BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P39079 (546 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5GW5-z nrPDB 1115 0.0 4B2T-Z nrPDB 615 e-176 3J1E-A nrPDB 297 1e-80 4XCG-B nrPDB 284 5e-77 3J1C-A nrPDB 273 1e-73 1A6E-A nrPDB 273 2e-73 1Q3S-A nrPDB 267 9e-72 4XCI-A nrPDB 260 1e-69 1A6D-B nrPDB 251 7e-67 3RUW-A nrPDB 247 8e-66 3IYF-A nrPDB 241 8e-64 4B2T-G nrPDB 233 2e-61 3AQ1-B nrPDB 231 8e-61 4B2T-H nrPDB 212 3e-55 5GW5-g nrPDB 202 2e-52 5UYZ-A nrPDB 201 5e-52 4B2T-A nrPDB 199 3e-51 4V8R-AE nrPDB 197 8e-51 4B2T-D nrPDB 193 1e-49 4V94-A nrPDB 190 2e-48 5GW4-h nrPDB 189 2e-48 5GW4-d nrPDB 189 3e-48 4V8R-AB nrPDB 175 5e-44 4B2T-B nrPDB 160 2e-39 5GW5-q nrPDB 154 9e-38 4V8R-AG nrPDB 142 4e-34 5X9V-A nrPDB 132 3e-31 4B2T-Q nrPDB 122 4e-28 1GN1-A nrPDB 91 2e-18 1ASS-A nrPDB 79 7e-15 1E0R-B nrPDB 77 2e-14 1IOK-A nrPDB 52 9e-07 5DA8-A nrPDB 51 1e-06 4V4O-A nrPDB 51 1e-06 1SJP-A nrPDB 48 1e-05 4AAR-A nrPDB 46 4e-05 4PJ1-A nrPDB 43 4e-04 5OGZ-A nrPDB 36 0.037 5CDI-A nrPDB 35 0.091 5NNN-A nrPDB 30 1.8 6NHX-A nrPDB 30 2.3 3H8L-A nrPDB 29 5.0 6NOD-A nrPDB 28 8.0 >5GW5-z nrPDB Length = 546 Score = 1115 bits (2885), Expect = 0.0, Method: Compositional matrix adjust. Identities = 546/546 (100%), Positives = 546/546 (100%) Query: 1 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGK 60 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGK Sbjct: 1 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGK 60 Query: 61 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD 120 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD Sbjct: 61 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD 120 Query: 121 GFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS 180 GFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS Sbjct: 121 GFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS 180 Query: 181 VYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSL 240 VYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSL Sbjct: 181 VYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSL 240 Query: 241 EYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKG 300 EYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKG Sbjct: 241 EYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKG 300 Query: 301 IDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG 360 IDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG Sbjct: 301 IDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG 360 Query: 361 EEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYI 420 EEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYI Sbjct: 361 EEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYI 420 Query: 421 ALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDA 480 ALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDA Sbjct: 421 ALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDA 480 Query: 481 QDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRST 540 QDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRST Sbjct: 481 QDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRST 540 Query: 541 LKETPQ 546 LKETPQ Sbjct: 541 LKETPQ 546 >4B2T-Z nrPDB Length = 531 Score = 615 bits (1587), Expect = e-176, Method: Compositional matrix adjust. Identities = 309/541 (57%), Positives = 405/541 (74%), Gaps = 13/541 (2%) Query: 2 SLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKV 61 +++ LNPKAE R AAL VN+++A GLQ VL TNLGPKGT+KMLV GAG+IKLTKDG V Sbjct: 3 AVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNV 62 Query: 62 LLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDG 121 LL EMQIQ PTA LIA+ A AQD+ITGDGTT+ V ++GELL+QA +I EG+HPRIIT+G Sbjct: 63 LLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEG 122 Query: 122 FEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSV 181 FE A++++++FL++ K+SK DRE L+ VAR+SL TKV A+L +VLT V D++L++ Sbjct: 123 FEAAKEKALQFLEQVKVSK---EMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAI 179 Query: 182 YDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLE 241 Q + +DL MVEIM+M+H S DT+ I+GLVLDHG RHPDM RV++AY+L NVSLE Sbjct: 180 -KKQDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLE 238 Query: 242 YEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGI 301 YEKTEVNSGFFY SA++R+KL +ERKF++ ++KKII+LK +VCG D DKGFV+INQKGI Sbjct: 239 YEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCG-DSDKGFVVINQKGI 297 Query: 302 DPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGE 361 DP SLD AK I+ALRRAKRRNMERL L GG A NS++DL+P LG +GLVY+ T+GE Sbjct: 298 DPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGE 357 Query: 362 EKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIA 421 EKFT++ + +P+S T+LIKG + L Q KDA+RDGLRAV N + D ++PGAGA +A Sbjct: 358 EKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVA 417 Query: 422 LSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQ 481 ++ L K KG+ + G++AFA+ALL+IPK L +NSGFD + L V+ A+ Sbjct: 418 MAEALVK---YKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQ-----AE 469 Query: 482 DSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTL 541 S+ + VGVDLN G+ GIWD+Y V + + T IA+N+LL DE++RAG S+L Sbjct: 470 HSESGQLVGVDLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSL 529 Query: 542 K 542 K Sbjct: 530 K 530 >3J1E-A nrPDB Length = 553 Score = 297 bits (760), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 178/529 (33%), Positives = 301/529 (56%), Gaps = 21/529 (3%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 A++ N+ + + ++ L++ GP+G KMLVD G+I +T DG +L +M +Q P A L+ Sbjct: 31 AVRANIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQHPAAKLLV 90 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 + A QDE T DGT T V GEL+++A + + VHP II G++ A + +++ + E Sbjct: 91 QIAKGQDEETADGTKTAVIFSGELVKKAEDLLYKDVHPTIIISGYKKAEEVALQTIQEL- 149 Query: 138 ISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADN--LDLHMVE 195 ++T ND + L ++A +SL +K A E + IV AV V + + D +DL ++ Sbjct: 150 -AQTVSINDTDLLRKIAMTSLSSKAVAGAREYIADIVVKAVTQVAELRGDKWYVDLDNIQ 208 Query: 196 IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSS 255 I++ S DT + G+V+D HP MP R++NA + +++ SLE EK E+++ + Sbjct: 209 IVKKAGGSINDTQLVYGIVVDKEVVHPGMPKRLENAKIALIDASLEVEKPELDAEIRIND 268 Query: 256 ADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNIL 315 Q K E + K+ KI+ G + VII QKGID ++ AK +L Sbjct: 269 PTQMQKFLDEEENLIKEKVDKIL-----ATGAN-----VIICQKGIDEVAQSYLAKKGVL 318 Query: 316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKS 375 A+RRAK+ ++E+L TGG ++++++S Q LG++ L+ + +GE+K +V +PKS Sbjct: 319 AVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGYASLIEERKVGEDKMVFVEGAKNPKS 378 Query: 376 CTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLG 435 +ILI+G + +T+ A+RD L VA+V+KD I G GA I +++ LR ++G Sbjct: 379 ISILIRGGLERLVDETERALRDALGTVADVIKDGRAIAGGGAVEIEIAKKLRK-YAPQVG 437 Query: 436 AKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNI 495 GK + +EA+A AL + L++N+GFDP+D+L +L +++ ++ G+DL Sbjct: 438 --GKEQLAVEAYANALESLVSILIENAGFDPIDLLM----KLRSTHENENNKWYGIDLYA 491 Query: 496 GDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKET 544 G D +G+ + V NAI AT A+ +L D+++ AG+ + E+ Sbjct: 492 GQPVDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVSAGKKSGGES 540 >4XCG-B nrPDB Length = 557 Score = 284 bits (727), Expect = 5e-77, Method: Compositional matrix adjust. Identities = 178/528 (33%), Positives = 295/528 (55%), Gaps = 21/528 (3%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 AL+ N+ + + ++ L++ GP+G KMLVD G+I +T DG +L +M +Q PT L+ Sbjct: 33 ALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQHPTGKLLV 92 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 + A QDE T DGT T V L GEL ++A + + +HP II G++ A + ++K + E Sbjct: 93 QIAKGQDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVSGYKKAEEIALKTIQE-- 150 Query: 138 ISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADN--LDLHMVE 195 I++ ND + L +VA +SL +K A E L +V AV V + + D +DL V+ Sbjct: 151 IAQPVTINDTDVLRKVALTSLGSKAVAGAREYLADLVVKAVAQVAELRGDKWYVDLDNVQ 210 Query: 196 IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSS 255 I++ S DT + G+V+D HP MP R++NA + +L+ SLE EK E+++ + Sbjct: 211 IVKKHGGSVNDTQLVYGIVVDKEVVHPGMPKRIENAKIALLDASLEVEKPELDAEIRIND 270 Query: 256 ADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNIL 315 Q K E + K+ KI G + V+I QKGID ++ AK IL Sbjct: 271 PTQMHKFLEEEENILKEKVDKI-----AATGAN-----VVICQKGIDEVAQHYLAKKGIL 320 Query: 316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKS 375 A+RRAK+ ++E+L TGG +++++L+ Q LG++ LV + +GE+K +V +PKS Sbjct: 321 AVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVEERKVGEDKMVFVEGAKNPKS 380 Query: 376 CTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLG 435 +ILI+G + +T+ A+RD L VA+V++D + G GA I +++ LR ++G Sbjct: 381 VSILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAVEIEIAKRLRK-YAPQVG 439 Query: 436 AKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNI 495 GK + IEA+A A+ + L +N+G DP+D L +L +++ ++ G++L Sbjct: 440 --GKEQLAIEAYANAIEGLIMILAENAGLDPIDKLM----QLRSLHENETNKWYGLNLFT 493 Query: 496 GDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKE 543 G+ D G+ + V NA+ AT + +L D+++ AG+ + E Sbjct: 494 GNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGKKSGSE 541 >3J1C-A nrPDB Length = 563 Score = 273 bits (699), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 172/531 (32%), Positives = 295/531 (55%), Gaps = 28/531 (5%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 ALK N+ +A L +L ++LGPKG KML+D G++ +T DG ++ EM+IQ P A L+ Sbjct: 22 ALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIVKEMEIQHPAAKLLV 81 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 AA AQD GDGTT+ V L G L +A + + +HP II +GF+ A +S++ L + Sbjct: 82 EAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHPTIIIEGFKKAFNKSLELLPQLA 141 Query: 138 ----ISKTNLSNDREFLLQVARSSLLTKVDADLTEV--LTPIVTDAVLSVYDAQAD---N 188 +S N + R+ L ++ +++ +K A+ E+ + IV DAV +V + D N Sbjct: 142 TKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNKIMDIVIDAVTTVAEPLPDGGYN 201 Query: 189 LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVN 248 + L +++I + + + +D+ I+G+VLD H MP RV+ A + +L+ SLE EK E++ Sbjct: 202 VSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVVHAGMPRRVEKAKIAVLDASLEVEKPEIS 261 Query: 249 SGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDV 308 + +S DQ + F+D + K + D+ +++ + + V+I QKGID ++ Sbjct: 262 AKISITSPDQI-------KAFLDEEAKYLKDMVDKLASIGAN---VVICQKGIDDIAQHF 311 Query: 309 FAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVT 368 AK ILA+RR KR ++E+L+ G +S++D +P+ LG++ LV + +G +K ++ Sbjct: 312 LAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERKVGNDKMVFIE 371 Query: 369 ENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRS 428 +PK+ IL++GS AL + + ++ D L ++ N+L + I+PG GA + LS LR Sbjct: 372 GAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILMEPYIVPGGGAIELELSARLRE 431 Query: 429 ANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRY 488 + GK + IEA+A+AL IP L + +G +P+ L + A+ + Sbjct: 432 YARS---VGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDLR-----ARHAKGLTN 483 Query: 489 VGVDLNIGDSCDPTIE-GIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 GVD+ G D + + RV R + AT A++++ D+L+ A + Sbjct: 484 CGVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDLIAASQ 534 >1A6E-A nrPDB Length = 545 Score = 273 bits (697), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 176/524 (33%), Positives = 283/524 (54%), Gaps = 22/524 (4%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 A + N+ +A+ + + T LGPKG KMLVD G+I ++ DG +L EM ++ PTA +I Sbjct: 23 AQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISNDGATILKEMDVEHPTAKMIV 82 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 + AQD GDGTTT V L GELL+QA + +GVHP +I++G+ +A E+ K +DE Sbjct: 83 EVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVISNGYRLAVNEARKIIDEIA 142 Query: 138 ISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIM 197 T+ + R+ L A S T + D L +AV V D + +D +++ Sbjct: 143 EKSTDDATLRKIAL-TALSGKNTGLSNDFLADLVVKAVNAVAEVRDGKT-IVDTANIKVD 200 Query: 198 QMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSAD 257 + S DT FI G+V+D H MP VKNA + +++ +LE +KTE+ + S Sbjct: 201 KKNGGSVNDTQFISGIVIDKEKVHSKMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPS 260 Query: 258 Q-RDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILA 316 + +D L F K V + V++ QKGID ++ AK I A Sbjct: 261 KIQDFLNQETNTF-----------KQMVEKIKKSGANVVLCQKGIDDVAQHYLAKEGIYA 309 Query: 317 LRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSC 376 +RR K+ +ME+L TG + ++DL+P +LG + V + IG+++ T+V +PK+ Sbjct: 310 VRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVEERKIGDDRMTFVMGCKNPKAV 369 Query: 377 TILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGA 436 +ILI+G T + +++ + A+ D +R VA +D + G GA L+ L + N +G Sbjct: 370 SILIRGGTDHVVSEVERALNDAIRVVAITKEDGKFLWGGGAVEAELAMRL-AKYANSVG- 427 Query: 437 KGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIG 496 G+ + IEAFA+AL +IP+TL +N+G DP++ L ++ A D VGVDL+ Sbjct: 428 -GREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLK-----ADDEKGRISVGVDLDNN 481 Query: 497 DSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRST 540 D +G+ D RV +A+ A +A+ +L D+++ + +ST Sbjct: 482 GVGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASKKST 525 >1Q3S-A nrPDB Length = 548 Score = 267 bits (682), Expect = 9e-72, Method: Compositional matrix adjust. Identities = 170/524 (32%), Positives = 285/524 (54%), Gaps = 23/524 (4%) Query: 15 RDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAV 74 RDA ++N+ +A + + T LGPKG KMLVD G+I +T D +L ++ +Q P A Sbjct: 22 RDAQ-RLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDCATILDKIDLQHPAAK 80 Query: 75 LIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLD 134 ++ A QD+ GDGTTT V + GELLR+A + + +HP II G+ +A +++ + LD Sbjct: 81 MMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSIIIKGYALAAEKAQEILD 140 Query: 135 EFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADN--LDLH 192 E I +D E LL++A +S+ K E+L + +AV V + + +DL Sbjct: 141 EIAIRVD--PDDEETLLKIAATSITGKNAESHKELLAKLAVEAVKQVAEKKDGKYVVDLD 198 Query: 193 MVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFF 252 ++ + +++ ++G+V+D HP MP RV+NA + ++N +LE +KTE ++ Sbjct: 199 NIKFEKKAGEGVEESELVRGVVIDKEVVHPRMPKRVENAKIALINEALEVKKTETDAKIN 258 Query: 253 YSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKH 312 +S DQ E K LK+ V + V+ QKGID ++ AK+ Sbjct: 259 ITSPDQLMSFLEQEEKM----------LKDMVDHIAQTGANVVFVQKGIDDLAQHYLAKY 308 Query: 313 NILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTD 372 I+A+RR K+ +ME+L TG + +V+DL+P+ LG++ +V + + E +V + Sbjct: 309 GIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAGENMIFVEGCKN 368 Query: 373 PKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMN 432 PK+ TILI+G T + + + + A+ D ++ V +V++D ++P GA I L+ L Sbjct: 369 PKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIELAIRL-DEYAK 427 Query: 433 KLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVD 492 ++G GK IE FA+AL +IPKTL +N+G D +++L V E + +G+D Sbjct: 428 QVG--GKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISE-----HKNRGLGIGID 480 Query: 493 LNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRA 536 + G D +GI + RV + AI A+ A +L D+++ A Sbjct: 481 VFEGKPADMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDVIAA 524 >4XCI-A nrPDB Length = 559 Score = 260 bits (664), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 170/529 (32%), Positives = 293/529 (55%), Gaps = 28/529 (5%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 AL+ N+ +A+ L +L ++LGPKG KML+D G++ +T DG ++ +M+IQ P A L+ Sbjct: 20 ALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIVKDMEIQHPAAKLLV 79 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEF- 136 AA AQD GDGTT+ V L G LL +A + + +HP II +G++ A ++++ L + Sbjct: 80 EAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYKKAYNKALELLPQLG 139 Query: 137 ---KISKTNLSNDREFLLQVARSSLLTKVDADLTEV--LTPIVTDAVLSVYDAQAD---N 188 I N S R+ L ++A ++L +K A+ E+ + +V DA+++V + + N Sbjct: 140 TRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIIDMVIDAIVNVAEPLPNGGYN 199 Query: 189 LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVN 248 + L +++I + + S +D+ +KGLVLD HP MP RV A + +L+ +LE EK E++ Sbjct: 200 VSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVTKAKIAVLDAALEVEKPEIS 259 Query: 249 SGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDV 308 + +S +Q + F+D + K + D+ +++ + + V+I QKGID ++ Sbjct: 260 AKISITSPEQI-------KAFLDEESKYLKDMVDKLASIGAN---VVICQKGIDDIAQHF 309 Query: 309 FAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVT 368 AK ILA+RR KR ++E+L+ G +S++D +P+ LG++ LV + +G +K ++ Sbjct: 310 LAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRVGNDKMVFIE 369 Query: 369 ENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRS 428 + K+ IL++GS AL + + ++ D L A+ N+L + I+PG GA + L+ LR Sbjct: 370 GAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGGGAIELELAMKLRE 429 Query: 429 ANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRY 488 + GK + IEAFA+AL IP L + +G + + L + A+ + Sbjct: 430 YARS---VGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLR-----ARHAKGLSN 481 Query: 489 VGVDLNIGDSCDPTIE-GIWDSYRVLRNAITGATGIASNLLLCDELLRA 536 GVD+ G D I + RV + AT A+ +L D+L+ A Sbjct: 482 TGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAA 530 >1A6D-B nrPDB Length = 543 Score = 251 bits (640), Expect = 7e-67, Method: Compositional matrix adjust. Identities = 163/519 (31%), Positives = 288/519 (55%), Gaps = 22/519 (4%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 A+K N+ +A + + + ++LGP+G KMLVD G+I +T DG +L EM ++ P A ++ Sbjct: 22 AMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDGVTILKEMDVEHPAAKMMV 81 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 + QD GDGTTT V + G LL+QA I + VHP +I++G+ +A +E+ + +DE Sbjct: 82 EVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTVISEGYRMASEEAKRVIDE-- 139 Query: 138 ISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADN--LDLHMVE 195 IS ++++ LL++A++SL +K + + L I +AV SV + + +D ++ Sbjct: 140 ISTKIGADEKALLLKMAQTSLNSKSASVAKDKLAEISYEAVKSVAELRDGKYYVDFDNIQ 199 Query: 196 IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSS 255 +++ Q + DT I G+++D HP MP VK+A + +L+ LE +K E ++ Sbjct: 200 VVKKQGGAIDDTQLINGIIVDKEKVHPGMPDVVKDAKIALLDAPLEIKKPEFDTNLRIED 259 Query: 256 ADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNIL 315 K A E L++++D K + G + V+I QKGID M+ ++ I Sbjct: 260 PSMIQKFLAQEENM----LREMVD-KIKSVGAN-----VVITQKGIDDMAQHYLSRAGIY 309 Query: 316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKS 375 A+RR K+ +M++L TG ++++++S LG + V Q +GE+ T+VT +PK+ Sbjct: 310 AVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVGEDYMTFVTGCKNPKA 369 Query: 376 CTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLG 