BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P39077 (534 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5GW5-g nrPDB 1090 0.0 4V8R-AG nrPDB 766 0.0 4B2T-G nrPDB 671 0.0 1A6D-B nrPDB 380 e-106 1Q3S-A nrPDB 379 e-105 3J1C-A nrPDB 365 e-101 4XCI-A nrPDB 363 e-101 3RUW-A nrPDB 354 4e-98 1A6E-A nrPDB 354 6e-98 3J1E-A nrPDB 344 6e-95 3IYF-A nrPDB 342 3e-94 4XCG-B nrPDB 339 2e-93 3AQ1-B nrPDB 335 3e-92 4B2T-H nrPDB 296 2e-80 5UYZ-A nrPDB 287 7e-78 4B2T-D nrPDB 286 1e-77 5GW4-h nrPDB 275 3e-74 4V8R-AE nrPDB 263 1e-70 4B2T-A nrPDB 254 4e-68 4V94-A nrPDB 244 1e-64 1GN1-A nrPDB 241 6e-64 4B2T-Z nrPDB 238 6e-63 5GW4-d nrPDB 230 1e-60 4B2T-B nrPDB 215 4e-56 4V8R-AB nrPDB 211 9e-55 5GW5-z nrPDB 202 3e-52 5GW5-q nrPDB 186 2e-47 4B2T-Q nrPDB 180 1e-45 5X9V-A nrPDB 169 3e-42 1E0R-B nrPDB 122 3e-28 1ASS-A nrPDB 98 8e-21 1IOK-A nrPDB 59 7e-09 4AAR-A nrPDB 57 2e-08 4PJ1-A nrPDB 52 8e-07 4V4O-A nrPDB 52 8e-07 5DA8-A nrPDB 42 6e-04 1SJP-A nrPDB 41 0.001 5CDI-A nrPDB 35 0.056 5J3E-A nrPDB 31 1.2 1C9Y-A nrPDB 30 3.5 1V7N-V nrPDB 29 6.6 4DL8-A nrPDB 28 7.6 >5GW5-g nrPDB Length = 534 Score = 1090 bits (2818), Expect = 0.0, Method: Compositional matrix adjust. Identities = 534/534 (100%), Positives = 534/534 (100%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND Sbjct: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 Query: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN Sbjct: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 Query: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG 300 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG Sbjct: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG 300 Query: 301 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI 360 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI Sbjct: 301 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI 360 Query: 361 GDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATE 420 GDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATE Sbjct: 361 GDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATE 420 Query: 421 MAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF 480 MAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF Sbjct: 421 MAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF 480 Query: 481 TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 534 TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE Sbjct: 481 TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 534 >4V8R-AG nrPDB Length = 590 Score = 766 bits (1977), Expect = 0.0, Method: Compositional matrix adjust. Identities = 374/374 (100%), Positives = 374/374 (100%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND Sbjct: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 Query: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN Sbjct: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 Query: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG 300 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG Sbjct: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG 300 Query: 301 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI 360 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI Sbjct: 301 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI 360 Query: 361 GDEYFSFLDNCKEP 374 GDEYFSFLDNCKEP Sbjct: 361 GDEYFSFLDNCKEP 374 Score = 330 bits (845), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 160/160 (100%), Positives = 160/160 (100%) Query: 375 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQL 434 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQL Sbjct: 431 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQL 490 Query: 435 EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDM 494 EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDM Sbjct: 491 EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDM 550 Query: 495 VSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 534 VSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE Sbjct: 551 VSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 590 >4B2T-G nrPDB Length = 545 Score = 671 bits (1730), Expect = 0.0, Method: Compositional matrix adjust. Identities = 319/531 (60%), Positives = 415/531 (78%), Gaps = 8/531 (1%) Query: 4 PVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHA 63 PV+ ++ + +R +GR+ Q NI AAK +AD+IRTCLGPK+M+KMLLDPMGG+V+TNDG+A Sbjct: 6 PVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNA 65 Query: 64 ILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQ 123 ILREI V HPAAKSM+E+SRTQDEEVGDGTT+VIILAGE+L+ A + +E+ +HP ++I Sbjct: 66 ILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLS-VAEHFLEQQMHPTVVIS 124 Query: 124 ALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVR 183 A +KAL D + +K++S PVD N M +I +SI TK + WS C +ALDAVKTV+ Sbjct: 125 AYRKALDDMISTLKKISIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTVQ 184 Query: 184 KDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRV 243 E EIDIK+Y RVEKIPGG + DS VL+GV++NKDV HP+M R+I+NPR+ Sbjct: 185 ------FEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRI 238 Query: 244 VLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSD 303 VLLD LEYKKGESQT+IEI +EED+ RILQ+EEE +Q +CE I+ ++P +VITEKG+SD Sbjct: 239 VLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISD 298 Query: 304 LAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 LAQHYL++ + +RRV+K+DNNRIAR GA IV+R E+L+E DVGT GL +++ IGDE Sbjct: 299 LAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDE 358 Query: 364 YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 423 YF+F+ CK+PKACTI+LRG SK+IL+E++RNLQDAM V RNV+L P L PGGGA+EMAV Sbjct: 359 YFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAV 418 Query: 424 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTT- 482 + L EK+K + G++QWPY+AVA A+E IPRTLIQN G IRLL+ LRAKH Q N T Sbjct: 419 AHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETW 478 Query: 483 GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQ 533 G++G+ G +VDM GIWEP +K Q+ KTA+E+A LLLR+DDIVSG +K+ Sbjct: 479 GVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKK 529 >1A6D-B nrPDB Length = 543 Score = 380 bits (977), Expect = e-106, Method: Compositional matrix adjust. Identities = 203/525 (38%), Positives = 346/525 (65%), Gaps = 9/525 (1%) Query: 4 PVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHA 63 P+ + +R +G+ A NI AA A+++ +R+ LGP+ M KML+D +G +V+TNDG Sbjct: 6 PIFILKEGTKRESGKDAMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDGVT 65 Query: 64 ILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQ 123 IL+E+DV HPAAK M+E+S+TQD VGDGTTT +I+AG +L Q A LI +N+HP +I + Sbjct: 66 ILKEMDVEHPAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQ-AQGLINQNVHPTVISE 124 Query: 124 ALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVR 183 + A +A VI ++S + + A + K+ Q S+ +K +K+ E++ +AVK+V Sbjct: 125 GYRMASEEAKRVIDEISTKIGADEKALLLKMAQTSLNSKSASVAKDKLAEISYEAVKSV- 183 Query: 184 KDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRV 243 + +G+ + D ++V K GG + D++++ G++++K+ VHP M +++ ++ Sbjct: 184 ---AELRDGKYYVDFD---NIQVVKKQGGAIDDTQLINGIIVDKEKVHPGMPDVVKDAKI 237 Query: 244 VLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSD 303 LLD PLE KK E TN+ IE + L EE ++ M ++I +V +VIT+KG+ D Sbjct: 238 ALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGIDD 297 Query: 304 LAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 +AQHYL + G +RRVKKSD +++A+ TGA+IV+ ++++ SD+GT + +V+ +G++ Sbjct: 298 MAQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVK-VGED 356 Query: 364 YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 423 Y +F+ CK PKA +I++RG ++ +++E++R++ D++ V + + + + GGGAT + Sbjct: 357 YMTFVTGCKNPKAVSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAAEI 416 Query: 424 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTG 483 + +L A+++ G QQ + ADA+E IPR L +NAG DPI +L +LRA+HA+GN T G Sbjct: 417 AFRLRSYAQKIGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEHAKGNKTYG 476 Query: 484 IDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 I+ G+I DMV G+ EP + +Q++++A E+A ++LR+DD+++ Sbjct: 477 INVFTGEIEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVIA 521 >1Q3S-A nrPDB Length = 548 Score = 379 bits (974), Expect = e-105, Method: Compositional matrix adjust. Identities = 205/526 (38%), Positives = 336/526 (63%), Gaps = 9/526 (1%) Query: 4 PVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHA 63 PVV + +R GR AQ NI AA+ +A+ +RT LGPK M KML+D +G +V+TND Sbjct: 8 PVVILPEGTQRYVGRDAQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDCAT 67 Query: 64 ILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQ 123 IL +ID+ HPAAK M+E+++TQD+E GDGTTT +++AGE+L + A L+++NIHP III+ Sbjct: 68 ILDKIDLQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRK-AEELLDQNIHPSIIIK 126 Query: 124 ALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVR 183 A A E++ +++ VD +++ + K+ SI K E + +LA++AVK V Sbjct: 127 GYALAAEKAQEILDEIAIRVDPDDEETLLKIAATSITGKNAESHKELLAKLAVEAVKQV- 185 Query: 184 KDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRV 243 + +G+ ++D ++ EK G V +S +++GV+++K+VVHP+M + +EN ++ Sbjct: 186 ---AEKKDGKYVVDLD---NIKFEKKAGEGVEESELVRGVVIDKEVVHPRMPKRVENAKI 239 Query: 244 VLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSD 303 L++ LE KK E+ I I + L+ EE+ ++ M + I +V +KG+ D Sbjct: 240 ALINEALEVKKTETDAKINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGIDD 299 Query: 304 LAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 LAQHYL K G +RRVKKSD ++A+ TGA IV V+DL D+G + + ++ G E Sbjct: 300 LAQHYLAKYGIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAG-E 358 Query: 364 YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 423 F++ CK PKA TI++RGG++ +++E++R L+DA+ V ++VM ++ P GGA E+ + Sbjct: 359 NMIFVEGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIEL 418 Query: 424 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTG 483 +++L E AKQ+ G + + ADA++ IP+TL +NAG D + +L ++ ++H G Sbjct: 419 AIRLDEYAKQVGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISEHKNRGLGIG 478 Query: 484 IDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSG 529 ID +GK DM+ GI EP +K+Q++K+A E+A ++LR+DD+++ Sbjct: 479 IDVFEGKPADMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDVIAA 524 >3J1C-A nrPDB Length = 563 Score = 365 bits (938), Expect = e-101, Method: Compositional matrix adjust. Identities = 195/535 (36%), Positives = 333/535 (62%), Gaps = 17/535 (3%) Query: 4 PVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHA 63 PV+ R +GR A +NI AA+ +A+++R+ LGPK + KML+D G + +TNDG Sbjct: 6 PVLLFKEGTSRNSGRDALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGAT 65 Query: 64 ILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQ 123 I++E+++ HPAAK ++E ++ QD EVGDGTT+ ++LAG L + A L+++NIHP III+ Sbjct: 66 IVKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFL-EKAESLVDQNIHPTIIIE 124 Query: 124 ALKKALTDALEVIKQVSKPVDVE--NDA----AMKKLIQASIGTKYVIHWSE--KMCELA 175 KKA +LE++ Q++ VDV N A A+KK++ ++ +K++ E K+ ++ Sbjct: 125 GFKKAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNKIMDIV 184 Query: 176 LDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMS 235 +DAV TV + L +G N +D+ ++++K GG + DS++++G++L+K+VVH M Sbjct: 185 IDAVTTVAEPLP---DGGYNVSLDL---IKIDKKKGGTIEDSQLIRGIVLDKEVVHAGMP 238 Query: 236 RHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLV 295 R +E ++ +LD LE +K E I I + L E + ++ M +++ ++ +V Sbjct: 239 RRVEKAKIAVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGANVV 298 Query: 296 ITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLF 355 I +KG+ D+AQH+L K G +RRVK+SD ++ + GA I++ ++D D+G L Sbjct: 299 ICQKGIDDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGY-AELV 357 Query: 356 KVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPG 415 + +G++ F++ K PKA I+LRG + L+E +R++ DA+ RN+++ P + PG Sbjct: 358 EERKVGNDKMVFIEGAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILMEPYIVPG 417 Query: 416 GGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKH 475 GGA E+ +S +L E A+ + G +Q +A ADA+E IP L + AG +PI L LRA+H Sbjct: 418 GGAIELELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDLRARH 477 Query: 476 AQGNFTTGIDGDKGKIV-DMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSG 529 A+G G+D GKI+ D+ S + EP + +Q +K+A E+A ++++DD+++ Sbjct: 478 AKGLTNCGVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDLIAA 532 >4XCI-A nrPDB Length = 559 Score = 363 bits (933), Expect = e-101, Method: Compositional matrix adjust. Identities = 198/537 (36%), Positives = 333/537 (62%), Gaps = 17/537 (3%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 M APV+ + RTTGR A +NI AAK +A+++R+ LGPK + KML+D G + +TND Sbjct: 1 MAAPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITND 60 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G I++++++ HPAAK ++E ++ QD EVGDGTT+ ++LAG +L + A L+++NIHP I Sbjct: 61 GATIVKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALL-EKAESLLDQNIHPTI 119 Query: 121 IIQALKKALTDALEVIKQVSKPVDVEN------DAAMKKLIQASIGTKYVIHWSE--KMC 172 II+ KKA ALE++ Q+ +D+++ ++K+ ++ +K++ +E K+ Sbjct: 120 IIEGYKKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKII 179 Query: 173 ELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHP 232 ++ +DA+ V + L G N +D+ ++++K GG + DS ++KG++L+K+VVHP Sbjct: 180 DMVIDAIVNVAEPLPN---GGYNVSLDL---IKIDKKKGGSIEDSVLVKGLVLDKEVVHP 233 Query: 233 KMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRP 292 M R + ++ +LD LE +K E I I E L E + ++ M +++ ++ Sbjct: 234 GMPRRVTKAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGA 293 Query: 293 TLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNC 352 +VI +KG+ D+AQH+L K G +RRVK+SD ++ + GA I++ ++D D+G Sbjct: 294 NVVICQKGIDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGY-A 352 Query: 353 GLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSL 412 L + +G++ F++ K KA I+LRG + L+E +R++ DA+ RN++L P + Sbjct: 353 ELVEERRVGNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVI 412 Query: 413 SPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR 472 PGGGA E+ +++KL E A+ + G +Q +A ADA+E IP L + AG + I L LR Sbjct: 413 LPGGGAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLR 472 Query: 473 AKHAQGNFTTGIDGDKGKIVDMV-SYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 A+HA+G TG+D GKIVD V + I EP +K Q +K+A E+A +L++DD+++ Sbjct: 473 ARHAKGLSNTGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIA 529 >3RUW-A nrPDB Length = 543 Score = 354 bits (909), Expect = 4e-98, Method: Compositional matrix adjust. Identities = 192/517 (37%), Positives = 318/517 (61%), Gaps = 13/517 (2%) Query: 13 ERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAH 72 +R GR AQ NI A + +A+ +R+ LGPK M KML+D +G +V+TNDG ILRE+ V H Sbjct: 13 KRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEH 72 Query: 73 PAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDA 132 PAAK ++E+++TQ++EVGDGTTT +++AGE+L + A L+++N+HP I+++ + A A Sbjct: 73 PAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRK-AEELLDQNVHPTIVVKGYQAAAQKA 131 Query: 133 LEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEG 192 E++K ++ V ++ + K+ SI K EK+ E+ ++AV V D G+ Sbjct: 132 QELLKTIACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEGK---- 187 Query: 193 EPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEY 252 +D K +++EK G + D+ ++KGVL++K+ V +M + + + ++ LL+C +E Sbjct: 188 -----VD-KDLIKIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNCAIEI 241 Query: 253 KKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKG 312 K+ E+ I I ++ EE+ ++ M +I A ++ +KG+ DLAQHYL K Sbjct: 242 KETETDAEIRITDPAKLMEFIEQEEKMLKDMVAEIKASGANVLFCQKGIDDLAQHYLAKE 301 Query: 313 GCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCK 372 G RRVKKSD ++A+ TGA ++ + L D+G + GL + I + F++ CK Sbjct: 302 GIVAARRVKKSDMEKLAKATGANVIAAIAALSAQDLG-DAGLVEERKISGDSMIFVEECK 360 Query: 373 EPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAK 432 PKA T+++RG ++ ++ E+ R + DA+ V + + GGG+TE+ +S+KL E A+ Sbjct: 361 HPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAE 420 Query: 433 QLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTTGIDGDKGKI 491 + G +Q +A ADA+E IPRTL +NAG D I +L ++RA HA GN G++ G + Sbjct: 421 GISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGAV 480 Query: 492 VDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 DM G+ EP +K Q++++A ES +LLR+DD+++ Sbjct: 481 EDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIA 517 >1A6E-A nrPDB Length = 545 Score = 354 bits (908), Expect = 6e-98, Method: Compositional matrix adjust. Identities = 192/530 (36%), Positives = 321/530 (60%), Gaps = 17/530 (3%) Query: 2 QAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDG 61 Q P++ + +R G+ AQ +NI AAKA+AD +RT LGPK M KML+D +G ++++NDG Sbjct: 5 QVPILVLKEGTQREQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISNDG 64 Query: 62 HAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVII 121 IL+E+DV HP AK ++E+S+ QD VGDGTTT ++L+GE+L Q A L+++ +HP +I Sbjct: 65 ATILKEMDVEHPTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQ-AETLLDQGVHPTVI 123 Query: 122 IQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCEL---ALDA 178 + A+ +A ++I ++++ +DA ++K+ ++ K ++ + +L A++A Sbjct: 124 SNGYRLAVNEARKIIDEIAEK--STDDATLRKIALTALSGKNTGLSNDFLADLVVKAVNA 181 Query: 179 VKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHI 238 V VR G+T+ N ++D K GG V D++ + G++++K+ VH KM + Sbjct: 182 VAEVRD--GKTIVDTANIKVDKKN--------GGSVNDTQFISGIVIDKEKVHSKMPDVV 231 Query: 239 ENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITE 298 +N ++ L+D LE KK E + ++I L E + M E+I +V+ + Sbjct: 232 KNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVVLCQ 291 Query: 299 KGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVE 358 KG+ D+AQHYL K G +RRVKKSD ++A+ TGA IV ++DL S +G + Sbjct: 292 KGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLG-EAETVEER 350 Query: 359 MIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGA 418 IGD+ +F+ CK PKA +I++RGG+ +++E++R L DA+ V GGGA Sbjct: 351 KIGDDRMTFVMGCKNPKAVSILIRGGTDHVVSEVERALNDAIRVVAITKEDGKFLWGGGA 410 Query: 419 TEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQG 478 E ++++LA+ A + G +Q +A A A+E IPRTL +NAG DPI L +L+A +G Sbjct: 411 VEAELAMRLAKYANSVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADDEKG 470 Query: 479 NFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 + G+D D + DM + G+ +P +K ++++A+E A ++LR+DD+++ Sbjct: 471 RISVGVDLDNNGVGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIA 520 >3J1E-A nrPDB Length = 553 Score = 344 bits (882), Expect = 6e-95, Method: Compositional matrix adjust. Identities = 187/530 (35%), Positives = 321/530 (60%), Gaps = 10/530 (1%) Query: 4 PVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHA 63 PV+ + RT G++A +NI A KAV + +++ GP+ M KML+D +G + +TNDG Sbjct: 15 PVIILKEGSSRTYGKEAVRANIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITITNDGAT 74 Query: 64 ILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQ 123 IL ++D+ HPAAK ++++++ QDEE DGT T +I +GE L + A L+ K++HP III Sbjct: 75 ILDKMDLQHPAAKLLVQIAKGQDEETADGTKTAVIFSGE-LVKKAEDLLYKDVHPTIIIS 133 