BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P38123 (315 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6BX3-A nrPDB 648 0.0 6CHG-A nrPDB 325 2e-89 2H9P-A nrPDB 158 2e-39 5M25-A nrPDB 158 3e-39 5NNZ-B nrPDB 86 2e-17 5I2T-A nrPDB 77 7e-15 5WLC-LO nrPDB 77 1e-14 1VYH-C nrPDB 76 2e-14 5WYJ-BC nrPDB 73 2e-13 5MZH-A nrPDB 71 7e-13 6GMH-W nrPDB 69 2e-12 6QX9-5O nrPDB 69 3e-12 6HHQ-h nrPDB 69 4e-12 6F3T-A nrPDB 68 5e-12 4U1E-I nrPDB 67 7e-12 6MZM-G nrPDB 66 2e-11 5Z56-q nrPDB 65 3e-11 4LG8-A nrPDB 65 3e-11 5OPT-p nrPDB 65 3e-11 4V7E-Bg nrPDB 65 5e-11 4V8M-A7 nrPDB 62 3e-10 6HQA-B nrPDB 62 3e-10 5GAN-H nrPDB 60 1e-09 6EMK-B nrPDB 60 1e-09 3DM0-A nrPDB 60 1e-09 6Q8F-A nrPDB 60 1e-09 6G51-g nrPDB 60 2e-09 5FL8-q nrPDB 59 3e-09 3JB9-L nrPDB 59 3e-09 5NZU-C nrPDB 57 7e-09 6QDV-o nrPDB 57 8e-09 5K0Y-T nrPDB 57 9e-09 5YZG-W nrPDB 57 9e-09 3FM0-A nrPDB 57 1e-08 3JAP-g nrPDB 57 1e-08 4J0W-A nrPDB 57 1e-08 5UZ7-B nrPDB 56 3e-08 5Y88-O nrPDB 55 3e-08 5OQL-J nrPDB 55 4e-08 2YNP-A nrPDB 54 7e-08 5WYK-BB nrPDB 54 9e-08 3MKQ-A nrPDB 54 1e-07 6ID0-T nrPDB 53 2e-07 3JB9-g nrPDB 53 2e-07 2HES-X nrPDB 51 6e-07 3ACP-A nrPDB 51 7e-07 6J6H-n nrPDB 51 8e-07 6BX3-B nrPDB 50 9e-07 5FVM-C nrPDB 50 2e-06 5XYI-g nrPDB 49 3e-06 4V6W-Ag nrPDB 49 4e-06 6N9G-C nrPDB 48 7e-06 6EOJ-D nrPDB 47 9e-06 3ODT-A nrPDB 47 1e-05 6QX9-4B nrPDB 47 1e-05 5WLC-LU nrPDB 47 1e-05 2AQ5-A nrPDB 47 2e-05 5MWJ-A nrPDB 45 3e-05 4OWR-A nrPDB 45 3e-05 4AEZ-A nrPDB 45 3e-05 3BG0-A nrPDB 45 4e-05 4BTS-AR nrPDB 45 5e-05 5OQL-L nrPDB 45 5e-05 1NR0-A nrPDB 43 2e-04 5OV3-A nrPDB 42 3e-04 5OQL-X nrPDB 42 5e-04 4N14-A nrPDB 42 5e-04 6E29-D nrPDB 42 5e-04 4GGA-A nrPDB 42 5e-04 5LCW-Q nrPDB 41 5e-04 5G04-R nrPDB 41 5e-04 5OQL-d nrPDB 41 7e-04 3JB9-S nrPDB 41 8e-04 5WBU-D nrPDB 41 8e-04 3C9C-A nrPDB 40 0.001 5N4A-A nrPDB 40 0.002 5CXC-A nrPDB 39 0.002 5K1B-B nrPDB 39 0.003 5WLC-LJ nrPDB 39 0.003 6CHG-D nrPDB 39 0.004 4YCZ-A nrPDB 39 0.004 1PI6-A nrPDB 38 0.005 5WYJ-BE nrPDB 38 0.005 5BJS-A nrPDB 37 0.010 5A9Q-7 nrPDB 37 0.013 6ELZ-p nrPDB 37 0.015 6IYY-A nrPDB 36 0.024 4G56-B nrPDB 36 0.024 4XFV-A nrPDB 36 0.025 4XYI-A nrPDB 35 0.036 4BZK-B nrPDB 35 0.038 3JRP-A nrPDB 35 0.038 4BFG-A nrPDB 35 0.045 3JRO-A nrPDB 34 0.065 5M89-A nrPDB 33 0.11 5K19-A nrPDB 33 0.12 5MC6-j nrPDB 33 0.20 5LTD-A nrPDB 33 0.20 5L9T-R nrPDB 32 0.27 5WLC-LW nrPDB 32 0.33 3DW8-B nrPDB 32 0.35 4AV8-A nrPDB 32 0.45 5CXB-B nrPDB 31 0.64 3NTX-A nrPDB 31 0.81 5FA5-B nrPDB 31 0.86 3JZG-A nrPDB 30 0.98 4A11-B nrPDB 30 1.0 5A9Q-0 nrPDB 30 1.0 4BFE-A nrPDB 30 1.2 1G73-A nrPDB 30 1.4 2VNU-D nrPDB 30 1.5 3W15-A nrPDB 30 1.5 3HZH-A nrPDB 30 1.6 4R40-A nrPDB 30 1.9 5YZG-2 nrPDB 29 2.1 3EI3-B nrPDB 29 2.4 5JVV-B nrPDB 29 2.5 2ECF-A nrPDB 29 3.2 6CB1-s nrPDB 28 4.7 5AMS-A nrPDB 28 5.0 6C0F-s nrPDB 28 5.3 6EM1-m nrPDB 28 5.4 4TX5-A nrPDB 28 6.3 1H5Q-A nrPDB 27 8.1 >6BX3-A nrPDB Length = 314 Score = 648 bits (1671), Expect = 0.0, Method: Compositional matrix adjust. Identities = 314/314 (100%), Positives = 314/314 (100%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL Sbjct: 1 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL 60 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 121 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK Sbjct: 61 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 120 Query: 122 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 181 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK Sbjct: 121 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 180 Query: 182 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC Sbjct: 181 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 240 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC 301 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC Sbjct: 241 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC 300 Query: 302 SLALNGDCCLWRWV 315 SLALNGDCCLWRWV Sbjct: 301 SLALNGDCCLWRWV 314 >6CHG-A nrPDB Length = 312 Score = 325 bits (832), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 167/314 (53%), Positives = 227/314 (72%), Gaps = 5/314 (1%) Query: 1 MFQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSE 60 M QF V +G +T +ISPDG+ +AI Q ++L+Y+I+ + + L T+H + Sbjct: 1 MLQFDKQVLPASGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMK-LTTTHKECINC 59 Query: 61 LCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESI 120 LCWSPD +CIA+ S+DF+VEI H+ YG + +GHTAPVIS+ +N KGN+L +SSMDESI Sbjct: 60 LCWSPDSKCIASGSEDFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESI 119 Query: 121 KIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYD 180 K W L+G+ +KT+SAHS+AVVS+D+P DSSILSSGSYDGLIRIFD E+GHCLKTLTYD Sbjct: 120 KEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYD 179 Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE-KGVLHH 239 KDW E+GVVPIS VKFS N ++LLVKSLD VVK+W+ G VVRTF E K L + Sbjct: 180 KDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKY 239 Query: 240 SCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNI 299 +CG++ + P+ G PLVISG ++G + WN +K+L+Q +D H +SP++SI + Sbjct: 240 NCGLELIYPQ-GKDPLVISGNDSGSMCVWNVYSKNLVQKIDEK--HRNSPLISISASYDK 296 Query: 300 MCSLALNGDCCLWR 313 + +L+LNG+C L+R Sbjct: 297 VATLSLNGECNLFR 310 >2H9P-A nrPDB Length = 329 Score = 158 bits (400), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 111/322 (34%), Positives = 164/322 (50%), Gaps = 33/322 (10%) Query: 6 TPVGTQNGLKATCA---------KISPDGQFLAITQGLNIL-IYDINRRTVSQTLVTSHA 55 TPV LK T A K SP+G++LA + ++ I+ +T ++ H Sbjct: 24 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT-ISGHK 82 Query: 56 RPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTS 114 S++ WS D + +ASDD +++I +S G L T GH+ V FN + NL+ + Sbjct: 83 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 142 Query: 115 SMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCL 174 S DES++IWD G +KT+ AHS+ V +V D S++ S SYDGL RI+D +G CL Sbjct: 143 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCL 201 Query: 175 KTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEK 234 KTL D + P+S VKFS N +Y+L +LD +K+WD G ++T+ EK Sbjct: 202 KTLIDDDN-------PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 254 Query: 235 GVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH 294 + F N ++SG E+ +Y WN TK ++Q L G H+ V+S Sbjct: 255 YCI-------FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG----HTDVVISTA 303 Query: 295 CF--GNIMCSLALNGDCCLWRW 314 C NI+ S AL D + W Sbjct: 304 CHPTENIIASAALENDKTIKLW 325 >5M25-A nrPDB Length = 434 Score = 158 bits (400), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 111/322 (34%), Positives = 164/322 (50%), Gaps = 33/322 (10%) Query: 6 TPVGTQNGLKATCA---------KISPDGQFLAITQGLNIL-IYDINRRTVSQTLVTSHA 55 TPV LK T A K SP+G++LA + ++ I+ +T ++ H Sbjct: 129 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT-ISGHK 187 Query: 56 RPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTS 114 S++ WS D + +ASDD +++I +S G L T GH+ V FN + NL+ + Sbjct: 188 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 247 Query: 115 SMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCL 174 S DES++IWD G +KT+ AHS+ V +V D S++ S SYDGL RI+D +G CL Sbjct: 248 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCL 306 Query: 175 KTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEK 234 KTL D + P+S VKFS N +Y+L +LD +K+WD G ++T+ EK Sbjct: 307 KTLIDDDN-------PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 359 Query: 235 GVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH 294 + F N ++SG E+ +Y WN TK ++Q L G H+ V+S Sbjct: 360 YCI-------FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG----HTDVVISTA 408 Query: 295 CF--GNIMCSLALNGDCCLWRW 314 C NI+ S AL D + W Sbjct: 409 CHPTENIIASAALENDKTIKLW 430 >5NNZ-B nrPDB Length = 415 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/285 (25%), Positives = 123/285 (43%), Gaps = 48/285 (16%) Query: 64 SPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 +P G IAT S D + ++ + G HTF GHTA ++ L+FN + L+ T SMD + K+ Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203 Query: 123 WDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 WD NG + T+ HS ++S+ + I+ +GS+D + ++DA+TG + L Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWDADTGRKVNILI---- 258 Query: 183 WKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE--------K 234 IS F+ + +L S+D K+WD G V T E Sbjct: 259 ----GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314 Query: 235 GVLHHSCGMD---------------FLNPEDGSTPLV---------ISGYENGDIYCWNS 270 G L + D L +G + ++G + W++ Sbjct: 315 GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374 Query: 271 DTKSLLQLLDGSLYHHSSPVMS--IHCFGNIMCSLALNGDCCLWR 313 T LQ+L+G H+ + S + GNI+ + + + C +WR Sbjct: 375 QTGQCLQVLEG----HTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 95/213 (44%), Gaps = 12/213 (5%) Query: 18 CAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 C +P +A + ++DI TL H+ L ++ G I T S D Sbjct: 182 CLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL-RGHSAEIISLSFNTSGDRIITGSFD 240 Query: 77 FSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 +V + G ++ IGH A + S +FN +L+ T SMD++ K+WD NG + T++ Sbjct: 241 HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT 300 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 H + ++ ++++ S DG RIF A T C+ L E IS++ Sbjct: 301 GHDDEILDSCFDYT-GKLIATASADGTARIFSAATRKCIAKL--------EGHEGEISKI 351 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 F+ +LL S D +IWD G ++ + Sbjct: 352 SFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE 384 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 52/230 (22%), Positives = 98/230 (42%), Gaps = 24/230 (10%) Query: 85 SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAV--V 142 ++ L H P+ ++ N+ G+ T S D + K+WDT +G + T+ H V + Sbjct: 81 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI 140 Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR 202 + + P D +++GS+D +++ ETG C T I + F+ + Sbjct: 141 AFNNPYGDK--IATGSFDKTCKLWSVETGKCYHTF--------RGHTAEIVCLSFNPQST 190 Query: 203 YLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN 262 + S+D K+WD G V T + E L + D +I+G + Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD----------RIITGSFD 240 Query: 263 GDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + W++DT + +L G SS + C +++ + +++ C LW Sbjct: 241 HTVVVWDADTGRKVNILIGHCAEISSASFNWDC--SLILTGSMDKTCKLW 288 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 33/117 (28%), Positives = 57/117 (48%), Gaps = 2/117 (1%) Query: 51 VTSHARPFSELCWSPDGQCIATASDDFSVEIIHLS-YGLLHTFIGHTAPVISLTFNRKGN 109 +T H + C+ G+ IATAS D + I + + GH + ++FN +GN Sbjct: 299 LTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358 Query: 110 LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 L T S D++ +IWD G ++ + H++ + S +I+ +GS D RI+ Sbjct: 359 HLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYK-GNIVITGSKDNTCRIW 414 >5I2T-A nrPDB Length = 742 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 49/182 (26%), Positives = 90/182 (49%), Gaps = 14/182 (7%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLF 112 H + L +SPDG + TAS+D +++ ++ G L TF HT+ V ++ F ++G ++F Sbjct: 369 HFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMF 428 Query: 113 TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGL-IRIFDAETG 171 +SS+D +++ WD + +T + + ++ +GS D I ++ +TG Sbjct: 429 SSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTG 488 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQP 231 L L+ + P+S + FS+ L S D ++IW G R+ QV+P Sbjct: 489 QLLDALSGHEG--------PVSCLSFSQENSVLASASWDKTIRIWSIFG----RSQQVEP 536 Query: 232 LE 233 +E Sbjct: 537 IE 538 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 100/220 (45%), Gaps = 28/220 (12%) Query: 98 PVISLTFNRKGN-LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSS 156 PV +++ N+ G L F SS + +++ + S + H ++ S+ + S ++++ Sbjct: 329 PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTA 388 Query: 157 GSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW 216 S DG I+++D +G CL T E ++ V+F++ + + SLDG V+ W Sbjct: 389 -SEDGKIKVWDITSGFCLATF--------EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW 439 Query: 217 DCIGGCVVRTFQ-VQPLEKGVLHHSCGMDFLNPEDGSTPLVISG-YENGDIYCWNSDTKS 274 D I RTF + ++ L D