BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P39108 (375 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3W15-A nrPDB 756 0.0 4XYI-A nrPDB 75 5e-14 5WJC-A nrPDB 65 4e-11 3C9C-A nrPDB 57 1e-08 5Y1U-A nrPDB 57 1e-08 3CFV-B nrPDB 57 1e-08 5M25-A nrPDB 46 2e-05 6Q8F-A nrPDB 46 3e-05 2H9P-A nrPDB 45 4e-05 6QX9-4B nrPDB 44 1e-04 5MZH-A nrPDB 42 4e-04 6QX9-5O nrPDB 42 4e-04 5OQL-d nrPDB 42 6e-04 6EMK-B nrPDB 41 8e-04 5FL8-q nrPDB 41 0.001 4A11-B nrPDB 41 0.001 5NNZ-B nrPDB 39 0.004 2HES-X nrPDB 38 0.007 5I2T-A nrPDB 38 0.008 4YCZ-A nrPDB 38 0.008 4LG8-A nrPDB 38 0.009 5FA5-B nrPDB 38 0.009 5A9Q-0 nrPDB 38 0.009 5WLC-LO nrPDB 38 0.009 6G51-g nrPDB 37 0.012 6EOJ-D nrPDB 37 0.015 4V7E-Bg nrPDB 37 0.016 4PSX-B nrPDB 37 0.016 5Z56-q nrPDB 36 0.023 3BG0-A nrPDB 36 0.023 5WLC-LU nrPDB 36 0.025 2AQ5-A nrPDB 36 0.034 4OWR-A nrPDB 35 0.036 6N9G-C nrPDB 35 0.042 3JRO-A nrPDB 35 0.051 3FM0-A nrPDB 35 0.055 3DM0-A nrPDB 35 0.059 1VYH-C nrPDB 34 0.11 3JZG-A nrPDB 34 0.11 3JRP-A nrPDB 33 0.20 4BTS-AR nrPDB 33 0.21 5A9Q-7 nrPDB 33 0.24 4BZK-B nrPDB 33 0.25 4G56-B nrPDB 33 0.26 3F3P-A nrPDB 33 0.28 5GAN-H nrPDB 33 0.30 5CXC-A nrPDB 32 0.31 5FVM-C nrPDB 32 0.38 5WYJ-BC nrPDB 32 0.39 5OQL-L nrPDB 32 0.47 5YZG-W nrPDB 32 0.48 4AEZ-A nrPDB 32 0.54 6F3T-A nrPDB 32 0.55 6QDV-o nrPDB 32 0.58 6MZM-G nrPDB 32 0.64 3JB9-L nrPDB 31 0.67 6F1U-h nrPDB 31 0.67 5XYI-g nrPDB 31 0.90 5L9T-R nrPDB 31 0.97 6HQA-B nrPDB 31 1.0 2PM9-A nrPDB 30 1.1 3JB9-g nrPDB 30 1.3 5OPT-p nrPDB 30 1.3 4J0W-A nrPDB 30 1.5 1PI6-A nrPDB 30 1.8 6J6H-n nrPDB 30 1.8 6BX3-A nrPDB 30 1.9 6CHG-A nrPDB 30 2.2 6ID0-T nrPDB 30 2.3 4V8M-A7 nrPDB 30 2.5 4OM9-A nrPDB 29 2.7 5OVO-B nrPDB 29 2.8 4CO4-A nrPDB 29 2.8 6HHQ-h nrPDB 29 3.2 5WLC-LW nrPDB 29 3.2 5WLC-LJ nrPDB 29 3.2 5BJS-A nrPDB 29 3.5 1C7Z-A nrPDB 28 4.7 6ELZ-p nrPDB 28 5.4 4U1E-I nrPDB 28 5.7 3I2N-A nrPDB 28 6.7 3NCV-A nrPDB 28 7.0 >3W15-A nrPDB Length = 368 Score = 756 bits (1953), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/375 (97%), Positives = 366/375 (97%), Gaps = 9/375 (2%) Query: 1 MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQ 60 MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQ Sbjct: 3 MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQ 62 Query: 61 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 120 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNF Sbjct: 63 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 122 Query: 121 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA 180 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA Sbjct: 123 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA 182 Query: 181 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG 240 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG Sbjct: 183 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG 242 Query: 241 VDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM 300 VDNAIRIWDIRMLNKN PGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM Sbjct: 243 VDNAIRIWDIRMLNKN---------PGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM 293 Query: 301 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA 360 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA Sbjct: 294 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA 353 Query: 361 STAWDGNLFVWNGLG 375 STAWDGNLFVWNGLG Sbjct: 354 STAWDGNLFVWNGLG 368 >4XYI-A nrPDB Length = 430 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 119/298 (39%), Gaps = 46/298 (15%) Query: 82 DGTLRLFDTT-FKEFPI------AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSP 134 +G +FD ++E PI A + H E F WN + + + D SI +W Sbjct: 153 NGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWD- 211 Query: 135 LRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCS 194 + + L + K +D + + + V QF + L+ S S Sbjct: 212 --------IKGKSLSLEKSIDVAPVSVYHRHTA--------VVNDLQFHLQHEALLTSVS 255 Query: 195 GNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 + + D RLPS + + + FN + Y++AT D+ + +WD+R LN Sbjct: 256 DDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLN 315 Query: 255 KNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDL 314 + +LH H + V WSPH IL+++S D +W DL Sbjct: 316 Q------------RLHTLE-------GHEDEVYNVQWSPHDEPILVTSSTDRRVCVW-DL 355 Query: 315 SNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 S G ++T + +S D +F H+ V W+ K +AS A D L +W+ Sbjct: 356 SKIGEEQTVE-DSEDGAPELMFMHGGHTNRVSDLSWNPNNK-WVLASLADDNILQIWS 411 Score = 35.0 bits (79), Expect = 0.054, Method: Compositional matrix adjust. Identities = 48/241 (19%), Positives = 89/241 (36%), Gaps = 65/241 (26%) Query: 177 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK-----NQNNFLVHSGLEALTCDFNKY 231 V +A+F P + +++ + N +FD+ L + L H E +N Sbjct: 134 VNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLGWNFI 193 Query: 232 RPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPG------------------------ 267 + +ATG D +I +WDI K +S ++++++ Sbjct: 194 QEGTLATGTEDTSICVWDI----KGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 268 -----------QLHN-----SSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 Q+H+ SS ++ AH + V ++P + +L +AS D T +W Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 312 RDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 DL + + H + V+ WS +P V S+ D + VW Sbjct: 310 -DLRRLNQR--------------LHTLEGHEDEVYNVQWSPHDEPILVTSST-DRRVCVW 353 Query: 372 N 372 + Sbjct: 354 D 354 Score = 28.1 bits (61), Expect = 6.5, Method: Compositional matrix adjust. Identities = 16/67 (23%), Positives = 33/67 (49%) Query: 66 LAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSW 125 +A+N ++ + A D T+ L+D + + HE EV++ W+ + ++SS Sbjct: 287 VAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSST 346 Query: 126 DGSIKIW 132 D + +W Sbjct: 347 DRRVCVW 353 >5WJC-A nrPDB Length = 430 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 80/331 (24%), Positives = 131/331 (39%), Gaps = 51/331 (15%) Query: 52 VEVNSFLTQDCLFDLAWNESHENQVLVAQGDG-TLRLFDTTFKE-------FPIAIFKEH 103 +E++ + D + A + +++ G+G +FDTT + P A+ K H Sbjct: 122 IEISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGH 181 Query: 104 EREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILK 163 E F WN N + + D I +W ++ QS + TK++ P I K Sbjct: 182 TAEGFGLCWNPNLPGNLATGAEDQVICLWD-VQTQSFTSSE------TKVISP----IAK 230 Query: 164 KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRL-PSGKNQNNFLVHS-GL 221 T I V QF P + L+ S S + + D RL P + HS + Sbjct: 231 YHRHTDI------VNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAI 284 Query: 222 EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNA 281 A+ N + Y++AT D + +WD+R + +LH Sbjct: 285 NAVA--INPFNDYLLATASADKTVALWDLRNPYQ------------RLHTLE-------G 323 Query: 282 HGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQH 341 H + + WSPH IL S+S D IW DL G ++T + ++ D + +F H Sbjct: 324 HEDEVYGLEWSPHDEPILASSSTDRRVCIW-DLEKIGEEQTPE-DAEDGSPELLFMHGGH 381 Query: 342 SEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + + W + V S A D L +W+ Sbjct: 382 TNRISEFSWCP-NERWVVGSLADDNILQIWS 411 >3C9C-A nrPDB Length = 432 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 62/276 (22%), Positives = 113/276 (40%), Gaps = 42/276 (15%) Query: 96 PIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVD 155 P + H++E + +WN LS+S D +I +W + TP+ Sbjct: 175 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD-------INATPKE-------- 219 Query: 156 PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 215 + +I K FTG + V + ++L S + + ++D R + ++ Sbjct: 220 --HRVIDAKNIFTG---HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHT 274 Query: 216 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 + E FN Y +++ATG D + +WD+R L +LH+ Sbjct: 275 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL------------KLHSFE-- 320 Query: 276 NEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSI 335 +H I +V WSPH+ IL S+ D +W DLS G +++ + ++ D + Sbjct: 321 -----SHKDEIFQVQWSPHNETILASSGTDRRLHVW-DLSKIGEEQSTE-DAEDGPPELL 373 Query: 336 FNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 F H+ + W+ +P + S + D + VW Sbjct: 374 FIHGGHTAKISDFSWNP-NEPWIICSVSEDNIMQVW 408 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 59/259 (22%), Positives = 107/259 (41%), Gaps = 38/259 (14%) Query: 64 FDLAWNESHENQVLVAQGDGTLRLFD--TTFKEFPIA----IFKEHEREVFSCNWNLVNR 117 + L+WN + +L A D T+ L+D T KE + IF H V W+L++ Sbjct: 187 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 246 Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 177 F S + D + IW T +P + VD A + NC+ Sbjct: 247 SLFGSVADDQKLMIWDTRNNN-----TSKP---SHTVDAHTAEV-------------NCL 285 Query: 178 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 237 F+P+ + ++ + S + +L+D+R K ++F H E ++ + ++A Sbjct: 286 ---SFNPYSEFILATGSADKTVALWDLRNLKLK-LHSFESHKD-EIFQVQWSPHNETILA 340 Query: 238 TGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSN 297 + G D + +WD+ + + +S P +L I H I +W+P+ Sbjct: 341 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLF------IHGGHTAKISDFSWNPNEPW 394 Query: 298 ILMSASYDMTCRIWRDLSN 316 I+ S S D ++W+ N Sbjct: 395 IICSVSEDNIMQVWQMAEN 413 >5Y1U-A nrPDB Length = 456 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 64/276 (23%), Positives = 113/276 (40%), Gaps = 42/276 (15%) Query: 96 PIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVD 155 P + H++E + +WN + LS+S D +I +W ++ P+ K+VD Sbjct: 200 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWD-------ISAVPKE---GKVVD 249 Query: 156 PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 215 K FTG + V + ++L S + + ++D R + ++ Sbjct: 250 -------AKTIFTG---HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHS 299 Query: 216 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 + E FN Y +++ATG D + +WD+R L +LH+ Sbjct: 300 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL------------KLHSF--- 344 Query: 276 NEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSI 335 +H I +V WSPH+ IL S+ D +W DLS G +E ++ D + Sbjct: 345 ----ESHKDEIFQVQWSPHNETILASSGTDRRLNVW-DLSKIG-EEQSPEDAEDGPPELL 398 Query: 336 FNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 F H+ + W+ +P + S + D + VW Sbjct: 399 FIHGGHTAKISDFSWNP-NEPWVICSVSEDNIMQVW 433 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 57/259 (22%), Positives = 108/259 (41%), Gaps = 38/259 (14%) Query: 64 FDLAWNESHENQVLVAQGDGTLRLFDTTF--KEFPIA----IFKEHEREVFSCNWNLVNR 117 + L+WN + +L A D T+ L+D + KE + IF H V +W+L++ Sbjct: 212 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 271 Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 177 F S + D + IW T +P + VD A + NC+ Sbjct: 272 SLFGSVADDQKLMIWDTRSNN-----TSKP---SHSVDAHTAEV-------------NCL 310 Query: 178 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 237 F+P+ + ++ + S + +L+D+R K ++F H E ++ + ++A Sbjct: 311 ---SFNPYSEFILATGSADKTVALWDLRNLKLK-LHSFESHKD-EIFQVQWSPHNETILA 365 Query: 238 TGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSN 297 + G D + +WD+ + + +S P +L I H I +W+P+ Sbjct: 366 SSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF------IHGGHTAKISDFSWNPNEPW 419 Query: 298 ILMSASYDMTCRIWRDLSN 316 ++ S S D ++W+ N Sbjct: 420 VICSVSEDNIMQVWQMAEN 438 >3CFV-B nrPDB Length = 414 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 63/276 (22%), Positives = 113/276 (40%), Gaps = 42/276 (15%) Query: 96 PIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVD 155 P + H++E + +WN + LS+S D ++ +W + P E K+VD Sbjct: 171 PDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWD---------INAGPKE-GKIVD 220 Query: 156 PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 215 K FTG S V + ++L S + + ++D R + ++ Sbjct: 221 -------AKAIFTGHSA---VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHL 270 Query: 216 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 + E FN Y +++ATG D + +WD+R L +LH Sbjct: 271 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL------------KLHTFE-- 316 Query: 276 NEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSI 335 +H I +V WSPH+ IL S+ D +W DLS G +++ + ++ D + Sbjct: 317 -----SHKDEIFQVHWSPHNETILASSGTDRRLNVW-DLSKIGEEQSAE-DAEDGPPELL 369 Query: 336 FNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 F H+ + W+ +P + S + D + +W Sbjct: 370 FIHGGHTAKISDFSWNP-NEPWVICSVSEDNIMQIW 404 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 61/259 (23%), Positives = 109/259 (42%), Gaps = 38/259 (14%) Query: 64 FDLAWNESHENQVLVAQGDGTLRLFDTTF--KEFPI----AIFKEHEREVFSCNWNLVNR 117 + L+WN + +L A D T+ L+D KE I AIF H V W+L++ Sbjct: 183 YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHE 242 Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 177 F S + D + IW + T +P + +VD A + NC+ Sbjct: 243 SLFGSVADDQKLMIW-----DTRSNTTSKP---SHLVDAHTAEV-------------NCL 281 Query: 178 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 237 F+P+ + ++ + S + +L+D+R K + F H E ++ + ++A Sbjct: 282 ---SFNPYSEFILATGSADKTVALWDLRNLKLK-LHTFESHKD-EIFQVHWSPHNETILA 336 Query: 238 TGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSN 297 + G D + +WD+ + + +SA P +L I H I +W+P+ Sbjct: 337 SSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF------IHGGHTAKISDFSWNPNEPW 390 Query: 298 ILMSASYDMTCRIWRDLSN 316 ++ S S D +IW+ N Sbjct: 391 VICSVSEDNIMQIWQMAEN 409 >5M25-A nrPDB Length = 434 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 68/163 (41%), Gaps = 28/163 (17%) Query: 186 DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAI 245 D NL++S S + ++D+ SGK HS C+FN +V +G D ++ Sbjct: 198 DSNLLVSASDDKTLKIWDVS--SGKCLKTLKGHSNY-VFCCNFNPQSNLIV-SGSFDESV 253 Query: 246 RIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYD 305 RIWD++ C+ +P AH + V ++ ++++S+SYD Sbjct: 254 RIWDVK-------------------TGKCLKTLP-AHSDPVSAVHFN-RDGSLIVSSSYD 292 Query: 306 MTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGA 348 CRIW S K D S F+ + +++ A Sbjct: 293 GLCRIWDTASGQCLKTLI---DDDNPPVSFVKFSPNGKYILAA 332 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 43/187 (22%), Positives = 79/187 (42%), Gaps = 34/187 (18%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 122 + D+AW+ S N ++ A D TL+++D + + + K H VF CN+N +S Sbjct: 190 ISDVAWS-SDSNLLVSASDDKTLKIWDVSSGKC-LKTLKGHSNYVFCCNFN-PQSNLIVS 246 Query: 123 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQF 182 S+D S++IW + L TL DP++A+ + Sbjct: 247 GSFDESVRIWDVKTGKCLKTLPAHS-------DPVSAVHFNR------------------ 281 Query: 183 SPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVD 242 D +L++S S + ++D SG+ + F+ Y++A +D Sbjct: 282 ---DGSLIVSSSYDGLCRIWDT--ASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLD 335 Query: 243 NAIRIWD 249 N +++WD Sbjct: 336 NTLKLWD 342 >6Q8F-A nrPDB Length = 514 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 83/201 (41%), Gaps = 51/201 (25%) Query: 180 AQFSPHDQNLVLSCSGNSYASLFDIRLPSGK--------NQNNFLVHSGLEALTCDFNKY 231 A+FSP Q LV + S + + +++ +GK Q+NF++ +A+ C Sbjct: 221 ARFSPDGQYLV-TGSVDGFIEVWN--FTTGKIRKDLKYQAQDNFMMMD--DAVLCMCFSR 275 Query: 232 RPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTW 291 ++ATG D I++W I+ + C+ AH + +++ Sbjct: 276 DTEMLATGAQDGKIKVWKIQ-------------------SGQCLRRFERAHSKGVTCLSF 316 Query: 292 SPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 351 S S IL SAS+D T RI S KE F HS FV A ++ Sbjct: 317 SKDSSQIL-SASFDQTIRIHGLKSGKTLKE----------------FRGHSSFVNEATFT 359 Query: 352 LWGKPGYVASTAWDGNLFVWN 372 G Y+ S + DG + +WN Sbjct: 360 QDGH--YIISASSDGTVKIWN 378 >2H9P-A nrPDB Length = 329 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 68/163 (41%), Gaps = 28/163 (17%) Query: 186 DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAI 245 D NL++S S + ++D+ SGK HS C+FN +V+ G D ++ Sbjct: 93 DSNLLVSASDDKTLKIWDVS--SGKCLKTLKGHSNY-VFCCNFNPQSNLIVS-GSFDESV 148 Query: 246 RIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYD 305 RIWD++ C+ +P AH + V ++ ++++S+SYD Sbjct: 149 RIWDVKT-------------------GKCLKTLP-AHSDPVSAVHFN-RDGSLIVSSSYD 187 Query: 306 MTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGA 348 CRIW S K D S F+ + +++ A Sbjct: 188 GLCRIWDTASGQCLKTLI---DDDNPPVSFVKFSPNGKYILAA 227 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 43/185 (23%), Positives = 78/185 (42%), Gaps = 34/185 (18%) Query: 65 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSS 124 D+AW+ S N ++ A D TL+++D + + + K H VF CN+N +S S Sbjct: 87 DVAWS-SDSNLLVSASDDKTLKIWDVSSGKC-LKTLKGHSNYVFCCNFN-PQSNLIVSGS 143 Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 +D S++IW + L TL DP++A+ + Sbjct: 144 FDESVRIWDVKTGKCLKTLPAHS-------DPVSAVHFNR-------------------- 176 Query: 185 HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNA 244 D +L++S S + ++D SG+ + F+ Y++A +DN Sbjct: 177 -DGSLIVSSSYDGLCRIWDT--ASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNT 232 Query: 245 IRIWD 249 +++WD Sbjct: 233 LKLWD 237 >6QX9-4B nrPDB Length = 522 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 20/78 (25%) Query: 234 YVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP 293 Y +ATG DN ++WD+R C+ IP AH + V + P Sbjct: 420 YHIATGSGDNTCKVWDLR-------------------QRRCVYTIP-AHQNLVTGVKFEP 459 Query: 294 HHSNILMSASYDMTCRIW 311 H N L++ +YD T +IW Sbjct: 460 IHGNFLLTGAYDNTAKIW 477 >5MZH-A nrPDB Length = 452 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 62/286 (21%), Positives = 118/286 (41%), Gaps = 45/286 (15%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 122 L + A+N+S ++ + D T ++++T F + + H+ V++ +N ++ Sbjct: 97 LTNCAFNKS-GDRFITGSYDRTCKVWNT-FTGEEVFTLEGHKNVVYAIAFNNPYGDKIVT 154 Query: 123 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISK---NRNCVYQ 179 S+D + K+W Q TL EI + + I+ S +K + Sbjct: 155 GSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQER 214 Query: 180 AQFSPHDQ-----------NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDF 228 A + H +L+++ S + + L+D+R +G+ + H G E + F Sbjct: 215 ATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVR--TGQCVHVLSGHRG-EVSSTQF 271 Query: 229 NKYRPYVVATGGVDNAIRIWDIR--------------MLNKNESATIKRTVPGQLHNSS- 273 N Y +V +G +D R+WD+R +L+ A + V S+ Sbjct: 272 N-YAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSAR 330 Query: 274 --------CINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 C + + G I KV ++P + L++AS D TCR+W Sbjct: 331 LYHTLTGVCQHTLVGHEG-EISKVAFNPQGTR-LITASSDKTCRLW 374 >6QX9-5O nrPDB Length = 357 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 70/300 (23%), Positives = 121/300 (40%), Gaps = 63/300 (21%) Query: 94 EFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIW---------SPLRKQS--LMT 142 + PI + HE EV+ C ++ N S+ +D I +W + L+ S +M Sbjct: 56 QAPIMLLSGHEGEVYCCKFH-PNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVME 114 Query: 143 L---TPRPLEITKMVDPLNAI-----ILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCS 194 L T + + D A+ + K G + N Y A+ P LV + S Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ---LVCTGS 171 Query: 195 GNSYASLFDIRLPSGKN--QNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRM 252 + L+DIR + QN + V L FN ++ +GG+DN I++WD+R Sbjct: 172 DDGTVKLWDIRKKAAIQTFQNTYQV------LAVTFNDTSDQII-SGGIDNDIKVWDLR- 223 Query: 253 LNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 312 +N+ R H ++ ++ S S L+S + D T R+W Sbjct: 224 --QNKLTYTMR-----------------GHADSVTGLSLSSEGS-YLLSNAMDNTVRVW- 262 Query: 313 DLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 D+ KE +G++ NF ++ + WS G +A+ + D ++VW+ Sbjct: 263 DVRPFAPKE----RCVKIFQGNVHNFEKN---LLRCSWSPDGSK--IAAGSADRFVYVWD 313 >5OQL-d nrPDB Length = 446 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 70/338 (20%), Positives = 123/338 (36%), Gaps = 78/338 (23%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 122 ++ + +++ N + GDG ++++D T ++ H V + N + LS Sbjct: 69 VYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTF--TNDKKLLS 126 Query: 123 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT-GISKNRNCVY--- 178 + DG IK+W P S T P+ + P ++ + + T S + C+ Sbjct: 127 CATDG-IKLWDPYASPSNTT----PIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWD 181 Query: 179 --------------------QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH 218 F+ + +++ S + + LFD+R N V Sbjct: 182 LEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLR-------TNMPVI 234 Query: 219 SGLEALTCD---FNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 + C+ FN +A D+ I I+D R +K + Sbjct: 235 KTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDK------------------AL 276 Query: 276 NEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSI 335 N I H A+ V +SP L+S SYD T R+WR DA Sbjct: 277 N-IQKGHVAAVMDVEFSPTGEE-LVSGSYDRTIRLWR---------------RDAGHSRD 319 Query: 336 FNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 T+ + VF W++ K Y+ + + DGN+ +W Sbjct: 320 VYHTKRMQRVFRTMWTMDSK--YILTGSDDGNVRLWRA 355 >6EMK-B nrPDB Length = 303 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 86/208 (41%), Gaps = 40/208 (19%) Query: 71 SHENQVLVAQGDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 +++ ++L G +RL+D T P+A F+ H V S ++ NR ++SS DG+I Sbjct: 41 TNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTI 99 Query: 130 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRN------------CV 177 K+W +R S+ PR K P+N +++ IS +R+ C Sbjct: 100 KVWD-VRSPSI----PRNY---KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCT 151 Query: 178 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK----NQNNFLVHSGLEALTCDFNKYRP 233 + Q +P D + S S S S+ G N S L+ +T F + Sbjct: 152 H--QLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT-KFRAHST 208 Query: 234 YV-----------VATGGVDNAIRIWDI 250 Y+ +AT D+ R+W I Sbjct: 209 YITRILLSSDVKHLATCSADHTARVWSI 236 Score = 28.1 bits (61), Expect = 6.6, Method: Compositional matrix adjust. Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 2/62 (3%) Query: 190 VLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWD 249 +L+ +G+ L+DIR + +F H G + F + ++V T D I++WD Sbjct: 46 LLATAGHQNVRLYDIRTTNPNPVASFEGHRG-NVTSVSFQQDNRWMV-TSSEDGTIKVWD 103 Query: 250 IR 251 +R Sbjct: 104 VR 105 >5FL8-q nrPDB Length = 515 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/182 (21%), Positives = 75/182 (41%), Gaps = 45/182 (24%) Query: 149 EITKMVDPLNAIILKK--KSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRL 206 +IT + P +K +S + I+ + + + + F+PH + +++ +G++ A ++D Sbjct: 116 QITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCD- 174 Query: 207 PSGKNQNNFLVHSGLEALTCDFN-----KYRP--YVVATGGVDNAIRIWDIRMLNKNESA 259 + + L +N + P V+ATG +DN IR+WD + Sbjct: 175 ----------TQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPK-------- 216 Query: 260 TIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH------SNILMSASYDMTCRIWRD 313 + C+ + H I ++W P H L S+S D T +IW Sbjct: 217 -----------SGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDT 265 Query: 314 LS 315 +S Sbjct: 266 VS 267 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 45/187 (24%), Positives = 76/187 (40%), Gaps = 47/187 (25%) Query: 69 NESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGS 128 N + E ++ A D T+ L++ PIA H++ V ++ R +S+S+D S Sbjct: 367 NGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRY-IVSASFDNS 425 Query: 129 IKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQN 188 IK+W + + T F G + VYQ +S D Sbjct: 426 IKLWDGRDGKFIST------------------------FRG---HVASVYQVAWS-SDCR 457 Query: 189 LVLSCSGNSYASLFDIR-------LPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGV 241 L++SCS ++ ++D+R LP K+ E T D++ V +GG Sbjct: 458 LLVSCSKDTTLKVWDVRTRKLSVDLPGHKD----------EVYTVDWS-VDGKRVCSGGK 506 Query: 242 DNAIRIW 248 D +R+W Sbjct: 507 DKMVRLW 513 Score = 31.6 bits (70), Expect = 0.63, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 42/87 (48%), Gaps = 11/87 (12%) Query: 66 LAWNESHENQVLVAQG--DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVN------R 117 ++W+ E ++A G D T+RL+D + + H + + S +W ++ + Sbjct: 192 VSWSPDGE---VIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSK 248 Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLT 144 SSS DG+IKIW + + T++ Sbjct: 249 PRLASSSKDGTIKIWDTVSRVCQYTMS 275 >4A11-B nrPDB Length = 408 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 39/88 (44%), Gaps = 9/88 (10%) Query: 225 TCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVP-GQLHNSSCINEIPNAHG 283 T D + +GG D I ++D+ ++ T K G+ H P+ H Sbjct: 48 TLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDH--------PDVHR 99 Query: 284 LAIRKVTWSPHHSNILMSASYDMTCRIW 311 ++ V W PH + + S+S+D T ++W Sbjct: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVW 127 Score = 30.8 bits (68), Expect = 0.88, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 23/43 (53%), Gaps = 1/43 (2%) Query: 269 LHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 L + SC + I H I V+WSP + IL +AS D ++W Sbjct: 173 LKSGSC-SHILQGHRQEILAVSWSPRYDYILATASADSRVKLW 214 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 50/246 (20%), Positives = 83/246 (33%), Gaps = 36/246 (14%) Query: 103 HEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIIL 162 H V + W + F SSS+D ++K+W +L T E T Sbjct: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWD---TNTLQTADVFNFEET----------- 143 Query: 163 KKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLE 222 VY SP L G + L SG + H E Sbjct: 144 --------------VYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHR-QE 188 Query: 223 ALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAH 282 L ++ Y++AT D+ +++WD+R S + S + AH Sbjct: 189 ILAVSWSPRYDYILATASADSRVKLWDVR----RASGCLITLDQHNGKKSQAVESANTAH 244 Query: 283 GLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFT--Q 340 + + ++ + L++ D R+W + + Y ++ KG F + Sbjct: 245 NGKVNGLCFTSDGLH-LLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGC 303 Query: 341 HSEFVF 346 SEFVF Sbjct: 304 SSEFVF 309 >5NNZ-B nrPDB Length = 415 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 60/255 (23%), Positives = 99/255 (38%), Gaps = 47/255 (18%) Query: 76 VLVAQG--DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWS 133 LVA G D T +L+D E + + H E+ S ++N + ++ S+D ++ +W Sbjct: 190 TLVATGSMDTTAKLWDIQNGE-EVYTLRGHSAEIISLSFN-TSGDRIITGSFDHTVVVWD 247 Query: 134 PLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISK-----NRNCVYQAQFSPHDQN 188 + + L EI+ + ++ S K N CV A + HD Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCV--ATLTGHDDE 305 Query: 189 LVLSC-----------SGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 237 ++ SC S + A +F + K H G E FN +++ Sbjct: 306 ILDSCFDYTGKLIATASADGTARIFSA--ATRKCIAKLEGHEG-EISKISFNPQGNHLL- 361 Query: 238 TGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSN 297 TG D RIWD + GQ C+ ++ H I ++ + N Sbjct: 362 TGSSDKTARIWDAQ--------------TGQ-----CL-QVLEGHTDEIFSCAFN-YKGN 400 Query: 298 ILMSASYDMTCRIWR 312 I+++ S D TCRIWR Sbjct: 401 IVITGSKDNTCRIWR 415 >2HES-X nrPDB Length = 330 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 44/94 (46%), Gaps = 12/94 (12%) Query: 279 PNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNF 338 AH AIR V W P H+++L + S+D T IW + A T++ + +G Sbjct: 54 ETAHKKAIRSVAWRP-HTSLLAAGSFDSTVSIWA--KEESADRTFEMDLLAIIEG----- 105 Query: 339 TQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H V G WS Y+A+ + D ++++W Sbjct: 106 --HENEVKGVAWS--NDGYYLATCSRDKSVWIWE 135 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 17/84 (20%) Query: 234 YVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP 293 Y +AT D ++ IW+ +ES CI+ + H ++ V W P Sbjct: 120 YYLATCSRDKSVWIWET-----DESG----------EEYECIS-VLQEHSQDVKHVIWHP 163 Query: 294 HHSNILMSASYDMTCRIWRDLSND 317 + +L S+SYD T RIW+D +D Sbjct: 164 SEA-LLASSSYDDTVRIWKDYDDD 186 >5I2T-A nrPDB Length = 742 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 2/71 (2%) Query: 74 NQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWS 133 ++V+ A DG ++++D T F +A F+EH V + + Q SSS DG+++ W Sbjct: 383 SRVVTASEDGKIKVWDIT-SGFCLATFEEHTSSVTAVQF-AKRGQVMFSSSLDGTVRAWD 440 Query: 134 PLRKQSLMTLT 144 +R ++ T T Sbjct: 441 LIRYRNFRTFT 451 >4YCZ-A nrPDB Length = 876 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 39/136 (28%), Positives = 58/136 (42%), Gaps = 33/136 (24%) Query: 236 VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWS-PH 294 +AT D I+I++I + E+ + T+ G H A+ V+W+ P Sbjct: 33 LATCSSDRTIKIFEI----EGETQRLTETLKG--------------HDGAVWCVSWAHPK 74 Query: 295 HSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG 354 + NIL SA YD IWR+L +GA + IF+F H V WS Sbjct: 75 YGNILASAGYDGKVLIWREL--NGAWQ------------RIFDFALHKASVNVVSWSPHE 120 Query: 355 KPGYVASTAWDGNLFV 370 +A + DGN+ V Sbjct: 121 AGCLLACASSDGNVSV 136 Score = 34.7 bits (78), Expect = 0.064, Method: Compositional matrix adjust. Identities = 58/251 (23%), Positives = 98/251 (39%), Gaps = 63/251 (25%) Query: 82 DGTLRLFDTTFKEFPIA-IFKEHEREVFSCNWNLVNRQNFLSSS-WDGSIKIWSPLRKQS 139 D T+++F+ + + K H+ V+ +W N L+S+ +DG + IW Sbjct: 39 DRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWR------ 92 Query: 140 LMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSC-SGNSY 198 E+ + L K S +S +SPH+ +L+C S + Sbjct: 93 ---------ELNGAWQRIFDFALHKASVNVVS----------WSPHEAGCLLACASSDGN 133 Query: 199 ASLFDIRLPSGKNQNNFLVHS-GLEALTCDFNKYRPYVVA--------------TGGVDN 243 S+ + R S ++ + F H G+ +++ +V+ TGG DN Sbjct: 134 VSVLEFRDNSWEH-SIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDN 192 Query: 244 AIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIP-NAHGLAIRKVTWSPH--HSNILM 300 A++IW + AT N+ + P H +R V WSP + + Sbjct: 193 ALKIW------AYDPAT----------NTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIA 236 Query: 301 SASYDMTCRIW 311 SAS D T RIW Sbjct: 237 SASEDRTVRIW 247 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 48/232 (20%), Positives = 82/232 (35%), Gaps = 65/232 (28%) Query: 190 VLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPY--VVATGGVDNAIRI 247 + +CS + +F+I + + H G A+ C + Y ++A+ G D + I Sbjct: 33 LATCSSDRTIKIFEIEGETQRLTETLKGHDG--AVWCVSWAHPKYGNILASAGYDGKVLI 90 Query: 248 WDIRMLNKN---------ESATIKRTVPGQLHNSSCI---------------------NE 277 W R LN A++ V H + C+ + Sbjct: 91 W--RELNGAWQRIFDFALHKASVN-VVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHS 147 Query: 278 IPNAHGLAIRKVTWSPHHS----------------NILMSASYDMTCRIWRDLSNDGAKE 321 I +AHGL + V+W+P S ++ D +IW + D A Sbjct: 148 IFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIW---AYDPATN 204 Query: 322 TYKTNSTDATKGSIFNFTQHSEFVFGADWS-LWGKPGYVASTAWDGNLFVWN 372 TYK T H+++V WS + Y+AS + D + +W Sbjct: 205 TYKLEREP--------LTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWT 248 >4LG8-A nrPDB Length = 354 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 86/201 (42%), Gaps = 24/201 (11%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 S N++L D + +FD + ++ +A K H ++V S ++ ++ S+S D +I+ Sbjct: 82 SDTNKILTGGADKNVVVFDKSSEQI-LATLKGHTKKVTSVVFH-PSQDLVFSASPDATIR 139 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKS------FTGISKNR---------- 174 IWS + + +T + L S F+ I R Sbjct: 140 IWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETS 199 Query: 175 NC-VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRP 233 C + AQF P D + + + +S ++D++ N NF HSG +T Sbjct: 200 GCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLK--ERTNVANFPGHSG--PITSIAFSENG 254 Query: 234 YVVATGGVDNAIRIWDIRMLN 254 Y +AT D+++++WD+R L Sbjct: 255 YYLATAADDSSVKLWDLRKLK 275 >5FA5-B nrPDB Length = 367 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 62/295 (21%), Positives = 112/295 (37%), Gaps = 69/295 (23%) Query: 59 TQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKE-FPIAIFKEHERE-VFSCNWNLVN 116 T+ + DL W E +LVA G + L++ E ++ F ++E + + S L + Sbjct: 104 TEAGVADLTW--VGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSS 161 Query: 117 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNC 176 +S S D IK+W L +Q +++ S+ + C Sbjct: 162 GTQAVSGSKDICIKVWD-LAQQVVLS-----------------------SYRAHAAQVTC 197 Query: 177 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVV 236 V SPH ++ LSCS ++ L+D R P +Q + C Y P + Sbjct: 198 VAA---SPHKDSVFLSCSEDNRILLWDTRCPKPASQ-----------IGCSAPGYLPTSL 243 Query: 237 ATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHS 296 A + + ++ ++N + ++ T ++SC+ H + + +SPH Sbjct: 244 AWHPQQSEVFVFG----DENGTVSLVDT-----KSTSCVLSS-AVHSQCVTGLVFSPHSV 293 Query: 297 NILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 351 L S S D + + D++ +F H +FV A WS Sbjct: 294 PFLASLSEDCSLAV-----------------LDSSLSELFRSQAHRDFVRDATWS 331 >5A9Q-0 nrPDB Length = 380 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 3/66 (4%) Query: 70 ESHENQV-LVAQG--DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWD 126 + H NQ +VA G DG L ++D P+++ K HE E++ +++ N ++ + S D Sbjct: 224 DRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSED 283 Query: 127 GSIKIW 132 GS+ W Sbjct: 284 GSLWHW 289 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 14/29 (48%), Positives = 19/29 (65%), Gaps = 1/29 (3%) Query: 224 LTC-DFNKYRPYVVATGGVDNAIRIWDIR 251 L C D + + +VVATGG D + IWD+R Sbjct: 220 LHCVDRHPNQQHVVATGGQDGMLSIWDVR 248 >5WLC-LO nrPDB Length = 923 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 2/71 (2%) Query: 74 NQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWS 133 ++V+ A DG ++++D T F +A F+EH V + + Q SSS DG+++ W Sbjct: 358 SRVVTASEDGKIKVWDIT-SGFCLATFEEHTSSVTAVQF-AKRGQVMFSSSLDGTVRAWD 415 Query: 134 PLRKQSLMTLT 144 +R ++ T T Sbjct: 416 LIRYRNFRTFT 426 >6G51-g nrPDB Length = 317 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 92/206 (44%), Gaps = 42/206 (20%) Query: 82 DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLM 141 DGTLRL+D T F H ++V S ++ NRQ +S S D +IK+W+ L Sbjct: 84 DGTLRLWDLTTGT-TTRRFVGHTKDVLSVAFSSDNRQ-IVSGSRDKTIKLWNTL------ 135 Query: 142 TLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQN-LVLSCSGNSYAS 200 + ++ +S S+ +CV +FSP+ N +++SC + Sbjct: 136 --------------GVCKYTVQDESH---SEWVSCV---RFSPNSSNPIIVSCGWDKLVK 175 Query: 201 LFDIRLPSGKNQNNFLVHSG-LEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESA 259 +++ L + K + N + H+G L +T + + A+GG D +WD+ NE Sbjct: 176 VWN--LANCKLKTNHIGHTGYLNTVTVSPDG---SLCASGGKDGQAMLWDL-----NEGK 225 Query: 260 TIKRTVPGQLHNSSCINEIPNAHGLA 285 + G + N+ C + PN + L Sbjct: 226 HLYTLDGGDIINALCFS--PNRYWLC 249 Score = 28.5 bits (62), Expect = 4.5, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 19/95 (20%) Query: 281 AHGLAIRKVTWSPHHSNILMSASYDMTCRIW---RDLSNDGAKETYKTNSTDATKGSIFN 337 H + ++ +P ++++SAS D T +W RD +N G + A +G Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-------ALRG---- 61 Query: 338 FTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 HS FV +D + + S +WDG L +W+ Sbjct: 62 ---HSHFV--SDVVISSDGQFALSGSWDGTLRLWD 91 >6EOJ-D nrPDB Length = 470 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 52/263 (19%), Positives = 107/263 (40%), Gaps = 56/263 (21%) Query: 51 IVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRL--FDTTFKEFPIAIFKEHEREVF 108 + E+++ T+ + D+A++ S++++ + D L++ F +E + H +V Sbjct: 169 VKEIDAAHTE-SIRDMAFS-SNDSKFVTCSDDNILKIWNFSNGKQE---RVLSGHHWDVK 223 Query: 109 SCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT 168 SC+W+ S+S D +K+W P + + Sbjct: 224 SCDWH-PEMGLIASASKDNLVKLWDPRSGNCI---------------------------S 255 Query: 169 GISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDF 228 I K ++ V + +F P NL+++ S + +FDIR + V + +T ++ Sbjct: 256 SILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY---SMKELMCVRDETDYMTLEW 312 Query: 229 NKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRK 288 + + D +++ +D+ + N NE I IP AH I Sbjct: 313 HPINESMFTLACYDGSLKHFDL-LQNLNEP----------------ILTIPYAHDKCITS 355 Query: 289 VTWSPHHSNILMSASYDMTCRIW 311 ++++P +I +A+ D T R W Sbjct: 356 LSYNP-VGHIFATAAKDRTIRFW 377 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 52/106 (49%), Gaps = 10/106 (9%) Query: 40 LFILEIDRSGRIVEVNSFLTQ-DCLFD------LAWNESHENQVLVAQGDGTLRLFD--T 90 L + D+S R+ ++ + + C+ D L W+ +E+ +A DG+L+ FD Sbjct: 277 LMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQ 336 Query: 91 TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLR 136 E + I H++ + S ++N V F +++ D +I+ W+ R Sbjct: 337 NLNEPILTIPYAHDKCITSLSYNPVGHI-FATAAKDRTIRFWTRAR 381 >4V7E-Bg nrPDB Length = 380 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 52/256 (20%), Positives = 101/256 (39%), Gaps = 54/256 (21%) Query: 100 FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNA 159 + H +V+S +W + +S+S DG + +W+ L Q + K+ P Sbjct: 62 LQGHSGKVYSLDWT-PEKNWIVSASQDGRLIVWNALTSQKTHAI--------KLHCPW-- 110 Query: 160 IILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSG-NSYASLFDIRLPSGKNQNN---- 214 V + F+P+ Q++ +C G +S S+F++ + ++ N Sbjct: 111 -----------------VMECAFAPNGQSV--ACGGLDSACSIFNLSSQADRDGNMPVSR 151 Query: 215 -FLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSS 273 H G A +C + + + TG D +WD+ + + ++ G Sbjct: 152 VLTGHKGY-ASSCQYVPDQETRLITGSGDQTCVLWDV-------TTGQRISIFG------ 197 Query: 274 CINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKG 333 +E P+ H + ++ + ++N+ +S S D T R+W A TY + D Sbjct: 198 --SEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDIN-- 253 Query: 334 SIFNFTQHSEFVFGAD 349 S+ F F G+D Sbjct: 254 SVKFFPDGQRFGTGSD 269 Score = 30.8 bits (68), Expect = 0.93, Method: Compositional matrix adjust. Identities = 34/148 (22%), Positives = 56/148 (37%), Gaps = 15/148 (10%) Query: 6 MQGFSGYG--VQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIV----EVNSFLT 59 + G GY QY P + RL +G + ++ RI E S T Sbjct: 153 LTGHKGYASSCQYVPDQETRLITGSGDQ-------TCVLWDVTTGQRISIFGSEFPSGHT 205 Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQN 119 D L L+ N + N + D T+RL+D + + HE ++ S + + Q Sbjct: 206 ADVL-SLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKF-FPDGQR 263 Query: 120 FLSSSWDGSIKIWSPLRKQSLMTLTPRP 147 F + S DG+ +++ L P Sbjct: 264 FGTGSDDGTCRLFDMRTGHQLQVYNREP 291 Score = 27.3 bits (59), Expect = 9.8, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 19/34 (55%), Gaps = 2/34 (5%) Query: 341 HSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGL 374 HS V+ DW+ + ++ S + DG L VWN L Sbjct: 65 HSGKVYSLDWT--PEKNWIVSASQDGRLIVWNAL 96 >4PSX-B nrPDB Length = 401 Score = 36.6 bits (83), Expect = 0.016, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 8/80 (10%) Query: 182 FSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH-SGLEALT--CDFNKYRPYVVAT 238 FS H NL+ + +SY L+D+R N L H SG E +F+ + VV + Sbjct: 259 FSHHSSNLLAAAGMDSYVYLYDLR-----NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVS 313 Query: 239 GGVDNAIRIWDIRMLNKNES 258 G DN + +WD++ + ++ Sbjct: 314 SGSDNRLMMWDLKQIGAEQT 333 Score = 32.0 bits (71), Expect = 0.45, Method: Compositional matrix adjust. Identities = 20/96 (20%), Positives = 45/96 (46%), Gaps = 11/96 (11%) Query: 164 KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNN--------- 214 K+ +S + + V +FS H +V+S ++ ++D++ + + Sbjct: 285 KEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPEL 344 Query: 215 FLVHSGLEALTCDF--NKYRPYVVATGGVDNAIRIW 248 +VH+G + DF N P++VA+ +N +++W Sbjct: 345 IMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 35/148 (23%), Positives = 63/148 (42%), Gaps = 24/148 (16%) Query: 225 TCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGL 284 T F+ + ++A G+D+ + ++D+R + + LH+ S H Sbjct: 256 TLAFSHHSSNLLAAAGMDSYVYLYDLRNMKE------------PLHHMS-------GHED 296 Query: 285 AIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEF 344 A+ + +S H +++S+ D +W DL GA++T ++ D I H Sbjct: 297 AVNNLEFSTHVDGVVVSSGSDNRLMMW-DLKQIGAEQT-PDDAEDGVPELIMVHAGHRSS 354 Query: 345 VFGADWSLWGK-PGYVASTAWDGNLFVW 371 V D+ L + P VAS + L VW Sbjct: 355 V--NDFDLNPQIPWLVASAEEENILQVW 380 >5Z56-q nrPDB Length = 504 Score = 36.2 bits (82), Expect = 0.023, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 86/201 (42%), Gaps = 24/201 (11%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 S N++L D + +FD + ++ +A K H ++V S ++ ++ S+S D +I+ Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQI-LATLKGHTKKVTSVVFH-PSQDLVFSASPDATIR 289 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKS------FTGISKNR---------- 174 IWS + + +T + L S F+ I R Sbjct: 290 IWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETS 349 Query: 175 NC-VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRP 233 C + AQF P D + + + +S ++D++ N NF HSG +T Sbjct: 350 GCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLK--ERTNVANFPGHSG--PITSIAFSENG 404 Query: 234 YVVATGGVDNAIRIWDIRMLN 254 Y +AT D+++++WD+R L Sbjct: 405 YYLATAADDSSVKLWDLRKLK 425 >3BG0-A nrPDB Length = 316 Score = 36.2 bits (82), Expect = 0.023, Method: Compositional matrix adjust. Identities = 61/279 (21%), Positives = 98/279 (35%), Gaps = 80/279 (28%) Query: 69 NESHENQVLVAQ------------GDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLV 115 + SHE+ + AQ D ++++FD + IA + HE V+ W Sbjct: 9 DTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 Query: 116 NRQNFLSS-SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNR 174 N L+S S+D + IW R++ N K G + Sbjct: 69 MYGNILASCSYDRKVIIW---REE-------------------NGTWEKSHEHAGHDSSV 106 Query: 175 NCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPY 234 N V ++PHD L+L+C + A + +G+ Q + + C+ + P Sbjct: 107 NSVC---WAPHDYGLILACGSSDGA--ISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPA 161 Query: 235 VV-------------------ATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 VV A+GG DN I++W K GQ + Sbjct: 162 VVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW-------------KEEEDGQWKEEQKL 208 Query: 276 NEIPNAHGLAIRKVTWSPH---HSNILMSASYDMTCRIW 311 AH +R V W+P ++ + S S D IW Sbjct: 209 ----EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 243 Score = 28.5 bits (62), Expect = 5.2, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 19/34 (55%), Gaps = 1/34 (2%) Query: 281 AHGLAIRKVTWS-PHHSNILMSASYDMTCRIWRD 313 H + +V W+ P + NIL S SYD IWR+ Sbjct: 55 GHEGPVWQVAWAHPMYGNILASCSYDRKVIIWRE 88 >5WLC-LU nrPDB Length = 489 Score = 36.2 bits (82), Expect = 0.025, Method: Compositional matrix adjust. Identities = 42/168 (25%), Positives = 73/168 (43%), Gaps = 43/168 (25%) Query: 228 FNKYRPYVVATGGVDNAIRIWDIRMLNKNES--ATIKRTV----PGQLHNSSCINEIPNA 281 FN+ ++A+ G DN+I ++D+R + + T++ P + N NE NA Sbjct: 227 FNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNA 286 Query: 282 -----------------HGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDG-AKETY 323 H A+ V +SP I+ + SYD + RI++ +N G ++E Y Sbjct: 287 YYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIV-TGSYDKSIRIYK--TNHGHSREIY 343 Query: 324 KTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 T+ + VF +S+ K Y+ S + DGN+ +W Sbjct: 344 --------------HTKRMQHVFQVKYSMDSK--YIISGSDDGNVRLW 375 >2AQ5-A nrPDB Length = 402 Score = 35.8 bits (81), Expect = 0.034, Method: Compositional matrix adjust. Identities = 24/119 (20%), Positives = 51/119 (42%), Gaps = 10/119 (8%) Query: 36 GNGKLFILEIDRSGRIVEVNSFLTQDC--LFDLAWNESHENQVLVAQGDGTLRLFDTT-- 91 G G +L + ++GR+ + + + D+AW ++N + D T+ +++ Sbjct: 55 GGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDG 114 Query: 92 -----FKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTP 145 +E P+ + H + V W+ + LS+ D I +W +++TL P Sbjct: 115 GLVLPLRE-PVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGP 172 Score = 31.2 bits (69), Expect = 0.85, Method: Compositional matrix adjust. Identities = 10/32 (31%), Positives = 16/32 (50%) Query: 281 AHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 312 H + + W PH+ N++ S S D T +W Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWE 110 >4OWR-A nrPDB Length = 339 Score = 35.4 bits (80), Expect = 0.036, Method: Compositional matrix adjust. Identities = 29/146 (19%), Positives = 61/146 (41%), Gaps = 15/146 (10%) Query: 44 EIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAI-FKE 102 E+ SG+ + + + D+ W++ ++V A D T +++D + + AI + Sbjct: 41 EVQDSGQTIPKAQQMHTGPVLDVCWSDD-GSKVFTASCDKTAKMWDLSSNQ---AIQIAQ 96 Query: 103 HEREVFSCNW-NLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT-PRPLEITKMVDPLNAI 160 H+ V + +W N ++ SWD ++K W +M L P ++ P+ + Sbjct: 97 HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVV 156 Query: 161 ILKKKSFTGISKNRNCVYQAQFSPHD 186 ++ VYQ + P + Sbjct: 157 ATAERGLI--------VYQLENQPSE 174 >6N9G-C nrPDB Length = 353 Score = 35.4 bits (80), Expect = 0.042, Method: Compositional matrix adjust. Identities = 59/253 (23%), Positives = 94/253 (37%), Gaps = 55/253 (21%) Query: 100 FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPL--RKQSLMTL----------TPRP 147 K H +V +W +++ +SSS DG + +W K+ +T+ P Sbjct: 59 LKGHGNKVLCMDW-CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117 Query: 148 LEIT-------KMVDPL-----NAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSG 195 I V PL + KKKS ++ + N + F+ D +L+ SG Sbjct: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKS---VAMHTNYLSACSFTNSDMQ-ILTASG 173 Query: 196 NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRP-YVVATGGVDNAIRIWDIRMLN 254 + +L+D+ SG+ +F H G + L D +GG D +WD+R Sbjct: 174 DGTCALWDVE--SGQLLQSFHGH-GADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR--- 227 Query: 255 KNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDL 314 GQ C+ H + V + P + S S D TCR++ DL Sbjct: 228 -----------SGQ-----CVQAFET-HESDVNSVRYYP-SGDAFASGSDDATCRLY-DL 268 Query: 315 SNDGAKETYKTNS 327 D Y S Sbjct: 269 RADREVAIYSKES 281 >3JRO-A nrPDB Length = 753 Score = 35.0 bits (79), Expect = 0.051, Method: Compositional matrix adjust. Identities = 33/137 (24%), Positives = 55/137 (40%), Gaps = 31/137 (22%) Query: 237 ATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH-- 294 TGG DN ++IW + + ++ ++ T+ G H +R V WSP Sbjct: 174 VTGGADNLVKIW--KYNSDAQTYVLESTLEG--------------HSDWVRDVAWSPTVL 217 Query: 295 HSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG 354 + L S S D TC IW + N K ++ + + ++ A WSL G Sbjct: 218 LRSYLASVSQDRTCIIWT-----------QDNEQGPWKKTLLKEEKFPDVLWRASWSLSG 266 Query: 355 KPGYVASTAWDGNLFVW 371 +A + D + +W Sbjct: 267 --NVLALSGGDNKVTLW 281 >3FM0-A nrPDB Length = 345 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 41/94 (43%), Gaps = 20/94 (21%) Query: 226 CDFNKYRPY--VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHG 283 C F + P ++A+ G D IRIW + I ++V + H Sbjct: 19 CWFLAWNPAGTLLASCGGDRRIRIW-----GTEGDSWICKSV------------LSEGHQ 61 Query: 284 LAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND 317 +RKV WSP N L SAS+D T IW+ +D Sbjct: 62 RTVRKVAWSP-CGNYLASASFDATTCIWKKNQDD 94 >3DM0-A nrPDB Length = 694 Score = 35.0 bits (79), Expect = 0.059, Method: Compositional matrix adjust. Identities = 64/255 (25%), Positives = 102/255 (40%), Gaps = 41/255 (16%) Query: 82 DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRK---- 137 DG LRL+D F H ++V S ++L NRQ +S+S D +IK+W+ L + Sbjct: 451 DGELRLWDLA-AGVSTRRFVGHTKDVLSVAFSLDNRQ-IVSASRDRTIKLWNTLGECKYT 508 Query: 138 -----------QSLMTLTPRPLEIT-------KMVDPLNAIILKKKSFTGISKNRNCVYQ 179 S + +P L+ T K V N K +S ++ + V Sbjct: 509 ISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRST--LAGHTGYVST 566 Query: 180 AQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATG 239 SP D +L S + L+D L GK + +S + AL N+Y ++ A Sbjct: 567 VAVSP-DGSLCASGGKDGVVLLWD--LAEGKKLYSLEANSVIHALCFSPNRY--WLCA-- 619 Query: 240 GVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVT---WSPHHS 296 ++ I+IWD+ + E + + ++S P A + T WS S Sbjct: 620 ATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSG----PAATKRKVIYCTSLNWSADGS 675 Query: 297 NILMSASYDMTCRIW 311 L S D R+W Sbjct: 676 T-LFSGYTDGVIRVW 689 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 23/92 (25%), Positives = 39/92 (42%), Gaps = 13/92 (14%) Query: 281 AHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQ 340 AH + + +++I++SAS D + +W+ +D A + T Sbjct: 380 AHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQR-----------RLTG 428 Query: 341 HSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 HS FV D L + S +WDG L +W+ Sbjct: 429 HSHFV--EDVVLSSDGQFALSGSWDGELRLWD 458 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 35/61 (57%), Gaps = 3/61 (4%) Query: 75 QVLVAQGDGTLRLFDTTFK-EFPIAIFKEHEREVFSCNWNLVN--RQNFLSSSWDGSIKI 131 Q++ A D T++L++T + ++ I+ E R+ SC N + +S+SWD ++K+ Sbjct: 486 QIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKV 545 Query: 132 W 132 W Sbjct: 546 W 546 >1VYH-C nrPDB Length = 410 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 4/64 (6%) Query: 188 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 247 +LSC+ + ++D + N H + DF+K PYVV TG VD +++ Sbjct: 351 KFILSCADDKTLRVWDYKNKRCMKTLNAHEHF---VTSLDFHKTAPYVV-TGSVDQTVKV 406 Query: 248 WDIR 251 W+ R Sbjct: 407 WECR 410 Score = 28.1 bits (61), Expect = 7.0, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 34/77 (44%), Gaps = 21/77 (27%) Query: 235 VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 ++A+ D I++WD + RT+ G HN S ++ +PN Sbjct: 164 LLASCSADMTIKLWDFQGFE------CIRTMHGHDHNVSSVSIMPNG------------- 204 Query: 295 HSNILMSASYDMTCRIW 311 + ++SAS D T ++W Sbjct: 205 --DHIVSASRDKTIKMW 219 >3JZG-A nrPDB Length = 402 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 44/233 (18%), Positives = 99/233 (42%), Gaps = 23/233 (9%) Query: 150 ITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSG 209 I ++++P+ +K G N + + +F P D NL+LS S + L++I+ + Sbjct: 132 IIRIINPITMQCIKHYVGHG-----NAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL 186 Query: 210 KNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI---RMLNK-------NESA 259 + E L+ D++ +++ G+D+++++W I RM+N N + Sbjct: 187 VAIFGGVEGHRDEVLSADYDLLGEKIMSC-GMDHSLKLWRINSKRMMNAIKESYDYNPNK 245 Query: 260 TIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGA 319 T + + ++H + H + V W ++++S S + W+ + Sbjct: 246 TNRPFISQKIHFPDFSTR--DIHRNYVDCVRWL---GDLILSKSCENAIVCWKPGKMEDD 300 Query: 320 KETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + K + ++ T F+++Q + W K + + G L+VW+ Sbjct: 301 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQV--GKLYVWD 351 >3JRP-A nrPDB Length = 379 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 30/119 (25%), Positives = 48/119 (40%), Gaps = 29/119 (24%) Query: 238 TGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH--H 295 TGG DN ++IW + + ++ ++ T+ G H +R V WSP Sbjct: 177 TGGADNLVKIW--KYNSDAQTYVLESTLEG--------------HSDWVRDVAWSPTVLL 220 Query: 296 SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG 354 + L S S D TC IW + N K ++ + + ++ A WSL G Sbjct: 221 RSYLASVSQDRTCIIWT-----------QDNEQGPWKKTLLKEEKFPDVLWRASWSLSG 268 >4BTS-AR nrPDB Length = 343 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 35/131 (26%), Positives = 50/131 (38%), Gaps = 27/131 (20%) Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMS 301 D +R+WD+R T KR V H + V +SP + IL S Sbjct: 97 DKTLRLWDLRT-----GTTYKRFV---------------GHQSEVYSVAFSPDNRQIL-S 135 Query: 302 ASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVAS 361 A + ++W L K N +D + ++S + A+ P Y AS Sbjct: 136 AGAEREIKLWNILGECKFSSAEKENHSDWV-----SCVRYSPIMKSANKVQPFAP-YFAS 189 Query: 362 TAWDGNLFVWN 372 WDG L VWN Sbjct: 190 VGWDGRLKVWN 200 >5A9Q-7 nrPDB Length = 360 Score = 32.7 bits (73), Expect = 0.24, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 24/95 (25%) Query: 227 DFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAI 286 DF+ R +AT D ++++WD K+ES T + H+ S + Sbjct: 21 DFHGRR---MATCSSDQSVKVWD-----KSESGDWHCTASWKTHSGS------------V 60 Query: 287 RKVTWS-PHHSNILMSASYDMTCRIWRDL---SND 317 +VTW+ P +L S S+D T +W ++ SND Sbjct: 61 WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESND 95 >4BZK-B nrPDB Length = 297 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 30/119 (25%), Positives = 48/119 (40%), Gaps = 29/119 (24%) Query: 238 TGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH--H 295 TGG DN ++IW + + ++ ++ T+ G H +R V WSP Sbjct: 175 TGGADNLVKIW--KYNSDAQTYVLESTLEG--------------HSDWVRDVAWSPTVLL 218 Query: 296 SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG 354 + L S S D TC IW + N K ++ + + ++ A WSL G Sbjct: 219 RSYLASVSQDRTCIIWT-----------QDNEQGPWKKTLLKEEKFPDVLWRASWSLSG 266 >4G56-B nrPDB Length = 357 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 