BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P39706 (426 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6BX3-B nrPDB 852 0.0 6CHG-D nrPDB 481 e-136 6E29-D nrPDB 191 4e-49 5OV3-A nrPDB 144 1e-34 5NNZ-B nrPDB 56 3e-08 5M25-A nrPDB 56 3e-08 2H9P-A nrPDB 55 7e-08 5WLC-LO nrPDB 54 2e-07 5I2T-A nrPDB 53 2e-07 6EMK-B nrPDB 53 3e-07 6GMH-W nrPDB 52 5e-07 4LG8-A nrPDB 51 8e-07 5Z56-q nrPDB 50 1e-06 6BX3-A nrPDB 50 2e-06 6F3T-A nrPDB 49 4e-06 3JB9-L nrPDB 49 5e-06 6MZM-G nrPDB 49 5e-06 5FVM-C nrPDB 48 6e-06 4OWR-A nrPDB 48 7e-06 3FM0-A nrPDB 48 9e-06 5OPT-p nrPDB 48 9e-06 4V8M-A7 nrPDB 47 2e-05 5FL8-q nrPDB 46 3e-05 3JB9-g nrPDB 45 6e-05 5BPW-A nrPDB 44 1e-04 6HQA-B nrPDB 43 3e-04 5WYJ-BE nrPDB 43 3e-04 3C9C-A nrPDB 42 4e-04 5MZH-A nrPDB 42 6e-04 5WYK-BB nrPDB 42 7e-04 3ACP-A nrPDB 42 7e-04 6QX9-5O nrPDB 41 0.001 1NR0-A nrPDB 41 0.001 5Y1U-A nrPDB 40 0.001 3CFV-B nrPDB 40 0.002 5NZU-C nrPDB 40 0.002 5GAN-H nrPDB 40 0.002 6QX9-4B nrPDB 40 0.003 5Y88-O nrPDB 39 0.004 5BPT-A nrPDB 39 0.005 4XYI-A nrPDB 39 0.005 6N9G-C nrPDB 39 0.005 6EOJ-D nrPDB 39 0.006 4BH6-A nrPDB 38 0.008 5A31-R nrPDB 38 0.009 5WLC-LS nrPDB 38 0.010 6Q8F-A nrPDB 37 0.013 5K19-A nrPDB 37 0.013 4XFV-A nrPDB 37 0.021 3DM0-A nrPDB 36 0.024 5LTD-A nrPDB 36 0.032 5N4A-A nrPDB 36 0.036 5OQL-J nrPDB 36 0.039 4A11-B nrPDB 35 0.046 6G51-g nrPDB 35 0.047 1VYH-C nrPDB 35 0.047 5WLC-LH nrPDB 35 0.055 4V7E-Bg nrPDB 35 0.061 4E5Z-B nrPDB 35 0.062 6J6H-n nrPDB 35 0.068 5OQL-X nrPDB 35 0.070 4V6W-Ag nrPDB 35 0.091 2AQ5-A nrPDB 34 0.12 5WLC-LJ nrPDB 34 0.12 5WBU-D nrPDB 34 0.15 1PI6-A nrPDB 33 0.18 5WLC-LW nrPDB 33 0.19 5G04-R nrPDB 33 0.21 5UZ7-B nrPDB 33 0.26 4N14-A nrPDB 33 0.32 5M89-A nrPDB 33 0.33 4GGA-A nrPDB 33 0.35 6HHQ-h nrPDB 32 0.35 4U1E-I nrPDB 32 0.35 5LCW-Q nrPDB 32 0.37 5OQL-d nrPDB 32 0.49 4BTS-AR nrPDB 32 0.52 6F1U-h nrPDB 32 0.52 5K1B-B nrPDB 32 0.68 2HXV-A nrPDB 32 0.75 2J04-A nrPDB 31 0.84 5WLC-LN nrPDB 31 0.85 2HES-X nrPDB 31 0.86 3JB9-S nrPDB 31 0.90 5XYI-g nrPDB 31 0.93 5WLC-SG nrPDB 31 1.2 6CHG-A nrPDB 31 1.3 6QDV-o nrPDB 31 1.3 4J0X-A nrPDB 30 1.4 2X26-A nrPDB 30 1.6 5YZG-W nrPDB 30 1.6 5K0Y-T nrPDB 30 1.6 3JAP-g nrPDB 30 1.6 6N8P-A nrPDB 30 2.2 3DW8-B nrPDB 30 2.5 5L9T-R nrPDB 29 3.1 5K1H-B nrPDB 29 3.2 4AV8-A nrPDB 28 5.1 5OQJ-7 nrPDB 28 5.4 5SVA-Z nrPDB 28 5.5 5CWW-B nrPDB 28 5.9 5AJA-A nrPDB 28 7.5 5OQL-L nrPDB 28 7.6 4J0W-A nrPDB 28 7.6 3IYO-A nrPDB 28 7.6 5Z57-K nrPDB 28 7.9 3JZG-A nrPDB 28 8.0 3M6A-A nrPDB 28 8.4 2ZZQ-A nrPDB 28 8.6 4AEZ-A nrPDB 28 8.8 3I2N-A nrPDB 28 9.0 >6BX3-B nrPDB Length = 412 Score = 852 bits (2202), Expect = 0.0, Method: Compositional matrix adjust. Identities = 412/412 (100%), Positives = 412/412 (100%) Query: 2 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI 61 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI Sbjct: 1 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI 60 Query: 62 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ Sbjct: 61 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 120 Query: 122 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 181 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP Sbjct: 121 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 180 Query: 182 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY Sbjct: 181 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 240 Query: 242 EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS 301 EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS Sbjct: 241 EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS 300 Query: 302 GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEEN 361 GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEEN Sbjct: 301 GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEEN 360 Query: 362 VDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERFTI 413 VDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERFTI Sbjct: 361 VDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERFTI 412 >6CHG-D nrPDB Length = 439 Score = 481 bits (1238), Expect = e-136, Method: Compositional matrix adjust. Identities = 234/433 (54%), Positives = 313/433 (72%), Gaps = 13/433 (3%) Query: 2 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI 61 N+LLQDPF VLKE+PEKLTHT+E P+ C++FSP GDYLA+GC+NGA++IYDMD+ +PI Sbjct: 3 NLLLQDPFGVLKEYPEKLTHTLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPI 62 Query: 62 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 + G GAH R + S+ WS DGR L +S RDW KLWD+++P+K ++ +FD P+W C Sbjct: 63 AMLGTHSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCH 122 Query: 122 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 181 + + +C+ T+ EE AYV+ + D + +Q HGY LV H Sbjct: 123 VV--RWNVCIVTVVEEPTAYVLTLT-DRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIE 179 Query: 182 NIIIVGTSKGWLDFYKF--HSLYQTE--CIHSLKITSSNIKHLIVSQNGERLAINCSDRT 237 +III GTSKGW++ ++ S ++ + C + KI ++NIK +I+S +G R+AIN SDRT Sbjct: 180 SIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRT 239 Query: 238 IRQYEISIDDENS------AVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSA 291 IRQY++ ++D S +V + LEHKYQD+IN+LQWN I FSN++ EYLVAS HGSSA Sbjct: 240 IRQYQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSA 299 Query: 292 HELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSAL 351 H+LY+WET+SG+LVRVLEGA+EEL+DI+W+FYSM I SNGFESG VY+WS+VIPPKWSAL Sbjct: 300 HDLYLWETSSGSLVRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMWSIVIPPKWSAL 359 Query: 352 APDFEEVEENVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERF 411 APDFEEVEEN+DY EKE+EFD +D+ Q + + EEIAIDL T E+YDVRGN++ + F Sbjct: 360 APDFEEVEENIDYQEKENEFDIMDDDNNLQAMTEAEEIAIDLCTPEKYDVRGNDISMPSF 419 Query: 412 TIPTDYTRIIKMQ 424 IP DY +I Q Sbjct: 420 VIPIDYEGVIIQQ 432 >6E29-D nrPDB Length = 345 Score = 191 bits (486), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 121/357 (33%), Positives = 198/357 (55%), Gaps = 29/357 (8%) Query: 1 MNILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRP 60 MN+LL D + +L+++PE +T+TI + T C++F+ GD+LA G +G +VI+D++T Sbjct: 2 MNLLLSDDY-LLQDYPENITNTIRSGHST-CVRFNRKGDFLASGRVDGTVVIWDLETMGV 59 Query: 61 ICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGC 120 L H + ITS++WS GR LL++ + W + LWDL + K +E+RF +P++G Sbjct: 60 ----ARKLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDL-QDGKRYREVRFRAPVYGA 114 Query: 121 QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHG----------- 169 + A +FE+ ++D + + S K+ S+ D Sbjct: 115 ELHPWNHHQFAAALFEDQ-PMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAK 173 Query: 170 YVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERL 229 ++ V+T + ++ GT+KG L+ + E I+S KI S I L ++++G L Sbjct: 174 HMTTAIVYTASGDHLLAGTTKGRLNIIDART---REIIYSEKIASGIITTLRLTESGREL 230 Query: 230 AINCSDRTIRQYEI----SIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVAS 285 +N DR IR + + + D + ++L LEHK+QDV+N+L WN + FS T EY+ AS Sbjct: 231 LVNAQDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSA-TGEYVAAS 289 Query: 286 THGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 T+ + HELYIWE G+LVR+LEG +EE I W + + + G E+G + +WSV Sbjct: 290 TYNN--HELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSV 344 >5OV3-A nrPDB Length = 381 Score = 144 bits (362), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 121/404 (29%), Positives = 192/404 (47%), Gaps = 40/404 (9%) Query: 2 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI 61 N+ L + F + +PE+ T++ F+ G LA+GC +G +VI+D T R I Sbjct: 3 NLELLESFG--QNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLT-RGI 59 Query: 62 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 ++ AH+ P+ S+ WS DG L+++S D + WD+ + RF SPI Q Sbjct: 60 ---AKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCD-QRFRFPSPILKVQ 115 Query: 122 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 181 + +++ V + PV LS S L D +V + + Sbjct: 116 YHPR----------DQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFD-RRG 164 Query: 182 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSN-----IKHLIVSQNGERLAINCSDR 236 I G +KG + K S + + S ++T+ IK + ++ G IN +DR Sbjct: 165 EYIYTGNAKGKILVLKTDS---QDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADR 221 Query: 237 TIRQY---EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHE 293 IR Y EI + E K QD++N+ W FS + EY+VA + + H Sbjct: 222 IIRVYDGREILTCGRDGEPEPM--QKLQDLVNRTPWKKCCFSGD-GEYIVAGS--ARQHA 276 Query: 294 LYIWETTSGTLVRVLEGAEEELI-DINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALA 352 LYIWE + G LV++L G EL+ D+ W + + + SG V +W+ WSA A Sbjct: 277 LYIWEKSIGNLVKILHGTRGELLLDVAW--HPVRPIIASISSGVVSIWAQNQVENWSAFA 334 Query: 353 PDFEEVEENVDYLEKEDEFDEVDEAE---QQQGLEQEEEIAIDL 393 PDF+E++ENV+Y E+E EFD DE + +Q G + E+ +D+ Sbjct: 335 PDFKELDENVEYEERESEFDIEDEDKSEPKQTGADAAEDEEVDV 378 >5NNZ-B nrPDB Length = 415 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 59/282 (20%), Positives = 108/282 (38%), Gaps = 40/282 (14%) Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 +L AH+ P+T++A + G +T S D + KLWD + + L+ Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEE-------------LNTLEGH 133 Query: 127 RRLCVATIFEESDA-YVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 R + A F + S D L S K + H +VC ++ Sbjct: 134 RNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVA 193 Query: 186 VG----TSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 G T+K W + E +++L+ S+ I L + +G+R+ D T+ + Sbjct: 194 TGSMDTTAKLW-------DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246 Query: 242 EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS 301 + D V + + H + W+C L GS +W+ T+ Sbjct: 247 DA---DTGRKVNILIGHCAEISSASFNWDCSLILT-----------GSMDKTCKLWDATN 292 Query: 302 GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 343 G V L G ++E++D +D Y+ +++ G ++S Sbjct: 293 GKCVATLTGHDDEILDSCFD-YTGKLIATASADGTARIFSAA 333 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/137 (26%), Positives = 59/137 (43%), Gaps = 17/137 (12%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 L F+ GD + G + +V++D DT R + N+L H I+S +++ D L+LT S Sbjct: 225 LSFNTSGDRIITGSFDHTVVVWDADTGRKV----NILIGHCAEISSASFNWDCSLILTGS 280 Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVA 151 D + KLWD + D I LD+ F+ + + S D A Sbjct: 281 MDKTCKLWDATNGKCVATLTGHDDEI-----LDS--------CFDYTGKLIATASADGTA 327 Query: 152 SLLSKSDEKQLSSTPDH 168 + S + K ++ H Sbjct: 328 RIFSAATRKCIAKLEGH 344 Score = 36.2 bits (82), Expect = 0.026, Method: Compositional matrix adjust. Identities = 56/306 (18%), Positives = 115/306 (37%), Gaps = 35/306 (11%) Query: 35 SPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDW 94 +P GD +A G + ++ ++T + + H I ++++P L+ T S D Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCY----HTFRGHTAEIVCLSFNPQSTLVATGSMDT 199 Query: 95 SIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLL 154 + KLWD+ + + I ++ F S +I S D + Sbjct: 200 TAKLWDIQNGEEVYTLRGHSAEI-------------ISLSFNTSGDRIITGSFDHTVVVW 246 Query: 155 SKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITS 214 ++++ H + ++I+ G+ K +C+ +L Sbjct: 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD---KTCKLWDATNGKCVATLTGHD 303 Query: 215 SNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILF 274 I G+ +A +D T R + + + +E ++ I+K+ +N Sbjct: 304 DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLE-----GHEGEISKISFN---- 354 Query: 275 SNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFES 334 +L+ GSS IW+ +G ++VLEG +E+ ++ Y +IV G + Sbjct: 355 --PQGNHLLT---GSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKGNIVITGSKD 408 Query: 335 GNVYVW 340 +W Sbjct: 409 NTCRIW 414 Score = 35.4 bits (80), Expect = 0.045, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 4/67 (5%) Query: 34 FSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRD 93 F G +A A+G I+ T + I L H I+ I+++P G LLT S D Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIA----KLEGHEGEISKISFNPQGNHLLTGSSD 366 Query: 94 WSIKLWD 100 + ++WD Sbjct: 367 KTARIWD 373 Score = 34.7 bits (78), Expect = 0.083, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 37/68 (54%), Gaps = 4/68 (5%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 + F+P G++L G ++ I+D T + + +L H I S A++ G +++T S Sbjct: 351 ISFNPQGNHLLTGSSDKTARIWDAQTGQCL----QVLEGHTDEIFSCAFNYKGNIVITGS 406 Query: 92 RDWSIKLW 99 +D + ++W Sbjct: 407 KDNTCRIW 414 >5M25-A nrPDB Length = 434 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 71/290 (24%), Positives = 128/290 (44%), Gaps = 40/290 (13%) Query: 32 LQFSPCGDYLALGCANGALVIYDM-DTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 ++FSP G++LA A+ + I+ D + G+ LG I+ +AWS D LL+++ Sbjct: 151 VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG-----ISDVAWSSDSNLLVSA 205 Query: 91 SRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPV 150 S D ++K+WD+S K LK ++ S C + + L V+ F+ES Sbjct: 206 SDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES------------ 252 Query: 151 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL 210 + K L + P H V VH +IV +S + + +C+ +L Sbjct: 253 VRIWDVKTGKCLKTLPAHSDP-VSAVHFNRDGSLIVSSS--YDGLCRIWDTASGQCLKTL 309 Query: 211 KITSSN--IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQ 268 I N + + S NG+ + D T++ ++ S + ++ HK + Sbjct: 310 -IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS---KGKCLKTYTGHKNEKY----- 360 Query: 269 WNCIL--FSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELI 316 CI FS +++V+ GS + +YIW + +V+ L+G + +I Sbjct: 361 --CIFANFSVTGGKWIVS---GSEDNLVYIWNLQTKEIVQKLQGHTDVVI 405 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 58/286 (20%), Positives = 120/286 (41%), Gaps = 49/286 (17%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKR 127 L H + ++S+ +SP+G L +SS D IK+W + +F+ I G Sbjct: 141 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-------DGKFEKTISG-------H 186 Query: 128 RLCVATIFEESDA-YVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 186 +L ++ + SD+ ++ S+D + S K L + H + C N+I+ Sbjct: 187 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 246 Query: 187 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS-- 244 G+ + + + + +C+ +L S + + +++G + + D R ++ + Sbjct: 247 GS---FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 303 Query: 245 ------IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 298 IDD+N V + FS N +Y++A+T ++ L +W+ Sbjct: 304 QCLKTLIDDDNPPVSF-----------------VKFSPN-GKYILAATLDNT---LKLWD 342 Query: 299 TTSGTLVRVLEGAEEE--LIDINWDFYSMSIVSNGFESGNVYVWSV 342 + G ++ G + E I N+ + +G E VY+W++ Sbjct: 343 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 388 >2H9P-A nrPDB Length = 329 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 71/290 (24%), Positives = 128/290 (44%), Gaps = 40/290 (13%) Query: 32 LQFSPCGDYLALGCANGALVIYDM-DTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 ++FSP G++LA A+ + I+ D + G+ LG I+ +AWS D LL+++ Sbjct: 46 VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG-----ISDVAWSSDSNLLVSA 100 Query: 91 SRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPV 150 S D ++K+WD+S K LK ++ S C + + L V+ F+ES Sbjct: 101 SDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES------------ 147 Query: 151 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL 210 + K L + P H V VH +IV +S + + +C+ +L Sbjct: 148 VRIWDVKTGKCLKTLPAHSDP-VSAVHFNRDGSLIVSSS--YDGLCRIWDTASGQCLKTL 204 Query: 211 KITSSN--IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQ 268 I N + + S NG+ + D T++ ++ S + ++ HK + Sbjct: 205 -IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS---KGKCLKTYTGHKNEKY----- 255 Query: 269 WNCIL--FSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELI 316 CI FS +++V+ GS + +YIW + +V+ L+G + +I Sbjct: 256 --CIFANFSVTGGKWIVS---GSEDNLVYIWNLQTKEIVQKLQGHTDVVI 300 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/286 (20%), Positives = 120/286 (41%), Gaps = 49/286 (17%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKR 127 L H + ++S+ +SP+G L +SS D IK+W + +F+ I G Sbjct: 36 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-------AYDGKFEKTISG-------H 81 Query: 128 RLCVATIFEESDA-YVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 186 +L ++ + SD+ ++ S+D + S K L + H + C N+I+ Sbjct: 82 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 141 Query: 187 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS-- 244 G+ + + + + +C+ +L S + + +++G + + D R ++ + Sbjct: 142 GS---FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 198 Query: 245 ------IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 298 IDD+N V + FS N +Y++A+T ++ L +W+ Sbjct: 199 QCLKTLIDDDNPPVSF-----------------VKFSPN-GKYILAATLDNT---LKLWD 237 Query: 299 TTSGTLVRVLEGAEEE--LIDINWDFYSMSIVSNGFESGNVYVWSV 342 + G ++ G + E I N+ + +G E VY+W++ Sbjct: 238 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 283 >5WLC-LO nrPDB Length = 923 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 69/340 (20%), Positives = 134/340 (39%), Gaps = 44/340 (12%) Query: 28 RTECLQFSPCGDYLALGCANGALVIYDMDT-----FRPICVPGNMLGAHVRPITSIAWSP 82 + ++FSP G AL + D F P V + H + ITS+ WS Sbjct: 98 KCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPF-VRHRVHAGHFQDITSLTWSQ 156 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP---IWGCQWLDAKRRLCVATIFEESD 139 D R +LT+S+D S K+W + K L F+ + G + + + + T+ ++ Sbjct: 157 DSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEK--IYTVSKDGA 214 Query: 140 AYVIDFSNDP------VASLLSKSDEKQLSS-----TPDHGYV-----LVCTVHTKHPNI 183 +V +F+ P + K +E +S T H + + C + Sbjct: 215 VFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRL 274 Query: 184 IIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 + VG + G ++ + L I L + + + + V+Q GE LA S + ++ Sbjct: 275 LAVGFTSGE---FRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS----KLGQL 327 Query: 244 SIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGT 303 + + S + + + D N L +S + + + AS G ++ +W+ TSG Sbjct: 328 LVYEWQSESYILKQQGHFDSTNSLA-----YSPDGSRVVTASEDG----KIKVWDITSGF 378 Query: 304 LVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 343 + E + + + + S+ + G V W ++ Sbjct: 379 CLATFEEHTSSVTAVQFAKRGQVMFSSSLD-GTVRAWDLI 417 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/117 (24%), Positives = 44/117 (37%), Gaps = 39/117 (33%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI-----------CVPGNMLG---- 69 N + +C+ F P LA+G +G +YD+ F I V N G Sbjct: 259 NQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLA 318 Query: 70 ------------------------AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 H S+A+SPDG ++T+S D IK+WD++ Sbjct: 319 FGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDIT 375 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 27/118 (22%), Positives = 57/118 (48%), Gaps = 9/118 (7%) Query: 20 THTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA---HVRPIT 76 T T ++ CL P G+ + CA G+L +D+ + G +L A H P++ Sbjct: 424 TFTGTERIQFNCLAVDPSGEVV---CA-GSLDNFDIHVWS--VQTGQLLDALSGHEGPVS 477 Query: 77 SIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATI 134 +++S + +L ++S D +I++W + S+ ++ I S + + + V+T+ Sbjct: 478 CLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTL 535 >5I2T-A nrPDB Length = 742 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 69/340 (20%), Positives = 134/340 (39%), Gaps = 44/340 (12%) Query: 28 RTECLQFSPCGDYLALGCANGALVIYDMDT-----FRPICVPGNMLGAHVRPITSIAWSP 82 + ++FSP G AL + D F P V + H + ITS+ WS Sbjct: 123 KCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPF-VRHRVHAGHFQDITSLTWSQ 181 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP---IWGCQWLDAKRRLCVATIFEESD 139 D R +LT+S+D S K+W + K L F+ + G + + + + T+ ++ Sbjct: 182 DSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEK--IYTVSKDGA 239 Query: 140 AYVIDFSNDP------VASLLSKSDEKQLSS-----TPDHGYV-----LVCTVHTKHPNI 183 +V +F+ P + K +E +S T H + + C + Sbjct: 240 VFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRL 299 Query: 184 IIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 + VG + G ++ + L I L + + + + V+Q GE LA S + ++ Sbjct: 300 LAVGFTSGE---FRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS----KLGQL 352 Query: 244 SIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGT 303 + + S + + + D N L +S + + + AS G ++ +W+ TSG Sbjct: 353 LVYEWQSESYILKQQGHFDSTNSLA-----YSPDGSRVVTASEDG----KIKVWDITSGF 403 Query: 304 LVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 343 + E + + + + S+ + G V W ++ Sbjct: 404 CLATFEEHTSSVTAVQFAKRGQVMFSSSLD-GTVRAWDLI 442 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 29/117 (24%), Positives = 44/117 (37%), Gaps = 39/117 (33%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI-----------CVPGNMLG---- 69 N + +C+ F P LA+G +G +YD+ F I V N G Sbjct: 284 NQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLA 343 Query: 70 ------------------------AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 H S+A+SPDG ++T+S D IK+WD++ Sbjct: 344 FGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDIT 400 Score = 33.1 bits (74), Expect = 0.24, Method: Compositional matrix adjust. Identities = 27/118 (22%), Positives = 57/118 (48%), Gaps = 9/118 (7%) Query: 20 THTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA---HVRPIT 76 T T ++ CL P G+ + CA G+L +D+ + G +L A H P++ Sbjct: 449 TFTGTERIQFNCLAVDPSGEVV---CA-GSLDNFDIHVWS--VQTGQLLDALSGHEGPVS 502 Query: 77 SIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATI 134 +++S + +L ++S D +I++W + S+ ++ I S + + + V+T+ Sbjct: 503 CLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTL 560 >6EMK-B nrPDB Length = 303 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 69/283 (24%), Positives = 118/283 (41%), Gaps = 61/283 (21%) Query: 52 IYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI 111 +YD+ T P P H +TS+++ D R ++TSS D +IK+WD+ PS P + Sbjct: 57 LYDIRTTNP--NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIP-RNY 113 Query: 112 RFDSPI------------------WGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL 153 + ++P+ + D C + E D + S S+ Sbjct: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 Query: 154 LSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKIT 213 L+ ++ K + YV HT ++ V ++ HS Y T + Sbjct: 174 LAAANTK------GNCYVWEMPNHTDASHLKPVTK-------FRAHSTYITRI-----LL 215 Query: 214 SSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCIL 273 SS++KH LA +D T R + I D++ +E TL D + W+C Sbjct: 216 SSDVKH---------LATCSADHTARVWSI---DDDFKLETTL-----DGHQRWVWDCA- 257 Query: 274 FSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELI 316 FS ++A YLV + SS H + +W+ ++ +VR G + + Sbjct: 258 FSADSA-YLVTA---SSDHYVRLWDLSTREIVRQYGGHHKGAV 296 >6GMH-W nrPDB Length = 305 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 4/70 (5%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 + +SP G YLA G +G + I+D+ T + + + L H PI S+ +SPD +LL+T+S Sbjct: 154 IAYSPDGKYLASGAIDGIINIFDIATGKLL----HTLEGHAMPIRSLTFSPDSQLLVTAS 209 Query: 92 RDWSIKLWDL 101 D IK++D+ Sbjct: 210 DDGYIKIYDV 219 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 4/89 (4%) Query: 14 EHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 E+ +++ P+ L FSP YLA G G + I+ +++ + L + Sbjct: 94 ENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY----SLDTRGK 149 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 I SIA+SPDG+ L + + D I ++D++ Sbjct: 150 FILSIAYSPDGKYLASGAIDGIINIFDIA 178 >4LG8-A nrPDB Length = 354 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 32/86 (37%), Positives = 45/86 (52%), Gaps = 7/86 (8%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPIC-VPGNMLGAHVRPITSIAWSPDGRLLLT 89 C QF P G G + + I+D+ + PG H PITSIA+S +G L T Sbjct: 205 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-----HSGPITSIAFSENGYYLAT 259 Query: 90 SSRDWSIKLWDLSKPSKPLKEIRFDS 115 ++ D S+KLWDL K K K ++ D+ Sbjct: 260 AADDSSVKLWDLRKL-KNFKTLQLDN 284 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 41/202 (20%), Positives = 81/202 (40%), Gaps = 22/202 (10%) Query: 44 GCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSK 103 G A+ +V++D + + + L H + +TS+ + P L+ ++S D +I++W + Sbjct: 90 GGADKNVVVFDKSSEQILAT----LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV-- 143 Query: 104 PSKPLKEIRFDSPIWGC-QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQL 162 P C Q + A + Y++ S+D + + L Sbjct: 144 ------------PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVL 191 Query: 163 SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDF-YKFHSLYQTECIHSLKITSSNIKHLI 221 + D T HP+ +I GT G +D K L + + + S I + Sbjct: 192 TKVTDETSGCSLTCAQFHPDGLIFGT--GTMDSQIKIWDLKERTNVANFPGHSGPITSIA 249 Query: 222 VSQNGERLAINCSDRTIRQYEI 243 S+NG LA D +++ +++ Sbjct: 250 FSENGYYLATAADDSSVKLWDL 271 >5Z56-q nrPDB Length = 504 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 32/86 (37%), Positives = 45/86 (52%), Gaps = 7/86 (8%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPIC-VPGNMLGAHVRPITSIAWSPDGRLLLT 89 C QF P G G + + I+D+ + PG H PITSIA+S +G L T Sbjct: 355 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-----HSGPITSIAFSENGYYLAT 409 Query: 90 SSRDWSIKLWDLSKPSKPLKEIRFDS 115 ++ D S+KLWDL K K K ++ D+ Sbjct: 410 AADDSSVKLWDLRK-LKNFKTLQLDN 434 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 41/202 (20%), Positives = 81/202 (40%), Gaps = 22/202 (10%) Query: 44 GCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSK 103 G A+ +V++D + + + L H + +TS+ + P L+ ++S D +I++W + Sbjct: 240 GGADKNVVVFDKSSEQILAT----LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV-- 293 Query: 104 PSKPLKEIRFDSPIWGC-QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQL 162 P C Q + A + Y++ S+D + + L Sbjct: 294 ------------PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVL 341 Query: 163 SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDF-YKFHSLYQTECIHSLKITSSNIKHLI 221 + D T HP+ +I GT G +D K L + + + S I + Sbjct: 342 TKVTDETSGCSLTCAQFHPDGLIFGT--GTMDSQIKIWDLKERTNVANFPGHSGPITSIA 399 Query: 222 VSQNGERLAINCSDRTIRQYEI 243 S+NG LA D +++ +++ Sbjct: 400 FSENGYYLATAADDSSVKLWDL 421 >6BX3-A nrPDB Length = 314 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 26/79 (32%), Positives = 47/79 (59%), Gaps = 4/79 (5%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 +N L+ C + SP G +LA+ ++IYD++ V ++ +H RP + + WSPD Sbjct: 10 QNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRT---VSQTLVTSHARPFSELCWSPD 65 Query: 84 GRLLLTSSRDWSIKLWDLS 102 G+ + T+S D+S+++ LS Sbjct: 66 GQCIATASDDFSVEIIHLS 84 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 12/29 (41%), Positives = 18/29 (62%) Query: 72 VRPITSIAWSPDGRLLLTSSRDWSIKLWD 100 V PI+ + +S + R LL S D +K+WD Sbjct: 188 VVPISQVKFSENARYLLVKSLDGVVKIWD 216 Score = 27.7 bits (60), Expect = 8.9, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 13/79 (16%) Query: 272 ILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRV--LEGAEEELI--DINWDFY---- 323 + FS N LV S G + IW+ G +VR ++ E+ ++ DF Sbjct: 194 VKFSENARYLLVKSLDGV----VKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 249 Query: 324 -SMSIVSNGFESGNVYVWS 341 S +V +G+E+G++Y W+ Sbjct: 250 GSTPLVISGYENGDIYCWN 268 >6F3T-A nrPDB Length = 608 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 24/72 (33%), Positives = 39/72 (54%), Gaps = 4/72 (5%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 C +F P +Y+A G A+ + ++D+ CV + H PI S+ +SP+GR L T Sbjct: 440 CTRFHPNSNYVATGSADRTVRLWDV--LNGNCV--RIFTGHKGPIHSLTFSPNGRFLATG 495 Query: 91 SRDWSIKLWDLS 102 + D + LWD+ Sbjct: 496 ATDGRVLLWDIG 507 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/178 (21%), Positives = 68/178 (38%), Gaps = 16/178 (8%) Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 +L H P+ ++SPD LL+SS D +++LW L + + + P+W Q Sbjct: 346 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQ----- 400 Query: 127 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 186 F Y + +D VA L + + L H + CT + N + Sbjct: 401 --------FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVAT 452 Query: 187 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 244 G++ + + + C+ I L S NG LA +D + ++I Sbjct: 453 GSADRTVRLW---DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 507 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/114 (27%), Positives = 54/114 (47%), Gaps = 10/114 (8%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLG---AHVRPITSIAWSPDGRLLL 88 L FSP G +LA G +G ++++D+ G M+G H + S+ +S DG +L Sbjct: 483 LTFSPNGRFLATGATDGRVLLWDIGH-------GLMVGELKGHTDTVCSLRFSRDGEILA 535 Query: 89 TSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 + S D +++LWD K + L+ F + + + L + T +S V Sbjct: 536 SGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVV 589 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 17/69 (24%), Positives = 33/69 (47%), Gaps = 4/69 (5%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 QFSP G Y G + ++ D ++P+ + H+ + + P+ + T S Sbjct: 400 QFSPYGYYFVSGGHDRVARLWATDHYQPL----RIFAGHLADVNCTRFHPNSNYVATGSA 455 Query: 93 DWSIKLWDL 101 D +++LWD+ Sbjct: 456 DRTVRLWDV 464 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 77/207 (37%), Gaps = 22/207 (10%) Query: 34 FSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRD 93 FSP +YL +G + ++ + TF C+ G H P+ +SP G ++ D Sbjct: 359 FSPDRNYLLSSSEDGTVRLWSLQTF--TCLVG--YKGHNYPVWDTQFSPYGYYFVSGGHD 414 Query: 94 WSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL 153 +LW + +PL+ I+ D T F + YV S D L Sbjct: 415 RVARLW-ATDHYQPLR-------IFAGHLADVN-----CTRFHPNSNYVATGSADRTVRL 461 Query: 154 LSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKF-HSLYQTECIHSLKI 212 + + H + + + + G + G + + H L E LK Sbjct: 462 WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE----LKG 517 Query: 213 TSSNIKHLIVSQNGERLAINCSDRTIR 239 + + L S++GE LA D T+R Sbjct: 518 HTDTVCSLRFSRDGEILASGSMDNTVR 544 >3JB9-L nrPDB Length = 340 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 66/291 (22%), Positives = 115/291 (39%), Gaps = 28/291 (9%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 +F P G Y A G + ++++++ F + G + G IT + WS D R++ SS Sbjct: 57 RFDPSGSYFASGGMDRQILLWNV--FGDVKNYGVLNGCK-GAITDLQWSRDSRVVYCSSS 113 Query: 93 DWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 D + WD K K + L L + ++ ++ V D Sbjct: 114 DTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSEL-LTSVSDDCTMKVWD-------- 164 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKI 212 S K T + Y L + + +G G + K L C H LK Sbjct: 165 ----SRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAI---KIWDLRNNHCSHVLKG 217 Query: 213 TSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCI 272 I L +S++G L N D T+R +++ ++ + L+ ++ I+ + N + Sbjct: 218 HKDIITSLAISKDGSSLLSNSMDNTVRIFDVK---PFASAQRQLQ-IFEGAIHGQEHNLL 273 Query: 273 LFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFY 323 + + V + GSS +Y+W T G L VL G E + + DF+ Sbjct: 274 GVAWSRNSRFVGA--GSSDKNVYVWSAT-GDLRYVLPGHEGSVNHV--DFH 319 >6MZM-G nrPDB Length = 800 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 24/72 (33%), Positives = 39/72 (54%), Gaps = 4/72 (5%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 C +F P +Y+A G A+ + ++D+ CV + H PI S+ +SP+GR L T Sbjct: 632 CTRFHPNSNYVATGSADRTVRLWDV--LNGNCV--RIFTGHKGPIHSLTFSPNGRFLATG 687 Query: 91 SRDWSIKLWDLS 102 + D + LWD+ Sbjct: 688 ATDGRVLLWDIG 699 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 68/179 (37%), Gaps = 16/179 (8%) Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 +L H P+ ++SPD LL+SS D +++LW L + + + P+W Q Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQ---- 592 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 F Y + +D VA L + + L H + CT + N + Sbjct: 593 ---------FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 244 G++ + + + C+ I L S NG LA +D + ++I Sbjct: 644 TGSADRTVRLW---DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG 699 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/114 (27%), Positives = 54/114 (47%), Gaps = 10/114 (8%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLG---AHVRPITSIAWSPDGRLLL 88 L FSP G +LA G +G ++++D+ G M+G H + S+ +S DG +L Sbjct: 675 LTFSPNGRFLATGATDGRVLLWDIGH-------GLMVGELKGHTDTVCSLRFSRDGEILA 727 Query: 89 TSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 + S D +++LWD K + L+ F + + + L + T +S V Sbjct: 728 SGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVV 781 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 17/69 (24%), Positives = 33/69 (47%), Gaps = 4/69 (5%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 QFSP G Y G + ++ D ++P+ + H+ + + P+ + T S Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPL----RIFAGHLADVNCTRFHPNSNYVATGSA 647 Query: 93 DWSIKLWDL 101 D +++LWD+ Sbjct: 648 DRTVRLWDV 656 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 77/207 (37%), Gaps = 22/207 (10%) Query: 34 FSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRD 93 FSP +YL +G + ++ + TF C+ G H P+ +SP G ++ D Sbjct: 551 FSPDRNYLLSSSEDGTVRLWSLQTF--TCLVG--YKGHNYPVWDTQFSPYGYYFVSGGHD 606 Query: 94 WSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL 153 +LW + +PL+ I+ D T F + YV S D L Sbjct: 607 RVARLW-ATDHYQPLR-------IFAGHLADVN-----CTRFHPNSNYVATGSADRTVRL 653 Query: 154 LSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKF-HSLYQTECIHSLKI 212 + + H + + + + G + G + + H L E LK Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE----LKG 709 Query: 213 TSSNIKHLIVSQNGERLAINCSDRTIR 239 + + L S++GE LA D T+R Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVR 736 >5FVM-C nrPDB Length = 303 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 60/268 (22%), Positives = 120/268 (44%), Gaps = 31/268 (11%) Query: 52 IYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI 111 +YD+ + P P + H +TSIA+ + R +++SS D +IK+WD+ PS + Sbjct: 57 LYDIRSNNP--NPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQ-RNY 113 Query: 112 RFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYV 171 + ++P+ + L + ++ + + D + + L+ D L S Sbjct: 114 KHNAPVNEVAIHPNQGELI--SCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSV---- 167 Query: 172 LVCTVHTKHPNIIIVGTSKGWLDFYKF--HSLYQT-ECIHSLKITSSNIKHLIVSQNGER 228 ++++ G +KG ++ H+ T E + K + I +++S + + Sbjct: 168 ------ASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN 221 Query: 229 LAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHG 288 LA +D T R + I ++N +E TL D + W+C FS ++A YLV + Sbjct: 222 LATCSADHTARVWNI---EDNYQLETTL-----DGHQRWVWDCA-FSADSA-YLVTAC-- 269 Query: 289 SSAHELYIWETTSGTLVRVLEGAEEELI 316 S H + +W+ ++ +VR G + + Sbjct: 270 -SDHYVRLWDLSTSEIVRQYGGHHKGAV 296 >4OWR-A nrPDB Length = 339 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 34/107 (31%), Positives = 52/107 (48%), Gaps = 8/107 (7%) Query: 31 CLQFSPC---GDYLALGC-ANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRL 86 CL FSP G++L G AN D+ + I M H P+ + WS DG Sbjct: 15 CLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM---HTGPVLDVCWSDDGSK 71 Query: 87 LLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + T+S D + K+WDLS ++ ++ + D+P+ W+ A CV T Sbjct: 72 VFTASCDKTAKMWDLSS-NQAIQIAQHDAPVKTIHWIKAPNYSCVMT 117 >3FM0-A nrPDB Length = 345 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 25/70 (35%), Positives = 38/70 (54%), Gaps = 2/70 (2%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 + +SPCG+YLA + I+ + CV L H + S+AW+P G LL T S Sbjct: 67 VAWSPCGNYLASASFDATTCIWKKNQDDFECV--TTLEGHENEVKSVAWAPSGNLLATCS 124 Query: 92 RDWSIKLWDL 101 RD S+ +W++ Sbjct: 125 RDKSVWVWEV 134 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 32/172 (18%), Positives = 65/172 (37%), Gaps = 12/172 (6%) Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 +AW+P G LL + D I++W S K + + +R + Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSE----------GHQRTVRKVAWSP 71 Query: 138 SDAYVIDFSNDPVASLLSKS--DEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDF 195 Y+ S D + K+ D + +++ H + N++ + + Sbjct: 72 CGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWV 131 Query: 196 YKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDD 247 ++ + EC+ L + ++KH++ + E LA D T++ Y DD Sbjct: 132 WEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDD 183 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 19/76 (25%), Positives = 43/76 (56%), Gaps = 5/76 (6%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI-CVPGNMLGAHVRPITSIAWSP 82 EN +++ + ++P G+ LA + ++ ++++D CV ++L +H + + + W P Sbjct: 105 ENEVKS--VAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV--SVLNSHTQDVKHVVWHP 160 Query: 83 DGRLLLTSSRDWSIKL 98 LL ++S D ++KL Sbjct: 161 SQELLASASYDDTVKL 176 >5OPT-p nrPDB Length = 318 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 41/152 (26%), Positives = 71/152 (46%), Gaps = 13/152 (8%) Query: 21 HTIENPLRTE---CLQFSPCGD--YLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 HT+ T+ C++FSP + + G + + ++D+ + R + L H I Sbjct: 144 HTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLL----TDLKGHTNYI 199 Query: 76 TSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIF 135 TS+ SPDG L +S +D +LWDL+K + L E+ +PI + + +C AT Sbjct: 200 TSVTVSPDGSLCASSDKDGVARLWDLTK-GEALSEMAAGAPINQICFSPNRYWMCAAT-- 256 Query: 136 EESDAYVIDFSNDPVASLLSKSDEKQLSSTPD 167 E + D N V L+ +++ TP+ Sbjct: 257 -EKGIRIFDLENKDVIVELAPEAQQKSKKTPE 287 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 17/70 (24%), Positives = 39/70 (55%), Gaps = 4/70 (5%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 + S GD+ + +L ++++ T +C LG H + + S+ +SPD R +++ Sbjct: 73 VALSNNGDFAVSASWDHSLRLWNLQT--GVC-QHKFLG-HTKDVLSVTFSPDNRQIVSGG 128 Query: 92 RDWSIKLWDL 101 RD ++++W++ Sbjct: 129 RDNALRVWNV 138 >4V8M-A7 nrPDB Length = 318 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 38/132 (28%), Positives = 62/132 (46%), Gaps = 13/132 (9%) Query: 21 HTIENPLRTE---CLQFSPCGD--YLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 HT+ T+ C++FSP D + G + + ++D+ T R + L H + Sbjct: 144 HTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLV----TDLKGHTNYV 199 Query: 76 TSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIF 135 TS+ SPDG L +S +D +LWDL+K + L E+ +PI + + +C AT Sbjct: 200 TSVTVSPDGSLCASSDKDGVARLWDLTK-GEALSEMAAGAPINQICFSPNRYWMCAAT-- 256 Query: 136 EESDAYVIDFSN 147 E + D N Sbjct: 257 -EKGIRIFDLEN 267 Score = 31.6 bits (70), Expect = 0.65, Method: Compositional matrix adjust. Identities = 10/32 (31%), Positives = 23/32 (71%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDL 101 H + + S+A+SPD R +++ RD ++++W++ Sbjct: 107 GHTKDVLSVAFSPDNRQIVSGGRDNALRVWNV 138 >5FL8-q nrPDB Length = 515 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/100 (32%), Positives = 47/100 (47%), Gaps = 7/100 (7%) Query: 4 LLQDPFAVLKEHP-EKLTHTIENPLRT-ECLQFSP-CGDYLALGCANGALVIYDMDTFRP 60 LL P AV K P + + I T C F+P + G + I+D DT P Sbjct: 119 LLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTP 178 Query: 61 ICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 100 + + L H + ++WSPDG ++ T S D +I+LWD Sbjct: 179 M----HTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWD 214 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 36/134 (26%) Query: 8 PFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYD------MDTFRPI 61 P A + H + + H + FSP G Y+ + ++ ++D + TFR Sbjct: 394 PIARMTGHQKLVNH----------VAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFR-- 441 Query: 62 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP----- 116 HV + +AWS D RLL++ S+D ++K+WD+ +++ D P Sbjct: 442 --------GHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVR-----TRKLSVDLPGHKDE 488 Query: 117 IWGCQWLDAKRRLC 130 ++ W +R+C Sbjct: 489 VYTVDWSVDGKRVC 502 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 24/77 (31%), Positives = 43/77 (55%), Gaps = 10/77 (12%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-------D 83 C+ +SP G+ +A G + + ++D + + C+ G+ L H + ITS++W P Sbjct: 191 CVSWSPDGEVIATGSMDNTIRLWDPKSGQ--CL-GDALRGHSKWITSLSWEPIHLVKPGS 247 Query: 84 GRLLLTSSRDWSIKLWD 100 L +SS+D +IK+WD Sbjct: 248 KPRLASSSKDGTIKIWD 264 >3JB9-g nrPDB Length = 558 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 39/71 (54%), Gaps = 4/71 (5%) Query: 31 CLQFSPCGDYLAL-GCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLT 89 CL+F P +L L G + + I+++ R + H RPI +++S DGR L+ Sbjct: 271 CLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLL---RTFQGHARPIRDLSFSQDGRSFLS 327 Query: 90 SSRDWSIKLWD 100 +S D +IKLWD Sbjct: 328 TSFDKTIKLWD 338 >5BPW-A nrPDB Length = 843 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 8/170 (4%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPI--CVPGNMLGAHVRPITSIAWSPDGRLLLT 89 L +SP D +AL G ++++ + +F + P G + +T +AW PDG+LL Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTG---KEVTCLAWRPDGKLLAF 82 Query: 90 SSRDW-SIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 148 + D I L D+ KP + L ++P+ W++ V T F ++ Sbjct: 83 ALADTKKIVLCDVEKP-ESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPK 141 Query: 149 PVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKF 198 + S+ ++ S + ++ + NI+++G S G+++ Y + Sbjct: 142 LPTLPKNYSNTSKIFSEENSDEIIKLLGDVR-LNILVLGGSSGFIELYAY 190 >6HQA-B nrPDB Length = 722 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/83 (31%), Positives = 43/83 (51%), Gaps = 5/83 (6%) Query: 30 ECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLT 89 +C++F P YL G ++ ++D+ R CV + H I +A SPDGR L + Sbjct: 541 DCVEFHPNSTYLFTGSSDKTARMWDI--ARGECV--RVFMGHSGAINCLAVSPDGRWLAS 596 Query: 90 SSRDWSIKLWDLSKPSKPLKEIR 112 + D + LWD+S + +K +R Sbjct: 597 AGEDSVVCLWDIST-GRRIKAMR 618 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 42/193 (21%), Positives = 70/193 (36%), Gaps = 17/193 (8%) Query: 53 YDMDTFRPICVPGNM-LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI 111 Y+ + V G+ L H + + +SPD R L++ S D +++LW L + + Sbjct: 433 YNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYK 492 Query: 112 RFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYV 171 S +W + F Y S+D A L S L H Sbjct: 493 GHSSSVWDVK-------------FSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLND 539 Query: 172 LVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAI 231 + C + + G+S + + + EC+ S I L VS +G LA Sbjct: 540 VDCVEFHPNSTYLFTGSSDKTARMW---DIARGECVRVFMGHSGAINCLAVSPDGRWLAS 596 Query: 232 NCSDRTIRQYEIS 244 D + ++IS Sbjct: 597 AGEDSVVCLWDIS 609 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 57/245 (23%), Positives = 89/245 (36%), Gaps = 69/245 (28%) Query: 75 ITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLD-----AKRRL 129 +T + ++ D ++ + +D IKLW + PL+ + + P + Q D RRL Sbjct: 393 LTCLKFNDDSTMVASGFQDSFIKLWSID--GSPLRSLLKNDP-YNQQNNDGVAVKGSRRL 449 Query: 130 CVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTS 189 + Y +DFS PD+ Y++ C+ T Sbjct: 450 ----VGHSGAVYGVDFS-------------------PDNRYLISCSEDK---------TV 477 Query: 190 KGW-LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDE 248 + W LD Y C+ S K SS++ + S G A D+T R + Sbjct: 478 RLWSLDTYT--------CLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLW------- 522 Query: 249 NSAVELTLEHKYQDVINKLQWN---CILFSNNTAEYLVASTHGSSAHELYIWETTSGTLV 305 + +H Y I N C+ F N+ YL GSS +W+ G V Sbjct: 523 ------SCDHIYPLRIFAGHLNDVDCVEFHPNST-YLFT---GSSDKTARMWDIARGECV 572 Query: 306 RVLEG 310 RV G Sbjct: 573 RVFMG 577 >5WYJ-BE nrPDB Length = 939 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 45/88 (51%), Gaps = 5/88 (5%) Query: 30 ECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLT 89 + + S CG++ +G +NG++ IY+M + + H R +T I+ R +++ Sbjct: 464 KSVAMSQCGNFGFIGSSNGSITIYNMQS----GILRKKYKLHKRAVTGISLDGMNRKMVS 519 Query: 90 SSRDWSIKLWDLSKPSKPLKEIRFDSPI 117 D + +D +K S L +++ D+PI Sbjct: 520 CGLDGIVGFYDFNK-STLLGKLKLDAPI 546 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 4/71 (5%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 + + D AL + ++V+ D T R + L H IT+ +SP+GR ++++ Sbjct: 548 AMVYHRSSDLFALALDDLSIVVIDAVTQRVV----RQLWGHSNRITAFDFSPEGRWIVSA 603 Query: 91 SRDWSIKLWDL 101 S D +I+ WDL Sbjct: 604 SLDSTIRTWDL 614 >3C9C-A nrPDB Length = 432 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 6/89 (6%) Query: 18 KLTHTIE-NPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 K +HT++ + CL F+P ++ LA G A+ + ++D+ R + + + +H I Sbjct: 270 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHSFESHKDEI 326 Query: 76 TSIAWSPDGRLLLTSS-RDWSIKLWDLSK 103 + WSP +L SS D + +WDLSK Sbjct: 327 FQVQWSPHNETILASSGTDRRLHVWDLSK 355 Score = 27.7 bits (60), Expect = 9.6, Method: Compositional matrix adjust. Identities = 16/74 (21%), Positives = 41/74 (55%), Gaps = 4/74 (5%) Query: 270 NCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL-VRVLEGAEEELIDINWDFYSMSIV 328 NC+ F N +E+++A+ GS+ + +W+ + L + E ++E+ + W ++ +I+ Sbjct: 283 NCLSF-NPYSEFILAT--GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 339 Query: 329 SNGFESGNVYVWSV 342 ++ ++VW + Sbjct: 340 ASSGTDRRLHVWDL 353 >5MZH-A nrPDB Length = 452 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 47/212 (22%), Positives = 81/212 (38%), Gaps = 20/212 (9%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 CL F+P +A G + ++D++T + L H I S+ ++ G L++T Sbjct: 184 CLSFNPQSTIIATGSMDNTAKLWDVETGQERAT----LAGHRAEIVSLGFNTGGDLIVTG 239 Query: 91 SRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPV 150 S D +LWD +R + L R +T F + V+ S D Sbjct: 240 SFDHDSRLWD----------VRTGQCV---HVLSGHRGEVSSTQFNYAGTLVVSGSIDCT 286 Query: 151 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL 210 + L + LS H ++ ++ ++ G Y H+L C H+L Sbjct: 287 SRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLY--HTLTGV-CQHTL 343 Query: 211 KITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 I + + G RL SD+T R ++ Sbjct: 344 VGHEGEISKVAFNPQGTRLITASSDKTCRLWD 375 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 50/264 (18%), Positives = 97/264 (36%), Gaps = 31/264 (11%) Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 +L AH+ P+T+ A++ G +T S D + K+W+ + L+ Sbjct: 89 VLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFT-------------LEGH 135 Query: 127 RRLCVATIFEESDA-YVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 + + A F ++ S D L + + H +VC II Sbjct: 136 KNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIA 195 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISI 245 G+ + + + +L + I L + G+ + D R +++ Sbjct: 196 TGSMDNTAKLWDVETGQERA---TLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRT 252 Query: 246 DDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLV 305 V + H+ + ++ Q+ N A LV S GS +W+ SG + Sbjct: 253 ---GQCVHVLSGHRGE--VSSTQF-------NYAGTLVVS--GSIDCTSRLWDVRSGRCL 298 Query: 306 RVLEGAEEELIDINWDFYSMSIVS 329 V +G +E++D+ +D +VS Sbjct: 299 SVKQGHTDEVLDVAFDAAGTKMVS 322 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 30/136 (22%), Positives = 62/136 (45%), Gaps = 14/136 (10%) Query: 223 SQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYL 282 +++G+R DRT + + +E TLE +++V+ I F+N + + Sbjct: 103 NKSGDRFITGSYDRTCKVWNTFTGEE----VFTLE-GHKNVVYA-----IAFNNPYGDKI 152 Query: 283 VASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 V GS +W+ +G L L+G + E++ ++++ S +I++ G +W V Sbjct: 153 VT---GSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQS-TIIATGSMDNTAKLWDV 208 Query: 343 VIPPKWSALAPDFEEV 358 + + LA E+ Sbjct: 209 ETGQERATLAGHRAEI 224 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 17/68 (25%), Positives = 34/68 (50%), Gaps = 4/68 (5%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 + F+P G L ++ ++D DT + +L H I S A++ +G ++T S Sbjct: 353 VAFNPQGTRLITASSDKTCRLWDCDTGECL----QVLEGHTDEIFSCAFNYEGDFIITGS 408 Query: 92 RDWSIKLW 99 +D + ++W Sbjct: 409 KDNTCRIW 416 >5WYK-BB nrPDB Length = 943 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 27/91 (29%), Positives = 47/91 (51%), Gaps = 7/91 (7%) Query: 11 VLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA 70 VLK H + ++ L C++ SP YLA+ + + ++ +D+ + L Sbjct: 519 VLKLHHDTTLELTDDIL---CVRVSPDDRYLAISLLDNTVKVFFLDSMKFYL----SLYG 571 Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDL 101 H P+ SI S D ++++TSS D +IK+W L Sbjct: 572 HKLPVLSIDISFDSKMIITSSADKNIKIWGL 602 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/90 (31%), Positives = 43/90 (47%), Gaps = 6/90 (6%) Query: 12 LKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH 71 +K H K T E C +F P G + LG NG L ++D+ + + + AH Sbjct: 419 IKTH--KCIRTFECGYALTC-KFLPGGLLVILGTRNGELQLFDLASSSLL---DTIEDAH 472 Query: 72 VRPITSIAWSPDGRLLLTSSRDWSIKLWDL 101 I S+ + DG+ L+T S D ++K WD Sbjct: 473 DAAIWSLDLTSDGKRLVTGSADKTVKFWDF 502 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 36/63 (57%), Gaps = 4/63 (6%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKL 98 D LA+G A+G + ++D+ + + + + N H IT + + G L++ S+D +I + Sbjct: 92 DLLAVGYADGVIKVWDLMS-KTVLLNFN---GHKAAITLLQFDGTGTRLISGSKDSNIIV 147 Query: 99 WDL 101 WDL Sbjct: 148 WDL 150 Score = 32.3 bits (72), Expect = 0.41, Method: Compositional matrix adjust. Identities = 33/126 (26%), Positives = 52/126 (41%), Gaps = 9/126 (7%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 LQF G L G + ++++D+ V L +H IT W L+++S Sbjct: 127 LQFDGTGTRLISGSKDSNIIVWDLVG----EVGLYKLRSHKDSITGF-WCQGEDWLISTS 181 Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE-ESDAYVIDFSNDPV 150 +D IKLWDL I WG L K L + T + + + +D ND + Sbjct: 182 KDGMIKLWDLKTHQCIETHIAHTGECWG---LAVKDDLLITTGTDSQVKIWKLDIENDKM 238 Query: 151 ASLLSK 156 L++ Sbjct: 239 GGKLTE 244 Score = 31.2 bits (69), Expect = 0.99, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 32/59 (54%), Gaps = 5/59 (8%) Query: 43 LGCANGALVIY-DMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 100 C+ A+V Y D + F I L AH + ++A + DG +++SS D SI++W+ Sbjct: 631 FSCSKDAVVKYWDGEKFECI----QKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWE 685 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 9/117 (7%) Query: 20 THTIE-NPLRTECLQFSPCGDYLALGCA-NGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 THTIE RT+ D L A NG+L I+++ T + C+ G + + Sbjct: 382 THTIELQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKTHK--CIRTFECGYAL----T 435 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPS-KPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + P G L++ +R+ ++L+DL+ S E D+ IW +RL + Sbjct: 436 CKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGS 492 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 11/87 (12%) Query: 169 GYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHS---LYQTECIHSLKITSSNIKHLIVSQN 225 GY L C ++I+GT G L + S L E H I S L ++ + Sbjct: 431 GYALTCKF-LPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWS-----LDLTSD 484 Query: 226 GERLAINCSDRTIRQYEISIDDENSAV 252 G+RL +D+T++ ++ + ENS V Sbjct: 485 GKRLVTGSADKTVKFWDFKV--ENSLV 509 >3ACP-A nrPDB Length = 417 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 33/65 (50%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRL 129 AHV IT + + P G L++SS+D +K+W + S P I + + +D R + Sbjct: 134 AHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNV 193 Query: 130 CVATI 134 A++ Sbjct: 194 LSASL 198 >6QX9-5O nrPDB Length = 357 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 61/312 (19%), Positives = 132/312 (42%), Gaps = 36/312 (11%) Query: 8 PFAVLKEHPEKLTHTIENPL--------RTECLQFSPCGDYLALGCANGALVIYDMDTFR 59 P A+L+ P + + +++ P+ C +F P G LA + ++++++ Sbjct: 41 PGALLQAGPPRCS-SLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV---Y 96 Query: 60 PICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWG 119 C L H + + ++ DG +L ++S D ++ +WD S+ + +K ++ + Sbjct: 97 GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD-SETGERVKRLKGHTSFVN 155 Query: 120 CQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTK 179 + A+R V S+D L + + + + VL T + Sbjct: 156 SCY-PARR----------GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDT 204 Query: 180 HPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIR 239 II S G + K L Q + ++++ + ++ L +S G L N D T+R Sbjct: 205 SDQII----SGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVR 260 Query: 240 QYEIS-IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 298 +++ + V++ +Q ++ + N + S + +A+ GS+ +Y+W+ Sbjct: 261 VWDVRPFAPKERCVKI-----FQGNVHNFEKNLLRCSWSPDGSKIAA--GSADRFVYVWD 313 Query: 299 TTSGTLVRVLEG 310 TTS ++ L G Sbjct: 314 TTSRRILYKLPG 325 >1NR0-A nrPDB Length = 611 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/97 (25%), Positives = 49/97 (50%), Gaps = 4/97 (4%) Query: 10 AVLKEHPEKLTHTI-ENPLRTECLQFSPCGDYLALGCANGALVIYD-MDTFRPICVPGNM 67 A+ + P K T E+ ++++P G A +G +V+Y+ +D + + Sbjct: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS 232 Query: 68 LG--AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 L AH + + WSPDG + ++S D +IK+W+++ Sbjct: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 3/85 (3%) Query: 22 TIENPLRTECLQFSPCGDYLALGCANGALVIYDM-DTFRPICVPGNMLGAHVRPITSIAW 80 TI +P + FS G +L + ++ Y + + F N H + ++W Sbjct: 487 TIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFE--LAHTNSWTFHTAKVACVSW 544 Query: 81 SPDGRLLLTSSRDWSIKLWDLSKPS 105 SPD L T S D S+ +W+++KPS Sbjct: 545 SPDNVRLATGSLDNSVIVWNMNKPS 569 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 20/33 (60%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 H + IT+++ S DG+ L ++ + I WD+S Sbjct: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 >5Y1U-A nrPDB Length = 456 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 47/89 (52%), Gaps = 6/89 (6%) Query: 18 KLTHTIE-NPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 K +H+++ + CL F+P ++ LA G A+ + ++D+ R + + + +H I Sbjct: 295 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHSFESHKDEI 351 Query: 76 TSIAWSPDGRLLLTSS-RDWSIKLWDLSK 103 + WSP +L SS D + +WDLSK Sbjct: 352 FQVQWSPHNETILASSGTDRRLNVWDLSK 380 Score = 28.5 bits (62), Expect = 5.9, Method: Compositional matrix adjust. Identities = 17/49 (34%), Positives = 26/49 (53%), Gaps = 1/49 (2%) Query: 62 CVPGNMLGAHVRPITSIAWSPD-GRLLLTSSRDWSIKLWDLSKPSKPLK 109 C P L H + ++W+P+ LL++S D +I LWD+S K K Sbjct: 198 CNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 246 >3CFV-B nrPDB Length = 414 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 24/75 (32%), Positives = 40/75 (53%), Gaps = 5/75 (6%) Query: 31 CLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLT 89 CL F+P ++ LA G A+ + ++D+ R + + + +H I + WSP +L Sbjct: 280 CLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHTFESHKDEIFQVHWSPHNETILA 336 Query: 90 SS-RDWSIKLWDLSK 103 SS D + +WDLSK Sbjct: 337 SSGTDRRLNVWDLSK 351 >5NZU-C nrPDB Length = 905 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/173 (23%), Positives = 66/173 (38%), Gaps = 39/173 (22%) Query: 26 PLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGR 85 P+R +F +++ G + + +++ +T + +M AH I IA P Sbjct: 59 PVR--AAKFVARKNWVVTGADDMQIRVFNYNTLERV----HMFEAHSDYIRCIAVHPTQP 112 Query: 86 LLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDF 145 +LTSS D IKLWD K W C + +FE YV+ Sbjct: 113 FILTSSDDMLIKLWDWDKK-------------WSC-----------SQVFEGHTHYVMQI 148 Query: 146 SNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKG--WLDFY 196 +P D Q +S + V + + PN + G KG +D+Y Sbjct: 149 VINP-------KDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYY 194 >5GAN-H nrPDB Length = 465 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 35/73 (47%), Gaps = 4/73 (5%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 L F G + G + +++D+ + + L H +PI ++AWSP+G + T Sbjct: 312 SLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMT----LAGHSKPIYTVAWSPNGYQVATG 367 Query: 91 SRDWSIKLWDLSK 103 D I +WD+ K Sbjct: 368 GGDGIINVWDIRK 380 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 85/213 (39%), Gaps = 32/213 (15%) Query: 28 RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 87 R +++ P G ++ + ++D T + + + H + + S+++ DG L+ Sbjct: 267 RISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQE----GHDKGVFSLSFQCDGSLV 322 Query: 88 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSN 147 + D LWD+ SK + PI+ W + VAT + V D Sbjct: 323 CSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAW--SPNGYQVATGGGDGIINVWD--- 377 Query: 148 DPVASLLSKSDEKQLSSTPDHGYVLVCTVHTK-----------HPNIIIVGTSKGWLDFY 196 + K DE QL+ H ++ +K + N+I V +S WL Sbjct: 378 ------IRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWL--- 428 Query: 197 KFHSLY-QTECIHSLKITSSNIKHLIVSQNGER 228 K SL T+ I SL I SN H +VS +R Sbjct: 429 KMGSLAGHTDKIISLDI--SNNSHFLVSGGWDR 459 Score = 31.6 bits (70), Expect = 0.76, Method: Compositional matrix adjust. Identities = 15/54 (27%), Positives = 31/54 (57%), Gaps = 1/54 (1%) Query: 65 GNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIW 118 G+++G H R I+ + + P G+ + ++S D + +LWD S + L + D ++ Sbjct: 259 GDLVG-HERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVF 311 >6QX9-4B nrPDB Length = 522 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 59/263 (22%), Positives = 102/263 (38%), Gaps = 47/263 (17%) Query: 11 VLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA 70 L+ H + + +P T + P LA A+G++ ++ +D+ P+ ++ G Sbjct: 268 TLRGHNTNVGAIVFHPKST--VSLDPKDVNLASCAADGSVKLWSLDSDEPVA---DIEGH 322 Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKE---------IRF--DSPIWG 119 VR + + W P GR L T+ D S +LWDL + L + I F D + G Sbjct: 323 TVR-VARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAG 381 Query: 120 CQWLDAKRRL-------CVATI-----------FEESDAYVIDFSNDPVASLLSKSDEKQ 161 LDA R+ C+ + F + ++ S D + + Sbjct: 382 TGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441 Query: 162 LSSTPDH-GYVLVCTVHTKHPNIIIVG----TSKGWLDFYKFHSLYQTECIHSLKITSSN 216 + + P H V H N ++ G T+K W + S +T H K+ Sbjct: 442 VYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT--HPGWSPLKTLAGHEGKVMG-- 497 Query: 217 IKHLIVSQNGERLAINCSDRTIR 239 L +S +G+ +A DRT + Sbjct: 498 ---LDISSDGQLIATCSYDRTFK 517 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 32/69 (46%), Gaps = 5/69 (7%) Query: 32 LQFSPC-GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 ++F P G++L G + I+ + P+ L H + + S DG+L+ T Sbjct: 455 VKFEPIHGNFLLTGAYDNTAKIWTHPGWSPL----KTLAGHEGKVMGLDISSDGQLIATC 510 Query: 91 SRDWSIKLW 99 S D + KLW Sbjct: 511 SYDRTFKLW 519 >5Y88-O nrPDB Length = 451 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 46/216 (21%), Positives = 85/216 (39%), Gaps = 25/216 (11%) Query: 30 ECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLT 89 + P D +A + + ++DM T P+ L H PI + +P +++ Sbjct: 228 RTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVIT----LVGHKGPINQVQCTPVDPQVVS 283 Query: 90 SSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDP 149 SS D +++LWD+ K +K L +R AT + V D Sbjct: 284 SSTDATVRLWDVV-AGKTMKV------------LTHHKRSVRATALHPKEFSVASACTDD 330 Query: 150 VASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY------KFHSLYQ 203 + S ++ L++ ++ T+ +++ G G L FY K+ SL Sbjct: 331 IRS-WGLAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLAT 389 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIR 239 E + SL+ S + + G RL +D++I+ Sbjct: 390 REMVGSLEGERSVLCSTF-DKTGLRLITGEADKSIK 424 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 38/90 (42%), Gaps = 6/90 (6%) Query: 16 PEKLTHTIENPLR-TECLQFSPC-GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 P KL+ I L C+ P ++ G + + ++D+ T + L HV Sbjct: 128 PWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKL----KTTLAGHVM 183 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSK 103 + +A S L + S D ++K WDL K Sbjct: 184 TVRDVAVSDRHPYLFSVSEDKTVKCWDLEK 213 >5BPT-A nrPDB Length = 741 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 51/106 (48%), Gaps = 5/106 (4%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPI-CVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 L +SP D +AL G ++++ + + + +P N + +T +AW PDG++L Sbjct: 19 LAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTG--KEVTCLAWRPDGKILAFG 76 Query: 91 SRDW-SIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIF 135 D + L D+ KP + L ++PI QW++ V T F Sbjct: 77 LADTKKVILCDVEKP-ESLHSFSLETPISCMQWMEVNVENSVLTSF 121 >4XYI-A nrPDB Length = 430 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 5/72 (6%) Query: 34 FSPCGDYL-ALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-DGRLLLTSS 91 F+P DYL A A+ + ++D+ R + + L H + ++ WSP D +L+TSS Sbjct: 289 FNPFNDYLLATASADHTVALWDL---RRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSS 345 Query: 92 RDWSIKLWDLSK 103 D + +WDLSK Sbjct: 346 TDRRVCVWDLSK 357 >6N9G-C nrPDB Length = 353 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 22/78 (28%), Positives = 39/78 (50%), Gaps = 8/78 (10%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGN---MLGAHVRPITSIAWSPDGRLLL 88 +++ P GD A G + +YD+ R + + + GA +S+ +S GRLL Sbjct: 245 VRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGA-----SSVDFSLSGRLLF 299 Query: 89 TSSRDWSIKLWDLSKPSK 106 D++I +WD+ K S+ Sbjct: 300 AGYNDYTINVWDVLKGSR 317 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 48/288 (16%), Positives = 100/288 (34%), Gaps = 58/288 (20%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW----- 122 L H + + W D R +++SS+D + +WD +K + + C + Sbjct: 59 LKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGC 118 Query: 123 -----------------------LDAKRRLCV-------ATIFEESDAYVIDFSNDPVAS 152 + AK++ A F SD ++ S D + Sbjct: 119 AIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCA 178 Query: 153 LLSKSDEKQLSSTPDHGYVLVCT--VHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL 210 L + L S HG ++C ++ N + G + S +C+ + Sbjct: 179 LWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS---GQCVQAF 235 Query: 211 KITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWN 270 + S++ + +G+ A D T R Y++ D E + Sbjct: 236 ETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADRE---------------VAIYSKE 280 Query: 271 CILFSNNTAEYLVAST---HGSSAHELYIWETTSGTLVRVLEGAEEEL 315 I+F ++ ++ ++ G + + + +W+ G+ V +L G E + Sbjct: 281 SIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRV 328 >6EOJ-D nrPDB Length = 470 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 45/79 (56%), Gaps = 6/79 (7%) Query: 32 LQFSPCGDYL-ALGCANGALVIYDM--DTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 L++ P + + L C +G+L +D+ + PI + AH + ITS++++P G + Sbjct: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILT---IPYAHDKCITSLSYNPVGHIFA 366 Query: 89 TSSRDWSIKLWDLSKPSKP 107 T+++D +I+ W ++P P Sbjct: 367 TAAKDRTIRFWTRARPIDP 385 >4BH6-A nrPDB Length = 308 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 100/246 (40%), Gaps = 43/246 (17%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 L + G +LA+G ANG + IYD+ + C+ L H+ + ++W + +L + S Sbjct: 68 LSWIGAGSHLAVGQANGLVEIYDV--MKRKCI--RTLSGHIDRVACLSW--NNHVLTSGS 121 Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSP-IWGCQWLDAKRRLCVAT----------------- 133 RD I D+ P + I + + G +W A +L Sbjct: 122 RDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPIL 181 Query: 134 IFEESDAYVIDFSNDP----VASLLSKSDEKQLS----------STPDHGYVLVCTVHTK 179 F+E A V + P V + + +++L S D G + V +K Sbjct: 182 TFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSK 241 Query: 180 HPNIIIV--GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRT 237 + N ++ G SK L + +S+ + I LK S + HL +S +G + D T Sbjct: 242 NTNELVTSHGYSKYNLTLWDCNSM---DPIAILKGHSFRVLHLTLSNDGTTVVSGAGDET 298 Query: 238 IRQYEI 243 +R +++ Sbjct: 299 LRYWKL 304 >5A31-R nrPDB Length = 386 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 100/246 (40%), Gaps = 43/246 (17%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 L + G +LA+G ANG + IYD+ + C+ L H+ + ++W + +L + S Sbjct: 137 LSWIGAGSHLAVGQANGLVEIYDV--MKRKCI--RTLSGHIDRVACLSW--NNHVLTSGS 190 Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSP-IWGCQWLDAKRRLCVAT----------------- 133 RD I D+ P + I + + G +W A +L Sbjct: 191 RDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPIL 250 Query: 134 IFEESDAYVIDFSNDP----VASLLSKSDEKQLS----------STPDHGYVLVCTVHTK 179 F+E A V + P V + + +++L S D G + V +K Sbjct: 251 TFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSK 310 Query: 180 HPNIIIV--GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRT 237 + N ++ G SK L + +S+ + I LK S + HL +S +G + D T Sbjct: 311 NTNELVTSHGYSKYNLTLWDCNSM---DPIAILKGHSFRVLHLTLSNDGTTVVSGAGDET 367 Query: 238 IRQYEI 243 +R +++ Sbjct: 368 LRYWKL 373 >5WLC-LS nrPDB Length = 594 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 32/102 (31%), Positives = 48/102 (47%), Gaps = 23/102 (22%) Query: 8 PFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNM 67 P A L ++LT TI N LQFSP G L + A+ A+ D R + +P Sbjct: 507 PVAAL----DQLTTTISN------LQFSPDGQILCM--ASRAV----KDALRLVHLPSCS 550 Query: 68 L-------GAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 + G + +TS+A+SP G LL + ++LW L+ Sbjct: 551 VFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 >6Q8F-A nrPDB Length = 514 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 44/211 (20%), Positives = 88/211 (41%), Gaps = 23/211 (10%) Query: 13 KEHPEKLTHTIENPLRT--ECLQFSPCGDYLALGCANGALVIYDMDTFR-----PICVPG 65 ++ P +L+ I+ ++ EC +FSP G YL G +G + +++ T + Sbjct: 200 EKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 259 Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 N + + + +S D +L T ++D IK+W + + + L+ RF+ + Sbjct: 260 NFMMMD-DAVLCMCFSRDTEMLATGAQDGKIKVWKI-QSGQCLR--RFERA-------HS 308 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 K C++ F + + ++ S D + K L H + T+ + II Sbjct: 309 KGVTCLS--FSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYII 366 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSN 216 +S G + + + TEC ++ K S Sbjct: 367 SASSDGTVKIWNMKT---TECSNTFKSLGST 394 >5K19-A nrPDB Length = 569 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 19/70 (27%), Positives = 36/70 (51%), Gaps = 4/70 (5%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 FSP G +LA +G L +++ D+ + + G M ++ + + WSPDG+ ++T Sbjct: 226 FAFSPDGKFLACVSQDGFLRVFNFDS---VELHGTM-KSYFGGLLCVCWSPDGKYIVTGG 281 Query: 92 RDWSIKLWDL 101 D + +W Sbjct: 282 EDDLVTVWSF 291 >4XFV-A nrPDB Length = 792 Score = 36.6 bits (83), Expect = 0.021, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 91/238 (38%), Gaps = 38/238 (15%) Query: 31 CLQFSPCGDYLALGC-----ANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGR 85 CL SP +A C N + I+ + + I L H IT + +S DG+ Sbjct: 567 CLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEI---KPALPFHSLTITRLKFSKDGK 623 Query: 86 LLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP------IWGCQWLDAKRRLCVATIFEESD 139 LL+ RD LW+ + E+RF + IW W + T + Sbjct: 624 FLLSVCRDRKWALWERNMEDNTF-ELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKT 682 Query: 140 AYVIDFSNDPVASLLSKSDEKQLSSTPDH-GYVLVCTVH---TKHPNIIIVGTSKGWLDF 195 V +P +D+ L ++ H V ++H + +I VG G + Sbjct: 683 VKVWRHQKEP-------ADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYL 735 Query: 196 YKFHSLYQTECIHSL--------KITSSNIKHLIVSQNGER-LAINCSDRTIRQYEIS 244 Y + +L + E I L KIT HL +NG+ L + SD + R Y ++ Sbjct: 736 YSY-TLGKFELITQLNEDITPADKITRLRWSHL--KRNGKLFLGVGSSDLSTRIYSLA 790 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 21/39 (53%) Query: 61 ICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 IC + + +T IAWSP G LL +S D + +L+ Sbjct: 378 ICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 416 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 41/200 (20%), Positives = 76/200 (38%), Gaps = 44/200 (22%) Query: 162 LSSTPDHGYVL-VCTVHTKHPNIIIVGTSKGWLDF---YKFHSLYQTECIHSLKITSSNI 217 L +PD + C + +I + +++ WL+ FHSL I Sbjct: 568 LDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSL--------------TI 613 Query: 218 KHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNN 277 L S++G+ L C DR +E +++D + E + +I W + F N Sbjct: 614 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN- 672 Query: 278 TAEYLVAST--------HGSSAHELYIWE-----TTSGTLVRVLEGAEEELIDINWDFYS 324 ++ AS H + Y+ E T + T + + + E I Sbjct: 673 --VFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKI-------- 722 Query: 325 MSIVSNGFESGNVYVWSVVI 344 ++S G E+G +Y++S + Sbjct: 723 --LISVGLENGEIYLYSYTL 740 >3DM0-A nrPDB Length = 694 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 23/92 (25%), Positives = 46/92 (50%), Gaps = 10/92 (10%) Query: 9 FAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNML 68 + V + +H +E+ + + QF+ G + +G L ++D+ V Sbjct: 419 YGVAQRRLTGHSHFVEDVVLSSDGQFALSGSW------DGELRLWDL----AAGVSTRRF 468 Query: 69 GAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 100 H + + S+A+S D R ++++SRD +IKLW+ Sbjct: 469 VGHTKDVLSVAFSLDNRQIVSASRDRTIKLWN 500 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 1/72 (1%) Query: 62 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 C + L H ++++A SPDG L + +D + LWDL++ K L + +S I Sbjct: 551 CKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAE-GKKLYSLEANSVIHALC 609 Query: 122 WLDAKRRLCVAT 133 + + LC AT Sbjct: 610 FSPNRYWLCAAT 621 >5LTD-A nrPDB Length = 525 Score = 35.8 bits (81), Expect = 0.032, Method: Compositional matrix adjust. Identities = 39/141 (27%), Positives = 58/141 (41%), Gaps = 38/141 (26%) Query: 3 ILLQDPFAVLKEHPEKLTHTIENPLRTECL-QFSPCG--DYLALGCA------------- 46 +LL++ + + +L HTIE P L SP +YLA Sbjct: 133 VLLEETIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTL 192 Query: 47 --------NGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS------R 92 NG ++I+D T +P V + AH + +IA S DG LL T+S R Sbjct: 193 HSNPQTVRNGDVIIFDAKTLQPTSV----IEAHRTSLAAIALSKDGLLLATASDKGTIIR 248 Query: 93 DWS----IKLWDLSKPSKPLK 109 +S IKL+ + + P K Sbjct: 249 VFSVATGIKLYQFRRGTYPTK 269 >5N4A-A nrPDB Length = 771 Score = 35.8 bits (81), Expect = 0.036, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 40/95 (42%), Gaps = 6/95 (6%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKL 98 D A+ C +G++ I + G H S+ WS DG L T+ D S+K+ Sbjct: 76 DVFAVACTDGSVKILSRTGRVEKSIEG-----HKGACISLRWSYDGTALATAGEDGSVKI 130 Query: 99 WDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 W + + + DSP++ W +LC T Sbjct: 131 WSRNGMLRSTLA-QADSPVYSIVWAYDCDQLCYCT 164 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 24/57 (42%), Gaps = 1/57 (1%) Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW 122 N AH + + WSP L++T D K+WD S + FD P+ W Sbjct: 180 NAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWD-SFGRLLFQSGLFDYPVTSVAW 235 >5OQL-J nrPDB Length = 912 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 22/62 (35%), Positives = 33/62 (53%), Gaps = 3/62 (4%) Query: 41 LALGCANGALVIYDM--DTFRPICV-PGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK 97 LA G +G + I+D+ T P+ P AH + IA+SP+ LL+ SRD ++ Sbjct: 198 LAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMT 257 Query: 98 LW 99 LW Sbjct: 258 LW 259 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 25/34 (73%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSK 103 AH + I ++ SP+G+L ++S+D ++K+WD+ K Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEK 575 Score = 32.7 bits (73), Expect = 0.35, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 33/77 (42%), Gaps = 8/77 (10%) Query: 31 CLQFSPCGDYLALGCANGALVIY------DMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 L +P G +L + + + IY D D+ P V H P+ +A Sbjct: 66 TLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLV--RTTKPHATPVVVLAVDRTS 123 Query: 85 RLLLTSSRDWSIKLWDL 101 LL T + D +IK+WD+ Sbjct: 124 TLLATGAADGAIKIWDI 140 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 32/120 (26%), Positives = 52/120 (43%), Gaps = 27/120 (22%) Query: 6 QDPFAVLKEHPEKLTH--TIENPLR-------TECLQFSPCGDYLALGCANGALVIYDMD 56 QD F ++ P +L + + LR L SP G A + + I+D++ Sbjct: 515 QDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVE 574 Query: 57 TFRPICVPGNMLGAHVRPITSIAWSP-------------DGR-LLLTSSRDWSIKLWDLS 102 V G +L H R + ++ ++P GR ++LT S D +IKLW+LS Sbjct: 575 KLE---VQG-ILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLS 630 >4A11-B nrPDB Length = 408 Score = 35.4 bits (80), Expect = 0.046, Method: Compositional matrix adjust. Identities = 45/229 (19%), Positives = 94/229 (41%), Gaps = 16/229 (6%) Query: 38 GDYLALGCANGALVIYDMD--------TFRPICVPG-NMLGAHVRPITSIAWSP-DGRLL 87 G Y+ G ++G +V+YD++ T + +C G + H + ++ W P D + Sbjct: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMF 115 Query: 88 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLC-VATIFEESDAYVIDFS 146 +SS D ++K+WD + + F+ ++ + C VA + D Sbjct: 116 TSSSFDKTLKVWD-TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLK 174 Query: 147 NDPVASLLSKSDEKQL--SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT 204 + + +L ++ L S +P + Y+L + V + G L H+ ++ Sbjct: 175 SGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKS 234 Query: 205 ECIHSLKIT-SSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAV 252 + + S + + L + +G L +D +R + S + EN+ V Sbjct: 235 QAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN-SSNGENTLV 282 >6G51-g nrPDB Length = 317 Score = 35.4 bits (80), Expect = 0.047, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 33/63 (52%), Gaps = 4/63 (6%) Query: 38 GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK 97 G + G +G L ++D+ T H + + S+A+S D R +++ SRD +IK Sbjct: 75 GQFALSGSWDGTLRLWDLTTGTTT----RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130 Query: 98 LWD 100 LW+ Sbjct: 131 LWN 133 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 23/40 (57%) Query: 63 VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 +P L H ++ + S DG+ L+ S D +++LWDL+ Sbjct: 54 IPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT 93 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 64/142 (45%), Gaps = 12/142 (8%) Query: 30 ECLQFSP-CGDYLALGCANGALV-IYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 87 C++FSP + + + C LV ++++ + + N +G H + ++ SPDG L Sbjct: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK---LKTNHIG-HTGYLNTVTVSPDGSLC 207 Query: 88 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT-----IFEESDAYV 142 + +D LWDL++ K L + I + + LC AT I++ + Sbjct: 208 ASGGKDGQAMLWDLNE-GKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKII 266 Query: 143 IDFSNDPVASLLSKSDEKQLSS 164 +D V S SK++ Q +S Sbjct: 267 VDELKQEVISTSSKAEPPQCTS 288 >1VYH-C nrPDB Length = 410 Score = 35.4 bits (80), Expect = 0.047, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 37/70 (52%), Gaps = 4/70 (5%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 + F G LA A+ + ++D F I + H ++S++ P+G ++++S Sbjct: 156 ISFDHSGKLLASCSADMTIKLWDFQGFECI----RTMHGHDHNVSSVSIMPNGDHIVSAS 211 Query: 92 RDWSIKLWDL 101 RD +IK+W++ Sbjct: 212 RDKTIKMWEV 221 Score = 31.6 bits (70), Expect = 0.71, Method: Compositional matrix adjust. Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 11/99 (11%) Query: 6 QDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPG 65 +DP + PEK + T + F P + + + ++D +T G Sbjct: 89 RDPKEWIPRPPEKYALSGHRSPVTRVI-FHPVFSVMVSASEDATIKVWDYET-------G 140 Query: 66 NM---LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDL 101 + L H + I++ G+LL + S D +IKLWD Sbjct: 141 DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDF 179 Score = 27.7 bits (60), Expect = 9.0, Method: Compositional matrix adjust. Identities = 38/176 (21%), Positives = 65/176 (36%), Gaps = 58/176 (32%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKR 127 L H P+T + + P +++++S D +IK+WD D +R Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG-------------------DFER 144 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVG 187 T+ +D+ V D S D LL+ C+ Sbjct: 145 -----TLKGHTDS-VQDISFDHSGKLLAS-----------------CSADM--------- 172 Query: 188 TSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 T K W DF F ECI ++ N+ + + NG+ + D+TI+ +E+ Sbjct: 173 TIKLW-DFQGF------ECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEV 221 >5WLC-LH nrPDB Length = 896 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 9/114 (7%) Query: 10 AVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLG 69 ++L + L++ N + G LA+G A+G + I + + +L Sbjct: 243 SILSSQTQSLSY---NTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQI-----RLLK 294 Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWL 123 H+ + S+++S DG LL+ + + LW L S+ R + I CQ L Sbjct: 295 WHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLP-RLNGIIIDCQVL 347 >4V7E-Bg nrPDB Length = 380 Score = 35.0 bits (79), Expect = 0.061, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 1/83 (1%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 E P+ T + FS G L G +NG ++D + G + +H I+ + S D Sbjct: 297 ELPIVTS-VAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSD 355 Query: 84 GRLLLTSSRDWSIKLWDLSKPSK 106 G L T S D ++K+W S K Sbjct: 356 GSALCTGSWDKNLKIWAFSGHRK 378 >4E5Z-B nrPDB Length = 436 Score = 35.0 bits (79), Expect = 0.062, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 10/100 (10%) Query: 12 LKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH 71 L+ H +K+TH NP C +LA + + I+D+ R L H Sbjct: 246 LRMHKKKVTHVALNPC---------CDWFLATASVDQTVKIWDLRQVRGKASFLYSL-PH 295 Query: 72 VRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI 111 P+ + +SPDG LLT+ + I+++ S+ PL I Sbjct: 296 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 335 >6J6H-n nrPDB Length = 455 Score = 35.0 bits (79), Expect = 0.068, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 19/98 (19%) Query: 8 PFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALV-----IYDMDTFRPIC 62 P V++ +P +P T L+F P +L L N + +D + R Sbjct: 151 PKKVIRNYPG-------HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRD-- 201 Query: 63 VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 100 H +PI ++ ++ D + L+SS D S+K+WD Sbjct: 202 -----FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 12/41 (29%), Positives = 28/41 (68%), Gaps = 1/41 (2%) Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI 111 H+ I ++ + PDG ++SS D ++++W+ ++ + P+K+I Sbjct: 292 HLSSILALKYFPDGSKFISSSEDKTVRIWE-NQINVPIKQI 331 Score = 28.5 bits (62), Expect = 5.1, Method: Compositional matrix adjust. Identities = 45/202 (22%), Positives = 79/202 (39%), Gaps = 37/202 (18%) Query: 70 AHVRPITSIAWSPD-GRLLLTSSRDWSIKLW----------DLSKPSKPLKEIRFDSPIW 118 H T++ + P G L+L+ D +IK+W D +KP+K +RF Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE--- 216 Query: 119 GCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHT 178 CQ +++ F+ S + D V + L L+STP V + Sbjct: 217 DCQSF-------LSSSFDRS-VKIWDTETGKVKTRL------HLNSTP-------ADVES 255 Query: 179 K--HPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDR 236 + +P+ IVG S + Y + + S+I L +G + + D+ Sbjct: 256 RPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDK 315 Query: 237 TIRQYEISIDDENSAVELTLEH 258 T+R +E I+ + T +H Sbjct: 316 TVRIWENQINVPIKQISDTAQH 337 >5OQL-X nrPDB Length = 630 Score = 35.0 bits (79), Expect = 0.070, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 34/70 (48%), Gaps = 4/70 (5%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 ++ S G ++ G A+ LV+Y+ +PI H +T +A+ L + S Sbjct: 252 VKASQDGKFVVTGGADKRLVVYNAADLKPI----KAFTQHRDAVTGLAFRRGTNQLYSCS 307 Query: 92 RDWSIKLWDL 101 +D ++K+W L Sbjct: 308 KDRTVKVWSL 317 >4V6W-Ag nrPDB Length = 318 Score = 34.7 bits (78), Expect = 0.091, Method: Compositional matrix adjust. Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 4/63 (6%) Query: 38 GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK 97 G+Y G + L ++D+ + H + + S+A+S D R +++ SRD +IK Sbjct: 76 GNYALSGSWDQTLRLWDLAAGKTT----RRFEGHTKDVLSVAFSADNRQIVSGSRDKTIK 131 Query: 98 LWD 100 LW+ Sbjct: 132 LWN 134 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 110/292 (37%), Gaps = 43/292 (14%) Query: 64 PGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWL 123 P L H I+ + S DG L+ S D +++LWDL+ RF+ Sbjct: 56 PQKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTR---RFEG-------- 104 Query: 124 DAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDH--GYVLVCTVHTKHP 181 K L VA F + ++ S D L + E + + D +V H Sbjct: 105 HTKDVLSVA--FSADNRQIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHS 162 Query: 182 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 N IIV S GW K +L + ++ + + + VS +G D + Sbjct: 163 NPIIV--SCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLW 220 Query: 242 EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS 301 +++ D +N TLEH D+IN L FS N Y + +G S + IW+ Sbjct: 221 DLN-DGKN---LYTLEH--NDIINAL-----CFSPN--RYWLCVAYGPS---IKIWDLAC 264 Query: 302 GTLVRVL---------EGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVI 344 V L + + + + + W ++ + G+ + VW V + Sbjct: 265 KKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFA-GYSDNTIRVWQVSV 315 >2AQ5-A nrPDB Length = 402 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 15/101 (14%) Query: 5 LQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVP 64 L++P L+ H +++ +P L L+ GC N ++++D+ T + Sbjct: 120 LREPVITLEGHTKRVGIVAWHPTAQNVL--------LSAGCDN-VILVWDVGTGAAVLT- 169 Query: 65 GNMLGAHVRP--ITSIAWSPDGRLLLTSSRDWSIKLWDLSK 103 LG V P I S+ WS DG L+ TS RD +++ + K Sbjct: 170 ---LGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRK 207 >5WLC-LJ nrPDB Length = 513 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 2/78 (2%) Query: 34 FSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRD 93 F G L G A G + +YD R I + N H +T + D ++L T+S D Sbjct: 89 FRSDGKLLCAGDATGLVSVYDSYNPRTILLSINA-STHPTHVTKF-HTQDNKILATASDD 146 Query: 94 WSIKLWDLSKPSKPLKEI 111 +LWD+S +P E+ Sbjct: 147 RVTRLWDISNAYEPQLEL 164 >5WBU-D nrPDB Length = 328 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 27/99 (27%), Positives = 40/99 (40%), Gaps = 21/99 (21%) Query: 63 VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLK-EIRFDSP----- 116 +P + AH R +SPD LL T S D + K+W S S + I+ +P Sbjct: 213 IPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSR 272 Query: 117 --IWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL 153 +WGC F Y++ S+D +A L Sbjct: 273 GWMWGCA-------------FSGDSQYIVTASSDNLARL 298 Score = 28.9 bits (63), Expect = 4.8, Method: Compositional matrix adjust. Identities = 13/46 (28%), Positives = 25/46 (54%), Gaps = 1/46 (2%) Query: 73 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI-RFDSPI 117 + I S+ + DGR + T D + ++WDL + + I + ++PI Sbjct: 88 KNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 133 >1PI6-A nrPDB Length = 615 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 26/113 (23%), Positives = 51/113 (45%), Gaps = 15/113 (13%) Query: 11 VLKEHPEKLTHTIENPLRTE--CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNML 68 V K +++ ++ PLR + + SP Y+A G G +++YD+ + V + Sbjct: 471 VFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE---VKTSRW 527 Query: 69 GAHVRPITSIAWSPDGR----------LLLTSSRDWSIKLWDLSKPSKPLKEI 111 I +I+W P + L+ T S D +I ++ + +P K +K + Sbjct: 528 AFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKAL 580 >5WLC-LW nrPDB Length = 554 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 35/73 (47%), Gaps = 4/73 (5%) Query: 29 TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 T + +P + LG +NG + ++ P+ +L A P+ SIA G + Sbjct: 235 TMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLV---KLLSARG-PVNSIAIDRSGYYMA 290 Query: 89 TSSRDWSIKLWDL 101 T+ D S+K+WD+ Sbjct: 291 TTGADRSMKIWDI 303 >5G04-R nrPDB Length = 499 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 9/135 (6%) Query: 207 IHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINK 266 + +L S + L + +G LA +D + + S E V L ++Q + Sbjct: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAVKA 360 Query: 267 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWD-FYSM 325 + W C SN ++A+ G+S + IW SG + ++ A ++ I W Y Sbjct: 361 VAW-CPWQSN-----VLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSPHYKE 413 Query: 326 SIVSNGFESGNVYVW 340 I +GF + +W Sbjct: 414 LISGHGFAQNQLVIW 428 Score = 28.9 bits (63), Expect = 4.1, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 27/56 (48%), Gaps = 4/56 (7%) Query: 44 GCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 G A LVI+ T + L H + S+ SPDG + +++ D +++LW Sbjct: 419 GFAQNQLVIWKYPTMAKVA----ELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 28.9 bits (63), Expect = 5.0, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 20/40 (50%), Gaps = 4/40 (10%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKP 107 L H + + + W+PDGR L + D + +W PS P Sbjct: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAP 340 >5UZ7-B nrPDB Length = 351 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 8/77 (10%) Query: 34 FSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH---VRPITSIAWSPDGRLLLTS 90 F P G+ A G + ++D+ + + M +H + ITS+++S GRLLL Sbjct: 245 FFPNGNAFATGSDDATCRLFDLRADQEL-----MTYSHDNIICGITSVSFSKSGRLLLAG 299 Query: 91 SRDWSIKLWDLSKPSKP 107 D++ +WD K + Sbjct: 300 YDDFNCNVWDALKADRA 316 Score = 31.2 bits (69), Expect = 0.83, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 22/114 (19%) Query: 4 LLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGAL--VIYDMDTFRPI 61 LLQ L++ E+L + I + + CA+ L + ++D I Sbjct: 10 LLQSELDQLRQEAEQLKNQIRDARKA---------------CADATLSQITNNIDPVGRI 54 Query: 62 CV-PGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSK----PLKE 110 + L H+ I ++ W D RLL+++S+D + +WD +K PL+ Sbjct: 55 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS 108 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 37/79 (46%), Gaps = 4/79 (5%) Query: 26 PLRTE---CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 PLR+ ++P G+Y+A G + IY++ T L H ++ + Sbjct: 105 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 164 Query: 83 DGRLLLTSSRDWSIKLWDL 101 D + ++TSS D + LWD+ Sbjct: 165 DNQ-IVTSSGDTTCALWDI 182 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 12/31 (38%), Positives = 20/31 (64%) Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDL 101 H + S++ +PD RL ++ + D S KLWD+ Sbjct: 194 HTGDVMSLSLAPDTRLFVSGACDASAKLWDV 224 >4N14-A nrPDB Length = 314 Score = 32.7 bits (73), Expect = 0.32, Method: Compositional matrix adjust. Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 9/135 (6%) Query: 207 IHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINK 266 + +L S + L + +G LA +D + + S E V L ++Q + Sbjct: 139 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAVKA 197 Query: 267 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWD-FYSM 325 + W C SN ++A+ G+S + IW SG + ++ A ++ I W Y Sbjct: 198 VAW-CPWQSN-----VLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSPHYKE 250 Query: 326 SIVSNGFESGNVYVW 340 I +GF + +W Sbjct: 251 LISGHGFAQNQLVIW 265 Score = 28.9 bits (63), Expect = 4.3, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 20/40 (50%), Gaps = 4/40 (10%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKP 107 L H + + + W+PDGR L + D + +W PS P Sbjct: 142 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAP 177 Score = 27.7 bits (60), Expect = 9.1, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 27/56 (48%), Gaps = 4/56 (7%) Query: 44 GCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 G A LVI+ T + L H + S+ SPDG + +++ D +++LW Sbjct: 256 GFAQNQLVIWKYPTMAKVA----ELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 >5M89-A nrPDB Length = 329 Score = 32.7 bits (73), Expect = 0.33, Method: Compositional matrix adjust. Identities = 20/69 (28%), Positives = 30/69 (43%), Gaps = 14/69 (20%) Query: 37 CGDYLALGCANGALVIYDMD----TFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 G + +G A G + +YD TF+ H P+T +A P GR+L + Sbjct: 101 TGTKVVIGTAKGWVKVYDAGRESATFQ----------THAGPVTGLAVHPGGRILASVGV 150 Query: 93 DWSIKLWDL 101 D S +DL Sbjct: 151 DKSFVFYDL 159 >4GGA-A nrPDB Length = 420 Score = 32.7 bits (73), Expect = 0.35, Method: Compositional matrix adjust. Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 9/135 (6%) Query: 207 IHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINK 266 + +L S + L + +G LA +D + + S E V L ++Q + Sbjct: 223 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAVKA 281 Query: 267 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWD-FYSM 325 + W C SN ++A+ G+S + IW SG + ++ A ++ I W Y Sbjct: 282 VAW-CPWQSN-----VLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSPHYKE 334 Query: 326 SIVSNGFESGNVYVW 340 I +GF + +W Sbjct: 335 LISGHGFAQNQLVIW 349 Score = 29.3 bits (64), Expect = 3.4, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 20/40 (50%), Gaps = 4/40 (10%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKP 107 L H + + + W+PDGR L + D + +W PS P Sbjct: 226 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAP 261 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 27/56 (48%), Gaps = 4/56 (7%) Query: 44 GCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 G A LVI+ T + L H + S+ SPDG + +++ D +++LW Sbjct: 340 GFAQNQLVIWKYPTMAKVA----ELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 >6HHQ-h nrPDB Length = 319 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 27/91 (29%), Positives = 38/91 (41%), Gaps = 7/91 (7%) Query: 16 PEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVI-----YDMDTFRPICVPGNMLGA 70 +K +T+ L FSP +LA A G V Y +D RP G A Sbjct: 227 AKKAMYTLSAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRP-EFAGYSKAA 285 Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDL 101 + S+AWS DG+ L D I++W + Sbjct: 286 EPHAV-SLAWSADGQTLFAGYTDNVIRVWQV 315 Score = 28.9 bits (63), Expect = 4.0, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 20/33 (60%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 H I ++ SPDG L+ ++ +D I LW+L+ Sbjct: 194 GHNSNINTLTASPDGTLIASAGKDGEIMLWNLA 226 >4U1E-I nrPDB Length = 347 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 20/32 (62%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 L H RP+T + ++ +G LL + S+D S +W Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVW 37 Score = 32.0 bits (71), Expect = 0.53, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 4/83 (4%) Query: 35 SPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDW 94 S G Y+ G +G + YD+ + + H + I+ + +SPD +TSSRD Sbjct: 162 STKGKYIIAGHKDGKISKYDVSNNYEYV---DSIDLHEKSISDMQFSPDLTYFITSSRDT 218 Query: 95 SIKLWDLSKPSKPLKEIRFDSPI 117 + L D+S + LK+ D P+ Sbjct: 219 NSFLVDVSTL-QVLKKYETDCPL 240 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 45/95 (47%), Gaps = 14/95 (14%) Query: 22 TIENPLRTECLQFSPCGDYLALGCAN-----GALVIYDMD----TFRPICV---PGNMLG 69 T ++P+ + ++FSPCG+Y N G++ IY+++ T V P + + Sbjct: 89 TWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKII 148 Query: 70 AH--VRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 H + T WS G+ ++ +D I +D+S Sbjct: 149 THEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVS 183 >5LCW-Q nrPDB Length = 374 Score = 32.3 bits (72), Expect = 0.37, Method: Compositional matrix adjust. Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 9/135 (6%) Query: 207 IHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINK 266 + +L S + L + +G LA +D + + S E V L ++Q + Sbjct: 177 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGAVKA 235 Query: 267 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWD-FYSM 325 + W C SN ++A+ G+S + IW SG + ++ A ++ I W Y Sbjct: 236 VAW-CPWQSN-----VLATGGGTSDRHIRIWNVCSGACLSAVD-AHSQVCSILWSPHYKE 288 Query: 326 SIVSNGFESGNVYVW 340 I +GF + +W Sbjct: 289 LISGHGFAQNQLVIW 303 Score = 28.9 bits (63), Expect = 4.1, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 20/40 (50%), Gaps = 4/40 (10%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKP 107 L H + + + W+PDGR L + D + +W PS P Sbjct: 180 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAP 215 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 27/56 (48%), Gaps = 4/56 (7%) Query: 44 GCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 G A LVI+ T + L H + S+ SPDG + +++ D +++LW Sbjct: 294 GFAQNQLVIWKYPTMAKVA----ELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 >5OQL-d nrPDB Length = 446 Score = 32.0 bits (71), Expect = 0.49, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 29/59 (49%), Gaps = 3/59 (5%) Query: 41 LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 LA+ + + I+D F N+ HV + + +SP G L++ S D +I+LW Sbjct: 255 LAVASEDHNIYIFDARNFDKAL---NIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLW 310 Score = 28.9 bits (63), Expect = 4.5, Method: Compositional matrix adjust. Identities = 16/68 (23%), Positives = 32/68 (47%), Gaps = 3/68 (4%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 ++FSP G+ L G + + ++ D V ++ + W+ D + +LT S Sbjct: 289 VEFSPTGEELVSGSYDRTIRLWRRDAGHSRDV---YHTKRMQRVFRTMWTMDSKYILTGS 345 Query: 92 RDWSIKLW 99 D +++LW Sbjct: 346 DDGNVRLW 353 >4BTS-AR nrPDB Length = 343 Score = 32.0 bits (71), Expect = 0.52, Method: Compositional matrix adjust. Identities = 26/123 (21%), Positives = 54/123 (43%), Gaps = 17/123 (13%) Query: 2 NILLQDPFAVLKE--HPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMD--- 56 NIL + F+ ++ H + ++ +P+ + P Y A +G L +++ + Sbjct: 146 NILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNFQI 205 Query: 57 --TFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFD 114 TF+ AH + ++ SP+G+ + T +D + +WD+ + P +E Sbjct: 206 RYTFK----------AHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAG 255 Query: 115 SPI 117 S I Sbjct: 256 STI 258 Score = 32.0 bits (71), Expect = 0.54, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 26/46 (56%), Gaps = 6/46 (13%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDS 115 H + S+A+SPD R +L++ + IKLW++ L E +F S Sbjct: 116 GHQSEVYSVAFSPDNRQILSAGAEREIKLWNI------LGECKFSS 155 >6F1U-h nrPDB Length = 612 Score = 32.0 bits (71), Expect = 0.52, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 42/105 (40%), Gaps = 15/105 (14%) Query: 15 HPE---KLTHTIENPLRTECLQFSPCGDY--LALGCANGALVIYDMDTFRPICVPGNMLG 69 HP+ +L H + + F P GD +G G+ +Y M Sbjct: 391 HPQDSMELVHKQSKAVAVTSMSF-PVGDVNNFVVGSEEGS--VYTACRHGSKAGISEMFE 447 Query: 70 AHVRPITSIAWSPD------GRLLLTSSRDWSIKLWDLSKPSKPL 108 H PIT I L +TSS DW++KLW +K +KPL Sbjct: 448 GHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWS-TKNNKPL 491 >5K1B-B nrPDB Length = 677 Score = 31.6 bits (70), Expect = 0.68, Method: Compositional matrix adjust. Identities = 23/94 (24%), Positives = 36/94 (38%), Gaps = 4/94 (4%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 L + G + G L ++D T C L H + ++ + DG L+ S Sbjct: 174 LAMNQLGTIIVSGSTEKVLRVWDPRT----CAKLMKLKGHTDNVKALLLNRDGTQCLSGS 229 Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 D +I+LW L + D +W Q DA Sbjct: 230 SDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDA 263 >2HXV-A nrPDB Length = 360 Score = 31.6 bits (70), Expect = 0.75, Method: Compositional matrix adjust. Identities = 13/43 (30%), Positives = 23/43 (53%) Query: 317 DINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVE 359 D+ + FYS I G + + Y+ V +PPK+ + +F + E Sbjct: 307 DVVFGFYSTKIFGKGLDVFSGYLSDVSVPPKFKVVNVEFSDSE 349 >2J04-A nrPDB Length = 588 Score = 31.2 bits (69), Expect = 0.84, Method: Compositional matrix adjust. Identities = 30/128 (23%), Positives = 53/128 (41%), Gaps = 7/128 (5%) Query: 35 SPCGDYLALGCANGALVIY-DMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRD 93 SP D++A+ NG + ++ D + GN+ R W+P ++ + D Sbjct: 94 SPIDDWMAVLSNNGNVSVFKDNKMLTNLDSKGNLSS---RTYHCFEWNPIESSIVVGNED 150 Query: 94 WSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL 153 ++ + + K S+ E F+S I + DA + V I D V SN+ V S+ Sbjct: 151 GELQFFSIRKNSENTPEFYFESSI---RLSDAGSKDWVTHIVWYEDVLVAALSNNSVFSM 207 Query: 154 LSKSDEKQ 161 + Q Sbjct: 208 TVSASSHQ 215 >5WLC-LN nrPDB Length = 776 Score = 31.2 bits (69), Expect = 0.85, Method: Compositional matrix adjust. Identities = 16/65 (24%), Positives = 30/65 (46%), Gaps = 1/65 (1%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKL 98 D L++GC NG +V+ D+ + +L + ++AW D ++ D I++ Sbjct: 154 DKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDD-FVIGGCSDGRIRI 212 Query: 99 WDLSK 103 W K Sbjct: 213 WSAQK 217 >2HES-X nrPDB Length = 330 Score = 31.2 bits (69), Expect = 0.86, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 20/34 (58%) Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 100 ++ H + +AWS DG L T SRD S+ +W+ Sbjct: 102 IIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWE 135 Score = 28.9 bits (63), Expect = 4.3, Method: Compositional matrix adjust. Identities = 12/30 (40%), Positives = 17/30 (56%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 AH + I S+AW P LL S D ++ +W Sbjct: 56 AHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85 Score = 28.1 bits (61), Expect = 8.0, Method: Compositional matrix adjust. Identities = 22/93 (23%), Positives = 44/93 (47%), Gaps = 10/93 (10%) Query: 7 DPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGN 66 D A+++ H EN ++ + +S G YLA + ++ I++ D + Sbjct: 98 DLLAIIEGH--------ENEVKG--VAWSNDGYYLATCSRDKSVWIWETDESGEEYECIS 147 Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 +L H + + + W P LL +SS D ++++W Sbjct: 148 VLQEHSQDVKHVIWHPSEALLASSSYDDTVRIW 180 >3JB9-S nrPDB Length = 488 Score = 31.2 bits (69), Expect = 0.90, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 52/114 (45%), Gaps = 9/114 (7%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 LQ P G+YL L +N I+ + + V + H ITS+A PDG L + Sbjct: 301 LQAHPSGEYL-LAASNEKCYIFSLKS----QVYNITVAQH---ITSLAVHPDGNLFVAGL 352 Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDF 145 + ++ ++ S ++ K SP+ Q+ + L V T ++SD ++ D Sbjct: 353 ENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTT-NDDSDIFIWDL 405 >5XYI-g nrPDB Length = 335 Score = 31.2 bits (69), Expect = 0.93, Method: Compositional matrix adjust. Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 6/76 (7%) Query: 41 LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 100 +A+GC +G + I+ ++ + AH TS+ ++PDG+ ++T D + +W Sbjct: 182 IAVGCWDGKVYIWSIEKEAKLI---KEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWL 238 Query: 101 LSKPSKPLKEIRFDSP 116 + K I F +P Sbjct: 239 TENGA---KTISFTAP 251 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 34/65 (52%), Gaps = 1/65 (1%) Query: 39 DYLALGCANGALVIYDMD-TFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK 97 +YL + + +++ ++ T P L H ++ ++ S D LLTSS D +++ Sbjct: 46 NYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLLTSSWDSTLR 105 Query: 98 LWDLS 102 LWDLS Sbjct: 106 LWDLS 110 >5WLC-SG nrPDB Length = 573 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 12/34 (35%), Positives = 19/34 (55%) Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 N H I ++A SPDG+ ++T RD + +W Sbjct: 230 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVW 263 >6CHG-A nrPDB Length = 312 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 19/32 (59%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 L H P+ SI ++ G +L +SS D SIK W Sbjct: 91 LMGHTAPVISICYNNKGNILCSSSMDESIKEW 122 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 36/154 (23%), Positives = 62/154 (40%), Gaps = 44/154 (28%) Query: 222 VSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWN----CI----- 272 +S +GE +AI C + + YEIS + ++LT HK + IN L W+ CI Sbjct: 21 ISPDGELIAI-CQNTDMLVYEIS---SSKMMKLTTTHK--ECINCLCWSPDSKCIASGSE 74 Query: 273 --------------------------LFSNNTAEYLVASTHGSSAHELYIWETTSGTLVR 306 + NN L +S+ S E W SGT ++ Sbjct: 75 DFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKE---WHVLSGTALK 131 Query: 307 VLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 + + ++ I+ + SI+S+G G + ++ Sbjct: 132 TMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIF 165 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 22/32 (68%) Query: 72 VRPITSIAWSPDGRLLLTSSRDWSIKLWDLSK 103 V PI+++ +S +G+ LL S D +KLW+ ++ Sbjct: 188 VVPISTVKFSRNGKFLLVKSLDNVVKLWEYTR 219 >6QDV-o nrPDB Length = 513 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 5/70 (7%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-DGRLLLTS 90 + FSP Y+ G NG L I+D T + + AH + W P + ++T Sbjct: 448 VDFSPDMSYVISGDGNGKLNIWDWKTTKLY----SRFKAHDKVCIGAVWHPHETSKVITC 503 Query: 91 SRDWSIKLWD 100 D IKLWD Sbjct: 504 GWDGLIKLWD 513 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 29/54 (53%), Gaps = 7/54 (12%) Query: 366 EKEDEFDEVDEAEQQQGLEQEEEIAID---LRTREQYDVRGNNLLVERFTIPTD 416 E++ E DE+ Q++G ++EE+ + L +E YD +G + L IP D Sbjct: 145 EEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYL----HIPQD 194 Score = 27.7 bits (60), Expect = 9.7, Method: Compositional matrix adjust. Identities = 24/101 (23%), Positives = 43/101 (42%), Gaps = 24/101 (23%) Query: 70 AHVRPITSIAWSP-DGRLLLTSSRDWSIKLWDLSKP----------SKPLKEIRFDSPIW 118 H + ++++ P G LLL+ S D IKLW++ SK +++I F++ Sbjct: 220 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTA-- 277 Query: 119 GCQWL-----------DAKRRLCVATIFEESDAYVIDFSND 148 G Q+L D + C++ Y + F+ D Sbjct: 278 GTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPD 318 >4J0X-A nrPDB Length = 451 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 1/46 (2%) Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI 111 N H I ++A SPDG+ ++T RD + +W S P+K I Sbjct: 108 NTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLS-PVKVI 152 >2X26-A nrPDB Length = 308 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 18/60 (30%), Positives = 27/60 (45%), Gaps = 9/60 (15%) Query: 283 VASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 VA GSS+H L L+R L A + DI + + + F+ GNV W++ Sbjct: 108 VAFQKGSSSHNL---------LLRALRQAGLKFTDIQPTYLTPADARAAFQQGNVDAWAI 158 >5YZG-W nrPDB Length = 579 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 5/70 (7%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-DGRLLLTS 90 + FSP Y+ G NG L I+D T + + AH + W P + ++T Sbjct: 514 VDFSPDMSYVISGDGNGKLNIWDWKTTKLY----SRFKAHDKVCIGAVWHPHETSKVITC 569 Query: 91 SRDWSIKLWD 100 D IKLWD Sbjct: 570 GWDGLIKLWD 579 Score = 28.9 bits (63), Expect = 4.1, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 29/54 (53%), Gaps = 7/54 (12%) Query: 366 EKEDEFDEVDEAEQQQGLEQEEEIAID---LRTREQYDVRGNNLLVERFTIPTD 416 E++ E DE+ Q++G ++EE+ + L +E YD +G + L IP D Sbjct: 211 EEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYL----HIPQD 260 >5K0Y-T nrPDB Length = 329 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 23/41 (56%), Gaps = 5/41 (12%) Query: 59 RPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 RPI +L H R IT I ++ +G LL T ++D + +W Sbjct: 2 RPI-----LLQGHERSITQIKYNREGDLLFTVAKDPIVNVW 37 >3JAP-g nrPDB Length = 326 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 9/77 (11%) Query: 31 CLQFSPCGDYLALGCANGALVIYDM------DTFRPICVPGNMLGAHVRPITSIAWSPDG 84 L FSP +L A+G + IYD+ D +P A S+AWS DG Sbjct: 249 ALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKPEFA--GYTKAQDPHAVSLAWSADG 305 Query: 85 RLLLTSSRDWSIKLWDL 101 + L D I++W + Sbjct: 306 QTLFAGYTDNVIRVWQV 322 >6N8P-A nrPDB Length = 979 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 38/137 (27%), Positives = 66/137 (48%), Gaps = 18/137 (13%) Query: 10 AVLKEHPEKLTHTIENPLRTECLQFSPC-GDYLALGCANGALVIYDMDTFRPICVPGNML 68 AVL+ PE+ H + E LQ P + + +G + G +VI+D+ R + + L Sbjct: 162 AVLQRLPEEARHRRVFEM-VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLY---HFL 217 Query: 69 GAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSK---PLKEIRFDSPIWGCQ---- 121 + + + +I W DGRLL++ D S W +S ++ PL+ + P + C+ Sbjct: 218 SS--QQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGP-FPCKAITR 274 Query: 122 --WLDAKRRLCVATIFE 136 WL ++ L TIF+ Sbjct: 275 ILWLTTRQGLPF-TIFQ 290 Score = 28.5 bits (62), Expect = 6.1, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%) Query: 18 KLTHTIEN--PLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPG-NMLGAHVR- 73 + T+E+ P + L +SP LA+G +GA+ +Y PG +G H Sbjct: 11 QFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYG--------APGVEFMGLHQEN 62 Query: 74 -PITSIAWSPDGRLLLTSSRDWSIKLWDL 101 +T I P L+T D S+ LW L Sbjct: 63 NAVTQIHLLPGQCQLVTLLDDNSLHLWSL 91 >3DW8-B nrPDB Length = 447 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 13/39 (33%), Positives = 27/39 (69%), Gaps = 3/39 (7%) Query: 72 VRPITSIAWSPDGRLLLTSSRDW-SIKLWDLSKPSKPLK 109 + I+ + +S GR ++T RD+ S+K+WDL+ ++P++ Sbjct: 285 ISSISDVKFSHSGRYMMT--RDYLSVKVWDLNMENRPVE 321 >5L9T-R nrPDB Length = 493 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 42/195 (21%), Positives = 75/195 (38%), Gaps = 16/195 (8%) Query: 51 VIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKE 110 +I D P L H + + + WS D +LL + D + +W+ S S + Sbjct: 292 MILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY 351 Query: 111 IRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGY 170 + + W + L +A+ +D I F N L D G Sbjct: 352 TEHLAAVKAIAWSPHQHGL-LASGGGTAD-RCIRFWNTLTGQPL---------QCIDTGS 400 Query: 171 VLVCTVHTKHPNIIIV--GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGER 228 + +KH N ++ G S+ + +K+ SL Q + L S + +L +S +GE Sbjct: 401 QVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQ---VAKLTGHSYRVLYLAMSPDGEA 457 Query: 229 LAINCSDRTIRQYEI 243 + D T+R + + Sbjct: 458 IVTGAGDETLRFWNV 472 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 12/43 (27%), Positives = 24/43 (55%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKE 110 L H + +A SPDG ++T + D +++ W++ ++ KE Sbjct: 439 LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKE 481 >5K1H-B nrPDB Length = 576 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 31/68 (45%), Gaps = 9/68 (13%) Query: 34 FSPCGDYLALG---CANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 +SP G ++ L NGAL D C N+ ++ + + W P GR ++TS Sbjct: 447 WSPQGQFVVLAGLRSMNGALAFVDTSD----CTVMNIAEHYM--ASDVEWDPTGRYVVTS 500 Query: 91 SRDWSIKL 98 WS K+ Sbjct: 501 VSWWSHKV 508 >4AV8-A nrPDB Length = 339 Score = 28.5 bits (62), Expect = 5.1, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 35/77 (45%), Gaps = 3/77 (3%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 NP++ ++ + GD +A C+ +I T + V G I + WSPDG Sbjct: 180 NPVKM--VRLNRKGDMVAT-CSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDG 236 Query: 85 RLLLTSSRDWSIKLWDL 101 L S W++ ++++ Sbjct: 237 SKLAVVSDKWTLHVFEV 253 >5OQJ-7 nrPDB Length = 843 Score = 28.5 bits (62), Expect = 5.4, Method: Compositional matrix adjust. Identities = 20/79 (25%), Positives = 33/79 (41%), Gaps = 5/79 (6%) Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV-IDFSNDPV 150 RD + L KP K K R + +DAK + + +++++ + DF D V Sbjct: 54 RDTGAMVTGLKKPRKKTKSSRHTAADSSMNQMDAKDK----ALLQDTNSDIPADFVPDSV 109 Query: 151 ASLLSKSDEKQLSSTPDHG 169 + + D L PDH Sbjct: 110 SGMFRSHDFSYLRLRPDHA 128 >5SVA-Z nrPDB Length = 843 Score = 28.5 bits (62), Expect = 5.5, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 30/78 (38%), Gaps = 3/78 (3%) Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVA 151 RD + L KP K K R + +DAK + A + + + DF D V+ Sbjct: 54 RDTGAMVTGLKKPRKKTKSSRHTAADSSMNQMDAKDK---ALLQDTNSDIPADFVPDSVS 110 Query: 152 SLLSKSDEKQLSSTPDHG 169 + D L PDH Sbjct: 111 GMFRSHDFSYLRLRPDHA 128 >5CWW-B nrPDB Length = 595 Score = 28.5 bits (62), Expect = 5.9, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 40/94 (42%), Gaps = 5/94 (5%) Query: 158 DEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY----KFHSLYQTECIHSLKIT 213 D +QL +P+ ++ V T HT H I+ + D KF +L T + S Sbjct: 116 DIRQLVMSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSRSAV 175 Query: 214 SSNIKHLIVSQNGERLAINCSDRTIRQYEISIDD 247 S + H + NG L D +R +E+S D Sbjct: 176 VSAVWHPL-GVNGHALVTVTEDAIVRVWELSTAD 208 >5AJA-A nrPDB Length = 361 Score = 28.1 bits (61), Expect = 7.5, Method: Compositional matrix adjust. Identities = 23/68 (33%), Positives = 31/68 (45%), Gaps = 5/68 (7%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 C FS +L LG G L +Y++ + + H IT + S DG LLLTS Sbjct: 42 CCAFSARERFLMLGTCTGQLKLYNVFSGQEEAS----YNCHNSAITHLEPSRDGSLLLTS 97 Query: 91 SRDWSIKL 98 + WS L Sbjct: 98 AT-WSQPL 104 >5OQL-L nrPDB Length = 557 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 15/65 (23%), Positives = 35/65 (53%), Gaps = 5/65 (7%) Query: 36 PCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWS 95 P G L L + A+ + D+ +P+ ++ H + +TS++ + GR +++ S D Sbjct: 242 PSGTTL-LAASGNAISVLDLVAAKPL----RLITNHQKTVTSLSLASQGRRVVSGSLDGH 296 Query: 96 IKLWD 100 +K+++ Sbjct: 297 VKVFE 301 >4J0W-A nrPDB Length = 343 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 18/75 (24%), Positives = 37/75 (49%), Gaps = 4/75 (5%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 C+ S G YLA G + ++I++ + C H ++ +A+ L ++ Sbjct: 72 CMAISSDGKYLASGDRSKLILIWEAQS----CQHLYTFTGHRDAVSGLAFRRGTHQLYST 127 Query: 91 SRDWSIKLWDLSKPS 105 S D S+K+W++++ S Sbjct: 128 SHDRSVKVWNVAENS 142 >3IYO-A nrPDB Length = 660 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 2/54 (3%) Query: 267 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINW 320 L+ N +L+ + TA ST+GSS +Y+ ++ TLV V GA+ ++W Sbjct: 465 LRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSV--TLVNVATGAQAVARSLDW 516 >5Z57-K nrPDB Length = 225 Score = 28.1 bits (61), Expect = 7.9, Method: Compositional matrix adjust. Identities = 28/118 (23%), Positives = 49/118 (41%), Gaps = 25/118 (21%) Query: 283 VASTHGSSAHELYIWETTSGTLVRVLEGAEEEL-------IDINWDFYSMSIVSNGFESG 335 + S HG +A W+ + LV ++E A++EL D+NW +M + + Sbjct: 126 LMSQHGCNA-----WKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLRE 180 Query: 336 NVYVWSVVIPPKWSALAPDFEEVEENVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDL 393 + W +L E+E + LE +E+ + +QQ G +E I D Sbjct: 181 --------MESNWVSLVSKNYEIERTIVQLE-----NEIYQIKQQHGEANKENIRQDF 225 >3JZG-A nrPDB Length = 402 Score = 28.1 bits (61), Expect = 8.0, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 25/48 (52%), Gaps = 3/48 (6%) Query: 289 SSAHELYIWETTSGTLVRV---LEGAEEELIDINWDFYSMSIVSNGFE 333 S H L +W + TLV + +EG +E++ ++D I+S G + Sbjct: 171 SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMD 218 >3M6A-A nrPDB Length = 543 Score = 28.1 bits (61), Expect = 8.4, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 23/49 (46%) Query: 120 CQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDH 168 Q + +L + +E D DF DP +++L D +Q SS DH Sbjct: 166 IQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSFSDH 214 >2ZZQ-A nrPDB Length = 552 Score = 28.1 bits (61), Expect = 8.6, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 2/54 (3%) Query: 267 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINW 320 L+ N +L+ + TA ST+GSS +Y+ ++ TLV V GA+ ++W Sbjct: 409 LRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSV--TLVNVATGAQAVARSLDW 460 >4AEZ-A nrPDB Length = 401 Score = 27.7 bits (60), Expect = 8.8, Method: Compositional matrix adjust. Identities = 13/30 (43%), Positives = 19/30 (63%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 AH + A SPDGR+L T++ D ++K W Sbjct: 347 AHDTRVLYSALSPDGRILSTAASDENLKFW 376 Score = 27.7 bits (60), Expect = 9.8, Method: Compositional matrix adjust. Identities = 23/128 (17%), Positives = 45/128 (35%), Gaps = 37/128 (28%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDT-------------------FRPICVPGNMLGA-- 70 +++S G +L++G NG + IYD+++ R + G+ GA Sbjct: 140 VKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIH 199 Query: 71 ----------------HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFD 114 H + +AW DG L + D +++WD + + Sbjct: 200 HHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHN 259 Query: 115 SPIWGCQW 122 + + W Sbjct: 260 AAVKAVAW 267 >3I2N-A nrPDB Length = 357 Score = 27.7 bits (60), Expect = 9.0, Method: Compositional matrix adjust. Identities = 14/35 (40%), Positives = 25/35 (71%), Gaps = 1/35 (2%) Query: 73 RPITSIAWSPDGR-LLLTSSRDWSIKLWDLSKPSK 106 +PI+S+ WSPD R L + SS D ++++ ++K +K Sbjct: 322 QPISSLDWSPDKRGLCVCSSFDQTVRVLIVTKLNK 356 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6BX3-B nrPDB 553 e-158 6CHG-D nrPDB 510 e-145 5OV3-A nrPDB 324 3e-89 6E29-D nrPDB 302 3e-82 6QX9-5O nrPDB 258 3e-69 3JB9-L nrPDB 233 1e-61 5NNZ-B nrPDB 225 3e-59 5M25-A nrPDB 222 2e-58 2H9P-A nrPDB 219 2e-57 5WLC-LO nrPDB 209 2e-54 5I2T-A nrPDB 209 2e-54 5MZH-A nrPDB 199 2e-51 5FVM-C nrPDB 197 6e-51 6EMK-B nrPDB 191 5e-49 6F3T-A nrPDB 167 7e-42 6MZM-G nrPDB 166 1e-41 5FL8-q nrPDB 162 2e-40 6HQA-B nrPDB 158 4e-39 3JB9-g nrPDB 136 2e-32 6BX3-A nrPDB 133 2e-31 4V8M-A7 nrPDB 124 7e-29 3FM0-A nrPDB 124 9e-29 5OPT-p nrPDB 119 3e-27 5Z56-q nrPDB 117 9e-27 4LG8-A nrPDB 114 5e-26 1NR0-A nrPDB 109 2e-24 5WYK-BB nrPDB 106 2e-23 6GMH-W nrPDB 105 4e-23 4OWR-A nrPDB 103 2e-22 5BPW-A nrPDB 102 2e-22 5WYJ-BE nrPDB 96 2e-20 3C9C-A nrPDB 92 4e-19 3CFV-B nrPDB 91 8e-19 5Y1U-A nrPDB 90 1e-18 3ACP-A nrPDB 76 4e-14 Sequences not found previously or not previously below threshold: 1VYH-C nrPDB 143 1e-34 6Q8F-A nrPDB 136 2e-32 6QX9-4B nrPDB 133 2e-31 5WBU-D nrPDB 131 4e-31 5YZG-W nrPDB 120 1e-27 6QDV-o nrPDB 120 1e-27 3DM0-A nrPDB 119 2e-27 6CHG-A nrPDB 119 2e-27 6G51-g nrPDB 117 1e-26 6N9G-C nrPDB 116 3e-26 4BTS-AR nrPDB 116 3e-26 5NZU-C nrPDB 115 3e-26 4V6W-Ag nrPDB 114 6e-26 4V7E-Bg nrPDB 112 2e-25 6ID0-T nrPDB 111 6e-25 5Y88-O nrPDB 111 7e-25 2HES-X nrPDB 110 9e-25 5UZ7-B nrPDB 109 3e-24 5K1B-B nrPDB 109 3e-24 5GAN-H nrPDB 107 9e-24 6HHQ-h nrPDB 107 9e-24 6EOJ-D nrPDB 103 2e-22 3MKQ-A nrPDB 101 5e-22 2YNP-A nrPDB 100 1e-21 5WYJ-BC nrPDB 100 3e-21 5XYI-g nrPDB 99 3e-21 5L9T-R nrPDB 99 4e-21 6J6H-n nrPDB 97 2e-20 5OQL-J nrPDB 96 2e-20 5OQL-L nrPDB 95 4e-20 5G04-R nrPDB 95 5e-20 5BPT-A nrPDB 95 7e-20 4GGA-A nrPDB 94 1e-19 5LCW-Q nrPDB 94 1e-19 4L9O-A nrPDB 94 1e-19 3JRO-A nrPDB 93 2e-19 5CXC-A nrPDB 92 4e-19 5K0Y-T nrPDB 92 5e-19 4N14-A nrPDB 91 7e-19 4J0W-A nrPDB 91 9e-19 3JRP-A nrPDB 90 2e-18 5OQL-d nrPDB 90 2e-18 3JAP-g nrPDB 90 2e-18 4A11-B nrPDB 90 3e-18 4BZK-B nrPDB 89 5e-18 5WJC-A nrPDB 88 5e-18 4YCZ-A nrPDB 88 6e-18 4AEZ-A nrPDB 86 2e-17 3BG0-A nrPDB 85 8e-17 5WLC-LU nrPDB 84 1e-16 5MWJ-A nrPDB 81 6e-16 5A31-R nrPDB 81 7e-16 3F3P-A nrPDB 81 9e-16 4BH6-A nrPDB 80 2e-15 6ELZ-p nrPDB 78 6e-15 5N4A-A nrPDB 77 1e-14 4XYI-A nrPDB 75 8e-14 5A9Q-7 nrPDB 74 1e-13 4XFV-A nrPDB 73 3e-13 3ODT-A nrPDB 69 2e-12 4E5Z-B nrPDB 69 3e-12 5OQL-X nrPDB 69 4e-12 5WLC-LJ nrPDB 68 5e-12 5FA5-B nrPDB 68 1e-11 5TF2-A nrPDB 68 1e-11 4J0X-A nrPDB 68 1e-11 2AQ5-A nrPDB 67 1e-11 1PI6-A nrPDB 67 1e-11 4U1E-I nrPDB 67 2e-11 5YZG-2 nrPDB 66 2e-11 4PSX-B nrPDB 66 3e-11 2PM9-A nrPDB 66 3e-11 5K19-A nrPDB 66 3e-11 6CB1-s nrPDB 66 4e-11 5WLC-SG nrPDB 66 4e-11 2P9P-C nrPDB 66 4e-11 6C0F-s nrPDB 64 1e-10 4G56-B nrPDB 64 2e-10 6EM1-m nrPDB 63 2e-10 3JB9-S nrPDB 61 8e-10 5CXB-B nrPDB 61 8e-10 3W15-A nrPDB 61 1e-09 6F1U-h nrPDB 61 1e-09 6N8P-A nrPDB 60 2e-09 5M89-A nrPDB 59 3e-09 5A9Q-0 nrPDB 58 6e-09 5AJA-A nrPDB 58 6e-09 3JZG-A nrPDB 58 7e-09 5A9Q-2 nrPDB 58 9e-09 5WLC-LN nrPDB 58 9e-09 5WLC-LW nrPDB 56 3e-08 3EI3-B nrPDB 55 6e-08 6CVZ-A nrPDB 53 2e-07 5BJS-A nrPDB 53 4e-07 3DWL-C nrPDB 53 4e-07 3I2N-A nrPDB 52 5e-07 5MC6-j nrPDB 50 2e-06 5WLC-LH nrPDB 49 5e-06 5WLC-LS nrPDB 48 7e-06 3DW8-B nrPDB 48 1e-05 5WLC-LL nrPDB 46 4e-05 4AV8-A nrPDB 43 2e-04 6IYY-A nrPDB 42 4e-04 5LTD-A nrPDB 39 0.004 4NOX-A nrPDB 38 0.008 5OLJ-A nrPDB 38 0.009 5AMS-A nrPDB 38 0.009 2I3T-A nrPDB 38 0.010 3AZQ-A nrPDB 37 0.014 5WLC-LV nrPDB 37 0.014 5K1H-B nrPDB 37 0.015 4R40-A nrPDB 36 0.025 1J83-A nrPDB 33 0.19 6IGR-A nrPDB 33 0.19 1C5K-A nrPDB 33 0.20 1Z68-A nrPDB 33 0.33 4YHC-A nrPDB 32 0.41 2EEP-A nrPDB 32 0.68 4BFG-A nrPDB 31 1.0 6FYY-p nrPDB 31 1.4 5GRS-A nrPDB 30 1.5 4U1F-A nrPDB 30 1.7 6IOZ-A nrPDB 30 1.8 4QUV-A nrPDB 30 2.3 1FLG-A nrPDB 30 2.5 1KEU-A nrPDB 29 2.6 2VDU-B nrPDB 29 2.8 5VAQ-A nrPDB 29 2.8 >6BX3-B nrPDB Length = 412 Score = 553 bits (1424), Expect = e-158, Method: Composition-based stats. Identities = 412/412 (100%), Positives = 412/412 (100%) Query: 2 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI 61 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI Sbjct: 1 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI 60 Query: 62 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ Sbjct: 61 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 120 Query: 122 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 181 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP Sbjct: 121 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 180 Query: 182 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY Sbjct: 181 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 240 Query: 242 EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS 301 EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS Sbjct: 241 EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS 300 Query: 302 GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEEN 361 GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEEN Sbjct: 301 GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEEN 360 Query: 362 VDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERFTI 413 VDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERFTI Sbjct: 361 VDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERFTI 412 >6CHG-D nrPDB Length = 439 Score = 510 bits (1313), Expect = e-145, Method: Composition-based stats. Identities = 234/433 (54%), Positives = 308/433 (71%), Gaps = 13/433 (3%) Query: 2 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI 61 N+LLQDPF VLKE+PEKLTHT+E P+ C++FSP GDYLA+GC+NGA++IYDMD+ +PI Sbjct: 3 NLLLQDPFGVLKEYPEKLTHTLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPI 62 Query: 62 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 + G GAH R + S+ WS DGR L +S RDW KLWD+++P+K ++ +FD P+W C Sbjct: 63 AMLGTHSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCH 122 Query: 122 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 181 + +C+ T+ EE AYV+ + D + +Q HGY LV H Sbjct: 123 V--VRWNVCIVTVVEEPTAYVLTLT-DRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIE 179 Query: 182 NIIIVGTSKGWLDFYKFHSLYQTE----CIHSLKITSSNIKHLIVSQNGERLAINCSDRT 237 +III GTSKGW++ ++ E C + KI ++NIK +I+S +G R+AIN SDRT Sbjct: 180 SIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRT 239 Query: 238 IRQYEISIDDENSA------VELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSA 291 IRQY++ ++D S V + LEHKYQD+IN+LQWN I FSN++ EYLVAS HGSSA Sbjct: 240 IRQYQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSA 299 Query: 292 HELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSAL 351 H+LY+WET+SG+LVRVLEGA+EEL+DI+W+FYSM I SNGFESG VY+WS+VIPPKWSAL Sbjct: 300 HDLYLWETSSGSLVRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMWSIVIPPKWSAL 359 Query: 352 APDFEEVEENVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERF 411 APDFEEVEEN+DY EKE+EFD +D+ Q + + EEIAIDL T E+YDVRGN++ + F Sbjct: 360 APDFEEVEENIDYQEKENEFDIMDDDNNLQAMTEAEEIAIDLCTPEKYDVRGNDISMPSF 419 Query: 412 TIPTDYTRIIKMQ 424 IP DY +I Q Sbjct: 420 VIPIDYEGVIIQQ 432 >5OV3-A nrPDB Length = 381 Score = 324 bits (831), Expect = 3e-89, Method: Composition-based stats. Identities = 118/406 (29%), Positives = 190/406 (46%), Gaps = 40/406 (9%) Query: 2 NILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI 61 N+ L + F + +PE+ T++ F+ G LA+GC +G +VI+D T Sbjct: 3 NLELLESFG--QNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRG-- 58 Query: 62 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 ++ AH+ P+ S+ WS DG L+++S D + WD+ + RF SPI Q Sbjct: 59 --IAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCD-QRFRFPSPILKVQ 115 Query: 122 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 181 + +++ V + PV LS S L D +V + Sbjct: 116 YHPR----------DQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVA-SFDRRG 164 Query: 182 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSN-----IKHLIVSQNGERLAINCSDR 236 I G +KG + K S + + S ++T+ IK + ++ G IN +DR Sbjct: 165 EYIYTGNAKGKILVLKTDS---QDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADR 221 Query: 237 TIRQYE---ISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHE 293 IR Y+ I + E K QD++N+ W FS + EY+VA + + H Sbjct: 222 IIRVYDGREILTCGRDGEPEPM--QKLQDLVNRTPWKKCCFSGD-GEYIVAGS--ARQHA 276 Query: 294 LYIWETTSGTLVRVLEGAEEELI-DINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALA 352 LYIWE + G LV++L G EL+ D+ W + + + SG V +W+ WSA A Sbjct: 277 LYIWEKSIGNLVKILHGTRGELLLDVAW--HPVRPIIASISSGVVSIWAQNQVENWSAFA 334 Query: 353 PDFEEVEENVDYLEKEDEFDEVDEAE---QQQGLEQEEEIAIDLRT 395 PDF+E++ENV+Y E+E EFD DE + +Q G + E+ +D+ + Sbjct: 335 PDFKELDENVEYEERESEFDIEDEDKSEPKQTGADAAEDEEVDVTS 380 >6E29-D nrPDB Length = 345 Score = 302 bits (772), Expect = 3e-82, Method: Composition-based stats. Identities = 122/357 (34%), Positives = 196/357 (54%), Gaps = 29/357 (8%) Query: 1 MNILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRP 60 MN+LL D + +L+++PE +T+TI + T C++F+ GD+LA G +G +VI+D++T Sbjct: 2 MNLLLSDDY-LLQDYPENITNTIRSGHST-CVRFNRKGDFLASGRVDGTVVIWDLETMGV 59 Query: 61 ICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGC 120 L H + ITS++WS GR LL++ + W + LWDL + K +E+RF +P++G Sbjct: 60 ----ARKLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDL-QDGKRYREVRFRAPVYGA 114 Query: 121 QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHG----------- 169 + A +FE+ V D + + S K+ S+ D Sbjct: 115 ELHPWNHHQFAAALFEDQPMLV-DITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAK 173 Query: 170 YVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERL 229 ++ V+T + ++ GT+KG L+ E I+S KI S I L ++++G L Sbjct: 174 HMTTAIVYTASGDHLLAGTTKGRLNII---DARTREIIYSEKIASGIITTLRLTESGREL 230 Query: 230 AINCSDRTIRQYEI----SIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVAS 285 +N DR IR + + + D + ++L LEHK+QDV+N+L WN + FS T EY+ AS Sbjct: 231 LVNAQDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSA-TGEYVAAS 289 Query: 286 THGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 T+ + HELYIWE G+LVR+LEG +EE I W + + + G E+G + +WSV Sbjct: 290 TYNN--HELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSV 344 >6QX9-5O nrPDB Length = 357 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 62/335 (18%), Positives = 136/335 (40%), Gaps = 34/335 (10%) Query: 7 DPFAVLKEHPEKLTHT-------IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFR 59 P A+L+ P + + + C +F P G LA + ++++++ Sbjct: 40 TPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV---Y 96 Query: 60 PICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWG 119 C L H + + ++ DG +L ++S D ++ +WD S+ + +K ++ + Sbjct: 97 GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD-SETGERVKRLKGHTSFVN 155 Query: 120 CQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTK 179 + A+R V S+D L + + + + VL T + Sbjct: 156 SCY-PARR----------GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDT 204 Query: 180 HPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIR 239 II S G + K L Q + ++++ + ++ L +S G L N D T+R Sbjct: 205 SDQII----SGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVR 260 Query: 240 QYEIS-IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 298 +++ + V++ +Q ++ + N + S + +A+ GS+ +Y+W+ Sbjct: 261 VWDVRPFAPKERCVKI-----FQGNVHNFEKNLLRCSWSPDGSKIAA--GSADRFVYVWD 313 Query: 299 TTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFE 333 TTS ++ L G + ++ + I+S + Sbjct: 314 TTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 31/233 (13%), Positives = 77/233 (33%), Gaps = 24/233 (10%) Query: 112 RFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLS-KSDEKQLSSTPDHGY 170 +PI L F + + + D + L + D ++ H Sbjct: 54 SLQAPIM---LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG 110 Query: 171 VLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLA 230 ++ + +++ ++ + E + LK +S + ++ G +L Sbjct: 111 AVMELHYNTDGSMLFSASTDKTV---AVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV 167 Query: 231 -INCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGS 289 D T++ ++I + Q N Q + F++ + + + G Sbjct: 168 CTGSDDGTVKLWDIR-----------KKAAIQTFQNTYQVLAVTFNDTSDQII----SGG 212 Query: 290 SAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 +++ +W+ L + G + + ++ ++SN V VW V Sbjct: 213 IDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM-DNTVRVWDV 264 Score = 74.9 bits (182), Expect = 6e-14, Method: Composition-based stats. Identities = 25/124 (20%), Positives = 45/124 (36%), Gaps = 5/124 (4%) Query: 18 KLTHTIENPL-RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA--H--V 72 KLT+T+ L S G YL + + ++D+ F P + H Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285 Query: 73 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVA 132 + + +WSPDG + S D + +WD + K I + + + A Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345 Query: 133 TIFE 136 + + Sbjct: 346 SSDK 349 >3JB9-L nrPDB Length = 340 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 119/311 (38%), Gaps = 26/311 (8%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 + +F P G Y A G + ++++++ F + G + G IT + WS Sbjct: 47 FGHTAEVLVARFDPSGSYFASGGMDRQILLWNV--FGDVKNYGVLNGC-KGAITDLQWSR 103 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 D R++ SS D + WD K K + L L + ++ ++ V Sbjct: 104 DSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSEL-LTSVSDDCTMKV 162 Query: 143 IDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLY 202 D S K T + Y L + + +G G + K L Sbjct: 163 WD------------SRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAI---KIWDLR 207 Query: 203 QTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQD 262 C H LK I L +S++G L N D T+R +++ ++ + L ++ Sbjct: 208 NNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVK---PFASAQRQL-QIFEG 263 Query: 263 VINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDF 322 I+ + N + + + V + GSS +Y+W T G L VL G E + +++ Sbjct: 264 AIHGQEHNLLGVAWSRNSRFVGA--GSSDKNVYVWSAT-GDLRYVLPGHEGSVNHVDFHP 320 Query: 323 YSMSIVSNGFE 333 + I+S + Sbjct: 321 HQDIILSCSSD 331 Score = 58.7 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 23/133 (17%), Positives = 48/133 (36%), Gaps = 13/133 (9%) Query: 209 SLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQ 268 + ++ + +G A DR I + + D +N V + + I LQ Sbjct: 45 QMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGV----LNGCKGAITDLQ 100 Query: 269 WNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIV 328 W + +V + SS L W+ SG +R +G + ++ ++ Sbjct: 101 W-------SRDSRVVYCS--SSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELL 151 Query: 329 SNGFESGNVYVWS 341 ++ + + VW Sbjct: 152 TSVSDDCTMKVWD 164 >5NNZ-B nrPDB Length = 415 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 57/279 (20%), Positives = 106/279 (37%), Gaps = 32/279 (11%) Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 +L AH+ P+T++A + G +T S D + KLWD + + L+ Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEE-------------LNTLEG 132 Query: 126 KRRLCVATIFEES-DAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNII 184 R + A F + S D L S K + H +VC ++ Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192 Query: 185 IVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 244 G+ K + E +++L+ S+ I L + +G+R+ D T+ ++ Sbjct: 193 ATGSMDTTA---KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD-- 247 Query: 245 IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 304 D V + + H + W+C L GS +W+ T+G Sbjct: 248 -ADTGRKVNILIGHCAEISSASFNWDCSLILT-----------GSMDKTCKLWDATNGKC 295 Query: 305 VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 343 V L G ++E++D +D Y+ +++ G ++S Sbjct: 296 VATLTGHDDEILDSCFD-YTGKLIATASADGTARIFSAA 333 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 57/322 (17%), Positives = 114/322 (35%), Gaps = 37/322 (11%) Query: 21 HTIENPLRT-ECLQFS-PCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSI 78 +T+E + F+ P GD +A G + ++ ++T + + H I + Sbjct: 128 NTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK----CYHTFRGHTAEIVCL 183 Query: 79 AWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEES 138 +++P L+ T S D + KLWD+ + + ++ F S Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSA-------------EIISLSFNTS 230 Query: 139 DAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKF 198 +I S D + ++++ H + ++I+ G+ K Sbjct: 231 GDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMD---KTCKL 287 Query: 199 HSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEH 258 +C+ +L I G+ +A +D T R + + + H Sbjct: 288 WDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR---KCIAKLEGH 344 Query: 259 KYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDI 318 + + I F+ L GSS IW+ +G ++VLEG +E+ Sbjct: 345 EGEIS-------KISFNPQGNHLLT----GSSDKTARIWDAQTGQCLQVLEGHTDEIFSC 393 Query: 319 NWDFYSMSIVSNGFESGNVYVW 340 ++ Y +IV G + +W Sbjct: 394 AFN-YKGNIVITGSKDNTCRIW 414 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 47/281 (16%), Positives = 94/281 (33%), Gaps = 35/281 (12%) Query: 18 KLTHTIE-NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 K HT + CL F+P +A G + ++D+ + L H I Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY----TLRGHSAEII 