BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P39078 (528 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5GW4-d nrPDB 1065 0.0 4B2T-D nrPDB 645 0.0 3J1C-A nrPDB 351 5e-97 1Q3S-A nrPDB 349 2e-96 4XCI-A nrPDB 336 1e-92 1A6E-A nrPDB 334 5e-92 5UYZ-A nrPDB 333 1e-91 3J1E-A nrPDB 328 4e-90 4XCG-B nrPDB 328 4e-90 3RUW-A nrPDB 327 7e-90 4V8R-AE nrPDB 322 2e-88 3AQ1-B nrPDB 315 4e-86 1A6D-B nrPDB 311 6e-85 3IYF-A nrPDB 308 4e-84 4B2T-A nrPDB 266 1e-71 4B2T-G nrPDB 265 4e-71 4B2T-H nrPDB 265 4e-71 5GW5-g nrPDB 237 8e-63 5GW4-h nrPDB 234 7e-62 4V8R-AB nrPDB 232 4e-61 4V94-A nrPDB 229 2e-60 4B2T-B nrPDB 219 3e-57 4B2T-Z nrPDB 197 1e-50 4B2T-Q nrPDB 192 3e-49 5GW5-z nrPDB 191 7e-49 5GW5-q nrPDB 189 3e-48 4V8R-AG nrPDB 147 8e-36 5X9V-A nrPDB 137 1e-32 1E0R-B nrPDB 69 3e-12 1ASS-A nrPDB 68 1e-11 1IOK-A nrPDB 55 6e-08 4AAR-A nrPDB 55 7e-08 4V4O-A nrPDB 51 1e-06 5DA8-A nrPDB 50 2e-06 4PJ1-A nrPDB 47 2e-05 1GN1-A nrPDB 47 3e-05 1SJP-A nrPDB 44 2e-04 5CDI-A nrPDB 35 0.10 2B7M-A nrPDB 32 0.64 4V4N-AO nrPDB 30 2.2 4PHT-A nrPDB 29 4.8 4KSS-A nrPDB 28 6.6 1P9R-A nrPDB 28 8.2 5JY6-A nrPDB 28 8.7 3LL9-A nrPDB 28 9.7 >5GW4-d nrPDB Length = 528 Score = 1065 bits (2754), Expect = 0.0, Method: Compositional matrix adjust. Identities = 528/528 (100%), Positives = 528/528 (100%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND Sbjct: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 Query: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTII 120 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTII Sbjct: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTII 120 Query: 121 ADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLK 180 ADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLK Sbjct: 121 ADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLK 180 Query: 181 ISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQ 240 ISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQ Sbjct: 181 ISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQ 240 Query: 241 ISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDL 300 ISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDL Sbjct: 241 ISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDL 300 Query: 301 ALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKI 360 ALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKI Sbjct: 301 ALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKI 360 Query: 361 VRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIE 420 VRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIE Sbjct: 361 VRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIE 420 Query: 421 ISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND 480 ISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND Sbjct: 421 ISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND 480 Query: 481 GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR Sbjct: 481 GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 >4B2T-D nrPDB Length = 542 Score = 645 bits (1664), Expect = 0.0, Method: Compositional matrix adjust. Identities = 312/524 (59%), Positives = 425/524 (81%), Gaps = 10/524 (1%) Query: 9 ATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQM 68 + +++++KP ++R +NI AA++VADAIRTSLGPKGMDKMI+ +G++ I+NDG TILKQM Sbjct: 25 SAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQM 84 Query: 69 AILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAA 128 +LHP ARMLVE+S AQD EAGDGTTSVVI+ G+LL + +LL KGIHPTII++SFQ A Sbjct: 85 QVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKAL 144 Query: 129 KRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDE-NSK 187 ++ ++IL +M V LSDRE L+ +A+TSL+SK+VSQYSS L+P++VD+V+K+ D + Sbjct: 145 EKGIEILTDMSRPVELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATAT 204 Query: 188 NVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPD 247 +VDL DI++VKK+GGTIDD E+++G+VLTQ S G TR EKAKIGLIQF +S PK D Sbjct: 205 SVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANS--GITRVEKAKIGLIQFCLSAPKTD 262 Query: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSK 307 +N I+V+DY QMD++L+EERAY+LN+ K+IKK CNVLLIQKSILRDA++DLALHFL+K Sbjct: 263 MDNQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNK 322 Query: 308 LNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGS-KIVRVTGI 366 + IMVVKDIERE+IEF+ K +G KP+A ++ FT D LGSA+L EE+ +GS K++++TG Sbjct: 323 MKIMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSGKLIKITGC 382 Query: 367 RNNNARP--TVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRR 424 A P TV++V+RG+N ++I+E ERS+HDALCVIRCLVK+R LIAGGGAPEIE++ R Sbjct: 383 ----ASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALR 438 Query: 425 LSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISV 484 L++ +R++ G++++ + FA A+EVIP+TLAENAGLN I VTELR++H GE GI+V Sbjct: 439 LTEYSRTLSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINV 498 Query: 485 RRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 R+ G +N EE ++QP+LVS SA+TLA+E V+SIL+IDD+ +R Sbjct: 499 RKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVNTR 542 >3J1C-A nrPDB Length = 563 Score = 351 bits (900), Expect = 5e-97, Method: Compositional matrix adjust. Identities = 207/539 (38%), Positives = 331/539 (61%), Gaps = 25/539 (4%) Query: 1 MSAKVPSNATFK---NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIII 57 MS+ VP FK ++ ++ K NI+AAR++A+ +R+SLGPKG+DKM+ S G++ I Sbjct: 1 MSSGVPV-LLFKEGTSRNSGRDALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTI 59 Query: 58 SNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHP 117 +NDG TI+K+M I HP A++LVE + AQDSE GDGTTS V+L G L AE L+++ IHP Sbjct: 60 TNDGATIVKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHP 119 Query: 118 TIIADSFQSAAKRSVDILLEMCHKVSLSD------REQLVRAASTSLSSKIVSQYSSF-- 169 TII + F+ A +S+++L ++ KV +SD R+ L + T++SSK +++ Sbjct: 120 TIIIEGFKKAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNK 179 Query: 170 LAPLAVDSVLKISD---ENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGP 226 + + +D+V +++ + NV L+ I++ KK GGTI+D+++I G+VL + + AG P Sbjct: 180 IMDIVIDAVTTVAEPLPDGGYNVSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVVH-AGMP 238 Query: 227 TRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVL 286 R EKAKI ++ + KP+ I + Q+ L EE YL ++ K+ NV+ Sbjct: 239 RRVEKAKIAVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGANVV 298 Query: 287 LIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGS 346 + QK I +D+A HFL+K I+ V+ ++R +IE L K LG + I+ I+ T + LG Sbjct: 299 ICQKGI-----DDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGY 353 Query: 347 ADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVK 406 A+LVEE K+V + G +N A V++++RG+N+M +DE ERS++DAL +R ++ Sbjct: 354 AELVEERKVGNDKMVFIEGAKNPKA---VNILLRGSNDMALDEAERSINDALYSLRNILM 410 Query: 407 ERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVV 466 E ++ GGGA E+E+S RL + ARS+ G + + +A ALE IP LAE AGL I + Sbjct: 411 EPYIVPGGGAIELELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISAL 470 Query: 467 TELRSKHENGELNDGISVRRSGTT-NTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 +LR++H G N G+ V + Y ++++P+ V+ + A+E SI++IDD+ Sbjct: 471 MDLRARHAKGLTNCGVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDL 529 >1Q3S-A nrPDB Length = 548 Score = 349 bits (895), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 192/513 (37%), Positives = 323/513 (62%), Gaps = 11/513 (2%) Query: 18 QEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARM 77 ++ ++ NI+AAR +A+ +RT+LGPKGMDKM+ S G+I+++ND TIL ++ + HP A+M Sbjct: 22 RDAQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDCATILDKIDLQHPAAKM 81 Query: 78 LVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLE 137 +VEV+ QD EAGDGTT+ V++ G LL AE LL++ IHP+II + AA+++ +IL E Sbjct: 82 MVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSIIIKGYALAAEKAQEILDE 141 Query: 138 MCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKN--VDLNDIR 195 + +V D E L++ A+TS++ K + LA LAV++V +++++ VDL++I+ Sbjct: 142 IAIRVDPDDEETLLKIAATSITGKNAESHKELLAKLAVEAVKQVAEKKDGKYVVDLDNIK 201 Query: 196 LVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVN 255 KK G ++++E++ GVV+ + + P R E AKI LI + K +T+ I + Sbjct: 202 FEKKAGEGVEESELVRGVVIDKEVVHPR-MPKRVENAKIALINEALEVKKTETDAKINIT 260 Query: 256 DYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKD 315 Q+ L++E L ++ I + NV+ +QK I +DLA H+L+K IM V+ Sbjct: 261 SPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGI-----DDLAQHYLAKYGIMAVRR 315 Query: 316 IEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTV 375 +++ ++E L+K G K + +++ T + LG A++VEE G ++ V G +N A V Sbjct: 316 VKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAGENMIFVEGCKNPKA---V 372 Query: 376 SVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGV 435 +++IRG +IDE ER+L DA+ V++ ++++ ++ GGAPEIE++ RL + A+ + G Sbjct: 373 TILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIELAIRLDEYAKQVGGK 432 Query: 436 QAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEE 495 +A + FA AL++IP TLAENAGL++++++ ++ S+H+N L GI V + E+ Sbjct: 433 EALAIENFADALKIIPKTLAENAGLDTVEMLVKVISEHKNRGLGIGIDVFEGKPADMLEK 492 Query: 496 HILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 I++P+ V AI ASE ILRIDD+ ++ Sbjct: 493 GIIEPLRVKKQAIKSASEAAIMILRIDDVIAAK 525 >4XCI-A nrPDB Length = 559 Score = 336 bits (861), Expect = 1e-92, Method: Compositional matrix adjust. Identities = 192/513 (37%), Positives = 319/513 (62%), Gaps = 21/513 (4%) Query: 24 NIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVSA 83 NI+AA+++A+ +R+SLGPKG+DKM+ S G++ I+NDG TI+K M I HP A++LVE + Sbjct: 24 NILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIVKDMEIQHPAAKLLVEAAK 83 Query: 84 AQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVS 143 AQD+E GDGTTS V+L GALL AE LL++ IHPTII + ++ A +++++L ++ ++ Sbjct: 84 AQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYKKAYNKALELLPQLGTRID 143 Query: 144 LSD------REQLVRAASTSLSSKIVSQYSSF--LAPLAVDSVLKISD---ENSKNVDLN 192 + D R+ L + A T+L+SK +++ + + + +D+++ +++ NV L+ Sbjct: 144 IKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIIDMVIDAIVNVAEPLPNGGYNVSLD 203 Query: 193 DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNI 252 I++ KK GG+I+D+ ++ G+VL + + G P R KAKI ++ + KP+ I Sbjct: 204 LIKIDKKKGGSIEDSVLVKGLVLDKEVVHP-GMPRRVTKAKIAVLDAALEVEKPEISAKI 262 Query: 253 IVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMV 312 + Q+ L EE YL ++ K+ NV++ QK I +D+A HFL+K I+ Sbjct: 263 SITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKGI-----DDIAQHFLAKKGILA 317 Query: 313 VKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNAR 372 V+ ++R +IE L K LG + I+ I+ T + LG A+LVEE K+V + G +N A Sbjct: 318 VRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRVGNDKMVFIEGAKNLKA- 376 Query: 373 PTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSM 432 V++++RG+N+M +DE ERS++DAL +R ++ E ++ GGGA E+E++ +L + ARS+ Sbjct: 377 --VNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGGGAIELELAMKLREYARSV 434 Query: 433 EGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTT-N 491 G + + FA ALE IP LAE AGL +I + +LR++H G N G+ V + Sbjct: 435 GGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAKGLSNTGVDVIGGKIVDD 494 Query: 492 TYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 Y +I++P+ V + + A+E +IL+IDD+ Sbjct: 495 VYALNIIEPIRVKSQVLKSATEAATAILKIDDL 527 >1A6E-A nrPDB Length = 545 Score = 334 bits (857), Expect = 5e-92, Method: Compositional matrix adjust. Identities = 200/519 (38%), Positives = 319/519 (61%), Gaps = 17/519 (3%) Query: 14 KEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHP 73 +E+ + ++ NI AA+++ADA+RT+LGPKGMDKM+ S G+IIISNDG TILK+M + HP Sbjct: 17 REQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISNDGATILKEMDVEHP 76 Query: 74 VARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVD 133 A+M+VEVS AQD+ GDGTT+ V+L+G LL AE LL++G+HPT+I++ ++ A + Sbjct: 77 TAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVISNGYRLAVNEARK 136 Query: 134 ILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPL---AVDSVLKISDENSKNVD 190 I+ E+ K +D L + A T+LS K + FLA L AV++V ++ D + VD Sbjct: 137 IIDEIAEKS--TDDATLRKIALTALSGKNTGLSNDFLADLVVKAVNAVAEVRDGKTI-VD 193 Query: 191 LNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTEN 250 +I++ KK GG+++DT+ I G+V+ + + S P + AKI LI + K + E Sbjct: 194 TANIKVDKKNGGSVNDTQFISGIVIDKEKVHSK-MPDVVKNAKIALIDSALEIKKTEIEA 252 Query: 251 NIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNI 310 + ++D ++ L +E + +KIKK+ NV+L QK I +D+A H+L+K I Sbjct: 253 KVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVVLCQKGI-----DDVAQHYLAKEGI 307 Query: 311 MVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNN 370 V+ +++ ++E L+K G K + D++ T LG A+ VEE ++ V G +N Sbjct: 308 YAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVEERKIGDDRMTFVMGCKNPK 367 Query: 371 ARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERG-LIAGGGAPEIEISRRLSKEA 429 A VS++IRG + ++ E ER+L+DA+ V+ + KE G + GGGA E E++ RL+K A Sbjct: 368 A---VSILIRGGTDHVVSEVERALNDAIRVV-AITKEDGKFLWGGGAVEAELAMRLAKYA 423 Query: 430 RSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGT 489 S+ G + + FA ALE+IP TLAENAG++ I + +L++ E G ++ G+ + +G Sbjct: 424 NSVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADDEKGRISVGVDLDNNGV 483 Query: 490 TNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + + ++ P+ V T A+ A E ILRIDD+ S+ Sbjct: 484 GDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASK 522 >5UYZ-A nrPDB Length = 541 Score = 333 bits (854), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 189/512 (36%), Positives = 314/512 (61%), Gaps = 16/512 (3%) Query: 19 EVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARML 78 E K++I+AA++VA+ +RTSLGP G+DKM+ G++ ++NDG TIL M + H +A+++ Sbjct: 32 EALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLM 91 Query: 79 VEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEM 138 VE+S +QD E GDGTT VV+L GALL AE+LL++GIHP IAD ++ AA+ +++ L ++ Sbjct: 92 VELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIERLDKI 151 Query: 139 CHK--VSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRL 196 V + D E L++ A T+L SK+V+ +A +AV++VL ++D ++VD I++ Sbjct: 152 SDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKV 211 Query: 197 VKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVND 256 KVGG ++DT++I GV++ + P + E AKI ++ PPKP T++ + V Sbjct: 212 EGKVGGRLEDTKLIKGVIVDKD-FSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTS 270 Query: 257 YRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDI 316 + K E+ + ++IK+ N+ + Q +D A H L + N+ V+ + Sbjct: 271 VEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGF-----DDEANHLLLQNNLPAVRWV 325 Query: 317 EREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEID--SDGSKIVRVTGIRNNNARPT 374 EIE ++ G + + T ++LG A LV+EI + K++ + +N+ A Sbjct: 326 GGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRA--- 382 Query: 375 VSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEG 434 V++ IRG N MII+E +RSLHDALCVIR L+++ ++ GGGA EI + +S+EA Sbjct: 383 VTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPT 442 Query: 435 VQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND--GISVRRSGTTNT 492 ++ + + FA ALEVIP L+EN+G+N I+ +TE+R++ E+N GI GT + Sbjct: 443 LEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVK-EMNPALGIDCLHKGTNDM 501 Query: 493 YEEHILQPVLVSTSAITLASECVKSILRIDDI 524 ++H+++ ++ I+LA++ V+ IL+IDDI Sbjct: 502 KQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 >3J1E-A nrPDB Length = 553 Score = 328 bits (841), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 188/511 (36%), Positives = 313/511 (61%), Gaps = 14/511 (2%) Query: 18 QEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARM 77 +E +ANI A ++V +A++++ GP+GMDKM+ S G+I I+NDG TIL +M + HP A++ Sbjct: 29 KEAVRANIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQHPAAKL 88 Query: 78 LVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLE 137 LV+++ QD E DGT + VI +G L+ AE LL K +HPTII ++ A + ++ + E Sbjct: 89 LVQIAKGQDEETADGTKTAVIFSGELVKKAEDLLYKDVHPTIIISGYKKAEEVALQTIQE 148 Query: 138 MCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD--ENSKNVDLNDIR 195 + VS++D + L + A TSLSSK V+ ++A + V +V ++++ + VDL++I+ Sbjct: 149 LAQTVSINDTDLLRKIAMTSLSSKAVAGAREYIADIVVKAVTQVAELRGDKWYVDLDNIQ 208 Query: 196 LVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVN 255 +VKK GG+I+DT+++ G+V+ + + G P R E AKI LI + KP+ + I +N Sbjct: 209 IVKKAGGSINDTQLVYGIVVDKEVVHP-GMPKRLENAKIALIDASLEVEKPELDAEIRIN 267 Query: 256 DYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKD 315 D QM K L EE + KI NV++ QK I +++A +L+K ++ V+ Sbjct: 268 DPTQMQKFLDEEENLIKEKVDKILATGANVIICQKGI-----DEVAQSYLAKKGVLAVRR 322 Query: 316 IEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTV 375 ++ ++E L++ G + +++I+ +E LG A L+EE K+V V G +N ++ Sbjct: 323 AKKSDLEKLARATGGRVVSNIDEISEQDLGYASLIEERKVGEDKMVFVEGAKNPK---SI 379 Query: 376 SVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGV 435 S++IRG ++DETER+L DAL + ++K+ IAGGGA EIEI+++L K A + G Sbjct: 380 SILIRGGLERLVDETERALRDALGTVADVIKDGRAIAGGGAVEIEIAKKLRKYAPQVGGK 439 Query: 436 QAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND--GISVRRSGTTNTY 493 + + +A+ALE + + L ENAG + I ++ +LRS HEN E N GI + + + Sbjct: 440 EQLAVEAYANALESLVSILIENAGFDPIDLLMKLRSTHEN-ENNKWYGIDLYAGQPVDMW 498 Query: 494 EEHILQPVLVSTSAITLASECVKSILRIDDI 524 ++ +++P LV +AI A+E +LRIDD+ Sbjct: 499 QKGVIEPALVKMNAIKAATEAATLVLRIDDV 529 >4XCG-B nrPDB Length = 557 Score = 328 bits (840), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 191/511 (37%), Positives = 312/511 (61%), Gaps = 14/511 (2%) Query: 18 QEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARM 77 +E +ANI A +++ +A++++ GP+GMDKM+ S G+I I+NDG TIL +M + HP ++ Sbjct: 31 KEALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQHPTGKL 90 Query: 78 LVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLE 137 LV+++ QD E DGT + VIL G L AE LL K IHPTII ++ A + ++ + E Sbjct: 91 LVQIAKGQDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVSGYKKAEEIALKTIQE 150 Query: 138 MCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD--ENSKNVDLNDIR 195 + V+++D + L + A TSL SK V+ +LA L V +V ++++ + VDL++++ Sbjct: 151 IAQPVTINDTDVLRKVALTSLGSKAVAGAREYLADLVVKAVAQVAELRGDKWYVDLDNVQ 210 Query: 196 LVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVN 255 +VKK GG+++DT+++ G+V+ + + G P R E AKI L+ + KP+ + I +N Sbjct: 211 IVKKHGGSVNDTQLVYGIVVDKEVVHP-GMPKRIENAKIALLDASLEVEKPELDAEIRIN 269 Query: 256 DYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKD 315 D QM K L+EE L KI NV++ QK I +++A H+L+K I+ V+ Sbjct: 270 DPTQMHKFLEEEENILKEKVDKIAATGANVVICQKGI-----DEVAQHYLAKKGILAVRR 324 Query: 316 IEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTV 375 ++ ++E L++ G + I++I+ T LG A LVEE K+V V G +N +V Sbjct: 325 AKKSDLEKLARATGGRVISNIDELTSQDLGYAALVEERKVGEDKMVFVEGAKNPK---SV 381 Query: 376 SVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGV 435 S++IRG ++DETER+L DAL + ++++ +AGGGA EIEI++RL K A + G Sbjct: 382 SILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAVEIEIAKRLRKYAPQVGGK 441 Query: 436 QAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND--GISVRRSGTTNTY 493 + + +A+A+E + LAENAGL+ I + +LRS HEN E N G+++ + + Sbjct: 442 EQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLHEN-ETNKWYGLNLFTGNPEDMW 500 Query: 494 EEHILQPVLVSTSAITLASECVKSILRIDDI 524 + +++P LV +A+ A+E V +LRIDDI Sbjct: 501 KLGVIEPALVKMNAVKAATEAVTLVLRIDDI 531 >3RUW-A nrPDB Length = 543 Score = 327 bits (838), Expect = 7e-90, Method: Compositional matrix adjust. Identities = 182/508 (35%), Positives = 315/508 (62%), Gaps = 11/508 (2%) Query: 18 QEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARM 77 ++ ++ NI+A R +A+ +R++LGPKGMDKM+ G+++++NDG TIL++M++ HP A+M Sbjct: 18 RDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHPAAKM 77 Query: 78 LVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLE 137 L+EV+ Q+ E GDGTT+ V++ G LL AE LL++ +HPTI+ +Q+AA+++ ++L Sbjct: 78 LIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQKAQELLKT 137 Query: 138 MCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLV 197 + +V D+E L + A TS++ K + LA + V++V + D+ K VD + I++ Sbjct: 138 IACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEGK-VDKDLIKIE 196 Query: 198 KKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDY 257 KK G +IDDTE+I GV++ + + SA P + AKI L+ I + +T+ I + D Sbjct: 197 KKSGASIDDTELIKGVLVDKERV-SAQMPKKVTDAKIALLNCAIEIKETETDAEIRITDP 255 Query: 258 RQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIE 317 ++ + +++E L ++ +IK + NVL QK I +DLA H+L+K I+ + ++ Sbjct: 256 AKLMEFIEQEEKMLKDMVAEIKASGANVLFCQKGI-----DDLAQHYLAKEGIVAARRVK 310 Query: 318 REEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSV 377 + ++E L+K G IA I + LG A LVEE G ++ V ++ A V++ Sbjct: 311 KSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEERKISGDSMIFVEECKHPKA---VTM 367 Query: 378 VIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQA 437 +IRG +I+E R++ DA+ V+ C +++ +++GGG+ E+E+S +L + A + G + Sbjct: 368 LIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAEGISGREQ 427 Query: 438 FIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKH-ENGELNDGISVRRSGTTNTYEEH 496 + FA ALEVIP TLAENAGL++I+++ ++R+ H NG G++V + E Sbjct: 428 LAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGAVEDMCENG 487 Query: 497 ILQPVLVSTSAITLASECVKSILRIDDI 524 +++P+ V T AI A+E + +LRIDD+ Sbjct: 488 VVEPLRVKTQAIQSAAESTEMLLRIDDV 515 >4V8R-AE nrPDB Length = 562 Score = 322 bits (826), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 187/526 (35%), Positives = 315/526 (59%), Gaps = 16/526 (3%) Query: 12 KNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAIL 71 K ++ E +K++I+AARSVA I+TSLGP+G+DK++ + GEI I+NDG TIL QM + Sbjct: 38 KKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELD 97 Query: 72 HPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRS 131 + +A++LV++S +QD E GDGTT VV+L ALL A L+ KGIHP IA+ F AAK + Sbjct: 98 NEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLA 157 Query: 132 VDILLEMCHKVSLSD----REQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSK 187 + L E C +S S+ R+ L+RAA TSL SKIVS+ A +AV++V+ + D++ K Sbjct: 158 ISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRK 217 Query: 188 NVDLNDIRLVKKVGGTIDDTEMIDGVVL----TQTAIKSAGGPTR-KEKAKIGLIQFQIS 242 +VD + I++ +VGG+I D+++I+GV+L + + P + K+ ++ Sbjct: 218 DVDFDLIKMQGRVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPFE 277 Query: 243 PPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLAL 302 PPKP T++ + ++ + K+ E+ + +KKA +V++ Q +D A Sbjct: 278 PPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQWGF-----DDEAN 332 Query: 303 HFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVR 362 H L + ++ V+ + +E+E ++ + + + ++D+LG+ + E + G+ R Sbjct: 333 HLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEF-GTTKDR 391 Query: 363 VTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEIS 422 + I + TV+ +RG+N MI+DE ER+LHD+LCV+R LVK+ ++ GGGA E+ +S Sbjct: 392 MLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGGAAEVTMS 451 Query: 423 RRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGEL-NDG 481 +S+EA G+ + ++ FA AL+ IP TLAEN+GL+ I ++ L+SK ++ N G Sbjct: 452 LAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQLKEKISNIG 511 Query: 482 ISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 + G+ + E ++ P + I LA++ + IL+ID++ S Sbjct: 512 VDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIIS 557 >3AQ1-B nrPDB Length = 500 Score = 315 bits (806), Expect = 4e-86, Method: Compositional matrix adjust. Identities = 176/485 (36%), Positives = 292/485 (60%), Gaps = 12/485 (2%) Query: 47 MIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGA 106 M+ S G+I+I+NDG TILK+M I HP A+M+VEVS QD+E GDGTT+ +L+G LL Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 107 AERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQY 166 AE L+ KG+H TII++ ++ AA++ +IL + +S D L++ A T+++ K Y Sbjct: 61 AEELIMKGVHSTIISEGYRHAAEKCREILETITIAISPDDEAALIKIAGTAITGKGAEAY 120 Query: 167 SSFLAPLAVDSVLKISDENSKNVDLN---DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSA 223 L+ L V +V I +E + +N +I++ K+ GG+IDD+E+IDG+V+ + Sbjct: 121 KEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKER-SHP 179 Query: 224 GGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKC 283 P + E AKI L+ + K + ++ I + QM L +E + + +K+ + Sbjct: 180 NMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKVIASGA 239 Query: 284 NVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDR 343 NV+ QK I +D+A +++ K I V+ +++ +++ LSK G I D++ T + Sbjct: 240 NVVFCQKGI-----DDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTED 294 Query: 344 LGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRC 403 +G+A LVEE + G K+ VTG +N+ A V+V++ G ++D + +L+DAL V+ Sbjct: 295 VGTAGLVEEKEVRGGKMTYVTGCQNSKA---VTVLLHGGTEHVVDSLDHALNDALHVVGV 351 Query: 404 LVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSI 463 ++++ ++ GGG+ E+E+S RLS+ A +++G + +FA ALEVIP LAENAGL+ I Sbjct: 352 VIEDGKVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPI 411 Query: 464 KVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDD 523 ++ ELRS+HE G N G++V + +E +++P+ + T AI A E ILRIDD Sbjct: 412 DIMVELRSQHEKGNKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAMEATVMILRIDD 471 Query: 524 IAFSR 528 + S+ Sbjct: 472 VVASK 476 >1A6D-B nrPDB Length = 543 Score = 311 bits (796), Expect = 6e-85, Method: Compositional matrix adjust. Identities = 184/513 (35%), Positives = 312/513 (60%), Gaps = 11/513 (2%) Query: 14 KEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHP 73 +E ++ K NI AA ++++++R+SLGP+GMDKM+ S G+I+I+NDG TILK+M + HP Sbjct: 16 RESGKDAMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDGVTILKEMDVEHP 75 Query: 74 VARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVD 133 A+M+VEVS QDS GDGTT+ VI+ G LL A+ L+N+ +HPT+I++ ++ A++ + Sbjct: 76 AAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTVISEGYRMASEEAKR 135 Query: 134 ILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD--ENSKNVDL 191 ++ E+ K+ ++ L++ A TSL+SK S LA ++ ++V +++ + VD Sbjct: 136 VIDEISTKIGADEKALLLKMAQTSLNSKSASVAKDKLAEISYEAVKSVAELRDGKYYVDF 195 Query: 192 NDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENN 251 ++I++VKK GG IDDT++I+G+++ + + G P + AKI L+ + KP+ + N Sbjct: 196 DNIQVVKKQGGAIDDTQLINGIIVDKEKVHP-GMPDVVKDAKIALLDAPLEIKKPEFDTN 254 Query: 252 IIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIM 311 + + D + K L +E L + KIK NV++ QK I +D+A H+LS+ I Sbjct: 255 LRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGI-----DDMAQHYLSRAGIY 309 Query: 312 VVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNA 371 V+ +++ +++ L+K G ++ I+ + LG+A+ VE++ + VTG +N A Sbjct: 310 AVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVGEDYMTFVTGCKNPKA 369 Query: 372 RPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARS 431 VS+++RG ++DE ERS+ D+L V+ +++ AGGGA EI+ RL A+ Sbjct: 370 ---VSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAAEIAFRLRSYAQK 426 Query: 432 MEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTN 491 + G Q ++FA A+E IP LAENAGL+ I ++ +LR++H G GI+V + Sbjct: 427 IGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEHAKGNKTYGINVFTGEIED 486 Query: 492 TYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 + +++P+ V AI A+E ILRIDD+ Sbjct: 487 MVKNGVIEPIRVGKQAIESATEAAIMILRIDDV 519 >3IYF-A nrPDB Length = 521 Score = 308 bits (789), Expect = 4e-84, Method: Compositional matrix adjust. Identities = 177/508 (34%), Positives = 303/508 (59%), Gaps = 33/508 (6%) Query: 18 QEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARM 77 ++ ++ NI+A R +A+ +R++LGPKGMDKM+ G+++++NDG TIL++M++ HP A+M Sbjct: 18 RDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHPAAKM 77 Query: 78 LVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLE 137 L+EV+ Q+ E GDGTT+ V++ G LL AE LL++ +HPTI+ +Q+AA+++ ++L Sbjct: 78 LIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQKAQELLKT 137 Query: 138 MCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLV 197 + +V D+E L + A TS++ K + LA + V++V + D+ K VD + I++ Sbjct: 138 IACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEGK-VDKDLIKIE 196 Query: 198 KKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDY 257 KK G +IDDTE+I GV++ + + SA P + AKI L+ I + Sbjct: 197 KKSGASIDDTELIKGVLVDKERV-SAQMPKKVTDAKIALLNCAIEETASE---------- 245 Query: 258 RQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIE 317 L ++ +IK + NVL QK I +DLA H+L+K I+ + ++ Sbjct: 246 ------------MLKDMVAEIKASGANVLFCQKGI-----DDLAQHYLAKEGIVAARRVK 288 Query: 318 REEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSV 377 + ++E L+K G I +I+ + LG A LVEE G ++ V ++ A V++ Sbjct: 289 KSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEERKISGDSMIFVEECKHPKA---VTM 345 Query: 378 VIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQA 437 +IRG +I+E R++ DA+ V+ C +++ +++GGG+ E+E+S +L + A + G + Sbjct: 346 LIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAEGISGREQ 405 Query: 438 FIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKH-ENGELNDGISVRRSGTTNTYEEH 496 + FA ALEVIP TLAENAGL++I+++ ++R+ H NG G++V + E Sbjct: 406 LAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGAVEDMCENG 465 Query: 497 ILQPVLVSTSAITLASECVKSILRIDDI 524 +++P+ V T AI A+E + +LRIDD+ Sbjct: 466 VVEPLRVKTQAIQSAAESTEMLLRIDDV 493 >4B2T-A nrPDB Length = 556 Score = 266 bits (681), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 172/535 (32%), Positives = 287/535 (53%), Gaps = 29/535 (5%) Query: 9 ATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQM 68 + F ++ + +R N++AA S+A+ +++SLGP G+DKM+ G++ I+NDG TILK + Sbjct: 6 SVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLL 65 Query: 69 AILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAA 128 + HP A++L E++ QD E GDGTTSVVI+ LL A+ L+ + IHPT + ++ A Sbjct: 66 EVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLAC 125 Query: 129 KRSVDILLE-MCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSK 187 K +V + E + R+ L+ AA TS+SSK++ F A L VD+VL I + + Sbjct: 126 KEAVRYISENLIINTDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIR 185 Query: 188 N---VDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPP 244 +N I ++K G + ++ +I+G L + S G P R AKI + F + Sbjct: 186 GQPRYPVNSINVLKAHGRSQMESMLINGYAL-NCVVGSQGMPKRIVNAKIACLDFSLQKT 244 Query: 245 KPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHF 304 K +++ D ++D+I + E +KI NV+L I +D+ L + Sbjct: 245 KMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGI-----DDMCLKY 299 Query: 305 LSKLNIMVVKDIEREEIEFLSKGLGCKPIADI------ELFTEDRLGSA-DLVEEIDSDG 357 + M V+ + + +++ ++K G ++ + E F LG A ++V+E D Sbjct: 300 FVEAGAMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDD 359 Query: 358 SKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAP 417 I+ I+N AR + SV++RGAN+ + DE ERSLHDALCV++ +++ + ++ GGGA Sbjct: 360 ELIL----IKNTKARTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAV 415 Query: 418 EIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGE 477 E +S L A SM + EFA +L VIP TLA NA +S +V +LR+ H + Sbjct: 416 EAALSIYLENYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQ 475 Query: 478 LND--------GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 +N G+ + + + + +P +V ++ A+E +ILRIDD+ Sbjct: 476 VNPERKNLKWIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDL 530 >4B2T-G nrPDB Length = 545 Score = 265 bits (676), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 160/519 (30%), Positives = 298/519 (57%), Gaps = 20/519 (3%) Query: 14 KEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHP 73 +E ++V+ NI AA+++AD IRT LGPK M KM+ G I+++NDG+ IL+++ + HP Sbjct: 16 RESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHP 75 Query: 74 VARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVD 133 A+ ++E+S QD E GDGTTSV+IL G +L AE L + +HPT++ +++ A + Sbjct: 76 AAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMIS 135 Query: 134 ILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSV--LKISDENSKNVDL 191 L ++ V S+R+ ++ ++S+++K++S++SS +A+D+V ++ + K +D+ Sbjct: 136 TLKKISIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDI 195 Query: 192 NDIRLVKKV-GGTIDDTEMIDGVVLTQTAIKSAGGPTRK---EKAKIGLIQFQISPPKPD 247 V+K+ GG I+D+ ++ GV++ K P + + +I L+ + K + Sbjct: 196 KKYARVEKIPGGIIEDSCVLRGVMIN----KDVTHPRMRRYIKNPRIVLLDSSLEYKKGE 251 Query: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSK 307 ++ +I + +IL+ E Y+ +C+ I + K +V++ +K I +DLA H+L + Sbjct: 252 SQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGI-----SDLAQHYLMR 306 Query: 308 LNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIR 367 NI ++ + + + +++ G + ++ E E+ +G+ + EI G + T I Sbjct: 307 ANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDEY--FTFIT 364 Query: 368 NNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSK 427 ++++RGA+ I+ E ER+L DA+ V R ++ + L+ GGGA E+ ++ L++ Sbjct: 365 ECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTE 424 Query: 428 EARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKH--ENGELNDGISVR 485 ++++M GV+ + ++ A ALEVIP TL +N G ++I+++T LR+KH EN E G++ Sbjct: 425 KSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCE-TWGVNGE 483 Query: 486 RSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 + E I +P+ V A E +LRIDDI Sbjct: 484 TGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDI 522 >4B2T-H nrPDB Length = 543 Score = 265 bits (676), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 162/517 (31%), Positives = 282/517 (54%), Gaps = 28/517 (5%) Query: 17 PQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVAR 76 PQ V +NI A + +A+A+RT+LGP+GMDK+I RG+ ISNDG TILK + ++HP A+ Sbjct: 20 PQLV--SNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAK 77 Query: 77 MLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILL 136 LV+++ +QD+E GDGTTSV +L L + + +G+HP II +F++A + +V+ + Sbjct: 78 TLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIK 137 Query: 137 EMCHKVSLSD----REQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLN 192 E+ V D R+ L + A T+LSSK++SQ +F A + VD+V+ + D + L Sbjct: 138 EIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDL----LQLK 193 Query: 193 DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAG---GPTRKEKAKIGL--IQFQISPPKPD 247 I + K GG +++++++ GV +T AG P + I L ++ ++ K + Sbjct: 194 MIGIKKVQGGALEESQLVAGVAFKKT-FSYAGFEMQPKKYHNPMIALLNVELELKAEKDN 252 Query: 248 TENNI-IVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLS 306 E + V DY+ I+ E L + +KI + V+L + I D+A + + Sbjct: 253 AEIRVHTVEDYQ---AIVDAEWNILYDKLEKIHHSGAKVVLSKLPI-----GDVATQYFA 304 Query: 307 KLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGI 366 ++ + E+++ G + + D LG + EE G + TG Sbjct: 305 DRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIGGERYNFFTGC 364 Query: 367 RNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLS 426 T ++++RG ++ETERSLHDA+ ++R +K ++AGGGA E+E+S+ L Sbjct: 365 PKAK---TCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLR 421 Query: 427 KEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRR 486 +R++ G Q + +A ALE+IP L +NAG ++ ++ +LR++H G + G+ + Sbjct: 422 DYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINT 481 Query: 487 SGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDD 523 + +E + +P +V +A+T ASE I+ +D+ Sbjct: 482 EDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDE 518 >5GW5-g nrPDB Length = 534 Score = 237 bits (605), Expect = 8e-63, Method: Compositional matrix adjust. Identities = 146/512 (28%), Positives = 281/512 (54%), Gaps = 18/512 (3%) Query: 23 ANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVS 82 +NI AA++VAD IRT LGPK M KM+ G ++++NDGH IL+++ + HP A+ ++E+S Sbjct: 23 SNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELS 82 Query: 83 AAQDSEAGDGTTSVVILTGALLG-AAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHK 141 QD E GDGTT+V+IL G +L A L+ K IHP II + + A +++++ ++ Sbjct: 83 RTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKP 142 Query: 142 VSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSV------LKISDENSKNVDLN--- 192 V + + + + S+ +K V +S + LA+D+V L + E N +++ Sbjct: 143 VDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKR 202 Query: 193 DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNI 252 +R+ K GG + D+ ++ GV+L + + E ++ L+ + K +++ NI Sbjct: 203 YVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMS-RHIENPRVVLLDCPLEYKKGESQTNI 261 Query: 253 IVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMV 312 + ++IL+ E + +C++I + +++ +K V+DLA H+L K V Sbjct: 262 EIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEK-----GVSDLAQHYLLKGGCSV 316 Query: 313 VKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNAR 372 ++ +++ + +++ G + +E E +G+ + +++ G + + + N Sbjct: 317 LRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYF--SFLDNCKEP 374 Query: 373 PTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSM 432 ++++RG + I++E +R+L DA+ V R ++ L GGGA E+ +S +L+++A+ + Sbjct: 375 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQL 434 Query: 433 EGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNT 492 EG+Q + +Q A A+E IP TL +NAG + I+++++LR+KH G GI + + Sbjct: 435 EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDM 494 Query: 493 YEEHILQPVLVSTSAITLASECVKSILRIDDI 524 I +P ++ ++ A E +LR+DDI Sbjct: 495 VSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 526 >5GW4-h nrPDB Length = 550 Score = 234 bits (597), Expect = 7e-62, Method: Compositional matrix adjust. Identities = 162/512 (31%), Positives = 275/512 (53%), Gaps = 28/512 (5%) Query: 23 ANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVS 82 +NI A +V +A++ +LGP G D +I TS + ISNDG TILK + ++HP A+ LV++S Sbjct: 28 SNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDIS 87 Query: 83 AAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKV 142 AQD+E GDGTTSV IL G L+ A+ L +GI +I ++ A +V+ + E+ + Sbjct: 88 RAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDI 147 Query: 143 SL---SDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLND--IRLV 197 + S RE L R A T++SSK++ + F + VD+VL + D N DL+D I + Sbjct: 148 TSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL-DRN----DLDDKLIGIK 202 Query: 198 KKVGGTIDDTEMIDGVVLTQTAIKSAG---GPTRKEKAKIGL--IQFQISPPKPDTENNI 252 K GG ++++ I+GV +T AG P + KI ++ ++ K + E + Sbjct: 203 KIPGGAMEESLFINGVAFKKT-FSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRV 261 Query: 253 -IVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIM 311 V DY+ I+ E + +++++ N++L + I DLA F + NI Sbjct: 262 EHVEDYQ---AIVDAEWQLIFEKLRQVEETGANIVLSKLPI-----GDLATQFFADRNIF 313 Query: 312 VVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNA 371 + +++ + + +G + + LG+ L EE+ GS+ R + Sbjct: 314 CAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQI-GSE--RYNLFQGCPQ 370 Query: 372 RPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARS 431 T ++++RG +I E ERSLHDA+ +++ ++ + ++AGGGA E+E+S+ L +++ Sbjct: 371 AKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKT 430 Query: 432 MEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTN 491 + G Q I FA ALEVIP L ENAG ++I+++ +LR H GE G+ + Sbjct: 431 IAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGD 490 Query: 492 TYEEHILQPVLVSTSAITLASECVKSILRIDD 523 + + + +P LV +A+ A+E IL +D+ Sbjct: 491 NFAKFVWEPALVKINALNSATEATNLILSVDE 522 >4V8R-AB nrPDB Length = 527 Score = 232 bits (591), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 161/526 (30%), Positives = 284/526 (53%), Gaps = 30/526 (5%) Query: 14 KEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKT-SRGEIIISNDGHTILKQMAILH 72 +E+ + R + + A +V D ++++LGPKGMDK++++ S +++NDG TILK + + + Sbjct: 12 EERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDN 71 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKG-IHPTIIADSFQSA---- 127 P A++LV +S QD E GDGTTSV +L+ LL AE+L+++ IHP I + ++ A Sbjct: 72 PAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAA 131 Query: 128 ----AKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD 183 K +VD H ++ RE L+ A T+LSSKI+SQ A LA +++L++ Sbjct: 132 LDALTKAAVD----NSHDKTMF-REDLIHIAKTTLSSKILSQDKDHFAELATNAILRLKG 186 Query: 184 ENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISP 243 + +L I+++K +GG + D+ + +G +L + P R E AKI + + Sbjct: 187 ----STNLEHIQIIKILGGKLSDSFLDEGFILAKKF--GNNQPKRIENAKILIANTTLDT 240 Query: 244 PKPDT-ENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLAL 302 K V+ ++ ++ K ER + N KI K N I R + D Sbjct: 241 DKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTF-----INRQLIYDYPE 295 Query: 303 HFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVR 362 + L I ++ + E +E L+ G + ++ + ++ +LG D++EEI ++ Sbjct: 296 QLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLK 355 Query: 363 VTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEIS 422 +G + A ++V+RGA + +DE ERSLHDAL V+ KE + GGG E+ +S Sbjct: 356 FSGCKAGEA---CTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMS 412 Query: 423 RRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGI 482 + + EA++++G ++ + FA AL +PT LA+NAG +S ++V++LRS NG G+ Sbjct: 413 KAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSGL 472 Query: 483 SVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + + + I++ + + ++ ASE + +LR+D+I +R Sbjct: 473 DLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRAR 518 >4V94-A nrPDB Length = 559 Score = 229 bits (585), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 165/543 (30%), Positives = 277/543 (51%), Gaps = 37/543 (6%) Query: 7 SNATFKNKEK--PQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTI 64 S+ F EK ++R N++A +VA+ +++SLGP G+DKM+ G+ ++NDG TI Sbjct: 10 SDTLFLGGEKISGDDIRNQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATI 69 Query: 65 LKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSF 124 L + + HP ++LVE++ QD E GDGTTSVVI+ LL A L+ IHPT I F Sbjct: 70 LSLLDVQHPAGKILVELAQQQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGF 129 Query: 125 QSAAKRSVDILLE-MCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD 183 + A + ++ + E + V +E L+ A TS+SSKI+ S F + + VD++L + Sbjct: 130 RVALREAIRFINEVLSTSVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKT 189 Query: 184 ENSKN---VDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTR--KEKAKIGLIQ 238 +NSK + + ++K G + ++ ++ G L T + S P R KI + Sbjct: 190 QNSKGEIKYPVKAVNVLKAHGKSATESLLVPGYALNCT-VASQAMPKRIAGGNVKIACLD 248 Query: 239 FQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVN 298 + + I ++D Q+++I K E +L KKI A V+L K I + Sbjct: 249 LNLQKARMAMGVQINIDDPEQLEQIRKREAGIVLERVKKIIDAGAQVVLTTKGI-----D 303 Query: 299 DLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADI------ELFTEDRLGSAD-LVE 351 DL L + IM V+ ++E++ +++ G ++ + E F LG D +V+ Sbjct: 304 DLCLKEFVEAKIMGVRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQ 363 Query: 352 EIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLI 411 SD I+ I+ + + S+++RGAN+ +DE ERSLHD+L V++ ++ ++ Sbjct: 364 AKFSDDECIL----IKGTSKHSSSSIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVV 419 Query: 412 AGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRS 471 GGG E ++ L A ++ + EFA+AL +IP TLA NA +S ++V +LRS Sbjct: 420 PGGGCVEAALNIYLDNFATTVGSREQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRS 479 Query: 472 KHENGEL------------NDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSIL 519 H ++ N G+ + R + +L+P + ++ A E +IL Sbjct: 480 YHAASQMAKPEDVKRRSYRNYGLDLIRGKIVDEIHAGVLEPTISKVKSLKSALEACVAIL 539 Query: 520 RID 522 RID Sbjct: 540 RID 542 >4B2T-B nrPDB Length = 535 Score = 219 bits (557), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 157/523 (30%), Positives = 273/523 (52%), Gaps = 30/523 (5%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTS--RGEIIISNDGHTILKQMAI 70 ++E+ + R ++ I A ++ D ++++LGPKGMDK++ +S ++++NDG TILK + + Sbjct: 17 DEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGV 76 Query: 71 LHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKR 130 +P A++LV++S QD E GDGTTSV +L LL AE L+ K IHP I ++ A K Sbjct: 77 DNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKA 136 Query: 131 SVDILLEMC--HKV-SLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSK 187 + LL H + R+ L+ A T+LSSK+++ + LAV++VL++ Sbjct: 137 ARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSG-- 194 Query: 188 NVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPD 247 +L I ++KK+GG++ D+ + +G +L + P R E AKI I+ D Sbjct: 195 --NLEAIHVIKKLGGSLADSYLDEGFLLDKKI--GVNQPKRIENAKI-----LIANTGMD 245 Query: 248 TENNIIVNDYRQMD---KILKEERAYLLNICK---KIKKAKCNVLLIQKSILRDAVNDLA 301 T+ I ++D K+ + E A + + +I K N I R + + Sbjct: 246 TDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCF-----INRQLIYNYP 300 Query: 302 LHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIV 361 +M ++ + +E L+ G + + + +LGS L+EE+ K++ Sbjct: 301 EQLFGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLI 360 Query: 362 RVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEI 421 +G+ A ++V+RGA I+DE ERSLHDALCV+ VK+ + GGG E+ + Sbjct: 361 HFSGVALGEA---CTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLM 417 Query: 422 SRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDG 481 + +++ A G +A + +A AL ++PT +A+NAG +S +V +LR+ H G+ G Sbjct: 418 AHAVTQLASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGKTTAG 477 Query: 482 ISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 + ++ + I + V + A+E + ILR+D+I Sbjct: 478 LDMKEGTIGDMSVLGITESFQVKRQVLLSAAEAAEVILRVDNI 520 >4B2T-Z nrPDB Length = 531 Score = 197 bits (501), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 152/522 (29%), Positives = 273/522 (52%), Gaps = 32/522 (6%) Query: 16 KPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVA 75 + Q NI AAR + D +RT+LGPKG KM+ + G+I ++ DG+ +L +M I HP A Sbjct: 15 RAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTA 74 Query: 76 RMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDIL 135 ++ +V+ AQD GDGTTS V++ G LL A+ +++G+HP II + F++A ++++ L Sbjct: 75 SLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFL 134 Query: 136 LEMCHKVSLS-DREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDI 194 ++ KVS DRE L+ A TSL +K+ ++ + L VDS+L I ++ + +DL + Sbjct: 135 EQV--KVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQD-EPIDLFMV 191 Query: 195 RLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIV 254 +++ + DT +I G+VL A + R E A I + K + + Sbjct: 192 EIMEMKHKSETDTSLIRGLVLDHGA-RHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFY 250 Query: 255 NDYRQMDKILKEERAYLLNICKKI---KKAKCN------VLLIQKSILRDAVNDLALHFL 305 + +K++K ER ++ + KKI KK C V++ QK I + +L L Sbjct: 251 KSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGI-----DPFSLDAL 305 Query: 306 SKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTG 365 +K I+ ++ +R +E L+ G + ++ D LG A LV E K + Sbjct: 306 AKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGEEKFTFIE- 364 Query: 366 IRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRL 425 + NN R +V+++I+G N + + + ++ D L ++ + + ++ G GA E+ ++ L Sbjct: 365 -KCNNPR-SVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEAL 422 Query: 426 SKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKH-ENGE-----LN 479 K S++G Q FA AL +IP LA+N+G + + + +++++H E+G+ LN Sbjct: 423 VKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLN 482 Query: 480 DG--ISVRRSGTTNTY--EEHILQPVLVSTSAITLASECVKS 517 G + +G + Y ++ +L V + I L E +++ Sbjct: 483 TGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRA 524 >4B2T-Q nrPDB Length = 548 Score = 192 bits (488), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 141/517 (27%), Positives = 272/517 (52%), Gaps = 20/517 (3%) Query: 18 QEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARM 77 +E NI A + +A RT+ GP GM+KM+ ++ ++ND TIL+++ + HP A+M Sbjct: 26 EEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKM 85 Query: 78 LVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLE 137 +V S Q+ E GDGT V++ GALL AE LL G+ + + + ++ A K++ +IL + Sbjct: 86 IVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEGYEIACKKAHEILPD 145 Query: 138 M--CHKVSLSDREQLVRAASTSLSSKIVSQYSS--FLAPLAVDSVLKISDENSKNVDLND 193 + C +L D +++ TS+ SK QY + FLA L + + I +S + ++++ Sbjct: 146 LVCCSAKNLRDVDEVSSLLHTSVMSK---QYGNEVFLAKLIAQACVSIF-PDSGHFNVDN 201 Query: 194 IRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNII 253 IR+ K +G + + ++ G+V + ++ G T + AKI + +T+ ++ Sbjct: 202 IRVCKILGSGVHSSSVLHGMVFKK---ETEGDVTSVKDAKIAVYSCPFDGMITETKGTVL 258 Query: 254 VNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVV 313 + ++ K E + K I NV+ + V D+ALH+ +K NIM+V Sbjct: 259 IKSAEELMNFSKGEENLMDAQVKAIADTGANVV-----VTGGRVADMALHYANKYNIMLV 313 Query: 314 KDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARP 373 + + ++ L K +G + + + +G D V + +++V + + A Sbjct: 314 RLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAIS 373 Query: 374 TVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSME 433 T +V+RG+ + ++D+ ER++ D + + L +++ L+ GGGA EIE++++++ + Sbjct: 374 T--IVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCP 431 Query: 434 GVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRS--GTTN 491 G++ + ++FA A E IP LAEN+G+ + +V+++L + H+ G N G+ + + Sbjct: 432 GLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKD 491 Query: 492 TYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 E +L L AI LA+ ++LR+D I ++ Sbjct: 492 MLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAK 528 >5GW5-z nrPDB Length = 546 Score = 191 bits (485), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 147/523 (28%), Positives = 261/523 (49%), Gaps = 29/523 (5%) Query: 22 KANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEV 81 K N+ +A + + T+LGPKG KM+ G I ++ DG +L +M I P A ++ Sbjct: 20 KVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARA 79 Query: 82 SAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEM-CH 140 +AAQD GDGTT+VV L G LL A R + +G+HP II D F+ A K S+ L E Sbjct: 80 AAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKIS 139 Query: 141 KVSLS-DREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLVKK 199 K +LS DRE L++ A +SL +K+ + + L P+ D+VL + D + N+DL+ + +++ Sbjct: 140 KTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQM 199 Query: 200 VGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQ 259 + DT I G+VL + PTR + A + ++ + K + + + Q Sbjct: 200 QHLSPKDTTFIKGLVLDHGG-RHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQ 258 Query: 260 MDKILKEERAYLLNICKKIKKAKCNVLLIQKS-----ILRDAVNDLALHFLSKLNIMVVK 314 DK+ ER ++ KKI K V + I + ++ ++L +K NI+ ++ Sbjct: 259 RDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALR 318 Query: 315 DIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPT 374 +R +E L G + +E + LG + LV + K VT N + Sbjct: 319 RAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVT---ENTDPKS 375 Query: 375 VSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISR--------RLS 426 +++I+G+ + + +T+ ++ D L + ++K++ +I G GA I +SR +L Sbjct: 376 CTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLG 435 Query: 427 KEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND-----G 481 + ++ G++A FA AL VIP TL +N+G + + V+ + + ++ + +D G Sbjct: 436 AKGKTKTGIEA-----FAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVG 490 Query: 482 ISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 + + + + E I V +AIT A+ ++L D++ Sbjct: 491 VDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDEL 533 >5GW5-q nrPDB Length = 568 Score = 189 bits (480), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 152/557 (27%), Positives = 276/557 (49%), Gaps = 38/557 (6%) Query: 1 MSAKVPSNAT---FKNKEKPQEVRKANII----AARSVADAIRTSLGPKGMDKMIKTSRG 53 MS ++P N FK II A R + TS+GP G +K+I G Sbjct: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 Query: 54 EIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNK 113 +III+ND T+L+++ I+HP ++LV + Q + GDGT V+IL G LL +E+L++ Sbjct: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 Query: 114 GIHPTIIADSFQSAAKRSVDILLEMC--HKVSLSDREQLVRAASTSLSSKIVSQYSS--F 169 G+ I + A K ++ L EM +D+ +L++ +SSK +Y S Sbjct: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSK---KYGSEDI 177 Query: 170 LAPL---AVDSVLKISDENSK--NVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAG 224 L+ L AV VL ++ + + +++ IR+VK +GG++ ++ +I G+V + Sbjct: 178 LSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVK 237 Query: 225 GPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCN 284 + +K K+ + + +T+ +++++ ++M K E + + K+I Sbjct: 238 SLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVE 297 Query: 285 VLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRL 344 + + V +LALH+L++ I+V+K + E+ L + G P+ + T + L Sbjct: 298 CI-----VAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEEL 352 Query: 345 GSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCL 404 G + V+ ++ G ++ + +R T ++++RGA +D+ ER++ D + ++ L Sbjct: 353 GLVETVKTMEIGGDRVTVFKQEQGEISR-TSTIILRGATQNNLDDIERAIDDGVAAVKGL 411 Query: 405 VKERG--LIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNS 462 +K G L+ G GA EIE+ R++K G+ ++FA A EV+P TLAE AGL+ Sbjct: 412 MKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDV 471 Query: 463 IKVVTELRSKH---ENG-----ELNDGISV---RRSGTTNTYEEHILQPVLVSTSAITLA 511 +V+ L + H E G L G+ + G + EE+I + AI +A Sbjct: 472 NEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVA 531 Query: 512 SECVKSILRIDDIAFSR 528 +E ++L ID I ++ Sbjct: 532 TEAATTVLSIDQIIMAK 548 >4V8R-AG nrPDB Length = 590 Score = 147 bits (372), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 94/334 (28%), Positives = 181/334 (54%), Gaps = 16/334 (4%) Query: 23 ANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVS 82 +NI AA++VAD IRT LGPK M KM+ G ++++NDGH IL+++ + HP A+ ++E+S Sbjct: 23 SNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELS 82 Query: 83 AAQDSEAGDGTTSVVILTGALLG-AAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHK 141 QD E GDGTT+V+IL G +L A L+ K IHP II + + A +++++ ++ Sbjct: 83 RTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKP 142 Query: 142 VSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSV------LKISDENSKNVDLN--- 192 V + + + + S+ +K V +S + LA+D+V L + E N +++ Sbjct: 143 VDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKR 202 Query: 193 DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNI 252 +R+ K GG + D+ ++ GV+L + + E ++ L+ + K +++ NI Sbjct: 203 YVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMS-RHIENPRVVLLDCPLEYKKGESQTNI 261 Query: 253 IVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMV 312 + ++IL+ E + +C++I + +++ +K V+DLA H+L K V Sbjct: 262 EIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEK-----GVSDLAQHYLLKGGCSV 316 Query: 313 VKDIEREEIEFLSKGLGCKPIADIELFTEDRLGS 346 ++ +++ + +++ G + +E E +G+ Sbjct: 317 LRRVKKSDNNRIARVTGATIVNRVEDLKESDVGT 350 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 50/149 (33%), Positives = 91/149 (61%) Query: 376 SVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGV 435 ++++RG + I++E +R+L DA+ V R ++ L GGGA E+ +S +L+++A+ +EG+ Sbjct: 434 TIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGI 493 Query: 436 QAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEE 495 Q + +Q A A+E IP TL +NAG + I+++++LR+KH G GI + + Sbjct: 494 QQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSY 553 Query: 496 HILQPVLVSTSAITLASECVKSILRIDDI 524 I +P ++ ++ A E +LR+DDI Sbjct: 554 GIWEPEVIKQQSVKTAIESACLLLRVDDI 582 >5X9V-A nrPDB Length = 521 Score = 137 bits (345), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 135/530 (25%), Positives = 251/530 (47%), Gaps = 47/530 (8%) Query: 12 KNKEKPQEVRK------ANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTIL 65 K + + QE+ + +N A +++ + SLGPKG+D M+ GE++++NDG TIL Sbjct: 2 KKENQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTIL 61 Query: 66 KQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQ 125 M HP ARM+V ++ AQ+ E GDGTT+ +L GAL+ + KG+ + + Sbjct: 62 TLMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMN 121 Query: 126 SAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDE- 184 A ++ ++ + KV ++L+ AA KI + +A + D+ + D+ Sbjct: 122 RALNHALFLIRKNAIKVGSITDDRLLAAA------KIAGRGDERVAAILRDAAAMLEDKL 175 Query: 185 NSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPP 244 L D+ L KVG DT +I GVV+ ++ + G +E ++ ++ + P Sbjct: 176 QDPGFKLADLVLA-KVGA---DTTLIPGVVINKSPLWEEGSQKLQE-VRLLVLDDGLYPE 230 Query: 245 KPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHF 304 + + E + ++ LK ++ + N+ KK+K+ ++L+ + I +D+A F Sbjct: 231 EVEEE---ALASEAGFEQYLKNQKIFQENL-KKLKELGVKLILLTRGI-----SDIAEEF 281 Query: 305 LSKLNIMVVKDIEREEIEFLSKGLGC---------KPIADIELFTEDRLGSADLVEEIDS 355 + IMV+ I ++E++ + + G KP+ ++ + LG A DS Sbjct: 282 CYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEEL----QKMLGYARTC-FYDS 336 Query: 356 DGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGG 415 + T I + T +V+I A + ++DE ER DA + G++ GGG Sbjct: 337 R----LDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRS-GVLPGGG 391 Query: 416 APEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKH-E 474 A + +SR + + G++++ F+ AL+V +AENAG N ++ + +L + + Sbjct: 392 AFFLYLSREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQ 451 Query: 475 NGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 G+ + ++ P V A+ ASE S+L+I+ I Sbjct: 452 KNNYALGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTI 501 >1E0R-B nrPDB Length = 159 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 43/159 (27%), Positives = 84/159 (52%), Gaps = 6/159 (3%) Query: 210 IDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERA 269 ++G+++ + + G P + AKI L+ + KP+ + N+ + D + K L +E Sbjct: 1 MNGIIVDKEKV-HPGMPDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEEN 59 Query: 270 YLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLG 329 L + KIK NV++ QK I +D+A H+LS+ I V+ +++ +++ L+K G Sbjct: 60 MLREMVDKIKSVGANVVITQKGI-----DDMAQHYLSRAGIYAVRRVKKSDMDKLAKATG 114 Query: 330 CKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRN 368 ++ I+ + LG+A+ VE++ + VTG +N Sbjct: 115 ASIVSTIDEISSSDLGTAERVEQVKVGEDYMTFVTGSKN 153 >1ASS-A nrPDB Length = 159 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/157 (29%), Positives = 82/157 (52%), Gaps = 6/157 (3%) Query: 212 GVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYL 271 G+V+ + + S P + AKI LI + K + E + ++D ++ L +E Sbjct: 3 GIVIDKEKVHSKM-PDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTF 61 Query: 272 LNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCK 331 + +KIKK+ NV+L QK I +D+A H+L+K I V+ +++ ++E L+K G K Sbjct: 62 KQMVEKIKKSGANVVLCQKGI-----DDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAK 116 Query: 332 PIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRN 368 + D++ T LG A+ VEE ++ V G +N Sbjct: 117 IVTDLDDLTPSVLGEAETVEERKIGDDRMTFVMGCKN 153 >1IOK-A nrPDB Length = 545 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 122/551 (22%), Positives = 227/551 (41%), Gaps = 133/551 (24%) Query: 31 VADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV----ARMLVEVSAAQD 86 +ADA++ +LGPKG + +I S G I+ DG ++ K++ + A+M+ EV++ + Sbjct: 23 LADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELSDKFENMGAQMVREVASRTN 82 Query: 87 SEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSD 146 EAGDGTT+ +L A++ + + G++P + A + V+ + V +D Sbjct: 83 DEAGDGTTTATVLAQAIVREGLKAVAAGMNPMDLKRGIDVATAKVVEAIKSAARPV--ND 140 Query: 147 REQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLVKKVGGTIDD 206 ++ + + S + + SF+ +++ ++ +E V+ N G + Sbjct: 141 SSEVAQVGTISANGE------SFIGQQIAEAMQRVGNEGVITVEENK--------GMETE 186 Query: 207 TEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKE 266 E+++G +QF P N DK++ E Sbjct: 187 VEVVEG------------------------MQFDRGYLSPYFVTN--------ADKMIAE 214 Query: 267 -ERAYLLNICKKIK-------------KAKCNVLLIQKSILRDAVNDLALHFL-SKLNIM 311 E AY+L KK+ +++ +L++ + + +A+ L ++ L L I Sbjct: 215 LEDAYILLHEKKLSSLQPMVPLLESVIQSQKPLLIVAEDVEGEALATLVVNKLRGGLKIA 274 Query: 312 VVK-----DIER---EEIEFLSKG------LGCKPIADIELFTEDRLGSADLVEEIDSDG 357 VK D + ++I L+ G LG K +E T D LG A V I+ D Sbjct: 275 AVKAPGFGDRRKAMLQDIAILTGGQVISEDLGMK----LENVTIDMLGRAKKV-SINKDN 329 Query: 358 SKIV-----------RVTGIRNNNARPT------------------VSVV-IRGANNMII 387 + IV RV+ IR T V+V+ + G + + Sbjct: 330 TTIVDGAGEKAEIEARVSQIRQQIEETTSDYDREKLQERVAKLAGGVAVIRVGGMTEIEV 389 Query: 388 DETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFAS-- 445 E + + DAL R V+E G++ GGG L + A+ +EG+ + A Sbjct: 390 KERKDRVDDALNATRAAVQE-GIVVGGGVA-------LVQGAKVLEGLSGANSDQDAGIA 441 Query: 446 ----ALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPV 501 ALE +AENAG++ V ++R E+ + G + + + ++ ++ P Sbjct: 442 IIRRALEAPMRQIAENAGVDGAVVAGKVR---ESSDKAFGFNAQTEEYGDMFKFGVIDPA 498 Query: 502 LVSTSAITLAS 512 V +A+ A+ Sbjct: 499 KVVRTALEDAA 509 >4AAR-A nrPDB Length = 548 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 42/164 (25%), Positives = 84/164 (51%), Gaps = 14/164 (8%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 M+AK + F N + + +R N++A DA++ +LGPKG + ++ S G I+ D Sbjct: 1 MAAK---DVKFGNDARVKMLRGVNVLA-----DAVKVTLGPKGRNVVLDKSFGAPTITKD 52 Query: 61 GHTILKQMAILHPV----ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIH 116 G ++ +++ + A+M+ EV++ + AGDGTT+ +L A++ + + G++ Sbjct: 53 GVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMN 112 Query: 117 PTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSS 160 P + A +V+ L + V SD + + + + S +S Sbjct: 113 PMDLKRGIDKAVTAAVEELKALS--VPCSDSKAIAQVGTISANS 154 >4V4O-A nrPDB Length = 543 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 33/132 (25%), Positives = 73/132 (55%), Gaps = 6/132 (4%) Query: 30 SVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV----ARMLVEVSAAQ 85 +VA+A++ +LGP+G + +++ G I+ DG T+ K++ + + A++L EV++ Sbjct: 21 AVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENIGAQLLKEVASKT 80 Query: 86 DSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLS 145 + AGDGTT+ +L A++ + + G +P + + A + +V+ + + + + Sbjct: 81 NDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEAAVEKIKALA--IPVE 138 Query: 146 DREQLVRAASTS 157 DR+ + A+ S Sbjct: 139 DRKAIEEVATIS 150 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 5/149 (3%) Query: 378 VIR--GANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGV 435 VIR A + E + DAL R V+E G++ GGG + + + + +EG Sbjct: 376 VIRVGAATETELKEKKHRFEDALNATRAAVEE-GIVPGGGVTLLRAISAVEELIKKLEGD 434 Query: 436 QAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEE 495 +A + ALE +AENAG +V ++ ++ +N G + + E Sbjct: 435 EATGAKIVRRALEEPARQIAENAGYEGSVIVQQILAETKNPRY--GFNAATGEFVDMVEA 492 Query: 496 HILQPVLVSTSAITLASECVKSILRIDDI 524 I+ P V+ SA+ A+ IL + + Sbjct: 493 GIVDPAKVTRSALQNAASIGALILTTEAV 521 >5DA8-A nrPDB Length = 545 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 33/117 (28%), Positives = 58/117 (49%), Gaps = 4/117 (3%) Query: 31 VADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV----ARMLVEVSAAQD 86 +A+A++ +LGP G + +I G + DG T+ K++ ++ PV A+M+ EV++ Sbjct: 23 LANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVASKTS 82 Query: 87 SEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVS 143 AGDGTT+ +L A+ + + G P + A K V L + +S Sbjct: 83 DVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAELRNISRSIS 139 Score = 36.6 bits (83), Expect = 0.031, Method: Compositional matrix adjust. Identities = 45/154 (29%), Positives = 71/154 (46%), Gaps = 7/154 (4%) Query: 375 VSVVIRGANNMI-IDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSME 433 V+V+ GA+ + + E + + DAL R V+E G++ GGG I ++ L+K E Sbjct: 376 VAVLKIGASTEVEMKEKKARVEDALHATRAAVQE-GIVVGGGVALIRAAKGLAKAVADNE 434 Query: 434 GVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTY 493 + I + ALE + N G VV E K +N E + G + R N Sbjct: 435 DQKTGI-EIIRRALEEPLRQIVANTGTTDGAVVLE---KVKNAEGDYGFNARTEQYENLI 490 Query: 494 EEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 E ++ P V+ SA+ A+ V SIL + A + Sbjct: 491 EAGVVDPTKVTRSALENAA-SVASILLTTEAAIT 523 >4PJ1-A nrPDB Length = 558 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 27/91 (29%), Positives = 51/91 (56%), Gaps = 4/91 (4%) Query: 31 VADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV----ARMLVEVSAAQD 86 +ADA+ ++GPKG +I+ S G ++ DG T+ K + + A+++ +V+ + Sbjct: 49 LADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTN 108 Query: 87 SEAGDGTTSVVILTGALLGAAERLLNKGIHP 117 EAGDGTT+ +L ++ ++KG +P Sbjct: 109 EEAGDGTTTATVLARSIAKEGFEKISKGANP 139 >1GN1-A nrPDB Length = 178 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 33/151 (21%), Positives = 76/151 (50%), Gaps = 7/151 (4%) Query: 233 KIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSI 292 +I L+ + K +++ +I + +IL+ E Y+ +C+ I + K +V++ +K I Sbjct: 29 RIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIHQLCEDIIQLKPDVVITEKGI 88 Query: 293 LRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEE 352 +DLA H+L + N+ ++ + + + +++ G + ++ E ED +G+ + E Sbjct: 89 -----SDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLE 143 Query: 353 IDSDGSKIVRVTGIRNNNARPTVSVVIRGAN 383 I G + T I + ++++RGA+ Sbjct: 144 IKKIGDEY--FTFITDCKDPKACTILLRGAS 172 >1SJP-A nrPDB Length = 504 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 6/109 (5%) Query: 53 GEIIISNDGHTILKQMAILHPV----ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAE 108 G I+NDG +I K++ + P A ++ EV+ D AGDGTT+ +L AL+ Sbjct: 2 GAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGL 61 Query: 109 RLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTS 157 R + G +P + + A ++ + LL+ +V +EQ+ A+ S Sbjct: 62 RNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVET--KEQIAATAAIS 108 >5CDI-A nrPDB Length = 552 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 61/116 (52%), Gaps = 4/116 (3%) Query: 31 VADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV----ARMLVEVSAAQD 86 +A + ++GPKG + ++++ G I NDG TI +++ + PV A ++ + +A + Sbjct: 24 LATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPVENIGATLVRQAAARTN 83 Query: 87 SEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKV 142 AGDGTT+ +L+ A + ++++ G +P + + + V L +M V Sbjct: 84 DTAGDGTTTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTVQELVKELRKMSSVV 139 Score = 28.9 bits (63), Expect = 5.8, Method: Compositional matrix adjust. Identities = 33/137 (24%), Positives = 56/137 (40%), Gaps = 4/137 (2%) Query: 387 IDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASA 446 + E + + DAL R V+E G++ GGG + +S ++ R M + + + Sbjct: 390 LKEKKLRVEDALNATRAAVEE-GVVPGGGCTLLRLSEKVDVIKRRMTDPEQQMGADIIKR 448 Query: 447 LEVIPTTL-AENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVST 505 P L A+NAG+N V+ E+ + G + N E I+ P V Sbjct: 449 ALCYPIKLIAQNAGVNGSVVMNEVMKNLDRPHY--GYNAATDSFENLMETGIIDPSKVVR 506 Query: 506 SAITLASECVKSILRID 522 ++ A K+ L D Sbjct: 507 CSMENAVSVAKTFLLAD 523 >2B7M-A nrPDB Length = 566 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 3/52 (5%) Query: 54 EIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLG 105 +I++ ILK MA L P A+ E+S A+++ G++ + T ALLG Sbjct: 143 DILVGERSKLILKCMAFLEPFAK---EISTAKNAPYEKGSSGMNSYTEALLG 191 >4V4N-AO nrPDB Length = 197 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 35/81 (43%), Gaps = 7/81 (8%) Query: 92 GTTSVVILTGALLGAA-------ERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSL 144 G T L G L+G E +L+ G+HP + S + K +VD L + H + Sbjct: 78 GNTPSAYLLGLLIGYKAKQAGIEEAILDIGLHPPVRGSSVFAVLKGAVDAGLNVPHSPEI 137 Query: 145 SDREQLVRAASTSLSSKIVSQ 165 E +R + +K++ + Sbjct: 138 FPDEYRIRGEHIAEYAKMLKE 158 >4PHT-A nrPDB Length = 500 Score = 29.3 bits (64), Expect = 4.8, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 1/51 (1%) Query: 100 TGALLGAAERLLNKGIHPTIIADSFQSA-AKRSVDILLEMCHKVSLSDREQ 149 T +GA RL + GI P +I+ S A+R V L + C + +D+EQ Sbjct: 357 TNTAVGAITRLRDMGIEPFLISSSLLGVLAQRLVRTLCQDCKEPYEADKEQ 407 >4KSS-A nrPDB Length = 581 Score = 28.5 bits (62), Expect = 6.6, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 26/51 (50%), Gaps = 1/51 (1%) Query: 100 TGALLGAAERLLNKGIHPTIIADSFQSA-AKRSVDILLEMCHKVSLSDREQ 149 T +GA RL + GI P +I+ S A+R V L C + +D+EQ Sbjct: 262 TNTAVGAVTRLRDMGIEPFLISSSLLGVLAQRLVRTLCPDCKEPYEADKEQ 312 >1P9R-A nrPDB Length = 418 Score = 28.5 bits (62), Expect = 8.2, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 26/51 (50%), Gaps = 1/51 (1%) Query: 100 TGALLGAAERLLNKGIHPTIIADSFQSA-AKRSVDILLEMCHKVSLSDREQ 149 T +GA RL + GI P +I+ S A+R V L C + +D+EQ Sbjct: 270 TNTAVGAVTRLRDMGIEPFLISSSLLGVLAQRLVRTLCPDCKEPYEADKEQ 320 >5JY6-A nrPDB Length = 356 Score = 28.1 bits (61), Expect = 8.7, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 26/54 (48%), Gaps = 4/54 (7%) Query: 351 EEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCL 404 + I +G+K V +T N+ V V+ N+ I+D TE + A C CL Sbjct: 128 QHIHENGAKKVVITAPGGND----VKTVVFNTNHDILDGTETVISGASCTTNCL 177 >3LL9-A nrPDB Length = 269 Score = 28.1 bits (61), Expect = 9.7, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 4/69 (5%) Query: 55 IIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLL--- 111 +I+ D + + HP AR+L + + D E+ DGT + + TG ++G LL Sbjct: 176 VILGTDVDGVYTRNPKKHPDARLLDVIGSLDDLESLDGTLNTDV-TGGMVGKIRELLLLA 234 Query: 112 NKGIHPTII 120 KG+ II Sbjct: 235 EKGVESEII 243 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5GW4-d nrPDB 600 e-172 4XCG-B nrPDB 573 e-164 1Q3S-A nrPDB 571 e-163 3J1C-A nrPDB 567 e-162 3J1E-A nrPDB 567 e-162 4B2T-D nrPDB 565 e-161 1A6E-A nrPDB 562 e-160 1A6D-B nrPDB 560 e-160 4XCI-A nrPDB 553 e-158 3RUW-A nrPDB 544 e-155 4B2T-G nrPDB 543 e-155 5UYZ-A nrPDB 541 e-154 4V8R-AE nrPDB 539 e-153 4B2T-H nrPDB 531 e-151 5GW5-g nrPDB 531 e-151 3AQ1-B nrPDB 525 e-149 4B2T-A nrPDB 520 e-148 5GW4-h nrPDB 516 e-147 3IYF-A nrPDB 514 e-146 4V8R-AG nrPDB 511 e-145 4V94-A nrPDB 491 e-139 4B2T-Q nrPDB 484 e-137 4B2T-B nrPDB 484 e-137 4V8R-AB nrPDB 481 e-136 4B2T-Z nrPDB 480 e-136 5GW5-q nrPDB 471 e-133 5GW5-z nrPDB 469 e-132 5X9V-A nrPDB 388 e-108 1IOK-A nrPDB 253 1e-67 4V4O-A nrPDB 231 7e-61 4AAR-A nrPDB 205 4e-53 5DA8-A nrPDB 192 3e-49 4PJ1-A nrPDB 190 1e-48 1SJP-A nrPDB 173 2e-43 1GN1-A nrPDB 169 2e-42 1E0R-B nrPDB 166 3e-41 1ASS-A nrPDB 162 3e-40 Sequences not found previously or not previously below threshold: 5CDI-A nrPDB 154 9e-38 3E0V-A nrPDB 42 8e-04 3LXD-A nrPDB 40 0.003 3BWN-A nrPDB 32 0.97 5T6O-A nrPDB 31 1.4 1QH8-B nrPDB 30 2.2 4OTL-A nrPDB 30 2.4 6ESQ-A nrPDB 30 2.8 5NYW-A nrPDB 30 3.3 3TZ6-A nrPDB 30 3.7 1XG3-A nrPDB 30 3.7 5CB0-A nrPDB 29 4.0 2IOU-G nrPDB 29 4.2 5Z9A-A nrPDB 29 4.7 2VHI-A nrPDB 29 5.4 4PLW-A nrPDB 28 8.5 1Q1R-A nrPDB 28 9.4 >5GW4-d nrPDB Length = 528 Score = 600 bits (1546), Expect = e-172, Method: Composition-based stats. Identities = 528/528 (100%), Positives = 528/528 (100%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND Sbjct: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 Query: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTII 120 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTII Sbjct: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTII 120 Query: 121 ADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLK 180 ADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLK Sbjct: 121 ADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLK 180 Query: 181 ISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQ 240 ISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQ Sbjct: 181 ISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQ 240 Query: 241 ISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDL 300 ISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDL Sbjct: 241 ISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDL 300 Query: 301 ALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKI 360 ALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKI Sbjct: 301 ALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKI 360 Query: 361 VRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIE 420 VRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIE Sbjct: 361 VRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIE 420 Query: 421 ISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND 480 ISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND Sbjct: 421 ISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND 480 Query: 481 GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR Sbjct: 481 GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 >4XCG-B nrPDB Length = 557 Score = 573 bits (1477), Expect = e-164, Method: Composition-based stats. Identities = 189/518 (36%), Positives = 313/518 (60%), Gaps = 12/518 (2%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILH 72 ++ +E +ANI A +++ +A++++ GP+GMDKM+ S G+I I+NDG TIL +M + H Sbjct: 26 SRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQH 85 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSV 132 P ++LV+++ QD E DGT + VIL G L AE LL K IHPTII ++ A + ++ Sbjct: 86 PTGKLLVQIAKGQDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVSGYKKAEEIAL 145 Query: 133 DILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD--ENSKNVD 190 + E+ V+++D + L + A TSL SK V+ +LA L V +V ++++ + VD Sbjct: 146 KTIQEIAQPVTINDTDVLRKVALTSLGSKAVAGAREYLADLVVKAVAQVAELRGDKWYVD 205 Query: 191 LNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTEN 250 L+++++VKK GG+++DT+++ G+V+ + + G P R E AKI L+ + KP+ + Sbjct: 206 LDNVQIVKKHGGSVNDTQLVYGIVVDKEVV-HPGMPKRIENAKIALLDASLEVEKPELDA 264 Query: 251 NIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNI 310 I +ND QM K L+EE L KI NV++ QK I +++A H+L+K I Sbjct: 265 EIRINDPTQMHKFLEEEENILKEKVDKIAATGANVVICQKGI-----DEVAQHYLAKKGI 319 Query: 311 MVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNN 370 + V+ ++ ++E L++ G + I++I+ T LG A LVEE K+V V G +N Sbjct: 320 LAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVEERKVGEDKMVFVEGAKNPK 379 Query: 371 ARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEAR 430 +VS++IRG ++DETER+L DAL + ++++ +AGGGA EIEI++RL K A Sbjct: 380 ---SVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAVEIEIAKRLRKYAP 436 Query: 431 SMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENG-ELNDGISVRRSGT 489 + G + + +A+A+E + LAENAGL+ I + +LRS HEN G+++ Sbjct: 437 QVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLHENETNKWYGLNLFTGNP 496 Query: 490 TNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 + ++ +++P LV +A+ A+E V +LRIDDI + Sbjct: 497 EDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAA 534 >1Q3S-A nrPDB Length = 548 Score = 571 bits (1472), Expect = e-163, Method: Composition-based stats. Identities = 192/518 (37%), Positives = 324/518 (62%), Gaps = 11/518 (2%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILH 72 + ++ ++ NI+AAR +A+ +RT+LGPKGMDKM+ S G+I+++ND TIL ++ + H Sbjct: 17 QRYVGRDAQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDCATILDKIDLQH 76 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSV 132 P A+M+VEV+ QD EAGDGTT+ V++ G LL AE LL++ IHP+II + AA+++ Sbjct: 77 PAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSIIIKGYALAAEKAQ 136 Query: 133 DILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDE--NSKNVD 190 +IL E+ +V D E L++ A+TS++ K + LA LAV++V +++++ VD Sbjct: 137 EILDEIAIRVDPDDEETLLKIAATSITGKNAESHKELLAKLAVEAVKQVAEKKDGKYVVD 196 Query: 191 LNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTEN 250 L++I+ KK G ++++E++ GVV+ + + P R E AKI LI + K +T+ Sbjct: 197 LDNIKFEKKAGEGVEESELVRGVVIDKEVV-HPRMPKRVENAKIALINEALEVKKTETDA 255 Query: 251 NIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNI 310 I + Q+ L++E L ++ I + NV+ +QK I +DLA H+L+K I Sbjct: 256 KINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGI-----DDLAQHYLAKYGI 310 Query: 311 MVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNN 370 M V+ +++ ++E L+K G K + +++ T + LG A++VEE G ++ V G +N Sbjct: 311 MAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAGENMIFVEGCKNPK 370 Query: 371 ARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEAR 430 A V+++IRG +IDE ER+L DA+ V++ ++++ ++ GGAPEIE++ RL + A+ Sbjct: 371 A---VTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIELAIRLDEYAK 427 Query: 431 SMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTT 490 + G +A + FA AL++IP TLAENAGL++++++ ++ S+H+N L GI V Sbjct: 428 QVGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISEHKNRGLGIGIDVFEGKPA 487 Query: 491 NTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + E+ I++P+ V AI ASE ILRIDD+ ++ Sbjct: 488 DMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDVIAAK 525 >3J1C-A nrPDB Length = 563 Score = 567 bits (1462), Expect = e-162, Method: Composition-based stats. Identities = 207/542 (38%), Positives = 331/542 (61%), Gaps = 25/542 (4%) Query: 1 MSAKVPSNATFK---NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIII 57 MS+ VP FK ++ ++ K NI+AAR++A+ +R+SLGPKG+DKM+ S G++ I Sbjct: 1 MSSGVPV-LLFKEGTSRNSGRDALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTI 59 Query: 58 SNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHP 117 +NDG TI+K+M I HP A++LVE + AQDSE GDGTTS V+L G L AE L+++ IHP Sbjct: 60 TNDGATIVKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHP 119 Query: 118 TIIADSFQSAAKRSVDILLEMCHKVSLSD------REQLVRAASTSLSSKIVSQYSSF-- 169 TII + F+ A +S+++L ++ KV +SD R+ L + T++SSK +++ Sbjct: 120 TIIIEGFKKAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNK 179 Query: 170 LAPLAVDSVLKISDE---NSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGP 226 + + +D+V +++ NV L+ I++ KK GGTI+D+++I G+VL + + AG P Sbjct: 180 IMDIVIDAVTTVAEPLPDGGYNVSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVV-HAGMP 238 Query: 227 TRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVL 286 R EKAKI ++ + KP+ I + Q+ L EE YL ++ K+ NV+ Sbjct: 239 RRVEKAKIAVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGANVV 298 Query: 287 LIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGS 346 + QK I +D+A HFL+K I+ V+ ++R +IE L K LG + I+ I+ T + LG Sbjct: 299 ICQKGI-----DDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGY 353 Query: 347 ADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVK 406 A+LVEE K+V + G +N A V++++RG+N+M +DE ERS++DAL +R ++ Sbjct: 354 AELVEERKVGNDKMVFIEGAKNPKA---VNILLRGSNDMALDEAERSINDALYSLRNILM 410 Query: 407 ERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVV 466 E ++ GGGA E+E+S RL + ARS+ G + + +A ALE IP LAE AGL I + Sbjct: 411 EPYIVPGGGAIELELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISAL 470 Query: 467 TELRSKHENGELNDGISVRRSGTT-NTYEEHILQPVLVSTSAITLASECVKSILRIDDIA 525 +LR++H G N G+ V + Y ++++P+ V+ + A+E SI++IDD+ Sbjct: 471 MDLRARHAKGLTNCGVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDLI 530 Query: 526 FS 527 + Sbjct: 531 AA 532 >3J1E-A nrPDB Length = 553 Score = 567 bits (1461), Expect = e-162, Method: Composition-based stats. Identities = 186/518 (35%), Positives = 314/518 (60%), Gaps = 12/518 (2%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILH 72 ++ +E +ANI A ++V +A++++ GP+GMDKM+ S G+I I+NDG TIL +M + H Sbjct: 24 SRTYGKEAVRANIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQH 83 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSV 132 P A++LV+++ QD E DGT + VI +G L+ AE LL K +HPTII ++ A + ++ Sbjct: 84 PAAKLLVQIAKGQDEETADGTKTAVIFSGELVKKAEDLLYKDVHPTIIISGYKKAEEVAL 143 Query: 133 DILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD--ENSKNVD 190 + E+ VS++D + L + A TSLSSK V+ ++A + V +V ++++ + VD Sbjct: 144 QTIQELAQTVSINDTDLLRKIAMTSLSSKAVAGAREYIADIVVKAVTQVAELRGDKWYVD 203 Query: 191 LNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTEN 250 L++I++VKK GG+I+DT+++ G+V+ + + G P R E AKI LI + KP+ + Sbjct: 204 LDNIQIVKKAGGSINDTQLVYGIVVDKEVV-HPGMPKRLENAKIALIDASLEVEKPELDA 262 Query: 251 NIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNI 310 I +ND QM K L EE + KI NV++ QK I +++A +L+K + Sbjct: 263 EIRINDPTQMQKFLDEEENLIKEKVDKILATGANVIICQKGI-----DEVAQSYLAKKGV 317 Query: 311 MVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNN 370 + V+ ++ ++E L++ G + +++I+ +E LG A L+EE K+V V G +N Sbjct: 318 LAVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGYASLIEERKVGEDKMVFVEGAKNPK 377 Query: 371 ARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEAR 430 ++S++IRG ++DETER+L DAL + ++K+ IAGGGA EIEI+++L K A Sbjct: 378 ---SISILIRGGLERLVDETERALRDALGTVADVIKDGRAIAGGGAVEIEIAKKLRKYAP 434 Query: 431 SMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHEN-GELNDGISVRRSGT 489 + G + + +A+ALE + + L ENAG + I ++ +LRS HEN GI + Sbjct: 435 QVGGKEQLAVEAYANALESLVSILIENAGFDPIDLLMKLRSTHENENNKWYGIDLYAGQP 494 Query: 490 TNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 + +++ +++P LV +AI A+E +LRIDD+ + Sbjct: 495 VDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVSA 532 >4B2T-D nrPDB Length = 542 Score = 565 bits (1456), Expect = e-161, Method: Composition-based stats. Identities = 310/522 (59%), Positives = 424/522 (81%), Gaps = 6/522 (1%) Query: 9 ATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQM 68 + +++++KP ++R +NI AA++VADAIRTSLGPKGMDKMI+ +G++ I+NDG TILKQM Sbjct: 25 SAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQM 84 Query: 69 AILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAA 128 +LHP ARMLVE+S AQD EAGDGTTSVVI+ G+LL + +LL KGIHPTII++SFQ A Sbjct: 85 QVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKAL 144 Query: 129 KRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDEN-SK 187 ++ ++IL +M V LSDRE L+ +A+TSL+SK+VSQYSS L+P++VD+V+K+ D + Sbjct: 145 EKGIEILTDMSRPVELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATAT 204 Query: 188 NVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPD 247 +VDL DI++VKK+GGTIDD E+++G+VLTQ S G TR EKAKIGLIQF +S PK D Sbjct: 205 SVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANS--GITRVEKAKIGLIQFCLSAPKTD 262 Query: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSK 307 +N I+V+DY QMD++L+EERAY+LN+ K+IKK CNVLLIQKSILRDA++DLALHFL+K Sbjct: 263 MDNQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNK 322 Query: 308 LNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGS-KIVRVTGI 366 + IMVVKDIERE+IEF+ K +G KP+A ++ FT D LGSA+L EE+ +GS K++++TG Sbjct: 323 MKIMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSGKLIKITGC 382 Query: 367 RNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLS 426 + TV++V+RG+N ++I+E ERS+HDALCVIRCLVK+R LIAGGGAPEIE++ RL+ Sbjct: 383 ASPG--KTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLT 440 Query: 427 KEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRR 486 + +R++ G++++ + FA A+EVIP+TLAENAGLN I VTELR++H GE GI+VR+ Sbjct: 441 EYSRTLSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRK 500 Query: 487 SGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 G +N EE ++QP+LVS SA+TLA+E V+SIL+IDD+ +R Sbjct: 501 GGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVNTR 542 >1A6E-A nrPDB Length = 545 Score = 562 bits (1449), Expect = e-160, Method: Composition-based stats. Identities = 195/518 (37%), Positives = 315/518 (60%), Gaps = 13/518 (2%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILH 72 +E+ + ++ NI AA+++ADA+RT+LGPKGMDKM+ S G+IIISNDG TILK+M + H Sbjct: 16 QREQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISNDGATILKEMDVEH 75 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSV 132 P A+M+VEVS AQD+ GDGTT+ V+L+G LL AE LL++G+HPT+I++ ++ A + Sbjct: 76 PTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVISNGYRLAVNEAR 135 Query: 133 DILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD--ENSKNVD 190 I+ E+ K + D L + A T+LS K + FLA L V +V +++ + VD Sbjct: 136 KIIDEIAEKST--DDATLRKIALTALSGKNTGLSNDFLADLVVKAVNAVAEVRDGKTIVD 193 Query: 191 LNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTEN 250 +I++ KK GG+++DT+ I G+V+ + + S P + AKI LI + K + E Sbjct: 194 TANIKVDKKNGGSVNDTQFISGIVIDKEKVHSK-MPDVVKNAKIALIDSALEIKKTEIEA 252 Query: 251 NIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNI 310 + ++D ++ L +E + +KIKK+ NV+L QK I +D+A H+L+K I Sbjct: 253 KVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVVLCQKGI-----DDVAQHYLAKEGI 307 Query: 311 MVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNN 370 V+ +++ ++E L+K G K + D++ T LG A+ VEE ++ V G +N Sbjct: 308 YAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVEERKIGDDRMTFVMGCKNPK 367 Query: 371 ARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEAR 430 A VS++IRG + ++ E ER+L+DA+ V+ ++ + GGGA E E++ RL+K A Sbjct: 368 A---VSILIRGGTDHVVSEVERALNDAIRVVAITKEDGKFLWGGGAVEAELAMRLAKYAN 424 Query: 431 SMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTT 490 S+ G + + FA ALE+IP TLAENAG++ I + +L++ E G ++ G+ + +G Sbjct: 425 SVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADDEKGRISVGVDLDNNGVG 484 Query: 491 NTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + + ++ P+ V T A+ A E ILRIDD+ S+ Sbjct: 485 DMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASK 522 >1A6D-B nrPDB Length = 543 Score = 560 bits (1444), Expect = e-160, Method: Composition-based stats. Identities = 184/517 (35%), Positives = 313/517 (60%), Gaps = 11/517 (2%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILH 72 +E ++ K NI AA ++++++R+SLGP+GMDKM+ S G+I+I+NDG TILK+M + H Sbjct: 15 KRESGKDAMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDGVTILKEMDVEH 74 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSV 132 P A+M+VEVS QDS GDGTT+ VI+ G LL A+ L+N+ +HPT+I++ ++ A++ + Sbjct: 75 PAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTVISEGYRMASEEAK 134 Query: 133 DILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD--ENSKNVD 190 ++ E+ K+ ++ L++ A TSL+SK S LA ++ ++V +++ + VD Sbjct: 135 RVIDEISTKIGADEKALLLKMAQTSLNSKSASVAKDKLAEISYEAVKSVAELRDGKYYVD 194 Query: 191 LNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTEN 250 ++I++VKK GG IDDT++I+G+++ + + G P + AKI L+ + KP+ + Sbjct: 195 FDNIQVVKKQGGAIDDTQLINGIIVDKEKV-HPGMPDVVKDAKIALLDAPLEIKKPEFDT 253 Query: 251 NIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNI 310 N+ + D + K L +E L + KIK NV++ QK I +D+A H+LS+ I Sbjct: 254 NLRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGI-----DDMAQHYLSRAGI 308 Query: 311 MVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNN 370 V+ +++ +++ L+K G ++ I+ + LG+A+ VE++ + VTG +N Sbjct: 309 YAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVGEDYMTFVTGCKNPK 368 Query: 371 ARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEAR 430 A VS+++RG ++DE ERS+ D+L V+ +++ AGGGA EI+ RL A+ Sbjct: 369 A---VSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAAEIAFRLRSYAQ 425 Query: 431 SMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTT 490 + G Q ++FA A+E IP LAENAGL+ I ++ +LR++H G GI+V Sbjct: 426 KIGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEHAKGNKTYGINVFTGEIE 485 Query: 491 NTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 + + +++P+ V AI A+E ILRIDD+ + Sbjct: 486 DMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVIAT 522 >4XCI-A nrPDB Length = 559 Score = 553 bits (1425), Expect = e-158, Method: Composition-based stats. Identities = 195/539 (36%), Positives = 329/539 (61%), Gaps = 21/539 (3%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 M+A V ++ ++ + NI+AA+++A+ +R+SLGPKG+DKM+ S G++ I+ND Sbjct: 1 MAAPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITND 60 Query: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTII 120 G TI+K M I HP A++LVE + AQD+E GDGTTS V+L GALL AE LL++ IHPTII Sbjct: 61 GATIVKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTII 120 Query: 121 ADSFQSAAKRSVDILLEMCHKVSLSD------REQLVRAASTSLSSKIVSQYSSF--LAP 172 + ++ A +++++L ++ ++ + D R+ L + A T+L+SK +++ + + Sbjct: 121 IEGYKKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIID 180 Query: 173 LAVDSVLKISDE---NSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRK 229 + +D+++ +++ NV L+ I++ KK GG+I+D+ ++ G+VL + + G P R Sbjct: 181 MVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVV-HPGMPRRV 239 Query: 230 EKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQ 289 KAKI ++ + KP+ I + Q+ L EE YL ++ K+ NV++ Q Sbjct: 240 TKAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQ 299 Query: 290 KSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADL 349 K I +D+A HFL+K I+ V+ ++R +IE L K LG + I+ I+ T + LG A+L Sbjct: 300 KGI-----DDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAEL 354 Query: 350 VEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERG 409 VEE K+V + G +N A V++++RG+N+M +DE ERS++DAL +R ++ E Sbjct: 355 VEERRVGNDKMVFIEGAKNLKA---VNILLRGSNDMALDEAERSINDALHALRNILLEPV 411 Query: 410 LIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTEL 469 ++ GGGA E+E++ +L + ARS+ G + + FA ALE IP LAE AGL +I + +L Sbjct: 412 ILPGGGAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDL 471 Query: 470 RSKHENGELNDGISVRRSGTT-NTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 R++H G N G+ V + Y +I++P+ V + + A+E +IL+IDD+ + Sbjct: 472 RARHAKGLSNTGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAA 530 >3RUW-A nrPDB Length = 543 Score = 544 bits (1401), Expect = e-155, Method: Composition-based stats. Identities = 184/529 (34%), Positives = 320/529 (60%), Gaps = 11/529 (2%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 MS + + ++ ++ NI+A R +A+ +R++LGPKGMDKM+ G+++++ND Sbjct: 1 MSQQPGVLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTND 60 Query: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTII 120 G TIL++M++ HP A+ML+EV+ Q+ E GDGTT+ V++ G LL AE LL++ +HPTI+ Sbjct: 61 GVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIV 120 Query: 121 ADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLK 180 +Q+AA+++ ++L + +V D+E L + A TS++ K + LA + V++V Sbjct: 121 VKGYQAAAQKAQELLKTIACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSA 180 Query: 181 ISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQ 240 + D+ K VD + I++ KK G +IDDTE+I GV++ + + SA P + AKI L+ Sbjct: 181 VVDDEGK-VDKDLIKIEKKSGASIDDTELIKGVLVDKERV-SAQMPKKVTDAKIALLNCA 238 Query: 241 ISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDL 300 I + +T+ I + D ++ + +++E L ++ +IK + NVL QK I +DL Sbjct: 239 IEIKETETDAEIRITDPAKLMEFIEQEEKMLKDMVAEIKASGANVLFCQKGI-----DDL 293 Query: 301 ALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKI 360 A H+L+K I+ + +++ ++E L+K G IA I + LG A LVEE G + Sbjct: 294 AQHYLAKEGIVAARRVKKSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEERKISGDSM 353 Query: 361 VRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIE 420 + V ++ A V+++IRG +I+E R++ DA+ V+ C +++ +++GGG+ E+E Sbjct: 354 IFVEECKHPKA---VTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVE 410 Query: 421 ISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHE-NGELN 479 +S +L + A + G + + FA ALEVIP TLAENAGL++I+++ ++R+ H NG Sbjct: 411 LSMKLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKC 470 Query: 480 DGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 G++V + E +++P+ V T AI A+E + +LRIDD+ + Sbjct: 471 AGLNVFTGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAE 519 >4B2T-G nrPDB Length = 545 Score = 543 bits (1400), Expect = e-155, Method: Composition-based stats. Identities = 155/517 (29%), Positives = 292/517 (56%), Gaps = 12/517 (2%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILH 72 +E ++V+ NI AA+++AD IRT LGPK M KM+ G I+++NDG+ IL+++ + H Sbjct: 15 KRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQH 74 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSV 132 P A+ ++E+S QD E GDGTTSV+IL G +L AE L + +HPT++ +++ A + Sbjct: 75 PAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMI 134 Query: 133 DILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKI--SDENSKNVD 190 L ++ V S+R+ ++ ++S+++K++S++SS +A+D+V + + K +D Sbjct: 135 STLKKISIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEID 194 Query: 191 LNDI-RLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTE 249 + R+ K GG I+D+ ++ GV++ + + + +I L+ + K +++ Sbjct: 195 IKKYARVEKIPGGIIEDSCVLRGVMINKD-VTHPRMRRYIKNPRIVLLDSSLEYKKGESQ 253 Query: 250 NNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLN 309 +I + +IL+ E Y+ +C+ I + K +V++ +K I +DLA H+L + N Sbjct: 254 TDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGI-----SDLAQHYLMRAN 308 Query: 310 IMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNN 369 I ++ + + + +++ G + ++ E E+ +G+ + EI G + T I Sbjct: 309 ITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDEY--FTFITEC 366 Query: 370 NARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEA 429 ++++RGA+ I+ E ER+L DA+ V R ++ + L+ GGGA E+ ++ L++++ Sbjct: 367 KDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKS 426 Query: 430 RSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGE-LNDGISVRRSG 488 ++M GV+ + ++ A ALEVIP TL +N G ++I+++T LR+KH G++ Sbjct: 427 KAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGT 486 Query: 489 TTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIA 525 + E I +P+ V A E +LRIDDI Sbjct: 487 LVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIV 523 >5UYZ-A nrPDB Length = 541 Score = 541 bits (1395), Expect = e-154, Method: Composition-based stats. Identities = 188/518 (36%), Positives = 313/518 (60%), Gaps = 14/518 (2%) Query: 12 KNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAIL 71 K++ E K++I+AA++VA+ +RTSLGP G+DKM+ G++ ++NDG TIL M + Sbjct: 25 KSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVD 84 Query: 72 HPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRS 131 H +A+++VE+S +QD E GDGTT VV+L GALL AE+LL++GIHP IAD ++ AA+ + Sbjct: 85 HQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVA 144 Query: 132 VDILLEMCHK--VSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNV 189 ++ L ++ V + D E L++ A T+L SK+V+ +A +AV++VL ++D ++V Sbjct: 145 IERLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDV 204 Query: 190 DLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTE 249 D I++ KVGG ++DT++I GV++ + P + E AKI ++ PPKP T+ Sbjct: 205 DFELIKVEGKVGGRLEDTKLIKGVIVDKD-FSHPQMPKKVEDAKIAILTCPFEPPKPKTK 263 Query: 250 NNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLN 309 + + V + K E+ + ++IK+ N+ + Q +D A H L + N Sbjct: 264 HKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGF-----DDEANHLLLQNN 318 Query: 310 IMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSD--GSKIVRVTGIR 367 + V+ + EIE ++ G + + T ++LG A LV+EI K++ + + Sbjct: 319 LPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCK 378 Query: 368 NNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSK 427 N+ A V++ IRG N MII+E +RSLHDALCVIR L+++ ++ GGGA EI + +S+ Sbjct: 379 NSRA---VTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQ 435 Query: 428 EARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENG-ELNDGISVRR 486 EA ++ + + FA ALEVIP L+EN+G+N I+ +TE+R++ GI Sbjct: 436 EADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLH 495 Query: 487 SGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 