Query: 124 ALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVR 183 KKA AL+ I+++++ V + + ++K+ S+ +K V E + ++ + AV V Sbjct: 134 GYKKAEEVALQTIQELAQTVSINDTDLLRKIAMTSLSSKAVAGAREYIADIVVKAVTQVA 193 Query: 184 KDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRV 243 + G + +D+ +++ K GG + D++++ G++++K+VVHP M + +EN ++ Sbjct: 194 ELRGD------KWYVDLDN-IQIVKKAGGSINDTQLVYGIVVDKEVVHPGMPKRLENAKI 246 Query: 244 VLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSD 303 L+D LE +K E I I + L EE ++ ++ILA ++I +KG+ + Sbjct: 247 ALIDASLEVEKPELDAEIRINDPTQMQKFLDEEENLIKEKVDKILATGANVIICQKGIDE 306 Query: 304 LAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 +AQ YL K G +RR KKSD ++AR TG +V+ ++++ E D+G L + +G++ Sbjct: 307 VAQSYLAKKGVLAVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGY-ASLIEERKVGED 365 Query: 364 YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 423 F++ K PK+ +I++RGG + +++E +R L+DA+ +V+ GGGA E+ + Sbjct: 366 KMVFVEGAKNPKSISILIRGGLERLVDETERALRDALGTVADVIKDGRAIAGGGAVEIEI 425 Query: 424 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTT 482 + KL + A Q+ G +Q +A A+A+E + LI+NAG DPI LL +LR+ H + N Sbjct: 426 AKKLRKYAPQVGGKEQLAVEAYANALESLVSILIENAGFDPIDLLMKLRSTHENENNKWY 485 Query: 483 GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRK 532 GID G+ VDM G+ EP ++K ++K A E+A L+LR+DD+VS +K Sbjct: 486 GIDLYAGQPVDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVSAGKK 535 >3IYF-A nrPDB Length = 521 Score = 342 bits (876), Expect = 3e-94, Method: Compositional matrix adjust. Identities = 188/517 (36%), Positives = 311/517 (60%), Gaps = 35/517 (6%) Query: 13 ERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAH 72 +R GR AQ NI A + +A+ +R+ LGPK M KML+D +G +V+TNDG ILRE+ V H Sbjct: 13 KRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEH 72 Query: 73 PAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDA 132 PAAK ++E+++TQ++EVGDGTTT +++AGE+L + A L+++N+HP I+++ + A A Sbjct: 73 PAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRK-AEELLDQNVHPTIVVKGYQAAAQKA 131 Query: 133 LEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEG 192 E++K ++ V ++ + K+ SI K EK+ E+ ++AV V D G+ Sbjct: 132 QELLKTIACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEGK---- 187 Query: 193 EPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEY 252 +D K +++EK G + D+ ++KGVL++K+ V +M + + + ++ LL+C +E Sbjct: 188 -----VD-KDLIKIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNCAIE- 240 Query: 253 KKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKG 312 + E ++ M +I A ++ +KG+ DLAQHYL K Sbjct: 241 ---------------------ETASEMLKDMVAEIKASGANVLFCQKGIDDLAQHYLAKE 279 Query: 313 GCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCK 372 G RRVKKSD ++A+ TGA ++ ++DL D+G + GL + I + F++ CK Sbjct: 280 GIVAARRVKKSDMEKLAKATGANVITNIKDLSAQDLG-DAGLVEERKISGDSMIFVEECK 338 Query: 373 EPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAK 432 PKA T+++RG ++ ++ E+ R + DA+ V + + GGG+TE+ +S+KL E A+ Sbjct: 339 HPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAE 398 Query: 433 QLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTTGIDGDKGKI 491 + G +Q +A ADA+E IPRTL +NAG D I +L ++RA HA GN G++ G + Sbjct: 399 GISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGAV 458 Query: 492 VDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 DM G+ EP +K Q++++A ES +LLR+DD+++ Sbjct: 459 EDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIA 495 >4XCG-B nrPDB Length = 557 Score = 339 bits (870), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 189/530 (35%), Positives = 318/530 (60%), Gaps = 10/530 (1%) Query: 4 PVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHA 63 PV+ + RT G++A +NI A KA+ + +++ GP+ M KML+D +G + +TNDG Sbjct: 17 PVIILKEGSSRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGAT 76 Query: 64 ILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQ 123 IL ++D+ HP K ++++++ QDEE DGT T +ILAGE LA+ A L+ K IHP II+ Sbjct: 77 ILDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGE-LAKKAEDLLYKEIHPTIIVS 135 Query: 124 ALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVR 183 KKA AL+ I+++++PV + + ++K+ S+G+K V E + +L + AV V Sbjct: 136 GYKKAEEIALKTIQEIAQPVTINDTDVLRKVALTSLGSKAVAGAREYLADLVVKAVAQVA 195 Query: 184 KDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRV 243 + G + +D+ V++ K GG V D++++ G++++K+VVHP M + IEN ++ Sbjct: 196 ELRGD------KWYVDLDN-VQIVKKHGGSVNDTQLVYGIVVDKEVVHPGMPKRIENAKI 248 Query: 244 VLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSD 303 LLD LE +K E I I ++ L+ EE ++ ++I A +VI +KG+ + Sbjct: 249 ALLDASLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIAATGANVVICQKGIDE 308 Query: 304 LAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 +AQHYL K G +RR KKSD ++AR TG +++ +++L D+G L + +G++ Sbjct: 309 VAQHYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGY-AALVEERKVGED 367 Query: 364 YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 423 F++ K PK+ +I++RGG + +++E +R L+DA+ +V+ GGGA E+ + Sbjct: 368 KMVFVEGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAVEIEI 427 Query: 424 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTT 482 + +L + A Q+ G +Q +A A+A+E + L +NAG DPI L QLR+ H + N Sbjct: 428 AKRLRKYAPQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLHENETNKWY 487 Query: 483 GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRK 532 G++ G DM G+ EP ++K +VK A E+ L+LR+DDIV+ +K Sbjct: 488 GLNLFTGNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGKK 537 >3AQ1-B nrPDB Length = 500 Score = 335 bits (858), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 172/482 (35%), Positives = 303/482 (62%), Gaps = 8/482 (1%) Query: 47 MLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQ 106 ML+D MG +V+TNDG IL+E+D+ HPAAK ++E+S+TQD EVGDGTTT +L+GE+L++ Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 107 CAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIH 166 A LI K +H II + + A E+++ ++ + +++AA+ K+ +I K Sbjct: 61 -AEELIMKGVHSTIISEGYRHAAEKCREILETITIAISPDDEAALIKIAGTAITGKGAEA 119 Query: 167 WSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLN 226 + EK+ L + AV+++ + E E ++++ +++EK GG + DS ++ G++++ Sbjct: 120 YKEKLSALTVKAVRSIVE------EEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVID 173 Query: 227 KDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQ 286 K+ HP M +EN +++LL CP+E++K E + I+I L EE+ ++ M E+ Sbjct: 174 KERSHPNMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEK 233 Query: 287 ILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKES 346 ++A +V +KG+ D+AQ+Y+ K G +RRVKKSD R+++VTGATI+ ++ + Sbjct: 234 VIASGANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTE 293 Query: 347 DVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNV 406 DVGT GL + + + +++ C+ KA T++L GG++ +++ +D L DA+ V V Sbjct: 294 DVGT-AGLVEEKEVRGGKMTYVTGCQNSKAVTVLLHGGTEHVVDSLDHALNDALHVVGVV 352 Query: 407 MLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIR 466 + + GGG++E+ +S++L+E A L+G +Q A+A+E IP L +NAG DPI Sbjct: 353 IEDGKVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPID 412 Query: 467 LLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 526 ++ +LR++H +GN G++ G++VDM + EP IK Q++ A+E+ ++LR+DD+ Sbjct: 413 IMVELRSQHEKGNKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAMEATVMILRIDDV 472 Query: 527 VS 528 V+ Sbjct: 473 VA 474 >4B2T-H nrPDB Length = 543 Score = 296 bits (757), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 173/538 (32%), Positives = 289/538 (53%), Gaps = 22/538 (4%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 M PV+ + + + G +SNI+A + +A+ +RT LGP+ M K+++D G ++ND Sbjct: 2 MPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISND 61 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G IL+ +DV HPAAK++++++++QD EVGDGTT+V +LA E L Q PY +E+ +HP I Sbjct: 62 GATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPY-VEEGLHPQI 120 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQ----ASIGTKYVIHWSEKMCELAL 176 II+A + A A+ IK+++ V E+ +KL++ ++ +K + ++ + Sbjct: 121 IIRAFRTATQLAVNKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVV 180 Query: 177 DAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMS- 235 DAV + DL Q + + ++K+ GG + +S+++ GV K + Sbjct: 181 DAVMML-DDLLQL------------KMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEM 227 Query: 236 --RHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPT 293 + NP + LL+ LE K + I + ED+ I+ E + E+I Sbjct: 228 QPKKYHNPMIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAK 287 Query: 294 LVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCG 353 +V+++ + D+A Y RV + D R G +I V L SDV C Sbjct: 288 VVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNAL-SSDVLGRCQ 346 Query: 354 LFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLS 413 +F+ IG E ++F C + K CTI+LRGG++ + E +R+L DA+ + R + + S+ Sbjct: 347 VFEETQIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVV 406 Query: 414 PGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRA 473 GGGA EM +S L + ++ + G QQ A A A+E IPR L NAG D +L++LRA Sbjct: 407 AGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRA 466 Query: 474 KHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVR 531 +HAQG G+D + I D +WEP +++ ++ A E+ACL++ VD+ + R Sbjct: 467 RHAQGGMWYGVDINTEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPR 524 >5UYZ-A nrPDB Length = 541 Score = 287 bits (735), Expect = 7e-78, Method: Compositional matrix adjust. Identities = 175/524 (33%), Positives = 304/524 (58%), Gaps = 24/524 (4%) Query: 12 QERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVA 71 + R G +A S+I AAKAVA+ +RT LGP + KM++D G + +TNDG IL +DV Sbjct: 25 KSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVD 84 Query: 72 HPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTD 131 H AK M+ELS++QD+E+GDGTT V++LAG +L + A L+++ IHP+ I ++A Sbjct: 85 HQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEE-AEQLLDRGIHPIRIADGYEQAARV 143 Query: 132 ALEVIKQVSKP--VDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTV----RKD 185 A+E + ++S VD+++ + + + ++G+K V +M E+A++AV TV R+D Sbjct: 144 AIERLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRD 203 Query: 186 LGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVL 245 + +FE+ ++VE GG + D++++KGV+++KD HP+M + +E+ ++ + Sbjct: 204 V--------DFEL-----IKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 Query: 246 LDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLA 305 L CP E K +++ +++ ED+ + + E+E+ + M +QI L I + G D A Sbjct: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 Query: 306 QHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIG--DE 363 H LL+ +R V + IA TG IV R +L +G GL + G + Sbjct: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGF-AGLVQEISFGTTKD 369 Query: 364 YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 423 ++ CK +A TI +RGG+K I+ E R+L DA+ V RN++ + GGGA E++ Sbjct: 370 KMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISC 429 Query: 424 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTT 482 ++ ++++A + ++Q+ +A ADA+E IP L +N+G +PI+ ++++RA+ + N Sbjct: 430 ALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPAL 489 Query: 483 GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 526 GID DM + E + K+Q + A + ++L++DDI Sbjct: 490 GIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 >4B2T-D nrPDB Length = 542 Score = 286 bits (732), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 172/526 (32%), Positives = 303/526 (57%), Gaps = 16/526 (3%) Query: 9 NASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREI 68 +A Q+R Q + SNI+AAKAVAD IRT LGPK M KM+ D G + +TNDG IL+++ Sbjct: 25 SAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQM 84 Query: 69 DVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKA 128 V HPAA+ ++ELS+ QD E GDGTT+V+I+AG +L C L++K IHP II ++ +KA Sbjct: 85 QVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTK-LLQKGIHPTIISESFQKA 143 Query: 129 LTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQ 188 L +E++ +S+PV++ + + S+ +K V +S + +++DAV V Sbjct: 144 LEKGIEILTDMSRPVELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKV------ 197 Query: 189 TVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDC 248 ++ +D+ R +++ K GG + D +++G++L + V + ++R +E ++ L+ Sbjct: 198 -IDPATATSVDL-RDIKIVKKLGGTIDDCELVEGLVLTQKVANSGITR-VEKAKIGLIQF 254 Query: 249 PLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGV-----SD 303 L K + I + +R+L+ E + + +QI +++ +K + SD Sbjct: 255 CLSAPKTDMDNQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSD 314 Query: 304 LAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 LA H+L K V++ +++ D I + G V V+ +G+ +V + G Sbjct: 315 LALHFLNKMKIMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSG 374 Query: 364 YFSFLDNCKEP-KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMA 422 + C P K TI++RG +K ++ E +R++ DA+ V R ++ +L GGGA E+ Sbjct: 375 KLIKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIE 434 Query: 423 VSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTT 482 ++++L E ++ L G++ + +A ADAME IP TL +NAG +PI +++LR +HAQG TT Sbjct: 435 LALRLTEYSRTLSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTT 494 Query: 483 GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 GI+ KG I +++ + +P ++ ++ A E+ +L++DD+V+ Sbjct: 495 GINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVN 540 >5GW4-h nrPDB Length = 550 Score = 275 bits (704), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 165/538 (30%), Positives = 295/538 (54%), Gaps = 29/538 (5%) Query: 2 QAP-VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Q P +V + + + G+ ISNI A AV + ++ LGP +++ ++ND Sbjct: 6 QTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISND 65 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G IL+ +DV HPAAK+++++SR QD EVGDGTT+V ILAGE++ + P+L E+ I + Sbjct: 66 GATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFL-EEGISSHL 124 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAA---MKKLIQASIGTKYVIHWSEKMCELALD 177 I++ +KA++ A+E I +++ + E + +++ + ++ +K + + ++ ++ +D Sbjct: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 Query: 178 AVKTV-RKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMS- 235 AV ++ R DL + + ++KIPGG + +S + GV K + Sbjct: 185 AVLSLDRNDLDD-------------KLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQ 231 Query: 236 --RHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPT 293 + NP+++ L+ LE K + + +E ED+ I+ E QL+ E++ V T Sbjct: 232 QPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAE---WQLIFEKLRQVEET 288 Query: 294 ---LVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGT 350 +V+++ + DLA + RV D NR+ + G +I + D+K +GT Sbjct: 289 GANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGT 348 Query: 351 NCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSP 410 C LF+ IG E ++ C + K CT++LRGG++ ++ E++R+L DA+ + + + + Sbjct: 349 -CALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNK 407 Query: 411 SLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQ 470 + GGGATEM VS L + +K + G QQ A A A+E IPR L +NAG D I +L++ Sbjct: 408 LIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNK 467 Query: 471 LRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 LR H++G G+ + I D + +WEP ++K ++ +A E+ L+L VD+ ++ Sbjct: 468 LRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 >4V8R-AE nrPDB Length = 562 Score = 263 bits (672), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 168/548 (30%), Positives = 306/548 (55%), Gaps = 33/548 (6%) Query: 1 MQAPVVFM--NASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLT 58 M P + + +++R G +A+ S+I AA++VA +I+T LGP+ + K+L+ P G + +T Sbjct: 25 MGRPFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITIT 84 Query: 59 NDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHP 118 NDG IL ++++ + AK +++LS++QD+E+GDGTT V++LA +L Q A LI+K IHP Sbjct: 85 NDGATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQ-ALELIQKGIHP 143 Query: 119 VIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLI----QASIGTKYVIHWSEKMCEL 174 + I +A A+ +++ + ND + + + S+G+K V ++ E+ Sbjct: 144 IKIANGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEM 203 Query: 175 ALDAVKTV----RKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV 230 A++AV V RKD+ +F++ IK RV GG + DS+++ GV+L+KD Sbjct: 204 AVEAVINVMDKDRKDV--------DFDL-IKMQGRV----GGSISDSKLINGVILDKDFS 250 Query: 231 HPKMSRHI------ENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMC 284 HP+M + + + ++ +L CP E K +++ ++I E++ ++ E+++ + M Sbjct: 251 HPQMPKCVLPKEGSDGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMI 310 Query: 285 EQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLK 344 + + +VI + G D A H LL+ +R V + IA T IV R +DL Sbjct: 311 DDVKKAGADVVICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLS 370 Query: 345 ESDVGTNCGLFKVEM-IGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVA 403 + +GT +++ E + ++ KE K T +RG +K I++E +R L D++ V Sbjct: 371 KDKLGTCSRIYEQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVV 430 Query: 404 RNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGD 463 RN++ + GGGA E+ +S+ ++E+A + GI Q+ ++ A A++ IP TL +N+G D Sbjct: 431 RNLVKDSRVVYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLD 490 Query: 464 PIRLLSQLRAKHAQGNFTT-GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLR 522 PI LS L++K + + G+D DM + +P + K+Q + A + ++L+ Sbjct: 491 PIGTLSTLKSKQLKEKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILK 550 Query: 523 VDD-IVSG 529 +D+ I+SG Sbjct: 551 IDNVIISG 558 >4B2T-A nrPDB Length = 556 Score = 254 bits (650), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 166/550 (30%), Positives = 294/550 (53%), Gaps = 42/550 (7%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 M+ P+ +R+TG + N+ AA ++A+++++ LGP + KML+D +G + +TND Sbjct: 1 MEGPLSVFG---DRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITND 57 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G IL+ ++V HPAAK + EL+ QD+EVGDGTT+V+I+A E+L + A L+++ IHP Sbjct: 58 GATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELL-KNADELVKQKIHPTS 116 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKK-LIQA---SIGTKYVIHWSEKMCELAL 176 +I + A +A ++ +S+ + + D + LI A S+ +K + + L + Sbjct: 117 VISGYRLACKEA---VRYISENLIINTDELGRDCLINAAKTSMSSKVIGINGDFFANLVV 173 Query: 177 DAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSR 236 DAV ++ + G+P + ++ + V K G ++S ++ G LN V M + Sbjct: 174 DAVLAIKY---TDIRGQPRYPVN---SINVLKAHGRSQMESMLINGYALNCVVGSQGMPK 227 Query: 237 HIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVI 296 I N ++ LD L+ K + + I E ++I Q E + + ++ILA +++ Sbjct: 228 RIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVIL 287 Query: 297 TEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFK 356 T G+ D+ Y ++ G +RRV K D RIA+ +GAT+++ + +L+ + F+ Sbjct: 288 TTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATVLSTLANLEGEET------FE 341 Query: 357 VEMIG-----------DEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARN 405 M+G D+ + N K + +++LRG + + +E++R+L DA+ V + Sbjct: 342 ASMLGQAEEVVQERICDDELILIKNTKARTSASVILRGANDFMCDEMERSLHDALCVVKR 401 Query: 406 VMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPI 465 V+ S S+ PGGGA E A+S+ L A + +Q A ++ IP TL NA D Sbjct: 402 VLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDST 461 Query: 466 RLLSQLRAKHAQGNFT--------TGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESA 517 L+++LRA H + G+D GK D G++EP ++K +S+K A E+A Sbjct: 462 DLVAKLRAFHNEAQVNPERKNLKWIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAA 521 Query: 518 CLLLRVDDIV 527 +LR+DD++ Sbjct: 522 ITILRIDDLI 531 >4V94-A nrPDB Length = 559 Score = 244 bits (622), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 165/536 (30%), Positives = 281/536 (52%), Gaps = 27/536 (5%) Query: 13 ERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAH 72 E+ +G + N+ A AVA+V+++ LGP + KML+D +G +TNDG IL +DV H Sbjct: 18 EKISGDDIRNQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDVQH 77 Query: 73 PAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDA 132 PA K ++EL++ QD E+GDGTT+V+I+A E+L + A L++ IHP II + AL +A Sbjct: 78 PAGKILVELAQQQDREIGDGTTSVVIIASELLKR-ANELVKNKIHPTTIITGFRVALREA 136 Query: 133 LEVIKQV-SKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVE 191 + I +V S VD + + + S+ +K + S+ + +DA+ V+ Q + Sbjct: 137 IRFINEVLSTSVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKT---QNSK 193 Query: 192 GEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIE--NPRVVLLDCP 249 GE + + + V V K G +S ++ G LN V M + I N ++ LD Sbjct: 194 GEIKYPV---KAVNVLKAHGKSATESLLVPGYALNCTVASQAMPKRIAGGNVKIACLDLN 250 Query: 250 LEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYL 309 L+ + I I+ E +I + E V ++I+ +V+T KG+ DL Sbjct: 251 LQKARMAMGVQINIDDPEQLEQIRKREAGIVLERVKKIIDAGAQVVLTTKGIDDLCLKEF 310 Query: 310 LKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFS--- 366 ++ +RR KK D RIAR TGAT+V+ + +L+ + + L + + FS Sbjct: 311 VEAKIMGVRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQAKFSDDE 370 Query: 367 --FLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVS 424 + + + +I+LRG + L+E++R+L D+++V + + S ++ PGGG E A++ Sbjct: 371 CILIKGTSKHSSSSIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVPGGGCVEAALN 430 Query: 425 VKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF---- 480 + L A + +Q A A+ IP+TL NA D L+++LR+ HA Sbjct: 431 IYLDNFATTVGSREQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAKPE 490 Query: 481 --------TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 G+D +GKIVD + G+ EP + K +S+K+A+E+ +LR+D +++ Sbjct: 491 DVKRRSYRNYGLDLIRGKIVDEIHAGVLEPTISKVKSLKSALEACVAILRIDTMIT 546 >1GN1-A nrPDB Length = 178 Score = 241 bits (615), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 107/170 (62%), Positives = 142/170 (83%) Query: 216 DSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQI 275 DS VL+GV++NKDV HP+M R+I+NPR+VLLD LEYKKGESQT+IEI +EED+ RILQ+ Sbjct: 3 DSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQM 62 Query: 276 EEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGAT 335 EEE + +CE I+ ++P +VITEKG+SDLAQHYL++ + +RRV+K+DNNRIAR GA Sbjct: 63 EEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGAR 122 Query: 336 IVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGS 385 IV+R E+L+E DVGT GL +++ IGDEYF+F+ +CK+PKACTI+LRG S Sbjct: 123 IVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGAS 172 >4B2T-Z nrPDB Length = 531 Score = 238 bits (606), Expect = 6e-63, Method: Compositional matrix adjust. Identities = 151/536 (28%), Positives = 286/536 (53%), Gaps = 26/536 (4%) Query: 3 APVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGH 62 A V +N E + A NI+AA+ + DV+RT LGPK +KML+ G + LT DG+ Sbjct: 2 AAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGN 61 Query: 63 AILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIII 122 +L E+ + HP A + +++ QD+ GDGTT+ +++ GE+L Q Y I + +HP II Sbjct: 62 VLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLY-ISEGLHPRIIT 120 Query: 123 QALKKALTDALEVIKQV--SKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 + + A AL+ ++QV SK +D E + + + S+ TK ++ + E +D++ Sbjct: 121 EGFEAAKEKALQFLEQVKVSKEMDRET---LIDVARTSLRTKVHAELADVLTEAVVDSIL 177 Query: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 ++K + EP ID+ V + ++ D+ +++G++L+ HP M + +E+ Sbjct: 178 AIKK------QDEP---IDL-FMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVED 227 Query: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTL------ 294 ++ + LEY+K E + + E+ ++++ E + ++ ++I+ ++ + Sbjct: 228 AYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDK 287 Query: 295 ---VITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTN 351 VI +KG+ + L K G LRR K+ + R+ G +N ++DL +G + Sbjct: 288 GFVVINQKGIDPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLG-H 346 Query: 352 CGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPS 411 GL +G+E F+F++ C P++ T++++G +K L +I ++D + +N + Sbjct: 347 AGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGC 406 Query: 412 LSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQL 471 + PG GA E+A++ L + ++G Q QA ADA+ IP+ L QN+G D L ++ Sbjct: 407 VVPGAGAVEVAMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKV 466 Query: 472 RAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 527 +A+H++ G+D + G+ + GIW+ +K+Q + + A +L VD+I+ Sbjct: 467 QAEHSESGQLVGVDLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIM 522 >5GW4-d nrPDB Length = 528 Score = 230 bits (586), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 147/516 (28%), Positives = 279/516 (54%), Gaps = 26/516 (5%) Query: 23 SNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELS 82 +NI AA++VAD IRT LGPK M KM+ G ++++NDGH IL+++ + HP A+ ++E+S Sbjct: 23 ANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVS 82 Query: 83 RTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKP 142 QD E GDGTT+V+IL G +L A L+ K IHP II + + A +++++ ++ Sbjct: 83 AAQDSEAGDGTTSVVILTGALLG-AAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHK 141 Query: 143 VDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKR 202 V + + + + S+ +K V +S + LA+D+V L + E N +++ Sbjct: 142 VSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSV------LKISDENSKNVDLN--- 192 Query: 203 YVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMS-RHIENPRVVLLDCPLEYKKGESQTNI 261 +R+ K GG + D+ ++ GV+L + + E ++ L+ + K +++ NI Sbjct: 193 DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNI 252 Query: 262 EIEKEEDWNRILQIEEEQVQLMCEQ---------ILAVRPTLVITEKGVSDLAQHYLLKG 312 + ++IL+ EE+ L+ +L ++ + I V+DLA H+L K Sbjct: 253 IVNDYRQMDKILK--EERAYLLNICKKIKKAKCNVLLIQKS--ILRDAVNDLALHFLSKL 308 Query: 313 GCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYF--SFLDN 370 V++ +++ + +++ G + +E E +G+ + +++ G + + + N Sbjct: 309 NIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRN 368 Query: 371 CKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEK 430 ++++RG + I++E +R+L DA+ V R ++ L GGGA E+ +S +L+++ Sbjct: 369 NNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKE 428 Query: 431 AKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGK 490 A+ +EG+Q + +Q A A+E IP TL +NAG + I+++++LR+KH G GI + Sbjct: 429 ARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSG 488 Query: 491 IVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 526 + I +P ++ ++ A E +LR+DDI Sbjct: 489 TTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 >4B2T-B nrPDB Length = 535 Score = 215 bits (547), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 162/535 (30%), Positives = 276/535 (51%), Gaps = 30/535 (5%) Query: 3 APVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPM--GGLVLTND 60 APV A + A++S+ A A+ D++++ LGPK M K+LL L++TND Sbjct: 7 APVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTND 66 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G IL+ I V +PAAK ++++SR QD+EVGDGTT+V +LA E+L + A LI K IHP Sbjct: 67 GATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLRE-AESLIAKKIHPQT 125 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAA-----MKKLIQASIGTKYVIHWSEKMCELA 175 II ++A A + + ++ VD +D + + ++ +K + H + +LA Sbjct: 126 IIAGWREATKAARQAL--LNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLA 183 Query: 176 LDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKD--VVHPK 233 ++AV ++ G N E + V K GG + DS + +G LL+K V PK Sbjct: 184 VEAVLRLK--------GSGNLE-----AIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPK 230 Query: 234 MSRHIENPRVVLLDCPLEYKKGE-SQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRP 292 IEN ++++ + ++ K + + + ++ I E+E+++ E+IL Sbjct: 231 ---RIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGI 287 Query: 293 TLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNC 352 I + + + + G + R+A VTG I + + + +G+ C Sbjct: 288 NCFINRQLIYNYPEQLFGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGS-C 346 Query: 353 GLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSL 412 L + MIG++ +ACTI+LRG ++ IL+E +R+L DA+ V + Sbjct: 347 KLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRT 406 Query: 413 SPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR 472 GGG +EM ++ + + A + G + ++ A A+ +P + NAG D L++QLR Sbjct: 407 VYGGGCSEMLMAHAVTQLASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLR 466 Query: 473 AKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 527 A H++G T G+D +G I DM GI E +K+Q + +A E+A ++LRVD+I+ Sbjct: 467 AAHSEGKTTAGLDMKEGTIGDMSVLGITESFQVKRQVLLSAAEAAEVILRVDNII 521 >4V8R-AB nrPDB Length = 527 Score = 211 bits (536), Expect = 9e-55, Method: Compositional matrix adjust. Identities = 152/524 (29%), Positives = 272/524 (51%), Gaps = 26/524 (4%) Query: 11 SQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGL-VLTNDGHAILREID 69 ++ER A++S A AV D++++ LGPK M K+L ++TNDG IL+ I Sbjct: 11 TEER--AENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIP 68 Query: 70 VAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKAL 129 + +PAAK ++ +S+ QD+EVGDGTT+V +L+ E+L + + + IHP II+ + A Sbjct: 69 LDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLAS 128 Query: 130 TDALEVIKQVSKPVDVENDAAMKK-----LIQASIGTKYVIHWSEKMCELALDAVKTVRK 184 AL+ + + + VD +D M + + + ++ +K + + ELA +A+ ++ Sbjct: 129 AAALDALTKAA--VDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRLK- 185 Query: 185 DLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVV 244 G N E ++++ KI GG + DS + +G +L K + + R IEN +++ Sbjct: 186 -------GSTNLE-----HIQIIKILGGKLSDSFLDEGFILAKKFGNNQPKR-IENAKIL 232 Query: 245 LLDCPLEYKKGE-SQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSD 303 + + L+ K + T +++ ++ + E E+++ +I I + + D Sbjct: 233 IANTTLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYD 292 Query: 304 LAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 + G + + R+A VTG +V+ ++ + +G C + + M+G++ Sbjct: 293 YPEQLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLG-ECDVIEEIMLGEQ 351 Query: 364 YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 423 F CK +ACTI+LRG + L+E +R+L DA++V GGG EM + Sbjct: 352 PFLKFSGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVM 411 Query: 424 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTG 483 S + +A+ ++G + +A A A+ +P L NAG D L+S+LR+ G T+G Sbjct: 412 SKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSG 471 Query: 484 IDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 527 +D + G I DM GI E +K+ V +A E+A +LLRVD+I+ Sbjct: 472 LDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNII 515 >5GW5-z nrPDB Length = 546 Score = 202 bits (514), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 149/534 (27%), Positives = 269/534 (50%), Gaps = 43/534 (8%) Query: 24 NITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSR 83 N+T+A+ + V+ T LGPK LKML+D G + LT DG +L E+ + P A + + Sbjct: 22 NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAA 81 Query: 84 TQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQ--VSK 141 QDE GDGTTTV+ L GE+L Q A I++ +HP II + A ++++ + + +SK Sbjct: 82 AQDEITGDGTTTVVCLVGELLRQ-AHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISK 140 Query: 142 PVDVEND-AAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDI 200 ++ ND + ++ ++S+ TK +E + + DAV +V N ++ + Sbjct: 141 -TNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQAD------NLDLHM 193 Query: 201 KRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTN 260 ++++ + D+ +KG++L+ HP M ++N V++L+ LEY+K E + Sbjct: 194 VEIMQMQHLSPK---DTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSG 250 Query: 261 IEIEKEEDWNRILQIEEEQVQLMCEQILAVRP----------TLVITEKGVSDLAQHYLL 310 + +++ E + V ++I+ ++ ++I +KG+ ++ Sbjct: 251 FFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFA 310 Query: 311 KGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDN 370 K LRR K+ + R+ VTG N VEDL +G + GL E IG+E F+++ Sbjct: 311 KHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFS-GLVYQETIGEEKFTYVTE 369 Query: 371 CKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSV----- 425 +PK+CTI+++G + L + ++D + NV+ ++ PG GA +A+S Sbjct: 370 NTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSA 429 Query: 426 ---KLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR-----AKHAQ 477 KL K K GI +A A+A+ IP+TL++N+G DP+ +L+ + A+ + Sbjct: 430 NMNKLGAKGKTKTGI-----EAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSD 484 Query: 478 GNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVR 531 G+D + G D GIW+ + + ++ A A LL D+++ R Sbjct: 485 ETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGR 538 >5GW5-q nrPDB Length = 568 Score = 186 bits (472), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 152/526 (28%), Positives = 267/526 (50%), Gaps = 29/526 (5%) Query: 22 ISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLEL 81 I +I A + + + T +GP K++++ +G +++TND +LRE+D+ HPA K ++ Sbjct: 29 IKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMA 88 Query: 82 SRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQ--V 139 + Q ++GDGT V+ILAGE+L + LI + V IIQ A L+ + + V Sbjct: 89 TEQQKIDMGDGTNLVMILAGELL-NVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVV 147 Query: 140 SKPVDVENDAAMKKLIQASIGTKYVIHWSEK-MCELALDAVKTVRKDLGQTVEGEPNFEI 198 + D + + K+I+ I +K + SE + EL +AV V + Q P F + Sbjct: 148 GEITDKNDKNELLKMIKPVISSKK--YGSEDILSELVSEAVSHVLP-VAQQAGEIPYFNV 204 Query: 199 DIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV-HPKMSRHIENPRVVLLDCPLEYKKGES 257 D +RV KI GG + +S V+KG++ N++ H K + +V + CPL+ E+ Sbjct: 205 D---SIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTET 261 Query: 258 QTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVL 317 + + + ++ + EE+Q+ M ++I + ++ GV +LA HYL + G VL Sbjct: 262 KGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVL 321 Query: 318 RRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKE-PKA 376 + K + R+ RV GAT + R+ ++G + +E+ GD F E + Sbjct: 322 KVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRT 381 Query: 377 CTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPS---LSPGGGATEMAVSVKLAEKAKQ 433 TI+LRG +++ L++I+R + D +A + +M PS L PG GATE+ + ++ + ++ Sbjct: 382 STIILRGATQNNLDDIERAIDDGVAAVKGLM-KPSGGKLLPGAGATEIELISRITKYGER 440 Query: 434 LEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKH--------AQGNFTTGID 485 G+ Q + A A E +PRTL + AG D +L L A H + G+D Sbjct: 441 TPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVD 500 Query: 486 ----GDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 527 D+G + D+ I++ K+ ++ A E+A +L +D I+ Sbjct: 501 IDGESDEG-VKDIREENIYDMLATKKFAINVATEAATTVLSIDQII 545 >4B2T-Q nrPDB Length = 548 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 144/515 (27%), Positives = 258/515 (50%), Gaps = 22/515 (4%) Query: 19 QAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSM 78 +A NI A K +A RT GP M KM+++ + L +TND ILRE++V HPAAK + Sbjct: 27 EAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMI 86 Query: 79 LELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQ 138 + S Q++EVGDGT V++ A L + A L+ + +I+ + A A E++ Sbjct: 87 VMASHMQEQEVGDGTNFVLVFA-GALLELAEELLRLGLSVSEVIEGYEIACKKAHEILPD 145 Query: 139 V--SKPVDVENDAAMKKLIQASIGTKYVIHWSE-KMCELALDAVKTVRKDLGQTVEGEPN 195 + ++ + + L+ S+ +K + +E + +L A ++ D G Sbjct: 146 LVCCSAKNLRDVDEVSSLLHTSVMSKQ--YGNEVFLAKLIAQACVSIFPDSGH------- 196 Query: 196 FEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKG 255 F +D +RV KI G V S VL G++ K+ S +++ ++ + CP + Sbjct: 197 FNVD---NIRVCKILGSGVHSSSVLHGMVFKKETEGDVTS--VKDAKIAVYSCPFDGMIT 251 Query: 256 ESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCS 315 E++ + I+ E+ + EE + + I +V+T V+D+A HY K Sbjct: 252 ETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVADMALHYANKYNIM 311 Query: 316 VLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPK 375 ++R K D R+ + GAT + R+ ++G +C + +GD + KE Sbjct: 312 LVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMG-HCDSVYLSEVGDTQVVVFKHEKEDG 370 Query: 376 A-CTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQL 434 A TI+LRG + +++++I+R + D + + + L PGGGATE+ ++ ++ + Sbjct: 371 AISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETC 430 Query: 435 EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGID--GDKGKIV 492 G++Q+ + A+A E IPR L +N+G ++S+L A H +GN G+D + + Sbjct: 431 PGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVK 490 Query: 493 DMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 527 DM+ G+ + + K ++K A +A +LRVD I+ Sbjct: 491 DMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQII 525 >5X9V-A nrPDB Length = 521 Score = 169 bits (428), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 138/526 (26%), Positives = 265/526 (50%), Gaps = 35/526 (6%) Query: 9 NASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREI 68 N +QE QA SN A KA+ V+ LGPK + ML+D G +V+TNDG IL + Sbjct: 5 NQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLM 64 Query: 69 DVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKA 128 D HPAA+ ++ ++R Q+ EVGDGTTT +LAG ++++ ++ K + ++ + +A Sbjct: 65 DAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQIL-KGVPVSKVLAGMNRA 123 Query: 129 LTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQ 188 L AL +I++ + V D +L+ A+ K E++ + DA + L Sbjct: 124 LNHALFLIRKNAIKVGSITD---DRLLAAA---KIAGRGDERVAAILRDAAAMLEDKL-- 175 Query: 189 TVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDC 248 +P F++ +V D+ ++ GV++NK + + S+ ++ R+++LD Sbjct: 176 ---QDPGFKLADLVLAKVGA-------DTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDD 225 Query: 249 PLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHY 308 L ++ E + E + + +I +E ++ + E L V+ L++ +G+SD+A+ + Sbjct: 226 GLYPEEVEEEALASEAGFEQYLKNQKIFQENLKKLKE--LGVK--LILLTRGISDIAEEF 281 Query: 309 LLKGGCSVLRRVKKSDNNRIARVTGATIVNR------VEDLKESDVGTNCGLFKVEMIGD 362 + V+ R+ + + R+ TGA R VE+L++ +G F + Sbjct: 282 CYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKM-LGYARTCFYDSRLD- 339 Query: 363 EYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMA 422 F+ ++ T+++ + ++++E +R +DA S L PGGGA + Sbjct: 340 --FTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSGVL-PGGGAFFLY 396 Query: 423 VSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQ-GNFT 481 +S ++ +L G++ + A ++A++ R + +NAG + + L L Q N+ Sbjct: 397 LSREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYA 456 Query: 482 TGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 