435 +IL++G T + + + + ++ D L VA+ L+D G GA ++ LRS K+G Sbjct: 370 VSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAAEIAFRLRS-YAQKIG 428 Query: 436 AKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNI 495 G+ + IE FA+A+ IP+ L +N+G DP+D+L + A+ + + G+++ Sbjct: 429 --GRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLR-----AEHAKGNKTYGINVFT 481 Query: 496 GDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELL 534 G+ D G+ + RV + AI AT A +L D+++ Sbjct: 482 GEIEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVI 520 >3RUW-A nrPDB Length = 543 Score = 247 bits (631), Expect = 8e-66, Method: Compositional matrix adjust. Identities = 162/522 (31%), Positives = 270/522 (51%), Gaps = 21/522 (4%) Query: 15 RDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAV 74 RDA ++N+ + + + + LGPKG KMLVD G++ +T DG +L EM ++ P A Sbjct: 18 RDAQ-RMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHPAAK 76 Query: 75 LIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLD 134 ++ A Q++ GDGTTT V + GELLR+A + + VHP I+ G++ A +++ + L Sbjct: 77 MLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQKAQELLK 136 Query: 135 EFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMV 194 I+ + D+E L ++A +S+ K E L I+ +AV +V D + +D ++ Sbjct: 137 --TIACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEG-KVDKDLI 193 Query: 195 EIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYS 254 +I + S DT IKG+++D MP +V +A + +LN ++E ++TE ++ + Sbjct: 194 KIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNCAIEIKETETDAEIRIT 253 Query: 255 SADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNI 314 + + E K LK+ V + V+ QKGID ++ AK I Sbjct: 254 DPAKLMEFIEQEEKM----------LKDMVAEIKASGANVLFCQKGIDDLAQHYLAKEGI 303 Query: 315 LALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPK 374 +A RR K+ +ME+L TG ++ LS Q LG +GLV + I + +V E PK Sbjct: 304 VAARRVKKSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEERKISGDSMIFVEECKHPK 363 Query: 375 SCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKL 434 + T+LI+G+T + + + AV D + V ++D I+ G G+ + LS LR Sbjct: 364 AVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLRE---YAE 420 Query: 435 GAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLN 494 G G+ + + AFA+AL VIP+TL +N+G D +++L V A S+ + G+++ Sbjct: 421 GISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVR----AAHASNGNKCAGLNVF 476 Query: 495 IGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRA 536 G D G+ + RV AI A LL D+++ A Sbjct: 477 TGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAA 518 >3IYF-A nrPDB Length = 521 Score = 241 bits (614), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 160/522 (30%), Positives = 264/522 (50%), Gaps = 43/522 (8%) Query: 15 RDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAV 74 RDA ++N+ + + + + LGPKG KMLVD G++ +T DG +L EM ++ P A Sbjct: 18 RDAQ-RMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHPAAK 76 Query: 75 LIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLD 134 ++ A Q++ GDGTTT V + GELLR+A + + VHP I+ G++ A +++ + L Sbjct: 77 MLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQKAQELLK 136 Query: 135 EFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMV 194 I+ + D+E L ++A +S+ K E L I+ +AV +V D + +D ++ Sbjct: 137 --TIACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEG-KVDKDLI 193 Query: 195 EIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYS 254 +I + S DT IKG+++D MP +V +A + +LN ++E +E+ Sbjct: 194 KIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNCAIEETASEM------- 246 Query: 255 SADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNI 314 LK+ V + V+ QKGID ++ AK I Sbjct: 247 -------------------------LKDMVAEIKASGANVLFCQKGIDDLAQHYLAKEGI 281 Query: 315 LALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPK 374 +A RR K+ +ME+L TG +++DLS Q LG +GLV + I + +V E PK Sbjct: 282 VAARRVKKSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEERKISGDSMIFVEECKHPK 341 Query: 375 SCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKL 434 + T+LI+G+T + + + AV D + V ++D I+ G G+ + LS LR Sbjct: 342 AVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLRE---YAE 398 Query: 435 GAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLN 494 G G+ + + AFA+AL VIP+TL +N+G D +++L V A S+ + G+++ Sbjct: 399 GISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVR----AAHASNGNKCAGLNVF 454 Query: 495 IGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRA 536 G D G+ + RV AI A LL D+++ A Sbjct: 455 TGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAA 496 >4B2T-G nrPDB Length = 545 Score = 233 bits (594), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 157/537 (29%), Positives = 286/537 (53%), Gaps = 36/537 (6%) Query: 10 AESLRRDAALKV---NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEM 66 +++ +R++ KV N+ +A+ + ++ T LGPK +KML+D G I +T DG +L E+ Sbjct: 11 SQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREI 70 Query: 67 QIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIAR 126 Q+Q P A + + QDE GDGTT+V+ L GE+L A F+++ +HP ++ + A Sbjct: 71 QVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKAL 130 Query: 127 KESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQA 186 + + L KIS +++R+ +L + SS+ TKV + + + I DAV +V + Sbjct: 131 DDMISTLK--KISIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEEN 188 Query: 187 DNLDLHMVEIMQMQHLSP---KDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYE 243 ++ + + +++ + +D+ ++G++++ HP M +KN +++L+ SLEY+ Sbjct: 189 GRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYK 248 Query: 244 KTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDP 303 K E + + + ++ E +++ + II LK PD V+I +KGI Sbjct: 249 KGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLK-------PD---VVITEKGISD 298 Query: 304 MSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGF-SGLVYQETIGEE 362 ++ + NI A+RR ++ + R+ G + E+L + +G +GL+ + IG+E Sbjct: 299 LAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDE 358 Query: 363 KFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIAL 422 FT++TE DPK+CTIL++G++ L++ + ++D ++ NVL D ++PG GA +A+ Sbjct: 359 YFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAV 418 Query: 423 SRYLRSANMNKLGAKGKTKTGIE-----AFAEALLVIPKTLVKNSGFDPLDVLAMVEDEL 477 + + L K K TG+E A A+AL VIP+TL++N G + +L + + Sbjct: 419 A--------HALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAK- 469 Query: 478 DDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELL 534 Q++ ET GV+ G D GIW+ V A A LL D+++ Sbjct: 470 -HTQENCET--WGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIV 523 >3AQ1-B nrPDB Length = 500 Score = 231 bits (588), Expect = 8e-61, Method: Compositional matrix adjust. Identities = 152/493 (30%), Positives = 256/493 (51%), Gaps = 23/493 (4%) Query: 45 MLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQ 104 MLVD G+I +T DG +L EM IQ P A +I + QD GDGTTT L GELL + Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 105 AHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDA 164 A I +GVH II++G+ A ++ + L+ I+ + +D L+++A +++ K Sbjct: 61 AEELIMKGVHSTIISEGYRHAAEKCREILETITIAIS--PDDEAALIKIAGTAITGKGAE 118 Query: 165 DLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQMQHL---SPKDTTFIKGLVLDHGGRH 221 E L+ + AV S+ + + D L ++++E ++++ S D+ I GLV+D H Sbjct: 119 AYKEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKERSH 178 Query: 222 PDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLK 281 P+MP +V+NA +L+L+ +E+ KTEV+S +S Q E K + +K+I Sbjct: 179 PNMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKVI--- 235 Query: 282 NEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVE 341 V+ QKGID M+ K I A+RR K+ +++RL VTG ++ Sbjct: 236 -------ASGANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLD 288 Query: 342 DLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRA 401 ++ + +G +GLV ++ + K TYVT + K+ T+L+ G T + + A+ D L Sbjct: 289 QITTEDVGTAGLVEEKEVRGGKMTYVTGCQNSKAVTVLLHGGTEHVVDSLDHALNDALHV 348 Query: 402 VANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKN 461 V V++D ++ G G+ + LS L S + L KG+ + + FAEAL VIP L +N Sbjct: 349 VGVVIEDGKVVVGGGSSEVELSLRL-SEYASTL--KGREQLAVSKFAEALEVIPVALAEN 405 Query: 462 SGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGAT 521 +G DP+D++ + +Q + G+++ G+ D + + R+ AI A Sbjct: 406 AGLDPIDIMVELR-----SQHEKGNKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAM 460 Query: 522 GIASNLLLCDELL 534 +L D+++ Sbjct: 461 EATVMILRIDDVV 473 >4B2T-H nrPDB Length = 543 Score = 212 bits (540), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 139/529 (26%), Positives = 260/529 (49%), Gaps = 27/529 (5%) Query: 22 NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAA 81 N+++ + + + T LGP+G K++VDG G ++ DG +L + + P A + A Sbjct: 25 NISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAK 84 Query: 82 AQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKIS-- 139 +QD GDGTT+V L E L+Q +++EG+HP+II F A + ++ + E ++ Sbjct: 85 SQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVK 144 Query: 140 KTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQM 199 K + R+ L + A ++L +K+ + +V DAV+ + D L L M+ I ++ Sbjct: 145 KEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDL----LQLKMIGIKKV 200 Query: 200 QHLSPKDTTFIKGLVLDHGGRHPDM---PTRVKNAYVLILNVSLEYEKTEVNSGFFYSSA 256 Q + +++ + G+ + P + N + +LNV LE + + N+ + Sbjct: 201 QGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNPMIALLNVELELKAEKDNAEIRVHTV 260 Query: 257 DQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILA 316 + + +E + KL+KI V++++ I ++ FA ++ Sbjct: 261 EDYQAIVDAEWNILYDKLEKI----------HHSGAKVVLSKLPIGDVATQYFADRDMFC 310 Query: 317 LRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSC 376 R +++R + GG Q SV LS +LG + + IG E++ + T K+C Sbjct: 311 AGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIGGERYNFFTGCPKAKTC 370 Query: 377 TILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGA 436 TI+++G + +T+ ++ D + V +K+ +++ G GA + LS+YLR + Sbjct: 371 TIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRT---I 427 Query: 437 KGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIG 496 GK + I A+A+AL +IP+ L N+GFD ++L + A+ + + GVD+N Sbjct: 428 PGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLR-----ARHAQGGMWYGVDINTE 482 Query: 497 DSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKETP 545 D D +W+ V NA+T A+ A ++ DE ++ RST+ +P Sbjct: 483 DIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDASP 531 >5GW5-g nrPDB Length = 534 Score = 202 bits (515), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 149/534 (27%), Positives = 269/534 (50%), Gaps = 43/534 (8%) Query: 22 NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAA 81 N+T+A+ + V+ T LGPK LKML+D G + LT DG +L E+ + P A + + Sbjct: 24 NITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSR 83 Query: 82 AQDEITGDGTTTVVCLVGELLRQ-AHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISK 140 QDE GDGTTTV+ L GE+L Q A I++ +HP II + A ++++ + + +SK Sbjct: 84 TQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQ--VSK 141 Query: 141 -TNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQAD------NLDLHM 193 ++ ND + ++ ++S+ TK +E + + DAV +V N ++ + Sbjct: 142 PVDVEND-AAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDI 200 Query: 194 VEIMQMQHLSPK---DTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSG 250 ++++ + D+ +KG++L+ HP M ++N V++L+ LEY+K E + Sbjct: 201 KRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTN 260 Query: 251 FFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFA 310 + +++ E + V ++I+ ++ ++I +KG+ ++ Sbjct: 261 IEIEKEEDWNRILQIEEEQVQLMCEQILAVRP----------TLVITEKGVSDLAQHYLL 310 Query: 311 KHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFS-GLVYQETIGEEKFTYVTE 369 K LRR K+ + R+ VTG N VEDL +G + GL E IG+E F+++ Sbjct: 311 KGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDN 370 Query: 370 NTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSA 429 +PK+CTI+++G + L + ++D + NV+ ++ PG GA +A+S Sbjct: 371 CKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSV----- 425 Query: 430 NMNKLGAKGKTKTGI-----EAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSD 484 KL K K GI +A A+A+ IP+TL++N+G DP+ +L+ + A+ + Sbjct: 426 ---KLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR-----AKHAQ 477 Query: 485 ETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 G+D + G D GIW+ + + ++ A A LL D+++ R Sbjct: 478 GNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVR 531 >5UYZ-A nrPDB Length = 541 Score = 201 bits (512), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 144/526 (27%), Positives = 268/526 (50%), Gaps = 23/526 (4%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 ALK ++ +A+ + + + T+LGP G KM+VD G++ +T DG +L+ M + A L+ Sbjct: 33 ALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMV 92 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 + +QD+ GDGTT VV L G LL +A + + G+HP I DG+E A + +++ LD K Sbjct: 93 ELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIERLD--K 150 Query: 138 ISKTNLSN--DREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVE 195 IS + L + D E L+Q A+++L +KV + I +AVL+V D + ++D +++ Sbjct: 151 ISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIK 210 Query: 196 IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSS 255 + +DT IKG+++D HP MP +V++A + IL E K + +S Sbjct: 211 VEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTS 270 Query: 256 ADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNIL 315 + L E++ + +++I + + I Q G D + + ++N+ Sbjct: 271 VEDYKALQKYEKEKFEEMIQQIKETGANLA----------ICQWGFDDEANHLLLQNNLP 320 Query: 316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG--EEKFTYVTENTDP 373 A+R +E + + TGG +L+ + LGF+GLV + + G ++K + + + Sbjct: 321 AVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNS 380 Query: 374 KSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNK 433 ++ TI I+G + + K ++ D L + N+++D ++ G GA I+ + + S +K Sbjct: 381 RAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAV-SQEADK 439 Query: 434 LGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDL 493 + + AFA+AL VIP L +NSG +P+ + E+ Q + +G+D Sbjct: 440 --CPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMT----EVRARQVKEMNPALGIDC 493 Query: 494 NIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRS 539 + D + + ++ + I+ AT + +L D++ + G S Sbjct: 494 LHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGES 539 >4B2T-A nrPDB Length = 556 Score = 199 bits (506), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 139/526 (26%), Positives = 271/526 (51%), Gaps = 26/526 (4%) Query: 22 NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAA 81 NV +A + ++++++LGP G KMLVD G++ +T DG +L ++++ P A ++ A Sbjct: 21 NVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELAD 80 Query: 82 AQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKT 141 QD+ GDGTT+VV + ELL+ A +++ +HP + G+ +A KE+++++ E I T Sbjct: 81 LQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYISENLIINT 140 Query: 142 NLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSV--YDAQAD-NLDLHMVEIMQ 198 + R+ L+ A++S+ +KV + +V DAVL++ D + ++ + +++ Sbjct: 141 D-ELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIRGQPRYPVNSINVLK 199 Query: 199 MQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQ 258 S ++ I G L+ MP R+ NA + L+ SL+ K ++ + ++ Sbjct: 200 AHGRSQMESMLINGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEK 259 Query: 259 RDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALR 318 D++ E +++KI+ VI+ GID M L F + +A+R Sbjct: 260 LDQIRQRESDITKERIQKIL----------ATGANVILTTGGIDDMCLKYFVEAGAMAVR 309 Query: 319 RAKRRNMERLQLVTGGEAQNSVEDLSPQ------ILGFSGLVYQETIGEEKFTYVTENTD 372 R +R+++R+ +G +++ +L + +LG + V QE I +++ + Sbjct: 310 RVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELILIKNTKA 369 Query: 373 PKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMN 432 S +++++G+ + + + ++ D L V VL+ K+++PG GA ALS YL + Sbjct: 370 RTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENY-AT 428 Query: 433 KLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDET---RYV 489 +G+ + + I FA +L VIP TL N+ D D++A + ++AQ + E +++ Sbjct: 429 SMGS--REQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWI 486 Query: 490 GVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLR 535 G+DL G D G+++ V ++ AT A +L D+L++ Sbjct: 487 GLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIK 532 >4V8R-AE nrPDB Length = 562 Score = 197 bits (502), Expect = 8e-51, Method: Compositional matrix adjust. Identities = 151/531 (28%), Positives = 267/531 (50%), Gaps = 27/531 (5%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 A K ++ +A + S+++T+LGP+G K+L+ G I +T DG +L++M++ + A L+ Sbjct: 46 AKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELDNEIAKLLV 105 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEF- 136 + + +QD+ GDGTT VV L LL QA IQ+G+HP I +GF+ A K ++ L+E Sbjct: 106 QLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLAISKLEETC 165 Query: 137 -KISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVE 195 IS +N R+FLL+ A++SL +K+ + + + +AV++V D ++D +++ Sbjct: 166 DDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRKDVDFDLIK 225 Query: 196 IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRV------KNAYVLILNVSLEYEKTEVNS 249 + S D+ I G++LD HP MP V + IL E K + Sbjct: 226 MQGRVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPFEPPKPKTKH 285 Query: 250 GFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVF 309 SS ++ KL E+ K K++ID + G D V+I Q G D + + Sbjct: 286 KLDISSVEEYQKLQTYEQD----KFKEMID-DVKKAGAD-----VVICQWGFDDEANHLL 335 Query: 310 AKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG--EEKFTYV 367 ++++ A+R + +E + + T G +DLS LG +Y++ G +++ + Sbjct: 336 LQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEFGTTKDRMLII 395 Query: 368 TENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLR 427 ++ + K+ T ++GS + + + A+ D L V N++KD ++ G GA + +S + Sbjct: 396 EQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGGAAEVTMSLAV- 454 Query: 428 SANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETR 487 S +K +G + FA+AL IP TL +NSG DP+ L+ L Q ++ Sbjct: 455 SEEADK--QRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLST----LKSKQLKEKIS 508 Query: 488 YVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 +GVD S D + D + + I AT + +L D ++ +G+ Sbjct: 509 NIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGK 559 >4B2T-D nrPDB Length = 542 Score = 193 bits (491), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 147/525 (28%), Positives = 272/525 (51%), Gaps = 37/525 (7%) Query: 22 NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAA 81 N+++A+ + + T+LGPKG KM+ DG G++ +T DG +L +MQ+ P A ++ + Sbjct: 40 NISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSK 99 Query: 82 AQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKT 141 AQD GDGTT+VV + G