GT + ++H+++ ++ I+LA++ V+ IL+IDDI Sbjct: 496 KGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 >4V8R-AE nrPDB Length = 562 Score = 539 bits (1389), Expect = e-153, Method: Composition-based stats. Identities = 187/527 (35%), Positives = 314/527 (59%), Gaps = 18/527 (3%) Query: 12 KNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAIL 71 K ++ E +K++I+AARSVA I+TSLGP+G+DK++ + GEI I+NDG TIL QM + Sbjct: 38 KKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELD 97 Query: 72 HPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRS 131 + +A++LV++S +QD E GDGTT VV+L ALL A L+ KGIHP IA+ F AAK + Sbjct: 98 NEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLA 157 Query: 132 VDILLEMCHKVSLSD----REQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSK 187 + L E C +S S+ R+ L+RAA TSL SKIVS+ A +AV++V+ + D++ K Sbjct: 158 ISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRK 217 Query: 188 NVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRK------EKAKIGLIQFQI 241 +VD + I++ +VGG+I D+++I+GV+L + P + K+ ++ Sbjct: 218 DVDFDLIKMQGRVGGSISDSKLINGVILDKD-FSHPQMPKCVLPKEGSDGVKLAILTCPF 276 Query: 242 SPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLA 301 PPKP T++ + ++ + K+ E+ + +KKA +V++ Q +D A Sbjct: 277 EPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQWGF-----DDEA 331 Query: 302 LHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIV 361 H L + ++ V+ + +E+E ++ + + + ++D+LG+ + E + +K Sbjct: 332 NHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEFGTTK-D 390 Query: 362 RVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEI 421 R+ I + TV+ +RG+N MI+DE ER+LHD+LCV+R LVK+ ++ GGGA E+ + Sbjct: 391 RMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGGAAEVTM 450 Query: 422 SRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGEL-ND 480 S +S+EA G+ + ++ FA AL+ IP TLAEN+GL+ I ++ L+SK ++ N Sbjct: 451 SLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQLKEKISNI 510 Query: 481 GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 G+ G+ + E ++ P + I LA++ + IL+ID++ S Sbjct: 511 GVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIIS 557 >4B2T-H nrPDB Length = 543 Score = 531 bits (1369), Expect = e-151, Method: Composition-based stats. Identities = 154/519 (29%), Positives = 273/519 (52%), Gaps = 18/519 (3%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILH 72 + + +NI A + +A+A+RT+LGP+GMDK+I RG+ ISNDG TILK + ++H Sbjct: 14 DSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVH 73 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSV 132 P A+ LV+++ +QD+E GDGTTSV +L L + + +G+HP II +F++A + +V Sbjct: 74 PAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAV 133 Query: 133 DILLEMCHKVSLSD----REQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKN 188 + + E+ V D R+ L + A T+LSSK++SQ +F A + VD+V+ + D Sbjct: 134 NKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDL---- 189 Query: 189 VDLNDIRLVKKVGGTIDDTEMIDGVVLTQTA--IKSAGGPTRKEKAKIGLIQFQISPPKP 246 + L I + K GG +++++++ GV +T P + I L+ ++ Sbjct: 190 LQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNPMIALLNVELELKAE 249 Query: 247 DTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLS 306 I V+ I+ E L + +KI + V+L + I D+A + + Sbjct: 250 KDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPI-----GDVATQYFA 304 Query: 307 KLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGI 366 ++ + E+++ G + + D LG + EE G + TG Sbjct: 305 DRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIGGERYNFFTGC 364 Query: 367 RNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLS 426 T ++++RG ++ETERSLHDA+ ++R +K ++AGGGA E+E+S+ L Sbjct: 365 PKAK---TCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLR 421 Query: 427 KEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRR 486 +R++ G Q + +A ALE+IP L +NAG ++ ++ +LR++H G + G+ + Sbjct: 422 DYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINT 481 Query: 487 SGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIA 525 + +E + +P +V +A+T ASE I+ +D+ Sbjct: 482 EDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETI 520 >5GW5-g nrPDB Length = 534 Score = 531 bits (1367), Expect = e-151, Method: Composition-based stats. Identities = 147/535 (27%), Positives = 288/535 (53%), Gaps = 18/535 (3%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 M A V + + ++ + +NI AA++VAD IRT LGPK M KM+ G ++++ND Sbjct: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGA-AERLLNKGIHPTI 119 GH IL+++ + HP A+ ++E+S QD E GDGTT+V+IL G +L A L+ K IHP I Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 120 IADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVL 179 I + + A +++++ ++ V + + + + S+ +K V +S + LA+D+V Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 Query: 180 KISD------ENSKNVDLN---DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKE 230 + E N +++ +R+ K GG + D+ ++ GV+L + + E Sbjct: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV-HPKMSRHIE 239 Query: 231 KAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQK 290 ++ L+ + K +++ NI + ++IL+ E + +C++I + +++ +K Sbjct: 240 NPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEK 299 Query: 291 SILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLV 350 + +DLA H+L K V++ +++ + +++ G + +E E +G+ + Sbjct: 300 GV-----SDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGL 354 Query: 351 EEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGL 410 +++ G + + + N ++++RG + I++E +R+L DA+ V R ++ L Sbjct: 355 FKVEMIGDEY--FSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSL 412 Query: 411 IAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELR 470 GGGA E+ +S +L+++A+ +EG+Q + +Q A A+E IP TL +NAG + I+++++LR Sbjct: 413 SPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR 472 Query: 471 SKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIA 525 +KH G GI + + I +P ++ ++ A E +LR+DDI Sbjct: 473 AKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 527 >3AQ1-B nrPDB Length = 500 Score = 525 bits (1352), Expect = e-149, Method: Composition-based stats. Identities = 176/485 (36%), Positives = 291/485 (60%), Gaps = 12/485 (2%) Query: 47 MIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGA 106 M+ S G+I+I+NDG TILK+M I HP A+M+VEVS QD+E GDGTT+ +L+G LL Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 107 AERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQY 166 AE L+ KG+H TII++ ++ AA++ +IL + +S D L++ A T+++ K Y Sbjct: 61 AEELIMKGVHSTIISEGYRHAAEKCREILETITIAISPDDEAALIKIAGTAITGKGAEAY 120 Query: 167 SSFLAPLAVDSVLKISDENSKNVD---LNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSA 223 L+ L V +V I +E + L +I++ K+ GG+IDD+E+IDG+V+ + Sbjct: 121 KEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKER-SHP 179 Query: 224 GGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKC 283 P + E AKI L+ + K + ++ I + QM L +E + + +K+ + Sbjct: 180 NMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKVIASGA 239 Query: 284 NVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDR 343 NV+ QK I +D+A +++ K I V+ +++ +++ LSK G I D++ T + Sbjct: 240 NVVFCQKGI-----DDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTED 294 Query: 344 LGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRC 403 +G+A LVEE + G K+ VTG +N+ A V+V++ G ++D + +L+DAL V+ Sbjct: 295 VGTAGLVEEKEVRGGKMTYVTGCQNSKA---VTVLLHGGTEHVVDSLDHALNDALHVVGV 351 Query: 404 LVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSI 463 ++++ ++ GGG+ E+E+S RLS+ A +++G + +FA ALEVIP LAENAGL+ I Sbjct: 352 VIEDGKVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPI 411 Query: 464 KVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDD 523 ++ ELRS+HE G N G++V + +E +++P+ + T AI A E ILRIDD Sbjct: 412 DIMVELRSQHEKGNKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAMEATVMILRIDD 471 Query: 524 IAFSR 528 + S+ Sbjct: 472 VVASK 476 >4B2T-A nrPDB Length = 556 Score = 520 bits (1339), Expect = e-148, Method: Composition-based stats. Identities = 168/535 (31%), Positives = 283/535 (52%), Gaps = 27/535 (5%) Query: 9 ATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQM 68 + F ++ + +R N++AA S+A+ +++SLGP G+DKM+ G++ I+NDG TILK + Sbjct: 6 SVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLL 65 Query: 69 AILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAA 128 + HP A++L E++ QD E GDGTTSVVI+ LL A+ L+ + IHPT + ++ A Sbjct: 66 EVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLAC 125 Query: 129 KRSVDILLE-MCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSK 187 K +V + E + R+ L+ AA TS+SSK++ F A L VD+VL I + + Sbjct: 126 KEAVRYISENLIINTDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIR 185 Query: 188 N---VDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPP 244 +N I ++K G + ++ +I+G L + S G P R AKI + F + Sbjct: 186 GQPRYPVNSINVLKAHGRSQMESMLINGYALNC-VVGSQGMPKRIVNAKIACLDFSLQKT 244 Query: 245 KPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHF 304 K +++ D ++D+I + E +KI NV+L I +D+ L + Sbjct: 245 KMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGI-----DDMCLKY 299 Query: 305 LSKLNIMVVKDIEREEIEFLSKGLGCKPIADI------ELFTEDRLGSADLVEEIDSDGS 358 + M V+ + + +++ ++K G ++ + E F LG A+ V + Sbjct: 300 FVEAGAMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDD 359 Query: 359 KIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPE 418 +++ I+N AR + SV++RGAN+ + DE ERSLHDALCV++ +++ + ++ GGGA E Sbjct: 360 ELI---LIKNTKARTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVE 416 Query: 419 IEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGE- 477 +S L A SM + EFA +L VIP TLA NA +S +V +LR+ H + Sbjct: 417 AALSIYLENYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQV 476 Query: 478 -------LNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIA 525 G+ + + + + +P +V ++ A+E +ILRIDD+ Sbjct: 477 NPERKNLKWIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLI 531 >5GW4-h nrPDB Length = 550 Score = 516 bits (1330), Expect = e-147, Method: Composition-based stats. Identities = 150/521 (28%), Positives = 266/521 (51%), Gaps = 16/521 (3%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILH 72 + + + +NI A +V +A++ +LGP G D +I TS + ISNDG TILK + ++H Sbjct: 18 DASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVH 77 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSV 132 P A+ LV++S AQD+E GDGTTSV IL G L+ A+ L +GI +I ++ A +V Sbjct: 78 PAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAV 137 Query: 133 DILLEMCHKVSL---SDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNV 189 + + E+ ++ S RE L R A T++SSK++ + F + VD+VL + + ++ Sbjct: 138 EKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL---DRNDL 194 Query: 190 DLNDIRLVKKVGGTIDDTEMIDGVVLTQTA--IKSAGGPTRKEKAKIGLIQFQISPPKPD 247 D I + K GG ++++ I+GV +T P + KI + ++ Sbjct: 195 DDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEK 254 Query: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSK 307 + V I+ E + +++++ N++L + I DLA F + Sbjct: 255 DNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPI-----GDLATQFFAD 309 Query: 308 LNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIR 367 NI + +++ + + +G + + LG+ L EE+ + G Sbjct: 310 RNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCP 369 Query: 368 NNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSK 427 T ++++RG +I E ERSLHDA+ +++ ++ + ++AGGGA E+E+S+ L Sbjct: 370 QAK---TCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRD 426 Query: 428 EARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRS 487 ++++ G Q I FA ALEVIP L ENAG ++I+++ +LR H GE G+ Sbjct: 427 YSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETE 486 Query: 488 GTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + + + + +P LV +A+ A+E IL +D+ ++ Sbjct: 487 NIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNK 527 >3IYF-A nrPDB Length = 521 Score = 514 bits (1323), Expect = e-146, Method: Composition-based stats. Identities = 179/529 (33%), Positives = 308/529 (58%), Gaps = 33/529 (6%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 MS + + ++ ++ NI+A R +A+ +R++LGPKGMDKM+ G+++++ND Sbjct: 1 MSQQPGVLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTND 60 Query: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTII 120 G TIL++M++ HP A+ML+EV+ Q+ E GDGTT+ V++ G LL AE LL++ +HPTI+ Sbjct: 61 GVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIV 120 Query: 121 ADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLK 180 +Q+AA+++ ++L + +V D+E L + A TS++ K + LA + V++V Sbjct: 121 VKGYQAAAQKAQELLKTIACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSA 180 Query: 181 ISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQ 240 + D+ K VD + I++ KK G +IDDTE+I GV++ + + SA P + AKI L+ Sbjct: 181 VVDDEGK-VDKDLIKIEKKSGASIDDTELIKGVLVDKERV-SAQMPKKVTDAKIALLNCA 238 Query: 241 ISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDL 300 I + L ++ +IK + NVL QK I +DL Sbjct: 239 IEETASE----------------------MLKDMVAEIKASGANVLFCQKGI-----DDL 271 Query: 301 ALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKI 360 A H+L+K I+ + +++ ++E L+K G I +I+ + LG A LVEE G + Sbjct: 272 AQHYLAKEGIVAARRVKKSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEERKISGDSM 331 Query: 361 VRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIE 420 + V ++ A V+++IRG +I+E R++ DA+ V+ C +++ +++GGG+ E+E Sbjct: 332 IFVEECKHPKA---VTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVE 388 Query: 421 ISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHE-NGELN 479 +S +L + A + G + + FA ALEVIP TLAENAGL++I+++ ++R+ H NG Sbjct: 389 LSMKLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKC 448 Query: 480 DGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 G++V + E +++P+ V T AI A+E + +LRIDD+ + Sbjct: 449 AGLNVFTGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAE 497 >4V8R-AG nrPDB Length = 590 Score = 511 bits (1316), Expect = e-145, Method: Composition-based stats. Identities = 146/589 (24%), Positives = 284/589 (48%), Gaps = 70/589 (11%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 M A V + + ++ + +NI AA++VAD IRT LGPK M KM+ G ++++ND Sbjct: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGA-AERLLNKGIHPTI 119 GH IL+++ + HP A+ ++E+S QD E GDGTT+V+IL G +L A L+ K IHP I Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 120 IADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVL 179 I + + A +++++ ++ V + + + + S+ +K V +S + LA+D+V Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 Query: 180 KISD------ENSKNVDLN---DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKE 230 + E N +++ +R+ K GG + D+ ++ GV+L + + E Sbjct: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV-HPKMSRHIE 239 Query: 231 KAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQK 290 ++ L+ + K +++ NI + ++IL+ E + +C++I + +++ +K Sbjct: 240 NPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEK 299 Query: 291 SILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGS-ADL 349 + +DLA H+L K V++ +++ + +++ G + +E E +G+ L Sbjct: 300 GV-----SDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGL 354 Query: 350 VEEIDSDGSKIVRVTGIRNNNA-------------------------------------- 371 + + + + Sbjct: 355 FKVEMIGDEYFSFLDNCKEPGSGSGWSHPQFEKGSGKRRWKKNFIAVSAANRFKKISSSG 414 Query: 372 ---------------RPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGA 416 ++++RG + I++E +R+L DA+ V R ++ L GGGA Sbjct: 415 ALGSGHHHHHHHHGSGKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGA 474 Query: 417 PEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENG 476 E+ +S +L+++A+ +EG+Q + +Q A A+E IP TL +NAG + I+++++LR+KH G Sbjct: 475 TEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQG 534 Query: 477 ELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIA 525 GI + + I +P ++ ++ A E +LR+DDI Sbjct: 535 NFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 583 >4V94-A nrPDB Length = 559 Score = 491 bits (1264), Expect = e-139, Method: Composition-based stats. Identities = 162/545 (29%), Positives = 275/545 (50%), Gaps = 35/545 (6%) Query: 7 SNATFKNKEK--PQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTI 64 S+ F EK ++R N++A +VA+ +++SLGP G+DKM+ G+ ++NDG TI Sbjct: 10 SDTLFLGGEKISGDDIRNQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATI 69 Query: 65 LKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSF 124 L + + HP ++LVE++ QD E GDGTTSVVI+ LL A L+ IHPT I F Sbjct: 70 LSLLDVQHPAGKILVELAQQQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGF 129 Query: 125 QSAAKRSVDILLE-MCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISD 183 + A + ++ + E + V +E L+ A TS+SSKI+ S F + + VD++L + Sbjct: 130 RVALREAIRFINEVLSTSVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKT 189 Query: 184 ENSKN---VDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRK--EKAKIGLIQ 238 +NSK + + ++K G + ++ ++ G L T + S P R KI + Sbjct: 190 QNSKGEIKYPVKAVNVLKAHGKSATESLLVPGYALNCT-VASQAMPKRIAGGNVKIACLD 248 Query: 239 FQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVN 298 + + I ++D Q+++I K E +L KKI A V+L K I + Sbjct: 249 LNLQKARMAMGVQINIDDPEQLEQIRKREAGIVLERVKKIIDAGAQVVLTTKGI-----D 303 Query: 299 DLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADI------ELFTEDRLGSADLVEE 352 DL L + IM V+ ++E++ +++ G ++ + E F LG D V + Sbjct: 304 DLCLKEFVEAKIMGVRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQ 363 Query: 353 IDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIA 412 + + I+ + + S+++RGAN+ +DE ERSLHD+L V++ ++ ++ Sbjct: 364 AKFSDDECI---LIKGTSKHSSSSIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVP 420 Query: 413 GGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSK 472 GGG E ++ L A ++ + EFA+AL +IP TLA NA +S ++V +LRS Sbjct: 421 GGGCVEAALNIYLDNFATTVGSREQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSY 480 Query: 473 HENGEL------------NDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILR 520 H ++ N G+ + R + +L+P + ++ A E +ILR Sbjct: 481 HAASQMAKPEDVKRRSYRNYGLDLIRGKIVDEIHAGVLEPTISKVKSLKSALEACVAILR 540 Query: 521 IDDIA 525 ID + Sbjct: 541 IDTMI 545 >4B2T-Q nrPDB Length = 548 Score = 484 bits (1246), Expect = e-137, Method: Composition-based stats. Identities = 143/540 (26%), Positives = 274/540 (50%), Gaps = 24/540 (4%) Query: 1 MSAKVPSNATFKNKEKP--------QEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSR 52 M+ VP F K +E NI A + +A RT+ GP GM+KM+ Sbjct: 1 MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHL 60 Query: 53 GEIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLN 112 ++ ++ND TIL+++ + HP A+M+V S Q+ E GDGT V++ GALL AE LL Sbjct: 61 EKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLR 120 Query: 113 KGIHPTIIADSFQSAAKRSVDILLEM--CHKVSLSDREQLVRAASTSLSSKIVSQYSSFL 170 G+ + + + ++ A K++ +IL ++ C +L D +++ TS+ SK FL Sbjct: 121 LGLSVSEVIEGYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYG-NEVFL 179 Query: 171 APLAVDSVLKISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKE 230 A L + + I +S + ++++IR+ K +G + + ++ G+V + + G T + Sbjct: 180 