223 Query: 77 SIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 S++++ G ++T S D ++ +WD K L + F Sbjct: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRK-------------VNILIGHCAEISSASFN 270 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY 196 + ++ S D L ++ K +++ H ++ + +I ++ G + Sbjct: 271 WDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF 330 Query: 197 KFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTL 256 S +CI L+ I + + G L SD+T R ++ +++ Sbjct: 331 ---SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD---AQTGQCLQVLE 384 Query: 257 EHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 H + F+ + GS + IW Sbjct: 385 GHTDEIFS-------CAFNYKGNIVIT----GSKDNTCRIW 414 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 38/202 (18%), Positives = 67/202 (33%), Gaps = 33/202 (16%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + L F+ GD + G + +V++D DT R + N+L H I+S +++ D Sbjct: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV----NILIGHCAEISSASFNWDC 273 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW---------------------- 122 L+LT S D + KLWD + D I + Sbjct: 274 SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAA 333 Query: 123 -------LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCT 175 L+ F +++ S+D A + + L H + Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSC 393 Query: 176 VHTKHPNIIIVGTSKGWLDFYK 197 NI+I G+ ++ Sbjct: 394 AFNYKGNIVITGSKDNTCRIWR 415 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 20/137 (14%), Positives = 50/137 (36%), Gaps = 14/137 (10%) Query: 206 CIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVIN 265 LK + ++ ++++G DRT + ++ + + + H+ Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGE---ELNTLEGHRNVVYA- 139 Query: 266 KLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSM 325 I F+N + + GS +W +G G E++ ++++ S Sbjct: 140 ------IAFNNPYGDKIAT---GSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS- 189 Query: 326 SIVSNGFESGNVYVWSV 342 ++V+ G +W + Sbjct: 190 TLVATGSMDTTAKLWDI 206 >5M25-A nrPDB Length = 434 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 70/339 (20%), Positives = 135/339 (39%), Gaps = 38/339 (11%) Query: 6 QDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPG 65 P V + K T + ++FSP G++LA A+ + I+ + Sbjct: 126 SKPTPVKPNYALKFT-LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE---- 180 Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 + H I+ +AWS D LL+++S D ++K+WD+S K LK ++ S C + Sbjct: 181 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNP 239 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 + L V+ F+ES + K L + P H + + ++I+ Sbjct: 240 QSNLIVSGSFDES------------VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 287 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSS-NIKHLIVSQNGERLAINCSDRTIRQYEIS 244 + G + +C+ +L + + + S NG+ + D T++ ++ S Sbjct: 288 SSSYDG---LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 344 Query: 245 IDDENSAVELTLEHKYQDVINKLQWNCIL--FSNNTAEYLVASTHGSSAHELYIWETTSG 302 + ++ HK + CI FS +++V+ GS + +YIW + Sbjct: 345 ---KGKCLKTYTGHKNEKY-------CIFANFSVTGGKWIVS---GSEDNLVYIWNLQTK 391 Query: 303 TLVRVLEGAEEELIDINWDFYSMSIVSNGFE-SGNVYVW 340 +V+ L+G + +I I S E + +W Sbjct: 392 EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 430 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 49/278 (17%), Positives = 107/278 (38%), Gaps = 31/278 (11%) Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 L H + ++S+ +SP+G L +SS D IK+W I W Sbjct: 140 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 199 Query: 127 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 186 ++ S+D + S K L + H + C N+I+ Sbjct: 200 N-------------LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 246 Query: 187 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISID 246 G+ + + + + +C+ +L S + + +++G + + D R ++ + Sbjct: 247 GS---FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS- 302 Query: 247 DENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVR 306 ++ ++ + + + FS N +Y++A+T + L +W+ + G ++ Sbjct: 303 --GQCLKTLIDD------DNPPVSFVKFSPN-GKYILAATL---DNTLKLWDYSKGKCLK 350 Query: 307 VLEGAEEE--LIDINWDFYSMSIVSNGFESGNVYVWSV 342 G + E I N+ + +G E VY+W++ Sbjct: 351 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 388 >2H9P-A nrPDB Length = 329 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 66/320 (20%), Positives = 130/320 (40%), Gaps = 37/320 (11%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + ++FSP G++LA A+ + I+ + + H I+ +AWS D Sbjct: 39 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE----KTISGHKLGISDVAWSSDS 94 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 LL+++S D ++K+WD+S K LK ++ S C + + L V+ F+ES Sbjct: 95 NLLVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES------ 147 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT 204 + K L + P H + + ++I+ + G + Sbjct: 148 ------VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG---LCRIWDTASG 198 Query: 205 ECIHSLKITSS-NIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 +C+ +L + + + S NG+ + D T++ ++ S + ++ HK + Sbjct: 199 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS---KGKCLKTYTGHKNEKY 255 Query: 264 INKLQWNCIL--FSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWD 321 CI FS +++V+ GS + +YIW + +V+ L+G + +I Sbjct: 256 -------CIFANFSVTGGKWIVS---GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 305 Query: 322 FYSMSIVSNGFE-SGNVYVW 340 I S E + +W Sbjct: 306 PTENIIASAALENDKTIKLW 325 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 49/278 (17%), Positives = 107/278 (38%), Gaps = 31/278 (11%) Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 L H + ++S+ +SP+G L +SS D IK+W I W Sbjct: 35 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 94 Query: 127 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 186 ++ S+D + S K L + H + C N+I+ Sbjct: 95 N-------------LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 141 Query: 187 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISID 246 G+ + + + + +C+ +L S + + +++G + + D R ++ + Sbjct: 142 GS---FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS- 197 Query: 247 DENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVR 306 ++ ++ + + + FS N +Y++A+T + L +W+ + G ++ Sbjct: 198 --GQCLKTLIDD------DNPPVSFVKFSPN-GKYILAATL---DNTLKLWDYSKGKCLK 245 Query: 307 VLEGAEEE--LIDINWDFYSMSIVSNGFESGNVYVWSV 342 G + E I N+ + +G E VY+W++ Sbjct: 246 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 283 >5WLC-LO nrPDB Length = 923 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 71/370 (19%), Positives = 141/370 (38%), Gaps = 43/370 (11%) Query: 6 QDPFAVLKEHPEK-LTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI--- 61 +D A+L + + H + ++FSP G AL + D + Sbjct: 75 EDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFA 134 Query: 62 -CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP---I 117 V + H + ITS+ WS D R +LT+S+D S K+W + K L F+ + Sbjct: 135 PFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYV 194 Query: 118 WGCQWLDAKRRLCVATIFEESDAYVIDFSNDP------VASLLSKSDEKQLSS-----TP 166 G + + + + T+ ++ +V +F+ P + K +E +S T Sbjct: 195 MGAFFSHDQEK--IYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITK 252 Query: 167 DHGYV-----LVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLI 221 H + + C ++ VG + G ++ + L I L + + + + Sbjct: 253 KHFFYANQAKVKCVTFHPATRLLAVGFTSGE---FRLYDLPDFTLIQQLSMGQNPVNTVS 309 Query: 222 VSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEY 281 V+Q GE LA S + ++ + + S + + + D N L +S + + Sbjct: 310 VNQTGEWLAFGSS----KLGQLLVYEWQSESYILKQQGHFDSTNSLA-----YSPDGSRV 360 Query: 282 LVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 + AS G ++ +W+ TSG + E + + + + S+ G V W Sbjct: 361 VTASEDG----KIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSL-DGTVRAWD 415 Query: 342 VVIPPKWSAL 351 ++ + Sbjct: 416 LIRYRNFRTF 425 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 49/371 (13%), Positives = 122/371 (32%), Gaps = 74/371 (19%) Query: 29 TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 L +S ++ + + I+ +D+ + H + +S D + Sbjct: 149 ITSLTWSQDSRFILTTSKDLSAKIWSVDS-EEKNLAATTFNGHRDYVMGAFFSHDQEKIY 207 Query: 89 TSSRDWSIKLW-----------------------DLSKPSKPLKEIRF----DSPIWGCQ 121 T S+D ++ +W D+SK S + + F + + Sbjct: 208 TVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVT 267 Query: 122 WLDAKRRLCVATIFEESDAY-----------------VIDFSNDPVASLLSK-------- 156 + A R L V E Y V S + L+ Sbjct: 268 FHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQL 327 Query: 157 -----SDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLK 211 E + H ++ + ++ + G + K + C+ + + Sbjct: 328 LVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKI---KVWDITSGFCLATFE 384 Query: 212 ITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNC 271 +S++ + ++ G+ + + D T+R +++ ++Q+NC Sbjct: 385 EHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRT---------FTGTERIQFNC 435 Query: 272 ILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNG 331 + + E + A + + +++W +G L+ L G E + +++ + + S Sbjct: 436 LAVDP-SGEVVCAGSLDNFD--IHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASAS 492 Query: 332 FESGNVYVWSV 342 ++ + +WS+ Sbjct: 493 WDK-TIRIWSI 502 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 82/216 (37%), Gaps = 18/216 (8%) Query: 28 RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 87 T L +SP G + +G + ++D+ + + H +T++ ++ G+++ Sbjct: 347 STNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLA----TFEEHTSSVTAVQFAKRGQVM 402 Query: 88 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSN 147 +SS D +++ WDL + + + C +D + A + D +V Sbjct: 403 FSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHV----- 457 Query: 148 DPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECI 207 S + L + H + C ++ +++ + W + S++ Sbjct: 458 ------WSVQTGQLLDALSGHEGPVSCLSFSQENSVLASAS---WDKTIRIWSIFGRSQQ 508 Query: 208 HSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 S++ L + +G+ +A++ I + I Sbjct: 509 VEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNI 544 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 37/272 (13%), Positives = 99/272 (36%), Gaps = 18/272 (6%) Query: 30 ECLQFSPCGDYLALGCANG-ALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 CL P G+ + G + + ++ + T + + + L H P++ +++S + +L Sbjct: 434 NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLL----DALSGHEGPVSCLSFSQENSVLA 489 Query: 89 TSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID---- 144 ++S D +I++W + S+ ++ I S + + + V+T+ + + I+ Sbjct: 490 SASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQ 549 Query: 145 -FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 + D ++S + + + T + + + + G + + + Sbjct: 550 VGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAI-VAGGNNNSICLYDVPN 608 Query: 204 TECIHSLKITSSNI--KHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQ 261 + ++ + L + + D E S ++ L + Sbjct: 609 EVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGG 668 Query: 262 DVINK-----LQWNCILFSNNTAEYLVASTHG 288 D+ + ++ + FS + AST G Sbjct: 669 DLSTRKMRPEVRVTSVQFSPTANAFAAASTEG 700 Score = 47.9 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 25/234 (10%), Positives = 64/234 (27%), Gaps = 27/234 (11%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + CL FS LA + + I+ + P + + +++ PDG Sbjct: 472 HEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYS----DVLALSMRPDG 527 Query: 85 RLLLTSSRDWSIKLWDLSKPS--------KPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 + + S+ I ++++ K + RF+ + + + + + + Sbjct: 528 KEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSE-RSKFFTTIHYS 586 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV--CTVHTKHPNIIIVGTSKGWLD 194 ++ N+ L +E L + + + G+ D Sbjct: 587 FDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLIDD 646 Query: 195 F---YKFHSLYQTECIHSLKITSSN---------IKHLIVSQNGERLAINCSDR 236 S + + + + S A ++ Sbjct: 647 AGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEG 700 >5I2T-A nrPDB Length = 742 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 71/370 (19%), Positives = 141/370 (38%), Gaps = 43/370 (11%) Query: 6 QDPFAVLKEHPEK-LTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI--- 61 +D A+L + + H + ++FSP G AL + D + Sbjct: 100 EDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFA 159 Query: 62 -CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP---I 117 V + H + ITS+ WS D R +LT+S+D S K+W + K L F+ + Sbjct: 160 PFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYV 219 Query: 118 WGCQWLDAKRRLCVATIFEESDAYVIDFSNDP------VASLLSKSDEKQLSS-----TP 166 G + + + + T+ ++ +V +F+ P + K +E +S T Sbjct: 220 MGAFFSHDQEK--IYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITK 277 Query: 167 DHGYV-----LVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLI 221 H + + C ++ VG + G ++ + L I L + + + + Sbjct: 278 KHFFYANQAKVKCVTFHPATRLLAVGFTSGE---FRLYDLPDFTLIQQLSMGQNPVNTVS 334 Query: 222 VSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEY 281 V+Q GE LA S + ++ + + S + + + D N L +S + + Sbjct: 335 VNQTGEWLAFGSS----KLGQLLVYEWQSESYILKQQGHFDSTNSLA-----YSPDGSRV 385 Query: 282 LVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 + AS G ++ +W+ TSG + E + + + + S+ G V W Sbjct: 386 VTASEDG----KIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSL-DGTVRAWD 440 Query: 342 VVIPPKWSAL 351 ++ + Sbjct: 441 LIRYRNFRTF 450 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 49/371 (13%), Positives = 122/371 (32%), Gaps = 74/371 (19%) Query: 29 TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 L +S ++ + + I+ +D+ + H + +S D + Sbjct: 174 ITSLTWSQDSRFILTTSKDLSAKIWSVDS-EEKNLAATTFNGHRDYVMGAFFSHDQEKIY 232 Query: 89 TSSRDWSIKLW-----------------------DLSKPSKPLKEIRF----DSPIWGCQ 121 T S+D ++ +W D+SK S + + F + + Sbjct: 233 TVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVT 292 Query: 122 WLDAKRRLCVATIFEESDAY-----------------VIDFSNDPVASLLSK-------- 156 + A R L V E Y V S + L+ Sbjct: 293 FHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQL 352 Query: 157 -----SDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLK 211 E + H ++ + ++ + G + K + C+ + + Sbjct: 353 LVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKI---KVWDITSGFCLATFE 409 Query: 212 ITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNC 271 +S++ + ++ G+ + + D T+R +++ ++Q+NC Sbjct: 410 EHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRT---------FTGTERIQFNC 460 Query: 272 ILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNG 331 + + E + A + + +++W +G L+ L G E + +++ + + S Sbjct: 461 LAVDP-SGEVVCAGSLDNFD--IHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASAS 517 Query: 332 FESGNVYVWSV 342 ++ + +WS+ Sbjct: 518 WDK-TIRIWSI 527 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 82/216 (37%), Gaps = 18/216 (8%) Query: 28 RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 87 T L +SP G + +G + ++D+ + + H +T++ ++ G+++ Sbjct: 372 STNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLA----TFEEHTSSVTAVQFAKRGQVM 427 Query: 88 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSN 147 +SS D +++ WDL + + + C +D + A + D +V Sbjct: 428 FSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHV----- 482 Query: 148 DPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECI 207 S + L + H + C ++ +++ + W + S++ Sbjct: 483 ------WSVQTGQLLDALSGHEGPVSCLSFSQENSVLASAS---WDKTIRIWSIFGRSQQ 533 Query: 208 HSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 S++ L + +G+ +A++ I + I Sbjct: 534 VEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNI 569 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 37/272 (13%), Positives = 99/272 (36%), Gaps = 18/272 (6%) Query: 30 ECLQFSPCGDYLALGCANG-ALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 CL P G+ + G + + ++ + T + + + L H P++ +++S + +L Sbjct: 459 NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLL----DALSGHEGPVSCLSFSQENSVLA 514 Query: 89 TSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID---- 144 ++S D +I++W + S+ ++ I S + + + V+T+ + + I+ Sbjct: 515 SASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQ 574 Query: 145 -FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 + D ++S + + + T + + + + G + + + Sbjct: 575 VGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAI-VAGGNNNSICLYDVPN 633 Query: 204 TECIHSLKITSSNI--KHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQ 261 + ++ + L + + D E S ++ L + Sbjct: 634 EVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGG 693 Query: 262 DVINK-----LQWNCILFSNNTAEYLVASTHG 288 D+ + ++ + FS + AST G Sbjct: 694 DLSTRKMRPEVRVTSVQFSPTANAFAAASTEG 725 Score = 47.9 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 25/234 (10%), Positives = 64/234 (27%), Gaps = 27/234 (11%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + CL FS LA + + I+ + P + + +++ PDG Sbjct: 497 HEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYS----DVLALSMRPDG 552 Query: 85 RLLLTSSRDWSIKLWDLSKPS--------KPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 + + S+ I ++++ K + RF+ + + + + + + Sbjct: 553 KEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSE-RSKFFTTIHYS 611 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV--CTVHTKHPNIIIVGTSKGWLD 194 ++ N+ L +E L + + + G+ D Sbjct: 612 FDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLIDD 671 Query: 195 F---YKFHSLYQTECIHSLKITSSN---------IKHLIVSQNGERLAINCSDR 236 S + + + + S A ++ Sbjct: 672 AGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEG 725 >5MZH-A nrPDB Length = 452 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 52/279 (18%), Positives = 99/279 (35%), Gaps = 34/279 (12%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + CL F+P +A G + ++D++T + L H I S+ ++ G Sbjct: 178 HQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERA----TLAGHRAEIVSLGFNTGG 233 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 L++T S D +LWD+ L R +T F + V+ Sbjct: 234 DLIVTGSFDHDSRLWDVRTGQC-------------VHVLSGHRGEVSSTQFNYAGTLVVS 280 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT 204 S D + L + LS H ++ ++ ++ G Y H+L Sbjct: 281 GSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLY--HTLTGV 338 Query: 205 ECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVI 264 C H+L I + + G RL SD+T R ++ D +++ H + Sbjct: 339 -CQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWD---CDTGECLQVLEGHTDEIFS 394 Query: 265 NKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGT 303 + ++++ GS + IW+ + + Sbjct: 395 CAFNYE--------GDFIIT---GSKDNTCRIWKALTAS 422 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 48/323 (14%), Positives = 105/323 (32%), Gaps = 37/323 (11%) Query: 22 TIENPLRT-ECLQFS-PCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIA 79 T+E + F+ P GD + G + ++D T + L H I ++ Sbjct: 131 TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQ----LYYTLKGHQTEIVCLS 186 Query: 80 WSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESD 139 ++P ++ T S D + KLWD+ + + I F Sbjct: 187 FNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSL-------------GFNTGG 233 Query: 140 AYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFH 199 ++ S D + L + + H + T +++ G+ + Sbjct: 234 DLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTS---RLW 290 Query: 200 SLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHK 259 + C+ + + + + G ++ +D + R Y + H+ Sbjct: 291 DVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLT---GVCQHTLVGHE 347 Query: 260 YQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDIN 319 + + F+ + A SS +W+ +G ++VLEG +E+ Sbjct: 348 GEIS-------KVAFNPQGTRLITA----SSDKTCRLWDCDTGECLQVLEGHTDEIFSCA 396 Query: 320 WDFYSMSIVSNGFESGNVYVWSV 342 ++ Y + G + +W Sbjct: 397 FN-YEGDFIITGSKDNTCRIWKA 418 Score = 157 bits (397), Expect = 8e-39, Method: Composition-based stats. Identities = 50/287 (17%), Positives = 101/287 (35%), Gaps = 32/287 (11%) Query: 55 MDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFD 114 ++ +L AH+ P+T+ A++ G +T S D + K+W+ + Sbjct: 77 LEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEE-------- 128 Query: 115 SPIWGCQWLDAKRRLCVATIFEES-DAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV 173 L+ + + A F ++ S D L + + H +V Sbjct: 129 -----VFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIV 183 Query: 174 CTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINC 233 C II G+ + K + + +L + I L + G+ + Sbjct: 184 CLSFNPQSTIIATGSMD---NTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGS 240 Query: 234 SDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHE 293 D R +++ V + H+ + + + A LV S GS Sbjct: 241 FDHDSRLWDVRT---GQCVHVLSGHRGEVSSTQFNY---------AGTLVVS--GSIDCT 286 Query: 294 LYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 +W+ SG + V +G +E++D+ +D +VS G+ ++ Sbjct: 287 SRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSAS-ADGSARLY 332 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 77/210 (36%), Gaps = 19/210 (9%) Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHT-KHPNIIIVGTSKGW 192 F +S I S D + + +++ + H V+ + + I+ G+ + Sbjct: 101 AFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGS---F 157 Query: 193 LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAV 252 K Y + ++LK + I L + +A D T + +++ + Sbjct: 158 DKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDV---ETGQER 214 Query: 253 ELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAE 312 H+ + V N + +V GS H+ +W+ +G V VL G Sbjct: 215 ATLAGHRAEIVSLGF--------NTGGDLIVT---GSFDHDSRLWDVRTGQCVHVLSGHR 263 Query: 313 EELIDINWDFYSMSIVSNGFESGNVYVWSV 342 E+ ++ Y+ ++V +G +W V Sbjct: 264 GEVSSTQFN-YAGTLVVSGSIDCTSRLWDV 292 Score = 71.4 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 38/82 (46%), Gaps = 5/82 (6%) Query: 19 LTHTI-ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 HT+ + + F+P G L ++ ++D DT + +L H I S Sbjct: 339 CQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECL----QVLEGHTDEIFS 394 Query: 78 IAWSPDGRLLLTSSRDWSIKLW 99 A++ +G ++T S+D + ++W Sbjct: 395 CAFNYEGDFIITGSKDNTCRIW 416 >5FVM-C nrPDB Length = 303 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 135/307 (43%), Gaps = 33/307 (10%) Query: 19 LTHTIENP-LRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 + TI++ + L+ + YLA + +YD+ + P P + H +TS Sbjct: 24 CSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLYDIRSNNP--NPVSSFEGHKGNVTS 80 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 IA+ + R +++SS D +IK+WD+ PS + + ++P+ + L + ++ Sbjct: 81 IAFQQENRWMVSSSEDGTIKVWDVRSPSVQ-RNYKHNAPVNEVAIHPNQGELI--SCDQD 137 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 + + D + + L+ D L S ++++ G +KG ++ Sbjct: 138 GNIRIWDLGENQCTNQLTPEDNTPLQSLSV----------ASDGSMLVAGNNKGNCYVWR 187 Query: 198 F--HSLYQT-ECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 H+ T E + K + I +++S + + LA +D T R + I ++N +E Sbjct: 188 MPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNI---EDNYQLET 244 Query: 255 TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEE 314 TL D + W+C FS ++A YLV + S H + +W+ ++ +VR G + Sbjct: 245 TL-----DGHQRWVWDCA-FSADSA-YLVTAC---SDHYVRLWDLSTSEIVRQYGGHHKG 294 Query: 315 LIDINWD 321 + + + Sbjct: 295 AVCVALN 301 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 34/174 (19%), Positives = 61/174 (35%), Gaps = 26/174 (14%) Query: 229 LAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHG 288 LA D TIR +E + ++ +N+L+ + +YL A+ H Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADSQ-----VNRLE------ITSDKKYLAAAGHL 53 Query: 289 SSAHELYIWETTSGTL--VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPP 346 + +++ S V EG + + I + + + + E G + VW V P Sbjct: 54 ----HVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQQEN-RWMVSSSEDGTIKVWDVRSPS 108 Query: 347 ---KWSALAPDFEEVEENVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTRE 397 + AP V E V + E D+ + + E + T E Sbjct: 109 VQRNYKHNAP----VNE-VAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPE 157 >6EMK-B nrPDB Length = 303 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 130/307 (42%), Gaps = 33/307 (10%) Query: 19 LTHTIENP-LRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 + TI++ + L+ + LA + +YD+ T P P H +TS Sbjct: 24 CSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTTNP--NPVASFEGHRGNVTS 80 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 +++ D R ++TSS D +IK+WD+ PS P + + ++P+ + L + + Sbjct: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSIP-RNYKHNAPVNEVVIHPNQGELI--SCDRD 137 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 + + D + L+ D+ L S +++ +KG ++ Sbjct: 138 GNIRIWDLGENQCTHQLTPEDDTSLQSLS----------MASDGSMLAAANTKGNCYVWE 187 Query: 198 F---HSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 + + + S+ I +++S + + LA +D T R + I D++ +E Sbjct: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI---DDDFKLET 244 Query: 255 TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEE 314 TL D + W+C FS ++A YLV + SS H + +W+ ++ +VR G + Sbjct: 245 TL-----DGHQRWVWDCA-FSADSA-YLVTA---SSDHYVRLWDLSTREIVRQYGGHHKG 294 Query: 315 LIDINWD 321 + + + Sbjct: 295 AVCVALN 301 Score = 47.9 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 36/191 (18%), Positives = 66/191 (34%), Gaps = 28/191 (14%) Query: 229 LAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHG 288 L D TIR +E + ++ + +N+L+ T + + +T G Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQ-----VNRLE--------ITNDKKLLATAG 51 Query: 289 SSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV---VIP 345 LY TT+ V EG + +++ + E G + VW V IP Sbjct: 52 HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSIP 110 Query: 346 PKWSALAPDFEEVEENVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNN 405 + AP V E V + + E D + + E T E ++ Sbjct: 111 RNYKHNAP----VNEVVIH-PNQGELISCDRDGNIRIWDLGENQCTHQLTPE------DD 159 Query: 406 LLVERFTIPTD 416 ++ ++ +D Sbjct: 160 TSLQSLSMASD 170 >6F3T-A nrPDB Length = 608 Score = 167 bits (423), Expect = 7e-42, Method: Composition-based stats. Identities = 52/290 (17%), Positives = 99/290 (34%), Gaps = 57/290 (19%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPG---------------------------NMLG 69 +A G A+ + ++ + + V +L Sbjct: 289 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 348 Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRL 129 H P+ ++SPD LL+SS D +++LW L + + + P+W Sbjct: 349 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD---------- 398 Query: 130 CVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTS 189 T F Y + +D VA L + + L H + CT + N + G++ Sbjct: 399 ---TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 455 Query: 190 KGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDEN 249 + + + C+ I L S NG LA +D + ++I Sbjct: 456 DRTV---RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMV 512 Query: 250 SAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 299 ++ + D + L FS + ++AS GS + + +W+ Sbjct: 513 GELK-----GHTDTVCSL-----RFSRDGE--ILAS--GSMDNTVRLWDA 548 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 36/225 (16%), Positives = 71/225 (31%), Gaps = 20/225 (8%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + FSP +YL +G + ++ + TF + H P+ +SP G Sbjct: 350 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG----YKGHNYPVWDTQFSPYG 405 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 ++ D +LW + + ++ YV Sbjct: 406 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN-------------YVAT 452 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT 204 S D L + + H + + + + G + G + + Sbjct: 453 GSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL---WDIGHG 509 Query: 205 ECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDEN 249 + LK + + L S++GE LA D T+R ++ E+ Sbjct: 510 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFED 554 Score = 104 bits (258), Expect = 9e-23, Method: Composition-based stats. Identities = 41/268 (15%), Positives = 92/268 (34%), Gaps = 42/268 (15%) Query: 75 ITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATI 134 +T++ + D L+ D ++++W ++ K L+ ++ S + Sbjct: 281 LTAVDVTDDSSLIAGGFADSTVRVWSVT--PKKLRSVKQASDLSLID------------- 325 Query: 135 FEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLD 194 S+D + ++ + +L H + + N ++ + G + Sbjct: 326 ---------KESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTV- 375 Query: 195 FYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 + SL C+ K + + S G DR R + D + + Sbjct: 376 --RLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW---ATDHYQPLRI 430 Query: 255 TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEE 314 H NC F N+ Y+ GS+ + +W+ +G VR+ G + Sbjct: 431 FAGHLADV-------NCTRFHPNSN-YVAT---GSADRTVRLWDVLNGNCVRIFTGHKGP 479 Query: 315 LIDINWDFYSMSIVSNGFESGNVYVWSV 342 + + + + ++ G G V +W + Sbjct: 480 IHSLTFSP-NGRFLATGATDGRVLLWDI 506 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 28/201 (13%), Positives = 65/201 (32%), Gaps = 20/201 (9%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 QFSP G Y G + ++ D ++P+ + H+ + + P+ + T S Sbjct: 400 QFSPYGYYFVSGGHDRVARLWATDHYQPL----RIFAGHLADVNCTRFHPNSNYVATGSA 455 Query: 93 DWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 D +++LWD+ + PI + R ++ + D Sbjct: 456 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR-------------FLATGATDGRVL 502 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKI 212 L + H + ++ I+ G+ + + ++ Sbjct: 503 LWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTT 562 Query: 213 TSSNIKHLIVSQNGERLAINC 233 + +I + +N + L + Sbjct: 563 ATGHIN---LPENSQELLLGT 580 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 60/162 (37%), Gaps = 7/162 (4%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + C +F P +Y+A G A+ + ++D+ + + H PI S+ +SP+G Sbjct: 434 HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCV----RIFTGHKGPIHSLTFSPNG 489 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 R L T + D + LWD+ + + ++ +A+ ++ + D Sbjct: 490 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE--ILASGSMDNTVRLWD 547 Query: 145 FSND-PVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 + + P++ L+ + ++ Sbjct: 548 AIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVV 589 Score = 83.0 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 53/120 (44%), Gaps = 4/120 (3%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 + L FSP G +LA G +G ++++D+ + L H + S+ +S Sbjct: 474 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE----LKGHTDTVCSLRFSR 529 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 DG +L + S D +++LWD K + L+ F + + + L + T +S V Sbjct: 530 DGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVV 589 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 20/157 (12%), Positives = 50/157 (31%), Gaps = 26/157 (16%) Query: 206 CIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI----------------SIDDEN 249 C ++ + + V+ + +A +D T+R + + + + Sbjct: 270 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 329 Query: 250 SAVELTLEHKYQD-----VINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 304 +E ++ K + FS + L +S G+ + +W + T Sbjct: 330 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGT----VRLWSLQTFTC 385 Query: 305 VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 + +G + D + Y +G +W+ Sbjct: 386 LVGYKGHNYPVWDTQFSPYG-YYFVSGGHDRVARLWA 421 >6MZM-G nrPDB Length = 800 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 48/234 (20%), Positives = 88/234 (37%), Gaps = 30/234 (12%) Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 +L H P+ ++SPD LL+SS D +++LW L + + + P+W Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWD------ 590 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 T F Y + +D VA L + + L H + CT + N + Sbjct: 591 -------TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISI 245 G++ + + + C+ I L S NG LA +D + ++I Sbjct: 644 TGSADRTV---RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700 Query: 246 DDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 299 ++ + D + L FS + ++AS GS + + +W+ Sbjct: 701 GLMVGELK-----GHTDTVCSL-----RFSRDGE--ILAS--GSMDNTVRLWDA 740 Score = 144 bits (363), Expect = 7e-35, Method: Composition-based stats. Identities = 36/225 (16%), Positives = 71/225 (31%), Gaps = 20/225 (8%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + FSP +YL +G + ++ + TF + H P+ +SP G Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG----YKGHNYPVWDTQFSPYG 597 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 ++ D +LW + + ++ YV Sbjct: 598 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN-------------YVAT 644 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT 204 S D L + + H + + + + G + G + + Sbjct: 645 GSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL---WDIGHG 701 Query: 205 ECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDEN 249 + LK + + L S++GE LA D T+R ++ E+ Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFED 746 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 38/233 (16%), Positives = 80/233 (34%), Gaps = 31/233 (13%) Query: 111 IRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGY 170 P++G + + L + S D L S L H Y Sbjct: 540 YGHSGPVYGASFSPDRNYLLSS-------------SEDGTVRLWSLQTFTCLVGYKGHNY 586 Query: 171 VLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLA 230 + T + + + G G + + + + +++ N +A Sbjct: 587 PVWDTQFSPYGYYFVSG---GHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643 Query: 231 INCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSS 290 +DRT+R +++ + V + HK I+ L FS N +L G++ Sbjct: 644 TGSADRTVRLWDVL---NGNCVRIFTGHK--GPIHSLT-----FSPN-GRFLAT---GAT 689 Query: 291 AHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 343 + +W+ G +V L+G + + + + I+++G V +W + Sbjct: 690 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFS-RDGEILASGSMDNTVRLWDAI 741 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 28/201 (13%), Positives = 65/201 (32%), Gaps = 20/201 (9%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 QFSP G Y G + ++ D ++P+ + H+ + + P+ + T S Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPL----RIFAGHLADVNCTRFHPNSNYVATGSA 647 Query: 93 DWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 D +++LWD+ + PI + R ++ + D Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR-------------FLATGATDGRVL 694 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKI 212 L + H + ++ I+ G+ + + ++ Sbjct: 695 LWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTT 754 Query: 213 TSSNIKHLIVSQNGERLAINC 233 + +I + +N + L + Sbjct: 755 ATGHIN---LPENSQELLLGT 772 Score = 101 bits (250), Expect = 8e-22, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 60/162 (37%), Gaps = 7/162 (4%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + C +F P +Y+A G A+ + ++D+ + + H PI S+ +SP+G Sbjct: 626 HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCV----RIFTGHKGPIHSLTFSPNG 681 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 R L T + D + LWD+ + + ++ +A+ ++ + D Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE--ILASGSMDNTVRLWD 739 Query: 145 FSND-PVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 + + P++ L+ + ++ Sbjct: 740 AIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVV 781 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 53/120 (44%), Gaps = 4/120 (3%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 + L FSP G +LA G +G ++++D+ + L H + S+ +S Sbjct: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE----LKGHTDTVCSLRFSR 721 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 DG +L + S D +++LWD K + L+ F + + + L + T +S V Sbjct: 722 DGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVV 781 >5FL8-q nrPDB Length = 515 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 66/417 (15%), Positives = 128/417 (30%), Gaps = 100/417 (23%) Query: 4 LLQDPFAVLKEHP-EKLTHTIENPLRT-ECLQFSP-CGDYLALGCANGALVIYDMDTFRP 60 LL P AV K P + + I T C F+P + G + I+D DT P Sbjct: 119 LLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTP 178 Query: 61 ICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWG- 119 + + L H + ++WSPDG ++ T S D +I+LWD +R S Sbjct: 179 M----HTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITS 234 Query: 120 -----CQWLDAKRRLCVATIFEESDAYVID------------------------------ 144 + + +A+ ++ + D Sbjct: 235 LSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYS 294 Query: 145 FSNDPVASLLSK-SDEKQLSSTPDHG---------------------------------- 169 S+D + S + ++ H Sbjct: 295 GSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQK 354 Query: 170 -----YVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ 224 Y +C + +++ + + + L T+ I + + H+ S Sbjct: 355 KALENYEKICKKNGNSEEMMVTASDDYTMFLWNP--LKSTKPIARMTGHQKLVNHVAFSP 412 Query: 225 NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVA 284 +G + D +I+ ++ + + H +C L+ Sbjct: 413 DGRYIVSASFDNSIKLWD---GRDGKFISTFRGHVASVYQVAWSSDC---------RLLV 460 Query: 285 STHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 S S L +W+ + L L G ++E+ ++W V +G + V +W+ Sbjct: 461 SC--SKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKR-VCSGGKDKMVRLWT 514 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 61/148 (41%), Gaps = 10/148 (6%) Query: 1 MNILLQDPFAVLKEHPEKLTHTIE----NPLRTECLQFSPCGDYLALGCANGALVIYDMD 56 M + D + + +P K T I + + FSP G Y+ + ++ ++D Sbjct: 373 MMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGR 432 Query: 57 TFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP 116 + I + HV + +AWS D RLL++ S+D ++K+WD+ + Sbjct: 433 DGKFI----STFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDE 488 Query: 117 IWGCQWLDAKRRLCVATIFEESDAYVID 144 ++ W +R+C ++ + Sbjct: 489 VYTVDWSVDGKRVCSGG--KDKMVRLWT 514 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 36/257 (14%), Positives = 82/257 (31%), Gaps = 31/257 (12%) Query: 95 SIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLL 154 SIK L +R I Q + +L + + + + Sbjct: 33 SIKFQALDTGDNVGGALRVPGAISEKQLEELLNQLNGTSDDPVPYTFSCTIQGKKASDPV 92 Query: 155 SKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITS 214 K + T + L+ + + I + + + K T ++ Sbjct: 93 -----KTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVK----PVTRSSSAIAGHG 143 Query: 215 SNIKHLIVSQ-NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCIL 273 S I + R+ D T R ++ D + + H W + Sbjct: 144 STILCSAFAPHTSSRMVTGAGDNTARIWD---CDTQTPMHTLKGH--------YNW-VLC 191 Query: 274 FSNNTAEYLVASTHGSSAHELYIWETTSGTLVR-VLEGAEEELIDINWDF-YSMSI---- 327 S + ++A+ GS + + +W+ SG + L G + + ++W+ + + Sbjct: 192 VSWSPDGEVIAT--GSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKP 249 Query: 328 -VSNGFESGNVYVWSVV 343 +++ + G + +W V Sbjct: 250 RLASSSKDGTIKIWDTV 266 >6HQA-B nrPDB Length = 722 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 56/320 (17%), Positives = 102/320 (31%), Gaps = 53/320 (16%) Query: 4 LLQDPFAVLKEH------PEKLTHTIENPLR-TECLQFSPCGDYLALGCANGALVIYDMD 56 ++QD A +K P +T N CL+F+ +A G + + ++ +D Sbjct: 361 MIQDSRAKIKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSID 420 Query: 57 T-----------------FRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 L H + + +SPD R L++ S D +++LW Sbjct: 421 GSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLW 480 Query: 100 DLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDE 159 L + + S +W ++ Y S+D A L S Sbjct: 481 SLDTYTCLVSYKGHSSSVWDVKFSPMGH-------------YFATASHDQTARLWSCDHI 527 Query: 160 KQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKH 219 L H + C + + G+S + + + EC+ S I Sbjct: 528 YPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTA---RMWDIARGECVRVFMGHSGAINC 584 Query: 220 LIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTA 279 L VS +G LA D + ++IS ++ H + + FS Sbjct: 585 LAVSPDGRWLASAGEDSVVCLWDIST---GRRIKAMRGHG------RSSIYSLAFSREGT 635 Query: 280 EYLVASTHGSSAHELYIWET 299 + S + +W+ Sbjct: 636 VLVSTGADNS----VRVWDV 651 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 46/293 (15%), Positives = 97/293 (33%), Gaps = 31/293 (10%) Query: 73 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW---------- 122 +T + ++ D ++ + +D IKLW + PL+ + + P Sbjct: 391 NDLTCLKFNDDSTMVASGFQDSFIKLWSI--DGSPLRSLLKNDPYNQQNNDGVAVKGSRR 448 Query: 123 LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN 182 L F + Y+I S D L S L S H + + + Sbjct: 449 LVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGH 508 Query: 183 IIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 + + +Y + +++ + N L SD+T R ++ Sbjct: 509 YFATASHDQTARLWSCDHIY---PLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWD 565 Query: 243 ISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSG 302 I+ V + + H NC+ S + +L ++ + +W+ ++G Sbjct: 566 IA---RGECVRVFMGH-------SGAINCLAVSPD-GRWLASA---GEDSVVCLWDISTG 611 Query: 303 TLVRVLEGA-EEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPD 354 ++ + G + + + +VS G +V VW V + P+ Sbjct: 612 RRIKAMRGHGRSSIYSLAFSREGTVLVSTG-ADNSVRVWDVKKNTNSPSAQPE 663 Score = 74.5 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 23/86 (26%), Positives = 44/86 (51%), Gaps = 5/86 (5%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH-VRPITSIAWS 81 + + CL SP G +LA + + ++D+ T R I + H I S+A+S Sbjct: 576 MGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRI----KAMRGHGRSSIYSLAFS 631 Query: 82 PDGRLLLTSSRDWSIKLWDLSKPSKP 107 +G +L+++ D S+++WD+ K + Sbjct: 632 REGTVLVSTGADNSVRVWDVKKNTNS 657 Score = 61.8 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 24/191 (12%), Positives = 64/191 (33%), Gaps = 16/191 (8%) Query: 180 HPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIR 239 +I ++ S+ + + + C+++ T++++ L + + +A D I+ Sbjct: 356 RNDIAMIQDSRAKIKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIK 415 Query: 240 QYEISIDDENSAVEL-TLEHKYQDVI----------NKLQWNCILFSNNTAEYLVASTHG 288 + I S ++ + D + + + FS + YL++ Sbjct: 416 LWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPD-NRYLISC--- 471 Query: 289 SSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKW 348 S + +W + T + +G + D+ + + +WS Sbjct: 472 SEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMG-HYFATASHDQTARLWSCDHIYPL 530 Query: 349 SALAPDFEEVE 359 A +V+ Sbjct: 531 RIFAGHLNDVD 541 >1VYH-C nrPDB Length = 410 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 47/354 (13%), Positives = 107/354 (30%), Gaps = 56/354 (15%) Query: 7 DPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGN 66 DP + PEK + + + F P + + + ++D +T Sbjct: 90 DPKEWIPRPPEKYALS-GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE----R 144 Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 L H + I++ G+LL + S D +IKLWD D + + Sbjct: 145 TLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNG 204 Query: 127 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 186 ++ S D + + + H + + +I Sbjct: 205 DH-------------IVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIAS 251 Query: 187 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQN--------------------G 226 ++ + + + EC L+ ++ + + G Sbjct: 252 CSNDQTV---RVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPG 308 Query: 227 ERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVAST 286 L D+TI+ +++S + + H + + S +++++ Sbjct: 309 PFLLSGSRDKTIKMWDVST---GMCLMTLVGH------DNWVRGVLFHS--GGKFILSCA 357 Query: 287 HGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 L +W+ + ++ L E + +++ + V G V VW Sbjct: 358 D---DKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHK-TAPYVVTGSVDQTVKVW 407 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 25/225 (11%), Positives = 70/225 (31%), Gaps = 14/225 (6%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + + P GD++ + + ++++ T + H + + + DG Sbjct: 191 HDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCV----KTFTGHREWVRMVRPNQDG 246 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATI-------FEE 137 L+ + S D ++++W ++ + + W ++ + Sbjct: 247 TLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGK 306 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 +++ S D + S L + H + + I+ S + Sbjct: 307 PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFIL---SCADDKTLR 363 Query: 198 FHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 C+ +L + L + + D+T++ +E Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 11/53 (20%), Positives = 27/53 (50%), Gaps = 1/53 (1%) Query: 289 SSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 S + +W+ +G R L+G + + DI++D +S ++++ + +W Sbjct: 127 SEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSGKLLASCSADMTIKLWD 178 Score = 28.7 bits (62), Expect = 4.7, Method: Composition-based stats. Identities = 5/40 (12%), Positives = 14/40 (35%), Gaps = 1/40 (2%) Query: 18 KLTHTI-ENPLRTECLQFSPCGDYLALGCANGALVIYDMD 56 + T+ + L F Y+ G + + +++ Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 >6Q8F-A nrPDB Length = 514 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 62/341 (18%), Positives = 123/341 (36%), Gaps = 41/341 (12%) Query: 13 KEHPEKLTHTIENP--LRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICV----PGN 66 ++ P +L+ I+ EC +FSP G YL G +G + +++ T + + Sbjct: 200 EKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 259 Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 + + +S D +L T ++D IK+W + + + A Sbjct: 260 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRR------------FERAH 307 Query: 127 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 186 + F + + ++ S D + K L H + T+ + II Sbjct: 308 SKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIIS 367 Query: 187 GTSKGWLDFYKFHSLYQTECIHSLK------ITSSNIKHLIVSQ-NGERLAINCSDRTIR 239 +S G + K ++ TEC ++ K T + +I+ N E + T+ Sbjct: 368 ASSDGTV---KIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVV 424 Query: 240 QYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 299 + + V K + + C S E++ LY + T Sbjct: 425 IMNM----QGQIVRSFSSGKREGG----DFVCCALSP-RGEWIYCV---GEDFVLYCFST 472 Query: 300 TSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 +G L R L E+++I I + ++++ E G + +W Sbjct: 473 VTGKLERTLTVHEKDVIGIAHHPH-QNLIATYSEDGLLKLW 512 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 29/212 (13%), Positives = 60/212 (28%), Gaps = 42/212 (19%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 + CL FS + + + I+ + + + + H + ++ D Sbjct: 306 AHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTL----KEFRGHSSFVNEATFTQD 361 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPL------KEIRFDSPIWGCQWLDAKRRLCV------ 131 G ++++S D ++K+W++ D + L V Sbjct: 362 GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSN 421 Query: 132 ---------------ATIFEESDAYVID-----------FSNDPVASLLSKSDEKQLSST 165 ++ E +V D V S K + Sbjct: 422 TVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTL 481 Query: 166 PDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 H ++ H H N+I + G L +K Sbjct: 482 TVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 513 >3JB9-g nrPDB Length = 558 Score = 136 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 45/319 (14%), Positives = 105/319 (32%), Gaps = 27/319 (8%) Query: 25 NPLRTECLQFSP-CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 + CL+F P G L G + + I+++ R + H RPI +++S D Sbjct: 265 HTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLL---RTFQGHARPIRDLSFSQD 321 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 143 GR L++S D +IKLWD C D + + + Sbjct: 322 GRSFLSTSFDKTIKLWDTELGKCL-----------NCFNSDRLTNCVKFQVDPDKPNEFL 370 Query: 144 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 + D + + H + ++ + + + F+++ + Sbjct: 371 AGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVP 430 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 + + + + S + + NG+ +A D I Y + ++ + Sbjct: 431 IKFVADIAMHSMP--RVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGY 488 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFY 323 + + FS + + G++ W+ + L+ L + + + Sbjct: 489 SLE-----VGFSPDGRFVFSGDSSGNAC----FWDWKTCKLMAKLPAHSGPVQSMAFHPQ 539 Query: 324 -SMSIVSNGFESGNVYVWS 341 + + ++ G++ W Sbjct: 540 ETSKVATSSIVDGSIKYWD 558 >6QX9-4B nrPDB Length = 522 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 51/317 (16%), Positives = 105/317 (33%), Gaps = 42/317 (13%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRL----- 86 FSP LA C +G ++ + P C + L H + +I + P + Sbjct: 237 CHFSPNSKMLATACWSGLCKLWSV----PDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPK 292 Query: 87 ---LLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 143 L + + D S+KLW L + W + R ++ Sbjct: 293 DVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGR-------------FLG 339 Query: 144 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 D L ++++ H + + ++ + G F + L Sbjct: 340 TTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSL---AGTGGLDAFGRVWDLRT 396 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 CI L+ I + S NG +A D T + +++ + V H Q++ Sbjct: 397 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR---QRRCVYTIPAH--QNL 451 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFY 323 + + F +L+ G+ + IW + ++ L G E +++ ++ Sbjct: 452 VTG-----VKFEPIHGNFLLT---GAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSD 503 Query: 324 SMSIVSNGFESGNVYVW 340 I + ++ +W Sbjct: 504 GQLIATCSYDR-TFKLW 519 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 36/282 (12%), Positives = 88/282 (31%), Gaps = 25/282 (8%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRL 129 RPI+ +SP+ ++L T+ KLW + + ++ + + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPK---- 284 Query: 130 CVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTS 189 + D + + D L S ++ ++ H + + + + Sbjct: 285 -STVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFL---GT 340 Query: 190 KGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDEN 249 + ++ L E I + S + + Q+G D R +++ Sbjct: 341 TCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT---G 397 Query: 250 SAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLE 309 + H + + + Y +A+ GS + +W+ V + Sbjct: 398 RCIMFLEGHLKEIY---------GINFSPNGYHIAT--GSGDNTCKVWDLRQRRCVYTIP 446 Query: 310 GAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSAL 351 + + + ++ + + G +W+ P WS L Sbjct: 447 AHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTH---PGWSPL 485 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 42/263 (15%), Positives = 88/263 (33%), Gaps = 46/263 (17%) Query: 18 KLTHTIE-NPLRTECLQFSPCGDY--------LALGCANGALVIYDMDTFRPICVPGNML 68 L HT+ + + F P LA A+G++ ++ +D+ P+ + Sbjct: 264 NLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVA----DI 319 Query: 69 GAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWL----- 123 H + + W P GR L T+ D S +LWDL + L + ++ + Sbjct: 320 EGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSL 379 Query: 124 ------------------------DAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDE 159 + + F + ++ S D + Sbjct: 380 AGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQR 439 Query: 160 KQLSSTPDHGYVLVCTVHTK-HPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIK 218 + + + P H ++ H N ++ G + + K + + +L + Sbjct: 440 RCVYTIPAHQNLVTGVKFEPIHGNFLLTGA---YDNTAKIWTHPGWSPLKTLAGHEGKVM 496 Query: 219 HLIVSQNGERLAINCSDRTIRQY 241 L +S +G+ +A DRT + + Sbjct: 497 GLDISSDGQLIATCSYDRTFKLW 519 Score = 91.5 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 82/253 (32%), Gaps = 39/253 (15%) Query: 100 DLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDE 159 L + +I D PI C + + L A L S D Sbjct: 217 SLRSLNNFCSQIGDDRPISYCHFSPNSKMLATAC---------WSGL----CKLWSVPDC 263 Query: 160 KQLSSTPDHGYVLVCTVHTKHPNI--------IIVGTSKGWLDFYKFHSLYQTECIHSLK 211 L + H + V + + + G + K SL E + ++ Sbjct: 264 NLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSV---KLWSLDSDEPVADIE 320 Query: 212 ITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNC 271 + + ++ +G L C DR+ R +++ + E +Q+ + ++ Sbjct: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE---------EILHQEGHSMGVYD- 370 Query: 272 ILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNG 331 I F + + + G +W+ +G + LEG +E+ IN+ ++ G Sbjct: 371 IAFHQDGS----LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH-IATG 425 Query: 332 FESGNVYVWSVVI 344 VW + Sbjct: 426 SGDNTCKVWDLRQ 438 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 29/180 (16%), Positives = 63/180 (35%), Gaps = 16/180 (8%) Query: 17 EKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 E++ H + + + F G G + ++D+ T R I L H++ I Sbjct: 356 EEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMF----LEGHLKEIY 411 Query: 77 SIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 I +SP+G + T S D + K+WDL + + + G ++ Sbjct: 412 GINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN-------- 463 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY 196 +++ + D A + + L + H ++ + +I + + Sbjct: 464 ----FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 >6BX3-A nrPDB Length = 314 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 52/304 (17%), Positives = 110/304 (36%), Gaps = 37/304 (12%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 +N L+ C + SP G +LA+ ++IYD++ V ++ +H RP + + WSP Sbjct: 9 TQNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRT---VSQTLVTSHARPFSELCWSP 64 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 DG+ + T+S D+S+++ L I +P+ ++ F + Sbjct: 65 DGQCIATASDDFSVEIIHL-SYGLLHTFIGHTAPV-------------ISLTFNRKGNLL 110 Query: 143 IDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLY 202 S D + + + + H +V + + I+ S + + Sbjct: 111 FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS--YDGLIRIFDAE 168 Query: 203 QTECIHSLKITSS--------NIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 C+ +L I + S+N L + D ++ ++ V Sbjct: 169 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWD---CIGGCVVRT 225 Query: 255 TLEHKYQDVINKLQWNC-ILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEG--- 310 + + L +C + F N G ++Y W + + +L+++L+G Sbjct: 226 FQVQPLEKGV--LHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLY 283 Query: 311 AEEE 314 Sbjct: 284 HHSS 287 Score = 89.1 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 47/278 (16%), Positives = 99/278 (35%), Gaps = 37/278 (13%) Query: 76 TSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDS-PIWGCQWLDAKRRLCVATI 134 T SPDG+ L + + +I ++D+++ + + + P W C+AT Sbjct: 16 TCAKISPDGQFLAIT-QGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG--QCIATA 72 Query: 135 FEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLD 194 ++ +I S L + H ++ + N++ + + Sbjct: 73 SDDFSVEIIHLSYGL------------LHTFIGHTAPVISLTFNRKGNLLFTSSMD---E 117 Query: 195 FYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAI-NCSDRTIRQYEISIDDENSAVE 253 K + ++ S + + V N + D IR ++ + ++ Sbjct: 118 SIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD---AETGHCLK 174 Query: 254 LTLEHKYQDVINKL-QWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLE--- 309 K N + + + FS N LV S G + IW+ G +VR + Sbjct: 175 TLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG----VVKIWDCIGGCVVRTFQVQP 230 Query: 310 ------GAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 + +N + S +V +G+E+G++Y W+ Sbjct: 231 LEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN 268 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 23/171 (13%), Positives = 56/171 (32%), Gaps = 20/171 (11%) Query: 173 VCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL-KITSSNIKHLIVSQNGERLAI 231 C + + + + + + +L + L S +G+ +A Sbjct: 16 TCAKISPDGQFLAITQG----LNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIAT 71 Query: 232 NCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSA 291 D ++ +S + + H + L S S Sbjct: 72 ASDDFSVEIIHLSYGL----LHTFIGHTAPVISLTFNRK--------GNLLFTS---SMD 116 Query: 292 HELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 + IW+T +G+L++ + E ++ ++ SI+S+G G + ++ Sbjct: 117 ESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 167 Score = 30.6 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 13/60 (21%), Positives = 25/60 (41%), Gaps = 2/60 (3%) Query: 40 YLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 + G NG + ++ DT + + L H P+ SI G ++ + + + LW Sbjct: 254 LVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF--GNIMCSLALNGDCCLW 311 >5WBU-D nrPDB Length = 328 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 46/316 (14%), Positives = 108/316 (34%), Gaps = 29/316 (9%) Query: 13 KEHPEKLTHTIENP-LRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH 71 + H T T+++ + L+ +P +A + +YD+++ P P Sbjct: 30 QAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNP--NPIISYDGV 86 Query: 72 VRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPS-KPLKEIRFDSPIWGCQWLDAKRRLC 130 + I S+ + DGR + T D + ++WDL + + + + ++PI + L Sbjct: 87 NKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELI 146 Query: 131 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSK 190 V + + P+ + + + S Sbjct: 147 V-------------GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 193 Query: 191 GWLDFYKFHSLYQTECIH-----SLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISI 245 G + E + + S + LA +D+T + + S Sbjct: 194 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 253 Query: 246 DDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLV 305 + + + + + W C FS ++ +Y+V + SS + +W +G + Sbjct: 254 FSLMTELSIKSGNPGE-SSRGWMWGCA-FSGDS-QYIVTA---SSDNLARLWCVETGEIK 307 Query: 306 RVLEGAEEELIDINWD 321 R G ++ ++ + ++ Sbjct: 308 REYGGHQKAVVCLAFN 323 Score = 64.9 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 53/158 (33%), Gaps = 9/158 (5%) Query: 27 LRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI----CVPGNMLGAHVRPITSIAWSP 82 + P Y+A + G ++++ +P + AH R +SP Sbjct: 173 VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP 232 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 D LL T S D + K+W S S + + I ++ R F Y+ Sbjct: 233 DSTLLATCSADQTCKIWRTSNFS-----LMTELSIKSGNPGESSRGWMWGCAFSGDSQYI 287 Query: 143 IDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH 180 + S+D +A L + H +VC Sbjct: 288 VTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 325 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 21/242 (8%), Positives = 52/242 (21%), Gaps = 55/242 (22%) Query: 31 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 + F G ++ G + I+D+ + C + A PI + P+ L+ Sbjct: 92 SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA---PINCVCLHPNQAELIVG 148 Query: 91 SRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPV 150 + +I +WDL + I + + + Sbjct: 149 DQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDE 208 Query: 151 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK------------- 197 + L P H + + ++ ++ ++ Sbjct: 209 VTQLIPKT-----KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 263 Query: 198 ----------------------------------FHSLYQTECIHSLKITSSNIKHLIVS 223 + E + L + Sbjct: 264 SGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 323 Query: 224 QN 225 + Sbjct: 324 DS 325 Score = 59.1 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 36/105 (34%), Gaps = 4/105 (3%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPIC----VPGNMLGAHVRPITSIA 79 + +FSP LA A+ I+ F + GN + + A Sbjct: 220 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 279 Query: 80 WSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLD 124 +S D + ++T+S D +LW + + + + D Sbjct: 280 FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFND 324 Score = 34.1 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 16/114 (14%), Positives = 39/114 (34%), Gaps = 14/114 (12%) Query: 229 LAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHG 288 LA D T+R ++ V+ +QD Q N + + + + + + G Sbjct: 17 LATAGYDHTVRFWQAHSGICTRTVQ------HQDS----QVNALEVTPDRS---MIAAAG 63 Query: 289 SSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 +Y + + + +G + + + + + G E +W + Sbjct: 64 YQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHE-DGRWMYTGGEDCTARIWDL 116 Score = 31.4 bits (69), Expect = 0.84, Method: Composition-based stats. Identities = 9/55 (16%), Positives = 22/55 (40%) Query: 291 AHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIP 345 H + W+ SG R ++ + ++ + I + G++ +Y + P Sbjct: 23 DHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNP 77 >4V8M-A7 nrPDB Length = 318 Score = 124 bits (311), Expect = 7e-29, Method: Composition-based stats. Identities = 50/316 (15%), Positives = 108/316 (34%), Gaps = 46/316 (14%) Query: 41 LALGCANGALVIYDMDTFR-----PICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWS 95 + + L+ + + R +P L H ++ +A S +G +++S D S Sbjct: 31 VVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSASWDHS 90 Query: 96 IKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLS 155 ++LW+L K + + + R+ ++ D + + Sbjct: 91 LRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQ-------------IVSGGRDNALRVWN 137 Query: 156 KSDEKQLSSTP--DHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKIT 213 + + + H + C + + ++ S GW + K L + LK Sbjct: 138 V-KGECMHTLSRGAHTDWVSCVRFSPSLDAPVI-VSGGWDNLVKVWDLATGRLVTDLKGH 195 Query: 214 SSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCIL 273 ++ + + VS +G A + D R +++ T ++ N I Sbjct: 196 TNYVTSVTVSPDGSLCASSDKDGVARLWDL-----------TKGEALSEMAAGAPINQIC 244 Query: 274 FSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL-EGAEE------ELIDINWDFYSMS 326 FS N A+ G + I++ + ++ L + E + I W + Sbjct: 245 FSPNRYWMCAATEKG-----IRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGST 299 Query: 327 IVSNGFESGNVYVWSV 342 + S G+ + VW V Sbjct: 300 LYS-GYTDNVIRVWGV 314 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 35/276 (12%), Positives = 102/276 (36%), Gaps = 26/276 (9%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + + S G++ + +L ++++ + H + + S+A+SPD Sbjct: 66 HSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQ----CQYKFLGHTKDVLSVAFSPDN 121 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 R +++ RD ++++W++ + + + + CV ++ Sbjct: 122 RQIVSGGRDNALRVWNVK--GECMHTLSRGA--------HTDWVSCVRFSPSLDAPVIVS 171 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT 204 D + + + + ++ H + + ++ G + L + Sbjct: 172 GGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDG---VARLWDLTKG 228 Query: 205 ECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVI 264 E + + + I + S N +++ IR +++ ++++ VEL EH+ Sbjct: 229 EALSEMAAG-APINQICFSPN-RYWMCAATEKGIRIFDL--ENKDIIVELAPEHQ---GS 281 Query: 265 NKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETT 300 K+ C+ + + + S G + + + +W + Sbjct: 282 KKIVPECVSIAWSADGSTLYS--GYTDNVIRVWGVS 315 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 37/219 (16%), Positives = 70/219 (31%), Gaps = 57/219 (26%) Query: 23 IENPLRTECLQFSPCGD------------------------------------------- 39 + + + FSP Sbjct: 106 LGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLD 165 Query: 40 --YLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK 97 + G + + ++D+ T R + L H +TS+ SPDG L +S +D + Sbjct: 166 APVIVSGGWDNLVKVWDLATGRLV----TDLKGHTNYVTSVTVSPDGSLCASSDKDGVAR 221 Query: 98 LWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKS 157 LWDL+K + L E+ +PI + + +C AT E + D N + L+ Sbjct: 222 LWDLTK-GEALSEMAAGAPINQICFSPNRYWMCAAT---EKGIRIFDLENKDIIVELAPE 277 Query: 158 DEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY 196 + P+ V + + + G + + + Sbjct: 278 HQGSKKIVPE----CVSIAWSADGSTLYSGYTDNVIRVW 312 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 35/89 (39%), Gaps = 4/89 (4%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI-- 75 + + + FSP ++ G + I+D++ I + + Sbjct: 229 EALSEMAAGAPINQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKKIVPE 287 Query: 76 -TSIAWSPDGRLLLTSSRDWSIKLWDLSK 103 SIAWS DG L + D I++W +S+ Sbjct: 288 CVSIAWSADGSTLYSGYTDNVIRVWGVSE 316 >3FM0-A nrPDB Length = 345 Score = 124 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 53/331 (16%), Positives = 112/331 (33%), Gaps = 31/331 (9%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 L ++P G LA + + I+ + IC + H R + +AWSP G L ++S Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSV-LSEGHQRTVRKVAWSPCGNYLASAS 80 Query: 92 RDWSIKLW--DLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDP 149 D + +W + ++ + W + +AT + +V + + Sbjct: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN--LLATCSRDKSVWVWEVDEED 138 Query: 150 VASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHS 209 + +S H + V ++ + + Y+ C + Sbjct: 139 E--------YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEED-DWVCCAT 189 Query: 210 LKITSSNIKHLIVSQNGERLAINCSDRTIRQY-------EISIDDENSAVELTLEHKYQD 262 L+ S + L +G+RLA DRT+R + E + S Sbjct: 190 LEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSG 249 Query: 263 VINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSG------TLVRVLE-GAEEEL 315 ++ ++ A +A+ G A ++ + S +L L +++ Sbjct: 250 FHSRTIYDIAWCQLTGA---LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDV 306 Query: 316 IDINWDFYSMSIVSNGFESGNVYVWSVVIPP 346 + W+ ++++ + G V W P Sbjct: 307 NCVAWNPKEPGLLASCSDDGEVAFWKYQRPE 337 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 49/284 (17%), Positives = 96/284 (33%), Gaps = 50/284 (17%) Query: 17 EKLTHTIENPL-RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 + T+E + + ++P G+ LA + ++ ++++D ++L +H + + Sbjct: 95 FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE-CVSVLNSHTQDV 153 Query: 76 TSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIF 135 + W P LL ++S D ++KL+ + C L+ + F Sbjct: 154 KHVVWHPSQELLASASYDDTVKLYREEEDD-----------WVCCATLEGHESTVWSLAF 202 Query: 136 EESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDF 195 + S + S+D + P + + C+ Sbjct: 203 DPSGQRLASCSDDRTVRIWR-------QYLPGNEQGVACSG------------------- 236 Query: 196 YKFHSLYQTECIHSLKI-TSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 S +CI +L S I + Q LA C D IR ++ +D NS + Sbjct: 237 ----SDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQ---EDPNSDPQQ 289 Query: 255 TLEHKYQDVINKLQWNCILFSNNTAEY-LVASTHGSSAHELYIW 297 + + + N E L+AS S E+ W Sbjct: 290 PTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASC--SDDGEVAFW 331 Score = 54.5 bits (129), Expect = 9e-08, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 47/126 (37%), Gaps = 14/126 (11%) Query: 219 HLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNT 278 L + G LA DR IR + + ++ + L +Q + K+ W+ Sbjct: 21 FLAWNPAGTLLASCGGDRRIRIW--GTEGDSWICKSVLSEGHQRTVRKVAWSPC------ 72 Query: 279 AEYLVASTHGSSAHELYIWETTSG--TLVRVLEGAEEELIDINWDFYSMSIVSNGFESGN 336 YL ++ S IW+ V LEG E E+ + W + + + Sbjct: 73 GNYLASA---SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS-RDKS 128 Query: 337 VYVWSV 342 V+VW V Sbjct: 129 VWVWEV 134 >5YZG-W nrPDB Length = 579 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 42/318 (13%), Positives = 98/318 (30%), Gaps = 26/318 (8%) Query: 25 NPLRTECLQFSP-CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 + ++ P G L + + ++++ R H + + I ++ Sbjct: 287 HTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCL---RTFIGHSKAVRDICFNTA 343 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 143 G L+++ D +KLWD + P + ++ E+ + Sbjct: 344 GTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPD----------EDKQNLFV 392 Query: 144 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 +D + + H + V + + L +++ Sbjct: 393 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVD 452 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 + I + S + +S NG+ LA D I + + ++ H Sbjct: 453 FKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGY 510 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFY 323 + + FS + + + +G +L IW+ + L + ++ I W + Sbjct: 511 ACQ-----VDFSPDMSYVISGDGNG----KLNIWDWKTTKLYSRFKAHDKVCIGAVWHPH 561 Query: 324 SMSIVSNGFESGNVYVWS 341 S V G + +W Sbjct: 562 ETSKVITCGWDGLIKLWD 579 >6QDV-o nrPDB Length = 513 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 42/318 (13%), Positives = 98/318 (30%), Gaps = 26/318 (8%) Query: 25 NPLRTECLQFSP-CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 + ++ P G L + + ++++ R H + + I ++ Sbjct: 221 HTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCL---RTFIGHSKAVRDICFNTA 277 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 143 G L+++ D +KLWD + P + ++ E+ + Sbjct: 278 GTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPD----------EDKQNLFV 326 Query: 144 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 +D + + H + V + + L +++ Sbjct: 327 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVD 386 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 + I + S + +S NG+ LA D I + + ++ H Sbjct: 387 FKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGY 444 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFY 323 + + FS + + + +G +L IW+ + L + ++ I W + Sbjct: 445 ACQ-----VDFSPDMSYVISGDGNG----KLNIWDWKTTKLYSRFKAHDKVCIGAVWHPH 495 Query: 324 SMSIVSNGFESGNVYVWS 341 S V G + +W Sbjct: 496 ETSKVITCGWDGLIKLWD 513 >3DM0-A nrPDB Length = 694 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 56/329 (17%), Positives = 116/329 (35%), Gaps = 54/329 (16%) Query: 37 CGDYLALGCANGALVIYDM-DTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWS 95 D + + +++++ + + V L H + + S DG+ L+ S D Sbjct: 394 NADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGE 453 Query: 96 IKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLS 155 ++LWDL+ + + + + R++ A S D L + Sbjct: 454 LRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSA-------------SRDRTIKLWN 500 Query: 156 KSDEKQLSSTPD---HGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKI 212 E + + + H + C + + + S W K +L + +L Sbjct: 501 TLGECKYTISEGGEGHRDWVSCVRFSPN-TLQPTIVSASWDKTVKVWNLSNCKLRSTLAG 559 Query: 213 TSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCI 272 + + + VS +G A D + ++++ + ++E + + Sbjct: 560 HTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLE-----------ANSVIHAL 608 Query: 273 LFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLE---GAEEELID------------ 317 FS N +L A+T H + IW+ S ++V L+ AE E D Sbjct: 609 CFSPNR-YWLCAAT----EHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVI 663 Query: 318 ----INWDFYSMSIVSNGFESGNVYVWSV 342 +NW ++ S G+ G + VW + Sbjct: 664 YCTSLNWSADGSTLFS-GYTDGVIRVWGI 691 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 101/283 (35%), Gaps = 26/283 (9%) Query: 22 TIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS 81 + E + S G + G +G L ++D+ V H + + S+A+S Sbjct: 426 LTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAG----VSTRRFVGHTKDVLSVAFS 481 Query: 82 PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 D R ++++SRD +IKLW+ K + CV Sbjct: 482 LDNRQIVSASRDRTIKLWNTLGECKYTISEGGEG--------HRDWVSCVRFSPNTLQPT 533 Query: 142 VIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSL 201 ++ S D + + S+ K S+ H + + ++ G G + L Sbjct: 534 IVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLL---WDL 590 Query: 202 YQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQ 261 + + ++SL+ +S I L S N ++ I+ +++ +++ L+ + + Sbjct: 591 AEGKKLYSLE-ANSVIHALCFSPN-RYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAE 648 Query: 262 DVIN-------KLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 N + C + + + S G + + +W Sbjct: 649 KADNSGPAATKRKVIYCTSLNWSADGSTLFS--GYTDGVIRVW 689 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 28/144 (19%), Positives = 51/144 (35%), Gaps = 13/144 (9%) Query: 18 KLTHTIE-NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 KL T+ + + SP G A G +G ++++D+ + + H Sbjct: 552 KLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHA---- 607 Query: 77 SIAWSPDGRLLLTSSRDWSIKLWDLSKPS------KPLKEIRFDSPIWGCQWLDAKRRLC 130 + +SP R L ++ + IK+WDL S LK + G K C Sbjct: 608 -LCFSP-NRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYC 665 Query: 131 VATIFEESDAYVIDFSNDPVASLL 154 + + + + D V + Sbjct: 666 TSLNWSADGSTLFSGYTDGVIRVW 689 >6CHG-A nrPDB Length = 312 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 47/297 (15%), Positives = 104/297 (35%), Gaps = 33/297 (11%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 + + Q SP G+ +A+ C N +++Y++ + + + + H I + WSPD Sbjct: 11 ASGKISTSCQISPDGELIAI-CQNTDMLVYEISSSKMMKLTTT----HKECINCLCWSPD 65 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 143 + + + S D+++++ + + + + +P+ + + Sbjct: 66 SKCIASGSEDFTVEITHII-YGRIRRLMGHTAPVISICY-------------NNKGNILC 111 Query: 144 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 S D L + H +V K + I+ S + + Sbjct: 112 SSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGS--YDGLIRIFDTES 169 Query: 204 TECIHSLKITSS--------NIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELT 255 C+ +L I + S+NG+ L + D ++ +E V T Sbjct: 170 GHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEY----TRGTVVRT 225 Query: 256 LEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAE 312 +Q+ KL++NC L G+ + + +W S LV+ ++ Sbjct: 226 FLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKH 282 Score = 75.3 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 29/189 (15%), Positives = 60/189 (31%), Gaps = 12/189 (6%) Query: 22 TIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS 81 T + CL +SP +A G + + I I L H P+ SI ++ Sbjct: 50 TTTHKECINCLCWSPDSKCIASGSEDFTVEI-----THIIYGRIRRLMGHTAPVISICYN 104 Query: 82 PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 G +L +SS D SIK W + + + +++ + Sbjct: 105 NKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDI-PKFDSSILSSGSYDGLIR 163 Query: 142 VIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSL 201 + D + L+ + D + +++ ++V K + K Sbjct: 164 IFDTESGHCLKTLTYD---KDWIAEDGVVPISTVKFSRNGKFLLV---KSLDNVVKLWEY 217 Query: 202 YQTECIHSL 210 + + + Sbjct: 218 TRGTVVRTF 226 Score = 51.0 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 25/179 (13%), Positives = 58/179 (32%), Gaps = 19/179 (10%) Query: 163 SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIV 222 P G + + +I + + L + + ++ + I L Sbjct: 7 QVLPASGKISTSCQISPDGELIAICQNTDML----VYEISSSKMMKLTTTHKECINCLCW 62 Query: 223 SQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYL 282 S + + +A D T+ I + + H + I ++N Sbjct: 63 SPDSKCIASGSEDFTVEITHIIY----GRIRRLMGHTAPVIS-------ICYNNKGNIL- 110 Query: 283 VASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 S + W SGT ++ + + ++ I+ + SI+S+G G + ++ Sbjct: 111 ---CSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFD 166 >5OPT-p nrPDB Length = 318 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 54/315 (17%), Positives = 107/315 (33%), Gaps = 46/315 (14%) Query: 42 ALGCANGALVIY--DMDTFRPIC---VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSI 96 + L+ + +MD C P L H ++ +A S +G +++S D S+ Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSL 91 Query: 97 KLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSK 156 +LW+L K + + + R+ ++ D + + Sbjct: 92 RLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQ-------------IVSGGRDNALRVWNV 138 Query: 157 SDEKQLSSTP--DHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITS 214 + L + H + C + ++ S GW + K + + LK + Sbjct: 139 -KGECLHTLGRGAHTDWVSCVRFSPSLETPLI-VSGGWDNLVKVWDIASGRLLTDLKGHT 196 Query: 215 SNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILF 274 + I + VS +G A + D R +++ T ++ N I F Sbjct: 197 NYITSVTVSPDGSLCASSDKDGVARLWDL-----------TKGEALSEMAAGAPINQICF 245 Query: 275 SNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL-------EGAEEELIDINWDFYSMSI 327 S N A+ G + I++ + ++ L E + I W ++ Sbjct: 246 SPNRYWMCAATEKG-----IRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTL 300 Query: 328 VSNGFESGNVYVWSV 342 S G+ + VWSV Sbjct: 301 YS-GYTDNVIRVWSV 314 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 37/287 (12%), Positives = 99/287 (34%), Gaps = 28/287 (9%) Query: 14 EHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 PE+ + + S GD+ + +L ++++ T V + H + Sbjct: 57 GFPERRLE--GHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTG----VCQHKFLGHTK 110 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + S+ +SPD R +++ RD ++++W++ + L + + CV Sbjct: 111 DVLSVTFSPDNRQIVSGGRDNALRVWNVK--GECLHTLGRGA--------HTDWVSCVRF 160 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWL 193 ++ D + + + + L+ H + + ++ G Sbjct: 161 SPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDG-- 218 Query: 194 DFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVE 253 + L + E + + + I + S N +++ IR +++ D + Sbjct: 219 -VARLWDLTKGEALSEMAAG-APINQICFSPN-RYWMCAATEKGIRIFDLENKDVIVELA 275 Query: 254 LTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETT 300 + K + C+ + + + S G + + + +W + Sbjct: 276 PEAQQKSKKTP-----ECMSIAWSADGNTLYS--GYTDNVIRVWSVS 315 Score = 41.8 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 33/89 (37%), Gaps = 4/89 (4%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFR---PICVPGNMLGAHVRP 74 + + + FSP ++ G + I+D++ + Sbjct: 229 EALSEMAAGAPINQICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQKSKKTPE 287 Query: 75 ITSIAWSPDGRLLLTSSRDWSIKLWDLSK 103 SIAWS DG L + D I++W +S+ Sbjct: 288 CMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 >5Z56-q nrPDB Length = 504 Score = 117 bits (293), Expect = 9e-27, Method: Composition-based stats. Identities = 47/297 (15%), Positives = 102/297 (34%), Gaps = 33/297 (11%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSI 96 + + G A+ +V++D + + + L H + +TS+ + P L+ ++S D +I Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILA----TLKGHTKKVTSVVFHPSQDLVFSASPDATI 288 Query: 97 KLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSK 156 ++W + S +S + G L ++ + FS+ +L+K Sbjct: 289 RIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQY-----WAFSDIQTGRVLTK 343 Query: 157 SDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSN 216 + G L C I GT + K L + + + S Sbjct: 344 ------VTDETSGCSLTCAQFHPDGLIFGTGTMDSQI---KIWDLKERTNVANFPGHSGP 394 Query: 217 IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN 276 I + S+NG LA D +++ +++ ++L N + ++F Sbjct: 395 ITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLD---------NNFEVKSLIFD- 444 Query: 277 NTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFE 333 + YL + W ++ + + ++ I S G + Sbjct: 445 QSGTYLALGGTDVQIYICKQWT----EILH-FTEHSGLTTGVAFGHHAKFIASTGMD 496 Score = 98.4 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 36/236 (15%), Positives = 81/236 (34%), Gaps = 23/236 (9%) Query: 11 VLKEHPEKLTHTIE-NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLG 69 V + E++ T++ + + + F P D + + + I+ + P ++ Sbjct: 248 VFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV----PNASCVQVVR 303 Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRL 129 AH +T ++ G LL+SS D W S + GC Sbjct: 304 AHESAVTGLSLHATGDYLLSSSDDQY---WAFSDIQTGRVLTKVTDETSGC--------S 352 Query: 130 CVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTS 189 F + D + + +++ P H + +++ + Sbjct: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD 412 Query: 190 KGWLDFYKFHSLYQTECIHSLKITSS-NIKHLIVSQNGERLAINCSD---RTIRQY 241 + + L + +L++ ++ +K LI Q+G LA+ +D +Q+ Sbjct: 413 DSSVKLWDLRKLKNFK---TLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQW 465 Score = 94.9 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 43/174 (24%), Positives = 65/174 (37%), Gaps = 18/174 (10%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + C QF P G G + + I+D+ + H PITSIA+S +G Sbjct: 349 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVAN----FPGHSGPITSIAFSENG 404 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 L T++ D S+KLWDL K K K ++ D+ + IF++S Y+ Sbjct: 405 YYLATAADDSSVKLWDLRKL-KNFKTLQLDNNF-----------EVKSLIFDQSGTYLAL 452 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKF 198 D + K + L +H + H I L FY Sbjct: 453 GGTDVQI-YICKQWTEILH-FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 36/255 (14%), Positives = 82/255 (32%), Gaps = 18/255 (7%) Query: 100 DLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDE 159 +L KP + K + S + G + + ++ D + KS E Sbjct: 197 ELVKPEELSKYRQVASHV-GLHSASIP-GILALDLCPSDTNKILTGGADKNVVVFDKSSE 254 Query: 160 KQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKH 219 + L++ H + V +++ + + + S+ C+ ++ S + Sbjct: 255 QILATLKGHTKKVTSVVFHPSQDLVFSASPDATI---RIWSVPNASCVQVVRAHESAVTG 311 Query: 220 LIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTA 279 L + G+ L + D + + S + K D + C F + Sbjct: 312 LSLHATGDYLLSSSDD---QYWAFSDIQTGRVLT-----KVTDETSGCSLTCAQFHPDGL 363 Query: 280 EYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYV 339 + G+ ++ IW+ T V G + I + + + + +V + Sbjct: 364 IF----GTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYL-ATAADDSSVKL 418 Query: 340 WSVVIPPKWSALAPD 354 W + + L D Sbjct: 419 WDLRKLKNFKTLQLD 433 >6G51-g nrPDB Length = 317 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 112/318 (35%), Gaps = 44/318 (13%) Query: 39 DYLALGCANGALVIYDMDTF-RPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK 97 D + + ++++ + +P L H ++ + S DG+ L+ S D +++ Sbjct: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 Query: 98 LWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKS 157 LWDL+ + + + + + R+ ++ S D L + Sbjct: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ-------------IVSGSRDKTIKLWNT- 134 Query: 158 DEKQLSSTPD--HGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSS 215 + D H + C + + + I+ S GW K +L + + + Sbjct: 135 LGVCKYTVQDESHSEWVSCVRFSPNSSNPII-VSCGWDKLVKVWNLANCKLKTNHIGHTG 193 Query: 216 NIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFS 275 + + VS +G A D +++ +E + D+IN L FS Sbjct: 194 YLNTVTVSPDGSLCASGGKDGQAMLWDL---NEGKHLYTLDGG---DIINAL-----CFS 242 Query: 276 NNTAEYLVASTHGSSAHELYIWETTSGTLVRVL---------EGAEEELIDINWDFYSMS 326 N +L A+T S + IW+ +V L + + + W + Sbjct: 243 PNR-YWLCAATGPS----IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQT 297 Query: 327 IVSNGFESGNVYVWSVVI 344 + + G+ V VW V I Sbjct: 298 LFA-GYTDNLVRVWQVTI 314 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 40/280 (14%), Positives = 97/280 (34%), Gaps = 26/280 (9%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + + S G + G +G L ++D+ T H + + S+A+S D Sbjct: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTT----TRRFVGHTKDVLSVAFSSDN 117 Query: 85 RLLLTSSRDWSIKLWDLSKPSK-PLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 143 R +++ SRD +IKLW+ K +++ + ++ + + Sbjct: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC--------- 168 Query: 144 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 D + + + ++ K ++ H L + ++ G G L + Sbjct: 169 --GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML---WDLNE 223 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 + +++L I L S N + +I+ +++ ++ + Sbjct: 224 GKHLYTLDGG-DIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELK---QEVISTS 278 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGT 303 C + + + + G + + + +W+ T GT Sbjct: 279 SKAEPPQCTSLAWSADGQTLFA--GYTDNLVRVWQVTIGT 316 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 27/231 (11%), Positives = 76/231 (32%), Gaps = 26/231 (11%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 + + + FS + G + + +++ +C +H ++ + +SP Sbjct: 102 VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN---TLGVCKYTVQDESHSEWVSCVRFSP 158 Query: 83 DGR--LLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDA 140 + ++++ D +K+W+L+ I + Sbjct: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGS------------- 205 Query: 141 YVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHS 200 D A L ++ K L + G ++ + + + + + + Sbjct: 206 LCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN-RYWLCAATGPSIKIWDLEG 263 Query: 201 LYQTECIHSLKITSSN------IKHLIVSQNGERLAINCSDRTIRQYEISI 245 + + I++S+ L S +G+ L +D +R ++++I Sbjct: 264 KIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 Score = 51.8 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 23/142 (16%), Positives = 54/142 (38%), Gaps = 10/142 (7%) Query: 20 THTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIA 79 T+ I + + SP G A G +G +++D++ + + I ++ Sbjct: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-----GDIINALC 240 Query: 80 WSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESD 139 +SP R L ++ SIK+WDL + + E++ + + + C + + Sbjct: 241 FSP-NRYWLCAATGPSIKIWDL-EGKIIVDELKQEVISTSSKAEPPQ---CTSLAWSADG 295 Query: 140 AYVIDFSNDPVASLLSKSDEKQ 161 + D + + + + Sbjct: 296 QTLFAGYTDNLVRVWQVTIGTR 317 Score = 46.4 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 21/94 (22%), Positives = 40/94 (42%), Gaps = 6/94 (6%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI-----CVPGNMLGAHV 72 K +T++ L FSP +L ++ I+D++ + V A Sbjct: 225 KHLYTLDGGDIINALCFSPNRYWLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 Query: 73 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSK 106 TS+AWS DG+ L D +++W ++ ++ Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 >6N9G-C nrPDB Length = 353 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 44/322 (13%), Positives = 106/322 (32%), Gaps = 35/322 (10%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + + C+ + + +G ++++D + + + + A++P G Sbjct: 62 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWD----SFTTNKEHAVTMPCTWVMACAYAPSG 117 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 + D ++ L+ + S A F SD ++ Sbjct: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAM-------HTNYLSACSFTNSDMQILT 170 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH--PNIIIVGTSKGWLDFYKFHSLY 202 S D +L + L S HG ++C N + G + Sbjct: 171 ASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMV---WDMR 227 Query: 203 QTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQD 262 +C+ + + S++ + +G+ A D T R Y++ + V + Sbjct: 228 SGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRA---DREVAIY------- 277 Query: 263 VINKLQWNCILFSNNTAEYLVAST---HGSSAHELYIWETTSGTLVRVLEGAEEELIDIN 319 I+F ++ ++ ++ G + + + +W+ G+ V +L G E + + Sbjct: 278 -----SKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLR 332 Query: 320 WDFYSMSIVSNGFESGNVYVWS 341 + +G + VW+ Sbjct: 333 VSP-DGTAFCSGSWDHTLRVWA 353 Score = 34.1 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 7/36 (19%), Positives = 15/36 (41%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIY 53 +++ + R L+ SP G G + L ++ Sbjct: 317 RVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 >4BTS-AR nrPDB Length = 343 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 57/347 (16%), Positives = 119/347 (34%), Gaps = 37/347 (10%) Query: 9 FAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDM---DTFRPICVPG 65 +L+ H + +T + + E + L G + ++I+ + + +P Sbjct: 14 RGILEGHSDWVTSIVAGFSQKE----NEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPH 69 Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 L H ++ +A S + ++SS D +++LWDL + + + S ++ + Sbjct: 70 KALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPD 129 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN--- 182 R++ A E + + + S +H + C ++ Sbjct: 130 NRQILSAGA--EREIKLWNIL--GECKFSSAEK-------ENHSDWVSCVRYSPIMKSAN 178 Query: 183 ----IIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTI 238 S GW K + + ++ K SN+ HL +S NG+ +A D+ + Sbjct: 179 KVQPFAPYFASVGWDGRLKVWNT-NFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKL 237 Query: 239 RQYEISIDDENSAVELTLEHKYQDVIN-KLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 ++I Q N KLQW + + + S A I Sbjct: 238 LIWDILNLTYPQREFDAGSTINQIAFNPKLQW--VAVGTDQGVKIFNLMTQSKAPVCTI- 294 Query: 298 ETTSGTLVRVLEGAEE---ELIDINWDFYSMSIVSNGFESGNVYVWS 341 + EG + + + W+ + + GF G + +S Sbjct: 295 ---EAEPITKAEGQKGKNPQCTSLAWNALGKKLFA-GFTDGVIRTFS 337 >5NZU-C nrPDB Length = 905 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 42/276 (15%), Positives = 103/276 (37%), Gaps = 29/276 (10%) Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 L A + S+ P +L S + S+ +W+ + D P+ +++ Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVAR 68 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 K V+ ++D + + + +++ H + C I+ Sbjct: 69 KNW-------------VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFIL 115 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ-NGERLAINCSDRTIRQYEIS 244 + + + + C + + + ++++ + + A DRTI+ +++ Sbjct: 116 TSSDDMLIKLWD-WD-KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLG 173 Query: 245 IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 304 N +E ++ +N + + +S YL++ G+ + IW+ + T Sbjct: 174 SSSPNFTLE-----GHEKGVNCIDY----YSGGDKPYLIS---GADDRLVKIWDYQNKTC 221 Query: 305 VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 V+ LEG + + ++ + I+ G E G V +W Sbjct: 222 VQTLEGHAQNVSCASFHP-ELPIIITGSEDGTVRIW 256 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 38/231 (16%), Positives = 72/231 (31%), Gaps = 20/231 (8%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 L +F +++ G + + +++ +T + +M AH I IA P Sbjct: 56 CDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERV----HMFEAHSDYIRCIAVHPTQ 111 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 +LTSS D IKLWD K + + ++ K A+ + V Sbjct: 112 PFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQ 171 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN--IIIVGTSKGWLDFYKFHSLY 202 + + H + C + + +I G K Sbjct: 172 LGSSSPN-----------FTLEGHEKGVNCIDYYSGGDKPYLISGADD---RLVKIWDYQ 217 Query: 203 QTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVE 253 C+ +L+ + N+ + D T+R + S S + Sbjct: 218 NKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLN 268 Score = 46.4 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 17/181 (9%), Positives = 50/181 (27%), Gaps = 18/181 (9%) Query: 163 SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIV 222 + ++ G + + + + + ++ ++ Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHET---QTLVKTFEVCDLPVRAAKF 65 Query: 223 SQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYL 282 + D IR + + + + + + D I CI L Sbjct: 66 VARKNWVVTGADDMQIRVFNYNTLER-----VHMFEAHSDYI-----RCIAVHPTQPFIL 115 Query: 283 VASTHGSSAHELYIWETTSG-TLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 + S + +W+ + +V EG ++ I + + ++ + VW Sbjct: 116 TS----SDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQ 171 Query: 342 V 342 + Sbjct: 172 L 172 Score = 38.3 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 17/43 (39%), Gaps = 1/43 (2%) Query: 18 KLTHTIENPLR-TECLQFSPCGDYLALGCANGALVIYDMDTFR 59 T+E + C F P + G +G + I+ T+R Sbjct: 220 TCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYR 262 >4LG8-A nrPDB Length = 354 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 48/297 (16%), Positives = 102/297 (34%), Gaps = 33/297 (11%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSI 96 + + G A+ +V++D + + + L H + +TS+ + P L+ ++S D +I Sbjct: 83 DTNKILTGGADKNVVVFDKSSEQILA----TLKGHTKKVTSVVFHPSQDLVFSASPDATI 138 Query: 97 KLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSK 156 ++W + S +S + G L ++ D FS+ +L+K Sbjct: 139 RIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSS-----DDQYWAFSDIQTGRVLTK 193 Query: 157 SDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSN 216 + G L C I GT + K L + + + S Sbjct: 194 ------VTDETSGCSLTCAQFHPDGLIFGTGTMDSQI---KIWDLKERTNVANFPGHSGP 244 Query: 217 IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN 276 I + S+NG LA D +++ +++ ++L N + ++F Sbjct: 245 ITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLD---------NNFEVKSLIFD- 294 Query: 277 NTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFE 333 + YL + W ++ + + ++ I S G + Sbjct: 295 QSGTYLALGGTDVQIYICKQWT----EILH-FTEHSGLTTGVAFGHHAKFIASTGMD 346 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 36/236 (15%), Positives = 81/236 (34%), Gaps = 23/236 (9%) Query: 11 VLKEHPEKLTHTIE-NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLG 69 V + E++ T++ + + + F P D + + + I+ + P ++ Sbjct: 98 VFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV----PNASCVQVVR 153 Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRL 129 AH +T ++ G LL+SS D W S + GC Sbjct: 154 AHESAVTGLSLHATGDYLLSSSDDQY---WAFSDIQTGRVLTKVTDETSGC--------S 202 Query: 130 CVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTS 189 F + D + + +++ P H + +++ + Sbjct: 203 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD 262 Query: 190 KGWLDFYKFHSLYQTECIHSLKITSS-NIKHLIVSQNGERLAINCSD---RTIRQY 241 + + L + +L++ ++ +K LI Q+G LA+ +D +Q+ Sbjct: 263 DSSVKLWDLRKLKNFK---TLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQW 315 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 43/174 (24%), Positives = 65/174 (37%), Gaps = 18/174 (10%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + C QF P G G + + I+D+ + H PITSIA+S +G Sbjct: 199 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVAN----FPGHSGPITSIAFSENG 254 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 L T++ D S+KLWDL K K K ++ D+ + IF++S Y+ Sbjct: 255 YYLATAADDSSVKLWDLRKL-KNFKTLQLDNNF-----------EVKSLIFDQSGTYLAL 302 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKF 198 D + K + L +H + H I L FY Sbjct: 303 GGTDVQI-YICKQWTEILH-FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 91.1 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 36/255 (14%), Positives = 82/255 (32%), Gaps = 18/255 (7%) Query: 100 DLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDE 159 +L KP + K + S + G + + ++ D + KS E Sbjct: 47 ELVKPEELSKYRQVASHV-GLHSASIP-GILALDLCPSDTNKILTGGADKNVVVFDKSSE 104 Query: 160 KQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKH 219 + L++ H + V +++ + + + S+ C+ ++ S + Sbjct: 105 QILATLKGHTKKVTSVVFHPSQDLVFSASPDATI---RIWSVPNASCVQVVRAHESAVTG 161 Query: 220 LIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTA 279 L + G+ L + D + + S + K D + C F + Sbjct: 162 LSLHATGDYLLSSSDD---QYWAFSDIQTGRVLT-----KVTDETSGCSLTCAQFHPDGL 213 Query: 280 EYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYV 339 + G+ ++ IW+ T V G + I + + + + +V + Sbjct: 214 IF----GTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYL-ATAADDSSVKL 268 Query: 340 WSVVIPPKWSALAPD 354 W + + L D Sbjct: 269 WDLRKLKNFKTLQLD 283 >4V6W-Ag nrPDB Length = 318 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 60/337 (17%), Positives = 117/337 (34%), Gaps = 46/337 (13%) Query: 22 TIENPLRTECLQFSPCG-DYLALGCANGALVIYDM--DTFRPICVPGNMLGAHVRPITSI 78 I + + +P D + + L+++ + D P L H I+ + Sbjct: 11 LIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDV 70 Query: 79 AWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEES 138 S DG L+ S D +++LWDL+ + + + R+ Sbjct: 71 VLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQ---------- 120 Query: 139 DAYVIDFSNDPVASLLSK-SDEKQLSSTPDHGYVLVCTVHTK-HPNIIIVGTSKGWLDFY 196 ++ S D L + ++ K H + C + H N IIV S GW Sbjct: 121 ---IVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIV--SCGWDRTV 175 Query: 197 KFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTL 256 K +L + ++ + + + VS +G D ++++ +E Sbjct: 176 KVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE--- 232 Query: 257 EHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL-------- 308 + D+IN L FS N Y + +G S + IW+ V L Sbjct: 233 ---HNDIINAL-----CFSPN--RYWLCVAYGPS---IKIWDLACKKTVEELRPEVVSPT 279 Query: 309 -EGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVI 344 + + + + + W ++ + G+ + VW V + Sbjct: 280 SKADQPQCLSLAWSTDGQTLFA-GYSDNTIRVWQVSV 315 >4V7E-Bg nrPDB Length = 380 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 42/326 (12%), Positives = 113/326 (34%), Gaps = 27/326 (8%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + + L ++P +++ +G L++++ T + + + H + A++P+G Sbjct: 65 HSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQ----KTHAIKLHCPWVMECAFAPNG 120 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 + + D + +++LS + + P+ + + +I Sbjct: 121 QSVACGGLDSACSIFNLSSQADRDGNM----PVSRVLTGHKGY-ASSCQYVPDQETRLIT 175 Query: 145 FSNDPVASLLSKSDEKQLSST-----PDHGYVLVCTVHTK-HPNIIIVGTSKGWLDFYKF 198 S D L + +++S H ++ + N+ I G+ + + Sbjct: 176 GSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDL 235 Query: 199 HSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEH 258 + + + +I + +G+R D T R +++ +++ Sbjct: 236 RIT--SRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRT---GHQLQVYNRE 290 Query: 259 KYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLV---RVLEGAEEEL 315 ++ + FS + ++G + Y+W+T +V L+ + E Sbjct: 291 PDRNDNELPIVTSVAFSISGRLLFAGYSNG----DCYVWDTLLAEMVLNLGTLQNSHEGR 346 Query: 316 IDINWDFYSMSIVSNGFESGNVYVWS 341 I S + G N+ +W+ Sbjct: 347 ISCLGLSSDGSALCTGSWDKNLKIWA 372 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 35/235 (14%), Positives = 77/235 (32%), Gaps = 31/235 (13%) Query: 22 TIENPLRTECLQFSPCGD-YLALGCANGALVIYDMDTFRPICVPGNML-GAHVRPITSIA 79 + Q+ P + L G + V++D+ T + I + G+ H + S++ Sbjct: 153 LTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLS 212 Query: 80 WSP-DGRLLLTSSRDWSIKLWDLSKPSKPLKEI-RFDSPIWGCQWLDAKRRLCVATIFEE 137 + + + ++ S D +++LWDL S+ ++ + I ++ Sbjct: 213 INSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDG----------- 261 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSST-------PDHGYVLVCTVHTKHPNIIIVGTSK 190 S+D L QL + ++ + ++ G S Sbjct: 262 --QRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSN 319 Query: 191 GWLDFYKFHSLYQTECIHSL----KITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 G E + +L I L +S +G L D+ ++ + Sbjct: 320 GDCYV---WDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 61.8 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 49/141 (34%), Gaps = 12/141 (8%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRP---ITSIAWS 81 + ++F P G G +G ++DM T + V + +TS+A+S Sbjct: 248 HEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFS 307 Query: 82 PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 GRLL + +WD L + Q R C+ + + Sbjct: 308 ISGRLLFAGYSNGDCYVWDTLLAEMVL-------NLGTLQNSHEGRISCLGLSSD--GSA 358 Query: 142 VIDFSNDPVASLLSKSDEKQL 162 + S D + + S +++ Sbjct: 359 LCTGSWDKNLKIWAFSGHRKI 379 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 22/91 (24%), Positives = 37/91 (40%) Query: 12 LKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH 71 L+ + + + FS G L G +NG ++D + G + +H Sbjct: 284 LQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSH 343 Query: 72 VRPITSIAWSPDGRLLLTSSRDWSIKLWDLS 102 I+ + S DG L T S D ++K+W S Sbjct: 344 EGRISCLGLSSDGSALCTGSWDKNLKIWAFS 374 Score = 52.6 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 21/183 (11%), Positives = 56/183 (30%), Gaps = 41/183 (22%) Query: 206 CIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVIN 265 C +L+ S + L + + D + + + A++L + Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFA 117 Query: 266 ---------KLQWNCILFS-----------------------NNTAEYLVAST----HGS 289 L C +F+ ++ +Y+ GS Sbjct: 118 PNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGS 177 Query: 290 SAHELYIWETTSGTLVRVLE-----GAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVI 344 +W+ T+G + + G +++ ++ + + ++ +G V +W + I Sbjct: 178 GDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRI 237 Query: 345 PPK 347 + Sbjct: 238 TSR 240 >6ID0-T nrPDB Length = 514 Score = 111 bits (277), Expect = 6e-25, Method: Composition-based stats. Identities = 43/289 (14%), Positives = 90/289 (31%), Gaps = 37/289 (12%) Query: 15 HPEKLTHTIENPLR-TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 P KL I L C+ P + G A+ + I+D+ + + L H+ Sbjct: 192 PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL----SLTGHIS 247 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + + S L + D +K WDL S ++G Sbjct: 248 TVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHP--------- 298 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWL 193 + ++ S D A + + + + H + II G+ + Sbjct: 299 ----TIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTI 354 Query: 194 DFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVE 253 + L + +L +++ +++ A D I+Q++ + S ++ Sbjct: 355 ---RLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKF---PDGSFIQ 407 Query: 254 LTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSG 302 H + N+ LV+ + H +W+ +G Sbjct: 408 NLSGHNAIINT---------LTVNSDGVLVSGADNGTMH---LWDWRTG 444 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 42/283 (14%), Positives = 94/283 (33%), Gaps = 33/283 (11%) Query: 59 RPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIW 118 P ++ H+ + IA P + +T S D +IK+WDL+ L S + Sbjct: 191 HPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTV- 249 Query: 119 GCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHT 178 R + V+T Y+ D K + H + Sbjct: 250 --------RGVIVSTRS----PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLH 297 Query: 179 KHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTI 238 ++++ + + + +H+L ++ + + ++ D TI Sbjct: 298 PTIDVLVTCSRDSTA---RIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTI 354 Query: 239 RQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 298 R +++ HK + + Y AS GS + + W+ Sbjct: 355 RLWDLVA---GKTRVTLTNHK---------KSVRAVVLHPRHYTFAS--GSPDN-IKQWK 399 Query: 299 TTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 G+ ++ L G + + + + + +G ++G +++W Sbjct: 400 FPDGSFIQNLSGHNAIINTLTVNSDGV--LVSGADNGTMHLWD 440 Score = 88.8 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 37/234 (15%), Positives = 73/234 (31%), Gaps = 26/234 (11%) Query: 14 EHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 E+ + + H + L P D L + I+D+ T + + L H Sbjct: 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV----HTLSGHTN 331 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + ++ ++T S D +I+LWDL + + Sbjct: 332 AVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRH------- 384 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWL 193 Y + D + + H ++ +++ G G + Sbjct: 385 -------YTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT-VNSDGVLVSGADNGTM 436 Query: 194 DFYKFHSLYQTECIH------SLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 + + + Y + +H SL S I Q+ RL +D+TI+ Y Sbjct: 437 HLWDWRTGYNFQRVHAAVQPGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489 >5Y88-O nrPDB Length = 451 Score = 111 bits (276), Expect = 7e-25, Method: Composition-based stats. Identities = 52/331 (15%), Positives = 109/331 (32%), Gaps = 34/331 (10%) Query: 16 PEKLTHTIENPLR-TECLQFSP-CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 P KL+ I L C+ P ++ G + + ++D+ T + L HV Sbjct: 128 PWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGK----LKTTLAGHVM 183 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + +A S L + S D ++K WDL K S + Sbjct: 184 TVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHP--------- 234 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWL 193 + + D V L + + H + T ++ ++ + Sbjct: 235 ----TLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATV 290 Query: 194 DFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVE 253 + + + + L +++ + +A C+D IR + ++ ++ Sbjct: 291 ---RLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDD-IRSWGLA----EGSLL 342 Query: 254 LTLEHKYQDVINKLQWNC--ILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGA 311 E + +IN L N +LF+ L + S + +V LEG Sbjct: 343 TNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQ---SLATREMVGSLEG- 398 Query: 312 EEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 E ++ +D + ++ G ++ +W Sbjct: 399 ERSVLCSTFDKTGLRLI-TGEADKSIKIWKQ 428 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 41/288 (14%), Positives = 91/288 (31%), Gaps = 33/288 (11%) Query: 66 NMLGAHVRPITSIAWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLD 124 ++ H+ + +A P D +T S D ++K+WDL+ + D Sbjct: 133 RVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSD 192 Query: 125 AKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNII 184 Y+ S D + + H + ++I Sbjct: 193 RH-------------PYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLI 239 Query: 185 IVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 244 G K + + +L I + + ++ + +D T+R +++ Sbjct: 240 ATA---GRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVV 296 Query: 245 IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 304 +++ HK L + E+ VAS ++ W G+L Sbjct: 297 A---GKTMKVLTHHKRSVRATAL---------HPKEFSVASACTD---DIRSWGLAEGSL 341 Query: 305 VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALA 352 + E + +I+ + + G ++G + + K+ +LA Sbjct: 342 LTNFESEKTGIINTLSINQDDVLFAGG-DNGVLSFYDYKSGHKYQSLA 388 Score = 32.9 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 23/66 (34%), Gaps = 11/66 (16%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 ++ ++E C F G L G A+ ++ I+ D Sbjct: 391 EMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEP-----------G 439 Query: 78 IAWSPD 83 +AW+P+ Sbjct: 440 LAWNPN 445 >2HES-X nrPDB Length = 330 Score = 110 bits (275), Expect = 9e-25, Method: Composition-based stats. Identities = 53/321 (16%), Positives = 105/321 (32%), Gaps = 24/321 (7%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 F LA G + + + + + AH + I S+AW P LL S Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSF 78 Query: 93 DWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 D ++ +W +K + D ++ + Y+ S D Sbjct: 79 DSTVSIW--AKEESADRTFEMDL----LAIIEGHENEVKGVAWSNDGYYLATCSRDKSVW 132 Query: 153 LLSK----SDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIH 208 + + + +S +H + + ++ + + +K + EC+ Sbjct: 133 IWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDD-DWECVA 191 Query: 209 SLKITSSNIKHLIVSQN--GERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINK 266 L + + RL D T+R ++ DDE+ E E DV + Sbjct: 192 VLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKR 251 Query: 267 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGT----LVRVLEGAEEELIDINW-D 321 +N + + + + L ++E G R L E+ + W + Sbjct: 252 QVYN---VAWGFNGLIASV---GADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLE 305 Query: 322 FYSMSIVSNGFESGNVYVWSV 342 +I++ G + G V WS+ Sbjct: 306 LNGKTILATGGDDGIVNFWSL 326 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 78/225 (34%), Gaps = 10/225 (4%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + + + +S G YLA + ++ I++ D ++L H + + + W P Sbjct: 106 HENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSE 165 Query: 85 RLLLTSSRDWSIKLW-DLSKPSKPLKEI-RFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 LL +SS D ++++W D + + + + +W + + + + ++S V Sbjct: 166 ALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRV 225 Query: 143 IDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK----F 198 + D E L V +I + G L Y+ Sbjct: 226 WKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFN---GLIASVGADGVLAVYEEVDGE 282 Query: 199 HSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 ++ + + +K L ++ LA D + + + Sbjct: 283 WKVFAKRALCHGVYEINVVKWLELNGK-TILATGGDDGIVNFWSL 326 >1NR0-A nrPDB Length = 611 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 44/354 (12%), Positives = 118/354 (33%), Gaps = 50/354 (14%) Query: 10 AVLKEHPEKLTHTI-ENPLRTECLQFSPCGDYLALGCANGALVIYD-MDTFRPICVPGNM 67 A+ + P K T E+ ++++P G A +G +V+Y+ +D + + Sbjct: 173 AIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS 232 Query: 68 LG--AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 L AH + + WSPDG + ++S D +IK+W+++ ++ + I ++ Sbjct: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT-------LKVEKTIPVGTRIED 285 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 ++ + T ++ S + + ++ H + + + Sbjct: 286 QQLGIIWT-----KQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLF 340 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQ----- 240 ++G ++ + + + ++ I + + G+ ++ D Sbjct: 341 SADAEGHINSWDISTGISNRVFPD--VHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGS 398 Query: 241 ------------------------YEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN 276 +I++ + + K +V +C+ SN Sbjct: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSN 458 Query: 277 NTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSN 330 + V S H + + + ++ E+ + + +V+ Sbjct: 459 DKQFVAVGGQD-SKVHVYKLSGASVSEVKTIV--HPAEITSVAFSNNGAFLVAT 509 Score = 90.7 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 48/328 (14%), Positives = 106/328 (32%), Gaps = 38/328 (11%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 E+ +T + SP G Y A G +G + I+D T + + + P+ I+W Sbjct: 56 TEHSHQTTVAKTSPSGYYCASGDVHGNVRIWD--TTQTTHILKTTIPVFSGPVKDISWDS 113 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKE-IRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 + + + + + + FD+ R + Sbjct: 114 ESKRIAA-----------VGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFR 162 Query: 142 VIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSL 201 +I S+D ++ K S+ +H + + ++ G + Y Sbjct: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 Query: 202 YQTECIHSLKI----TSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLE 257 +T + S ++ L S +G ++A +D+TI+ + ++ + + Sbjct: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT--IPVG 280 Query: 258 HKYQDVINKLQWN---CILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEE 314 + +D + W + S N V GS Y G + Sbjct: 281 TRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRY--------------GHNKA 326 Query: 315 LIDINWDFYSMSIVSNGFESGNVYVWSV 342 + ++ ++ S E G++ W + Sbjct: 327 ITALSSSADGKTLFSADAE-GHINSWDI 353 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 37/271 (13%), Positives = 86/271 (31%), Gaps = 29/271 (10%) Query: 30 ECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 + F P + + G + + I++ P + G H + + S+ ++PDG L Sbjct: 151 NSVDFKPSRPFRIISGSDDNTVAIFE----GPPFKFKSTFGEHTKFVHSVRYNPDGSLFA 206 Query: 89 TSSRDWSIKLWDLSKPSK-------PLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 ++ D +I L++ +K LK + ++G W Sbjct: 207 STGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDG-------------TK 253 Query: 142 VIDFSNDPVASLLSKSDEKQLSSTP-DHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHS 200 + S D + + + K + P ++ ++ G+++F Sbjct: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPEL 313 Query: 201 LYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKY 260 + + + I L S +G+ L ++ I ++IS N Sbjct: 314 GSIDQVRY---GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMI 370 Query: 261 QDVINKLQWNCILFSNNTAEYLVASTHGSSA 291 + + + S + +V + Sbjct: 371 TGIKTTSKGDLFTVSWDDHLKVVPAGGSGVD 401 Score = 62.6 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 49/122 (40%), Gaps = 1/122 (0%) Query: 22 TIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS 81 TI +P + FS G +L + ++ Y + + N H + ++WS Sbjct: 487 TIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELA-HTNSWTFHTAKVACVSWS 545 Query: 82 PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 PD L T S D S+ +W+++KPS I+ + + + + ++S+ Sbjct: 546 PDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIK 605 Query: 142 VI 143 Sbjct: 606 FW 607 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 43/78 (55%), Gaps = 4/78 (5%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHV-RPITSIAWSPD 83 + + C+ +SP LA G + ++++++M+ +P P + GAH + S+ W + Sbjct: 535 HTAKVACVSWSPDNVRLATGSLDNSVIVWNMN--KPSDHPIIIKGAHAMSSVNSVIWLNE 592 Query: 84 GRLLLTSSRDWSIKLWDL 101 ++++ +D +IK W++ Sbjct: 593 -TTIVSAGQDSNIKFWNV 609 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 35/273 (12%), Positives = 75/273 (27%), Gaps = 34/273 (12%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + L S G L A G + +D+ T V ++ H IT I + G Sbjct: 323 HNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDV---HATMITGIKTTSKG 379 Query: 85 RLLLTSSRDWSIKLW-------DLSKPSKPL-------------KEIRFDSPIWGCQW-- 122 L T S D +K+ D SK +I + Sbjct: 380 D-LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYS 438 Query: 123 ------LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTV 176 + + + + + V T H + Sbjct: 439 HGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVA 498 Query: 177 HTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDR 236 + + ++ + Y + ++ +S ++ + + S + RLA D Sbjct: 499 FSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDN 558 Query: 237 TIRQYEISIDDENSAVELTLEHKYQDVINKLQW 269 ++ + + + + + +N + W Sbjct: 559 SVIVWNM--NKPSDHPIIIKGAHAMSSVNSVIW 589 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 24/173 (13%), Positives = 59/173 (34%), Gaps = 17/173 (9%) Query: 29 TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 + C+ S ++A+G + + +Y + V H ITS+A+S +G L+ Sbjct: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLS---GASVSEVKTIVHPAEITSVAFSNNGAFLV 507 Query: 89 TSSRDWSIKLWDLSKPSKPLKEIR---FDSPIWGCQWLDAKRRLCVATIFEESDAYVIDF 145 + + + + ++ + + + W + +AT ++ V + Sbjct: 508 ATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPD--NVRLATGSLDNSVIVWNM 565 Query: 146 SNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKF 198 +K + + H V +V + I+ + F+ Sbjct: 566 ---------NKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 >5UZ7-B nrPDB Length = 351 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 44/339 (12%), Positives = 106/339 (31%), Gaps = 40/339 (11%) Query: 7 DPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGN 66 DP ++ + + + + + L +G L+I+D T + + Sbjct: 49 DPVGRIQMRTRRTLR--GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV----H 102 Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLK----EIRFDSPIWGCQW 122 + + + A++P G + D +++L ++ + C++ Sbjct: 103 AIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF 162 Query: 123 LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN 182 LD + ++ S D +L +Q ++ H ++ Sbjct: 163 LDDNQ--------------IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 208 Query: 183 IIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 + + G K + + C + S+I + NG A D T R ++ Sbjct: 209 LFVSGACDASA---KLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFD 265 Query: 243 ISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSG 302 + D + + + S + + L+ + G +W+ Sbjct: 266 LRAD----------QELMTYSHDNIICGITSVSFSKSGRLLLA--GYDDFNCNVWDALKA 313 Query: 303 TLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 VL G + + + M+ V+ G + +W+ Sbjct: 314 DRAGVLAGHDNRVSCLGVTDDGMA-VATGSWDSFLKIWN 351 >5K1B-B nrPDB Length = 677 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 43/326 (13%), Positives = 114/326 (34%), Gaps = 28/326 (8%) Query: 29 TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 LQ P + L + + I+ ++ + H + I +G+ L+ Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQ-HKQDPYIASMEHHTDWVNDIVLCCNGKTLI 91 Query: 89 TSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 148 ++S D ++K+W+ K + + K + A + + ++ D + Sbjct: 92 SASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGL--DRQIFLWDV--N 147 Query: 149 PVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIH 208 + +L + ++ SS + + + II+ G+++ + + Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTE---KVLRVWDPRTCAKLM 204 Query: 209 SLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQ 268 LK + N+K L+++++G + SD TIR + + + + H Sbjct: 205 KLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL---GQQRCIATYRVH---------- 251 Query: 269 WNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEEL----IDINWDFYS 324 + +++ + G ++Y + + + ++ + + +D + D Sbjct: 252 -DEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPP 310 Query: 325 MSIVSNGFESGNVYVWSVVIPPKWSA 350 V+ V W++ + A Sbjct: 311 AIWVATTKS--TVNKWTLKGIHNFRA 334 Score = 75.3 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 78/239 (32%), Gaps = 20/239 (8%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 + N L + G + G L ++D T C L H + + Sbjct: 160 TTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT----CAKLMKLKGHTDNVKA 215 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 + + DG L+ S D +I+LW L + D +W Q DA V + + Sbjct: 216 LLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTH--VYSGGRD 273 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPD-HGYVLVCTVHTKHPNIIIVGTSKGWLDFY 196 Y D N + L+ + L D + + T KG + + Sbjct: 274 RKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKG-IHNF 332 Query: 197 KFHSLYQTECI-----------HSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 244 + Y +C +K +S I+ I++ + + ++ + +++ Sbjct: 333 RASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILN-DKRHILTKDTNNNVAYWDVL 390 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 20/135 (14%), Positives = 49/135 (36%), Gaps = 12/135 (8%) Query: 209 SLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQ 268 K + + L + RL D IR + ++ ++ + + D +N + Sbjct: 25 VEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQD--PYIASMEHHTDWVNDIV 82 Query: 269 WNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIV 328 C + L+++ SS + +W G + L ++ + + + + Sbjct: 83 LCC------NGKTLISA---SSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA 133 Query: 329 SNGFESGNVYVWSVV 343 S G + +++W V Sbjct: 134 SAGLDR-QIFLWDVN 147 >5GAN-H nrPDB Length = 465 Score = 107 bits (267), Expect = 9e-24, Method: Composition-based stats. Identities = 56/323 (17%), Positives = 118/323 (36%), Gaps = 29/323 (8%) Query: 21 HTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAW 80 + + + S +A G G L + + T +P+ L +HV I +I W Sbjct: 170 SQLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLT---QKLDSHVGKIGAIDW 226 Query: 81 SPD-GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESD 139 PD +++ + D IK + S L+ + L R + S Sbjct: 227 HPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGD---------LVGHERRISDVKYHPSG 277 Query: 140 AYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFH 199 ++ S+D L S ++L H + +++ G G Sbjct: 278 KFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSG---GMDSLSMLW 334 Query: 200 SLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHK 259 + + +L S I + S NG ++A D I ++I DE Sbjct: 335 DIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDE--------GQL 386 Query: 260 YQDVINKLQWNCILFSN-NTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDI 318 Q + ++ + FS + + LV+ + + + ++ + + + L G +++I + Sbjct: 387 NQILAHRNIVTQVRFSKEDGGKKLVSCGY---DNLINVYSSDTWLKMGSLAGHTDKIISL 443 Query: 319 NWDFYSMSIVSNGFESGNVYVWS 341 + S +VS G++ ++ +W+ Sbjct: 444 DISNNSHFLVSGGWDR-SIKLWN 465 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 20/140 (14%), Positives = 46/140 (32%), Gaps = 17/140 (12%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 K+ + + +SP G +A G +G + ++D+ + + AH +T Sbjct: 341 KVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQIL--AHRNIVTQ 398 Query: 78 IAWSPD--GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIF 135 + +S + G+ L++ D I ++ K I + Sbjct: 399 VRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSH-------- 450 Query: 136 EESDAYVIDFSNDPVASLLS 155 +++ D L + Sbjct: 451 -----FLVSGGWDRSIKLWN 465 >6HHQ-h nrPDB Length = 319 Score = 107 bits (267), Expect = 9e-24, Method: Composition-based stats. Identities = 52/316 (16%), Positives = 105/316 (33%), Gaps = 43/316 (13%) Query: 39 DYLALGCANGALVIYDMDTF-RPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK 97 + L + L+ + + + VP H + + DG L++S D +++ Sbjct: 31 NLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLR 90 Query: 98 LWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKS 157 LWD++ + + S + ++ + +I S D + + Sbjct: 91 LWDVATGETYQRFVGHKSDVMSVDI-------------DKKASMIISGSRDKTIKVWTI- 136 Query: 158 DEKQLSSTPDHGY---VLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITS 214 + L++ H + + K + + S G K +L Q + + Sbjct: 137 KGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHN 196 Query: 215 SNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILF 274 SNI L S +G +A D I + ++ + QD + L F Sbjct: 197 SNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLS------AQDEVFSLA-----F 245 Query: 275 SNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL--------EGAEEELIDINWDFYSMS 326 S N A+ G + ++ LV L + AE + + W + Sbjct: 246 SPNRYWLAAATATG-----IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQT 300 Query: 327 IVSNGFESGNVYVWSV 342 + + G+ + VW V Sbjct: 301 LFA-GYTDNVIRVWQV 315 Score = 98.0 bits (242), Expect = 7e-21, Method: Composition-based stats. Identities = 31/267 (11%), Positives = 90/267 (33%), Gaps = 23/267 (8%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSI 96 G Y + L ++D+ T H + S+ ++++ SRD +I Sbjct: 76 DGAYALSASWDKTLRLWDVATGETY----QRFVGHKSDVMSVDIDKKASMIISGSRDKTI 131 Query: 97 KLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSK 156 K+W + K + + + + + ++ ++ +I ND + + Sbjct: 132 KVWTI-KGQCLATLLGHNDWVSQVRVVPNEK-------ADDDSVTIISAGNDKMVKAWNL 183 Query: 157 SDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSN 216 + + + H + + +I G + +L + +++L Sbjct: 184 NQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIML---WNLAAKKAMYTLS-AQDE 239 Query: 217 IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN 276 + L S N LA + I+ + + + + L ++ + + + + Sbjct: 240 VFSLAFSPNRYWLAAATATG-IKVFSL----DPQYLVDDLRPEFAGYSKAAEPHAVSLAW 294 Query: 277 NTAEYLVASTHGSSAHELYIWETTSGT 303 + + + G + + + +W+ + Sbjct: 295 SADGQTLFA--GYTDNVIRVWQVMTAN 319 Score = 91.1 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 110/308 (35%), Gaps = 44/308 (14%) Query: 59 RPICVPGNMLGAHVRPITSIAWSPDG-RLLLTSSRDWSIKLW----DLSKPSKPLKEIRF 113 + V L H +TS+A S LLL++SRD ++ W D K P++ + Sbjct: 4 NEVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKG 63 Query: 114 DSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV 173 S I L A AY + S D L + + H ++ Sbjct: 64 HSHIVQDCTLTA------------DGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVM 111 Query: 174 CTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGE------ 227 K ++II G+ + + + +C+ +L + + + V N + Sbjct: 112 SVDIDKKASMIISGSRDKTIKVWTI----KGQCLATLLGHNDWVSQVRVVPNEKADDDSV 167 Query: 228 RLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTH 287 + +D+ ++ + ++ + +E + + N + S + A Sbjct: 168 TIISAGNDKMVKAWNLN--------QFQIEADFIG--HNSNINTLTASPDGTLIASAGKD 217 Query: 288 GSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPK 347 G E+ +W + + L A++E+ + + ++ +G + V+S+ Sbjct: 218 G----EIMLWNLAAKKAMYTLS-AQDEVFSLAFSPNR-YWLAAATATG-IKVFSLDPQYL 270 Query: 348 WSALAPDF 355 L P+F Sbjct: 271 VDDLRPEF 278 Score = 72.2 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 29/241 (12%), Positives = 69/241 (28%), Gaps = 31/241 (12%) Query: 17 EKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 E + + + + G + + ++ + L H ++ Sbjct: 98 ETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQ-----CLATLLGHNDWVS 152 Query: 77 SIAWSP------DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLC 130 + P D ++++ D +K W+L++ I +S I Sbjct: 153 QVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDG---- 208 Query: 131 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSK 190 + D L + + +K + + + + + + T+ Sbjct: 209 ---------TLIASAGKDGEIMLWNLAAKKAMYTLSAQD-EVFSLAFSPNRYWLAAATAT 258 Query: 191 GW-----LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISI 245 G Y L +S K + L S +G+ L +D IR +++ Sbjct: 259 GIKVFSLDPQYLVDDLRPEFAGYS-KAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMT 317 Query: 246 D 246 Sbjct: 318 A 318 Score = 30.2 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 20/55 (36%), Gaps = 1/55 (1%) Query: 6 QDP-FAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFR 59 DP + V PE ++ L +S G L G + + ++ + T Sbjct: 265 LDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 319 >5WYK-BB nrPDB Length = 943 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 33/187 (17%), Positives = 64/187 (34%), Gaps = 20/187 (10%) Query: 11 VLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA 70 VLK H + ++ L C++ SP YLA+ + + ++ +D+ + L Sbjct: 519 VLKLHHDTTLELTDDIL---CVRVSPDDRYLAISLLDNTVKVFFLDSMKFYL----SLYG 571 Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLC 130 H P+ SI S D ++++TSS D +IK+W L I ++L Sbjct: 572 HKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHN-- 629 Query: 131 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSK 190 S D V + + H + ++ + Sbjct: 630 -----------FFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHD 678 Query: 191 GWLDFYK 197 + ++ Sbjct: 679 HSIRIWE 685 Score = 91.1 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 40/257 (15%), Positives = 75/257 (29%), Gaps = 33/257 (12%) Query: 3 ILLQDPFAVLKEHPEKLTHTIE-----NPLRTECLQFSPCGDYLALGCANGALVIYDMDT 57 ++L L+ + ++ + L + G L G A+ + +D Sbjct: 445 VILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKV 504 Query: 58 FRPICVPGN-----MLGAH-------VRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPS 105 + +L H I + SPD R L S D ++K++ L Sbjct: 505 ENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMK 564 Query: 106 KPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSST 165 L P+ + +I S D + S Sbjct: 565 FYLSLYGHKLPVLSIDISFDSK-------------MIITSSADKNIKIWGLDFGDCHKSL 611 Query: 166 PDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQN 225 H ++ + + K+ + ECI L S + L V+ + Sbjct: 612 FAHQDSIMNVKFLPQSHNFFSCSKDA---VVKYWDGEKFECIQKLYAHQSEVWALAVATD 668 Query: 226 GERLAINCSDRTIRQYE 242 G + + D +IR +E Sbjct: 669 GGFVVSSSHDHSIRIWE 685 Score = 88.8 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 58/358 (16%), Positives = 125/358 (34%), Gaps = 52/358 (14%) Query: 5 LQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIY-------DMDT 57 +++ ++ HP + ++ S L L ++ + Y D + Sbjct: 317 IKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTS 376 Query: 58 FRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPI 117 P+ L + SI S D +LL T+S + S+K+W++ K K ++ + Sbjct: 377 PAPLKTHTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNI-KTHKCIRTFECGYAL 434 Query: 118 WGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPD-HGYVLVCTV 176 F VI + + L + L + D H + Sbjct: 435 TC--------------KFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLD 480 Query: 177 HTKHPNIIIVGTSKGWLDFYKFH------SLYQTECIHSLKIT-------SSNIKHLIVS 223 T ++ G++ + F+ F + + + LK+ + +I + VS Sbjct: 481 LTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVS 540 Query: 224 QNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLV 283 + LAI+ D T++ + ++ L+L +KL I S ++ + Sbjct: 541 PDDRYLAISLLDNTVKVF----FLDSMKFYLSL------YGHKLPVLSIDISFDSKMIIT 590 Query: 284 ASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 + S+ + IW G + L ++ ++++ + S + S + V W Sbjct: 591 S----SADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCS-KDAVVKYWD 643 Score = 78.0 bits (190), Expect = 7e-15, Method: Composition-based stats. Identities = 39/224 (17%), Positives = 69/224 (30%), Gaps = 21/224 (9%) Query: 14 EHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 P P L+ D LA+G A+G + ++D+ + + H Sbjct: 67 LPPGASDARGAKPAECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLN----FNGHKA 122 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 IT + + G L++ S+D +I +WDL K I G W + L Sbjct: 123 AITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITG-FWCQGEDWLIST- 180 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWL 193 S D + L + + + H C +++I + + Sbjct: 181 ------------SKDGMIKLWDLKTHQCIETHIAHTGE--CWGLAVKDDLLITTGTDSQV 226 Query: 194 DFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRT 237 +K + + L K N SD+T Sbjct: 227 KIWKL-DIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKT 269 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 67/208 (32%), Gaps = 40/208 (19%) Query: 178 TKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRT 237 K +++ VG + G K L + + + I L G RL D Sbjct: 88 HKDTDLLAVGYADG---VIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSN 144 Query: 238 IRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 I +++ V L ++D I F ++L+++ S + +W Sbjct: 145 IIVWDLV-----GEVGLYKLRSHKDSI-------TGFWCQGEDWLIST---SKDGMIKLW 189 Query: 298 ETTSGTLVRVLEGAEEELIDINW--DFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDF 355 + + + E W +++ G +S V +W + I Sbjct: 190 DLKTHQCIETHIAHTGE----CWGLAVKDDLLITTGTDS-QVKIWKLDI----------- 233 Query: 356 EEVEENVDYLEKEDEFDEVDEAEQQQGL 383 EN K E ++ +Q+GL Sbjct: 234 ----ENDKMGGKLTEMGIFEKQSKQRGL 257 >6GMH-W nrPDB Length = 305 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 39/305 (12%), Positives = 98/305 (32%), Gaps = 33/305 (10%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSI 96 + + G + + ++ L H + S+ S + +SS D I Sbjct: 31 NSETVVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHI 88 Query: 97 KLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSK 156 +LWDL + W + Y+ ++ ++ Sbjct: 89 RLWDLENGKQIKSIDAGPVDAWTLAFSPD-------------SQYLATGTHVGKVNIFGV 135 Query: 157 SDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSN 216 K+ S G ++ ++ + G G ++ + + + +H+L+ + Sbjct: 136 ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF---DIATGKLLHTLEGHAMP 192 Query: 217 IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN 276 I+ L S + + L D I+ Y++ + + N + Sbjct: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS---------GHASWVLNVAFCPD 243 