51/259 (19%), Positives = 87/259 (33%), Gaps = 63/259 (24%) Query: 115 VNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMV-------DPLNAIILKK--- 164 V+ + L +S G++++W L K+SL+ E +V D A+ K Sbjct: 103 VSEKGILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFS 162 Query: 165 ------------KSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQ 212 KS+ S NCV P + LSC + L+D R P + Sbjct: 163 VKVWDLSQKAVLKSYNAHSSEVNCVAAC---PGKDTIFLSCGEDGRILLWDTRKPKPATR 219 Query: 213 NNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNS 272 +F + + ++ + A G + + +I+ + +++ + Sbjct: 220 IDFCASDTIPT-SVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAV----------- 267 Query: 273 SCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATK 332 H I + +S H S L S S D T + DA Sbjct: 268 ---------HSQNITGLAYSYHSSPFLASISEDCTVAV-----------------LDADF 301 Query: 333 GSIFNFTQHSEFVFGADWS 351 +F H +FV G WS Sbjct: 302 SEVFRDLSHRDFVTGVAWS 320 >3F3P-A nrPDB Length = 351 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 4/61 (6%) Query: 281 AHGLAIRKVTW-SPHHSNILMSASYDMTCRIWR---DLSNDGAKETYKTNSTDATKGSIF 336 AH +I + W SP + I+ SASYD T ++W D + K + + +KGS++ Sbjct: 55 AHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLY 114 Query: 337 N 337 + Sbjct: 115 S 115 >5GAN-H nrPDB Length = 465 Score = 32.7 bits (73), Expect = 0.30, Method: Compositional matrix adjust. Identities = 47/198 (23%), Positives = 83/198 (41%), Gaps = 42/198 (21%) Query: 66 LAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKE---HEREVFSCNWNLVNRQNFL- 121 + W+ NQ++ DG ++ F + +E + + + HER + ++ + F+ Sbjct: 224 IDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGK--FIG 281 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGI-SKNRNCVYQA 180 S+S D + ++W Q L+ L++ G+ S + C Sbjct: 282 SASHDMTWRLWDASTHQELL--------------------LQEGHDKGVFSLSFQC---- 317 Query: 181 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG-LEALTCDFNKYRPYVVATG 239 D +LV S +S + L+DIR SG HS + + N Y+ VATG Sbjct: 318 -----DGSLVCSGGMDSLSMLWDIR--SGSKVMTLAGHSKPIYTVAWSPNGYQ---VATG 367 Query: 240 GVDNAIRIWDIRMLNKNE 257 G D I +WDIR ++ + Sbjct: 368 GGDGIINVWDIRKRDEGQ 385 >5CXC-A nrPDB Length = 510 Score = 32.3 bits (72), Expect = 0.31, Method: Compositional matrix adjust. Identities = 45/214 (21%), Positives = 80/214 (37%), Gaps = 35/214 (16%) Query: 109 SCNWNLVN--RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRP-------LEITKMVDPLNA 159 S +W V+ ++ L++S DG+I WS + + P P ++K ++ Sbjct: 242 SVDWLDVDGHSKHILTASADGAIGFWSASKASA-----PEPDASLLPGAHVSKRRKATSS 296 Query: 160 IILKKKSFTGI-SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF-LV 217 + ++ G+ S + A F P D+ + S S + D L +G+ + L Sbjct: 297 VSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLD--LTTGQVVSTLTLT 354 Query: 218 HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINE 277 H L ++A G I + D R + S R Sbjct: 355 HPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLR-------------- 400 Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 H + ++ SP + L+S S+D TCR+W Sbjct: 401 ---GHANKVVSLSPSPENEYSLVSGSHDGTCRVW 431 >5FVM-C nrPDB Length = 303 Score = 32.3 bits (72), Expect = 0.38, Method: Compositional matrix adjust. Identities = 63/302 (20%), Positives = 121/302 (40%), Gaps = 55/302 (18%) Query: 6 MQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEID-RSGRIVEVNSFLTQDC-L 63 + G +Q++ NRL + + + L G L + D RS V+SF + Sbjct: 20 LTGVCSRTIQHADSQVNRLEITSDKKY-LAAAGHLHVRLYDIRSNNPNPVSSFEGHKGNV 78 Query: 64 FDLAWNESHENQVLVAQG-DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 122 +A+ + EN+ +V+ DGT++++D + + +H V + N+ +S Sbjct: 79 TSIAFQQ--ENRWMVSSSEDGTIKVWD--VRSPSVQRNYKHNAPVNEVAIH-PNQGELIS 133 Query: 123 SSWDGSIKIWSPLRKQSLMTLTPR---PLE---------------------ITKMVDPLN 158 DG+I+IW Q LTP PL+ + +M + Sbjct: 134 CDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTD 193 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH 218 A L+ T + + + S +NL +CS + A +++I ++N+ + Sbjct: 194 ASTLEP--VTKFKSHTKYITRVLLSADVKNLA-TCSADHTARVWNI-------EDNYQLE 243 Query: 219 SGLEALT-----CDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSS 273 + L+ C F+ Y+V T D+ +R+WD+ ++ I R G + Sbjct: 244 TTLDGHQRWVWDCAFSADSAYLV-TACSDHYVRLWDL------STSEIVRQYGGHHKGAV 296 Query: 274 CI 275 C+ Sbjct: 297 CV 298 >5WYJ-BC nrPDB Length = 817 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 47/99 (47%), Gaps = 13/99 (13%) Query: 225 TCDFNKYRPYV-----VATGGVDNAI-RIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 +C F+ Y Y+ V G+ N + + + +L + TIK+ + + S + I Sbjct: 421 SCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQII 480 Query: 279 P------NAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 +AH I ++ SP+ S I +ASYD TC+IW Sbjct: 481 KVSEYTRHAHEKDINALSVSPNDS-IFATASYDKTCKIW 518 >5OQL-L nrPDB Length = 557 Score = 32.0 bits (71), Expect = 0.47, Method: Compositional matrix adjust. Identities = 14/29 (48%), Positives = 19/29 (65%) Query: 296 SNILMSASYDMTCRIWRDLSNDGAKETYK 324 SN+L+S SYD T R+W + GA T+K Sbjct: 202 SNLLVSGSYDETVRVWDARAPGGAVMTFK 230 Score = 30.8 bits (68), Expect = 0.91, Method: Compositional matrix adjust. Identities = 24/84 (28%), Positives = 34/84 (40%), Gaps = 17/84 (20%) Query: 291 WSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFV-FGAD 349 WSP LMS S D T R+W SND + FT H+++V GA Sbjct: 152 WSPTELTTLMSCSDDKTVRLWDLPSNDPTRL----------------FTGHTDYVRCGAF 195 Query: 350 WSLWGKPGYVASTAWDGNLFVWNG 373 + S ++D + VW+ Sbjct: 196 MPGSANSNLLVSGSYDETVRVWDA 219 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 40/84 (47%), Gaps = 11/84 (13%) Query: 173 NRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYR 232 ++ V+ ++SP + ++SCS + L+D LPS F H+ + + C + Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWD--LPSNDPTRLFTGHT--DYVRC--GAFM 196 Query: 233 P-----YVVATGGVDNAIRIWDIR 251 P ++ +G D +R+WD R Sbjct: 197 PGSANSNLLVSGSYDETVRVWDAR 220 >5YZG-W nrPDB Length = 579 Score = 32.0 bits (71), Expect = 0.48, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 6/72 (8%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFD-TTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 120 C D + + S+ V+ G+G L ++D T K + + FK H++ W+ Sbjct: 512 CQVDFSPDMSY---VISGDGNGKLNIWDWKTTKLY--SRFKAHDKVCIGAVWHPHETSKV 566 Query: 121 LSSSWDGSIKIW 132 ++ WDG IK+W Sbjct: 567 ITCGWDGLIKLW 578 >4AEZ-A nrPDB Length = 401 Score = 31.6 bits (70), Expect = 0.54, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 30/75 (40%), Gaps = 20/75 (26%) Query: 236 VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 295 +A+GG DN ++IWD R SS H A++ V W P Sbjct: 232 LASGGNDNVVQIWDAR--------------------SSIPKFTKTNHNAAVKAVAWCPWQ 271 Query: 296 SNILMSASYDMTCRI 310 SN+L + M +I Sbjct: 272 SNLLATGGGTMDKQI 286 >6F3T-A nrPDB Length = 608 Score = 31.6 bits (70), Expect = 0.55, Method: Compositional matrix adjust. Identities = 48/218 (22%), Positives = 81/218 (37%), Gaps = 60/218 (27%) Query: 97 IAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDP 156 + I H V+ +++ +R LSSS DG++++WS L T T Sbjct: 344 LKILYGHSGPVYGASFS-PDRNYLLSSSEDGTVRLWS------LQTFT------------ 384 Query: 157 LNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFL 216 G + V+ QFSP+ V G+ + RL + + Sbjct: 385 ---------CLVGYKGHNYPVWDTQFSPYGYYFV--SGGHDRVA----RLWATDHYQPLR 429 Query: 217 VHSG-LEALTCDFNKYRPY--VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSS 273 + +G L + C ++ P VATG D +R+WD+ N + Sbjct: 430 IFAGHLADVNC--TRFHPNSNYVATGSADRTVRLWDVL-------------------NGN 468 Query: 274 CINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 C+ I H I +T+SP + L + + D +W Sbjct: 469 CV-RIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLW 504 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 20/91 (21%), Positives = 41/91 (45%), Gaps = 18/91 (19%) Query: 235 VVATGGVDNAIRIW--------------DIRMLNKNESATIKRTVPGQLHNSSCINEIPN 280 ++A G D+ +R+W D+ +++K ++R + ++ +I Sbjct: 292 LIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMD---EKTASELKILY 348 Query: 281 AHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 H + ++SP N L+S+S D T R+W Sbjct: 349 GHSGPVYGASFSPDR-NYLLSSSEDGTVRLW 378 >6QDV-o nrPDB Length = 513 Score = 31.6 bits (70), Expect = 0.58, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 6/72 (8%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFD-TTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 120 C D + + S+ V+ G+G L ++D T K + + FK H++ W+ Sbjct: 446 CQVDFSPDMSY---VISGDGNGKLNIWDWKTTKLY--SRFKAHDKVCIGAVWHPHETSKV 500 Query: 121 LSSSWDGSIKIW 132 ++ WDG IK+W Sbjct: 501 ITCGWDGLIKLW 512 >6MZM-G nrPDB Length = 800 Score = 31.6 bits (70), Expect = 0.64, Method: Compositional matrix adjust. Identities = 50/216 (23%), Positives = 81/216 (37%), Gaps = 60/216 (27%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 I H V+ +++ +R LSSS DG++++WS L T T Sbjct: 538 ILYGHSGPVYGASFS-PDRNYLLSSSEDGTVRLWS------LQTFT-------------- 576 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH 218 G + V+ QFSP+ V G+ + RL + + + Sbjct: 577 -------CLVGYKGHNYPVWDTQFSPYGYYFV--SGGHDRVA----RLWATDHYQPLRIF 623 Query: 219 SG-LEALTCDFNKYRPY--VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 +G L + C ++ P VATG D +R+WD+ LN N C+ Sbjct: 624 AGHLADVNC--TRFHPNSNYVATGSADRTVRLWDV--LNGN-----------------CV 662 Query: 276 NEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 I H I +T+SP + L + + D +W Sbjct: 663 R-IFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLW 696 >3JB9-L nrPDB Length = 340 Score = 31.2 bits (69), Expect = 0.67, Method: Compositional matrix adjust. Identities = 36/142 (25%), Positives = 58/142 (40%), Gaps = 35/142 (24%) Query: 236 VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 295 V GG+D AI+IWD+R N+ C + + H I + S Sbjct: 192 VFIGGIDGAIKIWDLR-------------------NNHC-SHVLKGHKDIITSLAISKDG 231 Query: 296 SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEF--VFGADWSLW 353 S+ L+S S D T RI+ K ++ + IF H + + G WS Sbjct: 232 SS-LLSNSMDNTVRIF----------DVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRN 280 Query: 354 GKPGYVASTAWDGNLFVWNGLG 375 + +V + + D N++VW+ G Sbjct: 281 SR--FVGAGSSDKNVYVWSATG 300 >6F1U-h nrPDB Length = 612 Score = 31.2 bits (69), Expect = 0.67, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 33/80 (41%), Gaps = 8/80 (10%) Query: 210 KNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRT---VP 266 K ++ H ++ F K+ P +V G I +WD R N+ ++RT Sbjct: 296 KTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNR---SNKRTPVQRTPLSAA 352 Query: 267 GQLHNSSCINEI--PNAHGL 284 H C+N + NAH L Sbjct: 353 AHTHPVYCVNVVGTQNAHNL 372 >5XYI-g nrPDB Length = 335 Score = 30.8 bits (68), Expect = 0.90, Method: Compositional matrix adjust. Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 33/142 (23%) Query: 116 NRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRN 175 + + L+SSWD ++++W L T T KK F G K+ Sbjct: 91 DASHLLTSSWDSTLRLW------DLSTRT------------------TKKLFLGHKKD-- 124 Query: 176 CVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCD--FNKYRP 233 V FSP ++ ++S ++ +++I G+N+ S + ++ C ++ P Sbjct: 125 -VLGVTFSPCNRR-IISVGRDNQVKIWNIL---GENKAELQCSSWVTSVACAPMADETSP 179 Query: 234 YVVATGGVDNAIRIWDIRMLNK 255 V+A G D + IW I K Sbjct: 180 LVIAVGCWDGKVYIWSIEKEAK 201 >5L9T-R nrPDB Length = 493 Score = 30.8 bits (68), Expect = 0.97, Method: Compositional matrix adjust. Identities = 20/83 (24%), Positives = 34/83 (40%), Gaps = 22/83 (26%) Query: 235 VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 ++A+GG DN + +W+ H+S + H A++ + WSPH Sbjct: 327 LLASGGNDNKLLVWN--------------------HSSLSPVQQYTEHLAAVKAIAWSPH 366 Query: 295 HSNILMS--ASYDMTCRIWRDLS 315 +L S + D R W L+ Sbjct: 367 QHGLLASGGGTADRCIRFWNTLT 389 >6HQA-B nrPDB Length = 722 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 60/265 (22%), Positives = 96/265 (36%), Gaps = 64/265 (24%) Query: 6 MQGFSG--YGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCL 63 + G SG YGV +SP DNR ++ + + V + S T CL Sbjct: 449 LVGHSGAVYGVDFSP--DNRYLISCSED------------------KTVRLWSLDTYTCL 488 Query: 64 FDLAWNESHENQV---------LVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNL 114 + S V A D T RL+ +P+ IF H +V C Sbjct: 489 VSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHI-YPLRIFAGHLNDV-DCVEFH 546 Query: 115 VNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNR 174 N + S D + ++W R + + + F G S Sbjct: 547 PNSTYLFTGSSDKTARMWDIARGECV------------------------RVFMGHSGAI 582 Query: 175 NCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPY 234 NC+ SP D + S +S L+DI +G+ H + F++ Sbjct: 583 NCL---AVSP-DGRWLASAGEDSVVCLWDIS--TGRRIKAMRGHGRSSIYSLAFSREGTV 636 Query: 235 VVATGGVDNAIRIWDIRMLNKNESA 259 +V+TG DN++R+WD++ + SA Sbjct: 637 LVSTGA-DNSVRVWDVKKNTNSPSA 660 >2PM9-A nrPDB Length = 416 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 18/85 (21%), Positives = 38/85 (44%), Gaps = 4/85 (4%) Query: 66 LAWNESHENQVLVAQG---DGTLRLFDTTFKEFPIAIFKE-HEREVFSCNWNLVNRQNFL 121 + W+ + +V A G D ++ ++D P+ + H++ + S +W + L Sbjct: 220 VEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLL 279 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPR 146 SS D ++ +W+P + L R Sbjct: 280 SSGRDNTVLLWNPESAEQLSQFPAR 304 Score = 28.5 bits (62), Expect = 4.8, Method: Compositional matrix adjust. Identities = 58/258 (22%), Positives = 102/258 (39%), Gaps = 50/258 (19%) Query: 65 DLAWNESHENQVLVAQGD-GTLRLFDTTFKEFPI---AIFKEHEREVFSCNWNLVNRQNF 120 DL W SH N+++ D G+L L+ T I A F H V + +N Sbjct: 72 DLDW--SHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVL 129 Query: 121 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA 180 S +G I IW + K + PL + + ++ +I ++ N++ + Sbjct: 130 ASGGNNGEIFIWD-MNKCTESPSNYTPLTPGQSMSSVDEVI-------SLAWNQSLAH-- 179 Query: 181 QFSPHDQNLVLSCSGNS-YASLFDIRLPSGKNQNNFLV-HSGLEAL--TCDFNKYRPYVV 236 V + +G+S +AS++D++ ++ +SG++ +++ V Sbjct: 180 ---------VFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRV 230 Query: 237 ATG-GVDN--AIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP 293 AT G DN +I IWD+R N P Q N H I + W Sbjct: 231 ATATGSDNDPSILIWDLRNAN----------TPLQTLN--------QGHQKGILSLDWCH 272 Query: 294 HHSNILMSASYDMTCRIW 311 ++L+S+ D T +W Sbjct: 273 QDEHLLLSSGRDNTVLLW 290 >3JB9-g nrPDB Length = 558 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 38/174 (21%), Positives = 72/174 (41%), Gaps = 31/174 (17%) Query: 76 VLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPL 135 +L D +++++ + F+ H R + +++ R +FLS+S+D +IK+W Sbjct: 282 LLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGR-SFLSTSFDKTIKLWD-- 338 Query: 136 RKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSG 195 E+ K ++ N+ L NCV + Q P N L+ + Sbjct: 339 ------------TELGKCLNCFNSDRLT-----------NCV-KFQVDPDKPNEFLAGTA 374 Query: 196 NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWD 249 + FDIR P + + G+ ++T N R T D+++R W+ Sbjct: 375 DKRILQFDIRSPDIVQAYDHHL-GGINSITFLENGKR---FVTTSDDSSMRFWE 424 Score = 28.1 bits (61), Expect = 5.9, Method: Compositional matrix adjust. Identities = 17/78 (21%), Positives = 34/78 (43%), Gaps = 20/78 (25%) Query: 234 YVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP 293 +++ +G +DN I+IW++ H+ S + H IR +++S Sbjct: 280 HLLLSGSMDNQIKIWEV------------------YHDRSLLRTF-QGHARPIRDLSFS- 319 Query: 294 HHSNILMSASYDMTCRIW 311 +S S+D T ++W Sbjct: 320 QDGRSFLSTSFDKTIKLW 337 >5OPT-p nrPDB Length = 318 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 32/137 (23%), Positives = 62/137 (45%), Gaps = 29/137 (21%) Query: 206 LPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTV 265 L +G Q+ FL H+ + L+ F+ +V +GG DNA+R+W+++ Sbjct: 96 LQTGVCQHKFLGHTK-DVLSVTFSPDNRQIV-SGGRDNALRVWNVK-------------- 139 Query: 266 PGQLHNSSCINEIP-NAHGLAIRKVTWSPH-HSNILMSASYDMTCRIW-----RDLSNDG 318 C++ + AH + V +SP + +++S +D ++W R L++ Sbjct: 140 ------GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLK 193 Query: 319 AKETYKTNSTDATKGSI 335 Y T+ T + GS+ Sbjct: 194 GHTNYITSVTVSPDGSL 210 >4J0W-A nrPDB Length = 343 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 31/112 (27%), Positives = 54/112 (48%), Gaps = 12/112 (10%) Query: 36 GNGKLFILEIDRSGRI--VEVNSFLT-----QDCLFDLAWNESHENQVLVAQGDGTLRLF 88 G +L+ DRS ++ V NS++ QD + L S E V DGT+R++ Sbjct: 120 GTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALD-ALSRECCVTAGGRDGTVRVW 178 Query: 89 DTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSL 140 E +F H+ + C +L+N ++ +S + DGS+ +W +K+ L Sbjct: 179 --KIPEESQLVFYGHQGSI-DCI-HLINEEHMVSGADDGSVALWGLSKKRPL 226 >1PI6-A nrPDB Length = 615 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 13/85 (15%) Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK-----NQNNFLVHSGLEALT- 225 K + V +FSP V++ + S FD + SG+ + V G+ AL+ Sbjct: 204 KQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK--SGEFLKYIEDDQEPVQGGIFALSW 261 Query: 226 CDFNKYRPYVVATGGVDNAIRIWDI 250 D K+ AT G D IR+WD+ Sbjct: 262 LDSQKF-----ATVGADATIRVWDV 281 >6J6H-n nrPDB Length = 455 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 46/114 (40%), Gaps = 23/114 (20%) Query: 234 YVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP 293 +++ +GG D+ I+IWD H+ C+ + H I+ + ++ Sbjct: 176 HLILSGGNDHTIKIWDF------------------YHDYECLRDF-QGHNKPIKALRFT- 215 Query: 294 HHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFG 347 +S+S+D + +IW D K NST A S T EF+ G Sbjct: 216 EDCQSFLSSSFDRSVKIW-DTETGKVKTRLHLNSTPADVES--RPTNPHEFIVG 266 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 32/57 (56%), Gaps = 1/57 (1%) Query: 76 VLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIW 132 +L D T++++D + F+ H + + + + + Q+FLSSS+D S+KIW Sbjct: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT-EDCQSFLSSSFDRSVKIW 233 >6BX3-A nrPDB Length = 314 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 4/75 (5%) Query: 100 FKEHEREVFSCNWNLVNRQNFL-SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 F H V S +N + N L +SS D SIKIW L + T++ + + P+N Sbjct: 91 FIGHTAPVISLTFN--RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN 148 Query: 159 -AIILKKKSFTGISK 172 + IL S+ G+ + Sbjct: 149 DSSILSSGSYDGLIR 163 >6CHG-A nrPDB Length = 312 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 35/144 (24%), Positives = 58/144 (40%), Gaps = 9/144 (6%) Query: 29 GSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLF 88 G + N + + EI S + + ++C+ L W+ + +A G + Sbjct: 25 GELIAICQNTDMLVYEISSSKMMKLTTTH--KECINCLCWSPDSK---CIASGSEDFTVE 79 Query: 89 DTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL-SSSWDGSIKIWSPLRKQSLMTLTPRP 147 T I H V S +N N+ N L SSS D SIK W L +L T++ Sbjct: 80 ITHIIYGRIRRLMGHTAPVISICYN--NKGNILCSSSMDESIKEWHVLSGTALKTMSAHS 137 Query: 148 LEITKMVDP-LNAIILKKKSFTGI 170 + + P ++ IL S+ G+ Sbjct: 138 DAVVSIDIPKFDSSILSSGSYDGL 161 >6ID0-T nrPDB Length = 514 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 37/155 (23%), Positives = 63/155 (40%), Gaps = 34/155 (21%) Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKS----FTGISKN 173 Q F++ S D +IKIW L L L +T + + +I+ +S G K Sbjct: 217 QWFVTGSADRTIKIWD-LASGKLK------LSLTGHISTVRGVIVSTRSPYLFSCGEDKQ 269 Query: 174 RNC------------------VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 215 C VY P +++++CS +S A ++D+R + + + Sbjct: 270 VKCWDLEYNKVIRHYHGHLSAVYGLDLHP-TIDVLVTCSRDSTARIWDVR--TKASVHTL 326 Query: 216 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI 250 H+ A T P ++ TG D IR+WD+ Sbjct: 327 SGHTNAVA-TVRCQAAEPQII-TGSHDTTIRLWDL 359 >4V8M-A7 nrPDB Length = 318 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 29/46 (63%), Gaps = 2/46 (4%) Query: 206 LPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 251 L +G+ Q FL H+ + L+ F+ +V +GG DNA+R+W+++ Sbjct: 96 LQNGQCQYKFLGHTK-DVLSVAFSPDNRQIV-SGGRDNALRVWNVK 139 >4OM9-A nrPDB Length = 966 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 53/129 (41%), Gaps = 26/129 (20%) Query: 8 GFSGYGVQYSPFFDNRLA--VAAGSNFGLVGNGK-------------------LFI--LE 44 G SG GV FDN+ V G+ G++GNGK LFI + Sbjct: 206 GDSGSGVY---VFDNKEDKWVLLGTTHGIIGNGKTQKTYVTPFDSKTTNELKQLFIQNVN 262 Query: 45 IDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHE 104 ID + + + D+ N++++N+ LV G G + L + + IF E++ Sbjct: 263 IDNNTATIGGGKITIGNTTQDIEKNKNNQNKDLVFSGGGKISLKENLDLGYGGFIFDENK 322 Query: 105 REVFSCNWN 113 + S N Sbjct: 323 KYTVSAEGN 331 >5OVO-B nrPDB Length = 99 Score = 29.3 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 20/27 (74%) Query: 25 AVAAGSNFGLVGNGKLFILEIDRSGRI 51 A+ +N G +G+GK+F+L+I ++ RI Sbjct: 63 AIQKAANTGRIGDGKIFVLDIAQAVRI 89 >4CO4-A nrPDB Length = 112 Score = 29.3 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 20/27 (74%) Query: 25 AVAAGSNFGLVGNGKLFILEIDRSGRI 51 A+ +N G +G+GK+F+L+I ++ RI Sbjct: 76 AIQKAANTGRIGDGKIFVLDIAQAVRI 102 >6HHQ-h nrPDB Length = 319 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 39/211 (18%), Positives = 80/211 (37%), Gaps = 34/211 (16%) Query: 66 LAWNESHENQVLVAQGDGTLRLFDTTFKE----FPIAIFKEHEREVFSCNWNLVNRQNFL 121 LA + N +L A D TL + T + P+ FK H V C + L Sbjct: 23 LATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLT-ADGAYAL 81 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM-VDPLNAII-------------LKKKSF 167 S+SWD ++++W ++ ++ + +D ++I +K + Sbjct: 82 SASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCL 141 Query: 168 TGISKNRNCVYQAQFSPH----DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA 223 + + + V Q + P+ D ++ + +GN ++ N N F + + Sbjct: 142 ATLLGHNDWVSQVRVVPNEKADDDSVTIISAGND-------KMVKAWNLNQFQIEADFIG 194 Query: 224 LTCDFNKYRP----YVVATGGVDNAIRIWDI 250 + N ++A+ G D I +W++ Sbjct: 195 HNSNINTLTASPDGTLIASAGKDGEIMLWNL 225 Score = 28.5 bits (62), Expect = 4.4, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 33/81 (40%), Gaps = 13/81 (16%) Query: 292 SPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 351 S N+L+SAS D T W+ L+ D K S F HS V D + Sbjct: 26 SAGQPNLLLSASRDKTLISWK-LTGDDQKFGVPVRS----------FKGHSHIV--QDCT 72 Query: 352 LWGKPGYVASTAWDGNLFVWN 372 L Y S +WD L +W+ Sbjct: 73 LTADGAYALSASWDKTLRLWD 93 >5WLC-LW nrPDB Length = 554 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 234 YVVATGGVDNAIRIWDIR 251 Y +AT G D +++IWDIR Sbjct: 287 YYMATTGADRSMKIWDIR 304 >5WLC-LJ nrPDB Length = 513 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 20/84 (23%), Positives = 38/84 (45%), Gaps = 4/84 (4%) Query: 169 GISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEAL-TCD 227 I+ + + + +F D ++ + S + L+DI S + + + + T Sbjct: 119 SINASTHPTHVTKFHTQDNKILATASDDRVTRLWDI---SNAYEPQLELTGATDYVRTLS 175 Query: 228 FNKYRPYVVATGGVDNAIRIWDIR 251 F P++VATG D IR++D R Sbjct: 176 FIPAAPHLVATGSYDGLIRLYDTR 199 >5BJS-A nrPDB Length = 605 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 17/31 (54%) Query: 281 AHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 HG I + SP + I+ SAS D T RIW Sbjct: 176 GHGGGINDLATSPANPYIIASASDDTTIRIW 206 >1C7Z-A nrPDB Length = 191 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 27/115 (23%), Positives = 50/115 (43%), Gaps = 11/115 (9%) Query: 119 NFLSSSWDGSIKIWSPLRKQSLMTLTPR--PLEITKMVDPLNAIILKKKSFTGISKNRNC 176 NF+ S S+K+W+ K+++ T P E K ++ ++A + ++ ++ I ++ Sbjct: 39 NFIRSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEH--- 95 Query: 177 VYQAQFSPHDQN--LVLSCSGNSYASLFDIRLP---SGKNQNNFLVHSGLEALTC 226 Y +F+ DQ+ G SY L P + Q N LV + C Sbjct: 96 -YPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRC 149 >6ELZ-p nrPDB Length = 460 Score = 28.5 bits (62), Expect = 5.4, Method: Compositional matrix adjust. Identities = 38/174 (21%), Positives = 68/174 (39%), Gaps = 42/174 (24%) Query: 82 DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLM 141 DGT+R + P+++ + H V ++ + S S D +IK W + + + Sbjct: 271 DGTIR------RRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCID 324 Query: 142 TLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASL 201 T T S++ +S AQ S NL+ S + +L Sbjct: 325 TRT--------------------TSYSLLS-------IAQLST--LNLLACGSSARHITL 355 Query: 202 FDIRL--PSGKNQNNFLVHSGLEAL--TCDFNKYRPYVVATGGVDNAIRIWDIR 251 D R+ S Q + H + TC N+Y ++ +G D +++WD+R Sbjct: 356 HDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEY---ILCSGSHDGTVKVWDVR 406 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 21/64 (32%), Positives = 32/64 (50%), Gaps = 14/64 (21%) Query: 97 IAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDP 156 +AI + H+ V S + + + LS+S+D SI WS + K+ MT +VDP Sbjct: 201 LAILEGHKAPVVSID--VSDNSRILSASYDNSIGFWSTIYKE--MT----------VVDP 246 Query: 157 LNAI 160 L I Sbjct: 247 LEDI 250 >4U1E-I nrPDB Length = 347 Score = 28.1 bits (61), Expect = 5.7, Method: Compositional matrix adjust. Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 6/79 (7%) Query: 188 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 247 +L+ SCS +S AS++ +G+ H+G + D + + Y V TG D +I++ Sbjct: 23 DLLFSCSKDSSASVW--YSLNGERLGTLDGHTGT-IWSIDVDCFTKYCV-TGSADYSIKL 78 Query: 248 WDIRMLNKNESATIKRTVP 266 WD+ N AT K VP Sbjct: 79 WDVS--NGQCVATWKSPVP 95 >3I2N-A nrPDB Length = 357 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 39/188 (20%), Positives = 77/188 (40%), Gaps = 34/188 (18%) Query: 74 NQVLVAQGD--GTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQ------NFLSSSW 125 Q +A GD G L +++ E P+ K H +E+ + + ++ S Sbjct: 79 QQRYLATGDFGGNLHIWNLEAPEMPVYSVKGH-KEIINAIDGIGGLGIGEGAPEIVTGSR 137 Query: 126 DGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPH 185 DG++K+W P +K DP + + G +K R+C A + + Sbjct: 138 DGTVKVWDPRQKD----------------DP----VANMEPVQGENK-RDCWTVAFGNAY 176 Query: 186 DQNLVLSCSG--NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDN 243 +Q + C+G N LFD+R + + + N + +G+ +L D + ++ Sbjct: 177 NQEERVVCAGYDNGDIKLFDLRNMALRWETN--IKNGVCSLEFDRKDISMNKLVATSLEG 234 Query: 244 AIRIWDIR 251 ++D+R Sbjct: 235 KFHVFDMR 242 >3NCV-A nrPDB Length = 220 Score = 28.1 bits (61), Expect = 7.0, Method: Compositional matrix adjust. Identities = 21/74 (28%), Positives = 33/74 (44%), Gaps = 11/74 (14%) Query: 5 HMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLF 64 H + +G+G++ S N LAV A ++G + L D G + +V S T Sbjct: 100 HAETLAGFGLELSDMGGNTLAVRAAPV--MLGKSDVVSLARDVLGELAQVGSSQT----- 152 Query: 65 DLAWNESHENQVLV 78 SHEN++L Sbjct: 153 ----IASHENRILA 162 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3W15-A nrPDB 521 e-148 5WJC-A nrPDB 280 6e-76 3C9C-A nrPDB 269 2e-72 5Y1U-A nrPDB 267 4e-72 4XYI-A nrPDB 267 5e-72 3CFV-B nrPDB 265 2e-71 5OQL-d nrPDB 230 8e-61 5MZH-A nrPDB 221 3e-58 6QX9-5O nrPDB 177 7e-45 5M25-A nrPDB 150 8e-37 2H9P-A nrPDB 148 3e-36 6EMK-B nrPDB 137 7e-33 6Q8F-A nrPDB 130 8e-31 6QX9-4B nrPDB 126 1e-29 5FL8-q nrPDB 125 2e-29 4A11-B nrPDB 99 3e-21 Sequences not found previously or not previously below threshold: 5NNZ-B nrPDB 172 2e-43 4PSX-B nrPDB 140 1e-33 5WLC-LU nrPDB 125 4e-29 5FVM-C nrPDB 118 3e-27 6F3T-A nrPDB 111 5e-25 6MZM-G nrPDB 110 1e-24 6HQA-B nrPDB 108 4e-24 3FM0-A nrPDB 104 5e-23 1VYH-C nrPDB 102 2e-22 5Z56-q nrPDB 99 1e-21 4LG8-A nrPDB 97 1e-20 3JB9-L nrPDB 95 6e-20 5UZ7-B nrPDB 94 1e-19 4V7E-Bg nrPDB 93 1e-19 6EOJ-D nrPDB 93 2e-19 3DM0-A nrPDB 93 2e-19 3JRO-A nrPDB 93 2e-19 4YCZ-A nrPDB 91 7e-19 5NZU-C nrPDB 90 1e-18 6ID0-T nrPDB 90 1e-18 5GAN-H nrPDB 88 5e-18 6N9G-C nrPDB 88 5e-18 2HES-X nrPDB 88 6e-18 3JRP-A nrPDB 87 1e-17 4V6W-Ag nrPDB 87 2e-17 6G51-g nrPDB 86 3e-17 3MKQ-A nrPDB 85 4e-17 4BZK-B nrPDB 85 4e-17 4V8M-A7 nrPDB 84 8e-17 2YNP-A nrPDB 84 1e-16 5WLC-LO nrPDB 83 2e-16 5CXC-A nrPDB 83 2e-16 5OPT-p nrPDB 82 3e-16 5FA5-B nrPDB 82 4e-16 5I2T-A nrPDB 81 6e-16 5YZG-W nrPDB 81 9e-16 4L9O-A nrPDB 81 1e-15 6QDV-o nrPDB 81 1e-15 2AQ5-A nrPDB 80 2e-15 5OQL-J nrPDB 79 3e-15 6HHQ-h nrPDB 79 4e-15 5WBU-D nrPDB 77 1e-14 3I2N-A nrPDB 76 2e-14 3JB9-g nrPDB 76 2e-14 5A9Q-7 nrPDB 76 2e-14 2PM9-A nrPDB 76 3e-14 6J6H-n nrPDB 75 3e-14 5K1B-B nrPDB 75 4e-14 6GMH-W nrPDB 75 4e-14 6BX3-A nrPDB 75 5e-14 5Y88-O nrPDB 75 5e-14 3JAP-g nrPDB 73 2e-13 3BG0-A nrPDB 73 2e-13 6ELZ-p nrPDB 73 3e-13 5WYJ-BC nrPDB 72 3e-13 5OQL-L nrPDB 71 1e-12 4G56-B nrPDB 71 1e-12 5G04-R nrPDB 70 1e-12 4GGA-A nrPDB 69 3e-12 5WYK-BB nrPDB 69 3e-12 5LCW-Q nrPDB 69 3e-12 4OWR-A nrPDB 69 3e-12 4XFV-A nrPDB 69 4e-12 4BTS-AR nrPDB 67 1e-11 4N14-A nrPDB 67 2e-11 5XYI-g nrPDB 66 2e-11 5WLC-LJ nrPDB 66 2e-11 5L9T-R nrPDB 66 3e-11 6CHG-A nrPDB 65 5e-11 4E5Z-B nrPDB 65 5e-11 1NR0-A nrPDB 65 8e-11 3ODT-A nrPDB 63 2e-10 4AEZ-A nrPDB 63 2e-10 3EI3-B nrPDB 62 5e-10 6F1U-h nrPDB 62 5e-10 4BH6-A nrPDB 60 1e-09 3JZG-A nrPDB 60 2e-09 4U1E-I nrPDB 60 2e-09 5A9Q-0 nrPDB 58 6e-09 3F3P-A nrPDB 58 7e-09 5OQL-X nrPDB 58 9e-09 5MWJ-A nrPDB 56 2e-08 5BJS-A nrPDB 56 3e-08 5N4A-A nrPDB 55 7e-08 3ACP-A nrPDB 55 7e-08 5OV3-A nrPDB 53 2e-07 5A31-R nrPDB 53 2e-07 3DW8-B nrPDB 52 4e-07 4J0W-A nrPDB 52 4e-07 5K0Y-T nrPDB 51 9e-07 1PI6-A nrPDB 50 3e-06 5TF2-A nrPDB 49 3e-06 5WYJ-BE nrPDB 49 3e-06 5K19-A nrPDB 49 4e-06 6CB1-s nrPDB 49 4e-06 6C0F-s nrPDB 49 4e-06 6EM1-m nrPDB 49 4e-06 2I3T-A nrPDB 48 5e-06 6E29-D nrPDB 48 9e-06 5A9Q-2 nrPDB 46 3e-05 6BX3-B nrPDB 46 4e-05 3JB9-S nrPDB 44 1e-04 5WLC-LN nrPDB 43 2e-04 5WLC-LW nrPDB 40 0.002 5WLC-SG nrPDB 40 0.003 4J0X-A nrPDB 40 0.003 5MC6-j nrPDB 39 0.004 5CXB-B nrPDB 39 0.004 4FHN-A nrPDB 38 0.006 5YZG-2 nrPDB 37 0.015 6CHG-D nrPDB 37 0.016 6N8P-A nrPDB 36 0.022 6AJD-A nrPDB 35 0.079 6CVZ-A nrPDB 34 0.12 5AMS-A nrPDB 32 0.45 2P9P-C nrPDB 31 0.75 5WLC-LH nrPDB 31 1.1 3C75-L nrPDB 31 1.1 4V0N-B nrPDB 31 1.2 2VR2-A nrPDB 30 1.3 5OVO-B nrPDB 30 1.4 4CO4-A nrPDB 30 1.4 4PDX-A nrPDB 28 7.4 5JVV-B nrPDB 28 7.5 >3W15-A nrPDB Length = 368 Score = 521 bits (1341), Expect = e-148, Method: Composition-based stats. Identities = 366/375 (97%), Positives = 366/375 (97%), Gaps = 9/375 (2%) Query: 1 MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQ 60 MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQ Sbjct: 3 MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQ 62 Query: 61 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 120 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNF Sbjct: 63 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 122 Query: 121 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA 180 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA Sbjct: 123 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA 182 Query: 181 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG 240 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG Sbjct: 183 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG 242 Query: 241 VDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM 300 VDNAIRIWDIRMLNKN PGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM Sbjct: 243 VDNAIRIWDIRMLNKN---------PGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM 293 Query: 301 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA 360 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA Sbjct: 294 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA 353 Query: 361 STAWDGNLFVWNGLG 375 STAWDGNLFVWNGLG Sbjct: 354 STAWDGNLFVWNGLG 368 >5WJC-A nrPDB Length = 430 Score = 280 bits (716), Expect = 6e-76, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 126/329 (38%), Gaps = 47/329 (14%) Query: 52 VEVNSFLTQDCLFDLAWNESHENQVLVAQGDG-TLRLFDTTFKEF-------PIAIFKEH 103 +E++ + D + A + +++ G+G +FDTT + P A+ K H Sbjct: 122 IEISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGH 181 Query: 104 EREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILK 163 E F WN N + + D I +W ++ QS + TK++ P I K Sbjct: 182 TAEGFGLCWNPNLPGNLATGAEDQVICLWD-VQTQSFTSSE------TKVISP----IAK 230 Query: 164 KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA 223 T I V QF P + L+ S S + + D RL + + Sbjct: 231 YHRHTDI------VNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAI 284 Query: 224 LTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHG 283 N + Y++AT D + +WD+R + +LH H Sbjct: 285 NAVAINPFNDYLLATASADKTVALWDLRNPYQ------------RLHTLE-------GHE 325 Query: 284 LAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSE 343 + + WSPH IL S+S D IW DL G ++T + ++ D + +F H+ Sbjct: 326 DEVYGLEWSPHDEPILASSSTDRRVCIW-DLEKIGEEQTPE-DAEDGSPELLFMHGGHTN 383 Query: 344 FVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + W + V S A D L +W+ Sbjct: 384 RISEFSWCP-NERWVVGSLADDNILQIWS 411 Score = 51.8 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 42/106 (39%), Gaps = 16/106 (15%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDT-------TFKEFPIAIFK------EHERE 106 +D ++ L W+ E + + D + ++D T ++ + H Sbjct: 325 EDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNR 384 Query: 107 VFSCNWNLVNRQNFLSSSWDGSIKIWSPLR---KQSLMTLTPRPLE 149 + +W R S + D ++IWSP R + + ++PR LE Sbjct: 385 ISEFSWCPNERWVVGSLADDNILQIWSPSRVIWGRDHVQVSPRDLE 430 >3C9C-A nrPDB Length = 432 Score = 269 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 66/330 (20%), Positives = 123/330 (37%), Gaps = 52/330 (15%) Query: 52 VEVNSFLTQDCLFDLAWNESHENQVLVA-QGDGTLRLFDTTFKE---------FPIAIFK 101 +E+ + + + A V+ + +FD T P + Sbjct: 121 IEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR 180 Query: 102 EHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAII 161 H++E + +WN LS+S D +I +W + +I Sbjct: 181 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATP-----------------KEHRVI 223 Query: 162 LKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGL 221 K FTG + V + ++L S + + ++D R + ++ + Sbjct: 224 DAKNIFTGHT---AVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTA 280 Query: 222 EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNA 281 E FN Y +++ATG D + +WD+R L +LH+ + Sbjct: 281 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKL------------KLHSFE-------S 321 Query: 282 HGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQH 341 H I +V WSPH+ IL S+ D +W DLS G +++ + ++ D +F H Sbjct: 322 HKDEIFQVQWSPHNETILASSGTDRRLHVW-DLSKIGEEQSTE-DAEDGPPELLFIHGGH 379 Query: 342 SEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 + + W+ +P + S + D + VW Sbjct: 380 TAKISDFSWNP-NEPWIICSVSEDNIMQVW 408 Score = 74.2 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 34/207 (16%), Positives = 76/207 (36%), Gaps = 34/207 (16%) Query: 173 NRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRL------PSGKNQNNFLVH-SGLEALT 225 + V +A++ P + ++ + + +S +FD PSG+ Q + + E Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 226 CDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLA 285 +N + + D+ I +WDI + H I H Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDI-------------NATPKEHRVIDAKNIFTGHTAV 235 Query: 286 IRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFV 345 + V W H ++ S + D IW +N+ +K ++ ++ H+ V Sbjct: 236 VEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDA-------------HTAEV 282 Query: 346 FGADWSLWGKPGYVASTAWDGNLFVWN 372 ++ + + +A+ + D + +W+ Sbjct: 283 NCLSFNPYSE-FILATGSADKTVALWD 308 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 26/160 (16%), Positives = 58/160 (36%), Gaps = 13/160 (8%) Query: 66 LAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSW 125 L++N E + D T+ L+D + + F+ H+ E+F W+ N SS Sbjct: 285 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 344 Query: 126 DGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPH 185 D + +W L + P + + + + ++P+ Sbjct: 345 DRRLHVWD------LSKIGEEQSTEDAEDGPPELLFIH-------GGHTAKISDFSWNPN 391 Query: 186 DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALT 225 + ++ S S ++ ++ + ++ + S LE T Sbjct: 392 EPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNT 431 >5Y1U-A nrPDB Length = 456 Score = 267 bits (683), Expect = 4e-72, Method: Composition-based stats. Identities = 67/334 (20%), Positives = 126/334 (37%), Gaps = 53/334 (15%) Query: 48 SGRIVEVNSFLTQDCLFDLAWNESHENQVLVA-QGDGTLRLFDTTFKE---------FPI 97 SG+I E+ + + + A ++ + +FD T P Sbjct: 143 SGKI-EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPD 201 Query: 98 AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPL 157 + H++E + +WN + LS+S D +I +W Sbjct: 202 LRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVP-----------------KE 244 Query: 158 NAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLV 217 ++ K FTG + V + ++L S + + ++D R + ++ + Sbjct: 245 GKVVDAKTIFTGHT---AVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD 301 Query: 218 HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINE 277 E FN Y +++ATG D + +WD+R L +LH+ Sbjct: 302 AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL------------KLHSFE---- 345 Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFN 337 +H I +V WSPH+ IL S+ D +W DLS G +++ + ++ D +F Sbjct: 346 ---SHKDEIFQVQWSPHNETILASSGTDRRLNVW-DLSKIGEEQSPE-DAEDGPPELLFI 400 Query: 338 FTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 H+ + W+ +P + S + D + VW Sbjct: 401 HGGHTAKISDFSWNP-NEPWVICSVSEDNIMQVW 433 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 34/207 (16%), Positives = 77/207 (37%), Gaps = 34/207 (16%) Query: 173 NRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRL------PSGKNQNNFLVH-SGLEALT 225 + V +A++ P + ++ + + +S +FD PSG+ + + E Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 226 CDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLA 285 +N + + D+ I +WDI + K + I H Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAK-------------TIFTGHTAV 260 Query: 286 IRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFV 345 + V+W H ++ S + D IW SN+ +K ++ ++ H+ V Sbjct: 261 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA-------------HTAEV 307 Query: 346 FGADWSLWGKPGYVASTAWDGNLFVWN 372 ++ + + +A+ + D + +W+ Sbjct: 308 NCLSFNPYSE-FILATGSADKTVALWD 333 >4XYI-A nrPDB Length = 430 Score = 267 bits (682), Expect = 5e-72, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 129/329 (39%), Gaps = 47/329 (14%) Query: 52 VEVNSFLTQDCLFDLAWNESHENQVLVAQG-DGTLRLFDTT-FKEFPI------AIFKEH 103 +++ + + + A ++ G +G +FD ++E PI A + H Sbjct: 122 LDIVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHH 181 Query: 104 EREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILK 163 E F WN + + + D SI +W + + L + K +D + Sbjct: 182 TSEGFGLGWNFIQEGTLATGTEDTSICVWD---------IKGKSLSLEKSIDVAPVSVYH 232 Query: 164 KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA 223 + + V QF + L+ S S + + D RLPS + + + Sbjct: 233 R--------HTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPV 284 Query: 224 LTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHG 283 FN + Y++AT D+ + +WD+R LN+ +LH H Sbjct: 285 NGVAFNPFNDYLLATASADHTVALWDLRRLNQ------------RLHTLE-------GHE 325 Query: 284 LAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSE 343 + V WSPH IL+++S D +W DLS G ++T + +S D +F H+ Sbjct: 326 DEVYNVQWSPHDEPILVTSSTDRRVCVW-DLSKIGEEQTVE-DSEDGAPELMFMHGGHTN 383 Query: 344 FVFGADWSLWGKPGYVASTAWDGNLFVWN 372 V W+ K +AS A D L +W+ Sbjct: 384 RVSDLSWNPNNK-WVLASLADDNILQIWS 411 >3CFV-B nrPDB Length = 414 Score = 265 bits (677), Expect = 2e-71, Method: Composition-based stats. Identities = 64/330 (19%), Positives = 121/330 (36%), Gaps = 52/330 (15%) Query: 52 VEVNSFLTQDCLFDLAWNESHENQVLVA-QGDGTLRLFDTTFKE---------FPIAIFK 101 +E + + + A ++ + +FD T P + Sbjct: 117 IECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLR 176 Query: 102 EHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAII 161 H++E + +WN + LS+S D ++ +W I+ Sbjct: 177 GHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGP-----------------KEGKIV 219 Query: 162 LKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGL 221 K FTG S V + ++L S + + ++D R + ++ + Sbjct: 220 DAKAIFTGHS---AVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTA 276 Query: 222 EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNA 281 E FN Y +++ATG D + +WD+R L +LH + Sbjct: 277 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKL------------KLHTFE-------S 317 Query: 282 HGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQH 341 H I +V WSPH+ IL S+ D +W DLS G +++ + ++ D +F H Sbjct: 318 HKDEIFQVHWSPHNETILASSGTDRRLNVW-DLSKIGEEQSAE-DAEDGPPELLFIHGGH 375 Query: 342 SEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 + + W+ +P + S + D + +W Sbjct: 376 TAKISDFSWNP-NEPWVICSVSEDNIMQIW 404 Score = 68.8 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 33/207 (15%), Positives = 75/207 (36%), Gaps = 34/207 (16%) Query: 173 NRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRL------PSGKNQNNFLVH-SGLEALT 225 + V +A++ P + +++ + + +S +FD PSG+ + + E Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 226 CDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLA 285 +N + + D+ + +WDI K + I H Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKA-------------IFTGHSAV 231 Query: 286 IRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFV 345 + V W H ++ S + D IW SN +K ++ ++ H+ V Sbjct: 232 VEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDA-------------HTAEV 278 Query: 346 FGADWSLWGKPGYVASTAWDGNLFVWN 372 ++ + + +A+ + D + +W+ Sbjct: 279 NCLSFNPYSE-FILATGSADKTVALWD 304 Score = 63.0 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 71/209 (33%), Gaps = 22/209 (10%) Query: 165 KSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEAL 224 + T +N V + D S + +GK + ++ E Sbjct: 71 GTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVN 130 Query: 225 TCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI-PNAHG 283 + P+++AT + + ++D + + C ++ H Sbjct: 131 RARYMPQNPHIIATKTPSSDVLVFD-----------YTKHPAKPDPSGECNPDLRLRGHQ 179 Query: 284 LAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSE 343 ++W+ + S L+SAS D T +W N G KE ++ FT HS Sbjct: 180 KEGYGLSWNSNLSGHLLSASDDHTVCLWDI--NAGPKEGKIVDAK-------AIFTGHSA 230 Query: 344 FVFGADWSLWGKPGYVASTAWDGNLFVWN 372 V W L + + S A D L +W+ Sbjct: 231 VVEDVAWHLLHESLF-GSVADDQKLMIWD 258 >5OQL-d nrPDB Length = 446 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 69/339 (20%), Positives = 121/339 (35%), Gaps = 78/339 (23%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL 121 ++ + +++ N + GDG ++++D T ++ H V + N + L Sbjct: 68 GVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTF--TNDKKLL 125 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT-GISKNRNCVY-- 178 S + DG IK+W P S T P+ + P ++ + + T S + C+ Sbjct: 126 SCATDG-IKLWDPYASPSNTT----PIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIW 180 Query: 179 ---------------------QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLV 217 F+ + +++ S + + LFD+R N V Sbjct: 181 DLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLR-------TNMPV 233 Query: 218 HSGLEALTCD---FNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSC 274 + C+ FN +A D+ I I+D R +K Sbjct: 234 IKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKAL----------------- 276 Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 334 I H A+ V +SP L+S SYD T R+WR DA Sbjct: 277 --NIQKGHVAAVMDVEFSPTGEE-LVSGSYDRTIRLWR---------------RDAGHSR 318 Query: 335 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 T+ + VF W++ K Y+ + + DGN+ +W Sbjct: 319 DVYHTKRMQRVFRTMWTMDSK--YILTGSDDGNVRLWRA 355 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 44/248 (17%), Positives = 90/248 (36%), Gaps = 43/248 (17%) Query: 27 AAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLR 86 AA S G + +++ LE +G+ ++ SF+ D + D+ +N+ + + D ++ Sbjct: 169 AASSGQGCI---RIWDLEHSTAGQAIQWPSFV--DTITDVCFNQVETSVIGSVATDRSII 223 Query: 87 LFDTTFKEFPIAIFKEHEREVFSCN---WNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTL 143 LFD P+ H F+CN +N + N +S D +I I+ + + Sbjct: 224 LFDLRTN-MPVIKTVLH----FACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNI 278 Query: 144 TPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFD 203 + V +FSP + LV S S + L+ Sbjct: 279 Q--------------------------KGHVAAVMDVEFSPTGEELV-SGSYDRTIRLW- 310 Query: 204 IRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKR 263 R +G +++ + + + TG D +R+W ++ ++ Sbjct: 311 -RRDAGHSRDVYHTKRMQRVFRTMW-TMDSKYILTGSDDGNVRLWRANASERSGVKATRQ 368 Query: 264 TVPGQLHN 271 + +N Sbjct: 369 RQALEYNN 376 Score = 53.0 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 36/300 (12%), Positives = 76/300 (25%), Gaps = 67/300 (22%) Query: 133 SPLRKQSLMTLTPRPLEITKMVD------PLNAIILKKKSFTGISKNRNCVYQAQFSPHD 186 R + P E + L + K + + VY + Sbjct: 19 DVQRAPRNLAPELHPFERAREYQRALNAVKLERMFAKPFLGQLGNGHVQGVYSMCKDKNS 78 Query: 187 QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIR 246 N + S SG+ ++D L + + + F + + D I+ Sbjct: 79 LNCIASGSGDGVVKVWD--LTTRDEETWRVAAHNNIVKGLTF--TNDKKLLSCATDG-IK 133 Query: 247 IWDIRMLNKNESATIKRTVPGQLHNSS---------------CINEIPNAHG-------- 283 +WD N + G + S CI H Sbjct: 134 LWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQW 193 Query: 284 ----LAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND---------------------- 317 I V ++ ++++ S + D + ++ +N Sbjct: 194 PSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFACNRIVFNPMEAM 253 Query: 318 -----GAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 ++ H V ++S G+ + S ++D + +W Sbjct: 254 NLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEE--LVSGSYDRTIRLWR 311 >5MZH-A nrPDB Length = 452 Score = 221 bits (563), Expect = 3e-58, Method: Composition-based stats. Identities = 68/349 (19%), Positives = 137/349 (39%), Gaps = 63/349 (18%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 122 L + A+N+S ++ + D T ++++ TF + + H+ V++ +N ++ Sbjct: 97 LTNCAFNKS-GDRFITGSYDRTCKVWN-TFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVT 154 Query: 123 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISK---NRNCVYQ 179 S+D + K+W Q TL EI + + I+ S +K + Sbjct: 155 GSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQER 214 Query: 180 AQFSPHDQ-----------NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDF 228 A + H +L+++ S + + L+D+R +G+ + H G E + F Sbjct: 215 ATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVR--TGQCVHVLSGHRG-EVSSTQF 271 Query: 229 NKYRPYVVATGGVDNAIRIWDIR--------------MLNKNESATIKRTVPGQLHNSS- 273 N Y +V +G +D R+WD+R +L+ A + V S+ Sbjct: 272 N-YAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSAR 330 Query: 274 --------CINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKT 325 C + + H I KV ++P + L++AS D TCR+W + + + Sbjct: 331 LYHTLTGVCQHTLV-GHEGEISKVAFNPQGTR-LITASSDKTCRLWDCDTGECLQ----- 383 Query: 326 NSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGL 374 H++ +F ++ G ++ + + D +W L Sbjct: 384 -----------VLEGHTDEIFSCAFNYEGD--FIITGSKDNTCRIWKAL 419 Score = 64.5 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 3/77 (3%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 122 + +A+N +++ A D T RL+D E + + + H E+FSC +N ++ Sbjct: 350 ISKVAFNP-QGTRLITASSDKTCRLWDCDTGEC-LQVLEGHTDEIFSCAFNY-EGDFIIT 406 Query: 123 SSWDGSIKIWSPLRKQS 139 S D + +IW L S Sbjct: 407 GSKDNTCRIWKALTASS 423 Score = 59.2 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 19/155 (12%), Positives = 47/155 (30%), Gaps = 39/155 (25%) Query: 218 HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINE 277 L C FNK + TG D ++W+ + Sbjct: 92 AHILPLTNCAFNKSGDRFI-TGSYDRTCKVWN-------------------TFTGEEVFT 131 Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFN 337 + H + + ++ + + +++ S+D TC++W + + Sbjct: 132 LE-GHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQ----------------LYYT 174 Query: 338 FTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H + ++ +A+ + D +W+ Sbjct: 175 LKGHQTEIVCLSFNPQST--IIATGSMDNTAKLWD 207 >6QX9-5O nrPDB Length = 357 Score = 177 bits (448), Expect = 7e-45, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 116/301 (38%), Gaps = 59/301 (19%) Query: 91 TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPL---------RKQS-- 139 + + PI + HE EV+ C ++ N S+ +D I +W+ + S Sbjct: 53 SSLQAPIMLLSGHEGEVYCCKFH-PNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGA 111 Query: 140 LMTL---TPRPLEITKMVDPLNAI-----ILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 191 +M L T + + D A+ + K G + N Y A+ P LV Sbjct: 112 VMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ---LVC 168 Query: 192 SCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 251 + S + L+DIR + + + L FN ++ +GG+DN I++WD+R Sbjct: 169 TGSDDGTVKLWDIRKKAAIQ----TFQNTYQVLAVTFNDTSDQII-SGGIDNDIKVWDLR 223 Query: 252 MLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 + H ++ ++ S S L+S + D T R+W Sbjct: 224 QNKLTYTM--------------------RGHADSVTGLSLSSEGS-YLLSNAMDNTVRVW 262 Query: 312 RDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 D+ KE +G++ NF ++ + WS G +A+ + D ++VW Sbjct: 263 -DVRPFAPKE----RCVKIFQGNVHNFEKN---LLRCSWSPDGSK--IAAGSADRFVYVW 312 Query: 372 N 372 + Sbjct: 313 D 313 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 47/302 (15%), Positives = 99/302 (32%), Gaps = 65/302 (21%) Query: 69 NESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGS 128 + + + A D T+ ++D+ E + K H V SC Q + S DG+ Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGER-VKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175 Query: 129 IKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQN 188 +K+W ++KK+ +N V F+ + Sbjct: 176 VKLWD----------------------------IRKKAAIQTFQNTYQVLAVTFN-DTSD 206 Query: 189 LVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 ++S ++ ++D+R + + +++T + + +DN +R+W Sbjct: 207 QIISGGIDNDIKVWDLRQNKL----TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVW 262 Query: 249 DIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTC 308 D+R + G +HN + + +WSP S I + S D Sbjct: 263 DVRPF--APKERCVKIFQGNVHNFE----------KNLLRCSWSPDGSKI-AAGSADRFV 309 Query: 309 RIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNL 368 +W S ++ H+ + + + S + D L Sbjct: 310 YVWDTTSRR----------------ILYKLPGHAGSINEVAFHPD--EPIIISASSDKRL 351 Query: 369 FV 370 ++ Sbjct: 352 YM 353 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 21/148 (14%), Positives = 42/148 (28%), Gaps = 33/148 (22%) Query: 254 NKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR- 312 + + + P + + + + H + + P+ S L SA +D +W Sbjct: 37 QQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNV 95 Query: 313 ----------------------------DLSNDGAKETYKTNSTDATKGSIFNFTQHSEF 344 S K +S + H+ F Sbjct: 96 YGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG--ERVKRLKGHTSF 153 Query: 345 VFGADWSLWGKPGYVASTAWDGNLFVWN 372 V + G P V + + DG + +W+ Sbjct: 154 VNSCYPARRG-PQLVCTGSDDGTVKLWD 180 Score = 41.4 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 13/82 (15%), Positives = 32/82 (39%), Gaps = 3/82 (3%) Query: 46 DRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHER 105 +R +I + N + L +W+ +++ D + ++DTT + + H Sbjct: 271 ERCVKIFQGNVHNFEKNLLRCSWSP-DGSKIAAGSADRFVYVWDTTSRRI-LYKLPGHAG 328 Query: 106 EVFSCNWNLVNRQNFLSSSWDG 127 + ++ +S+S D Sbjct: 329 SINEVAFHPDEP-IIISASSDK 349 >5NNZ-B nrPDB Length = 415 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 61/347 (17%), Positives = 120/347 (34%), Gaps = 63/347 (18%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 122 L ++A N+S + + D T +L+DT E + + H V++ +N + Sbjct: 95 LTNVALNKS-GSCFITGSYDRTCKLWDTASGE-ELNTLEGHRNVVYAIAFNNPYGDKIAT 152 Query: 123 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISK---NRNCVYQ 179 S+D + K+WS + T EI + + ++ S +K +N Sbjct: 153 GSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEV 212 Query: 180 AQFSPHDQ-----------NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDF 228 H + +++ S + ++D +G+ N + H E + F Sbjct: 213 YTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDAD--TGRKVNILIGH-CAEISSASF 269 Query: 229 NKYRPYVVATGGVDNAIRIWDIRM--------------LNKNESATIKRTVPGQLH---- 270 N + ++ TG +D ++WD L+ T K Sbjct: 270 N-WDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTAR 328 Query: 271 -----NSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKT 325 CI ++ H I K++++P N L++ S D T RIW + + Sbjct: 329 IFSAATRKCIAKLE-GHEGEISKISFNPQG-NHLLTGSSDKTARIWDAQTGQCLQ----- 381 Query: 326 NSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H++ +F ++ G V + + D +W Sbjct: 382 -----------VLEGHTDEIFSCAFNYKGN--IVITGSKDNTCRIWR 415 Score = 89.2 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 44/201 (21%), Positives = 82/201 (40%), Gaps = 36/201 (17%) Query: 48 SGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREV 107 +GR +VN + A + +L D T +L+D T + +A H+ E+ Sbjct: 250 TGR--KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKC-VATLTGHDDEI 306 Query: 108 FSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSF 167 ++ + ++S DG+ +I+S ++ + L EI+K+ Sbjct: 307 LDSCFDYT-GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS------------- 352 Query: 168 TGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCD 227 F+P +L+ + S + A ++D + +G+ H+ E +C Sbjct: 353 --------------FNPQGNHLL-TGSSDKTARIWDAQ--TGQCLQVLEGHTD-EIFSCA 394 Query: 228 FNKYRPYVVATGGVDNAIRIW 248 FN Y+ +V TG DN RIW Sbjct: 395 FN-YKGNIVITGSKDNTCRIW 414 >5M25-A nrPDB Length = 434 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 61/307 (19%), Positives = 104/307 (33%), Gaps = 90/307 (29%) Query: 98 AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPL 157 H + V S ++ SSS D IKIW + T++ L I+ Sbjct: 139 FTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTISGHKLGIS------ 191 Query: 158 NAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLV 217 +S D NL++S S + ++D+ SGK Sbjct: 192 ---------------------DVAWS-SDSNLLVSASDDKTLKIWDVS--SGKCLKTLKG 227 Query: 218 HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINE 277 HS C+FN +V +G D ++RIWD++ C+ Sbjct: 228 HSNY-VFCCNFNPQSNLIV-SGSFDESVRIWDVK-------------------TGKCLKT 266 Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFN 337 +P AH + V ++ ++++S+SYD CRIW S K D S Sbjct: 267 LP-AHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLI---DDDNPPVSFVK 321 Query: 338 FTQHSEFVFGAD--------------------------------WSLWGKPGYVASTAWD 365 F+ + +++ A +S+ G + S + D Sbjct: 322 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW-IVSGSED 380 Query: 366 GNLFVWN 372 +++WN Sbjct: 381 NLVYIWN 387 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 56/314 (17%), Positives = 104/314 (33%), Gaps = 72/314 (22%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL 121 + D+AW+ S N ++ A D TL+++D + + + K H VF CN+N + Sbjct: 189 GISDVAWS-SDSNLLVSASDDKTLKIWDVSSGKC-LKTLKGHSNYVFCCNFN-PQSNLIV 245 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQ 181 S S+D S++IW + L TL DP++A+ + Sbjct: 246 SGSFDESVRIWDVKTGKCLKTLPAHS-------DPVSAVHFNR----------------- 281 Query: 182 FSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGV 241 D +L++S S + ++D SG+ + F+ Y++A + Sbjct: 282 ----DGSLIVSSSYDGLCRIWDTA--SGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATL 334 Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKV--TWSPHHSNIL 299 DN +++WD C+ H + +S + Sbjct: 335 DNTLKLWD-------------------YSKGKCLKTY-TGHKNEKYCIFANFSVTGGKWI 374 Query: 300 MSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYV 359 +S S D IW + + H++ V Sbjct: 375 VSGSEDNLVYIWNLQTK----------------EIVQKLQGHTDVVISTACHPTENIIAS 418 Query: 360 ASTAWDGNLFVWNG 373 A+ D + +W Sbjct: 419 AALENDKTIKLWKS 432 Score = 54.5 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 42/132 (31%), Gaps = 23/132 (17%) Query: 241 VDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM 300 DN I I + + ++ P + + + H A+ V +SP+ L Sbjct: 107 EDNDI----IEAHREQIGGSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGE-WLA 161 Query: 301 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA 360 S+S D +IW K + H + WS + Sbjct: 162 SSSADKLIKIWGAYDGKFEKTI----------------SGHKLGISDVAWSSDSN--LLV 203 Query: 361 STAWDGNLFVWN 372 S + D L +W+ Sbjct: 204 SASDDKTLKIWD 215 Score = 32.2 bits (71), Expect = 0.35, Method: Composition-based stats. Identities = 11/56 (19%), Positives = 22/56 (39%), Gaps = 2/56 (3%) Query: 318 GAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 G+ K F H++ V +S G+ ++AS++ D + +W Sbjct: 121 GSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGE--WLASSSADKLIKIWGA 174 >2H9P-A nrPDB Length = 329 Score = 148 bits (373), Expect = 3e-36, Method: Composition-based stats. Identities = 66/333 (19%), Positives = 111/333 (33%), Gaps = 97/333 (29%) Query: 79 AQGDGTLRLFDTTFKEFPI-------AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKI 131 + G L T K P+ H + V S ++ SSS D IKI Sbjct: 8 SSGRENLYFQGTQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKI 66 Query: 132 WSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 191 W + T++ L I+ +S D NL++ Sbjct: 67 WGAYDGKFEKTISGHKLGIS---------------------------DVAWS-SDSNLLV 98 Query: 192 SCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 251 S S + ++D+ SGK HS C+FN +V +G D ++RIWD++ Sbjct: 99 SASDDKTLKIWDVS--SGKCLKTLKGHSNY-VFCCNFNPQSNLIV-SGSFDESVRIWDVK 154 Query: 252 MLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 C+ +P AH + V ++ ++++S+SYD CRIW Sbjct: 155 -------------------TGKCLKTLP-AHSDPVSAVHFN-RDGSLIVSSSYDGLCRIW 193 Query: 312 RDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGAD---------------------- 349 S K D S F+ + +++ A Sbjct: 194 DTASGQCLKTLI---DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 250 Query: 350 ----------WSLWGKPGYVASTAWDGNLFVWN 372 +S+ G + S + D +++WN Sbjct: 251 KNEKYCIFANFSVTGGKW-IVSGSEDNLVYIWN 282 Score = 135 bits (338), Expect = 4e-32, Method: Composition-based stats. Identities = 56/314 (17%), Positives = 104/314 (33%), Gaps = 72/314 (22%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL 121 + D+AW+ S N ++ A D TL+++D + + + K H VF CN+N + Sbjct: 84 GISDVAWS-SDSNLLVSASDDKTLKIWDVSSGKC-LKTLKGHSNYVFCCNFN-PQSNLIV 140 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQ 181 S S+D S++IW + L TL DP++A+ + Sbjct: 141 SGSFDESVRIWDVKTGKCLKTLPAHS-------DPVSAVHFNR----------------- 176 Query: 182 FSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGV 241 D +L++S S + ++D SG+ + F+ Y++A + Sbjct: 177 ----DGSLIVSSSYDGLCRIWDTA--SGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATL 229 Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKV--TWSPHHSNIL 299 DN +++WD C+ H + +S + Sbjct: 230 DNTLKLWD-------------------YSKGKCLKTY-TGHKNEKYCIFANFSVTGGKWI 269 Query: 300 MSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYV 359 +S S D IW + + H++ V Sbjct: 270 VSGSEDNLVYIWNLQTK----------------EIVQKLQGHTDVVISTACHPTENIIAS 313 Query: 360 ASTAWDGNLFVWNG 373 A+ D + +W Sbjct: 314 AALENDKTIKLWKS 327 Score = 30.6 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 9/38 (23%), Positives = 19/38 (50%), Gaps = 2/38 (5%) Query: 336 FNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 F H++ V +S G+ ++AS++ D + +W Sbjct: 34 FTLAGHTKAVSSVKFSPNGE--WLASSSADKLIKIWGA 69 >4PSX-B nrPDB Length = 401 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 53/322 (16%), Positives = 114/322 (35%), Gaps = 50/322 (15%) Query: 52 VEVNSFLTQDCLFDLAWNESHENQVLVA-QGDGTLRLFDTTFKEFPIAIFKEHEREVFSC 110 + + + + A + ++ G GT L+ + E + K H+ ++ Sbjct: 109 IRITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLY--SRSEGLQSTLKFHKDNGYAL 166 Query: 111 NWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGI 170 +++ + + LS S D ++ +W DP + T Sbjct: 167 SFSTLVKGRLLSGSDDHTVALWEVGSG----------------GDPTKPVR------TWN 204 Query: 171 SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNK 230 + + + ++ +++L + S +S + D+R + V T F+ Sbjct: 205 DLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNT---TIDTVKCPQPFNTLAFSH 261 Query: 231 YRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVT 290 + ++A G+D+ + ++D+R + + H A+ + Sbjct: 262 HSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS-------------------GHEDAVNNLE 302 Query: 291 WSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADW 350 +S H +++S+ D +W DL GA++T ++ D I H V D Sbjct: 303 FSTHVDGVVVSSGSDNRLMMW-DLKQIGAEQTPD-DAEDGVPELIMVHAGHRSSVNDFDL 360 Query: 351 SLWGKPGYVASTAWDGNLFVWN 372 + P VAS + L VW Sbjct: 361 NPQ-IPWLVASAEEENILQVWK 381 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 30/174 (17%), Positives = 55/174 (31%), Gaps = 14/174 (8%) Query: 32 FGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTT 91 FG V L + R+ Q LA++ N + A D + L+D Sbjct: 224 FGTVSEDSLLKINDVRANNTTIDTVKCPQP-FNTLAFSHHSSNLLAAAGMDSYVYLYDLR 282 Query: 92 FKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEIT 151 + P+ HE V + ++ +SS D + +W +I Sbjct: 283 NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLK-------------QIG 329 Query: 152 KMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIR 205 P +A + + +R+ V +P LV S + ++ Sbjct: 330 AEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 Score = 34.9 bits (78), Expect = 0.054, Method: Composition-based stats. Identities = 14/100 (14%), Positives = 35/100 (35%), Gaps = 13/100 (13%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDT-------TFKEFP------IAIFKEHERE 106 +D + +L ++ + V+ + D L ++D T + I + H Sbjct: 295 EDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSS 354 Query: 107 VFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPR 146 V + N S+ + +++W ++ P+ Sbjct: 355 VNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPK 394 >6EMK-B nrPDB Length = 303 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 106/277 (38%), Gaps = 56/277 (20%) Query: 71 SHENQVLVAQGDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 +++ ++L G +RL+D T P+A F+ H V S ++ NR ++SS DG+I Sbjct: 41 TNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTI 99 Query: 130 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA--------- 180 K+W +R S+ PR K P+N +++ IS +R+ + Sbjct: 100 KVWD-VRSPSI----PRNY---KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCT 151 Query: 181 -QFSPHDQNLVLSCSGNSYASLFDIRLPSGKN----QNNFLVHSGLEALTCDFNKYRPYV 235 Q +P D + S S S S+ G N S L+ +T F + Y+ Sbjct: 152 HQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT-KFRAHSTYI 210 Query: 236 -----------VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGL 284 +AT D+ R+W I K + + H Sbjct: 211 TRILLSSDVKHLATCSADHTARVWSIDDDFK-------------------LETTLDGHQR 251 Query: 285 AIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKE 321 + +S S L++AS D R+W + + ++ Sbjct: 252 WVWDCAFSA-DSAYLVTASSDHYVRLWDLSTREIVRQ 287 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 43/298 (14%), Positives = 87/298 (29%), Gaps = 69/298 (23%) Query: 120 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM----------------VDPLNAIILK 163 +S+ +D +I+ W L T+ ++ ++ V + Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 Query: 164 KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA 223 +R V F D +++ S + ++D+R PS N+ Sbjct: 65 PNPVASFEGHRGNVTSVSF-QQDNRWMVTSSEDGTIKVWDVRSPS--IPRNYK--HNAPV 119 Query: 224 LTCDFNKYRPYVVATGGVDNAIRIWDI--------------RMLNKNESATIKRTVPGQL 269 + + ++ + D IRIWD+ L A+ + Sbjct: 120 NEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAAN 178 Query: 270 HNSSCI---------------NEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDL 314 +C AH I ++ S L + S D T R+W Sbjct: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSID 237 Query: 315 SNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + + T H +V+ +S Y+ + + D + +W+ Sbjct: 238 DDFKLETTLD---------------GHQRWVWDCAFSADS--AYLVTASSDHYVRLWD 278 Score = 48.4 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 13/100 (13%), Positives = 30/100 (30%), Gaps = 1/100 (1%) Query: 54 VNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWN 113 V F S + D T R++ H+R V+ C ++ Sbjct: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS 259 Query: 114 LVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM 153 +++S D +++W ++ + + Sbjct: 260 AD-SAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 Score = 44.5 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 24/161 (14%), Positives = 52/161 (32%), Gaps = 43/161 (26%) Query: 235 VVATGGVDNAIRIWD-------------------IRMLNKNESATIKRTVPGQLHNSSCI 275 ++ + G D+ IR W+ + + N + +L++ Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 Query: 276 NEIP----NAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDAT 331 N P H + V++ + ++++S D T ++W S + Sbjct: 64 NPNPVASFEGHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSIPRNY--------- 113 Query: 332 KGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 +H+ V G + S DGN+ +W+ Sbjct: 114 --------KHNAPVNEVVIHPN--QGELISCDRDGNIRIWD 144 >6Q8F-A nrPDB Length = 514 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 53/204 (25%), Positives = 84/204 (41%), Gaps = 51/204 (25%) Query: 177 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK--------NQNNFLVHSGLEALTCDF 228 V A+FSP Q LV + S + + +++ +GK Q+NF++ +A+ C Sbjct: 218 VECARFSPDGQYLV-TGSVDGFIEVWN--FTTGKIRKDLKYQAQDNFMMMD--DAVLCMC 272 Query: 229 NKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRK 288 ++ATG D I++W I+ + C+ AH + Sbjct: 273 FSRDTEMLATGAQDGKIKVWKIQ-------------------SGQCLRRFERAHSKGVTC 313 Query: 289 VTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGA 348 +++S S IL SAS+D T RI S KE F HS FV A Sbjct: 314 LSFSKDSSQIL-SASFDQTIRIHGLKSGKTLKE----------------FRGHSSFVNEA 356 Query: 349 DWSLWGKPGYVASTAWDGNLFVWN 372 ++ G Y+ S + DG + +WN Sbjct: 357 TFTQDGH--YIISASSDGTVKIWN 378 Score = 74.2 bits (180), Expect = 9e-14, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 87/253 (34%), Gaps = 49/253 (19%) Query: 83 GTLRLFDTTFKEFPIAIFK----EHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQ 138 G + D ++FP + + + V ++ Q ++ S DG I++W+ + Sbjct: 190 GKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPD-GQYLVTGSVDGFIEVWNFTTGK 248 Query: 139 SLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSY 198 L + + M+D + V FS D ++ + + + Sbjct: 249 IRKDLKYQAQDNFMMMD-------------------DAVLCMCFS-RDTEMLATGAQDGK 288 Query: 199 ASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNES 258 ++ I+ SG+ F F+K ++ + D IRI ++ Sbjct: 289 IKVWKIQ--SGQCLRRFERAHSKGVTCLSFSKDSSQIL-SASFDQTIRIHGLK------- 338 Query: 259 ATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDG 318 + + E H + + T++ + ++SAS D T +IW + + Sbjct: 339 ------------SGKTLKEF-RGHSSFVNEATFT-QDGHYIISASSDGTVKIWNMKTTEC 384 Query: 319 AKETYKTNSTDAT 331 + ST T Sbjct: 385 SNTFKSLGSTAGT 397 Score = 73.8 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 36/287 (12%), Positives = 92/287 (32%), Gaps = 62/287 (21%) Query: 55 NSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNL 114 N + D + + ++ E + DG ++++ + + H + V +++ Sbjct: 260 NFMMMDDAVLCMCFSRDTE-MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSK 318 Query: 115 VNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNR 174 + Q LS+S+D +I+I ++L Sbjct: 319 DSSQ-ILSASFDQTIRIHGLKSGKTLKEFRGHS--------------------------- 350 Query: 175 NCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF-----LVHSGLEALTCDFN 229 + V +A F+ ++ S S + +++++ + + N F + + + Sbjct: 351 SFVNEATFTQDGHYII-SASSDGTVKIWNMK--TTECSNTFKSLGSTAGTDITVNSVILL 407 Query: 230 KYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRT-----------------VPGQLHNS 272 P N + I +++ ++ KR G+ Sbjct: 408 PKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVL 467 Query: 273 SCINEIPN-------AHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 312 C + + H + + PH N++ + S D ++W+ Sbjct: 468 YCFSTVTGKLERTLTVHEKDVIGIAHHPH-QNLIATYSEDGLLKLWK 513 Score = 42.2 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 27/209 (12%), Positives = 68/209 (32%), Gaps = 37/209 (17%) Query: 47 RSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHERE 106 +SG+ ++ F + A + ++ A DGT+++++ E Sbjct: 338 KSGKTLK--EFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC----------- 384 Query: 107 VFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILK--- 163 + + ++ D ++ S++ L P +I+ Sbjct: 385 ------SNTFKSLGSTAGTDITV--------NSVILLPKNPEHFVVCNRSNTVVIMNMQG 430 Query: 164 --KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGL 221 +SF+ + SP + + L+ +GK + VH Sbjct: 431 QIVRSFSSGKREGGDFVCCALSPRGEWIYCVGED---FVLYCFSTVTGKLERTLTVH-EK 486 Query: 222 EALTCDFNKYRPYVVATGGVDNAIRIWDI 250 + + + ++ ++AT D +++W Sbjct: 487 DVIGIAHHPHQN-LIATYSEDGLLKLWKP 514 Score = 37.6 bits (85), Expect = 0.008, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 35/94 (37%), Gaps = 3/94 (3%) Query: 42 ILEIDRSGRIVE-VNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIF 100 ++ ++ G+IV +S + F + D L F T + Sbjct: 423 VVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLE-RTL 481 Query: 101 KEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSP 134 HE++V + ++ + S DG +K+W P Sbjct: 482 TVHEKDVIGIA-HHPHQNLIATYSEDGLLKLWKP 514 >6QX9-4B nrPDB Length = 522 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 65/355 (18%), Positives = 122/355 (34%), Gaps = 71/355 (20%) Query: 44 EIDRSGRIVEVNSFLTQDCL---FDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIF 100 E+ +S R +N+F +Q + + A G +L+ + Sbjct: 213 ELHKSLR--SLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSV-PDCNLLHTL 269 Query: 101 KEHEREVFSCNWNL-------VNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM 153 + H V + ++ N S + DGS+K+WS + + + + + ++ Sbjct: 270 RGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARV 329 Query: 154 VDPLNAIILKKKSFTGI---------------SKNRNCVYQAQFSPHDQNLVLSCSGNSY 198 + + L + + VY F D +L + +++ Sbjct: 330 MWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFH-QDGSLAGTGGLDAF 388 Query: 199 ASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNES 258 ++D+R +G+ H E +F+ Y +ATG DN ++WD+R Sbjct: 389 GRVWDLR--TGRCIMFLEGH-LKEIYGINFSP-NGYHIATGSGDNTCKVWDLR------- 437 Query: 259 ATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDG 318 C+ IP AH + V + P H N L++ +YD T +IW Sbjct: 438 ------------QRRCVYTIP-AHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSP 484 Query: 319 AKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 K H V G D S G+ +A+ ++D +W Sbjct: 485 LKTLA----------------GHEGKVMGLDISSDGQ--LIATCSYDRTFKLWMA 521 >5FL8-q nrPDB Length = 515 Score = 125 bits (314), Expect = 2e-29, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 98/255 (38%), Gaps = 53/255 (20%) Query: 126 DGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKK--KSFTGISKNRNCVYQAQFS 183 D + ++S L K + +IT + P +K +S + I+ + + + + F+ Sbjct: 96 DITDNLYSSLIKPGYNSTED---QITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFA 152 Query: 184 PHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDN 243 PH + +++ +G++ A ++D + + L L ++ V+ATG +DN Sbjct: 153 PHTSSRMVTGAGDNTARIWDCD---TQTPMHTLKGHYNWVLCVSWSP-DGEVIATGSMDN 208 Query: 244 AIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH------SN 297 IR+WD + + C+ + H I ++W P H Sbjct: 209 TIRLWDPK-------------------SGQCLGDALRGHSKWITSLSWEPIHLVKPGSKP 249 Query: 298 ILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPG 357 L S+S D T +IW +S + + H+ V W G G Sbjct: 250 RLASSSKDGTIKIWDTVSRVCQ----------------YTMSGHTNSVSCVKW---GGQG 290 Query: 358 YVASTAWDGNLFVWN 372 + S + D + VW+ Sbjct: 291 LLYSGSHDRTVRVWD 305 Score = 114 bits (284), Expect = 9e-26, Method: Composition-based stats. Identities = 62/351 (17%), Positives = 113/351 (32%), Gaps = 73/351 (20%) Query: 67 AWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWD 126 A+ ++++ GD T R++D + P+ K H V +W+ + + S D Sbjct: 150 AFAPHTSSRMVTGAGDNTARIWDCDT-QTPMHTLKGHYNWVLCVSWSPD-GEVIATGSMD 207 Query: 127 GSIKIWSPLRKQSL-MTLTPRPLEITK-------MVDPLNAIILKKKSFTGI-------- 170 +I++W P Q L L IT +V P + L S G Sbjct: 208 NTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVS 267 Query: 171 -------SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG-LE 222 S + N V ++ L+ S S + ++DI G+ N H+ + Sbjct: 268 RVCQYTMSGHTNSVSCVKWGGQG--LLYSGSHDRTVRVWDI-NSQGRCINILKSHAHWVN 324 Query: 223 ALTCDFNKYRPYVVATGGVDNAIRIWD-IRMLNKNESATIKRTVPGQLHNSSCINEIPN- 280 L+ Y + G D+ + K ++ ++ + + Sbjct: 325 HLSLS----TDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDD 380 Query: 281 -------------------AHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKE 321 H + V +SP ++SAS+D + ++W Sbjct: 381 YTMFLWNPLKSTKPIARMTGHQKLVNHVAFSP-DGRYIVSASFDNSIKLWDGRDGK---- 435 Query: 322 TYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 I F H V+ WS + + S + D L VW+ Sbjct: 436 ------------FISTFRGHVASVYQVAWSSDCR--LLVSCSKDTTLKVWD 472 Score = 82.7 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 40/183 (21%), Positives = 71/183 (38%), Gaps = 33/183 (18%) Query: 66 LAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSW 125 N + E ++ A D T+ L++ PIA H++ V ++ + +S+S+ Sbjct: 364 CKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPD-GRYIVSASF 422 Query: 126 DGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPH 185 D SIK+W + + T VYQ +S Sbjct: 423 DNSIKLWDGRDGKFISTFRGH---------------------------VASVYQVAWS-S 454 Query: 186 DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAI 245 D L++SCS ++ ++D+R + + L E T D+ V +GG D + Sbjct: 455 DCRLLVSCSKDTTLKVWDVR---TRKLSVDLPGHKDEVYTVDW-SVDGKRVCSGGKDKMV 510 Query: 246 RIW 248 R+W Sbjct: 511 RLW 513 >5WLC-LU nrPDB Length = 489 Score = 125 bits (312), Expect = 4e-29, Method: Composition-based stats. Identities = 53/353 (15%), Positives = 115/353 (32%), Gaps = 81/353 (22%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLV---- 115 +D ++ +A N N++ DG ++ ++ + +E + FK H V Sbjct: 67 RDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFV-SFKAHYGLVTGLCVTQPRFHD 125 Query: 116 ------NRQNFLSSSWDGSIKIW----SPLRKQS------------LMTLTPRPLEITKM 153 ++ LS S D ++K+W ++ L+ + Sbjct: 126 KKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGI 185 Query: 154 VDPLNAIILKKKSFTGISKNRNCVYQA-------------QFSPHDQNLVLSCSGNSYAS 200 + N + +F+ ++ +++ S ++ Sbjct: 186 DSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIV 245 Query: 201 LFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESAT 260 L+D+R S + + +N + T D+ +D+R L+++ + Sbjct: 246 LYDLRTNS----PTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVF 301 Query: 261 IKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAK 320 H A+ V +SP I ++ SYD + RI++ Sbjct: 302 -------------------KDHVSAVMDVDFSPTGDEI-VTGSYDKSIRIYKT------- 334 Query: 321 ETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 + T+ + VF +S+ K Y+ S + DGN+ +W Sbjct: 335 --------NHGHSREIYHTKRMQHVFQVKYSMDSK--YIISGSDDGNVRLWRS 377 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 30/228 (13%), Positives = 78/228 (34%), Gaps = 34/228 (14%) Query: 36 GNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEF 95 G K+ + +++R + +++ D + L +N++ + + D ++ L+D Sbjct: 197 GGAKIHLWDVNRLKPVSDLS--WGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSP 254 Query: 96 PIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVD 155 I + + WN + NF++++ D + + M R L + K Sbjct: 255 TQKIVQTMRTN--AICWNPMEAFNFVTANEDHNAYYYD-------MRNLSRSLNVFK--- 302 Query: 156 PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 215 + + V FSP +++ S + ++ G ++ + Sbjct: 303 ----------------DHVSAVMDVDFSPTGDE-IVTGSYDKSIRIYKT--NHGHSREIY 343 Query: 216 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKR 263 + + +G D +R+W + ++ T + Sbjct: 344 HTKRMQHVFQVKY-SMDSKYIISGSDDGNVRLWRSKAWERSNVKTTRE 390 >5FVM-C nrPDB Length = 303 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 103/277 (37%), Gaps = 56/277 (20%) Query: 71 SHENQVLVAQGDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 + + + L A G +RL+D + P++ F+ H+ V S + NR +SSS DG+I Sbjct: 41 TSDKKYLAAAGHLHVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQQENRW-MVSSSEDGTI 99 Query: 130 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA--------- 180 K+W +R S+ K P+N + + IS +++ + Sbjct: 100 KVWD-VRSPSVQ-------RNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCT 151 Query: 181 -QFSPHDQNLVLSCSGNSYASLFDIRLPSGKN----QNNFLVHSGLEALTCDFNKYRPYV 235 Q +P D + S S S S+ G + S LE +T F + Y+ Sbjct: 152 NQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVT-KFKSHTKYI 210 Query: 236 -----------VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGL 284 +AT D+ R+W+I + + + H Sbjct: 211 TRVLLSADVKNLATCSADHTARVWNIEDNYQ-------------------LETTLDGHQR 251 Query: 285 AIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKE 321 + +S S L++A D R+W +++ ++ Sbjct: 252 WVWDCAFSA-DSAYLVTACSDHYVRLWDLSTSEIVRQ 287 Score = 71.5 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 44/297 (14%), Positives = 86/297 (28%), Gaps = 67/297 (22%) Query: 120 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITK----------------MVDPLNAIILK 163 S+ +D +I+ W L T+ ++ + V + Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSNN 64 Query: 164 KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA 223 + ++ V F + ++S S + ++D+R PS Q N+ Sbjct: 65 PNPVSSFEGHKGNVTSIAF-QQENRWMVSSSEDGTIKVWDVRSPS--VQRNYK--HNAPV 119 Query: 224 LTCDFNKYRPYVVATGGVDNAIRIWDI--------------RMLNKNESATIKRTVPGQL 269 + + ++ + D IRIWD+ L A+ + Sbjct: 120 NEVAIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGN 178 Query: 270 HNSSCINEIPNAHGLAIR---KVTWSPHHSNI-----------LMSASYDMTCRIWRDLS 315 + +C H A + H I L + S D T R+W Sbjct: 179 NKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIED 238 Query: 316 NDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 N + T H +V+ +S Y+ + D + +W+ Sbjct: 239 NYQLETTLD---------------GHQRWVWDCAFSADS--AYLVTACSDHYVRLWD 278 Score = 48.4 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 11/100 (11%), Positives = 30/100 (30%), Gaps = 1/100 (1%) Query: 54 VNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWN 113 V F + + + D T R+++ H+R V+ C ++ Sbjct: 200 VTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQLETTLDGHQRWVWDCAFS 259 Query: 114 LVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM 153 +++ D +++W + + + Sbjct: 260 AD-SAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCV 298 Score = 44.5 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 24/161 (14%), Positives = 53/161 (32%), Gaps = 43/161 (26%) Query: 235 VVATGGVDNAIRIWD-------------------IRMLNKNESATIKRTVPGQLHNSSCI 275 ++A+ G D+ IR W+ + + + + + +L++ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSN 63 Query: 276 NEIP----NAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDAT 331 N P H + + + + ++S+S D T ++W S + Sbjct: 64 NPNPVSSFEGHKGNVTSIAFQQEN-RWMVSSSEDGTIKVWDVRSPSVQRNY--------- 113 Query: 332 KGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 +H+ V G + S DGN+ +W+ Sbjct: 114 --------KHNAPVNEVAIHPN--QGELISCDQDGNIRIWD 144 >6F3T-A nrPDB Length = 608 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 49/267 (18%), Positives = 84/267 (31%), Gaps = 43/267 (16%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 S + + D R+ D + I H V+ +++ R LSSS DG+++ Sbjct: 319 SDLSLIDKESDDVLERIMDEKTA-SELKILYGHSGPVYGASFSPD-RNYLLSSSEDGTVR 376 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIIL---------------KKKSFTGISKNRN 175 +WS L+ + + + + Sbjct: 377 LWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLA 436 Query: 176 CVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYV 235 V +F P + N V + S + L+D+ +G F H G + F+ Sbjct: 437 DVNCTRFHP-NSNYVATGSADRTVRLWDV--LNGNCVRIFTGHKG-PIHSLTFSP-NGRF 491 Query: 236 VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 295 +ATG D + +WDI + H + + +S Sbjct: 492 LATGATDGRVLLWDI--------------------GHGLMVGELKGHTDTVCSLRFS-RD 530 Query: 296 SNILMSASYDMTCRIWRDLSNDGAKET 322 IL S S D T R+W + ET Sbjct: 531 GEILASGSMDNTVRLWDAIKAFEDLET 557 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 26/165 (15%), Positives = 51/165 (30%), Gaps = 36/165 (21%) Query: 46 DRSGRIVEVNSFLT------QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAI 99 DR R+ + + + + N V D T+RL+D + I Sbjct: 414 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC-VRI 472 Query: 100 FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNA 159 F H+ + S + N + + + DG + +W + L Sbjct: 473 FTGHKGPIHSLTF-SPNGRFLATGATDGRVLLWDIGHGLMVGELKGH------------- 518 Query: 160 IILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI 204 + V +FS + ++ S S ++ L+D Sbjct: 519 --------------TDTVCSLRFSRDGE-ILASGSMDNTVRLWDA 548 Score = 66.5 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 30/189 (15%), Positives = 59/189 (31%), Gaps = 43/189 (22%) Query: 186 DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAI 245 D +L+ S + + D + HSG F+ R Y++++ D + Sbjct: 320 DLSLIDKESDDVLERIMD--EKTASELKILYGHSG-PVYGASFSPDRNYLLSS-SEDGTV 375 Query: 246 RIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYD 305 R+W ++ +C+ H + +SP+ +S +D Sbjct: 376 RLWSLQ-------------------TFTCLVGY-KGHNYPVWDTQFSPYG-YYFVSGGHD 414 Query: 306 MTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWD 365 R+W + F H V + YVA+ + D Sbjct: 415 RVARLWATDHYQPLR----------------IFAGHLADVNCTRFHPNSN--YVATGSAD 456 Query: 366 GNLFVWNGL 374 + +W+ L Sbjct: 457 RTVRLWDVL 465 >6MZM-G nrPDB Length = 800 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 76/240 (31%), Gaps = 42/240 (17%) Query: 98 AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPL 157 I H V+ +++ R LSSS DG++++WS L+ + Sbjct: 537 KILYGHSGPVYGASFSPD-RNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595 Query: 158 NAIIL---------------KKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLF 202 + + + V +F P + N V + S + L+ Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP-NSNYVATGSADRTVRLW 654 Query: 203 DIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIK 262 D+ +G F H G + F+ +ATG D + +WDI Sbjct: 655 DV--LNGNCVRIFTGHKG-PIHSLTFSP-NGRFLATGATDGRVLLWDI------------ 698 Query: 263 RTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKET 322 + H + + +S IL S S D T R+W + ET Sbjct: 699 --------GHGLMVGELKGHTDTVCSLRFS-RDGEILASGSMDNTVRLWDAIKAFEDLET 749 Score = 88.4 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 35/239 (14%), Positives = 80/239 (33%), Gaps = 39/239 (16%) Query: 70 ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 + + D RL+ T P+ IF H +V ++ N + S D ++ Sbjct: 594 SPYGYYFVSGGHDRVARLW-ATDHYQPLRIFAGHLADVNCTRFH-PNSNYVATGSADRTV 651 Query: 130 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNL 189 ++W L + T + ++ FSP+ + L Sbjct: 652 RLWDVLNGNCVRIFTGH---------------------------KGPIHSLTFSPNGRFL 684 Query: 190 VLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWD 249 + + + L+DI G H+ + + ++A+G +DN +R+WD Sbjct: 685 -ATGATDGRVLLWDI--GHGLMVGELKGHT--DTVCSLRFSRDGEILASGSMDNTVRLWD 739 Query: 250 I----RMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASY 304 L ++ T + ++ + + + ++ + +L + +Y Sbjct: 740 AIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRN-LVLAAGAY 797 Score = 74.2 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 26/165 (15%), Positives = 51/165 (30%), Gaps = 36/165 (21%) Query: 46 DRSGRIVEVNSFLT------QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAI 99 DR R+ + + + + N V D T+RL+D + I Sbjct: 606 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC-VRI 664 Query: 100 FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNA 159 F H+ + S + N + + + DG + +W + L Sbjct: 665 FTGHKGPIHSLTF-SPNGRFLATGATDGRVLLWDIGHGLMVGELKGH------------- 710 Query: 160 IILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI 204 + V +FS + ++ S S ++ L+D Sbjct: 711 --------------TDTVCSLRFSRDGE-ILASGSMDNTVRLWDA 740 Score = 61.9 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 23/156 (14%), Positives = 47/156 (30%), Gaps = 40/156 (25%) Query: 219 SGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 F+ R Y++++ D +R+W ++ +C+ Sbjct: 542 HSGPVYGASFSPDRNYLLSS-SEDGTVRLWSLQ-------------------TFTCLVGY 581 Query: 279 PNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNF 338 H + +SP+ +S +D R+W + F Sbjct: 582 -KGHNYPVWDTQFSPYG-YYFVSGGHDRVARLWATDHYQPLR----------------IF 623 Query: 339 TQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGL 374 H V + YVA+ + D + +W+ L Sbjct: 624 AGHLADVNCTRFHPNSN--YVATGSADRTVRLWDVL 657 >6HQA-B nrPDB Length = 722 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 81/248 (32%), Gaps = 41/248 (16%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 H V+ +++ NR +S S D ++++WS L++ + + Sbjct: 448 RLVGHSGAVYGVDFSPDNR-YLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM 506 Query: 159 AIILKKKSFTGI---------------SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFD 203 S + + N V +F P+ L + S + A ++D Sbjct: 507 GHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLF-TGSSDKTARMWD 565 Query: 204 IRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKR 263 I G+ F+ HSG + +A+ G D+ + +WDI Sbjct: 566 IA--RGECVRVFMGHSGA-INCLAVSP-DGRWLASAGEDSVVCLWDI------------- 608 Query: 264 TVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETY 323 I + +I + +S + +L+S D + R+W N + Sbjct: 609 ------STGRRIKAMRGHGRSSIYSLAFSREGT-VLVSTGADNSVRVWDVKKNTNSPSAQ 661 Query: 324 KTNSTDAT 331 D T Sbjct: 662 PEPINDVT 669 Score = 93.8 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 51/276 (18%), Positives = 89/276 (32%), Gaps = 51/276 (18%) Query: 97 IAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDP 156 + F ++ +N + S D IK+WS L P + Sbjct: 383 MYTFHNTNNDLTCLKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPY------NQ 435 Query: 157 LNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFL 216 N + K + + VY FSP ++ L+ SCS + L+ + + ++ Sbjct: 436 QNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLI-SCSEDKTVRLWSLDTYT--CLVSYK 492 Query: 217 VHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCIN 276 HS F+ + AT D R+W + P + Sbjct: 493 GHSS-SVWDVKFSPM-GHYFATASHDQTARLW-----------SCDHIYPLR-------- 531 Query: 277 EIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF 336 I H + V + P +S L + S D T R+W + + Sbjct: 532 -IFAGHLNDVDCVEFHP-NSTYLFTGSSDKTARMWDIARGECVR---------------- 573 Query: 337 NFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 F HS + S G+ ++AS D + +W+ Sbjct: 574 VFMGHSGAINCLAVSPDGR--WLASAGEDSVVCLWD 607 Score = 87.3 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 49/274 (17%), Positives = 91/274 (33%), Gaps = 58/274 (21%) Query: 8 GFSG--YGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSF---LTQDC 62 G SG YGV +SP DNR ++ D++ R+ ++++ ++ Sbjct: 451 GHSGAVYGVDFSP--DNRYLISCSE---------------DKTVRLWSLDTYTCLVSYKG 493 Query: 63 LFDLAWN---ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQN 119 W+ + A D T RL+ +P+ IF H +V ++ N Sbjct: 494 HSSSVWDVKFSPMGHYFATASHDQTARLWSCD-HIYPLRIFAGHLNDVDCVEFH-PNSTY 551 Query: 120 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQ 179 + S D + ++W R + + + Sbjct: 552 LFTGSSDKTARMWDIARGECVRVFMGHS---------------------------GAINC 584 Query: 180 AQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATG 239 SP + L S +S L+DI +G+ H + F V+ + Sbjct: 585 LAVSPDGRWL-ASAGEDSVVCLWDIS--TGRRIKAMRGHGRSSIYSLAF-SREGTVLVST 640 Query: 240 GVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSS 273 G DN++R+WD++ + SA + Sbjct: 641 GADNSVRVWDVKKNTNSPSAQPEPINDVTAQGIQ 674 >3FM0-A nrPDB Length = 345 Score = 104 bits (260), Expect = 5e-23, Method: Composition-based stats. Identities = 54/314 (17%), Positives = 100/314 (31%), Gaps = 43/314 (13%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFP-IAIFKEHEREVFSCNWNLVNRQ 118 Q + +AW+ N + A D T ++ +F + + HE EV S W + Sbjct: 61 QRTVRKVAWSPC-GNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAW-APSGN 118 Query: 119 NFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVY 178 + S D S+ +W + + + ++ + V Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECV------------------------SVLNSHTQDVK 154 Query: 179 QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVAT 238 + P Q L+ S S + L+ H + F+ +A+ Sbjct: 155 HVVWHP-SQELLASASYDDTVKLYREEEDDWVCCATLEGHEST-VWSLAFDP-SGQRLAS 211 Query: 239 GGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNI 298 D +RIW G + CI + H I + W + Sbjct: 212 CSDDRTVRIW----RQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWC-QLTGA 266 Query: 299 LMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGY 358 L +A D R++++ N ++ + HS+ V W+ +PG Sbjct: 267 LATACGDDAIRVFQEDPNSDPQQPT-------FSLTAHLHQAHSQDVNCVAWNPK-EPGL 318 Query: 359 VASTAWDGNLFVWN 372 +AS + DG + W Sbjct: 319 LASCSDDGEVAFWK 332 Score = 85.3 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 49/308 (15%), Positives = 100/308 (32%), Gaps = 52/308 (16%) Query: 66 LAWNESHENQVLVAQGDGTLRLFDTTFKE--FPIAIFKEHEREVFSCNWNLVNRQNFLSS 123 LAWN + + GD +R++ T + + H+R V W S+ Sbjct: 22 LAWNPA-GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAW-SPCGNYLASA 79 Query: 124 SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFS 183 S+D + IW + + T + + N V ++ Sbjct: 80 SFDATTCIW-----------KKNQDDFECV--------------TTLEGHENEVKSVAWA 114 Query: 184 PHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDN 243 P NL+ +CS + ++++ + L + ++ ++A+ D+ Sbjct: 115 PSG-NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP-SQELLASASYDD 172 Query: 244 AIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSAS 303 ++++ + + C + H + + + P L S S Sbjct: 173 TVKLY-----------------REEEDDWVCCATLE-GHESTVWSLAFDPSGQR-LASCS 213 Query: 304 YDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTA 363 D T RIWR + + S + K HS ++ W G +A+ Sbjct: 214 DDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQL--TGALATAC 271 Query: 364 WDGNLFVW 371 D + V+ Sbjct: 272 GDDAIRVF 279 Score = 77.3 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 41/228 (17%), Positives = 79/228 (34%), Gaps = 32/228 (14%) Query: 40 LFILEIDRSGR--IVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPI 97 +++ E+D V V + TQD + + W+ S E + A D T++L+ +E Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQD-VKHVVWHPSQE-LLASASYDDTVKLY----REEED 182 Query: 98 -----AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITK 152 A + HE V+S ++ + Q S S D +++IW L + Sbjct: 183 DWVCCATLEGHESTVWSLAFD-PSGQRLASCSDDRTVRIWRQY-------LPGNEQGVAC 234 Query: 153 MVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQ 212 + K T + +Y + L +C ++ +F S Q Sbjct: 235 SGSDPSW----KCICTLSGFHSRTIYDIAWCQLTGALATACGDDA-IRVFQEDPNSDPQQ 289 Query: 213 NNFLV------HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 F + + +N P ++A+ D + W + Sbjct: 290 PTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPE 337 Score = 69.2 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 82/263 (31%), Gaps = 62/263 (23%) Query: 110 CNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTG 169 WN S D I+IW T I K V Sbjct: 22 LAWN-PAGTLLASCGGDRRIRIWG----------TEGDSWICKSV--------------L 56 Query: 170 ISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFN 229 ++ V + +SP L S S ++ ++ + H E + + Sbjct: 57 SEGHQRTVRKVAWSPCGNYL-ASASFDATTCIWKKNQDDFECVTTLEGHEN-EVKSVAWA 114 Query: 230 KYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKV 289 ++AT D ++ +W++ + C+ + N+H ++ V Sbjct: 115 P-SGNLLATCSRDKSVWVWEV----------------DEEDEYECV-SVLNSHTQDVKHV 156 Query: 290 TWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGAD 349 W P +L SASYD T +++R +E H V+ Sbjct: 157 VWHP-SQELLASASYDDTVKLYR------EEEDDWVCCA--------TLEGHESTVWSLA 201 Query: 350 WSLWGKPGYVASTAWDGNLFVWN 372 + G+ +AS + D + +W Sbjct: 202 FDPSGQR--LASCSDDRTVRIWR 222 >1VYH-C nrPDB Length = 410 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 53/334 (15%), Positives = 102/334 (30%), Gaps = 85/334 (25%) Query: 76 VLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPL 135 ++ A D T++++D +F K H V +++ + S S D +IK+W Sbjct: 123 MVSASEDATIKVWDYETGDFE-RTLKGHTDSVQDISFDHS-GKLLASCSADMTIKLWDFQ 180 Query: 136 RKQSLMTLTPRPLEITKMVDPLN------------------AIILKKKSFTGISKNRNCV 177 + + T+ ++ + N K+FTG + V Sbjct: 181 GFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV 240 Query: 178 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPY--- 234 Q D L+ SCS + ++ + + + + H + + Y Sbjct: 241 RPNQ----DGTLIASCSNDQTVRVWVVA--TKECKAELREHRHV-VECISWAPESSYSSI 293 Query: 235 ----------------VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 + +G D I++WD+ C+ + Sbjct: 294 SEATGSETKKSGKPGPFLLSGSRDKTIKMWDV-------------------STGMCLMTL 334 Query: 279 PNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNF 338 H +R V + ++S + D T R+W + K Sbjct: 335 V-GHDNWVRGVLFHS-GGKFILSCADDKTLRVWDYKNKRCMKTL---------------- 376 Query: 339 TQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H FV D+ YV + + D + VW Sbjct: 377 NAHEHFVTSLDFH--KTAPYVVTGSVDQTVKVWE 408 Score = 96.1 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 50/301 (16%), Positives = 93/301 (30%), Gaps = 50/301 (16%) Query: 92 FKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEIT 151 + H V ++ V +S+S D +IK+W TL + Sbjct: 96 PRPPEKYALSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETGDFERTLKGHTDSVQ 154 Query: 152 KMVDPLNAIILKKKSFTGISK-----NRNCVYQAQFSPHDQNL---------VLSCSGNS 197 + + +L S K C+ H+ + ++S S + Sbjct: 155 DISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDK 214 Query: 198 YASLFDIRLPSGKNQNNFLVHSGLEALTCDFNK-YRPYVVATGGVDNAIRIWDIRMLNKN 256 +++++ +G F H ++A+ D +R+W Sbjct: 215 TIKMWEVQ--TGYCVKTFTGHREW---VRMVRPNQDGTLIASCSNDQTVRVW------VV 263 Query: 257 ESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH-----SNILMSASYDMTCRIW 311 + K + H CI+ P + +I + T S L+S S D T ++W Sbjct: 264 ATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323 Query: 312 RDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 + H +V G + GK ++ S A D L VW Sbjct: 324 DVSTGMCLMTLV----------------GHDNWVRGVLFHSGGK--FILSCADDKTLRVW 365 Query: 372 N 372 + Sbjct: 366 D 366 Score = 83.0 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 44/217 (20%), Positives = 69/217 (31%), Gaps = 52/217 (23%) Query: 54 VNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWN 113 V +F + + D T+R++ KE A +EH V +W Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECK-AELREHRHVVECISWA 285 Query: 114 LVNRQN-------------------FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMV 154 + + LS S D +IK+W LMTL Sbjct: 286 PESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD------- 338 Query: 155 DPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNN 214 N V F +LSC+ + ++D + + Sbjct: 339 --------------------NWVRGVLFH-SGGKFILSCADDKTLRVWDYKNK--RCMKT 375 Query: 215 FLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 251 H + DF+K PYVV TG VD +++W+ R Sbjct: 376 LNAHEHF-VTSLDFHKTAPYVV-TGSVDQTVKVWECR 410 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 38/95 (40%), Gaps = 19/95 (20%) Query: 281 AHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQ 340 H + +V + P S +++SAS D T ++W + D + Sbjct: 106 GHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETGDFERTL----------------KG 148 Query: 341 HSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG 375 H++ V + GK +AS + D + +W+ G Sbjct: 149 HTDSVQDISFDHSGK--LLASCSADMTIKLWDFQG 181 >5Z56-q nrPDB Length = 504 Score = 99 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 52/288 (18%), Positives = 102/288 (35%), Gaps = 46/288 (15%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL 121 + L S N++L D + +FD + E +A K H ++V S ++ Sbjct: 223 GILALDLCPSDTNKILTGGADKNVVVFDKSS-EQILATLKGHTKKVTSVVFHPSQD-LVF 280 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMV------DPLNAIILKKKSFTGISKNRN 175 S+S D +I+IWS + + +T + L++ + +F+ I R Sbjct: 281 SASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRV 340 Query: 176 CVY-----------QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEAL 224 AQF P + + + +S ++D++ + N NF HSG + Sbjct: 341 LTKVTDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDLKERT--NVANFPGHSG--PI 395 Query: 225 TCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIP----- 279 T Y +AT D+++++WD+R L ++ + + Sbjct: 396 TSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGT 455 Query: 280 ----------------NAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 H V + HH+ + S D + + + Sbjct: 456 DVQIYICKQWTEILHFTEHSGLTTGVAFG-HHAKFIASTGMDRSLKFY 502 Score = 66.1 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 44/262 (16%), Positives = 85/262 (32%), Gaps = 54/262 (20%) Query: 135 LRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCS 194 R +++ +P E++K + + L S GI C P D N +L+ Sbjct: 189 KRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLC-------PSDTNKILTGG 241 Query: 195 GNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 + +FD S + L + + F+ + +V + D IRIW + + Sbjct: 242 ADKNVVVFD---KSSEQILATLKGHTKKVTSVVFHPSQD-LVFSASPDATIRIWSVPNAS 297 Query: 255 --------------KNESATIKRTVPGQLHNSSCINEIPNAH----------GLAIRKVT 290 + AT + ++I G ++ Sbjct: 298 CVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQ 357 Query: 291 WSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADW 350 + P I + + D +IW ++ NF HS + + Sbjct: 358 FHP-DGLIFGTGTMDSQIKIWDLKER----------------TNVANFPGHSGPITSIAF 400 Query: 351 SLWGKPGYVASTAWDGNLFVWN 372 S G Y+A+ A D ++ +W+ Sbjct: 401 SENG--YYLATAADDSSVKLWD 420 Score = 56.5 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 23/172 (13%), Positives = 56/172 (32%), Gaps = 17/172 (9%) Query: 47 RSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHERE 106 ++GR++ + T C A D ++++D + +A F H Sbjct: 336 QTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN-VANFPGHSGP 394 Query: 107 VFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT-PRPLEITKMVDPLNAIILKKK 165 + S ++ N +++ D S+K+W + ++ TL E+ ++ + L Sbjct: 395 ITSIAFSE-NGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALG 453 Query: 166 SFTG-------------ISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI 204 +++ F H + S + + + Sbjct: 454 GTDVQIYICKQWTEILHFTEHSGLTTGVAFG-HHAKFIASTGMDRSLKFYSL 504 >4A11-B nrPDB Length = 408 Score = 98.8 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 33/184 (17%), Positives = 60/184 (32%), Gaps = 38/184 (20%) Query: 218 HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVP-GQLHNSSCIN 276 G T D + +GG D I ++D+ ++ T K G+ H Sbjct: 41 IHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDH------ 94 Query: 277 EIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRD-------------------LSND 317 P+ H ++ V W PH + + S+S+D T ++W +S Sbjct: 95 --PDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPV 152 Query: 318 GAKETYKTNSTDATKGSI---------FNFTQHSEFVFGADWSLWGKPGYVASTAWDGNL 368 K T K + H + + WS +A+ + D + Sbjct: 153 STKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPR-YDYILATASADSRV 211 Query: 369 FVWN 372 +W+ Sbjct: 212 KLWD 215 Score = 90.0 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 53/277 (19%), Positives = 91/277 (32%), Gaps = 50/277 (18%) Query: 103 HEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRK--QSLMTLTPRPLEITKMVDPLNAI 160 H + + + V + LS DG I ++ QS T D Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV---- 97 Query: 161 ILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFL---- 216 +R V Q+ PHD + S S + ++D + NF Sbjct: 98 ------------HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVY 145 Query: 217 VHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCIN 276 H T +VA G +++ D++ + SC + Sbjct: 146 SHHMSPVSTKHC------LVAVGTRGPKVQLCDLK-------------------SGSCSH 180 Query: 277 EIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF 336 I H I V+WSP + IL +AS D ++W G T ++ ++ Sbjct: 181 -ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 Query: 337 NFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 T H+ V G ++ G ++ + D + +WN Sbjct: 240 ANTAHNGKVNGLCFTSDG--LHLLTVGTDNRMRLWNS 274 Score = 77.6 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 51/317 (16%), Positives = 94/317 (29%), Gaps = 56/317 (17%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTF----------------KEFPIAIFKEHER 105 + L +L DG + L+D ++ P H Sbjct: 45 GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV----HRY 100 Query: 106 EVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKK 165 V + W + F SSS+D ++K+W Q T V + Sbjct: 101 SVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ------------TADVFNFEETVYSHH 148 Query: 166 SFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALT 225 +K+ LV + L L SG + H E L Sbjct: 149 MSPVSTKH--------------CLVAVGTRGPKVQL--CDLKSGSCSHILQGHR-QEILA 191 Query: 226 CDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLA 285 ++ Y++AT D+ +++WD+R + + S + AH Sbjct: 192 VSWSPRYDYILATASADSRVKLWDVRRAS----GCLITLDQHNGKKSQAVESANTAHNGK 247 Query: 286 IRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFV 345 + + ++ L++ D R+W + + Y ++ KG FT Sbjct: 248 VNGLCFTS-DGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGL--KFTVSCGCS 304 Query: 346 FGADWSLWGKPGYVAST 362 + +G V + Sbjct: 305 SEFVFVPYGSTIAVYTV 321 >4LG8-A nrPDB Length = 354 Score = 96.9 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 52/288 (18%), Positives = 102/288 (35%), Gaps = 46/288 (15%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL 121 + L S N++L D + +FD + E +A K H ++V S ++ Sbjct: 73 GILALDLCPSDTNKILTGGADKNVVVFDKSS-EQILATLKGHTKKVTSVVFHPSQD-LVF 130 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMV------DPLNAIILKKKSFTGISKNRN 175 S+S D +I+IWS + + +T + L++ + +F+ I R Sbjct: 131 SASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRV 190 Query: 176 CVY-----------QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEAL 224 AQF P + + + +S ++D++ + N NF HSG + Sbjct: 191 LTKVTDETSGCSLTCAQFHPDG-LIFGTGTMDSQIKIWDLKERT--NVANFPGHSG--PI 245 Query: 225 TCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIP----- 279 T Y +AT D+++++WD+R L ++ + + Sbjct: 246 TSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGT 305 Query: 280 ----------------NAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 H V + HH+ + S D + + + Sbjct: 306 DVQIYICKQWTEILHFTEHSGLTTGVAFG-HHAKFIASTGMDRSLKFY 352 Score = 63.4 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 44/261 (16%), Positives = 85/261 (32%), Gaps = 54/261 (20%) Query: 136 RKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSG 195 R +++ +P E++K + + L S GI C P D N +L+ Sbjct: 40 RGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLC-------PSDTNKILTGGA 92 Query: 196 NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN- 254 + +FD S + L + + F+ + +V + D IRIW + + Sbjct: 93 DKNVVVFD---KSSEQILATLKGHTKKVTSVVFHPSQD-LVFSASPDATIRIWSVPNASC 148 Query: 255 -------------KNESATIKRTVPGQLHNSSCINEIPNAH----------GLAIRKVTW 291 + AT + ++I G ++ + Sbjct: 149 VQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQF 208 Query: 292 SPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 351 P I + + D +IW ++ NF HS + +S Sbjct: 209 HP-DGLIFGTGTMDSQIKIWDLKER----------------TNVANFPGHSGPITSIAFS 251 Query: 352 LWGKPGYVASTAWDGNLFVWN 372 G Y+A+ A D ++ +W+ Sbjct: 252 ENG--YYLATAADDSSVKLWD 270 Score = 54.5 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 23/172 (13%), Positives = 56/172 (32%), Gaps = 17/172 (9%) Query: 47 RSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHERE 106 ++GR++ + T C A D ++++D + +A F H Sbjct: 186 QTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN-VANFPGHSGP 244 Query: 107 VFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT-PRPLEITKMVDPLNAIILKKK 165 + S ++ N +++ D S+K+W + ++ TL E+ ++ + L Sbjct: 245 ITSIAFSE-NGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALG 303 Query: 166 SFTG-------------ISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI 204 +++ F H + S + + + Sbjct: 304 GTDVQIYICKQWTEILHFTEHSGLTTGVAFG-HHAKFIASTGMDRSLKFYSL 354 >3JB9-L nrPDB Length = 340 Score = 94.6 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 97/296 (32%), Gaps = 53/296 (17%) Query: 96 PIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRK-QSLMTLTPRPLEITKMV 154 P H EV ++ + F S D I +W+ ++ L IT + Sbjct: 42 PNLQMFGHTAEVLVARFD-PSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQ 100 Query: 155 DPLNAIILKKKSFTGI---------------SKNRNCVYQAQFSPHDQNLVLSCSGNSYA 199 ++ ++ S + V L+ S S + Sbjct: 101 WSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTM 160 Query: 200 SLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESA 259 ++D R S L A+ + V GG+D AI+IWD+R Sbjct: 161 KVWDSR--SKDCIKTIEEKYPLTAVAI---AQQGTQVFIGGIDGAIKIWDLRN------- 208 Query: 260 TIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGA 319 + C + + H I + S S+ L+S S D T RI+ D+ + Sbjct: 209 ------------NHCSHVL-KGHKDIITSLAISKDGSS-LLSNSMDNTVRIF-DVKPFAS 253 Query: 320 KETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG 375 + A G N + G WS + +V + + D N++VW+ G Sbjct: 254 AQRQLQIFEGAIHGQEHN-------LLGVAWSRNSR--FVGAGSSDKNVYVWSATG 300 Score = 60.3 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 39/241 (16%), Positives = 72/241 (29%), Gaps = 59/241 (24%) Query: 73 ENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIW 132 + D T++++D+ K+ I +++ + DG+IKIW Sbjct: 148 SELLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIA---QQGTQVFIGGIDGAIKIW 204 Query: 133 SPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLS 192 L IT + ISK+ + +LS Sbjct: 205 DLRNNHCSHVLKGHKDIITSL---------------AISKDG-------------SSLLS 236 Query: 193 CSGNSYASLFDIRLPSGKNQNNFLV----HSGLEALTCDFN-KYRPYVVATGGVDNAIRI 247 S ++ +FD++ P Q + G E V G D + + Sbjct: 237 NSMDNTVRIFDVK-PFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYV 295 Query: 248 WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMT 307 W + + + H ++ V + PH +I++S S D T Sbjct: 296 WSA---------------------TGDLRYVLPGHEGSVNHVDFHPH-QDIILSCSSDRT 333 Query: 308 C 308 Sbjct: 334 I 334 Score = 46.8 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 35/189 (18%), Positives = 55/189 (29%), Gaps = 45/189 (23%) Query: 185 HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNA 244 D +L+ S R N + E L F+ A+GG+D Sbjct: 22 QDSSLITEGSVLQ-------RTSDLNVPNLQMFGHTAEVLVARFDP-SGSYFASGGMDRQ 73 Query: 245 IRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASY 304 I +W++ KN + N AI + WS S ++ +S Sbjct: 74 ILLWNVFGDVKN-------------------YGVLNGCKGAITDLQWS-RDSRVVYCSSS 113 Query: 305 DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAW 364 D W +S I H+ V D G + S + Sbjct: 114 DTHLMSWDAVSGQ----------------KIRKHKGHAGVVNALDVLKVGSE-LLTSVSD 156 Query: 365 DGNLFVWNG 373 D + VW+ Sbjct: 157 DCTMKVWDS 165 >5UZ7-B nrPDB Length = 351 Score = 93.8 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 65/355 (18%), Positives = 116/355 (32%), Gaps = 83/355 (23%) Query: 21 DNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQ 80 D+RL V+A + GKL I + + ++ + L + A+ S N V Sbjct: 77 DSRLLVSASQD------GKLIIWDSYTTNKVHAIP--LRSSWVMTCAYAPS-GNYVACGG 127 Query: 81 GDGTLRLFDTTFKEFPIAI---FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRK 137 D +++ +E + + H + C + N ++SS D + +W Sbjct: 128 LDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN--QIVTSSGDTTCALWD---- 181 Query: 138 QSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNS 197 I + T + + V +P D L +S + ++ Sbjct: 182 -----------------------IETGQQTTTFTGHTGDVMSLSLAP-DTRLFVSGACDA 217 Query: 198 YASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNE 257 A L+D+R G + F H + F ATG D R++D+R + Sbjct: 218 SAKLWDVR--EGMCRQTFTGHES-DINAICFFP-NGNAFATGSDDATCRLFDLRADQELM 273 Query: 258 SATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND 317 + + + G I V++S +L++ D C +W L D Sbjct: 274 TYSHDNIICG------------------ITSVSFSKSG-RLLLAGYDDFNCNVWDALKAD 314 Query: 318 GAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H V + G VA+ +WD L +WN Sbjct: 315 ----------------RAGVLAGHDNRVSCLGVTDDG--MAVATGSWDSFLKIWN 351 Score = 65.3 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 34/275 (12%), Positives = 81/275 (29%), Gaps = 71/275 (25%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 + H ++++ +W +R +S+S DG + IW + + R Sbjct: 61 TLRGHLAKIYAMHWGTDSR-LLVSASQDGKLIIWDSYTTNKVHAIPLRS----------- 108 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK-NQNNFLV 217 + V ++P + ++ S+++++ G + L Sbjct: 109 ----------------SWVMTCAYAPSGNYVAC-GGLDNICSIYNLKTREGNVRVSRELA 151 Query: 218 HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINE 277 C F + T D +WDI + + T Sbjct: 152 GHTGYLSCCRF--LDDNQIVTSSGDTTCALWDIETGQQTTTFTG---------------- 193 Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFN 337 H + ++ +P + + +S + D + ++W + Sbjct: 194 ----HTGDVMSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQT---------------- 232 Query: 338 FTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 FT H + + G A+ + D +++ Sbjct: 233 FTGHESDINAICFFPNGNAF--ATGSDDATCRLFD 265 >4V7E-Bg nrPDB Length = 380 Score = 93.4 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 46/334 (13%), Positives = 97/334 (29%), Gaps = 84/334 (25%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 + H +V+S +W +S+S DG + +W+ L Q + + + N Sbjct: 61 TLQGHSGKVYSLDWTPEKNW-IVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPN 119 Query: 159 AIILKKKSFTGI----------------------SKNRNCVYQAQFSPHDQNLVLSCSGN 196 + + ++ Q+ P + +++ SG+ Sbjct: 120 GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGD 179 Query: 197 SYASLFDIRLPSGKNQ--NNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 L+D+ + + F + L+ N + +G D +R+WD+R+ + Sbjct: 180 QTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITS 239 Query: 255 KNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDL 314 + + H I V + P + S D TCR++ Sbjct: 240 RAVRTY-------------------HGHEGDINSVKFFP-DGQRFGTGSDDGTCRLFDMR 279 Query: 315 SNDGAK---ETYKTNSTDATKGSIFNFT-------------------------------- 339 + + N + + F+ Sbjct: 280 TGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTL 339 Query: 340 --QHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 H + S G + + +WD NL +W Sbjct: 340 QNSHEGRISCLGLSSDGSA--LCTGSWDKNLKIW 371 >6EOJ-D nrPDB Length = 470 Score = 93.1 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 46/260 (17%), Positives = 98/260 (37%), Gaps = 53/260 (20%) Query: 61 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 120 + + D+A++ + + + D L++++ + + + H +V SC+W+ Sbjct: 178 ESIRDMAFSSNDS-KFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEM-GLI 234 Query: 121 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA 180 S+S D +K+W P + + I K ++ V + Sbjct: 235 ASASKDNLVKLWDPRSGNCISS---------------------------ILKFKHTVLKT 267 Query: 181 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG 240 +F P NL+++ S + +FDIR + V + +T +++ + Sbjct: 268 RFQPTKGNLLMAISKDKSCRVFDIRY---SMKELMCVRDETDYMTLEWHPINESMFTLAC 324 Query: 241 VDNAIRIWDI-RMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNIL 299 D +++ +D+ + LN I IP AH I ++++P +I Sbjct: 325 YDGSLKHFDLLQNLN------------------EPILTIPYAHDKCITSLSYNPVG-HIF 365 Query: 300 MSASYDMTCRIWRDLSNDGA 319 +A+ D T R W Sbjct: 366 ATAAKDRTIRFWTRARPIDP 385 Score = 61.5 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 42/218 (19%), Positives = 82/218 (37%), Gaps = 46/218 (21%) Query: 157 LNAIILKKKSFTGISKNR--NCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNN 214 + +I FT +S N+ + + Q++P + LV+ + + SL++ + + Sbjct: 74 RDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVV-ATYSGEFSLWNASSFTFET--- 129 Query: 215 FLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSC 274 L+ + A+T + + +G D I+IW N S Sbjct: 130 -LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP--------------------NFSM 168 Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 334 + EI AH +IR + +S + S ++ S D +IW + + Sbjct: 169 VKEIDAAHTESIRDMAFSSNDSK-FVTCSDDNILKIWNFSNGKQER-------------- 213 Query: 335 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + H V DW + G +AS + D + +W+ Sbjct: 214 --VLSGHHWDVKSCDWHP--EMGLIASASKDNLVKLWD 247 >3DM0-A nrPDB Length = 694 Score = 93.1 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 54/278 (19%), Positives = 93/278 (33%), Gaps = 69/278 (24%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 + H V + + N +S+S D SI +W K+ Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILW-------------------KLTKDDK 417 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH 218 A + ++ TG S V S Q + S S + L+D+ +G + F+ H Sbjct: 418 AYGVAQRRLTGHSHF---VEDVVLSSDGQFAL-SGSWDGELRLWDLA--AGVSTRRFVGH 471 Query: 219 SGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 + L+ F + + D I++W+ C I Sbjct: 472 -TKDVLSVAF-SLDNRQIVSASRDRTIKLWN--------------------TLGECKYTI 509 Query: 279 P---NAHGLAIRKVTWSPHH-SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 334 H + V +SP+ ++SAS+D T ++W +LSN + T Sbjct: 510 SEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVW-NLSNCKLRSTL----------- 557 Query: 335 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H+ +V S G AS DG + +W+ Sbjct: 558 ----AGHTGYVSTVAVSPDGS--LCASGGKDGVVLLWD 589 Score = 79.2 bits (193), Expect = 2e-15, Method: Composition-based stats. Identities = 47/248 (18%), Positives = 84/248 (33%), Gaps = 47/248 (18%) Query: 72 HENQVLVAQGDGTLRLFDTTFKEFPIAIF---KEHEREVFSCNWNLV-NRQNFLSSSWDG 127 Q++ A D T++L++ T E I + H V ++ + +S+SWD Sbjct: 483 DNRQIVSASRDRTIKLWN-TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDK 541 Query: 128 SIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQ 187 ++K+W+ + TL + + V SP Sbjct: 542 TVKVWNLSNCKLRSTL---------------------------AGHTGYVSTVAVSPDG- 573 Query: 188 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 247 +L S + L+D+ GK + +S + AL F+ ++ I+I Sbjct: 574 SLCASGGKDGVVLLWDLA--EGKKLYSLEANSVIHALC--FSP--NRYWLCAATEHGIKI 627 Query: 248 WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAI---RKVTWSPHHSNILMSASY 304 WD+ + E V + N P A + + WS S + S Sbjct: 628 WDLESKSIVEDLK----VDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLF-SGYT 682 Query: 305 DMTCRIWR 312 D R+W Sbjct: 683 DGVIRVWG 690 Score = 68.0 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 74/244 (30%), Gaps = 39/244 (15%) Query: 132 WSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 191 W +R + + R + + + + V + ++++ Sbjct: 340 WYAVRTAVINAASGRQTVDAALAAAQTNAAAGLVLKGTMRAHTDMVTAIATPIDNADIIV 399 Query: 192 SCSGNSYASLFDI---RLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 S S + L+ + G Q HS +G D +R+W Sbjct: 400 SASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVL--SSDGQFALSGSWDGELRLW 457 Query: 249 DIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTC 308 D+ + +R V H + V +S + I +SAS D T Sbjct: 458 DL-----AAGVSTRRFV---------------GHTKDVLSVAFSLDNRQI-VSASRDRTI 496 Query: 309 RIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNL 368 ++W L E T S H ++V +S + S +WD + Sbjct: 497 KLWNTLG-----ECKYTISEGG--------EGHRDWVSCVRFSPNTLQPTIVSASWDKTV 543 Query: 369 FVWN 372 VWN Sbjct: 544 KVWN 547 Score = 59.2 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 24/194 (12%), Positives = 71/194 (36%), Gaps = 22/194 (11%) Query: 60 QDCLFDLAWNES-HENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQ 118 +D + + ++ + + ++ A D T+++++ + + + H V + + Sbjct: 517 RDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLR-STLAGHTGYVSTVAVSPD-GS 574 Query: 119 NFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVY 178 S DG + +W + L +L + ++A+ + + + + Sbjct: 575 LCASGGKDGVVLLWDLAEGKKLYSLEANSV--------IHALCFSPNRYWLCAATEHGIK 626 Query: 179 QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYR--PYVV 236 + +++V + D++ + K N+ + + + C + + Sbjct: 627 --IWDLESKSIV------EDLKV-DLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTL 677 Query: 237 ATGGVDNAIRIWDI 250 +G D IR+W I Sbjct: 678 FSGYTDGVIRVWGI 691 >3JRO-A nrPDB Length = 753 Score = 92.7 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 56/339 (16%), Positives = 102/339 (30%), Gaps = 77/339 (22%) Query: 51 IVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIA-IFKEHEREVFS 109 I ++ L D + D + ++ D T+++F+ + + HE V+ Sbjct: 4 IANAHNELIHDAVLDY-----YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 58 Query: 110 CNW-NLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT 168 +W + S S+DG + IW + Sbjct: 59 VDWAHPKFGTILASCSYDGKVLIWKEENG-------------------------RWSQIA 93 Query: 169 GISKNRNCVYQAQFSPHD-QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCD 227 + + V Q++PH+ L+L S + S+ + + G + + + Sbjct: 94 VHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKEN-GTTSPIIIDAHAIGVNSAS 152 Query: 228 FNK------------YRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 + TGG DN ++IW + + Sbjct: 153 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK----------------YNSDAQTYVL 196 Query: 276 NEIPNAHGLAIRKVTWSPHH--SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKG 333 H +R V WSP + L S S D TC IW + G + Sbjct: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 256 Query: 334 SIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 ++ A WSL G +A + D + +W Sbjct: 257 -----------LWRASWSLSGN--VLALSGGDNKVTLWK 282 Score = 46.4 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 72/232 (31%), Gaps = 44/232 (18%) Query: 37 NGKLFILEIDRSGRIVEVNSFLTQDCLFD-LAWNESH-ENQVLVAQGDGTLRL--FDTTF 92 +GK+ I + + +GR ++ + + W +LVA DG + + F Sbjct: 76 DGKVLIWK-EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 Query: 93 KEFPIAIFKEHEREVFSCNWNLV------------NRQNFLSSSWDGSIKIWSPLRKQSL 140 PI I H V S +W + F++ D +KIW Sbjct: 135 TTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 193 Query: 141 MTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP--HDQNLVLSCSGNSY 198 L + + + + V +SP ++ + S S + Sbjct: 194 YVLE-----------------------STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 Query: 199 ASLFDIRLPSGKNQNNFLVHSGLEALTCDFN-KYRPYVVATGGVDNAIRIWD 249 ++ G + L + + V+A G DN + +W Sbjct: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 >4YCZ-A nrPDB Length = 876 Score = 91.1 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 60/334 (17%), Positives = 107/334 (32%), Gaps = 78/334 (23%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTT-FKEFPIAIFKEHEREVFSCNW-NLVNR 117 D + A + + ++ D T+++F+ + K H+ V+ +W + Sbjct: 17 HDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYG 76 Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 177 S+ +DG + IW L + + ++ V Sbjct: 77 NILASAGYDGKVLIWRELNG-------------------------AWQRIFDFALHKASV 111 Query: 178 YQAQFSPHDQN-LVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNK------ 230 +SPH+ L+ S + S+ + R S + ++ GL + + Sbjct: 112 NVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWE--HSIFHAHGLGVNSVSWAPATSPGS 169 Query: 231 ----------YRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPN 280 TGG DNA++IW + E Sbjct: 170 IVSSKPGPKSTGNRRFVTGGSDNALKIW---------------AYDPATNTYKLEREPLT 214 Query: 281 AHGLAIRKVTWSPH--HSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNF 338 H +R V WSP + + SAS D T RIW + + K + DA Sbjct: 215 GHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAA------- 267 Query: 339 TQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 V+ WSL G +A++ D + +W Sbjct: 268 ------VWRVSWSLSGN--VLAASGGDNKVTLWK 293 Score = 31.0 bits (68), Expect = 0.83, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 29/94 (30%), Gaps = 15/94 (15%) Query: 281 AHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQ 340 H I ++ L + S D T +I+ T+ Sbjct: 16 GHDDMIHDAVLD-YYGRRLATCSSDRTIKIF--------------EIEGETQRLTETLKG 60 Query: 341 HSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGL 374 H V+ W+ +AS +DG + +W L Sbjct: 61 HDGAVWCVSWAHPKYGNILASAGYDGKVLIWREL 94 >5NZU-C nrPDB Length = 905 Score = 90.4 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 37/290 (12%), Positives = 83/290 (28%), Gaps = 58/290 (20%) Query: 100 FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT------------PRP 147 V S + + S ++GS+ +W+ + + T R Sbjct: 11 LTARSDRVKSVDLHPTEPWMLAS-LYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK 69 Query: 148 LEITKMVDPLNAIILKKKSFTGI---SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI 204 + D + + + + + + + P Q +L+ S + L+D Sbjct: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHP-TQPFILTSSDDMLIKLWDW 128 Query: 205 RLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRT 264 F H+ + N A+ +D I++W + Sbjct: 129 D-KKWSCSQVFEGHTHY-VMQIVINPKDNNQFASASLDRTIKVWQL-------------- 172 Query: 265 VPGQLHNSSCINEIPNAHGLAIRKVTWSPH-HSNILMSASYDMTCRIWRDLSNDGAKETY 323 SS N H + + + L+S + D +IW + + Sbjct: 173 ------GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTL- 225 Query: 324 KTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 H++ V A + + + + + DG + +W+ Sbjct: 226 ---------------EGHAQNVSCASFHP--ELPIIITGSEDGTVRIWHS 258 Score = 83.0 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 34/178 (19%), Positives = 61/178 (34%), Gaps = 30/178 (16%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 + +L + D ++L+D K +F+ H V N + F S+S D +IK Sbjct: 109 PTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIK 168 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 190 +W TL K NC+ +S D+ + Sbjct: 169 VWQLGSSSPNFTLEGHE------------------------KGVNCID--YYSGGDKPYL 202 Query: 191 LSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 +S + + ++D + + H F+ P ++ TG D +RIW Sbjct: 203 ISGADDRLVKIWDYQNKT--CVQTLEGH-AQNVSCASFHPELP-IIITGSEDGTVRIW 256 >6ID0-T nrPDB Length = 514 Score = 90.4 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 53/295 (17%), Positives = 95/295 (32%), Gaps = 74/295 (25%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPR------------ 146 + H V N+ F++ S D +IKIW + ++LT Sbjct: 199 VISGHLGWVRCIAVEPGNQW-FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257 Query: 147 -PLEITKMVDP--------LNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNS 197 P + D N +I + + VY P +++++CS +S Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYH------GHLSAVYGLDLHP-TIDVLVTCSRDS 310 Query: 198 YASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNE 257 A ++D+R + + H+ T P ++ TG D IR+WD+ Sbjct: 311 TARIWDVRTKAS--VHTLSGHTNA-VATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTRV 366 Query: 258 SATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND 317 + T H ++R V P H S S D + W+ Sbjct: 367 TLTN--------------------HKKSVRAVVLHPRHYT-FASGSPDN-IKQWKFPDG- 403 Query: 318 GAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 I N + H+ + + G + S A +G + +W+ Sbjct: 404 ---------------SFIQNLSGHNAIINTLTVNSDG---VLVSGADNGTMHLWD 440 Score = 75.3 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 43/277 (15%), Positives = 88/277 (31%), Gaps = 55/277 (19%) Query: 52 VEVNSFLTQ-----DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHERE 106 +E N + ++ L + + + ++ D T R++D K + H Sbjct: 275 LEYNKVIRHYHGHLSAVYGLDLHPTI-DVLVTCSRDSTARIWDVRTK-ASVHTLSGHTNA 332 Query: 107 VFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKS 166 V + Q ++ S D +I++W + ++ +TLT Sbjct: 333 VATVRCQAAEPQ-IITGSHDTTIRLWDLVAGKTRVTLT---------------------- 369 Query: 167 FTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTC 226 ++ V P S S ++ + + P G N H+ + T Sbjct: 370 -----NHKKSVRAVVLHPRH-YTFASGSPDN-IKQW--KFPDGSFIQNLSGHNAI-INTL 419 Query: 227 DFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAI 286 N V+ +G + + +WD R N PG L + I Sbjct: 420 TVN--SDGVLVSGADNGTMHLWDWRTGY-NFQRVHAAVQPGSLDS-----------ESGI 465 Query: 287 RKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETY 323 + + L++A D T +++R+ + Sbjct: 466 FACAFD-QSESRLLTAEADKTIKVYREDDTATEETHP 501 >5GAN-H nrPDB Length = 465 Score = 88.4 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 59/323 (18%), Positives = 108/323 (33%), Gaps = 61/323 (18%) Query: 70 ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 + + V G L++ ++ + H ++ + +W+ + +S + DG I Sbjct: 184 STDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLI 243 Query: 130 KIWSPLRKQ----SLMTLTPRPLEITKMVDPLNAIILKKKSFTGI--------------- 170 K + ++ L L I+ + + + S Sbjct: 244 KNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQ 303 Query: 171 SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNK 230 + V+ F D +LV S +S + L+DIR SG HS T ++ Sbjct: 304 EGHDKGVFSLSF-QCDGSLVCSGGMDSLSMLWDIR--SGSKVMTLAGHSK-PIYTVAWSP 359 Query: 231 YRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVT 290 Y VATGG D I +WDIR ++ + I AH + +V Sbjct: 360 -NGYQVATGGGDGIINVWDIRKRDEGQLNQIL------------------AHRNIVTQVR 400 Query: 291 WSPHHSN-ILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGAD 349 +S L+S YD ++ + H++ + D Sbjct: 401 FSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLA----------------GHTDKIISLD 444 Query: 350 WSLWGKPGYVASTAWDGNLFVWN 372 S ++ S WD ++ +WN Sbjct: 445 ISNNSH--FLVSGGWDRSIKLWN 465 >6N9G-C nrPDB Length = 353 Score = 88.0 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 53/343 (15%), Positives = 104/343 (30%), Gaps = 81/343 (23%) Query: 42 ILEIDRSGRIVEVNSF-------LTQDCLFDLAWNESHENQVLVAQG-DGTLRLFDTTFK 93 I+ + G+++ +SF +T C + +A + + G D ++ TF Sbjct: 78 IVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFD 137 Query: 94 EFPIA-----IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPL 148 + H + +C++ + L++S DG+ +W Q L + Sbjct: 138 KNENMAAKKKSVAMHTNYLSACSF-TNSDMQILTASGDGTCALWDVESGQLLQSFHGHGA 196 Query: 149 EITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPS 208 ++ + + N +S + A ++D+R S Sbjct: 197 DVLCLDLAPSETG--------------------------NTFVSGGCDKKAMVWDMR--S 228 Query: 209 GKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQ 268 G+ F H + + + A+G D R++D+R + + + + G Sbjct: 229 GQCVQAFETHES-DVNSVRYYP-SGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGA 286 Query: 269 LHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNST 328 V +S +L + D T +W L Sbjct: 287 ------------------SSVDFS-LSGRLLFAGYNDYTINVWDVLKG------------ 315 Query: 329 DATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 + H V S G S +WD L VW Sbjct: 316 ----SRVSILFGHENRVSTLRVSPDGTAF--CSGSWDHTLRVW 352 Score = 51.4 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 64/201 (31%), Gaps = 36/201 (17%) Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKY 231 + N V + D+ ++S S + ++D + + + + + C + Sbjct: 61 GHGNKVLCMDWC-KDKRRIVSSSQDGKVIVWDSFTTNKE---HAVTMPCTWVMACAYAP- 115 Query: 232 RPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTW 291 +A GG+DN ++ + A K++V H + ++ Sbjct: 116 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAM--------------HTNYLSACSF 161 Query: 292 SPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 351 + IL +AS D TC +W S + +F H V D + Sbjct: 162 TNSDMQIL-TASGDGTCALWDVESGQ----------------LLQSFHGHGADVLCLDLA 204 Query: 352 LWGKPGYVASTAWDGNLFVWN 372 S D VW+ Sbjct: 205 PSETGNTFVSGGCDKKAMVWD 225 >2HES-X nrPDB Length = 330 Score = 88.0 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 46/317 (14%), Positives = 104/317 (32%), Gaps = 59/317 (18%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLF------DTTFKEFPIAIFKEHEREVFSCNWNLVN 116 + +AW H + + D T+ ++ D TF+ +AI + HE EV W+ Sbjct: 61 IRSVAW-RPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSND- 118 Query: 117 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNC 176 + S D S+ IW + + + + + ++ Sbjct: 119 GYYLATCSRDKSVWIWET-----------------------DESGEEYECISVLQEHSQD 155 Query: 177 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRP-YV 235 V + P + L+ S S + ++ + H G + DF+K + Sbjct: 156 VKHVIWHP-SEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGT-VWSSDFDKTEGVFR 213 Query: 236 VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 295 + +G D+ +R+W ++++ C +P+ H + V W + Sbjct: 214 LCSGSDDSTVRVWKYMGDDEDDQQEWV-----------CEAILPDVHKRQVYNVAWGFNG 262 Query: 296 SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGK 355 ++ S D ++ ++ + + + ++ W Sbjct: 263 --LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVK------------WLELNG 308 Query: 356 PGYVASTAWDGNLFVWN 372 +A+ DG + W+ Sbjct: 309 KTILATGGDDGIVNFWS 325 Score = 73.8 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 50/287 (17%), Positives = 97/287 (33%), Gaps = 71/287 (24%) Query: 97 IAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDP 156 I K ++ +++S +++ + S D IK+ Sbjct: 7 IKSLKLYKEKIWSFDFSQ---GILATGSTDRKIKL------------------------- 38 Query: 157 LNAIILKKKSFTGI-----SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK- 210 + +K FT I + ++ + + PH +L+ + S +S S++ + + Sbjct: 39 ---VSVKYDDFTLIDVLDETAHKKAIRSVAWRPH-TSLLAAGSFDSTVSIWAKEESADRT 94 Query: 211 -NQNNFLVHSGLE-ALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQ 268 + + G E + Y +AT D ++ IW+ Sbjct: 95 FEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWE---------------TDES 139 Query: 269 LHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNST 328 CI+ + H ++ V W P +L S+SYD T RIW+D Sbjct: 140 GEEYECISVLQE-HSQDVKHVIWHP-SEALLASSSYDDTVRIWKDY-------------- 183 Query: 329 DATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG 375 D + H V+ +D+ + S + D + VW +G Sbjct: 184 DDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMG 230 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 43/305 (14%), Positives = 93/305 (30%), Gaps = 54/305 (17%) Query: 72 HENQVLVAQGDGTLRLFDTTFKEFPIAIF---KEHEREVFSCNWNLVNRQNFLSSSWDGS 128 + + D ++L + +F + H++ + S W + + S+D + Sbjct: 23 SQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWR-PHTSLLAAGSFDST 81 Query: 129 IKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQN 188 + IW+ + I + N V +S +D Sbjct: 82 VSIWAKEESADRT--------------------FEMDLLAIIEGHENEVKGVAWS-NDGY 120 Query: 189 LVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 + +CS + +++ + + ++ + + ++A+ D+ +RIW Sbjct: 121 YLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIW 180 Query: 249 DIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNI-LMSASYDMT 307 + C+ + N H + + L S S D T Sbjct: 181 K-----------------DYDDDWECV-AVLNGHEGTVWSSDFDKTEGVFRLCSGSDDST 222 Query: 308 CRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGN 367 R+W+ + D + + H V+ W G +AS DG Sbjct: 223 VRVWKYM-GDDEDDQQEWVCEAILPDV------HKRQVYNVAWGFNG---LIASVGADGV 272 Query: 368 LFVWN 372 L V+ Sbjct: 273 LAVYE 277 Score = 51.1 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 31/222 (13%), Positives = 75/222 (33%), Gaps = 37/222 (16%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFP---IAIFKEHEREVFSCNWNLVNRQN 119 + +AW+ + + D ++ +++T I++ +EH ++V W+ + Sbjct: 110 VKGVAWS-NDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWH-PSEAL 167 Query: 120 FLSSSWDGSIKIWSPLRK--QSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISK----- 172 SSS+D +++IW + + L + + + S + S Sbjct: 168 LASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWK 227 Query: 173 ---------------------NRNCVYQAQFSPHDQNLVLSCSGNSYASLFD-IRLPSGK 210 ++ VY + + L+ S + ++++ + Sbjct: 228 YMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG--LIASVGADGVLAVYEEVDGEWKV 285 Query: 211 NQNNFLVHSGLEALTCDFNKYRP-YVVATGGVDNAIRIWDIR 251 L H E + + ++ATGG D + W + Sbjct: 286 FAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLE 327 >3JRP-A nrPDB Length = 379 Score = 87.3 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 56/339 (16%), Positives = 102/339 (30%), Gaps = 77/339 (22%) Query: 51 IVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIA-IFKEHEREVFS 109 I ++ L D + D + ++ D T+++F+ + + HE V+ Sbjct: 6 IANAHNELIHDAVLDY-----YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 110 CNW-NLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT 168 +W + S S+DG + IW + Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENG-------------------------RWSQIA 95 Query: 169 GISKNRNCVYQAQFSPHD-QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCD 227 + + V Q++PH+ L+L S + S+ + + G + + + Sbjct: 96 VHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKEN-GTTSPIIIDAHAIGVNSAS 154 Query: 228 FNK------------YRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 + TGG DN ++IW + + Sbjct: 155 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK----------------YNSDAQTYVL 198 Query: 276 NEIPNAHGLAIRKVTWSPHH--SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKG 333 H +R V WSP + L S S D TC IW + G + Sbjct: 199 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 258 Query: 334 SIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 ++ A WSL G +A + D + +W Sbjct: 259 -----------LWRASWSLSGN--VLALSGGDNKVTLWK 284 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 72/232 (31%), Gaps = 44/232 (18%) Query: 37 NGKLFILEIDRSGRIVEVNSFLTQDCLFD-LAWNESH-ENQVLVAQGDGTLRL--FDTTF 92 +GK+ I + + +GR ++ + + W +LVA DG + + F Sbjct: 78 DGKVLIWK-EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 136 Query: 93 KEFPIAIFKEHEREVFSCNWNLV------------NRQNFLSSSWDGSIKIWSPLRKQSL 140 PI I H V S +W + F++ D +KIW Sbjct: 137 TTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 195 Query: 141 MTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP--HDQNLVLSCSGNSY 198 L + + + + V +SP ++ + S S + Sbjct: 196 YVLE-----------------------STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 232 Query: 199 ASLFDIRLPSGKNQNNFLVHSGLEALTCDFN-KYRPYVVATGGVDNAIRIWD 249 ++ G + L + + V+A G DN + +W Sbjct: 233 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 284 >4V6W-Ag nrPDB Length = 318 Score = 86.5 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 50/331 (15%), Positives = 107/331 (32%), Gaps = 59/331 (17%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEF-----PIAIFKEHEREVFSCNWNLVNR 117 + +A N + ++ A D TL ++ T E P H + + Sbjct: 18 VTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSD-G 76 Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGI------- 170 LS SWD ++++W ++ ++ + + + S Sbjct: 77 NYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL 136 Query: 171 ---------SKNRNCVYQAQFSPHDQN-LVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG 220 + + V +FSP+ N +++SC + ++++ K NN H+G Sbjct: 137 AECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLK--NNHHGHNG 194 Query: 221 LEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPN 280 T + + +GG D+ +WD+ ++ + + Sbjct: 195 YL-NTVTVSP-DGSLCTSGGKDSKALLWDL-------------------NDGKNLYTLE- 232 Query: 281 AHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQ 340 H I + +SP + + +Y + +IW +E + +K Sbjct: 233 -HNDIINALCFSP--NRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKA------- 282 Query: 341 HSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 WS G+ + + D + VW Sbjct: 283 DQPQCLSLAWSTDGQTLF--AGYSDNTIRVW 311 Score = 81.9 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 85/275 (30%), Gaps = 64/275 (23%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 H V N + +S+S D ++ +W R D Sbjct: 10 TLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTR------------------DEDT 51 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH 218 +K G S + S + S S + L+D+ +GK F H Sbjct: 52 NYGYPQKRLYGHSHF---ISDVVLSSDGNYAL-SGSWDQTLRLWDLA--AGKTTRRFEGH 105 Query: 219 SGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 + L+ F+ + +G D I++W N A K T+ Sbjct: 106 -TKDVLSVAFSA-DNRQIVSGSRDKTIKLW-------NTLAECKFTIQ------------ 144 Query: 279 PNAHGLAIRKVTWSPHHS-NILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFN 337 + H + V +SP+HS I++S +D T ++W + N Sbjct: 145 EDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCK----------------LKNN 188 Query: 338 FTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H+ ++ S G S D +W+ Sbjct: 189 HHGHNGYLNTVTVSPDGS--LCTSGGKDSKALLWD 221 Score = 61.1 bits (146), Expect = 7e-10, Method: Composition-based stats. Identities = 48/246 (19%), Positives = 76/246 (30%), Gaps = 70/246 (28%) Query: 70 ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 S N L D TLRL+D + F+ H ++V S ++ NRQ +S S D +I Sbjct: 73 SSDGNYALSGSWDQTLRLWDLAAGKT-TRRFEGHTKDVLSVAFSADNRQ-IVSGSRDKTI 130 Query: 130 KIWSPLRKQSLMTLTPR----------------PLEITKMVDPLNAI--ILKKKSFTGIS 171 K+W+ L + P+ ++ D + + K Sbjct: 131 KLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHH 190 Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKY 231 + + SP +L S +S A L+D L GKN + + AL N+Y Sbjct: 191 GHNGYLNTVTVSPDG-SLCTSGGKDSKALLWD--LNDGKNLYTLEHNDIINALCFSPNRY 247 Query: 232 -----------------------------------------------RPYVVATGGVDNA 244 + G DN Sbjct: 248 WLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNT 307 Query: 245 IRIWDI 250 IR+W + Sbjct: 308 IRVWQV 313 Score = 57.2 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 47/148 (31%), Gaps = 35/148 (23%) Query: 229 NKYRPYVVATGGVDNAIRIWDI-RMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIR 287 N P + + D + +W + R + N KR H I Sbjct: 24 NPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY---------------GHSHFIS 68 Query: 288 KVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFG 347 V S N +S S+D T R+W + + F H++ V Sbjct: 69 DVVLSS-DGNYALSGSWDQTLRLWDLAAGKTTRR----------------FEGHTKDVLS 111 Query: 348 ADWSLWGKPGYVASTAWDGNLFVWNGLG 375 +S + + S + D + +WN L Sbjct: 112 VAFSADNRQ--IVSGSRDKTIKLWNTLA 137 >6G51-g nrPDB Length = 317 Score = 85.7 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 50/276 (18%), Positives = 90/276 (32%), Gaps = 67/276 (24%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 K H V LS+S D +I +W R ++ + R L Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL---------- 59 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH 218 + + + QF+ S S + L+D L +G F+ H Sbjct: 60 ------RGHSHFVSDVVISSDGQFAL-------SGSWDGTLRLWD--LTTGTTTRRFVGH 104 Query: 219 SGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 + L+ F+ + +G D I++W+ C + Sbjct: 105 -TKDVLSVAFSS-DNRQIVSGSRDKTIKLWN--------------------TLGVCKYTV 142 Query: 279 PN-AHGLAIRKVTWSPHHS-NILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF 336 + +H + V +SP+ S I++S +D ++W +L+N K Sbjct: 143 QDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW-NLANCKLKT--------------- 186 Query: 337 NFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 N H+ ++ S G AS DG +W+ Sbjct: 187 NHIGHTGYLNTVTVSPDGS--LCASGGKDGQAMLWD 220 Score = 85.7 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 102/303 (33%), Gaps = 65/303 (21%) Query: 70 ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 S L DGTLRL+D T F H ++V S ++ NRQ +S S D +I Sbjct: 72 SSDGQFALSGSWDGTLRLWDLTTGTT-TRRFVGHTKDVLSVAFSSDNRQ-IVSGSRDKTI 129 Query: 130 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQN- 188 K+W+ L T+ V +FSP+ N Sbjct: 130 KLWNTL-GVCKYTVQDESHSEW-------------------------VSCVRFSPNSSNP 163 Query: 189 LVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 +++SC + ++++ K N + H+G T + + A+GG D +W Sbjct: 164 IIVSCGWDKLVKVWNLANCKLK--TNHIGHTGYL-NTVTVSP-DGSLCASGGKDGQAMLW 219 Query: 249 DIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTC 308 D+ + + + I + +SP + + A+ + Sbjct: 220 DL-------------------NEGKHLYTLDGG--DIINALCFSP--NRYWLCAATGPSI 256 Query: 309 RIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNL 368 +IW E + + ++K WS G+ + + D + Sbjct: 257 KIWDLEGKIIVDELKQEVISTSSKA-------EPPQCTSLAWSADGQTLF--AGYTDNLV 307 Query: 369 FVW 371 VW Sbjct: 308 RVW 310 Score = 55.7 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 24/146 (16%), Positives = 44/146 (30%), Gaps = 34/146 (23%) Query: 230 KYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKV 289 P ++ + D I +W + N + H + V Sbjct: 25 PQFPDMILSASRDKTIIMWKLTRDETNYGIPQRAL---------------RGHSHFVSDV 69 Query: 290 TWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGAD 349 S +S S+D T R+W + + F H++ V Sbjct: 70 VISS-DGQFALSGSWDGTLRLWDLTTGTTTRR----------------FVGHTKDVLSVA 112 Query: 350 WSLWGKPGYVASTAWDGNLFVWNGLG 375 +S + + S + D + +WN LG Sbjct: 113 FSSDNRQ--IVSGSRDKTIKLWNTLG 136 Score = 48.4 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 21/98 (21%), Positives = 37/98 (37%), Gaps = 13/98 (13%) Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 334 + H + ++ +P ++++SAS D T +W+ T Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL-----------TRDETNYGIP 55 Query: 335 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 HS FV S G+ + S +WDG L +W+ Sbjct: 56 QRALRGHSHFVSDVVISSDGQ--FALSGSWDGTLRLWD 91 >3MKQ-A nrPDB Length = 814 Score = 85.3 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 54/326 (16%), Positives = 100/326 (30%), Gaps = 67/326 (20%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 + VL D T++L++ F+ HE V +N + F S D ++K Sbjct: 107 PTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVK 166 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 190 +WS + TLT VD D+ + Sbjct: 167 VWSLGQSTPNFTLTTGQERGVNYVDYYP-------------------------LPDKPYM 201 Query: 191 LSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI 250 ++ S + ++D + H + F+ P ++ +G D ++IW+ Sbjct: 202 ITASDDLTIKIWD--YQTKSCVATLEGHMSNVSFAV-FHPTLP-IIISGSEDGTLKIWN- 256 Query: 251 RMLNKNESATIKRTVPGQLHNSSCINEIPNAHG-------------------------LA 285 + + +++T+ L S CI P Sbjct: 257 -----SSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDP 311 Query: 286 IRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGA--KETYKTNSTDATKGSIFNFTQHSE 343 + K+ WS N S + R ++ D +T + S D S+ + + Sbjct: 312 VGKLVWSG-GKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSL-AHSPNGR 369 Query: 344 FVFGADWSLWGKPGYVASTAWDGNLF 369 FV G+ + AW F Sbjct: 370 FVTVVG---DGEYVIYTALAWRNKAF 392 Score = 83.8 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 62/342 (18%), Positives = 110/342 (32%), Gaps = 88/342 (25%) Query: 41 FILEIDRSGRI--------VEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTF 92 ++L SGR+ VEV S + + +N ++V D +R+F+ Sbjct: 27 WVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNT 86 Query: 93 KEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITK 152 E + F+ H + S + LS S D ++K+W+ +L Sbjct: 87 GEK-VVDFEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNWENNWAL------------ 132 Query: 153 MVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQ 212 +++F G CV F+P D + S + ++ + G++ Sbjct: 133 -----------EQTFEGHEHFVMCV---AFNPKDPSTFASGCLDRTVKVWSL----GQST 174 Query: 213 NNFLVHSGLE--ALTCDFNKYRPY-VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQL 269 NF + +G E D+ + T D I+IWD + Sbjct: 175 PNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQ------------------ 216 Query: 270 HNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTD 329 SC+ + H + + P I++S S D T +IW + K Sbjct: 217 -TKSCVATLE-GHMSNVSFAVFHPT-LPIIISGSEDGTLKIWNSSTYKVEKTLNVG---- 269 Query: 330 ATKGSIFNFTQHSEFVFGADWS----LWGKPGYVASTAWDGN 367 W G+ Y+AS +G Sbjct: 270 ----------------LERSWCIATHPTGRKNYIASGFDNGF 295 Score = 63.4 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 90/305 (29%), Gaps = 83/305 (27%) Query: 98 AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPL 157 F V +++ L++ + G ++IW+ + R +++T+ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPW-VLTTLYSGRVEIWNYET-----QVEVRSIQVTETPVRA 60 Query: 158 NAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLV 217 I +K N ++ S + +F+ +G+ +F Sbjct: 61 GKFIARK-----------------------NWIIVGSDDFRIRVFN--YNTGEKVVDFE- 94 Query: 218 HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINE 277 + + +PYV+ +G D +++W+ + + + Sbjct: 95 AHPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWEN-------------------NWALEQ 134 Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR---------------------DLSN 316 H + V ++P + S D T ++W D Sbjct: 135 TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYP 194 Query: 317 DGAKETYKTNSTD--------ATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNL 368 K T S D TK + H V A + + S + DG L Sbjct: 195 LPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHP--TLPIIISGSEDGTL 252 Query: 369 FVWNG 373 +WN Sbjct: 253 KIWNS 257 >4BZK-B nrPDB Length = 297 Score = 85.3 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 56/339 (16%), Positives = 102/339 (30%), Gaps = 77/339 (22%) Query: 51 IVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIA-IFKEHEREVFS 109 I ++ L D + D + ++ D T+++F+ + + HE V+ Sbjct: 4 IANAHNELIHDAVLDY-----YGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 58 Query: 110 CNW-NLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT 168 +W + S S+DG + IW + Sbjct: 59 VDWAHPKFGTILASCSYDGKVLIWKEENG-------------------------RWSQIA 93 Query: 169 GISKNRNCVYQAQFSPHD-QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCD 227 + + V Q++PH+ L+L S + S+ + + G + + + Sbjct: 94 VHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKEN-GTTSPIIIDAHAIGVNSAS 152 Query: 228 FNK------------YRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 + TGG DN ++IW + + Sbjct: 153 WAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK----------------YNSDAQTYVL 196 Query: 276 NEIPNAHGLAIRKVTWSPHH--SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKG 333 H +R V WSP + L S S D TC IW + G + Sbjct: 197 ESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDV 256 Query: 334 SIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 ++ A WSL G +A + D + +W Sbjct: 257 -----------LWRASWSLSGN--VLALSGGDNKVTLWK 282 Score = 42.2 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 72/232 (31%), Gaps = 44/232 (18%) Query: 37 NGKLFILEIDRSGRIVEVNSFLTQDCLFD-LAWNESH-ENQVLVAQGDGTLRL--FDTTF 92 +GK+ I + + +GR ++ + + W +LVA DG + + F Sbjct: 76 DGKVLIWK-EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENG 134 Query: 93 KEFPIAIFKEHEREVFSCNWNLV------------NRQNFLSSSWDGSIKIWSPLRKQSL 140 PI I H V S +W + F++ D +KIW Sbjct: 135 TTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 193 Query: 141 MTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP--HDQNLVLSCSGNSY 198 L + + + + V +SP ++ + S S + Sbjct: 194 YVLE-----------------------STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 Query: 199 ASLFDIRLPSGKNQNNFLVHSGLEALTCDFN-KYRPYVVATGGVDNAIRIWD 249 ++ G + L + + V+A G DN + +W Sbjct: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 >4V8M-A7 nrPDB Length = 318 Score = 84.2 bits (206), Expect = 8e-17, Method: Composition-based stats. Identities = 50/347 (14%), Positives = 91/347 (26%), Gaps = 96/347 (27%) Query: 66 LAWNESHENQVLVAQGDGTLRLFDTTFKEF--------PIAIFKEHEREVFSCNWNLVNR 117 +V+ D TL + P + H V N Sbjct: 21 CPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVAL-SNNG 79 Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 177 +S+SWD S+++W+ Q + V Sbjct: 80 NFAVSASWDHSLRLWNLQNGQCQYKFLGHTKD---------------------------V 112 Query: 178 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFL-VHSGLEALTCDFNK-YRPYV 235 FSP ++ ++S ++ ++++ G+ + F+ V Sbjct: 113 LSVAFSPDNRQ-IVSGGRDNALRVWNV---KGECMHTLSRGAHTDWVSCVRFSPSLDAPV 168 Query: 236 VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 295 + +GG DN +++WD+ + + H + VT SP Sbjct: 169 IVSGGWDNLVKVWDL--------------------ATGRLVTDLKGHTNYVTSVTVSPDG 208 Query: 296 SNILMSASYDMTCRIWRDLSNDGAKET----------------------------YKTNS 327 S + S+ D R+W + E + + Sbjct: 209 S-LCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLEN 267 Query: 328 TDATKGSIFNFTQHSEFVFGA---DWSLWGKPGYVASTAWDGNLFVW 371 D + V WS G Y S D + VW Sbjct: 268 KDIIVELAPEHQGSKKIVPECVSIAWSADGSTLY--SGYTDNVIRVW 312 Score = 73.8 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 96/275 (34%), Gaps = 61/275 (22%) Query: 70 ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 ++ N + A D +LRL++ + F H ++V S ++ NRQ +S D ++ Sbjct: 76 SNNGNFAVSASWDHSLRLWNLQNGQC-QYKFLGHTKDVLSVAFSPDNRQ-IVSGGRDNAL 133 Query: 130 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP-HDQN 188 ++W+ ++ + + TL+ + + V +FSP D Sbjct: 134 RVWN-VKGECMHTLSRG-------------------------AHTDWVSCVRFSPSLDAP 167 Query: 189 LVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 +++S ++ ++D+ +G+ + H+ + + + A+ D R+W Sbjct: 168 VIVSGGWDNLVKVWDLA--TGRLVTDLKGHTNY-VTSVTVSP-DGSLCASSDKDGVARLW 223 Query: 249 DIR---------------------MLNKNESATIKRTVPGQLHNSSCINEIPNAHGL--- 284 D+ +AT K L N I E+ H Sbjct: 224 DLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKK 283 Query: 285 ---AIRKVTWSPHHSNILMSASYDMTCRIWRDLSN 316 + WS S L S D R+W N Sbjct: 284 IVPECVSIAWSADGST-LYSGYTDNVIRVWGVSEN 317 Score = 63.0 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 29/213 (13%), Positives = 62/213 (29%), Gaps = 42/213 (19%) Query: 165 KSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLF--DIRLPSGKNQNNFLVHSGLE 222 TG + Q +P V+S S + + + S + Sbjct: 7 GQLTGHRGWVTSLACPQ-TPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEG 65 Query: 223 ALTCDFN---KYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIP 279 + + D+++R+W+++ C + Sbjct: 66 HSAFVSDVALSNNGNFAVSASWDHSLRLWNLQN-------------------GQCQYKFL 106 Query: 280 NAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFT 339 H + V +SP + I +S D R+W ++ + + Sbjct: 107 -GHTKDVLSVAFSPDNRQI-VSGGRDNALRVW-NVKGECMHTLSR--------------G 149 Query: 340 QHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H+++V +S + S WD + VW+ Sbjct: 150 AHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWD 182 >2YNP-A nrPDB Length = 604 Score = 84.2 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 38/216 (17%), Positives = 72/216 (33%), Gaps = 35/216 (16%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 + VL D T++L++ F+ HE V +N + F S D ++K Sbjct: 107 PTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVK 166 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 190 +WS + TLT VD D+ + Sbjct: 167 VWSLGQSTPNFTLTTGQERGVNYVDYYP-------------------------LPDKPYM 201 Query: 191 LSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI 250 ++ S + ++D + H + F+ P ++ +G D ++IW+ Sbjct: 202 ITASDDLTIKIWD--YQTKSCVATLEGHMSNVSFAV-FHPTLP-IIISGSEDGTLKIWN- 256 Query: 251 RMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAI 286 + + +++T+ L S CI P I Sbjct: 257 -----SSTYKVEKTLNVGLERSWCIATHPTGRKNYI 287 Score = 81.9 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 62/342 (18%), Positives = 110/342 (32%), Gaps = 88/342 (25%) Query: 41 FILEIDRSGRI--------VEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTF 92 ++L SGR+ VEV S + + +N ++V D +R+F+ Sbjct: 27 WVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNT 86 Query: 93 KEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITK 152 E + F+ H + S + LS S D ++K+W+ +L Sbjct: 87 GEK-VVDFEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNWENNWAL------------ 132 Query: 153 MVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQ 212 +++F G CV F+P D + S + ++ + G++ Sbjct: 133 -----------EQTFEGHEHFVMCV---AFNPKDPSTFASGCLDRTVKVWSL----GQST 174 Query: 213 NNFLVHSGLE--ALTCDFNKYRPY-VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQL 269 NF + +G E D+ + T D I+IWD + Sbjct: 175 PNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQ------------------ 216 Query: 270 HNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTD 329 SC+ + H + + P I++S S D T +IW + K Sbjct: 217 -TKSCVATLE-GHMSNVSFAVFHPT-LPIIISGSEDGTLKIWNSSTYKVEKTLNVG---- 269 Query: 330 ATKGSIFNFTQHSEFVFGADWS----LWGKPGYVASTAWDGN 367 W G+ Y+AS +G Sbjct: 270 ----------------LERSWCIATHPTGRKNYIASGFDNGF 295 Score = 62.2 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 91/305 (29%), Gaps = 83/305 (27%) Query: 98 AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPL 157 F V +++ L++ + G +++W+ + R +++T+ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPW-VLTTLYSGRVELWNYET-----QVEVRSIQVTETPVRA 60 Query: 158 NAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLV 217 I +K N ++ S + +F+ +G+ +F Sbjct: 61 GKFIARK-----------------------NWIIVGSDDFRIRVFN--YNTGEKVVDFEA 95 Query: 218 HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINE 277 H + + +PYV+ +G D +++W+ + + + Sbjct: 96 HPDY-IRSIAVHPTKPYVL-SGSDDLTVKLWNWEN-------------------NWALEQ 134 Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR---------------------DLSN 316 H + V ++P + S D T ++W D Sbjct: 135 TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYP 194 Query: 317 DGAKETYKTNSTD--------ATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNL 368 K T S D TK + H V A + + S + DG L Sbjct: 195 LPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHP--TLPIIISGSEDGTL 252 Query: 369 FVWNG 373 +WN Sbjct: 253 KIWNS 257 >5WLC-LO nrPDB Length = 923 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 69/444 (15%), Positives = 131/444 (29%), Gaps = 121/444 (27%) Query: 13 GVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLT-----------QD 61 V++SP D RL A F L+I ++ + + F QD Sbjct: 101 AVKFSP--DGRLFALASGRF----------LQIWKTPDVNKDRQFAPFVRHRVHAGHFQD 148 Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIA--IFKEHEREVFSCNWNLVNRQN 119 + L W++ +L D + +++ +E +A F H V ++ Sbjct: 149 -ITSLTWSQ-DSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQE-K 205 Query: 120 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQ 179 + S DG++ +W ++ S + + ++ + N+ V Sbjct: 206 IYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKC 265 Query: 180 AQFSPHDQNLVLSCSGNSYASLFDI-------RLPSGKNQNNFLVH-------------- 218 F P L+ + L+D+ +L G+N N + Sbjct: 266 VTFHP-ATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKL 324 Query: 219 -------------------SGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESA 259 + ++ V T D I++WDI Sbjct: 325 GQLLVYEWQSESYILKQQGHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDI--------- 374 Query: 260 TIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLS---- 315 + C+ H ++ V ++ ++ S+S D T R W + Sbjct: 375 ----------TSGFCLATFEE-HTSSVTAVQFAKRG-QVMFSSSLDGTVRAWDLIRYRNF 422 Query: 316 -NDGAKETYKTNSTDATK-------GSIFNF----------------TQHSEFVFGADWS 351 E + N GS+ NF + H V +S Sbjct: 423 RTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS 482 Query: 352 LWGKPGYVASTAWDGNLFVWNGLG 375 +AS +WD + +W+ G Sbjct: 483 QENS--VLASASWDKTIRIWSIFG 504 Score = 82.3 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 50/298 (16%), Positives = 109/298 (36%), Gaps = 28/298 (9%) Query: 32 FGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTT 91 FG G+L + E I++ D LA++ ++V+ A DG ++++D T Sbjct: 319 FGSSKLGQLLVYEWQSESYILKQQGHF--DSTNSLAYSP-DGSRVVTASEDGKIKVWDIT 375 Query: 92 FKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRP-LEI 150 +A F+EH V + + Q SSS DG+++ W +R ++ T T ++ Sbjct: 376 SGFC-LATFEEHTSSVTAVQF-AKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQF 433 Query: 151 TKM-VDPLNAIILKKK---------------SFTGISKNRNCVYQAQFSPHDQNLVLSCS 194 + VDP ++ +S + V FS + +++ S S Sbjct: 434 NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASAS 492 Query: 195 GNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 + ++ I G++Q + + L VA + I I++I Sbjct: 493 WDKTIRIWSI---FGRSQQVEPIEVYSDVLALSMRP-DGKEVAVSTLKGQISIFNIEDAK 548 Query: 255 KNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 312 + + ++ + N + + +S +++ + + ++ Sbjct: 549 QVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYS-FDGMAIVAGGNNNSICLYD 605 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 45/241 (18%), Positives = 93/241 (38%), Gaps = 36/241 (14%) Query: 134 PLRKQSLMTLTPRPLEITKMVDPLNAI--ILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 191 + +Q +T + ++ V ++ ++ KSFT ++R + + L++ Sbjct: 13 TVYRQGNITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQG-TLLI 71 Query: 192 SCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 251 S + A L + + + + NF + F+ + A ++IW + Sbjct: 72 SIDEDGRAILVNFKARNVLHHFNFKE----KCSAVKFSP-DGRLFALASG-RFLQIW--K 123 Query: 252 MLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 + N+ V ++H H I +TWS S +++ S D++ +IW Sbjct: 124 TPDVNKDRQFAPFVRHRVHA---------GHFQDITSLTWS-QDSRFILTTSKDLSAKIW 173 Query: 312 RDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 S D ++ + F H ++V GA +S + Y + + DG +FVW Sbjct: 174 ---SVDSEEKNLAATT----------FNGHRDYVMGAFFSHDQEKIY--TVSKDGAVFVW 218 Query: 372 N 372 Sbjct: 219 E 219 Score = 39.1 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 31/248 (12%), Positives = 70/248 (28%), Gaps = 56/248 (22%) Query: 70 ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 Q+L G+ + +FD + ++ H + + + + N +S DG Sbjct: 23 SDDGKQLLSPVGNR-VSVFDLINNKSFTFEYE-HRKNIAAIDLNK-QGTLLISIDEDGRA 79 Query: 130 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNL 189 + + K ++ + +FSP Sbjct: 80 IL----------------------------VNFKARNVLHHFNFKEKCSAVKFSPDG--R 109 Query: 190 VLSCSGNSYASLFDIRLPSGKNQ-----NNFLVHSGLEALTCDFNKYRPYVVATGGVDNA 244 + + + + ++ + Q + + + +T + T D + Sbjct: 110 LFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLS 169 Query: 245 IRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASY 304 +IW + KN +AT N H + +S H + + S Sbjct: 170 AKIWSVDSEEKNLAATTF-----------------NGHRDYVMGAFFS-HDQEKIYTVSK 211 Query: 305 DMTCRIWR 312 D +W Sbjct: 212 DGAVFVWE 219 >5CXC-A nrPDB Length = 510 Score = 83.0 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 60/316 (18%), Positives = 110/316 (34%), Gaps = 44/316 (13%) Query: 73 ENQVLVAQGDGTLRLFDTTFKEF------PIAIFKEHEREVFSCNWNLVNRQNFLSSSWD 126 +++ A D T+R++ T + P H V + + + ++ L++S D Sbjct: 203 SDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDG-HSKHILTASAD 261 Query: 127 GSIKIWSPLRKQS---LMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFS 183 G+I WS + + +L P + + ++ S + A F Sbjct: 262 GAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFD 321 Query: 184 PHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPY-VVATGGVD 242 P D+ + S S + D L +G+ + + L +L+ ++A G Sbjct: 322 PRDRTVAYSASQDHTVRTLD--LTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSA 379 Query: 243 NAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSA 302 I + D R + S R H + ++ SP + L+S Sbjct: 380 RHITMVDPRASSATTSVMTLR-----------------GHANKVVSLSPSPENEYSLVSG 422 Query: 303 SYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVAST 362 S+D TCR+W S A T + S ++ + W+ GK + Sbjct: 423 SHDGTCRVWDLRSVRPA--TKEEGSLGGVSEPVYV-------IERESWASKGKKKRPVAG 473 Query: 363 AWDG---NLFVWNGLG 375 DG VW+ LG Sbjct: 474 --DGCKVFSVVWDKLG 487 Score = 45.3 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 16/100 (16%), Positives = 37/100 (37%), Gaps = 5/100 (5%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFD--TTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 120 L L + + + + D + + + H +V S + + N + Sbjct: 360 LSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSL 419 Query: 121 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAI 160 +S S DG+ ++W +S+ T + + +P+ I Sbjct: 420 VSGSHDGTCRVWDL---RSVRPATKEEGSLGGVSEPVYVI 456 >5OPT-p nrPDB Length = 318 Score = 82.3 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 54/304 (17%), Positives = 109/304 (35%), Gaps = 67/304 (22%) Query: 70 ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 ++ + + A D +LRL++ H ++V S ++ NRQ +S D ++ Sbjct: 76 SNNGDFAVSASWDHSLRLWNLQTGVCQHKFL-GHTKDVLSVTFSPDNRQ-IVSGGRDNAL 133 Query: 130 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP-HDQN 188 ++W+ ++ + L TL G + + V +FSP + Sbjct: 134 RVWN-VKGECLHTL-------------------------GRGAHTDWVSCVRFSPSLETP 167 Query: 189 LVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 L++S ++ ++DI SG+ + H+ + + + A+ D R+W Sbjct: 168 LIVSGGWDNLVKVWDIA--SGRLLTDLKGHTNY-ITSVTVSP-DGSLCASSDKDGVARLW 223 Query: 249 DIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTC 308 D+ ++E+ A G I ++ +SP + M A+ + Sbjct: 224 DL-------------------TKGEALSEM--AAGAPINQICFSP--NRYWMCAATEKGI 260 Query: 309 RIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNL 368 RI+ + D E ++ + WS G Y S D + Sbjct: 261 RIFDLENKDVIVELAPEAQQK---------SKKTPECMSIAWSADGNTLY--SGYTDNVI 309 Query: 369 FVWN 372 VW+ Sbjct: 310 RVWS 313 Score = 66.1 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 39/257 (15%), Positives = 69/257 (26%), Gaps = 49/257 (19%) Query: 56 SFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLV 115 FL Q++ D LR+++ + H V ++ Sbjct: 104 KFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPS 163 Query: 116 NRQ-NFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNR 174 +S WD +K+W + L L IT + Sbjct: 164 LETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSP----------------- 206 Query: 175 NCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPY 234 D +L S + A L+D L G+ + + + + F+ Sbjct: 207 -----------DGSLCASSDKDGVARLWD--LTKGEALSEMAAGAPINQIC--FSP--NR 249 Query: 235 VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 + IRI+D+ + + + C + WS Sbjct: 250 YWMCAATEKGIRIFDLENKDVIVELAPEAQQKSK-KTPEC------------MSIAWSA- 295 Query: 295 HSNILMSASYDMTCRIW 311 N L S D R+W Sbjct: 296 DGNTLYSGYTDNVIRVW 312 Score = 58.0 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 26/187 (13%), Positives = 62/187 (33%), Gaps = 41/187 (21%) Query: 191 LSCSGNSYASLF--DIRLPSGKNQNNFLVHSGLEALTCDFN---KYRPYVVATGGVDNAI 245 +S S ++ + ++ S + + F + + D+++ Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSL 91 Query: 246 RIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYD 305 R+W+++ C ++ H + VT+SP + I +S D Sbjct: 92 RLWNLQ-------------------TGVCQHKFL-GHTKDVLSVTFSPDNRQI-VSGGRD 130 Query: 306 MTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWD 365 R+W ++ + + H+++V +S + + S WD Sbjct: 131 NALRVW-NVKGECLHTLGR--------------GAHTDWVSCVRFSPSLETPLIVSGGWD 175 Query: 366 GNLFVWN 372 + VW+ Sbjct: 176 NLVKVWD 182 >5FA5-B nrPDB Length = 367 Score = 81.9 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 58/313 (18%), Positives = 103/313 (32%), Gaps = 72/313 (23%) Query: 59 TQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPI---AIFKEHEREVFSCNWNLV 115 T+ + DL W +LVA G + L++ E I EH+ V + + L Sbjct: 104 TEAGVADLTWVGERG--ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSV-LS 160 Query: 116 NRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRN 175 + +S S D IK+W ++ L + ++T Sbjct: 161 SGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTC----------------------- 197 Query: 176 CVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYV 235 SPH ++ LSCS ++ L+D R P +Q G + ++ + V Sbjct: 198 ----VAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCS-APGYLPTSLAWHPQQSEV 252 Query: 236 VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 295 G + + + D + + S+ H + + +SPH Sbjct: 253 FVFGDENGTVSLVDTKSTSCVLSSA--------------------VHSQCVTGLVFSPHS 292 Query: 296 SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGK 355 L S S D + + D++ +F H +FV A WS Sbjct: 293 VPFLASLSEDCSLAV-----------------LDSSLSELFRSQAHRDFVRDATWSPLNH 335 Query: 356 PGYVASTAWDGNL 368 + + WD + Sbjct: 336 S-LLTTVGWDHQV 347 Score = 75.7 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 52/304 (17%), Positives = 96/304 (31%), Gaps = 53/304 (17%) Query: 7 QGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLT--QDCLF 64 +GF GVQ + V +G + + E+D + ++ V+ F D + Sbjct: 95 EGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLI-VSKFCKYEHDDIV 153 Query: 65 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSS 124 S Q + D ++++D ++ ++ ++ H +V + FLS S Sbjct: 154 STVSVLSSGTQAVSGSKDICIKVWDL-AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCS 212 Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 D I +W K S G S + P Sbjct: 213 EDNRILLWDTRCP-------------------------KPASQIGCSAPGYLPTSLAWHP 247 Query: 185 HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNA 244 + + N SL D + S + VHS F+ + +A+ D + Sbjct: 248 QQSEVFVFGDENGTVSLVDTK--STSCVLSSAVHSQC-VTGLVFSPHSVPFLASLSEDCS 304 Query: 245 IRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASY 304 + + D + S AH +R TWSP + ++L + + Sbjct: 305 LAVLDSSLSELFRS---------------------QAHRDFVRDATWSPLNHSLLTTVGW 343 Query: 305 DMTC 308 D Sbjct: 344 DHQV 347 >5I2T-A nrPDB Length = 742 Score = 81.5 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 66/429 (15%), Positives = 126/429 (29%), Gaps = 121/429 (28%) Query: 37 NGKLFILEIDRSGRIVEV---------NSFLT-----------QDCLFDLAWNESHENQV 76 +G+LF L SGR +++ F QD + L W++ + Sbjct: 132 DGRLFALA---SGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQD-ITSLTWSQ-DSRFI 186 Query: 77 LVAQGDGTLRLFDTTFKEFPIA--IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSP 134 L D + +++ +E +A F H V ++ + S DG++ +W Sbjct: 187 LTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQE-KIYTVSKDGAVFVWEF 245 Query: 135 LRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCS 194 ++ S + + ++ + N+ V F P L+ Sbjct: 246 TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP-ATRLLAVGF 304 Query: 195 GNSYASLFDI-------RLPSGKNQNNFLVH----------------------------- 218 + L+D+ +L G+N N + Sbjct: 305 TSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYIL 364 Query: 219 ----SGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSC 274 + ++ V T D I++WDI + C Sbjct: 365 KQQGHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDI-------------------TSGFC 404 Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLS-----NDGAKETYKTNSTD 329 + H ++ V ++ ++ S+S D T R W + E + N Sbjct: 405 LATFEE-HTSSVTAVQFAKRG-QVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLA 462 Query: 330 ATK-------GSIFNF----------------TQHSEFVFGADWSLWGKPGYVASTAWDG 366 GS+ NF + H V +S +AS +WD Sbjct: 463 VDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENS--VLASASWDK 520 Query: 367 NLFVWNGLG 375 + +W+ G Sbjct: 521 TIRIWSIFG 529 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 52/328 (15%), Positives = 116/328 (35%), Gaps = 28/328 (8%) Query: 32 FGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTT 91 FG G+L + E I++ D LA++ ++V+ A DG ++++D T Sbjct: 344 FGSSKLGQLLVYEWQSESYILKQQGHF--DSTNSLAYSP-DGSRVVTASEDGKIKVWDIT 400 Query: 92 FKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRP-LEI 150 +A F+EH V + + Q SSS DG+++ W +R ++ T T ++ Sbjct: 401 SGFC-LATFEEHTSSVTAVQF-AKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQF 458 Query: 151 TKM-VDPLNAIILKKK---------------SFTGISKNRNCVYQAQFSPHDQNLVLSCS 194 + VDP ++ +S + V FS + +++ S S Sbjct: 459 NCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASAS 517 Query: 195 GNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 + ++ I G++Q + + L VA + I I++I Sbjct: 518 WDKTIRIWSI---FGRSQQVEPIEVYSDVLALSMRP-DGKEVAVSTLKGQISIFNIEDAK 573 Query: 255 KNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDL 314 + + ++ + N + + +S +++ + + ++ Sbjct: 574 QVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYS-FDGMAIVAGGNNNSICLYDVP 632 Query: 315 SNDGAKETYKTNSTDATKGSIFNFTQHS 342 + K + + F ++ Sbjct: 633 NEVLLKRFIVSRNMALNGTLEFLNSKKM 660 Score = 51.1 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 45/241 (18%), Positives = 93/241 (38%), Gaps = 36/241 (14%) Query: 134 PLRKQSLMTLTPRPLEITKMVDPLNAI--ILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 191 + +Q +T + ++ V ++ ++ KSFT ++R + + L++ Sbjct: 38 TVYRQGNITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQG-TLLI 96 Query: 192 SCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 251 S + A L + + + + NF + F+ + A ++IW + Sbjct: 97 SIDEDGRAILVNFKARNVLHHFNFKE----KCSAVKFSP-DGRLFALASG-RFLQIW--K 148 Query: 252 MLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 + N+ V ++H H I +TWS S +++ S D++ +IW Sbjct: 149 TPDVNKDRQFAPFVRHRVHA---------GHFQDITSLTWS-QDSRFILTTSKDLSAKIW 198 Query: 312 RDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 S D ++ + F H ++V GA +S + Y + + DG +FVW Sbjct: 199 ---SVDSEEKNLAATT----------FNGHRDYVMGAFFSHDQEKIY--TVSKDGAVFVW 243 Query: 372 N 372 Sbjct: 244 E 244 Score = 38.4 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 31/248 (12%), Positives = 70/248 (28%), Gaps = 56/248 (22%) Query: 70 ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 Q+L G+ + +FD + ++ H + + + + N +S DG Sbjct: 48 SDDGKQLLSPVGNR-VSVFDLINNKSFTFEYE-HRKNIAAIDLNK-QGTLLISIDEDGRA 104 Query: 130 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNL 189 + + K ++ + +FSP Sbjct: 105 IL----------------------------VNFKARNVLHHFNFKEKCSAVKFSPDG--R 134 Query: 190 VLSCSGNSYASLFDIRLPSGKNQ-----NNFLVHSGLEALTCDFNKYRPYVVATGGVDNA 244 + + + + ++ + Q + + + +T + T D + Sbjct: 135 LFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLS 194 Query: 245 IRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASY 304 +IW + KN +AT N H + +S H + + S Sbjct: 195 AKIWSVDSEEKNLAATTF-----------------NGHRDYVMGAFFS-HDQEKIYTVSK 236 Query: 305 DMTCRIWR 312 D +W Sbjct: 237 DGAVFVWE 244 >5YZG-W nrPDB Length = 579 Score = 80.7 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 49/327 (14%), Positives = 101/327 (30%), Gaps = 53/327 (16%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL 121 + + + +L D ++L++ + + F H + V +N FL Sbjct: 290 GVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFN-TAGTQFL 348 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDP--------LNAIILKKKSFTGISKN 173 S+++D +K+W Q + T R + +P + + KK I Sbjct: 349 SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSG 408 Query: 174 RNCVYQAQFSP--------HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALT 225 + + +S S + +++ +P + A+T Sbjct: 409 EIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVT 468 Query: 226 CDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLA 285 N +A +DN I I+ + + K + +C Sbjct: 469 LSPN---GKWLACQSMDNQILIFGAQN--RFRLNKKKIFKGHMVAGYAC----------- 512 Query: 286 IRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFV 345 +V +SP + ++S + IW + F H + Sbjct: 513 --QVDFSP-DMSYVISGDGNGKLNIWDWKTTK----------------LYSRFKAHDKVC 553 Query: 346 FGADWSLWGKPGYVASTAWDGNLFVWN 372 GA W + V + WDG + +W+ Sbjct: 554 IGAVWHP-HETSKVITCGWDGLIKLWD 579 Score = 64.5 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 41/240 (17%), Positives = 75/240 (31%), Gaps = 44/240 (18%) Query: 135 LRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCS 194 + +S + + + P L KK S + V + P +L+LSCS Sbjct: 249 YQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCS 308 Query: 195 GNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 + L+++ + F+ HS C FN + + D +++WD Sbjct: 309 MDCKIKLWEV-YGERRCLRTFIGHSKAVRDIC-FNTAGTQFL-SAAYDRYLKLWDTE--- 362 Query: 255 KNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH--SNILMSASYDMTCRIWR 312 CI+ N V ++P N+ ++ D W Sbjct: 363 ----------------TGQCISRFTN--RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 404 Query: 313 DLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 S + +E + +H V + + ST+ D +L VW Sbjct: 405 IRSGEIVQE----------------YDRHLGAVNTIVFVDENRRFV--STSDDKSLRVWE 446 >4L9O-A nrPDB Length = 349 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 52/322 (16%), Positives = 91/322 (28%), Gaps = 64/322 (19%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTT-FKEFPIAIFKEHEREVFSCNW-NLVNR 117 D L A + + ++ D T+++F+ + + HE V+ W + Sbjct: 68 HDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFG 127 Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 177 S S+DG + IW S ++ V Sbjct: 128 VILASCSYDGKVLIWKEDNGVWNKVAE-------------------------HSVHQASV 162 Query: 178 YQAQFSPHD-QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYR---- 232 ++PH+ ++L S + S+ + + H + + Sbjct: 163 NSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGH-AIGVNAASWAPISLPDN 221 Query: 233 PYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWS 292 +GG DN ++IW K E H +R V WS Sbjct: 222 TRRFVSGGCDNLVKIWRYDDAAKTFIE----------------EEAFQGHSDWVRDVAWS 265 Query: 293 PH--HSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADW 350 P + + +AS D T IW E + A W Sbjct: 266 PSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDV-----------CWRASW 314 Query: 351 SLWGKPGYVASTAWDGNLFVWN 372 SL G ++ D + +W Sbjct: 315 SLSGNVLAISGG--DNKVTLWK 334 Score = 71.1 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 40/268 (14%), Positives = 81/268 (30%), Gaps = 65/268 (24%) Query: 116 NRQNFLSSSWDGSIKIW--SPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 173 + + S D +IKI+ ++ + TL + ++ Sbjct: 80 YGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQV-------------------- 119 Query: 174 RNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYR- 232 A P ++ SCS + ++ VH + + + Sbjct: 120 ------AWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQ-ASVNSVSWAPHEY 172 Query: 233 PYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWS 292 V+ D I I + + + + H + + +W+ Sbjct: 173 GPVLLCASSDGKISIVEFK------------------DGGALEPIVIQGHAIGVNAASWA 214 Query: 293 P----HHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGA 348 P ++ +S D +IWR +D AK + + F HS++V Sbjct: 215 PISLPDNTRRFVSGGCDNLVKIWR--YDDAAKTFIEEEA----------FQGHSDWVRDV 262 Query: 349 DWSLWG-KPGYVASTAWDGNLFVWNGLG 375 WS Y+A+ + D + +W G Sbjct: 263 AWSPSRLSKSYIATASQDRTVLIWTKDG 290 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 75/222 (33%), Gaps = 32/222 (14%) Query: 37 NGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESH-ENQVLVAQGDGTLRLFDTTFKEF 95 +GK+ I + D + Q + ++W +L A DG + + + Sbjct: 136 DGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGA 195 Query: 96 -PIAIFKEHEREVFSCNWNL----VNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEI 150 + + H V + +W N + F+S D +KIW Sbjct: 196 LEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIW------------------ 237 Query: 151 TKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHD--QNLVLSCSGNSYASLFDIRLPS 208 D +++++F G S + V +SP ++ + + S + ++ S Sbjct: 238 --RYDDAAKTFIEEEAFQGHS---DWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKS 292 Query: 209 GKNQNNFLVHSGLEALTCDFN-KYRPYVVATGGVDNAIRIWD 249 K + L + + V+A G DN + +W Sbjct: 293 NKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWK 334 >6QDV-o nrPDB Length = 513 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 49/327 (14%), Positives = 101/327 (30%), Gaps = 53/327 (16%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL 121 + + + +L D ++L++ + + F H + V +N FL Sbjct: 224 GVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFN-TAGTQFL 282 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDP--------LNAIILKKKSFTGISKN 173 S+++D +K+W Q + T R + +P + + KK I Sbjct: 283 SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSG 342 Query: 174 RNCVYQAQFSP--------HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALT 225 + + +S S + +++ +P + A+T Sbjct: 343 EIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVT 402 Query: 226 CDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLA 285 N +A +DN I I+ + + K + +C Sbjct: 403 LSPN---GKWLACQSMDNQILIFGAQN--RFRLNKKKIFKGHMVAGYAC----------- 446 Query: 286 IRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFV 345 +V +SP + ++S + IW + F H + Sbjct: 447 --QVDFSP-DMSYVISGDGNGKLNIWDWKTTK----------------LYSRFKAHDKVC 487 Query: 346 FGADWSLWGKPGYVASTAWDGNLFVWN 372 GA W + V + WDG + +W+ Sbjct: 488 IGAVWHP-HETSKVITCGWDGLIKLWD 513 Score = 64.2 bits (154), Expect = 8e-11, Method: Composition-based stats. Identities = 39/240 (16%), Positives = 74/240 (30%), Gaps = 44/240 (18%) Query: 135 LRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCS 194 + +S + + + P L KK S + V + P +L+LSCS Sbjct: 183 YQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCS 242 Query: 195 GNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 + L+++ + F+ HS +A+ + D +++WD Sbjct: 243 MDCKIKLWEV-YGERRCLRTFIGHS--KAVRDICFNTAGTQFLSAAYDRYLKLWDTE--- 296 Query: 255 KNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH--SNILMSASYDMTCRIWR 312 CI+ N V ++P N+ ++ D W Sbjct: 297 ----------------TGQCISRFTN--RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWD 338 Query: 313 DLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 S + +E + +H V + + ST+ D +L VW Sbjct: 339 IRSGEIVQE----------------YDRHLGAVNTIVFVDENRRFV--STSDDKSLRVWE 380 >2AQ5-A nrPDB Length = 402 Score = 79.6 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 87/248 (35%), Gaps = 45/248 (18%) Query: 36 GNGKLFILEIDRSGRIVEVNSFLTQDC-----LFDLAWNESHENQVLVAQGDGTLRLFDT 90 G G +L + ++GR V+ + C + D+AW ++N + D T+ +++ Sbjct: 55 GGGAFLVLPLGKTGR---VDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEI 111 Query: 91 TFKE------FPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT 144 P+ + H + V W+ + LS+ D I +W +++TL Sbjct: 112 PDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLG 171 Query: 145 PRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI 204 P + + +Y +S D L+ + + + + Sbjct: 172 P-------------------------DVHPDTIYSVDWS-RDGALICTSCRDKRVRVIEP 205 Query: 205 RLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATG---GVDNAIRIWDIRMLNKNESATI 261 R + + + H G + F ++ TG + + +WD + L + S Sbjct: 206 RKGTVVAEKDRP-HEGTRPVHAVFVS-EGKILTTGFSRMSERQVALWDTKHLEEPLSLQE 263 Query: 262 KRTVPGQL 269 T G L Sbjct: 264 LDTSSGVL 271 Score = 56.8 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 30/189 (15%), Positives = 57/189 (30%), Gaps = 30/189 (15%) Query: 183 SPHDQNLVLSCSGNSYASLFDIRLPSGKNQNN-FLVHSGLEALTCDFNKYRPYVVATGGV 241 +P L+ SG + + ++N + L + + V+A+G Sbjct: 43 NPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSE 102 Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMS 301 D + +W+I G + H + V W P N+L+S Sbjct: 103 DCTVMVWEI-------------PDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLS 149 Query: 302 ASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVAS 361 A D +W + H + ++ DWS G + + Sbjct: 150 AGCDNVILVWDVGTGAAVLTLGPDV--------------HPDTIYSVDWSRDG--ALICT 193 Query: 362 TAWDGNLFV 370 + D + V Sbjct: 194 SCRDKRVRV 202 Score = 52.2 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 33/95 (34%), Gaps = 10/95 (10%) Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFN 337 + H + + W PH+ N++ S S D T +W E + + Sbjct: 76 LVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVW---------EIPDGGLVLPLREPVIT 126 Query: 338 FTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H++ V W + + S D + VW+ Sbjct: 127 LEGHTKRVGIVAWHPTAQN-VLLSAGCDNVILVWD 160 >5OQL-J nrPDB Length = 912 Score = 79.2 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 54/359 (15%), Positives = 104/359 (28%), Gaps = 94/359 (26%) Query: 59 TQDCLFDLAWNESHENQVLVAQGDGTLRLFDT----------------TFKEFPIAIFKE 102 T D + DL + ++ + +A +R+ ++ +A+ K Sbjct: 372 THDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKG 431 Query: 103 HEREVFSCNWNLVNRQNFLSSSWDGSIKIW--SPLRKQ--SLMTLTPRPLEITKMVDPLN 158 HE V S + + S S D + ++W P T + + P Sbjct: 432 HEDIVMSLDVDWSGHW-IASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKV 490 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI--RLPSGKNQNNFL 216 ++F H ++S S + + DI +L G + L Sbjct: 491 VPPANSEAFKNPLD------------HPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSL 538 Query: 217 --VHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSC 274 + + D + + A+ D ++IWD+ L Sbjct: 539 RRLAHDKDINALDISP-NGKLFASASQDKTVKIWDVEKLEVQG----------------- 580 Query: 275 INEIPNAHGLAIRKVTWSPHHSNIL-------------MSASYDMTCRIWRDLSNDGAKE 321 I H + V ++P ++ ++ ++ S D T ++W + Sbjct: 581 ---ILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRT 637 Query: 322 TYKTNSTDATKGSIFNFTQHSEFVFGADW-------SLWGKPGYVASTAWDGNLFVWNG 373 F HS V W S+ AS D + VW+ Sbjct: 638 ----------------FEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDA 680 Score = 71.9 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 75/219 (34%), Gaps = 39/219 (17%) Query: 44 EIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEH 103 ++ + G++ L D + + A D T++++D K I + H Sbjct: 527 QLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVE-KLEVQGILRGH 585 Query: 104 EREVFSCNWNLVN-------------RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEI 150 +R V++ + +N R L+ S D +IK+W+ + T + Sbjct: 586 KRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNV 645 Query: 151 TKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK 210 K + L I+K + QF+ S ++ ++D + Sbjct: 646 LK------VVWLHISRDDSITKTK-----VQFA--------SAGADTLVKVWDANTGETE 686 Query: 211 N-QNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 +N A+ N ++A+ G D+ + W Sbjct: 687 CTLDNHEDRLWTLAVHSKTN-----ILASAGSDSKVTFW 720 Score = 65.3 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 60/366 (16%), Positives = 114/366 (31%), Gaps = 77/366 (21%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLF---DTTFKEFPIAIFKEHEREVFSCNWNLVN 116 + ++ +L D T+ L+ D ++ P+ + E F L Sbjct: 231 HESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGF-----LNE 285 Query: 117 RQNFLSSSWDGSIKIWSPLRKQ----------------SLMTLTPRPLEITKMVD----- 155 + S+ G ++IW S ++L R L + D Sbjct: 286 GKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVL 345 Query: 156 ---PLNAIILKKKS------FTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRL 206 P A ++ F IS + + + DQ+++ + + + ++ Sbjct: 346 YRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKD 405 Query: 207 PSGKNQNN--------------FLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRM 252 +++N L ++ D + + +A+G DN R+W R+ Sbjct: 406 AQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDV-DWSGHWIASGSKDNTARLW--RV 462 Query: 253 LNKNESATIKRTVPGQLHNSSCI---NEIPNAHGLAIRKVTWSPHHSN--ILMSASYDMT 307 N S T G L + + +P A+ A + +P L+S S D Sbjct: 463 DPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFK----NPLDHPPAFLISGSQDR- 517 Query: 308 CRIWRDLSNDGAKETYKTNSTDATK-GSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDG 366 K K S H + + D S GK AS + D Sbjct: 518 ---------FVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGK--LFASASQDK 566 Query: 367 NLFVWN 372 + +W+ Sbjct: 567 TVKIWD 572 Score = 51.8 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 32/273 (11%), Positives = 78/273 (28%), Gaps = 38/273 (13%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKE-----FPIA--IFKEHEREVFSCNWNLVNRQNFLSS 123 + ++V T+R++ P K H V + + Sbjct: 71 PSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRT-STLLATG 129 Query: 124 SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSF--TGISKNRNCVYQAQ 181 + DG+IKIW + T++ + ++ + A+ + +S +R Sbjct: 130 AADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDA 189 Query: 182 FSPHDQNLVLSCSGNSYASLFDIRLPSGK----NQNNFLVHSGLEALTCDFNKYRPYVVA 237 + + + + +FD+ + + ++ + + Sbjct: 190 DEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP-EQHALL 248 Query: 238 TGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSN 297 +G D + +W L ++ + +L + V + Sbjct: 249 SGSRDKTMTLW----LWRDGIWQGTPMLRHEL----------------LESVGFLNEGK- 287 Query: 298 ILMSASYDMTCRIWRDLS--NDGAKETYKTNST 328 + SA RIW + K+ K+ Sbjct: 288 WMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGE 320 Score = 39.1 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 35/254 (13%), Positives = 68/254 (26%), Gaps = 32/254 (12%) Query: 135 LRKQSLMTLTPRPLEITKMVDPLNAIILKK-KSFTGISKNRNCVYQAQFSPHDQNLVLSC 193 S+ + + + + L K I + + +P +L++ C Sbjct: 21 YTGGSVALENGARILASTLGENAILTELNTGKRLAEIQGDGEPISTLTITPSGSHLIV-C 79 Query: 194 SGNSYASLFDIRLPS-------GKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIR 246 S + ++ + + + + + L D ++ATG D AI+ Sbjct: 80 SRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVD---RTSTLLATGAADGAIK 136 Query: 247 IWDIRMLNKNESATIKRTVPGQLHNSSCINEIP---------NAHGLAIRKVTWSPHHSN 297 IWDI + + + LH Sbjct: 137 IWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRF 196 Query: 298 ILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPG 357 L + D RI+ YK +T H V +S Sbjct: 197 RLAWGTQDGRIRIFD---------LYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHA- 246 Query: 358 YVASTAWDGNLFVW 371 + S + D + +W Sbjct: 247 -LLSGSRDKTMTLW 259 Score = 30.6 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 20/118 (16%), Positives = 44/118 (37%), Gaps = 12/118 (10%) Query: 258 SATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND 317 S + + +L+ + EI G I +T +P S++++ + +T RI+ Sbjct: 37 STLGENAILTELNTGKRLAEIQ-GDGEPISTLTITPSGSHLIVCSRS-LTMRIYSLA--- 91 Query: 318 GAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG 375 + + H+ V + +A+ A DG + +W+ +G Sbjct: 92 -----ISPDYDSVEPTLVRTTKPHATPVVVLA--VDRTSTLLATGAADGAIKIWDIIG 142 >6HHQ-h nrPDB Length = 319 Score = 78.8 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 47/279 (16%), Positives = 87/279 (31%), Gaps = 71/279 (25%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 + H V S + LS+S D ++ W K+ Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISW-------------------KLTGDDQ 52 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH 218 + +SF G S + V + + S S + L+D+ +G+ F+ H Sbjct: 53 KFGVPVRSFKGHS---HIVQDCTLTADGAYAL-SASWDKTLRLWDVA--TGETYQRFVGH 106 Query: 219 SGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 + ++ D +K ++ +G D I++W I+ C+ + Sbjct: 107 KS-DVMSVDIDKKASMII-SGSRDKTIKVWTIK--------------------GQCLATL 144 Query: 279 PNAHGLAIRKVTWSP-----HHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKG 333 H + +V P S ++SA D + W + Sbjct: 145 L-GHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEAD------------ 191 Query: 334 SIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 F H+ + S G +AS DG + +WN Sbjct: 192 ----FIGHNSNINTLTASPDGT--LIASAGKDGEIMLWN 224 Score = 74.9 bits (182), Expect = 6e-14, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 83/272 (30%), Gaps = 61/272 (22%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEF----PIAIFKEHEREVFSCNWNLVNRQ 118 + LA + N +L A D TL + T + P+ FK H V C Sbjct: 20 VTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTAD-GA 78 Query: 119 NFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVY 178 LS+SWD ++++W ++ D ++ I KK Sbjct: 79 YALSASWDKTLRLWDVATGETYQRFVGHK------SDVMSVDIDKK-------------- 118 Query: 179 QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH----SGLEALTCDFNKYRPY 234 ++++S S + ++ I G+ L H S + + + Sbjct: 119 --------ASMIISGSRDKTIKVWTI---KGQCLATLLGHNDWVSQVRVVPNEKADDDSV 167 Query: 235 VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 + + G D ++ W++ H I +T SP Sbjct: 168 TIISAGNDKMVKAWNLNQFQIEADFI--------------------GHNSNINTLTASPD 207 Query: 295 HSNILMSASYDMTCRIWRDLSNDGAKETYKTN 326 + ++ SA D +W + + Sbjct: 208 GT-LIASAGKDGEIMLWNLAAKKAMYTLSAQD 238 Score = 68.4 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 49/323 (15%), Positives = 100/323 (30%), Gaps = 62/323 (19%) Query: 52 VEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCN 111 V V SF + + L A D TLRL+D E F H+ +V S + Sbjct: 56 VPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQ-RFVGHKSDVMSVD 114 Query: 112 WNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGIS 171 + +S S D +IK+W ++ Q L TL ++++ N Sbjct: 115 IDK-KASMIISGSRDKTIKVW-TIKGQCLATLLGHNDWVSQVRVVPNEK----------- 161 Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKY 231 + D ++S + ++ L + + +F+ H T + Sbjct: 162 -----------ADDDSVTIISAGNDKMVKAWN--LNQFQIEADFIGH-NSNINTLTASP- 206 Query: 232 RPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTW 291 ++A+ G D I +W++ + + + + + Sbjct: 207 DGTLIASAGKDGEIMLWNLAAKKAMYTLSA---------------------QDEVFSLAF 245 Query: 292 SPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 351 SP + ++A+ +++ + D WS Sbjct: 246 SP--NRYWLAAATATGIKVFSL--------DPQYLVDDLRPEFAGYSKAAEPHAVSLAWS 295 Query: 352 LWGKPGYVASTAWDGNLFVWNGL 374 G+ + + D + VW + Sbjct: 296 ADGQTLF--AGYTDNVIRVWQVM 316 Score = 48.0 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 25/98 (25%), Positives = 36/98 (36%), Gaps = 13/98 (13%) Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 334 + H + + S N+L+SAS D T W+ L+ D K S Sbjct: 9 LRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWK-LTGDDQKFGVPVRS------- 60 Query: 335 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 F HS V + G Y S +WD L +W+ Sbjct: 61 ---FKGHSHIVQDCTLTADG--AYALSASWDKTLRLWD 93 >5WBU-D nrPDB Length = 328 Score = 76.9 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 44/298 (14%), Positives = 97/298 (32%), Gaps = 61/298 (20%) Query: 120 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM-VDPLNAIILK--------------- 163 ++ +D +++ W T+ + ++ + V P ++I Sbjct: 17 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNN 76 Query: 164 KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA 223 + F D + + + A ++D+R + + Q F V++ + Sbjct: 77 PNPIISYDGVNKNIASVGFH-EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 135 Query: 224 LTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLH------------- 270 + N+ + G AI IWD++ + + H Sbjct: 136 VCLHPNQAE---LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 192 Query: 271 NSSC-INEIPNAHGLAIRKV----------------TWSPHHSNILMSASYDMTCRIWRD 313 +C + + G + ++ +SP S +L + S D TC+IWR Sbjct: 193 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRT 251 Query: 314 LSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 SN S + + S +++G +S + Y+ + + D +W Sbjct: 252 -SNFSLMTELSIKSGNPGESS-------RGWMWGCAFSGDSQ--YIVTASSDNLARLW 299 Score = 58.4 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 36/243 (14%), Positives = 70/243 (28%), Gaps = 51/243 (20%) Query: 78 VAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRK 137 D T R++D + + + + + + G+I IW Sbjct: 104 TGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTD 162 Query: 138 QSLMTLTPRPLEIT-KMVDPLNAIILKKKSF----------------------TGISKNR 174 + + + IT +DP + + S T I + Sbjct: 163 HNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHT 222 Query: 175 NCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEAL-----TCDFN 229 Q +FSP D L+ +CS + ++ S + + + E+ C F+ Sbjct: 223 RYALQCRFSP-DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFS 281 Query: 230 KYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKV 289 Y+V T DN R+W + H A+ + Sbjct: 282 GDSQYIV-TASSDNLARLWCVETGEIKREY--------------------GGHQKAVVCL 320 Query: 290 TWS 292 ++ Sbjct: 321 AFN 323 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 25/167 (14%), Positives = 52/167 (31%), Gaps = 31/167 (18%) Query: 71 SHENQVLVAQGDGTLRLFDTT-------FKEFPIAIFKEHEREVFSCNWNLVNRQNFLSS 123 + + G +++ T + P H R C ++ + Sbjct: 182 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD-STLLATC 240 Query: 124 SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFS 183 S D + KIW + L+ KS +R ++ FS Sbjct: 241 SADQTCKIWRTSNFSLMTELS-------------------IKSGNPGESSRGWMWGCAFS 281 Query: 184 PHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNK 230 Q +++ S ++ A L+ + +G+ + + H + FN Sbjct: 282 GDSQY-IVTASSDNLARLWCVE--TGEIKREYGGHQKA-VVCLAFND 324 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 11/114 (9%), Positives = 36/114 (31%), Gaps = 9/114 (7%) Query: 56 SFLTQDCLFDL-AWNESHENQVLVAQGDGTLRLFDTT--FKEFPIAIFKEHERE-----V 107 + + + L + D T +++ T+ ++I + E + Sbjct: 216 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 275 Query: 108 FSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAII 161 + C ++ Q +++S D ++W + + + + + Sbjct: 276 WGCAFSGD-SQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG 328 Score = 33.3 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 22/142 (15%), Positives = 49/142 (34%), Gaps = 40/142 (28%) Query: 232 RPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLA-IRKVT 290 P ++AT G D+ +R W Q H+ C + H + + + Sbjct: 13 DPVILATAGYDHTVRFW-------------------QAHSGICTRTVQ--HQDSQVNALE 51 Query: 291 WSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADW 350 +P +++ +A Y R++ SN+ I ++ ++ + + Sbjct: 52 VTP-DRSMIAAAGY-QHIRMYDLNSNN--------------PNPIISYDGVNKNIASVGF 95 Query: 351 SLWGKPGYVASTAWDGNLFVWN 372 G+ Y + D +W+ Sbjct: 96 HEDGRWMY--TGGEDCTARIWD 115 >3I2N-A nrPDB Length = 357 Score = 76.5 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 44/307 (14%), Positives = 102/307 (33%), Gaps = 45/307 (14%) Query: 72 HENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQN-----FLSSSWD 126 + + G L +++ E P+ K H+ + + + ++ S D Sbjct: 79 QQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRD 138 Query: 127 GSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHD 186 G++K+W P +K DP+ + + + ++ + Sbjct: 139 GTVKVWDPRQKD----------------DPVANM--EPVQGENKRDCWTVAFGNAYN-QE 179 Query: 187 QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIR 246 + +V + N LFD+R + + + N +G+ +L D + ++ Sbjct: 180 ERVVCAGYDNGDIKLFDLRNMALRWETNIK--NGVCSLEFDRKDISMNKLVATSLEGKFH 237 Query: 247 IWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDM 306 ++D+R + + AH + +V P + + ++A Sbjct: 238 VFDMRTQHPTKGFASVS---------------EKAHKSTVWQVRHLPQNRELFLTAGGAG 282 Query: 307 TCRIWRDLSNDGAKETYKTNSTDATKGS---IFNFTQHSEFVFGADWSLWGKPGYVASTA 363 +W+ + GS + N T ++ + DWS + V S + Sbjct: 283 GLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCS-S 341 Query: 364 WDGNLFV 370 +D + V Sbjct: 342 FDQTVRV 348 Score = 34.9 bits (78), Expect = 0.067, Method: Composition-based stats. Identities = 20/204 (9%), Positives = 55/204 (26%), Gaps = 26/204 (12%) Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGN---SYASLFDIRLPSGKNQNNFLVHSGLEALTCDF 228 V+ ++ P V + L++I+ K ++ T Sbjct: 16 GFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGA 75 Query: 229 NKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRK 288 + +ATG + IW++ + + I Sbjct: 76 TSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEG------- 128 Query: 289 VTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGA 348 + +++ S D T ++W D + + + + Sbjct: 129 -------APEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGEN---------KRDCWTVAF 172 Query: 349 DWSLWGKPGYVASTAWDGNLFVWN 372 + + V + +G++ +++ Sbjct: 173 GNAYNQEERVVCAGYDNGDIKLFD 196 >3JB9-g nrPDB Length = 558 Score = 76.5 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 36/296 (12%), Positives = 90/296 (30%), Gaps = 50/296 (16%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL 121 + L + + +L D +++++ + F+ H R + +++ ++FL Sbjct: 268 GISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQD-GRSFL 326 Query: 122 SSSWDGSIKIWSPLRKQSLMTL--------------TPRPLEITKMVDPLNAIIL---KK 164 S+S+D +IK+W + L +P E + Sbjct: 327 STSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSP 386 Query: 165 KSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEAL 224 + + F + ++ S +S ++ P + + + Sbjct: 387 DIVQAYDHHLGGINSITF-LENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMPRV 445 Query: 225 TCDFNKYRPYVVATGGVDNAIRIWDI-------------------RMLNKNESATIKRTV 265 N +A +DN I ++ L S + Sbjct: 446 ALRPNGKS---IACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVF 502 Query: 266 PGQLHNSSC--------INEIPNAHGLAIRKVTWSPHHSNILMSAS-YDMTCRIWR 312 G ++C + AH ++ + + P ++ + ++S D + + W Sbjct: 503 SGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 71.5 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 49/293 (16%), Positives = 93/293 (31%), Gaps = 72/293 (24%) Query: 81 GDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSL 140 G+ T + + I +K H + + + ++ LS S D IKIW +SL Sbjct: 248 GEQTCYI-----PKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSL 302 Query: 141 MTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYAS 200 + ++F G ++ + FS ++ LS S + Sbjct: 303 L-----------------------RTFQGHARP---IRDLSFSQDGRS-FLSTSFDKTIK 335 Query: 201 LFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESAT 260 L+D L GK N F + + +P G D I +DIR + ++ Sbjct: 336 LWDTEL--GKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQAY- 392 Query: 261 IKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAK 320 + H I +T+ + ++ S D + R W + K Sbjct: 393 -------------------DHHLGGINSITFL-ENGKRFVTTSDDSSMRFWEYGTPVPIK 432 Query: 321 ETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 + ++ GK +A + D ++V++ Sbjct: 433 FVADIAMHSMPRVAL---------------RPNGKS--IACQSLDNCIYVYSA 468 >5A9Q-7 nrPDB Length = 360 Score = 76.1 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 54/328 (16%), Positives = 114/328 (34%), Gaps = 46/328 (14%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKE--FPIAIFKEHEREVFSCNW-NLVN 116 +D + D++++ H ++ D +++++D + A +K H V+ W + Sbjct: 12 KDLIHDVSFDF-HGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 117 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNC 176 Q S S+D + +W + +S L + T + +R Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQS---------------HWVKRTTLVDSRTS 115 Query: 177 VYQAQFSPHDQNL-VLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPY- 234 V +F+P L + +CS + +++ +Q + H L+C + P Sbjct: 116 VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQ-HEISCKLSCSCISWNPSS 174 Query: 235 ------VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRK 288 ++A G D + N A ++ + E + Sbjct: 175 SRAHSPMIAVGSDD----------SSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHD 224 Query: 289 VTWSPHHSN---ILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFV 345 + ++P+ IL A+ D+ L + T T + F H+ V Sbjct: 225 IAFAPNLGRSFHILAIATKDVRI---FTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQV 281 Query: 346 FGADWSLWGKPGYVASTAWDGNLFVWNG 373 + W++ G +AS+ DG + +W Sbjct: 282 WRVSWNITGT--VLASSGDDGCVRLWKA 307 >2PM9-A nrPDB Length = 416 Score = 75.7 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 54/316 (17%), Positives = 102/316 (32%), Gaps = 65/316 (20%) Query: 65 DLAWNESHENQVLVAQ-GDGTLRLFDTTFKEFPI---AIFKEHEREVFSCNWNLVNRQNF 120 DL W SH N+++ +G+L L+ T I A F H V + +N Sbjct: 72 DLDW--SHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVL 129 Query: 121 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA 180 S +G I IW + P N L + + V Sbjct: 130 ASGGNNGEIFIWDMNK---------------CTESPSNYTPLTPGQS---MSSVDEVISL 171 Query: 181 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG---LEALTCDFNKYRPYVVA 237 ++ ++ S +++AS++D++ ++ + + +++ VA Sbjct: 172 AWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVA 231 Query: 238 TGGV---DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 T D +I IWD+R N + + H I + W Sbjct: 232 TATGSDNDPSILIWDLRNANTP------------------LQTLNQGHQKGILSLDWCHQ 273 Query: 295 HSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG 354 ++L+S+ D T +W S + + F + F ++ Sbjct: 274 DEHLLLSSGRDNTVLLWNPESAEQLSQ----------------FPARGNWCFKTKFAPEA 317 Query: 355 KPGYVASTAWDGNLFV 370 P A ++D + V Sbjct: 318 -PDLFACASFDNKIEV 332 Score = 58.4 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 51/286 (17%), Positives = 97/286 (33%), Gaps = 50/286 (17%) Query: 1 MLRYHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGR-------IVE 53 M R+ S V+++ DN LA +G N NG++FI ++++ + Sbjct: 106 MARFSNHSSSVKTVKFNAKQDNVLA--SGGN-----NGEIFIWDMNKCTESPSNYTPLTP 158 Query: 54 VNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIF-----KEHEREVF 108 S + D + LAWN+S + A ++D K+ I + ++++ Sbjct: 159 GQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLS 218 Query: 109 SCNWNLVNRQNFLSSS---WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKK 165 W+ N +++ D SI IW + PL Sbjct: 219 VVEWHPKNSTRVATATGSDNDPSILIWD----------------LRNANTPLQ------- 255 Query: 166 SFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALT 225 T ++ + + D++L+LS ++ L++ P Q + G Sbjct: 256 --TLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWN---PESAEQLSQFPARGNWCFK 310 Query: 226 CDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHN 271 F P + A DN I + ++ L T + Sbjct: 311 TKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETETKQQESET 356 >6J6H-n nrPDB Length = 455 Score = 75.3 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 54/312 (17%), Positives = 92/312 (29%), Gaps = 63/312 (20%) Query: 61 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 120 + L + + +L D T++++D + F+ H + + + + Q+F Sbjct: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC-QSF 221 Query: 121 LSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA 180 LSSS+D S+KIW + L P N Sbjct: 222 LSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN---------------------- 259 Query: 181 QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG 240 PH+ + NS +D R+ + H L + + Sbjct: 260 ---PHE---FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSS 312 Query: 241 VDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM 300 D +RIW+ + IK+ H+ +N P N Sbjct: 313 EDKTVRIWE-----NQINVPIKQISDTAQHSMPFLNVHP---------------SQNYFC 352 Query: 301 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA 360 + S D + K YK + F HS +G + G Y+ Sbjct: 353 AQSMDNRI------YSFSLKPKYKRHPKK-------IFKGHSSAGYGISLAFSGDGRYIC 399 Query: 361 STAWDGNLFVWN 372 S LF W+ Sbjct: 400 SGDSKSRLFTWD 411 >5K1B-B nrPDB Length = 677 Score = 75.3 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 45/252 (17%), Positives = 81/252 (32%), Gaps = 65/252 (25%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFP--IAIFKEH----EREVFSCNWNLVNRQNFLSSS 124 N++ A D +R++ + IA + H V C N + +S+S Sbjct: 40 PALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCC-----NGKTLISAS 94 Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 D ++K+W+ + + TL D + A+ K Sbjct: 95 SDTTVKVWNAHKGFCMSTLRTHK-------DYVKALAYAK-------------------- 127 Query: 185 HDQNLVLSCSGNSYASLFDIR-LPSGKNQNNFLVHSGLEALTCDFNKYR----PYVVATG 239 D+ LV S + L+D+ L + NN + S L ++ +G Sbjct: 128 -DKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSG 186 Query: 240 GVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNIL 299 + +R+WD R K H ++ + + + L Sbjct: 187 STEKVLRVWDPRTCAKLMK--------------------LKGHTDNVKALLLNRDGTQCL 226 Query: 300 MSASYDMTCRIW 311 S S D T R+W Sbjct: 227 -SGSSDGTIRLW 237 Score = 64.5 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 38/255 (14%), Positives = 81/255 (31%), Gaps = 59/255 (23%) Query: 118 QNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCV 177 ++ D I+IWS + + DP A + + + V Sbjct: 43 NRLFTAGRDSIIRIWSVNQHKQ---------------DPYIASMEH---------HTDWV 78 Query: 178 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 237 + + L+ S S ++ +++ G + H + +VA Sbjct: 79 NDIVLCCNGKTLI-SASSDTTVKVWNA--HKGFCMSTLRTHKDY--VKALAYAKDKELVA 133 Query: 238 TGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSN 297 + G+D I +WD+ L ++ T + + +I + + + Sbjct: 134 SAGLDRQIFLWDVNTLTALTASNNTVTTSS-----------LSGNKDSIYSLAMNQLGT- 181 Query: 298 ILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPG 357 I++S S + R+W AK + H++ V + G Sbjct: 182 IIVSGSTEKVLRVWD--PRTCAK--------------LMKLKGHTDNVKALLLNRDGTQ- 224 Query: 358 YVASTAWDGNLFVWN 372 S + DG + +W+ Sbjct: 225 -CLSGSSDGTIRLWS 238 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 40/94 (42%), Gaps = 3/94 (3%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQN 119 +D ++ LA N+ ++ + LR++D + K H V + N Sbjct: 168 KDSIYSLAMNQ-LGTIIVSGSTEKVLRVWDPRTC-AKLMKLKGHTDNVKALLLNRD-GTQ 224 Query: 120 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM 153 LS S DG+I++WS +++ + T + + Sbjct: 225 CLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWAL 258 Score = 33.3 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 34/97 (35%), Gaps = 16/97 (16%) Query: 277 EIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF 336 E+ + + + P N L +A D RIW + + D S+ Sbjct: 24 EVEKYNRNGVNALQLDP-ALNRLFTAGRDSIIRIW----------SVNQHKQDPYIASM- 71 Query: 337 NFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 H+++V GK + S + D + VWN Sbjct: 72 --EHHTDWVNDIVLCCNGKT--LISASSDTTVKVWNA 104 >6GMH-W nrPDB Length = 305 Score = 74.9 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 44/294 (14%), Positives = 103/294 (35%), Gaps = 50/294 (17%) Query: 61 DCLFDLAWNES---HENQVLVAQGDGTLRLFDTTFKEFPI-AIFKEHEREVFSCNWNLVN 116 D ++ +AW + + V+ D ++++ + + + H+ V S + + Sbjct: 17 DAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTL 76 Query: 117 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNC 176 SSS D I++W + + ++ P++ + ++ L + G Sbjct: 77 P-IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGV 135 Query: 177 ---------------VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGL 221 + +SP + L S + + ++FDI +GK + H + Sbjct: 136 ESGKKEYSLDTRGKFILSIAYSPDGKYL-ASGAIDGIINIFDIA--TGKLLHTLEGH-AM 191 Query: 222 EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRT-------VPGQLH---- 270 + F+ ++ T D I+I+D++ N + + + P H Sbjct: 192 PIRSLTFSP-DSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSS 250 Query: 271 ------------NSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 312 +C++ + H + V ++ + S I +S D I+ Sbjct: 251 SSDKSVKVWDVGTRTCVHTFFD-HQDQVWGVKYNGNGSKI-VSVGDDQEIHIYD 302 >6BX3-A nrPDB Length = 314 Score = 74.9 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 48/315 (15%), Positives = 99/315 (31%), Gaps = 54/315 (17%) Query: 59 TQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQ 118 TQ+ L S + Q L + ++D + + H R W+ Q Sbjct: 9 TQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD-GQ 67 Query: 119 NFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVY 178 ++S D S++I + P+ ++ +K Sbjct: 68 CIATASDDFSVEI--------IHLSYGLLHTFIGHTAPVISLTFNRKG------------ 107 Query: 179 QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVAT 238 NL+ + S + ++D +G HS ++ D ++++ Sbjct: 108 ---------NLLFTSSMDESIKIWDT--LNGSLMKTISAHSEA-VVSVDVPMNDSSILSS 155 Query: 239 GGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNI 298 G D IRI+D + +T+ +P I +V +S ++ Sbjct: 156 GSYDGLIRIFDAE------TGHCLKTLTYDKDWKRENGVVP------ISQVKFS-ENARY 202 Query: 299 LMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGY 358 L+ S D +IW + + + + + +F+ G Sbjct: 203 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKG----VLHHSCGMDFLN----PEDGSTPL 254 Query: 359 VASTAWDGNLFVWNG 373 V S +G+++ WN Sbjct: 255 VISGYENGDIYCWNS 269 Score = 63.8 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 37/213 (17%), Positives = 77/213 (36%), Gaps = 36/213 (16%) Query: 163 KKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLE 222 + S T ++ + + +SP Q + + S + + + + F+ H Sbjct: 43 RTVSQTLVTSHARPFSELCWSPDGQC-IATASDDFSVEIIHLSYGL---LHTFIGH-TAP 97 Query: 223 ALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAH 282 ++ FN + ++ T +D +I+IWD + ++ + AH Sbjct: 98 VISLTFN-RKGNLLFTSSMDESIKIWDTLNGSLMKTIS--------------------AH 136 Query: 283 GLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHS 342 A+ V + S+IL S SYD RI+ + K G + Sbjct: 137 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV------- 189 Query: 343 EFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG 375 + +S + Y+ + DG + +W+ +G Sbjct: 190 -PISQVKFSENAR--YLLVKSLDGVVKIWDCIG 219 Score = 61.1 bits (146), Expect = 8e-10, Method: Composition-based stats. Identities = 39/266 (14%), Positives = 87/266 (32%), Gaps = 48/266 (18%) Query: 54 VNSFLTQDC-LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNW 112 +++F+ + L +N N + + D +++++D T + H V S + Sbjct: 88 LHTFIGHTAPVISLTFNR-KGNLLFTSSMDESIKIWD-TLNGSLMKTISAHSEAVVSVDV 145 Query: 113 NLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISK 172 + + S S+DG I+I+ L TLT + + + Sbjct: 146 PMNDSSILSSGSYDGLIRIFDAETGHCLKTLT-YDKDWKRENGVVP-------------- 190 Query: 173 NRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI------RLPSGKNQNNFLVHSGLEALTC 226 + Q +FS + + L++ S + ++D R + ++H Sbjct: 191 ----ISQVKFSENARYLLVK-SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 245 Query: 227 DFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAI 286 + +V +G + I W+ ++ H + Sbjct: 246 NPEDGSTPLVISGYENGDIYCWN----------------SDTKSLLQLLDGSLYHHSSPV 289 Query: 287 RKVTWSPHHSNILMSASYDMTCRIWR 312 + NI+ S + + C +WR Sbjct: 290 MSIHCF---GNIMCSLALNGDCCLWR 312 >5Y88-O nrPDB Length = 451 Score = 74.9 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 70/222 (31%), Gaps = 53/222 (23%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 + H V + V+ + F++ S D ++K+W + TL Sbjct: 134 VINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTL--------------- 178 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH 218 + + V S L S S + +D+ + ++ H Sbjct: 179 ------------AGHVMTVRDVAVSDRHPYLF-SVSEDKTVKCWDLEKN--QIIRDYYGH 223 Query: 219 SGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 T + ++AT G D+ I++WD+R Sbjct: 224 LSG-VRTVSIHPTLD-LIATAGRDSVIKLWDMRT--------------------RIPVIT 261 Query: 279 PNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAK 320 H I +V +P ++S+S D T R+W ++ K Sbjct: 262 LVGHKGPINQVQCTPVD-PQVVSSSTDATVRLWDVVAGKTMK 302 Score = 67.6 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 38/265 (14%), Positives = 87/265 (32%), Gaps = 36/265 (13%) Query: 74 NQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWS 133 + D T++ +D K I + H V + + + ++ D IK+W Sbjct: 195 PYLFSVSEDKTVKCWDLE-KNQIIRDYYGHLSGVRTVSIHPTLD-LIATAGRDSVIKLWD 252 Query: 134 PLRKQSLMTLTPRPLEITKM----VDPLNAI-----------ILKKKSFTGISKNRNCVY 178 + ++TL I ++ VDP ++ K+ ++ ++ V Sbjct: 253 MRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVR 312 Query: 179 QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVAT 238 P + ++ +C+ + + + G NF T N + V+ Sbjct: 313 ATALHPKEFSVASACTDD--IRSWGLA--EGSLLTNFESEKTGIINTLSIN--QDDVLFA 366 Query: 239 GGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNI 298 GG + + +D + +K +S + V ++ T+ Sbjct: 367 GGDNGVLSFYDYKSGHKYQSLATREMVGSLEG------------ERSVLCSTFDKTGLR- 413 Query: 299 LMSASYDMTCRIWRDLSNDGAKETY 323 L++ D + +IW+ + Sbjct: 414 LITGEADKSIKIWKQDETATKESEP 438 Score = 44.1 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 31/202 (15%), Positives = 64/202 (31%), Gaps = 27/202 (13%) Query: 178 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVA 237 Y A PH Q+ + S +D + + L+ + DF++ V++ Sbjct: 29 YMATLPPHLQSEME--GQKSLLMRYDTYRKESSSFSGEGKKVTLQHVPTDFSEASQAVIS 86 Query: 238 TGGVDNAI-----RIWDIRMLNKNESATIKRTVPGQL--HNSSCINEIPNAHGLAIRKVT 290 D +I+ + + ++ + + H ++ + N H +R V Sbjct: 87 KKDHDTHASAFVNKIFQPEVAEELIVNRYEKLLSQRPEWHAPWKLSRVINGHLGWVRCVA 146 Query: 291 WSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADW 350 P + ++ S D T ++W + H V Sbjct: 147 IDPVDNEWFITGSNDTTMKVWDLATGKLKTTLA----------------GHVMTVRDVAV 190 Query: 351 SLWGKPGYVASTAWDGNLFVWN 372 S P Y+ S + D + W+ Sbjct: 191 S-DRHP-YLFSVSEDKTVKCWD 210 >3JAP-g nrPDB Length = 326 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 46/323 (14%), Positives = 99/323 (30%), Gaps = 56/323 (17%) Query: 52 VEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCN 111 V V S+ + + N + A D TLRL++ A F H +V S Sbjct: 57 VPVRSYKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSE-ARFVGHTGDVLSVA 115 Query: 112 WNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGIS 171 + N +S+S D +I++W+ + L D + + + K+ Sbjct: 116 IDA-NSSKIISASRDKTIRVWNTV-GDCAYVLLGH-------TDWVTKVRVAPKNLEDGE 166 Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKY 231 + + +S + + + S + + +F+ H+ + Sbjct: 167 VDDGRI-----------TFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNY-INVVQPSP- 213 Query: 232 RPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTW 291 + A+ G D I +W+++ + + K + + + Sbjct: 214 DGSLAASAGKDGQIYVWNLKHKSAFMNFDAK---------------------DEVFALAF 252 Query: 292 SPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 351 SP S ++A+ +I+ + E WS Sbjct: 253 SP--SRFWLTAATASGIKIYDLENEVLIDELK--------PEFAGYTKAQDPHAVSLAWS 302 Query: 352 LWGKPGYVASTAWDGNLFVWNGL 374 G+ + + D + VW + Sbjct: 303 ADGQTLF--AGYTDNVIRVWQVM 323 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 91/283 (32%), Gaps = 73/283 (25%) Query: 99 IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 158 + H V S + + +S S D ++ W ++ + Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISW-------------------RLTENEQ 53 Query: 159 AIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH 218 + +S+ G S + V S V S S + L+++ +G ++ F+ H Sbjct: 54 QFGVPVRSYKGHS---HIVQDVVVSADGNYAV-SASWDKTLRLWNLA--TGNSEARFVGH 107 Query: 219 SGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 +G + L+ + ++ + D IR+W+ C + Sbjct: 108 TG-DVLSVAIDANSSKII-SASRDKTIRVWN--------------------TVGDCAYVL 145 Query: 279 PNAHGLAIRKVTWSP---------HHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTD 329 H + KV +P +SA D R W +++Y+ + Sbjct: 146 L-GHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSL-----NEDSYRIEAD- 198 Query: 330 ATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 F H+ ++ S G AS DG ++VWN Sbjct: 199 --------FIGHNNYINVVQPSPDGS--LAASAGKDGQIYVWN 231 Score = 44.9 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 23/98 (23%), Positives = 34/98 (34%), Gaps = 13/98 (13%) Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 334 + H + ++ S N+L+S S D T WR N Sbjct: 10 LRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTEN-----------EQQFGVP 58 Query: 335 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + ++ HS V S G Y S +WD L +WN Sbjct: 59 VRSYKGHSHIVQDVVVSADGN--YAVSASWDKTLRLWN 94 >3BG0-A nrPDB Length = 316 Score = 73.0 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 50/308 (16%), Positives = 102/308 (33%), Gaps = 50/308 (16%) Query: 73 ENQVLVAQGDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNW-NLVNRQNFLSSSWDGSIK 130 ++ D ++++FD + IA + HE V+ W + + S S+D + Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 190 IW + + + + V ++PHD L+ Sbjct: 85 IWREENGTWEKSHE-------------------------HAGHDSSVNSVCWAPHDYGLI 119 Query: 191 LS-CSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAI--RI 247 L+ S + SL +G+ Q + + C+ + P VV +D+ + Sbjct: 120 LACGSSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKP 176 Query: 248 WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH---HSNILMSASY 304 I+ + + + + AH +R V W+P ++ + S S Sbjct: 177 NYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 Query: 305 DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAW 364 D IW +S + + F ++ V+ WS+ +A + Sbjct: 237 DGRVFIW---------TCDDASSNTWSPKLLHKF---NDVVWHVSWSITAN--ILAVSGG 282 Query: 365 DGNLFVWN 372 D + +W Sbjct: 283 DNKVTLWK 290 Score = 53.4 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 36/211 (17%), Positives = 67/211 (31%), Gaps = 24/211 (11%) Query: 166 SFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALT 225 T + + + ++ AQ + + +CS + +FD+R + H G Sbjct: 5 INTVDTSHEDMIHDAQMDYYG-TRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQV 63 Query: 226 CDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLA 285 + ++A+ D + IW +S H + Sbjct: 64 AWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHA------------------GHDSS 105 Query: 286 IRKVTWSPHH-SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEF 344 + V W+PH IL S D + + +G E K N+ + ++ Sbjct: 106 VNSVCWAPHDYGLILACGSSDGAISL-LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVP 164 Query: 345 VFGADWSLWGKPGYV---ASTAWDGNLFVWN 372 D KP Y+ AS D + +W Sbjct: 165 GSLIDHPSGQKPNYIKRFASGGCDNLIKLWK 195 Score = 44.5 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 32/253 (12%), Positives = 74/253 (29%), Gaps = 46/253 (18%) Query: 42 ILEIDRSGRIVEVNSFLTQDCLFDLAW-NESHENQVLVAQGDGTLRLF-DTTFKEFPIAI 99 I ++ G+I+ + + ++ +AW + + N + D + ++ + Sbjct: 39 IFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHE 98 Query: 100 FKEHEREVFSCNWNL-VNRQNFLSSSWDGSIKI--------WSPLRKQSLMTLTPRPLEI 150 H+ V S W S DG+I + W + + T+ Sbjct: 99 HAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTI-GCNAVS 157 Query: 151 TKMVDPLNAIILKK-------------------------------KSFTGISKNRNCVYQ 179 ++I K + + + V Sbjct: 158 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 217 Query: 180 AQFSP---HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVV 236 ++P + + SCS + ++ S + L+H + + ++ Sbjct: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANIL 277 Query: 237 ATGGVDNAIRIWD 249 A G DN + +W Sbjct: 278 AVSGGDNKVTLWK 290 >6ELZ-p nrPDB Length = 460 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 51/354 (14%), Positives = 103/354 (29%), Gaps = 81/354 (22%) Query: 54 VNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWN 113 +NSF +D + L + ++ DG +R +D + + H + + + Sbjct: 97 LNSFSNEDWVSSLDVGDG-SKHIISGSYDGIVRTWDLS--GNVQKQYSGHSGPIRAVKYI 153 Query: 114 LVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 173 R +S+ D ++++W +T + + D I K+ + + Sbjct: 154 SNTR--LVSAGNDRTLRLWKTKNDDLKLT----SQQQAQEDDDDEVNIEDGKTLAILEGH 207 Query: 174 RNCVYQAQFSPHDQNLVLSCSGNSYASLF--------------DIRLPSGK--------- 210 + V D + +LS S ++ + DI P+ K Sbjct: 208 KAPV--VSIDVSDNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRR 265 Query: 211 ------------NQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNES 258 + L F+ V + D+ I+ WD+ Sbjct: 266 KLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDL----VTAR 321 Query: 259 ATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDG 318 RT L + + ++ + N+L S + Sbjct: 322 CIDTRTTSYSLLSIAQLSTL------------------NLLACGSSARHITLHDPRVGAS 363 Query: 319 AKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 +K T + H FV D + + S + DG + VW+ Sbjct: 364 SKVTQQQLI------------GHKNFVSSLDTCPENE-YILCSGSHDGTVKVWD 404 Score = 40.7 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 35/101 (34%), Gaps = 4/101 (3%) Query: 71 SHENQVLVAQGDGTLRLFDT---TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDG 127 S N + + L D + H+ V S + N S S DG Sbjct: 339 STLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDG 398 Query: 128 SIKIWSPLRKQSLMTLTPRPLEITK-MVDPLNAIILKKKSF 167 ++K+W + T+T + K + D + A+ +K Sbjct: 399 TVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVG 439 >5WYJ-BC nrPDB Length = 817 Score = 72.3 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 44/308 (14%), Positives = 101/308 (32%), Gaps = 72/308 (23%) Query: 76 VLVAQGDGTLRLF---------DTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWD 126 +L A D T++ + D + HE+++ + + N F ++S+D Sbjct: 454 LLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSV-SPNDSIFATASYD 512 Query: 127 GSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHD 186 + KIW+ + TL + + C Y Sbjct: 513 KTCKIWNLENGELEATLANHKRGLWDVSF--------------------CQYD------- 545 Query: 187 QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIR 246 L+ + SG+ ++ L + H+ NK + + + G D I+ Sbjct: 546 -KLLATSSGDKTVKIW--SLDTFSVMKTLEGHTNAVQRCSFINKQKQLI--SCGADGLIK 600 Query: 247 IWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDM 306 IWD + C+ + + H + ++ + + ++++SA D Sbjct: 601 IWD-------------------CSSGECLKTL-DGHNNRLWALS-TMNDGDMIVSADADG 639 Query: 307 TCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDG 366 + W+D + +E + + ++ DW+ ++ + D Sbjct: 640 VFQFWKDCTEQEIEEEQEKAKLQVEQEQSLQ-----NYMSKGDWT----NAFLLAMTLDH 690 Query: 367 NLFVWNGL 374 + ++N L Sbjct: 691 PMRLFNVL 698 Score = 63.8 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 42/94 (44%), Gaps = 3/94 (3%) Query: 62 CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFL 121 L+D+++ + ++ + + GD T++++ + + H V C++ + ++ + Sbjct: 535 GLWDVSFCQ-YDKLLATSSGDKTVKIWSLDTFSV-MKTLEGHTNAVQRCSF-INKQKQLI 591 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVD 155 S DG IKIW + L TL + + Sbjct: 592 SCGADGLIKIWDCSSGECLKTLDGHNNRLWALST 625 Score = 48.8 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 48/370 (12%), Positives = 108/370 (29%), Gaps = 92/370 (24%) Query: 76 VLVAQGDGTLRLFDTTFKEFPIAIFKEH-EREVFSCNWNLVNRQN--FLSSSWDGSIKIW 132 +L D + L+D K+ + ++V SC + ++ D ++ Sbjct: 211 LLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLI 270 Query: 133 SPLRK-------------------------QSLMTLTPRPLEITKMVDPLNAIILKKKSF 167 Q + L+ + L++ + + L + Sbjct: 271 DSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVT 330 Query: 168 TGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLF---DIRLPSGKNQNNFLVHSGLEAL 224 + I+ N + ++ + N + + + + D+ P + ++ G E L Sbjct: 331 SSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDL 390 Query: 225 TCDFNKYRPYV-VATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPN--- 280 + + +AT DN +W + K + + I + Sbjct: 391 LNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGY 450 Query: 281 --------------------------------------AHGLAIRKVTWSPHHSNILMSA 302 AH I ++ SP+ S I +A Sbjct: 451 PEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDS-IFATA 509 Query: 303 SYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVAST 362 SYD TC+IW + + H ++ + + K +A++ Sbjct: 510 SYDKTCKIWNLENGELEATLAN----------------HKRGLWDVSFCQYDK--LLATS 551 Query: 363 AWDGNLFVWN 372 + D + +W+ Sbjct: 552 SGDKTVKIWS 561 Score = 41.8 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 74/245 (30%), Gaps = 27/245 (11%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIA--IFKEHEREVFSCNWNLVNRQNFLSSSWDGS 128 S ++L + + D T I I E E+E+ + Q S Sbjct: 26 SENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPD-GQYLTYVSQAQL 84 Query: 129 IKIWSPLRKQSLMTLTPRPLEITKMVDPLNAI--------------ILKKKSFTGISKNR 174 +KI+ + + ++ D + + I + Sbjct: 85 LKIFHLKTGKVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHG 144 Query: 175 NCVYQAQFSPHDQN---LVLSCSGNSYASLFDI--RLPSGKNQNNFLVHSGLEALTCDFN 229 + +F + L+ S N ++D+ R Q + GL+ + N Sbjct: 145 GTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDN 204 Query: 230 KYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVP-----GQLHNSSCINEIPNAHGL 284 + +GG D+ I +WD M K + G L + I A G Sbjct: 205 DEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGD 264 Query: 285 AIRKV 289 AI ++ Sbjct: 265 AIFQL 269 >5OQL-L nrPDB Length = 557 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 45/298 (15%), Positives = 97/298 (32%), Gaps = 62/298 (20%) Query: 24 LAVAAGSN--FGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQG 81 L AA +N F + ++ I I + + + F D ++ + Sbjct: 63 LVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRF---DSEAHCGEIRPDGRVLVAGED 119 Query: 82 DGTLRLFDTT--FKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQS 139 G +++FD + + + H++ V+ W+ +S S D ++++W Sbjct: 120 TGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDL----- 174 Query: 140 LMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP--HDQNLVLSCSGNS 197 DP + + + V F P + NL++S S + Sbjct: 175 ------------PSNDPTRLF----------TGHTDYVRCGAFMPGSANSNLLVSGSYDE 212 Query: 198 YASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNE 257 ++D R P G F +E + ++A G NAI + D+ Sbjct: 213 TVRVWDARAPGGAVM-TFKHADPIEDVLPL--PSGTTLLAASG--NAISVLDL------- 260 Query: 258 SATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLS 315 ++ + H + ++ + ++S S D +++ S Sbjct: 261 -------------VAAKPLRLITNHQKTVTSLSLASQG-RRVVSGSLDGHVKVFETTS 304 Score = 62.6 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 42/266 (15%), Positives = 83/266 (31%), Gaps = 48/266 (18%) Query: 134 PLRKQSLMTLTPRPLEITKMVDPLNAI--ILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 191 L SL+ P I I K++ I + + + + P + +++ Sbjct: 57 ALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGR-VLV 115 Query: 192 SCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 251 + +FD+ + ++ + + D +R+WD+ Sbjct: 116 AGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLP 175 Query: 252 MLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP--HHSNILMSASYDMTCR 309 + T H +R + P +SN+L+S SYD T R Sbjct: 176 SNDPTRLFT--------------------GHTDYVRCGAFMPGSANSNLLVSGSYDETVR 215 Query: 310 IWRDLSNDGAKETYKTNS--TDATK----GSIFNFTQHSEFVFG---------------- 347 +W + GA T+K D ++ + ++ V Sbjct: 216 VWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGNAISVLDLVAAKPLRLITNHQKT 275 Query: 348 -ADWSLWGKPGYVASTAWDGNLFVWN 372 SL + V S + DG++ V+ Sbjct: 276 VTSLSLASQGRRVVSGSLDGHVKVFE 301 Score = 55.3 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 45/126 (35%), Gaps = 17/126 (13%) Query: 249 DIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTC 308 D R+L E + + I + + H + WSP LMS S D T Sbjct: 110 DGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTV 169 Query: 309 RIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG-KPGYVASTAWDGN 367 R+W SND + FT H+++V + + S ++D Sbjct: 170 RLWDLPSNDPTR----------------LFTGHTDYVRCGAFMPGSANSNLLVSGSYDET 213 Query: 368 LFVWNG 373 + VW+ Sbjct: 214 VRVWDA 219 >4G56-B nrPDB Length = 357 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 34/285 (11%), Positives = 74/285 (25%), Gaps = 50/285 (17%) Query: 45 IDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHE 104 +++ +V + D + S Q + D +++++D + ++ + + H Sbjct: 123 LEKESLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLS-QKAVLKSYNAHS 181 Query: 105 REVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKK 164 EV FLS DG I +W + K Sbjct: 182 SEVNCVAACPGKDTIFLSCGEDGRILLWDTRKP-------------------------KP 216 Query: 165 KSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEAL 224 + + + P + SL +I+ P + Sbjct: 217 ATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTS---AVHSQNIT 273 Query: 225 TCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGL 284 ++ + +A+ D + + D +H Sbjct: 274 GLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDL---------------------SHRD 312 Query: 285 AIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTD 329 + V WSP + + +D S + T + D Sbjct: 313 FVTGVAWSPLDHSKFTTVGWDHKVLHHHLPSEGRTENLIATKAED 357 Score = 48.0 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 25/171 (14%), Positives = 48/171 (28%), Gaps = 23/171 (13%) Query: 168 TGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCD 227 T + V + LV S + L++I N F + + + Sbjct: 88 TAGVQTEAGVTDVAWVSEKGILV--ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTL 145 Query: 228 FNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIR 287 +GG D ++++WD+ + + + NAH + Sbjct: 146 SVFSDGTQAVSGGKDFSVKVWDL--------------------SQKAVLKSYNAHSSEVN 185 Query: 288 KVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNF 338 V P I +S D +W ++D S+ Sbjct: 186 CVAACPGKDTIFLSCGEDGRILLWDTRKPK-PATRIDFCASDTIPTSVTWH 235 >5G04-R nrPDB Length = 499 Score = 69.9 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 46/320 (14%), Positives = 102/320 (31%), Gaps = 60/320 (18%) Query: 72 HENQVLVAQGDGTLRLFDTTFKE-FPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 VL D ++ L+ + + + ++ + S W + + ++ Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW-IKEGNYLAVGTSSAEVQ 251 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPL--------------NAIILKKKSFTGISKNRNC 176 +W +++ L +T + + + + + + +S + Sbjct: 252 LWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 311 Query: 177 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQN-NFLVHSGLEALTCDFNKYRPYV 235 V +++P ++L S ++ +++ G + ++ V Sbjct: 312 VCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 370 Query: 236 VATGG--VDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP 293 +ATGG D IRIW++ + +C+ +AH + + WSP Sbjct: 371 LATGGGTSDRHIRIWNV-------------------CSGACL-SAVDAHS-QVCSILWSP 409 Query: 294 HHSNILMSASY-DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSL 352 H+ ++ + IW+ + E H+ V S Sbjct: 410 HYKELISGHGFAQNQLVIWKYPTMAKVAEL----------------KGHTSRVLSLTMSP 453 Query: 353 WGKPGYVASTAWDGNLFVWN 372 G VAS A D L +W Sbjct: 454 DGAT--VASAAADETLRLWR 471 Score = 64.9 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 44/275 (16%), Positives = 90/275 (32%), Gaps = 55/275 (20%) Query: 65 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSS 124 L+WN + G + D E +A H +EV W + ++ S Sbjct: 273 SLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW-APDGRHLASGG 328 Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 D + +W + PL ++++ V + P Sbjct: 329 NDNLVNVWPSAPGEGGWV-------------PLQTF----------TQHQGAVKAVAWCP 365 Query: 185 HDQNLVLSCSG--NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVAT-GGV 241 N++ + G + + ++++ SG + HS + + ++ + +++ G Sbjct: 366 WQSNVLATGGGTSDRHIRIWNV--CSGACLSAVDAHS--QVCSILWSPHYKELISGHGFA 421 Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMS 301 N + IW + K H + +T SP + + S Sbjct: 422 QNQLVIWKYPTMAKVAE--------------------LKGHTSRVLSLTMSPDGATV-AS 460 Query: 302 ASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF 336 A+ D T R+WR D A+ + ++ A I Sbjct: 461 AAADETLRLWRCFELDPARRREREKASAAKSSLIH 495 >4GGA-A nrPDB Length = 420 Score = 69.2 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 46/320 (14%), Positives = 102/320 (31%), Gaps = 60/320 (18%) Query: 72 HENQVLVAQGDGTLRLFDTTFKE-FPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 VL D ++ L+ + + + ++ + S W + + ++ Sbjct: 114 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW-IKEGNYLAVGTSSAEVQ 172 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPL--------------NAIILKKKSFTGISKNRNC 176 +W +++ L +T + + + + + + +S + Sbjct: 173 LWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 232 Query: 177 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQN-NFLVHSGLEALTCDFNKYRPYV 235 V +++P ++L S ++ +++ G + ++ V Sbjct: 233 VCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 291 Query: 236 VATGG--VDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP 293 +ATGG D IRIW++ + +C+ +AH + + WSP Sbjct: 292 LATGGGTSDRHIRIWNV-------------------CSGACL-SAVDAHS-QVCSILWSP 330 Query: 294 HHSNILMSASY-DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSL 352 H+ ++ + IW+ + E H+ V S Sbjct: 331 HYKELISGHGFAQNQLVIWKYPTMAKVAEL----------------KGHTSRVLSLTMSP 374 Query: 353 WGKPGYVASTAWDGNLFVWN 372 G VAS A D L +W Sbjct: 375 DGAT--VASAAADETLRLWR 392 Score = 64.2 bits (154), Expect = 8e-11, Method: Composition-based stats. Identities = 44/275 (16%), Positives = 90/275 (32%), Gaps = 55/275 (20%) Query: 65 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSS 124 L+WN + G + D E +A H +EV W + ++ S Sbjct: 194 SLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW-APDGRHLASGG 249 Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 D + +W + PL ++++ V + P Sbjct: 250 NDNLVNVWPSAPGEGGWV-------------PLQTF----------TQHQGAVKAVAWCP 286 Query: 185 HDQNLVLSCSG--NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVAT-GGV 241 N++ + G + + ++++ SG + HS + + ++ + +++ G Sbjct: 287 WQSNVLATGGGTSDRHIRIWNV--CSGACLSAVDAHS--QVCSILWSPHYKELISGHGFA 342 Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMS 301 N + IW + K H + +T SP + + S Sbjct: 343 QNQLVIWKYPTMAKVAE--------------------LKGHTSRVLSLTMSPDGATV-AS 381 Query: 302 ASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF 336 A+ D T R+WR D A+ + ++ A I Sbjct: 382 AAADETLRLWRCFELDPARRREREKASAAKSSLIH 416 >5WYK-BB nrPDB Length = 943 Score = 69.2 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 115/320 (35%), Gaps = 54/320 (16%) Query: 21 DNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQ 80 DN+L +A SN G+ K++ ++ + R E LT V++ Sbjct: 402 DNKL-LATASN----GSLKIWNIKTHKCIRTFECGYALT-------CKFLPGGLLVILGT 449 Query: 81 GDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSL 140 +G L+LFD I H+ ++S + + ++ S D ++K W + SL Sbjct: 450 RNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSD-GKRLVTGSADKTVKFWDFKVENSL 508 Query: 141 MTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYAS 200 + T L + L + + + + SP D+ L +S ++ Sbjct: 509 VPGTKNKF--------LPVLKLH---HDTTLELTDDILCVRVSPDDRYLAISL-LDNTVK 556 Query: 201 LFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI------RMLN 254 +F L L L+ D + ++ T D I+IW + + L Sbjct: 557 VF---FLDSMKFYLSLYGHKLPVLSIDI-SFDSKMIITSSADKNIKIWGLDFGDCHKSLF 612 Query: 255 KNESATIKRTVPGQLHNS-----------------SCINEIPNAHGLAIRKVTWSPHHSN 297 ++ + + Q HN CI ++ AH + + + Sbjct: 613 AHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKL-YAHQSEVWALAVA-TDGG 670 Query: 298 ILMSASYDMTCRIWRDLSND 317 ++S+S+D + RIW + + Sbjct: 671 FVVSSSHDHSIRIWEETEDQ 690 Score = 60.7 bits (145), Expect = 9e-10, Method: Composition-based stats. Identities = 41/254 (16%), Positives = 85/254 (33%), Gaps = 47/254 (18%) Query: 59 TQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQ 118 +C + A + + V DG ++++D K + F H+ + ++ Sbjct: 79 PAECTYLEA--HKDTDLLAVGYADGVIKVWDLMSKTV-LLNFNGHKAAITLLQFDGT-GT 134 Query: 119 NFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVY 178 +S S D +I +W + + L L IT Sbjct: 135 RLISGSKDSNIIVWDLVGEVGLYKLRSHKDSIT--------------------------- 167 Query: 179 QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVAT 238 F ++ ++S S + L+D L + + + H+G C + ++ T Sbjct: 168 --GFWCQGEDWLISTSKDGMIKLWD--LKTHQCIETHIAHTGE----CWGLAVKDDLLIT 219 Query: 239 GGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNI 298 G D+ ++IW + + N + + + GL I +T S ++ Sbjct: 220 TGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQ--------RGLKIEFITNSSDKTSF 271 Query: 299 LMSASYDMTCRIWR 312 + D T +R Sbjct: 272 FYIQNADKTIETFR 285 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 47/273 (17%), Positives = 87/273 (31%), Gaps = 60/273 (21%) Query: 100 FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNA 159 + +V S + + N L+++ +GS+KIW+ + + T K Sbjct: 387 LQGQRTDVRSIDISDDN--KLLATASNGSLKIWNIKTHKCIRTFECGYALTCK------- 437 Query: 160 IILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHS 219 I RN Q F +L+ + A+++ + L S Sbjct: 438 --FLPGGLLVILGTRNGELQL-FDLASSSLLDTIEDAHDAAIWSLDLTS----------- 483 Query: 220 GLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPG-QLHNSSCINEI 278 + TG D ++ WD ++ N T + +P +LH+ + + Sbjct: 484 ------------DGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLEL- 530 Query: 279 PNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNF 338 I V SP L + D T +++ S Y Sbjct: 531 ----TDDILCVRVSPDD-RYLAISLLDNTVKVFFLDSMKFYLSLY--------------- 570 Query: 339 TQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 H V D S K + +++ D N+ +W Sbjct: 571 -GHKLPVLSIDISFDSK--MIITSSADKNIKIW 600 Score = 57.6 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 36/260 (13%), Positives = 76/260 (29%), Gaps = 63/260 (24%) Query: 113 NLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISK 172 N ++S+ + + IW + L+ +A K T + Sbjct: 34 NGSGPGQLITSALED-VNIWDIKTGDLVSKLSDG-----LPPGASDARGAKPAECTYLEA 87 Query: 173 NRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYR 232 ++ D +L+ + ++D+ + NF H L F+ Sbjct: 88 HK-----------DTDLLAVGYADGVIKVWDLMSKT--VLLNFNGHKAAITL-LQFDGTG 133 Query: 233 PYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWS 292 ++ +G D+ I +WD+ +H +I + Sbjct: 134 TRLI-SGSKDSNIIVWDL--------------------VGEVGLYKLRSHKDSITG--FW 170 Query: 293 PHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSL 352 + L+S S D ++W ++ + H+ G W L Sbjct: 171 CQGEDWLISTSKDGMIKLWDLKTHQCIET----------------HIAHT----GECWGL 210 Query: 353 WGKPGYVASTAWDGNLFVWN 372 K + +T D + +W Sbjct: 211 AVKDDLLITTGTDSQVKIWK 230 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 42/302 (13%), Positives = 96/302 (31%), Gaps = 39/302 (12%) Query: 37 NGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFD------- 89 NG+L + ++ S + + D S +++ D T++ +D Sbjct: 451 NGELQLFDLASSSLLDTIED--AHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSL 508 Query: 90 ---TTFKEFPIAIFKEH-----EREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLM 141 T K P+ ++ + +R S D ++K++ + + Sbjct: 509 VPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDR-YLAISLLDNTVKVFFLDSMKFYL 567 Query: 142 TLTPRPLEITKMVDPLNAIILKKKS---------------FTGISKNRNCVYQAQFSPHD 186 +L L + + ++ ++ S + +++ + +F P Sbjct: 568 SLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQS 627 Query: 187 QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIR 246 N SCS ++ +D Q + S + AL V + D++IR Sbjct: 628 HNFF-SCSKDAVVKYWDGEKFECI-QKLYAHQSEVWALAV---ATDGGFVVSSSHDHSIR 682 Query: 247 IWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDM 306 IW+ ++ K + + + + + +G K S S + Sbjct: 683 IWE-ETEDQVFLEEEKEKELEEQYEDTLLTSLEEGNGDDAFKADASGEGVEDEASGVHKQ 741 Query: 307 TC 308 T Sbjct: 742 TL 743 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 50/152 (32%), Gaps = 5/152 (3%) Query: 55 NSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNL 114 + F QD + ++ + N D ++ +D E I H+ EV++ Sbjct: 610 SLFAHQDSIMNVKFLPQSHN-FFSCSKDAVVKYWDGEKFEC-IQKLYAHQSEVWALAV-A 666 Query: 115 VNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNR 174 + +SSS D SI+IW Q + + D L + + + Sbjct: 667 TDGGFVVSSSHDHSIRIWEETEDQVFLEEEKEKELEEQYEDTLLTSLEEGNGDDAFKADA 726 Query: 175 N--CVYQAQFSPHDQNLVLSCSGNSYASLFDI 204 + V H Q L +G D+ Sbjct: 727 SGEGVEDEASGVHKQTLESLKAGERLMEALDL 758 Score = 41.0 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 21/145 (14%), Positives = 43/145 (29%), Gaps = 33/145 (22%) Query: 233 PYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSS--CINEIPNAHGLAIRKVT 290 ++ + D + IWDI+ + + + AH Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKD------ 90 Query: 291 WSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADW 350 +++L D ++W +S + NF H + + Sbjct: 91 -----TDLLAVGYADGVIKVWDLMSK----------------TVLLNFNGHKAAITLLQF 129 Query: 351 SLWGKPGYVASTAWDGNLFVWNGLG 375 G + S + D N+ VW+ +G Sbjct: 130 --DGTGTRLISGSKDSNIIVWDLVG 152 >5LCW-Q nrPDB Length = 374 Score = 69.2 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 46/320 (14%), Positives = 102/320 (31%), Gaps = 60/320 (18%) Query: 72 HENQVLVAQGDGTLRLFDTTFKE-FPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 VL D ++ L+ + + + ++ + S W + + ++ Sbjct: 68 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW-IKEGNYLAVGTSSAEVQ 126 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPL--------------NAIILKKKSFTGISKNRNC 176 +W +++ L +T + + + + + + +S + Sbjct: 127 LWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 186 Query: 177 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQN-NFLVHSGLEALTCDFNKYRPYV 235 V +++P ++L S ++ +++ G + ++ V Sbjct: 187 VCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 245 Query: 236 VATGG--VDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP 293 +ATGG D IRIW++ + +C+ +AH + + WSP Sbjct: 246 LATGGGTSDRHIRIWNV-------------------CSGACL-SAVDAHS-QVCSILWSP 284 Query: 294 HHSNILMSASY-DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSL 352 H+ ++ + IW+ + E H+ V S Sbjct: 285 HYKELISGHGFAQNQLVIWKYPTMAKVAEL----------------KGHTSRVLSLTMSP 328 Query: 353 WGKPGYVASTAWDGNLFVWN 372 G VAS A D L +W Sbjct: 329 DGAT--VASAAADETLRLWR 346 Score = 64.2 bits (154), Expect = 9e-11, Method: Composition-based stats. Identities = 44/275 (16%), Positives = 90/275 (32%), Gaps = 55/275 (20%) Query: 65 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSS 124 L+WN + G + D E +A H +EV W + ++ S Sbjct: 148 SLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW-APDGRHLASGG 203 Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 D + +W + PL ++++ V + P Sbjct: 204 NDNLVNVWPSAPGEGGWV-------------PLQTF----------TQHQGAVKAVAWCP 240 Query: 185 HDQNLVLSCSG--NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVAT-GGV 241 N++ + G + + ++++ SG + HS + + ++ + +++ G Sbjct: 241 WQSNVLATGGGTSDRHIRIWNV--CSGACLSAVDAHS--QVCSILWSPHYKELISGHGFA 296 Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMS 301 N + IW + K H + +T SP + + S Sbjct: 297 QNQLVIWKYPTMAKVAE--------------------LKGHTSRVLSLTMSPDGATV-AS 335 Query: 302 ASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF 336 A+ D T R+WR D A+ + ++ A I Sbjct: 336 AAADETLRLWRCFELDPARRREREKASAAKSSLIH 370 >4OWR-A nrPDB Length = 339 Score = 68.8 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 52/317 (16%), Positives = 100/317 (31%), Gaps = 43/317 (13%) Query: 44 EIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEH 103 E+ SG+ + + + D+ W+ ++V A D T +++D + + +H Sbjct: 41 EVQDSGQTIPKAQQMHTGPVLDVCWS-DDGSKVFTASCDKTAKMWDLSSNQA--IQIAQH 97 Query: 104 EREVFSCNW-NLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIIL 162 + V + +W N ++ SWD ++K W +M L A ++ Sbjct: 98 DAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERC-------YCADVI 150 Query: 163 KKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLE 222 + ++ VYQ + P + + S H + Sbjct: 151 YPMAVVATAERGLIVYQLENQPSEFRRIES--------------------PLKHQHRCVA 190 Query: 223 ALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAH 282 NK + A G ++ + I N K + H S+ N Sbjct: 191 IFKDKQNKPTGF--ALGSIEGRVAI-----HYINPPNPAKDNFTFKCHRSNGTNTSAPQD 243 Query: 283 GLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHS 342 A+ + + P H L + D W + K + + + FN + Sbjct: 244 IYAVNGIAFHPVHGT-LATVGSDGRFSFWDKDARTKLKTSEQLD--QPISACCFNHNGNI 300 Query: 343 -EFVFGADWSLWGKPGY 358 + DWS G Y Sbjct: 301 FAYASSYDWS-KGHEFY 316 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 27/150 (18%), Positives = 44/150 (29%), Gaps = 38/150 (25%) Query: 225 TCDFNK--YRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAH 282 F+ + G N +R W+++ + I + H Sbjct: 15 CLSFSPPTLPGNFLIAGSWANDVRCWEVQ------------------DSGQTIPKAQQMH 56 Query: 283 GLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHS 342 + V WS S + +AS D T ++W SN + QH Sbjct: 57 TGPVLDVCWSDDGSKVF-TASCDKTAKMWDLSSNQAIQ-----------------IAQHD 98 Query: 343 EFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 V W V + +WD L W+ Sbjct: 99 APVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 Score = 44.9 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 23/149 (15%), Positives = 48/149 (32%), Gaps = 26/149 (17%) Query: 170 ISKNRNCVYQAQFSPHD--QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCD 227 S + + FSP N +++ S + ++++ +H+G + Sbjct: 6 TSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTG--PVLDV 63 Query: 228 FNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIR 287 V T D ++WD+ SS H ++ Sbjct: 64 CWSDDGSKVFTASCDKTAKMWDL---------------------SSNQAIQIAQHDAPVK 102 Query: 288 KVTW-SPHHSNILMSASYDMTCRIWRDLS 315 + W + + +M+ S+D T + W S Sbjct: 103 TIHWIKAPNYSCVMTGSWDKTLKFWDTRS 131 >4XFV-A nrPDB Length = 792 Score = 68.8 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 56/347 (16%), Positives = 107/347 (30%), Gaps = 55/347 (15%) Query: 74 NQVLVAQGDGTLRLFD--TTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKI 131 +++ T+ L+D + A K HE EV + + + +S+S D +KI Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF-VPDSDFMVSASEDHHVKI 89 Query: 132 W---SPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQ- 187 W Q + T+ I + + I + T +N +F + Sbjct: 90 WKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQND-EFGLAHEF 148 Query: 188 ---------------------NLVLSCSGN-----SYASLFDIRLPSGKNQNNFLVHSGL 221 L+ N + L D + + H Sbjct: 149 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 208 Query: 222 EALTCDFNKYR---PYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEI 278 + F Y++ +G D IR+W IR+ + + + L N +I Sbjct: 209 -VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQI 267 Query: 279 PN-------------AHGLAIRKVTWSPHHSNI-LMSASYDMTCRIWRDLSNDGAKETYK 324 + H I + W H S + L++A+ D + +W G Sbjct: 268 DDELRVGINFEALIMGHDDWISSLQW--HESRLQLLAATADTSLMVWEPDETSGIWVCSL 325 Query: 325 TNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 ++KG+ T S + W + + + G+ +W Sbjct: 326 RLGEMSSKGASTA-TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW 371 Score = 56.1 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 53/327 (16%), Positives = 106/327 (32%), Gaps = 48/327 (14%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLF-----DTTFKEFPIAIFKEHER---EVFS-CNWN 113 + D+AW+ S +L D T RLF D + ++ IA + E R + Sbjct: 392 VTDIAWSPS-GEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE 450 Query: 114 LVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 173 V F+S + ++ + + + M ++ + + ++ + + + Sbjct: 451 TVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGE 510 Query: 174 RNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFL-------VHSGLEALTC 226 + + + SL + + Q + L G E Sbjct: 511 DDANEDDEEEEGGNKETPDITD--PLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCL 568 Query: 227 DFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAI 286 D + ++A+ N ++ IR+ + IK +P H L I Sbjct: 569 DISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF--------------HSLTI 613 Query: 287 RKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF-NFTQHSEFV 345 ++ +S L+S D +W + N D T F N H+ + Sbjct: 614 TRLKFSK-DGKFLLSVCRDRKWALW------------ERNMEDNTFELRFKNEKPHTRII 660 Query: 346 FGADWSLWGKPGYVASTAWDGNLFVWN 372 + ADW+ + + D + VW Sbjct: 661 WDADWAPLEFGNVFVTASRDKTVKVWR 687 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 44/276 (15%), Positives = 87/276 (31%), Gaps = 51/276 (18%) Query: 66 LAWNESHENQVLVAQGDGTLRLFDTTF--------KEFPIAIFKEHEREVFSCNW---NL 114 L+ ++ E + L+A G + +F +F K +A + HE V S + Sbjct: 160 LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQET 219 Query: 115 VNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGIS--- 171 S S D I++W + ++T + + + + GI+ Sbjct: 220 PGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEA 279 Query: 172 ---KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSG-------------KNQNNF 215 + + + Q+ L+ + + ++ +++ SG K + Sbjct: 280 LIMGHDDWISSLQWHESRLQLLAATA-DTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 338 Query: 216 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 SG F R T G + R+W N C Sbjct: 339 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW------------------ATKDNIICD 380 Query: 276 NEI-PNAHGLAIRKVTWSPHHSNILMSASYDMTCRI 310 + + + + WSP L++ S D T R+ Sbjct: 381 QRLGISGATKDVTDIAWSPSGE-YLLATSLDQTTRL 415 Score = 45.3 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 31/231 (13%), Positives = 70/231 (30%), Gaps = 34/231 (14%) Query: 145 PRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI 204 + + + ++P N + + + V +F P D + ++S S + + ++ Sbjct: 39 GKTIALWDPIEPNNKGVYAT-----LKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKF 92 Query: 205 RLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRT 264 S + H + +++ G D I IW + N + T Sbjct: 93 TDYSHLQCIQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQNIQNDEFGLAHEFT 149 Query: 265 VPGQLHNSSCINEIPNAHGL---AIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKE 321 + C++ AI + ++ ++S S CR+ +L Sbjct: 150 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEG----- 204 Query: 322 TYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 D K F + + + S + D + +W Sbjct: 205 -----HEDWVKSLAFRHQE----------TPGD--YLLCSGSQDRYIRLWR 238 Score = 33.3 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 60/160 (37%), Gaps = 14/160 (8%) Query: 3 RYHMQGFSGYGVQYSPFFDNRL-AVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLT-Q 60 + + GF + SP D +L A A SN N + ++ I + +E+ L Sbjct: 557 KLYGHGFEITCLDISP--DQKLIASACRSN-----NVQNAVIRIFSTENWLEIKPALPFH 609 Query: 61 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFP-IAIFKE---HEREVFSCNWNL-V 115 +L D L++ ++ FK H R ++ +W Sbjct: 610 SLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE 669 Query: 116 NRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVD 155 F+++S D ++K+W ++ + + ++ TK V Sbjct: 670 FGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVT 709 >4BTS-AR nrPDB Length = 343 Score = 66.9 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 31/214 (14%), Positives = 59/214 (27%), Gaps = 38/214 (17%) Query: 72 HENQVLVAQGDGTLRLFDTTFKEF------PIAIFKEHEREVFSCNWNLVNRQNFLSSSW 125 ++ D T+ ++ +E P H V + N SSSW Sbjct: 38 DSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAI-SSSW 96 Query: 126 DGSIKIWSPLRKQSLMTLTPRPLEITKMVDPL-----------------NAIILKKKSFT 168 D ++++W + E+ + N + K S Sbjct: 97 DKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSA 156 Query: 169 GISKNRNCVYQAQFSPHDQNL---------VLSCSGNSYASLFDIRLPSGKNQNNFLVHS 219 + + V ++SP ++ S + +++ Sbjct: 157 EKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNF----QIRYTFKAH 212 Query: 220 GLEALTCDFNKYRPYVVATGGVDNAIRIWDIRML 253 + +ATGG D + IWDI L Sbjct: 213 ESNVNHLSISP-NGKYIATGGKDKKLLIWDILNL 245 Score = 60.3 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 70/218 (32%), Gaps = 34/218 (15%) Query: 161 ILKKKSFTGISKNRNCVYQ--AQFSPHDQNLVLSCSGNSYASLFDI--RLPSGKNQNNFL 216 ++K+ G S + +Q D +++S S + ++ + +G Sbjct: 11 VVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHK 70 Query: 217 VHSGLEALTCDFN-KYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 +G D + D +R+WD+R + Sbjct: 71 ALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFV--------------- 115 Query: 276 NEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSI 335 H + V +SP + IL SA + ++W L K N +D S Sbjct: 116 -----GHQSEVYSVAFSPDNRQIL-SAGAEREIKLWNILGECKFSSAEKENHSDW--VSC 167 Query: 336 FNFTQHSEFVFGAD-WSLWGKPGYVASTAWDGNLFVWN 372 ++ + ++ Y AS WDG L VWN Sbjct: 168 VRYSPIMKSANKVQPFAP-----YFASVGWDGRLKVWN 200 Score = 56.1 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 25/141 (17%), Positives = 47/141 (33%), Gaps = 32/141 (22%) Query: 235 VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 V+ +G D + IW + +N I ++ H + + S Sbjct: 41 VLISGSRDKTVMIWKLYEEEQNGYFGIP-------------HKALTGHNHFVSDLALSQE 87 Query: 295 HSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG 354 + +S+S+D T R+W + K F H V+ +S Sbjct: 88 NC-FAISSSWDKTLRLWDLRTGTTYKR----------------FVGHQSEVYSVAFSPDN 130 Query: 355 KPGYVASTAWDGNLFVWNGLG 375 + + S + + +WN LG Sbjct: 131 RQ--ILSAGAEREIKLWNILG 149 >4N14-A nrPDB Length = 314 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 46/320 (14%), Positives = 102/320 (31%), Gaps = 60/320 (18%) Query: 72 HENQVLVAQGDGTLRLFDTTFKE-FPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 VL D ++ L+ + + + ++ + S W + + ++ Sbjct: 30 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW-IKEGNYLAVGTSSAEVQ 88 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPL--------------NAIILKKKSFTGISKNRNC 176 +W +++ L +T + + + + + + +S + Sbjct: 89 LWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQE 148 Query: 177 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQN-NFLVHSGLEALTCDFNKYRPYV 235 V +++P ++L S ++ +++ G + ++ V Sbjct: 149 VCGLRWAPDGRHL-ASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV 207 Query: 236 VATGG--VDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSP 293 +ATGG D IRIW++ + +C+ +AH + + WSP Sbjct: 208 LATGGGTSDRHIRIWNV-------------------CSGACL-SAVDAHS-QVCSILWSP 246 Query: 294 HHSNILMSASY-DMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSL 352 H+ ++ + IW+ + E H+ V S Sbjct: 247 HYKELISGHGFAQNQLVIWKYPTMAKVAEL----------------KGHTSRVLSLTMSP 290 Query: 353 WGKPGYVASTAWDGNLFVWN 372 G VAS A D L +W Sbjct: 291 DGAT--VASAAADETLRLWR 308 Score = 60.3 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 40/251 (15%), Positives = 82/251 (32%), Gaps = 55/251 (21%) Query: 65 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSS 124 L+WN + G + D E +A H +EV W + ++ S Sbjct: 110 SLSWN---SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRW-APDGRHLASGG 165 Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 D + +W + PL ++++ V + P Sbjct: 166 NDNLVNVWPSAPGEGGWV-------------PLQTF----------TQHQGAVKAVAWCP 202 Query: 185 HDQNLVLSCSG--NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVAT-GGV 241 N++ + G + + ++++ SG + HS + + ++ + +++ G Sbjct: 203 WQSNVLATGGGTSDRHIRIWNV--CSGACLSAVDAHS--QVCSILWSPHYKELISGHGFA 258 Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMS 301 N + IW + K H + +T SP + + S Sbjct: 259 QNQLVIWKYPTMAKVAE--------------------LKGHTSRVLSLTMSPDGATV-AS 297 Query: 302 ASYDMTCRIWR 312 A+ D T R+WR Sbjct: 298 AAADETLRLWR 308 >5XYI-g nrPDB Length = 335 Score = 66.5 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 38/267 (14%), Positives = 89/267 (33%), Gaps = 58/267 (21%) Query: 56 SFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEF----PIAIFKEHEREVFSCN 111 +F+ + + ++ N ++ A D + ++ + P H V + Sbjct: 28 TFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVS 87 Query: 112 WNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGIS 171 + + L+SSWD ++++W + + Sbjct: 88 LSRD-ASHLLTSSWDSTLRLWDLST---------------------------RTTKKLFL 119 Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTC--DFN 229 ++ V FSP ++ ++S ++ +++I G+N+ S + ++ C + Sbjct: 120 GHKKDVLGVTFSPCNR-RIISVGRDNQVKIWNI---LGENKAELQCSSWVTSVACAPMAD 175 Query: 230 KYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKV 289 + P V+A G D + IW I K + H+ C V Sbjct: 176 ETSPLVIAVGCWDGKVYIWSIE-------KEAKLIKEFKAHDGRC------------TSV 216 Query: 290 TWSPHHSNILMSASYDMTCRIWRDLSN 316 ++P +++ D +W + Sbjct: 217 DFTP-DGKWVITGGSDRKVVMWLTENG 242 Score = 56.5 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 66/202 (32%), Gaps = 38/202 (18%) Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFN-K 230 + + + LV S S + A ++ + + F G D + Sbjct: 31 GHNAAIESIEIDNEHNYLV-SASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLS 89 Query: 231 YRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVT 290 + T D+ +R+WD+ ++ ++ H + VT Sbjct: 90 RDASHLLTSSWDSTLRLWDL--------------------STRTTKKLFLGHKKDVLGVT 129 Query: 291 WSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADW 350 +SP + I+ S D +IW L + A+ + T V A Sbjct: 130 FSPCNRRII-SVGRDNQVKIWNILGENKAELQCSSWVTS---------------VACAPM 173 Query: 351 SLWGKPGYVASTAWDGNLFVWN 372 + P +A WDG +++W+ Sbjct: 174 ADETSPLVIAVGCWDGKVYIWS 195 Score = 39.5 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 16/155 (10%), Positives = 42/155 (27%), Gaps = 26/155 (16%) Query: 76 VLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPL 135 + V DG + ++ + I FK H+ S ++ + ++ D + +W Sbjct: 182 IAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKW-VITGGSDRKVVMWLTE 240 Query: 136 RKQSLMTLTPRPLEITKMVDPLNAIILK------------------------KKSFTGIS 171 ++ T P A I K + Sbjct: 241 NGAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNA 300 Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRL 206 ++ +++ S + ++++ Sbjct: 301 GRTPDCTCLAWAADG-SVLYSGYNDGSIRAWEVKS 334 >5WLC-LJ nrPDB Length = 513 Score = 66.5 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 101/308 (32%), Gaps = 49/308 (15%) Query: 3 RYHMQGFSGY-GVQYSPFF--DNRLAVAAGSNFGLVG-----NGKLFILEIDRSGRIVEV 54 R ++ FS + V YS F D +L + AG GLV N + +L I+ S V Sbjct: 71 RQVIKTFSRFKDVVYSASFRSDGKL-LCAGDATGLVSVYDSYNPRTILLSINASTHPTHV 129 Query: 55 NSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNL 114 F TQD + A D RL+D + P V + ++ Sbjct: 130 TKFHTQD-----------NKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIP 178 Query: 115 VNRQNFLSSSWDGSIKIWSPLRK---QSLMTLTPRPLEITKMVDPLNAIILKKKSFT--G 169 + S+DG I+++ +P+E V P + +F Sbjct: 179 AAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGGNNFKVWD 238 Query: 170 ISKNRNCVYQAQF--------------SPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 215 ++ N+ + F SP L+ S S + + +FD P Q F Sbjct: 239 LTSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIAS-SLDGHVKVFD---PLDNFQVKF 294 Query: 216 LVHSGLEALTCDFNK---YRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNS 272 L+C + + G + I R K + ++ K P + + Sbjct: 295 GWKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAI---RTKKKEKRSSDKENAPASFNKN 351 Query: 273 SCINEIPN 280 + N Sbjct: 352 AKSNNFQR 359 >5L9T-R nrPDB Length = 493 Score = 65.7 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 47/276 (17%), Positives = 86/276 (31%), Gaps = 50/276 (18%) Query: 61 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNF 120 D + + W+E N V V G ++++D + +++ + H V + WN Sbjct: 230 DSVTSVGWSE-RGNLVAVGTHKGFVQIWDAAAGKK-LSMLEGHTARVGALAWNAEQ---L 284 Query: 121 LSSSWDGSIKIWSPLRKQS---------------LMTLTPRPLEITKMVDPLNAIILKKK 165 S S D I L T L + D + Sbjct: 285 SSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSS 344 Query: 166 SF--TGISKNRNCVYQAQFSPHDQNLVLSCSG--NSYASLFDIRLPSGKNQNNFLVHSGL 221 +++ V +SPH L+ S G + ++ + Q + +G Sbjct: 345 LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWN----TLTGQPLQCIDTGS 400 Query: 222 EALTCDFNKYRPYVVAT-GGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPN 280 + ++K+ +V+T G N I +W L + T Sbjct: 401 QVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLT-------------------- 440 Query: 281 AHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSN 316 H + + SP I ++ + D T R W S Sbjct: 441 GHSYRVLYLAMSPDGEAI-VTGAGDETLRFWNVFSK 475 Score = 64.5 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 46/318 (14%), Positives = 85/318 (26%), Gaps = 85/318 (26%) Query: 85 LRLFDTTFKEFPIAI-FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTL 143 + L+ + V S W+ + G ++IW + L L Sbjct: 209 VYLWSACTSQVTRLCDLSVEGDSVTSVGWSE-RGNLVAVGTHKGFVQIWDAAAGKKLSML 267 Query: 144 TPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFD 203 + + ++ + S S + D Sbjct: 268 EGHTARVGAL---------------------------AWNAEQ---LSSGSRDRMILQRD 297 Query: 204 IRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKR 263 IR P +++ H + + ++A+GG DN + +W+ Sbjct: 298 IRTPPLQSERRLQGHR--QEVCGLKWSTDHQLLASGGNDNKLLVWN-------------- 341 Query: 264 TVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSAS--YDMTCRIWRDLSNDGAK- 320 H+S + H A++ + WSPH +L S D R W L+ + Sbjct: 342 ------HSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQC 395 Query: 321 -----ETYKTNSTDATKGSIFNFT---------------------QHSEFVFGADWSLWG 354 + + + HS V S G Sbjct: 396 IDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDG 455 Query: 355 KPGYVASTAWDGNLFVWN 372 + + + A D L WN Sbjct: 456 EA--IVTGAGDETLRFWN 471 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 28/171 (16%), Positives = 60/171 (35%), Gaps = 21/171 (12%) Query: 65 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSS- 123 L W+ H+ + D L +++ + P+ + EH V + W+ S Sbjct: 318 GLKWSTDHQ-LLASGGNDNKLLVWNHSSL-SPVQQYTEHLAAVKAIAWSPHQHGLLASGG 375 Query: 124 -SWDGSIKIWSPLRKQSLMTLTPRP-------------LEITKMVDPLNAIILKKKSFTG 169 + D I+ W+ L Q L + L T ++ K S T Sbjct: 376 GTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQ 435 Query: 170 ISKNRNCVYQA---QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLV 217 ++K Y+ SP + +++ +G+ +++ + + + V Sbjct: 436 VAKLTGHSYRVLYLAMSPDGEA-IVTGAGDETLRFWNVFSKTRSTKESVSV 485 >6CHG-A nrPDB Length = 312 Score = 64.9 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 37/242 (15%), Positives = 81/242 (33%), Gaps = 44/242 (18%) Query: 135 LRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCS 194 + ++ + I + D L I K + ++ C+ +SP D + S S Sbjct: 15 ISTSCQISPDGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSP-DSKCIASGS 73 Query: 195 GNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 + + I + L+ ++ +N + ++ + +D +I+ W + Sbjct: 74 EDFTVEITHIIYGRIRR----LMGHTAPVISICYNN-KGNILCSSSMDESIKEWHV---- 124 Query: 255 KNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDL 314 + + + + +AH A+ + S+IL S SYD RI+ Sbjct: 125 ---------------LSGTALKTM-SAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTE 168 Query: 315 SNDGAKETYKTN---STDA-TKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFV 370 S K + D S F+++ +F+ + D + + Sbjct: 169 SGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLL--------------VKSLDNVVKL 214 Query: 371 WN 372 W Sbjct: 215 WE 216 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 39/104 (37%), Gaps = 3/104 (2%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 122 + + +N + N + + D +++ + + H V S + + S Sbjct: 98 VISICYN-NKGNILCSSSMDESIKEWHVLSGTA-LKTMSAHSDAVVSIDIPKFDSSILSS 155 Query: 123 SSWDGSIKIWSPLRKQSLMTLT-PRPLEITKMVDPLNAIILKKK 165 S+DG I+I+ L TLT + V P++ + + Sbjct: 156 GSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRN 199 Score = 38.4 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 23/155 (14%), Positives = 50/155 (32%), Gaps = 26/155 (16%) Query: 61 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEF-------PIAIFKEHEREVFSCNWN 113 D + + + + + DG +R+FDT I ++ + + ++ Sbjct: 138 DAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFS 197 Query: 114 LVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 173 N + L S D +K+W R + T L T Sbjct: 198 R-NGKFLLVKSLDNVVKLWEYTRGTVVRTF------------------LWPHQETKAKLK 238 Query: 174 RNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPS 208 NC + + LV+S + + ++++ + Sbjct: 239 YNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKN 273 Score = 33.0 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 38/104 (36%), Gaps = 20/104 (19%) Query: 271 NSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDA 330 +SS + ++ H I + WSP S + S S D T I T Sbjct: 42 SSSKMMKLTTTHKECINCLCWSP-DSKCIASGSEDFTVEI-----------------THI 83 Query: 331 TKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGL 374 G I H+ V ++ K + S++ D ++ W+ L Sbjct: 84 IYGRIRRLMGHTAPVISICYN--NKGNILCSSSMDESIKEWHVL 125 Score = 32.2 bits (71), Expect = 0.34, Method: Composition-based stats. Identities = 9/53 (16%), Positives = 23/53 (43%) Query: 53 EVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHER 105 E + L +C +L + + + V+ G++ +++ K I ++H Sbjct: 232 ETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRN 284 >4E5Z-B nrPDB Length = 436 Score = 64.9 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 30/208 (14%), Positives = 69/208 (33%), Gaps = 18/208 (8%) Query: 64 FDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFK-EHEREVFSCNWNLVNRQNFLS 122 LAW+ +H + V V G + L++ K+ P I + +N +N F + Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 182 Query: 123 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISK---------- 172 SS +G+ ++ + + + I ++A + + Sbjct: 183 SSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKE 242 Query: 173 ------NRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTC 226 ++ V +P + + S + ++D+R GK + + Sbjct: 243 LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAA 302 Query: 227 DFNKYRPYVVATGGVDNAIRIWDIRMLN 254 F+ + T + IR++ + Sbjct: 303 CFSP-DGARLLTTDQKSEIRVYSASQWD 329 Score = 56.8 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 47/316 (14%), Positives = 108/316 (34%), Gaps = 61/316 (19%) Query: 8 GFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLA 67 G S G++++P N+ ++ + G +L D G I+ V + ++ + Sbjct: 164 GGSITGLKFNPLNTNQFYASS-----MEGTTRL----QDFKGNILRVFASSDTINIWFCS 214 Query: 68 WNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDG 127 + S ++++V GD + + + H+++V N ++S D Sbjct: 215 LDVSASSRMVVT-GDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQ 273 Query: 128 SIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQ 187 ++KIW + + K SF +R+ V A FSP Sbjct: 274 TVKIWDLRQ------------------------VRGKASFLYSLPHRHPVNAACFSPDGA 309 Query: 188 NLVLSCSGNSYASL-------FDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG 240 L+ + + + + +D P G + L + ++ +V Sbjct: 310 RLLTT---DQKSEIRVYSASQWDC--PLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRY 364 Query: 241 VD---NAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSN 297 D + +++R ++ + + K SS I+ + ++P Sbjct: 365 PDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLN----------EFNPMGDT 414 Query: 298 ILMSASYDMTCRIWRD 313 ++++ IW + Sbjct: 415 --LASAMGYHILIWSE 428 Score = 53.8 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 40/283 (14%), Positives = 72/283 (25%), Gaps = 56/283 (19%) Query: 130 KIWSPLRKQSL------MTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA--- 