AKLIAQACVSIF-PDSGHFNVDNIRVCKILGSGVHSSSVLHGMVFKKE---TEGDVTSVK 235 Query: 231 KAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQK 290 AKI + +T+ +++ ++ K E + K I NV+ Sbjct: 236 DAKIAVYSCPFDGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVV---- 291 Query: 291 SILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLV 350 + V D+ALH+ +K NIM+V+ + ++ L K +G + + + +G D V Sbjct: 292 -VTGGRVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSV 350 Query: 351 EEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGL 410 + +++V + + A ++V+RG+ + ++D+ ER++ D + + L +++ L Sbjct: 351 YLSEVGDTQVVVFKHEKEDGAIS--TIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRL 408 Query: 411 IAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELR 470 + GGGA EIE++++++ + G++ + ++FA A E IP LAEN+G+ + +V+++L Sbjct: 409 VPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLY 468 Query: 471 SKHENGELNDGISVRRS--GTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + H+ G N G+ + + E +L L AI LA+ ++LR+D I ++ Sbjct: 469 AVHQEGNKNVGLDIEAEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAK 528 >4B2T-B nrPDB Length = 535 Score = 484 bits (1246), Expect = e-137, Method: Composition-based stats. Identities = 152/521 (29%), Positives = 272/521 (52%), Gaps = 20/521 (3%) Query: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTS--RGEIIISNDGHTILKQMAI 70 ++E+ + R ++ I A ++ D ++++LGPKGMDK++ +S ++++NDG TILK + + Sbjct: 17 DEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGV 76 Query: 71 LHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKR 130 +P A++LV++S QD E GDGTTSV +L LL AE L+ K IHP I ++ A K Sbjct: 77 DNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKA 136 Query: 131 SVDILLEMCHKVSLSD---REQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSK 187 + LL + R+ L+ A T+LSSK+++ + LAV++VL++ Sbjct: 137 ARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSG-- 194 Query: 188 NVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPD 247 +L I ++KK+GG++ D+ + +G +L + P R E AKI + + K Sbjct: 195 --NLEAIHVIKKLGGSLADSYLDEGFLLDKKI--GVNQPKRIENAKILIANTGMDTDKIK 250 Query: 248 -TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLS 306 + + V+ ++ +I E+ + ++I K N I R + + Sbjct: 251 IFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCF-----INRQLIYNYPEQLFG 305 Query: 307 KLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGI 366 +M ++ + +E L+ G + + + +LGS L+EE+ K++ +G+ Sbjct: 306 AAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGV 365 Query: 367 RNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLS 426 A ++V+RGA I+DE ERSLHDALCV+ VK+ + GGG E+ ++ ++ Sbjct: 366 ALGEA---CTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVT 422 Query: 427 KEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRR 486 + A G +A + +A AL ++PT +A+NAG +S +V +LR+ H G+ G+ ++ Sbjct: 423 QLASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGKTTAGLDMKE 482 Query: 487 SGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 + I + V + A+E + ILR+D+I + Sbjct: 483 GTIGDMSVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKA 523 >4V8R-AB nrPDB Length = 527 Score = 481 bits (1239), Expect = e-136, Method: Composition-based stats. Identities = 160/521 (30%), Positives = 284/521 (54%), Gaps = 20/521 (3%) Query: 14 KEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKT-SRGEIIISNDGHTILKQMAILH 72 +E+ + R + + A +V D ++++LGPKGMDK++++ S +++NDG TILK + + + Sbjct: 12 EERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDN 71 Query: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNK-GIHPTIIADSFQSAAKRS 131 P A++LV +S QD E GDGTTSV +L+ LL AE+L+++ IHP I + ++ A+ + Sbjct: 72 PAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAA 131 Query: 132 VDILLEMCHKVS---LSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKN 188 +D L + S RE L+ A T+LSSKI+SQ A LA +++L++ + Sbjct: 132 LDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRLKG----S 187 Query: 189 VDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPD- 247 +L I+++K +GG + D+ + +G +L + P R E AKI + + K Sbjct: 188 TNLEHIQIIKILGGKLSDSFLDEGFILAKKF--GNNQPKRIENAKILIANTTLDTDKVKI 245 Query: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSK 307 V+ ++ ++ K ER + N KI K N I R + D + Sbjct: 246 FGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTF-----INRQLIYDYPEQLFTD 300 Query: 308 LNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIR 367 L I ++ + E +E L+ G + ++ + ++ +LG D++EEI ++ +G + Sbjct: 301 LGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCK 360 Query: 368 NNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSK 427 A ++V+RGA + +DE ERSLHDAL V+ KE + GGG E+ +S+ + Sbjct: 361 AGEA---CTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDT 417 Query: 428 EARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRS 487 EA++++G ++ + FA AL +PT LA+NAG +S ++V++LRS NG G+ + Sbjct: 418 EAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSGLDLNNG 477 Query: 488 GTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + + I++ + + ++ ASE + +LR+D+I +R Sbjct: 478 TIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRAR 518 >4B2T-Z nrPDB Length = 531 Score = 480 bits (1236), Expect = e-136, Method: Composition-based stats. Identities = 140/517 (27%), Positives = 257/517 (49%), Gaps = 10/517 (1%) Query: 15 EKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV 74 + Q NI AAR + D +RT+LGPKG KM+ + G+I ++ DG+ +L +M I HP Sbjct: 14 ARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPT 73 Query: 75 ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDI 134 A ++ +V+ AQD GDGTTS V++ G LL A+ +++G+HP II + F++A ++++ Sbjct: 74 ASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQF 133 Query: 135 LLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDI 194 L ++ + DRE L+ A TSL +K+ ++ + L VDS+L I ++ +DL + Sbjct: 134 LEQVKVSKEM-DRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEP-IDLFMV 191 Query: 195 RLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIV 254 +++ + DT +I G+VL A + R E A I + K + + Sbjct: 192 EIMEMKHKSETDTSLIRGLVLDHGA-RHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFY 250 Query: 255 NDYRQMDKILKEERAYLLNICKKIKKAKCNVLL-IQKS---ILRDAVNDLALHFLSKLNI 310 + +K++K ER ++ + KKI + K V K I + ++ +L L+K I Sbjct: 251 KSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGI 310 Query: 311 MVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNN 370 + ++ +R +E L+ G + ++ D LG A LV E K + N Sbjct: 311 IALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPR 370 Query: 371 ARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEAR 430 +V+++I+G N + + + ++ D L ++ + + ++ G GA E+ ++ L K Sbjct: 371 ---SVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALVKYKP 427 Query: 431 SMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTT 490 S++G Q FA AL +IP LA+N+G + + + +++++H G+ + Sbjct: 428 SVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGEPM 487 Query: 491 NTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 E I V + + +IL +D+I + Sbjct: 488 VAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRA 524 >5GW5-q nrPDB Length = 568 Score = 471 bits (1211), Expect = e-133, Method: Composition-based stats. Identities = 146/555 (26%), Positives = 271/555 (48%), Gaps = 34/555 (6%) Query: 1 MSAKVPSNAT---FKNKEKPQEVRKANII----AARSVADAIRTSLGPKGMDKMIKTSRG 53 MS ++P N FK II A R + TS+GP G +K+I G Sbjct: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 Query: 54 EIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNK 113 +III+ND T+L+++ I+HP ++LV + Q + GDGT V+IL G LL +E+L++ Sbjct: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 Query: 114 GIHPTIIADSFQSAAKRSVDILLEMC--HKVSLSDREQLVRAASTSLSSKIVSQYSSFLA 171 G+ I + A K ++ L EM +D+ +L++ +SSK L+ Sbjct: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILS 179 Query: 172 PLAVDS---VLKISDENS--KNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGP 226 L ++ VL ++ + +++ IR+VK +GG++ ++ +I G+V + Sbjct: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSL 239 Query: 227 TRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVL 286 + +K K+ + + +T+ +++++ ++M K E + + K+I + Sbjct: 240 SEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECI 299 Query: 287 LIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGS 346 + V +LALH+L++ I+V+K + E+ L + G P+ + T + LG Sbjct: 300 -----VAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGL 354 Query: 347 ADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVK 406 + V+ ++ G ++ + +R T ++++RGA +D+ ER++ D + ++ L+K Sbjct: 355 VETVKTMEIGGDRVTVFKQEQGEISR-TSTIILRGATQNNLDDIERAIDDGVAAVKGLMK 413 Query: 407 ERG--LIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIK 464 G L+ G GA EIE+ R++K G+ ++FA A EV+P TLAE AGL+ + Sbjct: 414 PSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNE 473 Query: 465 VVTELRSKH--------ENGELNDGISVR---RSGTTNTYEEHILQPVLVSTSAITLASE 513 V+ L + H + L G+ + G + EE+I + AI +A+E Sbjct: 474 VLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATE 533 Query: 514 CVKSILRIDDIAFSR 528 ++L ID I ++ Sbjct: 534 AATTVLSIDQIIMAK 548 >5GW5-z nrPDB Length = 546 Score = 469 bits (1207), Expect = e-132, Method: Composition-based stats. Identities = 143/527 (27%), Positives = 257/527 (48%), Gaps = 19/527 (3%) Query: 16 KPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVA 75 + K N+ +A + + T+LGPKG KM+ G I ++ DG +L +M I P A Sbjct: 14 RRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTA 73 Query: 76 RMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDIL 135 ++ +AAQD GDGTT+VV L G LL A R + +G+HP II D F+ A K S+ L Sbjct: 74 VLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFL 133 Query: 136 LEMCHKVS--LSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLND 193 E + +DRE L++ A +SL +K+ + + L P+ D+VL + D + N+DL+ Sbjct: 134 DEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHM 193 Query: 194 IRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNII 253 + +++ + DT I G+VL + PTR + A + ++ + K + + Sbjct: 194 VEIMQMQHLSPKDTTFIKGLVLDHGG-RHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFF 252 Query: 254 VNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKS-----ILRDAVNDLALHFLSKL 308 + Q DK+ ER ++ KKI K V + I + ++ ++L +K Sbjct: 253 YSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKH 312 Query: 309 NIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRN 368 NI+ ++ +R +E L G + +E + LG + LV + K VT Sbjct: 313 NILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVT---E 369 Query: 369 NNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKE 428 N + +++I+G+ + + +T+ ++ D L + ++K++ +I G GA I +SR L Sbjct: 370 NTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSA 429 Query: 429 ARSM---EGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND----- 480 + +G + FA AL VIP TL +N+G + + V+ + + ++ + +D Sbjct: 430 NMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYV 489 Query: 481 GISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFS 527 G+ + + + E I V +AIT A+ ++L D++ + Sbjct: 490 GVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRA 536 >5X9V-A nrPDB Length = 521 Score = 388 bits (998), Expect = e-108, Method: Composition-based stats. Identities = 128/521 (24%), Positives = 240/521 (46%), Gaps = 33/521 (6%) Query: 15 EKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV 74 E+ + +N A +++ + SLGPKG+D M+ GE++++NDG TIL M HP Sbjct: 11 EERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPA 70 Query: 75 ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDI 134 ARM+V ++ AQ+ E GDGTT+ +L GAL+ + KG+ + + A ++ + Sbjct: 71 ARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFL 130 Query: 135 LLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDE-NSKNVDLND 193 + + KV ++L+ AA KI + +A + D+ + D+ L D Sbjct: 131 IRKNAIKVGSITDDRLLAAA------KIAGRGDERVAAILRDAAAMLEDKLQDPGFKLAD 184 Query: 194 IRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNII 253 + L K DT +I GVV+ ++ + G +E ++ ++ + P + + E Sbjct: 185 LVLAKVG----ADTTLIPGVVINKSPLWEEGSQKLQE-VRLLVLDDGLYPEEVEEEA--- 236 Query: 254 VNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVV 313 + ++ LK ++ + N+ KK+K+ ++L+ + I +D+A F + IMV+ Sbjct: 237 LASEAGFEQYLKNQKIFQENL-KKLKELGVKLILLTRGI-----SDIAEEFCYENEIMVI 290 Query: 314 KDIEREEIEFLSKGLGCKPIADIELFTE-----DRLGSADLVEEIDSDGSKIVRVTGIRN 368 I ++E++ + + G + L LG A + T I Sbjct: 291 TRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTCFY-----DSRLDFTIIEG 345 Query: 369 NNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKE 428 + T +V+I A + ++DE ER DA + G++ GGGA + +SR + Sbjct: 346 GAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRS-GVLPGGGAFFLYLSREVESL 404 Query: 429 ARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKH-ENGELNDGISVRRS 487 + G++++ F+ AL+V +AENAG N ++ + +L + + G+ Sbjct: 405 KNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETG 464 Query: 488 GTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + ++ P V A+ ASE S+L+I+ I + Sbjct: 465 EFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTIIKMK 505 >1IOK-A nrPDB Length = 545 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 115/585 (19%), Positives = 241/585 (41%), Gaps = 117/585 (20%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 M+AK F + + + ++ NI+A DA++ +LGPKG + +I S G I+ D Sbjct: 1 MAAK---EVKFNSDARDRMLKGVNILA-----DAVKVTLGPKGRNVVIDKSFGAPRITKD 52 Query: 61 GHTILKQMAILHPV----ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIH 116 G ++ K++ + A+M+ EV++ + EAGDGTT+ +L A++ + + G++ Sbjct: 53 GVSVAKEIELSDKFENMGAQMVREVASRTNDEAGDGTTTATVLAQAIVREGLKAVAAGMN 112 Query: 117 PTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVD 176 P + A + V+ + V +D ++ + + S + + SF+ + Sbjct: 113 PMDLKRGIDVATAKVVEAIKSAARPV--NDSSEVAQVGTISANGE------SFIGQQIAE 164 Query: 177 SVLKISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKS------AGGPTRKE 230 ++ ++ +E V+ N G + E+++G+ + + E Sbjct: 165 AMQRVGNEGVITVEENK--------GMETEVEVVEGMQFDRGYLSPYFVTNADKMIAELE 216 Query: 231 KAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQK 290 A I L + ++S +P ++ + + + +++ +L++ + Sbjct: 217 DAYILLHEKKLSSLQP------------------------MVPLLESVIQSQKPLLIVAE 252 Query: 291 SILRDAVNDLALHFL-SKLNIMVVK-----DIEREEIEFLSKGLGCKPIAD-----IELF 339 + +A+ L ++ L L I VK D + ++ ++ G + I++ +E Sbjct: 253 DVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAILTGGQVISEDLGMKLENV 312 Query: 340 TEDRLGSADLVEEIDSDGSKIV-----------RVTGIRNNNARPT-------------- 374 T D LG A V I+ D + IV RV+ IR T Sbjct: 313 TIDMLGRAKKV-SINKDNTTIVDGAGEKAEIEARVSQIRQQIEETTSDYDREKLQERVAK 371 Query: 375 -----VSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEA 429 + + G + + E + + DAL R V+E G++ GGG L + A Sbjct: 372 LAGGVAVIRVGGMTEIEVKERKDRVDDALNATRAAVQE-GIVVGGGV-------ALVQGA 423 Query: 430 RSMEGVQAFIWQEFA------SALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGIS 483 + +EG+ + A ALE +AENAG++ V ++R E+ + G + Sbjct: 424 KVLEGLSGANSDQDAGIAIIRRALEAPMRQIAENAGVDGAVVAGKVR---ESSDKAFGFN 480 Query: 484 VRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + + ++ ++ P V +A+ A+ ++ + + + Sbjct: 481 AQTEEYGDMFKFGVIDPAKVVRTALEDAASVAGLLITTEAMIAEK 525 >4V4O-A nrPDB Length = 543 Score = 231 bits (588), Expect = 7e-61, Method: Composition-based stats. Identities = 108/562 (19%), Positives = 220/562 (39%), Gaps = 96/562 (17%) Query: 18 QEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV--- 74 + R+A +VA+A++ +LGP+G + +++ G I+ DG T+ K++ + + Sbjct: 9 EAARRALERGVNAVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENI 68 Query: 75 -ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVD 133 A++L EV++ + AGDGTT+ +L A++ + + G +P + + A + +V+ Sbjct: 69 GAQLLKEVASKTNDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEAAVE 128 Query: 134 ILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLND 193 + + V DR+ + A+ S + V L D++ K+ E V+ + Sbjct: 129 KIKALAIPV--EDRKAIEEVATISANDPEVG-------KLIADAMEKVGKEGIITVEESK 179 Query: 194 IRLVKKVGGTIDDTEMIDGVVLTQTAIKS------AGGPTRKEKAKIGLIQFQISPPKPD 247 + + ++G + I E A I +++ Sbjct: 180 --------SLETELKFVEGYQFDKGYISPYFVTNPETMEAVLEDAFILIVE--------- 222 Query: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFL-- 305 V++ R++ IL +++ + +L+I + + +A+ L ++ L Sbjct: 223 ----KKVSNVRELLPIL-----------EQVAQTGKPLLIIAEDVEGEALATLVVNKLRG 267 Query: 306 ----SKLNIMVVKDIEREEIEFLSKGLGCKPIAD-----IELFTEDRLGSADLVEEIDSD 356 + + D +E ++ ++ G I++ +E T LG A+ V I D Sbjct: 268 TLSVAAVKAPGFGDRRKEMLKDIAAVTGGTVISEELGFKLENATLSMLGRAERVR-ITKD 326 Query: 357 GSKIV-----------RVTGIRNNNARP-------------------TVSVVIRGANNMI 386 + IV R+ GI+ + + A Sbjct: 327 ETTIVGGKGKKEDIEARINGIKKELETTDSEYAREKLQERLAKLAGGVAVIRVGAATETE 386 Query: 387 IDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASA 446 + E + DAL R V+E G++ GGG + + + + +EG +A + A Sbjct: 387 LKEKKHRFEDALNATRAAVEE-GIVPGGGVTLLRAISAVEELIKKLEGDEATGAKIVRRA 445 Query: 447 LEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTS 506 LE +AENAG +V ++ + E G + + E I+ P V+ S Sbjct: 446 LEEPARQIAENAGYEGSVIVQQILA--ETKNPRYGFNAATGEFVDMVEAGIVDPAKVTRS 503 Query: 507 AITLASECVKSILRIDDIAFSR 528 A+ A+ IL + + + Sbjct: 504 ALQNAASIGALILTTEAVVAEK 525 >4AAR-A nrPDB Length = 548 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 109/564 (19%), Positives = 226/564 (40%), Gaps = 94/564 (16%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 M+AK + F N + + +R N++A DA++ +LGPKG + ++ S G I+ D Sbjct: 1 MAAK---DVKFGNDARVKMLRGVNVLA-----DAVKVTLGPKGRNVVLDKSFGAPTITKD 52 Query: 61 GHTILKQMAILHPV----ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIH 116 G ++ +++ + A+M+ EV++ + AGDGTT+ +L A++ + + G++ Sbjct: 53 GVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMN 112 Query: 117 PTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVD 176 P + A +V+ L + V SD + + + + S +S + L + Sbjct: 113 PMDLKRGIDKAVTAAVEELKALS--VPCSDSKAIAQVGTISANS------DETVGKLIAE 164 Query: 177 SVLKISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGL 236 ++ K+ E V+ G D+ ++++G+ + + + A Sbjct: 165 AMDKVGKEGVITVEDGT--------GLQDELDVVEGMQFDRGYLSPYFINKPETGA---- 212 Query: 237 IQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDA 296 + E+ I+ +++ I + +L + + + KA +L+I + + +A Sbjct: 213 ---------VELESPFILLADKKISNIRE-----MLPVLEAVAKAGKPLLIIAEDVEGEA 258 Query: 297 VNDLALH------FLSKLNIMVVKDIEREEIEFLSKGLGCKPIA-----DIELFTEDRLG 345 + L ++ ++ + D + ++ ++ G I+ ++E T + LG Sbjct: 259 LATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLG 318 Query: 346 SADLVEEIDSDGSKIV-----------RVTGIRNNNARPT-------------------V 375 A V I+ D + I+ RV IR T Sbjct: 319 QAKRVV-INKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVA 377 Query: 376 SVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGV 435 + + A + + E + + AL R V+E G++AGGG I ++ +L+ E Sbjct: 378 VIKVGAATEVEMKEKKARVEAALHATRAAVEE-GVVAGGGVALIRVASKLADLRGQNED- 435 Query: 436 QAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEE 495 Q + A+E + N G V ++ G+ N G + N + Sbjct: 436 QNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKG----GDGNYGYNAATEEYGNMIDM 491 Query: 496 