Query: 277 NTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGN 336 +T +S +W+ + T V ++++ + ++ IVS G + Sbjct: 244 DTHFVSSSSDKSV-----KVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVG-DDQE 297 Query: 337 VYVWS 341 ++++ Sbjct: 298 IHIYD 302 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 39/189 (20%), Positives = 71/189 (37%), Gaps = 19/189 (10%) Query: 9 FAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNML 68 F V E T + +SP G YLA G +G + I+D+ T + + + L Sbjct: 133 FGVESGKKEYSLDT--RGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLL----HTL 186 Query: 69 GAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRR 128 H PI S+ +SPD +LL+T+S D IK++D+ + S + + Sbjct: 187 EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPD--- 243 Query: 129 LCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGT 188 D + + S+D + + + DH + + + + I+ Sbjct: 244 ----------DTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVG 293 Query: 189 SKGWLDFYK 197 + Y Sbjct: 294 DDQEIHIYD 302 Score = 88.0 bits (216), Expect = 8e-18, Method: Composition-based stats. Identities = 38/219 (17%), Positives = 72/219 (32%), Gaps = 20/219 (9%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 P+ L FSP YLA G G + I+ +++ + L + I SIA+SPD Sbjct: 104 AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY----SLDTRGKFILSIAYSPD 159 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 143 G+ L + + D I ++D++ PI + ++ Sbjct: 160 GKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPD-------------SQLLV 206 Query: 144 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 S+D + + H ++ S K + Sbjct: 207 TASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHF---VSSSSDKSVKVWDVGT 263 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 C+H+ + + + NG ++ D+ I Y+ Sbjct: 264 RTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302 >6EOJ-D nrPDB Length = 470 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 50/333 (15%), Positives = 120/333 (36%), Gaps = 34/333 (10%) Query: 16 PEKLTHTIENPLR--TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 P K TH N ++ +Q++P G L + +G +++ +F ++ AH Sbjct: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE----TLMQAHDS 136 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 +T++ +S D +++ D IK+W ++ + A Sbjct: 137 AVTTMKYSHDSDWMISGDADGMIKIW-----QPNFSMVK--------EIDAAHTESIRDM 183 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWL 193 F +D+ + S+D + + + S+ KQ H + + +I + Sbjct: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASAS---KD 240 Query: 194 DFYKFHSLYQTECIHSLKITSSNIKHLIVSQN-GERLAINCSDRTIRQYEISIDDENSAV 252 + K CI S+ + G L D++ R ++I ++ Sbjct: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR-----YSM 295 Query: 253 ELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAE 312 + + + + L+W+ I N + + +A GS H + + ++ + + Sbjct: 296 KELMCVRDETDYMTLEWHPI----NESMFTLACYDGSLKHFDLLQNL-NEPILTIPYAHD 350 Query: 313 EELIDINWDFYSMSIVSNGFESGNVYVWSVVIP 345 + + ++++ I + + + W+ P Sbjct: 351 KCITSLSYNP-VGHIFATAAKDRTIRFWTRARP 382 >4OWR-A nrPDB Length = 339 Score = 103 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 52/314 (16%), Positives = 111/314 (35%), Gaps = 27/314 (8%) Query: 31 CLQFSPC---GDYLALGCANGALVIYDM-DTFRPICVPGNMLGAHVRPITSIAWSPDGRL 86 CL FSP G++L G + +++ D+ + I M H P+ + WS DG Sbjct: 15 CLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM---HTGPVLDVCWSDDGSK 71 Query: 87 LLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDF- 145 + T+S D + K+WDLS ++ ++ + D+P+ W+ A CV T + D Sbjct: 72 VFTASCDKTAKMWDLSS-NQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTR 130 Query: 146 SNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII-VGTSKGWLDFYKFHSLYQT 204 S++P+ L Y + + I+ + + +Q Sbjct: 131 SSNPMMVLQLPERCYCADVI----YPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQH 186 Query: 205 ECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVI 264 C+ K + G A+ + + + I+ + H+ Sbjct: 187 RCVAIFKDKQN-------KPTG--FALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTN 237 Query: 265 NKLQWNCILFSNNTAEYL--VASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDF 322 + + + +T GS + W+ + T ++ E ++ + ++ Sbjct: 238 TSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSF-WDKDARTKLKTSEQLDQPISACCFN- 295 Query: 323 YSMSIVSNGFESGN 336 ++ +I + Sbjct: 296 HNGNIFAYASSYDW 309 Score = 64.5 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 44/287 (15%), Positives = 93/287 (32%), Gaps = 42/287 (14%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAW--SP 82 + + +S G + + ++D+ + + I + H P+ +I W +P Sbjct: 56 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQ-----HDAPVKTIHWIKAP 110 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 + ++T S D ++K WD S P+ ++ + + E V Sbjct: 111 NYSCVMTGSWDKTLKFWDTRS-SNPMMVLQLPERCYCADVI----YPMAVVATAERGLIV 165 Query: 143 IDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH--PNIIIVGTSKGWLDFYKFHS 200 N P S+ +++ S H + V K P +G+ +G + + + Sbjct: 166 YQLENQP-------SEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINP 218 Query: 201 LYQTECIHSLKITSSN------------IKHLIVSQNGERLAINCSDRTIRQYEISIDDE 248 + + K SN + + LA SD ++ D Sbjct: 219 PNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWD---KDA 275 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELY 295 + ++ + + N +F+ +S S HE Y Sbjct: 276 RTKLKTSEQLDQPISACCFNHNGNIFA------YASSYDWSKGHEFY 316 Score = 37.1 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 31/77 (40%), Gaps = 5/77 (6%) Query: 20 THTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIA 79 T ++ + F P LA ++G +D D + + +PI++ Sbjct: 238 TSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQL----DQPISACC 293 Query: 80 WSPDGRLLL-TSSRDWS 95 ++ +G + SS DWS Sbjct: 294 FNHNGNIFAYASSYDWS 310 >5BPW-A nrPDB Length = 843 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 39/186 (20%), Positives = 80/186 (43%), Gaps = 6/186 (3%) Query: 15 HPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI-CVPGNMLGAHVR 73 ++ + P L +SP D +AL G ++++ + +F + P N + Sbjct: 9 PSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTG--K 66 Query: 74 PITSIAWSPDGRLLLTSSRD-WSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVA 132 +T +AW PDG+LL + D I L D+ KP + L ++P+ W++ V Sbjct: 67 EVTCLAWRPDGKLLAFALADTKKIVLCDVEKP-ESLHSFSVEAPVSCMHWMEVTVESSVL 125 Query: 133 TIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGW 192 T F ++ + S+ ++ S + ++ + NI+++G S G+ Sbjct: 126 TSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVR-LNILVLGGSSGF 184 Query: 193 LDFYKF 198 ++ Y + Sbjct: 185 IELYAY 190 >3MKQ-A nrPDB Length = 814 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 34/277 (12%), Positives = 96/277 (34%), Gaps = 28/277 (10%) Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 + I + P +LT+ +++W+ + ++P+ +++ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 K + V S+D + + + +++ H + ++ Sbjct: 67 KNWIIV-------------GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL 113 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ-NGERLAINCSDRTIRQYEIS 244 G+ + + + + + + + + + + A C DRT++ + + Sbjct: 114 SGSDDLTVKLWNWEN--NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLG 171 Query: 245 IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 304 S TL + +N + + + Y++ + S + IW+ + + Sbjct: 172 ----QSTPNFTLTTGQERGVNYVDY----YPLPDKPYMITA---SDDLTIKIWDYQTKSC 220 Query: 305 VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 V LEG + + ++ I+ +G E G + +W+ Sbjct: 221 VATLEGHMSNVSFAVFHP-TLPIIISGSEDGTLKIWN 256 Score = 85.7 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 32/252 (12%), Positives = 77/252 (30%), Gaps = 20/252 (7%) Query: 17 EKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 EK+ +P + P Y+ G + + +++ + H + Sbjct: 88 EKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWE---NNWALEQTFEGHEHFVM 144 Query: 77 SIAWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLK-EIRFDSPIWGCQWLDAKRRLCVATI 134 +A++P D + D ++K+W L + + + + + Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPL--------- 195 Query: 135 FEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLD 194 Y+I S+D + + +++ H + V III G+ G L Sbjct: 196 --PDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTL- 252 Query: 195 FYKFHSLYQTECIHSLKITSSNIKHLIVSQNGE-RLAINCSDRTIRQYEISIDDENSAVE 253 K + + +L + + G + D + D+ +++ Sbjct: 253 --KIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLD 310 Query: 254 LTLEHKYQDVIN 265 + + N Sbjct: 311 PVGKLVWSGGKN 322 Score = 85.3 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 37/258 (14%), Positives = 79/258 (30%), Gaps = 15/258 (5%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 +F +++ +G + + +++ +T + AH I SIA P +L+ S Sbjct: 62 KFIARKNWIIVGSDDFRIRVFNYNTGEKVV----DFEAHPDYIRSIAVHPTKPYVLSGSD 117 Query: 93 DWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 D ++KLW+ + C + K A+ + V Sbjct: 118 DLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNF 177 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKI 212 L+ + + G V +I + + K C+ +L+ Sbjct: 178 TLT--------TGQERGVNYVDYYPLPDKPYMITASDDLTI---KIWDYQTKSCVATLEG 226 Query: 213 TSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCI 272 SN+ + + D T++ + S + + LE + + Sbjct: 227 HMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNY 286 Query: 273 LFSNNTAEYLVASTHGSS 290 + S + V S Sbjct: 287 IASGFDNGFTVLSLGNDE 304 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 23/183 (12%), Positives = 64/183 (34%), Gaps = 18/183 (9%) Query: 163 SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIV 222 + + + ++ G ++ + + + + + S+++T + ++ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVE---VRSIQVTETPVRAGKF 63 Query: 223 SQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYL 282 + + D IR + + + ++ + D I + + + Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGE-----KVVDFEAHPDYIRS-------IAVHPTKPY 111 Query: 283 VASTHGSSAHELYIWETTSG-TLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 V S GS + +W + L + EG E ++ + ++ S ++G V VWS Sbjct: 112 VLS--GSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWS 169 Query: 342 VVI 344 + Sbjct: 170 LGQ 172 >2YNP-A nrPDB Length = 604 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 35/277 (12%), Positives = 96/277 (34%), Gaps = 28/277 (10%) Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 + I + P +LT+ ++LW+ + ++P+ +++ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 K + V S+D + + + +++ H + ++ Sbjct: 67 KNWIIV-------------GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL 113 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ-NGERLAINCSDRTIRQYEIS 244 G+ + + + + + + + + + + A C DRT++ + + Sbjct: 114 SGSDDLTVKLWNWEN--NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLG 171 Query: 245 IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 304 S TL + +N + + + Y++ + S + IW+ + + Sbjct: 172 ----QSTPNFTLTTGQERGVNYVDY----YPLPDKPYMITA---SDDLTIKIWDYQTKSC 220 Query: 305 VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 V LEG + + ++ I+ +G E G + +W+ Sbjct: 221 VATLEGHMSNVSFAVFHP-TLPIIISGSEDGTLKIWN 256 Score = 84.5 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 32/252 (12%), Positives = 77/252 (30%), Gaps = 20/252 (7%) Query: 17 EKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 EK+ +P + P Y+ G + + +++ + H + Sbjct: 88 EKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWE---NNWALEQTFEGHEHFVM 144 Query: 77 SIAWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLK-EIRFDSPIWGCQWLDAKRRLCVATI 134 +A++P D + D ++K+W L + + + + + Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPL--------- 195 Query: 135 FEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLD 194 Y+I S+D + + +++ H + V III G+ G L Sbjct: 196 --PDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTL- 252 Query: 195 FYKFHSLYQTECIHSLKITSSNIKHLIVSQNGE-RLAINCSDRTIRQYEISIDDENSAVE 253 K + + +L + + G + D + D+ +++ Sbjct: 253 --KIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLD 310 Query: 254 LTLEHKYQDVIN 265 + + N Sbjct: 311 PVGKLVWSGGKN 322 Score = 84.5 bits (207), Expect = 9e-17, Method: Composition-based stats. Identities = 37/258 (14%), Positives = 79/258 (30%), Gaps = 15/258 (5%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 +F +++ +G + + +++ +T + AH I SIA P +L+ S Sbjct: 62 KFIARKNWIIVGSDDFRIRVFNYNTGEKVV----DFEAHPDYIRSIAVHPTKPYVLSGSD 117 Query: 93 DWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 D ++KLW+ + C + K A+ + V Sbjct: 118 DLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNF 177 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKI 212 L+ + + G V +I + + K C+ +L+ Sbjct: 178 TLT--------TGQERGVNYVDYYPLPDKPYMITASDDLTI---KIWDYQTKSCVATLEG 226 Query: 213 TSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCI 272 SN+ + + D T++ + S + + LE + + Sbjct: 227 HMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNY 286 Query: 273 LFSNNTAEYLVASTHGSS 290 + S + V S Sbjct: 287 IASGFDNGFTVLSLGNDE 304 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 23/183 (12%), Positives = 64/183 (34%), Gaps = 18/183 (9%) Query: 163 SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIV 222 + + + ++ G ++ + + + + + S+++T + ++ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVE---VRSIQVTETPVRAGKF 63 Query: 223 SQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYL 282 + + D IR + + + ++ + D I + + + Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGE-----KVVDFEAHPDYIRS-------IAVHPTKPY 111 Query: 283 VASTHGSSAHELYIWETTSG-TLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 V S GS + +W + L + EG E ++ + ++ S ++G V VWS Sbjct: 112 VLS--GSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWS 169 Query: 342 VVI 344 + Sbjct: 170 LGQ 172 >5WYJ-BC nrPDB Length = 817 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 41/287 (14%), Positives = 97/287 (33%), Gaps = 26/287 (9%) Query: 61 ICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPL----KEIRFDSP 116 + + + H + S+ + DG + T+S+D + +W ++ S K I + Sbjct: 377 LPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAA 436 Query: 117 IWGC---QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV 173 + + + T + P AS+ + + + H + Sbjct: 437 VTAVGLPNIVSKGYPEFLLTASNDLTIKKW-IIPKPTASMDVQIIKVSEYTRHAHEKDIN 495 Query: 174 CTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINC 233 + + +I + + K +L E +L + + Q + LA + Sbjct: 496 ALSVSPNDSIFATAS---YDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSS 552 Query: 234 SDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHE 293 D+T++ + + D S ++ H + + F N + + G Sbjct: 553 GDKTVKIWSL---DTFSVMKTLEGHTN--AVQR-----CSFINKQKQLISCGADG----L 598 Query: 294 LYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 + IW+ +SG ++ L+G L ++ ++ + G W Sbjct: 599 IKIWDCSSGECLKTLDGHNNRLWALS-TMNDGDMIVSADADGVFQFW 644 Score = 94.2 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 37/250 (14%), Positives = 82/250 (32%), Gaps = 28/250 (11%) Query: 39 DYLALGCANGALVIYDMDT------FRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 ++L + + + + + I V AH + I +++ SP+ + T+S Sbjct: 452 EFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASY 511 Query: 93 DWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 D + K+W+L +W F + D + S D Sbjct: 512 DKTCKIWNLENGELEATLANHKRGLWDV-------------SFCQYDKLLATSSGDKTVK 558 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKI 212 + S + + H + +I + G K EC+ +L Sbjct: 559 IWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADG---LIKIWDCSSGECLKTLDG 615 Query: 213 TSSNIKHLIVSQNGERLAINCSDRTIRQY------EISIDDENSAVELTLEHKYQDVINK 266 ++ + L +G+ + +D + + EI + E + +++ E Q+ ++K Sbjct: 616 HNNRLWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQSLQNYMSK 675 Query: 267 LQWNCILFSN 276 W Sbjct: 676 GDWTNAFLLA 685 Score = 90.7 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 37/280 (13%), Positives = 90/280 (32%), Gaps = 30/280 (10%) Query: 14 EHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 E E L ++++ G ++A + +++ + H Sbjct: 385 EGHEDLLNSLDATE---------DGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSA 435 Query: 74 PITSIAW-----SPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRR 128 +T++ LLT+S D +IK W + KP+ + + A + Sbjct: 436 AVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRH---AHEK 492 Query: 129 LCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGT 188 A +D+ S D + + + + ++ +H L ++ ++ + Sbjct: 493 DINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSS 552 Query: 189 SKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDE 248 + K SL + +L+ ++ ++ ++L +D I+ ++ Sbjct: 553 GDKTV---KIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWD---CSS 606 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHG 288 ++ D N W N+ + A G Sbjct: 607 GECLKTL------DGHNNRLWALSTM-NDGDMIVSADADG 639 Score = 85.7 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 33/229 (14%), Positives = 74/229 (32%), Gaps = 27/229 (11%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 + L SP A + I++++ L H R + +++ Sbjct: 489 AHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEA----TLANHKRGLWDVSFCQY 544 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 143 +LL TSS D ++K+W L S + + C +++ +++L Sbjct: 545 DKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGA--------- 595 Query: 144 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 D + + S + L + H L ++I+ + G F+K + + Sbjct: 596 ----DGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKDCTEQE 651 Query: 204 TEC--------IHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 244 E + + + + + L D +R + + Sbjct: 652 IEEEQEKAKLQVEQEQSLQNYMSKGDWTN--AFLLAMTLDHPMRLFNVL 698 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 46/291 (15%), Positives = 104/291 (35%), Gaps = 32/291 (10%) Query: 35 SPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDW 94 S G LA + + I D+ T + + + IT++ +PDG+ L S+ Sbjct: 26 SENGKILATPVLD-EINIIDL-TPGSRKILHKISNEDEQEITALKLTPDGQYLTYVSQAQ 83 Query: 95 SIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLL 154 +K++ L K K ++ ++ SP + + + + D ++ Sbjct: 84 LLKIFHL-KTGKVVRSMKISSPSYILD-------------ADSTSTLLAVGGTDGSIIVV 129 Query: 155 SKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLD-FYKFHSLYQTECIHSLKIT 213 + S HG + N I + G + K L + +C+H+L+ Sbjct: 130 DIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEH 189 Query: 214 SSNIKHLIV------SQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKL 267 +S ++ L + + L D I ++ ++ + +N+ Sbjct: 190 TSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWD-------FNMKKKCKLLKTLPVNQQ 242 Query: 268 QWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDI 318 +C + + ++ + G + ++ SG++++ EEL I Sbjct: 243 VESCGFLKDGDGKRIIYTAGG--DAIFQLIDSESGSVLKRTNKPIEELFII 291 Score = 51.0 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 34/220 (15%), Positives = 67/220 (30%), Gaps = 20/220 (9%) Query: 131 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGY-VLVCTVHTKHPNIIIVGTS 189 VAT+ E ++ L+ K L + + T + T Sbjct: 22 VATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYL---TY 78 Query: 190 KGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDEN 249 K L + + S+KI SS L LA+ +D +I +I + Sbjct: 79 VSQAQLLKIFHLKTGKVVRSMKI-SSPSYILDADSTSTLLAVGGTDGSIIVVDI---ENG 134 Query: 250 SAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLE 309 H K N+ +L+AS G + + +W+ + L+ Sbjct: 135 YITHSFKGHGGTISSLKFYGQL-----NSKIWLLAS--GDTNGMVKVWDLVKRKCLHTLQ 187 Query: 310 GAEEEL-----IDINWDFYSMSIVSNGFESGNVYVWSVVI 344 + I++ + + +G + +W + Sbjct: 188 EHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNM 227 >5XYI-g nrPDB Length = 335 Score = 99.2 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 40/284 (14%), Positives = 89/284 (31%), Gaps = 23/284 (8%) Query: 19 LTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSI 78 T I + + S +L + L ++D+ T + H + + + Sbjct: 73 FTRLIGHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTT----KKLFLGHKKDVLGV 128 Query: 79 AWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEES 138 +SP R +++ RD +K+W++ + E++ S + C E S Sbjct: 129 TFSPCNRRIISVGRDNQVKIWNI--LGENKAELQCSSWVTSVA--------CAPMADETS 178 Query: 139 DAYVIDFSNDPVASLLSKSDEKQLSS-TPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 + D + S E +L H T +I G S + + Sbjct: 179 PLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWL 238 Query: 198 FHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLE 257 + +T S + + + + ++I + V+ + Sbjct: 239 TENGAKT----ISFTAPSPVHAVAACPTQAWICAATYEGIA-VWDIGAKQQIDLVQPNFK 293 Query: 258 HKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTS 301 H+ + + +C + ++ S G + + WE S Sbjct: 294 HEGKRNAGRTP-DCTCLAWAADGSVLYS--GYNDGSIRAWEVKS 334 Score = 97.6 bits (241), Expect = 9e-21, Method: Composition-based stats. Identities = 50/332 (15%), Positives = 106/332 (31%), Gaps = 41/332 (12%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI-CVPGNMLGAHVRPITSIAWS 81 + + E ++ +YL + + +++ ++ + P L H ++ ++ S Sbjct: 30 VGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLS 89 Query: 82 PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 D LLTSS D +++LWDLS + + + G + RR+ + + Sbjct: 90 RDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIW 149 Query: 142 VIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSL 201 I N S + D LV I VG G + + Sbjct: 150 NILGENKAELQCSSWVTSVACAPMADETSPLV----------IAVGCWDGKVYIWSIE-- 197 Query: 202 YQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQ 261 + + I K + + +G+ + SDR + + + + Sbjct: 198 KEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPSPVHAV 257 Query: 262 DVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLE-----------G 310 W C A+ G + +W+ + + +++ G Sbjct: 258 AACPTQAWICA-----------ATYEG-----IAVWDIGAKQQIDLVQPNFKHEGKRNAG 301 Query: 311 AEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 + + W + S G+ G++ W V Sbjct: 302 RTPDCTCLAWAADGSVLYS-GYNDGSIRAWEV 332 >5L9T-R nrPDB Length = 493 Score = 98.8 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 40/227 (17%), Positives = 81/227 (35%), Gaps = 18/227 (7%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 KL+ + R L ++ + L+ G + ++ D+ T P L H + + Sbjct: 263 KLSMLEGHTARVGALAWN--AEQLSSGSRDRMILQRDIRT--PPLQSERRLQGHRQEVCG 318 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 + WS D +LL + D + +W+ S S + + + W + L + Sbjct: 319 LKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGG--- 375 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV-GTSKGWLDFY 196 + D + + L V ++ G S+ + + Sbjct: 376 -------GTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVW 428 Query: 197 KFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 K+ SL Q + L S + +L +S +GE + D T+R + + Sbjct: 429 KYPSLTQ---VAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 81.1 bits (198), Expect = 9e-16, Method: Composition-based stats. Identities = 43/298 (14%), Positives = 92/298 (30%), Gaps = 39/298 (13%) Query: 50 LVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLK 109 + ++ T + + + +TS+ WS G L+ + +++WD + K Sbjct: 209 VYLWSACTSQVTRLCDLSVEG--DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSM 266 Query: 110 EIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDE--KQLSSTPD 167 + + W + + S D + + Sbjct: 267 LEGHTARVGALAW---------------NAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 311 Query: 168 HGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGE 227 H + + ++ G + L + SL + + +K + S + Sbjct: 312 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSL---SPVQQYTEHLAAVKAIAWSPHQH 368 Query: 228 RLAI---NCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVA 284 L +DR IR + ++ + L W S + E + Sbjct: 369 GLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVC------NLAW-----SKHANELV-- 415 Query: 285 STHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 STHG S +++ +W+ S T V L G ++ + + G + W+V Sbjct: 416 STHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSP-DGEAIVTGAGDETLRFWNV 472 Score = 48.3 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 17/95 (17%), Positives = 41/95 (43%), Gaps = 6/95 (6%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLAL--GCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 + I+ + L +S + L G + ++++ + + L H + Sbjct: 391 QPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVA----KLTGHSYRV 446 Query: 76 TSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKE 110 +A SPDG ++T + D +++ W++ ++ KE Sbjct: 447 LYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKE 481 Score = 31.0 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 7/44 (15%), Positives = 17/44 (38%) Query: 17 EKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRP 60 ++ + R L SP G+ + G + L +++ + Sbjct: 434 TQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTR 477 >6J6H-n nrPDB Length = 455 Score = 96.8 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 52/337 (15%), Positives = 112/337 (33%), Gaps = 35/337 (10%) Query: 6 QDPFAVLKEHPEKLTHTIENPLRTECLQFSPC-GDYLALGCANGALVIYDMDTFRPICVP 64 P V++ +P +P T L+F P G + G + + I+D Sbjct: 149 YLPKKVIRNYP-------GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL-- 199 Query: 65 GNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLD 124 H +PI ++ ++ D + L+SS D S+K+WD ++ K + +S + Sbjct: 200 -RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD-TETGKVKTRLHLNSTPADVESRP 257 Query: 125 AKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNII 184 + + I +D V+ ++ + + H ++ + + Sbjct: 258 TNPHEFIVGLSNSK----ILHYDDRVS-----ENQGLVQTYDHHLSSILALKYFPDGSKF 308 Query: 185 IVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 244 I + + + + ++ L V + D I + + Sbjct: 309 ISSSEDKTVRIW--ENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK 366 Query: 245 IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 304 + ++ H L FS + Y+ G S L+ W+ + L Sbjct: 367 PKYKRHPKKIFKGHSSAGYGISLA-----FSGD-GRYI---CSGDSKSRLFTWDWNTSRL 417 Query: 305 VR--VLEGAEEELIDINWDFYSMSIVSNGFESGNVYV 339 + + G + + ++W S V +G +YV Sbjct: 418 LNNIKIPG-NKPITQVDWHPQETSKVICSGAAGKIYV 453 Score = 48.7 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 25/179 (13%), Positives = 51/179 (28%), Gaps = 14/179 (7%) Query: 22 TIENPLRT-ECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAW 80 T ++ L + L++ P G + + I++ PI + H P ++ Sbjct: 288 TYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ-HSMPFLNVH- 345 Query: 81 SPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDA 140 P S D I S K R I+ ++ F Sbjct: 346 -PSQNYFCAQSMDNRI-----YSFSLKPKYKRHPKKIFKGHSSAGYG---ISLAFSGDGR 396 Query: 141 YVIDFSNDPVASLLSKSDEKQL--SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 Y+ + + + L P + + H + + +I + G + Sbjct: 397 YICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 Score = 32.1 bits (71), Expect = 0.42, Method: Composition-based stats. Identities = 5/40 (12%), Positives = 15/40 (37%) Query: 302 GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 ++R G E + + + ++ +G + +W Sbjct: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWD 191 >5WYJ-BE nrPDB Length = 939 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 80/210 (38%), Gaps = 23/210 (10%) Query: 22 TIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS 81 T ++ + + S CG++ +G +NG++ IY+M + + H R +T I+ Sbjct: 457 TTDDG-FVKSVAMSQCGNFGFIGSSNGSITIYNMQSG----ILRKKYKLHKRAVTGISLD 511 Query: 82 PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 R +++ D + +D +K S L +++ D+PI + + A ++ Sbjct: 512 GMNRKMVSCGLDGIVGFYDFNK-STLLGKLKLDAPITAMVYH--RSSDLFALALDDLSIV 568 Query: 142 VIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSL 201 VID V L H + + I+ + + + L Sbjct: 569 VIDAVTQRVVRQL-----------WGHSNRITAFDFSPEGRWIVSASLDSTI---RTWDL 614 Query: 202 YQTECIHSLKITSSNIKHLIVSQNGERLAI 231 CI + I + ++ S NG+ LA Sbjct: 615 PTGGCIDGI-IVDNVATNVKFSPNGDLLAT 643 Score = 69.9 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 38/325 (11%), Positives = 97/325 (29%), Gaps = 41/325 (12%) Query: 40 YLALGCANGALVIYDMD------TFRPICVPGNML---GAHVRPITSIAWSPD-GRLLLT 89 + + +L Y D + + P L G H +P + IA++ +L+ Sbjct: 309 IIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLS 368 Query: 90 SSRDWSIKLWDLSKP------SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE----ESD 139 +S+D S+ + L K S+ L + + + G + I E + Sbjct: 369 ASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWE 428 Query: 140 AYVIDFSNDPVASLLSKSDEKQLSSTPDHGYV--LVCTVHTKHPNIIIVGTSKGWLDFYK 197 + ++ A +++ T D + ++ N +G+S G + Y Sbjct: 429 NIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYN 488 Query: 198 FHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLE 257 K+ + + + ++ D + Y+ + ++L Sbjct: 489 M---QSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAP 545 Query: 258 HKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELID 317 + + + + + + + +VR L G + Sbjct: 546 ITAMVYHRSS--DLFALALD-------------DLSIVVIDAVTQRVVRQLWGHSNRITA 590 Query: 318 INWDFYSMSIVSNGFESGNVYVWSV 342 ++ + + + W + Sbjct: 591 FDFSPEG-RWIVSASLDSTIRTWDL 614 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 32/245 (13%), Positives = 64/245 (26%), Gaps = 33/245 (13%) Query: 53 YDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIR 112 +DM R + + S+A S G S + SI ++++ K Sbjct: 443 WDMRNKRVGRWTFDTTD--DGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKL 500 Query: 113 FDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVL 172 + G R++ + D + + L + Sbjct: 501 HKRAVTGISLDGMNRKMVSCGL-------------DGIVGFYDFNKSTLLGKLK-LDAPI 546 Query: 173 VCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAIN 232 V+ + ++ + + + L S+ I S G + Sbjct: 547 TAMVYHRSSDLFALALDDLSIVVI---DAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSA 603 Query: 233 CSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAH 292 D TIR +++ +I + FS N G+ Sbjct: 604 SLDSTIRTWDL-----------PTGGCIDGIIVDNVATNVKFSPNGDLLATTHVTGNG-- 650 Query: 293 ELYIW 297 + IW Sbjct: 651 -ICIW 654 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 25/118 (21%), Positives = 46/118 (38%), Gaps = 6/118 (5%) Query: 27 LRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRL 86 + + D AL + ++V+ D T R + L H IT+ +SP+GR Sbjct: 544 APITAMVYHRSSDLFALALDDLSIVVIDAVTQRVV----RQLWGHSNRITAFDFSPEGRW 599 Query: 87 LLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 ++++S D +I+ WDL I D+ ++ L T + + Sbjct: 600 IVSASLDSTIRTWDLPTGGCIDGII-VDNVATNVKFSPNG-DLLATTHVTGNGICIWT 655 >5OQL-J nrPDB Length = 912 Score = 96.5 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 46/243 (18%), Positives = 82/243 (33%), Gaps = 19/243 (7%) Query: 10 AVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDM----DTFRPICVPG 65 A+ K P + +NPL P +L G + + D+ + Sbjct: 486 ALPKVVPPANSEAFKNPLD------HPPA-FLISGSQDRFVQKRDIPRQLQKGGKLTSSL 538 Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 L AH + I ++ SP+G+L ++S+D ++K+WD+ K +W ++ Sbjct: 539 RRL-AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPL 597 Query: 126 KRRLCVATI-FEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTV--HTKHPN 182 + V+ S D L + SD + + H + ++ V H + Sbjct: 598 NTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDD 657 Query: 183 IIIVGT----SKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTI 238 I S G K E +L + L V LA SD + Sbjct: 658 SITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKV 717 Query: 239 RQY 241 + Sbjct: 718 TFW 720 Score = 91.1 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 40/315 (12%), Positives = 95/315 (30%), Gaps = 37/315 (11%) Query: 54 DMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI-- 111 + + +L H + S+ G + + S+D + +LW + + Sbjct: 415 ECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAV 474 Query: 112 --RFDSPIWGCQ---WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSD-----EKQ 161 + + + A++I S D K Sbjct: 475 FTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKL 534 Query: 162 LSSTP--DHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKH 219 SS H + + + + + + K + + E L+ + Sbjct: 535 TSSLRRLAHDKDINALDISPNGKLFASASQDKTV---KIWDVEKLEVQGILRGHKRGVWT 591 Query: 220 LIVSQ------NGER--------LAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVIN 265 + + GE+ + D+TI+ + +S + + + H + + Sbjct: 592 VRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLS---DYTCIRTFEGHSH--NVL 646 Query: 266 KLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSM 325 K+ W I ++ + V + + +W+ +G L+ E+ L + + Sbjct: 647 KVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTN 706 Query: 326 SIVSNGFESGNVYVW 340 + S G +S V W Sbjct: 707 ILASAGSDS-KVTFW 720 Score = 88.0 bits (216), Expect = 8e-18, Method: Composition-based stats. Identities = 52/356 (14%), Positives = 104/356 (29%), Gaps = 51/356 (14%) Query: 36 PCGDYLALGCANGALVIYDM--------DTFRPICVPGNMLGAHVRPITSIAW-SPDGRL 86 P + A+ LV+Y + + + P + I + + PD + Sbjct: 329 PERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSM 388 Query: 87 --LLTSSRD-WSIKLWDLSKPSKPLKEIRFDSPIW-GCQWLDAKRRLCVATIFEESDAYV 142 + T+S D + + D S+ E R S L + ++ + S ++ Sbjct: 389 MAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWI 448 Query: 143 IDFSNDPVASLLSKS----DEKQLSSTPDHGYVLVCTVHTKH----------------PN 182 S D A L + H + K P Sbjct: 449 ASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPA 508 Query: 183 IIIVGTSKGWL--DFYKFHSLYQTECIHSLK--ITSSNIKHLIVSQNGERLAINCSDRTI 238 +I G+ ++ + SL+ +I L +S NG+ A D+T+ Sbjct: 509 FLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTV 568 Query: 239 RQYEISIDDENSAVELTLEHKYQDVINKL-QWNCILFSNNTAEYLVAST--HGSSAHELY 295 + +++ + + HK + N + GS + Sbjct: 569 KIWDVEKLEVQG---ILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIK 625 Query: 296 IWETTSGTLVRVLEGAEEELIDINW--------DFYSMSIVSNGFESGNVYVWSVV 343 +W + T +R EG ++ + W + ++ V VW Sbjct: 626 LWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDAN 681 Score = 78.7 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 53/385 (13%), Positives = 109/385 (28%), Gaps = 90/385 (23%) Query: 40 YLALGCANGALVIYDMDTFRPICV---PGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSI 96 LA G +G + I+D+ V P AH + IA+SP+ LL+ SRD ++ Sbjct: 197 RLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTM 256 Query: 97 KLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFS--NDPVASLL 154 LW + + +L+ + + A + D + ++ Sbjct: 257 TLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTS--GVLRIWDTTTHHEITKKQD 314 Query: 155 SKSDEKQL---------------------------------------------SSTPDHG 169 +KS+ + + + H Sbjct: 315 AKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHD 374 Query: 170 YVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLY-----QTEC---------IHSLKITSS 215 +L T +++ + T+ + EC + LK Sbjct: 375 EILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHED 434 Query: 216 NIKHLIVSQNGERLAINCSDRTIRQYEISIDDENS-AVELTLEHKYQDVINKLQW----- 269 + L V +G +A D T R + + + + + H L Sbjct: 435 IVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPA 494 Query: 270 NCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLE------------GAEEELID 317 N F N GS + + R L+ ++++ Sbjct: 495 NSEAFKNPLDHPPAFLISGSQDRFV-----QKRDIPRQLQKGGKLTSSLRRLAHDKDINA 549 Query: 318 INWDFYSMSIVSNGFESGNVYVWSV 342 ++ + + ++ + V +W V Sbjct: 550 LDISP-NGKLFASASQDKTVKIWDV 573 Score = 69.1 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 52/378 (13%), Positives = 109/378 (28%), Gaps = 67/378 (17%) Query: 16 PEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTF----RPICVPGNMLGAH 71 P + T + L LA G A+GA+ I+D+ + H Sbjct: 101 PTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALH 160 Query: 72 VRPITSIAWSPDGRL----------------------LLTSSRDWSIKLWDLSKPSK--- 106 I A S L ++D I+++DL K + Sbjct: 161 FFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPV 220 Query: 107 ----PLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQL 162 K+ +S + + + L S D +L D Sbjct: 221 YADPKRKKEAHESNVQCIAYSPEQHALL-------------SGSRDKTMTLWLWRDGIWQ 267 Query: 163 SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIV 222 + +L + + G L + + ++ K I + Sbjct: 268 GTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVS 327 Query: 223 SQNGERLAINCSDRTIRQYEI-SIDDENSAVELTLEHKYQ--DVINKLQWNCILFSNNTA 279 + +D T+ Y + S D S+ E L ++ + + + + Sbjct: 328 LPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQS 387 Query: 280 EYLVASTHGS----SAHELYIWETTSGTL---------VRVLEGAEEEL--IDINWDFYS 324 +A+ S + + + V +L+G E+ + +D++W + Sbjct: 388 MMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGH- 446 Query: 325 MSIVSNGFESGNVYVWSV 342 +++G + +W V Sbjct: 447 --WIASGSKDNTARLWRV 462 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 47/345 (13%), Positives = 108/345 (31%), Gaps = 59/345 (17%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSI 96 G + ++ +++T + + + PI+++ +P G L+ SR ++ Sbjct: 30 NGARILASTLGENAILTELNTGKRLAE----IQGDGEPISTLTITPSGSHLIVCSRSLTM 85 Query: 97 KL--------WDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 148 ++ +D +P+ +P+ + +AT + + D Sbjct: 86 RIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAV--DRTSTLLATGAADGAIKIWDIIGG 143 Query: 149 PVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNI----------------------IIV 186 V +S + + H + + T ++ N + Sbjct: 144 YVTHTVSGPS---VLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAW 200 Query: 187 GTSKGWLDFYKFHSLYQT----ECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 GT G + + + T + + SN++ + S L D+T+ + Sbjct: 201 GTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWL 260 Query: 243 ISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSG 302 L H+ + + L ++S T+ L IW+TT+ Sbjct: 261 WRDGIWQGT--PMLRHELLESVGFLNEGKWMYSAGTSGV------------LRIWDTTTH 306 Query: 303 TLVRVLEGA--EEELIDINWDFYSMSIVSNGFESGNVYVWSVVIP 345 + + A E E I S++ + ++ V P Sbjct: 307 HEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSP 351 Score = 50.2 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 78/232 (33%), Gaps = 29/232 (12%) Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY 196 E+ A ++ + A L + K+L+ G + T + +IV + + Y Sbjct: 29 ENGARILASTLGENAILTELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIY 88 Query: 197 KF-----HSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISI-----D 246 + + + + K ++ + L V + LA +D I+ ++I Sbjct: 89 SLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHT 148 Query: 247 DENSAVELTLEHKYQDVI-------NKLQWNCILFSNNTAEYLVAS----THGSSAHELY 295 +V ++ H ++ + NK N +AS G+ + Sbjct: 149 VSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIR 208 Query: 296 IWETTSGTLVRVL-------EGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 I++ T V E E + I + +++S G + +W Sbjct: 209 IFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLS-GSRDKTMTLW 259 >5OQL-L nrPDB Length = 557 Score = 95.3 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 34/235 (14%), Positives = 72/235 (30%), Gaps = 18/235 (7%) Query: 9 FAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNML 68 F++ K P K ++ C + P G L G G + ++D+ V Sbjct: 84 FSIRKREPLKTIGRFDS--EAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTR-AVILKTW 140 Query: 69 GAHVRPITSIAWSPDG-RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKR 127 H +P+ WSP L++ S D +++LWDL + ++ Sbjct: 141 HIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSA 200 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVG 187 ++ S D + T H + + ++ Sbjct: 201 NS----------NLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAA 250 Query: 188 TSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 + + L + + + + L ++ G R+ D ++ +E Sbjct: 251 SG----NAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFE 301 Score = 78.4 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 47/309 (15%), Positives = 100/309 (32%), Gaps = 45/309 (14%) Query: 41 LALGCANGALVIYDMDTFRPICVPGN-MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 L A + I+ + P+ G AH I PDGR+L+ ++++ Sbjct: 72 LFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEI-----RPDGRVLVAGEDTGRMQVF 126 Query: 100 DLSKPSKPLKEIR---FDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSK 156 D+ + ++ + P+W +W + ++ S+D L Sbjct: 127 DVGQGTRAVILKTWHIHKQPVWVTKWSPTEL------------TTLMSCSDDKTVRLWDL 174 Query: 157 SDEKQLSSTPDHGYVLVCTVHTK---HPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKIT 213 H + C + N+++ G+ + + + + K Sbjct: 175 PSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDAR--APGGAVMTFK-H 231 Query: 214 SSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCIL 273 + I+ ++ +G L S I ++ L L +Q + L Sbjct: 232 ADPIEDVLPLPSGTTLL-AASGNAISVLDLVAAKP-----LRLITNHQKTVTSLS----- 280 Query: 274 FSNNTAEYLVASTHGSSAHELYIWETTSGTLV--RVLEGAEEELIDI-NWDFYSMSIVSN 330 + +V+ GS + ++ETTS +V L I + ++ Sbjct: 281 -LASQGRRVVS---GSLDGHVKVFETTSWNVVAGAKYPSPILSLSVITAGASHDDRHLAV 336 Query: 331 GFESGNVYV 339 G +SG + + Sbjct: 337 GMQSGVLSI 345 Score = 75.7 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 28/172 (16%), Positives = 59/172 (34%), Gaps = 22/172 (12%) Query: 33 QFSPC-GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAW---SPDGRLLL 88 ++SP L + + ++D+ + P + H + A+ S + LL+ Sbjct: 151 KWSPTELTTLMSCSDDKTVRLWDLPSNDP----TRLFTGHTDYVRCGAFMPGSANSNLLV 206 Query: 89 TSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 148 + S D ++++WD P + + PI L + L A+ Sbjct: 207 SGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAAS--------------G 252 Query: 149 PVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHS 200 S+L K L +H + ++ G+ G + ++ S Sbjct: 253 NAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTS 304 Score = 34.4 bits (77), Expect = 0.086, Method: Composition-based stats. Identities = 16/152 (10%), Positives = 50/152 (32%), Gaps = 8/152 (5%) Query: 197 KFHSLYQTECIHSLKITSSNIKHLIVSQN--GERLAINCSDRTIRQYEISIDDENSAVEL 254 ++ ++ + H+ + I H+ + L + + ++ VE+ Sbjct: 25 RYWRSFKKQKSHT-STANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEI 83 Query: 255 TLEHKYQ--DVINKL--QWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEG 310 K + I + + +C + LVA + + T +++ Sbjct: 84 FSIRKREPLKTIGRFDSEAHCGEIRPD-GRVLVAGEDTGRMQVFDVGQGTRAVILKTWHI 142 Query: 311 AEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 ++ + W ++ + + + V +W + Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDL 174 >5G04-R nrPDB Length = 499 Score = 95.3 bits (235), Expect = 5e-20, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 88/244 (36%), Gaps = 23/244 (9%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 +L + + R L ++ L+ G +G + +D+ R L H + + Sbjct: 260 RLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDV---RVAEHHVATLSGHSQEVCG 314 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPS---KPLKEI-RFDSPIWGCQWLDAKRRLCVAT 133 + W+PDGR L + D + +W + PL+ + + W + + Sbjct: 315 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 374 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV-GTSKGW 192 ++D + + LS+ H V + +I G ++ Sbjct: 375 G----------GTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 424 Query: 193 LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAV 252 L +K+ ++ + + LK +S + L +S +G +A +D T+R + D Sbjct: 425 LVIWKYPTMAK---VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 481 Query: 253 ELTL 256 E Sbjct: 482 EREK 485 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 38/332 (11%), Positives = 101/332 (30%), Gaps = 40/332 (12%) Query: 16 PEKLTHT--IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 P+++ I N + +S G+ LA+ + ++ ++ + + + Sbjct: 172 PDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPG--E 227 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 I+S+AW +G L + ++LWD+ + + + + W Sbjct: 228 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW----------- 276 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEK-QLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGW 192 + + S + +++ H + + G + Sbjct: 277 ----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 332 Query: 193 LDFYKFHSLYQT-ECIHSLKITSSNIKHLIVSQNGERLAI---NCSDRTIRQYEISIDDE 248 ++ + + + +K + + SDR IR + + Sbjct: 333 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS--- 389 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL 308 + + H + + S HG + ++L IW+ + V L Sbjct: 390 GACLSAVDAHS----------QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL 439 Query: 309 EGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 +G ++ + + V++ + +W Sbjct: 440 KGHTSRVLSLTMSPDGAT-VASAAADETLRLW 470 >5BPT-A nrPDB Length = 741 Score = 94.5 bits (233), Expect = 7e-20, Method: Composition-based stats. Identities = 38/186 (20%), Positives = 76/186 (40%), Gaps = 6/186 (3%) Query: 15 HPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI-CVPGNMLGAHVR 73 P + + P L +SP D +AL G ++++ + + + +P N + Sbjct: 2 PPFRQVGEKQLPHEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTG--K 59 Query: 74 PITSIAWSPDGRLLLTSSRD-WSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVA 132 +T +AW PDG++L D + L D+ KP + L ++PI QW++ V Sbjct: 60 EVTCLAWRPDGKILAFGLADTKKVILCDVEKP-ESLHSFSLETPISCMQWMEVNVENSVL 118 Query: 133 TIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGW 192 T F ++ A + + ++ S +L + N +++G G Sbjct: 119 TSFYNAEDEANVLLPKLPALPKNYTATAKIFSEEKSDEILKLLGDAR-LNALVLGGDSGQ 177 Query: 193 LDFYKF 198 ++ Y + Sbjct: 178 IEIYAY 183 >4GGA-A nrPDB Length = 420 Score = 94.2 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 88/244 (36%), Gaps = 23/244 (9%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 +L + + R L ++ L+ G +G + +D+ R L H + + Sbjct: 181 RLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDV---RVAEHHVATLSGHSQEVCG 235 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPS---KPLKEI-RFDSPIWGCQWLDAKRRLCVAT 133 + W+PDGR L + D + +W + PL+ + + W + + Sbjct: 236 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 295 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV-GTSKGW 192 ++D + + LS+ H V + +I G ++ Sbjct: 296 G----------GTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 345 Query: 193 LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAV 252 L +K+ ++ + + LK +S + L +S +G +A +D T+R + D Sbjct: 346 LVIWKYPTMAK---VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 402 Query: 253 ELTL 256 E Sbjct: 403 EREK 406 Score = 86.1 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 38/332 (11%), Positives = 101/332 (30%), Gaps = 40/332 (12%) Query: 16 PEKLTHT--IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 P+++ I N + +S G+ LA+ + ++ ++ + + + Sbjct: 93 PDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPG--E 148 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 I+S+AW +G L + ++LWD+ + + + + W Sbjct: 149 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW----------- 197 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEK-QLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGW 192 + + S + +++ H + + G + Sbjct: 198 ----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 253 Query: 193 LDFYKFHSLYQT-ECIHSLKITSSNIKHLIVSQNGERLAI---NCSDRTIRQYEISIDDE 248 ++ + + + +K + + SDR IR + + Sbjct: 254 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS--- 310 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL 308 + + H + + S HG + ++L IW+ + V L Sbjct: 311 GACLSAVDAHS----------QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL 360 Query: 309 EGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 +G ++ + + V++ + +W Sbjct: 361 KGHTSRVLSLTMSPDGAT-VASAAADETLRLW 391 >5LCW-Q nrPDB Length = 374 Score = 93.8 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 88/244 (36%), Gaps = 23/244 (9%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 +L + + R L ++ L+ G +G + +D+ R L H + + Sbjct: 135 RLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDV---RVAEHHVATLSGHSQEVCG 189 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPS---KPLKEI-RFDSPIWGCQWLDAKRRLCVAT 133 + W+PDGR L + D + +W + PL+ + + W + + Sbjct: 190 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 249 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV-GTSKGW 192 ++D + + LS+ H V + +I G ++ Sbjct: 250 G----------GTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 299 Query: 193 LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAV 252 L +K+ ++ + + LK +S + L +S +G +A +D T+R + D Sbjct: 300 LVIWKYPTMAK---VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRR 356 Query: 253 ELTL 256 E Sbjct: 357 EREK 360 Score = 85.7 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 38/332 (11%), Positives = 101/332 (30%), Gaps = 40/332 (12%) Query: 16 PEKLTHT--IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 P+++ I N + +S G+ LA+ + ++ ++ + + + Sbjct: 47 PDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPG--E 102 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 I+S+AW +G L + ++LWD+ + + + + W Sbjct: 103 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW----------- 151 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEK-QLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGW 192 + + S + +++ H + + G + Sbjct: 152 ----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 207 Query: 193 LDFYKFHSLYQT-ECIHSLKITSSNIKHLIVSQNGERLAI---NCSDRTIRQYEISIDDE 248 ++ + + + +K + + SDR IR + + Sbjct: 208 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS--- 264 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL 308 + + H + + S HG + ++L IW+ + V L Sbjct: 265 GACLSAVDAHS----------QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL 314 Query: 309 EGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 +G ++ + + V++ + +W Sbjct: 315 KGHTSRVLSLTMSPDGAT-VASAAADETLRLW 345 >4L9O-A nrPDB Length = 349 Score = 93.8 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 36/269 (13%), Positives = 89/269 (33%), Gaps = 23/269 (8%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS--PDGRLLLTSSRDW 94 G LA ++ + I+++D V L H P+ +AW+ G +L + S D Sbjct: 80 YGRRLATCSSDKTIKIFEIDGENQRLV--ETLIGHEGPVWQVAWAHPKFGVILASCSYDG 137 Query: 95 SIKLW--DLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 + +W D +K + + + W + + + +++F + Sbjct: 138 KVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALE 197 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHS-LK 211 + + + + G + +++ +T + Sbjct: 198 PIVIQGHA----IGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQ 253 Query: 212 ITSSNIKHLIVSQN---GERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQ 268 S ++ + S + +A DRT+ + + + K+ DV Sbjct: 254 GHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDV----- 308 Query: 269 WNCILFSNNTAEYLVASTHGSSAHELYIW 297 C S + + ++A + G +++ +W Sbjct: 309 --CWRASWSLSGNVLAISGG--DNKVTLW 333 Score = 79.1 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 43/294 (14%), Positives = 98/294 (33%), Gaps = 30/294 (10%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPL--KEIRFDSPIWGCQWLDAKR 127 AH I GR L T S D +IK++++ ++ L I + P+W W K Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKF 126 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH--PNIII 185 + +A+ + + + + +++ H + H +++ Sbjct: 127 GVILASCSYDGKVLIW----KEDNGVWN-----KVAEHSVHQASVNSVSWAPHEYGPVLL 177 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ-----NGERLAINCSDRTIRQ 240 +S G + +F E I ++ + + + N R D ++ Sbjct: 178 CASSDGKISIVEFKDGGALEPI-VIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKI 236 Query: 241 YEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET- 299 + + A + +E + + + + ++ +A+ S + IW Sbjct: 237 WRY-----DDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATA--SQDRTVLIWTKD 289 Query: 300 TSGTLVRVLEGAEEELIDINWDFY---SMSIVSNGFESGNVYVWSVVIPPKWSA 350 +E+ D+ W S ++++ V +W I KW + Sbjct: 290 GKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENIQGKWES 343 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 42/125 (33%), Gaps = 13/125 (10%) Query: 25 NPLRTECLQFSPCG-----DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIA 79 + + ++P G + + I+ D + H + +A Sbjct: 204 HAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVA 263 Query: 80 WSP---DGRLLLTSSRDWSIKLW--DLSK---PSKPLKEIRFDSPIWGCQWLDAKRRLCV 131 WSP + T+S+D ++ +W D +PL + +F W W + L + Sbjct: 264 WSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAI 323 Query: 132 ATIFE 136 + Sbjct: 324 SGGDN 328 Score = 55.6 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 28/156 (17%), Positives = 57/156 (36%), Gaps = 13/156 (8%) Query: 187 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISID 246 G SK ++ + I ++ G RLA SD+TI+ +EI Sbjct: 42 GQSKVEINIVGSGGGSGGGSVTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEI-DG 100 Query: 247 DENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSG--TL 304 + VE + H + + ++ W F ++AS S ++ IW+ +G Sbjct: 101 ENQRLVETLIGH--EGPVWQVAWAHPKF-----GVILASC--SYDGKVLIWKEDNGVWNK 151 Query: 305 VRVLEGAEEELIDINWDFYS-MSIVSNGFESGNVYV 339 V + + ++W + ++ G + + Sbjct: 152 VAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISI 187 >3JRO-A nrPDB Length = 753 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 43/274 (15%), Positives = 96/274 (35%), Gaps = 25/274 (9%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS--PDGRLLLTSSRDW 94 G LA ++ + I++++ + + L H P+ + W+ G +L + S D Sbjct: 20 YGKRLATCSSDKTIKIFEVEGETHKLI--DTLTGHEGPVWRVDWAHPKFGTILASCSYDG 77 Query: 95 SIKLWDLSKP--SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 + +W S+ + + QW + + + V++F + S Sbjct: 78 KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 137 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVH-----TKHPNIIIVGTSKGWLDFYKFHSLYQTECI 207 + + TK + G + + +K++S QT + Sbjct: 138 PIIIDAHA-IGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 Query: 208 H-SLKITSSNIKHLIVSQNG---ERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 +L+ S ++ + S LA DRT + + L E K+ DV Sbjct: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 256 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 + + W+ + ++A + G +++ +W Sbjct: 257 LWRASWSL-------SGNVLALSGG--DNKVTLW 281 Score = 71.8 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 55/324 (16%), Positives = 111/324 (34%), Gaps = 38/324 (11%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPL--KEIRFDSPIWGCQWLDAKR 127 AH I G+ L T S D +IK++++ + L + P+W W K Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH--PNIII 185 +A+ + + S Q++ H + H +++ Sbjct: 67 GTILASCSYDGKVLIW----KEENGRWS-----QIAVHAVHSASVNSVQWAPHEYGPLLL 117 Query: 186 VGTSKGWLDFYKFHSLYQTECI----HSLKITSSNIKHLIVSQNG--------ERLAINC 233 V +S G + +F T I H++ + S++ + ++G + Sbjct: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 Query: 234 SDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHE 293 +D ++ ++ + D + +E TLE + D + + W+ + + YL + S Sbjct: 178 ADNLVKIWKYNSDAQTYVLESTLE-GHSDWVRDVAWSPTVLLRS---YLASV---SQDRT 230 Query: 294 LYIW--ETTSGTLVRVL---EGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKW 348 IW + G + L E + L +W + +G V +W + KW Sbjct: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG-GDNKVTLWKENLEGKW 289 Query: 349 SALAPDFEEVEENVDYLEKEDEFD 372 + + EFD Sbjct: 290 EPAGEVHQGGGGSGGGGATSKEFD 313 >5CXC-A nrPDB Length = 510 Score = 92.2 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 50/272 (18%), Positives = 91/272 (33%), Gaps = 28/272 (10%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIY---DMDTFRPICVPGNMLGAHVRPITSIAWS 81 + + +F D LA + + ++ + D F P L H + + Sbjct: 191 HTASIKAAKFL-TSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVD 249 Query: 82 PDGRLLLTSSRDWSIKLWDLSKPSKP------------LKEIRFDSPIWGCQWLDAKRRL 129 + +LT+S D +I W SK S P K + S + Q Sbjct: 250 GHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWS 309 Query: 130 C-----VATIFEESDAYVI-DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN- 182 A IF+ D V S D L + + +S+ +L + T+ Sbjct: 310 IHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTT 369 Query: 183 --IIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGER-LAINCSDRTIR 239 ++ GTS + + T + +L+ ++ + L S E L D T R Sbjct: 370 SPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCR 429 Query: 240 QYEISIDDENSAVELTLEHKYQD--VINKLQW 269 +++ + E +L + VI + W Sbjct: 430 VWDLRSVRPATKEEGSLGGVSEPVYVIERESW 461 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 50/340 (14%), Positives = 99/340 (29%), Gaps = 41/340 (12%) Query: 36 PCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWS 95 P + + +G L I++ P G H I + + R L ++ D + Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDR-LASAGMDRT 214 Query: 96 IKLWDLSK----PSKPLKEIRFDSPIWGCQWLD-AKRRLCVATIFEESDAYVIDFSNDPV 150 +++W ++ + + WLD + T + S Sbjct: 215 VRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKA-- 272 Query: 151 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL 210 S P+ L+ H S S Sbjct: 273 -------------SAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWS---------- 309 Query: 211 KITSSNIKHLIVSQNGERLA-INCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQW 269 I ++ I +A D T+R +++ S + LT L Sbjct: 310 -IHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLT--------HPLLSL 360 Query: 270 NCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVS 329 + + + T+ L A T + +++ T V L G +++ ++ + + Sbjct: 361 SALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLV 420 Query: 330 NGFESGNVYVWSVVIPPKWSALAPDFEEVEENVDYLEKED 369 +G G VW + + V E V +E+E Sbjct: 421 SGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERES 460 >3C9C-A nrPDB Length = 432 Score = 91.8 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 61/148 (41%), Gaps = 8/148 (5%) Query: 18 KLTHTIE-NPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 K +HT++ + CL F+P ++ LA G A+ + ++D+ R + + + +H I Sbjct: 270 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHSFESHKDEI 326 Query: 76 TSIAWSPDGRLL-LTSSRDWSIKLWDLSK-PSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + WSP + +S D + +WDLSK + E D P Sbjct: 327 FQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDF 386 Query: 134 IFEESDAY-VIDFSNDPVASLLSKSDEK 160 + ++ + + S D + + ++ Sbjct: 387 SWNPNEPWIICSVSEDNIMQVWQMAENV 414 Score = 90.3 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 45/253 (17%), Positives = 90/253 (35%), Gaps = 26/253 (10%) Query: 60 PICVPGNMLGAHVRPITSIAWSPD-GRLLLTSSRDWSIKLWDLSKPSKPLKEI------- 111 C P L H + ++W+P+ LL++S D +I LWD++ K + I Sbjct: 171 GECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFT 230 Query: 112 RFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYV 171 + + W L ++ ++ + D N+ + K + H Sbjct: 231 GHTAVVEDVAWHLLHESLF-GSVADDQKLMIWDTRNNNTS--------KPSHTVDAHTAE 281 Query: 172 LVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTEC-IHSLKITSSNIKHLIVSQ-NGERL 229 + C + I+ S L + +HS + I + S N L Sbjct: 282 VNCLSFNPYSEFILATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 339 Query: 230 AINCSDRTIRQYEISIDDENSAVELTLEHKYQD--VINKLQWNCILFSNNTAE-YLVAST 286 A + +DR + +++S E + E + + + FS N E +++ S Sbjct: 340 ASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSV 399 Query: 287 HGSSAHELYIWET 299 S + + +W+ Sbjct: 400 --SEDNIMQVWQM 410 Score = 78.4 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 31/246 (12%), Positives = 76/246 (30%), Gaps = 28/246 (11%) Query: 25 NPLRTECLQFSPCGD-YLALGCANGALVIYDMDTF---RPICVPGNMLGAHVRPITSIAW 80 + L ++P + YL + + ++D++ + N+ H + +AW Sbjct: 182 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 241 Query: 81 S-PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESD 139 L + + D + +WD + D+ L + S+ Sbjct: 242 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCL---------SFNPYSE 292 Query: 140 AYVIDFSNDPVASLLSKSDEK-QLSSTPDHGYVLVCTVHTKH-PNIIIVGTSKGWLDFYK 197 + S D +L + K +L S H + + H I+ + L + Sbjct: 293 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 352 Query: 198 FHSLYQT-----------ECIHSLKITSSNIKHLIVSQNGERLA-INCSDRTIRQYEISI 245 + + E + ++ I + N + D ++ ++++ Sbjct: 353 LSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 412 Query: 246 DDENSA 251 + N Sbjct: 413 NVYNDE 418 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 28/240 (11%), Positives = 87/240 (36%), Gaps = 19/240 (7%) Query: 110 EIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHG 169 +I + + +++ + +AT SD V D++ P + + + H Sbjct: 126 KINHEGEVNRARYMP-QNACVIATKTPSSDVLVFDYTKHP-SKPEPSGECQPDLRLRGHQ 183 Query: 170 YVLVCTVHTKHPN-IIIVGTSKGWLDFYKFHSLYQTECI----HSLKITSSNIKHLIVSQ 224 + N ++ + + + ++ + + + ++ ++ + Sbjct: 184 KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL 243 Query: 225 NGERLA-INCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLV 283 E L D+ + ++ ++ + H + NC+ F+ + L Sbjct: 244 LHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEV-------NCLSFNPYSEFILA 296 Query: 284 ASTHGSSAHELYIWETTSGTL-VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 GS+ + +W+ + L + E ++E+ + W ++ +I+++ ++VW + Sbjct: 297 T---GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDL 353 Score = 28.7 bits (62), Expect = 5.1, Method: Composition-based stats. Identities = 26/181 (14%), Positives = 60/181 (33%), Gaps = 41/181 (22%) Query: 250 SAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETT--------S 301 +E+ ++ ++ +N+ + A + T S ++ +++ T S Sbjct: 119 GKIEIEIKINHEGEVNR-----ARYMPQNACVIATKTPSS---DVLVFDYTKHPSKPEPS 170 Query: 302 GTLVR--VLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKW-------SALA 352 G L G ++E ++W+ + + + + +W + PK + Sbjct: 171 GECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFT 230 Query: 353 PDFEEVEENVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQYDVRGNNLLVERFT 412 VE+ +L E F V + ++ +D R NN T Sbjct: 231 GHTAVVEDVAWHLLHESLFGSVADDQKLM----------------IWDTRNNNTSKPSHT 274 Query: 413 I 413 + Sbjct: 275 V 275 >5K0Y-T nrPDB Length = 329 Score = 91.8 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 44/308 (14%), Positives = 100/308 (32%), Gaps = 12/308 (3%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 ++++ GD L + + ++ + H + + D + +LT S Sbjct: 16 IKYNREGDLLFTVAKDPIVNVWYSVNGERLG----TYMGHTGAVWCVDADWDTKHVLTGS 71 Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVA 151 D S +LWD K L ++ +S + C + + +T + + F + Sbjct: 72 ADNSCRLWDCET-GKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDP 130 Query: 152 SLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLK 211 S + + + P + + V II G G L+ Y S E + ++K Sbjct: 131 SQID--NNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQY---SAKSGEVLVNVK 185 Query: 212 ITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNC 271 S I + +S+ D T + ++ + + + + + Sbjct: 186 EHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAALSPNYEHVV 245 Query: 272 ILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNG 331 + A + ++ E + ++G + + + S+G Sbjct: 246 VG-GGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHP-DGKSYSSG 303 Query: 332 FESGNVYV 339 E G V + Sbjct: 304 GEDGYVRI 311 >4N14-A nrPDB Length = 314 Score = 91.5 bits (225), Expect = 7e-19, Method: Composition-based stats. Identities = 40/229 (17%), Positives = 86/229 (37%), Gaps = 23/229 (10%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 +L + + R L ++ L+ G +G + +D+ R L H + + Sbjct: 97 RLRNMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDV---RVAEHHVATLSGHSQEVCG 151 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPS---KPLKEI-RFDSPIWGCQWLDAKRRLCVAT 133 + W+PDGR L + D + +W + PL+ + + W + + Sbjct: 152 LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATG 211 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV-GTSKGW 192 ++D + + LS+ H V + +I G ++ Sbjct: 212 G----------GTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 261 Query: 193 LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 L +K+ ++ + + LK +S + L +S +G +A +D T+R + Sbjct: 262 LVIWKYPTMAK---VAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 38/332 (11%), Positives = 101/332 (30%), Gaps = 40/332 (12%) Query: 16 PEKLTHT--IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 73 P+++ I N + +S G+ LA+ + ++ ++ + + + Sbjct: 9 PDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPG--E 64 Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 I+S+AW +G L + ++LWD+ + + + + W Sbjct: 65 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW----------- 113 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEK-QLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGW 192 + + S + +++ H + + G + Sbjct: 114 ----NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 169 Query: 193 LDFYKFHSLYQT-ECIHSLKITSSNIKHLIVSQNGERLAI---NCSDRTIRQYEISIDDE 248 ++ + + + +K + + SDR IR + + Sbjct: 170 VNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS--- 226 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL 308 + + H + + S HG + ++L IW+ + V L Sbjct: 227 GACLSAVDAHS----------QVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAEL 276 Query: 309 EGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 +G ++ + + V++ + +W Sbjct: 277 KGHTSRVLSLTMSPDGAT-VASAAADETLRLW 307 Score = 79.5 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 27/184 (14%), Positives = 62/184 (33%), Gaps = 16/184 (8%) Query: 22 TIENPLRTEC-LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAW 80 T+ + C L+++P G +LA G + + ++ VP H + ++AW Sbjct: 141 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 200 Query: 81 SP-DGRLLLTSS--RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 P +L T D I++W++ + L + S + W + L F + Sbjct: 201 CPWQSNVLATGGGTSDRHIRIWNVCSGAC-LSAVDAHSQVCSILWSPHYKELISGHGFAQ 259 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 + + +++ H ++ + + + L ++ Sbjct: 260 NQLVI-----------WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 308 Query: 198 FHSL 201 L Sbjct: 309 CFEL 312 Score = 32.1 bits (71), Expect = 0.45, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 21/52 (40%), Gaps = 2/52 (3%) Query: 11 VLKEHPE--KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRP 60 V+ ++P K+ + R L SP G +A A+ L ++ P Sbjct: 263 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDP 314 >3CFV-B nrPDB Length = 414 Score = 91.1 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 30/142 (21%), Positives = 58/142 (40%), Gaps = 8/142 (5%) Query: 18 KLTHTIE-NPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 K +H ++ + CL F+P ++ LA G A+ + ++D+ R + + + +H I Sbjct: 266 KPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHTFESHKDEI 322 Query: 76 TSIAWSPDGRLL-LTSSRDWSIKLWDLSK-PSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + WSP + +S D + +WDLSK + E D P Sbjct: 323 FQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDF 382 Query: 134 IFEESDAYV-IDFSNDPVASLL 154 + ++ +V S D + + Sbjct: 383 SWNPNEPWVICSVSEDNIMQIW 404 Score = 84.5 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 44/343 (12%), Positives = 106/343 (30%), Gaps = 70/343 (20%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLA---LGCANGALVIYDMDTFRP----ICVPGNMLGA 70 + I + ++ P ++ ++ + Y +P C P L Sbjct: 118 ECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRG 177 Query: 71 HVRPITSIAWSPD-GRLLLTSSRDWSIKLWDLSKPSKPLKEI-------RFDSPIWGCQW 122 H + ++W+ + LL++S D ++ LWD++ K K + + + W Sbjct: 178 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 237 Query: 123 LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN 182 L ++ ++ + D ++ + K H + C + Sbjct: 238 HLLHESLF-GSVADDQKLMIWDTRSNTTS--------KPSHLVDAHTAEVNCLSFNPYSE 288 Query: 183 IIIVGTSKGWLDFYKFHSLYQTEC-IHSLKITSSNIKHLIVSQ-NGERLAINCSDRTIRQ 240 I+ S L + +H+ + I + S N LA + +DR + Sbjct: 289 FILATGS--ADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNV 346 Query: 241 YEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETT 300 +++S ++ E +D + Sbjct: 347 WDLS--------KIGEEQSAEDAEDGPP-------------------------------- 366 Query: 301 SGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 343 L+ + G ++ D +W+ ++ + E + +W + Sbjct: 367 --ELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 407 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 28/247 (11%), Positives = 75/247 (30%), Gaps = 30/247 (12%) Query: 25 NPLRTECLQFSPC-GDYLALGCANGALVIYDMDTF---RPICVPGNMLGAHVRPITSIAW 80 + L ++ +L + + ++D++ I + H + +AW Sbjct: 178 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 237 Query: 81 S-PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESD 139 L + + D + +WD ++ +DA F Sbjct: 238 HLLHESLFGSVADDQKLMIWDTRS----------NTTSKPSHLVDAHTAEVNCLSFNPYS 287 Query: 140 AYVI-DFSNDPVASLLSKSDEK-QLSSTPDHGYVLVCTVHTKH-PNIIIVGTSKGWLDFY 196 +++ S D +L + K +L + H + + H I+ + L+ + Sbjct: 288 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 347 Query: 197 KFHSLYQT-----------ECIHSLKITSSNIKHLIVSQNGERLA-INCSDRTIRQYEIS 244 + + E + ++ I + N + D ++ ++++ Sbjct: 348 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA 407 Query: 245 IDDENSA 251 + N Sbjct: 408 ENIYNDE 414 >4J0W-A nrPDB Length = 343 Score = 91.1 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 50/281 (17%), Positives = 95/281 (33%), Gaps = 36/281 (12%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + C+ S G YLA G + ++I++ + C H ++ +A+ Sbjct: 66 HSSHVLCMAISSDGKYLASGDRSKLILIWEAQS----CQHLYTFTGHRDAVSGLAFRRGT 121 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 L ++S D S+K+W++++ S + L R CV Sbjct: 122 HQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALS--RECCVTA----------- 168 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY---KFHSL 201 D + +E QL H + C H + ++ G G + + K L Sbjct: 169 GGRDGTVRVWKIPEESQL-VFYGHQGSIDCI-HLINEEHMVSGADDGSVALWGLSKKRPL 226 Query: 202 YQTECIHSLKITSSN-----IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTL 256 H L+ I + N + +A +R ++ + ++L Sbjct: 227 ALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCG--EGFRQLDLLC 284 Query: 257 EHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 + IN L+ FS ++ ++LVA G W Sbjct: 285 DIPLVGFINSLK-----FS-SSGDFLVAGV-GQEHRLGRWW 318 Score = 86.1 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 34/286 (11%), Positives = 86/286 (30%), Gaps = 28/286 (9%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA-------HVRPITS 77 + L CL +P + + +++ + +++ R + V H + Sbjct: 13 HQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLC 72 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 +A S DG+ L + R I +W+ + G F Sbjct: 73 MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGL-------------AFRR 119 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 + S+D + + ++ + + H + + G G + +K Sbjct: 120 GTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 179 Query: 198 FHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLE 257 E +I + + N E + D ++ + +S + Sbjct: 180 IPE----ESQLVFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHG 234 Query: 258 HKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGT 303 + + + + W + + + + +H S + +W+ G Sbjct: 235 LRGEPGLEQPFWISSVAALLNTDLVATGSHSSC---VRLWQCGEGF 277 Score = 81.1 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 43/292 (14%), Positives = 88/292 (30%), Gaps = 31/292 (10%) Query: 59 RPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIW 118 P +L H IT + +PD + ++++D SI W + K R Sbjct: 1 GPEAADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAE 60 Query: 119 GCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHT 178 G + LC+A + Y+ + + + L + H + Sbjct: 61 GKPPGHSSHVLCMAISSD--GKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR 118 Query: 179 KHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTI 238 + + + + + K ++ + + +L + L + D T+ Sbjct: 119 RGTHQLYSTSHDRSV---KVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTV 175 Query: 239 RQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 298 R ++I E S + D I+ + + G+ + +W Sbjct: 176 RVWKI---PEESQLVFYGHQGSIDCIHLINEEHM-------------VSGADDGSVALWG 219 Query: 299 TTSGT---LVRVLEGAEEEL-------IDINWDFYSMSIVSNGFESGNVYVW 340 + L R G E I + +V+ G S V +W Sbjct: 220 LSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW 271 >5Y1U-A nrPDB Length = 456 Score = 90.3 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 30/142 (21%), Positives = 59/142 (41%), Gaps = 8/142 (5%) Query: 18 KLTHTIE-NPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 K +H+++ + CL F+P ++ LA G A+ + ++D+ R + + + +H I Sbjct: 295 KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNLKLKLHSFESHKDEI 351 Query: 76 TSIAWSPDGRLL-LTSSRDWSIKLWDLSK-PSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + WSP + +S D + +WDLSK + E D P Sbjct: 352 FQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDF 411 Query: 134 IFEESDAYV-IDFSNDPVASLL 154 + ++ +V S D + + Sbjct: 412 SWNPNEPWVICSVSEDNIMQVW 433 Score = 88.8 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 46/252 (18%), Positives = 87/252 (34%), Gaps = 24/252 (9%) Query: 60 PICVPGNMLGAHVRPITSIAWSPD-GRLLLTSSRDWSIKLWDLSKPSKPLKEI------- 111 C P L H + ++W+P+ LL++S D +I LWD+S K K + Sbjct: 196 GECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT 255 Query: 112 RFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYV 171 + + W L ++ ++ + D ++ + K S H Sbjct: 256 GHTAVVEDVSWHLLHESLF-GSVADDQKLMIWDTRSNNTS--------KPSHSVDAHTAE 306 Query: 172 LVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTEC-IHSLKITSSNIKHLIVSQ-NGERL 229 + C + I+ S L + +HS + I + S N L Sbjct: 307 VNCLSFNPYSEFILATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 364 Query: 230 AINCSDRTIRQYEISIDDENSAVELTLEHKYQD--VINKLQWNCILFSNNTAEYLVASTH 287 A + +DR + +++S E + E + + + FS N E V Sbjct: 365 ASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI-CS 423 Query: 288 GSSAHELYIWET 299 S + + +W+ Sbjct: 424 VSEDNIMQVWQM 435 Score = 78.0 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 28/246 (11%), Positives = 74/246 (30%), Gaps = 28/246 (11%) Query: 25 NPLRTECLQFSPC-GDYLALGCANGALVIYDMDT---FRPICVPGNMLGAHVRPITSIAW 80 + L ++P +L + + ++D+ + + H + ++W Sbjct: 207 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 266 Query: 81 S-PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESD 139 L + + D + +WD + D+ L + S+ Sbjct: 267 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL---------SFNPYSE 317 Query: 140 AYVIDFSNDPVASLLSKSDEK-QLSSTPDHGYVLVCTVHTKH-PNIIIVGTSKGWLDFYK 197 + S D +L + K +L S H + + H I+ + L+ + Sbjct: 318 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 377 Query: 198 FHSLYQT-----------ECIHSLKITSSNIKHLIVSQNGERLA-INCSDRTIRQYEISI 245 + + E + ++ I + N + D ++ ++++ Sbjct: 378 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 437 Query: 246 DDENSA 251 + N Sbjct: 438 NIYNDE 443 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 44/301 (14%), Positives = 94/301 (31%), Gaps = 63/301 (20%) Query: 100 DLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS-----LL 154 D+++P K+ + G D + L +A++ +D D S+ Sbjct: 83 DVTRPEG--KDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFG 140 Query: 155 SKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHS------LYQTECI- 207 S S + ++ +H + + II + ++ EC Sbjct: 141 SVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNP 200 Query: 208 -HSLKITSSNIKHLIVSQNGE-RLAINCSDRTIRQYEISIDDENSAV--ELTLEHKYQDV 263 L+ L + N L D TI ++IS + V T+ + V Sbjct: 201 DLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAV 260 Query: 264 INKLQW-----------------------------------------NCILFSNNTAEYL 282 + + W NC+ F+ + L Sbjct: 261 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 320 Query: 283 VASTHGSSAHELYIWETTSGTL-VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 GS+ + +W+ + L + E ++E+ + W ++ +I+++ + VW Sbjct: 321 AT---GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 377 Query: 342 V 342 + Sbjct: 378 L 378 >3JRP-A nrPDB Length = 379 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 43/274 (15%), Positives = 96/274 (35%), Gaps = 25/274 (9%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS--PDGRLLLTSSRDW 94 G LA ++ + I++++ + + L H P+ + W+ G +L + S D Sbjct: 22 YGKRLATCSSDKTIKIFEVEGETHKLI--DTLTGHEGPVWRVDWAHPKFGTILASCSYDG 79 Query: 95 SIKLWDLSKP--SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 + +W S+ + + QW + + + V++F + S Sbjct: 80 KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 139 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVH-----TKHPNIIIVGTSKGWLDFYKFHSLYQTECI 207 + + TK + G + + +K++S QT + Sbjct: 140 PIIIDAHA-IGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 198 Query: 208 H-SLKITSSNIKHLIVSQNG---ERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 +L+ S ++ + S LA DRT + + L E K+ DV Sbjct: 199 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 258 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 + + W+ + ++A + G +++ +W Sbjct: 259 LWRASWSL-------SGNVLALSGG--DNKVTLW 283 Score = 68.3 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 52/300 (17%), Positives = 106/300 (35%), Gaps = 38/300 (12%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPL--KEIRFDSPIWGCQWLDAKR 127 AH I G+ L T S D +IK++++ + L + P+W W K Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH--PNIII 185 +A+ + + S Q++ H + H +++ Sbjct: 69 GTILASCSYDGKVLIW----KEENGRWS-----QIAVHAVHSASVNSVQWAPHEYGPLLL 119 Query: 186 VGTSKGWLDFYKFHSLYQTECI----HSLKITSSNIKHLIVSQNG--------ERLAINC 233 V +S G + +F T I H++ + S++ + ++G + Sbjct: 120 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 179 Query: 234 SDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHE 293 +D ++ ++ + D + +E TLE + D + + W+ + + YL + S Sbjct: 180 ADNLVKIWKYNSDAQTYVLESTLE-GHSDWVRDVAWSPTVLLRS---YLASV---SQDRT 232 Query: 294 LYIW--ETTSGTLVRVL---EGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKW 348 IW + G + L E + L +W + +G V +W + KW Sbjct: 233 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG-GDNKVTLWKENLEGKW 291 >5OQL-d nrPDB Length = 446 Score = 89.9 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 46/311 (14%), Positives = 95/311 (30%), Gaps = 36/311 (11%) Query: 41 LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 100 +A G +G + ++D+ T + AH + + ++ D + LL+ + D IKLWD Sbjct: 82 IASGSGDGVVKVWDLTTRDEETWR---VAAHNNIVKGLTFTND-KKLLSCATDG-IKLWD 136 Query: 101 ---LSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKS 157 + P+ + P + + A + + D + S Sbjct: 137 PYASPSNTTPIATWQEGGPYTSLSFH--RSANTFAASSGQGCIRIWDLEH---------S 185 Query: 158 DEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNI 217 Q P + + +I S L + + + Sbjct: 186 TAGQAIQWPSFVDTITDVCFNQVETSVI--GSVATDRSIILFDLRTNMPVIKTVLHFA-C 242 Query: 218 KHLIVSQ-NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN 276 ++ + LA+ D I ++ D+ A+ + H + + FS Sbjct: 243 NRIVFNPMEAMNLAVASEDHNIYIFDARNFDK--ALNIQKGHVAAVMD-------VEFSP 293 Query: 277 NTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGN 336 E + GS + +W +G V + + + G + GN Sbjct: 294 TGEELV----SGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGN 349 Query: 337 VYVWSVVIPPK 347 V +W + Sbjct: 350 VRLWRANASER 360 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 34/261 (13%), Positives = 89/261 (34%), Gaps = 21/261 (8%) Query: 3 ILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMD-TFRPI 61 I L DP+A T + L F + A G + I+D++ + Sbjct: 132 IKLWDPYASPSN--TTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQ 189 Query: 62 CVPGNMLGAHVRPITSIAWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGC 120 + V IT + ++ + ++ + + D SI L+DL +K + + Sbjct: 190 AIQWPSF---VDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFAC--NR 244 Query: 121 QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH 180 + + +A E+ + Y+ D N K L+ H ++ + Sbjct: 245 IVFNPMEAMNLAVASEDHNIYIFDARNFD----------KALNIQKGHVAAVMDVEFSPT 294 Query: 181 PNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQ 240 ++ G+ + ++ + + + H+ ++ + + + + + + D +R Sbjct: 295 GEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQR--VFRTMWTMDSKYILTGSDDGNVRL 352 Query: 241 YEISIDDENSAVELTLEHKYQ 261 + + + + + Sbjct: 353 WRANASERSGVKATRQRQALE 373 Score = 79.9 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 43/290 (14%), Positives = 103/290 (35%), Gaps = 32/290 (11%) Query: 55 MDTFRPICVPGNMLGAHVRPITSIAWSPDG-RLLLTSSRDWSIKLWDLSK-PSKPLKEIR 112 ++ G + HV+ + S+ + + + S D +K+WDL+ + + Sbjct: 49 LERMFAKPFLGQLGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAA 108 Query: 113 FDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVL 172 ++ + G + + K+ L AT + D S S+ +++ + G Sbjct: 109 HNNIVKGLTFTNDKKLLSCAT----DGIKLWD-------PYASPSNTTPIATWQEGG-PY 156 Query: 173 VCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ-NGERLAI 231 + N + +G + + + I I + +Q + Sbjct: 157 TSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQ-WPSFVDTITDVCFNQVETSVIGS 215 Query: 232 NCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSA 291 +DR+I +++ + ++ L N I+F+ A L + S Sbjct: 216 VATDRSIILFDLRTNMP--VIKTVLH---------FACNRIVFNPMEAMNLAVA---SED 261 Query: 292 HELYIWETTS-GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 H +YI++ + + + +G ++D+ + +VS G + +W Sbjct: 262 HNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVS-GSYDRTIRLW 310 >3JAP-g nrPDB Length = 326 Score = 89.9 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 42/322 (13%), Positives = 100/322 (31%), Gaps = 49/322 (15%) Query: 39 DYLALGCANGALVIYDM-DTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK 97 + L G + L+ + + + + VP H + + S DG +++S D +++ Sbjct: 32 NLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASWDKTLR 91 Query: 98 LWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKS 157 LW+L+ + + + + + + + +I S D + + Sbjct: 92 LWNLATGNSEARFVGHTGDVLSVAI-------------DANSSKIISASRDKTIRVWNT- 137 Query: 158 DEKQLSSTPDHGYVLVCTVHTKH-------PNIIIVGTSKGWLDFYKFHSLYQT--ECIH 208 H + + I S G + SL + Sbjct: 138 VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEA 197 Query: 209 SLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQ 268 ++ I + S +G A D I + + + + + K + Sbjct: 198 DFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKH-----------KSAFMNFDAKDE 246 Query: 269 WNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL--------EGAEEELIDINW 320 + FS + A+ G + I++ + L+ L + + + + W Sbjct: 247 VFALAFSPSRFWLTAATASG-----IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAW 301 Query: 321 DFYSMSIVSNGFESGNVYVWSV 342 ++ + G+ + VW V Sbjct: 302 SADGQTLFA-GYTDNVIRVWQV 322 Score = 89.1 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 31/284 (10%), Positives = 83/284 (29%), Gaps = 27/284 (9%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + + + S G+Y + L ++++ T H + S+A + Sbjct: 65 HSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEA----RFVGHTGDVLSVAIDANS 120 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 ++++SRD +I++W+ + + + ++ + Sbjct: 121 SKIISASRDKTIRVWNTV-GDCAYVLLGHTDWVTKVRVAPKNLED---GEVDDGRITFVS 176 Query: 145 FSNDPVASLLSK--SDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLY 202 D + S + + H + + ++ G + + Sbjct: 177 AGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNL---- 232 Query: 203 QTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI--SIDDENSAVELTLEHKY 260 + + + L S + L + I+ Y++ + + E K Sbjct: 233 KHKSAFMNFDAKDEVFALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKPEFAGYTKA 291 Query: 261 QDVIN-KLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGT 303 QD L W S + G + + + +W+ + Sbjct: 292 QDPHAVSLAW-----SADGQTLFA----GYTDNVIRVWQVMTAN 326 Score = 84.9 bits (208), Expect = 6e-17, Method: Composition-based stats. Identities = 44/312 (14%), Positives = 105/312 (33%), Gaps = 38/312 (12%) Query: 55 MDTFRPICVPGNMLGAHVRPITSIAWSPDG-RLLLTSSRDWSIKLWDLSKPSKPLKEIRF 113 M + + V L H +TS++ S LL++ SRD ++ W L++ + +F Sbjct: 1 MSSSNIMLVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQ-----QF 55 Query: 114 DSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV 173 P+ + + Y + S D L + + + H ++ Sbjct: 56 GVPVRS---YKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVL 112 Query: 174 CTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ--------- 224 + + II + + + +C + L + + + V+ Sbjct: 113 SVAIDANSSKIISASRDKTIRVWNT----VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVD 168 Query: 225 NGE-RLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLV 283 +G D+ +R + ++ D + + Y +V+ + L Sbjct: 169 DGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQ----------PSPDGSLA 218 Query: 284 ASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 343 AS ++Y+W + + A++E+ + + ++ SG + ++ + Sbjct: 219 ASA--GKDGQIYVWNLKHKSAFMNFD-AKDEVFALAFSPSRF-WLTAATASG-IKIYDLE 273 Query: 344 IPPKWSALAPDF 355 L P+F Sbjct: 274 NEVLIDELKPEF 285 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 31/244 (12%), Positives = 73/244 (29%), Gaps = 43/244 (17%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 + + + + + + +++ + +L H +T + +P Sbjct: 105 VGHTGDVLSVAIDANSSKIISASRDKTIRVWN-----TVGDCAYVLLGHTDWVTKVRVAP 159 Query: 83 ---------DGR-LLLTSSRDWSIKLWDLSKPSKPLKE--IRFDSPIWGCQWLDAKRRLC 130 DGR +++ D ++ W L++ S ++ I ++ I Q Sbjct: 160 KNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGS--L 217 Query: 131 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSK 190 A+ ++ YV + + + + + T+ Sbjct: 218 AASAGKDGQIYVWNLKHKSAFMNFDAK------------DEVFALAFSPSRFWLTAATAS 265 Query: 191 GWLDFYKFHSLYQTECIHSL--------KITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 G K + L I L K + L S +G+ L +D IR ++ Sbjct: 266 G----IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQ 321 Query: 243 ISID 246 + Sbjct: 322 VMTA 325 Score = 31.7 bits (70), Expect = 0.67, Method: Composition-based stats. Identities = 10/55 (18%), Positives = 21/55 (38%) Query: 5 LQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFR 59 L++ + + PE +T L +S G L G + + ++ + T Sbjct: 272 LENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 326 >4A11-B nrPDB Length = 408 Score = 89.5 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 54/358 (15%), Positives = 115/358 (32%), Gaps = 50/358 (13%) Query: 25 NPLRTECLQFSP-CGDYLALGCANGALVIYDMD--------TFRPICVPGNML-GAHVRP 74 + L P G Y+ G ++G +V+YD++ T + +C G H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 75 ITSIAWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + ++ W P D + +SS D ++K+WD + F+ ++ + C Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTA-DVFNFEETVYSHHMSPVSTKHC--- 157 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH-PNIIIVGTSKGW 192 V + P L H ++ + I+ ++ Sbjct: 158 -------LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSR 210 Query: 193 LDFYKFH---------SLYQTECIHSL----KITSSNIKHLIVSQNGERLAINCSDRTIR 239 + + + + ++ + + L + +G L +D +R Sbjct: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 Query: 240 QYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 299 + S + TL + + N + S + V +GS + ++ Sbjct: 271 LWNSSNGEN------TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS---TIAVYTV 321 Query: 300 TSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEE 357 SG + +L+G + + + + S G N+ W P PD +E Sbjct: 322 YSGEQITMLKGHYKTVDCCVFQSNFQELYS-GSRDCNILAW----VPSLYEPVPDDDE 374 Score = 68.0 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 26/192 (13%), Positives = 65/192 (33%), Gaps = 22/192 (11%) Query: 19 LTHTIENP-LRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGA------ 70 +H ++ + +SP DY LA A+ + ++D+ + + Sbjct: 178 CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAV 237 Query: 71 ------HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLD 124 H + + ++ DG LLT D ++LW+ S L + + + Sbjct: 238 ESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTL--------VNYGKVCN 289 Query: 125 AKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNII 184 ++ T+ + + ++ + +Q++ H + C V + + Sbjct: 290 NSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQEL 349 Query: 185 IVGTSKGWLDFY 196 G+ + + Sbjct: 350 YSGSRDCNILAW 361 Score = 55.2 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 25/208 (12%), Positives = 72/208 (34%), Gaps = 26/208 (12%) Query: 148 DPVASLLSKSDEKQLSSTPDHGYVLVCTVHTK-HPNIIIVGTSKGWLDFYKFHSLYQTEC 206 + +L K HG + ++ G S G + Y + + Sbjct: 22 ESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLEN-SSRQS 80 Query: 207 IHSLK-----------ITSSNIKHLIVSQNGERLAINCS-DRTIRQYEISIDDENSAVEL 254 ++ K + +++ + + + + S D+T++ ++ + ++ Sbjct: 81 YYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT------NTLQT 134 Query: 255 TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEE 314 +++ + + S V G+ ++ + + SG+ +L+G +E Sbjct: 135 ADVFNFEETV--YSHHMSPVSTKHCLVAV----GTRGPKVQLCDLKSGSCSHILQGHRQE 188 Query: 315 LIDINWDFYSMSIVSNGFESGNVYVWSV 342 ++ ++W I++ V +W V Sbjct: 189 ILAVSWSPRYDYILATASADSRVKLWDV 216 Score = 28.3 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 11/68 (16%), Positives = 23/68 (33%), Gaps = 1/68 (1%) Query: 17 EKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPG-NMLGAHVRPI 75 E++T + +C F L G + ++ + + P+ + + P Sbjct: 325 EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPA 384 Query: 76 TSIAWSPD 83 AWS Sbjct: 385 FEDAWSSS 392 >4BZK-B nrPDB Length = 297 Score = 88.8 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 43/274 (15%), Positives = 96/274 (35%), Gaps = 25/274 (9%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS--PDGRLLLTSSRDW 94 G LA ++ + I++++ + + L H P+ + W+ G +L + S D Sbjct: 20 YGKRLATCSSDKTIKIFEVEGETHKLI--DTLTGHEGPVWRVDWAHPKFGTILASCSYDG 77 Query: 95 SIKLWDLSKP--SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 + +W S+ + + QW + + + V++F + S Sbjct: 78 KVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS 137 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTVH-----TKHPNIIIVGTSKGWLDFYKFHSLYQTECI 207 + + TK + G + + +K++S QT + Sbjct: 138 PIIIDAHA-IGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVL 196 Query: 208 H-SLKITSSNIKHLIVSQNG---ERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 +L+ S ++ + S LA DRT + + L E K+ DV Sbjct: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 256 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 + + W+ + ++A + G +++ +W Sbjct: 257 LWRASWSL-------SGNVLALSGG--DNKVTLW 281 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 50/300 (16%), Positives = 104/300 (34%), Gaps = 38/300 (12%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPL--KEIRFDSPIWGCQWLDAKR 127 AH I G+ L T S D +IK++++ + L + P+W W K Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH--PNIII 185 +A+ + + S Q++ H + H +++ Sbjct: 67 GTILASCSYDGKVLIW----KEENGRWS-----QIAVHAVHSASVNSVQWAPHEYGPLLL 117 Query: 186 VGTSKGWLDFYKFHSLYQTECI----HSLKITSSNIKHLIVSQNG--------ERLAINC 233 V +S G + +F T I H++ + S++ + ++G + Sbjct: 118 VASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 177 Query: 234 SDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHE 293 +D ++ ++ + D + +E TLE + D + + W+ + + YL + S Sbjct: 178 ADNLVKIWKYNSDAQTYVLESTLE-GHSDWVRDVAWSPTVLLRS---YLASV---SQDRT 230 Query: 294 LYIWETTS-----GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKW 348 IW + + E + L +W + +G V +W + KW Sbjct: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG-GDNKVTLWKENLEGKW 289 >5WJC-A nrPDB Length = 430 Score = 88.4 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 51/304 (16%), Positives = 103/304 (33%), Gaps = 28/304 (9%) Query: 15 HPEKLTHTIENPLRTECLQFSPCG-DYLALGCANGALVIYDM----DTFRPICVPGNMLG 69 + +++ I + ++ P + +A G I+D +P +L Sbjct: 120 YTIEISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLK 179 Query: 70 AHVRPITSIAWSPD--GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKR 127 H + W+P+ G L T + D I LWD+ S E + SPI Sbjct: 180 GHTAEGFGLCWNPNLPGN-LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIV 238 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKS---DEKQLSSTPDHGYVLVCTVHTK-HPNI 183 + +A + S+D + +E+ H + + + Sbjct: 239 NDV--QFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYL 296 Query: 184 IIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGE-RLAINCSDRTIRQYE 242 + ++ + + + YQ +H+L+ + L S + E LA + +DR + ++ Sbjct: 297 LATASADKTVALWDLRNPYQR--LHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWD 354 Query: 243 ISIDDENSAVE------LTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYI 296 + E E L + N++ FS E V + + + L I Sbjct: 355 LEKIGEEQTPEDAEDGSPELLFMHGGHTNRIS----EFSWCPNERWVVGSL-ADDNILQI 409 Query: 297 WETT 300 W + Sbjct: 410 WSPS 413 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 37/247 (14%), Positives = 91/247 (36%), Gaps = 24/247 (9%) Query: 106 KPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSST 165 + ++I D + +++ ++ +AT+ E +AY+ D + L+ + + Sbjct: 123 EISQKIPHDGDVNRARYMP-QKPEIIATMGEGGNAYIFDTT---CHDALTTGEALPQAVL 178 Query: 166 PDHGYV-LVCTVHTKHPNIIIVGTSKGWLDFYKFHS-------LYQTECIHSLKITSSNI 217 H + P + G + + + I + + Sbjct: 179 KGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIV 238 Query: 218 KHLIVSQNGERLAINCSDR-TIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN 276 + E L + SD T++ ++ ++ E A ++ + IN + N Sbjct: 239 NDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVI--QAHSKAINAVAINPF---- 292 Query: 277 NTAEYLVASTHGSSAHELYIWETTSG-TLVRVLEGAEEELIDINWDFYSMSIVSNGFESG 335 +YL+A+ S+ + +W+ + + LEG E+E+ + W + I+++ Sbjct: 293 --NDYLLATA--SADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDR 348 Query: 336 NVYVWSV 342 V +W + Sbjct: 349 RVCIWDL 355 >4YCZ-A nrPDB Length = 876 Score = 88.4 bits (217), Expect = 6e-18, Method: Composition-based stats. Identities = 45/345 (13%), Positives = 102/345 (29%), Gaps = 63/345 (18%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS--PDGRLLLTSSRDW 94 G LA ++ + I++++ L H + ++W+ G +L ++ D Sbjct: 29 YGRRLATCSSDRTIKIFEIEGETQRLT--ETLKGHDGAVWCVSWAHPKYGNILASAGYDG 86 Query: 95 SIKLWDLSKP--SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDP--- 149 + +W + + + W + +A + + V++F ++ Sbjct: 87 KVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEH 146 Query: 150 ----------VASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFH 199 + + + ++P + + G S L + + Sbjct: 147 SIFHAHGLGVNSVSWAPA------TSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYD 200 Query: 200 SLYQTECIHS--LKITSSNIKHLIVSQNG---ERLAINCSDRTIRQYEISIDDENSAVEL 254 T + L + ++ + S +A DRT+R + Sbjct: 201 PATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWT------------ 248 Query: 255 TLEHKYQDVINKLQWNCI---------LFSNNTAEYLVASTHGSSAHELYIWETTSG--- 302 D N LQWNC S + + ++A++ G +++ +W+ Sbjct: 249 ------SDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGG--DNKVTLWKENLKGEW 300 Query: 303 TLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPK 347 V+ +E G V W PK Sbjct: 301 ECVKTIEEGGGGSGGGGQAKGPTQPEQASPAKGFVK-WPYQQRPK 344 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 39/301 (12%), Positives = 90/301 (29%), Gaps = 38/301 (12%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKE--IRFDSPIWGCQWLDAKR 127 H I GR L T S D +IK++++ ++ L E D +W W K Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKY 75 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVG 187 +A+ + + N + + K +V + ++ Sbjct: 76 GNILASAGYDGKVLIWRELNGAWQRIFDFALHKA-------SVNVVSWSPHEAGCLLACA 128 Query: 188 TSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQN-----------------GERLA 230 +S G + +F I + + + R Sbjct: 129 SSDGNVSVLEFRDNSWEHSI--FHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFV 186 Query: 231 INCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSS 290 SD ++ + +E + D + + W+ + Y+ ++ S Sbjct: 187 TGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVL---QKSYIASA---SE 240 Query: 291 AHELYIWETTSGTLVR---VLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPK 347 + IW + ++ + + + ++W + ++G V +W + + Sbjct: 241 DRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASG-GDNKVTLWKENLKGE 299 Query: 348 W 348 W Sbjct: 300 W 300 Score = 58.7 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 51/143 (35%), Gaps = 13/143 (9%) Query: 200 SLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHK 259 S+ + + I ++ G RLA SDRTI+ +EI + E H Sbjct: 4 SMAAGTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIE-GETQRLTETLKGH- 61 Query: 260 YQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEG--AEEELID 317 + W S +Y ++ IW +G R+ + + + Sbjct: 62 -----DGAVW---CVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNV 113 Query: 318 INWDFY-SMSIVSNGFESGNVYV 339 ++W + + +++ GNV V Sbjct: 114 VSWSPHEAGCLLACASSDGNVSV 136 >4AEZ-A nrPDB Length = 401 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 78/232 (33%), Gaps = 17/232 (7%) Query: 17 EKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 KL + R CL ++ L+ G +GA+ +D+ R L H + Sbjct: 167 TKLRTMAGHQARVGCLSWNR--HVLSSGSRSGAIHHHDV---RIANHQIGTLQGHSSEVC 221 Query: 77 SIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 +AW DG L + D +++WD + ++ + W + L Sbjct: 222 GLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGG-- 279 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV-GTSKGWLDF 195 + D + + ++++ V I+ G L Sbjct: 280 --------GTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSI 331 Query: 196 YKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDD 247 + + S T+ + + + + + +S +G L+ SD ++ + + D Sbjct: 332 WSYSSSGLTKQV-DIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGD 382 Score = 74.9 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 39/301 (12%), Positives = 87/301 (28%), Gaps = 41/301 (13%) Query: 48 GALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKP 107 + +++ D+ + + S+ WS DG L + + ++D+ +K Sbjct: 113 RNVYVWNADSGSVSALAETD---ESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKL 169 Query: 108 LKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKS-DEKQLSSTP 166 + + W R + S Q+ + Sbjct: 170 RTMAGHQARVGCLSW---NRHVLS------------SGSRSGAIHHHDVRIANHQIGTLQ 214 Query: 167 DHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNG 226 H + + G G + + + + ++ +K + Sbjct: 215 GHSSEVCGLAWRSDGLQLASG---GNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQ 271 Query: 227 ERLAI---NCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLV 283 L D+ I + + + V+ + + L W S ++ E + Sbjct: 272 SNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ------VTSLIW-----SPHSKE--I 318 Query: 284 ASTHGSSAHELYIWETTSGTLVRV--LEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 STHG + L IW +S L + + + ++ I+S N+ W Sbjct: 319 MSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSP-DGRILSTAASDENLKFWR 377 Query: 342 V 342 V Sbjct: 378 V 378 Score = 73.0 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 51/309 (16%), Positives = 111/309 (35%), Gaps = 54/309 (17%) Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPS-KPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 + WS ++ + + ++ +W+ S L E + + +W L V Sbjct: 99 LDWSNLN--VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSV----- 151 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY 196 + + + + +L + H + C + +++ G+ G + Sbjct: 152 --------GLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNR--HVLSSGSRSGAIH-- 199 Query: 197 KFHSLYQ-TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELT 255 H + I +L+ SS + L +G +LA +D ++ ++ Sbjct: 200 -HHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFT---- 254 Query: 256 LEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEEL 315 + N + L+A+ G+ +++ W +G V ++ A ++ Sbjct: 255 -----KTNHNAAVKAVAWCPWQSN--LLATGGGTMDKQIHFWNAATGARVNTVD-AGSQV 306 Query: 316 IDINWDFYSMSIVSN-GFESGNVYVWS---------VVIPPK-----WSALAPDFEEV-- 358 + W +S I+S GF N+ +WS V IP +SAL+PD + Sbjct: 307 TSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILST 366 Query: 359 ---EENVDY 364 +EN+ + Sbjct: 367 AASDENLKF 375 Score = 28.3 bits (61), Expect = 7.1, Method: Composition-based stats. Identities = 8/44 (18%), Positives = 15/44 (34%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 SP G L+ ++ L + + + P + IT Sbjct: 356 ALSPDGRILSTAASDENLKFWRVYDGDHVKRPIPITKTPSSSIT 399 >3BG0-A nrPDB Length = 316 Score = 84.5 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 43/283 (15%), Positives = 97/283 (34%), Gaps = 33/283 (11%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS-PD-GRLLLTSSRDW 94 G LA ++ ++ I+D+ I + L H P+ +AW+ P G +L + S D Sbjct: 24 YGTRLATCSSDRSVKIFDVRNGGQILIAD--LRGHEGPVWQVAWAHPMYGNILASCSYDR 81 Query: 95 SIKLWDLSKP--SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 + +W K + DS + W L +A + ++ ++ + Sbjct: 82 KVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE 141 Query: 153 LLSKSDEKQLSSTPDHGYVLVCTV---HTKHPNI------IIVGTSKGWLDFYKFHSLYQ 203 + ++ + V G + +K Q Sbjct: 142 VKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQ 201 Query: 204 TECIHSLKITSSNIKHLIVSQN----GERLAINCSDRTIRQYEISIDDENSAV--ELTLE 257 + L+ S ++ + + + +A D + + D+ S+ L Sbjct: 202 WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW---TCDDASSNTWSPKLL 258 Query: 258 HKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETT 300 HK+ DV+ W+ S + ++A + G +++ +W+ + Sbjct: 259 HKFNDVV----WH---VSWSITANILAVSGG--DNKVTLWKES 292 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 46/311 (14%), Positives = 96/311 (30%), Gaps = 38/311 (12%) Query: 61 ICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPL--KEIRFDSPIW 118 + V + +H I G L T S D S+K++D+ + L + P+W Sbjct: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 Query: 119 GCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHT 178 W +A+ + + KS E + D VC Sbjct: 62 QVAWAHPMYGNILASCSYDRKVIIW----REENGTWEKSHE---HAGHDSSVNSVCWAPH 114 Query: 179 KHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNG------------ 226 + I+ G+S G + + Q E + + + Sbjct: 115 DYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQ 174 Query: 227 -----ERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEY 281 +R A D I+ + +++ E + D + + W + + Sbjct: 175 KPNYIKRFASGGCDNLIKLW--KEEEDGQWKEEQKLEAHSDWVRDVAW-----APSIGLP 227 Query: 282 LVASTHGSSAHELYIW---ETTSGTLV-RVLEGAEEELIDINWDFYSMSIVSNGFESGNV 337 S ++IW + +S T ++L + + ++W + + +G V Sbjct: 228 TSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSG-GDNKV 286 Query: 338 YVWSVVIPPKW 348 +W + +W Sbjct: 287 TLWKESVDGQW 297 Score = 34.1 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 26/72 (36%), Gaps = 4/72 (5%) Query: 32 LQFSPC----GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 87 + ++P +A +G + I+ D +L + ++WS +L Sbjct: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANIL 277 Query: 88 LTSSRDWSIKLW 99 S D + LW Sbjct: 278 AVSGGDNKVTLW 289 >5WLC-LU nrPDB Length = 489 Score = 83.8 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 51/349 (14%), Positives = 109/349 (31%), Gaps = 44/349 (12%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-----------DGRLL 87 + LA G A+G + ++M T AH +T + + + Sbjct: 81 NKLATGSADGVIKYWNMSTREEFV----SFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFM 136 Query: 88 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDF-S 146 L+ S D ++KLW ++ K + + + L A +S F + Sbjct: 137 LSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFAT 196 Query: 147 NDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN-IIIVGTSKGWLDFYKFHS-LYQT 204 L + K +S + ++ I+ S + Y + Sbjct: 197 GGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQ 256 Query: 205 ECIHSLKITSSNIKHLIVSQ-NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 + + +++ + + D Y++ + ++ + +H + Sbjct: 257 KIVQTMRT-----NAICWNPMEAFNFVTANEDHNAYYYDMRNL--SRSLNVFKDHVSAVM 309 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFY 323 + FS E + GS + I++T G + + + + Y Sbjct: 310 D-------VDFSPTGDEIVT----GSYDKSIRIYKTNHGHSREIY--HTKRMQHVFQVKY 356 Query: 324 SM--SIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEENVDYLEKEDE 370 SM + +G + GNV +W W + ++Y EK E Sbjct: 357 SMDSKYIISGSDDGNVRLW---RSKAWERSNVKTTREKNKLEYDEKLKE 402 Score = 81.1 bits (198), Expect = 9e-16, Method: Composition-based stats. Identities = 45/306 (14%), Positives = 104/306 (33%), Gaps = 37/306 (12%) Query: 55 MDTFRPICVPGNMLGAHVRPITSIAWSPDG-RLLLTSSRDWSIKLWDLSKPSKPLKEIRF 113 ++ G + H + +IA + L T S D IK W++S + + Sbjct: 50 LERMFAKPFVGQLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAH 109 Query: 114 DSPIWGCQWLDAK---------RRLCVATIFEESDAYVI-----DFSNDPVASLLSKSDE 159 + G + + + + ++ + D+SN + S ++E Sbjct: 110 YGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNE 169 Query: 160 KQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKH 219 + L T D + + G +K + + + + L + NI Sbjct: 170 EGLIRTFDGESAFQGIDSHRENSTFATGGAK-----IHLWDVNRLKPVSDLSWGADNITS 224 Query: 220 LIVSQNGER-LAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNT 278 L +QN LA SD +I Y++ + Q ++ ++ N I ++ Sbjct: 225 LKFNQNETDILASTGSDNSIVLYDLRTNSP-----------TQKIVQTMRTNAICWNPME 273 Query: 279 AEYLVASTHGSSAHELYIWETTS-GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNV 337 A V + + H Y ++ + + V + ++D+++ + G ++ Sbjct: 274 AFNFVTA---NEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDE-IVTGSYDKSI 329 Query: 338 YVWSVV 343 ++ Sbjct: 330 RIYKTN 335 Score = 52.6 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 52/127 (40%), Gaps = 7/127 (5%) Query: 19 LTHTIENPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 T I +RT + ++P + + YDM R + N+ HV + Sbjct: 254 PTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDM---RNLSRSLNVFKDHVSAVMD 310 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKP-SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 + +SP G ++T S D SI+++ + S+ + + ++ ++ + + + + Sbjct: 311 VDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGS--D 368 Query: 137 ESDAYVI 143 + + + Sbjct: 369 DGNVRLW 375 Score = 29.1 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 7/41 (17%), Positives = 18/41 (43%), Gaps = 1/41 (2%) Query: 14 EHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYD 54 H ++ HT + +++S Y+ G +G + ++ Sbjct: 337 GHSREIYHT-KRMQHVFQVKYSMDSKYIISGSDDGNVRLWR 376 Score = 28.7 bits (62), Expect = 5.6, Method: Composition-based stats. Identities = 6/46 (13%), Positives = 21/46 (45%) Query: 310 GAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDF 355 G + + I ++ S++ ++ G G + W++ ++ + + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHY 110 >5MWJ-A nrPDB Length = 337 Score = 81.4 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 36/272 (13%), Positives = 85/272 (31%), Gaps = 31/272 (11%) Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLC 130 H + ++ S R + T + +K+WD+S P SP+ L+ + Sbjct: 50 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNK-------SPVSQLDCLNRDNYIR 101 Query: 131 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVC--TVHTKHPNIIIVGT 188 + + ++ S+ + C + + Sbjct: 102 SCKLLPDGCTLIV-GGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCC 160 Query: 189 SKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDE 248 S G + L+ + + + + +S +G +L D T+R +++ E Sbjct: 161 SDGNI---AVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLR---E 214 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL 308 ++ +H + I L + T E+L S+ L++ + L Sbjct: 215 GRQLQ---QHDFTSQIFSLGY------CPTGEWLAVGMESSNVEVLHV----NKPDKYQL 261 Query: 309 EGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 E ++ + + Y + + + W Sbjct: 262 HLHESCVLSLKFA-YCGKWFVSTGKDNLLNAW 292 Score = 78.7 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 30/226 (13%), Positives = 60/226 (26%), Gaps = 20/226 (8%) Query: 16 PEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 P + + P G L +G L I+D+ P L + Sbjct: 87 PVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAE--LTSSAPAC 144 Query: 76 TSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIF 135 ++A SPD ++ + D +I +WDL + + Sbjct: 145 YALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS------------ 192 Query: 136 EESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDF 195 + D + +QL D + + + VG ++ Sbjct: 193 -NDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEV 250 Query: 196 YKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 + L + S + L + G+ D + + Sbjct: 251 LHV----NKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAW 292 Score = 75.3 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 39/229 (17%), Positives = 72/229 (31%), Gaps = 23/229 (10%) Query: 16 PEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 P + L SP C++G + ++D+ + H Sbjct: 131 PRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLV----RQFQGHTDGA 186 Query: 76 TSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIF 135 + I S DG L T D +++ WDL + + L++ F S I+ + L V Sbjct: 187 SCIDISNDGTKLWTGGLDNTVRSWDLRE-GRQLQQHDFTSQIFSLGYCPTGEWLAVGMES 245 Query: 136 EESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDF 195 ++K D+ QL H ++ + S G + Sbjct: 246 SN-----------VEVLHVNKPDKYQLHL---HESCVLSLKFAYCGKWFV---STGKDNL 288 Query: 196 YKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 244 I K SS++ +S + + + D+ YE+ Sbjct: 289 LNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEVI 336 >5A31-R nrPDB Length = 386 Score = 81.4 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 36/227 (15%), Positives = 80/227 (35%), Gaps = 18/227 (7%) Query: 18 KLTHTIENPL-RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 K T+ + R CL ++ L G + ++ D+ P + +H + + Sbjct: 164 KCIRTLSGHIDRVACLSWN--NHVLTSGSRDHRILHRDVRMPDPFF---ETIESHTQEVC 218 Query: 77 SIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 + W+ L + D + +++ + S L + + W KR + Sbjct: 219 GLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGG-- 276 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY 196 + D + + + ++S D G + V +K+ N ++ + Sbjct: 277 --------GTADRRLKIWNVNTSIKMSDI-DSGSQICNMVWSKNTNELVTSHGYSKYNL- 326 Query: 197 KFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 + I LK S + HL +S +G + D T+R +++ Sbjct: 327 TLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 Score = 68.3 bits (165), Expect = 6e-12, Method: Composition-based stats. Identities = 36/274 (13%), Positives = 85/274 (31%), Gaps = 36/274 (13%) Query: 73 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVA 132 TS++W G L + ++++D+ K + W Sbjct: 132 NEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW---------- 181 Query: 133 TIFEESDAYVIDFSNDPVASLLSKSDEKQLS-STPDHGYVLVCTVHTKHPNIIIVGTSKG 191 ++ + S D + H + N + G G Sbjct: 182 -----NNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASG---G 233 Query: 192 WLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAI---NCSDRTIRQYEISIDDE 248 + + I + + +K + S + + +DR ++ + ++ + Sbjct: 234 NDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIK 293 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL 308 S ++ + + W S NT E + + HG S + L +W+ S + +L Sbjct: 294 MSDIDSGSQIC------NMVW-----SKNTNELVTS--HGYSKYNLTLWDCNSMDPIAIL 340 Query: 309 EGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 +G ++ + + V +G + W + Sbjct: 341 KGHSFRVLHLTLS-NDGTTVVSGAGDETLRYWKL 373 Score = 68.3 bits (165), Expect = 7e-12, Method: Composition-based stats. Identities = 34/200 (17%), Positives = 76/200 (38%), Gaps = 20/200 (10%) Query: 16 PEKLTHTIENPLRTEC-LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRP 74 P+ TIE+ + C L+++ + LA G + + +Y+ + PI H Sbjct: 203 PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPIL----TFDEHKAA 258 Query: 75 ITSIAWSPDGR-LLLTSS--RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCV 131 + ++AWSP R +L T D +K+W+++ K + +I S I W L Sbjct: 259 VKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIK-MSDIDSGSQICNMVWSKNTNELVT 317 Query: 132 ATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKG 191 + + + + +L + ++ H + ++ + ++ G Sbjct: 318 SHGYSKYNL-----------TLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDE 366 Query: 192 WLDFYKFHSLYQTECIHSLK 211 L ++K + ++ Sbjct: 367 TLRYWKLFDVSVLNLFTRIR 386 >3F3P-A nrPDB Length = 351 Score = 81.1 bits (198), Expect = 9e-16, Method: Composition-based stats. Identities = 52/331 (15%), Positives = 117/331 (35%), Gaps = 32/331 (9%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAW-SPD-GRLLLT 89 + + G ++A ++ + ++ +D + AH I +I W SP+ GR++ + Sbjct: 17 VVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIAS 76 Query: 90 SSRDWSIKLWDLSKPSKPLKEIRFD---------SPIWGCQWLDAKRRLCVATIFEESDA 140 +S D ++KLW+ + R++ ++ ++ A L +A + + Sbjct: 77 ASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGIL 136 Query: 141 YVIDFSNDPVASLLSKSDEKQLSSTP--DHGYVLVCTVHTK---HPNIIIVGTSKGWLDF 195 + D + + E ++ S P +H C P + V + + + Sbjct: 137 RLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIY 196 Query: 196 YKFHSLYQTECIHSLKITSSNIKHLIVSQN-GER---LAINCSDRTIRQYEISIDDENSA 251 + L S I+ + + + G +A C D IR ++I+ A Sbjct: 197 QRGKDGKL-HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLA 255 Query: 252 VELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGA 311 E +L N S + + ++ + + L+ + Sbjct: 256 SEESL----------TNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDH 305 Query: 312 EEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 E+ ++W+ + S G + G V +W Sbjct: 306 NGEVWSVSWNLTGTILSSAG-DDGKVRLWKA 335 Score = 57.6 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 51/333 (15%), Positives = 104/333 (31%), Gaps = 56/333 (16%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKE----IRFDSPIWGCQWLDA 125 H + + + GR + T S D IK++ L K + + DS I W Sbjct: 9 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 68 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH--PNI 183 + +A+ + + + DP S +L + D L Sbjct: 69 EYGRIIASASYDKTVKLWE--EDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 126 Query: 184 IIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 + + G L Y + S+++ ++ + L+I ++ + + Sbjct: 127 LACLGNDGILRLYDA-------------LEPSDLRSWTLTSEMKVLSIPPANHLQSDFCL 173 Query: 244 SIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGT 303 S + E ++ L+ I + VA+ Sbjct: 174 SWCPSRFSPEKL-------AVSALEQAIIYQRGKDGKLHVAA------------------ 208 Query: 304 LVRVLEGAEEELIDINWDFYSMSI---VSNGFESGNVYVWSVVIPPKWSALAPDFEEVEE 360 L G + + I+W ++ G + G + ++ I K S LA EE Sbjct: 209 ---KLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK--ITEKLSPLAS--EESLT 261 Query: 361 NVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDL 393 N + + + D + E++ E+ +L Sbjct: 262 NSNMFDNSADVDMDAQGRSDSNTEEKAELQSNL 294 Score = 48.3 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 34/282 (12%), Positives = 72/282 (25%), Gaps = 61/282 (21%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGN-----MLGAHVRPITSIAWSPD--GRLLLT 89 G +A + + +++ D + C L + S+ ++P G L Sbjct: 70 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 129 Query: 90 SSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLC------VATIFEESDAYVI 143 D ++L+D +PS L+ S + A + F V Sbjct: 130 LGNDGILRLYDALEPS-DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 188 Query: 144 DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP----NIIIVGTSKGWLDFYKF- 198 + + P H ++ +I G G + +K Sbjct: 189 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 248 Query: 199 ------------------------------HSLYQTECIHSLKI------------TSSN 216 S TE L+ + Sbjct: 249 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGE 308 Query: 217 IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEH 258 + + + G L+ D +R ++ + +E + + Sbjct: 309 VWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQ 350 Score = 38.7 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 16/145 (11%), Positives = 44/145 (30%), Gaps = 18/145 (12%) Query: 211 KITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWN 270 + ++ G +A SD+ I+ +++ D N + D + Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELS--------DSWRAHDSS 59 Query: 271 CILFSNNTAEYLVASTHGSSAHELYIW--ETTSGTL-------VRVLEGAEEELIDINWD 321 + + EY S + +W + + L ++ L + + Sbjct: 60 IVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFA 119 Query: 322 F-YSMSIVSNGFESGNVYVWSVVIP 345 + ++ G + ++ + P Sbjct: 120 PAHLGLKLACLGNDGILRLYDALEP 144 Score = 27.9 bits (60), Expect = 9.9, Method: Composition-based stats. Identities = 3/30 (10%), Positives = 13/30 (43%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIY 53 ++ + ++ G L+ +G + ++ Sbjct: 304 DHNGEVWSVSWNLTGTILSSAGDDGKVRLW 333 >4BH6-A nrPDB Length = 308 Score = 80.3 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 31/227 (13%), Positives = 73/227 (32%), Gaps = 18/227 (7%) Query: 18 KLTHTIENPL-RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 K T+ + R CL ++ L G + ++ D+ P + +H + + Sbjct: 95 KCIRTLSGHIDRVACLSWN--NHVLTSGSRDHRILHRDVRMPDPFF---ETIESHTQEVC 149 Query: 77 SIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 + W+ L + D + +++ + S L + + W KR + Sbjct: 150 GLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGG-- 207 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY 196 + D + + + ++S + ++ + Sbjct: 208 --------GTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYN--L 257 Query: 197 KFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 + I LK S + HL +S +G + D T+R +++ Sbjct: 258 TLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 37/278 (13%), Positives = 86/278 (30%), Gaps = 36/278 (12%) Query: 73 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVA 132 TS++W G L + ++++D+ K + W Sbjct: 63 NEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW---------- 112 Query: 133 TIFEESDAYVIDFSNDPVASLLSKSDEKQLS-STPDHGYVLVCTVHTKHPNIIIVGTSKG 191 ++ + S D + H + N + G G Sbjct: 113 -----NNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASG---G 164 Query: 192 WLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAI---NCSDRTIRQYEISIDDE 248 + + I + + +K + S + + +DR ++ + ++ + Sbjct: 165 NDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIK 224 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL 308 S ++ + + W S NT E + + HG S + L +W+ S + +L Sbjct: 225 MSDIDSGSQIC------NMVW-----SKNTNELVTS--HGYSKYNLTLWDCNSMDPIAIL 271 Query: 309 EGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPP 346 +G ++ + + V +G + W + P Sbjct: 272 KGHSFRVLHLTLS-NDGTTVVSGAGDETLRYWKLFDKP 308 >6ELZ-p nrPDB Length = 460 Score = 78.4 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 49/338 (14%), Positives = 113/338 (33%), Gaps = 36/338 (10%) Query: 16 PEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 P ++ N L ++ G +G + +D+ H PI Sbjct: 93 PPSYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSG-----NVQKQYSGHSGPI 147 Query: 76 TSIAWSPDGRLLLTSSRDWSIKLW-----DLSKPSKPLKEIRFDSPIW-----GCQWLDA 125 ++ + + R L+++ D +++LW DL S+ + D + L+ Sbjct: 148 RAVKYISNTR-LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEG 206 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII 185 + V+ ++ ++ S D S + L + N I Sbjct: 207 HKAPVVSIDVSDNS-RILSASYDNSIGFWST-----IYKEMTVVDPLEDINNPN--NKIS 258 Query: 186 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIV-SQNGERLAINCSDRTIRQYEIS 244 K K ++ + + L+ ++ ++ +I S + D TI+ +++ Sbjct: 259 TAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLV 318 Query: 245 IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 304 ++ I +L +L ++A ++ H+ + +S Sbjct: 319 TA---RCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITL-------HDPRV-GASSKVT 367 Query: 305 VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 + L G + + ++ + I+ +G G V VW V Sbjct: 368 QQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDV 405 Score = 71.0 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 37/283 (13%), Positives = 79/283 (27%), Gaps = 56/283 (19%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPG-------------------NMLGAHVRPITSIA 79 L + L ++ +L H P+ SI Sbjct: 156 TRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSID 215 Query: 80 WSPDGRLLLTSSRDWSIKLW--------------DLSKPSKPL--------------KEI 111 S D +L++S D SI W D++ P+ + I Sbjct: 216 VS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTI 274 Query: 112 RFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYV 171 R +P+ + A + + + Y S D + + T Y Sbjct: 275 RRRAPLSLLESHTAPVEQVIFDSTDNTVGY--SVSQDHTIKTWDLVTARCI-DTRTTSYS 331 Query: 172 LVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHS-LKITSSNIKHLIVSQNGERLA 230 L+ N++ G+S + + ++ L + + L E + Sbjct: 332 LLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYIL 391 Query: 231 -INCSDRTIRQYEISIDDENSAVELT---LEHKYQDVINKLQW 269 D T++ +++ + ++ D + ++W Sbjct: 392 CSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKW 434 Score = 55.6 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 20/115 (17%), Positives = 43/115 (37%), Gaps = 6/115 (5%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS-SRDWSIK 97 + LA G + + ++D V L H ++S+ P+ +L S S D ++K Sbjct: 342 NLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVK 401 Query: 98 LWDLSKPSKPLKEIRFDSPIW-----GCQWLDAKRRLCVATIFEESDAYVIDFSN 147 +WD+ S R D + + ++ + + ++ + N Sbjct: 402 VWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVGIISAGQDKKIQINKGDN 456 >5N4A-A nrPDB Length = 771 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 38/204 (18%), Positives = 71/204 (34%), Gaps = 25/204 (12%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKL 98 D A+ C +G++ I + H S+ WS DG L T+ D S+K+ Sbjct: 76 DVFAVACTDGSVKI-----LSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKI 130 Query: 99 WDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSD 158 W + DSP++ W +LC T + S S Sbjct: 131 WS-RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSN--------------VVIKSLSS 175 Query: 159 EKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIK 218 + ++ H V++ + ++II G G YK + + + + Sbjct: 176 NAKQNAWKAHDGVVLKVDWSPINHLIITG---GEDCKYKVWDSF-GRLLFQSGLFDYPVT 231 Query: 219 HLIVSQNGERLAINCSDRTIRQYE 242 + + +GE A+ T++ + Sbjct: 232 SVAWAPSGELFAVGGF-NTLQLCD 254 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 59/206 (28%), Gaps = 24/206 (11%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + L++S G LA +G++ I+ + + L P+ SI W+ D Sbjct: 103 HKGACISLRWSYDGTALATAGEDGSVKIWSRNGM-----LRSTLAQADSPVYSIVWAYDC 157 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 L ++ + LS +K D + W +I Sbjct: 158 DQL-CYCTGSNVVIKSLSSNAKQNAWKAHDGVVLKVDWSPINH-------------LIIT 203 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT 204 D + S + L + Y + + VG + + Sbjct: 204 GGEDCKYKVWD-SFGRLLFQSGLFDYPVTSVAWAPSGELFAVGG----FNTLQLCDRMGW 258 Query: 205 ECIHSLKITSSNIKHLIVSQNGERLA 230 + +I L + + +LA Sbjct: 259 AYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 55.2 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 33/275 (12%), Positives = 76/275 (27%), Gaps = 27/275 (9%) Query: 60 PICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWG 119 + V + H ++ W+ L T S D +I W++ K D+ Sbjct: 2 RLKVKQSSANVHSELTAAVGWNVWNE-LFTCSDDQTIHKWNML-GEPEQKVSTLDAYFTD 59 Query: 120 CQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTK 179 W + A + D S ++ + S H + + Sbjct: 60 MHWYPVSSKKTQAGGTDVFAVACTDGSVKILSR-----TGRVEKSIEGHKGACISLRWSY 114 Query: 180 HPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIR 239 + G + + +L S + ++ + + ++L + Sbjct: 115 DGTALATAGEDGSVKIWS----RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVV- 169 Query: 240 QYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 299 I N+ H D + + + +L+ G + +W+ Sbjct: 170 ---IKSLSSNAKQNAWKAH---DGV------VLKVDWSPINHLI--ITGGEDCKYKVWD- 214 Query: 300 TSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFES 334 + G L+ + + + W GF + Sbjct: 215 SFGRLLFQSGLFDYPVTSVAWAPSGELFAVGGFNT 249 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 31/139 (22%), Positives = 60/139 (43%), Gaps = 12/139 (8%) Query: 209 SLKITSSNIKHLIVSQNG----ERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVI 264 +K +S+N+ + + G L D+TI ++ + + E TL+ + D+ Sbjct: 4 KVKQSSANVHSELTAAVGWNVWNELFTCSDDQTIHKWNMLGEPEQKVS--TLDAYFTDMH 61 Query: 265 NKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYS 324 + + T + VA T GS + I T G + + +EG + I + W + Sbjct: 62 WYPVSSKKTQAGGTDVFAVACTDGS----VKILSRT-GRVEKSIEGHKGACISLRWSYDG 116 Query: 325 MSIVSNGFESGNVYVWSVV 343 ++ + G E G+V +WS Sbjct: 117 TALATAG-EDGSVKIWSRN 134 >3ACP-A nrPDB Length = 417 Score = 75.7 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 60/342 (17%), Positives = 111/342 (32%), Gaps = 53/342 (15%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKL 98 LG G + + D + + AHV IT + + P G L++SS+D +K+ Sbjct: 107 RRFILGTTEGDIKVLD----SNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKI 162 Query: 99 WDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSD 158 W + S P I + + +D R + A++ D L Sbjct: 163 WSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASL-------------DGTIRLWECGT 209 Query: 159 EKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIK 218 + H + H +I + + L +I++S Sbjct: 210 GTTI-----HTFNRKENPHDGVNSIALFVGTDRQLH----------------EISTSKKN 248 Query: 219 HLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNT 278 +L G+ + I + + ++ + L K+ N L + N Sbjct: 249 NLEFGTYGKYVIAGHVSGVITVHNVFSKEQ----TIQLPSKFTCSCNSLTVD-----GNN 299 Query: 279 AEYLVASTHGSSAHELYIWETTSGTL-VRVLEGAEEELIDINWDFYSMSIVSNGFESGNV 337 A Y+ A L W+ S V E I+ + VS+GF++ Sbjct: 300 ANYIYAGYENGM---LAQWDLRSPECPVGEFLINEGTPINNVYFAAGALFVSSGFDTSIK 356 Query: 338 YVWSVVIPPKWSALAPDFEEVEENVDYLEKEDEFDEVDEAEQ 379 ++ P+ A +FE V ++ +F V + E Sbjct: 357 --LDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDES 396 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 50/269 (18%), Positives = 88/269 (32%), Gaps = 24/269 (8%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 + L+F P G+ L + L I+ + L H +T IA Sbjct: 134 AHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSN----PRTLIGHRATVTDIAIIDR 189 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP---IWGCQWLDAKRRLCVATI------ 134 GR +L++S D +I+LW+ + R ++P + R Sbjct: 190 GRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNN 249 Query: 135 --FEESDAYVIDFSNDPVASLLSKSDEKQLSSTPD--HGYVLVCTVHTKHPNIIIVGTSK 190 F YVI V ++ + ++Q P TV + N I G Sbjct: 250 LEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYEN 309 Query: 191 GWLDFYKFHSLYQTEC-IHSLKITSS-NIKHLIVSQNGERLAINCSDRTIRQYEISIDDE 248 G L EC + I I ++ + G + D +I+ +I D E Sbjct: 310 G---MLAQWDLRSPECPVGEFLINEGTPINNVYFAA-GALFVSSGFDTSIKL-DIISDPE 364 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNN 277 + + E V N + + + ++ Sbjct: 365 SERPAIEFETPTFLVSNDDEVSQFCYVSD 393 >4XYI-A nrPDB Length = 430 Score = 74.5 bits (181), Expect = 8e-14, Method: Composition-based stats. Identities = 28/131 (21%), Positives = 56/131 (42%), Gaps = 7/131 (5%) Query: 32 LQFSPCGDYL-ALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGR-LLLT 89 + F+P DYL A A+ + ++D+ R + + L H + ++ WSP +L+T Sbjct: 287 VAFNPFNDYLLATASADHTVALWDL---RRLNQRLHTLEGHEDEVYNVQWSPHDEPILVT 343 Query: 90 SSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY--VIDFSN 147 SS D + +WDLSK + + ++ V+ + + + ++ Sbjct: 344 SSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLAD 403 Query: 148 DPVASLLSKSD 158 D + + S S Sbjct: 404 DNILQIWSPSK 414 Score = 72.2 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 38/297 (12%), Positives = 101/297 (34%), Gaps = 41/297 (13%) Query: 71 HVRPITSIAWSPDG-RLLLTSSRDWSIKLWDLS-KPSKPLKEIRFDSPI--WGCQWLDAK 126 H + + P ++ T + + ++DL+ +P+ + + + + Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 127 RRLC----VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN 182 +AT E++ V D ++ S +S H V+ Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDV-APVSVYHRHTAVVNDLQFHLQHE 248 Query: 183 IIIVGTSKGWLDFYKFHSLY---QTECIHSLKITSSNIKHLIVSQNGERL-AINCSDRTI 238 ++ S + H + +K + + + + L A +D T+ Sbjct: 249 ALLTSVSD--DCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTV 306 Query: 239 RQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 298 +++ ++ L ++D + +QW S + LV S S+ + +W+ Sbjct: 307 ALWDLRRLNQ----RLHTLEGHEDEVYNVQW-----SPHDEPILVTS---STDRRVCVWD 354 Query: 299 TT--------------SGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 + + L+ + G + D++W+ + ++++ + + +WS Sbjct: 355 LSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 Score = 63.7 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 35/244 (14%), Positives = 84/244 (34%), Gaps = 22/244 (9%) Query: 108 LKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPD 167 +++I + + +++ + +AT+ + Y+ D + ++ + L Sbjct: 125 VQKIHHEGDVNKARFMP-QNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTS 183 Query: 168 HGYVLVCTVHTKHPNIIIVGTSKGWLDFYKF-------HSLYQTECIHSLKITSSNIKHL 220 G+ L + GT + + + ++ + L Sbjct: 184 EGFGLGWNFI--QEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDL 241 Query: 221 IVSQNGERLAINCSDR-TIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTA 279 E L + SD T++ ++ + +SA + H+ N + F+ Sbjct: 242 QFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHE-------QPVNGVAFNPFND 294 Query: 280 EYLVASTHGSSAHELYIWETTS-GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVY 338 L + S+ H + +W+ + LEG E+E+ ++ W + I+ V Sbjct: 295 YLLATA---SADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVC 351 Query: 339 VWSV 342 VW + Sbjct: 352 VWDL 355 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 31/226 (13%), Positives = 73/226 (32%), Gaps = 36/226 (15%) Query: 41 LALGCANGALVIYDMDTFRP------ICVPGNMLGAHVRPITSIAWSPDGRLLLTS-SRD 93 LA G + ++ ++D+ P ++ H + + + LLTS S D Sbjct: 198 LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDD 257 Query: 94 WSIKLWDLSKPSKPLKE---IRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPV 150 ++++ D PS + P+ G + D + S D Sbjct: 258 CTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFN------------DYLLATASADHT 305 Query: 151 ASLLSKSD-EKQLSSTPDHGYVLVCTVHTKHPN-IIIVGTSKGWLDFYKFHSLYQT---- 204 +L ++L + H + + H I++ ++ + + + + Sbjct: 306 VALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVE 365 Query: 205 -------ECIHSLKITSSNIKHLIVSQNGER-LAINCSDRTIRQYE 242 E + ++ + L + N + LA D ++ + Sbjct: 366 DSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 Score = 61.8 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 29/183 (15%), Positives = 60/183 (32%), Gaps = 10/183 (5%) Query: 24 ENPLRTECLQFS-PCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 + LQF L + L I+D + AH +P+ +A++P Sbjct: 233 RHTAVVNDLQFHLQHEALLTSVSDDCTLQIHD-TRLPSSSSASQCVKAHEQPVNGVAFNP 291 Query: 83 DGRLL-LTSSRDWSIKLWDLSKPSKPLKEI-RFDSPIWGCQWLDAKRRLCVATIFEESDA 140 L T+S D ++ LWDL + ++ L + + ++ QW + T + Sbjct: 292 FNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSP-HDEPILVTSSTDRRV 350 Query: 141 YVIDFS---NDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 V D S + + + H + + ++ + + + Sbjct: 351 CVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLAD--DNILQ 408 Query: 198 FHS 200 S Sbjct: 409 IWS 411 >5A9Q-7 nrPDB Length = 360 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 45/320 (14%), Positives = 103/320 (32%), Gaps = 39/320 (12%) Query: 61 ICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPS---KPLKEIRFDSPI 117 + V ++ H I +++ GR + T S D S+K+WD S+ + Sbjct: 1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60 Query: 118 WGCQWLDAKRRLCVATIFEESDAYVI-DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTV 176 W W + +A+ + A V + + L +S + ++ D + Sbjct: 61 WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120 Query: 177 HTKH--PNIIIVGTSKGWLDFYKFHSLYQ--TECIHSLKITSSNIKHLIVSQNGER---- 228 ++ ++ G + Y+ + + + + + + R Sbjct: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180 Query: 229 -LAINCSDRT------IRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEY 281 +A+ D + ++ +E + + A TL V + I F+ N Sbjct: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHD------IAFAPNLGRS 234 Query: 282 LVASTHGSSAHELYIW-----ETTSG--------TLVRVLEGAEEELIDINWDFYSMSIV 328 + ++ E TS +V + ++ ++W+ + Sbjct: 235 FHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLA 294 Query: 329 SNGFESGNVYVWSVVIPPKW 348 S+G + G V +W W Sbjct: 295 SSG-DDGCVRLWKANYMDNW 313 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 40/300 (13%), Positives = 98/300 (32%), Gaps = 42/300 (14%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS--PDGRLLLT 89 + F G +A ++ ++ ++D + H + + W+ G++L + Sbjct: 18 VSFDFHGRRMATCSSDQSVKVWD-KSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLAS 76 Query: 90 SSRDWSIKLWD--LSKPSKPLKEIRF----------DSPIWGCQWLDAKRRLCVATIFEE 137 S D + +W+ + + + L+ + + ++ L +AT + Sbjct: 77 CSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSAD 136 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 + + + S S E + H +I VG+ + Sbjct: 137 GIVRIYEAPDVMNLSQWSLQHEISC-KLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMA 195 Query: 198 FHSLYQTEC-------IHSLKITSSNIKHLIVSQNGER----LAINCSDRTIRQY----- 241 +++ +L + + + + N R LAI D +R + Sbjct: 196 KVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPV 253 Query: 242 --EISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 299 E++ + E+ + ++ D N W S N ++AS+ + +W+ Sbjct: 254 RKELTSSGGPTKFEIHIVAQF-DNHNSQVW---RVSWNITGTVLASS--GDDGCVRLWKA 307 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 26/187 (13%), Positives = 58/187 (31%), Gaps = 18/187 (9%) Query: 5 LQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDY-----LALGCANGA------LVIY 53 + + V+ L H I L C+ ++P +A+G + + + I+ Sbjct: 141 IYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIF 200 Query: 54 DMDTFRPICVPGNMLGAHVRPITSIAWSPD-GRLL-LTSSRDWSIKLWDLSKPSKPLKEI 111 + + L P+ IA++P+ GR + + ++++ L K L Sbjct: 201 EYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSS 260 Query: 112 RFDSP--IWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSK---SDEKQLSSTP 166 + I D + + + +D L + K Sbjct: 261 GGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILK 320 Query: 167 DHGYVLV 173 +G + Sbjct: 321 GNGSPVN 327 Score = 31.7 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 24/55 (43%), Gaps = 3/55 (5%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLS--KPSKPLKEIRFDS-PIWG 119 H + ++W+ G +L +S D ++LW + K ++ + P+ G Sbjct: 274 FDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNG 328 >4XFV-A nrPDB Length = 792 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 57/351 (16%), Positives = 107/351 (30%), Gaps = 49/351 (13%) Query: 32 LQFSPCGDYLALGCANGALV-----IYDMDTFRPICVPGNML---GAHVRPITSIAWSPD 83 + +SP G+YL + IYD + + H + + D Sbjct: 395 IAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTD 454 Query: 84 GRLLLTSSRDWSIKLWDLSKP--------------SKPLKEIRFDSPIWGCQWLDAKRRL 129 R ++ + ++ +DL K K P+ G + Sbjct: 455 TR-FVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDA 513 Query: 130 CVATIFEESDAYVIDFSNDPVASLLSKSDEKQLS---------STPDHGYVLVCTVHTKH 180 EE DP++ L E QL HG+ + C + Sbjct: 514 NEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPD 573 Query: 181 PNIIIVGTSKGWLD--FYKFHSLYQ-TECIHSLKITSSNIKHLIVSQNGERLAINCSDRT 237 +I + + S E +L S I L S++G+ L C DR Sbjct: 574 QKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRK 633 Query: 238 IRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 +E +++D L K + ++ W+ V + S + +W Sbjct: 634 WALWERNMEDNTFE----LRFKNEKPHTRIIWDADWAPLEFGNVFVTA---SRDKTVKVW 686 Query: 298 ----ETTSGTLVRVLEGAEEELIDINWD---FYSMSIVSNGFESGNVYVWS 341 E ++ + + I+ ++S G E+G +Y++S Sbjct: 687 RHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 737 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 52/270 (19%), Positives = 94/270 (34%), Gaps = 35/270 (12%) Query: 5 LQDPFAVLKEHP-----------EKLTHTIENPLRTECLQFSPCGDYLALGCANGAL--V 51 + DP ++L+ P ++ + CL SP +A C + + Sbjct: 530 ITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNA 589 Query: 52 IYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLK-- 109 + + + L H IT + +S DG+ LL+ RD LW+ + + Sbjct: 590 VIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELR 649 Query: 110 ---EIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPV---ASLLSKSDEKQLS 163 E IW W + T + V +P S K ++ Sbjct: 650 FKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVT 709 Query: 164 STPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKIT---SSNIKHL 220 + H ++ + +I VG G + Y ++L + E I L + I L Sbjct: 710 AISIHDSMI------REKILISVGLENGEIYLYS-YTLGKFELITQLNEDITPADKITRL 762 Query: 221 IVS---QNGE-RLAINCSDRTIRQYEISID 246 S +NG+ L + SD + R Y ++ + Sbjct: 763 RWSHLKRNGKLFLGVGSSDLSTRIYSLAYE 792 Score = 72.2 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 34/217 (15%), Positives = 75/217 (34%), Gaps = 24/217 (11%) Query: 45 CANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKP 104 A + ++D V L H +T + + PD ++++S D +K+W + Sbjct: 37 GAGKTIALWDPIEPNNKGVYA-TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDY 95 Query: 105 S--KPLKEIRFDS-PIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQ 161 S + ++ I+ S I L ++ + + + L+ Sbjct: 96 SHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISIWRQNIQNDEFGLAHE---- 147 Query: 162 LSSTPDHGYVLVCTVHTKHPN---IIIVGTS--KGWLDFYKFHSLYQTEC--IHSLKITS 214 + + +C +K ++ +G + ++ + +C + L+ Sbjct: 148 -FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHE 206 Query: 215 SNIKHLIVSQN---GERLA-INCSDRTIRQYEISIDD 247 +K L G+ L DR IR + I I+D Sbjct: 207 DWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIND 243 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 39/362 (10%), Positives = 104/362 (28%), Gaps = 60/362 (16%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + C++F P D++ + + I+ T + + + I +++ P Sbjct: 62 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKF-TDYSHLQCIQTIQHYSKTIVALSALP-- 118 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 L+ D +I +W + + + + I + + EE + Sbjct: 119 SLISVGCADGTISIWRQNIQNDEFG-LAHEFTIKKGFFYPL---CLSLSKVEEKKYLLAI 174 Query: 145 FSNDPVASLLSK-------SDEKQLSSTPDHGYVLVCTVH----TKHPNIIIVGTSKGWL 193 + + S + ++ H + T ++ G+ ++ Sbjct: 175 GGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYI 234 Query: 194 DFYKFH--SLYQTECIHSLK----------------------------ITSSNIKHLIVS 223 ++ L S K I L Sbjct: 235 RLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWH 294 Query: 224 QNGERLAINCSDRTIRQYE------ISIDDENSAVELTLEHKYQDVINKLQWNCILFSNN 277 ++ +L +D ++ +E I + + + W+C+ F++ Sbjct: 295 ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHE 354 Query: 278 TAEYLVASTHGSSAHELYIWETTSGTLVRV---LEGAEEELIDINWDFYSMSIVSNGFES 334 ++ + + S +W T + + GA +++ DI W +++ + Sbjct: 355 RMDFFLTNGKTGSW---RMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQ 411 Query: 335 GN 336 Sbjct: 412 TT 413 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 49/272 (18%), Positives = 87/272 (31%), Gaps = 57/272 (20%) Query: 40 YLALGCANGALVIYDM---DTFRPICVPGNMLGAHVRPITSIAWS----PDGRLLLTSSR 92 LA+G N + I D+ C L H + S+A+ P LL + S+ Sbjct: 171 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 230 Query: 93 DWSIKLW---------DLSKPSKPLKE------------------------IRFDSPIWG 119 D I+LW D + SK L + D I Sbjct: 231 DRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISS 290 Query: 120 CQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLL-------SKSDEKQLSSTPDHGYVL 172 QW +++ +L AT ++ V + D + + S + ++T G Sbjct: 291 LQWHESRLQLLAATA--DTSLMVWE--PDETSGIWVCSLRLGEMSSKGASTATGSSGGFW 346 Query: 173 VCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHS---LKITSSNIKHLIVSQNGERL 229 C T + G ++ + + + ++ + S +GE L Sbjct: 347 SCLWFTHERMDFFLTN--GKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYL 404 Query: 230 AINCSDRTIRQYEISIDD-ENSAVELTLEHKY 260 D+T R + I D E+ H++ Sbjct: 405 LATSLDQTTRLFAPWIYDASGRKREIATWHEF 436 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 20/147 (13%), Positives = 54/147 (36%), Gaps = 17/147 (11%) Query: 212 ITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNC 271 I ++ + +++ + +TI ++ + H+ + C Sbjct: 16 IGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVT-------C 68 Query: 272 ILFSNNTAEYLVASTHGSSAHELYIW---ETTSGTLVRVLEGAEEELIDINWDFYSMSIV 328 + F ++ + A S H + IW + + ++ ++ + ++ ++ S++ Sbjct: 69 VRFVPDSDFMVSA----SEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP---SLI 121 Query: 329 SNGFESGNVYVWSVVIPPKWSALAPDF 355 S G G + +W I LA +F Sbjct: 122 SVGCADGTISIWRQNIQNDEFGLAHEF 148 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 10/114 (8%), Positives = 32/114 (28%), Gaps = 13/114 (11%) Query: 184 IIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEI 243 I+ + + + +LK + + + + + + D ++ ++ Sbjct: 33 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 92 Query: 244 SIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 + ++ I + S + V G + + IW Sbjct: 93 TDYSHLQCIQT---------IQHYSKTIVALSALPSLISV----GCADGTISIW 133 >3ODT-A nrPDB Length = 313 Score = 69.5 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 40/234 (17%), Positives = 70/234 (29%), Gaps = 29/234 (12%) Query: 22 TIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIA-W 80 I + L F + G + ++ L AH + Sbjct: 100 LIGHQGNVCSLSF--QDGVVISGSWDKTAKVW------KEGSLVYNLQAHNASVWDAKVV 151 Query: 81 SPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDA 140 S LT+S D +IKLW K K I + + +D Sbjct: 152 SFSENKFLTASADKTIKLWQNDKVIKTFSGI-HNDVVRHLAVVDDGH------------- 197 Query: 141 YVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHS 200 I SND + L+ L + H + C + +I+ S G + S Sbjct: 198 -FISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIV----SCGEDRTVRIWS 252 Query: 201 LYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 + + + +I + NG+ + + SD +R + S E+ Sbjct: 253 KENGSLKQVITLPAISIWSVDCMSNGD-IIVGSSDNLVRIFSQEKSRWASEDEI 305 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 46/260 (17%), Positives = 93/260 (35%), Gaps = 40/260 (15%) Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 + + SRD +++LW + + K L +F D + Sbjct: 30 SKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELL----LFGGKDTMING 85 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT 204 L + S E L + H + ++I G+ +K + Sbjct: 86 ------VPLFATSGEDPLYTLIGHQGNVCSLSF--QDGVVISGSWDKTAKVWK-----EG 132 Query: 205 ECIHSLKITSSNI---KHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQ 261 +++L+ ++++ K + S+N + +D+TI+ ++ N V T + Sbjct: 133 SLVYNLQAHNASVWDAKVVSFSEN--KFLTASADKTIKLWQ------NDKVIKTFSGIHN 184 Query: 262 DVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWD 321 DV+ L + ++ S G + + + +G ++R EG E + I Sbjct: 185 DVVRHLA------VVDDGHFISCSNDG----LIKLVDMHTGDVLRTYEGHESFVYCIKLL 234 Query: 322 FYSMSIVSNGFESGNVYVWS 341 + IVS G E V +WS Sbjct: 235 P-NGDIVSCG-EDRTVRIWS 252 >4E5Z-B nrPDB Length = 436 Score = 69.5 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 28/173 (16%), Positives = 59/173 (34%), Gaps = 13/173 (7%) Query: 25 NPLRTECLQFSPCGD-YLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 + + + +PC D +LA + + I+D+ R L H P+ + +SPD Sbjct: 249 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPVNAACFSPD 307 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPL-------KEIRFDSPIWGCQWLDAKRRLCVATIFE 136 G LLT+ + I+++ S+ PL + + +PI + L V + Sbjct: 308 GARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAA--WHPRYNLIVVGRYP 365 Query: 137 ESDAYVIDFSNDPVASLLSKSDEK--QLSSTPDHGYVLVCTVHTKHPNIIIVG 187 + + + + K P+ + + + Sbjct: 366 DPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASA 418 Score = 55.6 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 43/321 (13%), Positives = 94/321 (29%), Gaps = 21/321 (6%) Query: 28 RTECLQFSPCG-DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-DGR 85 R L + P +A+G G +++++ + IT + ++P + Sbjct: 121 RATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAG--GSITGLKFNPLNTN 178 Query: 86 LLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDF 145 SS + + +L D F I + ++ + + ++ Sbjct: 179 QFYASSMEGTTRLQD------------FKGNILRVFASSDTINIWFCSLDVSASSRMVVT 226 Query: 146 SNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN-IIIVGTSKGWLDFYKFHSLYQT 204 ++ +L D K+L + H + + + + + + + Sbjct: 227 GDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGK 286 Query: 205 ECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVI 264 + S +G RL IR Y S D + +Q + Sbjct: 287 ASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLT 346 Query: 265 N-KLQWNCILFSNNTAEYL---VASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINW 320 K W+ Y S + +++ SG ++ L E I Sbjct: 347 PIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLN 406 Query: 321 DFYSMSIVSNGFESGNVYVWS 341 +F M ++ +WS Sbjct: 407 EFNPMGDTLASAMGYHILIWS 427 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 25/176 (14%), Positives = 59/176 (33%), Gaps = 15/176 (8%) Query: 177 HTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ-NGERLAINCSD 235 H HP+ + VG+ G + + F + I + +I L + N + + + Sbjct: 128 HPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGI-GAGGSITGLKFNPLNTNQFYASSME 186 Query: 236 RTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELY 295 T R ++ + D IN W C L + ++ +V G + + Sbjct: 187 GTTRL-------QDFKGNILRVFASSDTIN--IWFCSLDVSASSRMVVT---GDNVGNVI 234 Query: 296 IWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSAL 351 + L L ++++ + + ++ V +W + ++ Sbjct: 235 LLNMDGKEL-WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASF 289 >5OQL-X nrPDB Length = 630 Score = 68.7 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 39/285 (13%), Positives = 77/285 (27%), Gaps = 42/285 (14%) Query: 20 THTIENPLRT-ECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSI 78 T + L+ ++ S G ++ G A+ LV+Y+ +PI H +T + Sbjct: 239 DKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPI----KAFTQHRDAVTGL 294 Query: 79 AWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEES 138 A+ L + S+D ++K+W L + + I L + CV+ + Sbjct: 295 AFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDAL--GQERCVSVGARDR 352 Query: 139 DAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH-----------PNIIIVG 187 A + + ++ + H ++ + G Sbjct: 353 TARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTG 412 Query: 188 TSKGWLDFYKFHSLYQTECIHSLKITSSN------------------------IKHLIVS 223 + G L + I I L Sbjct: 413 SDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTL 472 Query: 224 QNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQ 268 + + D IR + +S D L + N Sbjct: 473 PYSDLIFSGSWDGCIRVWRLSEDKRKLEAVGILGVGSETCENSTN 517 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 30/238 (12%), Positives = 67/238 (28%), Gaps = 24/238 (10%) Query: 105 SKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSS 164 K + + + + + T Y + D + +L Sbjct: 146 GKVYRRLASELAFDKATYTQFRWNSGTVTSVAVCPPYAYTTTKDGYLTKW------KLQD 199 Query: 165 TPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ 224 P + + K P + + + + + SQ Sbjct: 200 LPKNQWPQTTKKKPKKPPAPPKKRPERICFAKADARKANDK---TYQGHLKAPLVVKASQ 256 Query: 225 NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVA 284 +G+ + +D+ + Y + + ++ +H+ D + L + + Sbjct: 257 DGKFVVTGGADKRLVVYNAA---DLKPIKAFTQHR--DAVTGLAFR-------RGTNQLY 304 Query: 285 STHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 S S + +W V L G ++E++DI+ VS G W V Sbjct: 305 SC--SKDRTVKVWSLDELAYVETLFGHQDEILDID-ALGQERCVSVGARDRTARYWKV 359 >5WLC-LJ nrPDB Length = 513 Score = 68.3 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 38/220 (17%), Positives = 70/220 (31%), Gaps = 24/220 (10%) Query: 29 TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 F G L G A G + +YD R I + N H +T + D ++L Sbjct: 84 VYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINAST-HPTHVTKFH-TQDNKILA 141 Query: 89 TSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 148 T+S D +LWD+S +P E+ A + + + V S D Sbjct: 142 TASDDRVTRLWDISNAYEPQLELTG-----------ATDYVRTLSFIPAAPHLVATGSYD 190 Query: 149 PVASLLSKSDEKQLSSTP-DHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECI 207 + L +H + + I+ G + +K L + + Sbjct: 191 GLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGG-----NNFKVWDLTSNKKL 245 Query: 208 HSLKITSSNIKHLIV-----SQNGERLAINCSDRTIRQYE 242 + + + L S L + D ++ ++ Sbjct: 246 YERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFD 285 Score = 41.4 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 19/122 (15%), Positives = 42/122 (34%), Gaps = 9/122 (7%) Query: 42 ALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAW-----SPDGRLLLTSSRDWSI 96 + C ++D+ + + + GN A +T + + SP L+ SS D + Sbjct: 226 IVSCGGNNFKVWDLTSNKKLYERGNFNKA----VTCLDYVENFDSPMQSALIASSLDGHV 281 Query: 97 KLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSK 156 K++D + +F P+ C + + + S + + K Sbjct: 282 KVFDPLDNFQVKFGWKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKKEKRSSDK 341 Query: 157 SD 158 + Sbjct: 342 EN 343 >5FA5-B nrPDB Length = 367 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 35/236 (14%), Positives = 84/236 (35%), Gaps = 19/236 (8%) Query: 41 LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 100 + + +GA+ ++++D + V H +++++ G ++ S+D IK+WD Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 101 LSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEK 160 L++ + + + + E++ + D AS + S Sbjct: 179 LAQQVVLSSYRAHAAQVTCVAASP-HKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPG 237 Query: 161 QLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHL 220 L + H + + + G G + T C+ S + S + L Sbjct: 238 YLPT--------SLAWHPQQSEVFVFGDENGTVSLV---DTKSTSCVLSSAVHSQCVTGL 286 Query: 221 IVSQ-NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFS 275 + S + LA D ++ + S+ + + ++D + W+ + S Sbjct: 287 VFSPHSVPFLASLSEDCSLAVLDSSLSELFRS------QAHRDFVRDATWSPLNHS 336 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 31/162 (19%), Positives = 54/162 (33%), Gaps = 21/162 (12%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 E+ + G G + + ++D+ V + AH +T +A SP Sbjct: 148 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQ----VVLSSYRAHAAQVTCVAASPH 203 Query: 84 -GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIW---GCQWLDAKRRLCVATIFEESD 139 + L+ S D I LWD P KP +I +P + W + + V Sbjct: 204 KDSVFLSCSEDNRILLWDTRCP-KPASQIGCSAPGYLPTSLAWHPQQSEVFVF------- 255 Query: 140 AYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 181 + SL+ + S+ H + V + H Sbjct: 256 -----GDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHS 292 >5TF2-A nrPDB Length = 407 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 33/206 (16%), Positives = 71/206 (34%), Gaps = 23/206 (11%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 + F+ LA G +G + ++ + + + AH I +A PDG+ L+T Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLE----FKAHEGEIEDLALGPDGK-LVTVG 232 Query: 92 RDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFS----- 146 RD +W + L + + P + + + C + A + F+ Sbjct: 233 RDLKASVWQKDQLVTQL-HWQENGPTFSS--TPYRYQACRFGQVPDQPAGLRLFTVQIPH 289 Query: 147 ------NDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHS 200 + S+ L + V+ C ++ + +GT G + Y S Sbjct: 290 KRLRQPPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFS 349 Query: 201 LYQTECIHSLKITSSN-IKHLIVSQN 225 L +C++ ++ + + Sbjct: 350 L---QCLYYVREAHGIVVTDVAFLPE 372 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 24/172 (13%), Positives = 50/172 (29%), Gaps = 12/172 (6%) Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 + ++ D LL T D +++W + K L+ + I + + T+ + Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK---LVTVGRD 234 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV--CTVHTKHPNIIIVGTSKGWLD- 194 A V + V L + + SSTP + Sbjct: 235 LKASVWQ-KDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLR 293 Query: 195 -----FYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 + + + + L VS++G L + ++ Y Sbjct: 294 QPPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIY 345 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 13/93 (13%), Positives = 31/93 (33%), Gaps = 4/93 (4%) Query: 150 VASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHS 209 L + + + + + ++ G + G++ +K SL E + Sbjct: 153 EGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSL---EKVLE 209 Query: 210 LKITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 K I+ L + +G+ L D ++ Sbjct: 210 FKAHEGEIEDLALGPDGK-LVTVGRDLKASVWQ 241 >4J0X-A nrPDB Length = 451 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 49/336 (14%), Positives = 104/336 (30%), Gaps = 66/336 (19%) Query: 15 HPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRP 74 E T + + SP G Y+ G + L+++ ++ P+ V Sbjct: 103 KHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT--KDRRGE 160 Query: 75 ITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATI 134 + S+A+ + L S D+ I+ + +++ S+ + L +R CV Sbjct: 161 VLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMER--CVTVG 218 Query: 135 FEESDAYVIDF------------SNDPVASLLSKSDEK---------------QLSSTPD 167 + A + + K + K L Sbjct: 219 ARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEG 278 Query: 168 HGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGE 227 V+ I G+ G + SL + + I + +I + + Sbjct: 279 SIDVVSMVDDF----HFITGSDNGNICL---WSLAKKKPIFTERIAHGILPEPSFN---- 327 Query: 228 RLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTH 287 +IS + + + L+ K ++ W L++ + ++ Sbjct: 328 --------------DISGETDEELRKRQLQGK--KLLQPF-WITSLYAIPYSNVFIS--- 367 Query: 288 GSSAHELYIWETT----SGTLVRVLEGAEEELIDIN 319 GS + L +W+ + S L+ L GA+ + I Sbjct: 368 GSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQ 403 Score = 49.1 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 32/176 (18%), Positives = 63/176 (35%), Gaps = 15/176 (8%) Query: 151 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL 210 A + S + ++T H ++ + ++ G L + SL + I + Sbjct: 96 AKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT- 154 Query: 211 KITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWN 270 K + L +N ++L +C+D IR Y I ++ S +E+ H D++ Sbjct: 155 KDRRGEVLSLAFRKNSDQLYASCADFKIRTYSI---NQFSQLEILYGH--HDIVED---- 205 Query: 271 CILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMS 326 S E V G+ +W+ T + G E + + W + Sbjct: 206 ---ISALAMERCVT--VGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAK 256 Score = 32.5 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 11/71 (15%), Positives = 24/71 (33%), Gaps = 7/71 (9%) Query: 36 PCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG-------RLLL 88 P + G +G+L ++ + L +T I G R+L Sbjct: 360 PYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILA 419 Query: 89 TSSRDWSIKLW 99 + +++ + W Sbjct: 420 SIAKEHRLGRW 430 >2AQ5-A nrPDB Length = 402 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 48/257 (18%), Positives = 89/257 (34%), Gaps = 25/257 (9%) Query: 3 ILLQDPFAVLKEHPEKLTHTIENPLRTECLQFSP-CGDYLALGCANGALVIYDMDTFR-- 59 + L V K P HT + + P + +A G + ++++++ Sbjct: 62 LPLGKTGRVDKNVPLVCGHT----APVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLV 117 Query: 60 -PICVPGNMLGAHVRPITSIAWSPDGR-LLLTSSRDWSIKLWDLSKPSKPLKEIR--FDS 115 P+ P L H + + +AW P + +LL++ D I +WD+ + L Sbjct: 118 LPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPD 177 Query: 116 PIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCT 175 I+ W +C T + VI+ V + + E + P H Sbjct: 178 TIYSVDWSRDGALIC--TSCRDKRVRVIEPRKGTVVAEKDRPHE---GTRPVH------A 226 Query: 176 VHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLK--ITSSNIKHLIVSQNGERLAINC 233 V I+ G S+ E SL+ TSS + + + + Sbjct: 227 VFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCG 286 Query: 234 S-DRTIRQYEISIDDEN 249 D +IR +EI+ + Sbjct: 287 KGDSSIRYFEITSEAPF 303 Score = 57.2 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 28/236 (11%), Positives = 70/236 (29%), Gaps = 27/236 (11%) Query: 32 LQFSPCGDYLAL---GCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG-RLL 87 +P ++AL GA ++ + + ++ H P+ IAW P ++ Sbjct: 40 CAVNPK--FMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVI 97 Query: 88 LTSSRDWSIKLWDLSKPSKPL-------KEIRFDSPIWGCQWLDAKRRLCVATIFEESDA 140 + S D ++ +W++ L + W + + ++ + Sbjct: 98 ASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDN-VI 156 Query: 141 YVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHS 200 V D L H + ++ +I + + Sbjct: 157 LVWDVGTGAAVLTLGPDV---------HPDTIYSVDWSRDGALICTSCRDKRVRVIEPRK 207 Query: 201 LYQTECIHSLKITSSNIKHLIVSQNGERLAIN---CSDRTIRQYEISIDDENSAVE 253 + + + VS G+ L S+R + ++ +E +++ Sbjct: 208 GTVVAEKDRPHEGTRPVHAVFVS-EGKILTTGFSRMSERQVALWDTKHLEEPLSLQ 262 Score = 44.5 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 28/76 (36%), Gaps = 7/76 (9%) Query: 286 THGSSAHELYIWETTSGTLVR-------VLEGAEEELIDINWDFYSMSIVSNGFESGNVY 338 GS + +WE G LV LEG + + + W + +++ + + Sbjct: 98 ASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVIL 157 Query: 339 VWSVVIPPKWSALAPD 354 VW V L PD Sbjct: 158 VWDVGTGAAVLTLGPD 173 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 39/90 (43%), Gaps = 4/90 (4%) Query: 257 EHKYQDV-INKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLE---GAE 312 + Y+DV +++ W+ + N + L + +G + + + G Sbjct: 22 DQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHT 81 Query: 313 EELIDINWDFYSMSIVSNGFESGNVYVWSV 342 ++DI W ++ +++++G E V VW + Sbjct: 82 APVLDIAWCPHNDNVIASGSEDCTVMVWEI 111 >1PI6-A nrPDB Length = 615 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 37/248 (14%), Positives = 86/248 (34%), Gaps = 29/248 (11%) Query: 12 LKEHPEKLTHTIENPLRTEC----LQFSPC-GDYLALGCANGALVIYDMDTFRPICVPGN 66 + P K + + + ++FSP G+++ ++ + +D + + + Sbjct: 188 YQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIED 247 Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 I +++W D + T D +I++WD++ K W Sbjct: 248 DQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQK--------WTLDKQQLG 298 Query: 127 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 186 + + + +I S D + ++ L + H + +I Sbjct: 299 NQQV--GVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LIS 352 Query: 187 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISID 246 G+ G + + S++Q S+ I L S+ E +I D T++ I+ Sbjct: 353 GSYDGRIMEWSSSSMHQD--------HSNLIVSLDNSKAQEYSSI-SWDDTLKVNGITKH 403 Query: 247 DENSAVEL 254 + S ++ Sbjct: 404 EFGSQPKV 411 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 56/328 (17%), Positives = 112/328 (34%), Gaps = 47/328 (14%) Query: 40 YLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 99 + +G L Y++ + + H + IT++ +P L++ S D I W Sbjct: 311 RIISLSLDGTLNFYELGHDEVL----KTISGHNKGITALTVNP----LISGSYDGRIMEW 362 Query: 100 DLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVA---TIFEESDAYVIDFSNDPVASLLSK 156 S + + I A+ ++ T+ S VAS + Sbjct: 363 SSSSMHQD-----HSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANND 417 Query: 157 SDEKQLSSTPD-------HGYVLVCTVHTKHP-------NIIIVGTSKGW-LDFYKFHSL 201 L++ D G ++ N + VG +G + +K L Sbjct: 418 GFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDL 477 Query: 202 Y-QTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKY 260 + L+ S I +S + +A I Y++ V+ + Sbjct: 478 EVSFDLKTPLRAKPSYI---SISPSETYIAAGDVMGKILLYDLQS----REVKTSRWAFR 530 Query: 261 QDVINKLQWNCILFSNNTAEY---LVASTHGSSAHELYIWETTSG-TLVRVLEGAEEELI 316 IN + W N E LVA+ GS ++I+ +++ L ++ + Sbjct: 531 TSKINAISWKPAEKGANEEEIEEDLVAT--GSLDTNIFIYSVKRPMKIIKALNAHKDGVN 588 Query: 317 DINWDFYSMSIVSNGFESGNVYVWSVVI 344 ++ W+ ++VS+G + W+VV+ Sbjct: 589 NLLWE-TPSTLVSSG-ADACIKRWNVVL 614 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 49/296 (16%), Positives = 88/296 (29%), Gaps = 42/296 (14%) Query: 28 RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH-VRPITSIAWSP--DG 84 T L + P + +A C + + +D P H +T++ +SP Sbjct: 20 FTTHLSYDPTTNAIAYPCG-KSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGS 78 Query: 85 RLLLTSSRDWSIKLW----DLSKPSKPLKEIR----FDSPIWGCQWLDAKRRLCVATIFE 136 + L + + +W D S + PI W RRLCV Sbjct: 79 QYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGR 138 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFY 196 ++ I L H + H K + T G Sbjct: 139 DNFGVFIS---------WD--SGNSLGEVSGHSQRINAC-HLKQSRPMRSMTV-GDDGSV 185 Query: 197 KFHSLYQTECIHSLKITSSN---IKHLIVSQN-GERLAINCSDRTIRQYEISIDDENSAV 252 F+ + S + ++ + S + GE + SDR I ++ + + Sbjct: 186 VFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYI 245 Query: 253 ELTLEHKYQDVINKLQW-NCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRV 307 E + Q I L W + F+ A + +W+ T+ V+ Sbjct: 246 E-DDQEPVQGGIFALSWLDSQKFATVGA-----------DATIRVWDVTTSKCVQK 289 Score = 37.9 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 49/122 (40%), Gaps = 15/122 (12%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP--------- 82 + SP Y+A G G +++YD+ + R + I +I+W P Sbjct: 494 ISISPSETYIAAGDVMGKILLYDLQS-REVKTSRWAFR--TSKINAISWKPAEKGANEEE 550 Query: 83 -DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 + L+ T S D +I ++ + +P K +K + ++ G L + + + ++ Sbjct: 551 IEEDLVATGSLDTNIFIYSVKRPMKIIKAL--NAHKDGVNNLLWETPSTLVSSGADACIK 608 Query: 142 VI 143 Sbjct: 609 RW 610 >4U1E-I nrPDB Length = 347 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 40/260 (15%), Positives = 90/260 (34%), Gaps = 46/260 (17%) Query: 67 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 L H RP+T + ++ +G LL + S+D S +W + IW Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDV---- 60 Query: 127 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII- 185 + Y + S D L S+ + +++ + + N + Sbjct: 61 ---------DCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPV-PVKRVEFSPCGNYFLA 110 Query: 186 ----VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLI------------VSQNGERL 229 V + G ++ Y+ T + K++ I +I S G+ + Sbjct: 111 ILDNVMKNPGSINIYEIERDSATHELT--KVSEEPIHKIITHEGLDAATVAGWSTKGKYI 168 Query: 230 AINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGS 289 D I +Y++S + E + ++ I+ +Q FS + ++ + S Sbjct: 169 IAGHKDGKISKYDVSNNYE----YVDSIDLHEKSISDMQ-----FSPDLTYFITS----S 215 Query: 290 SAHELYIWETTSGTLVRVLE 309 ++ + ++ +++ E Sbjct: 216 RDTNSFLVDVSTLQVLKKYE 235 Score = 64.9 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 46/249 (18%), Positives = 87/249 (34%), Gaps = 40/249 (16%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCAN-----GALVIYDMDTF-------RPICVPG 65 + T ++P+ + ++FSPCG+Y N G++ IY+++ + P Sbjct: 85 QCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPI 144 Query: 66 NMLGAHVR--PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWL 123 + + H T WS G+ ++ +D I +D+S + + Sbjct: 145 HKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVS------------NNYEYVDSI 192 Query: 124 DAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNI 183 D + F Y I S D + L+ S + L + L V T Sbjct: 193 DLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKY-ETDCPLNTAVITPLKEF 251 Query: 184 IIVGT------------SKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAI 231 II+G ++G + +H +++ E + + + +S G A Sbjct: 252 IILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRV-QGHFGPLNTVAISPQGTSYAS 310 Query: 232 NCSDRTIRQ 240 D IR Sbjct: 311 GGEDGFIRL 319 Score = 51.8 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 42/303 (13%), Positives = 86/303 (28%), Gaps = 50/303 (16%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKL 98 Y G A+ ++ ++D+ + + + + P+ + +SP G L + D +K Sbjct: 65 KYCVTGSADYSIKLWDVSNGQCVATWKSPV-----PVKRVEFSPCGNYFL-AILDNVMK- 117 Query: 99 WDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSD 158 + + D L+K Sbjct: 118 -------------------------------------NPGSINIYEIERDSATHELTKVS 140 Query: 159 EKQLSSTPDH--GYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSN 216 E+ + H + II G G + Y + E + S+ + + Sbjct: 141 EEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSN--NYEYVDSIDLHEKS 198 Query: 217 IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN 276 I + S + + D ++S E VI L+ IL Sbjct: 199 ISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCP-LNTAVITPLKEFIILGGG 257 Query: 277 NTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGN 336 A+ + ++ E + + ++G L + S S G E G Sbjct: 258 QEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGG-EDGF 316 Query: 337 VYV 339 + + Sbjct: 317 IRL 319 Score = 31.7 bits (70), Expect = 0.57, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 40/113 (35%), Gaps = 10/113 (8%) Query: 289 SSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVI---P 345 S +W + +G + L+G + I+ D ++ G ++ +W V Sbjct: 29 SKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFT-KYCVTGSADYSIKLWDVSNGQCV 87 Query: 346 PKWSALAPDFEEVEENVDYLEKEDEF-DEVDEAEQQQGLEQEEEIAIDLRTRE 397 W + P + V++ + F +D + G EI D T E Sbjct: 88 ATWKSPVP-----VKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHE 135 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 16/36 (44%) Query: 68 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSK 103 + H P+ ++A SP G + D I+L K Sbjct: 289 VQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEK 324 >5YZG-2 nrPDB Length = 646 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 35/260 (13%), Positives = 82/260 (31%), Gaps = 39/260 (15%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 + C + D++ +G + + V +H+ I SIA S + Sbjct: 91 DVITHVVCTK----TDFIITASHDGHVKFWKKIEEGIEFVKH--FRSHLGVIESIAVSSE 144 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE---SDA 140 G L + D ++K++D+ + ++ C+W+ + E Sbjct: 145 GALFCSVGDDKAMKVFDVVNFD-MINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKI 203 Query: 141 YVIDFSNDPVASLLSKSDEKQLSSTPD-HGYVLVCTVHTKHPNIIIVGTSKGWLDFYKF- 198 ++ D D + L H L ++ G ++++ Sbjct: 204 FIYDGRGD----------NQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGP 253 Query: 199 -----------HSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYE----- 242 ++ + + S +G+++A SDR +R + Sbjct: 254 PHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGK 313 Query: 243 -ISIDDENSAVELTLEHKYQ 261 + + DE+ ++ L+ Q Sbjct: 314 LMRVFDESLSMFTELQQMRQ 333 >4PSX-B nrPDB Length = 401 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 44/303 (14%), Positives = 100/303 (33%), Gaps = 45/303 (14%) Query: 18 KLTHTIENPLRTECLQFSP-CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 ++T E+ ++ P + +A G +Y + L H Sbjct: 110 RITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG-----LQSTLKFHKDNGY 164 Query: 77 SIAWSP--DGRLLLTSSRDWSIKLWDLSKPSKPLKEIR-----FDSPIWGCQWLDAKRRL 129 ++++S GRLL + S D ++ LW++ P K +R I +W + + L Sbjct: 165 ALSFSTLVKGRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDL 223 Query: 130 CVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTS 189 T+ E+S + D + K N++ Sbjct: 224 F-GTVSEDSLLKINDVRANNTT----IDTVKCPQPFN------TLAFSHHSSNLLAAAGM 272 Query: 190 KGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINC-SDRTIRQYEISIDDE 248 ++ Y ++ E +H + + +L S + + + ++ SD + +++ Sbjct: 273 DSYVYLYDLRNMK--EPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGA 330 Query: 249 NSAVE---------LTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 299 + + + ++ +N N +LVAS + L +W+ Sbjct: 331 EQTPDDAEDGVPELIMVHAGHRSSVNDFDLN------PQIPWLVASAE--EENILQVWKC 382 Query: 300 TSG 302 + Sbjct: 383 SHS 385 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 32/241 (13%), Positives = 78/241 (32%), Gaps = 48/241 (19%) Query: 146 SNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP-NIIIVGTSKGWLDFYKFHSLYQT 204 + +SL + ++++ +H + + NI+ +G Y Sbjct: 95 GEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYS----RSE 150 Query: 205 ECIHSLKITSSNIKHLIVSQNGE-RLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 +LK N L S + RL D T+ +E+ + + T + D+ Sbjct: 151 GLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDI 210 Query: 264 INKLQW--------------------------------------NCILFSNNTAEYLVAS 285 IN +W N + FS++++ L A+ Sbjct: 211 INDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAA 270 Query: 286 THGSSAHELYIWETTS-GTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVI 344 +Y+++ + + + G E+ + ++ + + +V + + +W + Sbjct: 271 ---GMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 Query: 345 P 345 Sbjct: 328 I 328 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 32/224 (14%), Positives = 68/224 (30%), Gaps = 38/224 (16%) Query: 139 DAYVIDFSNDPVASLLSKSDE----KQLSSTPD-HGYVLVCTVHTKHPNIIIVGTSKGWL 193 ++ S+D +L K + + D H ++ + + Sbjct: 173 KGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLF--GTVSED 230 Query: 194 DFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINC-SDRTIRQYEISIDDENSAV 252 K + + L S + L D + Y++ + Sbjct: 231 SLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL------RNM 284 Query: 253 ELTLEH--KYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET----------- 299 + L H ++D +N L+ FS + +V+S S + L +W+ Sbjct: 285 KEPLHHMSGHEDAVNNLE-----FSTHVDGVVVSS---GSDNRLMMWDLKQIGAEQTPDD 336 Query: 300 ---TSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 340 L+ V G + D + + +V++ E + VW Sbjct: 337 AEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 >2PM9-A nrPDB Length = 416 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 42/338 (12%), Positives = 114/338 (33%), Gaps = 43/338 (12%) Query: 91 SRDWSIKLWDL--SKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 148 S D S++LW L + KP+ ++ DS W +A + + + Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKFNDLDWS--HNNKIIAGALDNGSLELYSTNEA 99 Query: 149 PVASLLSKSDEKQLSSTPDHGYVLVCTVHTK-HPNIIIVGTSKGWLDFYKFHSLYQTECI 207 A ++ +H + N++ G + G + + + ++ Sbjct: 100 NNAI-------NSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSN 152 Query: 208 HS------LKITSSNIKHLIVSQN-GERLAINCSDRTIRQYEISIDDENSAVELTLEHKY 260 ++ + + L +Q+ A S +++ + L + Sbjct: 153 YTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKA----KKEVIHLSYTS 208 Query: 261 QDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL-VRVL-EGAEEELIDI 318 + K Q + + + + + +T + + IW+ + ++ L +G ++ ++ + Sbjct: 209 PNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSL 268 Query: 319 NWDFYSMSIVSNGFESGNVYVWSVVIPPKWSAL---------------APDF---EEVEE 360 +W ++ + V +W+ + S APD + Sbjct: 269 DWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDN 328 Query: 361 NVDYLEKEDEFDEVDEAEQQQGLEQEEEIAIDLRTREQ 398 ++ ++ + +DE E + ++ E + +RE+ Sbjct: 329 KIEVQTLQNLTNTLDEQETETKQQESETDFWNNVSREE 366 Score = 55.6 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 33/261 (12%), Positives = 72/261 (27%), Gaps = 30/261 (11%) Query: 25 NPLRTECLQFSPC-GDYLALGCANGALVIYDMDTFRPICVPGNMLG-----AHVRPITSI 78 + + ++F+ + LA G NG + I+DM+ L + V + S+ Sbjct: 112 HSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISL 171 Query: 79 AWSPD-GRLLLTSSRDWSIKLWDLSKPSKPLK------EIRFDSPIWGCQWLDAKRRLCV 131 AW+ + ++ +WDL + + + +W Sbjct: 172 AWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVA 231 Query: 132 ATIFEESDAYVIDFSNDPVASLLSKSD-EKQLSST-PDHGYVLVCTVHTKHPNIIIVGTS 189 + NDP + + L + H ++ +++ S Sbjct: 232 TATGSD---------NDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLL--S 280 Query: 190 KGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCS-DRTIRQ---YEISI 245 G + + E + + + L S D I ++ Sbjct: 281 SGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTN 340 Query: 246 DDENSAVELTLEHKYQDVINK 266 + E + D N Sbjct: 341 TLDEQETETKQQESETDFWNN 361 >5K19-A nrPDB Length = 569 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 26/134 (19%), Positives = 50/134 (37%), Gaps = 10/134 (7%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 FSP G +LA +G L +++ D+ + ++ + + WSPDG+ ++T Sbjct: 227 AFSPDGKFLACVSQDGFLRVFNFDS----VELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282 Query: 93 DWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVAS 152 D + +W + S + + T EE D S++ Sbjct: 283 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP------YTTSVEEGDPMEFSGSDEDFQD 336 Query: 153 LLSKSDEKQLSSTP 166 LL ++ S+ Sbjct: 337 LLHFGRDRANSTQS 350 Score = 55.6 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 28/250 (11%), Positives = 75/250 (30%), Gaps = 43/250 (17%) Query: 27 LRTECLQFSPCGD-YLALGCANGALVIYDMDTF-------RPICVPGNMLGAHV------ 72 R C+++ P + + ++G + +Y+++ + G H Sbjct: 150 SRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKST 209 Query: 73 -----------RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 + A+SPDG+ L S+D +++++ + + Sbjct: 210 RNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC 269 Query: 122 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 181 W + Y++ D + ++ S D + ++ H + + Sbjct: 270 WSPDGK-------------YIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT 316 Query: 182 NIIIVGTS---KGWLDFYK--FHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDR 236 + G G + ++ H +++ N R D Sbjct: 317 TSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDT 376 Query: 237 TIRQYEISID 246 + ++++ D Sbjct: 377 QLCLWDLTED 386 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 47/333 (14%), Positives = 96/333 (28%), Gaps = 62/333 (18%) Query: 53 YDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKP-SKPLKEI 111 ++ P+ V L + ++ GR L K DLSKP K + + Sbjct: 40 FNSQGSNPVRVSFVNLNDQSGNGDRLCFNV-GRELYFYIYKGVRKAADLSKPIDKRIYKG 98 Query: 112 RFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYV 171 + + + F +ID + L ++ S Sbjct: 99 TQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSR------- 151 Query: 172 LVCTVHTKHPNIII-VGTSKGWLDFYKFHSLYQTECIH--------SLKITS-------- 214 + C + V S G + Y T H S + + Sbjct: 152 VTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRN 211 Query: 215 ---------SNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVIN 265 + S +G+ LA D +R + + + ++ Sbjct: 212 PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLL----- 266 Query: 266 KLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSM 325 C+ +S + +Y+V G + +W ++ G + + + +D Y+ Sbjct: 267 -----CVCWSPD-GKYIVT---GGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT- 316 Query: 326 SIVSNGFESGNVYVWSVVIPPKWSALAPDFEEV 358 E G+ P ++S DF+++ Sbjct: 317 ----TSVEEGD--------PMEFSGSDEDFQDL 337 >6CB1-s nrPDB Length = 569 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 54/393 (13%), Positives = 119/393 (30%), Gaps = 71/393 (18%) Query: 12 LKEHPEKLTHTIE-NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA 70 L+ P + + + + L P G +LA G +G + ++++ T R + ++ Sbjct: 184 LRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREV-YRTTLIDD 242 Query: 71 HVRP---ITSIAWSPD-GRLLLTSSRDWSIKL-------WDLSKPSKPLKEIRFDSPIWG 119 P I I W+PD +L + +I L +D+ K E F +G Sbjct: 243 EENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFG 302 Query: 120 CQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSS----TPDHGYVLVCT 175 E+ + + + +K +KQL T + Sbjct: 303 TVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKL 362 Query: 176 VHTKHPNIIIV------------------------GTSKGWL-----------------D 194 + + + SKG + Sbjct: 363 SWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQR 422 Query: 195 FYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 + + + L Q + L + + + + G+ L + D+ + +++ + + Sbjct: 423 YVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPY--KT 480 Query: 255 TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLV--RVLEGAE 312 H+ LFS+ + + H + +Y + +V + L G + Sbjct: 481 LRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHAT----VYDDMMKNPMIVPLKKLTGHK 536 Query: 313 E----ELIDINWDFYSMSIVSNGFESGNVYVWS 341 ++D W + S G +W+ Sbjct: 537 VINSLGVLDAIWHPREAWLFSAG-ADNTARLWT 568 >5WLC-SG nrPDB Length = 573 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 49/336 (14%), Positives = 104/336 (30%), Gaps = 66/336 (19%) Query: 15 HPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRP 74 E T + + SP G Y+ G + L+++ ++ P+ V Sbjct: 225 KHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT--KDRRGE 282 Query: 75 ITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATI 134 + S+A+ + L S D+ I+ + +++ S+ + L +R CV Sbjct: 283 VLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMER--CVTVG 340 Query: 135 FEESDAYVIDF------------SNDPVASLLSKSDEK---------------QLSSTPD 167 + A + + K + K L Sbjct: 341 ARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEG 400 Query: 168 HGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGE 227 V+ I G+ G + SL + + I + +I + + Sbjct: 401 SIDVVSMVDDF----HFITGSDNGNICL---WSLAKKKPIFTERIAHGILPEPSFN---- 449 Query: 228 RLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTH 287 +IS + + + L+ K ++ W L++ + ++ Sbjct: 450 --------------DISGETDEELRKRQLQGK--KLLQPF-WITSLYAIPYSNVFIS--- 489 Query: 288 GSSAHELYIWETT----SGTLVRVLEGAEEELIDIN 319 GS + L +W+ + S L+ L GA+ + I Sbjct: 490 GSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQ 525 Score = 47.9 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 63/178 (35%), Gaps = 19/178 (10%) Query: 151 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL 210 A + S + ++T H ++ + ++ G L + SL + I + Sbjct: 218 AKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT- 276 Query: 211 KITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEH--KYQDVINKLQ 268 K + L +N ++L +C+D IR Y I ++ S +E+ H +D+ Sbjct: 277 KDRRGEVLSLAFRKNSDQLYASCADFKIRTYSI---NQFSQLEILYGHHDIVEDISALAM 333 Query: 269 WNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMS 326 C+ T G+ +W+ T + G E + + W + Sbjct: 334 ERCV-------------TVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAK 378 Score = 32.1 bits (71), Expect = 0.45, Method: Composition-based stats. Identities = 11/71 (15%), Positives = 24/71 (33%), Gaps = 7/71 (9%) Query: 36 PCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG-------RLLL 88 P + G +G+L ++ + L +T I G R+L Sbjct: 482 PYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILA 541 Query: 89 TSSRDWSIKLW 99 + +++ + W Sbjct: 542 SIAKEHRLGRW 552 >2P9P-C nrPDB Length = 372 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 35/233 (15%), Positives = 78/233 (33%), Gaps = 32/233 (13%) Query: 29 TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 C ++ +A+ N + IY+ + + V + L H +T + W+PD ++ Sbjct: 11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQV--HELKEHNGQVTGVDWAPDSNRIV 68 Query: 89 TSSRDWSIKLWDL--SKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFS 146 T D + +W L L +R + +W +++ V + + VI Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGS-----GSRVISIC 123 Query: 147 NDPVASLL--SKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFH----- 199 + K +K + ST ++ + ++ G+ + + Sbjct: 124 YFEQENDWWVCKHIKKPIRST------VLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVE 177 Query: 200 ----------SLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYE 242 + E + + + + S NG R+A D T+ + Sbjct: 178 ERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLAD 230 Score = 53.7 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 22/165 (13%), Positives = 57/165 (34%), Gaps = 5/165 (3%) Query: 28 RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 87 C++++P A+G + + I + V ++ + S+ W P+ LL Sbjct: 98 AARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLL 157 Query: 88 LTSSRDWSIKLWD--LSKPSKPLKEIRFDSPIWGCQWLDAKRRLC---VATIFEESDAYV 142 S D+ +++ + + + + S + + + C F + + V Sbjct: 158 AAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRV 217 Query: 143 IDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVG 187 S+D L + +++ L+ +++ G Sbjct: 218 AWVSHDSTVCLADADKKMAVATLASETLPLLAVTFITESSLVAAG 262 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 15/147 (10%), Positives = 52/147 (35%), Gaps = 9/147 (6%) Query: 207 IHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINK 266 +H LK + + + + + R+ +DR + + + + ++ + + Sbjct: 45 VHELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV-R 103 Query: 267 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMS 326 N F+ + +++ + ++ ++ + + ++ ++W S+ Sbjct: 104 WAPNEKKFAVGSGSRVISICYFEQENDWWV-------CKHIKKPIRSTVLSLDWHPNSVL 156 Query: 327 IVSNGFESGNVYVWSVVIPPKWSALAP 353 + + G ++S I AP Sbjct: 157 LAA-GSCDFKCRIFSAYIKEVEERPAP 182 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 14/138 (10%), Positives = 41/138 (29%), Gaps = 9/138 (6%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 E+ + + ++P + + + ++ + R +L + + W+P+ Sbjct: 50 EHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLK-GRTWKPTLVILRINRAA-RCVRWAPN 107 Query: 84 GRLLLTSSRDWSIKLWDLSKPS----KPLKEIRFDSPIWGCQWLDAKRRLCVATIFEES- 138 + S I + + + + S + W L + + Sbjct: 108 EKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCR 167 Query: 139 --DAYVIDFSNDPVASLL 154 AY+ + P + Sbjct: 168 IFSAYIKEVEERPAPTPW 185 >6C0F-s nrPDB Length = 807 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 54/393 (13%), Positives = 119/393 (30%), Gaps = 71/393 (18%) Query: 12 LKEHPEKLTHTIE-NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA 70 L+ P + + + + L P G +LA G +G + ++++ T R + ++ Sbjct: 422 LRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREV-YRTTLIDD 480 Query: 71 HVRP---ITSIAWSPD-GRLLLTSSRDWSIKL-------WDLSKPSKPLKEIRFDSPIWG 119 P I I W+PD +L + +I L +D+ K E F +G Sbjct: 481 EENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFG 540 Query: 120 CQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSS----TPDHGYVLVCT 175 E+ + + + +K +KQL T + Sbjct: 541 TVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKL 600 Query: 176 VHTKHPNIIIV------------------------GTSKGWL-----------------D 194 + + + SKG + Sbjct: 601 SWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQR 660 Query: 195 FYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 + + + L Q + L + + + + G+ L + D+ + +++ + + Sbjct: 661 YVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPY--KT 718 Query: 255 TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLV--RVLEGAE 312 H+ LFS+ + + H + +Y + +V + L G + Sbjct: 719 LRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHAT----VYDDMMKNPMIVPLKKLTGHK 774 Query: 313 E----ELIDINWDFYSMSIVSNGFESGNVYVWS 341 ++D W + S G +W+ Sbjct: 775 VINSLGVLDAIWHPREAWLFSAG-ADNTARLWT 806 >4G56-B nrPDB Length = 357 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 37/259 (14%), Positives = 88/259 (33%), Gaps = 22/259 (8%) Query: 19 LTHTIENPLRTECLQF-SPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 T ++ + + S G +A GA+ ++++ + V H + + Sbjct: 87 CTAGVQTEAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNKFAKYEHDDIVKT 144 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 ++ DG ++ +D+S+K+WDLS+ + S + + + E+ Sbjct: 145 LSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACP-GKDTIFLSCGED 203 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 + D A+ + + + T H + + G G + Sbjct: 204 GRILLWDTRKPKPATRIDFCASDTIPT--------SVTWHPEKDDTFACGDETGNVSLV- 254 Query: 198 FHSLYQTECIHSLKITSSNIKHLIVS-QNGERLAINCSDRTIRQYEISIDDENSAVELTL 256 ++ + + + S NI L S + LA D T+ + + + Sbjct: 255 --NIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS--- 309 Query: 257 EHKYQDVINKLQWNCILFS 275 ++D + + W+ + S Sbjct: 310 ---HRDFVTGVAWSPLDHS 325 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 30/196 (15%), Positives = 65/196 (33%), Gaps = 20/196 (10%) Query: 190 KGWLDFYKFHSLYQTE--CIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDD 247 G + +K E C ++ + VS+ G + + + +EI Sbjct: 69 GGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKG--ILVASDSGAVELWEIL--- 123 Query: 248 ENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRV 307 E L +K+ + + ++ + G + +W+ + +++ Sbjct: 124 ---EKESLLVNKFAKYEHDDIVKTLSVFSDG----TQAVSGGKDFSVKVWDLSQKAVLKS 176 Query: 308 LEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDF---EEVEENVDY 364 E+ + +I + E G + +W P A DF + + +V + Sbjct: 177 YNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPK--PATRIDFCASDTIPTSVTW 234 Query: 365 L-EKEDEFDEVDEAEQ 379 EK+D F DE Sbjct: 235 HPEKDDTFACGDETGN 250 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 22/169 (13%), Positives = 56/169 (33%), Gaps = 20/169 (11%) Query: 184 IIVGTSKGWLDFYKF---HSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQ 240 I+V + G ++ ++ SL + +K L V +G + D +++ Sbjct: 108 ILVASDSGAVELWEILEKESLLVNKFAKYE--HDDIVKTLSVFSDGTQAVSGGKDFSVKV 165 Query: 241 YEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETT 300 +++S + N + + + + G + +W+T Sbjct: 166 WDLS------------QKAVLKSYNAHSSEVNCVAACPGKDTIFLSCG-EDGRILLWDTR 212 Query: 301 SGTLVRVLE--GAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPK 347 ++ ++ + W + G E+GNV + ++ P Sbjct: 213 KPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDS 261 Score = 29.1 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 23/71 (32%), Gaps = 6/71 (8%) Query: 37 CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP-DGRLLLTSSRDWS 95 +LA + + + D D +H +T +AWSP D T D Sbjct: 281 SSPFLASISEDCTVAVLDADFSEVFRDL-----SHRDFVTGVAWSPLDHSKFTTVGWDHK 335 Query: 96 IKLWDLSKPSK 106 + L + Sbjct: 336 VLHHHLPSEGR 346 >6EM1-m nrPDB Length = 807 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 54/393 (13%), Positives = 119/393 (30%), Gaps = 71/393 (18%) Query: 12 LKEHPEKLTHTIE-NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGA 70 L+ P + + + + L P G +LA G +G + ++++ T R + ++ Sbjct: 422 LRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREV-YRTTLIDD 480 Query: 71 HVRP---ITSIAWSPD-GRLLLTSSRDWSIKL-------WDLSKPSKPLKEIRFDSPIWG 119 P I I W+PD +L + +I L +D+ K E F +G Sbjct: 481 EENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFG 540 Query: 120 CQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSS----TPDHGYVLVCT 175 E+ + + + +K +KQL T + Sbjct: 541 TVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKL 600 Query: 176 VHTKHPNIIIV------------------------GTSKGWL-----------------D 194 + + + SKG + Sbjct: 601 SWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQR 660 Query: 195 FYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 + + + L Q + L + + + + G+ L + D+ + +++ + + Sbjct: 661 YVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPY--KT 718 Query: 255 TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLV--RVLEGAE 312 H+ LFS+ + + H + +Y + +V + L G + Sbjct: 719 LRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHAT----VYDDMMKNPMIVPLKKLTGHK 774 Query: 313 E----ELIDINWDFYSMSIVSNGFESGNVYVWS 341 ++D W + S G +W+ Sbjct: 775 VINSLGVLDAIWHPREAWLFSAG-ADNTARLWT 806 >3JB9-S nrPDB Length = 488 Score = 61.4 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 42/213 (19%), Positives = 80/213 (37%), Gaps = 14/213 (6%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 + T +I + LQ P G+YL N I+ + + V + H ITS Sbjct: 287 EPTSSIPIDEKVNFLQAHPSGEYLLAAS-NEKCYIFSLKSQ----VYNITVAQH---ITS 338 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 +A PDG L + + ++ ++ S ++ K SP+ Q+ + L V T ++ Sbjct: 339 LAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTN-DD 397 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 SD ++ D + + + S +LV + I V +SK W + Sbjct: 398 SDIFIWDLRKSELVQKIPLQTKVAAVSLDITSQLLVSSDGETLYVHIYVKSSKSWRCMSQ 457 Query: 198 FHSLYQTECIHSLKITSSNIKHLIVSQNGERLA 230 H + + + + L+ S + + Sbjct: 458 THVSSISNLVWL-----NELHQLLFSTSNGAIL 485 Score = 36.8 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 27/224 (12%), Positives = 60/224 (26%), Gaps = 24/224 (10%) Query: 122 WLDAKRRLCVATIFEESDAYVIDF-SNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH 180 L+ + F + + L L L C T Sbjct: 203 ILENLETESTTSFFPSPENSSFVLCLHKDELLCLDIQSNSTLKIFEGSA--LACCWLTSS 260 Query: 181 PNIIIVGTSKGWLDFYKFHSLYQ--TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTI 238 + + +F S Q E S+ I + L +GE L Sbjct: 261 KIAVATADAISIFEFPVSSSGLQSVGEPTSSIPIDEK-VNFLQAHPSGEYLLAAS----- 314 Query: 239 RQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 298 +L+ + ++ + + ++ +G EL +E Sbjct: 315 ---------NEKCYIFSLKSQVYNITVAQHITSLAVHPDGNLFVAGLENG----ELRFFE 361 Query: 299 TTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 T+SG + + + + +V + ++++W + Sbjct: 362 TSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDL 405 >5CXB-B nrPDB Length = 369 Score = 61.4 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 41/325 (12%), Positives = 97/325 (29%), Gaps = 58/325 (17%) Query: 62 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLK-EIRFDSPIWGC 120 V + H + S+A P G L T D ++++W+L + ++ D + Sbjct: 11 TVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTV 70 Query: 121 QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKS------------DEKQLSSTPDH 168 +W K +A E +I +L S + KQ ++ P Sbjct: 71 RWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPG 130 Query: 169 GYV-------------------------LVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 + + + + G H+L + Sbjct: 131 KEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSK 190 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV 263 + + + L + R+IR Y++ + V+ Sbjct: 191 HLTQIPFRKLNGLAQTASFHPL-RPLFFVATQRSIRCYDLQKLELVKIVQP--------- 240 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHELYIW---ETTSGTLVRVLEGAEEELIDINW 320 +W + + LV GS L +W + ++ + + E + + + Sbjct: 241 --GAKWISSFDVHPGGDNLVV---GSYDKRL-LWHDLDLSNRP-YKTMRFHTEAIRAVRF 293 Query: 321 DFYSMSIVSNGFESGNVYVWSVVIP 345 + + ++ + G++ ++ +P Sbjct: 294 HKGGLPLFADASDDGSLQIFHGKVP 318 Score = 56.4 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 42/363 (11%), Positives = 105/363 (28%), Gaps = 61/363 (16%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + R + P G LA G +G + ++++ T R + L + ++ W P Sbjct: 20 HEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQV--WSVKLNG-DEAVNTVRWRPTK 76 Query: 85 RLL---LTSSRDWSIKL---------WDLSKPSKPLKEIRFDSPIWGCQWL-----DAKR 127 + D + + D + + L + Sbjct: 77 DTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPGK 136 Query: 128 RLCVATIFEESDAYV--------------IDFSNDPVASLLSKSDEKQLSSTPDHGYVL- 172 T E+ + + S + + + H + Sbjct: 137 WARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKHLTQIP 196 Query: 173 --------VCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ 224 + V T + + L + E + ++ + I V Sbjct: 197 FRKLNGLAQTASFHPLRPLFFVATQ----RSIRCYDLQKLELVKIVQPGAKWISSFDVHP 252 Query: 225 NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQW-NCILFSNNTAEYLV 283 G+ L + D+ + +++ + + + H + LF++ + + + Sbjct: 253 GGDNLVVGSYDKRLLWHDLDLSNRPY--KTMRFHTEAIRAVRFHKGGLPLFADASDDGSL 310 Query: 284 ASTHGSSAHELYIWETTSGTL--VRVLEGAEE----ELIDINWDFYSMSIVSNGFESGNV 337 HG ++ + + T+ V++L+G + ++DI+W + G Sbjct: 311 QIFHGKVPND----QLENPTIVPVKMLKGHKVVNKLGVLDIDWHPR-EPWCVSAGADGTA 365 Query: 338 YVW 340 +W Sbjct: 366 RLW 368 >3W15-A nrPDB Length = 368 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 54/149 (36%), Gaps = 25/149 (16%) Query: 22 TIENPLRTECLQFSPCGDYL-ALGCANGALVIYDMDTFRPICVPGNMLGA-------HVR 73 + + L F+ Y+ A G + A+ I+D+ + H Sbjct: 218 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGL 277 Query: 74 PITSIAWSP-DGRLLLTSSRDWSIKLW-DLSKPS--KPLKEIRFDSP------------- 116 I + WSP +L+++S D + ++W DLS + K D+ Sbjct: 278 AIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEF 337 Query: 117 IWGCQWLDAKRRLCVATIFEESDAYVIDF 145 ++G W + VA+ + + +V + Sbjct: 338 VFGADWSLWGKPGYVASTAWDGNLFVWNG 366 Score = 60.3 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 50/321 (15%), Positives = 105/321 (32%), Gaps = 57/321 (17%) Query: 43 LGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRL-LLTSSRDWSIKLWDL 101 + +G L ++D P + H R + S W+ R L+SS D SIK+W Sbjct: 80 VAQGDGTLRLFD---TTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWS- 135 Query: 102 SKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQ 161 R+ + T+ + + A +L K Sbjct: 136 -----------------------PLRKQSLMTLTPRP-LEITKMVDPLNAIILKKKSFTG 171 Query: 162 LSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSS-NIKHL 220 +S + Y + H ++ + G S L + S + + S Sbjct: 172 ISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQN---NFLVHSGLEALTC 228 Query: 221 IVSQNGERL-AINCSDRTIRQYEISIDDEN-SAVELTLEHKYQDVINKLQWNCILFSNNT 278 ++ + A D IR ++I + ++N + + + L + +S + Sbjct: 229 DFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 288 Query: 279 AEYLVASTHGSSAHELYIW-----------------ETTSGTLVRVLEGAEEELIDINWD 321 + L+++++ IW + T G++ E + +W Sbjct: 289 SNILMSASY---DMTCRIWRDLSNDGAKETYKTNSTDATKGSI-FNFTQHSEFVFGADWS 344 Query: 322 FYSMS-IVSNGFESGNVYVWS 341 + V++ GN++VW+ Sbjct: 345 LWGKPGYVASTAWDGNLFVWN 365 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 37/289 (12%), Positives = 85/289 (29%), Gaps = 41/289 (14%) Query: 24 ENPLRTECLQFS-PCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 E+ ++ +G++ I+ + + L IT + P Sbjct: 104 EHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLM----TLTPRPLEITKM-VDP 158 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYV 142 ++L K + + ++ Q+ + L V + S A + Sbjct: 159 LNAIIL--------------KKKSFTGISKNRNCVYQAQFSPHDQNL-VLSCSGNSYASL 203 Query: 143 IDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFH--- 199 D + + L L C + P ++ G + + Sbjct: 204 FDIRLPSGKNQNNFLVHSGL-------EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 256 Query: 200 ----SLYQTECIHSL-KITSSNIKHLIVSQNGERLA-INCSDRTIRQY-EISIDDENSAV 252 L+ + CI+ + I+ + S + + D T R + ++S D Sbjct: 257 KNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETY 316 Query: 253 ELTLEHKYQDVI-NKLQWNCILFSNNTAEYLVASTHGSS--AHELYIWE 298 + + I N Q + +F + + + S+ L++W Sbjct: 317 KTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 53/126 (42%), Gaps = 10/126 (7%) Query: 239 RQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 298 + + + ID VE+ QD + L WN ++ + LVA G+ L +++ Sbjct: 41 KLFILEIDRSGRIVEVN-SFLTQDCLFDLAWN----ESHENQVLVAQGDGT----LRLFD 91 Query: 299 TTSGTL-VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEE 357 TT + + + E E+ NW+ + + G++ +WS + L P E Sbjct: 92 TTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLE 151 Query: 358 VEENVD 363 + + VD Sbjct: 152 ITKMVD 157 >6F1U-h nrPDB Length = 612 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 45/281 (16%), Positives = 89/281 (31%), Gaps = 51/281 (18%) Query: 13 KEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNML--GA 70 K PE + H + +F P + + G +G +V++D + + V L A Sbjct: 296 KTTPEYVFHCQSAVMSATFAKFHP--NLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAA 353 Query: 71 HVRPITSIAW--SPDGRLLLTSSRDWSIKLWDLS-------------KPSKPLKEIRFDS 115 H P+ + + + L++ S D I W L K SK + Sbjct: 354 HTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSF 413 Query: 116 PIWGCQWLDAKRRL-------------CVATIFE------------------ESDAYVID 144 P+ ++ +FE + + Sbjct: 414 PVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVT 473 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTK-HPNIIIVGTSKGWLDFYKFHSLYQ 203 S D L S + K L S D+ + + + HP + G LD + ++ + Sbjct: 474 SSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTE 533 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS 244 + + + + +G +A+ S+ I Y++ Sbjct: 534 VPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVG 574 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 34/293 (11%), Positives = 93/293 (31%), Gaps = 43/293 (14%) Query: 75 ITSIAWSPDGRLLLTSSR----------DWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLD 124 ++ + WS LL +S D +W++ + + +P + Sbjct: 256 VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNM--------KYKKTTPEY---VFH 304 Query: 125 AKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTP------DHGYVLVCTVH- 177 + + AT + V+ + L K+ H + + C Sbjct: 305 CQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVV 364 Query: 178 -TKHPNIIIVGTSKGWLDFYKF----HSLYQTECIHSLKITSSNIKHLIVS-QNGERLAI 231 T++ + +I ++ G + + H E +H + + + + + Sbjct: 365 GTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVA-VTSMSFPVGDVNNFVV 423 Query: 232 NCSDRTIRQYEISIDDENSAVEL-TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSS 290 + ++ + S + + +Q I + + + + + + V S S Sbjct: 424 GSEEGSV----YTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTS---SF 476 Query: 291 AHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 343 + +W T + + E + D+ W ++ + G + +W++ Sbjct: 477 DWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLN 529 Score = 31.7 bits (70), Expect = 0.69, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 33/82 (40%), Gaps = 4/82 (4%) Query: 24 ENPLRTECLQFSPCGDYLALGCANG--ALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS 81 +N + +SP L C +G L +++++ + + + + + W+ Sbjct: 496 DNAGYVYDVMWSPTHPALF-ACVDGMGRLDLWNLNNDTEVPTASISVEGNP-ALNRVRWT 553 Query: 82 PDGRLLLTSSRDWSIKLWDLSK 103 GR + + I ++D+ + Sbjct: 554 HSGREIAVGDSEGQIVIYDVGE 575 >6N8P-A nrPDB Length = 979 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 45/266 (16%), Positives = 91/266 (34%), Gaps = 30/266 (11%) Query: 12 LKEHPEKLTHTIEN--PLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLG 69 LK + T+E+ P + L +SP LA+G +GA+ +Y + + Sbjct: 5 LKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQEN-- 62 Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDL-----SKPSKPLKEIRFDSPIWGC---- 120 +T I P L+T D S+ LW L + + + P Sbjct: 63 ---NAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSAT 119 Query: 121 ---QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDH------GYV 171 L + E + +V+ + S + L P+ + Sbjct: 120 QITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEM 179 Query: 172 LVCTVHTKHP-NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLA 230 + N I++G S+G L + ++ ++S ++++ ++G L Sbjct: 180 VEALQEHPRDPNQILIGYSRG---LVVIWDLQGSRVLYHF-LSSQQLENIWWQRDGRLLV 235 Query: 231 INCSDRTIRQYEISIDDENSAVELTL 256 SD + Q+ +S + + +L Sbjct: 236 SCHSDGSYCQWPVSSEAQQPEPLRSL 261 Score = 51.8 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 53/308 (17%), Positives = 96/308 (31%), Gaps = 29/308 (9%) Query: 10 AVLKEHPEKLTHTIENPLRTECLQFSP-CGDYLALGCANGALVIYDMDTFRPICVPGNML 68 AVL+ PE+ H E LQ P + + +G + G +VI+D+ R V + L Sbjct: 162 AVLQRLPEEARHR-RVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSR---VLYHFL 217 Query: 69 GAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPS---KPLKEIRFDSPIWGCQW--- 122 + +I W DGRLL++ D S W +S + +PL+ + P Sbjct: 218 SSQQLE--NIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRI 275 Query: 123 -LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP 181 R+ TIF+ ++ + ++ G+ ++ Sbjct: 276 LWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAAT 335 Query: 182 NIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSS-NIKHLIVSQNGERLAINCSDRTIRQ 240 + D Y L + E + T+ L + AI CS Sbjct: 336 ----------FDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHH---V 382 Query: 241 YEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETT 300 I + + + + G + W+ + Sbjct: 383 SNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDAS 442 Query: 301 SGTLVRVL 308 G +R+L Sbjct: 443 -GVCLRLL 449 >5M89-A nrPDB Length = 329 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 37/238 (15%), Positives = 74/238 (31%), Gaps = 25/238 (10%) Query: 18 KLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 K+ T++ ++ G + +G A G + +YD H P+T Sbjct: 84 KVERTLDIGEPVTATEW--TGTKVVIGTAKGWVKVYDA------GRESATFQTHAGPVTG 135 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEE 137 +A P GR+L + D S +DL + + D+ + C + Sbjct: 136 LAVHPGGRILASVGVDKSFVFYDLETGERVARGYA-DAALTTCAFHPDGN---------- 184 Query: 138 SDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYK 197 + + + +Q S P G + +++ T KG Sbjct: 185 ---LFAAGTQTGHILVFHTTTLEQAESFP-LGTPIQALAFSENG-FWFAATGKGTSSVTI 239 Query: 198 FHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDR-TIRQYEISIDDENSAVEL 254 F ++ + + + G+ LA T++ Y + + V L Sbjct: 240 FDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRL 297 >5A9Q-0 nrPDB Length = 380 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 60/171 (35%), Gaps = 6/171 (3%) Query: 11 VLKEHPEKLTHTIEN--PLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNML 68 + + ++ TI+N + F + L + G L I+D L Sbjct: 155 LFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSI-GQLKIWDFRQQGNEPSQILSL 213 Query: 69 GAHVRPITSIAWSPDGR-LLLTSSRDWSIKLWDLSKPSKPLKEIR-FDSPIWGCQWLDAK 126 P+ + P+ + ++ T +D + +WD+ + + P+ ++ ++ +W + + Sbjct: 214 TGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSN 273 Query: 127 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVH 177 T E+ + D S D + S+ H VH Sbjct: 274 PEHLF-TCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQANVH 323 Score = 49.1 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 44/286 (15%), Positives = 91/286 (31%), Gaps = 32/286 (11%) Query: 85 RLLLTSSRDW---SIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAY 141 T S D I LW + + F+ + + F + + Sbjct: 30 ETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDI-RHHGDVMDLQFFDQERI 88 Query: 142 VIDFSNDPVASLLSKSDEKQLSS----TPDHGYV---------LVCTVHTKHPNIIIVGT 188 V S V L + + LS T H + CT + I+ Sbjct: 89 VAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVG 148 Query: 189 SKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDE 248 G ++ ++ I + SS + + + E L +N ++ ++ Sbjct: 149 EDGRINLFRADHKEAVRTIDN--ADSSTLHAVTFLRTPEILTVNSI-GQLKIWDFRQQGN 205 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL-VRV 307 + +++ +C+ N + G L IW+ GT+ V + Sbjct: 206 EPS------QILSLTGDRVPLHCVDRHPNQQHVVAT---GGQDGMLSIWDVRQGTMPVSL 256 Query: 308 LEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV--IPPKWSAL 351 L+ E E+ ++++ + + E G+++ W +P K S Sbjct: 257 LKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLF 302 >5AJA-A nrPDB Length = 361 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 36/222 (16%), Positives = 67/222 (30%), Gaps = 40/222 (18%) Query: 30 ECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLT 89 C FS +L LG G L +Y++ + + H IT + S DG LLLT Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEA----SYNCHNSAITHLEPSRDGSLLLT 96 Query: 90 SSRDWS--IKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSN 147 S+ LW + D + + + + + Sbjct: 97 SATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDR----------------VIGTK 140 Query: 148 DPVASLLSKSDEKQLSSTPDHG----YVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQ 203 +A + +L + + Y C +++ L+ + Sbjct: 141 GDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLV--------LNDGVLWDVRS 192 Query: 204 TECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISI 245 + IH + NI + NG + IN +++ Sbjct: 193 AQAIHKFDKFNMNISGV-FHPNGLEVIINT-----EIWDLRT 228 >3JZG-A nrPDB Length = 402 Score = 57.9 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 33/261 (12%), Positives = 80/261 (30%), Gaps = 42/261 (16%) Query: 19 LTHTIENPLRTECLQFSP-CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITS 77 + H + + L+F P + L + AL ++++ T + + G + H + S Sbjct: 144 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV-EGHRDEVLS 202 Query: 78 IAWSPDGRLLLTSSRDWSIKLWDL-----------------SKPSKPLKEIRFDSPIWGC 120 + G +++ D S+KLW + +K ++P + P + Sbjct: 203 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFST 262 Query: 121 QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGY-VLVCTVHTK 179 + + CV + ++ S + + + Sbjct: 263 RDIHRNYVDCVRWL----GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD 318 Query: 180 HPN---------------IIIVGTSKGWLDFYKFH-SLYQTECIHSLKITS--SNIKHLI 221 + ++ +G G L + +L + I+ Sbjct: 319 YSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTS 378 Query: 222 VSQNGERLAINCSDRTIRQYE 242 S++ L C D +I +++ Sbjct: 379 FSRDSSILIAVCDDASIWRWD 399 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 17/182 (9%), Positives = 54/182 (29%), Gaps = 13/182 (7%) Query: 69 GAHVRPITSIAW---SPDGRLLLTSSRD-WSIKLWDLSKPSKPLKEIRFDSPIWGCQWLD 124 H +P+ + + S +G L+ ++ + L++ + IR + Sbjct: 51 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGE----IRLLQSYVDADADE 106 Query: 125 AKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNII 184 S + + + +++ + + HG + + Sbjct: 107 NFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNL 166 Query: 185 IVGTSKGWLDFYKFHSLYQTECIHSL---KITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 ++ SK + ++ + + + GE++ D +++ + Sbjct: 167 LLSVSK--DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 224 Query: 242 EI 243 I Sbjct: 225 RI 226 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 64/194 (32%), Gaps = 27/194 (13%) Query: 163 SSTPDHGYVLVCTVHTKHPN----IIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIK 218 S DH L H ++ + Y+ HS + + S ++ Sbjct: 48 SLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADEN 107 Query: 219 HLIV------SQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCI 272 + + LA+ S IR I ++ + H N + Sbjct: 108 FYTCAWTYDSNTSHPLLAVAGSRGIIR---IINPITMQCIKHYVGHGNAI-------NEL 157 Query: 273 LFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL---EGAEEELIDINWDFYSMSIVS 329 F L++ S H L +W + TLV + EG +E++ ++D I+S Sbjct: 158 KFHPRDPNLLLSV---SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMS 214 Query: 330 NGFESGNVYVWSVV 343 G ++ +W + Sbjct: 215 CGM-DHSLKLWRIN 227 Score = 39.5 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 26/199 (13%), Positives = 66/199 (33%), Gaps = 25/199 (12%) Query: 113 FDSPIWGCQ--WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGY 170 + P++G Q W + V + + + + LL + + + D + Sbjct: 53 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLL----QSYVDADADENF 108 Query: 171 VLVCTVHTKHPNI--IIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ-NGE 227 + + + + V S+G + ++ +CI + I L + Sbjct: 109 YTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM---QCIKHYVGHGNAINELKFHPRDPN 165 Query: 228 RLAINCSDRTIRQYEISIDDENSAVELTLE-HKYQDVINKLQWNCILFSNNTAEYLVAST 286 L D +R + I ++ V + ++D + ++ + E +++ Sbjct: 166 LLLSVSKDHALRLWNIQT---DTLVAIFGGVEGHRDEVLSADYDLL------GEKIMSC- 215 Query: 287 HGSSAHELYIWETTSGTLV 305 H L +W S ++ Sbjct: 216 --GMDHSLKLWRINSKRMM 232 Score = 35.6 bits (80), Expect = 0.038, Method: Composition-based stats. Identities = 18/145 (12%), Positives = 55/145 (37%), Gaps = 8/145 (5%) Query: 202 YQTECIHSLK-ITSSNIKHLIV---SQNGERLAINCSDRTIRQYEISIDDENSAVELTLE 257 Y +C++SLK + + + S+ G+ L T+ +++ + +S E+ L Sbjct: 41 YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFA----TVGSNRVTLYECHSQGEIRLL 96 Query: 258 HKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELID 317 Y D + ++ ++ S + I + ++ G + + Sbjct: 97 QSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINE 156 Query: 318 INWDFYSMSIVSNGFESGNVYVWSV 342 + + +++ + + + +W++ Sbjct: 157 LKFHPRDPNLLLSVSKDHALRLWNI 181 >5A9Q-2 nrPDB Length = 326 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 29/207 (14%), Positives = 62/207 (29%), Gaps = 28/207 (13%) Query: 5 LQDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDY--------LALGCANGALVIYDMD 56 Q+ A ++ K T + +R + + +SP A+ + ++ D Sbjct: 51 FQEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSD 110 Query: 57 TFRPICVPGNMLGAHVRPITSIAWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDS 115 +L H I + + P +G+ + + S D + ++W+L S Sbjct: 111 LQD--KNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLE--GVQTAHFVLHS 166 Query: 116 PIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCT 175 P W E ++ + ++ + S L + Sbjct: 167 PGMSVCWHP------------EETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPL-MS 213 Query: 176 VHTKHPNIIIVGTSKGWLDFYKFHSLY 202 H N VG G + + + Sbjct: 214 AHWCLKNTFKVGAVAG--NDWLIWDIT 238 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 12/139 (8%), Positives = 50/139 (35%), Gaps = 10/139 (7%) Query: 214 SSNIKHLIVSQ----NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQW 269 + + + + L + + + +E + VE + + ++ Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRV 75 Query: 270 NCILFSN----NTAEYLVASTHGSSAHELYIW--ETTSGTLVRVLEGAEEELIDINWDFY 323 + I +S ++ ++ ++ ++ ++ + +VLEG + + + +D Sbjct: 76 DGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPK 135 Query: 324 SMSIVSNGFESGNVYVWSV 342 +++ + +W++ Sbjct: 136 EGQEIASVSDDHTCRIWNL 154 >5WLC-LN nrPDB Length = 776 Score = 57.6 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 82/247 (33%), Gaps = 31/247 (12%) Query: 26 PLRTECLQFS---------PCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPIT 76 P L FS P LA+G +NG + I++ + G R I Sbjct: 43 PATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNP--RNNWFQEMVIEGGKDRSIE 100 Query: 77 SIAWSP---DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + WS + L + + WDL+ IW D++ +L V Sbjct: 101 GLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGC 160 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWL 193 + +ID S P +Q V T+ K + +I G S G + Sbjct: 161 --DNGTVVLIDISGGPGVLEHDTILMRQ--------EARVLTLAWKKDDFVIGGCSDGRI 210 Query: 194 DFYKFH--SLYQTECIHSLKITSSN-----IKHLIVSQNGERLAINCSDRTIRQYEISID 246 + +H++K+ + + +I +++A S +I+ ++ Sbjct: 211 RIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFA 270 Query: 247 DENSAVE 253 N + + Sbjct: 271 TLNQSFK 277 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 38/278 (13%), Positives = 94/278 (33%), Gaps = 22/278 (7%) Query: 17 EKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI- 75 E T + R L + D++ GC++G + I+ + G +L H + Sbjct: 178 EHDTILMRQEARVLTLAWKKD-DFVIGGCSDGRIRIWSAQ--KNDENMGRLL--HTMKVD 232 Query: 76 -----TSIAWS----PDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 126 +++ WS P + + SIK WD + D+ + Sbjct: 233 KAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDN 292 Query: 127 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 186 + A + + + + + + S + L + +C +K + ++ Sbjct: 293 NYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLH---GNDIRAICAYQSKGADFLVS 349 Query: 187 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISID 246 G + L S + K+++V++ +RL ++ S+ T++ + + Sbjct: 350 GGVEKTLVINSLTSFSNGN-YRKMPTVEPYSKNVLVNKE-QRLVVSWSESTVKIWTMGT- 406 Query: 247 DENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVA 284 ++S + + + + S + +V Sbjct: 407 -DSSTEQNYKLVCKLTLKDDQNISTCSLSPDGQVLVVG 443 Score = 48.7 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 41/269 (15%), Positives = 86/269 (31%), Gaps = 24/269 (8%) Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSK--PSKPLKEIRFDSPIWGCQWLDAKR 127 +H I + P L + +I++W+ + + E D I G W + Sbjct: 52 SHKSNINKLT--PSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNG 109 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVG 187 + V + + L + + V+ + + VG Sbjct: 110 ESL----------RLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVG 159 Query: 188 TSKGWLDFYKFHSLYQT-ECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISID 246 G + E L + + L ++ + + CSD IR + + Sbjct: 160 CDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKD-DFVIGGCSDGRIRIWSAQKN 218 Query: 247 DEN--SAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 304 DEN + K + L W+ I + T + + GS + W+ TL Sbjct: 219 DENMGRLLHTMKVDKAKKES-TLVWSVI-YLPRTDQIASGDSTGS----IKFWDFQFATL 272 Query: 305 VRVLEGAEEELIDINWDFYSMSIVSNGFE 333 + + + +++ + D + + S G + Sbjct: 273 NQSFKAHDADVLCLTTDTDNNYVFSAGVD 301 >5WLC-LW nrPDB Length = 554 Score = 56.0 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 43/248 (17%), Positives = 81/248 (32%), Gaps = 36/248 (14%) Query: 35 SPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDW 94 +P + LG +NG + ++ + P L + P+ SIA G + T+ D Sbjct: 241 NPWNAVMHLGHSNGTVSLWSP----SMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADR 296 Query: 95 SIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLL 154 S+K+WD+ + +P D + + + A L Sbjct: 297 SMKIWDIRNFKQLHSVESLPTPGTNVSISDTG----LLALSRGPHVTLW-----KDALKL 347 Query: 155 SKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITS 214 S + S + + +T + + + G L F F L Sbjct: 348 SGDSKPCFGSMGGNPH-----RNTPYMSHLFAGNKVENLGFVPFEDLLG-------VGHQ 395 Query: 215 SNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILF 274 + I +LIV GE Y+ + + E + + ++NKL + I Sbjct: 396 TGITNLIVPGAGEA-----------NYDALELNPFETKKQRQEQEVRTLLNKLPADTITL 444 Query: 275 SNNTAEYL 282 N+ + Sbjct: 445 DPNSIGSV 452 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 54/161 (33%), Gaps = 17/161 (10%) Query: 6 QDPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPG 65 Q + + +H H ++ + L F P L G L +D+ T + + Sbjct: 170 QKKYTFIYDHEGTELHRLKQHIEARHLDFLPYHYLLVTAGETGWLKYHDVSTGQLV---- 225 Query: 66 NMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDA 125 + L P ++A +P ++ + ++ LW S P +K + P+ Sbjct: 226 SELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAI--- 282 Query: 126 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTP 166 + S Y+ D + + KQL S Sbjct: 283 ----------DRSGYYMATTGADRSMKIWDIRNFKQLHSVE 313 Score = 41.4 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 20/84 (23%), Positives = 37/84 (44%), Gaps = 6/84 (7%) Query: 16 PEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPI 75 PE L + + G Y+A A+ ++ I+D+ F+ + + + + P Sbjct: 264 PEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQL----HSVESLPTPG 319 Query: 76 TSIAWSPDGRLLLTSSRDWSIKLW 99 T+++ S G LL SR + LW Sbjct: 320 TNVSISDTG--LLALSRGPHVTLW 341 >3EI3-B nrPDB Length = 383 Score = 54.9 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 51/344 (14%), Positives = 103/344 (29%), Gaps = 23/344 (6%) Query: 5 LQDPF-AVLKEHP-EKLTHTIENPLRTECLQFSPCG-DYLALGCANGALVIYDMDTFRPI 61 LQ+PF LK + + + R L++ P +A+G G ++++D D Sbjct: 52 LQEPFIRSLKSYKLHRTASPFDR--RVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKT 109 Query: 62 CVPGNMLGAHVRPITSIAWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGC 120 M IT + ++ + L SS + L D S + W C Sbjct: 110 SFIQGM--GPGDAITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYC 167 Query: 121 QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH 180 + R +AT + LL D ++ H + Sbjct: 168 CVDVSVSRQMLAT------------GDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPR 215 Query: 181 PN-IIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ-NGERLAINCSDRTI 238 + ++ + + + ++ + + + + +L I Sbjct: 216 CDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEI 275 Query: 239 RQYEISIDDENSAVELTLEHKYQDVIN-KLQWNCILFSNNTAEYLVASTHGSSAHELYIW 297 R Y + + + ++Q + K W+ + Y + + I+ Sbjct: 276 RVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLLNDKRTIDIY 335 Query: 298 ETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWS 341 + SG LV L I F V N+ +W+ Sbjct: 336 DANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFNILIWN 379 >6CVZ-A nrPDB Length = 351 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 49/283 (17%), Positives = 96/283 (33%), Gaps = 18/283 (6%) Query: 71 HVRPITSIAWSPDGR-LLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRL 129 H + I +A+S R LLL++S D +IKL L + ++ P+W C W + Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLET-NTVVQTYNAGRPVWSCCWCLDEANY 131 Query: 130 CVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTS 189 A + V D N + + + + + ++ Sbjct: 132 IYAGLA-NGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAGTLE 190 Query: 190 KGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDR---TIRQ----YE 242 K + + I + + L D+ TIR Sbjct: 191 DASFWEQKMDFSHWPHVLPLEPG--GCIDFQTENSSRHCLVTYRPDKNHTTIRSVLMEMS 248 Query: 243 ISIDDENSAV-ELTLEHKYQDV--INKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET 299 +DD + + H + L N I S ++ T +A+ +W+ Sbjct: 249 YRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVCTGDEAANSALLWDA 308 Query: 300 TSGTLVRVLEGAEEELIDIN-WDFYSMSIVSNGFESGN-VYVW 340 SG+L++ L+ ++ ++DI ++ S ++ E +Y W Sbjct: 309 ASGSLLQDLQ-TDQPVLDICPFEVNRNSYLATLTEKMVHIYKW 350 >5BJS-A nrPDB Length = 605 Score = 52.6 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 31/174 (17%), Positives = 54/174 (31%), Gaps = 8/174 (4%) Query: 22 TIENPLRTECLQFSPCGDYL-ALGCANGALVIYDMDTFRPICVPGNMLGA--HVRPITSI 78 + + L SP Y+ A + + I+ + +LG H + S+ Sbjct: 174 LVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSV 233 Query: 79 AWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW--LDAKRRLCVATIFE 136 A+ +GR +L++ D I LW L P P + + I+ + + L F Sbjct: 234 AFHDNGRYVLSAGHDQVINLWAL--PEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFY 291 Query: 137 ESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSK 190 D + ++ L P T TK T Sbjct: 292 -GDLILSRACHEDTIVLWRIEGFSSDDPIPGPLDAPTPTDMTKQTRSYFTPTVS 344 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 22/166 (13%), Positives = 49/166 (29%), Gaps = 14/166 (8%) Query: 124 DAKRRLCVATIFEES---DAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKH 180 D C + ++ + N+ + + ++ K + HG + + Sbjct: 130 DGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPA 189 Query: 181 PNIIIVGTSKGWLDFYKFHSLYQTE------CIHSLKITSSNIKHLIVSQNGERLAINCS 234 II S + SL CI + S ++ + NG + Sbjct: 190 NPYIIASASD--DTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGH 247 Query: 235 DRTIRQYEISIDDENS---AVELTLEHKYQDVINKLQWNCILFSNN 277 D+ I + + + + H I+ +C+ F + Sbjct: 248 DQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGD 293 Score = 46.4 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 24/187 (12%), Positives = 56/187 (29%), Gaps = 27/187 (14%) Query: 114 DSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV 173 +P +C T + DA + + S P L+ Sbjct: 92 GAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPLL 151 Query: 174 CTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGER-LAIN 232 C G K +++ + + +L I L S +A Sbjct: 152 CIA--------------GNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASA 197 Query: 233 CSDRTIRQYEISID-DENSAVELTLEHKYQDVINKLQWNCILFSN-NTAEYLVASTHGSS 290 D TIR + ++ + ++ V + + ++ + + + Y++++ H Sbjct: 198 SDDTTIRIWSLAPEHEKQPCVCILGGEGH-------SYDLLSVAFHDNGRYVLSAGH--- 247 Query: 291 AHELYIW 297 + +W Sbjct: 248 DQVINLW 254 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 20/133 (15%), Positives = 45/133 (33%), Gaps = 10/133 (7%) Query: 216 NIKHLIVSQNGERLAINCSDR----TIRQYEISIDDENSAVELTLEHKYQDVINKLQWNC 271 ++K S G + + R + + D N + L + + NC Sbjct: 82 DVKFYPYSPPGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRD-----DGNEANC 136 Query: 272 I-LFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSN 330 +S + + + ++ T G L R L G + D+ + I+++ Sbjct: 137 ASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIAS 196 Query: 331 GFESGNVYVWSVV 343 + + +WS+ Sbjct: 197 ASDDTTIRIWSLA 209 >3DWL-C nrPDB Length = 377 Score = 52.6 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 28/227 (12%), Positives = 67/227 (29%), Gaps = 32/227 (14%) Query: 33 QFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSR 92 F+ A + +Y+ D H + +T + W+P ++T S+ Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNG--WKHARTFSDHDKIVTCVDWAPKSNRIVTCSQ 75 Query: 93 DWSIKLWDLSKPSKPLKE---IRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDP 149 D + +++ + +R + +W + + V + A VI Sbjct: 76 DRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGS-----GARVISVCYFE 130 Query: 150 VASLLSKSDE--KQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFH-------- 199 + S + L ST ++ + ++ G + + Sbjct: 131 QENDWWVSKHLKRPLRST------ILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKP 184 Query: 200 ------SLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQ 240 S + + + + + S +G LA D ++ Sbjct: 185 EASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTI 231 Score = 46.4 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 23/186 (12%), Positives = 57/186 (30%), Gaps = 12/186 (6%) Query: 157 SDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSN 216 + + L P Y + T+ ++ Y+ + + Sbjct: 2 ATSQVLHILPKPSYE---HAFNSQRTEFVTTTATNQVELYE-QDGNGWKHARTFSDHDKI 57 Query: 217 IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN 276 + + + R+ DR YE D + L + N F+ Sbjct: 58 VTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAV 117 Query: 277 NTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGN 336 + +++ + ++ ++ S L R L ++ ++W ++ +++ G Sbjct: 118 GSGARVISVCYFEQENDWWV----SKHLKRPL---RSTILSLDWHPNNV-LLAAGCADRK 169 Query: 337 VYVWSV 342 YV S Sbjct: 170 AYVLSA 175 Score = 45.6 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 40/334 (11%), Positives = 96/334 (28%), Gaps = 24/334 (7%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 ++ C+ ++P + + + +Y+ +L + T + WSP+ Sbjct: 53 DHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAA-TFVRWSPN 111 Query: 84 GRLLLTSSRDWSIKLWDLSKPSK--PLKEIR--FDSPIWGCQWLDAKRRLCVATIFEESD 139 S I + + + K ++ S I W L ++ Sbjct: 112 EDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAY 171 Query: 140 A---YVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV-CTVHTKHPNIIIVGTSKGWLDF 195 YV D P AS+ V + N + + Sbjct: 172 VLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTI 231 Query: 196 -YKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQ------YEISIDDE 248 Y + ++K++ ++ L+ + +A + I + + D + Sbjct: 232 AYPSAPEQPPRALITVKLSQLPLRSLLWANESAIVAAGYNYSPILLQGNESGWAHTRDLD 291 Query: 249 NSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVL 308 + + H + + + F+ + + GSS + T ++ L Sbjct: 292 AGTSKTSFTHTGNTGEGREEEGPVSFTALRSTFRNMDLKGSSQSISSL-PTVHQNMIATL 350 Query: 309 EGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 342 +I ++ G V +W++ Sbjct: 351 RPYAGTPGNIT-------AFTSSGTDGRVVLWTL 377 >3I2N-A nrPDB Length = 357 Score = 52.2 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 38/247 (15%), Positives = 82/247 (33%), Gaps = 23/247 (9%) Query: 12 LKEHPEKLTHTIENPLRTECLQF---SPCGDYLALGCANGALVIYDMDTFRPICVPGNML 68 ++ KL IE +C F S YLA G G L I++++ +P + Sbjct: 51 IQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPE---MPVYSV 107 Query: 69 GAHVRPITSIAWSPDGRL------LLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW 122 H I +I + ++T SRD ++K+WD + P+ + P+ G + Sbjct: 108 KGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANME---PVQG-EN 163 Query: 123 LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP- 181 + + + + V ++ L + L + + + Sbjct: 164 KRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMA-LRWETNIKNGVCSLEFDRKDI 222 Query: 182 --NIIIVGTSKGWLDFYKFHSLYQTE--CIHSLKITSSNIKHLIVSQNGERL-AINCSDR 236 N ++ + +G + + + T+ S K S + + L Sbjct: 223 SMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAG 282 Query: 237 TIRQYEI 243 + ++ Sbjct: 283 GLHLWKY 289 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 29/214 (13%), Positives = 61/214 (28%), Gaps = 25/214 (11%) Query: 110 EIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHG 169 + F+ ++ C+W+ + F + + L + EK Sbjct: 14 QKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTF 73 Query: 170 YVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIK------HLIVS 223 + G G L + ++S+K I L + Sbjct: 74 GATSL-----QQRYLATGDFGGNLHIWNLE--APEMPVYSVKGHKEIINAIDGIGGLGIG 126 Query: 224 QNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSN-NTAEYL 282 + + D T++ ++ D+ + Q + W + N E + Sbjct: 127 EGAPEIVTGSRDGTVKVWDPRQKDDP----VANMEPVQGENKRDCWTVAFGNAYNQEERV 182 Query: 283 VASTHGSSAHELY-------IWETTSGTLVRVLE 309 V + + + +L+ WET V LE Sbjct: 183 VCAGYDNGDIKLFDLRNMALRWETNIKNGVCSLE 216 Score = 34.1 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 14/36 (38%), Positives = 25/36 (69%), Gaps = 1/36 (2%) Query: 72 VRPITSIAWSPDGR-LLLTSSRDWSIKLWDLSKPSK 106 +PI+S+ WSPD R L + SS D ++++ ++K +K Sbjct: 321 TQPISSLDWSPDKRGLCVCSSFDQTVRVLIVTKLNK 356 Score = 30.6 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 27/80 (33%), Gaps = 11/80 (13%) Query: 270 NCILFSNNT--AEYLVASTHGSSAHELYIWETTSGTL-VRVLEGAEEELIDINWDFYSMS 326 C F + YL G + H IW + + V ++G +E + I+ Sbjct: 69 KCGTFGATSLQQRYLATGDFGGNLH---IWNLEAPEMPVYSVKGHKEIINAIDGIGGLGI 125 Query: 327 I-----VSNGFESGNVYVWS 341 + G G V VW Sbjct: 126 GEGAPEIVTGSRDGTVKVWD 145 >5MC6-j nrPDB Length = 397 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 47/324 (14%), Positives = 100/324 (30%), Gaps = 37/324 (11%) Query: 27 LRTECLQFSPCGDYLALGCANGALVIYD---MDTFRPICVPGNML----GAHVRPITSIA 79 + S C + +G L ++D +D P + G H + A Sbjct: 15 HDADIFSVSACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDVLQ-A 73 Query: 80 WSPDGR---LLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 D L+ T+S + + +++ + K I + Sbjct: 74 IERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWGASN 133 Query: 137 E-------------SDAYVIDF-----SNDPVASLLSKSDEKQLSST-PDHGYVLVCTVH 177 + Y+ F ++ + S + E Q + P +V Sbjct: 134 DRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVD 193 Query: 178 TKHPNIIIVGTSKGWLDFYKFHS---LYQTECIHSLKITSSNIKHLIVSQNGERLAINCS 234 +I G + G + + + LY E HS+ S++I+ + S G LAI Sbjct: 194 ISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHD 253 Query: 235 DRT---IRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSA 291 + I YE + ++ + H Q + + + + S + + Sbjct: 254 SNSFGCITLYETEFGERIGSLSVPT-HSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWD 312 Query: 292 HELYIWETTSGTLVRVLEGAEEEL 315 +L W+ + + L +++ Sbjct: 313 GKLRFWDVKTKERITTLNMHCDDI 336 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 65/166 (39%), Gaps = 12/166 (7%) Query: 18 KLTHTIENPL----RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICV--PGNMLGAH 71 +L T+E+P+ + S G +A G NG + I ++ T RP+ + + + Sbjct: 174 ELQGTVESPMTPSQFATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINN 232 Query: 72 VRPITSIAWSPDGRLLLTSSRDWS---IKLWDLSKPSKPLKEIRFDSPIWGCQWLD-AKR 127 I S+ +SP G LL + S I L++ ++ + + + + + A Sbjct: 233 SNSIRSVKFSPQGSLLAIAHDSNSFGCITLYE-TEFGERIGSLSVPTHSSQASLGEFAHS 291 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLV 173 ++ F +S + D ++++++ H + Sbjct: 292 SWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIE 337 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 22/113 (19%), Positives = 45/113 (39%), Gaps = 13/113 (11%) Query: 14 EHPEKLTHT-IENPLRTECLQFSPCGDYLALG---CANGALVIYDMDTFRPIC---VPGN 66 + + H+ I N ++FSP G LA+ + G + +Y+ + I VP + Sbjct: 220 LYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTH 279 Query: 67 MLGA------HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRF 113 A H + S++++ G L ++ D ++ WD+ + Sbjct: 280 SSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMH 332 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 58/339 (17%), Positives = 109/339 (32%), Gaps = 54/339 (15%) Query: 69 GAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD---LSKPSKPLKEIRFDSPIWGCQWLD- 124 AH I S+ S ++ S D +K+WD L + K G +D Sbjct: 13 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 125 ------AKRRLC-VATIFEESDAYVIDFSNDPVASLLSKSDEKQL-SSTPDHGY---VLV 173 LC VAT D + + + L S H + Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWG 130 Query: 174 CTVHTKHPNIIIVGTSKGWLDFYKFHS--------LYQTECIHSLKIT-------SSNIK 218 + + ++ KG +KFH L+ T S Sbjct: 131 ASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFAT 190 Query: 219 HLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNT 278 + +S+ G +A ++ T++ E+S E +H + N + + FS Sbjct: 191 SVDISERG-LIATGFNNGTVQISELSTLRPLYNFES--QHSMINNSNSI--RSVKFSPQ- 244 Query: 279 AEYLVASTHGSSAHELYIWETTSGTLVRVLE-------------GAEEELIDINWDFYSM 325 L + +S + ++ET G + L ++ ++++ Sbjct: 245 GSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGE 304 Query: 326 SIVSNGFESGNVYVWSVVIPPKWSALAP--DFEEVEENV 362 ++ S G+ G + W V + + L D E+EE++ Sbjct: 305 TLCSAGW-DGKLRFWDVKTKERITTLNMHCDDIEIEEDI 342 >5WLC-LH nrPDB Length = 896 Score = 48.7 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 22/161 (13%), Positives = 50/161 (31%), Gaps = 17/161 (10%) Query: 94 WSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL 153 ++ L ++S K L + D + + V ++F++S + Sbjct: 194 HNVILSNISSNGKLLAHMCKDVSTKD----HEHKSISVVSLFDDSVNLSFPLGSIL---- 245 Query: 154 LSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKIT 213 Q S + + + VG + G + L I LK Sbjct: 246 -----SSQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ----IRLLKWH 296 Query: 214 SSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVEL 254 ++ L S +G L ++ + +++ + + L Sbjct: 297 IDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRL 337 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 34/166 (20%), Positives = 64/166 (38%), Gaps = 12/166 (7%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 N + G LA+G A+G + I + + +L H+ + S+++S DG Sbjct: 255 NTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-----IRLLKWHIDSVLSLSFSHDG 309 Query: 85 RLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATI------FEES 138 LL+ + + LW L S+ R + I CQ L + + Sbjct: 310 SYLLSGGWEKVMSLWQLETNSQQF-LPRLNGIIIDCQVLGPQGNYYSLILQMTENNSNSD 368 Query: 139 DAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNII 184 +++ ++D + L +ST H + ++TK+ N I Sbjct: 369 YQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSI 414 Score = 34.1 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 29/197 (14%), Positives = 57/197 (28%), Gaps = 39/197 (19%) Query: 75 ITSIAWSPDGRLLLT-----------SSRD--WSIKLWDLSKPSKPLKEIR-----FDSP 116 IT + ++ DG+ ++T SS+D +K W + Sbjct: 495 ITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGIS 554 Query: 117 IWGCQWLDAKRRLCVA----TIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTP----DH 168 + + L + R + + T F S L +H Sbjct: 555 VPITKILPSPRSVNNSQGCLTADNNGGLKFWSF--------DSHESNWCLKKISLPNFNH 606 Query: 169 GYVLVCTVHTKHPNIIIVGTSKG-----WLDFYKFHSLYQTECIHSLKITSSNIKHLIVS 223 V ++ ++I G + F KF SL T+ + + S +++ Sbjct: 607 FSNSVSLAWSQDGSLIFHGFDDKLQILDFDTFKKFESLENTKTVSEFTLDSEIQTVKLIN 666 Query: 224 QNGERLAINCSDRTIRQ 240 +A + I Sbjct: 667 DTNLIVATRTTLNAINL 683 Score = 29.1 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 23/101 (22%), Positives = 37/101 (36%), Gaps = 11/101 (10%) Query: 43 LGCANGALVIYDMDTFRPICVPGNM---LGAHVRPITSIAWSPDGRLLLTSSRDW----- 94 NG L + D+ + H S+AWS DG L+ D Sbjct: 575 TADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHGFDDKLQILD 634 Query: 95 --SIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 + K ++ + +K + E DS I + ++ L VAT Sbjct: 635 FDTFKKFESLENTKTVSEFTLDSEIQTVKLINDT-NLIVAT 674 >5WLC-LS nrPDB Length = 594 Score = 48.3 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 46/354 (12%), Positives = 97/354 (27%), Gaps = 43/354 (12%) Query: 25 NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAW---- 80 + + L F P L G + L IY +D V L PI + + Sbjct: 247 SHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVG--SPIQTCTFYTSL 304 Query: 81 -SPDGRLLLTSSRDWSIKLWDLS----------KPSKPLKEIRFDSPIWGCQWLDAKRRL 129 + + + + T+ R + WDLS K K + +S + Sbjct: 305 SNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQ 364 Query: 130 CVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP-----NII 184 T + +N + L S S + + C + I+ Sbjct: 365 NSQTNSVHGIVLLQ-GNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTIL 423 Query: 185 IVGTSKGWL---------DFYKFHSLYQTECIHSLKITSSNIKH-----LIVSQNGERLA 230 I + G + + I +++ + + LA Sbjct: 424 IAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLA 483 Query: 231 INCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVAS-THGS 289 + + Y+ + D + N + FS + +AS Sbjct: 484 VGSESGFVNLYD---RNNAMTSSTPTPVAALDQLTTTISN-LQFSPDGQILCMASRAVKD 539 Query: 290 SAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 343 + +++ + + ++ + + + G E G V +W + Sbjct: 540 ALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAV-GNEQGKVRLWKLN 592 Score = 34.1 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 20/48 (41%), Gaps = 4/48 (8%) Query: 10 AVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDT 57 +V P T + + FSP G LA+G G + ++ ++ Sbjct: 550 SVFSNWPTSGTPL----GKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 >3DW8-B nrPDB Length = 447 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 47/350 (13%), Positives = 104/350 (29%), Gaps = 80/350 (22%) Query: 29 TECLQFSPCGDYLALGCANGALVIYDMD-------TFRPICVPGNMLGAHVRP------- 74 ++F+ G+ LA G G +VI+ + R + +H Sbjct: 31 ISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSL 90 Query: 75 -----ITSIAWSP--DGRLLLTSSRDWSIKLWDLSKPSKPL---------KEIRFDSPIW 118 I I W P + L S+ D +IKLW +S+ K R + + Sbjct: 91 EIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVT 150 Query: 119 GC-----------------QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQ 161 + + +I SD ++D +L + Sbjct: 151 TLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDR 210 Query: 162 LSST--------PDHGYVLVCTVHTKHP-NIIIVGTSKGWLDFYKFH------------- 199 + + V+ + N + +SKG + Sbjct: 211 SFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFE 270 Query: 200 --SLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLE 257 S I+S I + S +G + +++ +++++++ E Sbjct: 271 EPEDPSNRSFFSEIISS--ISDVKFSHSGRYMMTRDY-LSVKVWDLNMENRPVETYQVHE 327 Query: 258 HKYQDVINKLQWNCIL----FSNNTAEYLVASTHGSSAHELYIWETTSGT 303 + + + + +CI N ++ +V GS + +++ + Sbjct: 328 YLRSKLCSLYENDCIFDKFECCWNGSDSVV--MTGSYNNFFRMFDRNTKR 375 Score = 38.7 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 42/120 (35%), Gaps = 17/120 (14%) Query: 8 PFAVLKEHPEKLTHTIENPLRTECLQFSPCG-DYLALGCANGALVIYDMDTFRPICVPGN 66 F ++ P + E E F P + + G + + DM Sbjct: 211 SFNIVDIKPANMEELTEVITAAE---FHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSK 267 Query: 67 MLGAHVRP------------ITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFD 114 + P I+ + +S GR ++T S+K+WDL+ ++P++ + Sbjct: 268 LFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDY-LSVKVWDLNMENRPVETYQVH 326 >5WLC-LL nrPDB Length = 643 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 85/239 (35%), Gaps = 24/239 (10%) Query: 7 DPFAVLKEHPEKLTHTIENPLRTECLQF----SPCGDYLALGCANGALVIYDMDTFRPIC 62 V E + ++ L+ CL++ S + LG NG + +Y + Sbjct: 38 TSSGVDTVWNENFLYLEDSKLKVTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANE--- 94 Query: 63 VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW 122 V + I I + + SS + +DL + K L+ R ++ + Sbjct: 95 VTYKFTTGNSYEIKDIDLMGNQLWCIDSSDAFY--QFDLLQF-KLLQHFRINNCV----- 146 Query: 123 LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPN 182 +L TI D+ SL+ ++K + + P H + + Sbjct: 147 -----QLNKLTIVPAGDSVAQLLVASHSISLIDIEEKKVVMTFPGHVSPVSTLQVITNEF 201 Query: 183 IIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQY 241 I +L+ Y HS T+C+ + S+IK L S + +A+ D ++ + Sbjct: 202 FISGAEGDRFLNVYDIHSGM-TKCV---LVAESDIKELSHSGQADSIAVTTEDGSLEIF 256 >4AV8-A nrPDB Length = 339 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 21/143 (14%), Positives = 50/143 (34%), Gaps = 6/143 (4%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 ++ + GD +A +G +I T + V G I + WSPDG L S Sbjct: 185 VRLNRKGDMVATCSQDGT-LIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGSKLAVVS 243 Query: 92 RDWSIKLWDLSKPSKPLKEIR---FDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 148 W++ ++++ ++ + + + + +W +L V+ + + S+ Sbjct: 244 DKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSNDC--KIAWISDT 301 Query: 149 PVASLLSKSDEKQLSSTPDHGYV 171 + + + Sbjct: 302 GLVIVWPNRRLADTFKLNYNDDE 324 Score = 36.8 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 21/125 (16%), Positives = 46/125 (36%), Gaps = 6/125 (4%) Query: 48 GALVIYDMDTFRPICV-PGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSK 106 G + + + T V G ++ AH P+ + + G ++ T S+D ++ + Sbjct: 154 GQIHVTRLQTDAEQVVGKGVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGV 213 Query: 107 PLKEIRF---DSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLS 163 ++E R + I +W +L A + ++ +V + ND D + Sbjct: 214 LVREFRRGLDRTSIIDMRWSPDGSKL--AVVSDKWTLHVFEVFNDAENKRHVLKDWINIK 271 Query: 164 STPDH 168 Sbjct: 272 YFQSE 276 Score = 32.5 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 8/33 (24%), Positives = 19/33 (57%), Gaps = 1/33 (3%) Query: 211 KITSSNIKHLIVSQNGERLAINCSDRT-IRQYE 242 K ++ +K + +++ G+ +A D T IR ++ Sbjct: 176 KAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQ 208 >6IYY-A nrPDB Length = 317 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 39/257 (15%), Positives = 81/257 (31%), Gaps = 28/257 (10%) Query: 34 FSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRD 93 F+ A G +Y+ D + L V + + L L Sbjct: 15 FNQDHGCFACG-MENGFRVYNTDPLKE-KEKQEFLEGGVGHVEML--FRCNYLALVGGGK 70 Query: 94 WSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL 153 + +WD K K + EI F + + + + + + +S V F+ Sbjct: 71 KKVMIWDDLK-KKTVIEIEFSTEVKAVKLRRDRIVVVL-----DSMIKVFTFT------- 117 Query: 154 LSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKIT 213 + + + + V ++ + + GT G + S + + Sbjct: 118 HNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTE--KPPVDIPAH 175 Query: 214 SSNIKHLIVSQNGERLAINCSDRT-IRQYEISIDDENSAVELTLEHKYQDVINKLQWNCI 272 + + ++ G R+A T IR ++ S L + + CI Sbjct: 176 EGVLSCIALNLQGTRIATASEKGTLIRIFDTSSG--------HLIQELRRGSQAANIYCI 227 Query: 273 LFSNNTAEYLVASTHGS 289 F+ + + V+S HG+ Sbjct: 228 NFNQDASLICVSSDHGT 244 Score = 37.9 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 67/198 (33%), Gaps = 29/198 (14%) Query: 25 NPLRTECLQFSPCG----------DYLAL-GCANGALVIYDMDTFRPICVPGNMLGAHVR 73 + L ++P G LA G G + + D+ + P + AH Sbjct: 121 HQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEK---PPVDIPAHEG 177 Query: 74 PITSIAWSPDGRLLLTSSRDWS-IKLWDLSKPS--KPLKEIRFDSPIWGCQWLDAKRRLC 130 ++ IA + G + T+S + I+++D S + L+ + I+ + +C Sbjct: 178 VLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLIC 237 Query: 131 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSK 190 V++ + ++ + S PN +I + Sbjct: 238 VSS--DHGTVHIFAAE--------DPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICAD 287 Query: 191 GWLDFYKFHSLYQTECIH 208 G +YKF + ECI Sbjct: 288 GS--YYKFLFNPKGECIR 303 >5LTD-A nrPDB Length = 525 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 37/105 (35%), Gaps = 2/105 (1%) Query: 11 VLKEHPEKLTHTIENP-LRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLG 69 + + T IE + S G LA G + I I + G Sbjct: 206 IFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTI-IRVFSVATGIKLYQFRRG 264 Query: 70 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFD 114 + I S+A+SPD R ++ SS ++ ++ L + + Sbjct: 265 TYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSAN 309 >4NOX-A nrPDB Length = 746 Score = 37.9 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 31/90 (34%), Gaps = 15/90 (16%) Query: 13 KEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGA----LVIYDMDTFRPICVPGNML 68 + K T+E + +SP G ++ + + L +D+D L Sbjct: 509 QVGSFKHLRTLEKKNH-NAIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENEKDL 567 Query: 69 GA---------HVRPITSIAWSPDGRLLLT 89 A H IT + W P GR + T Sbjct: 568 AACLQLMGTGDHYG-ITDVEWDPSGRYVAT 596 Score = 29.8 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 44/130 (33%), Gaps = 11/130 (8%) Query: 208 HSLKITSSNIKHLIVSQNGERLAINCSDRT----IRQYEISIDDENSAVELTLEHKYQDV 263 H + N + S G + I T + +++ D E E L Q + Sbjct: 515 HLRTLEKKNHNAIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENEKDLAACLQLM 574 Query: 264 INKLQWNCILFSNNTAEYLVASTHGSSAHEL----YIWETTSGTLVRVLEGAEEELIDIN 319 + + + VA+ + H + ++++ G L+R E E+ Sbjct: 575 GTGDHYGITDVEWDPSGRYVATWASAWKHTMENGYHLYDFK-GELLR--EEHIEKFKQWQ 631 Query: 320 WDFYSMSIVS 329 W ++++ Sbjct: 632 WRPRPPTLLT 641 >5OLJ-A nrPDB Length = 723 Score = 37.9 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 39/249 (15%), Positives = 82/249 (32%), Gaps = 14/249 (5%) Query: 50 LVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWS-IKLWDLSKPSKPL 108 +YD D R + P L HV + +SPDGR++ + IK +D + Sbjct: 120 AAVYDYDVRRNLVKP---LSEHVGKVMIPTFSPDGRMVAFVRDNNIFIKKFDFDTEVQVT 176 Query: 109 KEIRFDSPIWGC-QWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPD 167 + + +S + G W+ + + +D + F +++ Sbjct: 177 TDGQINSVLNGATDWVYEEEFGVTNLMSWSADNAFLAFVRSDESAVPEYRMPMYEDKLYP 236 Query: 168 HGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGE 227 Y + K S L Y T+ + I + + N + Sbjct: 237 EDYTYK---YPKAGEK----NSTVSLHLYNVAD-RNTKSVSLPIDADGYIPRIAFTDNAD 288 Query: 228 RLAINCSDRTIRQYE-ISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVAST 286 LA+ +R ++ + ++ +L L+ + ++ + F+ V+ Sbjct: 289 ELAVMTLNRLQNDFKMYYVHPKSLVPKLILQDMNKRYVDSDWIQALKFTAGGGFAYVSEK 348 Query: 287 HGSSAHELY 295 G + LY Sbjct: 349 DGFAHIYLY 357 >5AMS-A nrPDB Length = 431 Score = 37.9 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 15/120 (12%), Positives = 36/120 (30%), Gaps = 2/120 (1%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 83 ++ + P + G + ++ + P L + + S +++ + Sbjct: 63 KHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF--AGTLTGYGESVISCSFTSE 120 Query: 84 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 143 G L+T+ + + K K + WL + F +D V Sbjct: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 Score = 36.8 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 21/183 (11%), Positives = 51/183 (27%), Gaps = 15/183 (8%) Query: 165 TPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ 224 H + H + ++ G + HS + +L ++ + Sbjct: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPP-KFAGTLTGYGESVISCSFTS 119 Query: 225 NGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDV---INKLQWNCILFSNNTAE- 280 G L + + + ++ + V + F Sbjct: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 Query: 281 --YLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVY 338 Y + GS + SG V + + E I+ + ++ +V+ +S + Sbjct: 180 WCYQINEQDGSLEQLM------SGF-VHQQDCSMGEFINTDKGENTLELVTCSLDS-TIV 231 Query: 339 VWS 341 W+ Sbjct: 232 AWN 234 Score = 36.8 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 23/191 (12%), Positives = 44/191 (23%), Gaps = 23/191 (12%) Query: 63 VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW 122 H + +I P+ L+ T D LW P Sbjct: 56 NSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-----------TSHSQPPKFAGT 104 Query: 123 LDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDE----KQLSSTPDHGYVLVCTVHT 178 L ++ F +++ + K S + ++ H Sbjct: 105 LTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 Query: 179 KHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKI--TSSNIKHLIV--SQNGER---LAI 231 G + G + Y+ + + + + GE L Sbjct: 165 TIARTFAFGATDGSVWCYQINE-QDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 Query: 232 NCSDRTIRQYE 242 D TI + Sbjct: 224 CSLDSTIVAWN 234 Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 27/222 (12%), Positives = 61/222 (27%), Gaps = 18/222 (8%) Query: 18 KLTHTIENPLRTECLQFSPC-GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHV---- 72 KL ++ L+ P A G +G++ Y ++ H Sbjct: 146 KLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCS 205 Query: 73 -RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLK-----EIRFDSPIWGCQWLD-- 124 + + L+T S D +I W+ + K ++P Sbjct: 206 MGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPET 265 Query: 125 -AKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNI 183 K V + + N+ A L + + + + + ++ Sbjct: 266 LTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSL 325 Query: 184 IIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQN 225 + +G G + Y H + ++ L+ + Sbjct: 326 MAIGLVCGEILLY---DTSAWRVRHKFVL-EDSVTKLMFDND 363 >2I3T-A nrPDB Length = 341 Score = 37.5 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 27/66 (40%), Gaps = 4/66 (6%) Query: 29 TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 88 ++FSP +L ++G + +++ T + I + IA S D L L Sbjct: 254 VNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNE---DSVVKIACS-DNILCL 309 Query: 89 TSSRDW 94 +S D Sbjct: 310 ATSDDT 315 Score = 36.4 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 23/108 (21%), Positives = 36/108 (33%), Gaps = 16/108 (14%) Query: 42 ALGCANGALVIYDMDTFRPICVPGN--MLGAHVR---------PITSIAWSPDGRLLLTS 90 A +G + + D H P+ SI +SP + L T+ Sbjct: 210 ACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTA 269 Query: 91 SRDWSIKLWDL--SKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFE 136 D I W+L K K + DS + + LC+AT + Sbjct: 270 GSDGIISCWNLQTRKKIKNFAKFNEDSVVKIAC---SDNILCLATSDD 314 Score = 31.7 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 35/257 (13%), Positives = 73/257 (28%), Gaps = 33/257 (12%) Query: 12 LKEHPEKLTHTIENPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGA 70 ++ L ++ C F D + +G G ++ D+ P A Sbjct: 42 IQAKNVDLLQSLRYKHPLLCCNFIDNTDLQIYVGTVQGEILKVDL-IGSPSFQALTNNEA 100 Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWD-------------LSKPSKPLKEIRFDSP- 116 ++ I I D +L+ +S D I++ D L+ + +K F Sbjct: 101 NLG-ICRICKYGDDKLIA-ASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDT 158 Query: 117 -----IWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYV 171 I G + + L +++ + + G V Sbjct: 159 NSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRV 218 Query: 172 LVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAI 231 V + + +SK + +L T + + + S + L Sbjct: 219 AVEFFDDQGDDY---NSSKRFAFRCHRLNLKDTNLAY-------PVNSIEFSPRHKFLYT 268 Query: 232 NCSDRTIRQYEISIDDE 248 SD I + + + Sbjct: 269 AGSDGIISCWNLQTRKK 285 >3AZQ-A nrPDB Length = 662 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 26/210 (12%), Positives = 50/210 (23%), Gaps = 27/210 (12%) Query: 24 ENPLRTECLQFSPCGDYLALGCANGALVIYD--------MDTFRPICVPGNMLGAHVRPI 75 + + SP G + + ++ + +LG I Sbjct: 185 DAHRFVTGPRLSPDGRQAVWLAWDHPRMPWEGTELKTARVTEDGRFADTRTLLGGPEEAI 244 Query: 76 TSIAWSPDGRLLLTSSRDWSIKLWDL--------SKPSKPLKEIRFDSPIWGCQWLDAKR 127 W+PDG L++ + D + W+L + +E F P+W R Sbjct: 245 AQAEWAPDGSLIV--ATDRTGW-WNLHRVDPATGAATQLCRREEEFAGPLWT----PGMR 297 Query: 128 RLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVG 187 V+ V +L + L T+ + V Sbjct: 298 WFAPLA---NGLIAVVHGKGAAVLGILDPESGE-LVDAAGPWTEWAATLTVSGTRAVGVA 353 Query: 188 TSKGWLDFYKFHSLYQTECIHSLKITSSNI 217 S + + Sbjct: 354 ASPRTAYEVVELDTVTGRARTIGARHTDPV 383 >5WLC-LV nrPDB Length = 707 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 26/173 (15%), Positives = 53/173 (30%), Gaps = 15/173 (8%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRP--ITSIAWSPDGRLLLT 89 + + LA G + +D + + RP +T+ ++ DG Sbjct: 186 VSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLTFAC 245 Query: 90 SSRDWSIKLWDLS-KPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 148 + + ++DL +K+ + I WLD + E+ D Sbjct: 246 GTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDN--------VGTENKIVTCD---K 294 Query: 149 PVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSL 201 +A + + D K +S + + H + + Y SL Sbjct: 295 RIAKIWDRLDGKAYASM-EPSVDINDIEHVPGTGMFFTANESIPMHTYYIPSL 346 >5K1H-B nrPDB Length = 576 Score = 37.1 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 56/316 (17%), Positives = 101/316 (31%), Gaps = 38/316 (12%) Query: 32 LQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSS 91 +++SP G YLA G + ++ + F+ I +H + I +SP R L+T S Sbjct: 171 VRWSPKGTYLATFHQRG-IALWGGEKFKQIQRF-----SHQG-VQLIDFSPCERYLVTFS 223 Query: 92 --RDWS-----IKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVID 144 D I +WD+ + R W + F + Sbjct: 224 PLMDTQDDPQAIIIWDILTG----HKKRGFHCESSAHW-PIFKWSHDGKFFARMTLDTLS 278 Query: 145 FSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIII--VGTSKGWLDFYKFHSLY 202 P LL K K + + NII V K L Sbjct: 279 IYETPSMGLLDKKSLKISG--------IKDFSWSPGGNIIAFWVPEDKDIPARVTLMQLP 330 Query: 203 QTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQD 262 + I + + L +NG+ L + DRT + + + N + E + Sbjct: 331 SRQEIRVRNLFNVVDCKLHWQKNGDYLCV-KVDRTPKGTQGVV--TNFEIFRMREKQVPV 387 Query: 263 VINKLQWNCILFSNNTAEYLVASTHGSSAH----ELYIWETTSGTLVRVLEGAEEELIDI 318 + +++ I F+ A HG + ++ L ++ + +++ I Sbjct: 388 DVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFD--KQQANTI 445 Query: 319 NWDFYSMSIVSNGFES 334 W +V G S Sbjct: 446 FWSPQGQFVVLAGLRS 461 Score = 28.3 bits (61), Expect = 6.8, Method: Composition-based stats. Identities = 18/81 (22%), Positives = 32/81 (39%), Gaps = 15/81 (18%) Query: 28 RTECLQFSPCGDYLALG---CANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDG 84 + + +SP G ++ L NGAL D + + + + + + W P G Sbjct: 441 QANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMAS------DVEWDPTG 494 Query: 85 RLLLTSSR------DWSIKLW 99 R ++TS D + LW Sbjct: 495 RYVVTSVSWWSHKVDNAYWLW 515 >4R40-A nrPDB Length = 411 Score = 36.4 bits (82), Expect = 0.025, Method: Composition-based stats. Identities = 38/250 (15%), Positives = 78/250 (31%), Gaps = 21/250 (8%) Query: 74 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVAT 133 P+ S AWSPDG + + + S S + + + I + Sbjct: 182 PLMSPAWSPDGSKIAYVTFE--------SGKSALVIQTLANGAIRQVASFPRHNGAPAFS 233 Query: 134 IFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWL 193 A+ + S ++ + + T + N+ G Sbjct: 234 PDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNNTEPSWFPDSQNLAYTSDQGGRP 293 Query: 194 DFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVE 253 YK + + + + + ++ VS +G+ L + S+ Q+ D E AV+ Sbjct: 294 QVYKVNINGGVPQRITWEGSQN--QNADVSPDGKFLVLVSSNGGA-QHIAKQDLETGAVQ 350 Query: 254 LTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEE 313 + + L + N + +ST G + + +T G L + Sbjct: 351 VL--------TDTLLDETPSIAPNGTMVIYSSTQGLGSVLQLV--STDGRFKARLPATDG 400 Query: 314 ELIDINWDFY 323 ++ W Y Sbjct: 401 QVKFPAWSPY 410 >1J83-A nrPDB Length = 180 Score = 33.3 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 21/155 (13%), Positives = 53/155 (34%), Gaps = 5/155 (3%) Query: 89 TSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSND 148 T+ +D+S WD + + + DSPI +A L ++ + + + + + Sbjct: 3 TAPKDFSSGFWDFNDGTTQGFGVNPDSPITAINVENANNALKISNLNSKGSNDLSEGNFW 62 Query: 149 PVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV---GTSKGWLDFYKFHSLYQTE 205 + + + ++ D + T I ++ GW + + ++ Sbjct: 63 ANVRISADIWGQSINIYGDTKLTMDVIAPTPVNVSIAAIPQSSTHGWGNPTRAIRVWTNN 122 Query: 206 CIHSLKITSSNIKHLIV--SQNGERLAINCSDRTI 238 + T + S N +A + +D + Sbjct: 123 FVAQTDGTYKATLTISTNDSPNFNTIATDAADSVV 157 >6IGR-A nrPDB Length = 656 Score = 33.3 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 29/221 (13%), Positives = 64/221 (28%), Gaps = 40/221 (18%) Query: 33 QFSPCGDYLALGCANGALV--IYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 90 ++SP G LA + G + + + ++ WSPDGR + + Sbjct: 85 RWSPDGQNLAFVRSAGEVKAALMLLPLKGGEARRVTHFK---NGVSGPQWSPDGRFIAFT 141 Query: 91 --------------------------SRDW------SIKLWDLSKPSKPLKEIRFDSPIW 118 DW ++ L+D+ + K + + I Sbjct: 142 TTADTEDKRDERGEARVLTRPVYRANGADWLPERPAALWLYDV-EADKLREWYAPEIGIG 200 Query: 119 GCQWLDAKRRLCVATIFEESDAYVI--DFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTV 176 W R + + +E A D + P+ + + + ++L + L Sbjct: 201 ALSWWPDSRGVLIVQSEDEWQASQWRQDVYDLPLPTADAPAAPQKLLDWNSAAHGLAPHP 260 Query: 177 HTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNI 217 + +I KG + + + + + Sbjct: 261 DGQRFALIGRPAGKGNTEHAHLYLIENGQHRRLDTGHDHPV 301 >1C5K-A nrPDB Length = 439 Score = 33.3 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 30/253 (11%), Positives = 69/253 (27%), Gaps = 25/253 (9%) Query: 73 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVA 132 +P+ S AWSPDG L + + S S + + + + Sbjct: 201 QPLMSPAWSPDGSKLAYVTFE--------SGRSALVIQTLANGAVRQVASFPRHNGAPAF 252 Query: 133 TIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGW 192 + A+ + + ++ + + T T N+ G Sbjct: 253 SPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDQAGR 312 Query: 193 LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAV 252 YK + + + + + + VS +G+ + + + Sbjct: 313 PQVYKVNINGGAPQRITWEGSQN--QDADVSSDGKFM-------------VMVSSNGGQQ 357 Query: 253 ELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWET--TSGTLVRVLEG 310 + + + L + + + A + SS + T G L Sbjct: 358 HIAKQDLATGGVQVLSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPA 417 Query: 311 AEEELIDINWDFY 323 + ++ W Y Sbjct: 418 TDGQVKFPAWSPY 430 >1Z68-A nrPDB Length = 719 Score = 32.5 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 35/97 (36%), Gaps = 11/97 (11%) Query: 45 CANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIK------- 97 A+ +V+Y+++T + + N V ++ SPD + + S + Sbjct: 33 SADNNIVLYNIETGQSYTILSNRTMKSVNA-SNYGLSPDRQFVYLESDYSKLWRYSYTAT 91 Query: 98 --LWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVA 132 ++DL + ++ PI W +L Sbjct: 92 YYIYDL-SNGEFVRGNELPRPIQYLCWSPVGSKLAYV 127 >4YHC-A nrPDB Length = 468 Score = 32.1 bits (71), Expect = 0.41, Method: Composition-based stats. Identities = 19/130 (14%), Positives = 41/130 (31%), Gaps = 6/130 (4%) Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP--IWGCQWLDAKRR 128 H I IA S + + + D S+ +WDL + L + P + Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 129 LCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGT 188 + ++F + ++++ + + S K S ++V Sbjct: 89 V---SLFSKDTLFILNVESPSLMLQHSY-HSKPNSKLNVFWMPGTHKDDEWKNFELVVVE 144 Query: 189 SKGWLDFYKF 198 S G + + Sbjct: 145 SSGEIQVFSL 154 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 40/108 (37%), Gaps = 5/108 (4%) Query: 23 IENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSP 82 + + L + S A + +LV++D+ + V R + +IA P Sbjct: 27 VHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSK--EQMPRTLKAIALDP 84 Query: 83 DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIW--GCQWLDAKRR 128 G + S+D ++ + ++ PS L+ P W+ + Sbjct: 85 QGNYVSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGTHK 131 >2EEP-A nrPDB Length = 706 Score = 31.7 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 21/189 (11%), Positives = 53/189 (28%), Gaps = 15/189 (7%) Query: 49 ALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDW-----SIKLWDLSK 103 + IY + T + + + +T+++WSPD +L + + + +D Sbjct: 236 TVGIYHLATGKTV--YLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAET 293 Query: 104 PSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQL- 162 + +R +++ L ++ D L +L Sbjct: 294 G----RFVRTLFVETDKHYVEPLHPLTFLPGSNNQ--FIWQSRRDGWNHLYLYDTTGRLI 347 Query: 163 -SSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLI 221 T V + +++ F+ + S + Sbjct: 348 RQVTKGEWEVTNFAGFDPKGTRLYFESTEASPLERHFYCIDIKGGKTKDLTPESGMHRTQ 407 Query: 222 VSQNGERLA 230 +S +G + Sbjct: 408 LSPDGSAII 416 Score = 31.4 bits (69), Expect = 0.82, Method: Composition-based stats. Identities = 17/138 (12%), Positives = 46/138 (33%), Gaps = 2/138 (1%) Query: 198 FHSLYQTECIHSLKITSSN--IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELT 255 + L + ++ + +L S + L + +R + +++ D + + Sbjct: 239 IYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGRFVR 298 Query: 256 LEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEEL 315 D + + F + + + + LY+++TT + +V +G E Sbjct: 299 TLFVETDKHYVEPLHPLTFLPGSNNQFIWQSRRDGWNHLYLYDTTGRLIRQVTKGEWEVT 358 Query: 316 IDINWDFYSMSIVSNGFE 333 +D + E Sbjct: 359 NFAGFDPKGTRLYFESTE 376 >4BFG-A nrPDB Length = 216 Score = 31.0 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 30/70 (42%), Gaps = 3/70 (4%) Query: 22 TIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR-PITSIAW 80 T+++ C +P G++ + +++ T+ P + A P I+W Sbjct: 95 TLQHEGTYTCETVTPEGNF--EKNYDLQVLVPPEVTYFPEKNRSAVCEAMAGKPAAQISW 152 Query: 81 SPDGRLLLTS 90 SPDG + TS Sbjct: 153 SPDGDCVTTS 162 >6FYY-p nrPDB Length = 763 Score = 30.6 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 29/94 (30%), Gaps = 7/94 (7%) Query: 28 RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 87 T ++FSP G YL G P H + + + SP+ + L Sbjct: 232 STNYVRFSPKGTYLFSYHQQGVTAW-----GGPNFDRLRRFY-HPD-VRNSSVSPNEKYL 284 Query: 88 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 +T S + I D K IW Sbjct: 285 VTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIA 318 >5GRS-A nrPDB Length = 396 Score = 30.2 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 13/88 (14%), Positives = 31/88 (35%), Gaps = 5/88 (5%) Query: 71 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP--IWGCQWLDAKRR 128 H I IA S + + + D + +WDL + L + P + Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 129 LCVATIFEESDAYVIDFSNDPVASLLSK 156 + ++F + ++++ + + S Sbjct: 89 V---SLFSKDTLFILNVESPSLMLQHSY 113 >4U1F-A nrPDB Length = 497 Score = 30.2 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 29/94 (30%), Gaps = 7/94 (7%) Query: 28 RTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 87 T ++FSP G YL G P H + + + SP+ + L Sbjct: 64 STNYVRFSPKGTYLFSYHQQGVTAW-----GGPNFDRLRRFY-HPD-VRNSSVSPNEKYL 116 Query: 88 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQ 121 +T S + I D K IW Sbjct: 117 VTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIA 150 >6IOZ-A nrPDB Length = 517 Score = 30.2 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 13/33 (39%), Positives = 19/33 (57%), Gaps = 2/33 (6%) Query: 391 IDLRTREQYDVRGNNLLVERFTIPTDYTRIIKM 423 +D+R RE DV+ N+ V IP D+ R I+ Sbjct: 235 MDIRQRE--DVQALNISVPYGPIPVDFQRKIRQ 265 >4QUV-A nrPDB Length = 427 Score = 29.8 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 13/33 (39%) Query: 318 INWDFYSMSIVSNGFESGNVYVWSVVIPPKWSA 350 I +Y +V + WS V PP W A Sbjct: 41 ICVTYYQGELVFTSDAAAWRRFWSHVAPPTWHA 73 >1FLG-A nrPDB Length = 582 Score = 29.8 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 21/137 (15%), Positives = 44/137 (32%), Gaps = 7/137 (5%) Query: 97 KLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL--L 154 K W+ S+ + W + + + + + +D V SL + Sbjct: 412 KNWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTKGSAYLGMGFRIKRMYDDHVGSLRAM 471 Query: 155 SKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITS 214 K + +H L V N++ GT G+ +K + + + S Sbjct: 472 DPVSGKVVWEHKEH-LPLWAGVLATAGNLVFTGTGDGY---FKAFDAKSGKELWKFQTGS 527 Query: 215 SNIK-HLIVSQNGERLA 230 + + Q+GE+ Sbjct: 528 GIVSPPITWEQDGEQYL 544 >1KEU-A nrPDB Length = 361 Score = 29.4 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 21/41 (51%), Gaps = 1/41 (2%) Query: 15 HPEKLTHTIENPLRTECLQFSPCGDYLAL-GCANGALVIYD 54 HP+++ +++ PL TE ++P Y A ++ + + Sbjct: 142 HPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVRAWR 182 >2VDU-B nrPDB Length = 450 Score = 29.4 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 20/80 (25%), Positives = 32/80 (40%), Gaps = 7/80 (8%) Query: 39 DYLALGCANGALVIYDMDTFRPICVPGNM-LGAHVRPITSIAWSPDGRLLLTSSRDWSIK 97 ++ + + I + P C + L H ++SI D LLL++ D I Sbjct: 211 QFIITSDRDEHIKI----SHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIF 265 Query: 98 LWDLSKPSKPLKEIRFDSPI 117 WD K K L ++S I Sbjct: 266 AWDW-KTGKNLSTFDYNSLI 284 >5VAQ-A nrPDB Length = 954 Score = 29.4 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 19/44 (43%), Gaps = 5/44 (11%) Query: 272 ILFSNNTAEYL-----VASTHGSSAHELYIWETTSGTLVRVLEG 310 FS E + VAS+ S LY+W T L+ +EG Sbjct: 494 CDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEG 537 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.118 0.300 Lambda K H 0.267 0.0360 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,332,607 Number of Sequences: 36641 Number of extensions: 533272 Number of successful extensions: 4524 Number of sequences better than 10.0: 170 Number of HSP's better than 10.0 without gapping: 220 Number of HSP's successfully gapped in prelim test: 84 Number of HSP's that attempted gapping in prelim test: 1890 Number of HSP's gapped (non-prelim): 1122 length of query: 426 length of database: 10,336,785 effective HSP length: 100 effective length of query: 326 effective length of database: 6,672,685 effective search space: 2175295310 effective search space used: 2175295310 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 60 (27.9 bits)