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVL-EFK 211 Query: 293 GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 HE + +L DG +V+ G D + +W Q+ Sbjct: 212 AHEGEIEDLALGP--DGKLVTVGRDLKASVWQKDQL 245 >2H9P-A nrPDB Length = 329 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 73/316 (23%), Positives = 126/316 (39%), Gaps = 79/316 (25%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKD-NGYALSFSTLV--- 172 H + ++ ++ P + +A+ + + ++ +G KF K +G+ L S + Sbjct: 39 HTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDG-----KFEKTISGHKLGISDVAWSS 92 Query: 173 -KGRLLSGSDDHTVALWEVGSG---------------------------GDPTKPVRTWN 204 L+S SDD T+ +W+V SG G + VR W+ Sbjct: 93 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 152 Query: 205 ----------DLHSDIINDNKWHNFNKD--LFGTVSEDSLLKINDVRAN---NTTIDTVK 249 HSD ++ +FN+D L + S D L +I D + T ID Sbjct: 153 VKTGKCLKTLPAHSDPVSA---VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 209 Query: 250 CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNL--EFSTHV 307 P F + FS + +LAA +D+ + L+D K L +GH++ + FS Sbjct: 210 PPVSF--VKFSPNGKYILAAT-LDNTLKLWDYSKGK-CLKTYTGHKNEKYCIFANFSVTG 265 Query: 308 DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWL 367 +VS DN + +W+L+ E++ GH V +P + Sbjct: 266 GKWIVSGSEDNLVYIWNLQ--------------TKEIVQKLQGHTDVVISTACHPTEN-I 310 Query: 368 VASAEEEN--ILQVWK 381 +ASA EN +++WK Sbjct: 311 IASAALENDKTIKLWK 326 >3W15-A nrPDB Length = 368 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 30/128 (23%), Positives = 55/128 (42%), Gaps = 11/128 (8%) Query: 259 FSHHSSNLLAAAGMDSYVYLYDLR-----NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVS 313 FS H NL+ + +SY L+D+R N L H SG E +F+ + VV + Sbjct: 184 FSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH-SGLEALT--CDFNKYRPYVVAT 240 Query: 314 SGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEE 373 G DN + +WD++ + + E+ H ++ +P ++ SA Sbjct: 241 GGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHG---LAIRKVTWSPHHSNILMSASY 297 Query: 374 ENILQVWK 381 + ++W+ Sbjct: 298 DMTCRIWR 305 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 37/139 (26%), Positives = 64/139 (46%), Gaps = 15/139 (10%) Query: 256 TLAFSHHSSNLLAAAGMDSYVYLYDLRNM-KEP--LHHMS-------GHEDAVNNLEFST 305 T F+ + ++A G+D+ + ++D+R + K P LH+ S H A+ + +S Sbjct: 227 TCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSP 286 Query: 306 HVDGVVVSSGSDNRLMMW-DLKQIGAEQT-PDDAEDGVPELIMVHAGHRSSV--NDFDLN 361 H +++S+ D +W DL GA++T ++ D I H V D+ L Sbjct: 287 HHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLW 346 Query: 362 PQIPWLVASAEEENILQVW 380 + P VAS + L VW Sbjct: 347 GK-PGYVASTAWDGNLFVW 364 >5WYJ-BC nrPDB Length = 817 Score = 35.8 bits (81), Expect = 0.031, Method: Compositional matrix adjust. Identities = 37/154 (24%), Positives = 68/154 (44%), Gaps = 25/154 (16%) Query: 227 VSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE 286 VS+ LLKI ++ + ++K P L + +S LLA G D + + D+ N Sbjct: 79 VSQAQLLKIFHLKTGKV-VRSMKISSPSYILD-ADSTSTLLAVGGTDGSIIVVDIEN-GY 135 Query: 287 PLHHMSGHEDAVNNLEFSTHVDGVV--VSSGSDNRLM-MWDL----------------KQ 327 H GH +++L+F ++ + ++SG N ++ +WDL + Sbjct: 136 ITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRG 195 Query: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLN 361 + + PD+ E P L ++ G +N +D N Sbjct: 196 LDIIEVPDNDE---PSLNLLSGGRDDIINLWDFN 226 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 26/45 (57%), Gaps = 7/45 (15%) Query: 348 HAGHRSSVNDF-DLNPQIPWLVASAEEENILQVW-----KCSHSL 386 H G SS+ + LN +I WL+AS + +++VW KC H+L Sbjct: 143 HGGTISSLKFYGQLNSKI-WLLASGDTNGMVKVWDLVKRKCLHTL 186 >5G04-R nrPDB Length = 499 Score = 35.4 bits (80), Expect = 0.041, Method: Compositional matrix adjust. Identities = 63/279 (22%), Positives = 111/279 (39%), Gaps = 49/279 (17%) Query: 142 TVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLS-GSDDHTVALWEVGSGGDPTKP 199 +V+L+S S G + L+ + Y S + + +G L+ G+ V LW+V K Sbjct: 205 SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV----QQQKR 260 Query: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKC-PQPFNTLA 258 +R HS + W+++ + + S + +DVR + T+ Q L Sbjct: 261 LRNMTS-HSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLR 316 Query: 259 FSHHSSNLLAAAGMDSYVYLYDLRNMKE---PLHHMSGHEDAVNNLEFSTHVDGVVVSSG 315 ++ +L A+ G D+ V ++ + PL + H+ AV + + V+ + G Sbjct: 317 WAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 375 Query: 316 --SDNRLMMWDLKQIGAEQTPDDAEDGV---------PELIMVHA--------------- 349 SD + +W++ GA + DA V ELI H Sbjct: 376 GTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 434 Query: 350 ------GHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 GH S V ++P VASA + L++W+C Sbjct: 435 KVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRC 472 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 37/164 (22%), Positives = 76/164 (46%), Gaps = 12/164 (7%) Query: 162 NGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-HNFN 220 N Y L+ G +L+ + D++V LW S GD + ++ + + I+ W N Sbjct: 183 NDYYLNLVDWSSGNVLAVALDNSVYLWSA-SSGDILQLLQM--EQPGEYISSVAWIKEGN 239 Query: 221 KDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD 280 GT S + +++ DV+ + +L++ +S +L++ +++ +D Sbjct: 240 YLAVGTSSAE--VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHD 294 Query: 281 LRNMKEPLHHMSGHEDAVNNLEFSTHVDGV-VVSSGSDNRLMMW 323 +R + + +SGH V L ++ DG + S G+DN + +W Sbjct: 295 VRVAEHHVATLSGHSQEVCGLRWAP--DGRHLASGGNDNLVNVW 336 >1NR0-A nrPDB Length = 611 Score = 35.4 bits (80), Expect = 0.042, Method: Compositional matrix adjust. Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 10/85 (11%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKG- 174 EH + + RY P D ++ A+ G GT+ LY+ +G ++ + F D+ ++ S V G Sbjct: 188 EHTKFVHSVRYNP-DGSLFASTGGDGTIVLYNGVDGTKTGV-FEDDSLKNVAHSGSVFGL 245 Query: 175 -------RLLSGSDDHTVALWEVGS 192 ++ S S D T+ +W V + Sbjct: 246 TWSPDGTKIASASADKTIKIWNVAT 270 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 40/72 (55%), Gaps = 7/72 (9%) Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED-SLL 233 R++SGSDD+TVA++E G P K T+ + H+ ++ ++ N + LF + D +++ Sbjct: 162 RIISGSDDNTVAIFE----GPPFKFKSTFGE-HTKFVHSVRY-NPDGSLFASTGGDGTIV 215 Query: 234 KINDVRANNTTI 245 N V T + Sbjct: 216 LYNGVDGTKTGV 227 >5GAN-H nrPDB Length = 465 Score = 35.4 bits (80), Expect = 0.042, Method: Compositional matrix adjust. Identities = 32/130 (24%), Positives = 62/130 (47%), Gaps = 6/130 (4%) Query: 200 VRTWNDL--HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTL 257 +R DL H I+D K+H K G+ S D ++ D + + + +L Sbjct: 255 LRLLGDLVGHERRISDVKYHPSGK-FIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSL 313 Query: 258 AFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSD 317 +F S L+ + GMDS L+D+R+ + + ++GH + + +S + V + G D Sbjct: 314 SFQCDGS-LVCSGGMDSLSMLWDIRSGSKVM-TLAGHSKPIYTVAWSPN-GYQVATGGGD 370 Query: 318 NRLMMWDLKQ 327 + +WD+++ Sbjct: 371 GIINVWDIRK 380 >3JZG-A nrPDB Length = 402 Score = 35.4 bits (80), Expect = 0.042, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 20/133 (15%) Query: 254 FNTLAFSHHSSN---LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGV 310 F T A+++ S+ LLA AG + + + M + + H GH +A+N L+F + Sbjct: 108 FYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM-QCIKHYVGHGNAINELKFHPRDPNL 166 Query: 311 VVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSV--NDFDLNPQIPWLV 368 ++S D+ L +W+++ D + + GHR V D+DL + + Sbjct: 167 LLSVSKDHALRLWNIQT-----------DTLVAIFGGVEGHRDEVLSADYDLLGE---KI 212 Query: 369 ASAEEENILQVWK 381 S ++ L++W+ Sbjct: 213 MSCGMDHSLKLWR 225 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 17/80 (21%), Positives = 44/80 (55%), Gaps = 5/80 (6%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQST---LKFHKDNGYALSFSTLV 172 H I ++ P+DPN++ +++ + L++ +++ L + ++ H+D + + L+ Sbjct: 150 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD-LL 208 Query: 173 KGRLLSGSDDHTVALWEVGS 192 +++S DH++ LW + S Sbjct: 209 GEKIMSCGMDHSLKLWRINS 228 >5LCW-Q nrPDB Length = 374 Score = 35.4 bits (80), Expect = 0.044, Method: Compositional matrix adjust. Identities = 63/279 (22%), Positives = 111/279 (39%), Gaps = 49/279 (17%) Query: 142 TVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLS-GSDDHTVALWEVGSGGDPTKP 199 +V+L+S S G + L+ + Y S + + +G L+ G+ V LW+V K Sbjct: 80 SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV----QQQKR 135 Query: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKC-PQPFNTLA 258 +R HS + W+++ + + S + +DVR + T+ Q L Sbjct: 136 LRNMTS-HSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLR 191 Query: 259 FSHHSSNLLAAAGMDSYVYLYDLRNMKE---PLHHMSGHEDAVNNLEFSTHVDGVVVSSG 315 ++ +L A+ G D+ V ++ + PL + H+ AV + + V+ + G Sbjct: 192 WAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 250 Query: 316 --SDNRLMMWDLKQIGAEQTPDDAEDGV---------PELIMVHA--------------- 349 SD + +W++ GA + DA V ELI H Sbjct: 251 GTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 309 Query: 350 ------GHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 GH S V ++P VASA + L++W+C Sbjct: 310 KVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRC 347 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 37/164 (22%), Positives = 76/164 (46%), Gaps = 12/164 (7%) Query: 162 NGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-HNFN 220 N Y L+ G +L+ + D++V LW S GD + ++ + + I+ W N Sbjct: 58 NDYYLNLVDWSSGNVLAVALDNSVYLWSA-SSGDILQLLQM--EQPGEYISSVAWIKEGN 114 Query: 221 KDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD 280 GT S + +++ DV+ + +L++ +S +L++ +++ +D Sbjct: 115 YLAVGTSSAE--VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHD 169 Query: 281 LRNMKEPLHHMSGHEDAVNNLEFSTHVDGV-VVSSGSDNRLMMW 323 +R + + +SGH V L ++ DG + S G+DN + +W Sbjct: 170 VRVAEHHVATLSGHSQEVCGLRWAP--DGRHLASGGNDNLVNVW 211 >4GGA-A nrPDB Length = 420 Score = 35.4 bits (80), Expect = 0.048, Method: Compositional matrix adjust. Identities = 63/279 (22%), Positives = 111/279 (39%), Gaps = 49/279 (17%) Query: 142 TVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLS-GSDDHTVALWEVGSGGDPTKP 199 +V+L+S S G + L+ + Y S + + +G L+ G+ V LW+V K Sbjct: 126 SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV----QQQKR 181 Query: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKC-PQPFNTLA 258 +R HS + W+++ + + S + +DVR + T+ Q L Sbjct: 182 LRNMTS-HSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLR 237 Query: 259 FSHHSSNLLAAAGMDSYVYLYDLRNMKE---PLHHMSGHEDAVNNLEFSTHVDGVVVSSG 315 ++ +L A+ G D+ V ++ + PL + H+ AV + + V+ + G Sbjct: 238 WAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 296 Query: 316 --SDNRLMMWDLKQIGAEQTPDDAEDGV---------PELIMVHA--------------- 349 SD + +W++ GA + DA V ELI H Sbjct: 297 GTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 355 Query: 350 ------GHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 GH S V ++P VASA + L++W+C Sbjct: 356 KVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRC 393 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 37/164 (22%), Positives = 76/164 (46%), Gaps = 12/164 (7%) Query: 162 NGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-HNFN 220 N Y L+ G +L+ + D++V LW S GD + ++ + + I+ W N Sbjct: 104 NDYYLNLVDWSSGNVLAVALDNSVYLWSA-SSGDILQLLQM--EQPGEYISSVAWIKEGN 160 Query: 221 KDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD 280 GT S + +++ DV+ + +L++ +S +L++ +++ +D Sbjct: 161 YLAVGTSSAE--VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHD 215 Query: 281 LRNMKEPLHHMSGHEDAVNNLEFSTHVDGV-VVSSGSDNRLMMW 323 +R + + +SGH V L ++ DG + S G+DN + +W Sbjct: 216 VRVAEHHVATLSGHSQEVCGLRWAP--DGRHLASGGNDNLVNVW 257 >5XYI-g nrPDB Length = 335 Score = 35.4 bits (80), Expect = 0.050, Method: Compositional matrix adjust. Identities = 42/199 (21%), Positives = 87/199 (43%), Gaps = 22/199 (11%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 LL+ S D T+ LW++ T+ + H + + N+ + +V D+ +KI Sbjct: 95 LLTSSWDSTLRLWDLS-----TRTTKKLFLGHKKDVLGVTFSPCNRRII-SVGRDNQVKI 148 Query: 236 NDVRANNTTIDTVKCPQPFNTLA---FSHHSSNLLAAAGM-DSYVYLYDLRNMKEPLHHM 291 ++ N ++C ++A + +S L+ A G D VY++ + + + Sbjct: 149 WNILGENKA--ELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEF 206 Query: 292 SGHEDAVNNLEFSTHVDGV-VVSSGSDNRLMMWDLKQIGAEQ------TPDDAEDGVPEL 344 H+ +++F+ DG V++ GSD +++MW L + GA+ +P A P Sbjct: 207 KAHDGRCTSVDFTP--DGKWVITGGSDRKVVMW-LTENGAKTISFTAPSPVHAVAACPTQ 263 Query: 345 IMVHAGHRSSVNDFDLNPQ 363 + A + +D+ + Sbjct: 264 AWICAATYEGIAVWDIGAK 282 >6QDV-o nrPDB Length = 513 Score = 35.0 bits (79), Expect = 0.054, Method: Compositional matrix adjust. Identities = 18/62 (29%), Positives = 31/62 (50%), Gaps = 1/62 (1%) Query: 263 SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 S +LL + MD + L+++ + L GH AV ++ F+T +S+ D L + Sbjct: 234 SGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNT-AGTQFLSAAYDRYLKL 292 Query: 323 WD 324 WD Sbjct: 293 WD 294 >5WLC-LO nrPDB Length = 923 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 38/183 (20%), Positives = 85/183 (46%), Gaps = 9/183 (4%) Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 R+++ S+D + +W++ SG + T+ + H+ + ++ + +F + + ++ Sbjct: 359 RVVTASEDGKIKVWDITSGF----CLATFEE-HTSSVTAVQFAKRGQVMFSSSLDGTVRA 413 Query: 235 INDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSY-VYLYDLRNMKEPLHHMSG 293 + +R N T FN LA S ++ A +D++ ++++ ++ + L +SG Sbjct: 414 WDLIRYRNFRTFTGTERIQFNCLAVD-PSGEVVCAGSLDNFDIHVWSVQT-GQLLDALSG 471 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 HE V+ L FS + V+ S+ D + +W + + P + V L M G Sbjct: 472 HEGPVSCLSFSQE-NSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEV 530 Query: 354 SVN 356 +V+ Sbjct: 531 AVS 533 >5YZG-W nrPDB Length = 579 Score = 35.0 bits (79), Expect = 0.059, Method: Compositional matrix adjust. Identities = 18/62 (29%), Positives = 31/62 (50%), Gaps = 1/62 (1%) Query: 263 SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 S +LL + MD + L+++ + L GH AV ++ F+T +S+ D L + Sbjct: 300 SGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNT-AGTQFLSAAYDRYLKL 358 Query: 323 WD 324 WD Sbjct: 359 WD 360 >5I2T-A nrPDB Length = 742 Score = 34.7 bits (78), Expect = 0.077, Method: Compositional matrix adjust. Identities = 38/183 (20%), Positives = 85/183 (46%), Gaps = 9/183 (4%) Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 R+++ S+D + +W++ SG + T+ + H+ + ++ + +F + + ++ Sbjct: 384 RVVTASEDGKIKVWDITSGF----CLATFEE-HTSSVTAVQFAKRGQVMFSSSLDGTVRA 438 Query: 235 INDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSY-VYLYDLRNMKEPLHHMSG 293 + +R N T FN LA S ++ A +D++ ++++ ++ + L +SG Sbjct: 439 WDLIRYRNFRTFTGTERIQFNCLAVD-PSGEVVCAGSLDNFDIHVWSVQT-GQLLDALSG 496 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 HE V+ L FS + V+ S+ D + +W + + P + V L M G Sbjct: 497 HEGPVSCLSFSQE-NSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEV 555 Query: 354 SVN 356 +V+ Sbjct: 556 AVS 558 >6MZM-G nrPDB Length = 800 Score = 34.7 bits (78), Expect = 0.081, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 39/66 (59%), Gaps = 4/66 (6%) Query: 261 HHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNR 319 H +SN +A D V L+D+ N + +GH+ +++L FS +G +++G+ D R Sbjct: 636 HPNSNYVATGSADRTVRLWDVLN-GNCVRIFTGHKGPIHSLTFSP--NGRFLATGATDGR 692 Query: 320 LMMWDL 325 +++WD+ Sbjct: 693 VLLWDI 698 Score = 31.6 bits (70), Expect = 0.60, Method: Compositional matrix adjust. Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 7/87 (8%) Query: 109 IRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALS 167 +RI A H ++ R+ P + N VAT + TV L+ G HK ++L+ Sbjct: 620 LRIFAG--HLADVNCTRFHP-NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLT 676 Query: 168 FSTLVKGRLLS-GSDDHTVALWEVGSG 193 FS GR L+ G+ D V LW++G G Sbjct: 677 FSP--NGRFLATGATDGRVLLWDIGHG 701 Score = 30.8 bits (68), Expect = 0.96, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 13/88 (14%) Query: 132 NIVATINGQGTVFLYSRSEGLQ-STLKFHKDNGYALSFSTLVKGRLL-SGSDDHTVALWE 189 +AT G V L+ GL LK H D +L FS G +L SGS D+TV LW+ Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR--DGEILASGSMDNTVRLWD 739 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWH 217 ++ + DL +D H Sbjct: 740 A---------IKAFEDLETDDFTTATGH 758 >4N14-A nrPDB Length = 314 Score = 34.3 bits (77), Expect = 0.093, Method: Compositional matrix adjust. Identities = 63/279 (22%), Positives = 111/279 (39%), Gaps = 49/279 (17%) Query: 142 TVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLS-GSDDHTVALWEVGSGGDPTKP 199 +V+L+S S G + L+ + Y S + + +G L+ G+ V LW+V K Sbjct: 42 SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV----QQQKR 97 Query: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKC-PQPFNTLA 258 +R HS + W+++ + + S + +DVR + T+ Q L Sbjct: 98 LRNMTS-HSARVGSLSWNSY---ILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLR 153 Query: 259 FSHHSSNLLAAAGMDSYVYLYDLRNMKE---PLHHMSGHEDAVNNLEFSTHVDGVVVSSG 315 ++ +L A+ G D+ V ++ + PL + H+ AV + + V+ + G Sbjct: 154 WAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGG 212 Query: 316 --SDNRLMMWDLKQIGAEQTPDDAEDGV---------PELIMVHA--------------- 349 SD + +W++ GA + DA V ELI H Sbjct: 213 GTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMA 271 Query: 350 ------GHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 GH S V ++P VASA + L++W+C Sbjct: 272 KVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRC 309 Score = 29.3 bits (64), Expect = 3.4, Method: Compositional matrix adjust. Identities = 37/164 (22%), Positives = 76/164 (46%), Gaps = 12/164 (7%) Query: 162 NGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-HNFN 220 N Y L+ G +L+ + D++V LW S GD + ++ + + I+ W N Sbjct: 20 NDYYLNLVDWSSGNVLAVALDNSVYLWSA-SSGDILQLLQM--EQPGEYISSVAWIKEGN 76 Query: 221 KDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD 280 GT S + +++ DV+ + +L++ +S +L++ +++ +D Sbjct: 77 YLAVGTSSAE--VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHD 131 Query: 281 LRNMKEPLHHMSGHEDAVNNLEFSTHVDGV-VVSSGSDNRLMMW 323 +R + + +SGH V L ++ DG + S G+DN + +W Sbjct: 132 VRVAEHHVATLSGHSQEVCGLRWAP--DGRHLASGGNDNLVNVW 173 >6F3T-A nrPDB Length = 608 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 39/66 (59%), Gaps = 4/66 (6%) Query: 261 HHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSG-SDNR 319 H +SN +A D V L+D+ N + +GH+ +++L FS +G +++G +D R Sbjct: 444 HPNSNYVATGSADRTVRLWDVLN-GNCVRIFTGHKGPIHSLTFSP--NGRFLATGATDGR 500 Query: 320 LMMWDL 325 +++WD+ Sbjct: 501 VLLWDI 506 Score = 32.3 bits (72), Expect = 0.41, Method: Compositional matrix adjust. Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 7/87 (8%) Query: 109 IRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALS 167 +RI A H ++ R+ P + N VAT + TV L+ G HK ++L+ Sbjct: 428 LRIFAG--HLADVNCTRFHP-NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLT 484 Query: 168 FSTLVKGRLLS-GSDDHTVALWEVGSG 193 FS GR L+ G+ D V LW++G G Sbjct: 485 FSP--NGRFLATGATDGRVLLWDIGHG 509 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 27/80 (33%), Positives = 37/80 (46%), Gaps = 13/80 (16%) Query: 132 NIVATINGQGTVFLYSRSEGLQ-STLKFHKDNGYALSFSTLVKGRLL-SGSDDHTVALWE 189 +AT G V L+ GL LK H D +L FS G +L SGS D+TV LW+ Sbjct: 490 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR--DGEILASGSMDNTVRLWD 547 Query: 190 VGSGGDPTKPVRTWNDLHSD 209 ++ + DL +D Sbjct: 548 A---------IKAFEDLETD 558 >3ACP-A nrPDB Length = 417 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 52/231 (22%), Positives = 99/231 (42%), Gaps = 33/231 (14%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQ-STLKFHKDNGYALSFSTLVKGR 175 H EIT+ ++ P ++++ + ++S +G TL H+ + + +GR Sbjct: 135 HVSEITKLKFFPSGEALISSSQDM-QLKIWSVKDGSNPRTLIGHR--ATVTDIAIIDRGR 191 Query: 176 -LLSGSDDHTVALWEVGSG------GDPTKPVRTWNDLHSDIINDNKWHNF-----NKDL 223 +LS S D T+ LWE G+G P N + + D + H N Sbjct: 192 NVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLE 251 Query: 224 FGTVSE-------DSLLKINDVRANNTTIDTVKCPQPF----NTLAFSHHSSNLLAAAGM 272 FGT + ++ +++V + TI + P F N+L +++N + A Sbjct: 252 FGTYGKYVIAGHVSGVITVHNVFSKEQTI---QLPSKFTCSCNSLTVDGNNANYIYAGYE 308 Query: 273 DSYVYLYDLRNMKEPLHHMSGHEDA-VNNLEFSTHVDGVVVSSGSDNRLMM 322 + + +DLR+ + P+ +E +NN+ F+ + VSSG D + + Sbjct: 309 NGMLAQWDLRSPECPVGEFLINEGTPINNVYFA--AGALFVSSGFDTSIKL 357 >4V7E-Bg nrPDB Length = 380 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 19/72 (26%), Positives = 39/72 (54%), Gaps = 3/72 (4%) Query: 256 TLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSG 315 +L+ + ++N+ + D+ V L+DLR + GHE +N+++F DG +G Sbjct: 210 SLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKF--FPDGQRFGTG 267 Query: 316 SDN-RLMMWDLK 326 SD+ ++D++ Sbjct: 268 SDDGTCRLFDMR 279 >5WYK-BB nrPDB Length = 943 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 20/77 (25%), Positives = 38/77 (49%), Gaps = 5/77 (6%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKF--HKDNGYALSFSTLV 172 + H++ I +++PQ N + + V Y E + K H+ +AL+ +T Sbjct: 612 FAHQDSIMNVKFLPQSHNFFSC--SKDAVVKYWDGEKFECIQKLYAHQSEVWALAVAT-D 668 Query: 173 KGRLLSGSDDHTVALWE 189 G ++S S DH++ +WE Sbjct: 669 GGFVVSSSHDHSIRIWE 685 Score = 31.2 bits (69), Expect = 0.89, Method: Compositional matrix adjust. Identities = 22/107 (20%), Positives = 49/107 (45%), Gaps = 4/107 (3%) Query: 220 NKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY 279 + DL D ++K+ D+ + ++ L F + L++ + DS + ++ Sbjct: 90 DTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGS-KDSNIIVW 148 Query: 280 DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 DL + L+ + H+D++ F + ++S+ D + +WDLK Sbjct: 149 DLVG-EVGLYKLRSHKDSITG--FWCQGEDWLISTSKDGMIKLWDLK 192 >4L9O-A nrPDB Length = 349 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 31/132 (23%), Positives = 63/132 (47%), Gaps = 6/132 (4%) Query: 204 NDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTI--DTVKCPQPFNTLAFSH 261 + H D+I+D + + L T S D +KI ++ N + + P +A++H Sbjct: 65 GNAHDDLIHDAVLDYYGRRL-ATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAH 123 Query: 262 HSSN-LLAAAGMDSYVYLYDLRN-MKEPLHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDN 318 +LA+ D V ++ N + + S H+ +VN++ ++ H G V++ + SD Sbjct: 124 PKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDG 183 Query: 319 RLMMWDLKQIGA 330 ++ + + K GA Sbjct: 184 KISIVEFKDGGA 195 >3JAP-g nrPDB Length = 326 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 60/245 (24%), Positives = 103/245 (42%), Gaps = 32/245 (13%) Query: 152 LQSTLKFHKDNGYALSFSTLVK--GRLLSGSDDHTVALWEVGSGGDPTK-PVRTWNDLHS 208 L+ TL+ H NG+ S ST L+SGS D T+ W + PVR++ HS Sbjct: 10 LRGTLEGH--NGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKG-HS 66 Query: 209 DIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLA 268 I+ D + + + + S D L++ ++ N+ V ++A +SS +++ Sbjct: 67 HIVQDVV-VSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIIS 125 Query: 269 AAGMDSYVYLYDLRNMKEPLHHMSGHEDAVN-------NLEFSTHVDGVV--VSSGSDNR 319 A+ D + +++ + + + + GH D V NLE DG + VS+G D Sbjct: 126 AS-RDKTIRVWN--TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKI 182 Query: 320 LMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 + W L + D GH + +N +P L ASA ++ + V Sbjct: 183 VRSWSLNEDSYRIEAD------------FIGHNNYINVVQPSPDGS-LAASAGKDGQIYV 229 Query: 380 WKCSH 384 W H Sbjct: 230 WNLKH 234 >5FA5-B nrPDB Length = 367 Score = 33.1 bits (74), Expect = 0.23, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 8/75 (10%) Query: 263 SSNLLAAAG-MDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLM 321 SS A +G D + ++DL + L H V + S H D V +S DNR++ Sbjct: 160 SSGTQAVSGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRIL 218 Query: 322 MWDLK------QIGA 330 +WD + QIG Sbjct: 219 LWDTRCPKPASQIGC 233 >4U1E-I nrPDB Length = 347 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 42/228 (18%), Positives = 92/228 (40%), Gaps = 22/228 (9%) Query: 109 IRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSF 168 I++T HE +T+ +Y + + + YS + TL H +++ Sbjct: 4 IKLTG---HERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDV 60 Query: 169 STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWND-LHSDIINDNKWHNFNKDLFGTV 227 K ++GS D+++ LW+V +G + V TW + + + N+ + V Sbjct: 61 DCFTK-YCVTGSADYSIKLWDVSNG----QCVATWKSPVPVKRVEFSPCGNYFLAILDNV 115 Query: 228 SED-SLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG------------MDS 274 ++ + I ++ ++ T + K + +H + AG D Sbjct: 116 MKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDG 175 Query: 275 YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 + YD+ N E + + HE ++++++FS + + SS N ++ Sbjct: 176 KISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLV 223 >5BJS-A nrPDB Length = 605 Score = 32.3 bits (72), Expect = 0.34, Method: Compositional matrix adjust. Identities = 11/38 (28%), Positives = 22/38 (57%) Query: 343 ELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 +L GH +ND +P P+++ASA ++ +++W Sbjct: 169 KLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW 206 >5OPT-p nrPDB Length = 318 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 25/117 (21%), Positives = 56/117 (47%), Gaps = 20/117 (17%) Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMS--GHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMW 323 + + G D+ + +++++ E LH + H D V+ + FS ++ ++VS G DN + +W Sbjct: 124 IVSGGRDNALRVWNVKG--ECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVW 181 Query: 324 DLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 D+ L+ GH + + ++P L AS++++ + ++W Sbjct: 182 DIAS--------------GRLLTDLKGHTNYITSVTVSPDGS-LCASSDKDGVARLW 223 >3ODT-A nrPDB Length = 313 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%) Query: 155 TLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWN-DLHSDIIND 213 TL H+ N +LSF G ++SGS D T +W+ GS +N H+ + D Sbjct: 99 TLIGHQGNVCSLSFQ---DGVVISGSWDKTAKVWKEGS--------LVYNLQAHNASVWD 147 Query: 214 NKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMD 273 K +F+++ F T S D +K+ N+ I T + + D Sbjct: 148 AKVVSFSENKFLTASADKTIKL---WQNDKVIKTFSGIHNDVVRHLAVVDDGHFISCSND 204 Query: 274 SYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW-----DLKQI 328 + L D+ + + L GHE V ++ + D +VS G D + +W LKQ+ Sbjct: 205 GLIKLVDM-HTGDVLRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSLKQV 261 >6CB1-s nrPDB Length = 569 Score = 32.0 bits (71), Expect = 0.43, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 46/109 (42%), Gaps = 5/109 (4%) Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 II D K+H F LF V ++I D+ + + + + NL+A+ Sbjct: 403 IIMDAKFHPFKPQLF--VCSQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS 460 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDN 318 + D V +DL P + HE AV ++ F H + SS +D+ Sbjct: 461 S-FDKRVLWHDLDLASTPYKTLRYHEKAVRSVNF--HKKLPLFSSAADD 506 >2HES-X nrPDB Length = 330 Score = 32.0 bits (71), Expect = 0.49, Method: Compositional matrix adjust. Identities = 57/243 (23%), Positives = 97/243 (39%), Gaps = 38/243 (15%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDL------HSDIINDNKWHNFNKDLFGTVSE 229 L +GS D TV++W D T + DL H + + W N + T S Sbjct: 73 LAAGSFDSTVSIWAKEESADRTFEM----DLLAIIEGHENEVKGVAWSN-DGYYLATCSR 127 Query: 230 DSLLKINDVRANNTTIDTVKCPQPFN---TLAFSHHSSNLLAAAGMDSYVYLY-DLRNMK 285 D + I + + + + Q + H S LLA++ D V ++ D + Sbjct: 128 DKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDW 187 Query: 286 EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNR-LMMWDLKQIGAEQTPDDAEDGVPEL 344 E + ++GHE V + +F + SGSD+ + +W K +G ++ DD ++ V E Sbjct: 188 ECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVW--KYMGDDE--DDQQEWVCEA 243 Query: 345 IMVHAGHRSSVNDFDLNPQIPW----LVASAEEENILQV-------WKCSHSLPIVGGPP 393 I+ R N + W L+AS + +L V WK + G Sbjct: 244 ILPDVHKRQVYN-------VAWGFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVY 296 Query: 394 KVN 396 ++N Sbjct: 297 EIN 299 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 25/154 (16%) Query: 92 EEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFL---YSR 148 +E+GEEY+ I+ EH +++ + P + ++A+ + TV + Y Sbjct: 137 DESGEEYEC----------ISVLQEHSQDVKHVIWHPSEA-LLASSSYDDTVRIWKDYDD 185 Query: 149 SEGLQSTLKFHKDNGYALSF-STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWN--- 204 + L H+ ++ F T RL SGSDD TV +W+ GD + W Sbjct: 186 DWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKY--MGDDEDDQQEWVCEA 243 Query: 205 ---DLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 D+H + + W FN L +V D +L + Sbjct: 244 ILPDVHKRQVYNVAW-GFNG-LIASVGADGVLAV 275 >6EM1-m nrPDB Length = 807 Score = 31.6 bits (70), Expect = 0.70, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 46/109 (42%), Gaps = 5/109 (4%) Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 II D K+H F LF V ++I D+ + + + + NL+A+ Sbjct: 641 IIMDAKFHPFKPQLF--VCSQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS 698 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDN 318 + D V +DL P + HE AV ++ F H + SS +D+ Sbjct: 699 S-FDKRVLWHDLDLASTPYKTLRYHEKAVRSVNF--HKKLPLFSSAADD 744 >3JRP-A nrPDB Length = 379 Score = 31.6 bits (70), Expect = 0.71, Method: Compositional matrix adjust. Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 14/99 (14%) Query: 267 LAAAGMDSYVYLYDLRNMKEPL-HHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWD 324 LA D + ++++ L ++GHE V ++++ G +++S S D ++++W Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 85 Query: 325 LKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQ 363 E+G I VHA H +SVN P Sbjct: 86 ------------EENGRWSQIAVHAVHSASVNSVQWAPH 112 >4BZK-B nrPDB Length = 297 Score = 31.6 bits (70), Expect = 0.71, Method: Compositional matrix adjust. Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 14/99 (14%) Query: 267 LAAAGMDSYVYLYDLRNMKEPL-HHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWD 324 LA D + ++++ L ++GHE V ++++ G +++S S D ++++W Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 325 LKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQ 363 E+G I VHA H +SVN P Sbjct: 84 ------------EENGRWSQIAVHAVHSASVNSVQWAPH 110 >3JB9-g nrPDB Length = 558 Score = 31.2 bits (69), Expect = 0.83, Method: Compositional matrix adjust. Identities = 19/71 (26%), Positives = 36/71 (50%), Gaps = 3/71 (4%) Query: 255 NTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG-VVVS 313 + L F S +LL + MD+ + ++++ + + L GH + +L FS DG +S Sbjct: 270 SCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQ--DGRSFLS 327 Query: 314 SGSDNRLMMWD 324 + D + +WD Sbjct: 328 TSFDKTIKLWD 338 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 42/181 (23%), Positives = 71/181 (39%), Gaps = 28/181 (15%) Query: 155 TLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDN 214 T K H L F + LLSGS D+ + +WEV +RT+ H+ I D Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHD---RSLLRTFQG-HARPIRDL 316 Query: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSH--------HSSNL 266 + + T S D +K+ D KC FN+ ++ N Sbjct: 317 SFSQDGRSFLST-SFDKTIKLWDTELG-------KCLNCFNSDRLTNCVKFQVDPDKPNE 368 Query: 267 LAAAGMDSYVYLYDLRN---MKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 A D + +D+R+ ++ HH+ G +N++ F + V +S D+ + W Sbjct: 369 FLAGTADKRILQFDIRSPDIVQAYDHHLGG----INSITFLENGKRFVTTS-DDSSMRFW 423 Query: 324 D 324 + Sbjct: 424 E 424 >6C0F-s nrPDB Length = 807 Score = 31.2 bits (69), Expect = 0.85, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 46/109 (42%), Gaps = 5/109 (4%) Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 II D K+H F LF V ++I D+ + + + + NL+A+ Sbjct: 641 IIMDAKFHPFKPQLF--VCSQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS 698 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDN 318 + D V +DL P + HE AV ++ F H + SS +D+ Sbjct: 699 S-FDKRVLWHDLDLASTPYKTLRYHEKAVRSVNF--HKKLPLFSSAADD 744 >5CXC-A nrPDB Length = 510 Score = 31.2 bits (69), Expect = 0.86, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 53/127 (41%), Gaps = 6/127 (4%) Query: 226 TVSEDSLLKINDVRANNTTIDTVKCPQPF---NTLAFSHHSSNLLAAAGMDSYVYLYDLR 282 + S+D ++ D+ + T+ P + L + +S LLAA ++ + D R Sbjct: 330 SASQDHTVRTLDL-TTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPR 388 Query: 283 NMKEPLHHMS--GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDG 340 M+ GH + V +L S + +VS D +WDL+ + + + G Sbjct: 389 ASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGG 448 Query: 341 VPELIMV 347 V E + V Sbjct: 449 VSEPVYV 455 >4J0W-A nrPDB Length = 343 Score = 31.2 bits (69), Expect = 0.91, Method: Compositional matrix adjust. Identities = 38/172 (22%), Positives = 69/172 (40%), Gaps = 21/172 (12%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKG 174 + H++ + + ++ + A GTV ++ E +S L F+ G + + Sbjct: 148 FGHQDAVAALDALSRECCVTAG-GRDGTVRVWKIPE--ESQLVFYGHQGSIDCIHLINEE 204 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHS----DIINDNKWHN-----FNKDLFG 225 ++SG+DD +VALW G +P+ + H + W + N DL Sbjct: 205 HMVSGADDGSVALW----GLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVA 260 Query: 226 TVSEDSLLKINDVRANNTTIDTVKCPQPF----NTLAFSHHSSNLLAAAGMD 273 T S S +++ +D + C P N+L FS L+A G + Sbjct: 261 TGSHSSCVRLWQCGEGFRQLDLL-CDIPLVGFINSLKFSSSGDFLVAGVGQE 311 >3A22-A nrPDB Length = 614 Score = 30.8 bits (68), Expect = 0.96, Method: Compositional matrix adjust. Identities = 23/70 (32%), Positives = 29/70 (41%), Gaps = 5/70 (7%) Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAA----AGMDSYVYLYDLRNMKEPLHHMSGHE 295 A N T+DT + P + + HS L A AG D Y Y P GH Sbjct: 65 AGNITVDTAEWPGGMSAITAYIHSKGLKAGIYTDAGKDGCGYYYPTGRPAAPGSGSEGHY 124 Query: 296 DAVNNLEFST 305 D + L+FST Sbjct: 125 DQ-DMLQFST 133 >3JRO-A nrPDB Length = 753 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 24/98 (24%), Positives = 44/98 (44%), Gaps = 14/98 (14%) Query: 267 LAAAGMDSYVYLYDLRNMKEPL-HHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWD 324 LA D + ++++ L ++GHE V ++++ G +++S S D ++++W Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 325 LKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNP 362 E+G I VHA H +SVN P Sbjct: 84 ------------EENGRWSQIAVHAVHSASVNSVQWAP 109 >5MC9-A nrPDB Length = 633 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 11/90 (12%) Query: 187 LWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTID 246 LW++GSG T + IN+N+WH+ FG + S+ + + A N + Sbjct: 113 LWDLGSGS-------TRLEFPEVSINNNRWHSIYITRFGNMGSLSVKEASA--AENPPVR 163 Query: 247 TVKCPQPFNTLAFSHHSSNLLAAAGMDSYV 276 T K P P L ++S L+ G+ + Sbjct: 164 TSKSPGPSKVLDI--NNSTLMFVGGLGGQI 191 >6ELZ-p nrPDB Length = 460 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 52/105 (49%), Gaps = 7/105 (6%) Query: 226 TVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSS-NLLAAAGMDSYVYLYDLR-- 282 +VS+D +K D+ IDT ++ L+ + S+ NLLA ++ L+D R Sbjct: 305 SVSQDHTIKTWDL-VTARCIDTRTTS--YSLLSIAQLSTLNLLACGSSARHITLHDPRVG 361 Query: 283 -NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 + K + GH++ V++L+ + ++ S D + +WD++ Sbjct: 362 ASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVR 406 >4AEZ-A nrPDB Length = 401 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 32/126 (25%), Positives = 52/126 (41%), Gaps = 18/126 (14%) Query: 262 HSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLM 321 H + L+ + V +YD+ + + L M+GH+ V L ++ HV +SSGS + + Sbjct: 144 HDGSFLSVGLGNGLVDIYDVESQTK-LRTMAGHQARVGCLSWNRHV----LSSGSRSGAI 198 Query: 322 MWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 +I Q I GH S V L AS +N++Q+W Sbjct: 199 HHHDVRIANHQ------------IGTLQGHSSEVCGLAWRSDGLQL-ASGGNDNVVQIWD 245 Query: 382 CSHSLP 387 S+P Sbjct: 246 ARSSIP 251 >5L9T-R nrPDB Length = 493 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 6/61 (9%) Query: 267 LAAAGMDSYVYLYDLRNMKEPLH---HMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 L++ D + D+R PL + GH V L++ST ++ S G+DN+L++W Sbjct: 284 LSSGSRDRMILQRDIRT--PPLQSERRLQGHRQEVCGLKWSTD-HQLLASGGNDNKLLVW 340 Query: 324 D 324 + Sbjct: 341 N 341 Score = 28.5 bits (62), Expect = 5.7, Method: Compositional matrix adjust. Identities = 16/61 (26%), Positives = 33/61 (54%), Gaps = 3/61 (4%) Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSG--SDNRLMMW 323 LLA+ G D+ + +++ ++ P+ + H AV + +S H G++ S G +D + W Sbjct: 327 LLASGGNDNKLLVWNHSSL-SPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 385 Query: 324 D 324 + Sbjct: 386 N 386 >6EMK-B nrPDB Length = 303 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 43/181 (23%), Positives = 71/181 (39%), Gaps = 47/181 (25%) Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSD-------IINDNKWHNFNKDLFGTVS 228 L+S DHT+ WE +G V + HSD I ND K L T Sbjct: 5 LVSAGYDHTIRFWEALTG------VCSRTIQHSDSQVNRLEITNDKK-------LLATAG 51 Query: 229 EDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL-----------LAAAGMDSYVY 277 + +++ D+R N P P +F H N+ + + D + Sbjct: 52 HQN-VRLYDIRTTN--------PNPV--ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIK 100 Query: 278 LYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL--KQIGAEQTPD 335 ++D+R+ P ++ H VN + + G ++S D + +WDL Q + TP+ Sbjct: 101 VWDVRSPSIPRNYK--HNAPVNEVVIHPN-QGELISCDRDGNIRIWDLGENQCTHQLTPE 157 Query: 336 D 336 D Sbjct: 158 D 158 Score = 28.1 bits (61), Expect = 6.2, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 4/84 (4%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSE--GLQSTLKFHKDNGYALSF 168 +T H ITR + D +AT + T ++S + L++TL H+ + +F Sbjct: 200 VTKFRAHSTYITRI-LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAF 258 Query: 169 STLVKGRLLSGSDDHTVALWEVGS 192 S L++ S DH V LW++ + Sbjct: 259 SA-DSAYLVTASSDHYVRLWDLST 281 >5CXB-B nrPDB Length = 369 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 32/127 (25%), Positives = 54/127 (42%), Gaps = 16/127 (12%) Query: 261 HHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGV-VVSSGSDNR 319 H + L D + +DL P M H +A+ + F H G+ + + SD+ Sbjct: 251 HPGGDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRF--HKGGLPLFADASDDG 308 Query: 320 LMMWDLKQIGAEQTPDDAEDGVPELIMVH--AGHRS----SVNDFDLNPQIPWLVASAEE 373 + QI + P+D + P ++ V GH+ V D D +P+ PW V SA Sbjct: 309 SL-----QIFHGKVPNDQLEN-PTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCV-SAGA 361 Query: 374 ENILQVW 380 + ++W Sbjct: 362 DGTARLW 368 >6GMH-W nrPDB Length = 305 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 32/75 (42%), Gaps = 2/75 (2%) Query: 230 DSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH 289 D ++ I D+ P +L FS S LL A D Y+ +YD+++ Sbjct: 169 DGIINIFDIATGKLLHTLEGHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQHANLA-G 226 Query: 290 HMSGHEDAVNNLEFS 304 +SGH V N+ F Sbjct: 227 TLSGHASWVLNVAFC 241 >1OD4-A nrPDB Length = 805 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 7/75 (9%) Query: 140 QGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKG------RLLSGSDDHTVALWEVGSG 193 +G +LY SEG+++ KF K+N L+ T++ G + + GS+D GSG Sbjct: 223 KGFQYLYLTSEGMETLKKFDKENS-VLTERTVINGEERFVIKTIIGSEDGLGVECLRGSG 281 Query: 194 GDPTKPVRTWNDLHS 208 R ++D+ + Sbjct: 282 LIAGATSRAYHDIFT 296 >1IKQ-A nrPDB Length = 613 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 29/80 (36%), Positives = 34/80 (42%), Gaps = 16/80 (20%) Query: 122 TRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSD 181 R+ M DP I T NGQG + EG LK DN ALS + SD Sbjct: 23 VRSSRMSVDPAIADT-NGQGVLHYSMVLEGGNDALKLAIDN--ALSIT----------SD 69 Query: 182 DHTVALWEVGSGGDPTKPVR 201 T+ L G +P KPVR Sbjct: 70 GLTIRL---EGGVEPNKPVR 86 >4ON1-A nrPDB Length = 379 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 32/135 (23%), Positives = 58/135 (42%), Gaps = 18/135 (13%) Query: 147 SRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDL 206 S+ + + ++LKF D+G+ T+ G+ D+ V+ E +R+W+++ Sbjct: 222 SQIQAVTTSLKFLIDSGFITVKYTIKDSSHKGGASDYEVSALE-----SFQNYLRSWDEV 276 Query: 207 HSD------IINDNKWHNFNKDLFGTVSEDSLLKINDVRANN--TTIDTVKCPQPFNTLA 258 ++ D W + FG S ++ +N+ R N I T P+ TLA Sbjct: 277 KGQDKKPYILLRDGTWD--SGKTFGYASGIGVIHLNNPRGNFEVAAISTTSSSHPY-TLA 333 Query: 259 FSHHSSNLLAAAGMD 273 H +LL A +D Sbjct: 334 --HEIGHLLGAEHVD 346 >3EI3-B nrPDB Length = 383 Score = 28.5 bits (62), Expect = 5.9, Method: Compositional matrix adjust. Identities = 20/87 (22%), Positives = 38/87 (43%), Gaps = 11/87 (12%) Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 H+ V + EF+ D ++ +S D + +WDL+ I D + E+ H Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNI------KDKNSYIAEM-----PHEK 251 Query: 354 SVNDFDLNPQIPWLVASAEEENILQVW 380 VN NP + + ++ N ++V+ Sbjct: 252 PVNAAYFNPTDSTKLLTTDQRNEIRVY 278 Score = 28.1 bits (61), Expect = 6.3, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 26/41 (63%), Gaps = 2/41 (4%) Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSG--HEDAVNNLEFS 304 L+A + +D+ V L+DLRN+K+ +++ HE VN F+ Sbjct: 219 LMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFN 259 >4E5Z-B nrPDB Length = 436 Score = 28.1 bits (61), Expect = 6.4, Method: Compositional matrix adjust. Identities = 40/205 (19%), Positives = 79/205 (38%), Gaps = 29/205 (14%) Query: 179 GSDDHTVALWEVGSGGDPT--KPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 GS + LW G PT K + I K++ N + F S + ++ Sbjct: 138 GSKGGDIMLWNFGIKDKPTFIKGIGAGGS-----ITGLKFNPLNTNQFYASSMEGTTRLQ 192 Query: 237 DVRANNTTI----DTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNM-KEPLHHM 291 D + N + DT+ F +L S S ++ + + + L NM + L ++ Sbjct: 193 DFKGNILRVFASSDTINIW--FCSLDVSASSRMVVTGDNVGNVILL----NMDGKELWNL 246 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 H+ V ++ + D + ++ D + +WDL+Q+ + + + H Sbjct: 247 RMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKAS-----------FLYSLPH 295 Query: 352 RSSVNDFDLNPQIPWLVASAEEENI 376 R VN +P L+ + ++ I Sbjct: 296 RHPVNAACFSPDGARLLTTDQKSEI 320 >3DM0-A nrPDB Length = 694 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 41/162 (25%), Positives = 72/162 (44%), Gaps = 26/162 (16%) Query: 177 LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI- 235 LSGS D + LW++ +G + V D+ S + + N+ + + S D +K+ Sbjct: 446 LSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLD-----NRQIV-SASRDRTIKLW 499 Query: 236 NDVRANNTTI--------DTVKCPQPFNTLAFSHHSSN-LLAAAGMDSYVYLYDLRNMKE 286 N + TI D V C + FS ++ + +A D V +++L N K Sbjct: 500 NTLGECKYTISEGGEGHRDWVSCVR------FSPNTLQPTIVSASWDKTVKVWNLSNCKL 553 Query: 287 PLHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDLKQ 327 ++GH V+ + S DG + S G D +++WDL + Sbjct: 554 R-STLAGHTGYVSTVAVSP--DGSLCASGGKDGVVLLWDLAE 592 >6CVZ-A nrPDB Length = 351 Score = 28.1 bits (61), Expect = 7.0, Method: Compositional matrix adjust. Identities = 16/78 (20%), Positives = 36/78 (46%), Gaps = 1/78 (1%) Query: 206 LHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN 265 +H I + ++ + L + S D+ +K+ + NT + T +P + + +N Sbjct: 72 MHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLE-TNTVVQTYNAGRPVWSCCWCLDEAN 130 Query: 266 LLAAAGMDSYVYLYDLRN 283 + A + + +YD+RN Sbjct: 131 YIYAGLANGSILVYDVRN 148 >2ERO-A nrPDB Length = 427 Score = 28.1 bits (61), Expect = 7.3, Method: Compositional matrix adjust. Identities = 16/64 (25%), Positives = 34/64 (53%), Gaps = 3/64 (4%) Query: 278 LYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM---WDLKQIGAEQTP 334 +YD+ N+ P++H A+ LE ++ D ++V S +D L + W + + ++ Sbjct: 43 MYDIVNVITPIYHRMNIHVALVGLEIWSNTDKIIVQSSADVTLDLFAKWRATDLLSRKSH 102 Query: 335 DDAE 338 D+A+ Sbjct: 103 DNAQ 106 >5GLR-A nrPDB Length = 344 Score = 28.1 bits (61), Expect = 7.7, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 45/94 (47%), Gaps = 6/94 (6%) Query: 159 HKDNG-YALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 HK NG Y LS+ST ++ + D+ + G PV W + HS + + KW+ Sbjct: 248 HKYNGTYYLSYSTGDTHYIVYATGDNPYGPFTYR--GVILNPVIGWTNHHSIVEFNGKWY 305 Query: 218 NFNKD--LFGTVSEDSLLKINDVRAN-NTTIDTV 248 F D L G + +K+ ++ N + TI+T+ Sbjct: 306 LFYHDSSLSGGKTHLRCIKVTELTHNADGTIETI 339 >5A9Q-0 nrPDB Length = 380 Score = 27.7 bits (60), Expect = 8.9, Method: Compositional matrix adjust. Identities = 55/267 (20%), Positives = 98/267 (36%), Gaps = 43/267 (16%) Query: 110 RITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQS------TLKFHKDNG 163 ++ H ++ ++ Q+ + A+ G TVFL+ + S T +H G Sbjct: 66 QLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPG 125 Query: 164 YALSFSTLVKG------RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 S G +++ +D + L+ D + VRT ++ S ++ + Sbjct: 126 SPSYSSAPCTGVVCNNPEIVTVGEDGRINLFR----ADHKEAVRTIDNADSSTLHAVTFL 181 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNT--------TIDTVKCPQPFNTLAFSHHSSNLLAA 269 + L TV+ LKI D R T D V P + + + +++A Sbjct: 182 RTPEIL--TVNSIGQLKIWDFRQQGNEPSQILSLTGDRV----PLHCVDRHPNQQHVVAT 235 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG 329 G D + ++D+R P+ + HE + + F + + D L W Sbjct: 236 GGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHW------ 289 Query: 330 AEQTPDDAEDGVPEL-IMVHAGHRSSV 355 DA VPE + H G RSS Sbjct: 290 ------DASTDVPEKSSLFHQGGRSST 310 >5HQ2-K nrPDB Length = 483 Score = 27.7 bits (60), Expect = 9.9, Method: Compositional matrix adjust. Identities = 11/25 (44%), Positives = 14/25 (56%) Query: 317 DNRLMMWDLKQIGAEQTPDDAEDGV 341 DN+L+ W L Q G +D EDG Sbjct: 293 DNKLVSWGLNQFGQCGVSEDVEDGA 317 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4PSX-B nrPDB 574 e-164 5Y1U-A nrPDB 474 e-134 3CFV-B nrPDB 468 e-132 3C9C-A nrPDB 468 e-132 5WJC-A nrPDB 451 e-127 4XYI-A nrPDB 415 e-116 6QX9-4B nrPDB 243 1e-64 6QX9-5O nrPDB 226 1e-59 5MZH-A nrPDB 212 2e-55 6EOJ-D nrPDB 205 2e-53 6G51-g nrPDB 194 7e-50 4V6W-Ag nrPDB 190 1e-48 5NNZ-B nrPDB 182 2e-46 6HQA-B nrPDB 177 7e-45 5NZU-C nrPDB 175 2e-44 5FL8-q nrPDB 169 3e-42 5Y88-O nrPDB 164 6e-41 5WLC-LJ nrPDB 163 2e-40 4A11-B nrPDB 161 5e-40 3JB9-L nrPDB 159 2e-39 6N9G-C nrPDB 158 6e-39 4V8M-A7 nrPDB 156 2e-38 2PM9-A nrPDB 151 4e-37 3FM0-A nrPDB 150 8e-37 5OQL-d nrPDB 146 2e-35 5OQL-L nrPDB 145 4e-35 5WLC-LU nrPDB 116 2e-26 5OQL-J nrPDB 111 4e-25 2AQ5-A nrPDB 106 3e-23 3BG0-A nrPDB 104 7e-23 Sequences not found previously or not previously below threshold: 5M25-A nrPDB 171 5e-43 6MZM-G nrPDB 170 7e-43 6F3T-A nrPDB 170 8e-43 2H9P-A nrPDB 168 4e-42 3DM0-A nrPDB 168 5e-42 1VYH-C nrPDB 167 6e-42 5OPT-p nrPDB 150 1e-36 3MKQ-A nrPDB 138 4e-33 6HHQ-h nrPDB 138 5e-33 2YNP-A nrPDB 136 2e-32 5GAN-H nrPDB 134 8e-32 6ID0-T nrPDB 133 1e-31 5WYJ-BC nrPDB 133 2e-31 3JAP-g nrPDB 133 2e-31 4V7E-Bg nrPDB 131 8e-31 4BTS-AR nrPDB 128 4e-30 4YCZ-A nrPDB 119 2e-27 5UZ7-B nrPDB 117 6e-27 6Q8F-A nrPDB 117 7e-27 3W15-A nrPDB 116 1e-26 5K1B-B nrPDB 116 2e-26 5WLC-LO nrPDB 116 2e-26 5I2T-A nrPDB 115 4e-26 5Z56-q nrPDB 114 6e-26 6QDV-o nrPDB 114 6e-26 5YZG-W nrPDB 114 8e-26 2HES-X nrPDB 114 1e-25 4LG8-A nrPDB 113 1e-25 5WYK-BB nrPDB 112 3e-25 3JRO-A nrPDB 109 2e-24 5XYI-g nrPDB 106 1e-23 4AEZ-A nrPDB 106 1e-23 3ODT-A nrPDB 106 2e-23 5G04-R nrPDB 105 4e-23 4GGA-A nrPDB 104 6e-23 5FVM-C nrPDB 104 6e-23 5LCW-Q nrPDB 104 6e-23 5FA5-B nrPDB 103 1e-22 3JRP-A nrPDB 103 1e-22 4J0W-A nrPDB 102 2e-22 6ELZ-p nrPDB 101 4e-22 3JB9-g nrPDB 101 7e-22 4N14-A nrPDB 101 8e-22 4L9O-A nrPDB 101 9e-22 4BZK-B nrPDB 100 1e-21 5CXC-A nrPDB 100 1e-21 5L9T-R nrPDB 100 2e-21 6EMK-B nrPDB 98 6e-21 5A31-R nrPDB 98 8e-21 6GMH-W nrPDB 96 2e-20 4BH6-A nrPDB 96 3e-20 4G56-B nrPDB 93 2e-19 6J6H-n nrPDB 93 3e-19 5WBU-D nrPDB 91 9e-19 5A9Q-7 nrPDB 90 2e-18 5A9Q-0 nrPDB 89 2e-18 6CHG-A nrPDB 89 3e-18 5N4A-A nrPDB 89 4e-18 4XFV-A nrPDB 88 6e-18 6BX3-A nrPDB 87 1e-17 4U1E-I nrPDB 86 3e-17 1NR0-A nrPDB 84 8e-17 1PI6-A nrPDB 84 8e-17 3I2N-A nrPDB 84 8e-17 3JZG-A nrPDB 83 2e-16 4E5Z-B nrPDB 83 3e-16 3EI3-B nrPDB 83 3e-16 5K0Y-T nrPDB 82 5e-16 6F1U-h nrPDB 81 6e-16 5WYJ-BE nrPDB 81 9e-16 5A9Q-2 nrPDB 81 1e-15 3ACP-A nrPDB 80 1e-15 3F3P-A nrPDB 78 5e-15 5BJS-A nrPDB 77 1e-14 5MWJ-A nrPDB 76 4e-14 6CB1-s nrPDB 72 5e-13 6C0F-s nrPDB 72 6e-13 4OWR-A nrPDB 71 7e-13 6EM1-m nrPDB 71 1e-12 5CXB-B nrPDB 69 3e-12 5OQL-X nrPDB 68 1e-11 5K19-A nrPDB 66 3e-11 5OV3-A nrPDB 65 5e-11 6E29-D nrPDB 64 9e-11 3DW8-B nrPDB 61 8e-10 5WLC-SG nrPDB 59 4e-09 4J0X-A nrPDB 59 4e-09 5YZG-2 nrPDB 59 4e-09 6BX3-B nrPDB 59 4e-09 5TF2-A nrPDB 58 8e-09 5WLC-LW nrPDB 57 1e-08 5M89-A nrPDB 55 7e-08 5WLC-LN nrPDB 54 1e-07 6CHG-D nrPDB 54 1e-07 4FHN-A nrPDB 52 3e-07 5MC6-j nrPDB 50 2e-06 2P9P-C nrPDB 50 2e-06 6N8P-A nrPDB 47 2e-05 6CVZ-A nrPDB 46 3e-05 6IYY-A nrPDB 45 5e-05 3JB9-S nrPDB 45 7e-05 5WLC-LV nrPDB 43 2e-04 5AMS-A nrPDB 42 3e-04 2VDU-B nrPDB 41 0.001 2I3T-A nrPDB 40 0.002 5WLC-LH nrPDB 40 0.002 3DWL-C nrPDB 36 0.024 5WLC-LL nrPDB 34 0.10 5WLC-LS nrPDB 34 0.13 3OND-A nrPDB 31 0.79 4MDV-A nrPDB 31 0.92 4YHC-A nrPDB 31 1.1 5HQ2-K nrPDB 30 1.5 5GRS-A nrPDB 29 3.4 3V1X-A nrPDB 28 6.3 >4PSX-B nrPDB Length = 401 Score = 574 bits (1480), Expect = e-164, Method: Composition-based stats. Identities = 400/401 (99%), Positives = 400/401 (99%) Query: 1 MENQEKPLSVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELI 60 MENQEKPLSVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELI Sbjct: 1 MENQEKPLSVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELI 60 Query: 61 IGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEE 120 IGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEE Sbjct: 61 IGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEE 120 Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS 180 ITRARYMPQDPNIVATINGQGT FLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS Sbjct: 121 ITRARYMPQDPNIVATINGQGTTFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS 180 Query: 181 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRA 240 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRA Sbjct: 181 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRA 240 Query: 241 NNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNN 300 NNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNN Sbjct: 241 NNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNN 300 Query: 301 LEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL 360 LEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL Sbjct: 301 LEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL 360 Query: 361 NPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS 401 NPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS Sbjct: 361 NPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS 401 >5Y1U-A nrPDB Length = 456 Score = 474 bits (1219), Expect = e-134, Method: Composition-based stats. Identities = 145/393 (36%), Positives = 222/393 (56%), Gaps = 17/393 (4%) Query: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 ++EEY +WK N P +YD V L WPSLT QWLP + F L++GTHTS +E Sbjct: 48 INEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTS-DE 106 Query: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 +N+L A + LP + + ++ + + I I K HE E+ RARYMPQ Sbjct: 107 QNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQ 166 Query: 130 DPNIVATINGQGTVFLYSRSEGLQS-----------TLKFHKDNGYALSFSTLVKGRLLS 178 +P I+AT V ++ ++ L+ H+ GY LS++ + G LLS Sbjct: 167 NPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLS 226 Query: 179 GSDDHTVALWEVGSGGDPTKPV--RTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 SDDHT+ LW++ + K V +T H+ ++ D WH ++ LFG+V++D L I Sbjct: 227 ASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIW 286 Query: 237 DVRANNTTIDTVK---CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 D R+NNT+ + N L+F+ +S +LA D V L+DLRN+K LH Sbjct: 287 DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 346 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 H+D + +++S H + ++ SSG+D RL +WDL +IG EQ+P+DAEDG PEL+ +H GH + Sbjct: 347 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 406 Query: 354 SVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 ++DF NP PW++ S E+NI+QVW+ + ++ Sbjct: 407 KISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 439 >3CFV-B nrPDB Length = 414 Score = 468 bits (1205), Expect = e-132, Method: Composition-based stats. Identities = 142/393 (36%), Positives = 222/393 (56%), Gaps = 17/393 (4%) Query: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 ++EEY +WK N P +YD V L WPSLTVQWLP + + L++GTHTS +E Sbjct: 19 INEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTS-DE 77 Query: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 +N+L A +++P + + ++ + + I K HE E+ RARYMPQ Sbjct: 78 QNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQ 137 Query: 130 DPNIVATINGQGTVFLYSRSEGLQS-----------TLKFHKDNGYALSFSTLVKGRLLS 178 +P+I+AT V ++ ++ L+ H+ GY LS+++ + G LLS Sbjct: 138 NPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLS 197 Query: 179 GSDDHTVALWEVGSGGDPTKPV--RTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 SDDHTV LW++ +G K V + HS ++ D WH ++ LFG+V++D L I Sbjct: 198 ASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIW 257 Query: 237 DVRANNTTIDTV---KCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 D R+N T+ + N L+F+ +S +LA D V L+DLRN+K LH Sbjct: 258 DTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFES 317 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 H+D + + +S H + ++ SSG+D RL +WDL +IG EQ+ +DAEDG PEL+ +H GH + Sbjct: 318 HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTA 377 Query: 354 SVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 ++DF NP PW++ S E+NI+Q+W+ + ++ Sbjct: 378 KISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 410 >3C9C-A nrPDB Length = 432 Score = 468 bits (1204), Expect = e-132, Method: Composition-based stats. Identities = 140/393 (35%), Positives = 218/393 (55%), Gaps = 17/393 (4%) Query: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 ++EEY +WK N P +YD V L WPSLT QWLP ++ + LI+GTHTS +E Sbjct: 23 INEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTS-DE 81 Query: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 +N+L A + LP E + + + + I I K HE E+ RARYMPQ Sbjct: 82 QNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQ 141 Query: 130 DPNIVATINGQGTVFLYSRSEGLQS-----------TLKFHKDNGYALSFSTLVKGRLLS 178 + ++AT V ++ ++ L+ H+ GY LS++ + G LLS Sbjct: 142 NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLS 201 Query: 179 GSDDHTVALWEVGSGGDPTKPV--RTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 SDDHT+ LW++ + + + + H+ ++ D WH ++ LFG+V++D L I Sbjct: 202 ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW 261 Query: 237 DVRANNTTIDTVK---CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 D R NNT+ + N L+F+ +S +LA D V L+DLRN+K LH Sbjct: 262 DTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES 321 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 H+D + +++S H + ++ SSG+D RL +WDL +IG EQ+ +DAEDG PEL+ +H GH + Sbjct: 322 HKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTA 381 Query: 354 SVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 ++DF NP PW++ S E+NI+QVW+ + ++ Sbjct: 382 KISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 414 >5WJC-A nrPDB Length = 430 Score = 451 bits (1159), Expect = e-127, Method: Composition-based stats. Identities = 143/395 (36%), Positives = 221/395 (55%), Gaps = 20/395 (5%) Query: 9 SVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGE 68 ++ EEY LWK NVP +YD V L WPSLT+QWLP + Q LI+GTHTSG Sbjct: 25 TIQEEYKLWKQNVPFLYDLVITHALEWPSLTIQWLPDKKTIPGTDYSIQRLILGTHTSGN 84 Query: 69 EENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMP 128 ++NYL+ A + LP +ED E + + I I+ K H+ ++ RARYMP Sbjct: 85 DQNYLQIASVQLPN---FDEDTTEFTPSTIRRAQATGSYTIEISQKIPHDGDVNRARYMP 141 Query: 129 QDPNIVATINGQGTVFLYSRSEG---------LQSTLKFHKDNGYALSFSTLVKGRLLSG 179 Q P I+AT+ G +++ + Q+ LK H G+ L ++ + G L +G Sbjct: 142 QKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATG 201 Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDL-----HSDIINDNKWHNFNKDLFGTVSEDSLLK 234 ++D + LW+V + + + + + H+DI+ND ++H ++ L +VS+D L+ Sbjct: 202 AEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQ 261 Query: 235 INDVRAN--NTTIDTVK-CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 I+D R N ++ + N +A + + LLA A D V L+DLRN + LH + Sbjct: 262 IHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTL 321 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 GHED V LE+S H + ++ SS +D R+ +WDL++IG EQTP+DAEDG PEL+ +H GH Sbjct: 322 EGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGH 381 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 + +++F P W+V S ++NILQ+W S + Sbjct: 382 TNRISEFSWCPNERWVVGSLADDNILQIWSPSRVI 416 >4XYI-A nrPDB Length = 430 Score = 415 bits (1066), Expect = e-116, Method: Composition-based stats. Identities = 136/396 (34%), Positives = 226/396 (57%), Gaps = 24/396 (6%) Query: 10 VDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEE 69 + EEY LWK NVP +YD V L WPSLTV+W P + L Q+L++GT TSG + Sbjct: 26 IQEEYKLWKQNVPFLYDLVITEALEWPSLTVEWFPGSERSLADNSSIQKLLLGTQTSGND 85 Query: 70 ENYLKFAEINLPK--EILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYM 127 +NYL+ A + LP + L + P + ++ + I K HE ++ +AR+M Sbjct: 86 QNYLQVASVQLPTFDDDLDDLTPSKMKPANFKGDYG-----LDIVQKIHHEGDVNKARFM 140 Query: 128 PQDPNIVATINGQGTVFLYS---------RSEGLQSTLKFHKDNGYALSFSTLVKGRLLS 178 PQ+P+I+AT+ G +++ G Q+ L+ H G+ L ++ + +G L + Sbjct: 141 PQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLGWNFIQEGTLAT 200 Query: 179 GSDDHTVALWEVGSGGDPTKPVRTWNDL-----HSDIINDNKWHNFNKDLFGTVSEDSLL 233 G++D ++ +W++ + + H+ ++ND ++H ++ L +VS+D L Sbjct: 201 GTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTL 260 Query: 234 KINDVR--ANNTTIDTVK-CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHH 290 +I+D R ++++ VK QP N +AF+ + LLA A D V L+DLR + + LH Sbjct: 261 QIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHT 320 Query: 291 MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 + GHED V N+++S H + ++V+S +D R+ +WDL +IG EQT +D+EDG PEL+ +H G Sbjct: 321 LEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGG 380 Query: 351 HRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 H + V+D NP W++AS ++NILQ+W S + Sbjct: 381 HTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVI 416 >6QX9-4B nrPDB Length = 522 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 124/333 (37%), Gaps = 44/333 (13%) Query: 68 EEENYLKFAEI-----NLPKEI-------LSNEDPQEEAGEEYQSSLPAPRSNIRITAKY 115 E N LK A + +LP+ + L E P+ + Q + RS ++ Sbjct: 169 EGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQI 228 Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSE-GLQSTLKFHKDNGYALSFSTLV-- 172 + I+ + P + ++AT G L+S + L TL+ H N A+ F Sbjct: 229 GDDRPISYCHFSP-NSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTV 287 Query: 173 -----KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTV 227 L S + D +V LW + D +PV H+ + WH + GT Sbjct: 288 SLDPKDVNLASCAADGSVKLWSL----DSDEPVADIEG-HTVRVARVMWHPSGR-FLGTT 341 Query: 228 SEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEP 287 D ++ D+ A + +AF H +L G+D++ ++DLR + Sbjct: 342 CYDRSWRLWDLEAQEEILHQEGHSMGVYDIAF-HQDGSLAGTGGLDAFGRVWDLRTGR-C 399 Query: 288 LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMV 347 + + GH + + FS + + SG DN +WDL+Q + Sbjct: 400 IMFLEGHLKEIYGINFSPNGYHIATGSG-DNTCKVWDLRQR--------------RCVYT 444 Query: 348 HAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 H++ V P + + +N ++W Sbjct: 445 IPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW 477 Score = 41.3 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 13/103 (12%), Positives = 34/103 (33%), Gaps = 22/103 (21%) Query: 293 GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHR 352 G + ++ FS + ++ ++ +W + L+ GH Sbjct: 229 GDDRPISYCHFSPNS-KMLATACWSGLCKLWSV--------------PDCNLLHTLRGHN 273 Query: 353 SSVNDFDLNPQIPWLV-------ASAEEENILQVWKCSHSLPI 388 ++V +P+ + AS + +++W P+ Sbjct: 274 TNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPV 316 >6QX9-5O nrPDB Length = 357 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 133/322 (41%), Gaps = 54/322 (16%) Query: 93 EAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGL 152 +AG SSL AP I HE E+ ++ P + + +A+ + L++ Sbjct: 46 QAGPPRCSSLQAP-----IMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVYGDC 99 Query: 153 Q--STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI 210 +TLK H L ++T L S S D TVA+W+ +G + H+ Sbjct: 100 DNYATLKGHSGAVMELHYNT-DGSMLFSASTDKTVAVWDSETGERVKRL-----KGHTSF 153 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 +N L T S+D +K+ D+R I T + + F+ +S+ + + Sbjct: 154 VNSCYPARRGPQLVCTGSDDGTVKLWDIR-KKAAIQTFQNTYQVLAVTFN-DTSDQIISG 211 Query: 271 GMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGA 330 G+D+ + ++DLR K + M GH D+V L S+ ++S+ DN + +WD++ Sbjct: 212 GIDNDIKVWDLRQNKL-TYTMRGHADSVTGLSLSSEG-SYLLSNAMDNTVRVWDVRPFAP 269 Query: 331 EQ----------------------TPDDAE-------------DGVPELIMVHA-GHRSS 354 ++ +PD ++ D I+ GH S Sbjct: 270 KERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGS 329 Query: 355 VNDFDLNPQIPWLVASAEEENI 376 +N+ +P P +++++ ++ + Sbjct: 330 INEVAFHPDEPIIISASSDKRL 351 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 29/146 (19%), Positives = 54/146 (36%), Gaps = 16/146 (10%) Query: 243 TTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLE 302 + F + S LA+AG D + L+++ + + GH AV L Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELH 116 Query: 303 FSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNP 362 ++T ++ S+ +D + +WD E + GH S VN Sbjct: 117 YNT-DGSMLFSASTDKTVAVWD--------------SETGERVKRLKGHTSFVNSCYPAR 161 Query: 363 QIPWLVASAEEENILQVWKCSHSLPI 388 + P LV + ++ +++W I Sbjct: 162 RGPQLVCTGSDDGTVKLWDIRKKAAI 187 >5MZH-A nrPDB Length = 452 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 116/295 (39%), Gaps = 40/295 (13%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTLKFHKDNGYALSFSTLVKGR 175 H +T + + + T + T +++ + TL+ HK+ YA++F+ + Sbjct: 93 HILPLTNCAFN-KSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDK 151 Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 +++GS D T LW+ +G + T ++I+ + N + T S D+ K+ Sbjct: 152 IVTGSFDKTCKLWDAYTG----QLYYTLKGHQTEIVCLS--FNPQSTIIATGSMDNTAKL 205 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHE 295 DV +L F+ +L+ D L+D+R + +H +SGH Sbjct: 206 WDVETGQERATLAGHRAEIVSLGFN-TGGDLIVTGSFDHDSRLWDVRT-GQCVHVLSGHR 263 Query: 296 DAVNNLEFSTHVDGVVVSSGSDNRLMMWD--------LKQIGAEQTPDDAEDGVPELIM- 346 V++ +F+ + +VVS D +WD +KQ ++ D A D ++ Sbjct: 264 GEVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVS 322 Query: 347 -------------------VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 GH ++ NPQ L+ +A + ++W C Sbjct: 323 ASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLI-TASSDKTCRLWDC 376 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 112/284 (39%), Gaps = 28/284 (9%) Query: 99 QSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQ-STLK 157 A + T K H+ EI + PQ I+AT + T L+ G + +TL Sbjct: 161 CKLWDAYTGQLYYTLK-GHQTEIVCLSFNPQ-STIIATGSMDNTAKLWDVETGQERATLA 218 Query: 158 FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 H+ +L F+T +++GS DH LW+V +G + V + H ++ ++ Sbjct: 219 GHRAEIVSLGFNT-GGDLIVTGSFDHDSRLWDVRTG----QCVHVLSG-HRGEVSSTQF- 271 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVY 277 N+ L + S D ++ DVR+ +AF + + +A D Sbjct: 272 NYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFD-AAGTKMVSASADGSAR 330 Query: 278 LYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDA 337 LY H + GHE ++ + F+ ++++ SD +WD Sbjct: 331 LYHTLT-GVCQHTLVGHEGEISKVAFNPQG-TRLITASSDKTCRLWDCD----------- 377 Query: 338 EDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 E + V GH + N + +++ + ++N ++WK Sbjct: 378 ---TGECLQVLEGHTDEIFSCAFNYEGDFII-TGSKDNTCRIWK 417 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 45/117 (38%), Gaps = 5/117 (4%) Query: 83 EILSNEDPQEEAGEEYQSSLPAPRSNIRITA--KYEHEEEITRARYMPQDPNIVATINGQ 140 ++ + + S + + HE EI++ + PQ ++ T + Sbjct: 310 DVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLI-TASSD 368 Query: 141 GTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDP 196 T L+ G L+ H D ++ +F+ +++GS D+T +W+ + Sbjct: 369 KTCRLWDCDTGECLQVLEGHTDEIFSCAFN-YEGDFIITGSKDNTCRIWKALTASSQ 424 >6EOJ-D nrPDB Length = 470 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 113/292 (38%), Gaps = 23/292 (7%) Query: 96 EEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQST 155 S A + H+ +T +Y D + + + + G + ++ + + Sbjct: 114 SGEFSLWNASSFTFETLMQ-AHDSAVTTMKYS-HDSDWMISGDADGMIKIWQPNFSMVKE 171 Query: 156 L-KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDN 214 + H ++ ++FS+ + ++ SDD+ + +W +G K R + H D + Sbjct: 172 IDAAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNG----KQERVLSGHHWD-VKSC 225 Query: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS 274 WH L + S+D+L+K+ D R+ N +K F NLL A D Sbjct: 226 DWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDK 284 Query: 275 YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTP 334 ++D+R + L + D + LE+ + + + D L +DL Q E Sbjct: 285 SCRVFDIRYSMKELMCVRDETDYM-TLEWHPINESMFTLACYDGSLKHFDLLQNLNE--- 340 Query: 335 DDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 ++ + H + NP + + A+A ++ ++ W + + Sbjct: 341 --------PILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTIRFWTRARPI 383 >6G51-g nrPDB Length = 317 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 58/275 (21%), Positives = 115/275 (41%), Gaps = 36/275 (13%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG------LQSTLKFHKDNGYALSFS 169 H +T+ PQ P+++ + + T+ ++ + Q L+ H + S Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 Query: 170 TLVKGRL-LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVS 228 + G+ LSGS D T+ LW++ +G + V H+ + + + N+ + + S Sbjct: 73 S--DGQFALSGSWDGTLRLWDLTTGTTTRRFV-----GHTKDVLSVAFSSDNRQIV-SGS 124 Query: 229 EDSLLKIND-VRANNTTIDTVKCPQPFNTLAFSHHSSN-LLAAAGMDSYVYLYDLRNMKE 286 D +K+ + + T+ + + + FS +SSN ++ + G D V +++L N K Sbjct: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 Query: 287 PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIM 346 +H+ GH +N + S + S G D + M+WDL + T D + Sbjct: 185 KTNHI-GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI------- 235 Query: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 +N +P WL A+ +++W Sbjct: 236 --------INALCFSPNRYWLCAATGP--SIKIWD 260 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 46/239 (19%), Positives = 94/239 (39%), Gaps = 18/239 (7%) Query: 147 SRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDL 206 + L+ TLK H ++ + +LS S D T+ +W++ + Sbjct: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL 266 HS ++D + + + S D L++ D+ TT V + ++AFS + Sbjct: 62 HSHFVSDV-VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS-SDNRQ 119 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTH-VDGVVVSSGSDNRLMMWDL 325 + + D + L++ + + H + V+ + FS + + ++VS G D + +W+L Sbjct: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 Query: 326 KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 +L H GH +N ++P L AS ++ +W + Sbjct: 180 --------------ANCKLKTNHIGHTGYLNTVTVSPDGS-LCASGGKDGQAMLWDLNE 223 Score = 35.5 bits (80), Expect = 0.046, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 19/48 (39%) Query: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPK 394 GH V PQ P ++ SA + + +WK + G P + Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR 57 >4V6W-Ag nrPDB Length = 318 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 108/279 (38%), Gaps = 35/279 (12%) Query: 114 KYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-------LQSTLKFHKDNGYAL 166 H +T+ P+DP+ + + + T+ ++ + Q L H + Sbjct: 11 LIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDV 70 Query: 167 SFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGT 226 S+ LSGS D T+ LW++ +G + + H+ + + N+ + + Sbjct: 71 VLSS-DGNYALSGSWDQTLRLWDLAAGKTTRRF-----EGHTKDVLSVAFSADNRQIV-S 123 Query: 227 VSEDSLLKIND-VRANNTTIDTVKCPQPFNTLAFSH-HSSNLLAAAGMDSYVYLYDLRNM 284 S D +K+ + + TI + + FS HS+ ++ + G D V +++L N Sbjct: 124 GSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANC 183 Query: 285 KEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 K +H GH +N + S + S G D++ ++WDL T + Sbjct: 184 KLKNNHH-GHNGYLNTVTVSP-DGSLCTSGGKDSKALLWDLNDGKNLYTLE--------- 232 Query: 345 IMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 H +N +P WL + +++W + Sbjct: 233 ------HNDIINALCFSPNRYWLCVAYGP--SIKIWDLA 263 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 49/237 (20%), Positives = 95/237 (40%), Gaps = 19/237 (8%) Query: 147 SRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPV-RTWND 205 S + L+ TL H ++ + ++S S D T+ +W++ D + Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 206 LHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN 265 HS I+D + + + + S D L++ D+ A TT + ++AFS + Sbjct: 62 GHSHFISDV-VLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFS-ADNR 119 Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFST-HVDGVVVSSGSDNRLMMWD 324 + + D + L++ + GH D V+ + FS H + ++VS G D + +W+ Sbjct: 120 QIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWN 179 Query: 325 LKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 L +L H GH +N ++P L S +++ +W Sbjct: 180 L--------------ANCKLKNNHHGHNGYLNTVTVSPDGS-LCTSGGKDSKALLWD 221 Score = 35.9 bits (81), Expect = 0.029, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 19/48 (39%) Query: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPK 394 GH V NP+ P + SA + L VWK + G P+ Sbjct: 10 TLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQ 57 >5NNZ-B nrPDB Length = 415 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 59/338 (17%), Positives = 120/338 (35%), Gaps = 49/338 (14%) Query: 83 EILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEE---ITRARYMP-------QDPN 132 E + +P A Q L R ++ H + +A +P + + Sbjct: 46 EEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGS 105 Query: 133 IVATINGQGTVFLYSRSEGL-QSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVG 191 T + T L+ + G +TL+ H++ YA++F+ ++ +GS D T LW V Sbjct: 106 CFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE 165 Query: 192 SGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCP 251 +G K T+ H+ I ++ + L T S D+ K+ D++ Sbjct: 166 TG----KCYHTFRG-HTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQNGEEVYTLRGHS 219 Query: 252 QPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVV 311 +L+F+ S + + D V ++D + ++ + GH +++ F+ ++ Sbjct: 220 AEIISLSFN-TSGDRIITGSFDHTVVVWD-ADTGRKVNILIGHCAEISSASFN-WDCSLI 276 Query: 312 VSSGSDNRLMMWDLKQIGAEQTPDDAED----------------------------GVPE 343 ++ D +WD T +D + Sbjct: 277 LTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRK 336 Query: 344 LIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 I GH ++ NPQ L+ + + ++W Sbjct: 337 CIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWD 373 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 104/266 (39%), Gaps = 27/266 (10%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGL-QSTLKFHKDNGYALSFSTLVKG 174 H EI + PQ +VAT + T L+ G TL+ H +LSF+T Sbjct: 175 GHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTS-GD 232 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 R+++GS DHTV +W+ +G + H I+ + N++ L T S D K Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILI-----GHCAEISSASF-NWDCSLILTGSMDKTCK 286 Query: 235 INDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH 294 + D F ++ L+A A D ++ ++ + + GH Sbjct: 287 LWDATNGKCVATLTGHDDEILDSCFD-YTGKLIATASADGTARIFSAAT-RKCIAKLEGH 344 Query: 295 EDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSS 354 E ++ + F+ + +++ SD +WD + + + V GH Sbjct: 345 EGEISKISFNPQGNH-LLTGSSDKTARIWDAQ--------------TGQCLQVLEGHTDE 389 Query: 355 VNDFDLNPQIPWLVASAEEENILQVW 380 + N + +V + ++N ++W Sbjct: 390 IFSCAFNYKGN-IVITGSKDNTCRIW 414 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 49/298 (16%), Positives = 103/298 (34%), Gaps = 36/298 (12%) Query: 98 YQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFL------------ 145 ++ +++ Q + T + V L Sbjct: 18 EYEKHGELKTKSIDLLDLGPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQN 77 Query: 146 YSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWND 205 + + L LK H ++ + ++GS D T LW+ SG + + Sbjct: 78 SNHTFYLFKVLKAHILPLTNVALN-KSGSCFITGSYDRTCKLWDTASGEELNTL-----E 131 Query: 206 LHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN 265 H +++ ++N D T S D K+ V L+F+ S+ Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST- 190 Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 L+A MD+ L+D++N E ++ + GH + +L F+T D ++ D+ +++WD Sbjct: 191 LVATGSMDTTAKLWDIQN-GEEVYTLRGHSAEIISLSFNTSGDRIIT-GSFDHTVVVWD- 247 Query: 326 KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 + + GH + ++ N L+ + + ++W + Sbjct: 248 -------------ADTGRKVNILIGHCAEISSASFNWDCS-LILTGSMDKTCKLWDAT 291 >6HQA-B nrPDB Length = 722 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 63/273 (23%), Positives = 114/273 (41%), Gaps = 21/273 (7%) Query: 66 SGEEENYLKFAEIN-LPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRA 124 SG +++++K I+ P L DP + + + + R H + Sbjct: 407 SGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRR-------LVGHSGAVYGV 459 Query: 125 RYMPQDPNIVATINGQGTVFLYSRSE-GLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDH 183 + P + + + + TV L+S + K H + + + FS + + S D Sbjct: 460 DFSPDN-RYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM-GHYFATASHDQ 517 Query: 184 TVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNT 243 T LW D P+R + H + ++ ++H + LF T S D ++ D+ Sbjct: 518 TARLWSC----DHIYPLRIFAG-HLNDVDCVEFHPNSTYLF-TGSSDKTARMWDIARGEC 571 Query: 244 TIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH-EDAVNNLE 302 + N LA S LA+AG DS V L+D+ + + M GH ++ +L Sbjct: 572 VRVFMGHSGAINCLAVSP-DGRWLASAGEDSVVCLWDISTGRR-IKAMRGHGRSSIYSLA 629 Query: 303 FSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD 335 FS V+VS+G+DN + +WD+K+ + Sbjct: 630 FS-REGTVLVSTGADNSVRVWDVKKNTNSPSAQ 661 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 110/320 (34%), Gaps = 51/320 (15%) Query: 69 EENYLKFAEINLP---KEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHE--EEITR 123 +EN + LP + L N+ + A S + H ++T Sbjct: 336 DENNPSKDTLPLPLKSAQDLRNDIAMIQDSRAKIKLSAAQASLPSVCMYTFHNTNNDLTC 395 Query: 124 ARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDH 183 ++ D +VA+ + L+S +L + G + GS Sbjct: 396 LKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQ-----NNDGVAVKGS--- 446 Query: 184 TVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNT 243 + V HS + + N+ L + SED +++ + Sbjct: 447 -------------RRLV-----GHSGAVYGVDFSPDNRYLI-SCSEDKTVRLWSLDTYTC 487 Query: 244 TIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEF 303 + + FS + A A D L+ ++ PL +GH + V+ +EF Sbjct: 488 LVSYKGHSSSVWDVKFSPM-GHYFATASHDQTARLWSCDHIY-PLRIFAGHLNDVDCVEF 545 Query: 304 STHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQ 363 + + + SD MWD+ + E + V GH ++N ++P Sbjct: 546 HPNS-TYLFTGSSDKTARMWDIAR--------------GECVRVFMGHSGAINCLAVSPD 590 Query: 364 IPWLVASAEEENILQVWKCS 383 WL ASA E++++ +W S Sbjct: 591 GRWL-ASAGEDSVVCLWDIS 609 >5NZU-C nrPDB Length = 905 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 52/266 (19%), Positives = 111/266 (41%), Gaps = 27/266 (10%) Query: 121 ITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSG 179 + P +P ++A++ G+V +++ ++ L T + A F K +++G Sbjct: 18 VKSVDLHPTEPWMLASL-YNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVAR-KNWVVTG 75 Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVR 239 +DD + ++ + + HSD I H + T S+D L+K+ D Sbjct: 76 ADDMQIRVFNYNTLERV-----HMFEAHSDYIRCIAVHP-TQPFILTSSDDMLIKLWDWD 129 Query: 240 ANNTTID-TVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAV 298 + + + +N A+A +D + ++ L P + GHE V Sbjct: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQL-GSSSPNFTLEGHEKGV 188 Query: 299 NNLEFSTHVDGVVVSSGSDNR-LMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVND 357 N +++ + D + SG+D+R + +WD + QT + GH +V+ Sbjct: 189 NCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLE--------------GHAQNVSC 234 Query: 358 FDLNPQIPWLVASAEEENILQVWKCS 383 +P++P ++ + E+ +++W S Sbjct: 235 ASFHPELP-IIITGSEDGTVRIWHSS 259 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 28/188 (14%), Positives = 62/188 (32%), Gaps = 9/188 (4%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSE--GLQSTLKFHKDNGYALSFSTLVKG 174 H + I P P I+ T + + L+ + + H + + Sbjct: 98 HSDYIRCIAVHPTQPFIL-TSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNN 156 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 + S S D T+ +W++GS P T + + + +K + ++D L+K Sbjct: 157 QFASASLDRTIKVWQLGSSS----PNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVK 212 Query: 235 INDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH 294 I D + Q + +F ++ D V ++ + ++ Sbjct: 213 IWDYQNKTCVQTLEGHAQNVSCASFHPELP-IIITGSEDGTVRIWHSSTYRLES-TLNYG 270 Query: 295 EDAVNNLE 302 + V + Sbjct: 271 MERVWCVA 278 Score = 94.9 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 33/165 (20%), Positives = 63/165 (38%), Gaps = 9/165 (5%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTLKFHKDNGYAL-SFSTLVK 173 H + + P+D N A+ + T+ ++ S TL+ H+ + +S K Sbjct: 140 GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDK 199 Query: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 L+SG+DD V +W+ V+T H+ ++ +H + T SED + Sbjct: 200 PYLISGADDRLVKIWD----YQNKTCVQTLEG-HAQNVSCASFHPELP-IIITGSEDGTV 253 Query: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYL 278 +I + +A S SN +A + + + Sbjct: 254 RIWHSSTYRLESTLNYGMERVWCVA-SLRGSNNVALGYDEGSIIV 297 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 30/188 (15%), Positives = 60/188 (31%), Gaps = 17/188 (9%) Query: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAF 259 ++ SD + H + ++ + + + + C P F Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLASL-YNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65 Query: 260 SHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNR 319 N + D + +++ + E +H H D + + +++S D Sbjct: 66 VARK-NWVVTGADDMQIRVFNYNTL-ERVHMFEAHSDYIRCIAVHPT-QPFILTSSDDML 122 Query: 320 LMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 + +WD D V GH V +NP+ ASA + ++V Sbjct: 123 IKLWD-------------WDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKV 169 Query: 380 WKCSHSLP 387 W+ S P Sbjct: 170 WQLGSSSP 177 >5M25-A nrPDB Length = 434 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 49/281 (17%), Positives = 120/281 (42%), Gaps = 30/281 (10%) Query: 105 PRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLY-SRSEGLQSTLKFHKDNG 163 P ++ T H + ++ ++ P + +A+ + + ++ + + T+ HK Sbjct: 133 PNYALKFTL-AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 190 Query: 164 YALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDL 223 +++S+ L+S SDD T+ +W+V SG K ++T HS+ + ++ +L Sbjct: 191 SDVAWSS-DSNLLVSASDDKTLKIWDVSSG----KCLKTLKG-HSNYVFCCNFNPQ-SNL 243 Query: 224 FGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN 283 + S D ++I DV+ P + + F+ +L+ ++ D ++D Sbjct: 244 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDT-A 301 Query: 284 MKEPLHHMSGHED-AVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVP 342 + L + ++ V+ ++FS + ++ ++ DN L +WD + Sbjct: 302 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK--------------G 346 Query: 343 ELIMVHAGHRSSVNDF--DLNPQIPWLVASAEEENILQVWK 381 + + + GH++ + + + S E+N++ +W Sbjct: 347 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 387 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 120/273 (43%), Gaps = 29/273 (10%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVK 173 H+ I+ + D N++ + + T+ ++ S G TLK H + + +F+ Sbjct: 184 SGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QS 241 Query: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 ++SGS D +V +W+V +G K ++T HSD ++ + N + L + S D L Sbjct: 242 NLIVSGSFDESVRIWDVKTG----KCLKTLP-AHSDPVSAVHF-NRDGSLIVSSSYDGLC 295 Query: 234 KINDVRANNTTIDTVKCPQ-PFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 +I D + + P + + FS + +LA A +D+ + L+D + + L + Sbjct: 296 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDY-SKGKCLKTYT 353 Query: 293 GHEDAVNNL--EFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 GH++ + FS +VS DN + +W+L+ E++ G Sbjct: 354 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ--------------TKEIVQKLQG 399 Query: 351 HRSSVNDFDLNPQIPWLVASAEE-ENILQVWKC 382 H V +P + ++A E + +++WK Sbjct: 400 HTDVVISTACHPTENIIASAALENDKTIKLWKS 432 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 95/237 (40%), Gaps = 24/237 (10%) Query: 148 RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLH 207 + L+ TL H ++ FS + L S S D + +W G K +T + H Sbjct: 133 PNYALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDG----KFEKTISG-H 186 Query: 208 SDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLL 267 I+D W + +L + S+D LKI DV + F+ SNL+ Sbjct: 187 KLGISDVAWS-SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLI 244 Query: 268 AAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 + D V ++D++ K L + H D V+ + F+ ++VSS D +WD Sbjct: 245 VSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTAS 302 Query: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 +T D ++ V+ +P +++A A +N L++W S Sbjct: 303 GQCLKTLIDDDNPP-------------VSFVKFSPNGKYILA-ATLDNTLKLWDYSK 345 >6MZM-G nrPDB Length = 800 Score = 170 bits (431), Expect = 7e-43, Method: Composition-based stats. Identities = 57/233 (24%), Positives = 94/233 (40%), Gaps = 12/233 (5%) Query: 113 AKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTL 171 Y H + A + P D N + + + GTV L+S ++ K H + FS Sbjct: 538 ILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP- 595 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 +SG D LW D +P+R + +D +N ++H N + T S D Sbjct: 596 YGYYFVSGGHDRVARLW----ATDHYQPLRIFAGHLAD-VNCTRFHP-NSNYVATGSADR 649 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 +++ DV N P ++L FS + LA D V L+D+ + + Sbjct: 650 TVRLWDVLNGNCVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDI-GHGLMVGEL 707 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 GH D V +L FS + ++ S DN + +WD + + DD + Sbjct: 708 KGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHI 759 Score = 154 bits (388), Expect = 8e-38, Method: Composition-based stats. Identities = 46/228 (20%), Positives = 87/228 (38%), Gaps = 25/228 (10%) Query: 154 STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIIND 213 L H Y SFS + LLS S+D TV LW + + + + H+ + D Sbjct: 537 KILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQT----FTCLVGYKG-HNYPVWD 590 Query: 214 NKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMD 273 ++ F + D + ++ N F +SN +A D Sbjct: 591 TQFSP-YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP-NSNYVATGSAD 648 Query: 274 SYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQT 333 V L+D+ N + +GH+ +++L FS + + +D R+++WD+ Sbjct: 649 RTVRLWDVLNGN-CVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDI-------- 698 Query: 334 PDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 G ++ GH +V + ++AS +N +++W Sbjct: 699 ------GHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWD 739 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 67/183 (36%), Gaps = 19/183 (10%) Query: 206 LHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN 265 HS + + +++ + SED +++ ++ + P FS + Sbjct: 541 GHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY-GY 598 Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 + G D L+ + +PL +GH VN F + + V + +D + +WD+ Sbjct: 599 YFVSGGHDRVARLW-ATDHYQPLRIFAGHLADVNCTRFHPNSN-YVATGSADRTVRLWDV 656 Query: 326 KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 + + GH+ ++ +P +L A+ + + +W H Sbjct: 657 LNGNC--------------VRIFTGHKGPIHSLTFSPNGRFL-ATGATDGRVLLWDIGHG 701 Query: 386 LPI 388 L + Sbjct: 702 LMV 704 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 20/44 (45%), Gaps = 1/44 (2%) Query: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVG 390 + GH V +P +L+ S+ E+ +++W +VG Sbjct: 538 ILYGHSGPVYGASFSPDRNYLL-SSSEDGTVRLWSLQTFTCLVG 580 >6F3T-A nrPDB Length = 608 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 57/236 (24%), Positives = 95/236 (40%), Gaps = 12/236 (5%) Query: 110 RITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSF 168 + Y H + A + P D N + + + GTV L+S ++ K H + F Sbjct: 343 ELKILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQF 401 Query: 169 STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVS 228 S +SG D LW D +P+R + +D +N ++H N + T S Sbjct: 402 SP-YGYYFVSGGHDRVARLW----ATDHYQPLRIFAGHLAD-VNCTRFHP-NSNYVATGS 454 Query: 229 EDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPL 288 D +++ DV N P ++L FS + LA D V L+D+ + Sbjct: 455 ADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDI-GHGLMV 512 Query: 289 HHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 + GH D V +L FS + ++ S DN + +WD + + DD + Sbjct: 513 GELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHI 567 Score = 153 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 59/358 (16%), Positives = 118/358 (32%), Gaps = 65/358 (18%) Query: 61 IGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEE 120 IG+ + ++ N I LP+ + + + + + R Sbjct: 218 IGSKSKKQDPNAPPQNRIPLPE---LKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTF 274 Query: 121 IT-----RARYMPQDPNIVATINGQGTVFLYSRS-------------------------- 149 + A + D +++A TV ++S + Sbjct: 275 LNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLER 334 Query: 150 ------EGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTW 203 L H Y SFS + LLS S+D TV LW + + + + Sbjct: 335 IMDEKTASELKILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQT----FTCLVGY 389 Query: 204 NDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHS 263 H+ + D ++ F + D + ++ N F + Sbjct: 390 KG-HNYPVWDTQFSP-YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP-N 446 Query: 264 SNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 SN +A D V L+D+ N + +GH+ +++L FS + + +D R+++W Sbjct: 447 SNYVATGSADRTVRLWDVLNGN-CVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLW 504 Query: 324 DLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 D+ G ++ GH +V + ++AS +N +++W Sbjct: 505 DI--------------GHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSMDNTVRLWD 547 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 43/122 (35%), Gaps = 21/122 (17%) Query: 287 PLHHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWDL--------KQIGAEQTPDDA 337 + + ++ D +++ G D+ + +W + KQ D Sbjct: 270 CFYTFLNAYQGLTAVDV--TDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKE 327 Query: 338 EDGVPELIM---------VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPI 388 D V E IM + GH V +P +L+ S+ E+ +++W + Sbjct: 328 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLL-SSSEDGTVRLWSLQTFTCL 386 Query: 389 VG 390 VG Sbjct: 387 VG 388 >5FL8-q nrPDB Length = 515 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 115/283 (40%), Gaps = 54/283 (19%) Query: 116 EHEEEITRARYMP-------QDPNIVATINGQGTVFLY-SRSEGLQSTLKFHKDNGYALS 167 H + IT + P P +A+ + GT+ ++ + S Q T+ H ++ + Sbjct: 227 GHSKWITSLSWEPIHLVKPGSKPR-LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVK 285 Query: 168 FSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTV 227 + +G L SGS D TV +W++ S G R N L S W N ++ Sbjct: 286 WGG--QGLLYSGSHDRTVRVWDINSQG------RCINILKSHA----HWVNHL-----SL 328 Query: 228 SEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHH---------SSNLLAAAGMDSYVYL 278 S D L+I A + T P+ A ++ S ++ A D ++L Sbjct: 329 STDYALRI---GAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFL 385 Query: 279 YDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAE 338 ++ +P+ M+GH+ VN++ FS +VS+ DN + +WD Sbjct: 386 WNPLKSTKPIARMTGHQKLVNHVAFSP-DGRYIVSASFDNSIKLWD------------GR 432 Query: 339 DGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 DG + I GH +SV + L+ S ++ L+VW Sbjct: 433 DG--KFISTFRGHVASVYQVAWSSDCR-LLVSCSKDTTLKVWD 472 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 108/304 (35%), Gaps = 52/304 (17%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKG 174 H I + + P + + T G T ++ TLK H + +S+S Sbjct: 141 GHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSP-DGE 199 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFN------KDLFGTVS 228 + +GS D+T+ LW+ SG + + HS I W + K + S Sbjct: 200 VIATGSMDNTIRLWDPKSG----QCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSS 255 Query: 229 EDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPL 288 +D +KI D + + + + LL + D V ++D+ + + Sbjct: 256 KDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWG--GQGLLYSGSHDRTVRVWDINSQGRCI 313 Query: 289 HHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDA---------ED 339 + + H VN+L ST D + D+ K E+ A ++ Sbjct: 314 NILKSHAHWVNHLSLST--DYALRIGAFDHTGK----KPSTPEEAQKKALENYEKICKKN 367 Query: 340 GVPELIMVHA----------------------GHRSSVNDFDLNPQIPWLVASAEEENIL 377 G E +MV A GH+ VN +P ++V SA +N + Sbjct: 368 GNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIV-SASFDNSI 426 Query: 378 QVWK 381 ++W Sbjct: 427 KLWD 430 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 41/264 (15%), Positives = 97/264 (36%), Gaps = 41/264 (15%) Query: 154 STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIIND 213 S + H +F+ R+++G+ D+T +W+ D P+ T H + + Sbjct: 137 SAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDC----DTQTPMHTLKG-HYNWVLC 191 Query: 214 NKWHNFNKDLFGTVSEDSLLKINDVRANNTTID-TVKCPQPFNTLAFS------HHSSNL 266 W + ++ T S D+ +++ D ++ D + +L++ S Sbjct: 192 VSWSP-DGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPR 250 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 LA++ D + ++D + + MSGH ++V+ +++ G++ S D + +WD+ Sbjct: 251 LASSSKDGTIKIWDTV-SRVCQYTMSGHTNSVSCVKW--GGQGLLYSGSHDRTVRVWDIN 307 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL-------------------------N 361 G + + + + + FD N Sbjct: 308 SQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKN 367 Query: 362 PQIPWLVASAEEENILQVWKCSHS 385 ++ +A ++ + +W S Sbjct: 368 GNSEEMMVTASDDYTMFLWNPLKS 391 Score = 120 bits (301), Expect = 8e-28, Method: Composition-based stats. Identities = 31/195 (15%), Positives = 63/195 (32%), Gaps = 23/195 (11%) Query: 195 DPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPF 254 P + H I + + T + D+ +I D Sbjct: 130 KPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWV 189 Query: 255 NTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFS------THVD 308 +++S ++A MD+ + L+D ++ + + GH + +L + Sbjct: 190 LCVSWSP-DGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSK 248 Query: 309 GVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLV 368 + SS D + +WD + T GH +SV+ Q L+ Sbjct: 249 PRLASSSKDGTIKIWDTVSRVCQYTMS--------------GHTNSVSCVKWGGQG--LL 292 Query: 369 ASAEEENILQVWKCS 383 S + ++VW + Sbjct: 293 YSGSHDRTVRVWDIN 307 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 43/249 (17%), Positives = 87/249 (34%), Gaps = 50/249 (20%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG--LQSTLKFHKDNGYALSFST-- 170 H ++ ++ Q ++ + + TV ++ + + LK H LS ST Sbjct: 275 SGHTNSVSCVKWGGQG--LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDY 332 Query: 171 ------------------------------------LVKGRLLSGSDDHTVALWEVGSGG 194 + +++ SDD+T+ LW Sbjct: 333 ALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKST 392 Query: 195 DPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPF 254 P + H ++N + + + + S D+ +K+ D R Sbjct: 393 KPIARM----TGHQKLVNHVAFSPDGRYIV-SASFDNSIKLWDGRDGKFISTFRGHVASV 447 Query: 255 NTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSS 314 +A+S LL + D+ + ++D+R K + + GH+D V +++S V S Sbjct: 448 YQVAWS-SDCRLLVSCSKDTTLKVWDVRTRKLSV-DLPGHKDEVYTVDWS-VDGKRVCSG 504 Query: 315 GSDNRLMMW 323 G D + +W Sbjct: 505 GKDKMVRLW 513 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 56/134 (41%), Gaps = 9/134 (6%) Query: 105 PRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNG 163 +S I H++ + + P D + + + ++ L+ R ST + H + Sbjct: 389 LKSTKPIARMTGHQKLVNHVAFSP-DGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASV 447 Query: 164 YALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDL 223 Y +++S+ + L+S S D T+ +W+V + + + H D + W + Sbjct: 448 YQVAWSSDCR-LLVSCSKDTTLKVWDVRT-----RKLSVDLPGHKDEVYTVDWS-VDGKR 500 Query: 224 FGTVSEDSLLKIND 237 + +D ++++ Sbjct: 501 VCSGGKDKMVRLWT 514 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 25/153 (16%), Positives = 52/153 (33%), Gaps = 25/153 (16%) Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSY----------VYLYDLRNMKEPLH 289 + TI K P T+ + + + L G +S ++ ++ + Sbjct: 78 TFSCTIQGKKASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSSS 137 Query: 290 HMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 ++GH + F+ H +V+ DN +WD T Sbjct: 138 AIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTL--------------K 183 Query: 350 GHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 GH + V +P ++A+ +N +++W Sbjct: 184 GHYNWVLCVSWSPDGE-VIATGSMDNTIRLWDP 215 Score = 35.9 bits (81), Expect = 0.032, Method: Composition-based stats. Identities = 9/40 (22%), Positives = 17/40 (42%) Query: 349 AGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPI 388 AGH S++ P + + +N ++W C P+ Sbjct: 140 AGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPM 179 >2H9P-A nrPDB Length = 329 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 50/294 (17%), Positives = 124/294 (42%), Gaps = 30/294 (10%) Query: 92 EEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLY-SRSE 150 G + + + P ++ T H + ++ ++ P + +A+ + + ++ + Sbjct: 15 YFQGTQSKPTPVKPNYALKFTL-AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDG 72 Query: 151 GLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI 210 + T+ HK +++S+ L+S SDD T+ +W+V SG K ++T HS+ Sbjct: 73 KFEKTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSSG----KCLKTLKG-HSNY 126 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 + ++ +L + S D ++I DV+ P + + F+ +L+ ++ Sbjct: 127 VFCCNFNPQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSS 184 Query: 271 GMDSYVYLYDLRNMKEPLHHMSGHED-AVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG 329 D ++D + L + ++ V+ ++FS + ++ ++ DN L +WD + Sbjct: 185 SYDGLCRIWDT-ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK-- 240 Query: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDF--DLNPQIPWLVASAEEENILQVWK 381 + + + GH++ + + + S E+N++ +W Sbjct: 241 ------------GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 282 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 120/273 (43%), Gaps = 29/273 (10%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVK 173 H+ I+ + D N++ + + T+ ++ S G TLK H + + +F+ Sbjct: 79 SGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QS 136 Query: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 ++SGS D +V +W+V +G K ++T HSD ++ + N + L + S D L Sbjct: 137 NLIVSGSFDESVRIWDVKTG----KCLKTLP-AHSDPVSAVHF-NRDGSLIVSSSYDGLC 190 Query: 234 KINDVRANNTTIDTVKCPQ-PFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 +I D + + P + + FS + +LA A +D+ + L+D + + L + Sbjct: 191 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDY-SKGKCLKTYT 248 Query: 293 GHEDAVNNL--EFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 GH++ + FS +VS DN + +W+L+ E++ G Sbjct: 249 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ--------------TKEIVQKLQG 294 Query: 351 HRSSVNDFDLNPQIPWLVASAEE-ENILQVWKC 382 H V +P + ++A E + +++WK Sbjct: 295 HTDVVISTACHPTENIIASAALENDKTIKLWKS 327 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 95/237 (40%), Gaps = 24/237 (10%) Query: 148 RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLH 207 + L+ TL H ++ FS + L S S D + +W G K +T + H Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDG----KFEKTISG-H 81 Query: 208 SDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLL 267 I+D W + +L + S+D LKI DV + F+ SNL+ Sbjct: 82 KLGISDVAWS-SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-SNLI 139 Query: 268 AAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 + D V ++D++ K L + H D V+ + F+ ++VSS D +WD Sbjct: 140 VSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTAS 197 Query: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 +T D ++ V+ +P +++A A +N L++W S Sbjct: 198 GQCLKTLIDDDNPP-------------VSFVKFSPNGKYILA-ATLDNTLKLWDYSK 240 >3DM0-A nrPDB Length = 694 Score = 168 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 50/276 (18%), Positives = 107/276 (38%), Gaps = 38/276 (13%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG------LQSTLKFHKDNGYALSFST 170 H + +T + +I+ + + ++ L+ ++ Q L H + S+ Sbjct: 381 HTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSS 440 Query: 171 LVKGRL-LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 G+ LSGS D + LW++ +G + V H+ + + N+ + + S Sbjct: 441 --DGQFALSGSWDGELRLWDLAAGVSTRRFV-----GHTKDVLSVAFSLDNRQIV-SASR 492 Query: 230 DSLLKIND-VRANNTTIDT--VKCPQPFNTLAFSHHSSN-LLAAAGMDSYVYLYDLRNMK 285 D +K+ + + TI + + FS ++ + +A D V +++L N K Sbjct: 493 DRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCK 552 Query: 286 EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELI 345 ++GH V+ + S + S G D +++WDL + + + Sbjct: 553 LRS-TLAGHTGYVSTVAVSP-DGSLCASGGKDGVVLLWDLAEGKKLYSLEAN-------- 602 Query: 346 MVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 S ++ +P WL A E+ +++W Sbjct: 603 -------SVIHALCFSPNRYWLCA--ATEHGIKIWD 629 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 98/238 (41%), Gaps = 24/238 (10%) Query: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII 211 L+ T++ H D A++ ++S S D ++ LW++ + HS + Sbjct: 374 LKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFV 433 Query: 212 NDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG 271 D + + + S D L++ D+ A +T V + ++AFS + + +A Sbjct: 434 EDV-VLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFS-LDNRQIVSAS 491 Query: 272 MDSYVYLYDLRNMKEPLHHM----SGHEDAVNNLEFSTHV-DGVVVSSGSDNRLMMWDLK 326 D + L++ + E + + GH D V+ + FS + +VS+ D + +W+L Sbjct: 492 RDRTIKLWN--TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLS 549 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 +L AGH V+ ++P L AS ++ ++ +W + Sbjct: 550 N--------------CKLRSTLAGHTGYVSTVAVSPDGS-LCASGGKDGVVLLWDLAE 592 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 27/184 (14%), Positives = 64/184 (34%), Gaps = 29/184 (15%) Query: 116 EHEEEITRARYMPQDPN-IVATINGQGTVFLYSRSE-GLQSTLKFHKDNGYALSFSTLVK 173 H + ++ R+ P + + + TV +++ S L+STL H ++ S Sbjct: 515 GHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSP-DG 573 Query: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 SG D V LW++ G + ++ + +I+ + N+ + + + Sbjct: 574 SLCASGGKDGVVLLWDLAEGK------KLYSLEANSVIHALCFSP-NRYWLC-AATEHGI 625 Query: 234 KINDVRANNTTIDT-----------------VKCPQPFNTLAFSHH-SSNLLAAAGMDSY 275 KI D+ + + D + + + + L + D Sbjct: 626 KIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGV 685 Query: 276 VYLY 279 + ++ Sbjct: 686 IRVW 689 >1VYH-C nrPDB Length = 410 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 50/289 (17%), Positives = 100/289 (34%), Gaps = 45/289 (15%) Query: 113 AKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTLKFHKDNGYALSFSTL 171 A H +TR + P ++ + + T+ ++ + + TLK H D+ +SF Sbjct: 103 ALSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD-H 160 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 L S S D T+ LW+ + +RT + H ++ N D + S D Sbjct: 161 SGKLLASCSADMTIKLWDFQG----FECIRTMHG-HDHNVSSVSIMP-NGDHIVSASRDK 214 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 +K+ +V+ + + + L+A+ D V ++ + KE + Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPN-QDGTLIASCSNDQTVRVW-VVATKECKAEL 272 Query: 292 SGHEDAVNNLEFSTHV-------------------DGVVVSSGSDNRLMMWDLKQIGAEQ 332 H V + ++ ++S D + MWD+ Sbjct: 273 REHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVS------ 326 Query: 333 TPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 +M GH + V + +++ S ++ L+VW Sbjct: 327 --------TGMCLMTLVGHDNWVRGVLFHSGGKFIL-SCADDKTLRVWD 366 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 48/287 (16%), Positives = 104/287 (36%), Gaps = 45/287 (15%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRS-EGLQSTLKFHKDNGYALSFSTLVKG 174 H + + + ++A+ + T+ L+ T+ H N ++S Sbjct: 148 GHTDSVQDISFD-HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPN-GD 205 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 ++S S D T+ +WEV +G V+T+ H + + + N + L + S D ++ Sbjct: 206 HIVSASRDKTIKMWEVQTGY----CVKTFTG-HREWVRMVRP-NQDGTLIASCSNDQTVR 259 Query: 235 INDVRANNTTIDTVKCPQPFNTLAFSHHSSN-------------------LLAAAGMDSY 275 + V + + ++++ SS L + D Sbjct: 260 VWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKT 319 Query: 276 VYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD 335 + ++D+ + L + GH++ V + F + ++S D L +WD K Sbjct: 320 IKMWDV-STGMCLMTLVGHDNWVRGVLFHS-GGKFILSCADDKTLRVWDYKNK------- 370 Query: 336 DAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 + H V D + P++V + + ++VW+C Sbjct: 371 -------RCMKTLNAHEHFVTSLDFHKTAPYVV-TGSVDQTVKVWEC 409 Score = 141 bits (354), Expect = 7e-34, Method: Composition-based stats. Identities = 41/237 (17%), Positives = 84/237 (35%), Gaps = 32/237 (13%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFS 169 I + H+ ++ MP + + + + + T+ ++ G T H++ + Sbjct: 185 IRTMHGHDHNVSSVSIMP-NGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV--R 241 Query: 170 TLVKGRL-LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKD------ 222 G L S S+D TV +W V + K + H ++ W + Sbjct: 242 PNQDGTLIASCSNDQTVRVWVVAT-----KECKAELREHRHVVECISWAPESSYSSISEA 296 Query: 223 -------------LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 + S D +K+ DV + V + F H + + Sbjct: 297 TGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLF-HSGGKFILS 355 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 D + ++D +N K + ++ HE V +L+F VV+ D + +W+ + Sbjct: 356 CADDKTLRVWDYKN-KRCMKTLNAHEHFVTSLDFHKTA-PYVVTGSVDQTVKVWECR 410 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 14/87 (16%), Positives = 33/87 (37%), Gaps = 3/87 (3%) Query: 105 PRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTLKFHKDNG 163 + + + H+ + + + + T+ ++ ++ TL H+ Sbjct: 325 VSTGMCLMTLVGHDNWVRGVLFH-SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 383 Query: 164 YALSFSTLVKGRLLSGSDDHTVALWEV 190 +L F +++GS D TV +WE Sbjct: 384 TSLDFHKTAP-YVVTGSVDQTVKVWEC 409 Score = 33.6 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 19/40 (47%), Gaps = 1/40 (2%) Query: 342 PELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 P +GHRS V +P ++ SA E+ ++VW Sbjct: 98 PPEKYALSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWD 136 >5Y88-O nrPDB Length = 451 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 58/239 (24%), Positives = 107/239 (44%), Gaps = 25/239 (10%) Query: 146 YSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWND 205 + L + H ++ + ++GS+D T+ +W++ +G ++T Sbjct: 125 WHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATG-----KLKTTLA 179 Query: 206 LHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN 265 H + D + + LF +VSED +K D+ N D T++ + Sbjct: 180 GHVMTVRDVAVSDRHPYLF-SVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTL-D 237 Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 L+A AG DS + L+D+R + P+ + GH+ +N ++ T VD VVSS +D + +WD+ Sbjct: 238 LIATAGRDSVIKLWDMRT-RIPVITLVGHKGPINQVQ-CTPVDPQVVSSSTDATVRLWDV 295 Query: 326 KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 G ++ H H+ SV L+P+ + VASA ++I + W + Sbjct: 296 VA------------GKTMKVLTH--HKRSVRATALHPKE-FSVASACTDDI-RSWGLAE 338 Score = 120 bits (301), Expect = 9e-28, Method: Composition-based stats. Identities = 46/267 (17%), Positives = 98/267 (36%), Gaps = 27/267 (10%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKG 174 H + P D T + T+ ++ + G L++TL H ++ S Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHP- 195 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 L S S+D TV W++ + + + I+ DL T DS++K Sbjct: 196 YLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIH------PTLDLIATAGRDSVIK 249 Query: 235 INDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH 294 + D+R I V P N + + + ++ D+ V L+D+ + + ++ H Sbjct: 250 LWDMRTRIPVITLVGHKGPINQVQCTPVDPQ-VVSSSTDATVRLWDVV-AGKTMKVLTHH 307 Query: 295 EDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSS 354 + +V + V S+ +D+ + W L + + + G+ Sbjct: 308 KRSVRATALHPK-EFSVASACTDD-IRSWGLAEGSLLTNFESEKTGI------------- 352 Query: 355 VNDFDLNPQIPWLVASAEEENILQVWK 381 +N +N ++ + + +L + Sbjct: 353 INTLSINQDD--VLFAGGDNGVLSFYD 377 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 25/141 (17%), Positives = 56/141 (39%), Gaps = 17/141 (12%) Query: 249 KCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVD 308 +A + D+ + ++DL K ++GH V ++ S Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKT-TLAGHVMTVRDVAVSDRH- 194 Query: 309 GVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLV 368 + S D + WDL++ ++I + GH S V ++P + L+ Sbjct: 195 PYLFSVSEDKTVKCWDLEKN--------------QIIRDYYGHLSGVRTVSIHPTLD-LI 239 Query: 369 ASAEEENILQVWKCSHSLPIV 389 A+A ++++++W +P++ Sbjct: 240 ATAGRDSVIKLWDMRTRIPVI 260 Score = 64.0 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 29/183 (15%), Positives = 63/183 (34%), Gaps = 19/183 (10%) Query: 106 RSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGY 164 R+ I + H+ I + + P DP +V + + TV L+ G L HK + Sbjct: 254 RTRIPVITLVGHKGPINQVQCTPVDPQVV-SSSTDATVRLWDVVAGKTMKVLTHHKRSVR 312 Query: 165 ALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLF 224 A + + +DD + W + G + + + IIN + D+ Sbjct: 313 ATALHPKEFSVASACTDD--IRSWGLAEGS----LLTNFESEKTGIINTLSINQ--DDVL 364 Query: 225 GTVSEDSLLKINDVRAN--------NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYV 276 ++ +L D ++ + +++ + F + L D + Sbjct: 365 FAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFD-KTGLRLITGEADKSI 423 Query: 277 YLY 279 ++ Sbjct: 424 KIW 426 >5WLC-LJ nrPDB Length = 513 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 61/308 (19%), Positives = 113/308 (36%), Gaps = 35/308 (11%) Query: 90 PQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRS 149 PQ+ E+ ++ EH +T + PQ P+ A + SR+ Sbjct: 17 PQQTTPEQRYWRQYTSAQLVK-----EHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRT 70 Query: 150 EGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSD 209 + T KD Y+ SF + G+LL D L V +P + + N + Sbjct: 71 RQVIKTFSRFKDVVYSASFRS--DGKLLCAGD--ATGLVSVYDSYNPRTILLSIN-ASTH 125 Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDV-RANNTTIDTVKCPQPFNTLAFSHHSSNLLA 268 + K+H + + T S+D + ++ D+ A ++ TL+F + +L+A Sbjct: 126 PTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVA 185 Query: 269 AAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 D + LYD R+ + H+ V N+ + +VS G +N +WDL Sbjct: 186 TGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQ--IVSCGGNN-FKVWDL--- 239 Query: 329 GAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL-----NPQIPWLVASAEEENILQVWKCS 383 + + +V D +P L+AS + ++V+ Sbjct: 240 -----------TSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIAS-SLDGHVKVFDPL 287 Query: 384 HSLPIVGG 391 + + G Sbjct: 288 DNFQVKFG 295 >4A11-B nrPDB Length = 408 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 45/239 (18%), Positives = 90/239 (37%), Gaps = 15/239 (6%) Query: 157 KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTK--------PVRTWNDLHS 208 + H L + +LSG D + L+++ + + R D+H Sbjct: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 Query: 209 DIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSS--NL 266 + +W+ + +F + S D LK+ D T D + + S S+ L Sbjct: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-TADVFNFEETVYSHHMSPVSTKHCL 158 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 +A V L DL+ H + GH + + +S D ++ ++ +D+R+ +WD++ Sbjct: 159 VAVGTRGPKVQLCDLK-SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 Query: 327 QIGAEQTPDDAEDGVPELI--MVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 + D +G + H VN L+ + +N +++W S Sbjct: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRLWNSS 275 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 42/280 (15%), Positives = 91/280 (32%), Gaps = 34/280 (12%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRS----------EGLQSTLKFHKD----N 162 H I P + + + G + LY + + S + H D + Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 163 GYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKD 222 + + G S S D T+ +W+ + + +N + + + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNT----LQTADVFNFEETVYSHHMSPVSTKHC 157 Query: 223 LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLR 282 L + +++ D+++ + + Q +++S +LA A DS V L+D+R Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 Query: 283 NMKEPLHHM---------------SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 L + + H VN L F++ ++ G+DNR+ +W+ Sbjct: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTV-GTDNRMRLWNSSN 276 Query: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWL 367 + + ++F P + Sbjct: 277 GENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTI 316 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 49/290 (16%), Positives = 94/290 (32%), Gaps = 36/290 (12%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGR- 175 H + ++ P D + + + T+ ++ + + + ++ Y+ S + Sbjct: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 Query: 176 -LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 + G+ V L ++ SG H I W + T S DS +K Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCS-----HILQGHRQEILAVSWSPRYDYILATASADSRVK 212 Query: 235 INDVRANNTTIDTV----------------KCPQPFNTLAFSHHSSNLLAAAGMDSYVYL 278 + DVR + + T+ N L F+ +LL G D+ + L Sbjct: 213 LWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLL-TVGTDNRMRL 271 Query: 279 YDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAE 338 ++ N + + + + NN S VS G + + + T Sbjct: 272 WNSSNGE---NTLVNYGKVCNN---SKKGLKFTVSCGCSSEFVF-----VPYGSTIAVYT 320 Query: 339 DGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPI 388 E I + GH +V+ L S + + W S P+ Sbjct: 321 VYSGEQITMLKGHYKTVDCCVFQSNFQELY-SGSRDCNILAWVPSLYEPV 369 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 34/199 (17%), Positives = 65/199 (32%), Gaps = 46/199 (23%) Query: 230 DSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH 289 +S ++ + N NTL + + G D + LYDL N + Sbjct: 22 ESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSY 81 Query: 290 HM--------SGHED----AVNNLEFSTHVDGVVVSSGSDNRLMMWD------------- 324 + H D +V +++ H G+ SS D L +WD Sbjct: 82 YTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFE 141 Query: 325 -------------------LKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIP 365 + G + D + G I+ GHR + +P+ Sbjct: 142 ETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHIL--QGHRQEILAVSWSPRYD 199 Query: 366 WLVASAEEENILQVWKCSH 384 +++A+A ++ +++W Sbjct: 200 YILATASADSRVKLWDVRR 218 >3JB9-L nrPDB Length = 340 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 116/302 (38%), Gaps = 49/302 (16%) Query: 113 AKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQ--STLKFHKDNGYALSFST 170 + H E+ AR+ P + A+ + L++ ++ L K L +S Sbjct: 45 QMFGHTAEVLVARFDPS-GSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSR 103 Query: 171 LVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED 230 + S SD H ++ W+ SG K + H+ ++N +L +VS+D Sbjct: 104 DSRVVYCSSSDTHLMS-WDAVSGQKIRK-----HKGHAGVVNALDVLKVGSELLTSVSDD 157 Query: 231 SLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHH 290 +K+ D R+ + I T++ P +A + + + G+D + ++DLRN H Sbjct: 158 CTMKVWDSRSKDC-IKTIEEKYPLTAVAIAQQGTQVFI-GGIDGAIKIWDLRN-NHCSHV 214 Query: 291 MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDG---------- 340 + GH+D + +L S ++S+ DN + ++D+K + Q +G Sbjct: 215 LKGHKDIITSLAISK-DGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLL 273 Query: 341 -------------------------VPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEEN 375 +L V GH SVN D +P ++ S + Sbjct: 274 GVAWSRNSRFVGAGSSDKNVYVWSATGDLRYVLPGHEGSVNHVDFHPHQD-IILSCSSDR 332 Query: 376 IL 377 + Sbjct: 333 TI 334 Score = 95.3 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 45/233 (19%), Positives = 92/233 (39%), Gaps = 29/233 (12%) Query: 107 SNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLY-SRSEGLQSTLKFHKDNGYA 165 S +I H + + ++ +++ T+ ++ SRS+ T++ K A Sbjct: 124 SGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIE-EKYPLTA 182 Query: 166 LSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFG 225 ++ ++ G D + +W++ + H DII L Sbjct: 183 VAI-AQQGTQVFIGGIDGAIKIWDLRNNHCS-----HVLKGHKDIITSLAISKDGSSLL- 235 Query: 226 TVSEDSLLKINDVRANNTT--------IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVY 277 + S D+ ++I DV+ + +A+S +S + A D VY Sbjct: 236 SNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWS-RNSRFVGAGSSDKNVY 294 Query: 278 LY----DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 ++ DLR + + GHE +VN+++F H D +++S SD + + +L Sbjct: 295 VWSATGDLR------YVLPGHEGSVNHVDFHPHQD-IILSCSSDRTIFLGELN 340 >6N9G-C nrPDB Length = 353 Score = 158 bits (398), Expect = 6e-39, Method: Composition-based stats. Identities = 47/210 (22%), Positives = 86/210 (40%), Gaps = 12/210 (5%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLV-KG 174 H ++ + D I+ T +G GT L+ G L + H + L + Sbjct: 152 HTNYLSACSFTNSDMQIL-TASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGN 210 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 +SG D +W++ SG + V+ + SD +N +++ + D F + S+D+ + Sbjct: 211 TFVSGGCDKKAMVWDMRSG----QCVQAFETHESD-VNSVRYYP-SGDAFASGSDDATCR 264 Query: 235 INDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM-DSYVYLYDLRNMKEPLHHMSG 293 + D+RA+ K F + S L AG D + ++D+ + + G Sbjct: 265 LYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLK-GSRVSILFG 323 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 HE+ V+ L S S D+ L +W Sbjct: 324 HENRVSTLRVSPDGTAFC-SGSWDHTLRVW 352 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 105/271 (38%), Gaps = 35/271 (12%) Query: 120 EITRARYMPQDPNIVATINGQGTVFLYSRSEGLQ-------STLKFHKDNGYALSFSTLV 172 + Y P +A +Y + ++ H + A SF T Sbjct: 107 WVMACAYAPS-GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF-TNS 164 Query: 173 KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSL 232 ++L+ S D T ALW+V SG + +++++ +D++ + + + F + D Sbjct: 165 DMQILTASGDGTCALWDVESG----QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKK 220 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 + D+R+ N++ + S + A+ D+ LYDLR +E + Sbjct: 221 AMVWDMRSGQCVQAFETHESDVNSVRYYP-SGDAFASGSDDATCRLYDLRADREVAIYSK 279 Query: 293 GHEDAV---NNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 E + ++++FS ++ + +D + +WD+ + + + Sbjct: 280 --ESIIFGASSVDFS-LSGRLLFAGYNDYTINVWDVLK--------------GSRVSILF 322 Query: 350 GHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 GH + V+ ++P S ++ L+VW Sbjct: 323 GHENRVSTLRVSPDGT-AFCSGSWDHTLRVW 352 Score = 94.9 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 42/237 (17%), Positives = 77/237 (32%), Gaps = 35/237 (14%) Query: 154 STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPV--RTWNDLHSDII 211 TLK H + + + K R++S S D V +W+ + TW + Sbjct: 57 RTLKGHGNKVLCMDW-CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTW-------V 108 Query: 212 NDNKWHNFNKDLFGTVSEDSLLKI----NDVRANNTTIDTV--KCPQPFNTLAFSHHSSN 265 + + D+ + D N + +F++ Sbjct: 109 MACAYAPSGCAIAC-GGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 167 Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWD 324 +L A D L+D+ + + L GH V L+ + G VS G D + M+WD Sbjct: 168 IL-TASGDGTCALWDVESGQL-LQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWD 225 Query: 325 LKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 ++ + + H S VN P AS ++ +++ Sbjct: 226 MR--------------SGQCVQAFETHESDVNSVRYYPSGD-AFASGSDDATCRLYD 267 >4V8M-A7 nrPDB Length = 318 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 49/238 (20%), Positives = 103/238 (43%), Gaps = 28/238 (11%) Query: 156 LKFHKDNGYALSF--STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWND----LHSD 209 L H+ +L+ + +++S S D T+ W ++ D HS Sbjct: 9 LTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSA 68 Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 ++D N N + + S D L++ +++ + + ++AFS + ++ + Sbjct: 69 FVSDVALSN-NGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIV-S 126 Query: 270 AGMDSYVYLYDLRNMKEPLHHMS--GHEDAVNNLEFSTHVD-GVVVSSGSDNRLMMWDLK 326 G D+ + +++++ E +H +S H D V+ + FS +D V+VS G DN + +WDL Sbjct: 127 GGRDNALRVWNVK--GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDL- 183 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 L+ GH + V ++P L AS++++ + ++W + Sbjct: 184 -------------ATGRLVTDLKGHTNYVTSVTVSPDGS-LCASSDKDGVARLWDLTK 227 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 47/299 (15%), Positives = 110/299 (36%), Gaps = 27/299 (9%) Query: 89 DPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS- 147 P + S P + H ++ + N + + ++ L++ Sbjct: 44 GPNPDRHSSECS-YGLPDRRLE-----GHSAFVSDVALSN-NGNFAVSASWDHSLRLWNL 96 Query: 148 RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLH 207 ++ Q H + +++FS +++SG D+ + +W V G R H Sbjct: 97 QNGQCQYKFLGHTKDVLSVAFSP-DNRQIVSGGRDNALRVWNVK-GECMHTLSR---GAH 151 Query: 208 SDIINDNKWHNF-NKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL 266 +D ++ ++ + + + D+L+K+ D+ D ++ S +L Sbjct: 152 TDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSP-DGSL 210 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 A++ D L+DL E L M+ +N + FS + + + ++ + ++DL+ Sbjct: 211 CASSDKDGVARLWDL-TKGEALSEMAAGA-PINQICFSPN--RYWMCAATEKGIRIFDLE 266 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 G +++ V+ + L S +N+++VW S + Sbjct: 267 NKDIIVELAPEHQGSKKIV------PECVS-IAWSADGSTLY-SGYTDNVIRVWGVSEN 317 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 36/224 (16%), Positives = 85/224 (37%), Gaps = 20/224 (8%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKF--HKDNGYALSFSTLV 172 H +++ + P + IV + + +++ TL H D + FS + Sbjct: 106 LGHTKDVLSVAFSPDNRQIV-SGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSL 164 Query: 173 KG-RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 ++SG D+ V +W++ +G + V H++ + + L + +D Sbjct: 165 DAPVIVSGGWDNLVKVWDLATG----RLVTDLKG-HTNYVTSVTVSP-DGSLCASSDKDG 218 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 + ++ D+ + + P N + FS + + AA + ++DL N + Sbjct: 219 VARLWDL-TKGEALSEMAAGAPINQICFSP-NRYWMCAATE-KGIRIFDLENKDIIVELA 275 Query: 292 SGHED------AVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG 329 H+ ++ +S + S +DN + +W + + Sbjct: 276 PEHQGSKKIVPECVSIAWS-ADGSTLYSGYTDNVIRVWGVSENA 318 >2PM9-A nrPDB Length = 416 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 121/296 (40%), Gaps = 44/296 (14%) Query: 105 PRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG---LQSTLKF--H 159 P +++++ +K+ + + I+A G++ LYS +E + S +F H Sbjct: 60 PIASLQVDSKFNDLDW-------SHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNH 112 Query: 160 KDNGYALSFSTLVKGRLLSGSDDHTVALWEVG------SGGDPTKPVRTWNDLHSDIIND 213 + + F+ L SG ++ + +W++ S P P ++ + + D + Sbjct: 113 SSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSV--DEVIS 170 Query: 214 NKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTV------KCPQPFNTLAFSHHSSNLL 267 W+ +F + + I D++A I Q + + + +S + Sbjct: 171 LAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRV 230 Query: 268 AAAGM---DSYVYLYDLRNMKEPLHHM-SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 A A D + ++DLRN PL + GH+ + +L++ + +++SSG DN +++W Sbjct: 231 ATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLW 290 Query: 324 DLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 + P+ AE + + P+ P L A A +N ++V Sbjct: 291 N---------PESAEQ-----LSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEV 332 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 40/250 (16%), Positives = 94/250 (37%), Gaps = 17/250 (6%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQS------TLKFHK----DNGY 164 H + ++ + N++A+ G +F++ ++ +S D Sbjct: 110 SNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVI 169 Query: 165 ALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTW-NDLHSDIINDNKWHNFNKDL 223 +L+++ + S + ++W++ + + T N ++ +WH N Sbjct: 170 SLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTR 229 Query: 224 F--GTVSE-DSLLKINDVRANNTTIDTV--KCPQPFNTLAFSHHSSNLLAAAGMDSYVYL 278 T S+ D + I D+R NT + T+ + +L + H +LL ++G D+ V L Sbjct: 230 VATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLL 289 Query: 279 YDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAE 338 ++ + E L + +F+ + + DN++ + L+ + + E Sbjct: 290 WNPESA-EQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETE 348 Query: 339 DGVPELIMVH 348 E Sbjct: 349 TKQQESETDF 358 Score = 92.9 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 48/284 (16%), Positives = 118/284 (41%), Gaps = 38/284 (13%) Query: 135 ATINGQGTVFLYSR----SEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS-DDHTVALWE 189 A + ++ L+S SE ++L+ L +S ++++G+ D+ ++ L+ Sbjct: 39 ANFSTDSSLELWSLLAADSEKPIASLQVDSKF-NDLDWSHN--NKIIAGALDNGSLELYS 95 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTT----- 244 + + +++ HS + K++ ++ + + + I D+ + Sbjct: 96 TNEANNAINSMARFSN-HSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYT 154 Query: 245 ----IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM-----SGHE 295 ++ +LA++ +++ A+AG ++ ++DL+ KE +H SG + Sbjct: 155 PLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIK 214 Query: 296 DAVNNLEFSTHVDGVVVSS-GSDN--RLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHR 352 ++ +E+ V ++ GSDN +++WDL+ L ++ GH+ Sbjct: 215 QQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANT------------PLQTLNQGHQ 262 Query: 353 SSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVN 396 + D Q L+ S+ +N + +W + + P + N Sbjct: 263 KGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGN 306 >3FM0-A nrPDB Length = 345 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 114/286 (39%), Gaps = 32/286 (11%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG---LQSTLKFHKDNGYALSFSTLV 172 H+ + + + P N +A+ + T ++ +++ +TL+ H++ +++++ Sbjct: 59 GHQRTVRKVAWSPC-GNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS- 116 Query: 173 KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSL 232 L + S D +V +WEV D + V N H+ + WH +++L + S D Sbjct: 117 GNLLATCSRDKSVWVWEV-DEEDEYECVSVLNS-HTQDVKHVVWHP-SQELLASASYDDT 173 Query: 233 LKINDVRANN--TTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD--LRN----- 283 +K+ ++ +LAF S LA+ D V ++ L Sbjct: 174 VKLYREEEDDWVCCATLEGHESTVWSLAFDP-SGQRLASCSDDRTVRIWRQYLPGNEQGV 232 Query: 284 -------MKEPLHHMSG-HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD 335 + + +SG H + ++ + + G + ++ D+ + ++ Q P Sbjct: 233 ACSGSDPSWKCICTLSGFHSRTIYDIAWC-QLTGALATACGDDAIRVFQEDPNSDPQQPT 291 Query: 336 DAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 + +H H VN NP+ P L+AS ++ + WK Sbjct: 292 FSLTAH-----LHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 38/221 (17%), Positives = 81/221 (36%), Gaps = 23/221 (10%) Query: 164 YALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDL 223 + L+++ L S D + +W G+ GD ++ H + W L Sbjct: 20 WFLAWNPA-GTLLASCGGDRRIRIW--GTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYL 76 Query: 224 FGTVSEDSLLKIN--DVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY-- 279 + S D+ I + ++A++ S NLLA D V+++ Sbjct: 77 -ASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAP-SGNLLATCSRDKSVWVWEV 134 Query: 280 DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAED 339 D + E + ++ H V ++ + + ++ S+ D+ + ++ E+ Sbjct: 135 DEEDEYECVSVLNSHTQDVKHVVWHPSQE-LLASASYDDTVKLY------------REEE 181 Query: 340 GVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 GH S+V +P L AS ++ +++W Sbjct: 182 DDWVCCATLEGHESTVWSLAFDPSGQRL-ASCSDDRTVRIW 221 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 40/246 (16%), Positives = 79/246 (32%), Gaps = 37/246 (15%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG----LQSTLKFHKDNGYAL 166 +T HE E+ + P N++AT + +V+++ E S L H + + Sbjct: 98 VTTLEGHENEVKSVAWAPS-GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHV 156 Query: 167 SFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGT 226 + + L S S D TV L+ D T H + + + + + Sbjct: 157 VWHPSQE-LLASASYDDTVKLY--REEEDDWVCCATLEG-HESTVWSLAF-DPSGQRLAS 211 Query: 227 VSEDSLLKIN----------------DVRANNTTIDTVK-CPQPFNTLAFSHHSSNLLAA 269 S+D ++I D + + +A+ + LA Sbjct: 212 CSDDRTVRIWRQYLPGNEQGVACSGSDP-SWKCICTLSGFHSRTIYDIAWC-QLTGALAT 269 Query: 270 AGMDSYVYLYDL--------RNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLM 321 A D + ++ H H VN + ++ G++ S D + Sbjct: 270 ACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVA 329 Query: 322 MWDLKQ 327 W ++ Sbjct: 330 FWKYQR 335 >5OPT-p nrPDB Length = 318 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 104/238 (43%), Gaps = 28/238 (11%) Query: 156 LKFHKDNGYALSFSTLVKGRL--LSGSDDHTVALWEVGSGGDPTKPVRTWND----LHSD 209 LK H+ AL+ + + + +S S D+T+ W + + + + HS Sbjct: 9 LKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSA 68 Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 ++D N N D + S D L++ +++ + + ++ FS + ++ + Sbjct: 69 FVSDVALSN-NGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIV-S 126 Query: 270 AGMDSYVYLYDLRNMKEPLHHM--SGHEDAVNNLEFSTHVD-GVVVSSGSDNRLMMWDLK 326 G D+ + +++++ E LH + H D V+ + FS ++ ++VS G DN + +WD+ Sbjct: 127 GGRDNALRVWNVK--GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDI- 183 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 L+ GH + + ++P L AS++++ + ++W + Sbjct: 184 -------------ASGRLLTDLKGHTNYITSVTVSPDGS-LCASSDKDGVARLWDLTK 227 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 47/276 (17%), Positives = 107/276 (38%), Gaps = 31/276 (11%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKG 174 H ++ + + + + ++ L++ G Q H + +++FS Sbjct: 65 GHSAFVSDVALSN-NGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSP-DNR 122 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTW-NDLHSDIINDNKWHNF-NKDLFGTVSEDSL 232 +++SG D+ + +W V + + T H+D ++ ++ L + D+L Sbjct: 123 QIVSGGRDNALRVWNVKG-----ECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNL 177 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 +K+ D+ + D ++ S +L A++ D L+DL E L M+ Sbjct: 178 VKVWDIASGRLLTDLKGHTNYITSVTVSP-DGSLCASSDKDGVARLWDL-TKGEALSEMA 235 Query: 293 GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL--KQIGAEQTPDDAEDG--VPELIMVH 348 +N + FS + + + ++ + ++DL K + E P+ + PE + + Sbjct: 236 AGA-PINQICFSPN--RYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSI- 291 Query: 349 AGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 + L S +N+++VW S Sbjct: 292 ----------AWSADGNTLY-SGYTDNVIRVWSVSE 316 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 39/223 (17%), Positives = 88/223 (39%), Gaps = 22/223 (9%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKF--HKDNGYALSFSTLV 172 H +++ + P + IV + + +++ TL H D + FS + Sbjct: 106 LGHTKDVLSVTFSPDNRQIV-SGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSL 164 Query: 173 KGRL-LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 + L +SG D+ V +W++ SG + T H++ I + L + +D Sbjct: 165 ETPLIVSGGWDNLVKVWDIASG-----RLLTDLKGHTNYITSVTVSP-DGSLCASSDKDG 218 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 + ++ D+ + + P N + FS + + AA + ++DL N K+ + + Sbjct: 219 VARLWDL-TKGEALSEMAAGAPINQICFSP-NRYWMCAATE-KGIRIFDLEN-KDVIVEL 274 Query: 292 SGHED-------AVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 + ++ +S + S +DN + +W + + Sbjct: 275 APEAQQKSKKTPECMSIAWS-ADGNTLYSGYTDNVIRVWSVSE 316 >5OQL-d nrPDB Length = 446 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 69/355 (19%), Positives = 127/355 (35%), Gaps = 70/355 (19%) Query: 81 PKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKY------EHEEEITRARYMPQDPNIV 134 P+ + P E EYQ +L A + + H + + N + Sbjct: 24 PRNLAPELHP-FERAREYQRALNAVKLERMFAKPFLGQLGNGHVQGVYSMCKDKNSLNCI 82 Query: 135 ATINGQGTVFLYSRSEGLQSTLK--FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGS 192 A+ +G G V ++ + + T + H + L+F +LLS + D + LW+ + Sbjct: 83 ASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTF--TNDKKLLSCATDG-IKLWDPYA 139 Query: 193 GGDPTKPV------------------------------RTWNDLHS------------DI 210 T P+ R W+ HS D Sbjct: 140 SPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDT 199 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 I D ++ + G+V+ D + + D+R N I TV N + F+ + LA A Sbjct: 200 ITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLH-FACNRIVFNPMEAMNLAVA 258 Query: 271 GMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGA 330 D +Y++D RN + L+ GH AV ++EFS + +VS D + +W Sbjct: 259 SEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEE-LVSGSYDRTIRLW------- 310 Query: 331 EQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 D + H V +++ + ++ +++W+ + S Sbjct: 311 ------RRDAGHSRDVYHTKRMQRVFRTMWTMDSKYIL-TGSDDGNVRLWRANAS 358 Score = 67.1 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 56/143 (39%), Gaps = 12/143 (8%) Query: 122 TRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTL---KFHKDNGYALSFSTLVKGRLLS 178 R + P + +A + ++++ + L K H + FS + L+S Sbjct: 243 NRIVFNPMEAMNLAVASEDHNIYIFD-ARNFDKALNIQKGHVAAVMDVEFSPTGE-ELVS 300 Query: 179 GSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDV 238 GS D T+ LW +G ++ V + + W + T S+D +++ Sbjct: 301 GSYDRTIRLWRRDAG--HSRDVYHTKRMQR--VFRTMW-TMDSKYILTGSDDGNVRLW-- 353 Query: 239 RANNTTIDTVKCPQPFNTLAFSH 261 RAN + VK + L +++ Sbjct: 354 RANASERSGVKATRQRQALEYNN 376 Score = 49.0 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 32/87 (36%), Gaps = 6/87 (6%) Query: 113 AKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDN---GYALSFS 169 + H + + P + + + T+ L+ R G + +H + + Sbjct: 278 IQKGHVAAVMDVEFSPT-GEELVSGSYDRTIRLWRRDAGHSRDV-YHTKRMQRVFRTMW- 334 Query: 170 TLVKGRLLSGSDDHTVALWEVGSGGDP 196 T+ +L+GSDD V LW + Sbjct: 335 TMDSKYILTGSDDGNVRLWRANASERS 361 >5OQL-L nrPDB Length = 557 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 46/201 (22%), Positives = 83/201 (41%), Gaps = 15/201 (7%) Query: 130 DPNIVATINGQGTVFLYSRSEG----LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTV 185 D ++ G + ++ +G + T HK + +S L+S SDD TV Sbjct: 110 DGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTV 169 Query: 186 ALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN--FNKDLFGTVSEDSLLKINDVRANNT 243 LW++ S H+D + + N +L + S D +++ D RA Sbjct: 170 RLWDLPSNDPTR-----LFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGG 224 Query: 244 TIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEF 303 + T K P + + LLAA+G + + + DL K PL ++ H+ V +L Sbjct: 225 AVMTFKHADPIEDVLPLPSGTTLLAASG--NAISVLDLVAAK-PLRLITNHQKTVTSLSL 281 Query: 304 STHVDGVVVSSGSDNRLMMWD 324 ++ VVS D + +++ Sbjct: 282 ASQG-RRVVSGSLDGHVKVFE 301 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 32/198 (16%), Positives = 64/198 (32%), Gaps = 34/198 (17%) Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVK---CPQPFNTLAFSHHSSNLLAAAGMDS 274 + + + +++ DV + QP +S L + D Sbjct: 108 RPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDK 167 Query: 275 YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTH--VDGVVVSSGSDNRLMMWDLKQIGAEQ 332 V L+DL +P +GH D V F ++VS D + +WD + G Sbjct: 168 TVRLWDLP-SNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAV 226 Query: 333 TPDDAEDGVPELIMVHAG---------------------------HRSSVNDFDLNPQIP 365 D + +++ + +G H+ +V L Q Sbjct: 227 MTFKHADPIEDVLPLPSGTTLLAASGNAISVLDLVAAKPLRLITNHQKTVTSLSLASQGR 286 Query: 366 WLVASAEEENILQVWKCS 383 +V S + ++V++ + Sbjct: 287 RVV-SGSLDGHVKVFETT 303 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 30/167 (17%), Positives = 63/167 (37%), Gaps = 11/167 (6%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSF--STLVK 173 H++ + ++ P + + + + TV L+ S H D +F + Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANS 202 Query: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 L+SGS D TV +W+ + P V T+ H+D I D L + + Sbjct: 203 NLLVSGSYDETVRVWDARA---PGGAVMTFK--HADPIEDVLPLPSGTTLLAASG--NAI 255 Query: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD 280 + D+ A + +L+ + + + +D +V +++ Sbjct: 256 SVLDLVAAKPLRLITNHQKTVTSLSLA-SQGRRVVSGSLDGHVKVFE 301 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 27/210 (12%), Positives = 57/210 (27%), Gaps = 30/210 (14%) Query: 186 ALWEVGSGGDPTKPVRTWNDLH---------SDIINDNKWHN-FNKDLFGTVSEDSLLKI 235 W W H + +++ + DLF + ++I Sbjct: 25 RYWRSFKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPR-VEI 83 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH- 294 +R + + +L A + ++D+ + + H Sbjct: 84 FSIRKREPLKTIGRFDSEAHCGEIRP-DGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHI 142 Query: 295 -EDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 + V ++S ++S D + +WDL + GH Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDP--------------TRLFTGHTD 188 Query: 354 SVNDFDLNP--QIPWLVASAEEENILQVWK 381 V P L+ S + ++VW Sbjct: 189 YVRCGAFMPGSANSNLLVSGSYDETVRVWD 218 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 23/147 (15%), Positives = 50/147 (34%), Gaps = 25/147 (17%) Query: 247 TVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM-----SGHEDAVNNL 301 ++ ++ + +N L A V ++ +R +EPL + H + Sbjct: 52 SLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRK-REPLKTIGRFDSEAHCGEI--- 107 Query: 302 EFSTHVDGVVVSSGSD-NRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL 360 DG V+ +G D R+ ++D+ Q H+ V Sbjct: 108 ----RPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHI-----------HKQPVWVTKW 152 Query: 361 NPQIPWLVASAEEENILQVWKCSHSLP 387 +P + S ++ +++W + P Sbjct: 153 SPTELTTLMSCSDDKTVRLWDLPSNDP 179 >3MKQ-A nrPDB Length = 814 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 50/266 (18%), Positives = 101/266 (37%), Gaps = 26/266 (9%) Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEGL-QSTLKFHKDNGYALSFSTLVKGRLLSG 179 + + P +P V T G V +++ + +++ + A F K ++ G Sbjct: 16 VKGIDFHPTEP-WVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIAR-KNWIIVG 73 Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVR 239 SDD + ++ +G + H D I H + + S+D +K+ + Sbjct: 74 SDDFRIRVFNYNTGEKVVDF-----EAHPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWE 127 Query: 240 ANNTTIDTV-KCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAV 298 N T +AF+ + A+ +D V ++ L +G E V Sbjct: 128 NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGV 187 Query: 299 NNLEFSTHVDGVVVSSGSDN-RLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVND 357 N +++ D + + SD+ + +WD + T + GH S+V+ Sbjct: 188 NYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLE--------------GHMSNVSF 233 Query: 358 FDLNPQIPWLVASAEEENILQVWKCS 383 +P +P ++ S E+ L++W S Sbjct: 234 AVFHPTLP-IIISGSEDGTLKIWNSS 258 Score = 117 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 77/222 (34%), Gaps = 10/222 (4%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG--LQSTLKFHKDNGYALSFSTLVKG 174 H + I P P ++ + + TV L++ L+ T + H+ ++F+ Sbjct: 96 HPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPS 154 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN-FNKDLFGTVSEDSLL 233 SG D TV +W +G + P T +N ++ +K T S+D + Sbjct: 155 TFASGCLDRTVKVWSLG----QSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTI 210 Query: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 KI D + + + F ++ + D + +++ K ++ Sbjct: 211 KIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWNSSTYKVE-KTLNV 268 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD 335 + + ++SG DN + L + D Sbjct: 269 GLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLD 310 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 43/273 (15%), Positives = 94/273 (34%), Gaps = 13/273 (4%) Query: 132 NIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEV 190 N + + + +++ + G + H D +++ +LSGSDD TV LW Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNW 126 Query: 191 GSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTID-TVK 249 + +T+ H + ++ + F + D +K+ + + T Sbjct: 127 ENNW---ALEQTFEG-HEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 250 CPQPFNTLAFSH-HSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVD 308 + N + + + A D + ++D + K + + GH V+ F + Sbjct: 183 QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT-KSCVATLEGHMSNVSFAVFHPTL- 240 Query: 309 GVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLV 368 +++S D L +W+ E+T + + + G ++ + + V Sbjct: 241 PIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGF---DNGFTV 297 Query: 369 ASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS 401 S + L GG DI + Sbjct: 298 LSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFT 330 Score = 92.2 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 68/192 (35%), Gaps = 14/192 (7%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTL-KFHKDNGYALSFSTLVK 173 HE + + P+DP+ A+ TV ++S + TL + + + L Sbjct: 138 GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPD 197 Query: 174 G-RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSL 232 +++ SDD T+ +W+ V T S++ + + + SED Sbjct: 198 KPYMITASDDLTIKIWD----YQTKSCVATLEGHMSNV--SFAVFHPTLPIIISGSEDGT 251 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 LKI + + +A A+G D+ + L N EP + Sbjct: 252 LKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGN-DEPTLSL- 309 Query: 293 GHEDAVNNLEFS 304 D V L +S Sbjct: 310 ---DPVGKLVWS 318 Score = 89.1 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 30/188 (15%), Positives = 58/188 (30%), Gaps = 17/188 (9%) Query: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAF 259 ++ SD + +H + T+ ++I + P F Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTL-YSGRVEIWNYETQVEVRSIQVTETPVRAGKF 63 Query: 260 SHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNR 319 N + D + +++ N E + H D + ++ V+S D Sbjct: 64 IARK-NWIIVGSDDFRIRVFNY-NTGEKVVDFEAHPDYIRSIAVHPTK-PYVLSGSDDLT 120 Query: 320 LMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 + +W+ + A + GH V NP+ P AS + ++V Sbjct: 121 VKLWNWENNWALEQ-------------TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKV 167 Query: 380 WKCSHSLP 387 W S P Sbjct: 168 WSLGQSTP 175 >6HHQ-h nrPDB Length = 319 Score = 138 bits (347), Expect = 5e-33, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 92/269 (34%), Gaps = 36/269 (13%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQS------TLKFHKDNGYALSFS 169 H +T PN++ + + T+ + + Q + K H + Sbjct: 15 GHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTL- 73 Query: 170 TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 T LS S D T+ LW+V +G + V +D+ S I + + + S Sbjct: 74 TADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDI------DKKASMIISGSR 127 Query: 230 DSLLKINDVRANNTTIDTVKCPQPFNTLAFSHH-----SSNLLAAAGMDSYVYLYDLRNM 284 D +K+ ++ + + + + S + +AG D V ++L Sbjct: 128 DKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQF 186 Query: 285 KEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 + + GH +N L S ++ S+G D +M+W+L A T + Sbjct: 187 QIEADFI-GHNSNINTLTASP-DGTLIASAGKDGEIMLWNLAAKKAMYTLSAQD------ 238 Query: 345 IMVHAGHRSSVNDFDLNPQIPWLVASAEE 373 V +P WL A+ Sbjct: 239 ---------EVFSLAFSPNRYWLAAATAT 258 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 49/238 (20%), Positives = 97/238 (40%), Gaps = 26/238 (10%) Query: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGG-DPTKPVRTWNDLHSDI 210 L+ TL+ H +L+ S LLS S D T+ W++ PVR++ HS I Sbjct: 9 LRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKG-HSHI 67 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 + D + + S D L++ DV T V ++ ++++ + Sbjct: 68 VQDCT-LTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDID-KKASMIISG 125 Query: 271 GMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG-----VVVSSGSDNRLMMWDL 325 D + ++ ++ + L + GH D V+ + + ++S+G+D + W+L Sbjct: 126 SRDKTIKVWTIK--GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNL 183 Query: 326 KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 Q ++ GH S++N +P L+ASA ++ + +W + Sbjct: 184 NQF--------------QIEADFIGHNSNINTLTASPDGT-LIASAGKDGEIMLWNLA 226 >2YNP-A nrPDB Length = 604 Score = 136 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 51/266 (19%), Positives = 101/266 (37%), Gaps = 26/266 (9%) Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEGL-QSTLKFHKDNGYALSFSTLVKGRLLSG 179 + + P +P V T G V L++ + +++ + A F K ++ G Sbjct: 16 VKGIDFHPTEP-WVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIAR-KNWIIVG 73 Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVR 239 SDD + ++ +G + H D I H + + S+D +K+ + Sbjct: 74 SDDFRIRVFNYNTGEKVVDF-----EAHPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWE 127 Query: 240 ANNTTIDTV-KCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAV 298 N T +AF+ + A+ +D V ++ L +G E V Sbjct: 128 NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGV 187 Query: 299 NNLEFSTHVDGVVVSSGSDN-RLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVND 357 N +++ D + + SD+ + +WD + T + GH S+V+ Sbjct: 188 NYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLE--------------GHMSNVSF 233 Query: 358 FDLNPQIPWLVASAEEENILQVWKCS 383 +P +P ++ S E+ L++W S Sbjct: 234 AVFHPTLP-IIISGSEDGTLKIWNSS 258 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 77/222 (34%), Gaps = 10/222 (4%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG--LQSTLKFHKDNGYALSFSTLVKG 174 H + I P P ++ + + TV L++ L+ T + H+ ++F+ Sbjct: 96 HPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPS 154 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN-FNKDLFGTVSEDSLL 233 SG D TV +W +G + P T +N ++ +K T S+D + Sbjct: 155 TFASGCLDRTVKVWSLG----QSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTI 210 Query: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 KI D + + + F ++ + D + +++ K ++ Sbjct: 211 KIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWNSSTYKVE-KTLNV 268 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD 335 + + ++SG DN + L + D Sbjct: 269 GLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLD 310 Score = 111 bits (277), Expect = 6e-25, Method: Composition-based stats. Identities = 43/273 (15%), Positives = 94/273 (34%), Gaps = 13/273 (4%) Query: 132 NIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEV 190 N + + + +++ + G + H D +++ +LSGSDD TV LW Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNW 126 Query: 191 GSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTID-TVK 249 + +T+ H + ++ + F + D +K+ + + T Sbjct: 127 ENNW---ALEQTFEG-HEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 250 CPQPFNTLAFSH-HSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVD 308 + N + + + A D + ++D + K + + GH V+ F + Sbjct: 183 QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT-KSCVATLEGHMSNVSFAVFHPTL- 240 Query: 309 GVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLV 368 +++S D L +W+ E+T + + + G ++ + + V Sbjct: 241 PIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGF---DNGFTV 297 Query: 369 ASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS 401 S + L GG DI + Sbjct: 298 LSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFT 330 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 69/192 (35%), Gaps = 14/192 (7%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTL-KFHKDNGYALSFSTLVK 173 HE + + P+DP+ A+ TV ++S + TL + + + L Sbjct: 138 GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPD 197 Query: 174 G-RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSL 232 +++ SDD T+ +W+ + V T S++ + + + SED Sbjct: 198 KPYMITASDDLTIKIWDYQTKS----CVATLEGHMSNV--SFAVFHPTLPIIISGSEDGT 251 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 LKI + + +A A+G D+ + L N EP + Sbjct: 252 LKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGN-DEPTLSL- 309 Query: 293 GHEDAVNNLEFS 304 D V L +S Sbjct: 310 ---DPVGKLVWS 318 Score = 87.5 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 29/188 (15%), Positives = 58/188 (30%), Gaps = 17/188 (9%) Query: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAF 259 ++ SD + +H + T+ +++ + P F Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTL-YSGRVELWNYETQVEVRSIQVTETPVRAGKF 63 Query: 260 SHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNR 319 N + D + +++ N E + H D + ++ V+S D Sbjct: 64 IARK-NWIIVGSDDFRIRVFNY-NTGEKVVDFEAHPDYIRSIAVHPTK-PYVLSGSDDLT 120 Query: 320 LMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 + +W+ + A + GH V NP+ P AS + ++V Sbjct: 121 VKLWNWENNWALEQ-------------TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKV 167 Query: 380 WKCSHSLP 387 W S P Sbjct: 168 WSLGQSTP 175 >5GAN-H nrPDB Length = 465 Score = 134 bits (336), Expect = 8e-32, Method: Composition-based stats. Identities = 50/273 (18%), Positives = 98/273 (35%), Gaps = 32/273 (11%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-----LQSTLKFHKDNGYALSFSTL 171 H +I + P N + + G + + S L L H+ + + Sbjct: 217 HVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHP- 275 Query: 172 VKGRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED 230 G+ + S S D T LW+ + + + S + L + D Sbjct: 276 -SGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCD------GSLVCSGGMD 328 Query: 231 SLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE-PLH 289 SL + D+R+ + + +P T+A+S + +A G D + ++D+R E L+ Sbjct: 329 SLSMLWDIRSGSKVMTLAGHSKPIYTVAWSP-NGYQVATGGGDGIINVWDIRKRDEGQLN 387 Query: 290 HMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVH 348 + H + V + FS G +VS G DN + ++ + Sbjct: 388 QILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVY--------------SSDTWLKMGSL 433 Query: 349 AGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 AGH + D++ + S + +++W Sbjct: 434 AGHTDKIISLDIS-NNSHFLVSGGWDRSIKLWN 465 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 45/215 (20%), Positives = 81/215 (37%), Gaps = 14/215 (6%) Query: 114 KYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTL-KFHKDNGYALSFSTLV 172 HE I+ +Y P + + + T L+ S + L + H ++LSF Sbjct: 261 LVGHERRISDVKYHPS-GKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQ-CD 318 Query: 173 KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSL 232 + SG D LW++ SG HS I W N T D + Sbjct: 319 GSLVCSGGMDSLSMLWDIRSGSKVMTL-----AGHSKPIYTVAWSP-NGYQVATGGGDGI 372 Query: 233 LKINDVRANNTTI--DTVKCPQPFNTLAFSHHSSNL-LAAAGMDSYVYLYDLRNMKEPLH 289 + + D+R + + + FS L + G D+ + +Y + + Sbjct: 373 INVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYS-SDTWLKMG 431 Query: 290 HMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD 324 ++GH D + +L+ S + +VS G D + +W+ Sbjct: 432 SLAGHTDKIISLDIS-NNSHFLVSGGWDRSIKLWN 465 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 17/133 (12%), Positives = 49/133 (36%), Gaps = 12/133 (9%) Query: 251 PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGV 310 +P + ++ S ++A + + + + ++ + H + +++ + Sbjct: 175 TKPISAVSLS-TDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQ 233 Query: 311 VVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVAS 370 ++S D + + E+G L+ GH ++D +P + + S Sbjct: 234 MISCAEDGLIKNFQYSN----------EEGGLRLLGDLVGHERRISDVKYHPSGKF-IGS 282 Query: 371 AEEENILQVWKCS 383 A + ++W S Sbjct: 283 ASHDMTWRLWDAS 295 >6ID0-T nrPDB Length = 514 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 59/369 (15%), Positives = 119/369 (32%), Gaps = 61/369 (16%) Query: 44 PTPVQELDGGFIKQELIIGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQ---- 99 P P L Q + S L A LP + ++ + +G EY+ Sbjct: 102 PGPGVALTADTKIQRM-----PSESAAQSLAVA---LPLQTKADANRTAPSGSEYRHPGA 153 Query: 100 SSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFH 159 S P P + I + + ++ ++A + L + H Sbjct: 154 SDRPQPTAMNSIVMETGNT----------KNSALMAKKAPTMPKPQWHPPWKLYRVISGH 203 Query: 160 KDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNF 219 ++ + ++GS D T+ +W++ SG ++ H + Sbjct: 204 LGWVRCIAVEPGNQ-WFVTGSADRTIKIWDLASG-----KLKLSLTGHISTVRGVIVSTR 257 Query: 220 NKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY 279 + LF + ED +K D+ N L ++L DS ++ Sbjct: 258 SPYLF-SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI-DVLVTCSRDSTARIW 315 Query: 280 DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAED 339 D+R K +H +SGH +AV + + +++ D + +WDL T + + Sbjct: 316 DVRT-KASVHTLSGHTNAVATVR-CQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKK 373 Query: 340 GVPELIMVHA---------------------------GHRSSVNDFDLNPQIPWLVASAE 372 V +++ GH + +N +N ++ S Sbjct: 374 SVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSGA 431 Query: 373 EENILQVWK 381 + + +W Sbjct: 432 DNGTMHLWD 440 Score = 107 bits (267), Expect = 9e-24, Method: Composition-based stats. Identities = 44/308 (14%), Positives = 97/308 (31%), Gaps = 61/308 (19%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQS-TLKFHKDNGYALSFSTLVK 173 H + P + T + T+ ++ + G +L H + ST Sbjct: 201 SGHLGWVRCIAVEPGN-QWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSP 259 Query: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDL--------------------------- 206 L S +D V W++ + K +R ++ Sbjct: 260 -YLFSCGEDKQVKCWDL----EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314 Query: 207 --------------HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQ 252 H++ + + + T S D+ +++ D+ A T + + Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTRVTLTNHKK 373 Query: 253 PFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVV 312 + A+ D+ + + + + ++SGH +N L ++ DGV+V Sbjct: 374 SVRAVVLHPRH-YTFASGSPDN-IKQWKFPD-GSFIQNLSGHNAIINTLTVNS--DGVLV 428 Query: 313 SSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAE 372 S + + +WD + Q A S + + L+ +AE Sbjct: 429 SGADNGTMHLWDWRTGYNFQRVHAAVQPGS------LDSESGIFACAFDQSESRLL-TAE 481 Query: 373 EENILQVW 380 + ++V+ Sbjct: 482 ADKTIKVY 489 Score = 36.3 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 9/50 (18%), Positives = 18/50 (36%), Gaps = 1/50 (2%) Query: 334 PDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 P +L V +GH V + P W + + +++W + Sbjct: 186 PKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQW-FVTGSADRTIKIWDLA 234 >5WYJ-BC nrPDB Length = 817 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 57/336 (16%), Positives = 111/336 (33%), Gaps = 39/336 (11%) Query: 65 TSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSN-----IRITAKYEHEE 119 TS N+ A++ L+ + +P + + HE+ Sbjct: 330 TSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHED 389 Query: 120 EITRARYMPQDPNIVATINGQGTVFLYSRSE-----GLQSTLKFHKDNGYALSF----ST 170 + +D +AT + T ++ +E + + H A+ S Sbjct: 390 LLNSLDAT-EDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSK 448 Query: 171 LVKGRLLSGSDDHTVALWEVG--SGGDPTKPVRTWN---DLHSDIINDNKWHNFNKDLFG 225 LL+ S+D T+ W + + + ++ H IN N +F Sbjct: 449 GYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP-NDSIFA 507 Query: 226 TVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMK 285 T S D KI ++ + ++F + LLA + D V ++ L Sbjct: 508 TASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYD-KLLATSSGDKTVKIWSLDTFS 566 Query: 286 EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELI 345 + + GH +AV F + ++S G+D + +WD E + Sbjct: 567 V-MKTLEGHTNAVQRCSFI-NKQKQLISCGADGLIKIWDCS--------------SGECL 610 Query: 346 MVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 GH + + ++ SA+ + + Q WK Sbjct: 611 KTLDGHNNRLWALSTMNDGD-MIVSADADGVFQFWK 645 Score = 104 bits (258), Expect = 9e-23, Method: Composition-based stats. Identities = 51/312 (16%), Positives = 110/312 (35%), Gaps = 46/312 (14%) Query: 97 EYQSSLPAPRSNIRITAKY-EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSE--GLQ 153 + L I++T+ + I RY+ + N +A ++ + + G + Sbjct: 315 NVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPE 374 Query: 154 STL-------KFHKDNGYALSFSTLVKGR-LLSGSDDHTVALWEVGSGGDPTKPVRTWND 205 ++L + H+D +L G + + S D+T +W + Sbjct: 375 ASLPLDVEIYEGHEDLLNSL--DATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKY-I 431 Query: 206 LHSDIINDNKWHNF----NKDLFGTVSEDSLLKINDVRANNTTIDT----------VKCP 251 HS + N + T S D +K + ++D Sbjct: 432 GHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHE 491 Query: 252 QPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVV 311 + N L+ S + S + A A D +++L N + ++ H+ + ++ F D ++ Sbjct: 492 KDINALSVSPNDS-IFATASYDKTCKIWNLENGELE-ATLANHKRGLWDVSFC-QYDKLL 548 Query: 312 VSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASA 371 +S D + +W L +T + GH ++V + L+ S Sbjct: 549 ATSSGDKTVKIWSLDTFSVMKTLE--------------GHTNAVQRCSFINKQKQLI-SC 593 Query: 372 EEENILQVWKCS 383 + ++++W CS Sbjct: 594 GADGLIKIWDCS 605 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 45/290 (15%), Positives = 99/290 (34%), Gaps = 31/290 (10%) Query: 116 EHEEEITRARYMPQ-DPNI--VATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSF--- 168 H I+ ++ Q + I +A+ + G V ++ TL+ H L Sbjct: 142 GHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEV 201 Query: 169 --STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFN--KDLF 224 + LLSG D + LW+ + + + K + Sbjct: 202 PDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQ---VESCGFLKDGDGKRII 258 Query: 225 GTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSH--HSSNLLAAAGMDSYVYLY--- 279 T D++ ++ D + + T K + + +S + D + L Sbjct: 259 YTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLS-DQTLQLINVE 317 Query: 280 -DLRNMKEPLHH---MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD 335 DL+N ++ + ++G+ + ++ + + + + L I Sbjct: 318 EDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLR------IIPVPDLS 371 Query: 336 DAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 E +P + ++ GH +N D W +A+A ++N VW+ + + Sbjct: 372 GPEASLPLDVEIYEGHEDLLNSLDATEDGLW-IATASKDNTAIVWRYNEN 420 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 39/216 (18%), Positives = 78/216 (36%), Gaps = 20/216 (9%) Query: 122 TRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLK--FHKDNGYALSFSTLVKGRLLS- 178 + + ++ I+AT + + G + L ++D + G+ L+ Sbjct: 20 SAVATVSENGKILATPVLDEINII-DLTPGSRKILHKISNEDEQEITALKLTPDGQYLTY 78 Query: 179 GSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDV 238 S + ++ + +G K VR+ I D L D + + D+ Sbjct: 79 VSQAQLLKIFHLKTG----KVVRSMKISSPSYILDAD---STSTLLAVGGTDGSIIVVDI 131 Query: 239 RANNTTIDTVKCPQPFNTLAFSHHSSN---LLAAAGMDSYVYLYDLRNMKEPLHHMSGHE 295 T ++L F ++ LLA+ + V ++DL ++ LH + H Sbjct: 132 ENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVK-RKCLHTLQEHT 190 Query: 296 DAVNNLEF--STHVDGV---VVSSGSDNRLMMWDLK 326 AV L+ D ++S G D+ + +WD Sbjct: 191 SAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFN 226 >3JAP-g nrPDB Length = 326 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 46/274 (16%), Positives = 91/274 (33%), Gaps = 40/274 (14%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQ------STLKFHKDNGYALSFS 169 H +T PN++ + + T+ + +E Q + K H + S Sbjct: 16 GHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVS 75 Query: 170 TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 +S S D T+ LW + +G + V D+ S I + N + S Sbjct: 76 A-DGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAI------DANSSKIISASR 128 Query: 230 DSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN---------LLAAAGMDSYVYLYD 280 D +++ + + + + + + +AGMD V + Sbjct: 129 DKTIRVWNT-VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWS 187 Query: 281 LRNMKEPL-HHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAED 339 L + GH + +N ++ S + S+G D ++ +W+LK A Sbjct: 188 LNEDSYRIEADFIGHNNYINVVQPSP-DGSLAASAGKDGQIYVWNLKHKSA--------- 237 Query: 340 GVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEE 373 ++ + V +P WL A+ Sbjct: 238 ------FMNFDAKDEVFALAFSPSRFWLTAATAS 265 