527 G+D + G+ +DM++ G+ +P + Q+VK A E A LL+++ I+ Sbjct: 457 LGLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTII 502 >1E0R-B nrPDB Length = 159 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 59/153 (38%), Positives = 102/153 (66%), Gaps = 1/153 (0%) Query: 220 LKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQ 279 + G++++K+ VHP M +++ ++ LLD PLE KK E TN+ IE + L EE Sbjct: 1 MNGIIVDKEKVHPGMPDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENM 60 Query: 280 VQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNR 339 ++ M ++I +V +VIT+KG+ D+AQHYL + G +RRVKKSD +++A+ TGA+IV+ Sbjct: 61 LREMVDKIKSVGANVVITQKGIDDMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVST 120 Query: 340 VEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCK 372 ++++ SD+GT + +V+ +G++Y +F+ K Sbjct: 121 IDEISSSDLGTAERVEQVK-VGEDYMTFVTGSK 152 >1ASS-A nrPDB Length = 159 Score = 98.2 bits (243), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 54/153 (35%), Positives = 86/153 (56%), Gaps = 1/153 (0%) Query: 220 LKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQ 279 + G++++K+ VH KM ++N ++ L+D LE KK E + ++I L E Sbjct: 1 MSGIVIDKEKVHSKMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNT 60 Query: 280 VQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNR 339 + M E+I +V+ +KG+ D+AQHYL K G +RRVKKSD ++A+ TGA IV Sbjct: 61 FKQMVEKIKKSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTD 120 Query: 340 VEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCK 372 ++DL S +G + IGD+ +F+ CK Sbjct: 121 LDDLTPSVLG-EAETVEERKIGDDRMTFVMGCK 152 >1IOK-A nrPDB Length = 545 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 115/532 (21%), Positives = 226/532 (42%), Gaps = 65/532 (12%) Query: 31 VADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVA----HPAAKSMLELSRTQD 86 +AD ++ LGPK ++ G +T DG ++ +EI+++ + A+ + E++ + Sbjct: 23 LADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELSDKFENMGAQMVREVASRTN 82 Query: 87 EEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVE 146 +E GDGTTT +LA I+ + + ++P+ + + + A +E IK ++PV+ Sbjct: 83 DEAGDGTTTATVLAQAIVREGLKA-VAAGMNPMDLKRGIDVATAKVVEAIKSAARPVNDS 141 Query: 147 NDAAMKKLIQASIGTKYVIHW-SEKMCELALDAVKTVRKDLGQTVEGE--PNFEIDIKRY 203 ++ A I A+ G ++ +E M + + V TV ++ G E E + D + Y Sbjct: 142 SEVAQVGTISAN-GESFIGQQIAEAMQRVGNEGVITVEENKGMETEVEVVEGMQFD-RGY 199 Query: 204 VRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKK--------- 254 + + D + + + +L +H K ++ P V LL+ ++ +K Sbjct: 200 LSPYFVTNADKMIAELEDAYIL----LHEKKLSSLQ-PMVPLLESVIQSQKPLLIVAEDV 254 Query: 255 -GESQTNIEIEKEEDWNRILQIEE----EQVQLMCEQILAVRPTLVITEKGVSDLAQHYL 309 GE+ + + K +I ++ ++ + M + I + VI+E DL L Sbjct: 255 EGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAILTGGQVISE----DLGMK-L 309 Query: 310 LKGGCSVLRRVKK----SDNNRIARVTG--ATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 +L R KK DN I G A I RV +++ + + E + + Sbjct: 310 ENVTIDMLGRAKKVSINKDNTTIVDGAGEKAEIEARVSQIRQQ-IEETTSDYDREKLQER 368 Query: 364 YFSFLDNCKEPKACTIMLRGGSKDI-LNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMA 422 K ++ GG +I + E + DA+ R + + GGG Sbjct: 369 V------AKLAGGVAVIRVGGMTEIEVKERKDRVDDALNATR-AAVQEGIVVGGG----- 416 Query: 423 VSVKLAEKAKQLEGI------QQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA 476 V L + AK LEG+ Q + A+E R + +NAG D + ++R Sbjct: 417 --VALVQGAKVLEGLSGANSDQDAGIAIIRRALEAPMRQIAENAGVDGAVVAGKVRESS- 473 Query: 477 QGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 + G + + DM +G+ +P + + +++ A A LL+ + +++ Sbjct: 474 --DKAFGFNAQTEEYGDMFKFGVIDPAKVVRTALEDAASVAGLLITTEAMIA 523 >4AAR-A nrPDB Length = 548 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 73/137 (53%), Gaps = 5/137 (3%) Query: 10 ASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREID 69 A+++ G A++ + +AD ++ LGPK +L G +T DG ++ REI+ Sbjct: 2 AAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIE 61 Query: 70 V----AHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQAL 125 + + A+ + E++ ++ GDGTTT +LA I+ + + ++P+ + + + Sbjct: 62 LEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKA-VAAGMNPMDLKRGI 120 Query: 126 KKALTDALEVIKQVSKP 142 KA+T A+E +K +S P Sbjct: 121 DKAVTAAVEELKALSVP 137 >4PJ1-A nrPDB Length = 558 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 52/192 (27%), Positives = 92/192 (47%), Gaps = 9/192 (4%) Query: 7 FMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILR 66 F ++++ G A+ + +AD + +GPK ++ G +T DG + + Sbjct: 25 FQGSAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAK 84 Query: 67 EIDV----AHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIII 122 ID+ + AK + +++ +EE GDGTTT +LA I A+ I K +PV I Sbjct: 85 SIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSI-AKEGFEKISKGANPVEIR 143 Query: 123 QALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIH-WSEKMCELALDAVKT 181 + + A+ + +K+ SKPV + A I A+ G K + + S+ M ++ V T Sbjct: 144 RGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISAN-GDKEIGNIISDAMKKVGRKGVIT 202 Query: 182 VRKDLGQTVEGE 193 V+ G+T+ E Sbjct: 203 VKD--GKTLNDE 212 >4V4O-A nrPDB Length = 543 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 37/140 (26%), Positives = 67/140 (47%), Gaps = 3/140 (2%) Query: 389 LNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADA 448 L E +DA+ R + + PGGG T + + E K+LEG + + V A Sbjct: 387 LKEKKHRFEDALNATR-AAVEEGIVPGGGVTLLRAISAVEELIKKLEGDEATGAKIVRRA 445 Query: 449 MECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQ 508 +E R + +NAG + ++ Q+ A+ + G + G+ VDMV GI +P + + Sbjct: 446 LEEPARQIAENAGYEGSVIVQQILAETKNPRY--GFNAATGEFVDMVEAGIVDPAKVTRS 503 Query: 509 SVKTAIESACLLLRVDDIVS 528 +++ A L+L + +V+ Sbjct: 504 ALQNAASIGALILTTEAVVA 523 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 32/119 (26%), Positives = 65/119 (54%), Gaps = 5/119 (4%) Query: 30 AVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREID----VAHPAAKSMLELSRTQ 85 AVA+ ++ LGP+ +L G +T DG + +E++ + + A+ + E++ Sbjct: 21 AVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENIGAQLLKEVASKT 80 Query: 86 DEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVD 144 ++ GDGTTT +LA I+ + + +P+ + + ++KA+ A+E IK ++ PV+ Sbjct: 81 NDVAGDGTTTATVLAQAIVREGLKN-VAAGANPLALKRGIEKAVEAAVEKIKALAIPVE 138 >5DA8-A nrPDB Length = 545 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 82/175 (46%), Gaps = 13/175 (7%) Query: 31 VADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHP----AAKSMLELSRTQD 86 +A+ ++ LGP ++ G T DG + +EI++ P A+ + E++ Sbjct: 23 LANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVASKTS 82 Query: 87 EEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVE 146 + GDGTTT +LA I + + P+ + + + +A+ + + ++ +S+ + Sbjct: 83 DVAGDGTTTATVLAQAIYREGLKN-VTAGARPIDLKRGIDRAVKEVVAELRNISRSI--- 138 Query: 147 NDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIK 201 + KK I A +GT + E + EL +A+ V KD TVE E ++K Sbjct: 139 ---SGKKEI-AQVGTISANNDPE-IGELIAEAMDKVGKDGVITVEEAKGMETELK 188 >1SJP-A nrPDB Length = 504 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/115 (28%), Positives = 60/115 (52%), Gaps = 8/115 (6%) Query: 53 GGLVLTNDGHAILREIDVAHP----AAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCA 108 G +TNDG +I +EI++ P A+ + E+++ D+ GDGTTT +LA + L + Sbjct: 2 GAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLA-QALVREG 60 Query: 109 PYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQA---SIG 160 + +P+ + + ++KA+ E + + +K V+ + A I A SIG Sbjct: 61 LRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIG 115 >5CDI-A nrPDB Length = 552 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 40/170 (23%), Positives = 83/170 (48%), Gaps = 7/170 (4%) Query: 31 VADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHP----AAKSMLELSRTQD 86 +A V+ +GPK +L G + NDG I RE++++ P A + + + + Sbjct: 24 LATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPVENIGATLVRQAAARTN 83 Query: 87 EEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVE 146 + GDGTTT +L+ +A+ ++ +PV +++ ++K + + ++ ++++S V + Sbjct: 84 DTAGDGTTTATVLSAAFIAE-GMKIVSAGTNPVQLVRGMEKTVQELVKELRKMSSVVQTD 142 Query: 147 NDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNF 196 D A + A T S+ M ++ V T+ + G+T E + F Sbjct: 143 KDLANVACVSAGGNTDIGSLISDAMAKVGRTGVVTMEE--GKTAEDQLVF 190 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 35/148 (23%), Positives = 71/148 (47%), Gaps = 6/148 (4%) Query: 389 LNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKL-AEKAKQLEGIQQWPYQAVAD 447 L E ++DA+ R + + PGGG T + +S K+ K + + QQ + Sbjct: 390 LKEKKLRVEDALNATR-AAVEEGVVPGGGCTLLRLSEKVDVIKRRMTDPEQQMGADIIKR 448 Query: 448 AMECIPRTLI-QNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIK 506 A+ C P LI QNAG + +++++ + ++ G + +++ GI +P + Sbjct: 449 AL-CYPIKLIAQNAGVNGSVVMNEVMKNLDRPHY--GYNAATDSFENLMETGIIDPSKVV 505 Query: 507 QQSVKTAIESACLLLRVDDIVSGVRKQE 534 + S++ A+ A L D +V+ +++ E Sbjct: 506 RCSMENAVSVAKTFLLADVVVTELKEIE 533 >5J3E-A nrPDB Length = 225 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 22/94 (23%), Positives = 38/94 (40%), Gaps = 22/94 (23%) Query: 297 TEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNC---- 352 T+ + +L+ H+L+K +R+ + G + +EDLK T C Sbjct: 46 TKNCLKNLSSHWLMKS----------EPESRLEK--GVDVKFSIEDLKAQPKQTTCWDGV 93 Query: 353 ------GLFKVEMIGDEYFSFLDNCKEPKACTIM 380 + +G+E F + NCKEP +M Sbjct: 94 RNYQARNFLRAMKLGEEAFFYHSNCKEPGIAGLM 127 >1C9Y-A nrPDB Length = 321 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 37/152 (24%), Positives = 68/152 (44%), Gaps = 27/152 (17%) Query: 288 LAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRV-KKSDNNRIARVTGATIVNRVEDLKES 346 L V +L T + +S +A +VL RV K+SD + +A+ I+N + DL Sbjct: 85 LGVNESLTDTARVLSSMAD--------AVLARVYKQSDLDTLAKEASIPIINGLSDLYHP 136 Query: 347 DVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNV 406 ++++ D Y + ++ K T+ G +IL+ I M+ A+ Sbjct: 137 ----------IQILAD-YLTLQEHYSSLKGLTLSWIGDGNNILHSI------MMSAAKFG 179 Query: 407 MLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQ 438 M + +P G + +V+ KLAE+ + G + Sbjct: 180 MHLQAATPKGYEPDASVT-KLAEQYAKENGTK 210 >1V7N-V nrPDB Length = 163 Score = 28.9 bits (63), Expect = 6.6, Method: Composition-based stats. Identities = 28/88 (31%), Positives = 43/88 (48%), Gaps = 11/88 (12%) Query: 210 PGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN---PRVVLLDCPLEYKKGESQTNIEIEKE 266 P D RVL +L + V+H ++S+ E P VLL +++ GE +T +E K Sbjct: 2 PAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPA-VDFSLGEWKTQMEETKA 60 Query: 267 EDWNRILQIEEEQVQLMCEQILAVRPTL 294 +D IL V L+ E ++A R L Sbjct: 61 QD---ILG----AVTLLLEGVMAARGQL 81 >4DL8-A nrPDB Length = 290 Score = 28.5 bits (62), Expect = 7.6, Method: Compositional matrix adjust. Identities = 27/104 (25%), Positives = 43/104 (41%), Gaps = 2/104 (1%) Query: 64 ILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQ 123 ILR + ++++ + Q GD + + + A E+L P+ KN+ +Q Sbjct: 16 ILRSLAELQDGLNTVVDKNWRQLRRPGDWSLAITMEAAELL-DSYPWKWWKNVKAQPDLQ 74 Query: 124 ALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHW 167 +K LTD L + V EN A+ K S G HW Sbjct: 75 NVKIELTDILHFSLSGAMQVSDENSGAVHKAEAGSNGES-GKHW 117 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5GW5-g nrPDB 638 0.0 4B2T-G nrPDB 604 e-173 4XCG-B nrPDB 600 e-172 3J1E-A nrPDB 592 e-170 3J1C-A nrPDB 590 e-169 1Q3S-A nrPDB 589 e-168 1A6E-A nrPDB 583 e-167 4XCI-A nrPDB 581 e-166 1A6D-B nrPDB 579 e-166 4B2T-H nrPDB 565 e-161 3RUW-A nrPDB 553 e-158 5UYZ-A nrPDB 550 e-157 4V8R-AE nrPDB 543 e-155 5GW4-h nrPDB 536 e-152 4B2T-D nrPDB 534 e-152 3AQ1-B nrPDB 534 e-152 4B2T-A nrPDB 528 e-150 3IYF-A nrPDB 522 e-148 4V94-A nrPDB 503 e-142 5GW4-d nrPDB 494 e-140 4B2T-Z nrPDB 494 e-140 4B2T-B nrPDB 485 e-137 4V8R-AB nrPDB 477 e-135 4B2T-Q nrPDB 474 e-134 5GW5-z nrPDB 469 e-132 5GW5-q nrPDB 455 e-128 4V8R-AG nrPDB 445 e-125 5X9V-A nrPDB 406 e-113 1IOK-A nrPDB 293 1e-79 4V4O-A nrPDB 260 1e-69 4PJ1-A nrPDB 239 3e-63 4AAR-A nrPDB 233 1e-61 5DA8-A nrPDB 224 7e-59 1GN1-A nrPDB 206 2e-53 1SJP-A nrPDB 194 1e-49 1E0R-B nrPDB 177 1e-44 1ASS-A nrPDB 172 3e-43 Sequences not found previously or not previously below threshold: 5CDI-A nrPDB 174 1e-43 3LXD-A nrPDB 45 1e-04 3E0V-A nrPDB 37 0.022 3OSX-A nrPDB 35 0.089 1KID-A nrPDB 34 0.14 3BWN-A nrPDB 32 0.48 2GJN-A nrPDB 32 0.69 5NNO-A nrPDB 32 0.72 1IIR-A nrPDB 32 1.0 5LY3-A nrPDB 30 1.9 4FLV-A nrPDB 30 2.3 5H12-A nrPDB 30 2.7 1SRV-A nrPDB 30 3.1 1NKQ-A nrPDB 30 3.3 5YJJ-A nrPDB 28 7.0 3FTB-A nrPDB 28 7.6 1Q1R-A nrPDB 28 7.6 1PW5-A nrPDB 28 8.3 2AP9-A nrPDB 28 9.4 >5GW5-g nrPDB Length = 534 Score = 638 bits (1645), Expect = 0.0, Method: Composition-based stats. Identities = 534/534 (100%), Positives = 534/534 (100%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND Sbjct: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 Query: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN Sbjct: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 Query: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG 300 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG Sbjct: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG 300 Query: 301 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI 360 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI Sbjct: 301 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI 360 Query: 361 GDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATE 420 GDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATE Sbjct: 361 GDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATE 420 Query: 421 MAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF 480 MAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF Sbjct: 421 MAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF 480 Query: 481 TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 534 TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE Sbjct: 481 TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 534 >4B2T-G nrPDB Length = 545 Score = 604 bits (1557), Expect = e-173, Method: Composition-based stats. Identities = 319/532 (59%), Positives = 414/532 (77%), Gaps = 8/532 (1%) Query: 3 APVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGH 62 PV+ ++ + +R +GR+ Q NI AAK +AD+IRTCLGPK+M+KMLLDPMGG+V+TNDG+ Sbjct: 5 RPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGN 64 Query: 63 AILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIII 122 AILREI V HPAAKSM+E+SRTQDEEVGDGTT+VIILAGE+L+ A + +E+ +HP ++I Sbjct: 65 AILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLS-VAEHFLEQQMHPTVVI 123 Query: 123 QALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTV 182 A +KAL D + +K++S PVD N M +I +SI TK + WS C +ALDAVKTV Sbjct: 124 SAYRKALDDMISTLKKISIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTV 183 Query: 183 RKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPR 242 E EIDIK+Y RVEKIPGG + DS VL+GV++NKDV HP+M R+I+NPR Sbjct: 184 ------QFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPR 237 Query: 243 VVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVS 302 +VLLD LEYKKGESQT+IEI +EED+ RILQ+EEE +Q +CE I+ ++P +VITEKG+S Sbjct: 238 IVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGIS 297 Query: 303 DLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGD 362 DLAQHYL++ + +RRV+K+DNNRIAR GA IV+R E+L+E DVGT GL +++ IGD Sbjct: 298 DLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGD 357 Query: 363 EYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMA 422 EYF+F+ CK+PKACTI+LRG SK+IL+E++RNLQDAM V RNV+L P L PGGGA+EMA Sbjct: 358 EYFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMA 417 Query: 423 VSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF-T 481 V+ L EK+K + G++QWPY+AVA A+E IPRTLIQN G IRLL+ LRAKH Q N T Sbjct: 418 VAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCET 477 Query: 482 TGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQ 533 G++G+ G +VDM GIWEP +K Q+ KTA+E+A LLLR+DDIVSG +K+ Sbjct: 478 WGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKK 529 >4XCG-B nrPDB Length = 557 Score = 600 bits (1548), Expect = e-172, Method: Composition-based stats. Identities = 189/532 (35%), Positives = 317/532 (59%), Gaps = 10/532 (1%) Query: 2 QAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDG 61 PV+ + RT G++A +NI A KA+ + +++ GP+ M KML+D +G + +TNDG Sbjct: 15 GIPVIILKEGSSRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDG 74 Query: 62 HAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVII 121 IL ++D+ HP K ++++++ QDEE DGT T +ILAGE LA+ A L+ K IHP II Sbjct: 75 ATILDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGE-LAKKAEDLLYKEIHPTII 133 Query: 122 IQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKT 181 + KKA AL+ I+++++PV + + ++K+ S+G+K V E + +L + AV Sbjct: 134 VSGYKKAEEIALKTIQEIAQPVTINDTDVLRKVALTSLGSKAVAGAREYLADLVVKAVAQ 193 Query: 182 VRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENP 241 V + G + +D+ V++ K GG V D++++ G++++K+VVHP M + IEN Sbjct: 194 VAELRGD------KWYVDLD-NVQIVKKHGGSVNDTQLVYGIVVDKEVVHPGMPKRIENA 246 Query: 242 RVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGV 301 ++ LLD LE +K E I I ++ L+ EE ++ ++I A +VI +KG+ Sbjct: 247 KIALLDASLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIAATGANVVICQKGI 306 Query: 302 SDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIG 361 ++AQHYL K G +RR KKSD ++AR TG +++ +++L D+G L + +G Sbjct: 307 DEVAQHYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAA-LVEERKVG 365 Query: 362 DEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEM 421 ++ F++ K PK+ +I++RGG + +++E +R L+DA+ +V+ GGGA E+ Sbjct: 366 EDKMVFVEGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAVEI 425 Query: 422 AVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQG-NF 480 ++ +L + A Q+ G +Q +A A+A+E + L +NAG DPI L QLR+ H N Sbjct: 426 EIAKRLRKYAPQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLHENETNK 485 Query: 481 TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRK 532 G++ G DM G+ EP ++K +VK A E+ L+LR+DDIV+ +K Sbjct: 486 WYGLNLFTGNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGKK 537 >3J1E-A nrPDB Length = 553 Score = 592 bits (1527), Expect = e-170, Method: Composition-based stats. Identities = 186/532 (34%), Positives = 322/532 (60%), Gaps = 10/532 (1%) Query: 2 QAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDG 61 PV+ + RT G++A +NI A KAV + +++ GP+ M KML+D +G + +TNDG Sbjct: 13 GIPVIILKEGSSRTYGKEAVRANIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITITNDG 72 Query: 62 HAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVII 121 IL ++D+ HPAAK ++++++ QDEE DGT T +I +GE++ + A L+ K++HP II Sbjct: 73 ATILDKMDLQHPAAKLLVQIAKGQDEETADGTKTAVIFSGELVKK-AEDLLYKDVHPTII 131 Query: 122 IQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKT 181 I KKA AL+ I+++++ V + + ++K+ S+ +K V E + ++ + AV Sbjct: 132 ISGYKKAEEVALQTIQELAQTVSINDTDLLRKIAMTSLSSKAVAGAREYIADIVVKAVTQ 191 Query: 182 VRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENP 241 V + G + +D+ +++ K GG + D++++ G++++K+VVHP M + +EN Sbjct: 192 VAELRGD------KWYVDLD-NIQIVKKAGGSINDTQLVYGIVVDKEVVHPGMPKRLENA 244 Query: 242 RVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGV 301 ++ L+D LE +K