HILQPVLVSTSAITLASECVKSIL 519 IL P V+ SA+ A+ ++ Sbjct: 492 GILDPTKVTRSALQYAASVAGLMI 515 >5DA8-A nrPDB Length = 545 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 106/546 (19%), Positives = 208/546 (38%), Gaps = 85/546 (15%) Query: 19 EVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV---- 74 E R + +A+A++ +LGP G + +I G + DG T+ K++ ++ PV Sbjct: 11 EARTKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMG 70 Query: 75 ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDI 134 A+M+ EV++ AGDGTT+ +L A+ + + G P + A K V Sbjct: 71 AQMVREVASKTSDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAE 130 Query: 135 LLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDI 194 L + + S ++++ + + S + + L +++ K+ + V+ Sbjct: 131 LRNISRSI--SGKKEIAQVGTISAN------NDPEIGELIAEAMDKVGKDGVITVEEAK- 181 Query: 195 RLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIV 254 G + ++++G+ + + + + I Sbjct: 182 -------GMETELKVVEGMQFDRGYLS----------PYFVTNSETMEAELDEALILIHD 224 Query: 255 NDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFL-SKLNIMVV 313 M ++L I +K ++ +L+I + I +A+ L ++ L L + V Sbjct: 225 KKISNMKELLP--------ILEKAAQSGRPLLIIAEDIEGEALATLVVNKLRGTLKVAAV 276 Query: 314 K-----DIEREEIEFLSKGLGCKPIAD-----IELFTEDRLGSADL----------VEEI 353 K D + +E ++ G I++ +E T LG A VE Sbjct: 277 KAPGFGDRRKAMLEDIAILTGGTVISEEKGYKLENATMAYLGQAARITIDKDNTTIVEGK 336 Query: 354 DSDGSKIVRVTGIRNNNARPT------------------VSVV-IRGANNMIIDETERSL 394 R+ I+ + T V+V+ I + + + E + + Sbjct: 337 GKQEEIKARINEIKGQIEKSTSDYDTEKLQERLAKLSGGVAVLKIGASTEVEMKEKKARV 396 Query: 395 HDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTL 454 DAL R V+E G++ GGG I ++ L+K A + Q + ALE + Sbjct: 397 EDALHATRAAVQE-GIVVGGGVALIRAAKGLAK-AVADNEDQKTGIEIIRRALEEPLRQI 454 Query: 455 AENAG-LNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASE 513 N G + V+ +++ N E + G + R N E ++ P V+ SA+ A+ Sbjct: 455 VANTGTTDGAVVLEKVK----NAEGDYGFNARTEQYENLIEAGVVDPTKVTRSALENAAS 510 Query: 514 CVKSIL 519 +L Sbjct: 511 VASILL 516 >4PJ1-A nrPDB Length = 558 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 95/562 (16%), Positives = 213/562 (37%), Gaps = 94/562 (16%) Query: 4 KVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHT 63 + F + ++ +++A DA+ ++GPKG +I+ S G ++ DG T Sbjct: 27 GSAKDVKFGADARALMLQGVDLLA-----DAVAVTMGPKGRTVIIEQSWGSPKVTKDGVT 81 Query: 64 ILKQMAILHPV----ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTI 119 + K + + A+++ +V+ + EAGDGTT+ +L ++ ++KG +P Sbjct: 82 VAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVE 141 Query: 120 IADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVL 179 I A + L + V+ E++ + A+ S + + + D++ Sbjct: 142 IRRGVMLAVDAVIAELKKQSKPVTTP--EEIAQVATISANG------DKEIGNIISDAMK 193 Query: 180 KISDENSKNVDLNDIRLVKKVGGTIDDT-EMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQ 238 K+ + V K G T++D E+I+G+ + I T Sbjct: 194 KVGRKGVITV---------KDGKTLNDELEIIEGMKFDRGYISPYFINTS---------- 234 Query: 239 FQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVN 298 K + ++ ++ +++ I ++ + + +++I + + +A++ Sbjct: 235 ---KGQKCEFQDAYVLLSEKKISSIQS-----IVPALEIANAHRKPLVIIAEDVDGEALS 286 Query: 299 DLALHFL-SKLNIMVVK-----DIEREEIEFLSKGLGCKPIA------DIELFTEDRLGS 346 L L+ L L ++ VK D + +++ ++ G ++E LG Sbjct: 287 TLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGK 346 Query: 347 ADLVEEIDSDGSKIVRVTGIRNNNARPTVSVV---------------------------- 378 V + D + +++ G + + ++ Sbjct: 347 VGKVI-VTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAV 405 Query: 379 --IRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQ 436 + G +++ ++E + + DAL R V+E G++ GGG + L + E Q Sbjct: 406 LKVGGTSDVEVNEKKDRVTDALNATRAAVEE-GIVLGGGCALLRCIPALDSLTPANED-Q 463 Query: 437 AFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEH 496 + L++ T+A+NAG+ +V ++ G N E+ Sbjct: 464 KIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIM----QSSSEVGYDAMAGDFVNMVEKG 519 Query: 497 ILQPVLVSTSAITLASECVKSI 518 I+ P V +A+ A+ + Sbjct: 520 IIDPTKVVRTALLDAAGVASLL 541 >1SJP-A nrPDB Length = 504 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 97/521 (18%), Positives = 194/521 (37%), Gaps = 86/521 (16%) Query: 52 RGEIIISNDGHTILKQMAILHPV----ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAA 107 G I+NDG +I K++ + P A ++ EV+ D AGDGTT+ +L AL+ Sbjct: 1 WGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREG 60 Query: 108 ERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYS 167 R + G +P + + A ++ + LL+ +V + + A+T+ +S Sbjct: 61 LRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKE-----QIAATAA----ISAGD 111 Query: 168 SFLAPLAVDSVLKISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPT 227 + L +++ K+ +E V+ ++ + G + Sbjct: 112 QSIGDLIAEAMDKVGNEGVITVEESN--TFGLQLELTEGMRFDKGYISGYFVTDPERQEA 169 Query: 228 RKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLL 287 E I L+ ++S K LL + +K+ A +L+ Sbjct: 170 VLEDPYILLVSSKVSTVKD------------------------LLPLLEKVIGAGKPLLI 205 Query: 288 IQKSILRDAVNDLALHFL------SKLNIMVVKDIEREEIEFLSKGLGCKPIA-----DI 336 I + + +A++ L ++ + + D + ++ ++ G + I+ + Sbjct: 206 IAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTL 265 Query: 337 ELFTEDRLGSADLV---------------------------EEIDSDGSKIVRVT-GIRN 368 E LG A V +EI++ S R R Sbjct: 266 ENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERL 325 Query: 369 NNARPTVSVVIRG-ANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSK 427 V+V+ G A + + E + + DA+ + V+E G++AGGG ++ + L + Sbjct: 326 AKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEE-GIVAGGGVTLLQAAPTLDE 384 Query: 428 EARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRS 487 +EG +A ALE +A N+GL V ++R+ G++ + Sbjct: 385 L--KLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPA----GHGLNAQTG 438 Query: 488 GTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR 528 + + PV V+ SA+ A+ L + + + Sbjct: 439 VYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADK 479 >1GN1-A nrPDB Length = 178 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 89/180 (49%), Gaps = 8/180 (4%) Query: 204 IDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKI 263 ++D+ ++ GV++ + + + +I L+ + K +++ +I + +I Sbjct: 1 MEDSCVLRGVMINKD-VTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRI 59 Query: 264 LKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEF 323 L+ E Y+ +C+ I + K +V++ +K I +DLA H+L + N+ ++ + + + Sbjct: 60 LQMEEEYIHQLCEDIIQLKPDVVITEKGI-----SDLAQHYLMRANVTAIRRVRKTDNNR 114 Query: 324 LSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGAN 383 +++ G + ++ E ED +G+ + EI G + T I + ++++RGA+ Sbjct: 115 IARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEY--FTFITDCKDPKACTILLRGAS 172 >1E0R-B nrPDB Length = 159 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 43/159 (27%), Positives = 84/159 (52%), Gaps = 6/159 (3%) Query: 210 IDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERA 269 ++G+++ + + G P + AKI L+ + KP+ + N+ + D + K L +E Sbjct: 1 MNGIIVDKEKV-HPGMPDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEEN 59 Query: 270 YLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLG 329 L + KIK NV++ QK I +D+A H+LS+ I V+ +++ +++ L+K G Sbjct: 60 MLREMVDKIKSVGANVVITQKGI-----DDMAQHYLSRAGIYAVRRVKKSDMDKLAKATG 114 Query: 330 CKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRN 368 ++ I+ + LG+A+ VE++ + VTG +N Sbjct: 115 ASIVSTIDEISSSDLGTAERVEQVKVGEDYMTFVTGSKN 153 >1ASS-A nrPDB Length = 159 Score = 162 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 47/159 (29%), Positives = 83/159 (52%), Gaps = 6/159 (3%) Query: 210 IDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERA 269 + G+V+ + + S P + AKI LI + K + E + ++D ++ L +E Sbjct: 1 MSGIVIDKEKVHSK-MPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETN 59 Query: 270 YLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLG 329 + +KIKK+ NV+L QK I +D+A H+L+K I V+ +++ ++E L+K G Sbjct: 60 TFKQMVEKIKKSGANVVLCQKGI-----DDVAQHYLAKEGIYAVRRVKKSDMEKLAKATG 114 Query: 330 CKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRN 368 K + D++ T LG A+ VEE ++ V G +N Sbjct: 115 AKIVTDLDDLTPSVLGEAETVEERKIGDDRMTFVMGCKN 153 >5CDI-A nrPDB Length = 552 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 97/533 (18%), Positives = 186/533 (34%), Gaps = 36/533 (6%) Query: 15 EKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPV 74 K + K +A + ++GPKG + ++++ G I NDG TI +++ + PV Sbjct: 8 NKDMQALKRMQAGVDKLATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPV 67 Query: 75 ----ARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKR 130 A ++ + +A + AGDGTT+ +L+ A + ++++ G +P + + + Sbjct: 68 ENIGATLVRQAAARTNDTAGDGTTTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTVQE 127 Query: 131 SVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVD 190 V L +M V + L A S + L D++ K+ ++ Sbjct: 128 LVKELRKMSSVVQT--DKDLANVACVSAGGNTD------IGSLISDAMAKVGRTGVVTME 179 Query: 191 LNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPK---PD 247 + V ++ + G E KI L+ +IS + Sbjct: 180 EGKTAEDQLV--FVEGMQFERGYTSPYFVTDPERMICEYENCKILLVDKKISTARDIITI 237 Query: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSK 307 E+ I N + E+ A + K++ V + + + Sbjct: 238 LESAIRGNYPLLIMAEEVEQEALATLVVNKLRGTLKVVAIKAPGF-GERRSSYLEDIAIL 296 Query: 308 LNIMVVKDIEREEIEFLS---KGLGCKPIADIELFT--------EDRLGSADLVEEIDSD 356 VV+D +E + G K E T D + + Sbjct: 297 TGGTVVRDEMGVSLEQATDAVLGTAAKITITKERTTVVGDGSTAADVAARVKQIRNLQMQ 356 Query: 357 GSKIVRVTGIRNNNARPT---VSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAG 413 + ++ AR + + + + E + + DAL R V+E G++ G Sbjct: 357 TDQDYEREKLQERIARLSGGVAIIQVGAQTETELKEKKLRVEDALNATRAAVEE-GVVPG 415 Query: 414 GGAPEIEISRRLSKEARSMEGVQ-AFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSK 472 GG + +S ++ R M + AL +A+NAG+N V+ E+ Sbjct: 416 GGCTLLRLSEKVDVIKRRMTDPEQQMGADIIKRALCYPIKLIAQNAGVNGSVVMNEVMKN 475 Query: 473 HENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIA 525 + G + N E I+ P V ++ A K+ L D + Sbjct: 476 LDRPH--YGYNAATDSFENLMETGIIDPSKVVRCSMENAVSVAKTFLLADVVV 526 >3E0V-A nrPDB Length = 539 Score = 41.5 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 11/89 (12%) Query: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMI---------KTS 51 +SAK + F ++ + + I +A V D +R +LGPKG D MI + Sbjct: 230 VSAKDRVDLQFGVEQGVDMIFASFIRSAEQVGD-VRKALGPKGRDIMIICKIENHQGVQN 288 Query: 52 RGEIIISNDGHTILK-QMAILHPVARMLV 79 II +DG + + + + P +++V Sbjct: 289 IDSIIEESDGIMVARGDLGVEIPAEKVVV 317 >3LXD-A nrPDB Length = 415 Score = 39.6 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 75/216 (34%), Gaps = 32/216 (14%) Query: 282 KCNVLLIQKSILRDAVNDLALHFLSKLNIM---VVKDIEREEIEFLSKGLGCKPIADIEL 338 +++ ++ + L+ +L++ ++ + E + + LG + ++ Sbjct: 35 GRVLVIGREPEIPYERPPLSKEYLAREKTFERICIRPAQFWEDKAVEMKLGAEVVSLDPA 94 Query: 339 FTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDAL 398 +LG +E K++ TG + V + G + E + D L Sbjct: 95 AHTVKLGDGSAIEY-----GKLIWATG-GDPRRLSCVGADLAGV--HAVRTKEDA--DRL 144 Query: 399 CVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENA 458 + ++ GGG +E + L+K ++ LE +P LA A Sbjct: 145 MAELDAGAKNAVVIGGGYIGLEAAAVLTKFGVNVT------------LLEALPRVLARVA 192 Query: 459 GLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYE 494 G + ++E + G+ +R + E Sbjct: 193 G----EALSEFY---QAEHRAHGVDLRTGAAMDCIE 221 >3BWN-A nrPDB Length = 391 Score = 31.5 bits (70), Expect = 0.97, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 22/48 (45%), Gaps = 3/48 (6%) Query: 389 ETERSLHDALCVIRC-LVKERGLIAGGGAPEI--EISRRLSKEARSME 433 E E ++ D V+ ++R ++ G G+ ++ LS ARS Sbjct: 72 ELEDAIKDLHGVVGNAATEDRYIVVGTGSTQLCQAAVHALSSLARSQP 119 >5T6O-A nrPDB Length = 389 Score = 30.8 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 26/68 (38%), Gaps = 7/68 (10%) Query: 274 ICKKIKKAKCNVLLIQK-----SILRDAVNDLALHFLSKLNIMVVKDIEREE-IEFLSKG 327 + + + + V L+ S+ +D H + I V +DI ++ I L Sbjct: 61 LVRHVVEQGHTVFLVSWRNPDASMAGSTWDDYIEHAAIRA-IEVARDISGQDKINVLGFA 119 Query: 328 LGCKPIAD 335 +G ++ Sbjct: 120 VGGTIVST 127 >1QH8-B nrPDB Length = 519 Score = 30.4 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 24/71 (33%), Gaps = 3/71 (4%) Query: 380 RGANNMIIDETERSLHDALCVIRCLVKERGLI---AGGGAPEIEISRRLSKEARSMEGVQ 436 G + E ++ L L+K + ++ A E+ I L+ + V Sbjct: 270 GGTTQQEMKEAPDAIDTLLLQPWQLLKSKKVVQEMWNQPATEVAIPLGLAATDELLMTVS 329 Query: 437 AFIWQEFASAL 447 + A AL Sbjct: 330 QLSGKPIADAL 340 >4OTL-A nrPDB Length = 423 Score = 30.0 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 31/206 (15%), Positives = 68/206 (33%), Gaps = 11/206 (5%) Query: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSK 307 ++ I D I ++E + + I + + N A + K Sbjct: 13 AQSTIANVDPEIFAAI-EQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGK 71 Query: 308 L---NIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVT 364 V +E+ I+ + + G + + + + G I+ ++ Sbjct: 72 RYYGGCEYVDVVEQLAIDRVKQLFGAEAANV--QPNSGSQANQGVFFAMLKPGDTIMGMS 129 Query: 365 GIRNNNARPTVSVVIRGA----NNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIE 420 + V + G + ++E E +DA + K + ++AG A ++ Sbjct: 130 LAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYDAAEKLANEHKPKLIVAGASAFALK 189 Query: 421 IS-RRLSKEARSMEGVQAFIWQEFAS 445 I RL+K A+S+ +A Sbjct: 190 IDFERLAKIAKSVGAYLMVDMAHYAG 215 >6ESQ-A nrPDB Length = 392 Score = 30.0 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 12/65 (18%), Positives = 23/65 (35%), Gaps = 1/65 (1%) Query: 160 SKIVSQYSSFLAPLAVDS-VLKISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQT 218 +K + L V++ V I D N D++ + + GG E I ++ Sbjct: 12 TKFGELWEDSFRDLIVEAGVKAIKDANVDGGDIDAMYIGNMSGGLFVGQEHIASLIADHA 71 Query: 219 AIKSA 223 + Sbjct: 72 GLNPV 76 >5NYW-A nrPDB Length = 251 Score = 29.6 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 11/67 (16%), Positives = 20/67 (29%), Gaps = 5/67 (7%) Query: 457 NAGLNSIKVVTELRSKHENGELN-----DGISVRRSGTTNTYEEHILQPVLVSTSAITLA 511 NAG++ I +L + GE G + + L P + + Sbjct: 21 NAGVDHISTFRKLHLFQQPGERTLVVQSAGNLATTQSIVSLLQRRCLDPEQTNLMNVASM 80 Query: 512 SECVKSI 518 E + Sbjct: 81 YEAATLL 87 >3TZ6-A nrPDB Length = 344 Score = 29.6 bits (65), Expect = 3.7, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 6/59 (10%) Query: 394 LHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARS-MEGVQAFIWQEFASALEVIP 451 LHD ++R +V ++G G + L+++AR+ + G + ++ ALE P Sbjct: 141 LHDEARLVRLVVSSYQAVSGSGLAGVA---ELAEQARAVIGGAEQLVYDG--GALEFPP 194 >1XG3-A nrPDB Length = 295 Score = 29.6 bits (65), Expect = 3.7, Method: Composition-based stats. Identities = 33/188 (17%), Positives = 68/188 (36%), Gaps = 33/188 (17%) Query: 305 LSKLNIMVVKDIEREEIEFLSKGLGCKPIADIE-LFTEDRLGSADLVEEIDSDGSKIVRV 363 L L I + D+ +I ++ + D + F A V+ + G+ + + Sbjct: 55 LPDLGISTLDDVL-TDIRRITDVCSLPLLVDADIGFGSSAFNVARTVKSMIKAGAAGLHI 113 Query: 364 T---GIRNNNARPTVSVVIRGANNMIIDETERSLH-------------DALCV--IRCLV 405 G + + RP ++V + ++D ++ DAL V + + Sbjct: 114 EDQVGAKRSGHRPNKAIV---SKEEMVDRIRAAVDAKTDPDFVIMARTDALAVEGLDAAI 170 Query: 406 KERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKV 465 + GA E+ +++ A ++++FA A++V G + Sbjct: 171 ERAQAYVEAGA-EMLFPEAITELA---------MYRQFADAVQVPILANITEFGATPLFT 220 Query: 466 VTELRSKH 473 ELRS H Sbjct: 221 TDELRSAH 228 >5CB0-A nrPDB Length = 316 Score = 29.2 bits (64), Expect = 4.0, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 35/89 (39%), Gaps = 4/89 (4%) Query: 256 DYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKD 315 D + ++ + + ++ N+ ++K + + + DLA H + I+V+ Sbjct: 213 DPSVYNDAIRGQHLLAMKALRQKFGINENMTHVEKGLPEEVIPDLAEHL--QAGIVVLGT 270 Query: 316 IEREEIEFLSKGLGCKPIADIELFTEDRL 344 + R I + LG I+ D L Sbjct: 271 VGRTGIS--AAFLGNTAEQVIDHLRCDLL 297 >2IOU-G nrPDB Length = 535 Score = 29.2 bits (64), Expect = 4.2, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 45/132 (34%), Gaps = 18/132 (13%) Query: 295 DAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEID 354 A +A L + V+ ++ + G I ++ + L + +V Sbjct: 113 QAQASIADSTLQGAGGVRVERGANVTVQRSTIVDGGLHIGTLQPLQPEDLPPSRVV---- 168 Query: 355 SDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETE---------RSLHDALCVIRCLV 405 + VT + + A VSV GAN + +D ++ A+ ++ Sbjct: 169 LGDTS---VTAVPASGAPAAVSVF--GANELTVDGGHITGGRAAGVAAMDGAIVHLQRAT 223 Query: 406 KERGLIAGGGAP 417 RG GGA Sbjct: 224 IRRGDAPAGGAV 235 >5Z9A-A nrPDB Length = 363 Score = 29.2 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 24/65 (36%), Gaps = 3/65 (4%) Query: 465 VVTELRSKHENGELNDGISVRR-SGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDD 523 +V L K + G S+ + + P + + T +E + +I+ +D Sbjct: 285 IVAHLALKPTSSITTPGRSIDTAGEPVDMITKGRHDPCVGIRA--TPIAEAMMAIVLLDQ 342 Query: 524 IAFSR 528 + R Sbjct: 343 LLRQR 347 >2VHI-A nrPDB Length = 405 Score = 28.8 bits (63), Expect = 5.4, Method: Composition-based stats. Identities = 8/43 (18%), Positives = 21/43 (48%) Query: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQK 290 +N+I++ ++K + + + K +A CN++ Q+ Sbjct: 78 IQNSIVIPTTAPIEKQREAIWNKVKTMIKAAAEAGCNIVCTQE 120 >4PLW-A nrPDB Length = 326 Score = 28.5 bits (62), Expect = 8.5, Method: Composition-based stats. Identities = 39/247 (15%), Positives = 74/247 (29%), Gaps = 22/247 (8%) Query: 196 LVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTE---NNI 252 + +K G + ++++G+ + S P KI D I Sbjct: 23 IAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGI 82 Query: 253 IVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMV 312 D +L + ++ + IKK N + I+ D+ ++ L K Sbjct: 83 PRKPGMSRDDLLSVNAKIMKDVAENIKKYCPNAFV----IVVTNPLDVMVYVLHKY---- 134 Query: 313 VKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSA-DLVEEIDSDG--SKIVRVT-GIRN 368 + G + F ++L + + V+ + G +V +T Sbjct: 135 ----SGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTV 190 Query: 369 NNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERG--LIAGGGAPEIEISRRLS 426 T + IDE +A I L+K A E+ S L Sbjct: 191 GGIPLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAES-YLK 249 Query: 427 KEARSME 433 + R + Sbjct: 250 DKKRILP 256 >1Q1R-A nrPDB Length = 431 Score = 28.1 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 12/32 (37%), Positives = 20/32 (62%), Gaps = 1/32 (3%) Query: 392 RSLHDALCVIRCLVKERGLIA-GGGAPEIEIS 422 R+L DA C+ R L+ + L+ GGG +E++ Sbjct: 134 RTLEDAECIRRQLIADNRLVVIGGGYIGLEVA 165 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.138 0.338 Lambda K H 0.267 0.0422 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,172,483 Number of Sequences: 36641 Number of extensions: 641726 Number of successful extensions: 2650 Number of sequences better than 10.0: 63 Number of HSP's better than 10.0 without gapping: 79 Number of HSP's successfully gapped in prelim test: 41 Number of HSP's that attempted gapping in prelim test: 2266 Number of HSP's gapped (non-prelim): 135 length of query: 528 length of database: 10,336,785 effective HSP length: 102 effective length of query: 426 effective length of database: 6,599,403 effective search space: 2811345678 effective search space used: 2811345678 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.4 bits)