LL + +Q+G+HP II++ F+ A ++ ++ L + S+ Sbjct: 100 AQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDM--SRP 157 Query: 142 NLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYD-AQADNLDLHMVEIMQMQ 200 +DRE LL A +SL +KV + + +L+P+ DAV+ V D A A ++DL ++I++ Sbjct: 158 VELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATATSVDLRDIKIVKKL 217 Query: 201 HLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRD 260 + D ++GLVL + + TRV+ A + ++ L KT++++ S Q D Sbjct: 218 GGTIDDCELVEGLVLTQKVANSGI-TRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYVQMD 276 Query: 261 KLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGI-----DPMSLDVFAKHNIL 315 ++ ER ++ +K+I K C V++ QK I ++L K I+ Sbjct: 277 RVLREERAYILNLVKQI---KKTGCN-------VLLIQKSILRDALSDLALHFLNKMKIM 326 Query: 316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETI-GEEKFTYVTENTDP- 373 ++ +R ++E + G + V+ + +LG + L + ++ G K +T P Sbjct: 327 VVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSGKLIKITGCASPG 386 Query: 374 KSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGA----FYIALSRYLRSA 429 K+ TI+++GS + + + ++ D L + ++K + +I G GA + L+ Y R+ Sbjct: 387 KTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTL 446 Query: 430 NMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYV 489 + G I AFA+A+ VIP TL +N+G +P+ + EL + E + Sbjct: 447 S-------GMESYCIRAFADAMEVIPSTLAENAGLNPISTVT----ELRNRHAQGE-KTT 494 Query: 490 GVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELL 534 G+++ G + E + V +A+T AT ++L D+++ Sbjct: 495 GINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVV 539 >4V94-A nrPDB Length = 559 Score = 190 bits (482), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 142/532 (26%), Positives = 260/532 (48%), Gaps = 38/532 (7%) Query: 22 NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAA 81 NV + + +V++++LGP G KMLVD G+ +T DG +L+ + +Q P ++ A Sbjct: 29 NVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDVQHPAGKILVELAQ 88 Query: 82 AQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKT 141 QD GDGTT+VV + ELL++A+ ++ +HP I GF +A +E+++F++E +S + Sbjct: 89 QQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGFRVALREAIRFINEV-LSTS 147 Query: 142 NLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQAD---NLDLHMVEIMQ 198 + +E L+ +A++S+ +K+ ++ + +V DA+L+V + + V +++ Sbjct: 148 VDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKTQNSKGEIKYPVKAVNVLK 207 Query: 199 MQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSAD- 257 S ++ + G L+ MP R+ V I + L +K + G + D Sbjct: 208 AHGKSATESLLVPGYALNCTVASQAMPKRIAGGNVKIACLDLNLQKARMAMGVQINIDDP 267 Query: 258 -QRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILA 316 Q +++ E V ++KKIID + V++ KGID + L F + I+ Sbjct: 268 EQLEQIRKREAGIVLERVKKIIDAGAQ----------VVLTTKGIDDLCLKEFVEAKIMG 317 Query: 317 LRRAKRRNMERLQLVTGGEAQNSVEDLSPQ------ILGFSGLVYQETIGEEKFTYVTEN 370 +RR K+ ++ R+ TG +S+ +L + LG V Q +++ + Sbjct: 318 VRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQAKFSDDECILIKGT 377 Query: 371 TDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSAN 430 + S +I+++G+ Y+L + + ++ D L V L+ N++PG G AL+ YL + Sbjct: 378 SKHSSSSIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVPGGGCVEAALNIYLDNF- 436 Query: 431 MNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVE-----DELDDAQDSDE 485 +G+ + + I FA ALL+IPKTL N+ D +++A + ++ +D Sbjct: 437 ATTVGS--REQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAKPEDVKR 494 Query: 486 TRY--VGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLR 535 Y G+DL G D G VL I+ + S L C +LR Sbjct: 495 RSYRNYGLDLIRGKIVDEIHAG------VLEPTISKVKSLKSALEACVAILR 540 >5GW4-h nrPDB Length = 550 Score = 189 bits (481), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 137/512 (26%), Positives = 254/512 (49%), Gaps = 26/512 (5%) Query: 22 NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAA 81 N+ + +Q L+ LGP G+ ++V ++ DG +L + + P A + + Sbjct: 29 NINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISR 88 Query: 82 AQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKT 141 AQD GDGTT+V L GEL+++A F++EG+ +I G+ A +++ ++E + T Sbjct: 89 AQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDIT 148 Query: 142 N-LSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQMQ 200 + S+ RE L + AR+++ +K+ + + + DAVLS+ ++LD ++ I ++ Sbjct: 149 SEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL---DRNDLDDKLIGIKKIP 205 Query: 201 HLSPKDTTFIKGLVLDHGGRHPDM---PTRVKNAYVLILNVSLEYEKTEVNSGFFYSSAD 257 + +++ FI G+ + P + N +L LNV LE + + N+ + Sbjct: 206 GGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVE 265 Query: 258 QRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILAL 317 + +E + + KL+++ E G + +++++ I ++ FA NI Sbjct: 266 DYQAIVDAEWQLIFEKLRQV-----EETGAN-----IVLSKLPIGDLATQFFADRNIFCA 315 Query: 318 RRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCT 377 R +M R+ GG Q++ D+ P+ LG L + IG E++ K+CT Sbjct: 316 GRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCT 375 Query: 378 ILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAK 437 +L++G +A+ + ++ D + V L++K I+ G GA + +S+ LR + Sbjct: 376 LLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKT---IA 432 Query: 438 GKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGD 497 GK + I AFA+AL VIP+ L +N+GFD +++L ++L A E Y GV + Sbjct: 433 GKQQMIINAFAKALEVIPRQLCENAGFDAIEIL----NKLRLAHSKGEKWY-GVVFETEN 487 Query: 498 SCDPTIEGIWDSYRVLRNAITGATGIASNLLL 529 D + +W+ V NA+ AT A+NL+L Sbjct: 488 IGDNFAKFVWEPALVKINALNSATE-ATNLIL 518 >5GW4-d nrPDB Length = 528 Score = 189 bits (480), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 147/523 (28%), Positives = 261/523 (49%), Gaps = 29/523 (5%) Query: 20 KVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARA 79 K N+ +A + + T+LGPKG KM+ G I ++ DG +L +M I P A ++ Sbjct: 22 KANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEV 81 Query: 80 AAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKIS 139 +AAQD GDGTT+VV L G LL A R + +G+HP II D F+ A K S+ L E Sbjct: 82 SAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEM-CH 140 Query: 140 KTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQM 199 K +LS DRE L++ A +SL +K+ + + L P+ D+VL + D + N+DL+ + +++ Sbjct: 141 KVSLS-DREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLVKK 199 Query: 200 QHLSPKDTTFIKGLVLDHGG-RHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQ 258 + DT I G+VL + PTR + A + ++ + K + + + Q Sbjct: 200 VGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQ 259 Query: 259 RDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALR 318 DK+ ER ++ KKI K V + I + ++ ++L +K NI+ ++ Sbjct: 260 MDKILKEERAYLLNICKKIKKAKCNVLLIQKS-----ILRDAVNDLALHFLSKLNIMVVK 314 Query: 319 RAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVT---ENTDPKS 375 +R +E L G + +E + LG + LV + K VT N + Sbjct: 315 DIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPT 374 Query: 376 CTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLG 435 +++I+G+ + + +T+ ++ D L + ++K++ +I G GA I +SR +L Sbjct: 375 VSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISR--------RLS 426 Query: 436 AKGKTKTGIEA-----FAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVG 490 + ++ G++A FA AL VIP TL +N+G + + V+ + + ++ + +D G Sbjct: 427 KEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND-----G 481 Query: 491 VDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDEL 533 + + + + E I V +AIT A+ ++L D++ Sbjct: 482 ISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 >4V8R-AB nrPDB Length = 527 Score = 175 bits (443), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 144/543 (26%), Positives = 271/543 (49%), Gaps = 33/543 (6%) Query: 1 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGN-IKLTKDG 59 MS+Q+ + R + A A + ++++ LGPKG K+L + N +T DG Sbjct: 1 MSVQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDG 60 Query: 60 KVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFI-QEGVHPRII 118 +L + + +P A ++ + QD+ GDGTT+V L ELLR+A + I Q +HP+ I Sbjct: 61 ATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTI 120 Query: 119 TDGFEIARKESMKFLDEFKISKTNLSND----REFLLQVARSSLLTKVDADLTEVLTPIV 174 +G+ R S LD + + S+D RE L+ +A+++L +K+ + + + Sbjct: 121 IEGY---RLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELA 177 Query: 175 TDAVLSVYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVL 234 T+A+L + + +L ++I+++ D+ +G +L + + P R++NA +L Sbjct: 178 TNAILRLKGST----NLEHIQIIKILGGKLSDSFLDEGFILAKKFGN-NQPKRIENAKIL 232 Query: 235 ILNVSLEYEKTEV-NSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGF 293 I N +L+ +K ++ + F S + +L +ER+ + K+ KI G++ Sbjct: 233 IANTTLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKF-----GIN----- 282 Query: 294 VIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGL 353 IN++ I +F I ++ A +ERL LVTGGE ++ ++ S LG + Sbjct: 283 TFINRQLIYDYPEQLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDV 342 Query: 354 VYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIP 413 + + +GE+ F + ++CTI+++G+T L + + ++ D L ++ K+ + Sbjct: 343 IEEIMLGEQPFLKFSGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVL 402 Query: 414 GAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMV 473 G G + +S+ + + N GK +EAFA AL +P L N+GFD ++++ + Sbjct: 403 GGGCAEMVMSKAVDTEAQN---IDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKL 459 Query: 474 EDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDEL 533 + + + G+DLN G D GI +SY++ R ++ A+ A LL D + Sbjct: 460 RSSIYNGISTS-----GLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNI 514 Query: 534 LRA 536 +RA Sbjct: 515 IRA 517 >4B2T-B nrPDB Length = 535 Score = 160 bits (404), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 139/549 (25%), Positives = 264/549 (48%), Gaps = 49/549 (8%) Query: 3 LQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGA--GNIKLTKDGK 60 + + A+ R + A + A + ++++ LGPKG K+L+ ++ +T DG Sbjct: 9 VNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGA 68 Query: 61 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD 120 +L + + +P A ++ + QD+ GDGTT+V L ELLR+A I + +HP+ I Sbjct: 69 TILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIA 128 Query: 121 GFEIARKESMKFL---------DEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLT 171 G+ A K + + L DE K R+ L+ +A ++L +K+ + T Sbjct: 129 GWREATKAARQALLNSAVDHGSDEVKF--------RQDLMNIAGTTLSSKLLTHHKDHFT 180 Query: 172 PIVTDAVLSVYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNA 231 + +AVL + + +L + +++ S D+ +G +LD + P R++NA Sbjct: 181 KLAVEAVLRLKGSG----NLEAIHVIKKLGGSLADSYLDEGFLLDKK-IGVNQPKRIENA 235 Query: 232 YVLILNVSLEYEKTEVNSGFFYSSA--DQRDKLAASERKFVDAKLKKIIDLKNEVCGMDP 289 +LI N ++ +K ++ F S D K+A E + +K+ + G++ Sbjct: 236 KILIANTGMDTDKIKI----FGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKH--GIN- 288 Query: 290 DKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILG 349 IN++ I +F ++A+ A +ERL LVTGGE ++ + LG Sbjct: 289 ----CFINRQLIYNYPEQLFGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLG 344 Query: 350 FSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDK 409 L+ + IGE+K + + ++CTI+++G+T L + + ++ D L +A +KD Sbjct: 345 SCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDS 404 Query: 410 NIIPGAGAFYIALSRYLRSANMNKLGAK--GKTKTGIEAFAEALLVIPKTLVKNSGFDPL 467 + G G S L + + +L ++ GK +E++A+AL ++P + N+G+D Sbjct: 405 RTVYGGGC-----SEMLMAHAVTQLASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSA 459 Query: 468 DVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNL 527 D++A + A S+ G+D+ G D ++ GI +S++V R + A A + Sbjct: 460 DLVAQLR-----AAHSEGKTTAGLDMKEGTIGDMSVLGITESFQVKRQVLLSAAEAAEVI 514 Query: 528 LLCDELLRA 536 L D +++A Sbjct: 515 LRVDNIIKA 523 >5GW5-q nrPDB Length = 568 Score = 154 bits (389), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 151/577 (26%), Positives = 267/577 (46%), Gaps = 51/577 (8%) Query: 1 MSLQL-LNPKAESLRR--------DAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAG 51 MSL+L NP A ++ D + ++ + L + T++GP G K++V+ G Sbjct: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 Query: 52 NIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQE 111 I +T D +L E+ I P ++ A Q GDGT V+ L GELL + + I Sbjct: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 Query: 112 GVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLT 171 G+ I G+ +ARK ++K LDE + + ND+ LL++ + + +K ++L+ Sbjct: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILS 179 Query: 172 PIVTDAVLSVYDA--QADNL---DLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPT 226 +V++AV V QA + ++ + ++++ S ++T IKG+V + R P+ Sbjct: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFN---REPEGHV 236 Query: 227 RV----KNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKN 282 + K V + L+ TE +A + + E K +DA +K+I D+ Sbjct: 237 KSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGV 296 Query: 283 EVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVED 342 E C I+ G+ ++L ++ IL L+ + + RL V G + Sbjct: 297 E-C---------IVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGA 346 Query: 343 LSPQILGFSGLVYQETIGEEKFTYVTENTD--PKSCTILIKGSTHYALAQTKDAVRDGLR 400 +P+ LG V IG ++ T + ++ TI+++G+T L + A+ DG+ Sbjct: 347 PTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVA 406 Query: 401 AVANVLKDKN--IIPGAGAFYIALSRYLRSANMNKLGAK--GKTKTGIEAFAEALLVIPK 456 AV ++K ++PGAGA I L + + K G + G + I+ FA A V+P+ Sbjct: 407 AVKGLMKPSGGKLLPGAGATEIEL-----ISRITKYGERTPGLLQLAIKQFAVAFEVVPR 461 Query: 457 TLVKNSGFDPLDVLA---MVEDELDDAQDSDETRYVGVDLNIGDS----CDPTIEGIWDS 509 TL + +G D +VL + + + Y GVD++ G+S D E I+D Sbjct: 462 TLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDID-GESDEGVKDIREENIYDM 520 Query: 510 YRVLRNAITGATGIASNLLLCDELLRAGRSTLKETPQ 546 + AI AT A+ +L D+++ A ++ PQ Sbjct: 521 LATKKFAINVATEAATTVLSIDQIIMAKKAGGPRAPQ 557 >4V8R-AG nrPDB Length = 590 Score = 142 bits (358), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 103/366 (28%), Positives = 186/366 (50%), Gaps = 25/366 (6%) Query: 22 NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAA 81 N+T+A+ + V+ T LGPK LKML+D G + LT DG +L E+ + P A + + Sbjct: 24 NITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSR 83 Query: 82 AQDEITGDGTTTVVCLVGELLRQ-AHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISK 140 QDE GDGTTTV+ L GE+L Q A I++ +HP II + A ++++ + + +SK Sbjct: 84 TQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQ--VSK 141 Query: 141 -TNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQAD------NLDLHM 193 ++ ND + ++ ++S+ TK +E + + DAV +V N ++ + Sbjct: 142 PVDVEND-AAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDI 200 Query: 194 VEIMQMQHLSPK---DTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSG 250 ++++ + D+ +KG++L+ HP M ++N V++L+ LEY+K E + Sbjct: 201 KRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTN 260 Query: 251 FFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFA 310 + +++ E + V ++I+ ++ ++I +KG+ ++ Sbjct: 261 IEIEKEEDWNRILQIEEEQVQLMCEQILAVRPT----------LVITEKGVSDLAQHYLL 310 Query: 311 KHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFS-GLVYQETIGEEKFTYVTE 369 K LRR K+ + R+ VTG N VEDL +G + GL E IG+E F+++ Sbjct: 311 KGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDN 370 Query: 370 NTDPKS 375 +P S Sbjct: 371 CKEPGS 376 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 47/170 (27%), Positives = 84/170 (49%), Gaps = 18/170 (10%) Query: 374 KSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNK 433 K+CTI+++G + L + ++D + NV+ ++ PG GA +A+S K Sbjct: 431 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSV--------K 482 Query: 434 LGAKGKTKTGI-----EAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRY 488 L K K GI +A A+A+ IP+TL++N+G DP+ +L+ + A+ + Sbjct: 483 LAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR-----AKHAQGNFT 537 Query: 489 VGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 G+D + G D GIW+ + + ++ A A LL D+++ R Sbjct: 538 TGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVR 587 >5X9V-A nrPDB Length = 521 Score = 132 bits (333), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 137/539 (25%), Positives = 245/539 (45%), Gaps = 50/539 (9%) Query: 7 NPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEM 66 N E R AL N + + L V+ +LGPKG MLVD G + +T DG +LT M Sbjct: 5 NQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLM 64 Query: 67 QIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIAR 126 Q P A ++ A AQ+ GDGTTT L G L+ + I +GV + G A Sbjct: 65 DAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRAL 124 Query: 127 KESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQA 186 ++ + + I ++++DR LL A K+ E + I+ DA + D Sbjct: 125 NHALFLIRKNAIKVGSITDDR--LLAAA------KIAGRGDERVAAILRDAAAMLEDKLQ 176 Query: 187 DN----LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEY 242 D DL + ++ DTT I G+V++ + +++ +L+L+ L Sbjct: 177 DPGFKLADLVLAKV-------GADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYP 229 Query: 243 EKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGID 302 E+ E + + +Q K +K LKK+ +L + +I+ +GI Sbjct: 230 EEVEEEALASEAGFEQYLK----NQKIFQENLKKLKELGVK----------LILLTRGIS 275 Query: 303 PMSLDVFAKHNILALRRAKRRNMERLQLVTGGEA------QNSVEDLSPQILGFSGLVYQ 356 ++ + ++ I+ + R ++ ++R+ TG A VE+L ++LG++ + Sbjct: 276 DIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQ-KMLGYARTCFY 334 Query: 357 ETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAG 416 ++ FT + + T+LI +T + + + +D + A + ++PG G Sbjct: 335 DS--RLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRS-GVLPGGG 391 Query: 417 AFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDE 476 AF++ LSR + S N+L G G+ AF+EAL V + + +N+GF+ L+ L + Sbjct: 392 AFFLYLSREVESLK-NRL--PGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLG----D 444 Query: 477 LDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLR 535 L Q +G+D G+ D G+ D V+ A+ A+ +A +LL + +++ Sbjct: 445 LMTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTIIK 503 >4B2T-Q nrPDB Length = 548 Score = 122 bits (306), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 125/530 (23%), Positives = 243/530 (45%), Gaps = 37/530 (6%) Query: 16 DAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVL 75 + A+ N+ + + L T GP G KM+++ + +T D +L E+++Q P A + Sbjct: 26 EEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKM 85 Query: 76 IARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDE 135 I A+ Q++ GDGT V+ G LL A ++ G+ + +G+EIA K++ + L + Sbjct: 86 IVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEGYEIACKKAHEILPD 145 Query: 136 FKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVE 195 D + + + +S+++K + L ++ A +S++ + + ++ + Sbjct: 146 LVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEV-FLAKLIAQACVSIF-PDSGHFNVDNIR 203 Query: 196 IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSS 255 + ++ ++ + G+V D+ T VK+A + + + + TE S Sbjct: 204 VCKILGSGVHSSSVLHGMVFKK-ETEGDV-TSVKDAKIAVYSCPFDGMITETKGTVLIKS 