E I I + L EE ++ ++ILA ++I +KG+ Sbjct: 245 KIALIDASLEVEKPELDAEIRINDPTQMQKFLDEEENLIKEKVDKILATGANVIICQKGI 304 Query: 302 SDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIG 361 ++AQ YL K G +RR KKSD ++AR TG +V+ ++++ E D+G L + +G Sbjct: 305 DEVAQSYLAKKGVLAVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGY-ASLIEERKVG 363 Query: 362 DEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEM 421 ++ F++ K PK+ +I++RGG + +++E +R L+DA+ +V+ GGGA E+ Sbjct: 364 EDKMVFVEGAKNPKSISILIRGGLERLVDETERALRDALGTVADVIKDGRAIAGGGAVEI 423 Query: 422 AVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNF 480 ++ KL + A Q+ G +Q +A A+A+E + LI+NAG DPI LL +LR+ H + N Sbjct: 424 EIAKKLRKYAPQVGGKEQLAVEAYANALESLVSILIENAGFDPIDLLMKLRSTHENENNK 483 Query: 481 TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRK 532 GID G+ VDM G+ EP ++K ++K A E+A L+LR+DD+VS +K Sbjct: 484 WYGIDLYAGQPVDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVSAGKK 535 >3J1C-A nrPDB Length = 563 Score = 590 bits (1520), Expect = e-169, Method: Composition-based stats. Identities = 193/539 (35%), Positives = 333/539 (61%), Gaps = 17/539 (3%) Query: 2 QAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDG 61 PV+ R +GR A +NI AA+ +A+++R+ LGPK + KML+D G + +TNDG Sbjct: 4 GVPVLLFKEGTSRNSGRDALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDG 63 Query: 62 HAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVII 121 I++E+++ HPAAK ++E ++ QD EVGDGTT+ ++LAG L + A L+++NIHP II Sbjct: 64 ATIVKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFL-EKAESLVDQNIHPTII 122 Query: 122 IQALKKALTDALEVIKQVSKPVDVEN------DAAMKKLIQASIGTKYVIHWSE--KMCE 173 I+ KKA +LE++ Q++ VDV + A+KK++ ++ +K++ E K+ + Sbjct: 123 IEGFKKAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNKIMD 182 Query: 174 LALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPK 233 + +DAV TV + L +G N +D+ ++++K GG + DS++++G++L+K+VVH Sbjct: 183 IVIDAVTTVAEPLP---DGGYNVSLDL---IKIDKKKGGTIEDSQLIRGIVLDKEVVHAG 236 Query: 234 MSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPT 293 M R +E ++ +LD LE +K E I I + L E + ++ M +++ ++ Sbjct: 237 MPRRVEKAKIAVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGAN 296 Query: 294 LVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCG 353 +VI +KG+ D+AQH+L K G +RRVK+SD ++ + GA I++ ++D D+G Sbjct: 297 VVICQKGIDDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAE- 355 Query: 354 LFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLS 413 L + +G++ F++ K PKA I+LRG + L+E +R++ DA+ RN+++ P + Sbjct: 356 LVEERKVGNDKMVFIEGAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILMEPYIV 415 Query: 414 PGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRA 473 PGGGA E+ +S +L E A+ + G +Q +A ADA+E IP L + AG +PI L LRA Sbjct: 416 PGGGAIELELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDLRA 475 Query: 474 KHAQGNFTTGIDGDKGKIV-DMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVR 531 +HA+G G+D GKI+ D+ S + EP + +Q +K+A E+A ++++DD+++ + Sbjct: 476 RHAKGLTNCGVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDLIAASQ 534 >1Q3S-A nrPDB Length = 548 Score = 589 bits (1518), Expect = e-168, Method: Composition-based stats. Identities = 204/528 (38%), Positives = 334/528 (63%), Gaps = 9/528 (1%) Query: 2 QAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDG 61 PVV + +R GR AQ NI AA+ +A+ +RT LGPK M KML+D +G +V+TND Sbjct: 6 GQPVVILPEGTQRYVGRDAQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDC 65 Query: 62 HAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVII 121 IL +ID+ HPAAK M+E+++TQD+E GDGTTT +++AGE+L + A L+++NIHP II Sbjct: 66 ATILDKIDLQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRK-AEELLDQNIHPSII 124 Query: 122 IQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKT 181 I+ A A E++ +++ VD +++ + K+ SI K E + +LA++AVK Sbjct: 125 IKGYALAAEKAQEILDEIAIRVDPDDEETLLKIAATSITGKNAESHKELLAKLAVEAVKQ 184 Query: 182 VRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENP 241 V + +G+ ++D ++ EK G V +S +++GV+++K+VVHP+M + +EN Sbjct: 185 VAEKK----DGKYVVDLD---NIKFEKKAGEGVEESELVRGVVIDKEVVHPRMPKRVENA 237 Query: 242 RVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGV 301 ++ L++ LE KK E+ I I + L+ EE+ ++ M + I +V +KG+ Sbjct: 238 KIALINEALEVKKTETDAKINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGI 297 Query: 302 SDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIG 361 DLAQHYL K G +RRVKKSD ++A+ TGA IV V+DL D+G + + + Sbjct: 298 DDLAQHYLAKYGIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAE-VVEERKLA 356 Query: 362 DEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEM 421 E F++ CK PKA TI++RGG++ +++E++R L+DA+ V ++VM ++ P GGA E+ Sbjct: 357 GENMIFVEGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEI 416 Query: 422 AVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFT 481 ++++L E AKQ+ G + + ADA++ IP+TL +NAG D + +L ++ ++H Sbjct: 417 ELAIRLDEYAKQVGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISEHKNRGLG 476 Query: 482 TGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSG 529 GID +GK DM+ GI EP +K+Q++K+A E+A ++LR+DD+++ Sbjct: 477 IGIDVFEGKPADMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDVIAA 524 >1A6E-A nrPDB Length = 545 Score = 583 bits (1502), Expect = e-167, Method: Composition-based stats. Identities = 188/530 (35%), Positives = 317/530 (59%), Gaps = 11/530 (2%) Query: 2 QAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDG 61 Q P++ + +R G+ AQ +NI AAKA+AD +RT LGPK M KML+D +G ++++NDG Sbjct: 5 QVPILVLKEGTQREQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISNDG 64 Query: 62 HAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVII 121 IL+E+DV HP AK ++E+S+ QD VGDGTTT ++L+GE+L Q A L+++ +HP +I Sbjct: 65 ATILKEMDVEHPTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQ-AETLLDQGVHPTVI 123 Query: 122 IQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKT 181 + A+ +A ++I ++++ +DA ++K+ ++ K ++ + +L + AV Sbjct: 124 SNGYRLAVNEARKIIDEIAEK--STDDATLRKIALTALSGKNTGLSNDFLADLVVKAVNA 181 Query: 182 VRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENP 241 V + I ++V+K GG V D++ + G++++K+ VH KM ++N Sbjct: 182 VAEVRD-------GKTIVDTANIKVDKKNGGSVNDTQFISGIVIDKEKVHSKMPDVVKNA 234 Query: 242 RVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGV 301 ++ L+D LE KK E + ++I L E + M E+I +V+ +KG+ Sbjct: 235 KIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVVLCQKGI 294 Query: 302 SDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIG 361 D+AQHYL K G +RRVKKSD ++A+ TGA IV ++DL S +G + IG Sbjct: 295 DDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAET-VEERKIG 353 Query: 362 DEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEM 421 D+ +F+ CK PKA +I++RGG+ +++E++R L DA+ V GGGA E Sbjct: 354 DDRMTFVMGCKNPKAVSILIRGGTDHVVSEVERALNDAIRVVAITKEDGKFLWGGGAVEA 413 Query: 422 AVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFT 481 ++++LA+ A + G +Q +A A A+E IPRTL +NAG DPI L +L+A +G + Sbjct: 414 ELAMRLAKYANSVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADDEKGRIS 473 Query: 482 TGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVR 531 G+D D + DM + G+ +P +K ++++A+E A ++LR+DD+++ + Sbjct: 474 VGVDLDNNGVGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASKK 523 >4XCI-A nrPDB Length = 559 Score = 581 bits (1497), Expect = e-166, Method: Composition-based stats. Identities = 197/538 (36%), Positives = 333/538 (61%), Gaps = 17/538 (3%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 M APV+ + RTTGR A +NI AAK +A+++R+ LGPK + KML+D G + +TND Sbjct: 1 MAAPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITND 60 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G I++++++ HPAAK ++E ++ QD EVGDGTT+ ++LAG +L + A L+++NIHP I Sbjct: 61 GATIVKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALL-EKAESLLDQNIHPTI 119 Query: 121 IIQALKKALTDALEVIKQVSKPVDVEN------DAAMKKLIQASIGTKYVIHWSE--KMC 172 II+ KKA ALE++ Q+ +D+++ ++K+ ++ +K++ +E K+ Sbjct: 120 IIEGYKKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKII 179 Query: 173 ELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHP 232 ++ +DA+ V + L G N +D+ ++++K GG + DS ++KG++L+K+VVHP Sbjct: 180 DMVIDAIVNVAEPLP---NGGYNVSLDL---IKIDKKKGGSIEDSVLVKGLVLDKEVVHP 233 Query: 233 KMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRP 292 M R + ++ +LD LE +K E I I E L E + ++ M +++ ++ Sbjct: 234 GMPRRVTKAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGA 293 Query: 293 TLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNC 352 +VI +KG+ D+AQH+L K G +RRVK+SD ++ + GA I++ ++D D+G Sbjct: 294 NVVICQKGIDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAE 353 Query: 353 GLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSL 412 L + +G++ F++ K KA I+LRG + L+E +R++ DA+ RN++L P + Sbjct: 354 -LVEERRVGNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVI 412 Query: 413 SPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR 472 PGGGA E+ +++KL E A+ + G +Q +A ADA+E IP L + AG + I L LR Sbjct: 413 LPGGGAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLR 472 Query: 473 AKHAQGNFTTGIDGDKGKIV-DMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSG 529 A+HA+G TG+D GKIV D+ + I EP +K Q +K+A E+A +L++DD+++ Sbjct: 473 ARHAKGLSNTGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAA 530 >1A6D-B nrPDB Length = 543 Score = 579 bits (1493), Expect = e-166, Method: Composition-based stats. Identities = 202/527 (38%), Positives = 343/527 (65%), Gaps = 9/527 (1%) Query: 2 QAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDG 61 P+ + +R +G+ A NI AA A+++ +R+ LGP+ M KML+D +G +V+TNDG Sbjct: 4 GQPIFILKEGTKRESGKDAMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDG 63 Query: 62 HAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVII 121 IL+E+DV HPAAK M+E+S+TQD VGDGTTT +I+AG +L Q A LI +N+HP +I Sbjct: 64 VTILKEMDVEHPAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQ-AQGLINQNVHPTVI 122 Query: 122 IQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKT 181 + + A +A VI ++S + + A + K+ Q S+ +K +K+ E++ +AVK+ Sbjct: 123 SEGYRMASEEAKRVIDEISTKIGADEKALLLKMAQTSLNSKSASVAKDKLAEISYEAVKS 182 Query: 182 VRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENP 241 V + +G+ + D ++V K GG + D++++ G++++K+ VHP M +++ Sbjct: 183 VAELR----DGKYYVDFD---NIQVVKKQGGAIDDTQLINGIIVDKEKVHPGMPDVVKDA 235 Query: 242 RVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGV 301 ++ LLD PLE KK E TN+ IE + L EE ++ M ++I +V +VIT+KG+ Sbjct: 236 KIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGI 295 Query: 302 SDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIG 361 D+AQHYL + G +RRVKKSD +++A+ TGA+IV+ ++++ SD+GT + +G Sbjct: 296 DDMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAER-VEQVKVG 354 Query: 362 DEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEM 421 ++Y +F+ CK PKA +I++RG ++ +++E++R++ D++ V + + + + GGGAT Sbjct: 355 EDYMTFVTGCKNPKAVSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAA 414 Query: 422 AVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFT 481 ++ +L A+++ G QQ + ADA+E IPR L +NAG DPI +L +LRA+HA+GN T Sbjct: 415 EIAFRLRSYAQKIGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEHAKGNKT 474 Query: 482 TGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 GI+ G+I DMV G+ EP + +Q++++A E+A ++LR+DD+++ Sbjct: 475 YGINVFTGEIEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVIA 521 >4B2T-H nrPDB Length = 543 Score = 565 bits (1457), Expect = e-161, Method: Composition-based stats. Identities = 169/538 (31%), Positives = 284/538 (52%), Gaps = 22/538 (4%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 M PV+ + + + G +SNI+A + +A+ +RT LGP+ M K+++D G ++ND Sbjct: 2 MPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISND 61 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G IL+ +DV HPAAK++++++++QD EVGDGTT+V +LA E L Q PY +E+ +HP I Sbjct: 62 GATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPY-VEEGLHPQI 120 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKL----IQASIGTKYVIHWSEKMCELAL 176 II+A + A A+ IK+++ V E+ +KL ++ +K + ++ + Sbjct: 121 IIRAFRTATQLAVNKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVV 180 Query: 177 DAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKM-- 234 DAV + L + + ++K+ GG + +S+++ GV K + Sbjct: 181 DAVMMLDDLL-------------QLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEM 227 Query: 235 -SRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPT 293 + NP + LL+ LE K + I + ED+ I+ E + E+I Sbjct: 228 QPKKYHNPMIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAK 287 Query: 294 LVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCG 353 +V+++ + D+A Y RV + D R G +I V L +G C Sbjct: 288 VVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLG-RCQ 346 Query: 354 LFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLS 413 +F+ IG E ++F C + K CTI+LRGG++ + E +R+L DA+ + R + + S+ Sbjct: 347 VFEETQIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVV 406 Query: 414 PGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRA 473 GGGA EM +S L + ++ + G QQ A A A+E IPR L NAG D +L++LRA Sbjct: 407 AGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRA 466 Query: 474 KHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVR 531 +HAQG G+D + I D +WEP +++ ++ A E+ACL++ VD+ + R Sbjct: 467 RHAQGGMWYGVDINTEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPR 524 >3RUW-A nrPDB Length = 543 Score = 553 bits (1426), Expect = e-158, Method: Composition-based stats. Identities = 191/526 (36%), Positives = 319/526 (60%), Gaps = 13/526 (2%) Query: 7 FMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILR 66 + + +R GR AQ NI A + +A+ +R+ LGPK M KML+D +G +V+TNDG ILR Sbjct: 7 VLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILR 66 Query: 67 EIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALK 126 E+ V HPAAK ++E+++TQ++EVGDGTTT +++AGE+L + A L+++N+HP I+++ + Sbjct: 67 EMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRK-AEELLDQNVHPTIVVKGYQ 125 Query: 127 KALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDL 186 A A E++K ++ V ++ + K+ SI K EK+ E+ ++AV V D Sbjct: 126 AAAQKAQELLKTIACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDE 185 Query: 187 GQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLL 246 G+ K +++EK G + D+ ++KGVL++K+ V +M + + + ++ LL Sbjct: 186 GKV----------DKDLIKIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALL 235 Query: 247 DCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQ 306 +C +E K+ E+ I I ++ EE+ ++ M +I A ++ +KG+ DLAQ Sbjct: 236 NCAIEIKETETDAEIRITDPAKLMEFIEQEEKMLKDMVAEIKASGANVLFCQKGIDDLAQ 295 Query: 307 HYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFS 366 HYL K G RRVKKSD ++A+ TGA ++ + L D+G + GL + I + Sbjct: 296 HYLAKEGIVAARRVKKSDMEKLAKATGANVIAAIAALSAQDLG-DAGLVEERKISGDSMI 354 Query: 367 FLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVK 426 F++ CK PKA T+++RG ++ ++ E+ R + DA+ V + + GGG+TE+ +S+K Sbjct: 355 FVEECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMK 414 Query: 427 LAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTTGID 485 L E A+ + G +Q +A ADA+E IPRTL +NAG D I +L ++RA HA GN G++ Sbjct: 415 LREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLN 474 Query: 486 GDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVR 531 G + DM G+ EP +K Q++++A ES +LLR+DD+++ + Sbjct: 475 VFTGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAEK 520 >5UYZ-A nrPDB Length = 541 Score = 550 bits (1416), Expect = e-157, Method: Composition-based stats. Identities = 175/540 (32%), Positives = 305/540 (56%), Gaps = 18/540 (3%) Query: 2 QAPVVFMNAS--QERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTN 59 P + + + R G +A S+I AAKAVA+ +RT LGP + KM++D G + +TN Sbjct: 13 GRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTN 72 Query: 60 DGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPV 119 DG IL +DV H AK M+ELS++QD+E+GDGTT V++LAG +L + A L+++ IHP+ Sbjct: 73 DGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALL-EEAEQLLDRGIHPI 131 Query: 120 IIIQALKKALTDALEVIKQVSKPV--DVENDAAMKKLIQASIGTKYVIHWSEKMCELALD 177 I ++A A+E + ++S V D+++ + + + ++G+K V +M E+A++ Sbjct: 132 RIADGYEQAARVAIERLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVN 191 Query: 178 AVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRH 237 AV TV + V+ E ++VE GG + D++++KGV+++KD HP+M + Sbjct: 192 AVLTVADMERRDVDFE---------LIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKK 242 Query: 238 IENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVIT 297 +E+ ++ +L CP E K +++ +++ ED+ + + E+E+ + M +QI L I Sbjct: 243 VEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAIC 302 Query: 298 EKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKV 357 + G D A H LL+ +R V + IA TG IV R +L +G GL + Sbjct: 303 QWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGF-AGLVQE 361 Query: 358 EMIG--DEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPG 415 G + ++ CK +A TI +RGG+K I+ E R+L DA+ V RN++ + G Sbjct: 362 ISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYG 421 Query: 416 GGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKH 475 GGA E++ ++ ++++A + ++Q+ +A ADA+E IP L +N+G +PI+ ++++RA+ Sbjct: 422 GGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQ 481 Query: 476 -AQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 534 + N GID DM + E + K+Q + A + ++L++DDI +E Sbjct: 482 VKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE 541 >4V8R-AE nrPDB Length = 562 Score = 543 bits (1398), Expect = e-155, Method: Composition-based stats. Identities = 158/547 (28%), Positives = 302/547 (55%), Gaps = 24/547 (4%) Query: 1 MQAPVVFMN--ASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLT 58 M P + + +++R G +A+ S+I AA++VA +I+T LGP+ + K+L+ P G + +T Sbjct: 25 MGRPFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITIT 84 Query: 59 NDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHP 118 NDG IL ++++ + AK +++LS++QD+E+GDGTT V++LA +L Q A LI+K IHP Sbjct: 85 NDGATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQ-ALELIQKGIHP 143 Query: 119 VIIIQALKKALTDALEVIKQVSKPVDVENDAA----MKKLIQASIGTKYVIHWSEKMCEL 174 + I +A A+ +++ + ND + + + S+G+K V ++ E+ Sbjct: 144 IKIANGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEM 203 Query: 175 ALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKM 234 A++AV V + + + D+ ++++ GG + DS+++ GV+L+KD HP+M Sbjct: 204 AVEAVINVMD------KDRKDVDFDL---IKMQGRVGGSISDSKLINGVILDKDFSHPQM 254 Query: 235 SRHI------ENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQIL 288 + + + ++ +L CP E K +++ ++I E++ ++ E+++ + M + + Sbjct: 255 PKCVLPKEGSDGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVK 314 Query: 289 AVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDV 348 +VI + G D A H LL+ +R V + IA T IV R +DL + + Sbjct: 315 KAGADVVICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKL 374 Query: 349 GTNCGLFKVEM-IGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVM 407 GT +++ E + ++ KE K T +RG +K I++E +R L D++ V RN++ Sbjct: 375 GTCSRIYEQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLV 434 Query: 408 LSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRL 467 + GGGA E+ +S+ ++E+A + GI Q+ ++ A A++ IP TL +N+G DPI Sbjct: 435 KDSRVVYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGT 494 Query: 468 LSQLRAKHAQGNF-TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 526 LS L++K + G+D DM + +P + K+Q + A + ++L++D++ Sbjct: 495 LSTLKSKQLKEKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNV 554 Query: 527 VSGVRKQ 533 + + + Sbjct: 555 IISGKDE 561 >5GW4-h nrPDB Length = 550 Score = 536 bits (1380), Expect = e-152, Method: Composition-based stats. Identities = 157/535 (29%), Positives = 288/535 (53%), Gaps = 21/535 (3%) Query: 2 QAP-VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Q P +V + + + G+ ISNI A AV + ++ LGP +++ ++ND Sbjct: 6 QTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISND 65 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G IL+ +DV HPAAK+++++SR QD EVGDGTT+V ILAGE++ + A +E+ I + Sbjct: 66 GATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKE-AKPFLEEGISSHL 124 Query: 121 IIQALKKALTDALEVIKQVSKPVDVEN---DAAMKKLIQASIGTKYVIHWSEKMCELALD 177 I++ +KA++ A+E I +++ + E +++ + ++ +K + + ++ ++ +D Sbjct: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 Query: 178 AVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKM--- 234 AV ++ ++ + + ++KIPGG + +S + GV K + Sbjct: 185 AVLSLDRNDLD------------DKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQ 232 Query: 235 SRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTL 294 + NP+++ L+ LE K + + +E ED+ I+ E + + Q+ + Sbjct: 233 PKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANI 292 Query: 295 VITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGL 354 V+++ + DLA + RV D NR+ + G +I + D+K +GT C L Sbjct: 293 VLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGT-CAL 351 Query: 355 FKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSP 414 F+ IG E ++ C + K CT++LRGG++ ++ E++R+L DA+ + + + + + Sbjct: 352 FEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVA 411 Query: 415 GGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAK 474 GGGATEM VS L + +K + G QQ A A A+E IPR L +NAG D I +L++LR Sbjct: 412 GGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLA 471 Query: 475 HAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSG 529 H++G G+ + I D + +WEP ++K ++ +A E+ L+L VD+ ++ Sbjct: 472 HSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITN 526 >4B2T-D nrPDB Length = 542 Score = 534 bits (1376), Expect = e-152, Method: Composition-based stats. Identities = 171/526 (32%), Positives = 297/526 (56%), Gaps = 16/526 (3%) Query: 9 NASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREI 68 +A Q+R Q + SNI+AAKAVAD IRT LGPK M KM+ D G + +TNDG IL+++ Sbjct: 25 SAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQM 84 Query: 69 DVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKA 128 V HPAA+ ++ELS+ QD E GDGTT+V+I+AG +L C L++K IHP II ++ +KA Sbjct: 85 QVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTK-LLQKGIHPTIISESFQKA 143 Query: 129 LTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQ 188 L +E++ +S+PV++ + + S+ +K V +S + +++DAV V Sbjct: 144 LEKGIEILTDMSRPVELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATA 203 Query: 189 TVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDC 248 T R +++ K GG + D +++G++L + V + + +E ++ L+ Sbjct: 204 TSVD--------LRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGI-TRVEKAKIGLIQF 254 Query: 249 PLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGV-----SD 303 L K + I + +R+L+ E + + +QI +++ +K + SD Sbjct: 255 CLSAPKTDMDNQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSD 314 Query: 304 LAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 LA H+L K V++ +++ D I + G V V+ +G+ +V + G Sbjct: 315 LALHFLNKMKIMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSG 374 Query: 364 YFSFLDNCKEP-KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMA 422 + C P K TI++RG +K ++ E +R++ DA+ V R ++ +L GGGA E+ Sbjct: 375 KLIKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIE 434 Query: 423 VSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTT 482 ++++L E ++ L G++ + +A ADAME IP TL +NAG +PI +++LR +HAQG TT Sbjct: 435 LALRLTEYSRTLSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTT 494 Query: 483 GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 GI+ KG I +++ + +P ++ ++ A E+ +L++DD+V+ Sbjct: 495 GINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVN 540 >3AQ1-B nrPDB Length = 500 Score = 534 bits (1375), Expect = e-152, Method: Composition-based stats. Identities = 172/483 (35%), Positives = 303/483 (62%), Gaps = 8/483 (1%) Query: 47 MLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQ 106 ML+D MG +V+TNDG IL+E+D+ HPAAK ++E+S+TQD EVGDGTTT +L+GE+L++ Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 107 CAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIH 166 A LI K +H II + + A E+++ ++ + +++AA+ K+ +I K Sbjct: 61 -AEELIMKGVHSTIISEGYRHAAEKCREILETITIAISPDDEAALIKIAGTAITGKGAEA 119 Query: 167 WSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLN 226 + EK+ L + AV+++ + E E ++++ +++EK GG + DS ++ G++++ Sbjct: 120 YKEKLSALTVKAVRSIVE------EEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVID 173 Query: 227 KDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQ 286 K+ HP M +EN +++LL CP+E++K E + I+I L EE+ ++ M E+ Sbjct: 174 KERSHPNMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEK 233 Query: 287 ILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKES 346 ++A +V +KG+ D+AQ+Y+ K G +RRVKKSD R+++VTGATI+ ++ + Sbjct: 234 VIASGANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTE 293 Query: 347 DVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNV 406 DVGT GL + + + +++ C+ KA T++L GG++ +++ +D L DA+ V V Sbjct: 294 DVGT-AGLVEEKEVRGGKMTYVTGCQNSKAVTVLLHGGTEHVVDSLDHALNDALHVVGVV 352 Query: 407 MLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIR 466 + + GGG++E+ +S++L+E A L+G +Q A+A+E IP L +NAG DPI Sbjct: 353 IEDGKVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPID 412 Query: 467 LLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 526 ++ +LR++H +GN G++ G++VDM + EP IK Q++ A+E+ ++LR+DD+ Sbjct: 413 IMVELRSQHEKGNKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAMEATVMILRIDDV 472 Query: 527 VSG 529 V+ Sbjct: 473 VAS 475 >4B2T-A nrPDB Length = 556 Score = 528 bits (1359), Expect = e-150, Method: Composition-based stats. Identities = 162/545 (29%), Positives = 288/545 (52%), Gaps = 26/545 (4%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 M+ P+ +R+TG + N+ AA ++A+++++ LGP + KML+D +G + +TND Sbjct: 1 MEGPLSVFG---DRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITND 57 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G IL+ ++V HPAAK + EL+ QD+EVGDGTT+V+I+A E+L A L+++ IHP Sbjct: 58 GATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKN-ADELVKQKIHPTS 116 Query: 121 IIQALKKALTDALEVIKQ-VSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAV 179 +I + A +A+ I + + D + + S+ +K + + L +DAV Sbjct: 117 VISGYRLACKEAVRYISENLIINTDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAV 176 Query: 180 KTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIE 239 ++ + G+P + ++ + V K G ++S ++ G LN V M + I Sbjct: 177 LAIKY---TDIRGQPRYPVN---SINVLKAHGRSQMESMLINGYALNCVVGSQGMPKRIV 230 Query: 240 NPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEK 299 N ++ LD L+ K + + I E ++I Q E + + ++ILA +++T Sbjct: 231 NAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTG 290 Query: 300 GVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESD------VGTNCG 353 G+ D+ Y ++ G +RRV K D RIA+ +GAT+++ + +L+ + +G Sbjct: 291 GIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEE 350 Query: 354 LFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLS 413 + + I D+ + N K + +++LRG + + +E++R+L DA+ V + V+ S S+ Sbjct: 351 VVQER-ICDDELILIKNTKARTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVV 409 Query: 414 PGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRA 473 PGGGA E A+S+ L A + +Q A ++ IP TL NA D L+++LRA Sbjct: 410 PGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRA 469 Query: 474 KHAQGN--------FTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDD 525 H + G+D GK D G++EP ++K +S+K A E+A +LR+DD Sbjct: 470 FHNEAQVNPERKNLKWIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDD 529 Query: 526 IVSGV 530 ++ Sbjct: 530 LIKLH 534 >3IYF-A nrPDB Length = 521 Score = 522 bits (1344), Expect = e-148, Method: Composition-based stats. Identities = 187/526 (35%), Positives = 311/526 (59%), Gaps = 35/526 (6%) Query: 7 FMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILR 66 + + +R GR AQ NI A + +A+ +R+ LGPK M KML+D +G +V+TNDG ILR Sbjct: 7 VLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILR 66 Query: 67 EIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALK 126 E+ V HPAAK ++E+++TQ++EVGDGTTT +++AGE+L + A L+++N+HP I+++ + Sbjct: 67 EMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRK-AEELLDQNVHPTIVVKGYQ 125 Query: 127 KALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDL 186 A A E++K ++ V ++ + K+ SI K EK+ E+ ++AV V D Sbjct: 126 AAAQKAQELLKTIACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDE 185 Query: 187 GQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLL 246 G+ K +++EK G + D+ ++KGVL++K+ V +M + + + ++ LL Sbjct: 186 GKV----------DKDLIKIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALL 235 Query: 247 DCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQ 306 +C +E E ++ M +I A ++ +KG+ DLAQ Sbjct: 236 NCAIEETASE----------------------MLKDMVAEIKASGANVLFCQKGIDDLAQ 273 Query: 307 HYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFS 366 HYL K G RRVKKSD ++A+ TGA ++ ++DL D+G + GL + I + Sbjct: 274 HYLAKEGIVAARRVKKSDMEKLAKATGANVITNIKDLSAQDLG-DAGLVEERKISGDSMI 332 Query: 367 FLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVK 426 F++ CK PKA T+++RG ++ ++ E+ R + DA+ V + + GGG+TE+ +S+K Sbjct: 333 FVEECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMK 392 Query: 427 LAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTTGID 485 L E A+ + G +Q +A ADA+E IPRTL +NAG D I +L ++RA HA GN G++ Sbjct: 393 LREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLN 452 Query: 486 GDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVR 531 G + DM G+ EP +K Q++++A ES +LLR+DD+++ + Sbjct: 453 VFTGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAEK 498 >4V94-A nrPDB Length = 559 Score = 503 bits (1294), Expect = e-142, Method: Composition-based stats. Identities = 163/538 (30%), Positives = 280/538 (52%), Gaps = 27/538 (5%) Query: 11 SQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDV 70 E+ +G + N+ A AVA+V+++ LGP + KML+D +G +TNDG IL +DV Sbjct: 16 GGEKISGDDIRNQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDV 75 Query: 71 AHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALT 130 HPA K ++EL++ QD E+GDGTT+V+I+A E+L + A L++ IHP II + AL Sbjct: 76 QHPAGKILVELAQQQDREIGDGTTSVVIIASELLKR-ANELVKNKIHPTTIITGFRVALR 134 Query: 131 DALEVIKQ-VSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQT 189 +A+ I + +S VD + + + S+ +K + S+ + +DA+ V+ Q Sbjct: 135 EAIRFINEVLSTSVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKT---QN 191 Query: 190 VEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIE--NPRVVLLD 247 +GE + + + V V K G +S ++ G LN V M + I N ++ LD Sbjct: 192 SKGEIKYPV---KAVNVLKAHGKSATESLLVPGYALNCTVASQAMPKRIAGGNVKIACLD 248 Query: 248 CPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQH 307 L+ + I I+ E +I + E V ++I+ +V+T KG+ DL Sbjct: 249 LNLQKARMAMGVQINIDDPEQLEQIRKREAGIVLERVKKIIDAGAQVVLTTKGIDDLCLK 308 Query: 308 YLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYF-- 365 ++ +RR KK D RIAR TGAT+V+ + +L+ + + L + + F Sbjct: 309 EFVEAKIMGVRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQAKFSD 368 Query: 366 ---SFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMA 422 + + + +I+LRG + L+E++R+L D+++V + + S ++ PGGG E A Sbjct: 369 DECILIKGTSKHSSSSIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVPGGGCVEAA 428 Query: 423 VSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF-- 480 +++ L A + +Q A A+ IP+TL NA D L+++LR+ HA Sbjct: 429 LNIYLDNFATTVGSREQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAK 488 Query: 481 ----------TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 G+D +GKIVD + G+ EP + K +S+K+A+E+ +LR+D +++ Sbjct: 489 PEDVKRRSYRNYGLDLIRGKIVDEIHAGVLEPTISKVKSLKSALEACVAILRIDTMIT 546 >5GW4-d nrPDB Length = 528 Score = 494 bits (1272), Expect = e-140, Method: Composition-based stats. Identities = 147/534 (27%), Positives = 288/534 (53%), Gaps = 18/534 (3%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 M A V + + ++ + +NI AA++VAD IRT LGPK M KM+ G ++++ND Sbjct: 1 MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISND 60 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 GH IL+++ + HP A+ ++E+S QD E GDGTT+V+IL G +L A L+ K IHP I Sbjct: 61 GHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLG-AAERLLNKGIHPTI 119 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 I + + A +++++ ++ V + + + + S+ +K V +S + LA+D+V Sbjct: 120 IADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVL 179 Query: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV-HPKMSRHIE 239 + E N +++ +R+ K GG + D+ ++ GV+L + + E Sbjct: 180 KISD------ENSKNVDLN---DIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKE 230 Query: 240 NPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEK 299 ++ L+ + K +++ NI + ++IL+ E + +C++I + +++ +K Sbjct: 231 KAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQK 290 Query: 300 GV-----SDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGL 354 + +DLA H+L K V++ +++ + +++ G + +E E +G+ + Sbjct: 291 SILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLV 350 Query: 355 FKVEMIGDE--YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSL 412 +++ G + + + N ++++RG + I++E +R+L DA+ V R ++ L Sbjct: 351 EEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGL 410 Query: 413 SPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR 472 GGGA E+ +S +L+++A+ +EG+Q + +Q A A+E IP TL +NAG + I+++++LR Sbjct: 411 IAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELR 470 Query: 473 AKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 526 +KH G GI + + I +P ++ ++ A E +LR+DDI Sbjct: 471 SKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 >4B2T-Z nrPDB Length = 531 Score = 494 bits (1271), Expect = e-140, Method: Composition-based stats. Identities = 145/537 (27%), Positives = 282/537 (52%), Gaps = 22/537 (4%) Query: 3 APVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGH 62 A V +N E + A NI+AA+ + DV+RT LGPK +KML+ G + LT DG+ Sbjct: 2 AAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGN 61 Query: 63 AILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIII 122 +L E+ + HP A + +++ QD+ GDGTT+ +++ GE+L Q A I + +HP II Sbjct: 62 VLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQ-ADLYISEGLHPRIIT 120 Query: 123 QALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTV 182 + + A AL+ ++QV ++ + + + + S+ TK ++ + E +D++ + Sbjct: 121 EGFEAAKEKALQFLEQVKVSKEM-DRETLIDVARTSLRTKVHAELADVLTEAVVDSILAI 179 Query: 183 RKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPR 242 +K + ID+ V + ++ D+ +++G++L+ HP M + +E+ Sbjct: 180 KKQ---------DEPIDL-FMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAY 229 Query: 243 VVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTL-------- 294 ++ + LEY+K E + + E+ ++++ E + ++ ++I+ ++ + Sbjct: 230 ILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGF 289 Query: 295 -VITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCG 353 VI +KG+ + L K G LRR K+ + R+ G +N ++DL +G + G Sbjct: 290 VVINQKGIDPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLG-HAG 348 Query: 354 LFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLS 413 L +G+E F+F++ C P++ T++++G +K L +I ++D + +N + + Sbjct: 349 LVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVV 408 Query: 414 PGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRA 473 PG GA E+A++ L + ++G Q QA ADA+ IP+ L QN+G D L +++A Sbjct: 409 PGAGAVEVAMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQA 468 Query: 474 KHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGV 530 +H++ G+D + G+ + GIW+ +K+Q + + A +L VD+I+ Sbjct: 469 EHSESGQLVGVDLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAG 525 >4B2T-B nrPDB Length = 535 Score = 485 bits (1248), Expect = e-137, Method: Composition-based stats. Identities = 158/538 (29%), Positives = 276/538 (51%), Gaps = 23/538 (4%) Query: 3 APVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDP--MGGLVLTND 60 APV A + A++S+ A A+ D++++ LGPK M K+LL L++TND Sbjct: 7 APVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTND 66 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 G IL+ I V +PAAK ++++SR QD+EVGDGTT+V +LA E+L + A LI K IHP Sbjct: 67 GATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLRE-AESLIAKKIHPQT 125 Query: 121 IIQALKKALTDALEVIKQVSKPVDVEN---DAAMKKLIQASIGTKYVIHWSEKMCELALD 177 II ++A A + + + + + + ++ +K + H + +LA++ Sbjct: 126 IIAGWREATKAARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVE 185 Query: 178 AVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRH 237 AV ++ G N E + V K GG + DS + +G LL+K + + + Sbjct: 186 AVLRLK--------GSGNLE-----AIHVIKKLGGSLADSYLDEGFLLDKKIGVNQ-PKR 231 Query: 238 IENPRVVLLDCPLEYKKGE-SQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVI 296 IEN ++++ + ++ K + + + ++ I E+E+++ E+IL I Sbjct: 232 IENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFI 291 Query: 297 TEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFK 356 + + + + G + R+A VTG I + + + +G+ C L + Sbjct: 292 NRQLIYNYPEQLFGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGS-CKLIE 350 Query: 357 VEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGG 416 MIG++ +ACTI+LRG ++ IL+E +R+L DA+ V + GG Sbjct: 351 EVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGG 410 Query: 417 GATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA 476 G +EM ++ + + A + G + ++ A A+ +P + NAG D L++QLRA H+ Sbjct: 411 GCSEMLMAHAVTQLASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHS 470 Query: 477 QGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV-SGVRKQ 533 +G T G+D +G I DM GI E +K+Q + +A E+A ++LRVD+I+ + RK+ Sbjct: 471 EGKTTAGLDMKEGTIGDMSVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKR 528 >4V8R-AB nrPDB Length = 527 Score = 477 bits (1228), Expect = e-135, Method: Composition-based stats. Identities = 146/530 (27%), Positives = 265/530 (50%), Gaps = 20/530 (3%) Query: 5 VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGL-VLTNDGHA 63 V A++S A AV D++++ LGPK M K+L ++TNDG Sbjct: 3 VQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGAT 62 Query: 64 ILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQ 123 IL+ I + +PAAK ++ +S+ QD+EVGDGTT+V +L+ E+L + + + IHP II+ Sbjct: 63 ILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIE 122 Query: 124 ALKKALTDALEVIKQVSKPVDVEN---DAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 + A AL+ + + + + + + + ++ +K + + ELA +A+ Sbjct: 123 GYRLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAIL 182 