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 54/243 (22%), Positives = 99/243 (40%), Gaps = 28/243 (11%) Query: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDP-TKPVRTWNDLHSDI 210 L+ TL+ H +LS S L+SGS D T+ W + PVR++ HS I Sbjct: 10 LRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKG-HSHI 68 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 + D + + + + S D L++ ++ N+ V ++A +SS ++ +A Sbjct: 69 VQDV-VVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKII-SA 126 Query: 271 GMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTH-------VDGVV--VSSGSDNRLM 321 D + +++ + + + + GH D V + + DG + VS+G D + Sbjct: 127 SRDKTIRVWN--TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVR 184 Query: 322 MWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 W L + + GH + +N +P L ASA ++ + VW Sbjct: 185 SWSLNEDSY------------RIEADFIGHNNYINVVQPSPDGS-LAASAGKDGQIYVWN 231 Query: 382 CSH 384 H Sbjct: 232 LKH 234 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 30/208 (14%), Positives = 59/208 (28%), Gaps = 32/208 (15%) Query: 192 SGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNT-----TID 246 S + +R + H+ + +L + S D L + N Sbjct: 2 SSSNIMLVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRS 61 Query: 247 TVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTH 306 + S N +A D + L++L + GH V ++ + Sbjct: 62 YKGHSHIVQDVVVS-ADGNYAVSASWDKTLRLWNLATGNSEARFV-GHTGDVLSVAIDAN 119 Query: 307 VDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNP---- 362 ++ S+ D + +W + V + V GH V + P Sbjct: 120 SSKII-SASRDKTIRVW---------------NTVGDCAYVLLGHTDWVTKVRVAPKNLE 163 Query: 363 -----QIPWLVASAEEENILQVWKCSHS 385 SA + I++ W + Sbjct: 164 DGEVDDGRITFVSAGMDKIVRSWSLNED 191 Score = 54.4 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 29/193 (15%), Positives = 57/193 (29%), Gaps = 30/193 (15%) Query: 113 AKYEHEEEITRARYMPQDPN---------IVATINGQGTVFLYSRSEG---LQSTLKFHK 160 H + +T+ R P++ + V +S +E +++ H Sbjct: 144 VLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHN 203 Query: 161 DNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFN 220 + + S S D + +W + N D + + Sbjct: 204 NYINVVQPSP-DGSLAASAGKDGQIYVWNLKHKSAF------MNFDAKDEVFALAFSP-- 254 Query: 221 KDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHH--------SSNLLAAAGM 272 + T + S +KI D+ N ID +K T A H L A Sbjct: 255 SRFWLTAATASGIKIYDLE-NEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYT 313 Query: 273 DSYVYLYDLRNMK 285 D+ + ++ + Sbjct: 314 DNVIRVWQVMTAN 326 Score = 32.8 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 18/51 (35%) Query: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNK 397 GH V + P L+ S + L W+ + + G P + K Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYK 63 >4V7E-Bg nrPDB Length = 380 Score = 131 bits (328), Expect = 8e-31, Method: Composition-based stats. Identities = 51/354 (14%), Positives = 112/354 (31%), Gaps = 53/354 (14%) Query: 84 ILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTV 143 +L + + + + P + H ++ + P+ N + + + G + Sbjct: 32 LLDTDVEKYSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEK-NWIVSASQDGRL 90 Query: 144 FLYSR-SEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPT--KPV 200 +++ + +K H +F+ + + G D +++ + S D PV Sbjct: 91 IVWNALTSQKTHAIKLHCPWVMECAFAPNGQS-VACGGLDSACSIFNLSSQADRDGNMPV 149 Query: 201 RTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDT-----VKCPQPFN 255 H + ++ + T S D + DV Sbjct: 150 SRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVL 209 Query: 256 TLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSG 315 +L+ + ++N+ + D+ V L+DLR + GHE +N+++F DG +G Sbjct: 210 SLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFP--DGQRFGTG 267 Query: 316 SDN-RLMMWDLKQIGAEQ---------------TPDDAEDGVPELIM------------- 346 SD+ ++D++ Q A L+ Sbjct: 268 SDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDT 327 Query: 347 -----------VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIV 389 + H ++ L+ L + + L++W S IV Sbjct: 328 LLAEMVLNLGTLQNSHEGRISCLGLSSDGSAL-CTGSWDKNLKIWAFSGHRKIV 380 >4BTS-AR nrPDB Length = 343 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 45/291 (15%), Positives = 104/291 (35%), Gaps = 52/291 (17%) Query: 116 EHEEEITRARY-----MPQDPNIVATINGQGTVFLYSRSEGLQ--------STLKFHKDN 162 H + +T +D ++ + + TV ++ E Q L H Sbjct: 19 GHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHF 78 Query: 163 GYALSFSTLVKGRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNK 221 L+ S + S S D T+ LW++ +G + V H + + N+ Sbjct: 79 VSDLALS--QENCFAISSSWDKTLRLWDLRTGTTYKRFV-----GHQSEVYSVAFSPDNR 131 Query: 222 DLFGTVSEDSLLKINDV--RANNTTIDTVKCPQPFNTLAFSHHSSN---------LLAAA 270 + + + +K+ ++ ++ + + + +S + A+ Sbjct: 132 QIL-SAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASV 190 Query: 271 GMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGA 330 G D + +++ + + HE VN+L S + + G D +L++WD+ + Sbjct: 191 GWDGRLKVWN--TNFQIRYTFKAHESNVNHLSISP-NGKYIATGGKDKKLLIWDILNLTY 247 Query: 331 EQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 Q DA S++N NP++ W+ + + ++++ Sbjct: 248 PQREFDAG--------------STINQIAFNPKLQWV--AVGTDQGVKIFN 282 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 48/244 (19%), Positives = 88/244 (36%), Gaps = 35/244 (14%) Query: 156 LKFHKDNGYALSFSTLVKGR-----LLSGSDDHTVALWEVGSGGDPTKPVRTWN--DLHS 208 L+ H D ++ K L+SGS D TV +W++ H+ Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 209 DIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLA 268 ++D N + S D L++ D+R T V ++AFS + +L Sbjct: 77 HFVSDLALSQENC-FAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQIL- 134 Query: 269 AAGMDSYVYLYDLRN-MKEPLHHMSGHEDAVNNLEFST---------HVDGVVVSSGSDN 318 +AG + + L+++ K H D V+ + +S S G D Sbjct: 135 SAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDG 194 Query: 319 RLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQ 378 RL +W + ++ H S+VN ++P + +A+ ++ L Sbjct: 195 RLKVW---------------NTNFQIRYTFKAHESNVNHLSISPNGKY-IATGGKDKKLL 238 Query: 379 VWKC 382 +W Sbjct: 239 IWDI 242 Score = 78.7 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 39/284 (13%), Positives = 86/284 (30%), Gaps = 40/284 (14%) Query: 64 HTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITR 123 H + N+ +++ L +E + L R+ H+ E+ Sbjct: 69 HKALTGHNHF-VSDLALSQENCFAISSSWDKTLR----LWDLRTGTTYKRFVGHQSEVYS 123 Query: 124 ARYMPQDPNIVATINGQGTVFLYSRSEGL---QSTLKFHKDNGYALSFSTLVKG------ 174 + P + I+ + + + L++ + + H D + +S ++K Sbjct: 124 VAFSPDNRQIL-SAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQP 182 Query: 175 ---RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 S D + +W +R H +N N T +D Sbjct: 183 FAPYFASVGWDGRLKVWNTNFQ------IRYTFKAHESNVNHLSISP-NGKYIATGGKDK 235 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN-MKEPLHH 290 L I D+ N +AF+ +A D V +++L K P+ Sbjct: 236 KLLIWDILNLTYPQREFDAGSTINQIAFNPKL-QWVAVGT-DQGVKIFNLMTQSKAPVCT 293 Query: 291 MS-----------GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 + G +L ++ + + + +D + + Sbjct: 294 IEAEPITKAEGQKGKNPQCTSLAWN-ALGKKLFAGFTDGVIRTF 336 Score = 50.2 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 42/97 (43%), Gaps = 13/97 (13%) Query: 290 HMSGHEDAVNNL--EFST---HVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 + GH D V ++ FS V++S D +M+W L + + G+P Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKL-----YEEEQNGYFGIPHK 70 Query: 345 IMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 + GH V+D L+ + + + S+ + L++W Sbjct: 71 ALT--GHNHFVSDLALSQENCFAI-SSSWDKTLRLWD 104 >4YCZ-A nrPDB Length = 876 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 47/254 (18%), Positives = 85/254 (33%), Gaps = 35/254 (13%) Query: 157 KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW 216 H D + RL + S D T+ ++E+ T+ + H + W Sbjct: 15 SGHDDMIHDAVLD-YYGRRLATCSSDRTIKIFEIEG---ETQRLTETLKGHDGAVWCVSW 70 Query: 217 -HNFNKDLFGTVSEDSLLKIN-DVRANNTTI-DTVKCPQPFNTLAFSHHS-SNLLAAAGM 272 H ++ + D + I ++ I D N +++S H LLA A Sbjct: 71 AHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASS 130 Query: 273 DSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFST----------------HVDGVVVSSGS 316 D V + + R+ H VN++ ++ + V+ GS Sbjct: 131 DGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGS 190 Query: 317 DNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI--PWLVASAEEE 374 DN L +W + GH V D +P + +ASA E+ Sbjct: 191 DNALKIWAYDPATNTYKLEREP---------LTGHTDWVRDVAWSPTVLQKSYIASASED 241 Query: 375 NILQVWKCSHSLPI 388 +++W + P+ Sbjct: 242 RTVRIWTSDPANPL 255 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 47/307 (15%), Positives = 96/307 (31%), Gaps = 44/307 (14%) Query: 103 PAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQS---TLKFH 159 + + ++ A H+ ++ + +AT + T+ ++ Q TLK H Sbjct: 3 GSMAAGTQVIANSGHD-DMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGH 61 Query: 160 KDNGYALSFS-TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN 218 + +S++ L S D V +W +G H +N W Sbjct: 62 DGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFAL---HKASVNVVSWSP 118 Query: 219 FNKD-LFGTVSEDSLLKINDVRAN-NTTIDTVKCPQPFNTLAFSH--------------- 261 L S D + + + R N N+++++ Sbjct: 119 HEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPK 178 Query: 262 -HSSNLLAAAGMDSYVYLY--DLRNMKEPLHH--MSGHEDAVNNLEFSTHV--DGVVVSS 314 + G D+ + ++ D L ++GH D V ++ +S V + S+ Sbjct: 179 STGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASA 238 Query: 315 GSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEE 374 D + +W Q + ++V + L AS + Sbjct: 239 SEDRTVRIWTSDPANPLQWNCKVLN-----------FDAAVWRVSWSLSGNVLAASGG-D 286 Query: 375 NILQVWK 381 N + +WK Sbjct: 287 NKVTLWK 293 Score = 97.6 bits (241), Expect = 9e-21, Method: Composition-based stats. Identities = 35/202 (17%), Positives = 72/202 (35%), Gaps = 27/202 (13%) Query: 117 HEEEITRARYMPQD-PNIVATINGQGTVFL--YSRSEGLQSTLKFHKDNGYALSFST--- 170 H+ + + P + ++A + G V + + + S H ++S++ Sbjct: 107 HKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATS 166 Query: 171 -------------LVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 R ++G D+ + +W + K R H+D + D W Sbjct: 167 PGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWS 226 Query: 218 N--FNKDLFGTVSEDSLLKINDVRAN---NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM 272 K + SED ++I + +++S S N+LAA+G Sbjct: 227 PTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWS-LSGNVLAASGG 285 Query: 273 DSYVYLY--DLRNMKEPLHHMS 292 D+ V L+ +L+ E + + Sbjct: 286 DNKVTLWKENLKGEWECVKTIE 307 >5UZ7-B nrPDB Length = 351 Score = 117 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 54/227 (23%), Positives = 97/227 (42%), Gaps = 16/227 (7%) Query: 102 LPAPRSNIRITAKY-EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKF-H 159 L N+R++ + H ++ R++ D N + T +G T L+ G Q+T H Sbjct: 137 LKTREGNVRVSRELAGHTGYLSCCRFL--DDNQIVTSSGDTTCALWDIETGQQTTTFTGH 194 Query: 160 KDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNF 219 + +LS + + +SG+ D + LW+V G R H IN + Sbjct: 195 TGDVMSLSLAPDTR-LFVSGACDASAKLWDVREG-----MCRQTFTGHESDINAICFFP- 247 Query: 220 NKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS-YVYL 278 N + F T S+D+ ++ D+RA+ + + S S L AG D + Sbjct: 248 NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNV 307 Query: 279 YDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSG-SDNRLMMWD 324 +D ++GH++ V+ L DG+ V++G D+ L +W+ Sbjct: 308 WDALKADRA-GVLAGHDNRVSCLGV--TDDGMAVATGSWDSFLKIWN 351 Score = 107 bits (267), Expect = 9e-24, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 77/232 (33%), Gaps = 30/232 (12%) Query: 154 STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIIND 213 TL+ H YA+ + T L+S S D + +W+ + L S + Sbjct: 60 RTLRGHLAKIYAMHWGT-DSRLLVSASQDGKLIIWDSYTTNKVHAI-----PLRSSWVMT 113 Query: 214 NKWHNFNKDLFGTVSEDSLLKINDVRANNT----TIDTVKCPQPFNTLAFSHHSSNLLAA 269 + + + D++ I +++ + + + F N + Sbjct: 114 CAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL--DDNQIVT 170 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG 329 + D+ L+D+ ++ H V +L + + VS D +WD+++ Sbjct: 171 SSGDTTCALWDIETGQQTTTFTG-HTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGM 228 Query: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 QT GH S +N P A+ ++ +++ Sbjct: 229 CRQT--------------FTGHESDINAICFFPNGN-AFATGSDDATCRLFD 265 >6Q8F-A nrPDB Length = 514 Score = 117 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 48/315 (15%), Positives = 113/315 (35%), Gaps = 55/315 (17%) Query: 113 AKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFH--------KDNG 163 K+ + + AR+ P D + T + G + +++ + G ++ LK+ D Sbjct: 210 IKFGQKSHVECARFSP-DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 268 Query: 164 YALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDL 223 + FS + L +G+ D + +W++ SG + +R + HS + + + + Sbjct: 269 LCMCFSRDTE-MLATGAQDGKIKVWKIQSG----QCLRRFERAHSKGVTCLSFSKDSSQI 323 Query: 224 FGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN 283 + S D ++I+ +++ T + N F+ + + +A D V +++++ Sbjct: 324 L-SASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFT-QDGHYIISASSDGTVKIWNMKT 381 Query: 284 MKEPLHHMS------GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDA 337 E + G + VN++ V N +++ +++ Sbjct: 382 T-ECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGK 440 Query: 338 EDG------------------------------VPELIMVHAGHRSSVNDFDLNPQIPWL 367 +G +L H V +P L Sbjct: 441 REGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQN-L 499 Query: 368 VASAEEENILQVWKC 382 +A+ E+ +L++WK Sbjct: 500 IATYSEDGLLKLWKP 514 Score = 99.9 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 44/233 (18%), Positives = 84/233 (36%), Gaps = 17/233 (7%) Query: 158 FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGG---DPTKPVRTWNDLHSDIINDN 214 K + FS L++GS D + +W +G D + + D + Sbjct: 213 GQKSHVECARFSP-DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 271 Query: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTV-KCPQPFNTLAFSHHSSNLLAAAGMD 273 + + ++ T ++D +K+ +++ + L+FS SS +L +A D Sbjct: 272 CFS-RDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQIL-SASFD 329 Query: 274 SYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQT 333 + ++ L++ K L GH VN F T ++S+ SD + +W++K T Sbjct: 330 QTIRIHGLKSGKT-LKEFRGHSSFVNEATF-TQDGHYIISASSDGTVKIWNMKTTECSNT 387 Query: 334 PDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 I VN L P+ P N + + + Sbjct: 388 FKSLGSTAGTDIT--------VNSVILLPKNPEHFVVCNRSNTVVIMNMQGQI 432 Score = 91.0 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 31/203 (15%), Positives = 65/203 (32%), Gaps = 28/203 (13%) Query: 189 EVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTV 248 +V PT+ R + ++ + T S D +++ + D Sbjct: 196 DVEEEKFPTQLSRHIKFGQKSHVECARFSP-DGQYLVTGSVDGFIEVWNFTTGKIRKDLK 254 Query: 249 KCP--------QPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM-SGHEDAVN 299 + FS + +LA D + ++ ++ + L H V Sbjct: 255 YQAQDNFMMMDDAVLCMCFS-RDTEMLATGAQDGKIKVWKIQ-SGQCLRRFERAHSKGVT 312 Query: 300 NLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFD 359 L FS ++S+ D + + LK + + GH S VN+ Sbjct: 313 CLSFSK-DSSQILSASFDQTIRIHGLK--------------SGKTLKEFRGHSSFVNEAT 357 Query: 360 LNPQIPWLVASAEEENILQVWKC 382 +++ SA + +++W Sbjct: 358 FTQDGHYII-SASSDGTVKIWNM 379 >3W15-A nrPDB Length = 368 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 52/297 (17%), Positives = 117/297 (39%), Gaps = 40/297 (13%) Query: 125 RYMPQDPNIVATINGQGTVFLYSRS--EGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDD 182 + N V G GT+ L+ + E + K H+ ++ +++ + + LS S D Sbjct: 69 AWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWD 128 Query: 183 HTVALWE-------VGSGGDPTKPVRTWNDL---------------HSDIINDNKWHNFN 220 ++ +W + P + + + L + + + ++ + Sbjct: 129 GSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHD 188 Query: 221 KDLFGTVSEDSLLKINDVR--ANNTTIDTVKCPQ-PFNTLAFSHHSSNLLAAAGMDSYVY 277 ++L + S +S + D+R + + + T F+ + ++A G+D+ + Sbjct: 189 QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIR 248 Query: 278 LYDLRNMKE---------PLHHM-SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW-DLK 326 ++D+R + + ++ + + H A+ + +S H +++S+ D +W DL Sbjct: 249 IWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLS 308 Query: 327 QIGAEQTPD-DAEDGVPELIMVHAGHRSSVNDFDLNPQI-PWLVASAEEENILQVWK 381 GA++T ++ D I H V D + P VAS + L VW Sbjct: 309 NDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 43/308 (13%), Positives = 95/308 (30%), Gaps = 86/308 (27%) Query: 154 STLKFHKD--NGYALSFSTLVKGRLL--SGSDDHTV---ALWEVGSGGDPTKPVRTWNDL 206 S L++H +GY + +S RL +GS+ V L+ + + V + L Sbjct: 2 SMLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEI-DRSGRIVEVNSFL 60 Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVK-CPQPFNTLAFSHHSSN 265 D + D W+ +++ D L++ D I K + + ++ + Sbjct: 61 TQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQ 120 Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHM---------------------------SGHEDAV 298 ++ D + ++ K+ L + S + + V Sbjct: 121 NFLSSSWDGSIKIWSPLR-KQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 179 Query: 299 NNLEFSTHVDGVVVSS-------------------------------------------- 314 +FS H +V+S Sbjct: 180 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 239 Query: 315 --GSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAE 372 G DN + +WD++ + + P + + + H ++ +P ++ SA Sbjct: 240 TGGVDNAIRIWDIRMLN--KNPGQLHNSSC-INEIPNAHGLAIRKVTWSPHHSNILMSAS 296 Query: 373 EENILQVW 380 + ++W Sbjct: 297 YDMTCRIW 304 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 22/151 (14%), Positives = 50/151 (33%), Gaps = 13/151 (8%) Query: 245 IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFS 304 +++ LA++ N + A D + L+D + P+ HE V + ++ Sbjct: 56 VNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWN 115 Query: 305 THVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG-------------H 351 +SS D + +W + + T + +++ + Sbjct: 116 LVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 175 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 R+ V +P LV S + ++ Sbjct: 176 RNCVYQAQFSPHDQNLVLSCSGNSYASLFDI 206 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 23/161 (14%), Positives = 49/161 (30%), Gaps = 28/161 (17%) Query: 102 LPAPRSNIRITAKYEHEE-EITRARYMPQDPNIVATINGQGTVFLYSR-----------S 149 LP+ ++ H E + P +VAT + ++ + Sbjct: 208 LPSGKNQNNFLV---HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHN 264 Query: 150 EGLQSTLK-FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWN---- 204 + + H +++S L+S S D T +W S + +T + Sbjct: 265 SSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDAT 324 Query: 205 -------DLHSDIINDNKWHNFN-KDLFGTVSEDSLLKIND 237 HS+ + W + + + D L + + Sbjct: 325 KGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 >5K1B-B nrPDB Length = 677 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 90/236 (38%), Gaps = 29/236 (12%) Query: 157 KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW 216 K++++ AL + RL + D + +W V P + H+D +ND Sbjct: 27 KYNRNGVNALQLDPAL-NRLFTAGRDSIIRIWSVN--QHKQDPYIASMEHHTDWVNDIVL 83 Query: 217 HNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYV 276 K L + S D+ +K+ + LA++ L+A+AG+D + Sbjct: 84 CCNGKTLI-SASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYA-KDKELVASAGLDRQI 141 Query: 277 YLYDLR--------NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 +L+D+ N +SG++D++ +L + + ++VS ++ L +WD + Sbjct: 142 FLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMN-QLGTIIVSGSTEKVLRVWDPR-- 198 Query: 329 GAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 +M GH +V LN S + +++W Sbjct: 199 ------------TCAKLMKLKGHTDNVKALLLNRDGTQ-CLSGSSDGTIRLWSLGQ 241 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 54/300 (18%), Positives = 99/300 (33%), Gaps = 34/300 (11%) Query: 91 QEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSE 150 + + + + KY + + P N + T + ++S ++ Sbjct: 5 HRQNTAGRRKVQVSYVIRDEVE-KYNRNG-VNALQLDPA-LNRLFTAGRDSIIRIWSVNQ 61 Query: 151 GLQ----STLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDL 206 Q ++++ H D + L+S S D TV +W G + Sbjct: 62 HKQDPYIASMEHHTDWVNDIVL-CCNGKTLISASSDTTVKVWNAHKGFCMSTL-----RT 115 Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANN---------TTIDTVKCPQPFNTL 257 H D + + +K+L + D + + DV TT +L Sbjct: 116 HKDYVKALAY-AKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSL 174 Query: 258 AFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSD 317 A + ++ + + + ++D R L + GH D V L + +S SD Sbjct: 175 AMN-QLGTIIVSGSTEKVLRVWDPRTC-AKLMKLKGHTDNVKALLLN-RDGTQCLSGSSD 231 Query: 318 NRLMMWDLKQIGAEQTPDDAEDGVPEL----IMVH---AGHRSSVNDFDL-NPQIPWLVA 369 + +W L Q T ++GV L H G + DL NP I L+ Sbjct: 232 GTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLIC 291 >5WLC-LO nrPDB Length = 923 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 52/269 (19%), Positives = 107/269 (39%), Gaps = 18/269 (6%) Query: 95 GEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVA---TINGQGTVFLYSRSEG 151 P + I + + Q +A + GQ V+ + Sbjct: 280 TSGEFRLYDLPDFTL-IQQLSMGQNPVNTVSVN-QTGEWLAFGSSKLGQLLVYEWQSESY 337 Query: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII 211 + + H D+ +L++S R+++ S+D + +W++ SG + T+ H+ + Sbjct: 338 ILKQ-QGHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSGF----CLATFE-EHTSSV 390 Query: 212 NDNKWHNFNKDLFGTVSEDSLLKINDV-RANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 ++ + +F + S D ++ D+ R N T FN LA S ++ A Sbjct: 391 TAVQFAKRGQVMFSS-SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP-SGEVVCAG 448 Query: 271 GMDS-YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG 329 +D+ ++++ ++ + L +SGHE V+ L FS V+ S+ D + +W + Sbjct: 449 SLDNFDIHVWSVQTGQL-LDALSGHEGPVSCLSFSQEN-SVLASASWDKTIRIWSIFGRS 506 Query: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDF 358 + P + V L M G +V+ Sbjct: 507 QQVEPIEVYSDVLALSMRPDGKEVAVSTL 535 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 91/271 (33%), Gaps = 28/271 (10%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTLVK 173 Y ++ ++ + P ++A G LY L L ++ +S + + Sbjct: 257 YANQAKVKCVTFHPA-TRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGE 315 Query: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 S + ++E S K H D N + + T SED + Sbjct: 316 WLAFGSSKLGQLLVYEWQSESYILKQ-----QGHFDSTNSLAYSP-DGSRVVTASEDGKI 369 Query: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 K+ D+ + + + F+ ++ ++ +D V +DL + +G Sbjct: 370 KVWDITSGFCLATFEEHTSSVTAVQFA-KRGQVMFSSSLDGTVRAWDLIRYRN-FRTFTG 427 Query: 294 -HEDAVNNLEFSTHVDGVVVSSGSDN-RLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 N L + V DN + +W ++ +L+ +GH Sbjct: 428 TERIQFNCLAVDPSGEVVCA-GSLDNFDIHVWSVQ--------------TGQLLDALSGH 472 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 V+ + Q ++ASA + +++W Sbjct: 473 EGPVSCLSFS-QENSVLASASWDKTIRIWSI 502 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 93/272 (34%), Gaps = 44/272 (16%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG----LQSTLKFHKDNGYALSFSTL 171 H ++IT + QD + T + + ++S +T H+D FS Sbjct: 144 GHFQDITSLTWS-QDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHD 202 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 + ++ + S D V +WE + +D + ++ +K+ Sbjct: 203 QE-KIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYS-------------- 247 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 + + + F ++ LLA LYDL + + + Sbjct: 248 ----WRITKKHF---FYANQAKVKCVTFHP-ATRLLAVGFTSGEFRLYDLPDFTL-IQQL 298 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 S ++ VN + + + + S +L++++ + I+ GH Sbjct: 299 SMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSES--------------YILKQQGH 344 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 S N +P +V +A E+ ++VW + Sbjct: 345 FDSTNSLAYSPDGSRVV-TASEDGKIKVWDIT 375 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 30/182 (16%), Positives = 57/182 (31%), Gaps = 27/182 (14%) Query: 122 TRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLSGS 180 P + A + ++S G L L H+ LSFS L S S Sbjct: 434 NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASAS 492 Query: 181 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRA 240 D T+ +W + +P+ ++D+ + + + + I ++ Sbjct: 493 WDKTIRIWSIFGRSQQVEPIEVYSDVLALS------MRPDGKEVAVSTLKGQISIFNIED 546 Query: 241 NNTTIDTVKCPQP----FNTLAFSHHSSNL---------------LAAAGMDSYVYLYDL 281 + FN F+ +S + A G ++ + LYD+ Sbjct: 547 AKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDV 606 Query: 282 RN 283 N Sbjct: 607 PN 608 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 36/245 (14%), Positives = 73/245 (29%), Gaps = 32/245 (13%) Query: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN 218 H+ N A+ + L+S +D L + + +N + + K+ Sbjct: 54 HRKNIAAIDLN-KQGTLLISIDEDGRAILVNFKA----RNVLHHFNF--KEKCSAVKFSP 106 Query: 219 FNKDL-FGTVSEDSLLKINDVRANNTTIDTV------KCPQPFNTLAFSHHSSNLLAAAG 271 + + + K DV + V Q +L +S S +L Sbjct: 107 DGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTT-S 165 Query: 272 MDSYVYLY--DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ-- 327 D ++ D +GH D V FS + + S D + +W+ + Sbjct: 166 KDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVS-KDGAVFVWEFTKRP 224 Query: 328 ---------IGAEQTPDDAEDGVPELIMVH--AGHRSSVNDFDLNPQIPWLVASAEEENI 376 +Q D + H +++ V +P L+A Sbjct: 225 SDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP-ATRLLAVGFTSGE 283 Query: 377 LQVWK 381 +++ Sbjct: 284 FRLYD 288 >5WLC-LU nrPDB Length = 489 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 50/276 (18%), Positives = 110/276 (39%), Gaps = 53/276 (19%) Query: 158 FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 H+D YA++ + +L +GS D + W + + + + + + ++H Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 218 NFNKDLFG-----TVSEDSLLKINDVRANNTTIDTVKCPQPFN-----------TLAF-- 259 + DL + S+D +K+ + ++ + AF Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQG 184 Query: 260 --SHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSD 317 SH ++ A G + ++L+D+ +K P+ +S D + +L+F+ + ++ S+GSD Sbjct: 185 IDSHRENSTFATGG--AKIHLWDVNRLK-PVSDLSWGADNITSLKFNQNETDILASTGSD 241 Query: 318 NRLMMWDLKQIGAEQ-------------TPDDAEDGV----------------PELIMVH 348 N ++++DL+ Q P +A + V + V Sbjct: 242 NSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVF 301 Query: 349 AGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 H S+V D D +P +V + + ++++K +H Sbjct: 302 KDHVSAVMDVDFSPTGDEIV-TGSYDKSIRIYKTNH 336 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 52/330 (15%), Positives = 106/330 (32%), Gaps = 78/330 (23%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSF----- 168 Y H + + N +AT + G + ++ + + K H L Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRF 123 Query: 169 -----STLVKGRLLSGSDDHTVALWEVG-------------SGGDPTKPVRTWNDLHS-- 208 + +LS SDD TV LW + S + +RT++ + Sbjct: 124 HDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQ 183 Query: 209 ------------------------------------DIINDNKWHNFNKDLFGTVSEDSL 232 D I K++ D+ + D+ Sbjct: 184 GIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNS 243 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 + + D+R N+ T V+ N + ++ + A D Y YD+RN+ L+ Sbjct: 244 IVLYDLRTNSPTQKIVQ-TMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFK 302 Query: 293 GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHR 352 H AV +++FS D +V+ D + ++ + + H Sbjct: 303 DHVSAVMDVDFSPTGDE-IVTGSYDKSIRIYKTNHGHSREI-------------YHTKRM 348 Query: 353 SSVNDFDLNPQIPWLVASAEEENILQVWKC 382 V + +++ S ++ +++W+ Sbjct: 349 QHVFQVKYSMDSKYII-SGSDDGNVRLWRS 377 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 24/192 (12%), Positives = 49/192 (25%), Gaps = 53/192 (27%) Query: 248 VKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTH- 306 +A ++ S N LA D + +++ + +E H V L + Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNM-STREEFVSFKAHYGLVTGLCVTQPR 122 Query: 307 ---------VDGVVVSSGSDNRLMMW-------------DLKQIGAEQTPDDAEDGVPEL 344 ++S D + +W D + E+ DG Sbjct: 123 FHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF 182 Query: 345 ----------IMVHAG---H----------------RSSVNDFDLNPQIPWLVASAEEEN 375 G H ++ N ++AS +N Sbjct: 183 QGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDN 242 Query: 376 ILQVWKCSHSLP 387 + ++ + P Sbjct: 243 SIVLYDLRTNSP 254 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 25/152 (16%), Positives = 50/152 (32%), Gaps = 12/152 (7%) Query: 112 TAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSR---SEGLQSTLKFHKDNGYALSF 168 T K + P + T N + Y S L K H + F Sbjct: 255 TQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLN-VFKDHVSAVMDVDF 313 Query: 169 STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVS 228 S +++GS D ++ +++ G + T H + ++ + + S Sbjct: 314 SPT-GDEIVTGSYDKSIRIYKTNHGH-SREIYHTKRMQHVFQVK----YSMDSKYIISGS 367 Query: 229 EDSLLKINDVRANNTTIDTVKCPQPFNTLAFS 260 +D +++ R+ VK + N L + Sbjct: 368 DDGNVRLW--RSKAWERSNVKTTREKNKLEYD 397 >5I2T-A nrPDB Length = 742 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 52/269 (19%), Positives = 107/269 (39%), Gaps = 18/269 (6%) Query: 95 GEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVA---TINGQGTVFLYSRSEG 151 P + I + + Q +A + GQ V+ + Sbjct: 305 TSGEFRLYDLPDFTL-IQQLSMGQNPVNTVSVN-QTGEWLAFGSSKLGQLLVYEWQSESY 362 Query: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII 211 + + H D+ +L++S R+++ S+D + +W++ SG + T+ H+ + Sbjct: 363 ILKQ-QGHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSGF----CLATFE-EHTSSV 415 Query: 212 NDNKWHNFNKDLFGTVSEDSLLKINDV-RANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 ++ + +F + S D ++ D+ R N T FN LA S ++ A Sbjct: 416 TAVQFAKRGQVMFSS-SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP-SGEVVCAG 473 Query: 271 GMDS-YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG 329 +D+ ++++ ++ + L +SGHE V+ L FS V+ S+ D + +W + Sbjct: 474 SLDNFDIHVWSVQTGQL-LDALSGHEGPVSCLSFSQEN-SVLASASWDKTIRIWSIFGRS 531 Query: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDF 358 + P + V L M G +V+ Sbjct: 532 QQVEPIEVYSDVLALSMRPDGKEVAVSTL 560 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 42/270 (15%), Positives = 91/270 (33%), Gaps = 26/270 (9%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTLVK 173 Y ++ ++ + P ++A G LY L L ++ +S + + Sbjct: 282 YANQAKVKCVTFHPA-TRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGE 340 Query: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 S + ++E S K H D N + + T SED + Sbjct: 341 WLAFGSSKLGQLLVYEWQSESYILKQ-----QGHFDSTNSLAYSP-DGSRVVTASEDGKI 394 Query: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 K+ D+ + + + F+ ++ ++ +D V +DL + +G Sbjct: 395 KVWDITSGFCLATFEEHTSSVTAVQFA-KRGQVMFSSSLDGTVRAWDLIRYRN-FRTFTG 452 Query: 294 -HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHR 352 N L + V S + + +W ++ +L+ +GH Sbjct: 453 TERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQ--------------TGQLLDALSGHE 498 Query: 353 SSVNDFDLNPQIPWLVASAEEENILQVWKC 382 V+ + Q ++ASA + +++W Sbjct: 499 GPVSCLSFS-QENSVLASASWDKTIRIWSI 527 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 93/272 (34%), Gaps = 44/272 (16%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG----LQSTLKFHKDNGYALSFSTL 171 H ++IT + QD + T + + ++S +T H+D FS Sbjct: 169 GHFQDITSLTWS-QDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHD 227 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 + ++ + S D V +WE + +D + ++ +K+ Sbjct: 228 QE-KIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYS-------------- 272 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 + + + F ++ LLA LYDL + + + Sbjct: 273 ----WRITKKHF---FYANQAKVKCVTFHP-ATRLLAVGFTSGEFRLYDLPDFTL-IQQL 323 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 S ++ VN + + + + S +L++++ + I+ GH Sbjct: 324 SMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSES--------------YILKQQGH 369 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 S N +P +V +A E+ ++VW + Sbjct: 370 FDSTNSLAYSPDGSRVV-TASEDGKIKVWDIT 400 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 30/182 (16%), Positives = 57/182 (31%), Gaps = 27/182 (14%) Query: 122 TRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLSGS 180 P + A + ++S G L L H+ LSFS L S S Sbjct: 459 NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASAS 517 Query: 181 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRA 240 D T+ +W + +P+ ++D+ + + + + I ++ Sbjct: 518 WDKTIRIWSIFGRSQQVEPIEVYSDVLALS------MRPDGKEVAVSTLKGQISIFNIED 571 Query: 241 NNTTIDTVKCPQP----FNTLAFSHHSSNL---------------LAAAGMDSYVYLYDL 281 + FN F+ +S + A G ++ + LYD+ Sbjct: 572 AKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDV 631 Query: 282 RN 283 N Sbjct: 632 PN 633 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 36/245 (14%), Positives = 73/245 (29%), Gaps = 32/245 (13%) Query: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN 218 H+ N A+ + L+S +D L + + +N + + K+ Sbjct: 79 HRKNIAAIDLN-KQGTLLISIDEDGRAILVNFKA----RNVLHHFNF--KEKCSAVKFSP 131 Query: 219 FNKDL-FGTVSEDSLLKINDVRANNTTIDTV------KCPQPFNTLAFSHHSSNLLAAAG 271 + + + K DV + V Q +L +S S +L Sbjct: 132 DGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTT-S 190 Query: 272 MDSYVYLY--DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ-- 327 D ++ D +GH D V FS + + S D + +W+ + Sbjct: 191 KDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVS-KDGAVFVWEFTKRP 249 Query: 328 ---------IGAEQTPDDAEDGVPELIMVH--AGHRSSVNDFDLNPQIPWLVASAEEENI 376 +Q D + H +++ V +P L+A Sbjct: 250 SDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP-ATRLLAVGFTSGE 308 Query: 377 LQVWK 381 +++ Sbjct: 309 FRLYD 313 >5Z56-q nrPDB Length = 504 Score = 114 bits (286), Expect = 6e-26, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 102/267 (38%), Gaps = 26/267 (9%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTLKFHKDNGYALSFSTLVKG 174 H +++T + P ++V + + T+ ++S + ++ H+ LS Sbjct: 262 GHTKKVTSVVFHPSQ-DLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT-GD 319 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 LLS SDD A ++ +G TK + + ++H + +FGT + DS +K Sbjct: 320 YLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC---SLTCAQFHP-DGLIFGTGTMDSQIK 375 Query: 235 INDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH 294 I D++ + P ++AFS + LA A DS V L+DLR +K + Sbjct: 376 IWDLKERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVKLWDLRKLKNFKTLQLDN 434 Query: 295 EDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSS 354 V +L F + G+D ++ +Q + I+ H Sbjct: 435 NFEVKSLIFDQSG-TYLALGGTD-------VQIYICKQWTE---------ILHFTEHSGL 477 Query: 355 VNDFDLNPQIPWLVASAEEENILQVWK 381 + +AS + L+ + Sbjct: 478 TTGVAFGHHAKF-IASTGMDRSLKFYS 503 >6QDV-o nrPDB Length = 513 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 54/369 (14%), Positives = 114/369 (30%), Gaps = 78/369 (21%) Query: 67 GEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPR---SNIRITAKYEHEEEITR 123 GEE+ L E+ + PQ + G +S++P + +I H + ++ Sbjct: 169 GEEKTILHVKEMYDYQGRSYLHIPQ-DVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSA 227 Query: 124 ARYMPQDPNIVATINGQGTVFLYSR--SEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSD 181 R P +++ + + + L+ T H + F+T + LS + Sbjct: 228 VRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTA-GTQFLSAAY 286 Query: 182 DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFN--KDLFGTVSEDSLLKINDVR 239 D + LW+ +G ++ + K++ ++LF D + D+R Sbjct: 287 DRYLKLWDTETGQCISRFTN------RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIR 340 Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY------DLRNMKEPLHH--- 290 + + + NT+ F + + D + ++ D + + EP H Sbjct: 341 SGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP 399 Query: 291 ------------------------------------MSGH--EDAVNNLEFSTHVDGVVV 312 GH ++FS V+ Sbjct: 400 AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSP-DMSYVI 458 Query: 313 SSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAE 372 S + +L +WD K +L H +P V + Sbjct: 459 SGDGNGKLNIWDWK--------------TTKLYSRFKAHDKVCIGAVWHPHETSKVITCG 504 Query: 373 EENILQVWK 381 + ++++W Sbjct: 505 WDGLIKLWD 513 Score = 114 bits (284), Expect = 8e-26, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 99/310 (31%), Gaps = 26/310 (8%) Query: 72 YLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDP 131 Y+ ++ P E E + A + + + T + E + R P Sbjct: 133 YVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIP 192 Query: 132 NIVATINGQGT--VFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWE 189 V Y + + H A+ L LLS S D + LWE Sbjct: 193 QDVGVNLRSTMPPEKCYLPKKQI-HVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWE 251 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVK 249 V + +RT+ HS + D ++ + + D LK+ D Sbjct: 252 VYG---ERRCLRTF-IGHSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTN 306 Query: 250 CPQPFNTLAFSHHSS--NLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHV 307 P+ + F+ NL A D + +D+R E + H AVN + F Sbjct: 307 RKVPY-CVKFNPDEDKQNLFVAGMSDKKIVQWDIR-SGEIVQEYDRHLGAVNTIVFV-DE 363 Query: 308 DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWL 367 + VS+ D L +W+ D + + S+ L+P WL Sbjct: 364 NRRFVSTSDDKSLRVWE-------------WDIPVDFKYIAEPSMHSMPAVTLSPNGKWL 410 Query: 368 VASAEEENIL 377 + + IL Sbjct: 411 ACQSMDNQIL 420 >5YZG-W nrPDB Length = 579 Score = 114 bits (284), Expect = 8e-26, Method: Composition-based stats. Identities = 54/369 (14%), Positives = 114/369 (30%), Gaps = 78/369 (21%) Query: 67 GEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPR---SNIRITAKYEHEEEITR 123 GEE+ L E+ + PQ + G +S++P + +I H + ++ Sbjct: 235 GEEKTILHVKEMYDYQGRSYLHIPQ-DVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSA 293 Query: 124 ARYMPQDPNIVATINGQGTVFLYSR--SEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSD 181 R P +++ + + + L+ T H + F+T + LS + Sbjct: 294 VRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTA-GTQFLSAAY 352 Query: 182 DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFN--KDLFGTVSEDSLLKINDVR 239 D + LW+ +G ++ + K++ ++LF D + D+R Sbjct: 353 DRYLKLWDTETGQCISRFTN------RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIR 406 Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY------DLRNMKEPLHH--- 290 + + + NT+ F + + D + ++ D + + EP H Sbjct: 407 SGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP 465 Query: 291 ------------------------------------MSGH--EDAVNNLEFSTHVDGVVV 312 GH ++FS V+ Sbjct: 466 AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSP-DMSYVI 524 Query: 313 SSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAE 372 S + +L +WD K +L H +P V + Sbjct: 525 SGDGNGKLNIWDWK--------------TTKLYSRFKAHDKVCIGAVWHPHETSKVITCG 570 Query: 373 EENILQVWK 381 + ++++W Sbjct: 571 WDGLIKLWD 579 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 99/310 (31%), Gaps = 26/310 (8%) Query: 72 YLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDP 131 Y+ ++ P E E + A + + + T + E + R P Sbjct: 199 YVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIP 258 Query: 132 NIVATINGQGT--VFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWE 189 V Y + + H A+ L LLS S D + LWE Sbjct: 259 QDVGVNLRSTMPPEKCYLPKKQI-HVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWE 317 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVK 249 V + +RT+ HS + D ++ + + D LK+ D Sbjct: 318 VYG---ERRCLRTF-IGHSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTN 372 Query: 250 CPQPFNTLAFSHHSS--NLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHV 307 P+ + F+ NL A D + +D+R E + H AVN + F Sbjct: 373 RKVPY-CVKFNPDEDKQNLFVAGMSDKKIVQWDIR-SGEIVQEYDRHLGAVNTIVFV-DE 429 Query: 308 DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWL 367 + VS+ D L +W+ D + + S+ L+P WL Sbjct: 430 NRRFVSTSDDKSLRVWE-------------WDIPVDFKYIAEPSMHSMPAVTLSPNGKWL 476 Query: 368 VASAEEENIL 377 + + IL Sbjct: 477 ACQSMDNQIL 486 >2HES-X nrPDB Length = 330 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 48/294 (16%), Positives = 109/294 (37%), Gaps = 34/294 (11%) Query: 107 SNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSE--------GLQSTLKF 158 + I + + H++ I + P ++A + TV ++++ E L + ++ Sbjct: 47 TLIDVLDETAHKKAIRSVAWRPHTS-LLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEG 105 Query: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN 218 H++ +++S L + S D +V +WE G+ + + HS + WH Sbjct: 106 HENEVKGVAWS-NDGYYLATCSRDKSVWIWETDESGEEYECISVLQ-EHSQDVKHVIWHP 163 Query: 219 FNKDLFGTVSEDSLLKIN-DVRAN-NTTIDTVKCPQPFNTLAFSHHSS-NLLAAAGMDSY 275 ++ L + S D ++I D + + F L + DS Sbjct: 164 -SEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDST 222 Query: 276 VYLY-------DLRNMKEPLHHMSG-HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 V ++ D + + H+ V N+ + +G++ S G+D L ++ Sbjct: 223 VRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAW--GFNGLIASVGADGVLAVY---- 276 Query: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 + D + + H + +V + L ++A+ ++ I+ W Sbjct: 277 ----EEVDGEWKVFAKRALCHGVYEINVVKW-LELNGKTILATGGDDGIVNFWS 325 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 48/245 (19%), Positives = 88/245 (35%), Gaps = 36/245 (14%) Query: 151 GLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI 210 L +LK +K+ ++ FS +G L +GS D + L V V H Sbjct: 5 NLIKSLKLYKEKIWSFDFS---QGILATGSTDRKIKLVSVKYDDFTLIDVLD-ETAHKKA 60 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTID----------TVKCPQPFNTLAFS 260 I W + L S DS + I A + D +A+S Sbjct: 61 IRSVAWRP-HTSLLAAGSFDSTVSIW---AKEESADRTFEMDLLAIIEGHENEVKGVAWS 116 Query: 261 HHSSNLLAAAGMDSYVYLYDLRNMK---EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSD 317 + LA D V++++ E + + H V ++ + + ++ SS D Sbjct: 117 N-DGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPS-EALLASSSYD 174 Query: 318 NRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNP-QIPWLVASAEEENI 376 + + +W D E + V GH +V D + + + + S +++ Sbjct: 175 DTVRIW------------KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDST 222 Query: 377 LQVWK 381 ++VWK Sbjct: 223 VRVWK 227 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 105/262 (40%), Gaps = 23/262 (8%) Query: 133 IVATINGQGTVFLYSR---SEGLQSTL--KFHKDNGYALSFSTLVKGRLLSGSDDHTVAL 187 I+AT + + L S L L HK ++++ L +GS D TV++ Sbjct: 26 ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHT-SLLAAGSFDSTVSI 84 Query: 188 WEVGSGGDPTKP--VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDV----RAN 241 W D T + + H + + W N + T S D + I + Sbjct: 85 WAKEESADRTFEMDLLAIIEGHENEVKGVAWSN-DGYYLATCSRDKSVWIWETDESGEEY 143 Query: 242 NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY-DLRNMKEPLHHMSGHEDAVNN 300 + Q + + + LLA++ D V ++ D + E + ++GHE V + Sbjct: 144 ECISVLQEHSQDVKHVIWHPSEA-LLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWS 202 Query: 301 LEFSTHVDGVVVSSGSDN-RLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFD 359 +F + SGSD+ + +W K +G ++ DD ++ V E I+ H+ V + Sbjct: 203 SDFDKTEGVFRLCSGSDDSTVRVW--KYMGDDE--DDQQEWVCEAIL-PDVHKRQVYNVA 257 Query: 360 LNPQIPWLVASAEEENILQVWK 381 L+AS + +L V++ Sbjct: 258 WGFNG--LIASVGADGVLAVYE 277 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 35/187 (18%), Positives = 66/187 (35%), Gaps = 16/187 (8%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG---LQSTLKFHKDNGYALS 167 I+ EH +++ + P + ++A+ + TV ++ + + L H+ ++ Sbjct: 146 ISVLQEHSQDVKHVIWHPSEA-LLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSD 204 Query: 168 FSTLVKG-RLLSGSDDHTVALW----EVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKD 222 F RL SGSDD TV +W + D+H + + W Sbjct: 205 FDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAW--GFNG 262 Query: 223 LFGTVSEDSLLKIN---DVRANNTTIDTVKCP-QPFNTLAFSHHSS-NLLAAAGMDSYVY 277 L +V D +L + D + N + + + +LA G D V Sbjct: 263 LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVN 322 Query: 278 LYDLRNM 284 + L Sbjct: 323 FWSLEKA 329 >4LG8-A nrPDB Length = 354 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 61/345 (17%), Positives = 127/345 (36%), Gaps = 33/345 (9%) Query: 45 TPVQELDGGFIKQELIIGTHTSGEEE--NYLKFAEINLPKEILSNEDPQEEAGEEYQSSL 102 T ++ G + +EL+ S + +++ ++P + + P + + Sbjct: 34 TTERKERGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGAD 93 Query: 103 PAPRSNIRITAKY-----EHEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTL 156 + + + H +++T + P ++V + + T+ ++S + + Sbjct: 94 KNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ-DLVFSASPDATIRIWSVPNASCVQVV 152 Query: 157 KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW 216 + H+ LS LLS SDD A ++ +G TK + + ++ Sbjct: 153 RAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS---LTCAQF 208 Query: 217 HNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYV 276 H + +FGT + DS +KI D++ + P ++AFS + LA A DS V Sbjct: 209 HP-DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSV 266 Query: 277 YLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDD 336 L+DLR +K + V +L F + G+D ++ +Q + Sbjct: 267 KLWDLRKLKNFKTLQLDNNFEVKSLIFDQSG-TYLALGGTD-------VQIYICKQWTE- 317 Query: 337 AEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 I+ H + +AS + L+ + Sbjct: 318 --------ILHFTEHSGLTTGVAFGHHAKF-IASTGMDRSLKFYS 353 >5WYK-BB nrPDB Length = 943 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 62/394 (15%), Positives = 138/394 (35%), Gaps = 52/394 (13%) Query: 9 SVDEEYDL----WKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTH 64 ++ Y + W + + V T S T+++ P ++ D + TH Sbjct: 331 TIRSLYKIKSASWTTVSSSKLELVLTTS----SNTIEYYSIPYEKRDPTSPAP---LKTH 383 Query: 65 TSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRA 124 T L+ ++ +S+++ SL + Sbjct: 384 TIE-----LQGQRTDVRSIDISDDNKLLATASN--GSLKIWNIKTHKCIRTFECGYALTC 436 Query: 125 RYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLK-FHKDNGYALSFSTLVKGRLLSGSDD 182 +++P +V G + L+ S L T++ H ++L T RL++GS D Sbjct: 437 KFLPG-GLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDL-TSDGKRLVTGSAD 494 Query: 183 HTVALWEVGSG-----GDPTKPVRTWNDLH------SDIINDNKWHNFNKDLFGTVSEDS 231 TV W+ G K + H +D I + ++ L ++ D+ Sbjct: 495 KTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISL-LDN 553 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 +K+ + + + P ++ S S ++ + D + ++ L + + + Sbjct: 554 TVKVFFLDSMKFYLSLYGHKLPVLSIDISF-DSKMIITSSADKNIKIWGL-DFGDCHKSL 611 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 H+D++ N++F S D + WD ++ E I H Sbjct: 612 FAHQDSIMNVKFLPQSHN-FFSCSKDAVVKYWDGEKF--------------ECIQKLYAH 656 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 +S V + ++V S+ ++ +++W+ + Sbjct: 657 QSEVWALAVATDGGFVV-SSSHDHSIRIWEETED 689 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 81/219 (36%), Gaps = 28/219 (12%) Query: 169 STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI-----INDNKW-HNFNKD 222 + G+L++ S V +W++ +G +K SD + + D Sbjct: 34 NGSGPGQLIT-SALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTD 92 Query: 223 LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLR 282 L D ++K+ D+ + ++ L F + L + DS + ++DL Sbjct: 93 LLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFD-GTGTRLISGSKDSNIIVWDLV 151 Query: 283 NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVP 342 + L+ + H+D++ + + ++S+ D + +WDLK Sbjct: 152 G-EVGLYKLRSHKDSITGF-WC-QGEDWLISTSKDGMIKLWDLK--------------TH 194 Query: 343 ELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 + I H H + L+ + ++ +++WK Sbjct: 195 QCIETHIAHTGECWGLAVKDD---LLITTGTDSQVKIWK 230 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 35/160 (21%), Positives = 66/160 (41%), Gaps = 14/160 (8%) Query: 129 QDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVAL 187 +D +++A G + ++ S+ + HK L F RL+SGS D + + Sbjct: 89 KDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGT-GTRLISGSKDSNIIV 147 Query: 188 WEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDT 247 W++ G +R+ D + W +D + S+D ++K+ D++ + Sbjct: 148 WDLV-GEVGLYKLRSHKDSITGF-----WCQ-GEDWLISTSKDGMIKLWDLKTHQCIETH 200 Query: 248 VKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY--DLRNMK 285 + LA +LL G DS V ++ D+ N K Sbjct: 201 IAHTGECWGLAV---KDDLLITTGTDSQVKIWKLDIENDK 237 Score = 78.3 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 62/177 (35%), Gaps = 12/177 (6%) Query: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 L G D + +W++ S K V + H I ++ + + S+DS + Sbjct: 92 DLLAVGYADGVIKVWDLMS-----KTVLLNFNGHKAAITLLQF-DGTGTRLISGSKDSNI 145 Query: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 + D+ F + L + D + L+DL+ + + Sbjct: 146 IVWDLVGEVGLYKLRSHKDSI--TGFWCQGEDWLISTSKDGMIKLWDLKTH-QCIETHIA 202 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 H L D +++++G+D+++ +W L + E G+ E G Sbjct: 203 HTGECWGLAV---KDDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRG 256 >5OQL-J nrPDB Length = 912 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 60/355 (16%), Positives = 110/355 (30%), Gaps = 73/355 (20%) Query: 71 NYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQD 130 N +++ +ED E Y + HE+ + Sbjct: 394 NSEDIRIVSVKDAQAYSEDNAECRSGSYFG--------HDVALLKGHEDIVMSLDVD-WS 444 Query: 131 PNIVATINGQGTVFLYSRSEG-----LQSTLKFHKDNGYALS------------FSTLVK 173 + +A+ + T L+ + H ++ A++ F + Sbjct: 445 GHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLD 504 Query: 174 ---GRLLSGSDDHTVALWE----VGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGT 226 L+SGS D V + + GG T +R H IN N LF + Sbjct: 505 HPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRL--AHDKDINALDISP-NGKLFAS 561 Query: 227 VSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSH-------------HSSNLLAAAGMD 273 S+D +KI DV + T+ F+ ++ D Sbjct: 562 ASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGD 621 Query: 274 SYVYLYDLRNMKEPLHHMSGHEDAVNNLEF--STHVDGV------VVSSGSDNRLMMWDL 325 + L++L + + GH V + + + D + S+G+D + +WD Sbjct: 622 KTIKLWNL-SDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDA 680 Query: 326 KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 E T D+ ED + A H ++ASA ++ + W Sbjct: 681 NTGETECTLDNHED----RLWTLAVHSK-----------TNILASAGSDSKVTFW 720 Score = 65.2 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 84/283 (29%), Gaps = 52/283 (18%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYS---------RSEGLQSTLKFHKDNGYAL 166 E I+ P +++ + T+ +YS L T K H L Sbjct: 59 GDGEPISTLTITPSGSHLI-VCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVL 117 Query: 167 SFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGT 226 + L +G+ D + +W++ G V S +++ + Sbjct: 118 AVD-RTSTLLATGAADGAIKIWDIIGGY-----VTHTVSGPSVLVSALHFFEIAVTAESQ 171 Query: 227 VSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL-RNMK 285 S K + N A S LA D + ++DL + Sbjct: 172 SSNKKPKK--------------GSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTT 217 Query: 286 EPLHH-----MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDG 340 P++ HE V + +S ++S D + +W D G Sbjct: 218 TPVYADPKRKKEAHESNVQCIAYSPE-QHALLSGSRDKTMTLW--------LWRDGIWQG 268 Query: 341 VPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 P L H + + W+ SA +L++W + Sbjct: 269 TPMLR-----HE-LLESVGFLNEGKWMY-SAGTSGVLRIWDTT 304 >3JRO-A nrPDB Length = 753 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 48/273 (17%), Positives = 92/273 (33%), Gaps = 39/273 (14%) Query: 134 VATINGQGTVFLYSRSEGLQS---TLKFHKDNGYALSFS-TLVKGRLLSGSDDHTVALWE 189 +AT + T+ ++ TL H+ + + ++ L S S D V +W+ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWHNF-NKDLFGTVSEDSLLKINDVRANNTT--ID 246 +G V + +HS +N +W L S D + + + + N TT I Sbjct: 84 EENGRWSQIAV---HAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 Query: 247 TVKCPQPFNTLAFSH------------HSSNLLAAAGMDSYVYLYDLRNMKEPL---HHM 291 N+ +++ S G D+ V ++ + + + Sbjct: 141 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 200 Query: 292 SGHEDAVNNLEFSTHV--DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 GH D V ++ +S V + S D ++W D E G + ++ Sbjct: 201 EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW----------TQDNEQGPWKKTLLKE 250 Query: 350 