S +V +G +N DI+ W+ T Sbjct: 440 DLIRYRNFRTFTGTERIQFNCL----------AVDPSGEVVCAGSLDNFDIHVWSVQTGQ 489 Query: 275 LLQLLDGSLYHHSSPV--MSIHCFGNIMCSLALNGDCCLW 312 LL L G H PV +S +++ S + + +W Sbjct: 490 LLDALSG----HEGPVSCLSFSQENSVLASASWDKTIRIW 525 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/150 (24%), Positives = 71/150 (47%), Gaps = 5/150 (3%) Query: 36 ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS-DDFSVEIIHLSYG-LLHTFI 93 + +D+ R +T + F+ L P G+ + S D+F + + + G LL Sbjct: 436 VRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALS 495 Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS-LMKTISAHSEAVVSVDVPMNDSS 152 GH PV L+F+++ ++L ++S D++I+IW S ++ I +S+ + P D Sbjct: 496 GHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRP--DGK 553 Query: 153 ILSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 ++ + G I IF+ E + + KD Sbjct: 554 EVAVSTLKGQISIFNIEDAKQVGNIDCRKD 583 Score = 32.0 bits (71), Expect = 0.34, Method: Compositional matrix adjust. Identities = 33/130 (25%), Positives = 55/130 (42%), Gaps = 17/130 (13%) Query: 54 HARPFSELC----WSPDGQCIATASDDF---------SVEIIHLSYGLLHTFIGHTAPVI 100 H F E C +SPDG+ A AS F + + + GH + Sbjct: 116 HHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDIT 175 Query: 101 SLTFNRKGNLLFTSSMDESIKIW--DTLNGSLMK-TISAHSEAVVSVDVPMNDSSILSSG 157 SLT+++ + T+S D S KIW D+ +L T + H + V+ + I + Sbjct: 176 SLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTV- 234 Query: 158 SYDGLIRIFD 167 S DG + +++ Sbjct: 235 SKDGAVFVWE 244 >5WLC-LO nrPDB Length = 923 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 14/175 (8%) Query: 61 LCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDES 119 L +SPDG + TAS+D +++ ++ G L TF HT+ V ++ F ++G ++F+SS+D + Sbjct: 351 LAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGT 410 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGL-IRIFDAETGHCLKTLT 178 ++ WD + +T + + ++ +GS D I ++ +TG L L+ Sbjct: 411 VRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALS 470 Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 + P+S + FS+ L S D ++IW G R+ QV+P+E Sbjct: 471 GHEG--------PVSCLSFSQENSVLASASWDKTIRIWSIFG----RSQQVEPIE 513 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 99/219 (45%), Gaps = 26/219 (11%) Query: 98 PVISLTFNRKGN-LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSS 156 PV +++ N+ G L F SS + +++ + S + H ++ S+ + S ++++ Sbjct: 304 PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTA 363 Query: 157 GSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW 216 S DG I+++D +G CL T E ++ V+F++ + + SLDG V+ W Sbjct: 364 -SEDGKIKVWDITSGFCLATF--------EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW 414 Query: 217 DCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG-YENGDIYCWNSDTKSL 275 D I RTF + +C D S +V +G +N DI+ W+ T L Sbjct: 415 DLIRYRNFRTFTGTER----IQFNCL-----AVDPSGEVVCAGSLDNFDIHVWSVQTGQL 465 Query: 276 LQLLDGSLYHHSSPV--MSIHCFGNIMCSLALNGDCCLW 312 L L G H PV +S +++ S + + +W Sbjct: 466 LDALSG----HEGPVSCLSFSQENSVLASASWDKTIRIW 500 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 37/150 (24%), Positives = 71/150 (47%), Gaps = 5/150 (3%) Query: 36 ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS-DDFSVEIIHLSYG-LLHTFI 93 + +D+ R +T + F+ L P G+ + S D+F + + + G LL Sbjct: 411 VRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALS 470 Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS-LMKTISAHSEAVVSVDVPMNDSS 152 GH PV L+F+++ ++L ++S D++I+IW S ++ I +S+ + P D Sbjct: 471 GHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRP--DGK 528 Query: 153 ILSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 ++ + G I IF+ E + + KD Sbjct: 529 EVAVSTLKGQISIFNIEDAKQVGNIDCRKD 558 Score = 31.6 bits (70), Expect = 0.42, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 13/83 (15%) Query: 54 HARPFSELC----WSPDGQCIATASDDF---------SVEIIHLSYGLLHTFIGHTAPVI 100 H F E C +SPDG+ A AS F + + + GH + Sbjct: 91 HHFNFKEKCSAVKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDIT 150 Query: 101 SLTFNRKGNLLFTSSMDESIKIW 123 SLT+++ + T+S D S KIW Sbjct: 151 SLTWSQDSRFILTTSKDLSAKIW 173 >1VYH-C nrPDB Length = 410 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 114/275 (41%), Gaps = 58/275 (21%) Query: 44 RTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISL 102 R + ++ H P + + + P + +AS+D ++++ G T GHT V + Sbjct: 97 RPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDI 156 Query: 103 TFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGL 162 +F+ G LL + S D +IK+WD ++T+ H V SV + N I+S+ S D Sbjct: 157 SFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSA-SRDKT 215 Query: 163 IRIFDAETGHCLKTLTYDKDWKR------------------------------------- 185 I++++ +TG+C+KT T ++W R Sbjct: 216 IKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREH 275 Query: 186 -----------ENGVVPISQVKFSENAR------YLLVKSLDGVVKIWDC-IGGCVVRTF 227 E+ IS+ SE + +LL S D +K+WD G C++ Sbjct: 276 RHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV 335 Query: 228 QVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN 262 +GVL HS G L+ D T L + Y+N Sbjct: 336 GHDNWVRGVLFHSGGKFILSCADDKT-LRVWDYKN 369 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 60/266 (22%), Positives = 109/266 (40%), Gaps = 40/266 (15%) Query: 25 GQFLA-ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIH 83 G+ LA + + I ++D +T+ H S + P+G I +AS D ++++ Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTM-HGHDHNVSSVSIMPNGDHIVSASRDKTIKMWE 220 Query: 84 LSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVV 142 + G + TF GH V + N+ G L+ + S D+++++W + H V Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVE 280 Query: 143 SVD-VPMNDSSILS------------------SGSYDGLIRIFDAETGHCLKTLTYDKDW 183 + P + S +S SGS D I+++D TG CL TL +W Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW 340 Query: 184 KRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGM 243 R GV+ F +++L + D +++WD ++T H + Sbjct: 341 VR--GVL------FHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHE------HFVTSL 386 Query: 244 DFLNPEDGSTPLVISGYENGDIYCWN 269 DF + P V++G + + W Sbjct: 387 DFHK----TAPYVVTGSVDQTVKVWE 408 >5WYJ-BC nrPDB Length = 817 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 49/139 (35%), Positives = 74/139 (53%), Gaps = 2/139 (1%) Query: 40 DINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLH-TFIGHTAP 98 D+ VS+ +H + + L SP+ ATAS D + +I +L G L T H Sbjct: 476 DVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRG 535 Query: 99 VISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS 158 + ++F + LL TSS D+++KIW S+MKT+ H+ AV ++S G+ Sbjct: 536 LWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGA 595 Query: 159 YDGLIRIFDAETGHCLKTL 177 DGLI+I+D +G CLKTL Sbjct: 596 -DGLIKIWDCSSGECLKTL 613 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 67/291 (23%), Positives = 118/291 (40%), Gaps = 27/291 (9%) Query: 16 ATCAKISPDGQFLA--ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 + A +S +G+ LA + +NI+ R + + + + L +PDGQ + Sbjct: 20 SAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTYV 79 Query: 74 SDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 133 S ++I HL G + + ++P L + LL D SI + D NG + + Sbjct: 80 SQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHS 139 Query: 134 ISAHSEAVVSVDVPMNDSS---ILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV 190 H + S+ +S +L+SG +G+++++D CL TL R G+ Sbjct: 140 FKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVR--GLD 197 Query: 191 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 I E + LL D ++ +WD + + P+ + V SCG FL D Sbjct: 198 IIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQV--ESCG--FLKDGD 253 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGS----LYHHSSPVMSIHCFG 297 G + +G GD ++ QL+D L + P+ + G Sbjct: 254 GKRIIYTAG---GD---------AIFQLIDSESGSVLKRTNKPIEELFIIG 292 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 44/156 (28%), Positives = 75/156 (48%), Gaps = 14/156 (8%) Query: 72 TASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 131 TAS D V+II +S H H + +L+ + ++ T+S D++ KIW+ NG L Sbjct: 472 TASMD--VQIIKVSEYTRH---AHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELE 526 Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 191 T++ H + V D +L++ S D ++I+ +T +KTL E Sbjct: 527 ATLANHKRGLWDVSFCQYD-KLLATSSGDKTVKIWSLDTFSVMKTL--------EGHTNA 577 Query: 192 ISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 + + F + L+ DG++KIWDC G ++T Sbjct: 578 VQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTL 613 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 46/176 (26%), Positives = 84/176 (47%), Gaps = 13/176 (7%) Query: 3 QFVTPVGTQNGLKATCAKISPDGQFLA-ITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 + + + ++ + T K++PDGQ+L ++Q + I+ + V +++ S P L Sbjct: 51 KILHKISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKIS--SPSYIL 108 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTF----NRKGNLLFTSSM 116 +A D S+ ++ + G + H+F GH + SL F N K LL + Sbjct: 109 DADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDT 168 Query: 117 DESIKIWDTLNGSLMKTISAHSEAVVSVD---VPMNDSSILS--SGSYDGLIRIFD 167 + +K+WD + + T+ H+ AV +D VP ND L+ SG D +I ++D Sbjct: 169 NGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWD 224 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 33/120 (27%), Positives = 62/120 (51%), Gaps = 2/120 (1%) Query: 48 QTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHL-SYGLLHTFIGHTAPVISLTFNR 106 + + +H R ++ + + +AT+S D +V+I L ++ ++ T GHT V +F Sbjct: 526 EATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFIN 585 Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 K L + D IKIWD +G +KT+ H+ + ++ MND ++ S DG+ + + Sbjct: 586 KQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALST-MNDGDMIVSADADGVFQFW 644 >5MZH-A nrPDB Length = 452 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 60/256 (23%), Positives = 107/256 (41%), Gaps = 26/256 (10%) Query: 61 LCWSPDGQCIATASDDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFTSSMDES 119 L ++P IAT S D + ++ + G T GH A ++SL FN G+L+ T S D Sbjct: 185 LSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHD 244 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY 179 ++WD G + +S H V S +++ SGS D R++D +G CL Sbjct: 245 SRLWDVRTGQCVHVLSGHRGEVSSTQFNYA-GTLVVSGSIDCTSRLWDVRSGRCLSV--- 300 Query: 180 DKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHH 239 ++ + V F ++ S DG +++ + G T E + Sbjct: 301 -----KQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVA- 354 Query: 240 SCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMS--IHCFG 297 NP+ +I+ + W+ DT LQ+L+G H+ + S + G Sbjct: 355 ------FNPQG---TRLITASSDKTCRLWDCDTGECLQVLEG----HTDEIFSCAFNYEG 401 Query: 298 NIMCSLALNGDCCLWR 313 + + + + + C +W+ Sbjct: 402 DFIITGSKDNTCRIWK 417 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/243 (25%), Positives = 100/243 (41%), Gaps = 30/243 (12%) Query: 76 DFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 D +E H S+ L H P+ + FN+ G+ T S D + K+W+T G + T+ Sbjct: 74 DKMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLE 133 Query: 136 AHSEAV--VSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 193 H V ++ + P D + +GS+D +++DA TG TL + +V +S Sbjct: 134 GHKNVVYAIAFNNPYGDKIV--TGSFDKTCKLWDAYTGQLYYTLK-----GHQTEIVCLS 186 Query: 194 QVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGST 253 F+ + + S+D K+WD G T E L + G D Sbjct: 187 ---FNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGD--------- 234 Query: 254 PLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNG--DCCL 311 L+++G + D W+ T + +L G H V S N +L ++G DC Sbjct: 235 -LIVTGSFDHDSRLWDVRTGQCVHVLSG----HRGEVSSTQF--NYAGTLVVSGSIDCTS 287 Query: 312 WRW 314 W Sbjct: 288 RLW 290 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/259 (23%), Positives = 104/259 (40%), Gaps = 22/259 (8%) Query: 18 CAKISPDGQFLAITQGLNIL-IYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 C +P +A N ++D+ TL H L ++ G I T S D Sbjct: 184 CLSFNPQSTIIATGSMDNTAKLWDVETGQERATLA-GHRAEIVSLGFNTGGDLIVTGSFD 242 Query: 77 FSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 + + G +H GH V S FN G L+ + S+D + ++WD +G + Sbjct: 243 HDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQ 302 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 