261 Query: 256 ADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNIL 315 A++ + E +DA++K I D V++ + M+L K+NI+ Sbjct: 262 AEELMNFSKGEENLMDAQVKAIADTGAN----------VVVTGGRVADMALHYANKYNIM 311 Query: 316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQIL---GFSGLVYQETIGEEK-FTYVTENT 371 +R + ++ RL G A + L+P +L G VY +G+ + + E Sbjct: 312 LVRLNSKWDLRRLCKTVGATA---LPRLNPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKE 368 Query: 372 DPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANM 431 D TI+++GST + + AV DG+ + +DK ++PG GA I L++ + S Sbjct: 369 DGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGE 428 Query: 432 NKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGV 491 G + I+ FAEA IP+ L +NSG +V++ + A + + VG+ Sbjct: 429 T---CPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLY-----AVHQEGNKNVGL 480 Query: 492 DLNIGDSCDPTIE-----GIWDSYRVLRNAITGATGIASNLLLCDELLRA 536 D+ ++ P ++ G+ D+Y AI AT A +L D+++ A Sbjct: 481 DI---EAEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMA 527 >1GN1-A nrPDB Length = 178 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 51/181 (28%), Positives = 100/181 (55%), Gaps = 11/181 (6%) Query: 205 KDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAA 264 +D+ ++G++++ HP M +KN +++L+ SLEY+K E + + + ++ Sbjct: 2 EDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQ 61 Query: 265 SERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRN 324 E +++ + II LK PD V+I +KGI ++ + N+ A+RR ++ + Sbjct: 62 MEEEYIHQLCEDIIQLK-------PD---VVITEKGISDLAQHYLMRANVTAIRRVRKTD 111 Query: 325 MERLQLVTGGEAQNSVEDLSPQILGF-SGLVYQETIGEEKFTYVTENTDPKSCTILIKGS 383 R+ G + E+L +G +GL+ + IG+E FT++T+ DPK+CTIL++G+ Sbjct: 112 NNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGA 171 Query: 384 T 384 + Sbjct: 172 S 172 >1ASS-A nrPDB Length = 159 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 49/157 (31%), Positives = 81/157 (51%), Gaps = 12/157 (7%) Query: 212 GLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQ-RDKLAASERKFV 270 G+V+D H MP VKNA + +++ +LE +KTE+ + S + +D L F Sbjct: 3 GIVIDKEKVHSKMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTF- 61 Query: 271 DAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQL 330 K V + V++ QKGID ++ AK I A+RR K+ +ME+L Sbjct: 62 ----------KQMVEKIKKSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAK 111 Query: 331 VTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYV 367 TG + ++DL+P +LG + V + IG+++ T+V Sbjct: 112 ATGAKIVTDLDDLTPSVLGEAETVEERKIGDDRMTFV 148 >1E0R-B nrPDB Length = 159 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 84/159 (52%), Gaps = 10/159 (6%) Query: 210 IKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKF 269 + G+++D HP MP VK+A + +L+ LE +K E ++ K A E Sbjct: 1 MNGIIVDKEKVHPGMPDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENM 60 Query: 270 VDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQ 329 L++++D K + G + V+I QKGID M+ ++ I A+RR K+ +M++L Sbjct: 61 ----LREMVD-KIKSVGAN-----VVITQKGIDDMAQHYLSRAGIYAVRRVKKSDMDKLA 110 Query: 330 LVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVT 368 TG ++++++S LG + V Q +GE+ T+VT Sbjct: 111 KATGASIVSTIDEISSSDLGTAERVEQVKVGEDYMTFVT 149 >1IOK-A nrPDB Length = 545 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 50/199 (25%), Positives = 96/199 (48%), Gaps = 18/199 (9%) Query: 15 RDAALK-VNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQI----Q 69 RD LK VN+ L ++ LGPKG ++ G ++TKDG + E+++ + Sbjct: 13 RDRMLKGVNI-----LADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELSDKFE 67 Query: 70 SPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKES 129 + A ++ A+ ++ GDGTTT L ++R+ + + G++P + G ++A + Sbjct: 68 NMGAQMVREVASRTNDEAGDGTTTATVLAQAIVREGLKAVAAGMNPMDLKRGIDVA---T 124 Query: 130 MKFLDEFKISKTNLSNDREFLLQVARSSLLTK--VDADLTEVLTPIVTDAVLSVYDAQAD 187 K ++ K S ND + QV S + + + E + + + V++V + + Sbjct: 125 AKVVEAIK-SAARPVNDSSEVAQVGTISANGESFIGQQIAEAMQRVGNEGVITVEENKGM 183 Query: 188 NLDLHMVEIMQMQ--HLSP 204 ++ +VE MQ +LSP Sbjct: 184 ETEVEVVEGMQFDRGYLSP 202 >5DA8-A nrPDB Length = 545 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/194 (26%), Positives = 90/194 (46%), Gaps = 15/194 (7%) Query: 19 LKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPT----AV 74 LKV V + L + ++ LGP G ++ G TKDG + E+++ P A Sbjct: 16 LKVGV---DKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQ 72 Query: 75 LIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLD 134 ++ A+ ++ GDGTTT L + R+ + + G P + G + A KE + Sbjct: 73 MVREVASKTSDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKE---VVA 129 Query: 135 EFKISKTNLSNDREFLLQVARSSLLT--KVDADLTEVLTPIVTDAVLSVYDAQADNLDLH 192 E + ++S +E + QV S ++ + E + + D V++V +A+ +L Sbjct: 130 ELRNISRSISGKKE-IAQVGTISANNDPEIGELIAEAMDKVGKDGVITVEEAKGMETELK 188 Query: 193 MVEIMQMQ--HLSP 204 +VE MQ +LSP Sbjct: 189 VVEGMQFDRGYLSP 202 >4V4O-A nrPDB Length = 543 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 52/232 (22%), Positives = 112/232 (48%), Gaps = 25/232 (10%) Query: 11 ESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQ- 69 E+ RR VN + + ++ LGP+G +L G+ +TKDG + E++++ Sbjct: 9 EAARRALERGVNAVA-----NAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELED 63 Query: 70 ---SPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIAR 126 + A L+ A+ +++ GDGTTT L ++R+ + + G +P + G E A Sbjct: 64 HLENIGAQLLKEVASKTNDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAV 123 Query: 127 KESMKFLDEFKISKTNLSNDREFLLQVAR-SSLLTKVDADLTEVLTPIVTDAVLSVYDAQ 185 + +++ + I DR+ + +VA S+ +V + + + + + +++V +++ Sbjct: 124 EAAVEKIKALAIP----VEDRKAIEEVATISANDPEVGKLIADAMEKVGKEGIITVEESK 179 Query: 186 ADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPD-MPTRVKNAYVLIL 236 + +L VE Q F KG + + +P+ M +++A++LI+ Sbjct: 180 SLETELKFVEGYQ----------FDKGYISPYFVTNPETMEAVLEDAFILIV 221 >1SJP-A nrPDB Length = 504 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/197 (22%), Positives = 89/197 (45%), Gaps = 28/197 (14%) Query: 51 GNIKLTKDGKVLLTEMQIQSP----TAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAH 106 G +T DG + E++++ P A L+ A D++ GDGTTT L L+R+ Sbjct: 2 GAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGL 61 Query: 107 RFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLL--QVARSSLLTKVDA 164 R + G +P + G E A + K+++T L +E Q+A ++ ++ D Sbjct: 62 RNVAAGANPLGLKRGIEKAVE---------KVTETLLKGAKEVETKEQIAATAAISAGDQ 112 Query: 165 D----LTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGR 220 + E + + + V++V ++ L L + E M+ D +I G + R Sbjct: 113 SIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRF------DKGYISGYFVTDPER 166 Query: 221 HPDMPTRVKNAYVLILN 237 + +++ Y+L+++ Sbjct: 167 QEAV---LEDPYILLVS 180 >4AAR-A nrPDB Length = 548 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 44/184 (23%), Positives = 84/184 (45%), Gaps = 12/184 (6%) Query: 29 LQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSP----TAVLIARAAAAQD 84 L ++ LGPKG +L G +TKDG + E++++ A ++ A+ + Sbjct: 23 LADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKAN 82 Query: 85 EITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLS 144 + GDGTTT L ++ + + + G++P + G + A +++ L + Sbjct: 83 DAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKALSVP----C 138 Query: 145 NDREFLLQVARSSLLT--KVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQMQ-- 200 +D + + QV S + V + E + + + V++V D +L +VE MQ Sbjct: 139 SDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRG 198 Query: 201 HLSP 204 +LSP Sbjct: 199 YLSP 202 >4PJ1-A nrPDB Length = 558 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 47/190 (24%), Positives = 84/190 (44%), Gaps = 24/190 (12%) Query: 29 LQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSP----TAVLIARAAAAQD 84 L + +GPKG ++ G+ K+TKDG + + ++ A L+ A + Sbjct: 49 LADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTN 108 Query: 85 EITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLS 144 E GDGTTT L + ++ I +G +P I G +A + E K ++ Sbjct: 109 EEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVD---AVIAELKKQSKPVT 165 Query: 145 NDREFLLQVARSSLLTKVDADLTEVLTPIVTDA--------VLSVYDAQADNLDLHMVEI 196 E + QVA + A+ + + I++DA V++V D + N +L ++E Sbjct: 166 TPEE-IAQVAT------ISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEG 218 Query: 197 MQMQ--HLSP 204 M+ ++SP Sbjct: 219 MKFDRGYISP 228 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 43/157 (27%), Positives = 70/157 (44%), Gaps = 19/157 (12%) Query: 380 IKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFY--IALSRYLRSANMNKLGAK 437 + G++ + + KD V D L A +++ ++ G A I L AN ++ Sbjct: 408 VGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQ---- 463 Query: 438 GKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGD 497 K GIE L + T+ KN+G + ++ + Q S E VG D GD Sbjct: 464 ---KIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKI------MQSSSE---VGYDAMAGD 511 Query: 498 SCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELL 534 + +GI D +V+R A+ A G+AS LL E++ Sbjct: 512 FVNMVEKGIIDPTKVVRTALLDAAGVAS-LLTTAEVV 547 >5OGZ-A nrPDB Length = 456 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 39/80 (48%), Gaps = 8/80 (10%) Query: 61 VLLTEMQIQSPTAVLIARAAAAQDEITGDGT---TTVVCLVGELLRQAHRFIQEGVHPRI 117 ++L + P V+ AA +DEI +G T + + + L QAHR IQ+GV+ + Sbjct: 339 LMLLDRDYGKPNIVISENGAAFKDEIGSNGKIEDTKRIQYLKDYLTQAHRAIQDGVNLKA 398 Query: 118 -----ITDGFEIARKESMKF 132 + D FE A + +F Sbjct: 399 YYLWSLLDNFEWAYGYNKRF 418 >5CDI-A nrPDB Length = 552 Score = 35.0 bits (79), Expect = 0.091, Method: Compositional matrix adjust. Identities = 35/120 (29%), Positives = 57/120 (47%), Gaps = 4/120 (3%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPT----A 73 ALK + L +V+ +GPKG +L G K+ DG + E+++ P A Sbjct: 13 ALKRMQAGVDKLATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPVENIGA 72 Query: 74 VLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFL 133 L+ +AAA ++ GDGTTT L + + + + G +P + G E +E +K L Sbjct: 73 TLVRQAAARTNDTAGDGTTTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTVQELVKEL 132 >5NNN-A nrPDB Length = 315 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 25/43 (58%) Query: 327 RLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTE 369 R QLV G+ E L+P+ILG + ++Y + +E+F + E Sbjct: 207 RQQLVDAGQLLCESEALTPEILGRTDVLYCTRVQKERFPSLAE 249 >6NHX-A nrPDB Length = 307 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 21/45 (46%), Gaps = 9/45 (20%) Query: 502 TIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKETPQ 546 EG+WD YR+L A GA + S R+GR E PQ Sbjct: 27 AFEGMWDGYRLLVEADHGAVRLRS---------RSGRDVTAEYPQ 62 >3H8L-A nrPDB Length = 409 Score = 29.3 bits (64), Expect = 5.0, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 30/73 (41%), Gaps = 4/73 (5%) Query: 351 SGLVYQE----TIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVL 406 S +VY ++ EE++ YV T L+KG Y + + LR Sbjct: 85 SSMVYYTKPDGSMAEEEYDYVIVGIGAHLATELVKGWDKYGYSVCEPEFATKLREKLESF 144 Query: 407 KDKNIIPGAGAFY 419 + NI G+G FY Sbjct: 145 QGGNIAIGSGPFY 157 >6NOD-A nrPDB Length = 356 Score = 28.5 bits (62), Expect = 8.0, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 31/59 (52%), Gaps = 4/59 (6%) Query: 337 QNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAV 395 Q ++E +SPQ + F +V +T+ E T + DP C ++ + H + +QTK + Sbjct: 153 QKAIEKVSPQYVQF--IV--DTLLESSNTIYEMSVDPYGCRVVQRCLEHCSPSQTKPVI 207 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5GW5-z nrPDB 624 e-179 4XCG-B nrPDB 592 e-169 3J1E-A nrPDB 589 e-169 1A6E-A nrPDB 580 e-166 1Q3S-A nrPDB 579 e-165 3J1C-A nrPDB 575 e-164 5UYZ-A nrPDB 567 e-162 1A6D-B nrPDB 566 e-162 4XCI-A nrPDB 564 e-161 4B2T-H nrPDB 561 e-160 4B2T-Z nrPDB 561 e-160 4B2T-G nrPDB 559 e-159 3RUW-A nrPDB 555 e-158 4V8R-AE nrPDB 550 e-157 5GW4-h nrPDB 534 e-152 5GW5-g nrPDB 533 e-152 4B2T-A nrPDB 533 e-151 3AQ1-B nrPDB 531 e-151 4B2T-D nrPDB 530 e-151 3IYF-A nrPDB 526 e-149 4V94-A nrPDB 508 e-144 4V8R-AB nrPDB 504 e-143 5GW4-d nrPDB 497 e-141 4B2T-B nrPDB 489 e-138 4B2T-Q nrPDB 482 e-136 5GW5-q nrPDB 479 e-135 4V8R-AG nrPDB 422 e-118 5X9V-A nrPDB 414 e-116 4V4O-A nrPDB 231 7e-61 1IOK-A nrPDB 211 7e-55 4AAR-A nrPDB 201 1e-51 4PJ1-A nrPDB 196 1e-50 1GN1-A nrPDB 196 3e-50 5DA8-A nrPDB 185 3e-47 1E0R-B nrPDB 174 7e-44 1SJP-A nrPDB 173 2e-43 1ASS-A nrPDB 171 8e-43 Sequences not found previously or not previously below threshold: 5CDI-A nrPDB 159 3e-39 3LXD-A nrPDB 43 3e-04 3E0V-A nrPDB 37 0.025 2GJN-A nrPDB 37 0.025 3FTB-A nrPDB 35 0.12 2IOU-G nrPDB 32 0.60 6ESQ-A nrPDB 32 0.61 1Z2N-X nrPDB 31 1.5 1UF2-K nrPDB 31 1.7 3PLN-A nrPDB 30 2.0 3L6X-A nrPDB 30 2.1 3MY9-A nrPDB 30 2.8 1S5J-A nrPDB 30 3.4 2GF2-A nrPDB 29 5.9 1V72-A nrPDB 29 6.4 3I4E-A nrPDB 28 7.3 4KRZ-A nrPDB 28 8.3 3GEE-A nrPDB 28 9.7 >5GW5-z nrPDB Length = 546 Score = 624 bits (1609), Expect = e-179, Method: Composition-based stats. Identities = 546/546 (100%), Positives = 546/546 (100%) Query: 1 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGK 60 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGK Sbjct: 1 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGK 60 Query: 61 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD 120 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD Sbjct: 61 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD 120 Query: 121 GFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS 180 GFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS Sbjct: 121 GFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS 180 Query: 181 VYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSL 240 VYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSL Sbjct: 181 VYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSL 240 Query: 241 EYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKG 300 EYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKG Sbjct: 241 EYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKG 300 Query: 301 IDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG 360 IDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG Sbjct: 301 IDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG 360 Query: 361 EEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYI 420 EEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYI Sbjct: 361 EEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYI 420 Query: 421 ALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDA 480 ALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDA Sbjct: 421 ALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDA 480 Query: 481 QDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRST 540 QDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRST Sbjct: 481 QDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRST 540 Query: 541 LKETPQ 546 LKETPQ Sbjct: 541 LKETPQ 546 >4XCG-B nrPDB Length = 557 Score = 592 bits (1526), Expect = e-169, Method: Composition-based stats. Identities = 176/545 (32%), Positives = 294/545 (53%), Gaps = 21/545 (3%) Query: 1 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGK 60 + + +L + AL+ N+ + + ++ L++ GP+G KMLVD G+I +T DG Sbjct: 16 IPVIILKEGSSRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGA 75 Query: 61 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD 120 +L +M +Q PT L+ + A QDE T DGT T V L GEL ++A + + +HP II Sbjct: 76 TILDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVS 135 Query: 121 GFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS 180 G++ A + ++K + E I++ ND + L +VA +SL +K A E L +V AV Sbjct: 136 GYKKAEEIALKTIQE--IAQPVTINDTDVLRKVALTSLGSKAVAGAREYLADLVVKAVAQ 193 Query: 181 VYDAQADN--LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNV 238 V + + D +DL V+I++ S DT + G+V+D HP MP R++NA + +L+ Sbjct: 194 VAELRGDKWYVDLDNVQIVKKHGGSVNDTQLVYGIVVDKEVVHPGMPKRIENAKIALLDA 253 Query: 239 SLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQ 298 SLE EK E+++ + Q K E + K+ KI V+I Q Sbjct: 254 SLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIA----------ATGANVVICQ 303 Query: 299 KGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQET 358 KGID ++ AK ILA+RRAK+ ++E+L TGG +++++L+ Q LG++ LV + Sbjct: 304 KGIDEVAQHYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVEERK 363 Query: 359 IGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAF 418 +GE+K +V +PKS +ILI+G + +T+ A+RD L VA+V++D + G GA Sbjct: 364 VGEDKMVFVEGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAV 423 Query: 419 YIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELD 478 I +++ LR GK + IEA+A A+ + L +N+G DP+D L + Sbjct: 424 EIEIAKRLRKYA---PQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRS--- 477 Query: 479 DAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 +++ ++ G++L G+ D G+ + V NA+ AT + +L D+++ AG+ Sbjct: 478 -LHENETNKWYGLNLFTGNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGK 536 Query: 539 STLKE 543 + E Sbjct: 537 KSGSE 541 >3J1E-A nrPDB Length = 553 Score = 589 bits (1519), Expect = e-169, Method: Composition-based stats. Identities = 176/546 (32%), Positives = 299/546 (54%), Gaps = 21/546 (3%) Query: 1 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGK 60 + + +L + A++ N+ + + ++ L++ GP+G KMLVD G+I +T DG Sbjct: 14 IPVIILKEGSSRTYGKEAVRANIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITITNDGA 73 Query: 61 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD 120 +L +M +Q P A L+ + A QDE T DGT T V GEL+++A + + VHP II Sbjct: 74 TILDKMDLQHPAAKLLVQIAKGQDEETADGTKTAVIFSGELVKKAEDLLYKDVHPTIIIS 133 Query: 121 GFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS 180 G++ A + +++ + E +T ND + L ++A +SL +K A E + IV AV Sbjct: 134 GYKKAEEVALQTIQELA--QTVSINDTDLLRKIAMTSLSSKAVAGAREYIADIVVKAVTQ 191 Query: 181 VYDAQADN--LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNV 238 V + + D +DL ++I++ S DT + G+V+D HP MP R++NA + +++ Sbjct: 192 VAELRGDKWYVDLDNIQIVKKAGGSINDTQLVYGIVVDKEVVHPGMPKRLENAKIALIDA 251 Query: 239 SLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQ 298 SLE EK E+++ + Q K E + K+ KI+ VII Q Sbjct: 252 SLEVEKPELDAEIRINDPTQMQKFLDEEENLIKEKVDKIL----------ATGANVIICQ 301 Query: 299 KGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQET 358 KGID ++ AK +LA+RRAK+ ++E+L TGG ++++++S Q LG++ L+ + Sbjct: 302 KGIDEVAQSYLAKKGVLAVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGYASLIEERK 361 Query: 359 IGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAF 418 +GE+K +V +PKS +ILI+G + +T+ A+RD L VA+V+KD I G GA Sbjct: 362 VGEDKMVFVEGAKNPKSISILIRGGLERLVDETERALRDALGTVADVIKDGRAIAGGGAV 421 Query: 419 YIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELD 478 I +++ LR GK + +EA+A AL + L++N+GFDP+D+L + Sbjct: 422 EIEIAKKLRKYA---PQVGGKEQLAVEAYANALESLVSILIENAGFDPIDLLMKLRS--- 475 Query: 479 DAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 +++ ++ G+DL G D +G+ + V NAI AT A+ +L D+++ AG+ Sbjct: 476 -THENENNKWYGIDLYAGQPVDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVSAGK 534 