GHRSSV-NDFDLNPQIPWLVASAEEENILQVWK 381 V + L S +N + +WK Sbjct: 251 EKFPDVLWRASWSLSGNVLALSGG-DNKVTLWK 282 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 79/241 (32%), Gaps = 33/241 (13%) Query: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-H 217 H + + RL + S D T+ ++EV G+ K + T H + W H Sbjct: 8 HNELIHDAVLD-YYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTG-HEGPVWRVDWAH 63 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVK--CPQPFNTLAFSHHS-SNLLAAAGMDS 274 + + S D + I + V N++ ++ H LL A D Sbjct: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 275 YVYLYDLR-NMKEPLHHMSGHEDAVNNLEFST---HVDG---------VVVSSGSDNRLM 321 V + + + N + H VN+ ++ DG V+ G+DN + Sbjct: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 Query: 322 MWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI--PWLVASAEEENILQV 379 +W + GH V D +P + +AS ++ + Sbjct: 184 IWKYNSDAQTYVLE----------STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 Query: 380 W 380 W Sbjct: 234 W 234 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 46/240 (19%), Positives = 83/240 (34%), Gaps = 31/240 (12%) Query: 111 ITAKYEHEEEITRARY-MPQDPNIVATINGQGTVFLYSRSEG---LQSTLKFHKDNGYAL 166 I HE + R + P+ I+A+ + G V ++ G + H + ++ Sbjct: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV 105 Query: 167 SFSTLVKG-RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN------- 218 ++ G LL S D V++ E G + + D H+ +N W Sbjct: 106 QWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII---DAHAIGVNSASWAPATIEEDG 162 Query: 219 -----FNKDLFGTVSEDSLLKIN----DVRANNTTIDTVKCPQPFNTLAFSHH--SSNLL 267 F T D+L+KI D + +A+S + L Sbjct: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 Query: 268 AAAGMDSYVYLYDLRNMKEP-LHHMSGHEDAVNNL---EFSTHVDGVVVSSGSDNRLMMW 323 A+ D ++ N + P + E + L +S V+ SG DN++ +W Sbjct: 223 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWS-LSGNVLALSGGDNKVTLW 281 Score = 40.9 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 30/77 (38%), Gaps = 13/77 (16%) Query: 306 HVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL-NPQI 364 + + + SD + ++++ E +LI GH V D +P+ Sbjct: 19 YYGKRLATCSSDKTIKIFEV------------EGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 365 PWLVASAEEENILQVWK 381 ++AS + + +WK Sbjct: 67 GTILASCSYDGKVLIWK 83 >5XYI-g nrPDB Length = 335 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 38/239 (15%), Positives = 84/239 (35%), Gaps = 26/239 (10%) Query: 147 SRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDL 206 S ++T H ++ L+S S D + +W++ + T Sbjct: 20 SAHFAPRATFVGHNAAIESIEID-NEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIG 78 Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL 266 H+ ++D L + S DS L++ D+ T + + + FS + + Sbjct: 79 HNHFVSDVSLSRDASHLLTS-SWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRI 137 Query: 267 LAAAGMDSYVYLYDLRN-MKEPLHHMSGHEDAVNNLEFSTHVDG----VVVSSGSDNRLM 321 ++ G D+ V ++++ K L S V ++ + D V+ D ++ Sbjct: 138 ISV-GRDNQVKIWNILGENKAELQCSSW----VTSVACAPMADETSPLVIAVGCWDGKVY 192 Query: 322 MWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 +W +++ +LI H D P W++ + + + +W Sbjct: 193 IWSIEKEA-------------KLIKEFKAHDGRCTSVDFTPDGKWVI-TGGSDRKVVMW 237 Score = 81.0 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 37/273 (13%), Positives = 89/273 (32%), Gaps = 16/273 (5%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFS 169 T H ++ + +D + + T + T+ L+ + + HK + ++FS Sbjct: 73 FTRLIGHNHFVSDVS-LSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFS 131 Query: 170 TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 + R++S D+ V +W + +W + + + + Sbjct: 132 PCNR-RIISVGRDNQVKIWNILGENKAELQCSSWV---TSVACAPMADETSPLVIAVGCW 187 Query: 230 DSLLKINDVRANNTTIDTVK-CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPL 288 D + I + I K ++ F+ + G D V ++ N + + Sbjct: 188 DGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTP-DGKWVITGGSDRKVVMWLTENGAKTI 246 Query: 289 HHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVH 348 + V+ + + ++ + +WD IGA+Q D + + Sbjct: 247 SFTA--PSPVHAVAACPTQAWICAATY--EGIAVWD---IGAKQQIDLVQPNFKHEGKRN 299 Query: 349 AGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 AG ++ S + ++ W+ Sbjct: 300 AGRTPDCTCLAWAADGS-VLYSGYNDGSIRAWE 331 >4AEZ-A nrPDB Length = 401 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 55/299 (18%), Positives = 106/299 (35%), Gaps = 34/299 (11%) Query: 104 APRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGL-QSTLKFHKDN 162 A ++ A+ + + ++ D + ++ G G V +Y T+ H+ Sbjct: 120 ADSGSVSALAETDESTYVASVKWS-HDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQAR 178 Query: 163 GYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKD 222 LS++ V L SGS + +V ++ HS + W + Sbjct: 179 VGCLSWNRHV---LSSGSRSGAIHHHDVRIANHQIGTLQ----GHSSEVCGLAW-RSDGL 230 Query: 223 LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG--MDSYVYLYD 280 + D++++I D R++ +A+ SNLLA G MD ++ ++ Sbjct: 231 QLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWN 290 Query: 281 LRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWDLKQIGAEQTPDDAED 339 +G V +L +S H ++ + G DN L +W G + D Sbjct: 291 AATGARVNTVDAG--SQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIP-- 346 Query: 340 GVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW------KCSHSLPIVGGP 392 H + V L+P ++++A + L+ W +PI P Sbjct: 347 ----------AHDTRVLYSALSPDGR-ILSTAASDENLKFWRVYDGDHVKRPIPITKTP 394 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 31/176 (17%), Positives = 60/176 (34%), Gaps = 32/176 (18%) Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVN 299 +D + + N++A A ++ VY+++ + + V Sbjct: 80 TPERVLDAPGIIDDYYLNLLDWSNLNVVAVA-LERNVYVWNADSGSVSALAETDESTYVA 138 Query: 300 NLEFSTHVDGVVVSSGSDNRLM-MWDLKQIGAEQTPDDAEDGVPEL-------------- 344 ++++S DG +S G N L+ ++D++ +T + V L Sbjct: 139 SVKWSH--DGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSG 196 Query: 345 -------------IMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLP 387 I GH S V L AS +N++Q+W S+P Sbjct: 197 AIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQL-ASGGNDNVVQIWDARSSIP 251 >3ODT-A nrPDB Length = 313 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 33/221 (14%), Positives = 85/221 (38%), Gaps = 19/221 (8%) Query: 104 APRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNG 163 A + H+ + + QD +V + + T ++ + L L+ H + Sbjct: 90 ATSGEDPLYTLIGHQGNVCSLSF--QDG-VVISGSWDKTAKVW-KEGSLVYNLQAHNASV 145 Query: 164 YALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDL 223 + + + + L+ S D T+ LW K ++T++ +H+D++ + Sbjct: 146 WDAKVVSFSENKFLTASADKTIKLW------QNDKVIKTFSGIHNDVVRHLAVVDDGH-- 197 Query: 224 FGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN 283 F + S D L+K+ D+ + + + + + G D V ++ N Sbjct: 198 FISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKEN 255 Query: 284 MKEP-LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 + + ++ +++ ++ D ++ SDN + ++ Sbjct: 256 GSLKQVITLP--AISIWSVDCMSNGD--IIVGSSDNLVRIF 292 Score = 99.1 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 53/248 (21%), Positives = 90/248 (36%), Gaps = 36/248 (14%) Query: 140 QGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKP 199 G + E TL H+ N +LSF G ++SGS D T +W Sbjct: 84 NGVPLFATSGEDPLYTLIGHQGNVCSLSF---QDGVVISGSWDKTAKVW------KEGSL 134 Query: 200 VRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVK--CPQPFNTL 257 V H+ + D K +F+++ F T S D +K+ N+ I T L Sbjct: 135 VYNLQ-AHNASVWDAKVVSFSENKFLTASADKTIKLW---QNDKVIKTFSGIHNDVVRHL 190 Query: 258 AFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSD 317 A + D + L D+ L GHE V ++ + D +VS G D Sbjct: 191 AVV--DDGHFISCSNDGLIKLVDMHTGDV-LRTYEGHESFVYCIKLLPNGD--IVSCGED 245 Query: 318 NRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENIL 377 + +W E+G + ++ S+ D +V S+ +N++ Sbjct: 246 RTVRIW------------SKENGSLKQVITLP--AISIWSVDCMSNGDIIVGSS--DNLV 289 Query: 378 QVWKCSHS 385 +++ S Sbjct: 290 RIFSQEKS 297 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 36/211 (17%), Positives = 72/211 (34%), Gaps = 27/211 (12%) Query: 193 GGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQ 252 G DP + L + + +VS D +++ Sbjct: 1 GIDPFTGYQLSATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQG 60 Query: 253 PFNTLAFSHHSSNLLAAAGMDSYVY---LYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG 309 N++ + LL G D+ + L+ + ++PL+ + GH+ V +L F DG Sbjct: 61 FLNSVCYD-SEKELLLFGGKDTMINGVPLF-ATSGEDPLYTLIGHQGNVCSLSF---QDG 115 Query: 310 VVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVA 369 VV+S D +W L+ H +SV D + Sbjct: 116 VVISGSWDKTAKVW----------------KEGSLVYNLQAHNASVWDAKVVSFSENKFL 159 Query: 370 SAEEENILQVWKCSHSLPIVGGPPKVNKDII 400 +A + +++W+ + G ++ D++ Sbjct: 160 TASADKTIKLWQNDKVIKTFSG---IHNDVV 187 >2AQ5-A nrPDB Length = 402 Score = 106 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 26/149 (17%), Positives = 61/149 (40%), Gaps = 19/149 (12%) Query: 237 DVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN------MKEPLHH 290 R + P +A+ H+ N++A+ D V ++++ + ++EP+ Sbjct: 67 TGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVIT 126 Query: 291 MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 + GH V + + V++S+G DN +++WD+ G L + Sbjct: 127 LEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDV------------GTGAAVLTLGPDV 174 Query: 351 HRSSVNDFDLNPQIPWLVASAEEENILQV 379 H ++ D + L+ ++ + ++V Sbjct: 175 HPDTIYSVDWSRDGA-LICTSCRDKRVRV 202 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 40/236 (16%), Positives = 86/236 (36%), Gaps = 17/236 (7%) Query: 103 PAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG--------LQS 154 R + + H + + P + N++A+ + TV ++ +G Sbjct: 66 KTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVI 125 Query: 155 TLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDN 214 TL+ H +++ + LLS D+ + +W+VG+G D+H D I Sbjct: 126 TLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLG---PDVHPDTIYSV 182 Query: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM-- 272 W + L T D +++ + R + + + + S + G Sbjct: 183 DWS-RDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSR 241 Query: 273 --DSYVYLYDLRNMKEPLHHMS-GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 + V L+D ++++EPL V F + V + D+ + +++ Sbjct: 242 MSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEI 297 Score = 78.7 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 36/167 (21%), Positives = 63/167 (37%), Gaps = 17/167 (10%) Query: 237 DVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMK---EPLHHMSG 293 DVR + TT D+ C A + L+ A + L + + + G Sbjct: 27 DVRVSQTTWDSGFC-------AVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCG 79 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 H V ++ + H D V+ S D +M+W++ G E ++ GH Sbjct: 80 HTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLR-------EPVITLEGHTK 132 Query: 354 SVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDII 400 V +P ++ SA +N++ VW ++ P V+ D I Sbjct: 133 RVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTI 179 >5G04-R nrPDB Length = 499 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 68/357 (19%), Positives = 124/357 (34%), Gaps = 63/357 (17%) Query: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 +N LK L ++ + + +P+ I + ++ + + Sbjct: 145 QNRLKV---------LYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSG 195 Query: 130 DPNIVATINGQGTVFLYSRSEGLQSTL---KFHKDNGYALSFSTLVKGRLLSGSDDHTVA 186 + ++A +V+L+S S G L + + ++++ L G+ V Sbjct: 196 N--VLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAW-IKEGNYLAVGTSSAEVQ 251 Query: 187 LWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNT-TI 245 LW+V K +R HS + W N + + S + +DVR Sbjct: 252 LWDVQ----QQKRLRNM-TSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVA 303 Query: 246 DTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL---RNMKEPLHHMSGHEDAVNNLE 302 Q L ++ + LA+ G D+ V ++ PL + H+ AV + Sbjct: 304 TLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 Query: 303 FSTHVDGVVVSSG--SDNRLMMWDLKQIGAEQTPDDAEDGVP---------ELIMVHA-- 349 + V+ + G SD + +W++ GA + DA V ELI H Sbjct: 363 WCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFA 421 Query: 350 -------------------GHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLP 387 GH S V ++P VASA + L++W+C P Sbjct: 422 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFELDP 477 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 90/239 (37%), Gaps = 13/239 (5%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSR--SEGLQSTLKFHKDNGYALSFSTLVKG 174 H + + + I+++ + G + + +E +TL H L ++ Sbjct: 267 HSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGR 322 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVS--EDSL 232 L SG +D+ V +W G P++T+ H + W + ++ T D Sbjct: 323 HLASGGNDNLVNVWPSAPGEGGWVPLQTF-TQHQGAVKAVAWCPWQSNVLATGGGTSDRH 381 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM-DSYVYLYDLRNMKEPLHHM 291 ++I +V + Q ++ +S H L++ G + + ++ + + Sbjct: 382 IRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPT-MAKVAEL 439 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 GH V +L S V S+ +D L +W ++ + + + + ++H G Sbjct: 440 KGHTSRVLSLTMSP-DGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 497 >4GGA-A nrPDB Length = 420 Score = 104 bits (260), Expect = 6e-23, Method: Composition-based stats. Identities = 68/357 (19%), Positives = 124/357 (34%), Gaps = 63/357 (17%) Query: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 +N LK L ++ + + +P+ I + ++ + + Sbjct: 66 QNRLKV---------LYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSG 116 Query: 130 DPNIVATINGQGTVFLYSRSEGLQSTL---KFHKDNGYALSFSTLVKGRLLSGSDDHTVA 186 + ++A +V+L+S S G L + + ++++ L G+ V Sbjct: 117 N--VLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAW-IKEGNYLAVGTSSAEVQ 172 Query: 187 LWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNT-TI 245 LW+V K +R HS + W N + + S + +DVR Sbjct: 173 LWDVQ----QQKRLRNM-TSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVA 224 Query: 246 DTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL---RNMKEPLHHMSGHEDAVNNLE 302 Q L ++ + LA+ G D+ V ++ PL + H+ AV + Sbjct: 225 TLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 283 Query: 303 FSTHVDGVVVSSG--SDNRLMMWDLKQIGAEQTPDDAEDGVP---------ELIMVHA-- 349 + V+ + G SD + +W++ GA + DA V ELI H Sbjct: 284 WCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFA 342 Query: 350 -------------------GHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLP 387 GH S V ++P VASA + L++W+C P Sbjct: 343 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFELDP 398 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 90/239 (37%), Gaps = 13/239 (5%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSR--SEGLQSTLKFHKDNGYALSFSTLVKG 174 H + + + I+++ + G + + +E +TL H L ++ Sbjct: 188 HSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGR 243 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVS--EDSL 232 L SG +D+ V +W G P++T+ H + W + ++ T D Sbjct: 244 HLASGGNDNLVNVWPSAPGEGGWVPLQTF-TQHQGAVKAVAWCPWQSNVLATGGGTSDRH 302 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM-DSYVYLYDLRNMKEPLHHM 291 ++I +V + Q ++ +S H L++ G + + ++ + + Sbjct: 303 IRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPT-MAKVAEL 360 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 GH V +L S V S+ +D L +W ++ + + + + ++H G Sbjct: 361 KGHTSRVLSLTMSP-DGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 418 >5FVM-C nrPDB Length = 303 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 41/254 (16%), Positives = 86/254 (33%), Gaps = 33/254 (12%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTLVKG 174 H+ +T + Q+ + + + GT+ ++ RS +Q K H ++ +G Sbjct: 73 GHKGNVTSIAFQ-QENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEVAIHPN-QG 129 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWND-LHSDIINDNKWHNFNKDLFGTVSEDSLL 233 L+S D + +W++G + N L S + + + + Sbjct: 130 ELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASD------GSMLVAGNNKGNC 183 Query: 234 KIN------DVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEP 287 + D + + S N LA D ++++ + + Sbjct: 184 YVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN-LATCSADHTARVWNIEDNYQL 242 Query: 288 LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMV 347 + GH+ V + FS +V++ SD+ + +WDL E++ Sbjct: 243 ETTLDGHQRWVWDCAFS-ADSAYLVTACSDHYVRLWDLS--------------TSEIVRQ 287 Query: 348 HAGHRSSVNDFDLN 361 + GH LN Sbjct: 288 YGGHHKGAVCVALN 301 Score = 99.1 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 51/303 (16%), Positives = 107/303 (35%), Gaps = 74/303 (24%) Query: 133 IVATINGQGTVFLY--------------------------------------------SR 148 I+A+ T+ + S Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSN 63 Query: 149 SEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHS 208 + S+ + HK N +++F ++S S+D T+ +W+V S N H+ Sbjct: 64 NPNPVSSFEGHKGNVTSIAFQ-QENRWMVSSSEDGTIKVWDVRSPSVQR------NYKHN 116 Query: 209 DIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTID-TVKCPQPFNTLAFSHHSSNLL 267 +N+ H +L + +D ++I D+ N T T + P +L+ + ++L Sbjct: 117 APVNEVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVA-SDGSML 174 Query: 268 AAAGMDSYVYLYDLR-----NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 A Y++ + + EP+ H + + S V + + +D+ + Sbjct: 175 VAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN-LATCSADHTARV 233 Query: 323 WDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 W+++ +T D GH+ V D + +LV +A ++ +++W Sbjct: 234 WNIEDNYQLETTLD-------------GHQRWVWDCAFSADSAYLV-TACSDHYVRLWDL 279 Query: 383 SHS 385 S S Sbjct: 280 STS 282 Score = 77.5 bits (189), Expect = 9e-15, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 65/194 (33%), Gaps = 9/194 (4%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKG 174 Y+H + P ++ + + G + ++ E + +DN S S G Sbjct: 113 YKHNAPVNEVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDG 171 Query: 175 RLLSGSDDH-TVALWEVGSGGDPTK--PVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 +L ++ +W + D + PV + I + + T S D Sbjct: 172 SMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVL--LSADVKNLATCSADH 229 Query: 232 LLKINDVR-ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHH 290 ++ ++ + AFS S+ L+ A D YV L+DL E + Sbjct: 230 TARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACS-DHYVRLWDLSTS-EIVRQ 287 Query: 291 MSGHEDAVNNLEFS 304 GH + + Sbjct: 288 YGGHHKGAVCVALN 301 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 48/119 (40%), Gaps = 16/119 (13%) Query: 263 SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 S +LA+AG D + ++ + + VN LE T + ++G + + + Sbjct: 1 MSVILASAGYDHTIRFWEALT-GVCSRTIQHADSQVNRLEI-TSDKKYLAAAGHLH-VRL 57 Query: 323 WDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 +D++ P + GH+ +V + W+V S+ E+ ++VW Sbjct: 58 YDIRSNN------------PNPVSSFEGHKGNVTSIAFQQENRWMV-SSSEDGTIKVWD 103 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 6/57 (10%), Positives = 17/57 (29%), Gaps = 2/57 (3%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTL 171 H+ + + D + T V L+ + + H ++ + + Sbjct: 248 GHQRWVWDCAFS-ADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVALNDV 303 >5LCW-Q nrPDB Length = 374 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 68/357 (19%), Positives = 124/357 (34%), Gaps = 63/357 (17%) Query: 70 ENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ 129 +N LK L ++ + + +P+ I + ++ + + Sbjct: 20 QNRLKV---------LYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSG 70 Query: 130 DPNIVATINGQGTVFLYSRSEGLQSTL---KFHKDNGYALSFSTLVKGRLLSGSDDHTVA 186 + ++A +V+L+S S G L + + ++++ L G+ V Sbjct: 71 N--VLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAW-IKEGNYLAVGTSSAEVQ 126 Query: 187 LWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNT-TI 245 LW+V K +R HS + W N + + S + +DVR Sbjct: 127 LWDVQ----QQKRLRNM-TSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVA 178 Query: 246 DTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL---RNMKEPLHHMSGHEDAVNNLE 302 Q L ++ + LA+ G D+ V ++ PL + H+ AV + Sbjct: 179 TLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 237 Query: 303 FSTHVDGVVVSSG--SDNRLMMWDLKQIGAEQTPDDAEDGVP---------ELIMVHA-- 349 + V+ + G SD + +W++ GA + DA V ELI H Sbjct: 238 WCPWQSNVLATGGGTSDRHIRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGFA 296 Query: 350 -------------------GHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLP 387 GH S V ++P VASA + L++W+C P Sbjct: 297 QNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA-TVASAAADETLRLWRCFELDP 352 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 90/239 (37%), Gaps = 13/239 (5%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSR--SEGLQSTLKFHKDNGYALSFSTLVKG 174 H + + + I+++ + G + + +E +TL H L ++ Sbjct: 142 HSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGR 197 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVS--EDSL 232 L SG +D+ V +W G P++T+ H + W + ++ T D Sbjct: 198 HLASGGNDNLVNVWPSAPGEGGWVPLQTF-TQHQGAVKAVAWCPWQSNVLATGGGTSDRH 256 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM-DSYVYLYDLRNMKEPLHHM 291 ++I +V + Q ++ +S H L++ G + + ++ + + Sbjct: 257 IRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPT-MAKVAEL 314 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 GH V +L S V S+ +D L +W ++ + + + + ++H G Sbjct: 315 KGHTSRVLSLTMSP-DGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQG 372 >3BG0-A nrPDB Length = 316 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 48/246 (19%), Positives = 86/246 (34%), Gaps = 60/246 (24%) Query: 196 PTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTI--DTVKCPQP 253 + T + H D+I+D + ++ T S D +KI DVR + D P Sbjct: 1 MVSVINTVDTSHEDMIHDAQ-MDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGP 59 Query: 254 FNTLAF-SHHSSNLLAAAGMDSYVYLYDLRNM-KEPLHHMSGHEDAVNNLEFSTHVDGVV 311 +A+ N+LA+ D V ++ N E H +GH+ +VN++ ++ H G++ Sbjct: 60 VWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLI 119 Query: 312 VSSGSDNRLM---------MWDLKQIGAEQTP---------------------------- 334 ++ GS + + W++K+I T Sbjct: 120 LACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYI 179 Query: 335 ---------------DDAEDGVPELIMVHAGHRSSVNDFDLNPQIPW---LVASAEEENI 376 + EDG + H V D P I +AS ++ Sbjct: 180 KRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 Query: 377 LQVWKC 382 + +W C Sbjct: 240 VFIWTC 245 Score = 99.1 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 40/247 (16%), Positives = 86/247 (34%), Gaps = 33/247 (13%) Query: 107 SNIRITAKYEHEEEITRARY-MPQDPNIVATINGQGTVFLYSRSEGL---QSTLKFHKDN 162 I I HE + + + P NI+A+ + V ++ G H + Sbjct: 46 GQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSS 105 Query: 163 GYALSFSTLVKGR-LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH---- 217 ++ ++ G L GS D ++L + G+ V+ N+ H+ N W Sbjct: 106 VNSVCWAPHDYGLILACGSSDGAISL--LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVV 163 Query: 218 ------------NFNKDLFGTVSEDSLLKINDVRAN---NTTIDTVKCPQPFNTLAFSHH 262 F + D+L+K+ + +A++ Sbjct: 164 PGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPS 223 Query: 263 ---SSNLLAAAGMDSYVYLY---DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGS 316 ++ +A+ D V+++ D + + D V ++ +S + ++ SG Sbjct: 224 IGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITAN-ILAVSGG 282 Query: 317 DNRLMMW 323 DN++ +W Sbjct: 283 DNKVTLW 289 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 45/284 (15%), Positives = 95/284 (33%), Gaps = 53/284 (18%) Query: 134 VATINGQGTVFLYSRSEG---LQSTLKFHKDNGYALSFS-TLVKGRLLSGSDDHTVALWE 189 +AT + +V ++ G L + L+ H+ + ++++ + L S S D V +W Sbjct: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWR 87 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWHNFN-KDLFGTVSEDSLLKIND-VRANNTTIDT 247 +G + H +N W + + S D + + + Sbjct: 88 EENGTWEKS---HEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144 Query: 248 VKCPQPFNTLAFS------------------HHSSNLLAAAGMDSYVYLY--DLRNMKEP 287 + A S + A+ G D+ + L+ + + Sbjct: 145 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 204 Query: 288 LHHMSGHEDAVNNLEFSTHVD---GVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 + H D V ++ ++ + + S D R+ +W T DDA Sbjct: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW---------TCDDASSNTWSP 255 Query: 345 IMVHAGHRSSVNDFDLNPQIPW-----LVASAEEENILQVWKCS 383 ++H ND + + W ++A + +N + +WK S Sbjct: 256 KLLH-----KFNDVVWH--VSWSITANILAVSGGDNKVTLWKES 292 >5FA5-B nrPDB Length = 367 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 36/210 (17%), Positives = 83/210 (39%), Gaps = 7/210 (3%) Query: 114 KYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGL-QSTLKFHKDNGYALSFSTLV 172 KYEH++ ++ + V + + + ++ ++ + S+ + H ++ S Sbjct: 146 KYEHDDIVSTVSVLSSGTQAV-SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHK 204 Query: 173 KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSL 232 LS S+D+ + LW+ ++ + WH ++F E+ Sbjct: 205 DSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP---TSLAWHPQQSEVFVFGDENGT 261 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 + + D ++ + + + Q L FS HS LA+ D + + D + L Sbjct: 262 VSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD--SSLSELFRSQ 319 Query: 293 GHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 H D V + +S ++ + G D++++ Sbjct: 320 AHRDFVRDATWSPLNHSLLTTVGWDHQVVH 349 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 43/256 (16%), Positives = 83/256 (32%), Gaps = 24/256 (9%) Query: 134 VATINGQGTVFLYS-----RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALW 188 ++ G+++L+ +EG S + L++ +L SD V LW Sbjct: 74 LSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERG--ILVASDSGAVELW 131 Query: 189 EVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTV 248 E+ + + H DI++ + + S+D +K+ D+ Sbjct: 132 EL-DENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV-SGSKDICIKVWDLAQQVVLSSYR 189 Query: 249 KCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAV-NNLEFSTHV 307 +A S H ++ + D+ + L+D R K + +L + Sbjct: 190 AHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQ 249 Query: 308 DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWL 367 V V + + + D K ++ A H V +P Sbjct: 250 SEVFVFGDENGTVSLVDTK--------------STSCVLSSAVHSQCVTGLVFSPHSVPF 295 Query: 368 VASAEEENILQVWKCS 383 +AS E+ L V S Sbjct: 296 LASLSEDCSLAVLDSS 311 >3JRP-A nrPDB Length = 379 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 93/272 (34%), Gaps = 37/272 (13%) Query: 134 VATINGQGTVFLYSRSEGLQS---TLKFHKDNGYALSFS-TLVKGRLLSGSDDHTVALWE 189 +AT + T+ ++ TL H+ + + ++ L S S D V +W+ Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 85 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWHNF-NKDLFGTVSEDSLLKINDVRANNTT--ID 246 +G V + +HS +N +W L S D + + + + N TT I Sbjct: 86 EENGRWSQIAV---HAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 142 Query: 247 TVKCPQPFNTLAFSH------------HSSNLLAAAGMDSYVYLYDLRNMKEPL---HHM 291 N+ +++ S G D+ V ++ + + + Sbjct: 143 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 202 Query: 292 SGHEDAVNNLEFSTHV--DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 GH D V ++ +S V + S D ++W D E G + ++ Sbjct: 203 EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW----------TQDNEQGPWKKTLLKE 252 Query: 350 GHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 V ++A + +N + +WK Sbjct: 253 EKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 284 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 79/241 (32%), Gaps = 33/241 (13%) Query: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-H 217 H + + RL + S D T+ ++EV G+ K + T H + W H Sbjct: 10 HNELIHDAVLD-YYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTG-HEGPVWRVDWAH 65 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVK--CPQPFNTLAFSHHS-SNLLAAAGMDS 274 + + S D + I + V N++ ++ H LL A D Sbjct: 66 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 125 Query: 275 YVYLYDLR-NMKEPLHHMSGHEDAVNNLEFST---HVDG---------VVVSSGSDNRLM 321 V + + + N + H VN+ ++ DG V+ G+DN + Sbjct: 126 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 185 Query: 322 MWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI--PWLVASAEEENILQV 379 +W + GH V D +P + +AS ++ + Sbjct: 186 IWKYNSDAQTYVLE----------STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 235 Query: 380 W 380 W Sbjct: 236 W 236 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 46/240 (19%), Positives = 82/240 (34%), Gaps = 31/240 (12%) Query: 111 ITAKYEHEEEITRARY-MPQDPNIVATINGQGTVFLYSRSEG---LQSTLKFHKDNGYAL 166 I HE + R + P+ I+A+ + G V ++ G + H + ++ Sbjct: 48 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV 107 Query: 167 SFSTLVKG-RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN------- 218 ++ G LL S D V++ E G + + D H+ +N W Sbjct: 108 QWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII---DAHAIGVNSASWAPATIEEDG 164 Query: 219 -----FNKDLFGTVSEDSLLKIN----DVRANNTTIDTVKCPQPFNTLAFSHH--SSNLL 267 F T D+L+KI D + +A+S + L Sbjct: 165 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 224 Query: 268 AAAGMDSYVYLYDLRNM----KEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 A+ D ++ N K+ L D + +S V+ SG DN++ +W Sbjct: 225 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWS-LSGNVLALSGGDNKVTLW 283 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 30/77 (38%), Gaps = 13/77 (16%) Query: 306 HVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL-NPQI 364 + + + SD + ++++ E +LI GH V D +P+ Sbjct: 21 YYGKRLATCSSDKTIKIFEV------------EGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 365 PWLVASAEEENILQVWK 381 ++AS + + +WK Sbjct: 69 GTILASCSYDGKVLIWK 85 >4J0W-A nrPDB Length = 343 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 84/242 (34%), Gaps = 28/242 (11%) Query: 153 QSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWND------L 206 L+ H+ + L + + S + D ++ W V SG R Sbjct: 7 IRVLRGHQLSITCLVVTP-DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG 65 Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL 266 HS + + + L+ I + ++ + LAF ++ Sbjct: 66 HSSHVLCMAIS-SDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR-RGTHQ 123 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 L + D V ++++ + + GH+DAV L+ + + V + G D + +W + Sbjct: 124 LYSTSHDRSVKVWNV-AENSYVETLFGHQDAVAALDALSR-ECCVTAGGRDGTVRVWKI- 180 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 E +V GH+ S++ L +V S ++ + +W S Sbjct: 181 --------------PEESQLVFYGHQGSIDCIHLI-NEEHMV-SGADDGSVALWGLSKKR 224 Query: 387 PI 388 P+ Sbjct: 225 PL 226 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 30/195 (15%), Positives = 65/195 (33%), Gaps = 30/195 (15%) Query: 206 LHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANN-----------TTIDTVKCPQPF 254 H I + +F + ++D + V + Sbjct: 12 GHQLSITCLVVTPDDSAIF-SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHV 70 Query: 255 NTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSS 314 +A S LA+ + +++ ++ + L+ +GH DAV+ L F + S+ Sbjct: 71 LCMAIS-SDGKYLASGDRSKLILIWEAQSCQH-LYTFTGHRDAVSGLAF-RRGTHQLYST 127 Query: 315 GSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEE 374 D + +W++ + +T GH+ +V D + V + + Sbjct: 128 SHDRSVKVWNVAENSYVETL--------------FGHQDAVAALDALSRE-CCVTAGGRD 172 Query: 375 NILQVWKCSHSLPIV 389 ++VWK +V Sbjct: 173 GTVRVWKIPEESQLV 187 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 34/188 (18%), Positives = 72/188 (38%), Gaps = 14/188 (7%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFST 170 + + H++ + + ++ + A GTV ++ E Q H+ + + Sbjct: 144 VETLFGHQDAVAALDALSRECCVTA-GGRDGTVRVWKIPEESQLVFYGHQGSIDCIHL-- 200 Query: 171 LVKGRLLSGSDDHTVALWEVG-----SGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFG 225 + + ++SG+DD +VALW + + +R L + N DL Sbjct: 201 INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVA 260 Query: 226 TVSEDSLLKINDVRANNTTIDTVKCPQP----FNTLAFSHHSSNLLAAAGMDSYV-YLYD 280 T S S +++ +D + C P N+L FS L+A G + + + Sbjct: 261 TGSHSSCVRLWQCGEGFRQLDLL-CDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRWWR 319 Query: 281 LRNMKEPL 288 ++ + + Sbjct: 320 IKEARNSV 327 >6ELZ-p nrPDB Length = 460 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 44/312 (14%), Positives = 95/312 (30%), Gaps = 75/312 (24%) Query: 134 VATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSG 193 + + + G V + S +Q H A+ + + RL+S +D T+ LW+ + Sbjct: 118 IISGSYDGIVRTWDLSGNVQKQYSGHSGPIRAVKY--ISNTRLVSAGNDRTLRLWKTKND 175 Query: 194 GDPTK------------------PVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 + H + + ++ + S D+ + Sbjct: 176 DLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVSDNSR--ILSASYDNSIGF 233 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM--------DSYVYLYDLRNMKEP 287 +T + P + ++ +N ++ A D + + P Sbjct: 234 W-----STIYKEMTVVDPLEDI---NNPNNKISTAARKRRKLTMKDGTIR------RRAP 279 Query: 288 LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAED-------- 339 L + H V + F + + V S D+ + WDL T + Sbjct: 280 LSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLS 339 Query: 340 --------GVPELIMVH---------------AGHRSSVNDFDLNPQIPWLVASAEEENI 376 I +H GH++ V+ D P+ +++ S + Sbjct: 340 TLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGT 399 Query: 377 LQVWKCSHSLPI 388 ++VW + P+ Sbjct: 400 VKVWDVRSTSPM 411 Score = 97.9 bits (242), Expect = 7e-21, Method: Composition-based stats. Identities = 50/327 (15%), Positives = 104/327 (31%), Gaps = 74/327 (22%) Query: 113 AKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG--------------------- 151 H I +Y+ + + T+ L+ Sbjct: 139 QYSGHSGPIRAVKYISNTR--LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIE 196 Query: 152 ---LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWE------------------- 189 + L+ HK +S R+LS S D+++ W Sbjct: 197 DGKTLAILEGHKAPV--VSIDVSDNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPN 254 Query: 190 --------------VGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 + G + + + H+ + + + + + +VS+D +K Sbjct: 255 NKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKT 314 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLR---NMKEPLHHMS 292 D+ IDT ++A + NLLA ++ L+D R + K + Sbjct: 315 WDLVTARC-IDTRTTSYSLLSIA-QLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLI 372 Query: 293 GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHR 352 GH++ V++L+ + ++ S D + +WD++ T E V G Sbjct: 373 GHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTI------TREDKSVQKGVN 426 Query: 353 SSVNDFDLNPQIPWLVASAEEENILQV 379 V ++ + SA ++ +Q+ Sbjct: 427 DKVFAVKWAEKVG--IISAGQDKKIQI 451 >3JB9-g nrPDB Length = 558 Score = 101 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 59/316 (18%), Positives = 97/316 (30%), Gaps = 71/316 (22%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSR--SEGLQSTLKFHKDNGYALSFSTLVK 173 H + I+ R+ P +++ + + + ++ L T + H LSFS Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFS--QD 321 Query: 174 GR-LLSGSDDHTVALWEVGSGG------------------DPTKPVRTWND--------- 205 GR LS S D T+ LW+ G DP KP Sbjct: 322 GRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQF 381 Query: 206 ------------LHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRAN---NTTIDTVKC 250 H IN + N F T S+DS ++ + D Sbjct: 382 DIRSPDIVQAYDHHLGGINSITFL-ENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMH 440 Query: 251 PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL----RNMKEPLHHMSGHEDAVNNLEFSTH 306 P +A + + +A +D+ +Y+Y R K+ + + FS Sbjct: 441 SMP--RVALRPNGKS-IACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSP- 496 Query: 307 VDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPW 366 V S S WD K +L+ H V +PQ Sbjct: 497 DGRFVFSGDSSGNACFWDWK--------------TCKLMAKLPAHSGPVQSMAFHPQETS 542 Query: 367 LVASAE-EENILQVWK 381 VA++ + ++ W Sbjct: 543 KVATSSIVDGSIKYWD 558 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 43/215 (20%), Positives = 78/215 (36%), Gaps = 13/215 (6%) Query: 149 SEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHS 208 + T K H L F + LLSGS D+ + +WEV +RT+ H+ Sbjct: 255 PKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEV---YHDRSLLRTFQG-HA 310 Query: 209 DIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAF--SHHSSNL 266 I D + + T S D +K+ D ++ + N + F N Sbjct: 311 RPIRDLSFSQDGRSFLST-SFDKTIKLWDTELGKC-LNCFNSDRLTNCVKFQVDPDKPNE 368 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL- 325 A D + +D+R+ + H +N++ F V++ D+ + W+ Sbjct: 369 FLAGTADKRILQFDIRSPDI-VQAYDHHLGGINSITFL-ENGKRFVTTSDDSSMRFWEYG 426 Query: 326 KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL 360 + + D A +P + + G S+ L Sbjct: 427 TPVPIKFVADIAMHSMPRVALRPNG--KSIACQSL 459 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 24/178 (13%), Positives = 57/178 (32%), Gaps = 32/178 (17%) Query: 241 NNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNN 300 + + L F S +LL + MD+ + ++++ + + L GH + + Sbjct: 256 KKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRD 315 Query: 301 LEFSTHVDGVVVSSGSDNRLMMWD----------------------LKQIGAEQTPDDAE 338 L FS +S+ D + +WD + + Sbjct: 316 LSFS-QDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTA 374 Query: 339 DG--------VPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPI 388 D P+++ + H +N + +++ ++ W+ +PI Sbjct: 375 DKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKR-FVTTSDDSSMRFWEYGTPVPI 431 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 11/62 (17%), Positives = 24/62 (38%) Query: 324 DLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 D+ +E+ + + I GH ++ P L+ S +N +++W+ Sbjct: 238 DVGINLSEEPGEQTCYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVY 297 Query: 384 HS 385 H Sbjct: 298 HD 299 >4N14-A nrPDB Length = 314 Score = 101 bits (250), Expect = 8e-22, Method: Composition-based stats. Identities = 64/328 (19%), Positives = 115/328 (35%), Gaps = 54/328 (16%) Query: 99 QSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTL-- 156 +P+ I + ++ + + + ++A +V+L+S S G L Sbjct: 2 CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGN--VLAVAL-DNSVYLWSASSGDILQLLQ 58 Query: 157 -KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNK 215 + + ++++ L G+ V LW+V K +R HS + Sbjct: 59 MEQPGEYISSVAW-IKEGNYLAVGTSSAEVQLWDVQ----QQKRLRNM-TSHSARVGSLS 112 Query: 216 WHNFNKDLFGTVSEDSLLKINDVRANNT-TIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS 274 W N + + S + +DVR Q L ++ + LA+ G D+ Sbjct: 113 W---NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDN 168 Query: 275 YVYLYDL---RNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSG--SDNRLMMWDLKQIG 329 V ++ PL + H+ AV + + V+ + G SD + +W++ G Sbjct: 169 LVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS-G 227 Query: 330 AEQTPDDAEDGVP---------ELIMVHA---------------------GHRSSVNDFD 359 A + DA V ELI H GH S V Sbjct: 228 ACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 287 Query: 360 LNPQIPWLVASAEEENILQVWKCSHSLP 387 ++P VASA + L++W+C P Sbjct: 288 MSPDGA-TVASAAADETLRLWRCFELDP 314 >4L9O-A nrPDB Length = 349 Score = 101 bits (250), Expect = 9e-22, Method: Composition-based stats. Identities = 40/233 (17%), Positives = 78/233 (33%), Gaps = 25/233 (10%) Query: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-H 217 H D + RL + S D T+ ++E+ + + H + W H Sbjct: 68 HDDLIHDAVLD-YYGRRLATCSSDKTIKIFEIDG---ENQRLVETLIGHEGPVWQVAWAH 123 Query: 218 NFNKDLFGTVSEDSLLKIN--DVRANNTTIDTVKCPQPFNTLAFSHHS-SNLLAAAGMDS 274 + + S D + I D N + N+++++ H +L A D Sbjct: 124 PKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDG 183 Query: 275 YVYLYDLRNMK-EPLHHMSGHEDAVNNLEFSTH----VDGVVVSSGSDNRLMMWDLKQIG 329 + + + ++ + GH VN ++ VS G DN + +W Sbjct: 184 KISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAA 243 Query: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQ--IPWLVASAEEENILQVW 380 ++A GH V D +P +A+A ++ + +W Sbjct: 244 KTFIEEEA----------FQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIW 286 Score = 98.7 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 89/231 (38%), Gaps = 21/231 (9%) Query: 111 ITAKYEHEEEITRARY-MPQDPNIVATINGQGTVFLYSRSEGL---QSTLKFHKDNGYAL 166 + HE + + + P+ I+A+ + G V ++ G+ + H+ + ++ Sbjct: 106 VETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSV 165 Query: 167 SFSTLVKG-RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNF----NK 221 S++ G LL S D +++ E GG V H+ +N W N Sbjct: 166 SWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQ---GHAIGVNAASWAPISLPDNT 222 Query: 222 DLFGTVSEDSLLKIN--DVRANNTTID--TVKCPQPFNTLAFSHH--SSNLLAAAGMDSY 275 F + D+L+KI D A + +A+S S + +A A D Sbjct: 223 RRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRT 282 Query: 276 VYLY--DLRNMKEPLHHMSGHEDAVNNLEFS-THVDGVVVSSGSDNRLMMW 323 V ++ D ++ K ++ + S + V+ SG DN++ +W Sbjct: 283 VLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 97.6 bits (241), Expect = 9e-21, Method: Composition-based stats. Identities = 43/266 (16%), Positives = 87/266 (32%), Gaps = 33/266 (12%) Query: 134 VATINGQGTVFLYSRSEGLQS---TLKFHKDNGYALSFS-TLVKGRLLSGSDDHTVALWE 189 +AT + T+ ++ Q TL H+ + ++++ L S S D V +W+ Sbjct: 84 LATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK 143 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWHNF-NKDLFGTVSEDSLLKINDVRANN--TTID 246 +G + +H +N W + S D + I + + I Sbjct: 144 EDNGVWNKVAE---HSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIV 200 Query: 247 TVKCPQPFNTLAFS----HHSSNLLAAAGMDSYVYLY---DLRNMKEPLHHMSGHEDAVN 299 N +++ ++ + G D+ V ++ D GH D V Sbjct: 201 IQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVR 260 Query: 300 NLEFSTH--VDGVVVSSGSDNRLMMW--DLKQIGAEQTPDDAEDGVPELIMVHAGHRSSV 355 ++ +S + ++ D +++W D K E+ P E Sbjct: 261 DVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWR--------- 311 Query: 356 NDFDLNPQIPWLVASAEEENILQVWK 381 + L S +N + +WK Sbjct: 312 --ASWSLSGNVLAISGG-DNKVTLWK 334 Score = 94.5 bits (233), Expect = 7e-20, Method: Composition-based stats. Identities = 39/188 (20%), Positives = 74/188 (39%), Gaps = 22/188 (11%) Query: 202 TWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN--DVRANNTTIDTVKCPQPFNTLAF 259 T + H D+I+D ++ T S D +KI D + P +A+ Sbjct: 63 TIGNAHDDLIHD-AVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAW 121 Query: 260 SHHS-SNLLAAAGMDSYVYLYDLRNM-KEPLHHMSGHEDAVNNLEFSTHVDG-VVVSSGS 316 +H +LA+ D V ++ N + S H+ +VN++ ++ H G V++ + S Sbjct: 122 AHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASS 181 Query: 317 DNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLN----PQIPWLVASAE 372 D ++ + + +DG +V GH VN P S Sbjct: 182 DGKI------------SIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGG 229 Query: 373 EENILQVW 380 +N++++W Sbjct: 230 CDNLVKIW 237 Score = 47.9 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 37/197 (18%), Positives = 70/197 (35%), Gaps = 28/197 (14%) Query: 16 LWKSNVPLMYDFVSETRLTWPSL-TVQWLPT---------------PVQELDGGFIKQEL 59 +WK + +++ V+E + S+ +V W P + E G + + Sbjct: 141 IWKEDNG-VWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPI 199 Query: 60 IIGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEE 119 +I H G N +A I+LP + + A ++ I A H + Sbjct: 200 VIQGHAIG--VNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSD 257 Query: 120 EITRARYMPQ--DPNIVATINGQGTVFLYSRSEGLQS------TLKFHKDNGYALSFSTL 171 + + P + +AT + TV ++++ T + D + S+S L Sbjct: 258 WVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWS-L 316 Query: 172 VKGRLLSGSDDHTVALW 188 L D+ V LW Sbjct: 317 SGNVLAISGGDNKVTLW 333 >4BZK-B nrPDB Length = 297 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 93/272 (34%), Gaps = 37/272 (13%) Query: 134 VATINGQGTVFLYSRSEGLQS---TLKFHKDNGYALSFS-TLVKGRLLSGSDDHTVALWE 189 +AT + T+ ++ TL H+ + + ++ L S S D V +W+ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWHNF-NKDLFGTVSEDSLLKINDVRANNTT--ID 246 +G V + +HS +N +W L S D + + + + N TT I Sbjct: 84 EENGRWSQIAV---HAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 Query: 247 TVKCPQPFNTLAFSH------------HSSNLLAAAGMDSYVYLYDLRNMKEPL---HHM 291 N+ +++ S G D+ V ++ + + + Sbjct: 141 IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTL 200 Query: 292 SGHEDAVNNLEFSTHV--DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 GH D V ++ +S V + S D ++W D E G + ++ Sbjct: 201 EGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW----------TQDNEQGPWKKTLLKE 250 Query: 350 GHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 V ++A + +N + +WK Sbjct: 251 EKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 94.5 bits (233), Expect = 7e-20, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 79/241 (32%), Gaps = 33/241 (13%) Query: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-H 217 H + + RL + S D T+ ++EV G+ K + T H + W H Sbjct: 8 HNELIHDAVLD-YYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTG-HEGPVWRVDWAH 63 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVK--CPQPFNTLAFSHHS-SNLLAAAGMDS 274 + + S D + I + V N++ ++ H LL A D Sbjct: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 275 YVYLYDLR-NMKEPLHHMSGHEDAVNNLEFST---HVDG---------VVVSSGSDNRLM 321 V + + + N + H VN+ ++ DG V+ G+DN + Sbjct: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 Query: 322 MWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI--PWLVASAEEENILQV 379 +W + GH V D +P + +AS ++ + Sbjct: 184 IWKYNSDAQTYVLE----------STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 Query: 380 W 380 W Sbjct: 234 W 234 Score = 84.5 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 46/240 (19%), Positives = 82/240 (34%), Gaps = 31/240 (12%) Query: 111 ITAKYEHEEEITRARY-MPQDPNIVATINGQGTVFLYSRSEG---LQSTLKFHKDNGYAL 166 I HE + R + P+ I+A+ + G V ++ G + H + ++ Sbjct: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV 105 Query: 167 SFSTLVKG-RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN------- 218 ++ G LL S D V++ E G + + D H+ +N W Sbjct: 106 QWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII---DAHAIGVNSASWAPATIEEDG 162 Query: 219 -----FNKDLFGTVSEDSLLKIN----DVRANNTTIDTVKCPQPFNTLAFSHH--SSNLL 267 F T D+L+KI D + +A+S + L Sbjct: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 Query: 268 AAAGMDSYVYLYDLRNM----KEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 A+ D ++ N K+ L D + +S V+ SG DN++ +W Sbjct: 223 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWS-LSGNVLALSGGDNKVTLW 281 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 30/77 (38%), Gaps = 13/77 (16%) Query: 306 HVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL-NPQI 364 + + + SD + ++++ E +LI GH V D +P+ Sbjct: 19 YYGKRLATCSSDKTIKIFEV------------EGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 365 PWLVASAEEENILQVWK 381 ++AS + + +WK Sbjct: 67 GTILASCSYDGKVLIWK 83 >5CXC-A nrPDB Length = 510 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 49/270 (18%), Positives = 98/270 (36%), Gaps = 42/270 (15%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG------LQSTLK--FHKDNGYALS 167 H I A+++ D +A+ TV ++ +E L+ TL+ H + L Sbjct: 190 GHTASIKAAKFLTSDR--LASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLD 247 Query: 168 FSTLVKGRLLSGSDDHTVALWEVGSGGDP---------------TKPVRTWND------- 205 K +L+ S D + W P K + + Sbjct: 248 VDGHSK-HILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLG 306 Query: 206 ---LHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAF--- 259 +H+ + ++ + + S+D ++ D+ + T+ P +L+ Sbjct: 307 LWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQ-VVSTLTLTHPLLSLSALTR 365 Query: 260 SHHSSNLLAAAGMDSYVYLYDLR--NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSD 317 + +S LLAA ++ + D R + + + GH + V +L S + +VS D Sbjct: 366 AGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHD 425 Query: 318 NRLMMWDLKQIGAEQTPDDAEDGVPELIMV 347 +WDL+ + + + GV E + V Sbjct: 426 GTCRVWDLRSVRPATKEEGSLGGVSEPVYV 455 Score = 81.0 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 40/287 (13%), Positives = 70/287 (24%), Gaps = 74/287 (25%) Query: 171 LVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED 230 + R+LS S D + +W T P + + H+ I K+ D + D Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGS-HGGHTASIKAAKF--LTSDRLASAGMD 212 Query: 231 SLLKIND-------VRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN 283 +++ T++ + L HS ++L A D + + Sbjct: 213 RTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASK 271 Query: 284 MKEP----------------------LHHMSG-------HEDAVNNLEFSTHVDGVVVSS 314 P G H F V S+ Sbjct: 272 ASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSA 331 Query: 315 GSDNRLMMWDLKQIGAEQTP----------------------------------DDAEDG 340 D+ + DL T D Sbjct: 332 SQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASS 391 Query: 341 VPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLP 387 +M GH + V +P+ + + S + +VW P Sbjct: 392 ATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRP 438 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 32/165 (19%), Positives = 60/165 (36%), Gaps = 15/165 (9%) Query: 217 HNFNKDLFGTVSEDSLLKINDVR----ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM 272 ++ + S D LL+I + A + + F +S+ LA+AGM Sbjct: 154 VQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFL--TSDRLASAGM 211 Query: 273 DSYVYLYDLRNMK------EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 D V ++ +P + GH +V+ L+ H ++ + +D + W Sbjct: 212 DRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILT-ASADGAIGFWSAS 270 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASA 371 + A + DA + SSV+ P W + +A Sbjct: 271 KASAPE--PDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTA 313 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 21/111 (18%), Positives = 38/111 (34%), Gaps = 31/111 (27%) Query: 294 HEDAVNNLEF----ST---------------HVDGVVVSSGSDNRLMMWDLKQIGAEQTP 334 H+D V+ ++ S V+S+ D L +W+ +P Sbjct: 125 HDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSP 184 Query: 335 DDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 + H GH +S+ +ASA + ++VWK + S Sbjct: 185 SGS----------HGGHTASIKAAKFLTSDR--LASAGMDRTVRVWKYTES 223 Score = 29.8 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 13/96 (13%), Positives = 33/96 (34%), Gaps = 10/96 (10%) Query: 104 APRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQST-----LKF 158 A + + H ++ P++ + + + GT ++ +T L Sbjct: 389 ASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGG 448 Query: 159 HKDNGYAL---SFSTLVKGRLLSGSDDHTVA--LWE 189 + Y + S+++ K + D V +W+ Sbjct: 449 VSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVWD 484 >5L9T-R nrPDB Length = 493 Score = 99.9 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 51/265 (19%), Positives = 101/265 (38%), Gaps = 29/265 (10%) Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEGL-QSTLKFHKDNGYALSFSTLVKGRLLSG 179 +T + + N+VA +G V ++ + G S L+ H AL+++ L SG Sbjct: 232 VTSVGWS-ERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ---LSSG 287 Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVR 239 S D + ++ + P + R H + KW + L + D+ L + + Sbjct: 288 SRDRMILQRDIRT--PPLQSERRLQG-HRQEVCGLKWSTDH-QLLASGGNDNKLLVWNHS 343 Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG--MDSYVYLYDLRNMKEPLHHMSGHEDA 297 + + + +A+S H LLA+ G D + ++ +PL + Sbjct: 344 SLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLT-GQPLQCIDTGSQ- 401 Query: 298 VNNLEFSTHVDGVVVSSGSD-NRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVN 356 V NL +S H + +V + G N++++W + + GH V Sbjct: 402 VCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQ--------------VAKLTGHSYRVL 447 Query: 357 DFDLNPQIPWLVASAEEENILQVWK 381 ++P +V + + L+ W Sbjct: 448 YLAMSPDGEAIV-TGAGDETLRFWN 471 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 26/185 (14%), Positives = 62/185 (33%), Gaps = 16/185 (8%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSE-GLQSTLKFHKDNGYALSFSTLVKG 174 H +E+ ++ D ++A+ + +++ S H A+++S G Sbjct: 311 GHRQEVCGLKWS-TDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHG 369 Query: 175 