Query: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 ++ G N E ++++ KI GG + DS + +G +L K + + + IEN Sbjct: 183 RLK--------GSTNLE-----HIQIIKILGGKLSDSFLDEGFILAKKFGNNQ-PKRIEN 228 Query: 241 PRVVLLDCPLEYKKGE-SQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEK 299 ++++ + L+ K + T +++ ++ + E E+++ +I I + Sbjct: 229 AKILIANTTLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQ 288 Query: 300 GVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEM 359 + D + G + + R+A VTG +V+ ++ + +G C + + M Sbjct: 289 LIYDYPEQLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGE-CDVIEEIM 347 Query: 360 IGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGAT 419 +G++ F CK +ACTI+LRG + L+E +R+L DA++V GGG Sbjct: 348 LGEQPFLKFSGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCA 407 Query: 420 EMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGN 479 EM +S + +A+ ++G + +A A A+ +P L NAG D L+S+LR+ G Sbjct: 408 EMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGI 467 Query: 480 FTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSG 529 T+G+D + G I DM GI E +K+ V +A E+A +LLRVD+I+ Sbjct: 468 STSGLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRA 517 >4B2T-Q nrPDB Length = 548 Score = 474 bits (1219), Expect = e-134, Method: Composition-based stats. Identities = 143/529 (27%), Positives = 260/529 (49%), Gaps = 21/529 (3%) Query: 7 FMNASQERTTG-RQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAIL 65 + + +G +A NI A K +A RT GP M KM+++ + L +TND IL Sbjct: 14 MLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATIL 73 Query: 66 REIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQAL 125 RE++V HPAAK ++ S Q++EVGDGT V++ AG + + A L+ + +I+ Sbjct: 74 RELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGAL-LELAEELLRLGLSVSEVIEGY 132 Query: 126 KKALTDALEVIKQV--SKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVR 183 + A A E++ + ++ + + L+ S+ +K + + +L A ++ Sbjct: 133 EIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEV-FLAKLIAQACVSIF 191 Query: 184 KDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRV 243 D G F +D +RV KI G V S VL G++ K+ +++ ++ Sbjct: 192 PDSGH-------FNVD---NIRVCKILGSGVHSSSVLHGMVFKKET--EGDVTSVKDAKI 239 Query: 244 VLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSD 303 + CP + E++ + I+ E+ + EE + + I +V+T V+D Sbjct: 240 AVYSCPFDGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVAD 299 Query: 304 LAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDE 363 +A HY K ++R K D R+ + GAT + R+ ++G +C + +GD Sbjct: 300 MALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMG-HCDSVYLSEVGDT 358 Query: 364 YFSFLDNCKEPKA-CTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMA 422 + KE A TI+LRG + +++++I+R + D + + + L PGGGATE+ Sbjct: 359 QVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIE 418 Query: 423 VSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTT 482 ++ ++ + G++Q+ + A+A E IPR L +N+G ++S+L A H +GN Sbjct: 419 LAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNV 478 Query: 483 GIDGDKG--KIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSG 529 G+D + + DM+ G+ + + K ++K A +A +LRVD I+ Sbjct: 479 GLDIEAEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMA 527 >5GW5-z nrPDB Length = 546 Score = 469 bits (1206), Expect = e-132, Method: Composition-based stats. Identities = 146/545 (26%), Positives = 267/545 (48%), Gaps = 31/545 (5%) Query: 7 FMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILR 66 +N E A N+T+A+ + V+ T LGPK LKML+D G + LT DG +L Sbjct: 5 LLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLT 64 Query: 67 EIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALK 126 E+ + P A + + QDE GDGTTTV+ L GE+L Q A I++ +HP II + Sbjct: 65 EMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQ-AHRFIQEGVHPRIITDGFE 123 Query: 127 KALTDALEVIKQ--VSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRK 184 A ++++ + + +SK + + ++ ++S+ TK +E + + DAV +V Sbjct: 124 IARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYD 183 Query: 185 DLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVV 244 N ++ + ++++ + D+ +KG++L+ HP M ++N V+ Sbjct: 184 AQAD------NLDLHMVEIMQMQHLSPK---DTTFIKGLVLDHGGRHPDMPTRVKNAYVL 234 Query: 245 LLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPT----------L 294 +L+ LEY+K E + + +++ E + V ++I+ ++ + Sbjct: 235 ILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFV 294 Query: 295 VITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGL 354 +I +KG+ ++ K LRR K+ + R+ VTG N VEDL +G GL Sbjct: 295 IINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGF-SGL 353 Query: 355 FKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSP 414 E IG+E F+++ +PK+CTI+++G + L + ++D + NV+ ++ P Sbjct: 354 VYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIP 413 Query: 415 GGGATEMAVSVKLAEKAKQL---EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQL 471 G GA +A+S L +G + +A A+A+ IP+TL++N+G DP+ +L+ + Sbjct: 414 GAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMV 473 Query: 472 R-----AKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 526 A+ + G+D + G D GIW+ + + ++ A A LL D++ Sbjct: 474 EDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDEL 533 Query: 527 VSGVR 531 + R Sbjct: 534 LRAGR 538 >5GW5-q nrPDB Length = 568 Score = 455 bits (1171), Expect = e-128, Method: Composition-based stats. Identities = 147/543 (27%), Positives = 263/543 (48%), Gaps = 24/543 (4%) Query: 7 FMNASQERTTGRQ-AQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAIL 65 + I +I A + + + T +GP K++++ +G +++TND +L Sbjct: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 Query: 66 REIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQAL 125 RE+D+ HPA K ++ + Q ++GDGT V+ILAGE+L + LI + V IIQ Sbjct: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELL-NVSEKLISMGLSAVEIIQGY 131 Query: 126 KKALTDALEVIKQ--VSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVR 183 A L+ + + V + D + + K+I+ I +K + + EL +AV V Sbjct: 132 NMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILSELVSEAVSHVL 190 Query: 184 KDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV-HPKMSRHIENPR 242 + Q P F +D +RV KI GG + +S V+KG++ N++ H K + + Sbjct: 191 P-VAQQAGEIPYFNVD---SIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHK 246 Query: 243 VVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVS 302 V + CPL+ E++ + + ++ + EE+Q+ M ++I + ++ GV Sbjct: 247 VAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVG 306 Query: 303 DLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGD 362 +LA HYL + G VL+ K + R+ RV GAT + R+ ++G + +E+ GD Sbjct: 307 ELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGD 366 Query: 363 EYFSFLDNCKE-PKACTIMLRGGSKDILNEIDRNLQDAMAVARNVML--SPSLSPGGGAT 419 F E + TI+LRG +++ L++I+R + D +A + +M L PG GAT Sbjct: 367 RVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGAT 426 Query: 420 EMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKH---- 475 E+ + ++ + ++ G+ Q + A A E +PRTL + AG D +L L A H Sbjct: 427 EIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTE 486 Query: 476 ----AQGNFTTGIDGDK---GKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 + G+D D + D+ I++ K+ ++ A E+A +L +D I+ Sbjct: 487 PGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIM 546 Query: 529 GVR 531 + Sbjct: 547 AKK 549 >4V8R-AG nrPDB Length = 590 Score = 445 bits (1145), Expect = e-125, Method: Composition-based stats. Identities = 374/376 (99%), Positives = 375/376 (99%) Query: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND Sbjct: 1 MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 Query: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN Sbjct: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 Query: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG 300 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG Sbjct: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG 300 Query: 301 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI 360 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI Sbjct: 301 VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMI 360 Query: 361 GDEYFSFLDNCKEPKA 376 GDEYFSFLDNCKEP + Sbjct: 361 GDEYFSFLDNCKEPGS 376 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 160/160 (100%), Positives = 160/160 (100%) Query: 375 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQL 434 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQL Sbjct: 431 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQL 490 Query: 435 EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDM 494 EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDM Sbjct: 491 EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDM 550 Query: 495 VSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 534 VSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE Sbjct: 551 VSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 590 >5X9V-A nrPDB Length = 521 Score = 406 bits (1044), Expect = e-113, Method: Composition-based stats. Identities = 130/526 (24%), Positives = 255/526 (48%), Gaps = 33/526 (6%) Query: 9 NASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREI 68 N +QE QA SN A KA+ V+ LGPK + ML+D G +V+TNDG IL + Sbjct: 5 NQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLM 64 Query: 69 DVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKA 128 D HPAA+ ++ ++R Q+ EVGDGTTT +LAG ++++ ++ K + ++ + +A Sbjct: 65 DAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQIL-KGVPVSKVLAGMNRA 123 Query: 129 LTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQ 188 L AL +I++ + V D + K E++ + DA + L Sbjct: 124 LNHALFLIRKNAIKVGSITDDRLLAAA------KIAGRGDERVAAILRDAAAMLEDKL-- 175 Query: 189 TVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDC 248 +P F++ +V D+ ++ GV++NK + + S+ ++ R+++LD Sbjct: 176 ---QDPGFKLADLVLAKVGA-------DTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDD 225 Query: 249 PLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHY 308 L ++ E + E + + +I +E ++ ++ + L++ +G+SD+A+ + Sbjct: 226 GLYPEEVEEEALASEAGFEQYLKNQKIFQENLK----KLKELGVKLILLTRGISDIAEEF 281 Query: 309 LLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESD-----VGTNCGLFKVEMIGDE 363 + V+ R+ + + R+ TGA R K + +G F + Sbjct: 282 CYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLD-- 339 Query: 364 YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 423 F+ ++ T+++ + ++++E +R +DA S + PGGGA + + Sbjct: 340 -FTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSG-VLPGGGAFFLYL 397 Query: 424 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQ-GNFTT 482 S ++ +L G++ + A ++A++ R + +NAG + + L L Q N+ Sbjct: 398 SREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYAL 457 Query: 483 GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 G+D + G+ +DM++ G+ +P + Q+VK A E A LL+++ I+ Sbjct: 458 GLDFETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTIIK 503 >1IOK-A nrPDB Length = 545 Score = 293 bits (751), Expect = 1e-79, Method: Composition-based stats. Identities = 110/546 (20%), Positives = 224/546 (41%), Gaps = 51/546 (9%) Query: 10 ASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREID 69 A++E A+ + +AD ++ LGPK ++ G +T DG ++ +EI+ Sbjct: 2 AAKEVKFNSDARDRMLKGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIE 61 Query: 70 V----AHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQAL 125 + + A+ + E++ ++E GDGTTT +LA I+ + + ++P+ + + + Sbjct: 62 LSDKFENMGAQMVREVASRTNDEAGDGTTTATVLAQAIVREGLKA-VAAGMNPMDLKRGI 120 Query: 126 KKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKD 185 A +E IK ++PV+ ++ A I A+ + +E M + + V TV ++ Sbjct: 121 DVATAKVVEAIKSAARPVNDSSEVAQVGTISANGESFIGQQIAEAMQRVGNEGVITVEEN 180 Query: 186 LGQTVEGE--PNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRV 243 G E E + D + Y+ + D + + + +L +H K ++ P V Sbjct: 181 KGMETEVEVVEGMQFD-RGYLSPYFVTNADKMIAELEDAYIL----LHEKKLSSLQ-PMV 234 Query: 244 VLLDCPLEYKKG----------ESQTNIEIEKEEDWNRILQIEE----EQVQLMCEQILA 289 LL+ ++ +K E+ + + K +I ++ ++ + M + I Sbjct: 235 PLLESVIQSQKPLLIVAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAI 294 Query: 290 VRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKK----SDNNRIARVTG--ATIVNRVEDL 343 + VI+E DL L +L R KK DN I G A I RV + Sbjct: 295 LTGGQVISE----DLGMK-LENVTIDMLGRAKKVSINKDNTTIVDGAGEKAEIEARVSQI 349 Query: 344 KESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDI-LNEIDRNLQDAMAV 402 ++ + + E + + K ++ GG +I + E + DA+ Sbjct: 350 RQQ-IEETTSDYDREKLQERV------AKLAGGVAVIRVGGMTEIEVKERKDRVDDALNA 402 Query: 403 ARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGG 462 R + + GGG + + L + Q + A+E R + +NAG Sbjct: 403 TRAAVQEG-IVVGGGVALVQGAKVLEGLSGA-NSDQDAGIAIIRRALEAPMRQIAENAGV 460 Query: 463 DPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLR 522 D + ++R + G + + DM +G+ +P + + +++ A A LL+ Sbjct: 461 DGAVVAGKVR---ESSDKAFGFNAQTEEYGDMFKFGVIDPAKVVRTALEDAASVAGLLIT 517 Query: 523 VDDIVS 528 + +++ Sbjct: 518 TEAMIA 523 >4V4O-A nrPDB Length = 543 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 114/543 (20%), Positives = 235/543 (43%), Gaps = 47/543 (8%) Query: 18 RQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVA----HP 73 A+ + AVA+ ++ LGP+ +L G +T DG + +E+++ + Sbjct: 9 EAARRALERGVNAVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENI 68 Query: 74 AAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDAL 133 A+ + E++ ++ GDGTTT +LA I+ + + +P+ + + ++KA+ A+ Sbjct: 69 GAQLLKEVASKTNDVAGDGTTTATVLAQAIVREGLKN-VAAGANPLALKRGIEKAVEAAV 127 Query: 134 EVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHW-SEKMCELALDAVKTVRKDLGQTVEG 192 E IK ++ PV E+ A++++ S V ++ M ++ + + TV + E Sbjct: 128 EKIKALAIPV--EDRKAIEEVATISANDPEVGKLIADAMEKVGKEGIITVEESKSLETEL 185 Query: 193 E--PNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLL--NKDVVH-----PKMSRHIENPRV 243 + ++ D K Y+ + + +++ + +L K V + P + + + + Sbjct: 186 KFVEGYQFD-KGYISPYFVTNPETMEAVLEDAFILIVEKKVSNVRELLPILEQVAQTGKP 244 Query: 244 VLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEE----EQVQLMCEQILAVRPTLVITEK 299 +L+ E +GE+ + + K + ++ ++ + M + I AV VI+E Sbjct: 245 LLIIA--EDVEGEALATLVVNKLRGTLSVAAVKAPGFGDRRKEMLKDIAAVTGGTVISE- 301 Query: 300 GVSDLAQHYLLKGGCSVLRRVKK----SDNNRIARVTGAT--IVNRVEDLKESDVGTNCG 353 +L L S+L R ++ D I G I R+ +K+ + T Sbjct: 302 ---ELGFK-LENATLSMLGRAERVRITKDETTIVGGKGKKEDIEARINGIKKE-LETTDS 356 Query: 354 LFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDI-LNEIDRNLQDAMAVARNVMLSPSL 412 + E + + K ++ G + + L E +DA+ R + + Sbjct: 357 EYAREKLQERL------AKLAGGVAVIRVGAATETELKEKKHRFEDALNATRAAVEEG-I 409 Query: 413 SPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLR 472 PGGG T + + E K+LEG + + V A+E R + +NAG + ++ Q+ Sbjct: 410 VPGGGVTLLRAISAVEELIKKLEGDEATGAKIVRRALEEPARQIAENAGYEGSVIVQQIL 469 Query: 473 AKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS-GVR 531 A+ G + G+ VDMV GI +P + + +++ A L+L + +V+ Sbjct: 470 AETKNPR--YGFNAATGEFVDMVEAGIVDPAKVTRSALQNAASIGALILTTEAVVAEKPE 527 Query: 532 KQE 534 K+E Sbjct: 528 KKE 530 >4PJ1-A nrPDB Length = 558 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 108/552 (19%), Positives = 220/552 (39%), Gaps = 41/552 (7%) Query: 5 VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAI 64 + F ++++ G A+ + +AD + +GPK ++ G +T DG + Sbjct: 23 LYFQGSAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTV 82 Query: 65 LREIDV----AHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 + ID+ + AK + +++ +EE GDGTTT +LA I + I K +PV Sbjct: 83 AKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEK-ISKGANPVE 141 Query: 121 IIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVK 180 I + + A+ + +K+ SKPV + A I A+ + S+ M ++ V Sbjct: 142 IRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVI 201 Query: 181 TVRK--DLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSR-- 236 TV+ L +E + D + Y+ I +L + + Sbjct: 202 TVKDGKTLNDELEIIEGMKFD-RGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIV 260 Query: 237 ---HIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEE----EQVQLMCEQILA 289 I N L E GE+ + + + + + +++ ++ + + + + Sbjct: 261 PALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAI 320 Query: 290 VRPTLVITEKG----VSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTG--ATIVNRVEDL 343 V E+G + D+ H L K G ++ D+ + + G A I R++++ Sbjct: 321 ATGGAVFGEEGLTLNLEDVQPHDLGKVGKVIVT----KDDAMLLKGKGDKAQIEKRIQEI 376 Query: 344 KESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDI-LNEIDRNLQDAMAV 402 E + ++ E + + K ++ GG+ D+ +NE + DA+ Sbjct: 377 IEQ-LDVTTSEYEKEKLNERL------AKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNA 429 Query: 403 ARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGG 462 R + + GGG + L E Q+ + + ++ T+ +NAG Sbjct: 430 TRAAVEEG-IVLGGGCALLRCIPALDSLTPANE-DQKIGIEIIKRTLKIPAMTIAKNAGV 487 Query: 463 DPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLR 522 + ++ ++ ++ G D G V+MV GI +P + + ++ A A LL Sbjct: 488 EGSLIVEKIMQSSSE----VGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTT 543 Query: 523 VDDIVSGVRKQE 534 + +V+ + K+E Sbjct: 544 AEVVVTEIPKEE 555 >4AAR-A nrPDB Length = 548 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 109/546 (19%), Positives = 229/546 (41%), Gaps = 40/546 (7%) Query: 10 ASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREID 69 A+++ G A++ + +AD ++ LGPK +L G +T DG ++ REI+ Sbjct: 2 AAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIE 61 Query: 70 V----AHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQAL 125 + + A+ + E++ ++ GDGTTT +LA I+ + + ++P+ + + + Sbjct: 62 LEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKA-VAAGMNPMDLKRGI 120 Query: 126 KKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKD 185 KA+T A+E +K +S P A I A+ +E M ++ + V TV Sbjct: 121 DKAVTAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDG 180 Query: 186 LG--QTVEGEPNFEIDIKRYVRVEKI----PGGDVLDSRVLKGVLLNKDVVHPK----MS 235 G ++ + D + Y+ I G L+S + +L +K + + + + Sbjct: 181 TGLQDELDVVEGMQFD-RGYLSPYFINKPETGAVELESPFI--LLADKKISNIREMLPVL 237 Query: 236 RHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEE----EQVQLMCEQILAVR 291 + LL + + GE+ + + ++ ++ ++ + M + I + Sbjct: 238 EAVAKAGKPLLIIAEDVE-GEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLT 296 Query: 292 PTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTG--ATIVNRVEDLKESDVG 349 VI+E+ +L + L G R V D I G A I RV +++ + Sbjct: 297 GGTVISEEIGMELEKATLEDLG-QAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQ-IE 354 Query: 350 TNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDI-LNEIDRNLQDAMAVARNVML 408 + E + + K ++ G + ++ + E ++ A+ R + Sbjct: 355 EATSDYDREKLQERV------AKLAGGVAVIKVGAATEVEMKEKKARVEAALHATRAAVE 408 Query: 409 SPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLL 468 + GGG + V+ KLA+ Q E Q + AME R ++ N G +P + Sbjct: 409 EG-VVAGGGVALIRVASKLADLRGQNE-DQNVGIKVALRAMEAPLRQIVLNCGEEPSVVA 466 Query: 469 SQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 + ++ G+ G + + +M+ GI +P + + +++ A A L++ + +V+ Sbjct: 467 NTVKG----GDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVT 522 Query: 529 GVRKQE 534 + K + Sbjct: 523 DLPKND 528 >5DA8-A nrPDB Length = 545 