Query: 539 STLKET 544 + E+ Sbjct: 535 KSGGES 540 >1A6E-A nrPDB Length = 545 Score = 580 bits (1494), Expect = e-166, Method: Composition-based stats. Identities = 171/540 (31%), Positives = 285/540 (52%), Gaps = 24/540 (4%) Query: 5 LLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLT 64 +L + + A + N+ +A+ + + T LGPKG KMLVD G+I ++ DG +L Sbjct: 10 VLKEGTQREQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISNDGATILK 69 Query: 65 EMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEI 124 EM ++ PTA +I + AQD GDGTTT V L GELL+QA + +GVHP +I++G+ + Sbjct: 70 EMDVEHPTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVISNGYRL 129 Query: 125 ARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDA 184 A E+ K +DE T+ + L ++A ++L K + L +V AV +V + Sbjct: 130 AVNEARKIIDEIAEKSTDDA----TLRKIALTALSGKNTGLSNDFLADLVVKAVNAVAEV 185 Query: 185 QADN--LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEY 242 + +D +++ + S DT FI G+V+D H MP VKNA + +++ +LE Sbjct: 186 RDGKTIVDTANIKVDKKNGGSVNDTQFISGIVIDKEKVHSKMPDVVKNAKIALIDSALEI 245 Query: 243 EKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGID 302 +KTE+ + S + E ++KI V++ QKGID Sbjct: 246 KKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKK----------SGANVVLCQKGID 295 Query: 303 PMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEE 362 ++ AK I A+RR K+ +ME+L TG + ++DL+P +LG + V + IG++ Sbjct: 296 DVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVEERKIGDD 355 Query: 363 KFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIAL 422 + T+V +PK+ +ILI+G T + +++ + A+ D +R VA +D + G GA L Sbjct: 356 RMTFVMGCKNPKAVSILIRGGTDHVVSEVERALNDAIRVVAITKEDGKFLWGGGAVEAEL 415 Query: 423 SRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQD 482 + L + G+ + IEAFA+AL +IP+TL +N+G DP++ L ++ A D Sbjct: 416 AMRLAKYANS---VGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLK-----ADD 467 Query: 483 SDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLK 542 VGVDL+ D +G+ D RV +A+ A +A+ +L D+++ + +ST Sbjct: 468 EKGRISVGVDLDNNGVGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASKKSTPP 527 >1Q3S-A nrPDB Length = 548 Score = 579 bits (1493), Expect = e-165, Method: Composition-based stats. Identities = 164/522 (31%), Positives = 278/522 (53%), Gaps = 22/522 (4%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 A ++N+ +A + + T LGPKG KMLVD G+I +T D +L ++ +Q P A ++ Sbjct: 24 AQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDCATILDKIDLQHPAAKMMV 83 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 A QD+ GDGTTT V + GELLR+A + + +HP II G+ +A +++ + LDE Sbjct: 84 EVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSIIIKGYALAAEKAQEILDEIA 143 Query: 138 ISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADN--LDLHMVE 195 I +D E LL++A +S+ K E+L + +AV V + + +DL ++ Sbjct: 144 I--RVDPDDEETLLKIAATSITGKNAESHKELLAKLAVEAVKQVAEKKDGKYVVDLDNIK 201 Query: 196 IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSS 255 + +++ ++G+V+D HP MP RV+NA + ++N +LE +KTE ++ +S Sbjct: 202 FEKKAGEGVEESELVRGVVIDKEVVHPRMPKRVENAKIALINEALEVKKTETDAKINITS 261 Query: 256 ADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNIL 315 DQ E K + + I V+ QKGID ++ AK+ I+ Sbjct: 262 PDQLMSFLEQEEKMLKDMVDHIAQ----------TGANVVFVQKGIDDLAQHYLAKYGIM 311 Query: 316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKS 375 A+RR K+ +ME+L TG + +V+DL+P+ LG++ +V + + E +V +PK+ Sbjct: 312 AVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAGENMIFVEGCKNPKA 371 Query: 376 CTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLG 435 TILI+G T + + + + A+ D ++ V +V++D ++P GA I L+ L Sbjct: 372 VTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIELAIRLDEYAKQ--- 428 Query: 436 AKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNI 495 GK IE FA+AL +IPKTL +N+G D +++L V + + +G+D+ Sbjct: 429 VGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVIS-----EHKNRGLGIGIDVFE 483 Query: 496 GDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAG 537 G D +GI + RV + AI A+ A +L D+++ A Sbjct: 484 GKPADMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDVIAAK 525 >3J1C-A nrPDB Length = 563 Score = 575 bits (1483), Expect = e-164, Method: Composition-based stats. Identities = 172/546 (31%), Positives = 290/546 (53%), Gaps = 28/546 (5%) Query: 3 LQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVL 62 + L ALK N+ +A L +L ++LGPKG KML+D G++ +T DG + Sbjct: 7 VLLFKEGTSRNSGRDALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATI 66 Query: 63 LTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGF 122 + EM+IQ P A L+ AA AQD GDGTT+ V L G L +A + + +HP II +GF Sbjct: 67 VKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHPTIIIEGF 126 Query: 123 EIARKESMKFLDEFK----ISKTNLSNDREFLLQVARSSLLTKVDADLTE--VLTPIVTD 176 + A +S++ L + +S N + R+ L ++ +++ +K A+ E + IV D Sbjct: 127 KKAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNKIMDIVID 186 Query: 177 AVLSVYDAQAD---NLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYV 233 AV +V + D N+ L +++I + + + +D+ I+G+VLD H MP RV+ A + Sbjct: 187 AVTTVAEPLPDGGYNVSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVVHAGMPRRVEKAKI 246 Query: 234 LILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGF 293 +L+ SLE EK E+++ +S DQ E K++ + K+ + Sbjct: 247 AVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIG----------AN 296 Query: 294 VIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGL 353 V+I QKGID ++ AK ILA+RR KR ++E+L+ G +S++D +P+ LG++ L Sbjct: 297 VVICQKGIDDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAEL 356 Query: 354 VYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIP 413 V + +G +K ++ +PK+ IL++GS AL + + ++ D L ++ N+L + I+P Sbjct: 357 VEERKVGNDKMVFIEGAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILMEPYIVP 416 Query: 414 GAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMV 473 G GA + LS LR + GK + IEA+A+AL IP L + +G +P+ L + Sbjct: 417 GGGAIELELSARLREYARS---VGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDL 473 Query: 474 EDELDDAQDSDETRYVGVDLNIGDSCDPTIE-GIWDSYRVLRNAITGATGIASNLLLCDE 532 A+ + GVD+ G D + + RV R + AT A++++ D+ Sbjct: 474 R-----ARHAKGLTNCGVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDD 528 Query: 533 LLRAGR 538 L+ A + Sbjct: 529 LIAASQ 534 >5UYZ-A nrPDB Length = 541 Score = 567 bits (1461), Expect = e-162, Method: Composition-based stats. Identities = 139/525 (26%), Positives = 260/525 (49%), Gaps = 19/525 (3%) Query: 17 AALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLI 76 ALK ++ +A+ + + + T+LGP G KM+VD G++ +T DG +L+ M + A L+ Sbjct: 32 EALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLM 91 Query: 77 ARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEF 136 + +QD+ GDGTT VV L G LL +A + + G+HP I DG+E A + +++ LD+ Sbjct: 92 VELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIERLDKI 151 Query: 137 KISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEI 196 S D E L+Q A+++L +KV + I +AVL+V D + ++D ++++ Sbjct: 152 SDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKV 211 Query: 197 MQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSA 256 +DT IKG+++D HP MP +V++A + IL E K + +S Sbjct: 212 EGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSV 271 Query: 257 DQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILA 316 + L E++ + +++I + + I Q G D + + ++N+ A Sbjct: 272 EDYKALQKYEKEKFEEMIQQIKETGANLA----------ICQWGFDDEANHLLLQNNLPA 321 Query: 317 LRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG--EEKFTYVTENTDPK 374 +R +E + + TGG +L+ + LGF+GLV + + G ++K + + + + Sbjct: 322 VRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSR 381 Query: 375 SCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKL 434 + TI I+G + + K ++ D L + N+++D ++ G GA I+ + + Sbjct: 382 AVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADK-- 439 Query: 435 GAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLN 494 + + AFA+AL VIP L +NSG +P+ + V Q + +G+D Sbjct: 440 -CPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRA----RQVKEMNPALGIDCL 494 Query: 495 IGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRS 539 + D + + ++ + I+ AT + +L D++ + G S Sbjct: 495 HKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGES 539 >1A6D-B nrPDB Length = 543 Score = 566 bits (1460), Expect = e-162, Method: Composition-based stats. Identities = 160/533 (30%), Positives = 283/533 (53%), Gaps = 22/533 (4%) Query: 5 LLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLT 64 +L + A+K N+ +A + + + ++LGP+G KMLVD G+I +T DG +L Sbjct: 9 ILKEGTKRESGKDAMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDGVTILK 68 Query: 65 EMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEI 124 EM ++ P A ++ + QD GDGTTT V + G LL+QA I + VHP +I++G+ + Sbjct: 69 EMDVEHPAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTVISEGYRM 128 Query: 125 ARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDA 184 A +E+ + +DE IS ++++ LL++A++SL +K + + L I +AV SV + Sbjct: 129 ASEEAKRVIDE--ISTKIGADEKALLLKMAQTSLNSKSASVAKDKLAEISYEAVKSVAEL 186 Query: 185 QADN--LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEY 242 + +D +++++ Q + DT I G+++D HP MP VK+A + +L+ LE Sbjct: 187 RDGKYYVDFDNIQVVKKQGGAIDDTQLINGIIVDKEKVHPGMPDVVKDAKIALLDAPLEI 246 Query: 243 EKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGID 302 +K E ++ K A E + + KI + V+I QKGID Sbjct: 247 KKPEFDTNLRIEDPSMIQKFLAQEENMLREMVDKIKSVG----------ANVVITQKGID 296 Query: 303 PMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEE 362 M+ ++ I A+RR K+ +M++L TG ++++++S LG + V Q +GE+ Sbjct: 297 DMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVGED 356 Query: 363 KFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIAL 422 T+VT +PK+ +IL++G T + + + + ++ D L VA+ L+D G GA + Sbjct: 357 YMTFVTGCKNPKAVSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAAEI 416 Query: 423 SRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQD 482 + LRS G+ + IE FA+A+ IP+ L +N+G DP+D+L + A+ Sbjct: 417 AFRLRSYAQK---IGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLR-----AEH 468 Query: 483 SDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLR 535 + + G+++ G+ D G+ + RV + AI AT A +L D+++ Sbjct: 469 AKGNKTYGINVFTGEIEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVIA 521 >4XCI-A nrPDB Length = 559 Score = 564 bits (1454), Expect = e-161, Method: Composition-based stats. Identities = 171/544 (31%), Positives = 289/544 (53%), Gaps = 28/544 (5%) Query: 3 LQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVL 62 + LL AL+ N+ +A+ L +L ++LGPKG KML+D G++ +T DG + Sbjct: 5 VLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATI 64 Query: 63 LTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGF 122 + +M+IQ P A L+ AA AQD GDGTT+ V L G LL +A + + +HP II +G+ Sbjct: 65 VKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGY 124 Query: 123 EIARKESMKFLDEF----KISKTNLSNDREFLLQVARSSLLTKVDADLTE--VLTPIVTD 176 + A ++++ L + I N S R+ L ++A ++L +K A+ E + +V D Sbjct: 125 KKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIIDMVID 184 Query: 177 AVLSVYDAQAD---NLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYV 233 A+++V + + N+ L +++I + + S +D+ +KGLVLD HP MP RV A + Sbjct: 185 AIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVTKAKI 244 Query: 234 LILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGF 293 +L+ +LE EK E+++ +S +Q E K++ + K+ + Sbjct: 245 AVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIG----------AN 294 Query: 294 VIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGL 353 V+I QKGID ++ AK ILA+RR KR ++E+L+ G +S++D +P+ LG++ L Sbjct: 295 VVICQKGIDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAEL 354 Query: 354 VYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIP 413 V + +G +K ++ + K+ IL++GS AL + + ++ D L A+ N+L + I+P Sbjct: 355 VEERRVGNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILP 414 Query: 414 GAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMV 473 G GA + L+ LR + GK + IEAFA+AL IP L + +G + + L + Sbjct: 415 GGGAIELELAMKLREYARS---VGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDL 471 Query: 474 EDELDDAQDSDETRYVGVDLNIGDSCDPTIE-GIWDSYRVLRNAITGATGIASNLLLCDE 532 A+ + GVD+ G D I + RV + AT A+ +L D+ Sbjct: 472 R-----ARHAKGLSNTGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDD 526 Query: 533 LLRA 536 L+ A Sbjct: 527 LIAA 530 >4B2T-H nrPDB Length = 543 Score = 561 bits (1447), Expect = e-160, Method: Composition-based stats. Identities = 143/548 (26%), Positives = 266/548 (48%), Gaps = 27/548 (4%) Query: 3 LQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVL 62 + LL +S + L N+++ + + + T LGP+G K++VDG G ++ DG + Sbjct: 6 VILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATI 65 Query: 63 LTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGF 122 L + + P A + A +QD GDGTT+V L E L+Q +++EG+HP+II F Sbjct: 66 LKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAF 125 Query: 123 EIARKESMKFLDEFK--ISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS 180 A + ++ + E + K + R+ L + A ++L +K+ + +V DAV+ Sbjct: 126 RTATQLAVNKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMM 185 Query: 181 VYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDM---PTRVKNAYVLILN 237 + D L L M+ I ++Q + +++ + G+ + P + N + +LN Sbjct: 186 LDDL----LQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNPMIALLN 241 Query: 238 VSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIIN 297 V LE + + N+ + + + +E + KL+KI V+++ Sbjct: 242 VELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKI----------HHSGAKVVLS 291 Query: 298 QKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQE 357 + I ++ FA ++ R +++R + GG Q SV LS +LG + + Sbjct: 292 KLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEET 351 Query: 358 TIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGA 417 IG E++ + T K+CTI+++G + +T+ ++ D + V +K+ +++ G GA Sbjct: 352 QIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGA 411 Query: 418 FYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDEL 477 + LS+YLR + GK + I A+A+AL +IP+ L N+GFD ++L + Sbjct: 412 IEMELSKYLRDYSRT---IPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLR--- 465 Query: 478 DDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAG 537 A+ + + GVD+N D D +W+ V NA+T A+ A ++ DE ++ Sbjct: 466 --ARHAQGGMWYGVDINTEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNP 523 Query: 538 RSTLKETP 545 RST+ +P Sbjct: 524 RSTVDASP 531 >4B2T-Z nrPDB Length = 531 Score = 561 bits (1446), Expect = e-160, Method: Composition-based stats. Identities = 309/541 (57%), Positives = 405/541 (74%), Gaps = 13/541 (2%) Query: 2 SLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKV 61 +++ LNPKAE R AAL VN+++A GLQ VL TNLGPKGT+KMLV GAG+IKLTKDG V Sbjct: 3 AVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNV 62 Query: 62 LLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDG 121 LL EMQIQ PTA LIA+ A AQD+ITGDGTT+ V ++GELL+QA +I EG+HPRIIT+G Sbjct: 63 LLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEG 122 Query: 122 FEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSV 181 FE A++++++FL++ K+SK DRE L+ VAR+SL TKV A+L +VLT V D++L++ Sbjct: 123 FEAAKEKALQFLEQVKVSK---EMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAI 179 Query: 182 YDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLE 241 Q + +DL MVEIM+M+H S DT+ I+GLVLDHG RHPDM RV++AY+L NVSLE Sbjct: 180 K-KQDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLE 238 Query: 242 YEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGI 301 YEKTEVNSGFFY SA++R+KL +ERKF++ ++KKII+LK +VCG D DKGFV+INQKGI Sbjct: 239 YEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCG-DSDKGFVVINQKGI 297 Query: 302 DPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGE 361 DP SLD AK I+ALRRAKRRNMERL L GG A NS++DL+P LG +GLVY+ T+GE Sbjct: 298 DPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGE 357 Query: 362 EKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIA 421 EKFT++ + +P+S T+LIKG + L Q KDA+RDGLRAV N + D ++PGAGA +A Sbjct: 358 EKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVA 417 Query: 422 LSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQ 481 ++ L K KG+ + G++AFA+ALL+IPK L +NSGFD + L V+ A+ Sbjct: 418 MAEALVKY---KPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQ-----AE 469 Query: 482 DSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTL 541 S+ + VGVDLN G+ GIWD+Y V + + T IA+N+LL DE++RAG S+L Sbjct: 470 HSESGQLVGVDLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSL 529 Query: 542 K 542 K Sbjct: 530 K 530 >4B2T-G nrPDB Length = 545 Score = 559 bits (1440), Expect = e-159, Method: Composition-based stats. Identities = 148/541 (27%), Positives = 277/541 (51%), Gaps = 26/541 (4%) Query: 10 AESLRRDAALKV---NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEM 66 +++ +R++ KV N+ +A+ + ++ T LGPK +KML+D G I +T DG +L E+ Sbjct: 11 SQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREI 70 Query: 67 QIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIAR 126 Q+Q P A + + QDE GDGTT+V+ L GE+L A F+++ +HP ++ + A Sbjct: 71 QVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKAL 130 Query: 127 KESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQA 186 + + L KIS +++R+ +L + SS+ TKV + + + I DAV +V + Sbjct: 131 DDMISTLK--KISIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEEN 188 Query: 187 DNLDLHMVE---IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYE 243 ++ + + + ++ +D+ ++G++++ HP M +KN +++L+ SLEY+ Sbjct: 189 GRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYK 248 Query: 244 KTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDP 303 K E + + + ++ E +++ + II LK V+I +KGI Sbjct: 249 KGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKP----------DVVITEKGISD 298 Query: 304 MSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGF-SGLVYQETIGEE 362 ++ + NI A+RR ++ + R+ G + E+L + +G +GL+ + IG+E Sbjct: 299 LAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDE 358 Query: 363 KFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIAL 422 FT++TE DPK+CTIL++G++ L++ + ++D ++ NVL D ++PG GA +A+ Sbjct: 359 YFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAV 418 Query: 423 SRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQD 482 + L + G + A A+AL VIP+TL++N G + +L + + Sbjct: 419 AHALTEKSK---AMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAK----HT 471 Query: 483 SDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLK 542 + GV+ G D GIW+ V A A LL D+++ + Sbjct: 472 QENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGD 531 Query: 543 E 543 + Sbjct: 532 D 532 >3RUW-A nrPDB Length = 543 Score = 555 bits (1430), Expect = e-158, Method: Composition-based stats. Identities = 157/521 (30%), Positives = 266/521 (51%), Gaps = 20/521 (3%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 A ++N+ + + + + LGPKG KMLVD G++ +T DG +L EM ++ P A ++ Sbjct: 20 AQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHPAAKMLI 79 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 A Q++ GDGTTT V + GELLR+A + + VHP I+ G++ A +++ + L Sbjct: 80 EVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQKAQELLKTIA 139 Query: 138 ISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIM 197 + D+E L ++A +S+ K E L I+ +AV +V D + +D +++I Sbjct: 140 C--EVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEG-KVDKDLIKIE 196 Query: 198 QMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSAD 257 + S DT IKG+++D MP +V +A + +LN ++E ++TE ++ + Sbjct: 197 KKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNCAIEIKETETDAEIRITDPA 256 Query: 258 QRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILAL 317 + + E K + + +I V+ QKGID ++ AK I+A Sbjct: 257 KLMEFIEQEEKMLKDMVAEIK----------ASGANVLFCQKGIDDLAQHYLAKEGIVAA 306 Query: 318 RRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCT 377 RR K+ +ME+L TG ++ LS Q LG +GLV + I + +V E PK+ T Sbjct: 307 RRVKKSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEERKISGDSMIFVEECKHPKAVT 366 Query: 378 ILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAK 437 +LI+G+T + + + AV D + V ++D I+ G G+ + LS LR G Sbjct: 367 MLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAE---GIS 423 Query: 438 GKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGD 497 G+ + + AFA+AL VIP+TL +N+G D +++L V A S+ + G+++ G Sbjct: 424 GREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRA----AHASNGNKCAGLNVFTGA 479 Query: 498 SCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 D G+ + RV AI A LL D+++ A + Sbjct: 480 VEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAEK 520 >4V8R-AE nrPDB Length = 562 Score = 550 bits (1417), Expect = e-157, Method: Composition-based stats. Identities = 142/532 (26%), Positives = 260/532 (48%), Gaps = 27/532 (5%) Query: 17 AALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLI 76 A K ++ +A + S+++T+LGP+G K+L+ G I +T DG +L++M++ + A L+ Sbjct: 45 EAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELDNEIAKLL 104 Query: 77 ARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEF 136 + + +QD+ GDGTT VV L LL QA IQ+G+HP I +GF+ A K ++ L+E Sbjct: 105 VQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLAISKLEET 164 Query: 137 --KISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMV 194 IS +N R+FLL+ A++SL +K+ + + + +AV++V D ++D ++ Sbjct: 165 CDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRKDVDFDLI 224 Query: 195 EIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRV------KNAYVLILNVSLEYEKTEVN 248 ++ S D+ I G++LD HP MP V + IL E K + Sbjct: 225 KMQGRVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPFEPPKPKTK 284 Query: 249 SGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDV 308 SS ++ KL E+ + + V+I Q G D + + Sbjct: 285 HKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAG----------ADVVICQWGFDDEANHL 334 Query: 309 FAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG--EEKFTY 366 ++++ A+R + +E + + T G +DLS LG +Y++ G +++ Sbjct: 335 LLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEFGTTKDRMLI 394 Query: 367 VTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYL 426 + ++ + K+ T ++GS + + + A+ D L V N++KD ++ G GA + +S + Sbjct: 395 IEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGGAAEVTMSLAV 454 Query: 427 RSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDET 486 + +G + FA+AL IP TL +NSG DP+ L+ ++ + Q ++ Sbjct: 455 SEEADKQ---RGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSK----QLKEKI 507 Query: 487 RYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 +GVD S D + D + + I AT + +L D ++ +G+ Sbjct: 508 SNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGK 559 >5GW4-h nrPDB Length = 550 Score = 534 bits (1377), Expect = e-152, Method: Composition-based stats. Identities = 133/542 (24%), Positives = 259/542 (47%), Gaps = 25/542 (4%) Query: 2 SLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKV 61 ++ +L ++ + + N+ + +Q L+ LGP G+ ++V ++ DG Sbjct: 9 TIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGAT 68 Query: 62 LLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDG 121 +L + + P A + + AQD GDGTT+V L GEL+++A F++EG+ +I G Sbjct: 69 ILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKG 128 Query: 122 FEIARKESMKFLDEFKISKTN-LSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLS 180 + A +++ ++E + T+ S+ RE L + AR+++ +K+ + + + DAVLS Sbjct: 129 YRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLS 188 Query: 181 VYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDM---PTRVKNAYVLILN 237 + ++LD ++ I ++ + +++ FI G+ + P + N +L LN Sbjct: 189 L---DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLN 245 Query: 238 VSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIIN 297 V LE + + N+ + + +E + + KL+++ + ++++ Sbjct: 246 VELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEE----------TGANIVLS 295 Query: 298 QKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQE 357 + I ++ FA NI R +M R+ GG Q++ D+ P+ LG L + Sbjct: 296 KLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEM 355 Query: 358 TIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGA 417 IG E++ K+CT+L++G +A+ + ++ D + V L++K I+ G GA Sbjct: 356 QIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGA 415 Query: 418 FYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDEL 477 + +S+ LR + GK + I AFA+AL VIP+ L +N+GFD +++L + Sbjct: 416 TEMEVSKCLRDYSKT---IAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLR--- 469 Query: 478 DDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAG 537 S ++ GV + D + +W+ V NA+ AT + +L DE + Sbjct: 470 --LAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNK 527 Query: 538 RS 539 S Sbjct: 528 GS 529 >5GW5-g nrPDB Length = 534 Score = 533 bits (1373), Expect = e-152, Method: Composition-based stats. Identities = 147/548 (26%), Positives = 267/548 (48%), Gaps = 31/548 (5%) Query: 3 LQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVL 62 + +N E A N+T+A+ + V+ T LGPK LKML+D G + LT DG + Sbjct: 5 VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAI 64 Query: 63 LTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQ-AHRFIQEGVHPRIITDG 121 L E+ + P A + + QDE GDGTTTV+ L GE+L Q A I++ +HP II Sbjct: 65 LREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQA 124 Query: 122 FEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSV 181 + A ++++ + + +SK + + ++ ++S+ TK +E + + DAV +V Sbjct: 125 LKKALTDALEVIKQ--VSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTV 182 Query: 182 YDAQAD------NLDLHM---VEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAY 232 N ++ + V + ++ D+ +KG++L+ HP M ++N Sbjct: 183 RKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPR 242 Query: 233 VLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKG 292 V++L+ LEY+K E + + +++ E + V ++I+ ++ Sbjct: 243 VVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRP---------- 292 Query: 293 FVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGF-S 351 ++I +KG+ ++ K LRR K+ + R+ VTG N VEDL +G Sbjct: 293 TLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNC 352 Query: 352 GLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNI 411 GL E IG+E F+++ +PK+CTI+++G + L + ++D + NV+ ++ Sbjct: 353 GLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSL 412 Query: 412 IPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLA 471 PG GA +A+S L +G + +A A+A+ IP+TL++N+G DP+ +L+ Sbjct: 413 SPGGGATEMAVSVKLAEKAKQ---LEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLS 469 Query: 472 MVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCD 531 + A+ + G+D + G D GIW+ + + ++ A A LL D Sbjct: 470 QLR-----AKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVD 524 Query: 532 ELLRAGRS 539 +++ R Sbjct: 525 DIVSGVRK 532 >4B2T-A nrPDB Length = 556 Score = 533 bits (1372), Expect = e-151, Method: Composition-based stats. Identities = 139/532 (26%), Positives = 270/532 (50%), Gaps = 26/532 (4%) Query: 16 DAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVL 75 +A NV +A + ++++++LGP G KMLVD G++ +T DG +L ++++ P A + Sbjct: 15 EAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKV 74 Query: 76 IARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDE 135 + A QD+ GDGTT+VV + ELL+ A +++ +HP + G+ +A KE+++++ E Sbjct: 75 LCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYISE 134 Query: 136 FKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVY--DAQADN-LDLH 192 I T R+ L+ A++S+ +KV + +V DAVL++ D + ++ Sbjct: 135 NLIINT-DELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIRGQPRYPVN 193 Query: 193 MVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFF 252 + +++ S ++ I G L+ MP R+ NA + L+ SL+ K ++ Sbjct: 194 SINVLKAHGRSQMESMLINGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVV 253 Query: 253 YSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKH 312 + ++ D++ E +++KI+ VI+ GID M L F + Sbjct: 254 ITDPEKLDQIRQRESDITKERIQKIL----------ATGANVILTTGGIDDMCLKYFVEA 303 Query: 313 NILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQ------ILGFSGLVYQETIGEEKFTY 366 +A+RR +R+++R+ +G +++ +L + +LG + V QE I +++ Sbjct: 304 GAMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELIL 363 Query: 367 VTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYL 426 + S +++++G+ + + + ++ D L V VL+ K+++PG GA ALS YL Sbjct: 364 IKNTKARTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYL 423 Query: 427 RSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDET 486 + + + + I FA +L VIP TL N+ D D++A + ++AQ + E Sbjct: 424 ENYATS---MGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPER 480 Query: 487 ---RYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLR 535 +++G+DL G D G+++ V ++ AT A +L D+L++ Sbjct: 481 KNLKWIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIK 532 >3AQ1-B nrPDB Length = 500 Score = 531 bits (1368), Expect = e-151, Method: Composition-based stats. Identities = 152/499 (30%), Positives = 250/499 (50%), Gaps = 23/499 (4%) Query: 45 MLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQ 104 MLVD G+I +T DG +L EM IQ P A +I + QD GDGTTT L GELL + Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 105 AHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDA 164 A I +GVH II++G+ A ++ + L+ I+ + +D L+++A +++ K Sbjct: 61 AEELIMKGVHSTIISEGYRHAAEKCREILETITIAIS--PDDEAALIKIAGTAITGKGAE 118 Query: 165 DLTEVLTPIVTDAVLSVYDAQADNLD---LHMVEIMQMQHLSPKDTTFIKGLVLDHGGRH 221 E L+ + AV S+ + + D L L ++I + S D+ I GLV+D H Sbjct: 119 AYKEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKERSH 178 Query: 222 PDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLK 281 P+MP +V+NA +L+L+ +E+ KTEV+S +S Q E K + +K+I Sbjct: 179 PNMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKVI--- 235 Query: 282 NEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVE 341 V+ QKGID M+ K I A+RR K+ +++RL VTG ++ Sbjct: 236 -------ASGANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLD 288 Query: 342 DLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRA 401 ++ + +G +GLV ++ + K TYVT + K+ T+L+ G T + + A+ D L Sbjct: 289 QITTEDVGTAGLVEEKEVRGGKMTYVTGCQNSKAVTVLLHGGTEHVVDSLDHALNDALHV 348 Query: 402 VANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKN 461 V V++D ++ G G+ + LS L KG+ + + FAEAL VIP L +N Sbjct: 349 VGVVIEDGKVVVGGGSSEVELSLRLSEYAST---LKGREQLAVSKFAEALEVIPVALAEN 405 Query: 462 SGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGAT 521 +G DP+D++ + Q + G+++ G+ D + + R+ AI A Sbjct: 406 AGLDPIDIMVELRS-----QHEKGNKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAM 460 Query: 522 GIASNLLLCDELLRAGRST 540 +L D+++ + S Sbjct: 461 EATVMILRIDDVVASKGSA 479 >4B2T-D nrPDB Length = 542 Score = 530 bits (1365), Expect = e-151, Method: Composition-based stats. Identities = 139/528 (26%), Positives = 268/528 (50%), Gaps = 19/528 (3%) Query: 10 AESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQ 69 + + N+++A+ + + T+LGPKG KM+ DG G++ +T DG +L +MQ+ Sbjct: 28 QDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVL 87 Query: 70 SPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKES 129 P A ++ + AQD GDGTT+VV + G LL + +Q+G+HP II++ F+ A ++ Sbjct: 88 HPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKG 147 Query: 130 MKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDA-QADN 188 ++ L + S+ +DRE LL A +SL +KV + + +L+P+ DAV+ V D A + Sbjct: 148 IEILTDM--SRPVELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATATS 205 Query: 189 LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVN 248 +DL ++I++ + D ++GLVL + + TRV+ A + ++ L KT+++ Sbjct: 206 VDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGI-TRVEKAKIGLIQFCLSAPKTDMD 264 Query: 249 SGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDV 308 + S Q D++ ER ++ +K+I V + I + + ++L Sbjct: 265 NQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKS-----ILRDALSDLALHF 319 Query: 309 FAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETI-GEEKFTYV 367 K I+ ++ +R ++E + G + V+ + +LG + L + ++ G K + Sbjct: 320 LNKMKIMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSGKLIKI 379 Query: 368 TENTDP-KSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYL 426 T P K+ TI+++GS + + + ++ D L + ++K + +I G GA I L+ L Sbjct: 380 TGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRL 439 Query: 427 RSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDET 486 + G I AFA+A+ VIP TL +N+G +P+ + + + + + Sbjct: 440 TEYSRT---LSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRN-----RHAQGE 491 Query: 487 RYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELL 534 + G+++ G + E + V +A+T AT ++L D+++ Sbjct: 492 KTTGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVV 539 >3IYF-A nrPDB Length = 521 Score = 526 bits (1354), Expect = e-149, Method: Composition-based stats. Identities = 157/521 (30%), Positives = 261/521 (50%), Gaps = 42/521 (8%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 A ++N+ + + + + LGPKG KMLVD G++ +T DG +L EM ++ P A ++ Sbjct: 20 AQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHPAAKMLI 79 Query: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 A Q++ GDGTTT V + GELLR+A + + VHP I+ G++ A +++ + L Sbjct: 80 EVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQKAQELLKTIA 139 Query: 138 ISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIM 197 + D+E L ++A +S+ K E L I+ +AV +V D + +D +++I Sbjct: 140 C--EVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEG-KVDKDLIKIE 196 Query: 198 QMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSAD 257 + S DT IKG+++D MP +V +A + +LN ++E +E+ Sbjct: 197 KKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNCAIEETASEM---------- 246 Query: 258 QRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILAL 317 LK+ V + V+ QKGID ++ AK I+A Sbjct: 247 ----------------------LKDMVAEIKASGANVLFCQKGIDDLAQHYLAKEGIVAA 284 Query: 318 RRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCT 377 RR K+ +ME+L TG +++DLS Q LG +GLV + I + +V E PK+ T Sbjct: 285 RRVKKSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEERKISGDSMIFVEECKHPKAVT 344 Query: 378 ILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAK 437 +LI+G+T + + + AV D + V ++D I+ G G+ + LS LR G Sbjct: 345 MLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAE---GIS 401 Query: 438 GKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGD 497 G+ + + AFA+AL VIP+TL +N+G D +++L V A S+ + G+++ G Sbjct: 402 GREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRA----AHASNGNKCAGLNVFTGA 457 Query: 498 SCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 D G+ + RV AI A LL D+++ A + Sbjct: 458 VEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAEK 498 >4V94-A nrPDB Length = 559 Score = 508 bits (1307), Expect = e-144, Method: Composition-based stats. Identities = 137/549 (24%), Positives = 260/549 (47%), Gaps = 32/549 (5%) Query: 16 DAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVL 75 D NV + + +V++++LGP G KMLVD G+ +T DG +L+ + +Q P + Sbjct: 23 DDIRNQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDVQHPAGKI 82 Query: 76 IARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDE 135 + A QD GDGTT+VV + ELL++A+ ++ +HP I GF +A +E+++F++E Sbjct: 83 LVELAQQQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGFRVALREAIRFINE 142 Query: 136 FKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQAD---NLDLH 192 +S + + +E L+ +A++S+ +K+ ++ + +V DA+L+V + + Sbjct: 143 V-LSTSVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKTQNSKGEIKYPVK 201 Query: 193 MVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVK--NAYVLILNVSLEYEKTEVNSG 250 V +++ S ++ + G L+ MP R+ N + L+++L+ + + Sbjct: 202 AVNVLKAHGKSATESLLVPGYALNCTVASQAMPKRIAGGNVKIACLDLNLQKARMAMGVQ 261 Query: 251 FFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFA 310 +Q +++ E V ++KKIID + V++ KGID + L F Sbjct: 262 INIDDPEQLEQIRKREAGIVLERVKKIIDAGAQ----------VVLTTKGIDDLCLKEFV 311 Query: 311 KHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQI------LGFSGLVYQETIGEEKF 364 + I+ +RR K+ ++ R+ TG +S+ +L + LG V Q +++ Sbjct: 312 EAKIMGVRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQAKFSDDEC 371 Query: 365 TYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSR 424 + + S +I+++G+ Y+L + + ++ D L V L+ N++PG G AL+ Sbjct: 372 ILIKGTSKHSSSSIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVPGGGCVEAALNI 431 Query: 425 YLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSD 484 YL + + + I FA ALL+IPKTL N+ D +++A + +Q + Sbjct: 432 YLDNFATT---VGSREQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAK 488 Query: 485 -------ETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAG 537 R G+DL G D G+ + ++ A +L D ++ Sbjct: 489 PEDVKRRSYRNYGLDLIRGKIVDEIHAGVLEPTISKVKSLKSALEACVAILRIDTMITVD 548 Query: 538 RSTLKETPQ 546 KE P Sbjct: 549 PEPPKEDPH 557 >4V8R-AB nrPDB Length = 527 Score = 504 bits (1298), Expect = e-143, Method: Composition-based stats. Identities = 139/547 (25%), Positives = 269/547 (49%), Gaps = 27/547 (4%) Query: 1 MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGN-IKLTKDG 59 MS+Q+ + R + A A + ++++ LGPKG K+L + N +T DG Sbjct: 1 MSVQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDG 60 Query: 60 KVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQE-GVHPRII 118 +L + + +P A ++ + QD+ GDGTT+V L ELLR+A + I + +HP+ I Sbjct: 61 ATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTI 120 Query: 119 TDGFEIARKESMKFLDEFKISKT-NLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDA 177 +G+ +A ++ L + + + + + RE L+ +A+++L +K+ + + + T+A Sbjct: 121 IEGYRLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNA 180 Query: 178 VLSVYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILN 237 +L + + +L ++I+++ D+ +G +L + + P R++NA +LI N Sbjct: 181 ILRLK----GSTNLEHIQIIKILGGKLSDSFLDEGFILAKKFGN-NQPKRIENAKILIAN 235 Query: 238 VSLEYEKTEV-NSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVII 296 +L+ +K ++ + F S + +L +ER+ + K+ KI I Sbjct: 236 TTLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGI----------NTFI 285 Query: 297 NQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQ 356 N++ I +F I ++ A +ERL LVTGGE ++ ++ S LG ++ + Sbjct: 286 NRQLIYDYPEQLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEE 345 Query: 357 ETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAG 416 +GE+ F + ++CTI+++G+T L + + ++ D L ++ K+ + G G Sbjct: 346 IMLGEQPFLKFSGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGG 405 Query: 417 AFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDE 476 + +S+ + + N GK +EAFA AL +P L N+GFD ++++ + Sbjct: 406 CAEMVMSKAVDTEAQN---IDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSS 462 Query: 477 LDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRA 536 + + G+DLN G D GI +SY++ R ++ A+ A LL D ++RA Sbjct: 463 IYN-----GISTSGLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRA 517 Query: 537 GRSTLKE 543 T Sbjct: 518 RPRTANR 524 >5GW4-d nrPDB Length = 528 Score = 497 bits (1279), Expect = e-141, Method: Composition-based stats. Identities = 143/525 (27%), Positives = 255/525 (48%), Gaps = 19/525 (3%) Query: 13 LRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPT 72 + K N+ +A + + T+LGPKG KM+ G I ++ DG +L +M I P Sbjct: 15 EKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV 74 Query: 73 AVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKF 132 A ++ +AAQD GDGTT+VV L G LL A R + +G+HP II D F+ A K S+ Sbjct: 75 ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDI 134 Query: 133 LDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLH 192 L E +DRE L++ A +SL +K+ + + L P+ D+VL + D + N+DL+ Sbjct: 135 LLEM--CHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLN 192 Query: 193 MVEIMQMQHLSPKDTTFIKGLVLDHG-GRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGF 251 + +++ + DT I G+VL + PTR + A + ++ + K + + Sbjct: 193 DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNI 252 Query: 252 FYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAK 311 + Q DK+ ER ++ KKI K V + I + ++ ++L +K Sbjct: 253 IVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKS-----ILRDAVNDLALHFLSK 307 Query: 312 HNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTE-- 369 NI+ ++ +R +E L G + +E + LG + LV + K VT Sbjct: 308 LNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIR 367 Query: 370 -NTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRS 428 N + +++I+G+ + + +T+ ++ D L + ++K++ +I G GA I +SR L Sbjct: 368 NNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSK 427 Query: 429 ANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRY 488 + +G + FA AL VIP TL +N+G + + V+ + + ++ + +D Sbjct: 428 EARS---MEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND---- 480 Query: 489 VGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDEL 533 G+ + + + E I V +AIT A+ ++L D++ Sbjct: 481 -GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 >4B2T-B nrPDB Length = 535 Score = 489 bits (1258), Expect = e-138, Method: Composition-based stats. Identities = 130/538 (24%), Positives = 261/538 (48%), Gaps = 27/538 (5%) Query: 3 LQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDG--AGNIKLTKDGK 60 + + A+ R + A + A + ++++ LGPKG K+L+ ++ +T DG Sbjct: 9 VNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGA 68 Query: 61 VLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITD 120 +L + + +P A ++ + QD+ GDGTT+V L ELLR+A I + +HP+ I Sbjct: 69 TILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIA 128 Query: 121 GFEIARKESMKFLDEFKI-SKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVL 179 G+ A K + + L + ++ R+ L+ +A ++L +K+ + T + +AVL Sbjct: 129 GWREATKAARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVL 188 Query: 180 SVYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVS 239 + + +L + +++ S D+ +G +LD + P R++NA +LI N Sbjct: 189 RLKGSG----NLEAIHVIKKLGGSLADSYLDEGFLLDKKIG-VNQPKRIENAKILIANTG 243 Query: 240 LEYEKTEV-NSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQ 298 ++ +K ++ S S + ++ +E++ + K+++I+ IN+ Sbjct: 244 MDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILK----------HGINCFINR 293 Query: 299 KGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQET 358 + I +F ++A+ A +ERL LVTGGE ++ + LG L+ + Sbjct: 294 QLIYNYPEQLFGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVM 353 Query: 359 IGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAF 418 IGE+K + + ++CTI+++G+T L + + ++ D L +A +KD + G G Sbjct: 354 IGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCS 413 Query: 419 YIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELD 478 + ++ + GK +E++A+AL ++P + N+G+D D++A + Sbjct: 414 EMLMAHAVTQLASRT---PGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLR---- 466 Query: 479 DAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRA 536 A S+ G+D+ G D ++ GI +S++V R + A A +L D +++A Sbjct: 467 -AAHSEGKTTAGLDMKEGTIGDMSVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKA 523 >4B2T-Q nrPDB Length = 548 Score = 482 bits (1242), Expect = e-136, Method: Composition-based stats. Identities = 122/533 (22%), Positives = 236/533 (44%), Gaps = 25/533 (4%) Query: 16 DAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVL 75 + A+ N+ + + L T GP G KM+++ + +T D +L E+++Q P A + Sbjct: 26 EEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKM 85 Query: 76 IARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDE 135 I A+ Q++ GDGT V+ G LL A ++ G+ + +G+EIA K++ + L + Sbjct: 86 IVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEGYEIACKKAHEILPD 145 Query: 136 FKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVE 195 D + + + +S+++K + L ++ A +S++ + + ++ + Sbjct: 146 LVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEV-FLAKLIAQACVSIF-PDSGHFNVDNIR 203 Query: 196 IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSS 255 + ++ ++ + G+V T VK+A + + + + TE S Sbjct: 204 VCKILGSGVHSSSVLHGMVFKKET--EGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKS 261 Query: 256 ADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNIL 315 A++ + E +DA++K I D V++ + M+L K+NI+ Sbjct: 262 AEELMNFSKGEENLMDAQVKAIAD----------TGANVVVTGGRVADMALHYANKYNIM 311 Query: 316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVT-ENTDPK 374 +R + ++ RL G A + + +G VY +G+ + E D Sbjct: 312 LVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGA 371 Query: 375 SCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKL 434 TI+++GST + + AV DG+ + +DK ++PG GA I L++ + S Sbjct: 372 ISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGET-- 429 Query: 435 GAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLN 494 G + I+ FAEA IP+ L +NSG +V++ + A + + VG+D+ Sbjct: 430 -CPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLY-----AVHQEGNKNVGLDIE 483 Query: 495 IG--DSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKETP 545 D G+ D+Y AI AT A +L D+++ A + + P Sbjct: 484 AEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPP 536 >5GW5-q nrPDB Length = 568 Score = 479 bits (1234), Expect = e-135, Method: Composition-based stats. Identities = 143/571 (25%), Positives = 255/571 (44%), Gaps = 39/571 (6%) Query: 1 MSLQL-LNPKAESLRR--------DAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAG 51 MSL+L NP A ++ D + ++ + L + T++GP G K++V+ G Sbjct: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 Query: 52 NIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQE 111 I +T D +L E+ I P ++ A Q GDGT V+ L GELL + + I Sbjct: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 Query: 112 GVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLT 171 G+ I G+ +ARK ++K LDE + + ND+ LL++ + + +K ++L+ Sbjct: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILS 179 Query: 172 PIVTDAVLSVYDAQADN-----LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGG-RHPDMP 225 +V++AV V ++ + ++++ S ++T IKG+V + H Sbjct: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSL 239 Query: 226 TRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVC 285 + K V + L+ TE +A + + E K +DA +K+I D+ E Sbjct: 240 SEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVE-- 297 Query: 286 GMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSP 345 I+ G+ ++L ++ IL L+ + + RL V G + +P Sbjct: 298 --------CIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTP 349 Query: 346 QILGFSGLVYQETIGEEKFTYVTENTD--PKSCTILIKGSTHYALAQTKDAVRDGLRAVA 403 + LG V IG ++ T + ++ TI+++G+T L + A+ DG+ AV Sbjct: 350 EELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVK 409 Query: 404 NVLKD--KNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKN 461 ++K ++PGAGA I L + G + I+ FA A V+P+TL + Sbjct: 410 GLMKPSGGKLLPGAGATEIELISRITKYGERT---PGLLQLAIKQFAVAFEVVPRTLAET 466 Query: 462 SGFDPLDVLAMV---EDELDDAQDSDETRYVGVDLNI---GDSCDPTIEGIWDSYRVLRN 515 +G D +VL + + + + Y GVD++ D E I+D + Sbjct: 467 AGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKF 526 Query: 516 AITGATGIASNLLLCDELLRAGRSTLKETPQ 546 AI AT A+ +L D+++ A ++ PQ Sbjct: 527 AINVATEAATTVLSIDQIIMAKKAGGPRAPQ 557 >4V8R-AG nrPDB Length = 590 Score = 422 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 132/594 (22%), Positives = 251/594 (42%), Gaps = 67/594 (11%) Query: 3 LQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVL 62 + +N E A N+T+A+ + V+ T LGPK LKML+D G + LT DG + Sbjct: 5 VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAI 64 Query: 63 LTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQ-AHRFIQEGVHPRIITDG 121 L E+ + P A + + QDE GDGTTTV+ L GE+L Q A I++ +HP II Sbjct: 65 LREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQA 124 Query: 122 FEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSV 181 + A ++++ + + +SK + + ++ ++S+ TK +E + + DAV +V Sbjct: 125 LKKALTDALEVIKQ--VSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTV 182 Query: 182 YDAQAD------NLDLHM---VEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAY 232 N ++ + V + ++ D+ +KG++L+ HP M ++N Sbjct: 183 RKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPR 242 Query: 233 VLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERK---FVDAKLKKIIDLKNEVCGMDP 289 V++L+ LEY+K E + + +++ E + + ++ + Sbjct: 243 VVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVS 302 Query: 290 DKGFVIINQKGIDPMSLDVFAKHNILA----------LRRAKRRNMERLQ-----LVTGG 334 D + + G + + +N +A + K ++ + G Sbjct: 303 DLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGD 362 Query: 335 EAQNSVEDLSPQILGFSGLVYQETIGEEK------FTYVTENT----------------- 371 E + +++ G Q G K F V+ Sbjct: 363 EYFSFLDNCKEPGSGSGWSHPQFEKGSGKRRWKKNFIAVSAANRFKKISSSGALGSGHHH 422 Query: 372 ------DPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRY 425 K+CTI+++G + L + ++D + NV+ ++ PG GA +A+S Sbjct: 423 HHHHHGSGKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVK 482 Query: 426 LRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDE 485 L +G + +A A+A+ IP+TL++N+G DP+ +L+ + A+ + Sbjct: 483 LAEKAKQ---LEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR-----AKHAQG 534 Query: 486 TRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRS 539 G+D + G D GIW+ + + ++ A A LL D+++ R Sbjct: 535 NFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRK 588 >5X9V-A nrPDB Length = 521 Score = 414 bits (1064), Expect = e-116, Method: Composition-based stats. Identities = 133/542 (24%), Positives = 241/542 (44%), Gaps = 48/542 (8%) Query: 3 LQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVL 62 ++ N E R AL N + + L V+ +LGPKG MLVD G + +T DG + Sbjct: 1 MKKENQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTI 60 Query: 63 LTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGF 122 LT M Q P A ++ A AQ+ GDGTTT L G L+ + I +GV + G Sbjct: 61 LTLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGM 120 Query: 123 EIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVY 182 A ++ + + I ++++DR LL A K+ E + I+ DA + Sbjct: 121 NRALNHALFLIRKNAIKVGSITDDR--LLAAA------KIAGRGDERVAAILRDAAAMLE 172 Query: 183 DAQADN----LDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNV 238 D D DL + ++ DTT I G+V++ + +++ +L+L+ Sbjct: 173 DKLQDPGFKLADLVLAKV-------GADTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDD 225 Query: 239 SLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQ 298 L E+ E + + +Q K +K LKK+ +L + +I+ Sbjct: 226 GLYPEEVEEEALASEAGFEQYLK----NQKIFQENLKKLKELGVK----------LILLT 271 Query: 299 KGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSP-----QILGFSGL 353 +GI ++ + ++ I+ + R ++ ++R+ TG A P ++LG++ Sbjct: 272 RGISDIAEEFCYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYART 331 Query: 354 VYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIP 413 + ++ FT + + T+LI +T + + + +D + A + ++P Sbjct: 332 CFYDS--RLDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSG-VLP 388 Query: 414 GAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMV 473 G GAF++ LSR + S K G G+ AF+EAL V + + +N+GF+ L+ L + Sbjct: 389 GGGAFFLYLSREVESL---KNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDL 445 Query: 474 EDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDEL 533 Q +G+D G+ D G+ D V+ A+ A+ +A +LL + + Sbjct: 446 ----MTLQVQKNNYALGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTI 501 Query: 534 LR 535 ++ Sbjct: 502 IK 503 >4V4O-A nrPDB Length = 543 Score = 231 bits (588), Expect = 7e-61, Method: Composition-based stats. Identities = 100/582 (17%), Positives = 221/582 (37%), Gaps = 104/582 (17%) Query: 11 ESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQ- 69 E+ RR VN + + ++ LGP+G +L G+ +TKDG + E++++ Sbjct: 9 EAARRALERGVN-----AVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELED 63 Query: 70 ---SPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIAR 126 + A L+ A+ +++ GDGTTT L ++R+ + + G +P + G E A Sbjct: 64 HLENIGAQLLKEVASKTNDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAV 123 Query: 127 KESMKFLDEFKISKTNLSNDREFLLQVARSSLL-TKVDADLTEVLTPIVTDAVLSVYDAQ 185 + +++ + I DR+ + +VA S +V + + + + + +++V +++ Sbjct: 124 EAAVEKIKALAIP----VEDRKAIEEVATISANDPEVGKLIADAMEKVGKEGIITVEESK 179 Query: 186 ADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPD-MPTRVKNAYVLILNVSLEYEK 244 + +L VE Q KG + + +P+ M +++A++LI+ Sbjct: 180 SLETELKFVEGYQFD----------KGYISPYFVTNPETMEAVLEDAFILIV-------- 221 Query: 245 TEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPM 304 S+ + + +++ + + D + ++ + Sbjct: 222 -----EKKVSNVRELLPIL-----------EQVAQTGKPLLIIAEDVEGEALATLVVNKL 265 Query: 305 SLDV-FAKHNILALRRAKRRNMERLQLVTGGEAQN-----SVEDLSPQILGFSGLVYQET 358 + A ++ ++ + VTGG + +E+ + +LG + V Sbjct: 266 RGTLSVAAVKAPGFGDRRKEMLKDIAAVTGGTVISEELGFKLENATLSMLGRAERV---R 322 Query: 359 IGEEKFTYVTENTDPK-----------------------------------SCTILIKGS 383 I +++ T V + I + + Sbjct: 323 ITKDETTIVGGKGKKEDIEARINGIKKELETTDSEYAREKLQERLAKLAGGVAVIRVGAA 382 Query: 384 THYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTG 443 T L + K D L A +++ I+PG G + L R + + +G TG Sbjct: 383 TETELKEKKHRFEDALNATRAAVEEG-IVPGGG---VTLLRAISAVEELIKKLEGDEATG 438 Query: 444 IEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTI 503 + AL + + +N+G++ ++ + E + + G + G+ D Sbjct: 439 AKIVRRALEEPARQIAENAGYEGSVIVQQILAETKNPR-------YGFNAATGEFVDMVE 491 Query: 504 EGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKETP 545 GI D +V R+A+ A I + +L + ++ + TP Sbjct: 492 AGIVDPAKVTRSALQNAASIGALILTTEAVVAEKPEKKESTP 533 >1IOK-A nrPDB Length = 545 Score = 211 bits (537), Expect = 7e-55, Method: Composition-based stats. Identities = 106/552 (19%), Positives = 205/552 (37%), Gaps = 68/552 (12%) Query: 15 RDAALK-VNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQI----Q 69 RD LK VN+ L ++ LGPKG ++ G ++TKDG + E+++ + Sbjct: 13 RDRMLKGVNI-----LADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELSDKFE 67 Query: 70 SPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKES 129 + A ++ A+ ++ GDGTTT L ++R+ + + G++P + G ++A + Sbjct: 68 NMGAQMVREVASRTNDEAGDGTTTATVLAQAIVREGLKAVAAGMNPMDLKRGIDVATAKV 127 Query: 130 MKFLDEFKISKTNLSNDREFLLQVARSSLLTK--VDADLTEVLTPIVTDAVLSVYDAQAD 187 ++ + S ND + QV S + + + E + + + V++V + + Sbjct: 128 VEAIK----SAARPVNDSSEVAQVGTISANGESFIGQQIAEAMQRVGNEGVITVEENKGM 183 Query: 188 NLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPD-MPTRVKNAYVLILN---VSLEYE 243 ++ +VE MQ +G + + + D M +++AY+L+ SL+ Sbjct: 184 ETEVEVVEGMQFD----------RGYLSPYFVTNADKMIAELEDAYILLHEKKLSSLQPM 233 Query: 244 KTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKG--------FVI 295 + S + K+ P G + Sbjct: 234 VPLLESVIQSQKPLLIVAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIA 293 Query: 296 INQKG--IDPMSLDVFAKHNILALRRAKRRNMER----LQLVTG--GEAQNSVEDLSPQI 347 I G I I L RAK+ ++ + + G E + V + Q Sbjct: 294 ILTGGQVISEDLGMKLENVTIDMLGRAKKVSINKDNTTIVDGAGEKAEIEARVSQIRQQ- 352 Query: 348 LGFSGLVYQETIGEEKFTYVTENTDPKSCTILIK--GSTHYALAQTKDAVRDGLRAVANV 405 + + T ++ +I+ G T + + KD V D L A Sbjct: 353 ------IEETTSDYDREKLQERVAKLAGGVAVIRVGGMTEIEVKERKDRVDDALNATRAA 406 Query: 406 LKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFD 465 +++ I+ G G + ++ L + GA GI AL + + +N+G D Sbjct: 407 VQEG-IVVGGGVALVQGAKVLEGLS----GANSDQDAGIAIIRRALEAPMRQIAENAGVD 461 Query: 466 PLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIAS 525 V V + D A G + + D G+ D +V+R A+ A +A Sbjct: 462 GAVVAGKVRESSDKA--------FGFNAQTEEYGDMFKFGVIDPAKVVRTALEDAASVAG 513 Query: 526 NLLLCDELLRAG 537 L+ + ++ Sbjct: 514 LLITTEAMIAEK 525 >4AAR-A nrPDB Length = 548 Score = 201 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 90/557 (16%), Positives = 194/557 (34%), Gaps = 99/557 (17%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQ----SPTA 73 A + L ++ LGPKG +L G +TKDG + E++++ + A Sbjct: 12 ARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGA 71 Query: 74 VLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFL 133 ++ A+ ++ GDGTTT L ++ + + + G++P + G + A +++ L Sbjct: 72 QMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEEL 131 Query: 134 DEFKISKTNLSNDREFLLQVARSSLLT--KVDADLTEVLTPIVTDAVLSVYDAQADNLDL 191 + +D + + QV S + V + E + + + V++V D +L Sbjct: 132 KALSVP----CSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDEL 187 Query: 192 HMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGF 251 +VE MQ D ++ ++ +++ ++L+ + Sbjct: 188 DVVEGMQF------DRGYLSPYFINKPET---GAVELESPFILLADK------------- 225 Query: 252 FYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAK 311 S+ + + + AK K + + E + V+ +GI ++ Sbjct: 226 KISNIREMLPVLEA-----VAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVA-----A 275 Query: 312 HNILALRRAKRRNMERLQLVTGGEAQN-----SVEDLSPQILGFSGLVYQETIGEEKFTY 366 ++ ++ + +TGG + +E + + LG + V I ++ T Sbjct: 276 VKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVV---INKDTTTI 332 Query: 367 VTENTDPKS-----------------------------------CTILIKGSTHYALAQT 391 + + + I + +T + + Sbjct: 333 IDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEK 392 Query: 392 KDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEAL 451 K V L A +++ ++ G G I ++ L G GI+ A+ Sbjct: 393 KARVEAALHATRAAVEEG-VVAGGGVALIRVASKLADLR----GQNEDQNVGIKVALRAM 447 Query: 452 LVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYR 511 + +V N G +P V V G + + + GI D + Sbjct: 448 EAPLRQIVLNCGEEPSVVANTV---------KGGDGNYGYNAATEEYGNMIDMGILDPTK 498 Query: 512 VLRNAITGATGIASNLL 528 V R+A+ A +A ++ Sbjct: 499 VTRSALQYAASVAGLMI 515 >4PJ1-A nrPDB Length = 558 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 101/543 (18%), Positives = 197/543 (36%), Gaps = 72/543 (13%) Query: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSP----TA 73 A + + + L + +GPKG ++ G+ K+TKDG + + ++ A Sbjct: 38 ARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGA 97 Query: 74 VLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFL 133 L+ A +E GDGTTT L + ++ I +G +P I G +A + L Sbjct: 98 KLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAEL 157 Query: 134 DEFKISKTNLSNDREFLLQVARSSLLT--KVDADLTEVLTPIVTDAVLSVYDAQADNLDL 191 + T E + QVA S ++ +++ + + V++V D + N +L Sbjct: 158 KKQSKPVTTP----EEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDEL 213 Query: 192 HMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLI----------LNVSLE 241 ++E M+ D +I ++ ++AYVL+ + +LE Sbjct: 214 EIIEGMKF------DRGYISPYFIN---TSKGQKCEFQDAYVLLSEKKISSIQSIVPALE 264 Query: 242 YEKTEVNSGFFYSSADQ---------------RDKLAASERKFVDAKLKKIIDLKNEVCG 286 + +A F D + ++ D+ G Sbjct: 265 IANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGG 324 Query: 287 MDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTG--GEAQNSVEDLS 344 + + +N ++ + K + + ++ L G + + ++++ Sbjct: 325 AVFGEEGLTLN---LEDVQPHDLGKVGKVIVT----KDDAMLLKGKGDKAQIEKRIQEII 377 Query: 345 PQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVAN 404 Q+ + +E + E K + G++ + + KD V D L A Sbjct: 378 EQLDVTTSEYEKEKLNERLAKLSDGVAVLK-----VGGTSDVEVNEKKDRVTDALNATRA 432 Query: 405 VLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGF 464 +++ I+ G G + L S K GIE L + T+ KN+G Sbjct: 433 AVEEG-IVLGGGCALLRCIPALDSLTPANED----QKIGIEIIKRTLKIPAMTIAKNAGV 487 Query: 465 DPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIA 524 + ++ + + VG D GD + +GI D +V+R A+ A G+A Sbjct: 488 EGSLIVEKIM---------QSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVA 538 Query: 525 SNL 527 S L Sbjct: 539 SLL 541 >1GN1-A nrPDB Length = 178 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 49/182 (26%), Positives = 98/182 (53%), Gaps = 11/182 (6%) Query: 204 PKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLA 263 +D+ ++G++++ HP M +KN +++L+ SLEY+K E + + + ++ Sbjct: 1 MEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRIL 60 Query: 264 ASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRR 323 E +++ + II LK V+I +KGI ++ + N+ A+RR ++ Sbjct: 61 QMEEEYIHQLCEDIIQLKP----------DVVITEKGISDLAQHYLMRANVTAIRRVRKT 110 Query: 324 NMERLQLVTGGEAQNSVEDLSPQILGF-SGLVYQETIGEEKFTYVTENTDPKSCTILIKG 382 + R+ G + E+L +G +GL+ + IG+E FT++T+ DPK+CTIL++G Sbjct: 111 DNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRG 170 Query: 383 ST 384 ++ Sbjct: 171 AS 172 >5DA8-A nrPDB Length = 545 Score = 185 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 104/564 (18%), Positives = 199/564 (35%), Gaps = 104/564 (18%) Query: 24 TSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSP----TAVLIARA 79 + L + ++ LGP G ++ G TKDG + E+++ P A ++ Sbjct: 18 VGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREV 77 Query: 80 AAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKIS 139 A+ ++ GDGTTT L + R+ + + G P + G + A KE + L Sbjct: 78 ASKTSDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAELRNI--- 134 Query: 140 KTNLSNDREFLLQVARSSLLT--KVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIM 197 + + ++ + QV S ++ + E + + D V++V +A+ +L +VE M Sbjct: 135 -SRSISGKKEIAQVGTISANNDPEIGELIAEAMDKVGKDGVITVEEAKGMETELKVVEGM 193 Query: 198 QMQHLSPKDTTFIKGLVLDHGGRHPD-MPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSA 256 Q +G + + + + M + A +LI + + K Sbjct: 194 QFD----------RGYLSPYFVTNSETMEAELDEALILIHDKKISNMKE----------- 232 Query: 257 DQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDV-FAKHNIL 315 + L+K + + D + ++ + + A Sbjct: 233 -------------LLPILEKAAQSGRPLLIIAEDIEGEALATLVVNKLRGTLKVAAVKAP 279 Query: 316 ALRRAKRRNMERLQLVTGGEAQN-----SVEDLSPQILGFSGLVYQETIGEEKFTYVTE- 369 ++ +E + ++TGG + +E+ + LG + + TI ++ T V Sbjct: 280 GFGDRRKAMLEDIAILTGGTVISEEKGYKLENATMAYLGQAARI---TIDKDNTTIVEGK 336 Query: 370 ---------------------------------NTDPKSCTIL-IKGSTHYALAQTKDAV 395 +L I ST + + K V Sbjct: 337 GKQEEIKARINEIKGQIEKSTSDYDTEKLQERLAKLSGGVAVLKIGASTEVEMKEKKARV 396 Query: 396 RDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIP 455 D L A +++ I+ G G I ++ L A + KTGIE AL Sbjct: 397 EDALHATRAAVQEG-IVVGGGVALIRAAKGLAKAVADNED----QKTGIEIIRRALEEPL 451 Query: 456 KTLVKNSGF-DPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLR 514 + +V N+G D VL V++ D G + + G+ D +V R Sbjct: 452 RQIVANTGTTDGAVVLEKVKNAEGD---------YGFNARTEQYENLIEAGVVDPTKVTR 502 Query: 515 NAITGATGIASNLLLCDELLRAGR 538 +A+ A +AS LL + + + Sbjct: 503 SALENAASVASILLTTEAAITDVK 526 >1E0R-B nrPDB Length = 159 Score = 174 bits (442), Expect = 7e-44, Method: Composition-based stats. Identities = 46/163 (28%), Positives = 81/163 (49%), Gaps = 10/163 (6%) Query: 210 IKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKF 269 + G+++D HP MP VK+A + +L+ LE +K E ++ K A E Sbjct: 1 MNGIIVDKEKVHPGMPDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENM 60 Query: 270 VDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQ 329 + + KI + V+I QKGID M+ ++ I A+RR K+ +M++L Sbjct: 61 LREMVDKIKSVG----------ANVVITQKGIDDMAQHYLSRAGIYAVRRVKKSDMDKLA 110 Query: 330 LVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTD 372 TG ++++++S LG + V Q +GE+ T+VT + + Sbjct: 111 KATGASIVSTIDEISSSDLGTAERVEQVKVGEDYMTFVTGSKN 153 >1SJP-A nrPDB Length = 504 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 93/541 (17%), Positives = 187/541 (34%), Gaps = 101/541 (18%) Query: 50 AGNIKLTKDGKVLLTEMQIQSP----TAVLIARAAAAQDEITGDGTTTVVCLVGELLRQA 105 G +T DG + E++++ P A L+ A D++ GDGTTT L L+R+ Sbjct: 1 WGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREG 60 Query: 106 HRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDAD 165 R + G +P + G E A ++ + L + +E + A S + D Sbjct: 61 LRNVAAGANPLGLKRGIEKAVEKVTETL----LKGAKEVETKEQIAATAAISAGDQSIGD 116 Query: 166 -LTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDM 224 + E + + + V++V ++ L L + E M+ +I G + R + Sbjct: 117 LIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKG------YISGYFVTDPERQEAV 170 Query: 225 PTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEV 284 +++ Y+L+++ + K + L+K+I + Sbjct: 171 ---LEDPYILLVSSKVSTVKD------------------------LLPLLEKVIGAGKPL 203 Query: 285 CGMDPDKGFVIINQKGIDPMSLDVFAKH-NILALRRAKRRNMERLQLVTGGEAQN----- 338 + D ++ ++ + + ++ ++ + ++TGG+ + Sbjct: 204 LIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGL 263 Query: 339 SVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCT--------------------- 377 ++E+ +LG + V ++ T V D + Sbjct: 264 TLENADLSLLGKARKVVVTK---DETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREK 320 Query: 378 --------------ILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALS 423 I +T L + K + D +R +++ I+ G G + + Sbjct: 321 LQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEG-IVAGGGVTLLQAA 379 Query: 424 RYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDS 483 L L +G TG AL K + NSG +P V V + Sbjct: 380 PTLDE-----LKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAG---- 430 Query: 484 DETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKE 543 G++ G D G+ D +V R+A+ A IA L + ++ K Sbjct: 431 -----HGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKA 485 Query: 544 T 544 + Sbjct: 486 S 486 >1ASS-A nrPDB Length = 159 Score = 171 bits (433), Expect = 8e-43, Method: Composition-based stats. Identities = 47/163 (28%), Positives = 81/163 (49%), Gaps = 10/163 (6%) Query: 210 IKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKF 269 + G+V+D H MP VKNA + +++ +LE +KTE+ + S + E Sbjct: 1 MSGIVIDKEKVHSKMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNT 60 Query: 270 VDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQ 329 ++KI V++ QKGID ++ AK I A+RR K+ +ME+L Sbjct: 61 FKQMVEKIKK----------SGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLA 110 Query: 330 LVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTD 372 TG + ++DL+P +LG + V + IG+++ T+V + Sbjct: 111 KATGAKIVTDLDDLTPSVLGEAETVEERKIGDDRMTFVMGCKN 153 >5CDI-A nrPDB Length = 552 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 101/551 (18%), Positives = 198/551 (35%), Gaps = 69/551 (12%) Query: 17 AALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSP----T 72 ALK + L +V+ +GPKG +L G K+ DG + E+++ P Sbjct: 12 QALKRMQAGVDKLATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPVENIG 71 Query: 73 AVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKF 132 A L+ +AAA ++ GDGTTT L + + + + G +P + G E + + Sbjct: 72 ATLVRQAAARTNDTAGDGTTTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTVQ---EL 128 Query: 133 LDEFKISKTNLSNDREFLLQVARSSL--LTKVDADLTEVLTPIVTDAVLSVYDAQADNLD 190 + E + + + D++ L VA S T + + +++ + + V+++ + + Sbjct: 129 VKELRKMSSVVQTDKD-LANVACVSAGGNTDIGSLISDAMAKVGRTGVVTMEEGKTAEDQ 187 Query: 191 LHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPD-MPTRVKNAYVLILNVSLEYEKTEVNS 249 L VE MQ + +G + P+ M +N +L+++ + + ++ + Sbjct: 188 LVFVEGMQFE----------RGYTSPYFVTDPERMICEYENCKILLVDKKISTAR-DIIT 236 Query: 250 GFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVF 309 + L +E +++ V + V I G Sbjct: 237 ILESAIRGNYPLLIMAEE------VEQEALATLVVNKLRGTLKVVAIKAPGFGERRSSYL 290 Query: 310 AKHNILALRRAKRRNM----------------------ERLQLV----TGGEAQNSVEDL 343 IL R M ER +V T + V+ + Sbjct: 291 EDIAILTGGTVVRDEMGVSLEQATDAVLGTAAKITITKERTTVVGDGSTAADVAARVKQI 350 Query: 344 SPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVA 403 + +E + +E+ ++ I + T L + K V D L A Sbjct: 351 RNLQMQTDQDYEREKL-QERIARLSGG----VAIIQVGAQTETELKEKKLRVEDALNATR 405 Query: 404 NVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSG 463 +++ ++PG G + LS + + + G + AL K + +N+G Sbjct: 406 AAVEEG-VVPGGGCTLLRLSEKVDVIKRRMTDPE--QQMGADIIKRALCYPIKLIAQNAG 462 Query: 464 FDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGI 523 + V+ V LD G + + GI D +V+R ++ A + Sbjct: 463 VNGSVVMNEVMKNLDRPH-------YGYNAATDSFENLMETGIIDPSKVVRCSMENAVSV 515 Query: 524 ASNLLLCDELL 534 A LL D ++ Sbjct: 516 AKTFLLADVVV 526 >3LXD-A nrPDB Length = 415 Score = 43.1 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 34/216 (15%), Positives = 65/216 (30%), Gaps = 37/216 (17%) Query: 303 PMSLDVFAKHNIL---ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETI 359 P+S + A+ +R A+ + +++ G E + LG + Sbjct: 52 PLSKEYLAREKTFERICIRPAQFWEDKAVEMKLGAEVVSLDPAAHTVKLGDGSAIEY--- 108 Query: 360 GEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFY 419 K + T + + + +A+ +DA D L A + ++ G G Sbjct: 109 --GKLIWATGGDPRRLSCVGADLAGVHAVRTKEDA--DRLMAELDAGAKNAVVIGGGYIG 164 Query: 420 IALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDD 479 + + L +N L +P+ L + +G + L+ Sbjct: 165 LEAAAVLTKFGVNVTL---------------LEALPRVLARVAG----EALSEFYQAEHR 205 Query: 480 AQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRN 515 A GVDL G + D V Sbjct: 206 AH--------GVDLRTGAAMDCIEGDGTKVTGVRMQ 233 >3E0V-A nrPDB Length = 539 Score = 36.9 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 27/65 (41%), Gaps = 11/65 (16%) Query: 23 VTSAEGLQSVLETNLGPKGTLKML---------VDGAGNIKLTKDGKVLLT-EMQIQSPT 72 + SAE + + LGPKG M+ V +I DG ++ ++ ++ P Sbjct: 254 IRSAEQVGD-VRKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPA 312 Query: 73 AVLIA 77 ++ Sbjct: 313 EKVVV 317 >2GJN-A nrPDB Length = 328 Score = 36.9 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 13/86 (15%), Positives = 30/86 (34%), Gaps = 2/86 (2%) Query: 361 EEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNII--PGAGAF 418 +F E + I+ + + ++R+ R N + + + GA Sbjct: 201 GTRFLATRECPIHPAVKAAIRAADERSTDLIMRSLRNTARVARNAISQEVLAIEARGGAG 260 Query: 419 YIALSRYLRSANMNKLGAKGKTKTGI 444 Y ++ + ++ +G T GI Sbjct: 261 YADIAALVSGQRGRQVYQQGDTDLGI 286 >3FTB-A nrPDB Length = 361 Score = 34.6 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 24/128 (18%), Positives = 42/128 (32%), Gaps = 20/128 (15%) Query: 406 LKDKNIIPGAGAFY-IALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGF 464 LKD I+ G GA I LS L + + I A + V+ L +N Sbjct: 76 LKDIGIVLGNGASEIIELSISL--FEKILIIVPSYAEYEINAKKHGVSVVFSYLDENMCI 133 Query: 465 DPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIA 524 D D+++ ++D + G+ + I + + A Sbjct: 134 DYEDIISKIDDVDSVIIGNPNNPNGGL--------INKEKFI--------HVLKLAEEKK 177 Query: 525 SNLLLCDE 532 ++ DE Sbjct: 178 KTII-IDE 184 >2IOU-G nrPDB Length = 535 Score = 32.3 bits (72), Expect = 0.60, Method: Composition-based stats. Identities = 19/124 (15%), Positives = 43/124 (34%), Gaps = 15/124 (12%) Query: 304 MSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEK 363 ++ + + R ++R +V GG +++ L P+ L S +V +G+ Sbjct: 118 IADSTLQGAGGVRVERGANVTVQRSTIVDGGLHIGTLQPLQPEDLPPSRVV----LGDTS 173 Query: 364 FTYVTENTDPKSCTILIKGSTHYALAQTK---------DAVRDGLRAVANVLKDKNIIPG 414 T V + P + ++ G+ + A+ + + + P Sbjct: 174 VTAVPASGAPAAVSVF--GANELTVDGGHITGGRAAGVAAMDGAIVHLQRATIRRGDAPA 231 Query: 415 AGAF 418 GA Sbjct: 232 GGAV 235 >6ESQ-A nrPDB Length = 392 Score = 32.3 bits (72), Expect = 0.61, Method: Composition-based stats. Identities = 20/73 (27%), Positives = 31/73 (42%), Gaps = 1/73 (1%) Query: 160 TKVDADLTEVLTPIVTDA-VLSVYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHG 218 TK + ++ +A V ++ DA D D+ + I M I L+ DH Sbjct: 12 TKFGELWEDSFRDLIVEAGVKAIKDANVDGGDIDAMYIGNMSGGLFVGQEHIASLIADHA 71 Query: 219 GRHPDMPTRVKNA 231 G +P TRV+ A Sbjct: 72 GLNPVPCTRVEAA 84 >1Z2N-X nrPDB Length = 324 Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 40/106 (37%), Gaps = 15/106 (14%) Query: 213 LVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDA 272 L L+ H M +R + +N L + + F S ++ +L S++ + Sbjct: 85 LFLESSAIHDMMSSREE------INALLIKNNIPIPNSFSVKSKEEVIQLLQSKQLILPF 138 Query: 273 KLKKIIDLKNEVCGMDPDKGFVIINQKGIDP-----MSLDVFAKHN 313 I+ +N + + +++ Q+GID + +N Sbjct: 139 ----IVKPENAQGTFNAHQMKIVLEQEGIDDIHFPCLCQHYINHNN 180 >1UF2-K nrPDB Length = 506 Score = 30.8 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 28/68 (41%), Gaps = 7/68 (10%) Query: 288 DPDKGFVIINQKGIDPMSLDVFAKHNILA-------LRRAKRRNMERLQLVTGGEAQNSV 340 + + + + GI +SLD IL +RR+ + +L G + V Sbjct: 432 NKKHSLLQLTKNGISVVSLDELTDAGILVESTGPDRVRRSPKVLANKLSSFKGRKVTLDV 491 Query: 341 EDLSPQIL 348 +++S + L Sbjct: 492 DNMSTEAL 499 >3PLN-A nrPDB Length = 424 Score = 30.4 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 22/55 (40%), Gaps = 2/55 (3%) Query: 95 VCLVGELLRQAHRFIQEGVHPRIITDGFEIAR-KESMKFLDEFKISKTNLSNDRE 148 V E LR+ R + + +HP I G AR + L E I + + + Sbjct: 172 VIFSPEFLREG-RALYDNLHPSRIVIGERSARAERFADLLKEGAIKQDIPTLFTD 225 >3L6X-A nrPDB Length = 584 Score = 30.4 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 7/89 (7%), Positives = 31/89 (34%), Gaps = 11/89 (12%) Query: 306 LDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQ-ILGFSGLVYQETIGEEK- 363 + +++ + + ++ +L+ + ++ + LG G + + G ++ Sbjct: 73 QHLCYRNDKV------KTDVRKLKGI--PVLVGLLDHPKKEVHLGACGALKNISFGRDQD 124 Query: 364 -FTYVTENTDPKSCTILIKGSTHYALAQT 391 + + L++ + L + Sbjct: 125 NKIAIKNCDGVPALVRLLRKARDMDLTEV 153 >3MY9-A nrPDB Length = 377 Score = 30.0 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 22/56 (39%), Gaps = 2/56 (3%) Query: 436 AKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGV 491 + + FA AL L S FD +D++ +V + DA + G+ Sbjct: 226 VPRRHLDAMAGFAAALDTP--ILADESCFDAVDLMEVVRRQAADAISVKIMKCGGL 279 >1S5J-A nrPDB Length = 847 Score = 29.6 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 35/79 (44%) Query: 222 PDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLK 281 P MP VKN + + +SL+ + E F S + ++A + ++ KI + Sbjct: 135 PGMPYVVKNGKLESVYLSLDEKDVEEIKKAFADSDEMTRQMAVDWLPIFETEIPKIKRVA 194 Query: 282 NEVCGMDPDKGFVIINQKG 300 ++ P KG + +QK Sbjct: 195 IDIEVYTPVKGRIPDSQKA 213 >2GF2-A nrPDB Length = 296 Score = 28.8 bits (63), Expect = 5.9, Method: Composition-based stats. Identities = 15/108 (13%), Positives = 39/108 (36%), Gaps = 1/108 (0%) Query: 107 RFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADL 166 + + + +P II D F A KE ++ S +++ + ++ + +S+ Sbjct: 17 KNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSG 76 Query: 167 TEVLTPIVTDAVLSVYDAQADN-LDLHMVEIMQMQHLSPKDTTFIKGL 213 + V L + + D + + + ++ D G+ Sbjct: 77 ANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGV 124 >1V72-A nrPDB Length = 356 Score = 28.8 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 12/32 (37%), Gaps = 1/32 (3%) Query: 63 LTEMQIQSPTAVL-IARAAAAQDEITGDGTTT 93 M + P A L I R E GD TT Sbjct: 109 AKLMTVDGPAAKLDIVRLRERTREKVGDVHTT 140 >3I4E-A nrPDB Length = 439 Score = 28.5 bits (62), Expect = 7.3, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 22/45 (48%) Query: 342 DLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHY 386 + + GF+ + +Q +G F VT+ + ++ T + GST Sbjct: 385 EFAAADKGFTAVKHQREVGTGYFDAVTQTVEREASTTALHGSTED 429 >4KRZ-A nrPDB Length = 519 Score = 28.5 bits (62), Expect = 8.3, Method: Composition-based stats. Identities = 12/65 (18%), Positives = 27/65 (41%), Gaps = 11/65 (16%) Query: 23 VTSAEGLQSVLETNLGPKGTLKMLVDGAGN---------IKLTKDGKVLLT-EMQIQSPT 72 + +AE +Q + LG KG +++ N I DG ++ ++ ++ P Sbjct: 234 IRTAEQVQE-VREALGEKGKDILIISKIENHQGVQNIDGIIEASDGIMVARGDLGVEIPA 292 Query: 73 AVLIA 77 ++ Sbjct: 293 EKVVV 297 >3GEE-A nrPDB Length = 476 Score = 28.1 bits (61), Expect = 9.7, Method: Composition-based stats. Identities = 12/65 (18%), Positives = 21/65 (32%), Gaps = 10/65 (15%) Query: 58 DGKVLLTEMQIQSPTAVLIARAAAAQDEIT---------GDGTTTVVCLVGELLRQAHRF 108 D + E++ P A + A D DGT T V + L Sbjct: 329 DELTEIRELKAAHPAAKFLT-VANKLDRAANADALIRAIADGTGTEVIGISALNGDGIDT 387 Query: 109 IQEGV 113 +++ + Sbjct: 388 LKQHM 392 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.137 0.345 Lambda K H 0.267 0.0420 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,428,358 Number of Sequences: 36641 Number of extensions: 750134 Number of successful extensions: 2645 Number of sequences better than 10.0: 63 Number of HSP's better than 10.0 without gapping: 83 Number of HSP's successfully gapped in prelim test: 30 Number of HSP's that attempted gapping in prelim test: 2238 Number of HSP's gapped (non-prelim): 124 length of query: 546 length of database: 10,336,785 effective HSP length: 102 effective length of query: 444 effective length of database: 6,599,403 effective search space: 2930134932 effective search space used: 2930134932 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.5 bits)