180 +W L + + T ++ + P L++ + R A Sbjct: 60 CLWVGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFD 119 Query: 181 ------QFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH-SGLEALTCDFNKYRP 233 + P + V S L++ +G FN Sbjct: 120 RRATSLAWHPTHPSTVAVGSKGGDIMLWN--FGIKDKPTFIKGIGAGGSITGLKFNPLNT 177 Query: 234 YVVATGGVDNAIRIWDIR--MLNKNESATIKRTVPGQLHNSSCINEIPNA---------- 281 ++ R+ D + +L S+ L S+ + Sbjct: 178 NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN 237 Query: 282 -----------HGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDA 330 H + V +P L +AS D T +IW G Sbjct: 238 MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRG------------ 285 Query: 331 TKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 K S H V A +S G + +T + V++ Sbjct: 286 -KASFLYSLPHRHPVNAACFSPDGAR--LLTTDQKSEIRVYSA 325 >1NR0-A nrPDB Length = 611 Score = 64.5 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 41/280 (14%), Positives = 84/280 (30%), Gaps = 53/280 (18%) Query: 49 GRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIA-IFKEHEREV 107 G + + + +A G +R++DTT + V Sbjct: 47 GSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPV 106 Query: 108 FSCNWNLVNRQNFLSSSWD----GSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILK 163 +W+ + + G + ++ +T R + Sbjct: 107 KDISWDS-ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAM--------------- 150 Query: 164 KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA 223 F P ++S S ++ ++F+ P K ++ F Sbjct: 151 --------------NSVDFKPSRPFRIISGSDDNTVAIFE--GPPFKFKSTF-GEHTKFV 193 Query: 224 LTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHG 283 + +N + A+ G D I +++ +T + + + AH Sbjct: 194 HSVRYNP-DGSLFASTGGDGTIVLYN--------GVDGTKTGVFEDDSLKNV-----AHS 239 Query: 284 LAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETY 323 ++ +TWSP + I SAS D T +IW + K Sbjct: 240 GSVFGLTWSPDGTKI-ASASADKTIKIWNVATLKVEKTIP 278 Score = 58.0 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 49/282 (17%), Positives = 90/282 (31%), Gaps = 62/282 (21%) Query: 91 TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEI 150 + + I H+ V + + S G+++IW + I Sbjct: 48 SLTDTEIYTEHSHQTTVAKTS---PSGYYCASGDVHGNVRIWDTTQT----------THI 94 Query: 151 TKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK 210 K P+ + +K S+ SK V + + L + + N +G+ Sbjct: 95 LKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNL--------TGQ 146 Query: 211 NQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLH 270 + + DF RP+ + +G DN + I++ + Sbjct: 147 ARA---------MNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF----------- 186 Query: 271 NSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDA 330 H + V ++P S + S D T ++ + DG K + + Sbjct: 187 ---------GEHTKFVHSVRYNPDGS-LFASTGGDGTIVLYNGV--DGTKTGVFEDDS-- 232 Query: 331 TKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 HS VFG WS G +AS + D + +WN Sbjct: 233 -----LKNVAHSGSVFGLTWSPDGTK--IASASADKTIKIWN 267 Score = 56.5 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 64/392 (16%), Positives = 120/392 (30%), Gaps = 85/392 (21%) Query: 55 NSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFD----TTFKEFPIAIFK--EHEREVF 108 ++F + GDGT+ L++ T F K H VF Sbjct: 184 STFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVF 243 Query: 109 SCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT 168 W+ S+S D +IKIW+ + T+ T++ D II K++ Sbjct: 244 GLTWSPD-GTKIASASADKTIKIWNVATLKVEKTIPVG----TRIEDQQLGIIWTKQALV 298 Query: 169 GISKNR---------NCVYQAQFSPHDQNLVLSCSGNSY----------ASLFDIRLPSG 209 IS N + Q ++ + LS S + + +DI +G Sbjct: 299 SISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS--TG 356 Query: 210 KNQNNFLVHSGL-----------EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNES 258 + F + T ++ + V A G ++ + + ++ Sbjct: 357 ISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKA--VANKLSSQP 414 Query: 259 ATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWS--------PHHSNILMSASYDMTCRI 310 + + G + ++C I + +V S + + D + Sbjct: 415 LGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHV 474 Query: 311 WRD---------------------LSNDGAKETYKTNSTDATKGSIFN---------FTQ 340 ++ SN+GA S S+ N +T Sbjct: 475 YKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTF 534 Query: 341 HSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H+ V WS +A+ + D ++ VWN Sbjct: 535 HTAKVACVSWSPDNVR--LATGSLDNSVIVWN 564 Score = 37.2 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 38/247 (15%), Positives = 76/247 (30%), Gaps = 41/247 (16%) Query: 11 GYGVQYSPFFDNRL-------AVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCL 63 G GV S N+L AV+A + + K + I G++ EV Sbjct: 397 GSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKH--IAIYSHGKLTEV----PISYN 450 Query: 64 FDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSS 123 + + V V D + ++ + H E+ S ++ + Sbjct: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATD 510 Query: 124 SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFS 183 I P + L S+T + CV +S Sbjct: 511 QSRKVI----PYSVANNFEL------------------AHTNSWTFHTAKVACV---SWS 545 Query: 184 PHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDN 243 P D + + S ++ ++++ PS H+ + + + + G D+ Sbjct: 546 P-DNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIW--LNETTIVSAGQDS 602 Query: 244 AIRIWDI 250 I+ W++ Sbjct: 603 NIKFWNV 609 Score = 36.8 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 27/185 (14%), Positives = 60/185 (32%), Gaps = 28/185 (15%) Query: 134 PLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQA-----QFSPHDQN 188 P+ S + + + + + K S +S+ + V+ A FS + Sbjct: 446 PISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAF 505 Query: 189 LVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 LV + + + + N + ++ +ATG +DN++ +W Sbjct: 506 LVAT-DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP-DNVRLATGSLDNSVIVW 563 Query: 249 DIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHG-LAIRKVTWSPHHSNILMSASYDMT 307 ++ + + I AH ++ V W + ++SA D Sbjct: 564 NMNKPSDHPII------------------IKGAHAMSSVNSVIW--LNETTIVSAGQDSN 603 Query: 308 CRIWR 312 + W Sbjct: 604 IKFWN 608 >3ODT-A nrPDB Length = 313 Score = 63.0 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 40/285 (14%), Positives = 77/285 (27%), Gaps = 85/285 (29%) Query: 91 TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEI 150 T E P+ H+ V S ++ +S SWD + K+W + L + Sbjct: 91 TSGEDPLYTLIGHQGNVCSLSF---QDGVVISGSWDKTAKVW--KEGSLVYNLQAHNASV 145 Query: 151 TKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLF--DIRLPS 208 A+ +N L+ S + L+ D + + Sbjct: 146 W---------------------------DAKVVSFSENKFLTASADKTIKLWQNDKVIKT 178 Query: 209 GKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQ 268 +N +V F + D I++ D+ Sbjct: 179 FSGIHNDVVRHLAVVDDGHF--------ISCSNDGLIKLVDM------------------ 212 Query: 269 LHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNST 328 H + H + + P+ ++S D T RIW N K+ + Sbjct: 213 -HTGDVLRTYE-GHESFVYCIKLLPNGD--IVSCGEDRTVRIW-SKENGSLKQVITLPAI 267 Query: 329 DATKGSIFNFTQHSEFVFGADWSLWG-KPGYVASTAWDGNLFVWN 372 WS+ G + + D + +++ Sbjct: 268 SI-------------------WSVDCMSNGDIIVGSSDNLVRIFS 293 Score = 56.8 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 28/200 (14%), Positives = 66/200 (33%), Gaps = 27/200 (13%) Query: 65 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSS 124 ++ + V+ D T +++ + + + H V+ + FL++S Sbjct: 106 NVCSLSFQDGVVISGSWDKTAKVWK---EGSLVYNLQAHNASVWDAKVVSFSENKFLTAS 162 Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGI-------------- 170 D +IK+W + + T + ++ + + ++ S G+ Sbjct: 163 ADKTIKLWQ--NDKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRT 220 Query: 171 -SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFN 229 + + VY + P+ ++SC + ++ S K S Sbjct: 221 YEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDC---- 274 Query: 230 KYRPYVVATGGVDNAIRIWD 249 + G DN +RI+ Sbjct: 275 -MSNGDIIVGSSDNLVRIFS 293 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 41/293 (13%), Positives = 77/293 (26%), Gaps = 70/293 (23%) Query: 98 AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWS---------PLRKQSLMTLTPRPL 148 A K H+++V V+ S S DG++++WS Q + Sbjct: 12 ATLKGHDQDVRDVV--AVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDS 69 Query: 149 EITKMVDPLNAIILKKKSFTGIS---------KNRNCVYQAQFSPHDQNLVLSCSGNSYA 199 E ++ ++ S ++ V F +V+S S + A Sbjct: 70 EKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF---QDGVVISGSWDKTA 126 Query: 200 SLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESA 259 ++ G N + T D I++W Sbjct: 127 KVW----KEGSLVYNLQ-AHNASVWDAKVVSFSENKFLTASADKTIKLW----------- 170 Query: 260 TIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGA 319 N I H +R + +S S D ++ + D Sbjct: 171 ----------QNDKVIKTFSGIHNDVVR--HLAVVDDGHFISCSNDGLIKLVDMHTGDVL 218 Query: 320 KETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + + H FV+ G + S D + +W+ Sbjct: 219 RT----------------YEGHESFVYCIKLLPNGD---IVSCGEDRTVRIWS 252 >4AEZ-A nrPDB Length = 401 Score = 63.0 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 49/291 (16%), Positives = 85/291 (29%), Gaps = 55/291 (18%) Query: 35 VGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKE 94 +GNG + I +++ ++ + + L+WN + G + D Sbjct: 153 LGNGLVDIYDVESQTKLRTMAGHQARVGC--LSWNRHV---LSSGSRSGAIHHHDVRIAN 207 Query: 95 FPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMV 154 I + H EV W S D ++IW T T Sbjct: 208 HQIGTLQGHSSEVCGLAWRSD-GLQLASGGNDNVVQIWDARSSIPKFTKTNHN------- 259 Query: 155 DPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNN 214 V + P NL+ + G + +G N Sbjct: 260 --------------------AAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNT 299 Query: 215 FLVHSGLEALTCDFNKYRPYVVATGGV-DNAIRIWDIRMLNKNESATIKRTVPGQLHNSS 273 V +G + + ++ + +++T G DN + IW + Sbjct: 300 --VDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIW-----------------SYSSSGLT 340 Query: 274 CINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYK 324 +IP AH + SP IL +A+ D + WR D K Sbjct: 341 KQVDIP-AHDTRVLYSALSP-DGRILSTAASDENLKFWRVYDGDHVKRPIP 389 Score = 58.0 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 83/299 (27%), Gaps = 73/299 (24%) Query: 76 VLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPL 135 V+ + + +++ + V S W+ +G + I+ Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHD-GSFLSVGLGNGLVDIYDVE 164 Query: 136 RKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSG 195 + L T+ + + + ++ S S Sbjct: 165 SQTKLRTMAGHQARVGCLSWNRH------------------------------VLSSGSR 194 Query: 196 NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNK 255 + D+R+ + HS E + +A+GG DN ++IWD R Sbjct: 195 SGAIHHHDVRIAN-HQIGTLQGHSS-EVCGLAWRS-DGLQLASGGNDNVVQIWDARSSIP 251 Query: 256 NESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSAS--YDMTCRIWRD 313 + T H A++ V W P SN+L + D W Sbjct: 252 KFTKTN--------------------HNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNA 291 Query: 314 LSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + + N+ DA V WS K D NL +W+ Sbjct: 292 ATG------ARVNTVDA-----------GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWS 333 Score = 38.4 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 29/182 (15%), Positives = 49/182 (26%), Gaps = 30/182 (16%) Query: 195 GNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLN 254 + Y +L D + +V LE +N V A D + + ++ + Sbjct: 92 DDYYLNLLDWSNLN-------VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSH 144 Query: 255 KNESAT---IKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 + V S H + ++W+ H +L S S Sbjct: 145 DGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRH---VLSSGSRSGAIHHH 201 Query: 312 RDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 I HS V G W G +AS D + +W Sbjct: 202 D---------------VRIANHQIGTLQGHSSEVCGLAWRSDG--LQLASGGNDNVVQIW 244 Query: 372 NG 373 + Sbjct: 245 DA 246 >3EI3-B nrPDB Length = 383 Score = 61.9 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 35/204 (17%), Positives = 65/204 (31%), Gaps = 17/204 (8%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFK-EHEREVFSCNWNLVNRQNFL 121 + L W+ +H V V G + L+D + I + +N N Sbjct: 76 VTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLF 135 Query: 122 SSSWDGSIKI----------------WSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKK 165 SS G+ + W ++++ + L L + L Sbjct: 136 VSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGH 195 Query: 166 SFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALT 225 ++ V A+F+P L+ + S ++ L+D+R KN + Sbjct: 196 EIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNA 255 Query: 226 CDFNKYRPYVVATGGVDNAIRIWD 249 FN + T N IR++ Sbjct: 256 AYFNPTDSTKLLTTDQRNEIRVYS 279 Score = 55.7 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 27/222 (12%), Positives = 66/222 (29%), Gaps = 32/222 (14%) Query: 105 REVFSCNWNLVNRQNFLSSSWDGSIKIWS---PLRKQSLMTLTPRP----LEITKMVDPL 157 R V S W+ + S G I +W + + + P ++ + Sbjct: 74 RRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQ 133 Query: 158 NAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLV 217 + + + T + + + + + + +G+ L Sbjct: 134 LFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLD 193 Query: 218 HSGL--------EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQL 269 + + +FN +++AT VD +++WD+R + S + Sbjct: 194 GHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMP----- 248 Query: 270 HNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 H + ++P S L++ R++ Sbjct: 249 ------------HEKPVNAAYFNPTDSTKLLTTDQRNEIRVY 278 Score = 51.8 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 30/219 (13%), Positives = 61/219 (27%), Gaps = 27/219 (12%) Query: 146 RPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIR 205 + +P + K S V ++ P V S L+D Sbjct: 45 HAQLRQCLQEPFIRSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYD 104 Query: 206 LPSGKNQNNFLVHSGLEALTCD-FNKYRPYVVATGGVDNAIRIWD-----IRMLNKNESA 259 + + +A+T FN++ + + A + D I++ K +S Sbjct: 105 VQ--NKTSFIQGMGPGDAITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSW 162 Query: 260 TIKRTVPGQLHNSSCINE------------------IPNAHGLAIRKVTWSPHHSNILMS 301 + + H + ++P ++ + Sbjct: 163 DYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMAT 222 Query: 302 ASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQ 340 +S D T ++W DL N K +Y + F Sbjct: 223 SSVDATVKLW-DLRNIKDKNSYIAEMPHEKPVNAAYFNP 260 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 70/196 (35%), Gaps = 18/196 (9%) Query: 56 SFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKE--HEREVFSCNWN 113 L + + +N + + + D T++L+D + + E HE+ V + +N Sbjct: 200 EKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFN 259 Query: 114 LVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 173 + L++ I+++S + P + + P+ A + I Sbjct: 260 PTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKAT-WHP-MYDLIVAG 317 Query: 174 RNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRP 233 R P DQ L+ + ++D SG + + ++ + Sbjct: 318 R--------YPDDQLLL---NDKRTIDIYDA--NSGGLVHQLRDPNAAGIISLNKFSPTG 364 Query: 234 YVVATGGVDNAIRIWD 249 V+A+G + I IW+ Sbjct: 365 DVLASG-MGFNILIWN 379 >6F1U-h nrPDB Length = 612 Score = 61.9 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 49/331 (14%), Positives = 104/331 (31%), Gaps = 74/331 (22%) Query: 60 QDCLFDLAWNESHENQVLVAQG----------DGTLRLFDTTFKEFPIAIFKEHEREVFS 109 + L W+ S ++LVA DG +++ +K+ + V S Sbjct: 253 HRVVSCLDWS-SQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMS 311 Query: 110 CNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTG 169 + + + ++ G I +W R + PL P+ Sbjct: 312 ATFAKFHPNLVVGGTYSGQIVLWDN-RSNKRTPVQRTPLSAAAHTHPVY----------- 359 Query: 170 ISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTC--- 226 CV + + ++S S + + + + S + LVH +A+ Sbjct: 360 ------CVNVV--GTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSM 411 Query: 227 DFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAI 286 F G + ++ + + + I+E+ H I Sbjct: 412 SFPVGDVNNFVVGSEEGSVY------------------TACRHGSKAGISEMFEGHQGPI 453 Query: 287 RKVTWSP-----HHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQH 341 + S++ +++S+D T ++W +N +++F + Sbjct: 454 TGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNK----------------PLYSFEDN 497 Query: 342 SEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + +V+ WS P A G L +WN Sbjct: 498 AGYVYDVMWSP-THPALFACVDGMGRLDLWN 527 Score = 54.1 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 29/197 (14%), Positives = 64/197 (32%), Gaps = 40/197 (20%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIA----IFKEHEREVFSCNWNL---- 114 + +++ N +V +G++ T + A +F+ H+ + + + Sbjct: 408 VTSMSFPVGDVNNFVVGSEEGSVY---TACRHGSKAGISEMFEGHQGPITGIHCHAAVGA 464 Query: 115 -VNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 173 F++SS+D ++K+WS + L + N Sbjct: 465 VDFSHLFVTSSFDWTVKLWSTKNNKPLYSFED---------------------------N 497 Query: 174 RNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRP 233 VY +SP L G L+++ + + V + + Sbjct: 498 AGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRW-THSG 556 Query: 234 YVVATGGVDNAIRIWDI 250 +A G + I I+D+ Sbjct: 557 REIAVGDSEGQIVIYDV 573 >4BH6-A nrPDB Length = 308 Score = 60.3 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 48/300 (16%), Positives = 100/300 (33%), Gaps = 49/300 (16%) Query: 35 VGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKE 94 V GK L + +G +V + T++ L+W + + V Q +G + ++D ++ Sbjct: 39 VALGKSIFLTDNNTGDVVHLCD--TENEYTSLSW-IGAGSHLAVGQANGLVEIYDVMKRK 95 Query: 95 FPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSP-LRKQSLMTLTPRPLEI--- 150 I H V +WN S S D I + T+ E+ Sbjct: 96 C-IRTLSGHIDRVACLSWNN---HVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGL 151 Query: 151 ------TKMVDPLNAIILKKKSFTGIS------KNRNCVYQAQFSPHDQNLVLSCSG--N 196 K+ N ++ T S +++ V +SPH + ++ + G + Sbjct: 152 KWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTAD 211 Query: 197 SYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKN 256 ++++ + ++ S + + N V + G + +WD ++ Sbjct: 212 RRLKIWNV--NTSIKMSDIDSGSQICNMVWSKN-TNELVTSHGYSKYNLTLWDCNSMDPI 268 Query: 257 ESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSN 316 I H + +T S + + +S + D T R W+ Sbjct: 269 A--------------------ILKGHSFRVLHLTLSNDGTTV-VSGAGDETLRYWKLFDK 307 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 51/334 (15%), Positives = 102/334 (30%), Gaps = 90/334 (26%) Query: 68 WNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDG 127 W+ + VL ++ L D + + + E E S +W + + +G Sbjct: 31 WSSTD---VLAVALGKSIFLTDNNTGD--VVHLCDTENEYTSLSW-IGAGSHLAVGQANG 84 Query: 128 SIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQ 187 ++I+ ++++ + TL S + + V ++ H Sbjct: 85 LVEIYDVMKRKCIRTL---------------------------SGHIDRVACLSWNNH-- 115 Query: 188 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 247 ++ S S + D+R+P + + E +N +A+GG DN + + Sbjct: 116 -VLTSGSRDHRILHRDVRMPDPFFET--IESHTQEVCGLKWN-VADNKLASGGNDNVVHV 171 Query: 248 WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSAS--YD 305 ++ S + H A++ + WSPH +L + D Sbjct: 172 YE--------------------GTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTAD 211 Query: 306 MTCRIWRDLSNDGAKETYKTNS------TDATKGSIFNFT-------------------- 339 +IW ++ + + + T + + Sbjct: 212 RRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAIL 271 Query: 340 -QHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 HS V S G V S A D L W Sbjct: 272 KGHSFRVLHLTLSNDGTT--VVSGAGDETLRYWK 303 Score = 42.6 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 27/127 (21%), Positives = 53/127 (41%), Gaps = 11/127 (8%) Query: 13 GVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESH 72 + +SP LA G+ + +L I ++ S ++ +++S +Q C ++ W+++ Sbjct: 192 AMAWSPHKRGVLATGGGT-----ADRRLKIWNVNTSIKMSDIDSG-SQIC--NMVWSKNT 243 Query: 73 ENQVLVAQGDG-TLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKI 131 V L L+D + PIAI K H V + +S + D +++ Sbjct: 244 NELVTSHGYSKYNLTLWDCNSMD-PIAILKGHSFRVLHLTLSND-GTTVVSGAGDETLRY 301 Query: 132 WSPLRKQ 138 W K Sbjct: 302 WKLFDKP 308 >3JZG-A nrPDB Length = 402 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 45/253 (17%), Positives = 99/253 (39%), Gaps = 22/253 (8%) Query: 130 KIW--SPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQ 187 W L+ + I ++++P+ +K + N + + +F P D Sbjct: 111 CAWTYDSNTSHPLLAV-AGSRGIIRIINPITMQCIKH-----YVGHGNAINELKFHPRDP 164 Query: 188 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 247 NL+LS S + L++I+ + + E L+ D++ ++ + G+D+++++ Sbjct: 165 NLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM-SCGMDHSLKL 223 Query: 248 WDI---RMLNKNESATIKRTVPGQLHNSSCINEIP-----NAHGLAIRKVTWSPHHSNIL 299 W I RM+N + + S P + H + V W +++ Sbjct: 224 WRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL---GDLI 280 Query: 300 MSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYV 359 +S S + W+ + + K + ++ T F+++Q + W K + Sbjct: 281 LSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQK--ML 338 Query: 360 ASTAWDGNLFVWN 372 A G L+VW+ Sbjct: 339 ALGNQVGKLYVWD 351 Score = 56.5 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 51/376 (13%), Positives = 117/376 (31%), Gaps = 81/376 (21%) Query: 32 FGLVGNGKLFILEIDRSGRIVEVNSFLTQDCL---FDLAW---NESHENQVLVAQGDGTL 85 F VG+ ++ + E G I + S++ D + AW + + + VA G + Sbjct: 74 FATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGII 133 Query: 86 RLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTP 145 R+ + + I + H + ++ + LS S D ++++W+ + Sbjct: 134 RIINPITMQC-IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV----- 187 Query: 146 RPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLF--- 202 F G+ +R+ V A + + ++ SC + L+ Sbjct: 188 -------------------AIFGGVEGHRDEVLSADYDLLGEKIM-SCGMDHSLKLWRIN 227 Query: 203 -----------------DIRLPSGKNQNNFLVHSG--LEALTCDFNKYRPYVVATGGVDN 243 P + +F S + D ++ ++ + +N Sbjct: 228 SKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCEN 287 Query: 244 AIRIWDI----RMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH-SNI 298 AI W ++K + + T+ G+ S C I + +S + Sbjct: 288 AIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQC----------DIWYMRFSMDFWQKM 337 Query: 299 LMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGY 358 L + +W + K + + + +S Sbjct: 338 LALGNQVGKLYVWDL----------EVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSS--I 385 Query: 359 VASTAWDGNLFVWNGL 374 + + D +++ W+ L Sbjct: 386 LIAVCDDASIWRWDRL 401 >4U1E-I nrPDB Length = 347 Score = 59.5 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 37/260 (14%), Positives = 85/260 (32%), Gaps = 38/260 (14%) Query: 68 WNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDG 127 + + D + ++ + + H ++S + + + ++ S D Sbjct: 17 KYNKEGDLLFSCSKDSSASVW-YSLNGERLGTLDGHTGTIWSIDVDC-FTKYCVTGSADY 74 Query: 128 SIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQ 187 SIK+W Q + T K P+ + ++ N + +P Sbjct: 75 SIKLWDVSNGQCVAT--------WKSPVPVKRVEFSPCGNYFLAILDNVMK----NPGSI 122 Query: 188 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 247 N+ ++ ++ S + + + H GL+A T + + G D I Sbjct: 123 NIY---EIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISK 179 Query: 248 WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMT 307 +D+ + + + H +I + +SP +++S D T Sbjct: 180 YDVSNNYEYVDSI-------------------DLHEKSISDMQFSP-DLTYFITSSRD-T 218 Query: 308 CRIWRDLSNDGAKETYKTNS 327 D+S + Y+T+ Sbjct: 219 NSFLVDVSTLQVLKKYETDC 238 Score = 41.8 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 89/271 (32%), Gaps = 33/271 (12%) Query: 14 VQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVE--------VNSFLTQDCL-- 63 V++SP + LA+ + G + I EI+R E ++ +T + L Sbjct: 99 VEFSPCGNYFLAILDNV---MKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDA 155 Query: 64 FDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSS 123 +A + ++ DG + +D + + HE+ + ++ F++S Sbjct: 156 ATVAGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLT-YFITS 214 Query: 124 SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFS 183 S D + + Q L T ++ PL I+ + +F Sbjct: 215 SRDTNSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKF- 273 Query: 184 PHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDN 243 + Y +F+ + G+ Q +F T + A+GG D Sbjct: 274 ---EARF-------YHKIFEEEI--GRVQGHF-----GPLNTVAISPQGTSY-ASGGEDG 315 Query: 244 AIRIWDIRMLNKNESATIKRTVPGQLHNSSC 274 IR+ + +++ + H Sbjct: 316 FIRLHHFEKSYFDFKYDVEKAAEAKEHMQEA 346 >5A9Q-0 nrPDB Length = 380 Score = 58.4 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 30/207 (14%), Positives = 66/207 (31%), Gaps = 22/207 (10%) Query: 116 NRQNFLSSSWDGSIKIW--------------SPLRKQSLMTLTPRPLEITKMVDPLNAII 161 N ++ DG I ++ ++ L + + L Sbjct: 140 NNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWD 199 Query: 162 LK-----KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFL 216 + ++ +R ++ P+ Q++V + + S++D+R G + L Sbjct: 200 FRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVR--QGTMPVSLL 257 Query: 217 VHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCIN 276 E F+ P + T D ++ WD +S+ + S I+ Sbjct: 258 KAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSIS 317 Query: 277 EIPNAHGLAIRK-VTWSPHHSNILMSA 302 N H I ++ P I +++ Sbjct: 318 NQANVHQSVISSWLSTDPAKDRIEITS 344 Score = 55.3 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 34/69 (49%) Query: 68 WNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDG 127 + + ++ V DG L ++D P+++ K HE E++ +++ N ++ + S DG Sbjct: 225 RHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDG 284 Query: 128 SIKIWSPLR 136 S+ W Sbjct: 285 SLWHWDAST 293 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 27/135 (20%), Positives = 51/135 (37%), Gaps = 22/135 (16%) Query: 190 VLSCSGNSYASLFDIRLPSGKNQNNFLVHSG--LEALTCDFNKYRPYVVATGGVDNAIRI 247 +L+ + ++D R G + L +G + D + + +VVATGG D + I Sbjct: 186 ILTVNSIGQLKIWDFR-QQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSI 244 Query: 248 WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMT 307 WD+R + + AH + +V + P + L + S D + Sbjct: 245 WDVR-------------------QGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGS 285 Query: 308 CRIWRDLSNDGAKET 322 W ++ K + Sbjct: 286 LWHWDASTDVPEKSS 300 >3F3P-A nrPDB Length = 351 Score = 58.0 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 48/354 (13%), Positives = 111/354 (31%), Gaps = 69/354 (19%) Query: 58 LTQDCLFDLAWNESHENQVLVAQGDGTLRLFDT---TFKEFPIAIFKEHEREVFSCNWNL 114 L D ++D + V D +++F T ++ H+ + + +W Sbjct: 13 LVHDVVYDF-----YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 115 V-NRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 173 + S+S+D ++K+W + D + ++ + Sbjct: 68 PEYGRIIASASYDKTVKLWE------------------EDPDQEECSGRRWNKLCTLNDS 109 Query: 174 RNCVYQAQFSPHDQNL-VLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYR 232 + +Y +F+P L + + L+D PS + ++ + Sbjct: 110 KGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS 169 Query: 233 PYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWS 292 + ++ + L + G+ ++P H IR ++W+ Sbjct: 170 DFCLSWCPSR-----FSPEKLAVSALEQAIIYQRGKDGKLHVAAKLP-GHKSLIRSISWA 223 Query: 293 PHHSN---ILMSASYDMTCRIWR---DLSNDGAKET----------------YKTNSTDA 330 P ++ + D RI++ LS ++E+ + S Sbjct: 224 PSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSN 283 Query: 331 TK-----------GSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 T+ + H+ V+ W+L G ++S DG + +W Sbjct: 284 TEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT--ILSSAGDDGKVRLWKA 335 Score = 47.6 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 24/146 (16%), Positives = 54/146 (36%), Gaps = 24/146 (16%) Query: 230 KYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKV 289 + VAT D I+++ + + ++ +++ AH +I + Sbjct: 20 DFYGRHVATCSSDQHIKVFKL----------------DKDTSNWELSDSWRAHDSSIVAI 63 Query: 290 TW-SPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGA 348 W SP + I+ SASYD T ++W ++ + + + ++ Sbjct: 64 DWASPEYGRIIASASYDKTVKLW-------EEDPDQEECSGRRWNKLCTLNDSKGSLYSV 116 Query: 349 DWSLWGKPGYVASTAWDGNLFVWNGL 374 ++ +A DG L +++ L Sbjct: 117 KFAPAHLGLKLACLGNDGILRLYDAL 142 Score = 30.6 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 33/98 (33%), Gaps = 13/98 (13%) Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 334 + + H + V + + + + S D ++ +K + + Sbjct: 3 MQPFDSGHDDLVHDVVYDFYG-RHVATCSSDQHIKV------------FKLDKDTSNWEL 49 Query: 335 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 ++ H + DW+ +AS ++D + +W Sbjct: 50 SDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWE 87 >5OQL-X nrPDB Length = 630 Score = 57.6 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 42/249 (16%), Positives = 76/249 (30%), Gaps = 22/249 (8%) Query: 72 HENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKI 131 V+ D L +++ + PI F +H V + Q S S D ++K+ Sbjct: 257 DGKFVVTGGADKRLVVYNAADLK-PIKAFTQHRDAVTGLAFRRGTNQ-LYSCSKDRTVKV 314 Query: 132 WSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 191 WS + TL EI + + + ++ P + LV Sbjct: 315 WSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKV-------PEESQLVF 367 Query: 192 SCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKY-RPYVVATGGVDNAIRIWDI 250 G +S K S + D + TG + + +W I Sbjct: 368 RGGGEGGSS----NTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDLALWSI 423 Query: 251 RMLN-------KNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSAS 303 + + + + IP I + P+ S+++ S S Sbjct: 424 QRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPY-SDLIFSGS 482 Query: 304 YDMTCRIWR 312 +D R+WR Sbjct: 483 WDGCIRVWR 491 Score = 50.3 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 36/268 (13%), Positives = 79/268 (29%), Gaps = 48/268 (17%) Query: 21 DNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQ-DCLFDLAWNESHENQVLVA 79 D + V G++ LV + + + + +F D + LA+ NQ+ Sbjct: 257 DGKFVVTGGADKRLV---------VYNAADLKPIKAFTQHRDAVTGLAFRRG-TNQLYSC 306 Query: 80 QGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQS 139 D T++++ + + H+ E+ + L + + D + + W + Sbjct: 307 SKDRTVKVWSLD-ELAYVETLFGHQDEILDID-ALGQERCVSVGARDRTARYWKVPEESQ 364 Query: 140 LMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYA 199 L+ L + + + + D ++ ++ S N Sbjct: 365 LVFRGGGEGG----SSNTKKHKLPPGMDPASAAHEGSMDRVAM--IDDDMFVTGSDNGDL 418 Query: 200 SLFDIRLPSGKNQNNFLVHSGLEA--------------------------LTCDFNKYRP 233 +L+ I+ K + GLE Y Sbjct: 419 ALWSIQRK--KPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSD 476 Query: 234 YVVATGGVDNAIRIWDIRMLNKNESATI 261 + +G D IR+W + + A Sbjct: 477 LIF-SGSWDGCIRVWRLSEDKRKLEAVG 503 Score = 41.8 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 31/224 (13%), Positives = 63/224 (28%), Gaps = 33/224 (14%) Query: 168 TGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKN-----QNNFLVHSGLE 222 +++R+ V F N + SCS + ++ + + Q+ L L Sbjct: 282 KAFTQHRDAVTGLAFR-RGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALG 340 Query: 223 ALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSC---INEIP 279 C V+ G D R W + ++ ++ Sbjct: 341 QERC---------VSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPAS 391 Query: 280 NAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND---------GAKETYKTN--ST 328 AH ++ +V ++ ++ S + +W G + K S Sbjct: 392 AAHEGSMDRVAM--IDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSA 449 Query: 329 DATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 D + + + S +WDG + VW Sbjct: 450 DEIPDPSIIPAPQPRGITALRTLPYSD--LIFSGSWDGCIRVWR 491 >5MWJ-A nrPDB Length = 337 Score = 56.5 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 46/332 (13%), Positives = 98/332 (29%), Gaps = 73/332 (21%) Query: 66 LAWNESHENQVLVAQGDGTLRLFDTTF--KEFPIAIFK--EHEREVFSCNWNLVNRQNFL 121 A S+ + + G G ++++D + + P++ + + SC L + + Sbjct: 55 CAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKL-LPDGCTLI 113 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQ 181 ++ IW + P + ++ + Y Sbjct: 114 VGGEASTLSIWD-------------------LAAPT------PRIKAELTSSAPACYALA 148 Query: 182 FSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGV 241 SP D + SC + +++D+ + Q F H+ A D + TGG+ Sbjct: 149 ISP-DSKVCFSCCSDGNIAVWDLHNQTLVRQ--FQGHTDG-ASCIDI-SNDGTKLWTGGL 203 Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHH------ 295 DN +R WD+R + + + + + + + + Sbjct: 204 DNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHL 263 Query: 296 -------------SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHS 342 +S D WR G+ ++ S Sbjct: 264 HESCVLSLKFAYCGKWFVSTGKDNLLNAWRT-----------------PYGASIFQSKES 306 Query: 343 EFVFGADWSLWGKPGYVASTAWDGNLFVWNGL 374 V D S+ K Y+ + + D V+ + Sbjct: 307 SSVLSCDISVDDK--YIVTGSGDKKATVYEVI 336 >5BJS-A nrPDB Length = 605 Score = 55.7 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 26/188 (13%), Positives = 56/188 (29%), Gaps = 17/188 (9%) Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFL---VHSGLEALTCDF 228 + + SP + ++ S S ++ ++ + K + + L+ F Sbjct: 176 GHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAF 235 Query: 229 NKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRK 288 + V + G D I +W + +S H + Sbjct: 236 HD-NGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEI-------HNNLVDC 287 Query: 289 VTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGA 348 V + IL A ++ T +WR + + + T + T+ + F Sbjct: 288 VAFY--GDLILSRACHEDTIVLWR-IEGFSSDDPIPGPLDAPTPTDM---TKQTRSYFTP 341 Query: 349 DWSLWGKP 356 S +P Sbjct: 342 TVSPQSRP 349 Score = 46.8 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 28/241 (11%), Positives = 73/241 (30%), Gaps = 41/241 (17%) Query: 46 DRSGRIVEVNSFLTQDC-LFDL--AWNE---SHENQVLVAQGDGTLRLFDTTFKEFPIAI 99 D+ E+ + D + W++ + + + +A +G +++++ T + Sbjct: 115 DKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKL-YRT 173 Query: 100 FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNA 159 H + + N S+S D +I+IW L P Sbjct: 174 LVGHGGGINDLATSPANPYIIASASDDTTIRIW--------------SLAPEHEKQPCVC 219 Query: 160 IILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQN------ 213 I+ G + + F + + ++ S + +L+ + ++ Sbjct: 220 IL-------GGEGHSYDLLSVAFHDNGRYVL-SAGHDQVINLWALPEFPNEHMEIPIVIY 271 Query: 214 ----NFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQL 269 + F Y +++ ++ I +W I + ++ P Sbjct: 272 YPHFSSSEIHNNLVDCVAF--YGDLILSRACHEDTIVLWRIEGFSSDDPIPGPLDAPTPT 329 Query: 270 H 270 Sbjct: 330 D 330 Score = 43.0 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 23/97 (23%), Positives = 33/97 (34%), Gaps = 12/97 (12%) Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 334 + HG I + SP + I+ SAS D T RIW + Sbjct: 170 LYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW----------SLAPEHEKQPCVC 219 Query: 335 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 I HS + + G+ YV S D + +W Sbjct: 220 ILGGEGHSYDLLSVAFHDNGR--YVLSAGHDQVINLW 254 Score = 31.8 bits (70), Expect = 0.54, Method: Composition-based stats. Identities = 7/33 (21%), Positives = 13/33 (39%), Gaps = 1/33 (3%) Query: 340 QHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H + S P +AS + D + +W+ Sbjct: 176 GHGGGINDLATSPAN-PYIIASASDDTTIRIWS 207 >5N4A-A nrPDB Length = 771 Score = 54.5 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 45/294 (15%), Positives = 86/294 (29%), Gaps = 70/294 (23%) Query: 103 HEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIIL 162 H + WN+ N + S D +I W+ L + T P+++ Sbjct: 13 HSELTAAVGWNVWNE--LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSS--- 67 Query: 163 KKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLE 222 KK G ++ + + +G+ + + H G Sbjct: 68 KKTQAGG-----------------TDVFAVACTDGSVKIL---SRTGRVEKSIEGHKGA- 106 Query: 223 ALTCDFN-KYRPYVVATGGVDNAIRIWD----IRMLNKNESATIKRTVPGQLHNSSCINE 277 Y +AT G D +++IW +R + + V + C Sbjct: 107 --CISLRWSYDGTALATAGEDGSVKIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCT 164 Query: 278 IPN----------------AHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKE 321 N AH + KV WSP + +++++ D ++W Sbjct: 165 GSNVVIKSLSSNAKQNAWKAHDGVVLKVDWSPIN-HLIITGGEDCKYKVW---------- 213 Query: 322 TYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG 375 D+ +F V W+ G+ V L + + +G Sbjct: 214 -------DSFGRLLFQSGLFDYPVTSVAWAPSGELFAVGGF---NTLQLCDRMG 257 Score = 34.5 bits (77), Expect = 0.083, Method: Composition-based stats. Identities = 29/165 (17%), Positives = 53/165 (32%), Gaps = 35/165 (21%) Query: 211 NQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLH 270 Q++ VHS L A +N + + T D I W++ + + +T+ Sbjct: 6 KQSSANVHSELTA-AVGWNVWNE--LFTCSDDQTIHKWNMLGEPEQKVSTLDAY------ 56 Query: 271 NSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDA 330 + H + +++ A D + +I LS G E Sbjct: 57 -------FTDMHWYPVSSKKTQAGGTDVFAVACTDGSVKI---LSRTGRVEKSI------ 100 Query: 331 TKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG 375 H WS G +A+ DG++ +W+ G Sbjct: 101 --------EGHKGACISLRWSYDGTA--LATAGEDGSVKIWSRNG 135 >3ACP-A nrPDB Length = 417 Score = 54.5 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 29/245 (11%), Positives = 74/245 (30%), Gaps = 38/245 (15%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 ++ + D L+++ P H V + +N LS+S DG+I+ Sbjct: 146 PSGEALISSSQDMQLKIWSVKDGSNP-RTLIGHRATVTDIAI-IDRGRNVLSASLDGTIR 203 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 190 +W ++ T + + + ++ + +N + + + V Sbjct: 204 LWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKY----V 259 Query: 191 LSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKY-----RPYVVATGGVDNAI 245 ++ + ++ ++ TC N + G + + Sbjct: 260 IAGHVSGVITVHNVFSKE-------QTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGML 312 Query: 246 RIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYD 305 WD+R + E G I V ++ + +S+ +D Sbjct: 313 AQWDLRSPECP------------------VGEFLINEGTPINNVYFAA--GALFVSSGFD 352 Query: 306 MTCRI 310 + ++ Sbjct: 353 TSIKL 357 Score = 44.1 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 37/217 (17%), Positives = 63/217 (29%), Gaps = 45/217 (20%) Query: 156 PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNF 215 LN I K G S+ + F +L + LF+ + G Sbjct: 35 NLNEIKEHKIVVLGNSRGVDAGKGNTFEKVGSHLYKARLDGHDF-LFNTIIRDGSKMLKR 93 Query: 216 LVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCI 275 ++ ++ ++ G + I++ D N + Sbjct: 94 ADYTAVDTAKLQMRRF-----ILGTTEGDIKVLD--------------------SNFNLQ 128 Query: 276 NEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSI 335 EI AH I K+ + P L+S+S DM +IW + Sbjct: 129 REIDQAHVSEITKLKFFPSGEA-LISSSQDMQLKIWSVKDGSNPRTLI------------ 175 Query: 336 FNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 H V G+ V S + DG + +W Sbjct: 176 ----GHRATVTDIAIIDRGRN--VLSASLDGTIRLWE 206 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 25/186 (13%), Positives = 47/186 (25%), Gaps = 31/186 (16%) Query: 193 CSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRM 252 + + D + + E F + + D ++IW ++ Sbjct: 112 GTTEGDIKVLDSNFNLQREIDQ---AHVSEITKLKFFP-SGEALISSSQDMQLKIWSVKD 167 Query: 253 LNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 312 + + H + + N+L SAS D T R+W Sbjct: 168 GSNPRTLI--------------------GHRATVTDIAIIDRGRNVL-SASLDGTIRLWE 206 Query: 313 DLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGK------PGYVASTAWDG 366 + + + SI F + S YV + G Sbjct: 207 CGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSG 266 Query: 367 NLFVWN 372 + V N Sbjct: 267 VITVHN 272 Score = 34.1 bits (76), Expect = 0.088, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 45/110 (40%), Gaps = 15/110 (13%) Query: 26 VAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTL 85 V AG G++ +F E + +++ S T C L + ++ N + +G L Sbjct: 259 VIAGHVSGVITVHNVFSKE-----QTIQLPSKFTCSC-NSLTVDGNNANYIYAGYENGML 312 Query: 86 RLFDTTFKEFPIAIFKEHE----REVFSCNWNLVNRQNFLSSSWDGSIKI 131 +D E P+ F +E V+ F+SS +D SIK+ Sbjct: 313 AQWDLRSPECPVGEFLINEGTPINNVY-----FAAGALFVSSGFDTSIKL 357 >5OV3-A nrPDB Length = 381 Score = 53.0 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 44/331 (13%), Positives = 85/331 (25%), Gaps = 47/331 (14%) Query: 59 TQDCLF---DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLV 115 T DC+ +N + V DG + ++D + I H V S W+ Sbjct: 21 TLDCISMALTCTFNR-WGTLLAVGCNDGRIVIWDFLTRGI-AKIISAHIHPVCSLCWSRD 78 Query: 116 NRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRN 175 +S+S D + W L + + P+ + + + Sbjct: 79 -GHKLVSASTDNIVSQWDVLSGDCD--------QRFRFPSPILKVQYHPRDQNKVLVCPM 129 Query: 176 CVYQAQFSPHDQ-NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPY 234 + D ++VL +S ++ G+ + L D Sbjct: 130 KSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVAS 189 Query: 235 VVATGGVDNAIRIWDIRMLNKN--ESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVT-- 290 T G N I I K + + + ++K+ Sbjct: 190 FRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDL 249 Query: 291 ----------WSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQ 340 +S I+ ++ IW + K Sbjct: 250 VNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVK---------------ILHGT 294 Query: 341 HSEFVFGADWSLWGKPGYVASTAWDGNLFVW 371 E + W +AS + G + +W Sbjct: 295 RGELLLDVAWHPV--RPIIASISS-GVVSIW 322 Score = 39.5 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 26/197 (13%), Positives = 70/197 (35%), Gaps = 17/197 (8%) Query: 188 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 247 L+ + ++D L G + ++ + + + + + + DN + Sbjct: 38 TLLAVGCNDGRIVIWDF-LTRGIAK---IISAHIHPVCSLCWSRDGHKLVSASTDNIVSQ 93 Query: 248 WDIRMLNKNESATIKRTVPGQLHNSSCINEI---PNAHGLAIRKVTWSPH-------HSN 297 WD+ + ++ + ++ N++ P + ++ S H S+ Sbjct: 94 WDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSD 153 Query: 298 ILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKG-SIFNFTQHSEFVFGADWSLWGKP 356 + + AS+D + G KT+S D + T ++ + +++ G Sbjct: 154 LNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSC 213 Query: 357 GYVASTAWDGNLFVWNG 373 + + D + V++G Sbjct: 214 FLINTA--DRIIRVYDG 228 Score = 31.0 bits (68), Expect = 0.85, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 23/79 (29%), Gaps = 18/79 (22%) Query: 296 SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGK 355 +L D IW L+ AK + H V WS G Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAK----------------IISAHIHPVCSLCWSRDGH 80 Query: 356 PGYVASTAWDGNLFVWNGL 374 + S + D + W+ L Sbjct: 81 K--LVSASTDNIVSQWDVL 97 >5A31-R nrPDB Length = 386 Score = 53.0 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 51/334 (15%), Positives = 102/334 (30%), Gaps = 90/334 (26%) Query: 68 WNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDG 127 W+ + VL ++ L D + + + E E S +W + + +G Sbjct: 100 WSSTD---VLAVALGKSIFLTDNNTGD--VVHLCDTENEYTSLSW-IGAGSHLAVGQANG 153 Query: 128 SIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQ 187 ++I+ ++++ + TL S + + V ++ H Sbjct: 154 LVEIYDVMKRKCIRTL---------------------------SGHIDRVACLSWNNH-- 184 Query: 188 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 247 ++ S S + D+R+P + + E +N +A+GG DN + + Sbjct: 185 -VLTSGSRDHRILHRDVRMPDPFFET--IESHTQEVCGLKWN-VADNKLASGGNDNVVHV 240 Query: 248 WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSAS--YD 305 ++ S + H A++ + WSPH +L + D Sbjct: 241 YE--------------------GTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTAD 280 Query: 306 MTCRIWRDLSNDGAKETYKTNS------TDATKGSIFNFT-------------------- 339 +IW ++ + + + T + + Sbjct: 281 RRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAIL 340 Query: 340 -QHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 HS V S G V S A D L W Sbjct: 341 KGHSFRVLHLTLSNDGTT--VVSGAGDETLRYWK 372 Score = 51.8 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 30/188 (15%), Positives = 61/188 (32%), Gaps = 35/188 (18%) Query: 65 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS-- 122 L WN + +N++ D + +++ T K PI F EH+ V + W+ R + Sbjct: 219 GLKWNVA-DNKLASGGNDNVVHVYEGTSK-SPILTFDEHKAAVKAMAWSPHKRGVLATGG 276 Query: 123 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQF 182 + D +KIW+ + + + ++ K + ++ + Y Sbjct: 277 GTADRRLKIWNVNTSIKMSDIDSGSQ--------ICNMVWSKNTNELVTSHGYSKYN--- 325 Query: 183 SPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVD 242 +L+D + + L L V +G D Sbjct: 326 ----------------LTLWDC---NSMDPIAILKGHSFRVLHLTL-SNDGTTVVSGAGD 365 Query: 243 NAIRIWDI 250 +R W + Sbjct: 366 ETLRYWKL 373 Score = 51.1 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 43/290 (14%), Positives = 96/290 (33%), Gaps = 60/290 (20%) Query: 26 VAAGSNFGL-VGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGT 84 + AGS+ + NG + I ++ + I ++ + D + L+WN + + D Sbjct: 140 IGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHI--DRVACLSWN---NHVLTSGSRDHR 194 Query: 85 LRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT 144 + D + + H +EV WN V S D + ++ K ++T Sbjct: 195 ILHRDVRMPDPFFETIESHTQEVCGLKWN-VADNKLASGGNDNVVHVYEGTSKSPILTFD 253 Query: 145 PRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSG--NSYASLF 202 +++ V +SPH + ++ + G + ++ Sbjct: 254 ---------------------------EHKAAVKAMAWSPHKRGVLATGGGTADRRLKIW 286 Query: 203 DIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIK 262 ++ + ++ S + + N V + G + +WD ++ Sbjct: 287 NV--NTSIKMSDIDSGSQICNMVWSKN-TNELVTSHGYSKYNLTLWDCNSMDPIA----- 338 Query: 263 RTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 312 I H + +T S + + +S + D T R W+ Sbjct: 339 ---------------ILKGHSFRVLHLTLSNDGTTV-VSGAGDETLRYWK 372 >3DW8-B nrPDB Length = 447 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 45/282 (15%), Positives = 91/282 (32%), Gaps = 38/282 (13%) Query: 114 LVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 173 N FL S+ D +IK+W + E + DP L+ F + Sbjct: 104 QKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLM 163 Query: 174 RNCVYQAQFSPHDQNLVLSCS-----------GNSYASLF------------DIRLPSGK 210 + F+ + S S + +L+ DI+ + + Sbjct: 164 VEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANME 223 Query: 211 NQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLH 270 + + +C+ Y IR+ D+R + + P Sbjct: 224 ELTEVITAAEFHPNSCNTFVYS-------SSKGTIRLCDMRASALCDRHSKLFEEPEDPS 276 Query: 271 NSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDA 330 N S +EI + +I V +S H +M+ Y ++ ++W + ETY+ + Sbjct: 277 NRSFFSEIIS----SISDVKFS-HSGRYMMTRDY-LSVKVWDLNMENRPVETYQVHEYLR 330 Query: 331 TKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 +K F W+ G V + +++ +++ Sbjct: 331 SKLCSLYENDCIFDKFECCWN--GSDSVVMTGSYNNFFRMFD 370 >4J0W-A nrPDB Length = 343 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 39/305 (12%), Positives = 82/305 (26%), Gaps = 70/305 (22%) Query: 97 IAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT-----------P 145 I + + H+ + S++ D SI WS + L + Sbjct: 7 IRVLRGHQLSITCLVVTPD-DSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG 65 Query: 146 RPLEITKM---VDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNL-----------VL 191 + M D + I + ++C + F+ H + + Sbjct: 66 HSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLY 125 Query: 192 SCSGNSYASLFDIRLPSGKN-----QNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIR 246 S S + ++++ S Q+ L C V GG D +R Sbjct: 126 STSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECC---------VTAGGRDGTVR 176 Query: 247 IWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDM 306 +W I ++ H +I + + ++S + D Sbjct: 177 VWKIPEESQLVFY---------------------GHQGSIDCIHL--INEEHMVSGADDG 213 Query: 307 TCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDG 366 + +W + + G F ++ L VA+ + Sbjct: 214 SVALWGLSKKRPLALQREAHGLRGEPGLEQPF-----WISSVAALLNTD--LVATGSHSS 266 Query: 367 NLFVW 371 + +W Sbjct: 267 CVRLW 271 Score = 51.4 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 40/220 (18%), Positives = 82/220 (37%), Gaps = 29/220 (13%) Query: 36 GNGKLFILEIDRSGRIVEVNS-------FLTQDCLFDLAWNESHENQVLVAQGDGTLRLF 88 G +L+ DRS ++ V F QD + L S E V DGT+R++ Sbjct: 120 GTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALD-ALSRECCVTAGGRDGTVRVW 178 Query: 89 DTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPL 148 E +F H+ + +L+N ++ +S + DGS+ +W +K+ P L Sbjct: 179 KIP--EESQLVFYGHQGSIDCI--HLINEEHMVSGADDGSVALWGLSKKR------PLAL 228 Query: 149 EITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPS 208 + + + + ++ + + +LV + S +S L+ Sbjct: 229 QREAHGLRGEPGLEQPFWISSVA-----------ALLNTDLVATGSHSSCVRLWQCGEGF 277 Query: 209 GKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 + + + F+ ++VA G ++ + W Sbjct: 278 RQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRW 317 >5K0Y-T nrPDB Length = 329 Score = 51.1 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 41/328 (12%), Positives = 90/328 (27%), Gaps = 58/328 (17%) Query: 68 WNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDG 127 + + D + ++ + + + H V+ + + ++ L+ S D Sbjct: 17 KYNREGDLLFTVAKDPIVNVW-YSVNGERLGTYMGHTGAVWCVDADWD-TKHVLTGSADN 74 Query: 128 SIKIWSPLRKQSLMTLTPRPLEITKMVD-------------------------PLNAIIL 162 S ++W + L L T D + I Sbjct: 75 SCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQID 134 Query: 163 KKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLE 222 + + I N + + A + P + ++ +G+ L SG+ N HS + Sbjct: 135 NNEPYMKIPCNDSKITSAVWGPLGECII---AGHESGELNQYSAKSGEVLVNVKEHSR-Q 190 Query: 223 ALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAH 282 + T DN +++D L ++ + + + + + Sbjct: 191 INDIQL-SREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAALSPNYEHVVVGG- 248 Query: 283 GLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHS 342 G VT + G E + A + H Sbjct: 249 GQEAMDVT---------------------TTSTRIGKFEARFFHL--AFEEEFGRVKGHF 285 Query: 343 EFVFGADWSLWGKPGYVASTAWDGNLFV 370 + + GK +S DG + + Sbjct: 286 GPINSVAFHPDGKSY--SSGGEDGYVRI 311 Score = 41.0 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 37/84 (44%), Gaps = 5/84 (5%) Query: 172 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKY 231 + + Q +++ L+ + + + +++ +G+ ++ H+G A+ C + Sbjct: 8 GHERSITQIKYNREGD-LLFTVAKDPIVNVW--YSVNGERLGTYMGHTG--AVWCVDADW 62 Query: 232 RPYVVATGGVDNAIRIWDIRMLNK 255 V TG DN+ R+WD + Sbjct: 63 DTKHVLTGSADNSCRLWDCETGKQ 86 Score = 34.5 bits (77), Expect = 0.069, Method: Composition-based stats. Identities = 12/97 (12%), Positives = 34/97 (35%), Gaps = 23/97 (23%) Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFN 337 + H +I ++ ++ +L + + D +W ++ + Sbjct: 5 LLQGHERSITQIKYNREGD-LLFTVAKDPIVNVWYSVNG----------------ERLGT 47 Query: 338 FTQHSEFVFGADWSLWGK--PGYVASTAWDGNLFVWN 372 + H+ GA W + +V + + D + +W+ Sbjct: 48 YMGHT----GAVWCVDADWDTKHVLTGSADNSCRLWD 80 >1PI6-A nrPDB Length = 615 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 54/394 (13%), Positives = 116/394 (29%), Gaps = 51/394 (12%) Query: 4 YHMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSG---RIVEVNSFLTQ 60 +H QG V++SP +G VG+ + +SG + +E + Q Sbjct: 202 HHKQGSFVRDVEFSP--------DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQ 253 Query: 61 DCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEF-PIAIFKEHEREVFSCNWNLVNRQN 119 +F L+W +S + D T+R++D T + + + Sbjct: 254 GGIFALSWLDSQ--KFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR 311 Query: 120 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQ 179 +S S DG++ + + L T++ IT + S Sbjct: 312 IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSS------- 364 Query: 180 AQFSPHDQNLVLSC-----------SGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDF 228 + NL++S S + + I +Q + Sbjct: 365 SSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLT 424 Query: 229 NKYRPYVVATGGVD--NAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAI 286 N ++ + D ++R+ + + + V L + I + Sbjct: 425 NDDDLLILQSFTGDIIKSVRL----NSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 Query: 287 RKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVF 346 + +S S T D+ ++ ++ + + + Sbjct: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAF-----RTSKIN 535 Query: 347 GADWSLWGK--------PGYVASTAWDGNLFVWN 372 W K VA+ + D N+F+++ Sbjct: 536 AISWKPAEKGANEEEIEEDLVATGSLDTNIFIYS 569 Score = 45.7 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 46/291 (15%), Positives = 83/291 (28%), Gaps = 59/291 (20%) Query: 86 RLFDTTFKEFPIAIFKEH-EREVFSCNWNLVNR-QNFLSSSWDGSIKIWS-PLRKQSLMT 142 L D K P+ F H V + ++ + Q S G + +W K+S Sbjct: 45 CLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSV 104 Query: 143 LTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASL- 201 E + P++ I F +V N + Sbjct: 105 EVNVKSEFQVLAGPISDISWD------------------FEGRRLCVVGEGRDNFGVFIS 146 Query: 202 FDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATI 261 +D G+ + C + RP T G D ++ + Sbjct: 147 WDSGNSLGE-----VSGHSQRINACHLKQSRPMRSMTVGDDGSVVFY------------- 188 Query: 262 KRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKE 321 G S + + G +R V +SP +++ D + S + K Sbjct: 189 ----QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLK- 243 Query: 322 TYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 Y + + +G +F W L + A+ D + VW+ Sbjct: 244 -YIEDDQEPVQGG----------IFALSW-LDSQKF--ATVGADATIRVWD 280 >5TF2-A nrPDB Length = 407 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 39/259 (15%), Positives = 70/259 (27%), Gaps = 48/259 (18%) Query: 71 SHENQVLVAQG-DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 129 +H+N +L G DG +R++ E + FK HE E+ ++ D Sbjct: 181 NHDNTLLATGGTDGYVRVWKVPSLEK-VLEFKAHEGEIEDLALGP--DGKLVTVGRDLKA 237 Query: 130 KIW--SPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQ 187 +W L Q T G+ + + Sbjct: 238 SVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPP 297 Query: 188 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 247 Y + +D G E ++C + G V ++ I Sbjct: 298 ---------CYLTAWD----GSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAI 344 Query: 248 WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH----------HSN 297 + + C+ + AHG+ + V + P H Sbjct: 345 Y-------------------IAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHET 385 Query: 298 ILMSASYDMTCRIWRDLSN 316 L S + D C++ S Sbjct: 386 ALFSVAVDSRCQLHLLPSR 404 Score = 38.0 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 30/101 (29%), Gaps = 22/101 (21%) Query: 212 QNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHN 271 Q S + ++ATGG D +R+W + L K Sbjct: 163 QAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEF------------ 210 Query: 272 SSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 312 AH I + P L++ D+ +W+ Sbjct: 211 --------KAHEGEIEDLALGPDGK--LVTVGRDLKASVWQ 241 >5WYJ-BE nrPDB Length = 939 Score = 49.1 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 41/283 (14%), Positives = 85/283 (30%), Gaps = 56/283 (19%) Query: 47 RSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHERE 106 R+ R+ T D N + +G++ +++ +K H+R Sbjct: 446 RNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILR-KKYKLHKRA 504 Query: 107 VFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKS 166 V + + +NR +S DG + + + L L K+ P+ A++ + S Sbjct: 505 VTGISLDGMNR-KMVSCGLDGIVGFYDFNKSTLLGKL--------KLDAPITAMVYHRSS 555 Query: 167 FTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTC 226 +L + + D + + HS Sbjct: 556 ---------------------DLFALALDDLSIVVIDA--VTQRVVRQLWGHSN-RITAF 591 Query: 227 DFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAI 286 DF+ + + +D+ IR WD+ CI+ I Sbjct: 592 DFSP-EGRWIVSASLDSTIRTWDL-------------------PTGGCIDGIIV--DNVA 629 Query: 287 RKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTD 329 V +SP+ + + IW + + T + ++ Sbjct: 630 TNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESE 672 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 58/369 (15%), Positives = 125/369 (33%), Gaps = 40/369 (10%) Query: 29 GSNFGLVG--NGKLFILEIDRSGRI-VEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTL 85 GS+ VG +G L ++DR RI V N A + + ++ + GD +L Sbjct: 260 GSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSL 319 Query: 86 R--LFDTTFKE-------FPIAIFK---EHEREVFSCNWNLVNRQNFLSSSWDGSIKIWS 133 + +FD + + P + H + + LS+S D S +WS Sbjct: 320 KEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRS--LWS 377 Query: 134 PLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSC 193 ++ + K K F I + A+ +N++ + Sbjct: 378 FSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVAL--AIENARIG-EWENIITAH 434 Query: 194 SGNSYASLFDIRLP-----SGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 +A +D+R + ++ V S + +F ++ G + +I I+ Sbjct: 435 KDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNF----GFI---GSSNGSITIY 487 Query: 249 DIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDM-- 306 +++ + + + + ++ + I + + S +L D Sbjct: 488 NMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGF-YDFNKSTLLGKLKLDAPI 546 Query: 307 TCRIW---RDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTA 363 T ++ DL + T+ + HS + D+S G+ ++ S + Sbjct: 547 TAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGR--WIVSAS 604 Query: 364 WDGNLFVWN 372 D + W+ Sbjct: 605 LDSTIRTWD 613 >5K19-A nrPDB Length = 569 Score = 48.8 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 41/261 (15%), Positives = 78/261 (29%), Gaps = 38/261 (14%) Query: 104 EREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILK 163 + V W + FL + G++ +++ + T L ++ K Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSSGNMYLYN-VEHTCGTTAPHYQLLKQGESFAVHTCKSK 207 Query: 164 KKSFTGI--SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGL 221 + + + + FSP + L S + + +F+ + + S Sbjct: 208 STRNPLLKWTVGEGALNEFAFSPDGKFLAC-VSQDGFLRVFNFDSVEL----HGTMKSYF 262 Query: 222 EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNA 281 L C + TGG D+ + +W + V + H Sbjct: 263 GGLLCVCWSPDGKYIVTGGEDDLVTVWS----------FVDCRVIARGH----------G 302 Query: 282 HGLAIRKVTWSP------HHSNILMSAS---YDMTCRIWRDLSNDGAKETYKTNSTDATK 332 H + V + P + S S + RD +N K NSTD+ Sbjct: 303 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRP 362 Query: 333 GSI-FNFTQHSEFVFGADWSL 352 S+ + F + W L Sbjct: 363 VSVTYRFGSVGQDTQLCLWDL 383 >6CB1-s nrPDB Length = 569 Score = 48.8 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 49/134 (36%), Gaps = 16/134 (11%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 + ++ + D + D P + HE+ V S N++ F S++ DG+I Sbjct: 452 PRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIH 510 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 190 ++ +M M+ PL + K + V A + P + L Sbjct: 511 VFHATVYDDMMKNP--------MIVPLKKLTGHKVINSL------GVLDAIWHPREAWLF 556 Query: 191 LSCSGNSYASLFDI 204 + + ++ A L+ Sbjct: 557 SAGA-DNTARLWTT 569 Score = 44.5 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 55/365 (15%), Positives = 105/365 (28%), Gaps = 80/365 (21%) Query: 76 VLVAQGDGTLRLFDTTFKEF--PIAIFKEHEREVF---SCNWNLVNRQNFLSSSWDGSI- 129 + DGT+R+++ + + E + WN L+ + +I Sbjct: 214 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 273 Query: 130 -----------------KIWSPLRKQSLMTLTPRPLEITKMVD----------------- 155 KI + T+ LE+ + D Sbjct: 274 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQ 333 Query: 156 -----PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK 210 + L+K IS + V + + V + S+ ++ Sbjct: 334 VAQWNKPSQKQLEKDICITISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHL 392 Query: 211 NQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI-------------------- 250 Q+ F G+ + F+ ++P + +RI+D+ Sbjct: 393 TQSPFKKSKGI-IMDAKFHPFKPQLFVC--SQRYVRIYDLSQQILVKKLLPGARWLSKID 449 Query: 251 ---RMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMT 307 R N S+ KR + L +S + H A+R V + + SA+ D T Sbjct: 450 IHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKK-LPLFSSAADDGT 508 Query: 308 CRI-WRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDG 366 + + +D K T + N V A W + ++ S D Sbjct: 509 IHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLG----VLDAIWHP--REAWLFSAGADN 562 Query: 367 NLFVW 371 +W Sbjct: 563 TARLW 567 Score = 41.0 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 58/351 (16%), Positives = 111/351 (31%), Gaps = 70/351 (19%) Query: 4 YHMQGFSGYGVQYSPFFDNR-LAVAAGSNFGLV----------GNGKLFILE---IDRSG 49 YH++ ++++P +N LAVA G N L+ NGK I + D G Sbjct: 248 YHIEC-----IEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFG 302 Query: 50 RIVEVNSFLTQDCLFD----------------LAWNESHENQVLVAQGDGTLRLFDTTFK 93 + + N + ++ D WN+ + Q+ + + + T Sbjct: 303 TVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQL-----EKDICI--TISC 355 Query: 94 EFPIAIFKEHEREVFSCNWNLVNRQ----------NFLSSSWDGSI-KIWSPLRKQSLMT 142 + + H + + + + S + S I Sbjct: 356 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 415 Query: 143 LTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLF 202 L ++ D I++KK + + + P NL+ S S + Sbjct: 416 LFVCSQRYVRIYDLSQQILVKK-----LLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWH 469 Query: 203 DIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIK 262 D+ L S L + + +F+K P + ++ D I ++ + + + Sbjct: 470 DLDLAST--PYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHATVYD-DMMKNPM 525 Query: 263 RTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRD 313 +L IN + + W P L SA D T R+W Sbjct: 526 IVPLKKLTGHKVINSL------GVLDAIWHPR-EAWLFSAGADNTARLWTT 569 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 31/79 (39%), Gaps = 2/79 (2%) Query: 203 DIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIK 262 D+R + + H G + T + +ATG D +R+W+I + T+ Sbjct: 183 DLRPFPIRCSTIYAGHKG-KVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLI 240 Query: 263 RTVPGQLHNSSCINEIPNA 281 ++ CI P+A Sbjct: 241 DDEENPDYHIECIEWNPDA 259 Score = 38.0 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 25/55 (45%), Gaps = 4/55 (7%) Query: 93 KEFPIAI---FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT 144 + FPI + H+ +V + + + + S DG++++W L + + T Sbjct: 185 RPFPIRCSTIYAGHKGKVRTLSIDPSGLW-LATGSDDGTVRVWEILTGREVYRTT 238 Score = 34.1 bits (76), Expect = 0.099, Method: Composition-based stats. Identities = 22/209 (10%), Positives = 52/209 (24%), Gaps = 19/209 (9%) Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 ++ S+ ++ R + I ++ P + + T + ++ V P Sbjct: 150 FERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDP 209 Query: 185 HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG---LEALTCDFNKYRPYVVATGGV 241 L + S + +++I + + ++N + V Sbjct: 210 SGLWL-ATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAV 268 Query: 242 DNAIRI-------WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 I + +DI K + S + N G Sbjct: 269 GENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDE--------D 320 Query: 295 HSNILMSASYDMTCRIWRDLSNDGAKETY 323 N + W S ++ Sbjct: 321 GENESAKNAVKKQVAQWNKPSQKQLEKDI 349 Score = 30.6 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 20/62 (32%), Gaps = 2/62 (3%) Query: 313 DLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 D ++ + + + H V G ++A+ + DG + VW Sbjct: 170 DPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSG--LWLATGSDDGTVRVWE 227 Query: 373 GL 374 L Sbjct: 228 IL 229 >6C0F-s nrPDB Length = 807 Score = 48.8 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 49/134 (36%), Gaps = 16/134 (11%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 + ++ + D + D P + HE+ V S N++ F S++ DG+I Sbjct: 690 PRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIH 748 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 190 ++ +M M+ PL + K + V A + P + L Sbjct: 749 VFHATVYDDMMKNP--------MIVPLKKLTGHKVINSL------GVLDAIWHPREAWLF 794 Query: 191 LSCSGNSYASLFDI 204 + + ++ A L+ Sbjct: 795 SAGA-DNTARLWTT 807 Score = 44.5 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 55/365 (15%), Positives = 105/365 (28%), Gaps = 80/365 (21%) Query: 76 VLVAQGDGTLRLFDTTFKEF--PIAIFKEHEREVF---SCNWNLVNRQNFLSSSWDGSI- 129 + DGT+R+++ + + E + WN L+ + +I Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 511 Query: 130 -----------------KIWSPLRKQSLMTLTPRPLEITKMVD----------------- 155 KI + T+ LE+ + D Sbjct: 512 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQ 571 Query: 156 -----PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK 210 + L+K IS + V + + V + S+ ++ Sbjct: 572 VAQWNKPSQKQLEKDICITISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHL 630 Query: 211 NQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI-------------------- 250 Q+ F G+ + F+ ++P + +RI+D+ Sbjct: 631 TQSPFKKSKGI-IMDAKFHPFKPQLFVC--SQRYVRIYDLSQQILVKKLLPGARWLSKID 687 Query: 251 ---RMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMT 307 R N S+ KR + L +S + H A+R V + + SA+ D T Sbjct: 688 IHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKK-LPLFSSAADDGT 746 Query: 308 CRI-WRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDG 366 + + +D K T + N V A W + ++ S D Sbjct: 747 IHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLG----VLDAIWHP--REAWLFSAGADN 800 Query: 367 NLFVW 371 +W Sbjct: 801 TARLW 805 Score = 41.0 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 58/351 (16%), Positives = 111/351 (31%), Gaps = 70/351 (19%) Query: 4 YHMQGFSGYGVQYSPFFDNR-LAVAAGSNFGLV----------GNGKLFILE---IDRSG 49 YH++ ++++P +N LAVA G N L+ NGK I + D G Sbjct: 486 YHIEC-----IEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFG 540 Query: 50 RIVEVNSFLTQDCLFD----------------LAWNESHENQVLVAQGDGTLRLFDTTFK 93 + + N + ++ D WN+ + Q+ + + + T Sbjct: 541 TVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQL-----EKDICI--TISC 593 Query: 94 EFPIAIFKEHEREVFSCNWNLVNRQ----------NFLSSSWDGSI-KIWSPLRKQSLMT 142 + + H + + + + S + S I Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 653 Query: 143 LTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLF 202 L ++ D I++KK + + + P NL+ S S + Sbjct: 654 LFVCSQRYVRIYDLSQQILVKK-----LLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWH 707 Query: 203 DIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIK 262 D+ L S L + + +F+K P + ++ D I ++ + + + Sbjct: 708 DLDLAST--PYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHATVYD-DMMKNPM 763 Query: 263 RTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRD 313 +L IN + + W P L SA D T R+W Sbjct: 764 IVPLKKLTGHKVINSL------GVLDAIWHPR-EAWLFSAGADNTARLWTT 807 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 31/79 (39%), Gaps = 2/79 (2%) Query: 203 DIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIK 262 D+R + + H G + T + +ATG D +R+W+I + T+ Sbjct: 421 DLRPFPIRCSTIYAGHKG-KVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLI 478 Query: 263 RTVPGQLHNSSCINEIPNA 281 ++ CI P+A Sbjct: 479 DDEENPDYHIECIEWNPDA 497 Score = 38.0 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 25/55 (45%), Gaps = 4/55 (7%) Query: 93 KEFPIAI---FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT 144 + FPI + H+ +V + + + + S DG++++W L + + T Sbjct: 423 RPFPIRCSTIYAGHKGKVRTLSIDPSGLW-LATGSDDGTVRVWEILTGREVYRTT 476 Score = 34.1 bits (76), Expect = 0.099, Method: Composition-based stats. Identities = 22/209 (10%), Positives = 52/209 (24%), Gaps = 19/209 (9%) Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 ++ S+ ++ R + I ++ P + + T + ++ V P Sbjct: 388 FERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDP 447 Query: 185 HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG---LEALTCDFNKYRPYVVATGGV 241 L + S + +++I + + ++N + V Sbjct: 448 SGLWL-ATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAV 506 Query: 242 DNAIRI-------WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 I + +DI K + S + N G Sbjct: 507 GENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDE--------D 558 Query: 295 HSNILMSASYDMTCRIWRDLSNDGAKETY 323 N + W S ++ Sbjct: 559 GENESAKNAVKKQVAQWNKPSQKQLEKDI 587 Score = 30.6 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 20/62 (32%), Gaps = 2/62 (3%) Query: 313 DLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 D ++ + + + H V G ++A+ + DG + VW Sbjct: 408 DPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSG--LWLATGSDDGTVRVWE 465 Query: 373 GL 374 L Sbjct: 466 IL 467 >6EM1-m nrPDB Length = 807 Score = 48.8 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 49/134 (36%), Gaps = 16/134 (11%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 + ++ + D + D P + HE+ V S N++ F S++ DG+I Sbjct: 690 PRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIH 748 Query: 131 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 190 ++ +M M+ PL + K + V A + P + L Sbjct: 749 VFHATVYDDMMKNP--------MIVPLKKLTGHKVINSL------GVLDAIWHPREAWLF 794 Query: 191 LSCSGNSYASLFDI 204 + + ++ A L+ Sbjct: 795 SAGA-DNTARLWTT 807 Score = 44.5 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 55/365 (15%), Positives = 105/365 (28%), Gaps = 80/365 (21%) Query: 76 VLVAQGDGTLRLFDTTFKEF--PIAIFKEHEREVF---SCNWNLVNRQNFLSSSWDGSI- 129 + DGT+R+++ + + E + WN L+ + +I Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 511 Query: 130 -----------------KIWSPLRKQSLMTLTPRPLEITKMVD----------------- 155 KI + T+ LE+ + D Sbjct: 512 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQ 571 Query: 156 -----PLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK 210 + L+K IS + V + + V + S+ ++ Sbjct: 572 VAQWNKPSQKQLEKDICITISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHL 630 Query: 211 NQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI-------------------- 250 Q+ F G+ + F+ ++P + +RI+D+ Sbjct: 631 TQSPFKKSKGI-IMDAKFHPFKPQLFVC--SQRYVRIYDLSQQILVKKLLPGARWLSKID 687 Query: 251 ---RMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMT 307 R N S+ KR + L +S + H A+R V + + SA+ D T Sbjct: 688 IHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKK-LPLFSSAADDGT 746 Query: 308 CRI-WRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDG 366 + + +D K T + N V A W + ++ S D Sbjct: 747 IHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLG----VLDAIWHP--REAWLFSAGADN 800 Query: 367 NLFVW 371 +W Sbjct: 801 TARLW 805 Score = 40.7 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 58/351 (16%), Positives = 111/351 (31%), Gaps = 70/351 (19%) Query: 4 YHMQGFSGYGVQYSPFFDNR-LAVAAGSNFGLV----------GNGKLFILE---IDRSG 49 YH++ ++++P +N LAVA G N L+ NGK I + D G Sbjct: 486 YHIEC-----IEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFG 540 Query: 50 RIVEVNSFLTQDCLFD----------------LAWNESHENQVLVAQGDGTLRLFDTTFK 93 + + N + ++ D WN+ + Q+ + + + T Sbjct: 541 TVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQL-----EKDICI--TISC 593 Query: 94 EFPIAIFKEHEREVFSCNWNLVNRQ----------NFLSSSWDGSI-KIWSPLRKQSLMT 142 + + H + + + + S + S I Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 653 Query: 143 LTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLF 202 L ++ D I++KK + + + P NL+ S S + Sbjct: 654 LFVCSQRYVRIYDLSQQILVKK-----LLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWH 707 Query: 203 DIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIK 262 D+ L S L + + +F+K P + ++ D I ++ + + + Sbjct: 708 DLDLAST--PYKTLRYHEKAVRSVNFHKKLP-LFSSAADDGTIHVFHATVYD-DMMKNPM 763 Query: 263 RTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRD 313 +L IN + + W P L SA D T R+W Sbjct: 764 IVPLKKLTGHKVINSL------GVLDAIWHPR-EAWLFSAGADNTARLWTT 807 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 31/79 (39%), Gaps = 2/79 (2%) Query: 203 DIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIK 262 D+R + + H G + T + +ATG D +R+W+I + T+ Sbjct: 421 DLRPFPIRCSTIYAGHKG-KVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLI 478 Query: 263 RTVPGQLHNSSCINEIPNA 281 ++ CI P+A Sbjct: 479 DDEENPDYHIECIEWNPDA 497 Score = 38.0 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 25/55 (45%), Gaps = 4/55 (7%) Query: 93 KEFPIAI---FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT 144 + FPI + H+ +V + + + + S DG++++W L + + T Sbjct: 423 RPFPIRCSTIYAGHKGKVRTLSIDPSGLW-LATGSDDGTVRVWEILTGREVYRTT 476 Score = 34.1 bits (76), Expect = 0.10, Method: Composition-based stats. Identities = 22/209 (10%), Positives = 52/209 (24%), Gaps = 19/209 (9%) Query: 125 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP 184 ++ S+ ++ R + I ++ P + + T + ++ V P Sbjct: 388 FERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDP 447 Query: 185 HDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSG---LEALTCDFNKYRPYVVATGGV 241 L + S + +++I + + ++N + V Sbjct: 448 SGLWL-ATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAV 506 Query: 242 DNAIRI-------WDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 I + +DI K + S + N G Sbjct: 507 GENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDE--------D 558 Query: 295 HSNILMSASYDMTCRIWRDLSNDGAKETY 323 N + W S ++ Sbjct: 559 GENESAKNAVKKQVAQWNKPSQKQLEKDI 587 Score = 30.6 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 20/62 (32%), Gaps = 2/62 (3%) Query: 313 DLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 D ++ + + + H V G ++A+ + DG + VW Sbjct: 408 DPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSG--LWLATGSDDGTVRVWE 465 Query: 373 GL 374 L Sbjct: 466 IL 467 >2I3T-A nrPDB Length = 341 Score = 48.4 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 50/305 (16%), Positives = 94/305 (30%), Gaps = 37/305 (12%) Query: 50 RIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDG--TLRLFDTTFKEFPIAIFKEHEREV 107 +IV++ +D + D+ S +L+ DG T+ FD K + ++ + Sbjct: 2 QIVQIEQ-APKDYISDIKIIPSKS-LLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPL 59 Query: 108 FSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT--------------PRPLEITKM 153 CN+ + G I + S LT I Sbjct: 60 LCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAAS 119 Query: 154 VDPLNAIILKKKSFTGI------SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLP 207 D L +I + G+ + N V F+ + L N+ + RLP Sbjct: 120 WDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQW-FRLP 178 Query: 208 SGKNQNNFLVHSGLE--ALTCDFNKYRPYVVATGGVDNAIRI--WDIRMLNKNESATIKR 263 ++ N + SGL+ A +D + + +D ++ + + Sbjct: 179 LCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFD----DQGDDYNSSK 234 Query: 264 TVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETY 323 + H + + + + +SP H L +A D W + K Sbjct: 235 RFAFRCHRLNLKDTNL---AYPVNSIEFSPRHK-FLYTAGSDGIISCWNLQTRKKIKNFA 290 Query: 324 KTNST 328 K N Sbjct: 291 KFNED 295 >6E29-D nrPDB Length = 345 Score = 47.6 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 34/291 (11%), Positives = 75/291 (25%), Gaps = 52/291 (17%) Query: 60 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQN 119 + + + + DGT+ ++D + H + + S +W+ + Sbjct: 24 RSGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGV-ARKLRGHSKNITSLSWSRC-GRY 81 Query: 120 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQ 179 LS+ + +W + + R + P N F + Sbjct: 82 LLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEP 141 Query: 180 AQFS------PHDQN----------------------LVLSCSGNSYASLFDIRLPSGKN 211 + P + +V + SG+ + K Sbjct: 142 VEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLL------AGTTKG 195 Query: 212 QNNFLVHSGLE----------ALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATI 261 + N + E +T + D IR + + L+ + Sbjct: 196 RLNIIDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPD 255 Query: 262 KRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWR 312 +P + +N + H V +S + S + IW Sbjct: 256 TIQLPLEHKFQDVVNRLSWNH------VAFSATGEYVAASTYNNHELYIWE 300 Score = 43.4 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 26/154 (16%), Positives = 43/154 (27%), Gaps = 39/154 (25%) Query: 217 VHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCIN 276 + FN + +A+G VD + IWD+ + Sbjct: 22 TIRSGHSTCVRFN-RKGDFLASGRVDGTVVIWDLETMGVA-------------------- 60 Query: 277 EIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIF 336 H I ++WS L+SA +W D + Sbjct: 61 RKLRGHSKNITSLSWS-RCGRYLLSACQGWKVILWDL--------------QDGKRYREV 105 Query: 337 NFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFV 370 F V+GA+ W + A+ D + V Sbjct: 106 RFR---APVYGAELHPWNHHQFAAALFEDQPMLV 136 >5A9Q-2 nrPDB Length = 326 Score = 45.7 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 44/303 (14%), Positives = 84/303 (27%), Gaps = 64/303 (21%) Query: 14 VQYSPFFDN---RLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDC-LFDLAWN 69 V+++PF + L G+N+ ++G E D G + + +AW+ Sbjct: 22 VEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAWS 81 Query: 70 E-------SHENQVLVAQGDGTLRLFDTTFKE-FPIAIFKEHEREVFSCNWNLVNRQNFL 121 + + D +RLF + ++ + + H + ++ Q Sbjct: 82 PETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIA 141 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQ 181 S S D + +IW L + P ++ Sbjct: 142 SVSDDHTCRIW---------NLEGVQTAHFVLHSPGMSV--------------------C 172 Query: 182 FSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGV 241 + P + ++ N +D+ Q + S L + Sbjct: 173 WHPEETFKLMVAEKNGTIRFYDL----LAQQAILSLESEQVPLMSAHWCLKNTFKVGAVA 228 Query: 242 DNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMS 301 N IWDI ++ KR V H WS N+ + Sbjct: 229 GNDWLIWDI---TRSSYPQNKRPV----------------HMDRACLFRWSTISENLFAT 269 Query: 302 ASY 304 Y Sbjct: 270 TGY 272 Score = 45.3 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 24/164 (14%), Positives = 44/164 (26%), Gaps = 26/164 (15%) Query: 190 VLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWD 249 + + + LF L H+ F+ +A+ D+ RIW+ Sbjct: 95 FCTSAADMKIRLFTSDLQDKNEYKVLEGHTDF-INGLVFDPKEGQEIASVSDDHTCRIWN 153 Query: 250 IRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCR 309 + + H + V W P + LM A + T R Sbjct: 154 LEGVQTAHFVL---------------------HSPGMS-VCWHPEETFKLMVAEKNGTIR 191 Query: 310 IWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLW 353 + L+ S S +++ V + W Sbjct: 192 FYDLLAQQA---ILSLESEQVPLMSAHWCLKNTFKVGAVAGNDW 232 Score = 36.8 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 38/102 (37%), Gaps = 22/102 (21%) Query: 281 AHGLAIRKVTWSPHHSN-------ILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKG 333 HG+ + + WSP +++ DM R++ S+ K YK Sbjct: 70 HHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFT--SDLQDKNEYK--------- 118 Query: 334 SIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG 375 H++F+ G + + +AS + D +WN G Sbjct: 119 ---VLEGHTDFINGLVFDPK-EGQEIASVSDDHTCRIWNLEG 156 >6BX3-B nrPDB Length = 412 Score = 45.7 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 53/349 (15%), Positives = 108/349 (30%), Gaps = 76/349 (21%) Query: 64 FDLAWNESHENQVLVAQGDGTLRLFDT-TFKE--FPIAIFKEHEREVFSCNWNLVNRQNF 120 + + + + +G L ++D TF+ P + H R + S W+ + Sbjct: 28 TECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD-GRLL 86 Query: 121 LSSSWDGSIKIW------------------------SPLRKQSLMTLTPRP--LEITKMV 154 L+SS D SIK+W R+ + T+ I Sbjct: 87 LTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSN 146 Query: 155 DPLNAIILKKKSFTGISK-NRNCVYQAQFSPHDQNLVLSCSGNSYASLFDI-RLPSGKNQ 212 DP+ +++ K S + V N+++ + + + L + Sbjct: 147 DPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECI 206 Query: 213 NNFL-VHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHN 271 ++ S ++ L +A D IR ++I N Sbjct: 207 HSLKITSSNIKHLIV---SQNGERLAINCSDRTIRQYEI---------------SIDDEN 248 Query: 272 SSCINEIPNAHGLAIRKVTW-----SPHHSNILMSA---SYDMTCRIWRDLSNDGAKETY 323 S+ + + + I K+ W S + + L+++ S IW S Sbjct: 249 SAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSG------- 301 Query: 324 KTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + E + +W + V++ GN++VW+ Sbjct: 302 ---------TLVRVLEGAEEELIDINWDFYS-MSIVSNGFESGNVYVWS 340 Score = 44.5 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 39/114 (34%), Gaps = 18/114 (15%) Query: 214 NFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSS 273 + + L F+ Y +A G + A+ I+D+ Sbjct: 19 THTIENPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVP-------------- 63 Query: 274 CINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNS 327 + AH I + WSP +L+++S D + ++W + + +S Sbjct: 64 --GNMLGAHVRPITSIAWSP-DGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDS 114 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 28/122 (22%), Positives = 51/122 (41%), Gaps = 10/122 (8%) Query: 43 LEIDRSGRIVEVN-SFLTQDCLFDLAWN----ESHENQVLVAQGDGT----LRLFDTTFK 93 + ID VE+ QD + L WN ++ + LVA G+ L +++TT Sbjct: 242 ISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSG 301 Query: 94 EFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM 153 + + + E E+ NW+ + + G++ +WS + L P E+ + Sbjct: 302 TL-VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEEN 360 Query: 154 VD 155 VD Sbjct: 361 VD 362 >3JB9-S nrPDB Length = 488 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 19/126 (15%), Positives = 45/126 (35%), Gaps = 7/126 (5%) Query: 37 NGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFP 96 N K +I + + V +T + N + +G LR F+T+ Sbjct: 315 NEKCYIFSLKSQVYNITVAQHITSLAVH------PDGNLFVAGLENGELRFFETSSG-NE 367 Query: 97 IAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDP 156 + F H V + + ++++ D I IW + + + + + +D Sbjct: 368 LTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAVSLDI 427 Query: 157 LNAIIL 162 + +++ Sbjct: 428 TSQLLV 433 Score = 39.5 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 37/273 (13%), Positives = 83/273 (30%), Gaps = 59/273 (21%) Query: 40 LFILEIDRSG--RIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPI 97 +F + SG + E S + D + +L A + +F + + I Sbjct: 272 IFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEK-CYIFSLKSQVYNI 330 Query: 98 AIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPL 157 +H + S + F++ +G ++ + L P Sbjct: 331 -TVAQH---ITSLAVHPD-GNLFVAGLENGELRFFETSSGNELTKFGPHS---------- 375 Query: 158 NAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLV 217 + V QF + LV++ + +S ++D+R + + Sbjct: 376 -----------------SPVKTLQFGENGYWLVVTTNDDSDIFIWDLR--KSELVQKIPL 416 Query: 218 HSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINE 277 + + A++ D +V++ G + I+ + +S Sbjct: 417 QTKVAAVSLDI--TSQLLVSSDGETLYVHIY--------------------VKSSKSWRC 454 Query: 278 IPNAHGLAIRKVTWSPHHSNILMSASYDMTCRI 310 + H +I + W +L S S R+ Sbjct: 455 MSQTHVSSISNLVWLNELHQLLFSTSNGAILRL 487 Score = 31.0 bits (68), Expect = 0.77, Method: Composition-based stats. Identities = 31/235 (13%), Positives = 67/235 (28%), Gaps = 32/235 (13%) Query: 149 EITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSP---HDQNLVLSCSGNSYASLFDIR 205 +++++ + IL+ + + F D+ L L NS +F+ Sbjct: 191 AVSQLLQATPSTILENLETESTTSFFPSPENSSFVLCLHKDELLCLDIQSNSTLKIFEGS 250 Query: 206 LPSGKNQNNFLVH-SGLEALTCDFNKYRPYVVATGGV-------DNAIRIWDIRMLNKNE 257 + + + + +A++ + + G D + + Sbjct: 251 ALACCWLTSSKIAVATADAISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYL 310 Query: 258 SATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND 317 A S N H I + P N+ ++ + R + S Sbjct: 311 LAASNEKCYIFSLKSQVYNITVAQH---ITSLAVHP-DGNLFVAGLENGELRFFETSSG- 365 Query: 318 GAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 + F HS V + G V +T D ++F+W+ Sbjct: 366 ---------------NELTKFGPHSSPVKTLQFGENGY-WLVVTTNDDSDIFIWD 404 >5WLC-LN nrPDB Length = 776 Score = 43.0 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 48/338 (14%), Positives = 102/338 (30%), Gaps = 64/338 (18%) Query: 37 NGKLFILEIDRSGRIVEVNSFLTQDC--LFDLAWNESHENQVLVAQGDGTLRLFDTTFKE 94 NG + +++I ++E ++ L + + LAW + ++ V+ DG +R++ + Sbjct: 162 NGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKK--DDFVIGGCSDGRIRIWSAQKND 219 Query: 95 FPIAIFKEHEREVFS-----CNWN---LVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPR 146 + + + W+ L S GSIK W + Sbjct: 220 ENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAH 279 Query: 147 PLEITKM-VDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIR 205 ++ + D N + I + ++Q + Sbjct: 280 DADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQ-----------------------K 316 Query: 206 LPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTV 265 N +N L+H C + + +GGV+ + I + + + Sbjct: 317 NNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVE 376 Query: 266 PGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKT 325 P N + N + V+WS + T +IW ++ ++ YK Sbjct: 377 PYS------KNVLVNKEQRLV--VSWS------------ESTVKIWTMGTDSSTEQNYKL 416 Query: 326 NSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTA 363 K + + S G+ V + Sbjct: 417 VCKLTLKDD--------QNISTCSLSPDGQVLVVGRPS 446 Score = 32.2 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 36/235 (15%), Positives = 75/235 (31%), Gaps = 30/235 (12%) Query: 147 PLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASL----- 201 ++ + + ++ ++ K S+ R V++ +F + S + + +++ Sbjct: 3 SSLLSVLKEKSRSLKIRNKPVKMTSQERMIVHRCRFVDFTPATITSLAFSHKSNINKLTP 62 Query: 202 FDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATI 261 D+RL G++ N + + N + +V GG D +I +N Sbjct: 63 SDLRLAIGRSNGNIEIWNPR-------NNWFQEMVIEGGKDRSIEGLCWSNVNGESLRLF 115 Query: 262 KRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKE 321 + +P + V WS I ++ S D LS Sbjct: 116 SIGGSTVVTEWDLATGLPLRNYDCNSGVIWS-----ISINDSQDK-------LSVGCDNG 163 Query: 322 TYKTNSTDATKGSIFNFT---QHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 373 T G + + T + V W +V DG + +W+ Sbjct: 164 TVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDD---FVIGGCSDGRIRIWSA 215 >5WLC-LW nrPDB Length = 554 Score = 39.9 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 36/199 (18%), Positives = 63/199 (31%), Gaps = 39/199 (19%) Query: 57 FLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVN 116 FL + C A +E VAQ T ++D + + K+H E ++ L Sbjct: 149 FLNETCHS--ATYLQNEQYFAVAQKKYTF-IYD--HEGTELHRLKQHI-EARHLDF-LPY 201 Query: 117 RQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNC 176 +++ G +K Q + L + P A+ + + N Sbjct: 202 HYLLVTAGETGWLKYHDVSTGQLVSELRTKA-------GPTMAMAQNPWNAVMHLGHSN- 253 Query: 177 VYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVV 236 SL+ PS L+ + + Y + Sbjct: 254 --------------------GTVSLW---SPSMPEPLVKLLSARGPVNSIAI-DRSGYYM 289 Query: 237 ATGGVDNAIRIWDIRMLNK 255 AT G D +++IWDIR + Sbjct: 290 ATTGADRSMKIWDIRNFKQ 308 >5WLC-SG nrPDB Length = 573 Score = 39.5 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 43/315 (13%), Positives = 81/315 (25%), Gaps = 70/315 (22%) Query: 91 TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEI 150 T K + H E+ + + + ++ D + +WS Sbjct: 223 TSKHEYENTTEGHYDEILTVA-ASPDGKYVVTGGRDRKLIVWS----------------- 264 Query: 151 TKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK 210 T+ + P+ I K + V F + L SC+ F IR S Sbjct: 265 TESLSPVKVIPTKDRRGE--------VLSLAFRKNSDQLYASCAD------FKIRTYSIN 310 Query: 211 NQNNFLVHSGLEALTCDFNKYR-PYVVATGGVDNAIRIWD------------------IR 251 + + G + D + V G D +W +R Sbjct: 311 QFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLR 370 Query: 252 MLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 K + + S + V ++ S + +W Sbjct: 371 RWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMV-----DDFHFITGSDNGNICLW 425 Query: 312 RDLSN-------DGAKETYKTNSTDATKGSIFNFTQH---SEFVFGADW--SLWGKPG-- 357 + + D + + + + + W SL+ P Sbjct: 426 SLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSN 485 Query: 358 YVASTAWDGNLFVWN 372 S +W G+L VW Sbjct: 486 VFISGSWSGSLKVWK 500 Score = 33.7 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 21/130 (16%), Positives = 51/130 (39%), Gaps = 11/130 (8%) Query: 82 DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWS-PLRKQSL 140 DG ++ D + E P+ + V ++V+ +F++ S +G+I +WS +K Sbjct: 382 DGEVKYPDES--EAPLFFCEGSIDVV-----SMVDDFHFITGSDNGNICLWSLAKKKPIF 434 Query: 141 MTLTPRPLEITKMVDPLNAII---LKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNS 197 + + ++ L+K+ G + + ++ N+ +S S + Sbjct: 435 TERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSG 494 Query: 198 YASLFDIRLP 207 ++ I Sbjct: 495 SLKVWKISDN 504 >4J0X-A nrPDB Length = 451 Score = 39.5 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 43/315 (13%), Positives = 81/315 (25%), Gaps = 70/315 (22%) Query: 91 TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEI 150 T K + H E+ + + + ++ D + +WS Sbjct: 101 TSKHEYENTTEGHYDEILTVA-ASPDGKYVVTGGRDRKLIVWS----------------- 142 Query: 151 TKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK 210 T+ + P+ I K + V F + L SC+ F IR S Sbjct: 143 TESLSPVKVIPTKDRRGE--------VLSLAFRKNSDQLYASCAD------FKIRTYSIN 188 Query: 211 NQNNFLVHSGLEALTCDFNKYR-PYVVATGGVDNAIRIWD------------------IR 251 + + G + D + V G D +W +R Sbjct: 189 QFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLR 248 Query: 252 MLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIW 311 K + + S + V ++ S + +W Sbjct: 249 RWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMV-----DDFHFITGSDNGNICLW 303 Query: 312 RDLSN-------DGAKETYKTNSTDATKGSIFNFTQH---SEFVFGADW--SLWGKPG-- 357 + + D + + + + + W SL+ P Sbjct: 304 SLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSN 363 Query: 358 YVASTAWDGNLFVWN 372 S +W G+L VW Sbjct: 364 VFISGSWSGSLKVWK 378 Score = 33.7 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 21/130 (16%), Positives = 51/130 (39%), Gaps = 11/130 (8%) Query: 82 DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWS-PLRKQSL 140 DG ++ D + E P+ + V ++V+ +F++ S +G+I +WS +K Sbjct: 260 DGEVKYPDES--EAPLFFCEGSIDVV-----SMVDDFHFITGSDNGNICLWSLAKKKPIF 312 Query: 141 MTLTPRPLEITKMVDPLNAII---LKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNS 197 + + ++ L+K+ G + + ++ N+ +S S + Sbjct: 313 TERIAHGILPEPSFNDISGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSG 372 Query: 198 YASLFDIRLP 207 ++ I Sbjct: 373 SLKVWKISDN 382 >5MC6-j nrPDB Length = 397 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 29/138 (21%), Positives = 59/138 (42%), Gaps = 17/138 (12%) Query: 235 VVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPH 294 ++ATG + ++I ++ L L+N + + N + +IR V +SP Sbjct: 199 LIATGFNNGTVQISELSTLR-------------PLYNFESQHSMIN-NSNSIRSVKFSPQ 244 Query: 295 HSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG 354 S + ++ + I + G + + T +++ S+ F HS +V ++ G Sbjct: 245 GSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFA-HSSWVMSLSFNDSG 303 Query: 355 KPGYVASTAWDGNLFVWN 372 + + S WDG L W+ Sbjct: 304 ET--LCSAGWDGKLRFWD 319 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 33/147 (22%), Positives = 51/147 (34%), Gaps = 16/147 (10%) Query: 23 RLAVAAGSNFGLVGNGKLFILE-----------IDRSGRIVEVNSFLTQDCLFDLAWNES 71 R +A G N G V +L L I+ S I V F Q L +A + + Sbjct: 197 RGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSV-KFSPQGSLLAIAHDSN 255 Query: 72 HENQVL---VAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGS 128 + G+ L T H V S ++N + + S+ WDG Sbjct: 256 SFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFN-DSGETLCSAGWDGK 314 Query: 129 IKIWSPLRKQSLMTLTPRPLEITKMVD 155 ++ W K+ + TL +I D Sbjct: 315 LRFWDVKTKERITTLNMHCDDIEIEED 341 Score = 34.5 bits (77), Expect = 0.077, Method: Composition-based stats. Identities = 22/208 (10%), Positives = 58/208 (27%), Gaps = 27/208 (12%) Query: 64 FDLAWNESHENQVLVAQGDGTLRLF----------DTTFKEFPIAIFKE-----HEREVF 108 + + + ++++ GT ++ T P + F Sbjct: 129 WGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQF 188 Query: 109 SCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT 168 + + ++ R + +G+++I + L + I + + S Sbjct: 189 ATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLL 248 Query: 169 GISKNRNCVYQAQFSPHD-QNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCD 227 I+ + N + + S S + ++ Sbjct: 249 AIAHDSNSFGCITLYETEFGERIGSLSV----------PTHSSQASLGEFAHSSWVMSLS 298 Query: 228 FNKYRPYVVATGGVDNAIRIWDIRMLNK 255 FN + + G D +R WD++ + Sbjct: 299 FND-SGETLCSAGWDGKLRFWDVKTKER 325 Score = 29.5 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 28/196 (14%), Positives = 66/196 (33%), Gaps = 24/196 (12%) Query: 188 NLVLSCSGNSYASLFDIR-----LPSGKNQNNFLVHSGLEAL----TCDFNKYRPYVVAT 238 + +SCSG+ Y ++D + P K+ ++F+ SGL + + + + +VAT Sbjct: 27 SFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDVLQAIERDAFELCLVAT 86 Query: 239 GGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNI 298 + + I ++ + ++ ++ H + W + + Sbjct: 87 TSFSGDLLFYRITREDETKKVIFEKL--------DLLDSDMKKHSFW--ALKWGASNDRL 136 Query: 299 ----LMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWG 354 L++ T IW+ + T + T A Sbjct: 137 LSHRLVATDVKGTTYIWK-FHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDIS 195 Query: 355 KPGYVASTAWDGNLFV 370 + G +A+ +G + + Sbjct: 196 ERGLIATGFNNGTVQI 211 >5CXB-B nrPDB Length = 369 Score = 38.7 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 23/129 (17%), Positives = 41/129 (31%), Gaps = 11/129 (8%) Query: 183 SPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVD 242 P NLV+ S + D+ L + F+K + A D Sbjct: 251 HPGGDNLVV-GSYDKRLLWHDLDL--SNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDD 307 Query: 243 NAIRIWDIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSA 302 +++I+ ++ N V + + L + + W P +SA Sbjct: 308 GSLQIFHGKVPNDQLENPTIVPV-------KMLKGHKVVNKLGVLDIDWHPR-EPWCVSA 359 Query: 303 SYDMTCRIW 311 D T R+W Sbjct: 360 GADGTARLW 368 Score = 37.2 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 24/55 (43%), Gaps = 4/55 (7%) Query: 93 KEFPIA---IFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLT 144 K FP IF+ HE V S + + DG++++W L + + ++ Sbjct: 7 KPFPTVQQTIFRGHEGRVRSVAIDPT-GVALATGGDDGTVRVWELLTGRQVWSVK 60 Score = 36.8 bits (83), Expect = 0.015, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 30/86 (34%), Gaps = 11/86 (12%) Query: 173 NRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSG----------KNQNNFLVHSGLE 222 + + +F L S + +F ++P+ K V + L Sbjct: 284 HTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLG 343 Query: 223 ALTCDFNKYRPYVVATGGVDNAIRIW 248 L D++ P+ V + G D R+W Sbjct: 344 VLDIDWHPREPWCV-SAGADGTARLW 368 Score = 33.3 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 15/42 (35%), Gaps = 1/42 (2%) Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSN 316 I H +R V P L + D T R+W L+ Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVA-LATGGDDGTVRVWELLTG 53 Score = 30.3 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 34/93 (36%), Gaps = 21/93 (22%) Query: 211 NQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLH 270 Q F H G + + +ATGG D +R+W++ T ++ +L+ Sbjct: 13 QQTIFRGHEG-RVRSVAIDP-TGVALATGGDDGTVRVWEL--------LTGRQVWSVKLN 62 Query: 271 NSSCINEIPNAHGLAIRKVTWSPHHSNILMSAS 303 +N V W P +++A+ Sbjct: 63 GDEAVNT-----------VRWRPTKDTFILAAA 84 >4FHN-A nrPDB Length = 394 Score = 38.4 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 36/237 (15%), Positives = 69/237 (29%), Gaps = 34/237 (14%) Query: 108 FSCNW--NLVNRQNFLSSSWDGSIKIW--SPLRKQSLMTLTPRPLEITKMVDPLNAIILK 163 ++ W + N L+ D I I+ S + LT + L + P + Sbjct: 20 YTTTWCSQSPSCSNLLAIGHDTGITIYCASEEQTPGSTGLTLQELFTIQTGLPTLHLSFS 79 Query: 164 KKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEA 223 + + + SP + ++ L + + Q+ SG Sbjct: 80 SSCSYSENLH-DGDGNVNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHN 138 Query: 224 LTCDF---------NKYRPYVVATGGVDNAIRIWDIRMLNKNESATIKRTVPGQLHNSSC 274 D N+ V+A+ G D + IW R+ ++ + Sbjct: 139 FVNDIDIADVYSADNRLAEQVIASVGDDCTLIIW--RLTDEGPILAGYPLSSPGI----- 191 Query: 275 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDAT 331 V + P + N L+ + RI+ N A+E +T Sbjct: 192 -------------SVQFRPSNPNQLIVGERNGNIRIFDWTLNLSAEENSQTELVKNP 235 >5YZG-2 nrPDB Length = 646 Score = 36.8 bits (83), Expect = 0.015, Method: Composition-based stats. Identities = 31/234 (13%), Positives = 68/234 (29%), Gaps = 31/234 (13%) Query: 140 LMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYA 199 + ++ K ++ + +S + + S L S + Sbjct: 105 ITASHDGHVKFWKKIEEGIEFVKHFRS------HLGVIESIAVSSEG-ALFCSVGDDKAM 157 Query: 200 SLFDIRLPSGKNQNNFLVHSGL-EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNES 258 +FD+ N G E + C + V A+ I I+D R N+ Sbjct: 158 KVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISS-VAASEKSTGKIFIYDGRGDNQP-- 214 Query: 259 ATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDG 318 ++ H + ++ +P + + +S+ W Sbjct: 215 ----------------LHIFDKLHTSPLTQIRLNPVYKAV-VSSDKSGMIEYW-TGPPHE 256 Query: 319 AKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 K N T ++ F + + +S GK +A+ D + ++ Sbjct: 257 YKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKK--IATIGSDRKVRIFR 308 >6CHG-D nrPDB Length = 439 Score = 36.8 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 11/105 (10%) Query: 60 QDCLFDLAWN----ESHENQVLVAQGDGT----LRLFDTTFKEFPIAIFKEHEREVFSCN 111 QD + L WN +H + LVA G+ L L++T+ + + + + E+ + Sbjct: 269 QDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSL-VRVLEGADEELLDID 327 Query: 112 WNLVNRQNFLSSSWD-GSIKIWSPLRKQSLMTLTPRPLEITKMVD 155 WN S+ ++ G + +WS + L P E+ + +D Sbjct: 328 WNF-YSMRIASNGFESGWVYMWSIVIPPKWSALAPDFEEVEENID 371 >6N8P-A nrPDB Length = 979 Score = 36.4 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 58/374 (15%), Positives = 109/374 (29%), Gaps = 66/374 (17%) Query: 37 NGKLFILEI-------DRSGRIVEVNSFLTQDCLFDLAW--------NESHENQVLVAQG 81 +G +F++++ DR+ V L ++ + + NQ+L+ Sbjct: 139 SGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYS 198 Query: 82 DGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLM 141 G + ++D + E W + + +S DGS W S Sbjct: 199 RGLVVIWDLQGSRVLYHFLSSQQLENI---WWQRDGRLLVSCHSDGSYCQWPV----SSE 251 Query: 142 TLTPRPLEITKMVDPLNAIILKK------KSFTGISKNRNCVYQAQFSPHDQNLVLSCSG 195 P PL P + + + + + + +A + +S Sbjct: 252 AQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRH---CISVIH 308 Query: 196 NSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGG---VDNAIRIW-DIR 251 + + FD F V + + + Y V+A +D W ++ Sbjct: 309 DGQQTAFDF----TSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQ 364 Query: 252 MLNKNESATIKRTVPGQLHNSS--------CINEIPNAH-------GLAIRKVTWSPHHS 296 + T + N NAH +T +P Sbjct: 365 LPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQR 424 Query: 297 NILMSASYDMTCRIWRDLSNDGAKETYKTNS-----TDATKGSIFNFTQHSEFVFGADWS 351 ++L++ D T R W D S + YK ++ TD F+ E W Sbjct: 425 DLLLTGHEDGTVRFW-DASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDE------WP 477 Query: 352 LWGKPGYVASTAWD 365 K G + D Sbjct: 478 PLRKVGSFDPYSDD 491 >6AJD-A nrPDB Length = 485 Score = 34.5 bits (77), Expect = 0.079, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 57/163 (34%), Gaps = 7/163 (4%) Query: 132 WSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 191 W+ +M+ RP+E + + + T C Q D + + Sbjct: 280 WATAAGY-VMSPPFRPVEHQEALWRGLQSGNLHTTATDHCCF--CAEQKAMGRDDFSKIP 336 Query: 192 SCS---GNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 248 + + + A L+D + SG+ + V FN + G D + +W Sbjct: 337 NGTAGIEDRMALLWDAGVNSGRLSMHEFVALTSTNTAKIFNLFPRKGAIRVGADADLVLW 396 Query: 249 DIRMLNKNESATIKRTVPGQLHNSSCINEIPNAHGLAIRKVTW 291 D + +AT + V + + IP +H ++ K+ W Sbjct: 397 DPQGSRTLSAATHHQRVDFNIFEGRTVRGIP-SHTISQGKLLW 438 >6CVZ-A nrPDB Length = 351 Score = 33.7 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 20/91 (21%), Positives = 38/91 (41%), Gaps = 18/91 (19%) Query: 282 HGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQH 341 HG IR + +S + +L+SAS D T ++ L + +TY Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKL-TSLETNTVVQTYNA---------------- 115 Query: 342 SEFVFGADWSLWGKPGYVASTAWDGNLFVWN 372 V+ W L + Y+ + +G++ V++ Sbjct: 116 GRPVWSCCWCLD-EANYIYAGLANGSILVYD 145 Score = 28.3 bits (61), Expect = 5.7, Method: Composition-based stats. Identities = 25/205 (12%), Positives = 47/205 (22%), Gaps = 32/205 (15%) Query: 63 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHERE--VFSCNWNL------ 114 ++ W N + +G++ ++D + + + S ++ Sbjct: 119 VWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAA 178 Query: 115 -VNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKN 173 + D S W S V PL S++ Sbjct: 179 FPYGGVLAGTLEDAS--FWEQKMDFSH----------WPHVLPLEPGGCIDFQTENSSRH 226 Query: 174 RNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFN---- 229 Y+ + + S L D P Q G N Sbjct: 227 CLVTYRPD---KNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQ 283 Query: 230 -KYRPYVVATGGVD---NAIRIWDI 250 + D N+ +WD Sbjct: 284 SPENDGNILVCTGDEAANSALLWDA 308 >5AMS-A nrPDB Length = 431 Score = 31.8 bits (70), Expect = 0.45, Method: Composition-based stats. Identities = 18/116 (15%), Positives = 42/116 (36%), Gaps = 10/116 (8%) Query: 69 NESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKE---HEREVFSCNWNLVNRQN----FL 121 + + DG++ + ++ + H+++ + ++ + Sbjct: 163 HPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELV 222 Query: 122 SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT-GISKNRNC 176 + S D +I W+ Q L +T EI + P ++ L ++ T G S C Sbjct: 223 TCSLDSTIVAWNCFTGQQLFKIT--QAEIKGLEAPWISLSLAPETLTKGNSGVVAC 276 >2P9P-C nrPDB Length = 372 Score = 31.0 bits (68), Expect = 0.75, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 31/89 (34%), Gaps = 5/89 (5%) Query: 46 DRSG-RIVEVNSFLTQDC-LFDLAWNESHENQVLVAQGDGTLRLFDTTFKE-FPIAIFKE 102 ++SG + V+V+ + + + W N+++ D ++ + P + Sbjct: 36 EKSGNKWVQVHELKEHNGQVTGVDWAP-DSNRIVTCGTDRNAYVWTLKGRTWKPTLVILR 94 Query: 103 HEREVFSCNWNLVNRQNFLSSSWDGSIKI 131 R W N + F S I I Sbjct: 95 INRAARCVRW-APNEKKFAVGSGSRVISI 122 >5WLC-LH nrPDB Length = 896 Score = 30.6 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 12/62 (19%), Positives = 25/62 (40%), Gaps = 3/62 (4%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 130 + Q+ V G + + + + I + K H V S +++ LS W+ + Sbjct: 266 NMGQQLAVGFASGVISI--VSLADLQIRLLKWHIDSVLSLSFSHD-GSYLLSGGWEKVMS 322 Query: 131 IW 132 +W Sbjct: 323 LW 324 >3C75-L nrPDB Length = 188 Score = 30.6 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 35/108 (32%), Gaps = 14/108 (12%) Query: 34 LVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFK 93 L G + +L +DR GR+ N+ + + A + +N + + D Sbjct: 35 LAGAALVPLLPVDRRGRVSRANAAGPAEGVDPRAKWQPQDNDIQACDYWRHCSI-DGNIC 93 Query: 94 EFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLM 141 + N ++SW S ++P QS + Sbjct: 94 DCSGGSLT-----------NCPPGTKLATASWVASC--YNPTDGQSYL 128 >4V0N-B nrPDB Length = 425 Score = 30.6 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 15/64 (23%), Positives = 26/64 (40%), Gaps = 1/64 (1%) Query: 87 LFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPR 146 ++ F + P+A + V +CN + + D +KIW +K S L Sbjct: 39 VWLDAFND-PVAGISAYTPCVHTCNLFGDGENRLVIADEDRKLKIWKGTQKASEHPLLDT 97 Query: 147 PLEI 150 P+ I Sbjct: 98 PVAI 101 >2VR2-A nrPDB Length = 541 Score = 30.3 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 31/89 (34%) Query: 191 LSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI 250 ++ + + +++ + SGK N V FN Y G D I IWD Sbjct: 371 VNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDP 430 Query: 251 RMLNKNESATIKRTVPGQLHNSSCINEIP 279 + + T + V + + +P Sbjct: 431 KGTRTISAKTHHQAVNFNIFEGMVCHGVP 459 >5OVO-B nrPDB Length = 99 Score = 30.3 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 20/27 (74%) Query: 25 AVAAGSNFGLVGNGKLFILEIDRSGRI 51 A+ +N G +G+GK+F+L+I ++ RI Sbjct: 63 AIQKAANTGRIGDGKIFVLDIAQAVRI 89 >4CO4-A nrPDB Length = 112 Score = 30.3 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 20/27 (74%) Query: 25 AVAAGSNFGLVGNGKLFILEIDRSGRI 51 A+ +N G +G+GK+F+L+I ++ RI Sbjct: 76 AIQKAANTGRIGDGKIFVLDIAQAVRI 102 >4PDX-A nrPDB Length = 640 Score = 28.0 bits (60), Expect = 7.4, Method: Composition-based stats. Identities = 12/56 (21%), Positives = 24/56 (42%), Gaps = 3/56 (5%) Query: 32 FGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNESHENQVLVAQ-GDGTLR 86 +G V GK ++ + S R++ + + + W+ QV+ A GD + Sbjct: 415 YGQVEMGKRYVQALGGSARVINLAQEANKQGDYR--WSAELLKQVIAANPGDQVAK 468 >5JVV-B nrPDB Length = 298 Score = 28.0 bits (60), Expect = 7.5, Method: Composition-based stats. Identities = 13/91 (14%), Positives = 29/91 (31%), Gaps = 8/91 (8%) Query: 71 SHENQVLVAQGDGTLRLFDTTFKEF-----PIAIFKEHEREVFSCNWNLVNRQNFLSSSW 125 + N + + D T TT + P + + ++N + Sbjct: 135 TKGNCEITSDDDQTGT---TTSNQCSLDAGPAGCVVQGTPGSYGSSFNEQGGGVYAMQWT 191 Query: 126 DGSIKIWSPLRKQSLMTLTPRPLEITKMVDP 156 D IK+W R ++ ++++ P Sbjct: 192 DEFIKLWFFPRSAIPKSIESDSPDVSEFGTP 222 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.114 0.293 Lambda K H 0.267 0.0348 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,802,500 Number of Sequences: 36641 Number of extensions: 455078 Number of successful extensions: 3642 Number of sequences better than 10.0: 141 Number of HSP's better than 10.0 without gapping: 148 Number of HSP's successfully gapped in prelim test: 90 Number of HSP's that attempted gapping in prelim test: 1329 Number of HSP's gapped (non-prelim): 852 length of query: 375 length of database: 10,336,785 effective HSP length: 99 effective length of query: 276 effective length of database: 6,709,326 effective search space: 1851773976 effective search space used: 1851773976 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 59 (27.6 bits)