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 94/545 (17%), Positives = 225/545 (41%), Gaps = 39/545 (7%) Query: 11 SQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDV 70 +++ +A+ +A+ ++ LGP ++ G T DG + +EI++ Sbjct: 3 AKDILFDAEARTKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIEL 62 Query: 71 AHP----AAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALK 126 P A+ + E++ + GDGTTT +LA I + + P+ + + + Sbjct: 63 VDPVENMGAQMVREVASKTSDVAGDGTTTATVLAQAIYREGLKN-VTAGARPIDLKRGID 121 Query: 127 KALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDL 186 +A+ + + ++ +S+ + + + A I A+ + +E M ++ D V TV + Sbjct: 122 RAVKEVVAELRNISRSISGKKEIAQVGTISANNDPEIGELIAEAMDKVGKDGVITVEEAK 181 Query: 187 GQTVEGE--PNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLL--NKDVVH-----PKMSRH 237 G E + + D + Y+ + + +++ + + ++L +K + + P + + Sbjct: 182 GMETELKVVEGMQFD-RGYLSPYFVTNSETMEAELDEALILIHDKKISNMKELLPILEKA 240 Query: 238 IENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEE----EQVQLMCEQILAVRPT 293 ++ R +L+ E +GE+ + + K ++ ++ ++ + M E I + Sbjct: 241 AQSGRPLLIIA--EDIEGEALATLVVNKLRGTLKVAAVKAPGFGDRRKAMLEDIAILTGG 298 Query: 294 LVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGA--TIVNRVEDLKESDVGTN 351 VI+E+ L + G R DN I G I R+ ++K + + Sbjct: 299 TVISEEKGYKLENATMAYLG-QAARITIDKDNTTIVEGKGKQEEIKARINEIKGQ-IEKS 356 Query: 352 CGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDI-LNEIDRNLQDAMAVARNVMLSP 410 + E + + K ++ G S ++ + E ++DA+ R + Sbjct: 357 TSDYDTEKLQERL------AKLSGGVAVLKIGASTEVEMKEKKARVEDALHATRAAVQEG 410 Query: 411 SLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAG-GDPIRLLS 469 + GGG + + LA+ A Q+ + + A+E R ++ N G D +L Sbjct: 411 -IVVGGGVALIRAAKGLAK-AVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLE 468 Query: 470 QLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSG 529 +++ G + + +++ G+ +P + + +++ A A +LL + ++ Sbjct: 469 KVK----NAEGDYGFNARTEQYENLIEAGVVDPTKVTRSALENAASVASILLTTEAAITD 524 Query: 530 VRKQE 534 V++ + Sbjct: 525 VKEDK 529 >1GN1-A nrPDB Length = 178 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 107/172 (62%), Positives = 143/172 (83%) Query: 214 VLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRIL 273 + DS VL+GV++NKDV HP+M R+I+NPR+VLLD LEYKKGESQT+IEI +EED+ RIL Sbjct: 1 MEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRIL 60 Query: 274 QIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTG 333 Q+EEE + +CE I+ ++P +VITEKG+SDLAQHYL++ + +RRV+K+DNNRIAR G Sbjct: 61 QMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACG 120 Query: 334 ATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGS 385 A IV+R E+L+E DVGT GL +++ IGDEYF+F+ +CK+PKACTI+LRG S Sbjct: 121 ARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGAS 172 >1SJP-A nrPDB Length = 504 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 98/507 (19%), Positives = 215/507 (42%), Gaps = 48/507 (9%) Query: 52 MGGLVLTNDGHAILREIDVAHP----AAKSMLELSRTQDEEVGDGTTTVIILAGEILAQC 107 G +TNDG +I +EI++ P A+ + E+++ D+ GDGTTT +LA ++ + Sbjct: 1 WGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREG 60 Query: 108 APYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHW 167 + +P+ + + ++KA+ E + + +K V+ + A I A + Sbjct: 61 L-RNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQS-IGDLI 118 Query: 168 SEKMCELALDAVKTVRKD--LGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLL 225 +E M ++ + V TV + G +E D K Y+ + + ++ + +L Sbjct: 119 AEAMDKVGNEGVITVEESNTFGLQLELTEGMRFD-KGYISGYFVTDPERQEAVLEDPYIL 177 Query: 226 -------NKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEE- 277 + P + + I + +L+ E +GE+ + + + K + + ++ Sbjct: 178 LVSSKVSTVKDLLPLLEKVIGAGKPLLIIA--EDVEGEALSTLVVNKIRGTFKSVAVKAP 235 Query: 278 ---EQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKK----SDNNRIAR 330 ++ + M + + + VI+E ++ L S+L + +K D I Sbjct: 236 GFGDRRKAMLQDMAILTGGQVISE----EVGL-TLENADLSLLGKARKVVVTKDETTIVE 290 Query: 331 VTGAT--IVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDI 388 G T I RV ++ ++ + + E + + K ++ G + ++ Sbjct: 291 GAGDTDAIAGRVAQIR-QEIENSDSDYDREKLQERL------AKLAGGVAVIKAGAATEV 343 Query: 389 -LNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVAD 447 L E ++DA+ A+ + + GGG T + + L E +LEG + V Sbjct: 344 ELKERKHRIEDAVRNAKAAVEEG-IVAGGGVTLLQAAPTLDEL--KLEGDEATGANIVKV 400 Query: 448 AMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQ 507 A+E + + N+G +P + ++R A G++ G D+++ G+ +P + + Sbjct: 401 ALEAPLKQIAFNSGLEPGVVAEKVRNLPA----GHGLNAQTGVYEDLLAAGVADPVKVTR 456 Query: 508 QSVKTAIESACLLLRVDDIVSGVRKQE 534 +++ A A L L + +V+ ++E Sbjct: 457 SALQNAASIAGLFLTTEAVVADKPEKE 483 >1E0R-B nrPDB Length = 159 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 58/154 (37%), Positives = 99/154 (64%), Gaps = 1/154 (0%) Query: 220 LKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQ 279 + G++++K+ VHP M +++ ++ LLD PLE KK E TN+ IE + L EE Sbjct: 1 MNGIIVDKEKVHPGMPDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENM 60 Query: 280 VQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNR 339 ++ M ++I +V +VIT+KG+ D+AQHYL + G +RRVKKSD +++A+ TGA+IV+ Sbjct: 61 LREMVDKIKSVGANVVITQKGIDDMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVST 120 Query: 340 VEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKE 373 ++++ SD+GT + +G++Y +F+ K Sbjct: 121 IDEISSSDLGTAER-VEQVKVGEDYMTFVTGSKN 153 >5CDI-A nrPDB Length = 552 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 94/559 (16%), Positives = 205/559 (36%), Gaps = 80/559 (14%) Query: 19 QAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHP----A 74 QA +A V+ +GPK +L G + NDG I RE++++ P Sbjct: 12 QALKRMQAGVDKLATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPVENIG 71 Query: 75 AKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALE 134 A + + + ++ GDGTTT +L+ +A+ ++ +PV +++ ++K + + ++ Sbjct: 72 ATLVRQAAARTNDTAGDGTTTATVLSAAFIAEGMK-IVSAGTNPVQLVRGMEKTVQELVK 130 Query: 135 VIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEP 194 ++++S V + D A + A T S+ M ++ V T+ + Sbjct: 131 ELRKMSSVVQTDKDLANVACVSAGGNTDIGSLISDAMAKVGRTGVVTMEE---------- 180 Query: 195 NFEIDIKRYVRVEKIPGGDVLDSR-VLKGVLLNKDVVHP-------KMSRHIENPRVVLL 246 G D ++G+ + P +M EN +++L+ Sbjct: 181 ----------------GKTAEDQLVFVEGMQFERGYTSPYFVTDPERMICEYENCKILLV 224 Query: 247 DCPLEYKK---GESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSD 303 D + + ++ I +E L+ ++ + I G + Sbjct: 225 DKKISTARDIITILESAIRGNYPLLIMAEEVEQEALATLVVNKLRGTLKVVAIKAPGFGE 284 Query: 304 LAQHYLLKGGCSVLRRVKKSDN----------------------NRIARV----TGATIV 337 YL V + + R V T A + Sbjct: 285 RRSSYLEDIAILTGGTVVRDEMGVSLEQATDAVLGTAAKITITKERTTVVGDGSTAADVA 344 Query: 338 NRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGG-SKDILNEIDRNL 396 RV+ ++ + ++ E + + + I+ G ++ L E + Sbjct: 345 ARVKQIRNLQM-QTDQDYEREKLQERI------ARLSGGVAIIQVGAQTETELKEKKLRV 397 Query: 397 QDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEG-IQQWPYQAVADAMECIPRT 455 +DA+ R + + PGGG T + +S K+ +++ QQ + A+ + Sbjct: 398 EDALNATRAAVEEG-VVPGGGCTLLRLSEKVDVIKRRMTDPEQQMGADIIKRALCYPIKL 456 Query: 456 LIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIE 515 + QNAG + +++++ G + +++ GI +P + + S++ A+ Sbjct: 457 IAQNAGVNGSVVMNEVMK--NLDRPHYGYNAATDSFENLMETGIIDPSKVVRCSMENAVS 514 Query: 516 SACLLLRVDDIVSGVRKQE 534 A L D +V+ +++ E Sbjct: 515 VAKTFLLADVVVTELKEIE 533 >1ASS-A nrPDB Length = 159 Score = 172 bits (437), Expect = 3e-43, Method: Composition-based stats. Identities = 54/154 (35%), Positives = 86/154 (55%), Gaps = 1/154 (0%) Query: 220 LKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQ 279 + G++++K+ VH KM ++N ++ L+D LE KK E + ++I L E Sbjct: 1 MSGIVIDKEKVHSKMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNT 60 Query: 280 VQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNR 339 + M E+I +V+ +KG+ D+AQHYL K G +RRVKKSD ++A+ TGA IV Sbjct: 61 FKQMVEKIKKSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTD 120 Query: 340 VEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKE 373 ++DL S +G + IGD+ +F+ CK Sbjct: 121 LDDLTPSVLGEAET-VEERKIGDDRMTFVMGCKN 153 >3LXD-A nrPDB Length = 415 Score = 44.6 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 25/197 (12%), Positives = 58/197 (29%), Gaps = 30/197 (15%) Query: 303 DLAQHYLLKGGCS---VLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEM 359 L++ YL + +R + ++ + GA +V+ +G + Sbjct: 52 PLSKEYLAREKTFERICIRPAQFWEDKAVEMKLGAEVVSLDPAAHTVKLGDGSAIEY--- 108 Query: 360 IGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGAT 419 + + + + + D + + ++ GGG Sbjct: 109 ---GKLIWATGGDPRRLSCVGADLAGVHAVRTKEDA--DRLMAELDAGAKNAVVIGGGYI 163 Query: 420 EMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGN 479 + + L + + +E +PR L + AG LS+ + Sbjct: 164 GLEAAAVLTKFGVNVT------------LLEALPRVLARVAG----EALSEFY---QAEH 204 Query: 480 FTTGIDGDKGKIVDMVS 496 G+D G +D + Sbjct: 205 RAHGVDLRTGAAMDCIE 221 >3E0V-A nrPDB Length = 539 Score = 36.9 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 21/91 (23%), Positives = 37/91 (40%), Gaps = 16/91 (17%) Query: 4 PVVFMNASQERTTGRQAQISNITA-----AKAVADVIRTCLGPKAMLKML---------L 49 P V + G + + I A A+ V D +R LGPK M+ + Sbjct: 228 PAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQVGD-VRKALGPKGRDIMIICKIENHQGV 286 Query: 50 DPMGGLVLTNDGHAILR-EIDVAHPAAKSML 79 + ++ +DG + R ++ V PA K ++ Sbjct: 287 QNIDSIIEESDGIMVARGDLGVEIPAEKVVV 317 >3OSX-A nrPDB Length = 201 Score = 35.0 bits (79), Expect = 0.089, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 45/125 (36%), Gaps = 8/125 (6%) Query: 254 KGESQTNIEIEKEEDWNRILQIEE----EQVQLMCEQILAVRPTLVITEKGVSDLAQHYL 309 +GE+ + + ++ ++ ++ + M + I + VI+E+ +L + L Sbjct: 77 EGEALATLVVNNMRGIVKVASVKAPGFGDRRKAMLQDIATLTNGTVISEEIGLELEKATL 136 Query: 310 LKGGCSVLRRVKKSDNNRIARVTG--ATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSF 367 G R V D I G I RV +++ + + + E + + Sbjct: 137 EDLG-QAKRVVINKDTTTIIDGVGEEGAIAARVTQIRQQ-IEESTSDYDREKLQERVAKL 194 Query: 368 LDNCK 372 K Sbjct: 195 AGGVK 199 >1KID-A nrPDB Length = 203 Score = 34.2 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 44/117 (37%), Gaps = 8/117 (6%) Query: 254 KGESQTNIEIEKEEDWNRILQIEE----EQVQLMCEQILAVRPTLVITEKGVSDLAQHYL 309 +GE+ + + ++ ++ ++ + M + I + VI+E+ +L + L Sbjct: 82 EGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATL 141 Query: 310 LKGGCSVLRRVKKSDNNRIARVTG--ATIVNRVEDLKESDVGTNCGLFKVEMIGDEY 364 G R V D I G A I RV +++ + + E + + Sbjct: 142 EDLG-QAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQ-IEEATSDYDREKLQERV 196 >3BWN-A nrPDB Length = 391 Score = 32.3 bits (72), Expect = 0.48, Method: Composition-based stats. Identities = 14/74 (18%), Positives = 27/74 (36%), Gaps = 15/74 (20%) Query: 377 CTIMLRGG--SKDILN----------EIDRNLQDAMAVARNVM-LSPSLSPGGGATEM-- 421 CT+ +RG + E++ ++D V N + G G+T++ Sbjct: 46 CTVTIRGCDLMSYFSDMTNLCWFLEPELEDAIKDLHGVVGNAATEDRYIVVGTGSTQLCQ 105 Query: 422 AVSVKLAEKAKQLE 435 A L+ A+ Sbjct: 106 AAVHALSSLARSQP 119 >2GJN-A nrPDB Length = 328 Score = 31.9 bits (71), Expect = 0.69, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 27/69 (39%), Gaps = 2/69 (2%) Query: 362 DEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLS--PGGGAT 419 F C A +R + + I R+L++ VARN + L+ GGA Sbjct: 201 GTRFLATRECPIHPAVKAAIRAADERSTDLIMRSLRNTARVARNAISQEVLAIEARGGAG 260 Query: 420 EMAVSVKLA 428 ++ ++ Sbjct: 261 YADIAALVS 269 >5NNO-A nrPDB Length = 546 Score = 31.9 bits (71), Expect = 0.72, Method: Composition-based stats. Identities = 18/109 (16%), Positives = 43/109 (39%), Gaps = 12/109 (11%) Query: 53 GGLVLTNDGHAILREIDVAHPAAKSMLE-LSRTQDEEVGDGTTTVIILAGEILAQCAPYL 111 G + D + + ++ +++ L+ + +GD + +L GE+L + Sbjct: 256 GQTSIAPDYVVVEKSME------SVLVDALAEARKAMLGD--KFLKVLKGELLVKQKQQF 307 Query: 112 IEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIG 160 +E++ +P I+ + +E +K V E D A + + Sbjct: 308 LEESDYPRIVNASH---FQRLMEFMKGGKVAVGGEADEATLTIAPTILT 353 >1IIR-A nrPDB Length = 415 Score = 31.5 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 46/163 (28%), Gaps = 14/163 (8%) Query: 27 AAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSRTQD 86 A + D IR +L LVL +DG +V H + + Sbjct: 254 AVRVAIDAIRA----HGRRVILSRGWADLVLPDDGADCFAIGEVNH---QVLFGRVAAVI 306 Query: 87 EEVGDGTTTVIILAGE---ILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPV 143 G GTT V AG +L Q A + + A + +S + Sbjct: 307 HHGGAGTTHVAARAGAPQILLPQMADQPYYAG---RVAELGVGVAHDGPIPTFDSLSAAL 363 Query: 144 DVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDL 186 ++ + L LDAV + + Sbjct: 364 ATALTPETHARA-TAVAGTIRTDGAAVAARLLLDAVSREKPTV 405 >5LY3-A nrPDB Length = 432 Score = 30.4 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 50/148 (33%), Gaps = 6/148 (4%) Query: 330 RVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDIL 389 G + + L + E+ + + +P A I + I+ Sbjct: 121 EFAGWLVAVALSALAPDYMYKAIFDIYDELASEFKIYAVTILPQPLAVAIAENAVNCVIV 180 Query: 390 NEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVK--LAEKAKQLEGIQQWPYQAVAD 447 N+Q A ++ ++ G E + L + +++ + V Sbjct: 181 EGGHGNIQVAPISFA-LIREGLVALNRGGAEANAITREILKDIGYSDIAREEYAVEVVKR 239 Query: 448 AMECIPRTLIQ---NAGGDPIRLLSQLR 472 A+ +PR L + A DP R ++++R Sbjct: 240 AVGLVPRRLKEAIRAAKSDPDRFVTKVR 267 >4FLV-A nrPDB Length = 793 Score = 30.4 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 30/78 (38%), Gaps = 7/78 (8%) Query: 269 WNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKG------GCSVLRRVKK 322 + ++ E E ++ + + I P ++IT G + A YLLK + R + Sbjct: 202 YVEVVSSEREMIKRLVKVIREKDPDVIITYNG-DNFAFPYLLKRAEKLGIKLPLGRDNSE 260 Query: 323 SDNNRIARVTGATIVNRV 340 R+ I R+ Sbjct: 261 PKMQRMGDSLAVEIKGRI 278 >5H12-A nrPDB Length = 775 Score = 30.0 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 23/166 (13%), Positives = 58/166 (34%), Gaps = 14/166 (8%) Query: 181 TVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIEN 240 +R+ E + + + IP + ++ + + + ++ + + Sbjct: 99 KIREHSAVIDIFEYDIPFAKRYLIDKGLIPMEGDEELKL---LAFDIETLYHEGEEFAKG 155 Query: 241 PRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKG 300 P +++ E K + I++ + ++ E E ++ + I P ++IT G Sbjct: 156 PIIMISYADEEEAKVITWKKIDLP----YVEVVSSEREMIKRFLKVIREKDPDVIITYNG 211 Query: 301 VSDLAQHYLLKG------GCSVLRRVKKSDNNRIARVTGATIVNRV 340 YL+K + R + R+ +T I R+ Sbjct: 212 -DSFDLPYLVKRAEKLGIKLPLGRDGSEPKMQRLGDMTAVEIKGRI 256 >1SRV-A nrPDB Length = 145 Score = 30.0 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 55/139 (39%), Gaps = 18/139 (12%) Query: 200 IKRYVRVEKIPGGDVLDSRVLKGVLL--NKDVVH-----PKMSRHIENPRVVLLDCPLEY 252 K Y+ + + +++ + +L K V + P + + + + +L+ E Sbjct: 5 DKGYISPYFVTNPETMEAVLEDAFILIVEKKVSNVRELLPILEQVAQTGKPLLIIA--ED 62 Query: 253 KKGESQTNIEIEKEEDWNRILQIEE----EQVQLMCEQILAVRPTLVITEKGVSDLAQHY 308 +GE+ + + K + ++ ++ + M + I AV VI+E +L Sbjct: 63 VEGEALATLVVNKLRGTLSVAAVKAPGFGDRRKEMLKDIAAVTGGTVISE----ELGFK- 117 Query: 309 LLKGGCSVLRRVKKSDNNR 327 L S+L R ++ + Sbjct: 118 LENATLSMLGRAERVRITK 136 >1NKQ-A nrPDB Length = 259 Score = 29.6 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 22/123 (17%), Positives = 46/123 (37%), Gaps = 11/123 (8%) Query: 4 PVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHA 63 P F+ + T S++ A+ L G + + G Sbjct: 34 PFFFLKPTSSIVTP---LSSSLVKTTRPANSTFNGLNEDGTNP------GPIFIPR-GVK 83 Query: 64 ILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQ 123 + EI++A +K + +++ + EEV D + + + LA ++ A+ +K P I + Sbjct: 84 VHHEIELALIVSKHLSNVTKMKPEEVYD-SISGVALALDLTARNVQDEAKKKGLPWTISK 142 Query: 124 ALK 126 Sbjct: 143 GFD 145 >5YJJ-A nrPDB Length = 713 Score = 28.4 bits (62), Expect = 7.0, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 58/160 (36%), Gaps = 8/160 (5%) Query: 42 KAMLKMLLDPMGGLVLTNDGHA-ILREIDVAHPAAKSMLEL---SRTQDEEVGDGTTTVI 97 + M L D + T DG I +I + + + E +R + D I Sbjct: 498 QGMEDALGDMDFKVAGTKDGITAIQMDIKIDGLTREVIEEALEQARQGRLAIMDHMLHTI 557 Query: 98 ILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQA 157 E L+ AP ++ +I+P I + E+I + +D+E D + Sbjct: 558 EQPREELSAYAPKVVTMSINPDKIRDVIGPGGKKINEIIDETGVKLDIEQDGT---IFIG 614 Query: 158 SIGTKYVIHWSEKMCELALDA-VKTVRKDLGQTVEGEPNF 196 ++ + E + ++ +A V V + +E F Sbjct: 615 AVDQAMINRAKEIIEDITREAEVGQVYHAKVKRIEKYGAF 654 >3FTB-A nrPDB Length = 361 Score = 28.4 bits (62), Expect = 7.6, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 29/67 (43%), Gaps = 2/67 (2%) Query: 407 MLSPSLSPGGGATE-MAVSVKLAEKAK-QLEGIQQWPYQAVADAMECIPRTLIQNAGGDP 464 + + G GA+E + +S+ L EK + ++ A + + L +N D Sbjct: 76 LKDIGIVLGNGASEIIELSISLFEKILIIVPSYAEYEINAKKHGVSVVFSYLDENMCIDY 135 Query: 465 IRLLSQL 471 ++S++ Sbjct: 136 EDIISKI 142 >1Q1R-A nrPDB Length = 431 Score = 28.4 bits (62), Expect = 7.6, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 37/114 (32%), Gaps = 15/114 (13%) Query: 394 RNLQDAMAVARNVMLSPSLSP-GGGATEMAVSVK----------LAEKAKQLEGIQQWPY 442 R L+DA + R ++ L GGG + V+ L A+ LE + P Sbjct: 134 RTLEDAECIRRQLIADNRLVVIGGGYIGLEVAATAIKANMHVTLLDTAARVLERVTAPPV 193 Query: 443 QAVADAME----CIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIV 492 A + + RT Q G + ++ A + D I Sbjct: 194 SAFYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGTRLPADLVIAGIG 247 >1PW5-A nrPDB Length = 253 Score = 28.4 bits (62), Expect = 8.3, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 87/243 (35%), Gaps = 32/243 (13%) Query: 166 HWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLL 225 + + + +L+ ++T+++ + V N + + YVR + G DV D V+ Sbjct: 17 YLDDSLLPGSLEFLETLKEKNKRFVFFTNNSSLGAQDYVRKLRNMGVDVPD----DAVVT 72 Query: 226 NKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCE 285 + ++ M + R+ LL P + KK I++E +L ++ + Sbjct: 73 SGEITAEHMLKRFGRCRIFLLGTP-QLKKVFEAYGHVIDEENPDFVVLGFDKTLTYERLK 131 Query: 286 QILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSD--------NNRIARVTGAT-- 335 + ++ KG +A H + K I TG Sbjct: 132 K------ACILLRKGKFYIATH----PDINC---PSKEGPVPDAGSIMAAIEASTGRKPD 178 Query: 336 -IVNRVEDLKESDVGTNCGLFKVEM--IGDEYFSFLDNCKEPKACTIMLRGGSKDILNEI 392 I + L + G+ K M +GD ++ + K +I++ G + ++ Sbjct: 179 LIAGKPNPLVVDVISEKFGVPKERMAMVGDRLYTDVKLGKNAGIVSILVLTG-ETTPEDL 237 Query: 393 DRN 395 +R Sbjct: 238 ERA 240 >2AP9-A nrPDB Length = 299 Score = 28.1 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 25/65 (38%) Query: 372 KEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKA 431 + ++ GG+ + + R MA RN + P + GGG A+ +L + Sbjct: 22 QLHGKVVVVKYGGNAMTDDTLRRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIEG 81 Query: 432 KQLEG 436 G Sbjct: 82 DFKGG 86 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.139 0.346 Lambda K H 0.267 0.0428 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,345,217 Number of Sequences: 36641 Number of extensions: 730004 Number of successful extensions: 2649 Number of sequences better than 10.0: 67 Number of HSP's better than 10.0 without gapping: 78 Number of HSP's successfully gapped in prelim test: 37 Number of HSP's that attempted gapping in prelim test: 2290 Number of HSP's gapped (non-prelim): 123 length of query: 534 length of database: 10,336,785 effective HSP length: 102 effective length of query: 432 effective length of database: 6,599,403 effective search space: 2850942096 effective search space used: 2850942096 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 62 (28.4 bits)