RLLSGSD--DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED-S 231 L SG D + W +G +P++ + + + W +L T + Sbjct: 370 LLASGGGTADRCIRFWNTLTG----QPLQCIDTGSQ--VCNLAWSKHANELVSTHGYSQN 423 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL----RNMKEP 287 + + + LA S + D + +++ R+ KE Sbjct: 424 QILVWKYPSLTQVAKLTGHSYRVLYLAMSP-DGEAIVTGAGDETLRFWNVFSKTRSTKES 482 Query: 288 LHHMS 292 + ++ Sbjct: 483 VSVLN 487 >6EMK-B nrPDB Length = 303 Score = 98.3 bits (243), Expect = 6e-21, Method: Composition-based stats. Identities = 36/252 (14%), Positives = 74/252 (29%), Gaps = 29/252 (11%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGR 175 H +T + QD + T + GT+ ++ H + +G Sbjct: 73 GHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPN-QGE 130 Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 L+S D + +W++G + D + + + + + Sbjct: 131 LISCDRDGNIRIWDLGENQCTHQL-----TPEDDTSLQSLSMASDGSMLAAANTKGNCYV 185 Query: 236 N------DVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH 289 D + S LA D ++ + + + Sbjct: 186 WEMPNHTDASHLKPVTKFRAHSTYITRILLS-SDVKHLATCSADHTARVWSIDDDFKLET 244 Query: 290 HMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 + GH+ V + FS +V++ SD+ + +WDL E++ + Sbjct: 245 TLDGHQRWVWDCAFS-ADSAYLVTASSDHYVRLWDLS--------------TREIVRQYG 289 Query: 350 GHRSSVNDFDLN 361 GH LN Sbjct: 290 GHHKGAVCVALN 301 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 40/257 (15%), Positives = 99/257 (38%), Gaps = 19/257 (7%) Query: 133 IVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGS 192 I+ + T+ + G+ S H D+ T K L + V L+++ + Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDIRT 62 Query: 193 GGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQ 252 PV ++ H + + N+ + + SED +K+ DVR+ + K Sbjct: 63 TN--PNPVASFEG-HRGNVTSVSFQQDNRWMVTS-SEDGTIKVWDVRSP-SIPRNYKHNA 117 Query: 253 PFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHED-AVNNLEFSTHVDGVV 311 P N + + L+ + D + ++DL + H ++ +D ++ +L ++ ++ Sbjct: 118 PVNEVVIHPNQGELI-SCDRDGNIRIWDL-GENQCTHQLTPEDDTSLQSLSMAS-DGSML 174 Query: 312 VSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASA 371 ++ + +W++ P+ + + + H + + L+ + L A+ Sbjct: 175 AAANTKGNCYVWEM--------PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL-ATC 225 Query: 372 EEENILQVWKCSHSLPI 388 ++ +VW + Sbjct: 226 SADHTARVWSIDDDFKL 242 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 36/198 (18%), Positives = 70/198 (35%), Gaps = 9/198 (4%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFST 170 I Y+H + P ++ + + G + ++ E + +D+ S S Sbjct: 109 IPRNYKHNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM 167 Query: 171 LVKGRLLSGSDDH-TVALWEVGSGGD--PTKPVRTWNDLHSDIINDNKWHNFNKDLFGTV 227 G +L+ ++ +WE+ + D KPV + + I + + T Sbjct: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL--LSSDVKHLATC 225 Query: 228 SEDSLLKINDVRAN-NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE 286 S D ++ + + + AFS S L A D YV L+DL + +E Sbjct: 226 SADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS-ADSAYLVTASSDHYVRLWDL-STRE 283 Query: 287 PLHHMSGHEDAVNNLEFS 304 + GH + + Sbjct: 284 IVRQYGGHHKGAVCVALN 301 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 24/126 (19%), Positives = 49/126 (38%), Gaps = 17/126 (13%) Query: 263 SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 S +L +AG D + ++ + + VN LE D ++++ + + Sbjct: 1 MSVILVSAGYDHTIRFWEALT-GVCSRTIQHSDSQVNRLEI--TNDKKLLATAGHQNVRL 57 Query: 323 WDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 +D++ P + GHR +V W+V ++ E+ ++VW Sbjct: 58 YDIRTTN------------PNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDV 104 Query: 383 -SHSLP 387 S S+P Sbjct: 105 RSPSIP 110 Score = 31.3 bits (69), Expect = 0.74, Method: Composition-based stats. Identities = 6/57 (10%), Positives = 18/57 (31%), Gaps = 2/57 (3%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTL 171 H+ + + D + T + V L+ + + H ++ + + Sbjct: 248 GHQRWVWDCAFS-ADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV 303 >5A31-R nrPDB Length = 386 Score = 97.6 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 54/287 (18%), Positives = 104/287 (36%), Gaps = 30/287 (10%) Query: 99 QSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTLK 157 +S + + + E E T ++ + +A G V +Y TL Sbjct: 112 KSIFLTDNNTGDVVHLCDTENEYTSLSWIGAGSH-LAVGQANGLVEIYDVMKRKCIRTLS 170 Query: 158 FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 H D LS++ V L SGS DH + + P + H+ + KW+ Sbjct: 171 GHIDRVACLSWNNHV---LTSGSRDHRI----LHRDVRMPDPFFETIESHTQEVCGLKWN 223 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG--MDSY 275 + L + D+++ + + + + + + +A+S H +LA G D Sbjct: 224 VADNKL-ASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRR 282 Query: 276 VYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDN-RLMMWDLKQIGAEQTP 334 + ++++ + SG + N+ +S + + +V S G L +WD + Sbjct: 283 LKIWNVNTSIKMSDIDSG--SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDP---- 336 Query: 335 DDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 I + GH V L+ +V S + L+ WK Sbjct: 337 ----------IAILKGHSFRVLHLTLSNDGTTVV-SGAGDETLRYWK 372 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 30/169 (17%), Positives = 60/169 (35%), Gaps = 12/169 (7%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTLVKGR 175 H +E+ ++ D N +A+ V +Y S+ T HK A+++S +G Sbjct: 213 HTQEVCGLKWNVAD-NKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGV 271 Query: 176 LLSGSD--DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS-L 232 L +G D + +W V + + I + W +L + Sbjct: 272 LATGGGTADRRLKIWNVNTSIKMSDIDSG------SQICNMVWSKNTNELVTSHGYSKYN 325 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL 281 L + D + + L S+ + +++ AG D + + L Sbjct: 326 LTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAG-DETLRYWKL 373 >6GMH-W nrPDB Length = 305 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 58/320 (18%), Positives = 105/320 (32%), Gaps = 63/320 (19%) Query: 106 RSNIRITAKYEHEEEITRARY---MPQDPNIVATINGQGTVFLY---SRSEGLQSTLKFH 159 + I + H++ I + ++ V T + V ++ LQ +L+ H Sbjct: 4 QYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH 63 Query: 160 KDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTK----PVRTWN----------- 204 + ++ S + S S D + LW++ +G PV W Sbjct: 64 QLGVVSVDISHTLP-IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLA 122 Query: 205 -DLHSDIIN---------------------DNKWHNFNKDLFGTVSEDSLLKINDVRANN 242 H +N + + + + D ++ I D+ Sbjct: 123 TGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSP-DGKYLASGAIDGIINIFDIATGK 181 Query: 243 TTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLE 302 P +L FS S LL A D Y+ +YD+++ +SGH V N+ Sbjct: 182 LLHTLEGHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQHANLA-GTLSGHASWVLNVA 239 Query: 303 FSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNP 362 F D VSS SD + +WD+ G + H+ V N Sbjct: 240 FCP-DDTHFVSSSSDKSVKVWDV--------------GTRTCVHTFFDHQDQVWGVKYNG 284 Query: 363 QIPWLVASAEEENILQVWKC 382 +V S ++ + ++ C Sbjct: 285 NGSKIV-SVGDDQEIHIYDC 303 Score = 95.6 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 34/229 (14%), Positives = 84/229 (36%), Gaps = 25/229 (10%) Query: 159 HKDNGYALSFSTL---VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNK 215 H D +++++ T +++GS D V +W + + +++ + Sbjct: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDI 72 Query: 216 WHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSY 275 H + + S D+ +++ D+ P TLAFS S LA Sbjct: 73 SHTL--PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSP-DSQYLATGTHVGK 129 Query: 276 VYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD 335 V ++ + + K+ + + + ++ +S + S D + ++D+ Sbjct: 130 VNIFGVESGKKE-YSLDTRGKFILSIAYSP-DGKYLASGAIDGIINIFDI---------- 177 Query: 336 DAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 +L+ GH + +P L+ +A ++ ++++ H Sbjct: 178 ----ATGKLLHTLEGHAMPIRSLTFSPD-SQLLVTASDDGYIKIYDVQH 221 >4BH6-A nrPDB Length = 308 Score = 96.0 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 54/287 (18%), Positives = 104/287 (36%), Gaps = 30/287 (10%) Query: 99 QSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTLK 157 +S + + + E E T ++ + +A G V +Y TL Sbjct: 43 KSIFLTDNNTGDVVHLCDTENEYTSLSWIGAGSH-LAVGQANGLVEIYDVMKRKCIRTLS 101 Query: 158 FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 H D LS++ V L SGS DH + + P + H+ + KW+ Sbjct: 102 GHIDRVACLSWNNHV---LTSGSRDHRI----LHRDVRMPDPFFETIESHTQEVCGLKWN 154 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG--MDSY 275 + L + D+++ + + + + + + +A+S H +LA G D Sbjct: 155 VADNKL-ASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRR 213 Query: 276 VYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDN-RLMMWDLKQIGAEQTP 334 + ++++ + SG + N+ +S + + +V S G L +WD + Sbjct: 214 LKIWNVNTSIKMSDIDSG--SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDP---- 267 Query: 335 DDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 I + GH V L+ +V S + L+ WK Sbjct: 268 ----------IAILKGHSFRVLHLTLSNDGTTVV-SGAGDETLRYWK 303 Score = 67.9 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 30/169 (17%), Positives = 60/169 (35%), Gaps = 12/169 (7%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYALSFSTLVKGR 175 H +E+ ++ D N +A+ V +Y S+ T HK A+++S +G Sbjct: 144 HTQEVCGLKWNVAD-NKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGV 202 Query: 176 LLSGSD--DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS-L 232 L +G D + +W V + + I + W +L + Sbjct: 203 LATGGGTADRRLKIWNVNTSIKMSDIDSG------SQICNMVWSKNTNELVTSHGYSKYN 256 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL 281 L + D + + L S+ + +++ AG D + + L Sbjct: 257 LTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAG-DETLRYWKL 304 Score = 31.3 bits (69), Expect = 0.81, Method: Composition-based stats. Identities = 18/136 (13%), Positives = 36/136 (26%), Gaps = 47/136 (34%) Query: 105 PRSNIRITAKYEHEEEITRARYMPQDPNIVATING--QGTVFLYSRSE------------ 150 S I EH+ + + P ++AT G + +++ + Sbjct: 174 GTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ 233 Query: 151 --------------------------------GLQSTLKFHKDNGYALSFSTLVKGRLLS 178 + LK H L+ S ++S Sbjct: 234 ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS-NDGTTVVS 292 Query: 179 GSDDHTVALWEVGSGG 194 G+ D T+ W++ Sbjct: 293 GAGDETLRYWKLFDKP 308 >4G56-B nrPDB Length = 357 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 78/212 (36%), Gaps = 9/212 (4%) Query: 113 AKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRS-EGLQSTLKFHKDNGYALSFSTL 171 AKYEH++ + D + +V ++ S + + + H ++ Sbjct: 134 AKYEHDDIVKTLSVF-SDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPG 192 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII-NDNKWHNFNKDLFGTVSED 230 LS +D + LW+ KP + SD I WH D F E Sbjct: 193 KDTIFLSCGEDGRILLWD----TRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDET 248 Query: 231 SLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHH 290 + + +++ ++ + Q LA+S+HSS LA+ D V + D + Sbjct: 249 GNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLD--ADFSEVFR 306 Query: 291 MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 H D V + +S + G D++++ Sbjct: 307 DLSHRDFVTGVAWSPLDHSKFTTVGWDHKVLH 338 Score = 84.5 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 45/259 (17%), Positives = 82/259 (31%), Gaps = 31/259 (11%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG----LQSTLKF-HKDNGYA 165 TA + E +T ++ + + + G V L+ E + K+ H D Sbjct: 87 CTAGVQTEAGVTDVAWVSEKG--ILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKT 144 Query: 166 LSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFG 225 LS + +SG D +V +W++ K V + HS +N +F Sbjct: 145 LSV-FSDGTQAVSGGKDFSVKVWDLS-----QKAVLKSYNAHSSEVNCVAACPGKDTIFL 198 Query: 226 TVSEDSLLKINDVRANNTT--IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN 283 + ED + + D R ID ++ + + A V L +++N Sbjct: 199 SCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKN 258 Query: 284 MKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPE 343 + H + L +S H + S D + + D Sbjct: 259 PDSA-QTSAVHSQNITGLAYSYHSSPFLASISEDCTVAV---------------LDADFS 302 Query: 344 LIMVHAGHRSSVNDFDLNP 362 + HR V +P Sbjct: 303 EVFRDLSHRDFVTGVAWSP 321 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 34/250 (13%), Positives = 77/250 (30%), Gaps = 24/250 (9%) Query: 138 NGQGTVFLYS-----RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGS 192 G+++++ +E L + + +++ + +L SD V LWE+ Sbjct: 67 TWGGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKG--ILVASDSGAVELWEILE 124 Query: 193 GGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQ 252 + + H DI+ + + +D +K+ D+ Sbjct: 125 K-ESLLVNKFAKYEHDDIVKTLSVF-SDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSS 182 Query: 253 PFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAV-NNLEFSTHVDGVV 311 N +A + + G D + L+D R K D + ++ + D Sbjct: 183 EVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTF 242 Query: 312 VSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASA 371 + + ++K + QT H ++ + +AS Sbjct: 243 ACGDETGNVSLVNIKNPDSAQTSAV--------------HSQNITGLAYSYHSSPFLASI 288 Query: 372 EEENILQVWK 381 E+ + V Sbjct: 289 SEDCTVAVLD 298 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 49/143 (34%), Gaps = 20/143 (13%) Query: 248 VKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG---HEDAVNNLEFS 304 V+ +A+ L+A+ V L+++ + L + H+D V L Sbjct: 91 VQTEAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNKFAKYEHDDIVKTLSVF 148 Query: 305 THVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI 364 + VS G D + +WDL Q ++ + H S VN P Sbjct: 149 S-DGTQAVSGGKDFSVKVWDLSQKA--------------VLKSYNAHSSEVNCVAACPGK 193 Query: 365 PWLVASAEEENILQVWKCSHSLP 387 + S E+ + +W P Sbjct: 194 DTIFLSCGEDGRILLWDTRKPKP 216 >6J6H-n nrPDB Length = 455 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 57/310 (18%), Positives = 102/310 (32%), Gaps = 67/310 (21%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG--LQSTLKFHKDNGYALSFSTLVK 173 H E T +++P+ +++ + T+ ++ + H AL F+ + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 Query: 174 GRLLSGSDDHTVALWEVGSG-------------------GDPTKPVRTWN---------- 204 LS S D +V +W+ +G +P + + + Sbjct: 220 S-FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 Query: 205 -----------DLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRAN---NTTIDTVKC 250 D H I K+ + SED ++I + + N DT + Sbjct: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISS-SEDKTVRIWENQINVPIKQISDTAQH 337 Query: 251 PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL--RNMKEPLHHMSGHEDAVNNLEFSTHVD 308 PF + H S N A MD+ +Y + L + + P GH A + + D Sbjct: 338 SMPFLNV---HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD 394 Query: 309 GVVVSSG-SDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI-PW 366 G + SG S +RL WD + L + + D +PQ Sbjct: 395 GRYICSGDSKSRLFTWD-------------WNTSRLLNNIKIPGNKPITQVDWHPQETSK 441 Query: 367 LVASAEEENI 376 ++ S I Sbjct: 442 VICSGAAGKI 451 Score = 84.9 bits (208), Expect = 6e-17, Method: Composition-based stats. Identities = 39/227 (17%), Positives = 77/227 (33%), Gaps = 21/227 (9%) Query: 149 SEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHS 208 + + H + AL F +LSG +DHT+ +W+ + +R + H+ Sbjct: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE---CLRDFQG-HN 206 Query: 209 DIINDNKWHNFNKDLFGTVSEDSLLKINDVRAN--NTTIDTVKCPQPFNTLAFSHHSSNL 266 I ++ + F + S D +KI D T + P + + H Sbjct: 207 KPIKALRF-TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE--- 262 Query: 267 LAAAGMDSYVYLYDLRNMKEP--LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD 324 +S + YD R + + H ++ L++ +SS D + +W+ Sbjct: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWE 321 Query: 325 LKQIGAEQTPDDAEDGVPELIMVHAGH--------RSSVNDFDLNPQ 363 + + D + VH + + F L P+ Sbjct: 322 NQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPK 368 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 8/45 (17%), Positives = 18/45 (40%) Query: 341 VPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 ++I + GH P+ L+ S ++ +++W H Sbjct: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD 195 >5WBU-D nrPDB Length = 328 Score = 91.0 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 37/256 (14%), Positives = 92/256 (35%), Gaps = 16/256 (6%) Query: 129 QDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALW 188 DP I+AT TV + G+ + H+D+ T + + + H + ++ Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMY 70 Query: 189 EVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTID-T 247 ++ S P+ +++ ++ + I +H + ++ T ED +I D+R+ N Sbjct: 71 DLNSNN--PNPIISYDGVNKN-IASVGFHEDGRWMY-TGGEDCTARIWDLRSRNLQCQRI 126 Query: 248 VKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHV 307 + P N + + + L+ ++++DL+ ++ + Sbjct: 127 FQVNAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEV-SITSAHIDPDA 184 Query: 308 DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWL 367 + + + N +W+L ++ H +P L Sbjct: 185 SYMAAVNSTGN-CYVWNLTGGIGDEVTQLIPKTKIP------AHTRYALQCRFSPDST-L 236 Query: 368 VASAEEENILQVWKCS 383 +A+ + ++W+ S Sbjct: 237 LATCSADQTCKIWRTS 252 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 50/335 (14%), Positives = 97/335 (28%), Gaps = 86/335 (25%) Query: 89 DPQEEAGEEYQSSLPAPRSNIRITAKY--EHEEEITRARYMPQDPNIVATINGQ--GTVF 144 DP A Y ++ +++ I + + ++ P D +++A Q Sbjct: 13 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQHIRMYD 71 Query: 145 LYSRSEGLQSTLKFHKDNGYALSFSTLVKGR-LLSGSDDHTVALWEVGSGGDPTKPVRTW 203 L S + + N ++ F GR + +G +D T +W++ S + + Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 129 Query: 204 NDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANN--------------------- 242 N IN H +L + + I D++ ++ Sbjct: 130 N----APINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDA 184 Query: 243 -----------------------------TTIDTVKCPQPFNTLAFSHHSSNLLAAAGMD 273 + FS S LLA D Sbjct: 185 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSAD 243 Query: 274 SYVYLYDLRN--MKEPLHHMSGH-----EDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 ++ N + L SG+ + FS +V++ SDN +W ++ Sbjct: 244 QTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS-GDSQYIVTASSDNLARLWCVE 302 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLN 361 E+ + GH+ +V N Sbjct: 303 --------------TGEIKREYGGHQKAVVCLAFN 323 Score = 34.8 bits (78), Expect = 0.074, Method: Composition-based stats. Identities = 12/71 (16%), Positives = 25/71 (35%), Gaps = 7/71 (9%) Query: 110 RITAKYEHEEEITR-----ARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNG 163 ++ K + E +R + D + T + L+ G ++ H+ Sbjct: 259 ELSIKSGNPGESSRGWMWGCAFS-GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 317 Query: 164 YALSFSTLVKG 174 L+F+ V G Sbjct: 318 VCLAFNDSVLG 328 >5A9Q-7 nrPDB Length = 360 Score = 90.2 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 50/283 (17%), Positives = 108/283 (38%), Gaps = 38/283 (13%) Query: 134 VATINGQGTVFLYSRSE----GLQSTLKFHKDNGYALSFS-TLVKGRLLSGSDDHTVALW 188 +AT + +V ++ +SE ++ K H + + ++++ L S S D T A+W Sbjct: 27 MATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVW 86 Query: 189 EVGSGGDPTK-------PVRTWNDLHSDIINDNKWHNFNKDL-FGTVSEDSLLKINDVR- 239 E G K RT + D K+ + L T S D +++I + Sbjct: 87 EEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPD 146 Query: 240 ----ANNTTIDTVKCPQPFNTLAFSHHSSN----LLAAAGMDS------YVYLYDLRNMK 285 + + + C + ++++ SS ++A DS V +++ Sbjct: 147 VMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENT 206 Query: 286 E---PLHHMSGHEDAVNNLEFSTHVD---GVVVSSGSDNRLMMWDLKQIGAEQTPDDAED 339 + D V+++ F+ ++ ++ + D + ++ LK + E T Sbjct: 207 RKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPVRKELTSSGGPT 264 Query: 340 GVPELIMV-HAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 I+ H S V N ++AS+ ++ +++WK Sbjct: 265 KFEIHIVAQFDNHNSQVWRVSWNITGT-VLASSGDDGCVRLWK 306 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 45/269 (16%), Positives = 84/269 (31%), Gaps = 33/269 (12%) Query: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-H 217 HKD + +SF R+ + S D +V +W+ GD +W HS + W H Sbjct: 11 HKDLIHDVSFDFH-GRRMATCSSDQSVKVWDKSESGDWH-CTASWKT-HSGSVWRVTWAH 67 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQP------------FNTLAFSH-HSS 264 + + S D + + + + F+ H Sbjct: 68 PEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMG 127 Query: 265 NLLAAAGMDSYVYLYDLRNMKEPLHHMSGHED----AVNNLEFSTHV----DGVVVSSGS 316 +LA D V +Y+ ++ HE + + + ++ ++ Sbjct: 128 LMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSD 187 Query: 317 DNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIP---WLVASAEE 373 D+ QI L+ V V+D P + ++A A + Sbjct: 188 DSSPNAMAKVQIFEYNENTRKYAKAETLMTV----TDPVHDIAFAPNLGRSFHILAIATK 243 Query: 374 E-NILQVWKCSHSLPIVGGPPKVNKDIIS 401 + I + L GGP K I++ Sbjct: 244 DVRIFTLKPVRKELTSSGGPTKFEIHIVA 272 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 39/253 (15%), Positives = 85/253 (33%), Gaps = 49/253 (19%) Query: 117 HEEEITRARY-MPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKD------------N 162 H + R + P+ ++A+ + T ++ G L+ + Sbjct: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTS 115 Query: 163 GYALSFSTLVKG-RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNF-- 219 + F+ G L + S D V ++E + ++ + W+ Sbjct: 116 VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSS 175 Query: 220 --NKDLFGTVSEDSL------LKIN----DVRANNTTIDTVKCPQPFNTLAFSHHSS--- 264 + + S+DS ++I + R + P + +AF+ + Sbjct: 176 RAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSF 235 Query: 265 NLLAAAGMDSYVYLYDLRNMKEPLHHMSG--------------HEDAVNNLEFSTHVDGV 310 ++LA A D V ++ L+ +++ L G H V + ++ V Sbjct: 236 HILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWN-ITGTV 292 Query: 311 VVSSGSDNRLMMW 323 + SSG D + +W Sbjct: 293 LASSGDDGCVRLW 305 Score = 35.5 bits (80), Expect = 0.038, Method: Composition-based stats. Identities = 16/123 (13%), Positives = 33/123 (26%), Gaps = 18/123 (14%) Query: 86 SNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDP---NIVATINGQGT 142 + P A + R + + + + P +I+A Sbjct: 187 DDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVR 246 Query: 143 VFLYSRSE--------------GLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALW 188 +F + + H + +S++ + L S DD V LW Sbjct: 247 IFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWN-ITGTVLASSGDDGCVRLW 305 Query: 189 EVG 191 + Sbjct: 306 KAN 308 >5A9Q-0 nrPDB Length = 380 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 58/347 (16%), Positives = 117/347 (33%), Gaps = 43/347 (12%) Query: 48 QELDGGFIKQELIIGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRS 107 + L G ++ T + EENY+ I + ++ ++ Sbjct: 19 RPLPPGSLQTAETFATGSWDNEENYISLWSIG--------DFGNLDSDGGFEGDHQLLCD 70 Query: 108 NIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQS------TLKFHKD 161 H ++ ++ Q+ + A+ G TVFL+ + S T +H Sbjct: 71 -------IRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTG 123 Query: 162 NGYALSFSTLVKGRLL------SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNK 215 G S G + + +D + L+ D + VRT ++ S ++ Sbjct: 124 PGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFRA----DHKEAVRTIDNADSSTLHAVT 179 Query: 216 WHNFNKDLFGTVSEDSLLKINDVR----ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG 271 + TV+ LKI D R + + P + + + +++A G Sbjct: 180 FLR--TPEILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGG 237 Query: 272 MDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAE 331 D + ++D+R P+ + HE + + F + + D L WD E Sbjct: 238 QDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPE 297 Query: 332 QTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI--PWLVASAEEENI 376 ++ + G H S N +++ + WL ++ I Sbjct: 298 KSSLFHQGGRS---STFLSHSIS-NQANVHQSVISSWLSTDPAKDRI 340 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 45/301 (14%), Positives = 94/301 (31%), Gaps = 47/301 (15%) Query: 119 EEITRARYMP------QDPNIVATINGQG---TVFLYSR--------------SEGLQST 155 ++I++ R+ P Q AT + + L+S L Sbjct: 11 QKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCD 70 Query: 156 LKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNK 215 ++ H D L F + S + TV L + T H+ + + Sbjct: 71 IRHHGD-VMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSY 129 Query: 216 WHNF------NKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 N TV ED + + + + T+ A + + + Sbjct: 130 SSAPCTGVVCNNPEIVTVGEDGRINLFRAD-HKEAVRTIDNADSSTLHAVTFLRTPEILT 188 Query: 270 AGMDSYVYLYDLRNMKEP---LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 + ++D R + ++G ++ ++ + VV + G D L +WD++ Sbjct: 189 VNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVR 248 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 Q + + H + + + +P P + + E+ L W S + Sbjct: 249 QG-------------TMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDV 295 Query: 387 P 387 P Sbjct: 296 P 296 >6CHG-A nrPDB Length = 312 Score = 89.5 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 44/269 (16%), Positives = 93/269 (34%), Gaps = 26/269 (9%) Query: 122 TRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSD 181 T + P D ++A + S + HK+ L +S K + SGS+ Sbjct: 17 TSCQISP-DGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSK-CIASGSE 74 Query: 182 DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRAN 241 D TV + + G +R H+ + ++N ++ + S D +K V + Sbjct: 75 DFTVEITHIIYG-----RIRRLMG-HTAPVISICYNNK-GNILCSSSMDESIKEWHVLSG 127 Query: 242 NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDA---- 297 ++ S++L++ D + ++D L ++ +D Sbjct: 128 TALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTE-SGHCLKTLTYDKDWIAED 186 Query: 298 ----VNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 ++ ++FS ++ DN + +W+ + +T + + G Sbjct: 187 GVVPISTVKFS-RNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLE- 244 Query: 354 SVNDFDLNPQIP-WLVASAEEENILQVWK 381 + PQ LV S + + VW Sbjct: 245 -----LIYPQGKDPLVISGNDSGSMCVWN 268 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 17/126 (13%), Positives = 47/126 (37%), Gaps = 25/126 (19%) Query: 120 EITRARYMPQDPNIVATINGQGTVFLYSRSEG--LQSTLKFHKDNGYALSFSTLV----- 172 I+ ++ ++ + + V L+ + G +++ L H++ L ++ + Sbjct: 190 PISTVKFS-RNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYP 248 Query: 173 ---KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 ++SG+D ++ +W V S K ++ H + + + S Sbjct: 249 QGKDPLVISGNDSGSMCVWNVYSKNLVQKI--------------DEKHRNSPLISISASY 294 Query: 230 DSLLKI 235 D + + Sbjct: 295 DKVATL 300 >5N4A-A nrPDB Length = 771 Score = 88.7 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 44/232 (18%), Positives = 82/232 (35%), Gaps = 25/232 (10%) Query: 153 QSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDP--TKPVRTWNDLHSDI 210 QS+ H + A+ ++ V L + SDD T+ W + + + + D+H Sbjct: 7 QSSANVHSELTAAVGWN--VWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYP 64 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 ++ K D+F D +KI R +L +S + LA A Sbjct: 65 VSSKKTQAGGTDVFAVACTDGSVKIL-SRTGRVEKSIEGHKGACISLRWS-YDGTALATA 122 Query: 271 GMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGA 330 G D V ++ RN ++ + V ++ ++ D + +GS+ + L Sbjct: 123 GEDGSVKIWS-RNGMLRS-TLAQADSPVYSIVWAYDCDQLCYCTGSNVVIK--SLSSNAK 178 Query: 331 EQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 + H V D +P I L+ + E+ +VW Sbjct: 179 QNA--------------WKAHDGVVLKVDWSP-INHLIITGGEDCKYKVWDS 215 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 36/206 (17%), Positives = 67/206 (32%), Gaps = 14/206 (6%) Query: 99 QSSLPAPRSNIRITAKY-EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLK 157 S+ R+ H+ R+ D +AT G+V ++SR+ L+STL Sbjct: 84 DGSVKILSRTGRVEKSIEGHKGACISLRWS-YDGTALATAGEDGSVKIWSRNGMLRSTLA 142 Query: 158 FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 Y++ ++ + + + + K H ++ W Sbjct: 143 QADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWK-------AHDGVVLKVDWS 195 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVY 277 N L T ED K+ D + P ++A++ S L A G + + Sbjct: 196 PIN-HLIITGGEDCKYKVWDS-FGRLLFQSGLFDYPVTSVAWAP-SGELFAVGGF-NTLQ 251 Query: 278 LYDLRNMKEPLHHMSGHEDAVNNLEF 303 L D R ++ L + Sbjct: 252 LCD-RMGWAYSKIHLNDTGSIMTLSW 276 Score = 77.9 bits (190), Expect = 6e-15, Method: Composition-based stats. Identities = 33/209 (15%), Positives = 72/209 (34%), Gaps = 16/209 (7%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRL 176 H ++ + ++ A G+V + SR+ ++ +++ HK +L +S L Sbjct: 61 HWYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRWS-YDGTAL 119 Query: 177 LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 + +D +V +W +R+ + W L + ++K Sbjct: 120 ATAGEDGSVKIWSRNG------MLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSL 173 Query: 237 DVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHED 296 A + +S + +L+ G D ++D L SG D Sbjct: 174 SSNAKQNAWK--AHDGVVLKVDWSPIN-HLIITGGEDCKYKVWD---SFGRLLFQSGLFD 227 Query: 297 A-VNNLEFSTHVDGVVVSSGSDNRLMMWD 324 V ++ ++ + + G N L + D Sbjct: 228 YPVTSVAWAPSGE-LFAVGGF-NTLQLCD 254 >4XFV-A nrPDB Length = 792 Score = 87.9 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 50/295 (16%), Positives = 97/295 (32%), Gaps = 53/295 (17%) Query: 134 VATINGQGTVFLYSR----SEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWE 189 + T+ L+ ++G+ +TLK H+ + F ++S S+DH V +W+ Sbjct: 33 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSD-FMVSASEDHHVKIWK 91 Query: 190 VGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN--DVRANNTTIDT 247 + ++T I+ + L D + I +++ + + Sbjct: 92 FTD-YSHLQCIQTIQHYSKTIVALSA----LPSLISVGCADGTISIWRQNIQNDEFGL-- 144 Query: 248 VKCPQPFNTLAFSH---------HSSNLLAAAGMDSYVYL--YDLRNMKEP----LHHMS 292 F LLA G + V++ + L + + + Sbjct: 145 -AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELE 203 Query: 293 GHEDAVNNLEF---STHVDGVVVSSGSDNRLMMW-----DLKQIGAEQT----------- 333 GHED V +L F T D ++ S D + +W DL E + Sbjct: 204 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQY 263 Query: 334 ---PDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 DD + GH ++ + L+A+ + L VW+ + Sbjct: 264 KFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATA-DTSLMVWEPDET 317 Score = 78.7 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 44/328 (13%), Positives = 102/328 (31%), Gaps = 68/328 (20%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSE----GLQSTLKFHKDNGYALSFSTL 171 HE E+T R++P D + + + + V ++ ++ T++ + AL + Sbjct: 61 GHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL---SA 116 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNF---------NKD 222 + + G D T+++W D + H I ++ K Sbjct: 117 LPSLISVGCADGTISIWRQNIQNDE------FGLAHEFTIKKGFFYPLCLSLSKVEEKKY 170 Query: 223 LFGTVSED-----SLLKIND--VRANNTTIDTVKCPQPFNTLAFSHHSS---NLLAAAGM 272 L + + ++D + + +LAF H + LL + Sbjct: 171 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 230 Query: 273 DSYVYLYDLR---------NMKEPLHHMS-----------------------GHEDAVNN 300 D Y+ L+ +R + L +S GH+D +++ Sbjct: 231 DRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISS 290 Query: 301 LEFSTHVDGVVVSSGSDNRLMMW--DLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDF 358 L++ ++ ++ +D LM+W D + E + Sbjct: 291 LQWHESRLQLLAAT-ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCL 349 Query: 359 DLNPQIPWLVASAEEENILQVWKCSHSL 386 + + + ++W ++ Sbjct: 350 WFTHERMDFFLTNGKTGSWRMWATKDNI 377 Score = 58.7 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 38/273 (13%), Positives = 79/273 (28%), Gaps = 62/273 (22%) Query: 116 EHEEEITRARYMPQDP---NIVATINGQGTVFLYS------------------------R 148 HE+ + + Q+ ++ + + + L+ Sbjct: 204 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQY 263 Query: 149 SEGLQSTLK----------FHKDNGYALSFSTLVKGRLLSGSDDHTVALW--EVGSG--- 193 + L+ H D +L + +LL+ + D ++ +W + SG Sbjct: 264 KFQIDDELRVGINFEALIMGHDDWISSLQWHESRL-QLLAATADTSLMVWEPDETSGIWV 322 Query: 194 -----GDPTKPVRTWNDLHSDIINDNKWHNFNK-DLFGTVSEDSLLKIN---DVRANNTT 244 G+ + + S W + D F T + ++ D + Sbjct: 323 CSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQR 382 Query: 245 IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYL---YDLRNMKEPLHHMSGHE------ 295 + + +A+S LLA +D L + + HE Sbjct: 383 LGISGATKDVTDIAWSPSGEYLLAT-SLDQTTRLFAPWIYDASGRKREIATWHEFSRPQI 441 Query: 296 DAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 + + T D VS G + L +DL + Sbjct: 442 HGYDMICVETVTDTRFVSGGDEKILRSFDLPKG 474 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 31/185 (16%), Positives = 58/185 (31%), Gaps = 20/185 (10%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRS-EGLQSTLKF-----HKDNGYALSFST 170 H ITR ++ +D + ++ L+ R+ E L+F H + ++ Sbjct: 609 HSLTITRLKFS-KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP 667 Query: 171 LV-KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN---FNKDLFGT 226 L ++ S D TV +W + + H+ + H+ K L Sbjct: 668 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEA-SIKHTKAVTAISIHDSMIREKILISV 726 Query: 227 VSEDSLLKINDVRANNTTIDT-----VKCPQPFNTLAFSHHSSN---LLAAAGMDSYVYL 278 E+ + + + T + L +SH N L D + Sbjct: 727 GLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRI 786 Query: 279 YDLRN 283 Y L Sbjct: 787 YSLAY 791 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 46/317 (14%), Positives = 97/317 (30%), Gaps = 67/317 (21%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFL--YSRS----EGLQSTLKFHKDN---GYA 165 +++T + P ++AT Q T + + +T GY Sbjct: 386 SGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYD 445 Query: 166 L-SFSTLVKGRLLSGSDDHTVALWEVGSG--GDPTKPVRTWNDLHSDIINDNKW------ 216 + T+ R +SG D+ + +++ G G K V + S++ + Sbjct: 446 MICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLS 505 Query: 217 ------------------HNFNKDLFGTVS-------EDSLLK--INDVRANNTTIDTVK 249 + D+ +S ED L + + Sbjct: 506 NKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLW-----PEVEKLYG 560 Query: 250 CPQPFNTLAFSHHSSNLLAAAGM-----DSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFS 304 L S L+A+A ++ + ++ N E + H + L+FS Sbjct: 561 HGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFS 619 Query: 305 THVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNP-Q 363 ++S D + +W+ + + T + H + D D P + Sbjct: 620 K-DGKFLLSVCRDRKWALWE--RNMEDNTFELRFKNEKP-------HTRIIWDADWAPLE 669 Query: 364 IPWLVASAEEENILQVW 380 + +A + ++VW Sbjct: 670 FGNVFVTASRDKTVKVW 686 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 23/164 (14%), Positives = 55/164 (33%), Gaps = 15/164 (9%) Query: 206 LHSDIINDNKWHNFNKDLFGTVSEDS-----LLKINDVRANNTTIDTVK-CPQPFNTLAF 259 H I ++ L + + +++I + L F Sbjct: 560 GHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 618 Query: 260 SHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS-----GHEDAVNNLEFST-HVDGVVVS 313 S LL+ D L++ RNM++ + H + + +++ V V+ Sbjct: 619 SKDGKFLLSVC-RDRKWALWE-RNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 676 Query: 314 SGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVND 357 + D + +W ++ A+ +A + + + H S + + Sbjct: 677 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIRE 720 >6BX3-A nrPDB Length = 314 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 87/225 (38%), Gaps = 15/225 (6%) Query: 158 FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 ++ A G+ L+ + + ++++ +T H+ ++ W Sbjct: 8 GTQNGLKATCAKISPDGQFLAITQGLNILIYDIN----RRTVSQTLVTSHARPFSELCWS 63 Query: 218 NFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVY 277 + T S+D ++I + + + P +L F+ NLL + MD + Sbjct: 64 P-DGQCIATASDDFSVEIIHL-SYGLLHTFIGHTAPVISLTFN-RKGNLLFTSSMDESIK 120 Query: 278 LYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDA 337 ++D N + +S H +AV +++ + ++ S D + ++D + +T Sbjct: 121 IWDTLNGSL-MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYD 179 Query: 338 EDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 +D E +V ++ + +L+ + ++++W C Sbjct: 180 KDWKRENGVVP------ISQVKFSENARYLLVK-SLDGVVKIWDC 217 Score = 85.2 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 47/271 (17%), Positives = 93/271 (34%), Gaps = 27/271 (9%) Query: 122 TRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSD 181 T A+ P + T ++ +R Q+ + H L +S + + SD Sbjct: 16 TCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP-DGQCIATASD 74 Query: 182 DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRAN 241 D +V + + G + H+ + ++ LF + S D +KI D Sbjct: 75 DFSVEIIHLSYG------LLHTFIGHTAPVISLTFNRKGNLLFTS-SMDESIKIWDTLNG 127 Query: 242 NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDA---- 297 + + ++ + S++L++ D + ++D L ++ +D Sbjct: 128 SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET-GHCLKTLTYDKDWKREN 186 Query: 298 ----VNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 ++ ++FS ++ D + +WD +T L H S Sbjct: 187 GVVPISQVKFS-ENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVL------HHS 239 Query: 354 SVNDFDLNPQIPW--LVASAEEENILQVWKC 382 DF LNP+ LV S E + W Sbjct: 240 CGMDF-LNPEDGSTPLVISGYENGDIYCWNS 269 Score = 67.9 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 33/227 (14%), Positives = 76/227 (33%), Gaps = 25/227 (11%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGLQSTLKFHKDNGYALSFSTLVK 173 H + + + N++ T + ++ ++ + L T+ H + ++ Sbjct: 92 IGHTAPVISLTFN-RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS 150 Query: 174 GRLLSGSDDHTVALWEVGSGG--DPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 L SGS D + +++ +G + W + + + N S D Sbjct: 151 SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG 210 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHH-----------SSNLLAAAGMDSYVYLYD 280 ++KI D + T + QP H S+ L+ + + +Y ++ Sbjct: 211 VVKIWDC-IGGCVVRTFQV-QPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN 268 Query: 281 LRNMKEPLHHMSG----HEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 + K L + G H V ++ ++ S + +W Sbjct: 269 -SDTKSLLQLLDGSLYHHSSPVMSI---HCFGNIMCSLALNGDCCLW 311 >4U1E-I nrPDB Length = 347 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 55/330 (16%), Positives = 119/330 (36%), Gaps = 72/330 (21%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLY-SRSEGLQSTLKFHKDNGYALSFSTLVKG 174 HE +T+ +Y ++ +++ + + + ++ S + TL H +++ K Sbjct: 8 GHERPLTQVKYN-KEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTK- 65 Query: 175 RLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 ++GS D+++ LW+V +G + V TW + ++ + D+++K Sbjct: 66 YCVTGSADYSIKLWDVSNG----QCVATWKSP--VPVKRVEFSPCGNYFLAIL--DNVMK 117 Query: 235 ------INDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGM------------DSYV 276 I ++ ++ T + K + +H + AG D + Sbjct: 118 NPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKI 177 Query: 277 YLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK---------- 326 YD+ N E + + HE ++++++FS + + SS N ++ D+ Sbjct: 178 SKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLV-DVSTLQVLKKYET 236 Query: 327 ---------------------QIGAEQTPDDAEDGVPELIMVHA----------GHRSSV 355 Q + T A +G E H GH + Sbjct: 237 DCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPL 296 Query: 356 NDFDLNPQIPWLVASAEEENILQVWKCSHS 385 N ++PQ AS E+ +++ S Sbjct: 297 NTVAISPQGT-SYASGGEDGFIRLHHFEKS 325 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 47/238 (19%), Positives = 85/238 (35%), Gaps = 42/238 (17%) Query: 156 LKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNK 215 L H+ + ++ L S S D + ++W +G D H+ I Sbjct: 6 LTGHERPLTQVKYN-KEGDLLFSCSKDSSASVWYSLNGERLGTL-----DGHTGTIWSID 59 Query: 216 WHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS- 274 F K T S D +K+ DV T K P P + FS + LA +D+ Sbjct: 60 VDCFTKYCV-TGSADYSIKLWDVSNGQCVA-TWKSPVPVKRVEFSPCGNYFLAI--LDNV 115 Query: 275 -----YVYLYDLRN----------MKEPLHHMSGHE--DAVNNLEFSTHVDGVVVSSGSD 317 + +Y++ +EP+H + HE DA +ST +++ D Sbjct: 116 MKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKG-KYIIAGHKD 174 Query: 318 NRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEEN 375 ++ +D+ D H S++D +P + + + S+ + N Sbjct: 175 GKISKYDVSNNYEYVDSIDL-------------HEKSISDMQFSPDLTYFITSSRDTN 219 Score = 54.4 bits (129), Expect = 9e-08, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 34/90 (37%), Gaps = 3/90 (3%) Query: 244 TIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEF 303 I +P + ++ +LL + DS ++ N E L + GH + +++ Sbjct: 3 AIKLTGHERPLTQVKYN-KEGDLLFSCSKDSSASVWYSLN-GERLGTLDGHTGTIWSIDV 60 Query: 304 STHVDGVVVSSGSDNRLMMWDLKQIGAEQT 333 V+ +D + +WD+ T Sbjct: 61 D-CFTKYCVTGSADYSIKLWDVSNGQCVAT 89 >1NR0-A nrPDB Length = 611 Score = 84.5 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 47/323 (14%), Positives = 106/323 (32%), Gaps = 52/323 (16%) Query: 105 PRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG---LQSTLKFHKD 161 S EH + T A+ P A+ + G V ++ ++ L++T+ Sbjct: 46 VGSLTDTEIYTEHSHQTTVAKTSPS-GYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSG 104 Query: 162 NGYALSFSTLVKGRLLSGSDD---HTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN 218 +S+ + K G V L++ G+ + +N + Sbjct: 105 PVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNL-------TGQARAMNSVDFKP 157 Query: 219 FNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYL 278 + S+D+ + I + + + +++ ++ +L A+ G D + L Sbjct: 158 SRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDGTIVL 216 Query: 279 YD----LRNMKEPLHHMSG--HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQ 332 Y+ + + H +V L +S + S+ +D + +W++ + E+ Sbjct: 217 YNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKVEK 275 Query: 333 T------PDDAEDGV-----------------------PELIMVHAGHRSSVNDFDLNPQ 363 T +D + G+ + V GH ++ + Sbjct: 276 TIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSAD 335 Query: 364 IPWLVASAEEENILQVWKCSHSL 386 L SA+ E + W S + Sbjct: 336 GKTLF-SADAEGHINSWDISTGI 357 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 34/243 (13%), Positives = 85/243 (34%), Gaps = 17/243 (6%) Query: 142 TVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVR 201 TV + S ++ T H+ + ++ SG V +W+ T ++ Sbjct: 43 TVPVGSLTDTEIYTEHSHQTTV---AKTSPSGYYCASGDVHGNVRIWDTT---QTTHILK 96 Query: 202 TWNDLHSDIINDNKWHNFNKDLFGTV-SEDSLLKINDVRANNTTIDTVKCPQPFNTLAFS 260 T + S + D W + +K + + + + + + N++ F Sbjct: 97 TTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFK 156 Query: 261 HHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRL 320 + + D+ V +++ K H V+++ ++ + S+G D + Sbjct: 157 PSRPFRIISGSDDNTVAIFEGPPFKFKS-TFGEHTKFVHSVRYNP-DGSLFASTGGDGTI 214 Query: 321 MMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 ++++ +D + + H SV +P +ASA + +++W Sbjct: 215 VLYNGVDGTKTGVFEDDS-------LKNVAHSGSVFGLTWSPDGTK-IASASADKTIKIW 266 Query: 381 KCS 383 + Sbjct: 267 NVA 269 Score = 65.2 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 33/200 (16%), Positives = 74/200 (37%), Gaps = 21/200 (10%) Query: 133 IVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGS 192 +A + +YS + + + ++ + K + G D V ++++ Sbjct: 424 DIAVAACYKHIAIYSHGKLTEVPISYNSSCVAL----SNDKQFVAVGGQDSKVHVYKLSG 479 Query: 193 GGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI--NDVRANNTTIDTVK- 249 V+T +H I + N L T D K+ V N T Sbjct: 480 AS--VSEVKTI--VHPAEITSVAFSNNGAFLVAT---DQSRKVIPYSVANNFELAHTNSW 532 Query: 250 --CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG-HE-DAVNNLEFST 305 +++S + LA +D+ V ++++ + + G H +VN++ + Sbjct: 533 TFHTAKVACVSWSP-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW-- 589 Query: 306 HVDGVVVSSGSDNRLMMWDL 325 + +VS+G D+ + W++ Sbjct: 590 LNETTIVSAGQDSNIKFWNV 609 Score = 62.1 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 43/273 (15%), Positives = 88/273 (32%), Gaps = 25/273 (9%) Query: 113 AKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLV 172 +Y H + IT D + + + +G + + S G+ + + T Sbjct: 319 VRYGHNKAITALS-SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTS 377 Query: 173 KGRLLSGSDDHTVALWEVG-SGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 KG L + S D + + G SG D +K V + + + D+ Sbjct: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSA----DGDIAVAACYKH 433 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 + I + +A S+ +A G DS V++Y L Sbjct: 434 IA-IYSHGKLTEVPISYNSS----CVALSNDK-QFVAVGGQDSKVHVYKLSGASVSEVKT 487 Query: 292 SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 H + ++ FS + +V++ +++ + + + H Sbjct: 488 IVHPAEITSVAFS-NNGAFLVATDQSRKVIPYSVANNFELAHTNSWTF-----------H 535 Query: 352 RSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 + V +P L A+ +N + VW + Sbjct: 536 TAKVACVSWSPDNVRL-ATGSLDNSVIVWNMNK 567 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 26/200 (13%), Positives = 66/200 (33%), Gaps = 23/200 (11%) Query: 185 VALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTT 244 +++ V G + T + + + + + ++I D Sbjct: 39 TSVYTVPVGSLTDTEIYTEHSHQT----TVAKTSPSGYYCASGDVHGNVRIWDTTQTTHI 94 Query: 245 IDT--VKCPQPFNTLAFSHHSSNLLAAA-GMDSYVYLYDLRNMKEPLHHMSGHEDAVNNL 301 + T P +++ S + A G + + +++ L + +++G A+N++ Sbjct: 95 LKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVF-LFDTGTSNGNLTGQARAMNSV 153 Query: 302 EFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLN 361 +F ++S DN + ++ E + H V+ N Sbjct: 154 DFKPSRPFRIISGSDDNTVAIF--------------EGPPFKFKSTFGEHTKFVHSVRYN 199 Query: 362 PQIPWLVASAEEENILQVWK 381 P L AS + + ++ Sbjct: 200 PDGS-LFASTGGDGTIVLYN 218 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 25/165 (15%), Positives = 57/165 (34%), Gaps = 11/165 (6%) Query: 122 TRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLK--FHKDNGYALSFSTLVKGRLLSG 179 + + D VA V +Y S S +K H +++FS + + Sbjct: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT- 509 Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVR 239 D + + + H+ + W N L T S D+ + + ++ Sbjct: 510 --DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRL-ATGSLDNSVIVWNMN 566 Query: 240 --ANNTTIDTVKCPQP-FNTLAFSHHSSNLLAAAGMDSYVYLYDL 281 +++ I N++ + + + +AG DS + +++ Sbjct: 567 KPSDHPIIIKGAHAMSSVNSVIWL--NETTIVSAGQDSNIKFWNV 609 Score = 32.8 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 19/158 (12%), Positives = 44/158 (27%), Gaps = 32/158 (20%) Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHH-MSGHEDAV 298 + + S A+ + V ++D L + V Sbjct: 50 TDTEIYTEHSHQTTVAKTSPS---GYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPV 106 Query: 299 NNLEFSTHVDGVVVSSGSDNR---LMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSV 355 ++ + + + R + ++D T G ++ Sbjct: 107 KDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT----------------GQARAM 150 Query: 356 NDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPP 393 N D P P+ + S ++N + +++ GPP Sbjct: 151 NSVDFKPSRPFRIISGSDDNTVAIFE---------GPP 179 >1PI6-A nrPDB Length = 615 Score = 84.5 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 38/245 (15%), Positives = 75/245 (30%), Gaps = 15/245 (6%) Query: 95 GEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRS----E 150 G + + S + H + I P T+ G+V Y Sbjct: 137 GRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFS 196 Query: 151 GLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI 210 T + FS +++ D ++ ++ SG + I Sbjct: 197 ASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGI 256 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPF--NTLAFSHHSSNLLA 268 W + F TV D+ +++ DV + Q + + + Sbjct: 257 F-ALSW--LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII 313 Query: 269 AAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 + +D + Y+L E L +SGH + L + ++S D R+M W + Sbjct: 314 SLSLDGTLNFYEL-GHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWSSSSM 367 Query: 329 GAEQT 333 + + Sbjct: 368 HQDHS 372 Score = 76.8 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 41/249 (16%), Positives = 80/249 (32%), Gaps = 31/249 (12%) Query: 141 GTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPV 200 G + S + H A R ++ DD +V + G P K Sbjct: 142 GVFISWD-SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFY----QGPPFKFS 196 Query: 201 RTWNDLHS--DIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTT--IDTVKCPQPFNT 256 + H + D ++ + + TV D + D ++ I+ + P Sbjct: 197 ASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGI 256 Query: 257 LAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH--HMSGHEDAVNNLEFSTHVDGVVVSS 314 A S S A G D+ + ++D+ K + + + + +G ++S Sbjct: 257 FALSWLDSQKFATVGADATIRVWDVTTSK-CVQKWTLDKQQLGNQQVGVVATGNGRIISL 315 Query: 315 GSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEE 374 D L ++L G E++ +GH + +NP + S + Sbjct: 316 SLDGTLNFYEL--------------GHDEVLKTISGHNKGITALTVNP-----LISGSYD 356 Query: 375 NILQVWKCS 383 + W S Sbjct: 357 GRIMEWSSS 365 Score = 62.5 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 35/212 (16%), Positives = 78/212 (36%), Gaps = 30/212 (14%) Query: 134 VATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLS----------GSDDH 183 VA+ N G + + + L F D ++ ++ LS G+ Sbjct: 411 VASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQ 470 Query: 184 TVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANN- 242 L ++ D P+R S + ++ + + D+++ Sbjct: 471 VFKLSDLEVSFDLKTPLRAKPSYIS--------ISPSETYIAAGDVMGKILLYDLQSREV 522 Query: 243 TTIDTVKCPQPFNTLAFSHHS---------SNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 T N +++ +L+A +D+ +++Y ++ + + ++ Sbjct: 523 KTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA 582 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 H+D VNNL + T +VSSG+D + W++ Sbjct: 583 HKDGVNNLLWETP--STLVSSGADACIKRWNV 612 >3I2N-A nrPDB Length = 357 Score = 84.5 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 47/334 (14%), Positives = 109/334 (32%), Gaps = 28/334 (8%) Query: 71 NYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARY--MP 128 NY F +P G ++++ + E + I + Sbjct: 18 NYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATS 77 Query: 129 QDPNIVATINGQGTVFLYSRS--EGLQSTLKFHKDNGYALSFSTLVKGR-----LLSGSD 181 +AT + G + +++ E ++K HK+ A+ + +++GS Sbjct: 78 LQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSR 137 Query: 182 DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW---HNFNKDLFGTVSEDSLLKINDV 238 D TV +W+ DP + + + +N + + ++ +K+ D+ Sbjct: 138 DGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDL 197 Query: 239 RAN----NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNM----KEPLHH 290 R T I C F+ S + L+A ++ +++D+R Sbjct: 198 RNMALRWETNIKNGVCSLEFDRKDIS--MNKLVAT-SLEGKFHVFDMRTQHPTKGFASVS 254 Query: 291 MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL-----KQIGAEQTPDDAEDGVPELI 345 H+ V + + +++G L +W + + + G L+ Sbjct: 255 EKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLL 314 Query: 346 MVHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 ++ D +P L + + ++V Sbjct: 315 QNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 110/307 (35%), Gaps = 45/307 (14%) Query: 100 SSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATIN---GQGTVFLYSRSEGLQSTL 156 S+ P+ I + + + +++P V N G G + LY G L Sbjct: 2 SAFEKPQIIAHIQKGFNYT--VFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLL 59 Query: 157 KF--HKDNGYALSFS--TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIIN 212 + +F +L + L +G + +W + + P V+ H +IIN Sbjct: 60 REIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVK----GHKEIIN 115 Query: 213 DNKWHNFNKDL-----FGTVSEDSLLKINDVRANNTTI-----DTVKCPQPFNTLAFSHH 262 T S D +K+ D R + + + + T+AF + Sbjct: 116 AIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNA 175 Query: 263 SSN--LLAAAGMDS-YVYLYDLRNMKEPLHHMSGHED---AVNNLEFSTHVDGV--VVSS 314 + + AG D+ + L+DLRN + + V +LEF + +V++ Sbjct: 176 YNQEERVVCAGYDNGDIKLFDLRN-----MALRWETNIKNGVCSLEFDRKDISMNKLVAT 230 Query: 315 GSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEE 374 + + ++D++ Q P V E H+S+V PQ L +A Sbjct: 231 SLEGKFHVFDMR----TQHPTKGFASVSE-----KAHKSTVWQVRHLPQNRELFLTAGGA 281 Query: 375 NILQVWK 381 L +WK Sbjct: 282 GGLHLWK 288 >3JZG-A nrPDB Length = 402 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 44/245 (17%), Positives = 78/245 (31%), Gaps = 32/245 (13%) Query: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW-- 216 H G L F+T+ R V L+E S G+ + + W Sbjct: 65 HSKEGDPLVFATVGSNR---------VTLYECHSQGEIRLLQSYVDADADENFYTCAWTY 