H++ V+ V + ++S+ S DG R++ TG C TL + IS+V Sbjct: 303 GHTDEVLDVAFDAAGTKMVSA-SADGSARLYHTLTGVCQHTLVGHEG--------EISKV 353 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 F+ L+ S D ++WDC G ++ + E SC ++ Sbjct: 354 AFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEI----FSCAFNY------EGDF 403 Query: 256 VISGYENGDIYCWNSDTKS 274 +I+G ++ W + T S Sbjct: 404 IITGSKDNTCRIWKALTAS 422 >6GMH-W nrPDB Length = 305 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 104/209 (49%), Gaps = 16/209 (7%) Query: 14 LKATCAKISPDGQFLAI---TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI 70 + A SPD Q+LA +NI + ++ S + + + + +SPDG+ + Sbjct: 107 VDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYS---LDTRGKFILSIAYSPDGKYL 163 Query: 71 ATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 A+ + D + I ++ G LLHT GH P+ SLTF+ LL T+S D IKI+D + + Sbjct: 164 ASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHAN 223 Query: 130 LMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGV 189 L T+S H+ V++V +D+ +SS S ++++D T C+ T +D Sbjct: 224 LAGTLSGHASWVLNVAFCPDDTHFVSSSSD-KSVKVWDVGTRTCVHTFFDHQD------- 275 Query: 190 VPISQVKFSENARYLLVKSLDGVVKIWDC 218 + VK++ N ++ D + I+DC Sbjct: 276 -QVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 37/136 (27%), Positives = 69/136 (50%), Gaps = 11/136 (8%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHS-EAVVSVDVPMNDSS 152 GH V+S+ + + +SS+D I++WD NG +K+I A +A P DS Sbjct: 62 GHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSP--DSQ 119 Query: 153 ILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGV 212 L++G++ G + IF E+G K++ + I + +S + +YL ++DG+ Sbjct: 120 YLATGTHVGKVNIFGVESGK--------KEYSLDTRGKFILSIAYSPDGKYLASGAIDGI 171 Query: 213 VKIWDCIGGCVVRTFQ 228 + I+D G ++ T + Sbjct: 172 INIFDIATGKLLHTLE 187 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 45/168 (26%), Positives = 76/168 (45%), Gaps = 10/168 (5%) Query: 61 LCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP-VISLTFNRKGNLLFTSSMDES 119 L +SPD Q +AT + V I + G + ++S+ ++ G L + ++D Sbjct: 112 LAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGI 171 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY 179 I I+D G L+ T+ H+ + S+ DS +L + S DG I+I+D + + TL+ Sbjct: 172 INIFDIATGKLLHTLEGHAMPIRSLTFS-PDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230 Query: 180 DKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 W + V F + + + S D VK+WD V TF Sbjct: 231 HASW--------VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 33/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%) Query: 128 GSLMKTISAHSEAVVSVDVPMN---DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 G L K AH +A+ SV N +S + +GS D L++++ + D W Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWK------WRDERLDLQWS 59 Query: 185 RENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD 244 E + + V S SLD +++WD G +++ P++ L S Sbjct: 60 LEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQ 119 Query: 245 FLNPEDGSTPLVISGYENG 263 +L + I G E+G Sbjct: 120 YLATGTHVGKVNIFGVESG 138 >6QX9-5O nrPDB Length = 357 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 63/259 (24%), Positives = 114/259 (44%), Gaps = 51/259 (19%) Query: 65 PDGQCIATASDDFSVEIIHLSYG---LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 121 P+G +A+A D + + ++ YG T GH+ V+ L +N G++LF++S D+++ Sbjct: 76 PNGSTLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 134 Query: 122 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTL--TY 179 +WD+ G +K + H+ V S ++ +GS DG ++++D ++T TY Sbjct: 135 VWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTY 194 Query: 180 -------------------DKDWK----RENGVV--------PISQVKFSENARYLLVKS 208 D D K R+N + ++ + S YLL + Sbjct: 195 QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNA 254 Query: 209 LDGVVKIWD----CIGGCVVRTFQ--VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN 262 +D V++WD V+ FQ V EK +L S DGS + +G + Sbjct: 255 MDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWS------PDGSK--IAAGSAD 306 Query: 263 GDIYCWNSDTKSLLQLLDG 281 +Y W++ ++ +L L G Sbjct: 307 RFVYVWDTTSRRILYKLPG 325 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 91/220 (41%), Gaps = 22/220 (10%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG-SLMKTISAHSEAVVSVDVPMNDSS 152 GH V F+ G+ L ++ D I +W+ T+ HS AV+ + D S Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY-NTDGS 122 Query: 153 ILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGV 212 +L S S D + ++D+ETG +K L + N P + + + S DG Sbjct: 123 MLFSASTDKTVAVWDSETGERVKRLKGHTSFV--NSCYPARR-----GPQLVCTGSDDGT 175 Query: 213 VKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDT 272 VK+WD ++TFQ + + F + D +ISG + DI W+ Sbjct: 176 VKLWDIRKKAAIQTFQ-------NTYQVLAVTFNDTSD----QIISGGIDNDIKVWDLRQ 224 Query: 273 KSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 L + G + S +S+ G+ + S A++ +W Sbjct: 225 NKLTYTMRG--HADSVTGLSLSSEGSYLLSNAMDNTVRVW 262 Score = 30.4 bits (67), Expect = 0.96, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 29/59 (49%), Gaps = 1/59 (1%) Query: 63 WSPDGQCIATASDDFSVEIIH-LSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESI 120 WSPDG IA S D V + S +L+ GH + + F+ ++ ++S D+ + Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351 >6HHQ-h nrPDB Length = 319 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 52/191 (27%), Positives = 89/191 (46%), Gaps = 14/191 (7%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPM 148 + +F GH+ V T G ++S D+++++WD G + H V+SVD+ Sbjct: 58 VRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDK 117 Query: 149 NDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKS 208 S I+ SGS D I+++ + G CL TL DW + VVP K +++ ++ Sbjct: 118 KASMII-SGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVP--NEKADDDSVTIISAG 173 Query: 209 LDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 D +VK W+ + FQ+ E + H+ ++ L T L+ S ++G+I W Sbjct: 174 NDKMVKAWN------LNQFQI---EADFIGHNSNINTLTASPDGT-LIASAGKDGEIMLW 223 Query: 269 NSDTKSLLQLL 279 N K + L Sbjct: 224 NLAAKKAMYTL 234 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 43/214 (20%), Positives = 88/214 (41%), Gaps = 35/214 (16%) Query: 35 NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIAT-----------------ASDDF 77 +++ DI+++ +++ S +R + W+ GQC+AT +DD Sbjct: 109 DVMSVDIDKKA---SMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDD 165 Query: 78 SVEIIHL------------SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT 125 SV II + + FIGH + + +LT + G L+ ++ D I +W+ Sbjct: 166 SVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNL 225 Query: 126 LNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKR 185 M T+SA E P + L++ + G I++F + + + L + Sbjct: 226 AAKKAMYTLSAQDEVFSLAFSP--NRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYS 282 Query: 186 ENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI 219 + + +S + + L D V+++W + Sbjct: 283 KAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVM 316 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 29/117 (24%), Positives = 55/117 (47%), Gaps = 11/117 (9%) Query: 22 SPDGQFLAIT-QGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD---- 76 SPDG +A + I+++++ + TL ++ FS L +SP+ +A A+ Sbjct: 205 SPDGTLIASAGKDGEIMLWNLAAKKAMYTL-SAQDEVFS-LAFSPNRYWLAAATATGIKV 262 Query: 77 FSVEIIHLSYGLLHTFIGHTAPV----ISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 FS++ +L L F G++ +SL ++ G LF D I++W + + Sbjct: 263 FSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 319 >6F3T-A nrPDB Length = 608 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/238 (24%), Positives = 107/238 (44%), Gaps = 21/238 (8%) Query: 35 NILIYDINRRTVSQ-TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHL-SYGLLHTF 92 ++L ++ +T S+ ++ H+ P +SPD + ++S+D +V + L ++ L + Sbjct: 330 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 389 Query: 93 IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSS 152 GH PV F+ G + D ++W T + ++ + H V N S+ Sbjct: 390 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN-SN 448 Query: 153 ILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGV 212 +++GS D +R++D G+C++ T K PI + FS N R+L + DG Sbjct: 449 YVATGSADRTVRLWDVLNGNCVRIFTGHKG--------PIHSLTFSPNGRFLATGATDGR 500 Query: 213 VKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 V +WD G +V KG C + F DG ++ SG + + W++ Sbjct: 501 VLLWDIGHGLMVGEL------KGHTDTVCSLRF--SRDGE--ILASGSMDNTVRLWDA 548 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 43/167 (25%), Positives = 73/167 (43%), Gaps = 10/167 (5%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHLS-YGLLHTFIGHTAPVISLTFNRKGNLLF 112 H P + +SP G + D + Y L F GH A V F+ N + Sbjct: 392 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 451 Query: 113 TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 T S D ++++WD LNG+ ++ + H + S+ N L++G+ DG + ++D G Sbjct: 452 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN-GRFLATGATDGRVLLWDIGHGL 510 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI 219 + L D + ++FS + L S+D V++WD I Sbjct: 511 MVGELKGHTD--------TVCSLRFSRDGEILASGSMDNTVRLWDAI 549 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 38/140 (27%), Positives = 70/140 (50%), Gaps = 5/140 (3%) Query: 18 CAKISPDGQFLAI-TQGLNILIYDI-NRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 C + P+ ++A + + ++D+ N V + T H P L +SP+G+ +AT + Sbjct: 440 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVR--IFTGHKGPIHSLTFSPNGRFLATGAT 497 Query: 76 DFSVEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 134 D V + + +GL+ GHT V SL F+R G +L + SMD ++++WD + Sbjct: 498 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET 557 Query: 135 SAHSEAVVSVDVPMNDSSIL 154 + A +++P N +L Sbjct: 558 DDFTTATGHINLPENSQELL 577 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/250 (22%), Positives = 99/250 (39%), Gaps = 26/250 (10%) Query: 66 DGQCIATASDDFSVEII-HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 D I SDD I+ + L GH+ PV +F+ N L +SS D ++++W Sbjct: 320 DLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS 379 Query: 125 TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 + + H+ V + SG +D + R++ + L+ Sbjct: 380 LQTFTCLVGYKGHNYPVWDTQFSPYGYYFV-SGGHDRVARLWATDHYQPLRIFA------ 432 Query: 185 RENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD 244 + ++ +F N+ Y+ S D V++WD + G VR F KG +H Sbjct: 433 --GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGH---KGPIHSLT--- 484 Query: 245 FLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF--GNIMCS 302 +P + + +G +G + W+ L+ G L H+ V S+ G I+ S Sbjct: 485 -FSP---NGRFLATGATDGRVLLWDIGHG----LMVGELKGHTDTVCSLRFSRDGEILAS 536 Query: 303 LALNGDCCLW 312 +++ LW Sbjct: 537 GSMDNTVRLW 546 Score = 32.0 bits (71), Expect = 0.34, Method: Compositional matrix adjust. Identities = 32/118 (27%), Positives = 51/118 (43%), Gaps = 29/118 (24%) Query: 21 ISPDGQFLAI--TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS---- 74 SP+G+FLA T G +L++DI + L H L +S DG+ +A+ S Sbjct: 485 FSPNGRFLATGATDG-RVLLWDIGHGLMVGEL-KGHTDTVCSLRFSRDGEILASGSMDNT 542 Query: 75 ---------------DDFSVEIIHLSYG------LLHTFIGHTAPVISLTFNRKGNLL 111 DDF+ H++ LL T++ + PV+ L F R+ +L Sbjct: 543 VRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVL 600 >4U1E-I nrPDB Length = 347 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 53/183 (28%), Positives = 88/183 (48%), Gaps = 24/183 (13%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 GH P+ + +N++G+LLF+ S D S +W +LNG + T+ H+ + S+DV + Sbjct: 8 GHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCF-TKY 66 Query: 154 LSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVV 213 +GS D I+++D G C+ T WK VP+ +V+FS Y L LD V+ Sbjct: 67 CVTGSADYSIKLWDVSNGQCVAT------WKSP---VPVKRVEFSPCGNYFLA-ILDNVM 116 Query: 214 K------IWDCIGGCVVRTF---QVQPLEKGVLHHSCGMDFLNPEDGST--PLVISGYEN 262 K I++ +P+ K + H G+D ST +I+G+++ Sbjct: 117 KNPGSINIYEIERDSATHELTKVSEEPIHKIITHE--GLDAATVAGWSTKGKYIIAGHKD 174 Query: 263 GDI 265 G I Sbjct: 175 GKI 177 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 1/84 (1%) Query: 51 VTSHARPFSELCWSPDGQCIATASDDFSVEIIH-LSYGLLHTFIGHTAPVISLTFNRKGN 109 +T H RP +++ ++ +G + + S D S + + L+ L T GHT + S+ + Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTK 65 Query: 110 LLFTSSMDESIKIWDTLNGSLMKT 133 T S D SIK+WD NG + T Sbjct: 66 YCVTGSADYSIKLWDVSNGQCVAT 89 >6MZM-G nrPDB Length = 800 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 98/222 (44%), Gaps = 20/222 (9%) Query: 50 LVTSHARPFSELCWSPDGQCIATASDDFSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKG 108 ++ H+ P +SPD + ++S+D +V + L ++ L + GH PV F+ G Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG 597 Query: 109 NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 + D ++W T + ++ + H V N S+ +++GS D +R++D Sbjct: 598 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN-SNYVATGSADRTVRLWDV 656 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 G+C++ T K PI + FS N R+L + DG V +WD G +V Sbjct: 657 LNGNCVRIFTGHKG--------PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL- 707 Query: 229 VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 KG C + F DG ++ SG + + W++ Sbjct: 708 -----KGHTDTVCSLRF--SRDGE--ILASGSMDNTVRLWDA 740 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 43/167 (25%), Positives = 73/167 (43%), Gaps = 10/167 (5%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHLS-YGLLHTFIGHTAPVISLTFNRKGNLLF 112 H P + +SP G + D + Y L F GH A V F+ N + Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643 Query: 113 TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 T S D ++++WD LNG+ ++ + H + S+ N L++G+ DG + ++D G Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN-GRFLATGATDGRVLLWDIGHGL 702 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI 219 + L D + ++FS + L S+D V++WD I Sbjct: 703 MVGELKGHTDT--------VCSLRFSRDGEILASGSMDNTVRLWDAI 741 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 38/140 (27%), Positives = 70/140 (50%), Gaps = 5/140 (3%) Query: 18 CAKISPDGQFLAI-TQGLNILIYDI-NRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 C + P+ ++A + + ++D+ N V + T H P L +SP+G+ +AT + Sbjct: 632 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVR--IFTGHKGPIHSLTFSPNGRFLATGAT 689 Query: 76 DFSVEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 134 D V + + +GL+ GHT V SL F+R G +L + SMD ++++WD + Sbjct: 690 DGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET 749 Query: 135 SAHSEAVVSVDVPMNDSSIL 154 + A +++P N +L Sbjct: 750 DDFTTATGHINLPENSQELL 769 Score = 48.1 bits (113), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 48/221 (21%), Positives = 90/221 (40%), Gaps = 25/221 (11%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 GH+ PV +F+ N L +SS D ++++W + + H+ V Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600 Query: 154 LSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVV 213 + SG +D + R++ + L+ + ++ +F N+ Y+ S D V Sbjct: 601 V-SGGHDRVARLWATDHYQPLRIFA--------GHLADVNCTRFHPNSNYVATGSADRTV 651 Query: 214 KIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTK 273 ++WD + G VR F KG +H +P + + +G +G + W+ Sbjct: 652 RLWDVLNGNCVRIFTGH---KGPIHSLT----FSP---NGRFLATGATDGRVLLWDIGHG 701 Query: 274 SLLQLLDGSLYHHSSPVMSIHCF--GNIMCSLALNGDCCLW 312 L+ G L H+ V S+ G I+ S +++ LW Sbjct: 702 ----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738 Score = 32.0 bits (71), Expect = 0.32, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 53/121 (43%), Gaps = 30/121 (24%) Query: 21 ISPDGQFLAI--TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS---- 74 SP+G+FLA T G +L++DI + L H L +S DG+ +A+ S Sbjct: 677 FSPNGRFLATGATDG-RVLLWDIGHGLMVGEL-KGHTDTVCSLRFSRDGEILASGSMDNT 734 Query: 75 ---------------DDFSVEIIHLSYG------LLHTFIGHTAPVISLTFNRKGNLLFT 113 DDF+ H++ LL T++ + PV+ L F R+ NL+ Sbjct: 735 VRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRR-NLVLA 793 Query: 114 S 114 + Sbjct: 794 A 794 >5Z56-q nrPDB Length = 504 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 83/206 (40%), Gaps = 37/206 (17%) Query: 60 ELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDES 119 +LC S + + +D V S +L T GHT V S+ F+ +L+F++S D + Sbjct: 228 DLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDAT 287 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY 179 I+IW N S ++ + AH AV + + +LSS S D D +TG L +T Sbjct: 288 IRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSS-SDDQYWAFSDIQTGRVLTKVTD 346 Query: 180 DK-----------------------------DWKRENGVV-------PISQVKFSENARY 203 + D K V PI+ + FSEN Y Sbjct: 347 ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYY 406 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQV 229 L + D VK+WD +T Q+ Sbjct: 407 LATAADDSSVKLWDLRKLKNFKTLQL 432 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 8/116 (6%) Query: 12 NGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI 70 +G TCA+ PDG T I I+D+ RT H+ P + + +S +G + Sbjct: 349 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF-PGHSGPITSIAFSENGYYL 407 Query: 71 ATASDDFSVEIIHLSYGLLHTF----IGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 ATA+DD SV++ L L F + + V SL F++ G L D I I Sbjct: 408 ATAADDSSVKLWDLRK--LKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI 461 >4LG8-A nrPDB Length = 354 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 83/206 (40%), Gaps = 37/206 (17%) Query: 60 ELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDES 119 +LC S + + +D V S +L T GHT V S+ F+ +L+F++S D + Sbjct: 78 DLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDAT 137 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY 179 I+IW N S ++ + AH AV + + +LSS S D D +TG L +T Sbjct: 138 IRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSS-SDDQYWAFSDIQTGRVLTKVTD 196 Query: 180 DK-----------------------------DWKRENGVV-------PISQVKFSENARY 203 + D K V PI+ + FSEN Y Sbjct: 197 ETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYY 256 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQV 229 L + D VK+WD +T Q+ Sbjct: 257 LATAADDSSVKLWDLRKLKNFKTLQL 282 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 8/116 (6%) Query: 12 NGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI 70 +G TCA+ PDG T I I+D+ RT H+ P + + +S +G + Sbjct: 199 SGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF-PGHSGPITSIAFSENGYYL 257 Query: 71 ATASDDFSVEIIHLSYGLLHTF----IGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 ATA+DD SV++ L L F + + V SL F++ G L D I I Sbjct: 258 ATAADDSSVKLWDLRK--LKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI 311 >5OPT-p nrPDB Length = 318 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 63/259 (24%), Positives = 116/259 (44%), Gaps = 42/259 (16%) Query: 48 QTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNR 106 + + H+ S++ S +G +AS D S+ + +L G+ H F+GHT V+S+TF+ Sbjct: 60 ERRLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSP 119 Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKTI--SAHSEAVVSVDV-PMNDSSILSSGSYDGLI 163 + + D ++++W+ + G + T+ AH++ V V P ++ ++ SG +D L+ Sbjct: 120 DNRQIVSGGRDNALRVWN-VKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLV 178 Query: 164 RIFDAETGHCLKTL--------------------TYDKD-----WKRENGV--------V 190 +++D +G L L + DKD W G Sbjct: 179 KVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGA 238 Query: 191 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 PI+Q+ FS N RY + + + ++I+D V+ + +K C M D Sbjct: 239 PINQICFSPN-RYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPEC-MSIAWSAD 296 Query: 251 GSTPLVISGYENGDIYCWN 269 G+T + SGY + I W+ Sbjct: 297 GNT--LYSGYTDNVIRVWS 313 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 44/182 (24%), Positives = 78/182 (42%), Gaps = 20/182 (10%) Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCL-KTLTYDKDWKRENGVV 190 + + HS V V + N+ S S+D +R+++ +TG C K L + KD Sbjct: 61 RRLEGHSAFVSDVALS-NNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKD-------- 111 Query: 191 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 + V FS + R ++ D +++W+ G C + L +G +P Sbjct: 112 -VLSVTFSPDNRQIVSGGRDNALRVWNVKGEC------LHTLGRGAHTDWVSCVRFSPS- 163 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 TPL++SG + + W+ + LL L G + +S +S G++ S +G Sbjct: 164 LETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPD--GSLCASSDKDGVAR 221 Query: 311 LW 312 LW Sbjct: 222 LW 223 >4V7E-Bg nrPDB Length = 380 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 6/129 (4%) Query: 94 GHTAPVISLTFNR-KGNLLFTSSMDESIKIWD-TLNGSLMKTISAHSEAVVSVDVPMNDS 151 GHTA V+SL+ N N+ + S D ++++WD + ++T H + SV D Sbjct: 203 GHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKF-FPDG 261 Query: 152 SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI-SQVKFSENARYLLVKSLD 210 +GS DG R+FD TGH L+ Y+++ R + +PI + V FS + R L + Sbjct: 262 QRFGTGSDDGTCRLFDMRTGHQLQ--VYNREPDRNDNELPIVTSVAFSISGRLLFAGYSN 319 Query: 211 GVVKIWDCI 219 G +WD + Sbjct: 320 GDCYVWDTL 328 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/161 (25%), Positives = 73/161 (45%), Gaps = 20/161 (12%) Query: 27 FLAITQGLNILIYDINRRTVSQTLVTSHARP--FSELCWSPDGQCIATASDDFSVEIIHL 84 F++ + + ++D+ R S+ + T H + + + PDGQ T SDD + + + Sbjct: 221 FISGSCDTTVRLWDL--RITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDM 278 Query: 85 SYGLLHTF-IGHTAP---------VISLTFNRKGNLLFTSSMDESIKIWDTLNGSL---M 131 G H + + P V S+ F+ G LLF + +WDTL + + Sbjct: 279 RTG--HQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNL 336 Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 T+ E +S +D S L +GS+D ++I+ A +GH Sbjct: 337 GTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW-AFSGH 376 Score = 34.7 bits (78), Expect = 0.049, Method: Compositional matrix adjust. Identities = 34/150 (22%), Positives = 59/150 (39%), Gaps = 25/150 (16%) Query: 90 HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN 149 T GH+ V SL + + N + ++S D + +W+ L I H V+ N Sbjct: 60 RTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPN 119 Query: 150 DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV-----KFSENARY- 203 S+ + G D IF+ + D+D G +P+S+V ++ + +Y Sbjct: 120 GQSV-ACGGLDSACSIFNLSS-------QADRD-----GNMPVSRVLTGHKGYASSCQYV 166 Query: 204 ------LLVKSLDGVVKIWDCIGGCVVRTF 227 L+ S D +WD G + F Sbjct: 167 PDQETRLITGSGDQTCVLWDVTTGQRISIF 196 >4V8M-A7 nrPDB Length = 318 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/187 (28%), Positives = 89/187 (47%), Gaps = 25/187 (13%) Query: 47 SQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFI-GHTAPVISLTFN 105 + T V S +R + L W P+ D S E SYGL + GH+A V + + Sbjct: 27 TATKVVSTSRDKTLLSWGPN-------PDRHSSEC---SYGLPDRRLEGHSAFVSDVALS 76 Query: 106 RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRI 165 GN ++S D S+++W+ NG H++ V+SV ++ I+S G D +R+ Sbjct: 77 NNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGR-DNALRV 135 Query: 166 FDAETGHCLKTLTYDK--DWKRENGVVPISQVKFSE--NARYLLVKSLDGVVKIWDCIGG 221 ++ + G C+ TL+ DW +S V+FS +A ++ D +VK+WD G Sbjct: 136 WNVK-GECMHTLSRGAHTDW--------VSCVRFSPSLDAPVIVSGGWDNLVKVWDLATG 186 Query: 222 CVVRTFQ 228 +V + Sbjct: 187 RLVTDLK 193 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 94/219 (42%), Gaps = 18/219 (8%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFI--GHTAPVISLTFNRK--GN 109 H + + +SPD + I + D ++ + ++ +HT HT V + F+ Sbjct: 108 HTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAP 167 Query: 110 LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 ++ + D +K+WD G L+ + H+ V SV V D S+ +S DG+ R++D Sbjct: 168 VIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSP-DGSLCASSDKDGVARLWDLT 226 Query: 170 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQV 229 G L + PI+Q+ FS N RY + + + ++I+D ++ Sbjct: 227 KGEALSEMAAG---------APINQICFSPN-RYWMCAATEKGIRIFDLENKDIIVELAP 276 Query: 230 QPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 + + C + DGST + SGY + I W Sbjct: 277 EHQGSKKIVPEC-VSIAWSADGST--LYSGYTDNVIRVW 312 Score = 31.6 bits (70), Expect = 0.47, Method: Compositional matrix adjust. Identities = 27/125 (21%), Positives = 54/125 (43%), Gaps = 9/125 (7%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKG 108 T + H + + SPDG A++ D + L+ G + + AP+ + F+ Sbjct: 190 TDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFS-PN 248 Query: 109 NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPM-------NDSSILSSGSYDG 161 ++ ++ I+I+D N ++ ++ + + VP D S L SG D Sbjct: 249 RYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKI-VPECVSIAWSADGSTLYSGYTDN 307 Query: 162 LIRIF 166 +IR++ Sbjct: 308 VIRVW 312 >6HQA-B nrPDB Length = 722 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 97/216 (44%), Gaps = 15/216 (6%) Query: 21 ISPDGQFL-AITQGLNILIYDINRRTVSQTLVT--SHARPFSELCWSPDGQCIATASDDF 77 SPD ++L + ++ + ++ ++ T LV+ H+ ++ +SP G ATAS D Sbjct: 461 FSPDNRYLISCSEDKTVRLWSLDTYTC---LVSYKGHSSSVWDVKFSPMGHYFATASHDQ 517 Query: 78 SVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA 136 + + + L F GH V + F+ LFT S D++ ++WD G ++ Sbjct: 518 TARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMG 577 Query: 137 HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK 196 HS A+ + V D L+S D ++ ++D TG +K + R +G I + Sbjct: 578 HSGAINCLAV-SPDGRWLASAGEDSVVCLWDISTGRRIKAM-------RGHGRSSIYSLA 629 Query: 197 FSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 232 FS L+ D V++WD + Q +P+ Sbjct: 630 FSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEPI 665 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 31/137 (22%), Positives = 59/137 (43%), Gaps = 11/137 (8%) Query: 92 FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDV-PMND 150 +GH+ V + F+ L + S D+++++W + + + HS +V V PM Sbjct: 449 LVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM-- 506 Query: 151 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLD 210 ++ S+D R++ + + L+ + + V+F N+ YL S D Sbjct: 507 GHYFATASHDQTARLWSCDHIYPLRIFA--------GHLNDVDCVEFHPNSTYLFTGSSD 558 Query: 211 GVVKIWDCIGGCVVRTF 227 ++WD G VR F Sbjct: 559 KTARMWDIARGECVRVF 575 Score = 34.3 bits (77), Expect = 0.076, Method: Compositional matrix adjust. Identities = 38/161 (23%), Positives = 64/161 (39%), Gaps = 32/161 (19%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT--------------- 133 ++TF + L FN ++ + D IK+W +++GS +++ Sbjct: 383 MYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLW-SIDGSPLRSLLKNDPYNQQNNDGV 441 Query: 134 -------ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 186 + HS AV VD D+ L S S D +R++ +T CL ++Y + Sbjct: 442 AVKGSRRLVGHSGAVYGVDF-SPDNRYLISCSEDKTVRLWSLDTYTCL--VSY------K 492 Query: 187 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 + VKFS Y S D ++W C +R F Sbjct: 493 GHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIF 533 >5GAN-H nrPDB Length = 465 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 67/265 (25%), Positives = 108/265 (40%), Gaps = 33/265 (12%) Query: 47 SQTL------VTSHARPFSELCWSPD--GQCIATASD----DFSVEIIHLSYGLLHTFIG 94 SQTL + SH + W PD Q I+ A D +F LL +G Sbjct: 204 SQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVG 263 Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSIL 154 H + + ++ G + ++S D + ++WD + H + V S+ D S++ Sbjct: 264 HERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQC-DGSLV 322 Query: 155 SSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVK 214 SG D L ++D +G + TL PI V +S N + DG++ Sbjct: 323 CSGGMDSLSMLWDIRSGSKVMTLAGHSK--------PIYTVAWSPNGYQVATGGGDGIIN 374 Query: 215 IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF-LNPEDGSTPLVISGYENGDIYCWNSDTK 273 +WD +R L + + H + + EDG LV GY+N I ++SDT Sbjct: 375 VWD------IRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNL-INVYSSDT- 426 Query: 274 SLLQLLDGSLYHHSSPVMSIHCFGN 298 L GSL H+ ++S+ N Sbjct: 427 ---WLKMGSLAGHTDKIISLDISNN 448 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 34/136 (25%), Positives = 70/136 (51%), Gaps = 7/136 (5%) Query: 37 LIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSV---EIIHLSYGLLHTFI 93 +++DI + TL H++P + WSP+G +AT D + +I G L+ + Sbjct: 332 MLWDIRSGSKVMTLA-GHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQIL 390 Query: 94 GHTAPVISLTFNRK--GNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS 151 H V + F+++ G L + D I ++ + M +++ H++ ++S+D+ N+S Sbjct: 391 AHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDIS-NNS 449 Query: 152 SILSSGSYDGLIRIFD 167 L SG +D I++++ Sbjct: 450 HFLVSGGWDRSIKLWN 465 Score = 33.9 bits (76), Expect = 0.094, Method: Compositional matrix adjust. Identities = 27/108 (25%), Positives = 53/108 (49%), Gaps = 5/108 (4%) Query: 22 SPDGQFLAITQGLNIL-IYDINRRTVSQ-TLVTSHARPFSELCWSPD--GQCIATASDDF 77 SP+G +A G I+ ++DI +R Q + +H +++ +S + G+ + + D Sbjct: 358 SPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDN 417 Query: 78 SVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 + + L + + GHT +ISL + + L + D SIK+W+ Sbjct: 418 LINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 >6EMK-B nrPDB Length = 303 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 97/208 (46%), Gaps = 30/208 (14%) Query: 110 LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 +L ++ D +I+ W+ L G +TI HS++ V+ ND +L++ + +R++D Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKKLLATAGHQN-VRLYDIR 61 Query: 170 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQV 229 T + +++ R N ++ V F ++ R+++ S DG +K+WD + R ++ Sbjct: 62 TTNPNPVASFEG--HRGN----VTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH 115 Query: 230 Q-PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW----NSDTKSLLQLLDGSLY 284 P+ + V+H P G +IS +G+I W N T L D SL Sbjct: 116 NAPVNEVVIH---------PNQGE---LISCDRDGNIRIWDLGENQCTHQLTPEDDTSL- 162 Query: 285 HHSSPVMSIHCFGNIMCSLALNGDCCLW 312 +S+ G+++ + G+C +W Sbjct: 163 ----QSLSMASDGSMLAAANTKGNCYVW 186 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 2/92 (2%) Query: 91 TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMND 150 +F GH V S++F + + TSS D +IK+WD + S+ + H+ V V + N Sbjct: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQ 128 Query: 151 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 ++S DG IRI+D C LT + D Sbjct: 129 GELISCDR-DGNIRIWDLGENQCTHQLTPEDD 159 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 49/252 (19%), Positives = 95/252 (37%), Gaps = 46/252 (18%) Query: 20 KISPDGQFLAITQGLNILIYDINRRTVSQTLVTS---HARPFSELCWSPDGQCIATASDD 76 +I+ D + LA N+ +YDI RT + V S H + + + D + + T+S+D Sbjct: 39 EITNDKKLLATAGHQNVRLYDI--RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED 96 Query: 77 FSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA 136 ++++ + + H APV + + L + D +I+IWD ++ Sbjct: 97 GTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTP 156 Query: 137 HSEAVVSVDVPMNDSSILSSGSYDG----------------------------LIRIF-- 166 + + +D S+L++ + G + RI Sbjct: 157 EDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS 216 Query: 167 -------DAETGHCLKTLTYDKDWKRENGVVP----ISQVKFSENARYLLVKSLDGVVKI 215 H + + D D+K E + + FS ++ YL+ S D V++ Sbjct: 217 SDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 Query: 216 WDCIGGCVVRTF 227 WD +VR + Sbjct: 277 WDLSTREIVRQY 288 Score = 35.8 bits (81), Expect = 0.024, Method: Compositional matrix adjust. Identities = 34/139 (24%), Positives = 61/139 (43%), Gaps = 12/139 (8%) Query: 21 ISPDGQFLAI--TQGLNILIYDINRRTVSQ-----TLVTSHARPFSELCWSPDGQCIATA 73 ++ DG LA T+G N ++++ T + T +H+ + + S D + +AT Sbjct: 167 MASDGSMLAAANTKG-NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 Query: 74 SDDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 131 S D + + I + L T GH V F+ L T+S D +++WD ++ Sbjct: 226 SADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 Query: 132 KTISAHSEAVVSVDVPMND 150 + H + V V +ND Sbjct: 286 RQYGGHHKGAVC--VALND 302 >3DM0-A nrPDB Length = 694 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 71/291 (24%), Positives = 113/291 (38%), Gaps = 72/291 (24%) Query: 37 LIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGH 95 L D V+Q +T H+ ++ S DGQ + S D + + L+ G+ F+GH Sbjct: 412 LTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGH 471 Query: 96 TAPVISLTFNRKGNLLFTSSMDESIKIWDTL----------------------------- 126 T V+S+ F+ + ++S D +IK+W+TL Sbjct: 472 TKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQ 531 Query: 127 ------------------NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 N L T++ H+ V +V V D S+ +SG DG++ ++D Sbjct: 532 PTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSP-DGSLCASGGKDGVVLLWDL 590 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 G L +L N V I + FS N RY L + + +KIWD +V + Sbjct: 591 AEGKKLYSL-------EANSV--IHALCFSPN-RYWLCAATEHGIKIWDLESKSIVEDLK 640 Query: 229 VQPLEKGVLHHSCGMDFLNPE-----------DGSTPLVISGYENGDIYCW 268 V + + G + DGST + SGY +G I W Sbjct: 641 VDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGST--LFSGYTDGVIRVW 689 >6Q8F-A nrPDB Length = 514 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 73/315 (23%), Positives = 139/315 (44%), Gaps = 40/315 (12%) Query: 18 CAKISPDGQFLAITQGLN--ILIYDINRRTVSQTLVTSHARPFSEL-------CWSPDGQ 68 CA+ SPDGQ+L +T ++ I +++ + + L F + C+S D + Sbjct: 220 CARFSPDGQYL-VTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTE 278 Query: 69 CIATASDDFSVEIIHLSYG--LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL 126 +AT + D +++ + G L H+ V L+F++ + + ++S D++I+I Sbjct: 279 MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLK 338 Query: 127 NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 186 +G +K HS V + I+S+ S DG ++I++ +T C T K Sbjct: 339 SGKTLKEFRGHSSFVNEATFTQDGHYIISASS-DGTVKIWNMKTTECSNTF---KSLGST 394 Query: 187 NG--VVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD 244 G + S + +N + +V + V I + + G +VR+F E G D Sbjct: 395 AGTDITVNSVILLPKNPEHFVVCNRSNTVVIMN-MQGQIVRSFSSGKREGG--------D 445 Query: 245 F----LNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI--HCFGN 298 F L+P + E+ +YC+++ T L+ +L H V+ I H N Sbjct: 446 FVCCALSPRG---EWIYCVGEDFVLYCFSTVTGK----LERTLTVHEKDVIGIAHHPHQN 498 Query: 299 IMCSLALNGDCCLWR 313 ++ + + +G LW+ Sbjct: 499 LIATYSEDGLLKLWK 513 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/190 (23%), Positives = 83/190 (43%), Gaps = 24/190 (12%) Query: 90 HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS--AHSEAVVSVDVP 147 H G + V F+ G L T S+D I++W+ G + K + A ++ D Sbjct: 209 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 268 Query: 148 M-----NDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR 202 + D+ +L++G+ DG I+++ ++G CL+ + GV +S FS+++ Sbjct: 269 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRF----ERAHSKGVTCLS---FSKDSS 321 Query: 203 YLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN 262 +L S D ++I G ++ F+ H S + +DG +IS + Sbjct: 322 QILSASFDQTIRIHGLKSGKTLKEFRG--------HSSFVNEATFTQDGH--YIISASSD 371 Query: 263 GDIYCWNSDT 272 G + WN T Sbjct: 372 GTVKIWNMKT 381 >6G51-g nrPDB Length = 317 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 70/275 (25%), Positives = 120/275 (43%), Gaps = 47/275 (17%) Query: 1 MFQFVTPVGTQNGLKATCAKISPDGQF----LAITQGLNILIYDINRRT----VSQTLVT 52 M + +T GT G +I+ QF L+ ++ I+++ + R + Q + Sbjct: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 Query: 53 SHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLL 111 H+ S++ S DGQ + S D ++ + L+ G F+GHT V+S+ F+ + Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 Query: 112 FTSSMDESIKIWDTLNGSLMKTI--SAHSEAVVSVDVPMNDSS-ILSSGSYDGLIRIFDA 168 + S D++IK+W+TL G T+ +HSE V V N S+ I+ S +D L+++++ Sbjct: 121 VSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 Query: 169 ET--------GHC--LKTLTYDKD---------------WKRE--------NGVVPISQV 195 GH L T+T D W +G I+ + Sbjct: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINAL 239 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ 230 FS N RY L + +KIWD G +V + + Sbjct: 240 CFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQE 273 Score = 28.9 bits (63), Expect = 2.7, Method: Compositional matrix adjust. Identities = 20/75 (26%), Positives = 33/75 (44%), Gaps = 8/75 (10%) Query: 21 ISPDGQFLAITQGLNILIYDINRRTVSQTL------VTSHARP--FSELCWSPDGQCIAT 72 SP+ +L G +I I+D+ + + L +S A P + L WS DGQ + Sbjct: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 Query: 73 ASDDFSVEIIHLSYG 87 D V + ++ G Sbjct: 301 GYTDNLVRVWQVTIG 315 >5FL8-q nrPDB Length = 515 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 49/156 (31%), Positives = 77/156 (49%), Gaps = 13/156 (8%) Query: 38 IYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG--LLHTFIGH 95 I+D + +T TL H + WSPDG+ IAT S D ++ + G L GH Sbjct: 170 IWDCDTQTPMHTL-KGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGH 228 Query: 96 TAPVISLTFN-----RKGN--LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPM 148 + + SL++ + G+ L +SS D +IKIWDT++ T+S H+ +V V Sbjct: 229 SKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVK--W 286 Query: 149 NDSSILSSGSYDGLIRIFDAET-GHCLKTLTYDKDW 183 +L SGS+D +R++D + G C+ L W Sbjct: 287 GGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHW 322 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 36/132 (27%), Positives = 68/132 (51%), Gaps = 2/132 (1%) Query: 36 ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIG 94 + +++ + T +T H + + + +SPDG+ I +AS D S+++ G + TF G Sbjct: 383 MFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRG 442 Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSIL 154 H A V + ++ LL + S D ++K+WD L + H + V +VD + D + Sbjct: 443 HVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSV-DGKRV 501 Query: 155 SSGSYDGLIRIF 166 SG D ++R++ Sbjct: 502 CSGGKDKMVRLW 513 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 38/128 (29%), Positives = 59/128 (46%), Gaps = 4/128 (3%) Query: 94 GHTAPVISLTFN-RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSS 152 GH + ++ F + + T + D + +IWD + M T+ H V+ V D Sbjct: 141 GHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSW-SPDGE 199 Query: 153 ILSSGSYDGLIRIFDAETGHCL-KTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG 211 ++++GS D IR++D ++G CL L W PI VK R L S DG Sbjct: 200 VIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPR-LASSSKDG 258 Query: 212 VVKIWDCI 219 +KIWD + Sbjct: 259 TIKIWDTV 266 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/252 (22%), Positives = 102/252 (40%), Gaps = 42/252 (16%) Query: 18 CAKISPDGQFLAITQGLN-ILIYDINRRTVSQTLVTSHARPFSELCWSP-------DGQC 69 C SPDG+ +A N I ++D + H++ + L W P Sbjct: 191 CVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPR 250 Query: 70 IATASDDFSVEIIH-LSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD-TLN 127 +A++S D +++I +S +T GHT V + + +G LL++ S D ++++WD Sbjct: 251 LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQ 309 Query: 128 GSLMKTISAHSEAV----VSVDVPMNDSSILSSGSY-----DGLIRIFDAETGHCLKT-- 176 G + + +H+ V +S D + + +G + + + C K Sbjct: 310 GRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGN 369 Query: 177 -----LTYDKD-----WKRENGVVPISQ----------VKFSENARYLLVKSLDGVVKIW 216 +T D W PI++ V FS + RY++ S D +K+W Sbjct: 370 SEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLW 429 Query: 217 DCIGGCVVRTFQ 228 D G + TF+ Sbjct: 430 DGRDGKFISTFR 441 Score = 48.1 bits (113), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 38/136 (27%), Positives = 65/136 (47%), Gaps = 16/136 (11%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS-LMKTISAHSEAVVSVD-- 145 +HT GH V+ ++++ G ++ T SMD +I++WD +G L + HS+ + S+ Sbjct: 179 MHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWE 238 Query: 146 ----VPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA 201 V L+S S DG I+I+D + C T++ + +S VK+ Sbjct: 239 PIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTN--------SVSCVKWGGQG 290 Query: 202 RYLLVKSLDGVVKIWD 217 L S D V++WD Sbjct: 291 -LLYSGSHDRTVRVWD 305 >3JB9-L nrPDB Length = 340 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 37/160 (23%), Positives = 78/160 (48%), Gaps = 17/160 (10%) Query: 63 WSPDGQCIATASDDFSVEIIHL-----SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMD 117 + P G A+ D + + ++ +YG+L+ G + L ++R +++ SS D Sbjct: 58 FDPSGSYFASGGMDRQILLWNVFGDVKNYGVLN---GCKGAITDLQWSRDSRVVYCSSSD 114 Query: 118 ESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTL 177 + WD ++G ++ H+ V ++DV S +L+S S D ++++D+ + C+KT+ Sbjct: 115 THLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTI 174 Query: 178 TYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWD 217 P++ V ++ + + +DG +KIWD Sbjct: 175 EEK---------YPLTAVAIAQQGTQVFIGGIDGAIKIWD 205 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 16/157 (10%) Query: 98 PVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSG 157 P+ ++ ++G +F +D +IKIWD N + H + + S+ + + SS+LS+ Sbjct: 179 PLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSN- 237 Query: 158 SYDGLIRIFD----AETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVV 213 S D +RIFD A L+ + N + V +S N+R++ S D V Sbjct: 238 SMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHN----LLGVAWSRNSRFVGAGSSDKNV 293 Query: 214 KIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 +W G V P +G ++H +DF +D Sbjct: 294 YVWSATGDLRY----VLPGHEGSVNH---VDFHPHQD 323 >5NZU-C nrPDB Length = 905 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 46/156 (29%), Positives = 71/156 (45%), Gaps = 12/156 (7%) Query: 65 PDGQCIATASDDFSVEIIH--LSYGLLHTFIGHTAPVISLTFNRKGNLLFTS-SMDESIK 121 P I T+SDD +++ + F GHT V+ + N K N F S S+D +IK Sbjct: 109 PTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIK 168 Query: 122 IWDTLNGSLMKTISAHSEAVVSVD-VPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYD 180 +W + S T+ H + V +D D L SG+ D L++I+D + C++TL Sbjct: 169 VWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTL--- 225 Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW 216 E +S F ++ S DG V+IW Sbjct: 226 -----EGHAQNVSCASFHPELPIIITGSEDGTVRIW 256 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 94/213 (44%), Gaps = 18/213 (8%) Query: 70 IATASDDFSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD-TLN 127 + T +DD + + + + +H F H+ + + + + TSS D IK+WD Sbjct: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK 131 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN 187 S + H+ V+ + + D++ +S S D I+++ + G T + E Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVW--QLGSSSPNFTLEG---HEK 186 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLN 247 GV I + YL+ + D +VKIWD V+T LE + SC + Sbjct: 187 GVNCIDYYSGGDKP-YLISGADDRLVKIWDYQNKTCVQT-----LEGHAQNVSCAS--FH 238 Query: 248 PEDGSTPLVISGYENGDIYCWNSDTKSLLQLLD 280 PE P++I+G E+G + W+S T L L+ Sbjct: 239 PE---LPIIITGSEDGTVRIWHSSTYRLESTLN 268 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 104/243 (42%), Gaps = 43/243 (17%) Query: 83 HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVV 142 H + L+ TF PV + F + N + T + D I++++ + AHS+ + Sbjct: 44 HETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIR 103 Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR 202 + V IL+S S D LI+++D +DK W SQV F + Sbjct: 104 CIAVHPTQPFILTS-SDDMLIKLWD-----------WDKKWS-------CSQV-FEGHTH 143 Query: 203 YLLV-------------KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPE 249 Y++ SLD +K+W G F ++ EKGV +C +D+ + Sbjct: 144 YVMQIVINPKDNNQFASASLDRTIKVWQL--GSSSPNFTLEGHEKGV---NC-IDYYS-- 195 Query: 250 DGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDC 309 G P +ISG ++ + W+ K+ +Q L+G + + S H I+ + + +G Sbjct: 196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEG--HAQNVSCASFHPELPIIITGSEDGTV 253 Query: 310 CLW 312 +W Sbjct: 254 RIW 256 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 41/167 (24%), Positives = 76/167 (45%), Gaps = 6/167 (3%) Query: 18 CAKISPDGQF-LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP-DGQCIATASD 75 C + P F L + + I ++D +++ + H ++ +P D A+AS Sbjct: 104 CIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASL 163 Query: 76 DFSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGN--LLFTSSMDESIKIWDTLNGSLMK 132 D ++++ L S T GH V + + G+ L + + D +KIWD N + ++ Sbjct: 164 DRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQ 223 Query: 133 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY 179 T+ H++ V + I+ +GS DG +RI+ + T TL Y Sbjct: 224 TLEGHAQNVSCASF-HPELPIIITGSEDGTVRIWHSSTYRLESTLNY 269 >6QDV-o nrPDB Length = 513 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 46/153 (30%), Positives = 75/153 (49%), Gaps = 15/153 (9%) Query: 80 EIIHLSYGLLHTFIGHTAPVISLT-FNRKGNLLFTSSMDESIKIWDTLNGSL-MKTISAH 137 E +L +H + GHT V ++ F G+LL + SMD IK+W+ ++T H Sbjct: 206 EKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGH 265 Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 S+AV + + LS+ +YD ++++D ETG C+ T N VP VKF Sbjct: 266 SKAVRDICFNTAGTQFLSA-AYDRYLKLWDTETGQCISRFT--------NRKVPYC-VKF 315 Query: 198 S--ENARYLLVKSL-DGVVKIWDCIGGCVVRTF 227 + E+ + L V + D + WD G +V+ + Sbjct: 316 NPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEY 348 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/130 (23%), Positives = 57/130 (43%), Gaps = 9/130 (6%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHS-EAVVSVDVP 147 L TFIGH+ V + FN G +++ D +K+WDT G + + V + Sbjct: 259 LRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPD 318 Query: 148 MNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK 207 + ++ +G D I +D +G ++ YD+ N +V F + R + Sbjct: 319 EDKQNLFVAGMSDKKIVQWDIRSGEIVQ--EYDRHLGAVNTIV------FVDENRRFVST 370 Query: 208 SLDGVVKIWD 217 S D +++W+ Sbjct: 371 SDDKSLRVWE 380 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 48/111 (43%), Gaps = 8/111 (7%) Query: 64 SPDGQCIATASDDFSVEII----HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDES 119 SP+G+ +A S D + I F GH + + ++ + S D + Sbjct: 404 SPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGN 463 Query: 120 IK--IWDTLNGSLMKTISAHSEAVV-SVDVPMNDSSILSSGSYDGLIRIFD 167 K IWD L AH + + +V P S +++ G +DGLI+++D Sbjct: 464 GKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCG-WDGLIKLWD 513 >5K0Y-T nrPDB Length = 329 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 30/84 (35%), Positives = 47/84 (55%), Gaps = 1/84 (1%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 GH + + +NR+G+LLFT + D + +W ++NG + T H+ AV VD + + Sbjct: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHV 67 Query: 154 LSSGSYDGLIRIFDAETGHCLKTL 177 L +GS D R++D ETG L L Sbjct: 68 L-TGSADNSCRLWDCETGKQLALL 90 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 50/234 (21%), Positives = 90/234 (38%), Gaps = 60/234 (25%) Query: 50 LVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKG 108 L+ H R +++ ++ +G + T + D V + + G L T++GHT V + + Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 109 NLLFTSSMDESIKIWDTLNG---SLMKTISA---------------------HSEAVVS- 143 + T S D S ++WD G +L+KT SA + VS Sbjct: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSF 124 Query: 144 ---------------VDVPMNDSSILS-----------SGSYDGLIRIFDAETGHCLKTL 177 + +P NDS I S +G G + + A++G L + Sbjct: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV 184 Query: 178 TYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQP 231 K+ R+ I+ ++ S + S D K++D +TF+ +P Sbjct: 185 ---KEHSRQ-----INDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEP 230 >5YZG-W nrPDB Length = 579 Score = 57.0 bits (136), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 46/153 (30%), Positives = 75/153 (49%), Gaps = 15/153 (9%) Query: 80 EIIHLSYGLLHTFIGHTAPVISLT-FNRKGNLLFTSSMDESIKIWDTLNGSL-MKTISAH 137 E +L +H + GHT V ++ F G+LL + SMD IK+W+ ++T H Sbjct: 272 EKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGH 331 Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 S+AV + + LS+ +YD ++++D ETG C+ T N VP VKF Sbjct: 332 SKAVRDICFNTAGTQFLSA-AYDRYLKLWDTETGQCISRFT--------NRKVPYC-VKF 381 Query: 198 S--ENARYLLVKSL-DGVVKIWDCIGGCVVRTF 227 + E+ + L V + D + WD G +V+ + Sbjct: 382 NPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEY 414 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/130 (23%), Positives = 57/130 (43%), Gaps = 9/130 (6%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHS-EAVVSVDVP 147 L TFIGH+ V + FN G +++ D +K+WDT G + + V + Sbjct: 325 LRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPD 384 Query: 148 MNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK 207 + ++ +G D I +D +G ++ YD+ N +V F + R + Sbjct: 385 EDKQNLFVAGMSDKKIVQWDIRSGEIVQ--EYDRHLGAVNTIV------FVDENRRFVST 436 Query: 208 SLDGVVKIWD 217 S D +++W+ Sbjct: 437 SDDKSLRVWE 446 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 48/111 (43%), Gaps = 8/111 (7%) Query: 64 SPDGQCIATASDDFSVEII----HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDES 119 SP+G+ +A S D + I F GH + + ++ + S D + Sbjct: 470 SPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGN 529 Query: 120 IK--IWDTLNGSLMKTISAHSEAVV-SVDVPMNDSSILSSGSYDGLIRIFD 167 K IWD L AH + + +V P S +++ G +DGLI+++D Sbjct: 530 GKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCG-WDGLIKLWD 579 >3FM0-A nrPDB Length = 345 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 88/206 (42%), Gaps = 20/206 (9%) Query: 22 SPDGQFLAITQG---LNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFS 78 +P G LA G + I + + L H R ++ WSP G +A+AS D + Sbjct: 25 NPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDAT 84 Query: 79 VEIIHLS---YGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 I + + + T GH V S+ + GNLL T S D+S+ +W+ + +S Sbjct: 85 TCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVS 144 Query: 136 ---AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH--CLKTLTYDKDWKRENGVV 190 +H++ V V V +L+S SYD ++++ E C TL E Sbjct: 145 VLNSHTQDVKHV-VWHPSQELLASASYDDTVKLYREEEDDWVCCATL--------EGHES 195 Query: 191 PISQVKFSENARYLLVKSLDGVVKIW 216 + + F + + L S D V+IW Sbjct: 196 TVWSLAFDPSGQRLASCSDDRTVRIW 221 >3JAP-g nrPDB Length = 326 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/196 (25%), Positives = 89/196 (45%), Gaps = 14/196 (7%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPM 148 + ++ GH+ V + + GN ++S D+++++W+ G+ H+ V+SV + Sbjct: 59 VRSYKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDA 118 Query: 149 NDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS-QVKFSENARYLLVK 207 N S I+S+ S D IR+++ G C L DW + V P + + ++ R V Sbjct: 119 NSSKIISA-SRDKTIRVWNT-VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVS 176 Query: 208 S-LDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPE-DGSTPLVISGYENGDI 265 + +D +V+ W +E + H+ ++ + P DGS L S ++G I Sbjct: 177 AGMDKIVRSWSL-------NEDSYRIEADFIGHNNYINVVQPSPDGS--LAASAGKDGQI 227 Query: 266 YCWNSDTKSLLQLLDG 281 Y WN KS D Sbjct: 228 YVWNLKHKSAFMNFDA 243 Score = 28.1 bits (61), Expect = 5.9, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 48/117 (41%), Gaps = 11/117 (9%) Query: 22 SPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEI 81 SPDG LA + G + IY N + S + L +SP + TA+ ++I Sbjct: 212 SPDGS-LAASAGKDGQIYVWNLKHKSAFMNFDAKDEVFALAFSP-SRFWLTAATASGIKI 269 Query: 82 IHLSYGLL-----HTFIGHTAP----VISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 L +L F G+T +SL ++ G LF D I++W + + Sbjct: 270 YDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 326 >4J0W-A nrPDB Length = 343 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 25/78 (32%), Positives = 47/78 (60%), Gaps = 1/78 (1%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPM 148 L+TF GH V L F R + L+++S D S+K+W+ S ++T+ H +AV ++D + Sbjct: 102 LYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDA-L 160 Query: 149 NDSSILSSGSYDGLIRIF 166 + +++G DG +R++ Sbjct: 161 SRECCVTAGGRDGTVRVW 178 Score = 31.2 bits (69), Expect = 0.66, Method: Compositional matrix adjust. Identities = 45/232 (19%), Positives = 88/232 (37%), Gaps = 43/232 (18%) Query: 64 SPDGQCIATASDD-----FSVE-------IIHLSYGLLHTFIGHTAPVISLTFNRKGNLL 111 +PD I +A+ D +SVE I G GH++ V+ + + G L Sbjct: 23 TPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYL 82 Query: 112 FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 171 + + I IW+ + + T + H +AV + + S+ S+D +++++ Sbjct: 83 ASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST-SHDRSVKVWNVAEN 141 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQP 231 ++TL +D ++ + + DG V++W P Sbjct: 142 SYVETLFGHQD--------AVAALDALSRECCVTAGGRDGTVRVWKI------------P 181 Query: 232 LEKGVLH--HSCGMD---FLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQL 278 E ++ H +D +N E ++SG ++G + W K L L Sbjct: 182 EESQLVFYGHQGSIDCIHLINEEH-----MVSGADDGSVALWGLSKKRPLAL 228 >5UZ7-B nrPDB Length = 351 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 16/209 (7%) Query: 17 TCAKISPDGQFLAITQGLNIL-IYDINRRT----VSQTLVTSHARPFSELCWSPDGQCIA 71 TCA +P G ++A NI IY++ R VS+ L H S C D I Sbjct: 113 TCA-YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELA-GHTGYLS-CCRFLDDNQIV 169 Query: 72 TASDDFSVEIIHLSYGLLHTFIG-HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL 130 T+S D + + + G T HT V+SL+ L + + D S K+WD G Sbjct: 170 TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 229 Query: 131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV 190 +T + H E+ ++ + + ++GS D R+FD L T ++D N + Sbjct: 230 RQTFTGH-ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHD------NIIC 282 Query: 191 PISQVKFSENARYLLVKSLDGVVKIWDCI 219 I+ V FS++ R LL D +WD + Sbjct: 283 GITSVSFSKSGRLLLAGYDDFNCNVWDAL 311 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 38/81 (46%), Gaps = 1/81 (1%) Query: 90 HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN 149 T GH A + ++ + LL ++S D + IWD+ + + I S V++ + Sbjct: 60 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 119 Query: 150 DSSILSSGSYDGLIRIFDAET 170 + ++ G D + I++ +T Sbjct: 120 -GNYVACGGLDNICSIYNLKT 139 >5Y88-O nrPDB Length = 451 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 40/164 (24%), Positives = 78/164 (47%), Gaps = 12/164 (7%) Query: 66 DGQCIATASDDFSVEIIHLSYGLLHT-FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 D + T S+D ++++ L+ G L T GH V + + + LF+ S D+++K WD Sbjct: 151 DNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWD 210 Query: 125 TLNGSLMKTISAHSEAVVSVDV-PMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDW 183 +++ H V +V + P D ++++ D +I+++D T + TL K Sbjct: 211 LEKNQIIRDYYGHLSGVRTVSIHPTLD--LIATAGRDSVIKLWDMRTRIPVITLVGHKG- 267 Query: 184 KRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 PI+QV+ + ++ S D V++WD + G ++ Sbjct: 268 -------PINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVL 304 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/181 (19%), Positives = 76/181 (41%), Gaps = 2/181 (1%) Query: 36 ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGH 95 I ++D+ R TLV H P +++ +P + ++S D +V + + G + H Sbjct: 248 IKLWDMRTRIPVITLV-GHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTH 306 Query: 96 TAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILS 155 + T S+ + I+ W GSL+ + +++ + +N +L Sbjct: 307 HKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGIINT-LSINQDDVLF 365 Query: 156 SGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 +G +G++ +D ++GH ++L + G + F + L+ D +KI Sbjct: 366 AGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKI 425 Query: 216 W 216 W Sbjct: 426 W 426 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 40/177 (22%), Positives = 78/177 (44%), Gaps = 5/177 (2%) Query: 18 CAKISP--DGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 C I P + F+ + + ++D+ + TL H ++ S + + S+ Sbjct: 144 CVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLA-GHVMTVRDVAVSDRHPYLFSVSE 202 Query: 76 DFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 134 D +V+ L ++ + GH + V +++ + +L+ T+ D IK+WD + T+ Sbjct: 203 DKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITL 262 Query: 135 SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 191 H + V D ++SS S D +R++D G +K LT+ K R + P Sbjct: 263 VGHKGPINQVQCTPVDPQVVSS-STDATVRLWDVVAGKTMKVLTHHKRSVRATALHP 318 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 76/165 (46%), Gaps = 18/165 (10%) Query: 65 PDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 P IATA D +++ + + + T +GH P+ + + +SS D ++++W Sbjct: 234 PTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLW 293 Query: 124 DTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYD---------GLIRIFDAETGHCL 174 D + G MK ++ H +V + + + S+ S+ + D L+ F++E + Sbjct: 294 DVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGII 353 Query: 175 KTLTYDKD----WKRENGVVPI----SQVKFSENARYLLVKSLDG 211 TL+ ++D +NGV+ S K+ A +V SL+G Sbjct: 354 NTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEG 398 >5OQL-J nrPDB Length = 912 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 67/263 (25%), Positives = 101/263 (38%), Gaps = 50/263 (19%) Query: 25 GQFLAITQGLNILIYDIN--RRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII 82 + LA T G N ++ ++N +R + P S L +P G + S ++ I Sbjct: 32 ARILASTLGENAILTELNTGKRLAE---IQGDGEPISTLTITPSGSHLIVCSRSLTMRIY 88 Query: 83 HLSYG---------LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 133 L+ L+ T H PV+ L +R LL T + D +IKIWD + G + T Sbjct: 89 SLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHT 148 Query: 134 ISAHS---------------EAVVSVDVP-------MNDSS-------ILSSGSYDGLIR 164 +S S E+ S P ND + L+ G+ DG IR Sbjct: 149 VSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIR 208 Query: 165 IFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVV 224 IFD + D K+E + + +S LL S D + +W G Sbjct: 209 IFDL-YKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGI-- 265 Query: 225 RTFQVQPLEKGVLHHSCGMDFLN 247 +Q P+ + L S G FLN Sbjct: 266 --WQGTPMLRHELLESVG--FLN 284 Score = 42.4 bits (98), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 29/156 (18%) Query: 53 SHARPFSELCWSPDGQCIATASDDFSVEIIHLS----YGLLHTFIGHTAPVISLTF---- 104 +H + + L SP+G+ A+AS D +V+I + G+L GH V ++ F Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILR---GHKRGVWTVRFAPLN 598 Query: 105 -----NRKGNL-----LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSV---DVPMNDS 151 +G++ + T S D++IK+W+ + + ++T HS V+ V + +DS Sbjct: 599 TPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDS 658 Query: 152 SI-----LSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 +S D L++++DA TG TL +D Sbjct: 659 ITKTKVQFASAGADTLVKVWDANTGETECTLDNHED 694 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 55/237 (23%), Positives = 91/237 (38%), Gaps = 56/237 (23%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIW--DTLNGSLM--KTISAHSEAVVSVDVPM- 148 GH V+SL + G+ + + S D + ++W D N S + H E+V +V +P Sbjct: 431 GHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKV 490 Query: 149 --------------NDSSILSSGSYDGLIRIFD--------AETGHCLKTLTYDKDWKRE 186 + + L SGS D ++ D + L+ L +DKD Sbjct: 491 VPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKD---- 546 Query: 187 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKG-------VLHH 239 I+ + S N + S D VKIWD V +VQ + +G V Sbjct: 547 -----INALDISPNGKLFASASQDKTVKIWD------VEKLEVQGILRGHKRGVWTVRFA 595 Query: 240 SCGMDFLNPEDGSTP---LVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 293 + E GS +V++G + I WN + ++ +G HS V+ + Sbjct: 596 PLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEG----HSHNVLKV 648 Score = 36.6 bits (83), Expect = 0.014, Method: Compositional matrix adjust. Identities = 41/163 (25%), Positives = 77/163 (47%), Gaps = 26/163 (15%) Query: 21 ISPDGQ-FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP------DGQ----- 68 ISP+G+ F + +Q + I+D+ + V Q ++ H R + ++P G+ Sbjct: 552 ISPNGKLFASASQDKTVKIWDVEKLEV-QGILRGHKRGVWTVRFAPLNTPVIQGEQGSVS 610 Query: 69 ---CIATASDDFSVEIIHLS-YGLLHTFIGHTAPVIS---LTFNR-----KGNLLFTSS- 115 + T S D ++++ +LS Y + TF GH+ V+ L +R K + F S+ Sbjct: 611 GRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAG 670 Query: 116 MDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS 158 D +K+WD G T+ H + + ++ V + + S+GS Sbjct: 671 ADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGS 713 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 30/148 (20%), Positives = 59/148 (39%), Gaps = 24/148 (16%) Query: 93 IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVD-VPMND- 150 + H + +L + G L ++S D+++KIWD + + H V +V P+N Sbjct: 541 LAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTP 600 Query: 151 -----------SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE 199 ++ +GS D I++++ C++T + V+ + + S Sbjct: 601 VIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFE-----GHSHNVLKVVWLHISR 655 Query: 200 NARYLLVK------SLDGVVKIWDCIGG 221 + K D +VK+WD G Sbjct: 656 DDSITKTKVQFASAGADTLVKVWDANTG 683 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 28/115 (24%), Positives = 53/115 (46%), Gaps = 5/115 (4%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 H + V + ++ + + L + S D+++ +W +G T E + SV +N+ Sbjct: 230 AHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGF-LNEGKW 288 Query: 154 LSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKS 208 + S G++RI+D T H +T +D K E G +S V E + L ++ Sbjct: 289 MYSAGTSGVLRIWDTTTHH---EITKKQDAKSE-GEAILSAVSLPERSLILCAQA 339 >2YNP-A nrPDB Length = 604 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 92/218 (42%), Gaps = 21/218 (9%) Query: 70 IATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 I SDDF + + + + G + F H + S+ + + + S D ++K+W+ N Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN 129 Query: 129 -SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN 187 +L +T H V+ V D S +SG D ++++ TLT +E Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTT----GQER 185 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ--VQPLEKGVLHHSCGMDF 245 GV + + Y++ S D +KIWD V T + + + V H + Sbjct: 