115 Query: 217 -HNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSY 275 N + L +++I + V N L F NLL + D Sbjct: 116 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 175 Query: 276 VYLYDLRNMKEPLHH--MSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQT 333 + L++++ + GH D V + ++ + ++ S G D+ L +W + Sbjct: 176 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM-SCGMDHSLKLWRINSKRMMNA 234 Query: 334 PDDAEDGVPELI--------------MVHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 ++ D P HR+ V+ + L+ S EN + Sbjct: 235 IKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW---LGDLILSKSCENAIVC 291 Query: 380 WKCSH 384 WK Sbjct: 292 WKPGK 296 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 42/261 (16%), Positives = 91/261 (34%), Gaps = 52/261 (19%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQ----STLKFHKDNGYAL 166 I H I ++ P+DPN++ +++ + L++ ++ H+D + Sbjct: 144 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA 203 Query: 167 SFSTLVKGRLLSGSDDHTVALWEVGS-----------------------GGDPTKPVRTW 203 + L+ +++S DH++ LW + S P + Sbjct: 204 DYD-LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFST 262 Query: 204 NDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHS 263 D+H + ++ +W DL + S ++ + ID +K + T+ Sbjct: 263 RDIHRNYVDCVRWL---GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDY 319 Query: 264 SN---------------LLAAAGMDSYVYLYDLR---NMKEPLHHMSGHE--DAVNNLEF 303 S +LA +Y++DL K ++ H+ A+ F Sbjct: 320 SQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSF 379 Query: 304 STHVDGVVVSSGSDNRLMMWD 324 S ++++ D + WD Sbjct: 380 S-RDSSILIAVCDDASIWRWD 399 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 31/229 (13%), Positives = 73/229 (31%), Gaps = 25/229 (10%) Query: 98 YQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPN--IVATINGQGTVFLYSR-SEGLQS 154 S R E T A + + ++A +G + + + + Sbjct: 86 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK 145 Query: 155 TLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDN 214 H + L F LLS S DH + LW + + D + + H D + Sbjct: 146 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT--DTLVAIFGGVEGHRDEVLSA 203 Query: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS 274 + + + + D LK+ + + + ++ + +N + Sbjct: 204 DY-DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD------YNPNKTNRPFIS---Q 253 Query: 275 YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 ++ D H + V+ + + + +++S +N ++ W Sbjct: 254 KIHFPDFSTRDI-------HRNYVDCVRW---LGDLILSKSCENAIVCW 292 >4E5Z-B nrPDB Length = 436 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 39/238 (16%), Positives = 85/238 (35%), Gaps = 17/238 (7%) Query: 147 SRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDL 206 LQ F +L++ + GS + LW G PT Sbjct: 107 DSYRILQKAAPF-DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 165 Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL 266 I K++ N + F S + ++ D + N + + +S+ Sbjct: 166 S---ITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSR 222 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK 326 + G D+ + L + L ++ H+ V ++ + D + ++ D + +WDL+ Sbjct: 223 MVVTG-DNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLR 281 Query: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 Q+ + + + HR VN +P L+ + ++++ ++V+ S Sbjct: 282 QVRGKAS-----------FLYSLPHRHPVNAACFSPDGARLL-TTDQKSEIRVYSASQ 327 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 43/282 (15%), Positives = 94/282 (33%), Gaps = 24/282 (8%) Query: 96 EEYQSSLPAPRSNIRITAKY-EHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQS 154 + Q S + RI K + T + P P+ VA + G + L++ + Sbjct: 96 QGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKP 155 Query: 155 TL---KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII 211 T + L F+ L + + S + T L + +R + + I Sbjct: 156 TFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGN-----ILRVFASSDTINI 210 Query: 212 --NDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 ++ + + +++ +N + + +A + LA Sbjct: 211 WFCSLDVSASSRMVVTGDNVGNVILLN--MDGKELWNLRMHKKKVTHVALNPCCDWFLAT 268 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSG--HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 A +D V ++DLR ++ + H VN FS ++++ + + ++ Q Sbjct: 269 ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP-DGARLLTTDQKSEIRVYSASQ 327 Query: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVA 369 D G+ H H + + +P+ +V Sbjct: 328 W-------DCPLGLIPHPHRHFQHLTPI-KAAWHPRYNLIVV 361 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 32/231 (13%), Positives = 69/231 (29%), Gaps = 38/231 (16%) Query: 186 ALWEVGSGGDPTKPVRTW-NDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTT 244 LW +G P R+ LH + W + + L + ++ + + Sbjct: 60 CLWVGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSF-------LHTLDSYRIL 112 Query: 245 IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS-GHEDAVNNLEF 303 + +LA+ + +A + L++ +P G ++ L+F Sbjct: 113 QKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKF 172 Query: 304 STHVDGVVVSSG-------------------SDNRLMMW----DLKQIGAEQTPDDAEDG 340 + +S S + + +W D+ D Sbjct: 173 NPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGN 232 Query: 341 V------PELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 V + + H+ V LNP W +A+A + +++W Sbjct: 233 VILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQV 283 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 30/211 (14%), Positives = 69/211 (32%), Gaps = 23/211 (10%) Query: 131 PNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEV 190 +V T + G V L + L+ HK ++ + L + S D TV +W++ Sbjct: 221 SRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 280 Query: 191 GSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKC 250 + + H +N + L T + S +++ + + + Sbjct: 281 RQVRGKASFLYSLP--HRHPVNAACFSPDGARLLTT-DQKSEIRVYSASQWDCPLGLIPH 337 Query: 251 PQ------PFNTLAFSHHSSNLLAAAGMDS-----------YVYLYDLRNMKEPLHHMSG 293 P A+ + ++ D + ++D + K Sbjct: 338 PHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDP 397 Query: 294 HEDAVNNL-EFSTHVDGVVVSSGSDNRLMMW 323 +++L EF+ D + + G +++W Sbjct: 398 ESSGISSLNEFNPMGDTLASAMGY--HILIW 426 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 25/182 (13%), Positives = 55/182 (30%), Gaps = 23/182 (12%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKF-----HKDNGYALSFSTL 171 H++++T P +AT + TV ++ ++ F H+ A FS Sbjct: 249 HKKKVTHVALNPCCDWFLATASVDQTVKIWDL-RQVRGKASFLYSLPHRHPVNAACFSP- 306 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII-NDNKWHNFNKDLFGTVSED 230 RLL+ + ++ P + + + WH + D Sbjct: 307 DGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPD 366 Query: 231 -----------SLLKINDVRANNTTIDTVK-CPQPFNTL-AFSHHSSNLLAAAGMDSYVY 277 + + D + ++L F+ L +A G ++ Sbjct: 367 PNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGY--HIL 424 Query: 278 LY 279 ++ Sbjct: 425 IW 426 >3EI3-B nrPDB Length = 383 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 31/214 (14%), Positives = 71/214 (33%), Gaps = 10/214 (4%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTL---KFHKDNGYALSFSTL 171 + +T + P P VA + G + L+ +++ D + F+ Sbjct: 70 SPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQF 129 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDS 231 +L S L + D + ++ + T + + Sbjct: 130 NTNQLFVSSIRGATTLRDFSGSVIQVFA----KTDSWDYWYCCVDVSVSRQMLATG-DST 184 Query: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM 291 + + F+ L+A + +D+ V L+DLRN+K+ ++ Sbjct: 185 GRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYI 244 Query: 292 SG--HEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 + HE VN F+ ++++ N + ++ Sbjct: 245 AEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVY 278 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 79/233 (33%), Gaps = 19/233 (8%) Query: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII 211 L T +L + + GS + LW+ + T ++ D I Sbjct: 65 LHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWD-YDVQNKTSFIQGMGPG--DAI 121 Query: 212 NDNKWHNFNKD--LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 K++ FN + ++ + L+ T + + S S +LA Sbjct: 122 TGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVS-VSRQMLAT 180 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG 329 DS L L + H+ V + EF+ D ++ +S D + +WDL+ I Sbjct: 181 G--DSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIK 238 Query: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 + + + H VN NP + + ++ N ++V+ Sbjct: 239 DKNSY-----------IAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSS 280 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 38/235 (16%), Positives = 83/235 (35%), Gaps = 23/235 (9%) Query: 107 SNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYAL 166 S I++ AK + + + ++AT + G + L K HK Sbjct: 151 SVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHA 210 Query: 167 SFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGT 226 F+ + + S D TV LW++ + D + H +N ++ + T Sbjct: 211 EFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMP--HEKPVNAAYFNPTDSTKLLT 268 Query: 227 VSEDSLLKI---NDVRANNTTI----DTVKCPQPFNTLAFSHHSSNLLAAAGMD------ 273 + + +++ D + I + P + ++A D Sbjct: 269 TDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKAT-WHPMYDLIVAGRYPDDQLLLN 327 Query: 274 --SYVYLYDLRNMKEPLHHMSG-HEDAVNNL-EFSTHVDGVVVSSGSDNRLMMWD 324 + +YD + +H + + + +L +FS D V++SG +++W+ Sbjct: 328 DKRTIDIYDANSGGL-VHQLRDPNAAGIISLNKFSPTGD--VLASGMGFNILIWN 379 Score = 34.8 bits (78), Expect = 0.067, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 47/142 (33%), Gaps = 19/142 (13%) Query: 101 SLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS------------- 147 L + A+ HE+ + A + P D + T + + + +YS Sbjct: 233 DLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIH 292 Query: 148 --RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWND 205 R + +K Y L + L +D T+ +++ SGG V D Sbjct: 293 PHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGG----LVHQLRD 348 Query: 206 LHSDIINDNKWHNFNKDLFGTV 227 ++ I + D+ + Sbjct: 349 PNAAGIISLNKFSPTGDVLASG 370 >5K0Y-T nrPDB Length = 329 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 45/322 (13%), Positives = 103/322 (31%), Gaps = 76/322 (23%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLY-SRSEGLQSTLKFHKDNGYAL--SFSTLV 172 HE IT+ +Y ++ +++ T+ V ++ S + T H + + + T Sbjct: 8 GHERSITQIKYN-REGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK- 65 Query: 173 KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSED-- 230 +L+GS D++ LW+ +G + L ++ +F ++ ++ Sbjct: 66 --HVLTGSADNSCRLWDCETG-------KQLALLKTNSAVRTCGFDFGGNIIMFSTDKQM 116 Query: 231 ---SLLKINDVR------ANNTTIDTVKCPQPFNTLAFSHHSSNLLA---AAGMDSYVYL 278 + D+R N + + + ++A + ++ Y Sbjct: 117 GYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSA- 175 Query: 279 YDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK------------ 326 E L ++ H +N+++ S + + V++ DN ++D Sbjct: 176 ----KSGEVLVNVKEHSRQINDIQLSREM-TMFVTASKDNTAKLFDSTTLEHQKTFRTEP 230 Query: 327 -------------------QIGAEQTPDDAEDGVPELIMVH----------AGHRSSVND 357 Q + T G E H GH +N Sbjct: 231 PRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINS 290 Query: 358 FDLNPQIPWLVASAEEENILQV 379 +P +S E+ +++ Sbjct: 291 VAFHPDGK-SYSSGGEDGYVRI 311 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 14/95 (14%), Positives = 36/95 (37%), Gaps = 16/95 (16%) Query: 288 LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMV 347 + GHE ++ ++++ D ++ + D + +W E + Sbjct: 3 PILLQGHERSITQIKYNREGD-LLFTVAKDPIVNVW--------------YSVNGERLGT 47 Query: 348 HAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 + GH +V D + ++ + +N ++W C Sbjct: 48 YMGHTGAVWCVDADWDTKHVL-TGSADNSCRLWDC 81 >6F1U-h nrPDB Length = 612 Score = 81.4 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 45/261 (17%), Positives = 79/261 (30%), Gaps = 33/261 (12%) Query: 118 EEEITRARYMPQDPNIVATINGQGTVFLYSRSEG----LQST---LKFHKDNGYAL-SFS 169 + + A + PN+V G + L+ +Q T H Y + Sbjct: 306 QSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVG 365 Query: 170 TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI-INDNKWHNFNKDLFGTVS 228 T L+S S D + W + P + + + + + + + F S Sbjct: 366 TQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGS 425 Query: 229 EDSLLKINDVRANNTTID------TVKCPQP---------FNTLAFSHHSSNLLAAAGMD 273 E+ + A P + FSH L + D Sbjct: 426 EEGSVYT----ACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSH----LFVTSSFD 477 Query: 274 SYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQT 333 V L+ +N K PL+ + V ++ +S + RL +W+L T Sbjct: 478 WTVKLWSTKNNK-PLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPT 536 Query: 334 PDDAEDGVPELIMVHAGHRSS 354 + +G P L V H Sbjct: 537 ASISVEGNPALNRVRWTHSGR 557 Score = 80.2 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 46/337 (13%), Positives = 102/337 (30%), Gaps = 45/337 (13%) Query: 92 EEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIV---------ATINGQGT 142 E+ E Q+ + ++ ++ + Q P ++ A G Sbjct: 227 EDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGV 286 Query: 143 VFLYS-RSEGLQSTLKFH-KDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGG-DPTKP 199 +++ + + FH + + +F+ ++ G+ + LW+ S P + Sbjct: 287 ALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQR 346 Query: 200 VRTWNDLHSDIINDNKWH-NFNKDLFGTVSEDSLLKINDV------RANNTTIDTVKCPQ 252 H+ + N ++S D + + + + + Sbjct: 347 TPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAV 406 Query: 253 PFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHM-SGHEDAVNNLEFSTHVD--- 308 +++F N + VY K + M GH+ + + V Sbjct: 407 AVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVD 466 Query: 309 --GVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPW 366 + V+S D + +W K + +D V D +P P Sbjct: 467 FSHLFVTSSFDWTVKLWSTKNNKPLYSFEDN--------------AGYVYDVMWSPTHPA 512 Query: 367 LVASAEEENILQVWKCSHSLPI------VGGPPKVNK 397 L A + L +W ++ + V G P +N+ Sbjct: 513 LFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNR 549 Score = 62.1 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 78/225 (34%), Gaps = 21/225 (9%) Query: 117 HEEEITRARYM-PQDPNIVATINGQGTVFLYSRS--EGLQSTLKF-HKDN----GYALSF 168 H + + Q+ + + +I+ G + +S Q +++ HK + ++SF Sbjct: 354 HTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSF 413 Query: 169 STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNF-----NKDL 223 + GS++ +V + + H I H L Sbjct: 414 PVGDVNNFVVGSEEGSVY---TACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHL 470 Query: 224 FGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN 283 F T S D +K+ + N + +S L A + L++L N Sbjct: 471 FVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNN 530 Query: 284 MKE---PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 E + G A+N + + TH + S+ +++++D+ Sbjct: 531 DTEVPTASISVEG-NPALNRVRW-THSGREIAVGDSEGQIVIYDV 573 >5WYJ-BE nrPDB Length = 939 Score = 81.0 bits (198), Expect = 9e-16, Method: Composition-based stats. Identities = 36/209 (17%), Positives = 73/209 (34%), Gaps = 15/209 (7%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQ-STLKFHKDNGYALSFSTLVKGR 175 + + M Q N + G++ +Y+ G+ K HK +S + + + Sbjct: 459 DDGFVKSVA-MSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNR-K 516 Query: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 ++S D V ++ K L D ++ + DLF +D + + Sbjct: 517 MVSCGLDGIVGFYDFNKSTLLGK-------LKLDAPITAMVYHRSSDLFALALDDLSIVV 569 Query: 236 NDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHE 295 D FS + +A +DS + +DL + + Sbjct: 570 IDAVTQRVVRQLWGHSNRITAFDFSP-EGRWIVSASLDSTIRTWDLPTGG-CIDGII--V 625 Query: 296 DAV-NNLEFSTHVDGVVVSSGSDNRLMMW 323 D V N++FS + D + + + N + +W Sbjct: 626 DNVATNVKFSPNGDLLATTHVTGNGICIW 654 Score = 75.6 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 56/421 (13%), Positives = 126/421 (29%), Gaps = 84/421 (19%) Query: 38 LTVQWLPTPVQELDGGFIKQELIIGTHTSG----EEENYLKFAEINLPKEILSNEDPQEE 93 T P + + + + +GT T + I +P+ +S+ + + Sbjct: 200 FTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIRTIKIPQSRISSLSFRTD 259 Query: 94 AGEEYQSSLPAP---------RSNIRITAKYEHEEE--ITRARYMPQDPNIVATINGQGT 142 + RS I + E +T+A ++ P I+ T G + Sbjct: 260 GSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQP-IIVTSGGDNS 318 Query: 143 VFLYSRSEGLQST-----------LK---FHKDNGYALSFSTLVKGRLLSGSDDHTVALW 188 + Y L L+ H ++F+ +LS S D + LW Sbjct: 319 LKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRS--LW 376 Query: 189 ------EVGSGGDPTKPVRTWNDL-------HSDIINDNKWHNFNK------DLFGTVSE 229 + S + + + S N ++ + Sbjct: 377 SFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKD 436 Query: 230 DSLLKINDVRANNTTIDTVKCPQP--FNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEP 287 + + D+R T ++A S + + + +Y++++ Sbjct: 437 EKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFI-GSSNGSITIYNMQSGILR 495 Query: 288 LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG------------------ 329 + H+ AV + ++ +VS G D + +D + Sbjct: 496 KKY-KLHKRAVTGISLD-GMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHR 553 Query: 330 ---------AEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 + + + ++ GH + + FD +P+ W+V SA ++ ++ W Sbjct: 554 SSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIV-SASLDSTIRTW 612 Query: 381 K 381 Sbjct: 613 D 613 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 46/271 (16%), Positives = 89/271 (32%), Gaps = 43/271 (15%) Query: 128 PQDPNIVATINGQGTVFLYS------RSEGLQSTLKFHKDNGYALSFSTLVKGRLLS--- 178 + P IVA + + + E T +F T G + S Sbjct: 409 SKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAM 468 Query: 179 ---------GSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 GS + ++ ++ + SG +R LH + N+ + + Sbjct: 469 SQCGNFGFIGSSNGSITIYNMQSG-----ILRKKYKLHKRAVTGISLDGMNRKMV-SCGL 522 Query: 230 DSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH 289 D ++ D +T + +K P + + H SS+L A A D + + D + + Sbjct: 523 DGIVGFYDF-NKSTLLGKLKLDAPITAMVY-HRSSDLFALALDDLSIVVIDAVTQRV-VR 579 Query: 290 HMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 + GH + + +FS +VS+ D+ + WDL G Sbjct: 580 QLWGHSNRITAFDFSPEG-RWIVSASLDSTIRTWDLPTGGCIDGIIV------------- 625 Query: 350 GHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 + + +P L + N + +W Sbjct: 626 --DNVATNVKFSPNGDLLATTHVTGNGICIW 654 >5A9Q-2 nrPDB Length = 326 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 88/277 (31%), Gaps = 34/277 (12%) Query: 115 YEHEEEITRARYMPQD-----PNIVATINGQGTVFLYSRSEGLQ-----STLKFHKDNGY 164 + H + + P+ P ++ + + + LQ L+ H D Sbjct: 69 FHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFIN 128 Query: 165 ALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLF 224 L F + S SDDHT +W + V+T + + WH Sbjct: 129 GLVFDPKEGQEIASVSDDHTCRIWNLEG-------VQTAHFVLHSPGMSVCWHPEETFKL 181 Query: 225 GTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLL-AAAGMDSYVYLYDLRN 283 ++ ++ D+ A + P + + ++ + A AG D + +D+ Sbjct: 182 MVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLI--WDITR 239 Query: 284 MKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPE 343 P + H D +ST + + ++G G P+ Sbjct: 240 SSYPQNKRPVHMDRACLFRWSTISENLFATTGY----------PGKMASQFQIHHLGHPQ 289 Query: 344 LIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 I++ G + + + +P + ++ L W Sbjct: 290 PILM--GSVAVGSGLSWHRTLP--LCVIGGDHKLLFW 322 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 29/243 (11%), Positives = 78/243 (32%), Gaps = 35/243 (14%) Query: 160 KDNGYALSFSTLVKG----RLLSGSDDHTV---ALWEVGSGGDPTKPVRTWND-LHSDII 211 +D + + F+ G + G +++ V ++ +T H + Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRV 75 Query: 212 NDNKWHNFNK-------DLFGTVSEDSLLKIN--DVRANNTTIDTVKCPQPFNTLAFSHH 262 + W + F T + D +++ D++ N N L F Sbjct: 76 DGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPK 135 Query: 263 SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMM 322 +A+ D +++L ++ + H + ++ + ++ + + + Sbjct: 136 EGQEIASVSDDHTCRIWNLEGVQTAHFVL--HSPGM-SVCWHPEETFKLMVAEKNGTIRF 192 Query: 323 WDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 +DL A + + E + + + H + + V + + L +W Sbjct: 193 YDLLAQQAILSLE------SEQVPLMSAH--------WCLKNTFKVGAVAGNDWL-IWDI 237 Query: 383 SHS 385 + S Sbjct: 238 TRS 240 Score = 69.1 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 30/221 (13%), Positives = 77/221 (34%), Gaps = 11/221 (4%) Query: 105 PRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGY 164 + H + I + P++ +A+++ T +++ + H G Sbjct: 111 LQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHS-PGM 169 Query: 165 ALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLF 224 ++ + +L+ + T+ +++ + + + + + W N Sbjct: 170 SVCWHPEETFKLMVAEKNGTIRFYDLLAQ----QAILSLESEQ-VPLMSAHWCLKNTFKV 224 Query: 225 GTVSEDSLLKINDV-RANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYL-YDLR 282 G V+ + I D+ R++ +S S NL A G + + + Sbjct: 225 GAVAG-NDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIH 283 Query: 283 NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 ++ P + G + L + + + V G D++L+ W Sbjct: 284 HLGHPQPILMGSVAVGSGLSWHRTL-PLCVIGG-DHKLLFW 322 >3ACP-A nrPDB Length = 417 Score = 80.2 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 50/273 (18%), Positives = 104/273 (38%), Gaps = 32/273 (11%) Query: 99 QSSLPAPRSNIRITAKYE--HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQ-ST 155 + + SN + + + H EIT+ ++ P + + + + ++S +G T Sbjct: 115 EGDIKVLDSNFNLQREIDQAHVSEITKLKFFPS-GEALISSSQDMQLKIWSVKDGSNPRT 173 Query: 156 LKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNK 215 L H+ ++ + L S S D T+ LWE G+G R N D +N Sbjct: 174 LIGHRATVTDIAIIDRGRNVL-SASLDGTIRLWECGTGTTIHTFNRKENPH--DGVNSIA 230 Query: 216 -WHNFNKDLFGTVSEDS-------------------LLKINDVRANNTTIDTV-KCPQPF 254 + ++ L + ++ +++V + TI K Sbjct: 231 LFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSC 290 Query: 255 NTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPL-HHMSGHEDAVNNLEFSTHVDGVVVS 313 N+L +++N + A + + +DLR+ + P+ + +NN+ F+ + VS Sbjct: 291 NSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFA--AGALFVS 348 Query: 314 SGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIM 346 SG D + + D+ + P + L+ Sbjct: 349 SGFDTSIKL-DIISDPESERPAIEFETPTFLVS 380 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 35/233 (15%), Positives = 77/233 (33%), Gaps = 31/233 (13%) Query: 134 VATINGQGTVFLYSRSEGLQSTL-KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGS 192 +G + + + LQ + + H L F + L+S S D + +W V Sbjct: 109 FILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEA-LISSSQDMQLKIWSVKD 167 Query: 193 GGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQ 252 G +P + H + D + +++ + S D +++ + T + Sbjct: 168 GSNPRTLI-----GHRATVTDIAIIDRGRNVL-SASLDGTIRLWECGTGTTIHTFNRKEN 221 Query: 253 P---FNTLA-----------FSHHSSNLLAAAGMDSY---------VYLYDLRNMKEPLH 289 P N++A S N L Y + ++++ + ++ + Sbjct: 222 PHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQ 281 Query: 290 HMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVP 342 S + N+L + + + + L WDL+ +G P Sbjct: 282 LPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTP 334 Score = 56.0 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 22/117 (18%), Positives = 46/117 (39%), Gaps = 17/117 (14%) Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 + + + D N H + L+F + ++ SS D +L +W + Sbjct: 108 RFILGTTEGDIKVLD-SNFNLQREIDQAHVSEITKLKFFPSGEALI-SSSQDMQLKIWSV 165 Query: 326 KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 K DG ++ GHR++V D + + ++ SA + +++W+C Sbjct: 166 K------------DGSNPRTLI--GHRATVTDIAIIDRGRNVL-SASLDGTIRLWEC 207 >3F3P-A nrPDB Length = 351 Score = 78.3 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 44/296 (14%), Positives = 98/296 (33%), Gaps = 40/296 (13%) Query: 117 HEEEITRARY-MPQDPNIVATINGQGTVFLYSRSEGLQS----------TLKFHKDNGYA 165 H+ I + P+ I+A+ + TV L+ + TL K + Y+ Sbjct: 56 HDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYS 115 Query: 166 LSFSTLVKG-RLLSGSDDHTVALWEVGSGGDPT--------KPVRTWNDLHSDIINDNKW 216 + F+ G +L +D + L++ D K + H W Sbjct: 116 VKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSW 175 Query: 217 HN--FNKDLFGTVSEDSLLKINDVRANN--TTIDTVKCPQPFNTLAFSHHSS---NLLAA 269 F+ + + + + + +++++ L+A Sbjct: 176 CPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIAT 235 Query: 270 AGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIG 329 D + ++ + E L ++ E N+ F D + + G + Sbjct: 236 GCKDGRIRIFKI---TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS---------N 283 Query: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 E+ + + EL+ H H V N +++SA ++ +++WK ++S Sbjct: 284 TEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLWKATYS 338 Score = 75.2 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 38/264 (14%), Positives = 83/264 (31%), Gaps = 42/264 (15%) Query: 151 GLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI 210 +Q H D + + + + + S D + ++++ + +W S I Sbjct: 2 HMQPFDSGHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSI 60 Query: 211 INDNKWHNFNKDLFGTVSEDSLLKIND---------VRANNTTIDTVKCPQPFNTLAFSH 261 + + + + S D +K+ + R N ++ F+ Sbjct: 61 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 120 Query: 262 -HSSNLLAAAGMDSYVYLYD-LRNMKEPLHHMS-----------GHEDAVNNLEFST--- 305 H LA G D + LYD L ++ H + L + Sbjct: 121 AHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF 180 Query: 306 HVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIP 365 + + VS+ + +DG + GH+S + P I Sbjct: 181 SPEKLAVSA-------------LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIG 227 Query: 366 W---LVASAEEENILQVWKCSHSL 386 L+A+ ++ ++++K + L Sbjct: 228 RWYQLIATGCKDGRIRIFKITEKL 251 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 21/180 (11%), Positives = 66/180 (36%), Gaps = 13/180 (7%) Query: 116 EHEEEITRARYMPQ--DPNIVATINGQGTVFLYSRSE----GLQSTLKFHKDNGYALSFS 169 H + + P P +A + + +Y R + + + L HK ++S++ Sbjct: 165 NHLQSDFCLSWCPSRFSPEKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWA 223 Query: 170 TLVK---GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGT 226 + + +G D + ++++ P + + S++ +++ + + Sbjct: 224 PSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTN--SNMFDNSADVDMDAQGRSD 281 Query: 227 VSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE 286 + + ++ + +++++ + +L++AG D V L+ E Sbjct: 282 SNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWN-LTGTILSSAGDDGKVRLWKATYSNE 340 >5BJS-A nrPDB Length = 605 Score = 76.8 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 39/263 (14%), Positives = 85/263 (32%), Gaps = 43/263 (16%) Query: 110 RITAKYEHEE-EITRARYMPQDP----NIVATINGQGTVFLYSRSEG-LQSTLKFHKDNG 163 I + E A +DP ++ +G V +Y+ +EG L TL H Sbjct: 122 EIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGI 181 Query: 164 YALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWND-LHSDIINDNKWHNFNKD 222 L+ S + S SDD T+ +W + + V HS + +H+ + Sbjct: 182 NDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRY 241 Query: 223 LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLR 282 + + D ++ + + + + + H S+ Sbjct: 242 VL-SAGHDQVINLWAL------PEFPNEHMEIPIVIYYPHFSS----------------- 277 Query: 283 NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVP 342 H + V+ + F + D ++ + ++ +++W ++ ++ D Sbjct: 278 --------SEIHNNLVDCVAF--YGDLILSRACHEDTIVLWRIEGFSSDDPIPGPLDAPT 327 Query: 343 ELIMVHAGHRSSVNDFDLNPQIP 365 M S ++PQ Sbjct: 328 PTDMTKQ--TRSYFTPTVSPQSR 348 Score = 67.9 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 36/198 (18%), Positives = 69/198 (34%), Gaps = 31/198 (15%) Query: 213 DNKWHNFNKD----LFGTVSED-----SLLKINDVRANNTTI-----DTVKCPQPFNTLA 258 D K++ ++ +F S+ L + D AN I D + + Sbjct: 82 DVKFYPYSPPGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCASCWS 141 Query: 259 FSH-HSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSD 317 LL AG + V +Y++ K + GH +N+L S ++ S+ D Sbjct: 142 KDPITDQPLLCIAGNEGNVKVYNVTEGKL-YRTLVGHGGGINDLATSPANPYIIASASDD 200 Query: 318 NRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENIL 377 + +W L +Q I+ GH + + +++ SA + ++ Sbjct: 201 TTIRIWSLAPEHEKQ--------PCVCILGGEGHSYDLLSVAFHDNGRYVL-SAGHDQVI 251 Query: 378 QVWKCSH------SLPIV 389 +W +PIV Sbjct: 252 NLWALPEFPNEHMEIPIV 269 >5MWJ-A nrPDB Length = 337 Score = 75.6 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 43/279 (15%), Positives = 88/279 (31%), Gaps = 47/279 (16%) Query: 115 YEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYAL-SFST--- 170 H E+ A + +P G+G V ++ S +K L + Sbjct: 48 LNH-GEVVCAVTI-SNPTRHVYTGGKGCVKVWDISH------PGNKSPVSQLDCLNRDNY 99 Query: 171 -------LVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDL 223 L+ G + T+++W++ + PT ++ + +K Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAA---PTPRIKAELTSSAPACYALAISPDSKVC 156 Query: 224 FGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN 283 F + D + + D+ + + S+ + L G+D+ V +DLR Sbjct: 157 F-SCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLW-TGGLDNTVRSWDLRE 214 Query: 284 MKEPLHHMSGH--EDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGV 341 ++ + H + +L + + + V S N + Sbjct: 215 GRQ----LQQHDFTSQIFSLGYCPTGEWLAVGMESSN---------------VEVLHVNK 255 Query: 342 PELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 P+ +H H S V W S ++N+L W Sbjct: 256 PDKYQLHL-HESCVLSLKFAYCGKW-FVSTGKDNLLNAW 292 >6CB1-s nrPDB Length = 569 Score = 71.8 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 41/178 (23%), Positives = 70/178 (39%), Gaps = 20/178 (11%) Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 II D K+H F LF V ++I D+ + + + + NL+A+ Sbjct: 403 IIMDAKFHPFKPQLF--VCSQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS 460 Query: 270 AGMDSYVYLY-DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 D V L+ DL P + HE AV ++ F + + S+ D + ++ Sbjct: 461 -SFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKL-PLFSSAADDGTIHVF----- 512 Query: 329 GAEQTPDDAEDGVPELIMVHA--GHRS----SVNDFDLNPQIPWLVASAEEENILQVW 380 T D P ++ + GH+ V D +P+ WL SA +N ++W Sbjct: 513 --HATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLF-SAGADNTARLW 567 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 37/232 (15%), Positives = 88/232 (37%), Gaps = 30/232 (12%) Query: 110 RITAKYEHEEEITRARYMPQDPNIVATI---NGQGTVFLYSRSEGL-QSTLKFHKDNGYA 165 I ++ + + + + + T+ +G +V ++ S+ L QS K K Sbjct: 348 DICITISCKKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMD 406 Query: 166 LSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFG 225 F + V ++++ K + + ++ H +L Sbjct: 407 AKFHPFKPQLFVCS--QRYVRIYDLSQQILVKKLLPG-----ARWLSKIDIHPRGDNLIA 459 Query: 226 TVSEDSLLKINDVRANNTTIDTVK-CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD---- 280 + S D + +D+ +T T++ + ++ F H L ++A D ++++ Sbjct: 460 S-SFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNF-HKKLPLFSSAADDGTIHVFHATVY 517 Query: 281 ---LRNMK-EPLHHMSGHEDAVNNL-----EFSTHVDGVVVSSGSDNRLMMW 323 ++N PL ++GH +N+L + + + S+G+DN +W Sbjct: 518 DDMMKNPMIVPLKKLTGH-KVINSLGVLDAIWHPR-EAWLFSAGADNTARLW 567 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 38/260 (14%), Positives = 77/260 (29%), Gaps = 42/260 (16%) Query: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI- 210 + HK LS L +GSDD TV +WE+ +G + + ++ + D Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGL-WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 249 Query: 211 INDNKWHN-FNKDLFGTVSEDSLLKI------NDVRANNTTIDTVKC-PQPFNTLAFSHH 262 I +W+ N + +++ I D+ N T F T+ S+ Sbjct: 250 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 309 Query: 263 SSNLLAAAGMD-----------SYVYLYDLRNMKE-----PLHHMSGHEDAVNNLEFSTH 306 N D V ++ + K+ + + V L + Sbjct: 310 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISC--KKTVKKLSWHRK 367 Query: 307 VDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPW 366 D V ++ + + + + D +P P Sbjct: 368 GDYFVT------------VQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 415 Query: 367 LVASAEEENILQVWKCSHSL 386 L + ++++ S + Sbjct: 416 LFV--CSQRYVRIYDLSQQI 433 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 25/55 (45%), Gaps = 1/55 (1%) Query: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 I +P D ++AGH+ V ++P WL A+ ++ ++VW+ Sbjct: 175 IPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWL-ATGSDDGTVRVWEI 228 Score = 41.3 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 42/339 (12%), Positives = 99/339 (29%), Gaps = 83/339 (24%) Query: 112 TAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS--RSEGLQSTLKFHKDN-----GY 164 T H+ ++ P +AT + GTV ++ + T + Sbjct: 193 TIYAGHKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIE 251 Query: 165 ALSFSTLVKGRLLSGSDDHTVAL-------WEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 + ++ +L+ + + L +++ + G + + D K Sbjct: 252 CIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKT----KIEDGFGYDTFGTVKKS 307 Query: 218 NFNKDLFGTVSED-----------SLLKINDVRANNT----TIDTVKCPQPFNTLAFSHH 262 N + G ED + + + T+ C + L++ H Sbjct: 308 NLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSW-HR 366 Query: 263 SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH---------EDAVNNLEFSTHVDGVVVS 313 + DS N +H +S H + + + +F + V Sbjct: 367 KGDYFVTVQPDS-------GNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVC 419 Query: 314 SGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG----------------------- 350 S + ++DL Q + + ++ + G Sbjct: 420 S--QRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTP 477 Query: 351 ------HRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 H +V + + ++P L +SA ++ + V+ + Sbjct: 478 YKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHAT 515 >6C0F-s nrPDB Length = 807 Score = 71.8 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 41/178 (23%), Positives = 70/178 (39%), Gaps = 20/178 (11%) Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 II D K+H F LF V ++I D+ + + + + NL+A+ Sbjct: 641 IIMDAKFHPFKPQLF--VCSQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS 698 Query: 270 AGMDSYVYLY-DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 D V L+ DL P + HE AV ++ F + + S+ D + ++ Sbjct: 699 -SFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKL-PLFSSAADDGTIHVF----- 750 Query: 329 GAEQTPDDAEDGVPELIMVHA--GHRS----SVNDFDLNPQIPWLVASAEEENILQVW 380 T D P ++ + GH+ V D +P+ WL SA +N ++W Sbjct: 751 --HATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLF-SAGADNTARLW 805 Score = 67.9 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 37/232 (15%), Positives = 88/232 (37%), Gaps = 30/232 (12%) Query: 110 RITAKYEHEEEITRARYMPQDPNIVATI---NGQGTVFLYSRSEGL-QSTLKFHKDNGYA 165 I ++ + + + + + T+ +G +V ++ S+ L QS K K Sbjct: 586 DICITISCKKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMD 644 Query: 166 LSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFG 225 F + V ++++ K + + ++ H +L Sbjct: 645 AKFHPFKPQLFVCS--QRYVRIYDLSQQILVKKLLPG-----ARWLSKIDIHPRGDNLIA 697 Query: 226 TVSEDSLLKINDVRANNTTIDTVK-CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD---- 280 + S D + +D+ +T T++ + ++ F H L ++A D ++++ Sbjct: 698 S-SFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNF-HKKLPLFSSAADDGTIHVFHATVY 755 Query: 281 ---LRNMK-EPLHHMSGHEDAVNNL-----EFSTHVDGVVVSSGSDNRLMMW 323 ++N PL ++GH +N+L + + + S+G+DN +W Sbjct: 756 DDMMKNPMIVPLKKLTGH-KVINSLGVLDAIWHPR-EAWLFSAGADNTARLW 805 Score = 51.0 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 38/260 (14%), Positives = 77/260 (29%), Gaps = 42/260 (16%) Query: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI- 210 + HK LS L +GSDD TV +WE+ +G + + ++ + D Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGL-WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 211 INDNKWHN-FNKDLFGTVSEDSLLKI------NDVRANNTTIDTVKC-PQPFNTLAFSHH 262 I +W+ N + +++ I D+ N T F T+ S+ Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 263 SSNLLAAAGMD-----------SYVYLYDLRNMKE-----PLHHMSGHEDAVNNLEFSTH 306 N D V ++ + K+ + + V L + Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISC--KKTVKKLSWHRK 605 Query: 307 VDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPW 366 D V ++ + + + + D +P P Sbjct: 606 GDYFVT------------VQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 653 Query: 367 LVASAEEENILQVWKCSHSL 386 L + ++++ S + Sbjct: 654 LFV--CSQRYVRIYDLSQQI 671 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 25/55 (45%), Gaps = 1/55 (1%) Query: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 I +P D ++AGH+ V ++P WL A+ ++ ++VW+ Sbjct: 413 IPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWL-ATGSDDGTVRVWEI 466 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 42/339 (12%), Positives = 99/339 (29%), Gaps = 83/339 (24%) Query: 112 TAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS--RSEGLQSTLKFHKDN-----GY 164 T H+ ++ P +AT + GTV ++ + T + Sbjct: 431 TIYAGHKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIE 489 Query: 165 ALSFSTLVKGRLLSGSDDHTVAL-------WEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 + ++ +L+ + + L +++ + G + + D K Sbjct: 490 CIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKT----KIEDGFGYDTFGTVKKS 545 Query: 218 NFNKDLFGTVSED-----------SLLKINDVRANNT----TIDTVKCPQPFNTLAFSHH 262 N + G ED + + + T+ C + L++ H Sbjct: 546 NLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSW-HR 604 Query: 263 SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH---------EDAVNNLEFSTHVDGVVVS 313 + DS N +H +S H + + + +F + V Sbjct: 605 KGDYFVTVQPDS-------GNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVC 657 Query: 314 SGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG----------------------- 350 S + ++DL Q + + ++ + G Sbjct: 658 S--QRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTP 715 Query: 351 ------HRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 H +V + + ++P L +SA ++ + V+ + Sbjct: 716 YKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHAT 753 >4OWR-A nrPDB Length = 339 Score = 71.4 bits (173), Expect = 7e-13, Method: Composition-based stats. Identities = 47/318 (14%), Positives = 86/318 (27%), Gaps = 73/318 (22%) Query: 109 IRITAKYEHEEEITRARYMPQD--PNIVATINGQGTVFLYSRSEGLQSTLKF---HKDNG 163 + I ++ I + P N + + V + + Q+ K H Sbjct: 1 MDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPV 60 Query: 164 YALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN-FNKD 222 + +S ++ + S D T +W++ S H + W N Sbjct: 61 LDVCWSD-DGSKVFTASCDKTAKMWDLSSNQAIQI------AQHDAPVKTIHWIKAPNYS 113 Query: 223 LFGTVSEDSLLKINDVRANNT------------------------------TIDTVKCPQ 252 T S D LK D R++N P Sbjct: 114 CVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPS 173 Query: 253 PFNTLA--FSHHSSNL------------LAAAGMDSYVYL--YDLRNMKEPLHHMSGHED 296 F + H + A ++ V + + N + H Sbjct: 174 EFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRS 233 Query: 297 A------------VNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 VN + F V G + + GSD R WD +T + + + Sbjct: 234 NGTNTSAPQDIYAVNGIAFHP-VHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISAC 292 Query: 345 IMVHAGHR-SSVNDFDLN 361 H G+ + + +D + Sbjct: 293 CFNHNGNIFAYASSYDWS 310 >6EM1-m nrPDB Length = 807 Score = 71.0 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 41/178 (23%), Positives = 70/178 (39%), Gaps = 20/178 (11%) Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAA 269 II D K+H F LF V ++I D+ + + + + NL+A+ Sbjct: 641 IIMDAKFHPFKPQLF--VCSQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS 698 Query: 270 AGMDSYVYLY-DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 D V L+ DL P + HE AV ++ F + + S+ D + ++ Sbjct: 699 -SFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKL-PLFSSAADDGTIHVF----- 750 Query: 329 GAEQTPDDAEDGVPELIMVHA--GHRS----SVNDFDLNPQIPWLVASAEEENILQVW 380 T D P ++ + GH+ V D +P+ WL SA +N ++W Sbjct: 751 --HATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLF-SAGADNTARLW 805 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 37/232 (15%), Positives = 88/232 (37%), Gaps = 30/232 (12%) Query: 110 RITAKYEHEEEITRARYMPQDPNIVATI---NGQGTVFLYSRSEGL-QSTLKFHKDNGYA 165 I ++ + + + + + T+ +G +V ++ S+ L QS K K Sbjct: 586 DICITISCKKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMD 644 Query: 166 LSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFG 225 F + V ++++ K + + ++ H +L Sbjct: 645 AKFHPFKPQLFVCS--QRYVRIYDLSQQILVKKLLPG-----ARWLSKIDIHPRGDNLIA 697 Query: 226 TVSEDSLLKINDVRANNTTIDTVK-CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD---- 280 + S D + +D+ +T T++ + ++ F H L ++A D ++++ Sbjct: 698 S-SFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNF-HKKLPLFSSAADDGTIHVFHATVY 755 Query: 281 ---LRNMK-EPLHHMSGHEDAVNNL-----EFSTHVDGVVVSSGSDNRLMMW 323 ++N PL ++GH +N+L + + + S+G+DN +W Sbjct: 756 DDMMKNPMIVPLKKLTGH-KVINSLGVLDAIWHPR-EAWLFSAGADNTARLW 805 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 39/258 (15%), Positives = 78/258 (30%), Gaps = 38/258 (14%) Query: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI- 210 + HK LS L +GSDD TV +WE+ +G + + ++ + D Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGL-WLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 211 INDNKWHN-FNKDLFGTVSEDSLLKI------NDVRANNTTIDTVKC-PQPFNTLAFSHH 262 I +W+ N + +++ I D+ N T F T+ S+ Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 263 SSNLLAAAGMD-----------SYVYLYDLRNMK--EPLHHMS-GHEDAVNNLEFSTHVD 308 N D V ++ + K E ++ + V L + D Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 607 Query: 309 GVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLV 368 V ++ + + + + D +P P L Sbjct: 608 YFVT------------VQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLF 655 Query: 369 ASAEEENILQVWKCSHSL 386 + ++++ S + Sbjct: 656 V--CSQRYVRIYDLSQQI 671 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 25/55 (45%), Gaps = 1/55 (1%) Query: 328 IGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 I +P D ++AGH+ V ++P WL A+ ++ ++VW+ Sbjct: 413 IPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWL-ATGSDDGTVRVWEI 466 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 42/339 (12%), Positives = 99/339 (29%), Gaps = 83/339 (24%) Query: 112 TAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS--RSEGLQSTLKFHKDN-----GY 164 T H+ ++ P +AT + GTV ++ + T + Sbjct: 431 TIYAGHKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIE 489 Query: 165 ALSFSTLVKGRLLSGSDDHTVAL-------WEVGSGGDPTKPVRTWNDLHSDIINDNKWH 217 + ++ +L+ + + L +++ + G + + D K Sbjct: 490 CIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKT----KIEDGFGYDTFGTVKKS 545 Query: 218 NFNKDLFGTVSED-----------SLLKINDVRANNT----TIDTVKCPQPFNTLAFSHH 262 N + G ED + + + T+ C + L++ H Sbjct: 546 NLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSW-HR 604 Query: 263 SSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH---------EDAVNNLEFSTHVDGVVVS 313 + DS N +H +S H + + + +F + V Sbjct: 605 KGDYFVTVQPDS-------GNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVC 657 Query: 314 SGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG----------------------- 350 S + ++DL Q + + ++ + G Sbjct: 658 S--QRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTP 715 Query: 351 ------HRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 H +V + + ++P L +SA ++ + V+ + Sbjct: 716 YKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHAT 753 >5CXB-B nrPDB Length = 369 Score = 69.4 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 29/170 (17%), Positives = 58/170 (34%), Gaps = 15/170 (8%) Query: 216 WHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSY 275 +H F V+ ++ D++ + ++ + L D Sbjct: 209 FHPLRPLFF--VATQRSIRCYDLQKLELVKIVQPGAKWISSFDVHP-GGDNLVVGSYDKR 265 Query: 276 VYLY-DLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTP 334 + L+ DL P M H +A+ + F + + D L ++ + Sbjct: 266 L-LWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIF-----HGKVPN 319 Query: 335 DDAEDGVPELIMVHAGHRS----SVNDFDLNPQIPWLVASAEEENILQVW 380 D E+ + + GH+ V D D +P+ PW SA + ++W Sbjct: 320 DQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPW-CVSAGADGTARLW 368 Score = 54.8 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 84/278 (30%), Gaps = 29/278 (10%) Query: 112 TAKYEHEEEITRARYMPQDPNIVATINGQGTVFLY-----SRSEGLQSTLKFHKDNGYAL 166 + K +E + R+ P + +FL S + L + + G+ Sbjct: 58 SVKLNGDEAVNTVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGH 117 Query: 167 SFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGT 226 + + + L G + W G I WH D F T Sbjct: 118 ATNGKQQANLPPGKEPP--GKW-ARPGTRLEDEGVLLRITVRSTIKAISWHRR-GDHFAT 173 Query: 227 VSEDS---LLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRN 283 VS + I+ + + T I K T +F L A + YDL+ Sbjct: 174 VSPSGQRSSVAIHTLSKHLTQIPFRKLNGLAQTASFHP-LRPLFFVATQ-RSIRCYDLQK 231 Query: 284 MKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPE 343 ++ G +++ + D +VV D RL+ DL D Sbjct: 232 LELVKIVQPG-AKWISSFDVHPGGDNLVV-GSYDKRLLWHDL-------------DLSNR 276 Query: 344 LIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 H ++ + L A A ++ LQ++ Sbjct: 277 PYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFH 314 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 11/74 (14%), Positives = 27/74 (36%), Gaps = 1/74 (1%) Query: 243 TTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLE 302 ++A LA G D V +++L ++ ++AVN + Sbjct: 13 QQTIFRGHEGRVRSVAIDPT-GVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVR 71 Query: 303 FSTHVDGVVVSSGS 316 + D ++++ + Sbjct: 72 WRPTKDTFILAAAA 85 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 57/176 (32%), Gaps = 22/176 (12%) Query: 118 EEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFS-TLVKGRL 176 A + P P + + E ++ K + SF L Sbjct: 201 NGLAQTASFHPLRPLFFVATQRSIRCYDLQKLELVKIVQPGAK---WISSFDVHPGGDNL 257 Query: 177 LSGSDDHTVALW-EVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 + GS D + LW ++ P K +R H++ I ++H LF S+D L+I Sbjct: 258 VVGSYDKRL-LWHDLDLSNRPYKTMR----FHTEAIRAVRFHKGGLPLFADASDDGSLQI 312 Query: 236 NDVRANNTT--------IDTVKCPQPFNTLAFS----HHSSNLLAAAGMDSYVYLY 279 + N + +K + N L H +AG D L+ Sbjct: 313 FHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 33/85 (38%), Gaps = 7/85 (8%) Query: 153 QSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIIN 212 Q+ + H+ +++ L +G DD TV +WE+ +G + V + + +N Sbjct: 14 QTIFRGHEGRVRSVAIDPT-GVALATGGDDGTVRVWELLTG----RQVWSVKLNGDEAVN 68 Query: 213 DNKWHNFNKDLF--GTVSEDSLLKI 235 +W ED L I Sbjct: 69 TVRWRPTKDTFILAAAAGEDIFLMI 93 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 9/79 (11%), Positives = 25/79 (31%), Gaps = 2/79 (2%) Query: 201 RTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTT-IDTVKCPQPFNTLAF 259 +T H + + T +D +++ ++ + + NT+ + Sbjct: 14 QTIFRGHEGRVRSVA-IDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRW 72 Query: 260 SHHSSNLLAAAGMDSYVYL 278 + AA ++L Sbjct: 73 RPTKDTFILAAAAGEDIFL 91 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 9/49 (18%), Positives = 22/49 (44%), Gaps = 1/49 (2%) Query: 333 TPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 +PD+ + + GH V ++P +A+ ++ ++VW+ Sbjct: 2 SPDELKPFPTVQQTIFRGHEGRVRSVAIDPTG-VALATGGDDGTVRVWE 49 Score = 37.9 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 33/88 (37%), Gaps = 15/88 (17%) Query: 290 HMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 GHE V ++ + + G D + +W+L + Q +G Sbjct: 16 IFRGHEGRVRSVAIDPTGVA-LATGGDDGTVRVWEL--LTGRQVWSVKLNG--------- 63 Query: 350 GHRSSVNDFDLNP-QIPWLVASAEEENI 376 +VN P + +++A+A E+I Sbjct: 64 --DEAVNTVRWRPTKDTFILAAAAGEDI 89 >5OQL-X nrPDB Length = 630 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 30/269 (11%), Positives = 78/269 (28%), Gaps = 48/269 (17%) Query: 153 QSTLKFHKDNGYALSFSTLVKGRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII 211 T + H + G+ + +G D + ++ KP++ + H D + Sbjct: 239 DKTYQGHLKAPLVVK--ASQDGKFVVTGGADKRLVVYNAAD----LKPIKAF-TQHRDAV 291 Query: 212 NDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG 271 + + + S+D +K+ + + ++ Sbjct: 292 TGLAF-RRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERC-VSVGA 349 Query: 272 MDSYVYLYDLR--------------NMKEPLHHM--------SGHEDAVNNLEFSTHVDG 309 D + + + H + + HE +++ + D Sbjct: 350 RDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAM--IDDD 407 Query: 310 VVVSSGSDNRLMMWDLKQIGAEQTPDDAE-------------DGVPELIMVHAGHRSSVN 356 + V+ + L +W +++ A D +P+ ++ A + Sbjct: 408 MFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGIT 467 Query: 357 DFDLNPQIPWLVASAEEENILQVWKCSHS 385 P L+ S + ++VW+ S Sbjct: 468 ALRTLP-YSDLIFSGSWDGCIRVWRLSED 495 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 27/182 (14%), Positives = 52/182 (28%), Gaps = 44/182 (24%) Query: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKF-----------H 159 + + H++EI + Q+ V+ T + E Q + H Sbjct: 323 VETLFGHQDEILDIDALGQERC-VSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKH 381 Query: 160 K-----------DNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRT------ 202 K G + + ++GSD+ +ALW + R Sbjct: 382 KLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPP 441 Query: 203 --WNDLHSDIINDNKWHN-------------FNKDLFGTVSEDSLLKINDVRANNTTIDT 247 D +D I D DL + S D +++ + + ++ Sbjct: 442 IKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEA 501 Query: 248 VK 249 V Sbjct: 502 VG 503 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 15/114 (13%), Positives = 31/114 (27%), Gaps = 29/114 (25%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSE----GLQSTLKFHKDNGYALSFST-- 170 HE + R + D ++ T + G + L+S + + + +S Sbjct: 394 HEGSMDRVAMI--DDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADE 451 Query: 171 ---------------------LVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTW 203 + SGS D + +W + + V Sbjct: 452 IPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAVGIL 505 >5K19-A nrPDB Length = 569 Score = 65.6 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 46/336 (13%), Positives = 107/336 (31%), Gaps = 47/336 (13%) Query: 57 QELIIGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYE 116 + + GT + + N+L A ++ Q + + + S + + Sbjct: 93 KRIYKGTQPTCHDFNHLT-ATAESVSLLVGFSAGQVQLIDPIKKE----TSKLFNEERLI 147 Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRL 176 + +T +++P ++ + G ++LY+ +T ++ SF+ Sbjct: 148 DKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAV------ 201 Query: 177 LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 HT P+ W + +N+ + + VS+D L++ Sbjct: 202 ------HTCK------SKSTRNPLLKW-TVGEGALNEFAFSP-DGKFLACVSQDGFLRVF 247 Query: 237 DVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHED 296 + + + +S ++ G D V ++ + + + GH+ Sbjct: 248 NFDSVELHGTMKSYFGGLLCVCWSPDGKYIV-TGGEDDLVTVWSFVDCRV-IARGHGHKS 305 Query: 297 AVNNLEFSTHVDGV-----VVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGH 351 V+ + F + V + SGSD DL G ++ Sbjct: 306 WVSVVAFDPYTTSVEEGDPMEFSGSDEDFQ--DLLHFGRDRANSTQSRLSKR-------- 355 Query: 352 RSSVNDFDLNP-QIPWLVASAEEENILQVWKCSHSL 386 N D P + + S ++ L +W + + Sbjct: 356 ----NSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDI 387 >5OV3-A nrPDB Length = 381 Score = 65.2 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 36/258 (13%), Positives = 91/258 (35%), Gaps = 20/258 (7%) Query: 133 IVATINGQGTVFLYSR-SEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVG 191 ++A G + ++ + G+ + H +L +S +L+S S D+ V+ W+V Sbjct: 39 LLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWS-RDGHKLVSASTDNIVSQWDVL 97 Query: 192 SGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCP 251 SG + I ++H +++ S + + + + V Sbjct: 98 SGDCDQRFRFP------SPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDD 151 Query: 252 QPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE----PLHHMSGHEDAVNNLEFSTHV 307 N +A + + + + + + + A+ ++EF+ Sbjct: 152 SDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFA-RK 210 Query: 308 DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSV--NDFDLNPQIP 365 + + +D + ++D ++I DG PE + + + Sbjct: 211 GSCFLINTADRIIRVYDGREILTC-----GRDGEPEPMQKLQDLVNRTPWKKCCFSGDGE 265 Query: 366 WLVASAEEENILQVWKCS 383 ++VA + ++ L +W+ S Sbjct: 266 YIVAGSARQHALYIWEKS 283 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 36/99 (36%), Gaps = 7/99 (7%) Query: 264 SNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 LLA D + ++D +S H V +L +S +VS+ +DN + W Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIA-KIISAHIHPVCSLCWS-RDGHKLVSASTDNIVSQW 94 Query: 324 DLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNP 362 D+ +Q ++ V H N + P Sbjct: 95 DVLSGDCDQ----RFRFPSPILKVQY-HPRDQNKVLVCP 128 Score = 33.6 bits (75), Expect = 0.14, Method: Composition-based stats. Identities = 12/74 (16%), Positives = 25/74 (33%), Gaps = 15/74 (20%) Query: 308 DGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWL 367 ++ +D R+++WD G + + + H V + Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAK--------------IISAHIHPVCSLCWSRDG-HK 81 Query: 368 VASAEEENILQVWK 381 + SA +NI+ W Sbjct: 82 LVSASTDNIVSQWD 95 >6E29-D nrPDB Length = 345 Score = 64.4 bits (155), Expect = 9e-11, Method: Composition-based stats. Identities = 52/309 (16%), Positives = 103/309 (33%), Gaps = 37/309 (11%) Query: 108 NIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS-RSEGLQSTLKFHKDNGYAL 166 NI T + H T R+ + + +A+ GTV ++ + G+ L+ H N +L Sbjct: 18 NITNTIRSGHS---TCVRFN-RKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSL 73 Query: 167 SFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGT 226 S+S LLS V LW++ G + + + H +N F Sbjct: 74 SWS-RCGRYLLSACQGWKVILWDLQDGKRYREVRF------RAPVYGAELHPWNHHQFAA 126 Query: 227 VSEDSLLKINDVRANNTTI--------DTVKCPQPFNTLAFS-----HHSSNLLAAAGMD 273 + + D+ T P + H ++ ++ A D Sbjct: 127 ALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGD 186 Query: 274 SY--------VYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 + + D R +E ++ + L + ++V + D + + + Sbjct: 187 HLLAGTTKGRLNIIDART-REIIYSEKIASGIITTLRLTESGRELLV-NAQDRIIRTFIV 244 Query: 326 KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 + A D E +R S N + ++ AS + L +W+ H Sbjct: 245 PNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHG 304 Query: 386 --LPIVGGP 392 + ++ GP Sbjct: 305 SLVRMLEGP 313 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 45/139 (32%), Gaps = 7/139 (5%) Query: 189 EVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTV 248 + P T HS + N D + D + I D+ Sbjct: 9 DYLLQDYPENITNTIRSGHSTCVR----FNRKGDFLASGRVDGTVVIWDLETMGVARKLR 64 Query: 249 KCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVD 308 + +L++S LL+A V L+DL++ K + V E Sbjct: 65 GHSKNITSLSWSRCGRYLLSAC-QGWKVILWDLQDGKR--YREVRFRAPVYGAELHPWNH 121 Query: 309 GVVVSSGSDNRLMMWDLKQ 327 ++ +++ M+ D+ + Sbjct: 122 HQFAAALFEDQPMLVDITE 140 Score = 51.3 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 45/132 (34%), Gaps = 12/132 (9%) Query: 140 QGTVFLYSRSEGLQSTLK-FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTK 198 L E + +T++ H + F+ L SG D TV +W++ + G K Sbjct: 7 SDDYLLQDYPENITNTIRSGHST---CVRFN-RKGDFLASGRVDGTVVIWDLETMGVARK 62 Query: 199 PVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLA 258 HS I W + L + + + + D++ V+ P Sbjct: 63 L-----RGHSKNITSLSWSRCGRYLL-SACQGWKVILWDLQDGK-RYREVRFRAPVYGAE 115 Query: 259 FSHHSSNLLAAA 270 + + AAA Sbjct: 116 LHPWNHHQFAAA 127 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 21/167 (12%), Positives = 50/167 (29%), Gaps = 10/167 (5%) Query: 122 TRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSD 181 T Y +++A + +R+ + + K L T LL + Sbjct: 177 TAIVYTASGDHLLAGTTKGRLNIIDARTREIIYSEKIASGIITTLRL-TESGRELLVNAQ 235 Query: 182 DHTVALWEVGSGG----DPTKPVRTWNDLHSDIINDNKWHNF-----NKDLFGTVSEDSL 232 D + + V + DP D++N W++ + + + + Sbjct: 236 DRIIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHE 295 Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY 279 L I + + + + + H + L A + ++ Sbjct: 296 LYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIW 342 >3DW8-B nrPDB Length = 447 Score = 61.0 bits (146), Expect = 8e-10, Method: Composition-based stats. Identities = 57/383 (14%), Positives = 115/383 (30%), Gaps = 103/383 (26%) Query: 90 PQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQ-DPNIVATINGQGTVFLYSR 148 S+ + E EE+I + R++PQ + T+ L+ Sbjct: 65 SHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKI 124 Query: 149 SE--------------------GLQSTLK---------------------FHKDNGYALS 167 SE +TL+ H + ++S Sbjct: 125 SERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSIS 184 Query: 168 FSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWND---LHSDIINDNKWHNFNKDLF 224 ++ + L +DD + LW + V +++I ++H + + F Sbjct: 185 INSDYETYL--SADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTF 242 Query: 225 GTVSEDSLLKINDVRA---NNTTIDTVKCPQP-------------FNTLAFSHHSSNLLA 268 S +++ D+RA + + P+ + + FSH ++ Sbjct: 243 VYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMM- 301 Query: 269 AAGMDS-YVYLYDLRNMKEPLHHMSGHEDAVNNL---------------EFSTHVDGVVV 312 D V ++DL P+ HE + L ++ D VV+ Sbjct: 302 --TRDYLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWN-GSDSVVM 358 Query: 313 SSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA-----GHRS----SVNDFDLNPQ 363 + +N M+D E+ P ++ G R SV+ D N + Sbjct: 359 TGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKK 418 Query: 364 IPWLVASAEEENILQVWKCSHSL 386 ++ +A W ++ Sbjct: 419 ---ILHTA--------WHPKENI 430 >5WLC-SG nrPDB Length = 573 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 41/282 (14%), Positives = 82/282 (29%), Gaps = 57/282 (20%) Query: 155 TLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDN 214 T + H D ++ S +++G D + +W S P K + T + + Sbjct: 231 TTEGHYDEILTVAASP-DGKYVVTGGRDRKLIVWSTESLS-PVKVIPTKDR--RGEVLSL 286 Query: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS 274 + + L+ + + D ++ + + ++ + D Sbjct: 287 AFRKNSDQLYASCA-DFKIRTYSINQFSQLEILYGHHDIVEDISALAMERC-VTVGARDR 344 Query: 275 YVYLYDL--------RNMKEPLHHMS---------GHEDAV--------------NNLEF 303 L+ + R EP + G + V +++ Sbjct: 345 TAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDV 404 Query: 304 STHVDGVVVSSGSDNR-LMMWDLKQIGAEQTPDDAEDGVPELIM-VHAGHRSS------- 354 + VD +GSDN + +W L + T A +PE +G Sbjct: 405 VSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQL 464 Query: 355 ----------VNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 + P + S L+VWK S +L Sbjct: 465 QGKKLLQPFWITSLYAIP-YSNVFISGSWSGSLKVWKISDNL 505 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 67/209 (32%), Gaps = 37/209 (17%) Query: 125 RYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHT 184 R+M ++ A G V SE + D S + ++GSD+ Sbjct: 371 RWMKEN----AKEGEDGEVKYPDESEAPLFFCEGSIDVV-----SMVDDFHFITGSDNGN 421 Query: 185 VALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTT 244 + LW + KP+ T H + D ++R Sbjct: 422 ICLWSLA----KKKPIFTERIAH-------GILPEPSFNDISGETDE-----ELRKRQLQ 465 Query: 245 IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY----DLRNMKEPLHHMSGHEDAVNN 300 + P +L + SN+ + + ++ +LR+ + L +SG + V Sbjct: 466 GKKLLQPFWITSLYAIPY-SNVFISGSWSGSLKVWKISDNLRSFEL-LGELSGAKGVVTK 523 Query: 301 LEFSTHVDG------VVVSSGSDNRLMMW 323 ++ ++ S ++RL W Sbjct: 524 IQVVESGKHGKEKFRILASIAKEHRLGRW 552 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 28/88 (31%), Gaps = 13/88 (14%) Query: 289 HHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVH 348 + GH D + + S VV+ G D +L++W E P ++ Sbjct: 230 NTTEGHYDEILTVAASP-DGKYVVTGGRDRKLIVW------------STESLSPVKVIPT 276 Query: 349 AGHRSSVNDFDLNPQIPWLVASAEEENI 376 R V L AS + I Sbjct: 277 KDRRGEVLSLAFRKNSDQLYASCADFKI 304 >4J0X-A nrPDB Length = 451 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 41/282 (14%), Positives = 82/282 (29%), Gaps = 57/282 (20%) Query: 155 TLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDN 214 T + H D ++ S +++G D + +W S P K + T + + Sbjct: 109 TTEGHYDEILTVAASP-DGKYVVTGGRDRKLIVWSTESLS-PVKVIPTKDR--RGEVLSL 164 Query: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS 274 + + L+ + + D ++ + + ++ + D Sbjct: 165 AFRKNSDQLYASCA-DFKIRTYSINQFSQLEILYGHHDIVEDISALAMERC-VTVGARDR 222 Query: 275 YVYLYDL--------RNMKEPLHHMS---------GHEDAV--------------NNLEF 303 L+ + R EP + G + V +++ Sbjct: 223 TAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDV 282 Query: 304 STHVDGVVVSSGSDNR-LMMWDLKQIGAEQTPDDAEDGVPELIM-VHAGHRSS------- 354 + VD +GSDN + +W L + T A +PE +G Sbjct: 283 VSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQL 342 Query: 355 ----------VNDFDLNPQIPWLVASAEEENILQVWKCSHSL 386 + P + S L+VWK S +L Sbjct: 343 QGKKLLQPFWITSLYAIP-YSNVFISGSWSGSLKVWKISDNL 383 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 67/209 (32%), Gaps = 37/209 (17%) Query: 125 RYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHT 184 R+M ++ A G V SE + D S + ++GSD+ Sbjct: 249 RWMKEN----AKEGEDGEVKYPDESEAPLFFCEGSIDVV-----SMVDDFHFITGSDNGN 299 Query: 185 VALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTT 244 + LW + KP+ T H + D ++R Sbjct: 300 ICLWSLA----KKKPIFTERIAH-------GILPEPSFNDISGETDE-----ELRKRQLQ 343 Query: 245 IDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY----DLRNMKEPLHHMSGHEDAVNN 300 + P +L + SN+ + + ++ +LR+ + L +SG + V Sbjct: 344 GKKLLQPFWITSLYAIPY-SNVFISGSWSGSLKVWKISDNLRSFEL-LGELSGAKGVVTK 401 Query: 301 LEFSTHVDG------VVVSSGSDNRLMMW 323 ++ ++ S ++RL W Sbjct: 402 IQVVESGKHGKEKFRILASIAKEHRLGRW 430 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 28/88 (31%), Gaps = 13/88 (14%) Query: 289 HHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVH 348 + GH D + + S VV+ G D +L++W E P ++ Sbjct: 108 NTTEGHYDEILTVAASP-DGKYVVTGGRDRKLIVW------------STESLSPVKVIPT 154 Query: 349 AGHRSSVNDFDLNPQIPWLVASAEEENI 376 R V L AS + I Sbjct: 155 KDRRGEVLSLAFRKNSDQLYASCADFKI 182 >5YZG-2 nrPDB Length = 646 Score = 58.7 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 73/213 (34%), Gaps = 19/213 (8%) Query: 176 LLSGSDDHTVALWE-VGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLK 234 +++ S D V W+ + G + K R+ H +I LF +V +D +K Sbjct: 104 IITASHDGHVKFWKKIEEGIEFVKHFRS----HLGVIESIAVS-SEGALFCSVGDDKAMK 158 Query: 235 INDVRANNTTID-----TVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH 289 + DV + + S++ A+ +++YD R +PLH Sbjct: 159 VFDVVNFDMINMLKLGYFPGQCEWIYC--PGDAISSVAASEKSTGKIFIYDGRGDNQPLH 216 Query: 290 HMSG-HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDA--EDGVPELIM 346 H + + + V VVSS + W + P + E + Sbjct: 217 IFDKLHTSPLTQIRLNP-VYKAVVSSDKSGMIEYW-TGPPHEYKFPKNVNWEYKTDTDLY 274 Query: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 A ++ +P +A+ + +++ Sbjct: 275 EFAKCKAYPTSVCFSPDGKK-IATIGSDRKVRI 306 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 47/307 (15%), Positives = 98/307 (31%), Gaps = 45/307 (14%) Query: 45 TPVQELDGGFIKQELIIGTHTS--GEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSL 102 P + ++EL + S +EEN ++ + L+ + E Y +L Sbjct: 18 DPEEPEKTELSERELAVAVAVSQENDEENEERWVGPLPVEATLAKKRKVLEFERVYLDNL 77 Query: 103 PAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSR-SEGL--QSTLKFH 159 P+ Y H + IT + + T + G V + + EG+ + H Sbjct: 78 PSASM---YERSYMHRDVITHVVCT--KTDFIITASHDGHVKFWKKIEEGIEFVKHFRSH 132 Query: 160 KDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNF 219 +++ S+ S DD + +++V + + +W Sbjct: 133 LGVIESIAVSS-EGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQ------CEWIYC 185 Query: 220 NKDLFGTV--SEDSLLKIN--DVRANNTTIDTVK--CPQPFNTLAFSHHSSNLLAAAGMD 273 D +V SE S KI D R +N + P + + A D Sbjct: 186 PGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYK---AVVSSD 242 Query: 274 SYVYL-----------------YDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGS 316 + ++ + L+ + + ++ FS + + GS Sbjct: 243 KSGMIEYWTGPPHEYKFPKNVNWEYKT-DTDLYEFAKCKAYPTSVCFSP-DGKKIATIGS 300 Query: 317 DNRLMMW 323 D ++ ++ Sbjct: 301 DRKVRIF 307 >6BX3-B nrPDB Length = 412 Score = 58.7 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 27/176 (15%), Positives = 59/176 (33%), Gaps = 13/176 (7%) Query: 116 EHEEEITRARYMPQDPNIVATINGQGTVFLYS----RSEGLQSTLKFHKDNGYALSFSTL 171 + + PNI+ +G + Y +LK N L S Sbjct: 165 PDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQN 224 Query: 172 VKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKW------HNFNKDLFG 225 + ++ S D T+ +E+ + + T + D+IN +W +N + L Sbjct: 225 GERLAINCS-DRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVA 283 Query: 226 T--VSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY 279 + S L I + + + + + +S ++++ VY++ Sbjct: 284 STHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 339 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 38/258 (14%), Positives = 85/258 (32%), Gaps = 37/258 (14%) Query: 123 RARYMPQDPNIVATINGQGTVFLYSRSE-----GLQSTLKFHKDNGYALSFSTLVKGRLL 177 ++ P + +A G + +Y + L H ++++S LL Sbjct: 30 CLQFSPC-GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-DGRLLL 87 Query: 178 SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTV---------- 227 + S D ++ LW++ P K +R + I +W + + L Sbjct: 88 TSSRDWSIKLWDLSKPSKPLKEIRFDS-----PIWGCQWLDAKRRLCVATIFEESDAYVI 142 Query: 228 --SEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNM- 284 S D + + T + H N++ ++ Y ++ Sbjct: 143 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH-PNIIIVGTSKGWLDFYKFHSLY 201 Query: 285 -KEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPE 343 E +H + + +L S + + + + SD + +++ D E+ E Sbjct: 202 QTECIHSLKITSSNIKHLIVSQNGE-RLAINCSDRTIRQYEIS--------IDDENSAVE 252 Query: 344 LIMVHAGHRSSVNDFDLN 361 L + H ++ +N N Sbjct: 253 LTLEHK-YQDVINKLQWN 269 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 12/85 (14%), Positives = 31/85 (36%), Gaps = 12/85 (14%) Query: 300 NLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFD 359 L+FS D + ++ L+++D+ P + + H + Sbjct: 30 CLQFSPCGD-YLALGCANGALVIYDMDTFRPICVPGN----------MLGAHVRPITSIA 78 Query: 360 LNPQIPWLVASAEEENILQVWKCSH 384 +P L+ ++ + +++W S Sbjct: 79 WSPDGR-LLLTSSRDWSIKLWDLSK 102 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 18/109 (16%), Positives = 35/109 (32%), Gaps = 12/109 (11%) Query: 194 GDPTKPVRTWNDLHSDIIN------DNKWHNFNKDLFGTVSEDSLLKINDVRANNTTI-- 245 DP ++ + + I ++ D + L I D+ Sbjct: 5 QDPFAVLKEHPEKLTHTIENPLRTECLQFSPC-GDYLALGCANGALVIYDMDTFRPICVP 63 Query: 246 --DTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 +P ++A+S LL + D + L+DL +PL + Sbjct: 64 GNMLGAHVRPITSIAWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLKEIR 111 >5TF2-A nrPDB Length = 407 Score = 57.9 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 3/83 (3%) Query: 241 NNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNN 300 N + T P + +H + LLA G D YV ++ + ++ E + HE + + Sbjct: 161 NLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSL-EKVLEFKAHEGEIED 219 Query: 301 LEFSTHVDGVVVSSGSDNRLMMW 323 L DG +V+ G D + +W Sbjct: 220 LALGP--DGKLVTVGRDLKASVW 240 Score = 41.7 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 12/81 (14%), Positives = 30/81 (37%), Gaps = 17/81 (20%) Query: 301 LEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDL 360 + F+ H + ++ + G+D + +W + + E ++ H + D L Sbjct: 178 VCFN-HDNTLLATGGTDGYVRVWKVPSL--------------EKVLEFKAHEGEIEDLAL 222 Query: 361 NPQIPWLVASAEEENILQVWK 381 P + + + VW+ Sbjct: 223 GPDGK--LVTVGRDLKASVWQ 241 Score = 37.1 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 47/136 (34%), Gaps = 26/136 (19%) Query: 73 LKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEE------------- 119 L+F +E+ + + + PA + + A+ +HE Sbjct: 111 LRFQAHQQQGNKAEKAGSKEQGPRQRKGAAPAEK---KCGAETQHEGLELRVENLQAVQT 167 Query: 120 -----EITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKF--HKDNGYALSFSTLV 172 + + D ++AT G V ++ L+ L+F H+ L+ Sbjct: 168 DFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVP-SLEKVLEFKAHEGEIEDLALGP-- 224 Query: 173 KGRLLSGSDDHTVALW 188 G+L++ D ++W Sbjct: 225 DGKLVTVGRDLKASVW 240 >5WLC-LW nrPDB Length = 554 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 40/249 (16%), Positives = 80/249 (32%), Gaps = 19/249 (7%) Query: 119 EEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLS 178 E + Q+ A F+Y LK H L F L++ Sbjct: 151 NETCHSATYLQNEQYFAVAQK-KYTFIYDHEGTELHRLKQH-IEARHLDFLP-YHYLLVT 207 Query: 179 GSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDV 238 + + +V +G ++ + + N W+ + + + + Sbjct: 208 AGETGWLKYHDVSTGQLVSEL--RTKAGPTMAMAQNPWN----AVMHLGHSNGTVSLWSP 261 Query: 239 RANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAV 298 + + P N++A S +A G D + ++D+RN K+ LH + Sbjct: 262 SMPEPLVKLLSARGPVNSIAID-RSGYYMATTGADRSMKIWDIRNFKQ-LHSVESLPTPG 319 Query: 299 NNLEFSTHVDGVVVSSGSDNRLMMWD--LKQIGAEQTPDDAEDGVPELIMVHAGH---RS 353 N+ S D +++ + +W LK G + + G P + H + Sbjct: 320 TNVSIS---DTGLLALSRGPHVTLWKDALKLSGDSKPCFGSMGGNPHRNTPYMSHLFAGN 376 Query: 354 SVNDFDLNP 362 V + P Sbjct: 377 KVENLGFVP 385 >5M89-A nrPDB Length = 329 Score = 54.8 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 35/245 (14%), Positives = 68/245 (27%), Gaps = 15/245 (6%) Query: 79 NLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATIN 138 L NE + + + T E +T + V Sbjct: 55 QASSLDLENECAAVGGLDGKLDIYSVVANKVERTLDIG--EPVTATEWTGTK---VVIGT 109 Query: 139 GQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTK 198 +G V +Y +T + H L+ L S D + +++ +G Sbjct: 110 AKGWVKVYDAGRE-SATFQTHAGPVTGLAVHP-GGRILASVGVDKSFVFYDLETGE---- 163 Query: 199 PVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLA 258 R + +H + +LF ++ + + P LA Sbjct: 164 --RVARGYADAALTTCAFHP-DGNLFAAGTQTGHILVFHTTTLEQAESFPLGT-PIQALA 219 Query: 259 FSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDN 318 FS + A S V ++DLR V ++ + + G+ Sbjct: 220 FSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGV 279 Query: 319 RLMMW 323 + M+ Sbjct: 280 TVQMY 284 >5WLC-LN nrPDB Length = 776 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 33/268 (12%), Positives = 86/268 (32%), Gaps = 28/268 (10%) Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLSG 179 + Y+P+ + +A+ + G++ + L + K H + L+ T + S Sbjct: 241 VWSVIYLPR-TDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDT-DNNYVFSA 298 Query: 180 SDDHTVALWEVG---SGGDPTKPVRTWNDLHSDIIND-NKWHNFNKDLFGTVSEDSLLKI 235 D + + S + + LH + I + + D + + L I Sbjct: 299 GVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVI 358 Query: 236 NDVRAN-NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE-------- 286 N + + N + +P++ + L+ + S V ++ + Sbjct: 359 NSLTSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSE-STVKIWTMGTDSSTEQNYKLV 417 Query: 287 PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIM 346 + + ++ S DG V+ G + ++ L+ +G + ++ + Sbjct: 418 CKLTLKD-DQNISTCSLSP--DGQVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDLLLRTS 474 Query: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEE 374 ++ S E++ Sbjct: 475 TKL--------VKFIDNSKIVICSCEDD 494 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 38/266 (14%), Positives = 78/266 (29%), Gaps = 37/266 (13%) Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS 180 + R R++ P + ++ HK N L T RL G Sbjct: 33 VHRCRFVDFTPATITSLAFS------------------HKSNINKL---TPSDLRLAIGR 71 Query: 181 DDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKD--LFGTVSEDSLLKINDV 238 + + +W + I W N N + ++ +++ D+ Sbjct: 72 SNGNIEIWNPRNNWFQEM---VIEGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDL 128 Query: 239 RANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHH---MSGHE 295 + +++ + S + L+ + V L D+ L H + E Sbjct: 129 ATGLPLRNYDCNSGVIWSISIN-DSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQE 187 Query: 296 DAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSV 355 V L + D V+ SD R+ +W ++ + + V Sbjct: 188 ARVLTLAW--KKDDFVIGGCSDGRIRIWSAQKNDENM----GRLLHTMKVDKAKKESTLV 241 Query: 356 NDFDLNPQIPWLVASAEEENILQVWK 381 P+ +AS + ++ W Sbjct: 242 WSVIYLPRTDQ-IASGDSTGSIKFWD 266 >6CHG-D nrPDB Length = 439 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 39/305 (12%), Positives = 87/305 (28%), Gaps = 42/305 (13%) Query: 110 RITAKYEHEEEI----TRARYMPQDPNIVATINGQGTVFLYSRSE----GLQSTLKF-HK 160 K H E+ ++ P+ + +A G + +Y + T H Sbjct: 15 EYPEKLTHTLEVPVAAVCVKFSPR-GDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHT 73 Query: 161 DNGYALSFSTLVKGRLLSGSDDHTVALWEVGS------GGDPTKPVRTWNDLHSDIINDN 214 + ++ +S L S D LW++ P+ + + + ++ Sbjct: 74 RSVQSVCWS-NDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVT 132 Query: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS 274 + + + + I +++ Sbjct: 133 VVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYT---LVACPHPTIESIIITGTSKG 189 Query: 275 YVYLY--DLRNMKE----PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 ++ + DL + E + + + S + +GSD + + L Sbjct: 190 WINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSG-TRIAINGSDRTIRQYQLIVE 248 Query: 329 GAEQTPDDAEDGVPELIMVHAGHRSS--VNDFDLNP------QIPWLVASA--EEENILQ 378 E +E G + + H+ +N N +LVASA + L Sbjct: 249 DNE-----SEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLY 303 Query: 379 VWKCS 383 +W+ S Sbjct: 304 LWETS 308 >4FHN-A nrPDB Length = 394 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 42/268 (15%), Positives = 88/268 (32%), Gaps = 40/268 (14%) Query: 169 STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNK------- 221 S + L D+TV L + T+ V H + +ND + Sbjct: 98 SPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAE 157 Query: 222 DLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYD- 280 + +V +D L I + + P ++ F + N L + + ++D Sbjct: 158 QVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFDW 217 Query: 281 --------------LRNMK-EPLHHM--------SGHEDAVNNLEFSTHVDGVVVSSGSD 317 ++N L+ + SG ++ N+ + +++ Sbjct: 218 TLNLSAEENSQTELVKNPWLLTLNTLPLVNTCHSSGIASSLANVRWIGSDGSGILAMCKS 277 Query: 318 NRLMMWDL--KQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWL--VASA-E 372 + W+L E + + G L+ G + P ++ A+A Sbjct: 278 GAWLRWNLFANNDYNEISDSTMKLGPKNLLPNVQGISLFPSLLGACPHPRYMDYFATAHS 337 Query: 373 EENILQVWKC----SHSLPIVGGPPKVN 396 + ++Q+ S+S+PI G P V+ Sbjct: 338 QHGLIQLINTYEKDSNSIPIQLGMPIVD 365 Score = 35.5 bits (80), Expect = 0.046, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 38/101 (37%), Gaps = 16/101 (15%) Query: 300 NLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFD 359 N+ S + DN + + I +T + +GH + VND D Sbjct: 94 NVNSSPVYSLFLACVCQDNTVRL----IITKNETIITQHVLGGK-----SGHHNFVNDID 144 Query: 360 L-------NPQIPWLVASAEEENILQVWKCSHSLPIVGGPP 393 + N ++AS ++ L +W+ + PI+ G P Sbjct: 145 IADVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYP 185 >5MC6-j nrPDB Length = 397 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 55/311 (17%), Positives = 107/311 (34%), Gaps = 70/311 (22%) Query: 66 SGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRAR 125 S + YLK + ++L NE+P++++ + + ++ + E + Sbjct: 31 SCSGDGYLKVWD----NKLLDNENPKDKSYSHF--VHKSGLHHVDVLQAIERDAF----- 79 Query: 126 YMPQDPNIVATINGQGTVFLYSRSEG-------------LQSTLKFHKDNGYALSFSTLV 172 + +VAT + G + Y + L S +K H +AL + Sbjct: 80 ----ELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHS--FWALKWGASN 133 Query: 173 KGRLLS----GSD-DHTVALW-------EVGSGGDPTKPVRTWNDLHSDIINDNKWHNF- 219 RLLS +D T +W E S P + +++ Sbjct: 134 D-RLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSV 192 Query: 220 ---NKDLFGTVSEDSLLKINDVRANNTTIDTVKC------PQPFNTLAFSHHSSNLLAAA 270 + L T + ++I+++ + ++ FS S LLA A Sbjct: 193 DISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGS-LLAIA 251 Query: 271 GMDSY---VYLYD------LRNMKEPLHHMSG------HEDAVNNLEFSTHVDGVVVSSG 315 + + LY+ + ++ P H H V +L F+ + + S+G Sbjct: 252 HDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLC-SAG 310 Query: 316 SDNRLMMWDLK 326 D +L WD+K Sbjct: 311 WDGKLRFWDVK 321 Score = 48.6 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 30/182 (16%), Positives = 69/182 (37%), Gaps = 29/182 (15%) Query: 139 GQGTVFLYSRSEGLQSTLKF-HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPT 197 +S + LQ T++ + +A S +G + +G ++ TV + E+ + Sbjct: 162 SNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERGLIATGFNNGTVQISELST----L 217 Query: 198 KPVRTWNDLHSDI-----INDNKWHNFNKDLFGTVSEDSL---LKINDVR---------- 239 +P+ + HS I I K+ L + + + + + Sbjct: 218 RPLYNFESQHSMINNSNSIRSVKFSPQGS-LLAIAHDSNSFGCITLYETEFGERIGSLSV 276 Query: 240 ---ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHED 296 ++ ++ +L+F+ S L +AG D + +D++ KE + ++ H D Sbjct: 277 PTHSSQASLGEFAHSSWVMSLSFN-DSGETLCSAGWDGKLRFWDVKT-KERITTLNMHCD 334 Query: 297 AV 298 + Sbjct: 335 DI 336 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 24/127 (18%), Positives = 42/127 (33%), Gaps = 22/127 (17%) Query: 92 EEAGEEYQSSLPAPRSNIRITAK---YEHEEEITRARYMPQDPNIVATINGQ---GTVFL 145 G S L R ++ + I ++ PQ +++A + G + L Sbjct: 204 FNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQ-GSLLAIAHDSNSFGCITL 262 Query: 146 YSRSEG------------LQSTLK--FHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVG 191 Y G Q++L H +LSF+ + L S D + W+V Sbjct: 263 YETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGE-TLCSAGWDGKLRFWDVK 321 Query: 192 SGGDPTK 198 + T Sbjct: 322 TKERITT 328 Score = 35.5 bits (80), Expect = 0.045, Method: Composition-based stats. Identities = 40/258 (15%), Positives = 89/258 (34%), Gaps = 45/258 (17%) Query: 157 KFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWN-------DLHSD 209 K H + +++ + +S S D + +W+ + ++++ H D Sbjct: 13 KAHDADIFSV---SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVD 69 Query: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTT----------IDTVKCPQPFNTLAF 259 ++ + F L T S L + + T +D+ F L + Sbjct: 70 VLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKW 129 Query: 260 SHHS----SNLLAAAGMDSYVYLY------DLRNM----KEPLHHMSGH-EDAVNNLEFS 304 + S+ L A + Y++ D N P + G E + +F+ Sbjct: 130 GASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFA 189 Query: 305 THVD---GVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLN 361 T VD ++++G +N + QI T + + M++ + +S+ + Sbjct: 190 TSVDISERGLIATGFNNGTV-----QISELSTLRPLYNFESQHSMIN--NSNSIRSVKFS 242 Query: 362 PQIPWLVASAEEENILQV 379 PQ L + + + + Sbjct: 243 PQGSLLAIAHDSNSFGCI 260 >2P9P-C nrPDB Length = 372 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 85/263 (32%), Gaps = 43/263 (16%) Query: 118 EEEITRARYMPQDPNI-VATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRL 176 ++ T+ P + + + +G V + LK H + ++ R+ Sbjct: 17 NKDRTQIAICPNNHEVHIYEKSGNKWVQV--------HELKEHNGQVTGVDWAP-DSNRI 67 Query: 177 LSGSDDHTVALWEVGSGG-DPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 ++ D +W + PT + N +W N+ F S ++ I Sbjct: 68 VTCGTDRNAYVWTLKGRTWKPTLVILRIN----RAARCVRWAP-NEKKFAVGSGSRVISI 122 Query: 236 --NDVRANNTTIDTVKCPQPFNTLAFS-HHSSNLLAAAGMDSYVYLY-------DLRNMK 285 + + +K P L+ H +S LLAA D ++ + R Sbjct: 123 CYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAP 182 Query: 286 EP----------LHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD------LKQIG 329 P + S V+ + FS V D+ + + D + + Sbjct: 183 TPWGSKMPFGELMFESSSSCGWVHGVCFS-ANGSRVAWVSHDSTVCLADADKKMAVATLA 241 Query: 330 AEQTPDDAEDGVPELIMVHAGHR 352 +E P A + E +V AGH Sbjct: 242 SETLPLLAVTFITESSLVAAGHD 264 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 27/183 (14%), Positives = 64/183 (34%), Gaps = 17/183 (9%) Query: 202 TWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTI--DTVKCPQPFNTLAF 259 ++ + I+ + W N ++ + + I + N + + + + Sbjct: 2 AYHSFLVEPISCHAW-NKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDW 60 Query: 260 SHHSSNLLAAAGMDSYVYLYDLRN-MKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDN 318 + SN + G D Y++ L+ +P + A + ++ + V SGS Sbjct: 61 AP-DSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGS-- 117 Query: 319 RLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQ 378 + I + + V + I RS+V D +P L+A+ + + Sbjct: 118 -------RVISICYFEQENDWWVCKHIKKPI--RSTVLSLDWHPN-SVLLAAGSCDFKCR 167 Query: 379 VWK 381 ++ Sbjct: 168 IFS 170 >6N8P-A nrPDB Length = 979 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 38/247 (15%), Positives = 71/247 (28%), Gaps = 42/247 (17%) Query: 126 YMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTV 185 Y P I+A G + LY L + + + +L++ DD+++ Sbjct: 29 YSPS-LRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLP-GQCQLVTLLDDNSL 86 Query: 186 ALWEVGSGG------------------------------DPTKPVRTWNDLHSDIINDNK 215 LW + G + + S + + Sbjct: 87 HLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQ 146 Query: 216 WHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSY 275 F T+S D++L+ R L N + Sbjct: 147 LPAFRALEDRTISSDAVLQ----RLPEEARHRRVFEM-VEALQEHPRDPNQILIGYSRGL 201 Query: 276 VYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPD 335 V ++DL+ + H +S + N+ + ++VS SD W + Q P+ Sbjct: 202 VVIWDLQGSRVLYHFLS--SQQLENIWW-QRDGRLLVSCHSDGSYCQWPVS--SEAQQPE 256 Query: 336 DAEDGVP 342 VP Sbjct: 257 PLRSLVP 263 Score = 37.5 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 48/286 (16%), Positives = 87/286 (30%), Gaps = 46/286 (16%) Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGS 180 + + P+DPN + +G V ++ G + F + L+S Sbjct: 180 VEALQEHPRDPNQILIGYSRGLVVIWDLQ-GSRVLYHFLSSQQLENIWWQRDGRLLVSCH 238 Query: 181 DDHTVALWEVGSGGDPTKPVRT---WNDLHSDIINDNKWHNFNKDL----------FGTV 227 D + W V S +P+R+ + I W + L + Sbjct: 239 SDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASY 298 Query: 228 SEDSLLK-INDVRANNTTIDTVKCPQPFNTL-----AFSHHSSNLLAAAGMDSYVYLYDL 281 + + I+D + T D F L A + L + V + DL Sbjct: 299 GDRHCISVIHDGQ--QTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVI-DL 355 Query: 282 RNMKEPLHHM----SGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDA 337 + P + S H A+ S HV + L +W+ +I A + +A Sbjct: 356 QTAGWPPVQLPYLASLHCSAITC---SHHVSNI--------PLKLWE--RIIAAGSRQNA 402 Query: 338 EDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 E + P L+ + E+ ++ W S Sbjct: 403 HFSTMEWPIDGG------TSLTPAPPQRDLLLTGHEDGTVRFWDAS 442 Score = 35.9 bits (81), Expect = 0.030, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 31/76 (40%), Gaps = 4/76 (5%) Query: 117 HEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRL 176 H IT + + + + SR ST+++ D G +L+ + + L Sbjct: 372 HCSAITC----SHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLL 427 Query: 177 LSGSDDHTVALWEVGS 192 L+G +D TV W+ Sbjct: 428 LTGHEDGTVRFWDASG 443 Score = 34.8 bits (78), Expect = 0.066, Method: Composition-based stats. Identities = 39/266 (14%), Positives = 81/266 (30%), Gaps = 44/266 (16%) Query: 98 YQSSLPAPRSNIRITAKYEHEEEITRARYMPQ--------DPNIVATINGQGTVFLYSRS 149 +Q +P R H+ + T + + + + AT + + + + Sbjct: 289 FQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEE 348 Query: 150 EGLQSTLKFHKDNGYALSFSTLVKGRLLS-------GSDDHT---VALWE--VGSGGDPT 197 E + L+ + + L S S + + LWE + +G Sbjct: 349 ELVVIDLQ-------TAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQN 401 Query: 198 KPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTL 257 T D +DL T ED ++ D A+ + + Sbjct: 402 AHFSTMEWP-IDGGTSLTPAPPQRDLLLTGHEDGTVRFWD--ASGVCLRLLYKLSTVRVF 458 Query: 258 AFSHHSSNLLAAAGMD-----SYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVV 312 + +A G D V +D + L + ++S G + Sbjct: 459 LTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGI-----QKIFLCKYS----GYLA 509 Query: 313 SSGSDNRLMMWDLKQIGAEQTPDDAE 338 +G+ ++++ +L AEQ + E Sbjct: 510 VAGTAGQVLVLELNDEAAEQAVEQVE 535 >6CVZ-A nrPDB Length = 351 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 17/98 (17%), Positives = 40/98 (40%), Gaps = 1/98 (1%) Query: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL 266 H I + ++ + L + S D+ +K+ + N T + T +P + + +N Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETN-TVVQTYNAGRPVWSCCWCLDEANY 131 Query: 267 LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFS 304 + A + + +YD+RN + + + + S Sbjct: 132 IYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLS 169 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 61/147 (41%), Gaps = 21/147 (14%) Query: 123 RARYMPQDP-NIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSD 181 +A ++P +++T N + + ++ H L+FS+ ++G LLS S Sbjct: 47 QASFLPGFGVKMLSTANMKSSQYI-----------PMHGKQIRGLAFSSYLRGLLLSASL 95 Query: 182 DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRAN 241 D+T+ L + + V+T+N + W + + + + DVR Sbjct: 96 DNTIKLTSLETN----TVVQTYNAG--RPVWSCCWCLDEANYIYAGLANGSILVYDVRNT 149 Query: 242 NTTIDTV---KCPQPFNTLAFSHHSSN 265 ++ + + K P +L++ +++ Sbjct: 150 SSHVQELVAQKARCPLVSLSYMPRAAS 176 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 26/163 (15%), Positives = 60/163 (36%), Gaps = 9/163 (5%) Query: 233 LKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS 292 +K+ ++ + LAFS + LL +A +D+ + L L + + Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 115 Query: 293 GHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHR 352 G V + + + + ++ ++++D++ + A+ L+ + R Sbjct: 116 G--RPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPR 173 Query: 353 SSVNDFDLNPQIPWLVASAEE----ENILQVWKCSHSLPIVGG 391 ++ F P L + E+ E + H LP+ G Sbjct: 174 AASAAF---PYGGVLAGTLEDASFWEQKMDFSHWPHVLPLEPG 213 >6IYY-A nrPDB Length = 317 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 31/206 (15%), Positives = 64/206 (31%), Gaps = 26/206 (12%) Query: 177 LSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIN 236 L G V +W+ K S + K +D V DS++K+ Sbjct: 65 LVGGGKKKVMIWD------DLKKKTVIEIEFSTEVKAVK---LRRDRIVVV-LDSMIKVF 114 Query: 237 DVRANNTTID-TVKCPQPFNTLAFSHHSSNLLAA--AGMDSYVYLYDLRNMKEPLHHMSG 293 N + C P +S+N L A +V L DL + ++P + Sbjct: 115 TFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPA 174 Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 HE ++ + + + +S + ++D Q + Sbjct: 175 HEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELR------------RGSQAA 222 Query: 354 SVNDFDLNPQIPWLVASAEEENILQV 379 ++ + N L+ + + + + Sbjct: 223 NIYCINFNQDAS-LICVSSDHGTVHI 247 Score = 30.9 bits (68), Expect = 0.92, Method: Composition-based stats. Identities = 19/153 (12%), Positives = 42/153 (27%), Gaps = 27/153 (17%) Query: 227 VSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE 286 ++ ++ + + + L G V ++D Sbjct: 24 CGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKKVMIWDDLK--- 80 Query: 287 PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIM 346 + V +EFST V V + D +++ D + Sbjct: 81 --------KKTVIEIEFSTEVKAVKLR--RDRIVVVLD--------------SMIKVFTF 116 Query: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 H H+ V + NP+ ++ ++L Sbjct: 117 THNPHQLHVFETCYNPKGLCVLCPNSNNSLLAF 149 >3JB9-S nrPDB Length = 488 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 29/74 (39%), Gaps = 1/74 (1%) Query: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 I H + +LF E+ L+ + + N P TL F + L+ Sbjct: 336 ITSLAVHP-DGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTT 394 Query: 271 GMDSYVYLYDLRNM 284 DS ++++DLR Sbjct: 395 NDDSDIFIWDLRKS 408 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 56/347 (16%), Positives = 114/347 (32%), Gaps = 59/347 (17%) Query: 61 IGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEE 120 IGT +S ++ E+ + + + E+ L + R ++ K+ ++ Sbjct: 136 IGTVSS----KTIEVQEVEMGESDDQLKTSLRSTVEKTFQELSSKRKRTKLQPKWATDDA 191 Query: 121 ITRA-RYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSG 179 +++ + P I+ + + T + E L HKD L + ++ G Sbjct: 192 VSQLLQATPS--TILENLETESTTSFFPSPENSSFVLCLHKDELLCLDIQSNSTLKIFEG 249 Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVR 239 S W S +D I+ ++ + +V E + D Sbjct: 250 SA--LACCWLTSSK---------IAVATADAISIFEF-PVSSSGLQSVGEPTSSIPID-- 295 Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVN 299 + N L LLAA+ + Y++ L+ + ++ H + Sbjct: 296 ------------EKVNFLQAHPSGEYLLAAS--NEKCYIFSLK-SQVYNITVAQH---IT 337 Query: 300 NLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFD 359 +L DG + +G +N +L+ E + H S V Sbjct: 338 SLAVHP--DGNLFVAGLENG----ELRFF---------ETSSGNELTKFGPHSSPVKTLQ 382 Query: 360 LNPQIPWLVASAEEENILQVWKCSHS-----LPIVGGPPKVNKDIIS 401 WLV + +++ + +W S +P+ V+ DI S Sbjct: 383 FGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAVSLDITS 429 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 23/159 (14%), Positives = 49/159 (30%), Gaps = 8/159 (5%) Query: 121 ITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKF-HKDNGYALSFSTLVKGRLLSG 179 IT P D N+ G + + S G + T H L F +++ Sbjct: 336 ITSLAVHP-DGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTT 394 Query: 180 SDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVR 239 +DD + +W++ K + ++ L + E + I Sbjct: 395 NDDSDIFIWDLRKSELVQKIPLQTK------VAAVSLDITSQLLVSSDGETLYVHIYVKS 448 Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYL 278 + + + + L + + LL + + + L Sbjct: 449 SKSWRCMSQTHVSSISNLVWLNELHQLLFSTSNGAILRL 487 >5WLC-LV nrPDB Length = 707 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 46/327 (14%), Positives = 107/327 (32%), Gaps = 39/327 (11%) Query: 77 EINLPKEILSNEDPQE---EAGEEYQSSLPAPRSNI------RITAKYEHEEEITRARYM 127 + L ++ +E + +Y + + I ++ K++ + + Sbjct: 46 RVELIQDFEFSEASNKIKVSRDGQYCMATGTYKPQIHVYDFANLSLKFDRHTDAENVDFT 105 Query: 128 PQDPNIVATINGQGTVFL-YSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVA 186 + +++ Q + + GL T + K G +L ++ + + S + Sbjct: 106 ILSDDWTKSVHLQNDRSIQFQNKGGLHYTTRIPK-FGRSLVYNKVNCDLYVGASGNELYR 164 Query: 187 LWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTID 246 L + G ++ IN+ L +E ++++ D R+ + Sbjct: 165 L-NLEKGRFLNPFKLDTEGVNHVSINEV------NGLLAAGTETNVVEFWDPRSRSRVSK 217 Query: 247 TVKCPQ----PFNTLAFSHHSSNL-LAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNL 301 PF S + L A + Y Y+YDLR + + G+ + + Sbjct: 218 LYLENNIDNRPFQVTTTSFRNDGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKI 277 Query: 302 EF--STHVDGVVVSSGSDNRL-MMWDLKQIGAEQTPDDAED--------GVPELIMVHAG 350 + + + +V+ D R+ +WD A + + + D G + Sbjct: 278 IWLDNVGTENKIVTC--DKRIAKIWDRLDGKAYASMEPSVDINDIEHVPGTGMFFTANES 335 Query: 351 ---HRSSVNDFDLNPQIPWLVASAEEE 374 H + +P+ + S EE Sbjct: 336 IPMHTYYIPSLGPSPRWCSFLDSITEE 362 >5AMS-A nrPDB Length = 431 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 40/263 (15%), Positives = 86/263 (32%), Gaps = 30/263 (11%) Query: 110 RITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEG------LQSTLKFHKDNG 163 ++ ++ + EEI + P A G+V+ Y +E L S +D Sbjct: 146 KLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCS 205 Query: 164 YALSFSTLVKGR---LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNF- 219 +T L++ S D T+ W +G K + Sbjct: 206 MGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPET 265 Query: 220 ----NKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQ----------PFNTLAFSHHSSN 265 N + S + LL + + + + ++++S + Sbjct: 266 LTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWS-SKFS 324 Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL 325 L+A + + LYD + + ED+V L F + + +S + ++ ++ Sbjct: 325 LMAIGLVCGEILLYDTSAWRVRHKFVL--EDSVTKLMF---DNDDLFASCINGKVYQFNA 379 Query: 326 KQIGAEQTPDDAEDGVPELIMVH 348 + + GV + I++H Sbjct: 380 RTGQEKFVCVGHNMGVLDFILLH 402 Score = 36.3 bits (82), Expect = 0.023, Method: Composition-based stats. Identities = 18/148 (12%), Positives = 52/148 (35%), Gaps = 18/148 (12%) Query: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH---HMSGHED 296 +NN+ K + H + L+ G D+ +L+ + +P ++G+ + Sbjct: 54 SNNSLTYFDKHTDSVFAIG-HHPNLPLVCTGGGDNLAHLW--TSHSQPPKFAGTLTGYGE 110 Query: 297 AVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVN 356 +V + F++ G +V++ ++++ + G + + Sbjct: 111 SVISCSFTSEG-GFLVTADMSGKVLV-----------HMGQKGGAQWKLASQMQEVEEIV 158 Query: 357 DFDLNPQIPWLVASAEEENILQVWKCSH 384 +P I A + + ++ + Sbjct: 159 WLKTHPTIARTFAFGATDGSVWCYQINE 186 Score = 32.5 bits (72), Expect = 0.38, Method: Composition-based stats. Identities = 11/53 (20%), Positives = 18/53 (33%), Gaps = 1/53 (1%) Query: 339 DGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGG 391 D + H SV +P +P V + +N+ +W P G Sbjct: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPL-VCTGGGDNLAHLWTSHSQPPKFAG 103 >2VDU-B nrPDB Length = 450 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 24/178 (13%), Positives = 57/178 (32%), Gaps = 18/178 (10%) Query: 119 EEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLS 178 I R + ++A + ++ ++ + ++ LK K + + + Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCF-----SKRPNAISI 157 Query: 179 GSDDHTVAL---------WEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 DD TV + ++ S + S + + + + + F S+ Sbjct: 158 AEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSD 217 Query: 230 -DSLLKINDVRANNTTID-TVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMK 285 D +KI+ + + LL +AG D ++ +D + K Sbjct: 218 RDEHIKISHYPQCFIVDKWLFGHKHFVS--SICCGKDYLLLSAGGDDKIFAWDWKTGK 273 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 25/182 (13%), Positives = 58/182 (31%), Gaps = 29/182 (15%) Query: 170 TLVKGRLLSGSD-DHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVS 228 T + RL++ +D D ++ +++V +R + Sbjct: 111 TSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKR-----------PNAISIAE 159 Query: 229 EDSLLKIND-------------VRANNTTIDTVKCPQPFNTLAFSHHSS--NLLAAAGMD 273 +D+ + I D T + + S + + D Sbjct: 160 DDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRD 219 Query: 274 SYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQT 333 ++ + + GH+ V+++ D +++S+G D+++ WD K T Sbjct: 220 EHIKISHYPQCFIVDKWLFGHKHFVSSI--CCGKDYLLLSAGGDDKIFAWDWKTGKNLST 277 Query: 334 PD 335 D Sbjct: 278 FD 279 >2I3T-A nrPDB Length = 341 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 35/236 (14%), Positives = 75/236 (31%), Gaps = 27/236 (11%) Query: 107 SNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYS---RSEGLQST--LKFHKD 161 + A +E + R + + + G + + +G+ + L + Sbjct: 88 GSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNT 147 Query: 162 NGYALSFS-TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFN 220 F+ RL+ G ++ V + + D + I D Sbjct: 148 KVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIE--ESGLKYQIRDVALLPKE 205 Query: 221 KDLFGTVSED---------------SLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN 265 ++ + S D + K R + + P N++ FS Sbjct: 206 QEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKF 265 Query: 266 LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLM 321 L AG D + ++L+ K+ + +ED+V + S D ++ + SD+ Sbjct: 266 LY-TAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACS---DNILCLATSDDTFK 317 Score = 35.2 bits (79), Expect = 0.048, Method: Composition-based stats. Identities = 31/223 (13%), Positives = 77/223 (34%), Gaps = 16/223 (7%) Query: 160 KDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNF 219 KD + L++ S D ++ +++ +++ H ++ N N Sbjct: 11 KDYISDIKIIPSKSLLLIT-SWDGSLTVYKFDIQAKNVDLLQSLRYKHP-LLCCNFIDNT 68 Query: 220 NKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLY 279 + ++ + +LK++ + + + T + + L AA D + + Sbjct: 69 DLQIYVGTVQGEILKVDLIGSPSFQALTNNEAN-LGICRICKYGDDKLIAASWDGLIEVI 127 Query: 280 DLRNMK---EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDD 336 D RN + +++ + V N F+ + + G +N + W + + Sbjct: 128 DPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTI 187 Query: 337 AEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQV 379 E G+ + + D L P+ A + + + V Sbjct: 188 EESGL----------KYQIRDVALLPKEQEGYACSSIDGRVAV 220 >5WLC-LH nrPDB Length = 896 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 18/66 (27%), Positives = 32/66 (48%), Gaps = 1/66 (1%) Query: 134 VATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSG 193 +A G + + S ++ LK+H D+ +LSFS LLSG + ++LW++ + Sbjct: 271 LAVGFASGVISIVSLADLQIRLLKWHIDSVLSLSFS-HDGSYLLSGGWEKVMSLWQLETN 329 Query: 194 GDPTKP 199 P Sbjct: 330 SQQFLP 335 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 40/86 (46%), Gaps = 8/86 (9%) Query: 251 PQPFNTLAFSHHSSNLLA--AAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVD 308 + +++A + L A+G+ S V L DL+ + + H D+V +L FS H Sbjct: 256 TRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-----IRLLKWHIDSVLSLSFS-HDG 309 Query: 309 GVVVSSGSDNRLMMWDLKQIGAEQTP 334 ++S G + + +W L+ + P Sbjct: 310 SYLLSGGWEKVMSLWQLETNSQQFLP 335 Score = 31.3 bits (69), Expect = 0.74, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 17/37 (45%), Gaps = 1/37 (2%) Query: 250 CPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE 286 +L+FSH S LL + G + + L+ L + Sbjct: 296 HIDSVLSLSFSHDGSYLL-SGGWEKVMSLWQLETNSQ 331 >3DWL-C nrPDB Length = 377 Score = 36.3 bits (82), Expect = 0.024, Method: Composition-based stats. Identities = 17/115 (14%), Positives = 39/115 (33%), Gaps = 14/115 (12%) Query: 251 PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL-RNMKEPLHHMSGHEDAVNNLEFSTHVDG 309 P+P AF+ + + V LY+ N + S H+ V ++++ + Sbjct: 11 PKPSYEHAFNSQRTE-FVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSN- 68 Query: 310 VVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI 364 +V+ D +++ + DG + +V + +P Sbjct: 69 RIVTCSQDRNAYVYEKRP-----------DGTWKQTLVLLRLNRAATFVRWSPNE 112 Score = 32.8 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 27/175 (15%), Positives = 57/175 (32%), Gaps = 17/175 (9%) Query: 163 GYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKD 222 +A+ FS L D +V + S + L + W N + Sbjct: 208 VHAVGFSPS-GNALAYAGHDSSVTI-AYPSAPEQPPRALITVKLSQLPLRSLLWANESAI 265 Query: 223 LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSN--------LLAAAGMDS 274 + + +L + T D + +F+H + ++ + S Sbjct: 266 VAAGYNYSPILLQGNESGWAHTRDLDAGT---SKTSFTHTGNTGEGREEEGPVSFTALRS 322 Query: 275 YVYLYDLRNMKEPLHHM-SGHEDAVNNLEFS---THVDGVVVSSGSDNRLMMWDL 325 DL+ + + + + H++ + L SSG+D R+++W L Sbjct: 323 TFRNMDLKGSSQSISSLPTVHQNMIATLRPYAGTPGNITAFTSSGTDGRVVLWTL 377 >5WLC-LL nrPDB Length = 643 Score = 34.0 bits (76), Expect = 0.10, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 72/206 (34%), Gaps = 12/206 (5%) Query: 121 ITRARYMP---QDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLL 177 +T +++ D + G ++LYS + T KF N Y + L+ +L Sbjct: 60 VTCLKWVNLASSDTVAIILGMNNGEIWLYSVLAN-EVTYKFTTGNSYEIKDIDLMGNQLW 118 Query: 178 SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKIND 237 +++ K ++ + + +N + + + + D Sbjct: 119 CIDSSDAFYQFDL----LQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVASHSISLID 174 Query: 238 VRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDA 297 + + P +TL + ++ A D ++ +YD+ + ++ E Sbjct: 175 IEEKKVVMTFPGHVSPVSTLQVI-TNEFFISGAEGDRFLNVYDIHSGMTKCVLVA--ESD 231 Query: 298 VNNLEFSTHVDGVVVSSGSDNRLMMW 323 + L S D + V++ D L ++ Sbjct: 232 IKELSHSGQADSIAVTT-EDGSLEIF 256 >5WLC-LS nrPDB Length = 594 Score = 34.0 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 47/125 (37%), Gaps = 9/125 (7%) Query: 165 ALSFSTLVKGR-LLSGSDDHTVALWEVGSGGDPTKPVRTWN-DLHSDIINDNKWHNFNKD 222 AL S + + R L GS+ V L++ + + P D + I++ ++ + Sbjct: 470 ALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSP-DGQ 528 Query: 223 LFGTVSE--DSLLKINDVRANNTTIDTVKCPQP---FNTLAFSHHSSNLLAAAGMDSYVY 277 + S L++ + + + + P ++AFS LLA V Sbjct: 529 ILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGG-LLAVGNEQGKVR 587 Query: 278 LYDLR 282 L+ L Sbjct: 588 LWKLN 592 Score = 33.2 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 23/128 (17%), Positives = 40/128 (31%), Gaps = 15/128 (11%) Query: 238 VRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL---RNMKEPLHHMSGH 294 VR + +L+F LL G D + +Y + N H+ G Sbjct: 236 VRLKDANASHPSHSA-IQSLSFHPSKP-LLLTGGYDKTLRIYHIDGKTNHLVTSLHLVG- 292 Query: 295 EDAVNNLEF----STHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAG 350 + F S + ++G + WDL + + ++ E G Sbjct: 293 -SPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDL----SLENLTHSQTAKIEKFSRLYG 347 Query: 351 HRSSVNDF 358 H S+ F Sbjct: 348 HESTQRSF 355 Score = 29.8 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 41/116 (35%), Gaps = 12/116 (10%) Query: 148 RSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLH 207 R + ++ H +LSF LL+G D T+ ++ + + V + + + Sbjct: 237 RLKDANASHPSHS-AIQSLSFHPSKP-LLLTGGYDKTLRIYHIDGKTNH--LVTSLHLVG 292 Query: 208 SDIINDNKW---HNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFS 260 S I + N N+ T + D+ +++ + Q FS Sbjct: 293 SPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDL-----SLENLTHSQTAKIEKFS 343 >3OND-A nrPDB Length = 488 Score = 31.3 bits (69), Expect = 0.79, Method: Composition-based stats. Identities = 20/115 (17%), Positives = 28/115 (24%), Gaps = 10/115 (8%) Query: 109 IRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSF 168 I + H + R PQ V G + L H + SF Sbjct: 358 IDMLGLETHPG-VKRITIKPQTDRWVFPETNTGIIILAEGRLMNLGCATGHPSFVMSCSF 416 Query: 169 STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDL 223 + V +L LW S G K V + + L Sbjct: 417 TNQVIAQL---------ELWNEKSSGKYEKKVYVLPKHLDEKVAALHLEKLGAKL 462 >4MDV-A nrPDB Length = 375 Score = 30.9 bits (68), Expect = 0.92, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 14/35 (40%), Gaps = 1/35 (2%) Query: 28 VSETRLTWPSLTVQWLPTPVQELD-GGFIKQELII 61 V + PSL +WL + L + L+I Sbjct: 283 VLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLI 317 >4YHC-A nrPDB Length = 468 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 23/66 (34%), Gaps = 1/66 (1%) Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 H+ + + S S G D L++WDL+Q + + + + Sbjct: 29 HQLDILKIAVS-ENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 354 SVNDFD 359 V+ F Sbjct: 88 YVSLFS 93 Score = 29.8 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 11/63 (17%), Positives = 20/63 (31%), Gaps = 3/63 (4%) Query: 206 LHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRA--NNTTIDTVKCPQPFNTLAFSHHS 263 H I K F +V D L + D+R + + P+ +A Sbjct: 28 HHQLDILKIAVSENYKT-FASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQG 86 Query: 264 SNL 266 + + Sbjct: 87 NYV 89 >5HQ2-K nrPDB Length = 483 Score = 30.2 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 24/63 (38%), Gaps = 7/63 (11%) Query: 279 YDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAE 338 + L+ + + H + + + + DN+L+ W L Q G +D E Sbjct: 262 FRLKTLDPRPFGLR-HVKYIAS------GENHCFALTKDNKLVSWGLNQFGQCGVSEDVE 314 Query: 339 DGV 341 DG Sbjct: 315 DGA 317 >5GRS-A nrPDB Length = 396 Score = 29.0 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 23/66 (34%), Gaps = 1/66 (1%) Query: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 H+ + + S S G D L++WDL+Q + + + + Sbjct: 29 HQLDILKIAVS-ENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 354 SVNDFD 359 V+ F Sbjct: 88 YVSLFS 93 >3V1X-A nrPDB Length = 461 Score = 28.2 bits (61), Expect = 6.3, Method: Composition-based stats. Identities = 26/164 (15%), Positives = 44/164 (26%), Gaps = 9/164 (5%) Query: 22 PLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEEENYLKFAEINLP 81 P+ + VS W VQ P + GF ++G H ++L A + Sbjct: 153 PVRVEEVSRRIKRWAEDEVQLYPEEWEGQFDGFSVGRYMVGCHPDAPTVDHLMLATRLMV 212 Query: 82 KEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQG 141 E ++ Y + H P A++ Sbjct: 213 AENAVDDC--------YCEDHGGSPVGLGGRLLLAHTAIDHFHSTAEYTPTWQASLAADA 264 Query: 142 TVFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHT 184 Y + G + + Y + L G L G+ T Sbjct: 265 PRRAYDSAMGYFVRAATPSQSDRYRHDMARLHLGYLAEGAWAQT 308 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.305 0.123 0.336 Lambda K H 0.267 0.0381 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,502,817 Number of Sequences: 36641 Number of extensions: 585679 Number of successful extensions: 4362 Number of sequences better than 10.0: 145 Number of HSP's better than 10.0 without gapping: 158 Number of HSP's successfully gapped in prelim test: 97 Number of HSP's that attempted gapping in prelim test: 1326 Number of HSP's gapped (non-prelim): 828 length of query: 401 length of database: 10,336,785 effective HSP length: 99 effective length of query: 302 effective length of database: 6,709,326 effective search space: 2026216452 effective search space used: 2026216452 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.5 bits) S2: 60 (27.8 bits)