186 GVNYVDYYPLPDKP-YMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTL---- 240 Query: 246 LNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSL 283 P++ISG E+G + WNS T + + L+ L Sbjct: 241 --------PIIISGSEDGTLKIWNSSTYKVEKTLNVGL 270 Score = 35.0 bits (79), Expect = 0.037, Method: Compositional matrix adjust. Identities = 26/107 (24%), Positives = 54/107 (50%), Gaps = 3/107 (2%) Query: 36 ILIYDINRRTVSQTLVTSHARPFSELCWSP--DGQCIATASDDFSVEII-HLSYGLLHTF 92 + ++ + + T + TL T R + + + P D + TASDD +++I + + + T Sbjct: 165 VKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL 224 Query: 93 IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSE 139 GH + V F+ ++ + S D ++KIW++ + KT++ E Sbjct: 225 EGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLE 271 >5WYK-BB nrPDB Length = 943 Score = 53.9 bits (128), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 34/115 (29%), Positives = 62/115 (53%), Gaps = 2/115 (1%) Query: 64 SPDGQCIATASDDFSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 SPD + +A + D +V++ L S + GH PV+S+ + ++ TSS D++IKI Sbjct: 540 SPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKI 599 Query: 123 WDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTL 177 W G K++ AH +++++V + S S S D +++ +D E C++ L Sbjct: 600 WGLDFGDCHKSLFAHQDSIMNVKF-LPQSHNFFSCSKDAVVKYWDGEKFECIQKL 653 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 40/154 (25%), Positives = 75/154 (48%), Gaps = 8/154 (5%) Query: 18 CAKISPDGQFLAIT---QGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 74 C ++SPD ++LAI+ + + D + +S + H P + S D + I T+S Sbjct: 536 CVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLS---LYGHKLPVLSIDISFDSKMIITSS 592 Query: 75 DDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 133 D +++I L +G H + H ++++ F + + F+ S D +K WD ++ Sbjct: 593 ADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQK 652 Query: 134 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 167 + AH V ++ V D + S S+D IRI++ Sbjct: 653 LYAHQSEVWALAVA-TDGGFVVSSSHDHSIRIWE 685 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 2/93 (2%) Query: 84 LSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVS 143 +S +L F GH A + L F+ G L + S D +I +WD + + + +H +++ Sbjct: 109 MSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITG 168 Query: 144 VDVPMNDSSILSSGSYDGLIRIFDAETGHCLKT 176 D L S S DG+I+++D +T C++T Sbjct: 169 FWCQGED--WLISTSKDGMIKLWDLKTHQCIET 199 Score = 32.3 bits (72), Expect = 0.27, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 46/106 (43%), Gaps = 5/106 (4%) Query: 21 ISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVE 80 IS D + LA ++ I++I +T +A L P G + + + ++ Sbjct: 399 ISDDNKLLATASNGSLKIWNIKTHKCIRTFECGYALTCKFL---PGGLLVILGTRNGELQ 455 Query: 81 IIHL-SYGLLHTFI-GHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 + L S LL T H A + SL G L T S D+++K WD Sbjct: 456 LFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWD 501 Score = 30.8 bits (68), Expect = 0.78, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 10/66 (15%) Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENG 263 L V DGV+K+WD + V+ F H + L DG+ +ISG ++ Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLNFN---------GHKAAITLLQF-DGTGTRLISGSKDS 143 Query: 264 DIYCWN 269 +I W+ Sbjct: 144 NIIVWD 149 Score = 30.8 bits (68), Expect = 0.90, Method: Compositional matrix adjust. Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 12/117 (10%) Query: 102 LTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDG 161 L ++ +LL D IK+WD ++ +++ + H A+ + + ++ SGS D Sbjct: 85 LEAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLI-SGSKDS 143 Query: 162 LIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF-SENARYLLVKSLDGVVKIWD 217 I ++D L L KD S F + +L+ S DG++K+WD Sbjct: 144 NIIVWDLVGEVGLYKLRSHKD----------SITGFWCQGEDWLISTSKDGMIKLWD 190 >3MKQ-A nrPDB Length = 814 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 93/218 (42%), Gaps = 21/218 (9%) Query: 70 IATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 I SDDF + + + + G + F H + S+ + + + S D ++K+W+ N Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN 129 Query: 129 -SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN 187 +L +T H V+ V D S +SG D ++++ TLT + E Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQ----ER 185 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF-- 245 GV + + Y++ S D +KIWD V T + H + F Sbjct: 186 GVNYVDYYPLPDKP-YMITASDDLTIKIWDYQTKSCVATLE---------GHMSNVSFAV 235 Query: 246 LNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSL 283 +P + P++ISG E+G + WNS T + + L+ L Sbjct: 236 FHP---TLPIIISGSEDGTLKIWNSSTYKVEKTLNVGL 270 Score = 34.7 bits (78), Expect = 0.050, Method: Compositional matrix adjust. Identities = 26/107 (24%), Positives = 54/107 (50%), Gaps = 3/107 (2%) Query: 36 ILIYDINRRTVSQTLVTSHARPFSELCWSP--DGQCIATASDDFSVEII-HLSYGLLHTF 92 + ++ + + T + TL T R + + + P D + TASDD +++I + + + T Sbjct: 165 VKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL 224 Query: 93 IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSE 139 GH + V F+ ++ + S D ++KIW++ + KT++ E Sbjct: 225 EGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLE 271 >6ID0-T nrPDB Length = 514 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 60/268 (22%), Positives = 108/268 (40%), Gaps = 24/268 (8%) Query: 18 CAKISPDGQ-FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 C + P Q F+ + I I+D+ + +L T H + S + + +D Sbjct: 209 CIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSL-TGHISTVRGVIVSTRSPYLFSCGED 267 Query: 77 FSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 V+ L Y ++ + GH + V L + ++L T S D + +IWD + + T+S Sbjct: 268 KQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLS 327 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 H+ AV +V + I+ +GS+D IR++D G TLT K R + P Sbjct: 328 GHTNAVATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHP---- 382 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 Y +K W G ++ H++ DG + Sbjct: 383 -----RHYTFASGSPDNIKQWKFPDGSFIQNLSG--------HNAIINTLTVNSDG---V 426 Query: 256 VISGYENGDIYCWNSDTKSLLQLLDGSL 283 ++SG +NG ++ W+ T Q + ++ Sbjct: 427 LVSGADNGTMHLWDWRTGYNFQRVHAAV 454 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 41/184 (22%), Positives = 84/184 (45%), Gaps = 13/184 (7%) Query: 38 IYDINRRTVSQTLVTSHARPFSEL-CWSPDGQCIATASDDFSVEIIHLSYGLLH-TFIGH 95 I+D+ + TL + H + + C + + Q I T S D ++ + L G T H Sbjct: 314 IWDVRTKASVHTL-SGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTRVTLTNH 371 Query: 96 TAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILS 155 V ++ + + + F S ++IK W +GS ++ +S H+ + ++ V N +L Sbjct: 372 KKSVRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTV--NSDGVLV 428 Query: 156 SGSYDGLIRIFDAETGHCLKTL---TYDKDWKRENGVVPISQVKFSENARYLLVKSLDGV 212 SG+ +G + ++D TG+ + + E+G+ + F ++ LL D Sbjct: 429 SGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACA---FDQSESRLLTAEADKT 485 Query: 213 VKIW 216 +K++ Sbjct: 486 IKVY 489 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 35/146 (23%), Positives = 54/146 (36%), Gaps = 11/146 (7%) Query: 83 HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVV 142 H + L GH V + T S D +IKIWD +G L +++ H V Sbjct: 191 HPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVR 250 Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENG-VVPISQVKFSENA 201 V V + S G D ++ +D L Y+K + +G + + + Sbjct: 251 GVIVSTRSPYLFSCGE-DKQVKCWD---------LEYNKVIRHYHGHLSAVYGLDLHPTI 300 Query: 202 RYLLVKSLDGVVKIWDCIGGCVVRTF 227 L+ S D +IWD V T Sbjct: 301 DVLVTCSRDSTARIWDVRTKASVHTL 326 >3JB9-g nrPDB Length = 558 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 72/154 (46%), Gaps = 11/154 (7%) Query: 67 GQCIATASDDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 G + + S D ++I ++ LL TF GH P+ L+F++ G ++S D++IK+WD Sbjct: 279 GHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWD 338 Query: 125 TLNGSLMKTISAHS-EAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDW 183 T G + ++ V V + + +G+ D I FD + ++ YD Sbjct: 339 TELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQ--AYD--- 393 Query: 184 KRENGVVPISQVKFSENARYLLVKSLDGVVKIWD 217 + + I+ + F EN + + S D ++ W+ Sbjct: 394 ---HHLGGINSITFLENGKRFVTTSDDSSMRFWE 424 Score = 31.2 bits (69), Expect = 0.59, Method: Compositional matrix adjust. Identities = 31/124 (25%), Positives = 50/124 (40%), Gaps = 9/124 (7%) Query: 51 VTSHARPFSELCWSPDGQCIATASDDFSVEII----HLSYGLLHTFIGHTAPVISLT--F 104 + H+ P + P+G+ IA S D + + F G++ SL F Sbjct: 437 IAMHSMP--RVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGF 494 Query: 105 NRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDV-PMNDSSILSSGSYDGLI 163 + G +F+ + WD LM + AHS V S+ P S + +S DG I Sbjct: 495 SPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSI 554 Query: 164 RIFD 167 + +D Sbjct: 555 KYWD 558 >2HES-X nrPDB Length = 330 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 51/187 (27%), Positives = 76/187 (40%), Gaps = 29/187 (15%) Query: 52 TSHARPFSELCWSPDGQCIATASDDFSVEIIH--------LSYGLLHTFIGHTAPVISLT 103 T+H + + W P +A S D +V I LL GH V + Sbjct: 55 TAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVA 114 Query: 104 FNRKGNLLFTSSMDESIKIWDT-LNGSLMKTISA---HSEAVVSVDVPMNDSSILSSGSY 159 ++ G L T S D+S+ IW+T +G + IS HS+ V V + ++L+S SY Sbjct: 115 WSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHV-IWHPSEALLASSSY 173 Query: 160 DGLIRIFDAETGHCLKTLTYDKDWK------RENGVVPISQVKFSENARYLLVKSLDGVV 213 D +RI+ YD DW+ G V S +E L S D V Sbjct: 174 DDTVRIWK----------DYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTV 223 Query: 214 KIWDCIG 220 ++W +G Sbjct: 224 RVWKYMG 230 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 32/126 (25%), Positives = 54/126 (42%), Gaps = 8/126 (6%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHL-----SYGLLHTFIGHTAPVISLT 103 ++ H + WS DG +AT S D SV I Y + H+ V + Sbjct: 101 AIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVI 160 Query: 104 FNRKGNLLFTSSMDESIKIWDTLNGSL--MKTISAHSEAVVSVDVPMNDSSI-LSSGSYD 160 ++ LL +SS D++++IW + + ++ H V S D + L SGS D Sbjct: 161 WHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDD 220 Query: 161 GLIRIF 166 +R++ Sbjct: 221 STVRVW 226 >3ACP-A nrPDB Length = 417 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 43/194 (22%), Positives = 83/194 (42%), Gaps = 29/194 (14%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 H + + L F G L +SS D +KIW +GS +T+ H V + + ++ Sbjct: 134 AHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNV 193 Query: 154 LSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS------------------QV 195 LS+ S DG IR+++ TG + T+++ +GV I+ + Sbjct: 194 LSA-SLDGTIRLWECGTGTTIH--TFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNL 250 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 +F +Y++ + GV+ + + +T Q+ +C + L + + Sbjct: 251 EFGTYGKYVIAGHVSGVITVHNVF--SKEQTIQLPS------KFTCSCNSLTVDGNNANY 302 Query: 256 VISGYENGDIYCWN 269 + +GYENG + W+ Sbjct: 303 IYAGYENGMLAQWD 316 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 31/122 (25%), Positives = 61/122 (50%), Gaps = 9/122 (7%) Query: 18 CAKISPDGQFLAITQGLNILIYDIN---RRTVSQTLVTSHARPFSELCWSPDGQCIATAS 74 AK+ L T+G +I + D N +R + Q +H ++L + P G+ + ++S Sbjct: 101 TAKLQMRRFILGTTEG-DIKVLDSNFNLQREIDQ----AHVSEITKLKFFPSGEALISSS 155 Query: 75 DDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 133 D ++I + G T IGH A V + +G + ++S+D +I++W+ G+ + T Sbjct: 156 QDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHT 215 Query: 134 IS 135 + Sbjct: 216 FN 217 >6J6H-n nrPDB Length = 455 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 63/153 (41%), Gaps = 8/153 (5%) Query: 67 GQCIATASDDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 G I + +D +++I + Y L F GH P+ +L F +SS D S+KIWD Sbjct: 175 GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 Query: 125 TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 T G + + +S P N + S ++ D + + TYD Sbjct: 235 TETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYD---- 290 Query: 185 RENGVVPISQVKFSENARYLLVKSLDGVVKIWD 217 + + I +K+ + + S D V+IW+ Sbjct: 291 --HHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/227 (21%), Positives = 94/227 (41%), Gaps = 21/227 (9%) Query: 83 HLSYGLLHTFIGHTAPVISLTF-NRKGNLLFTSSMDESIKIWDTLNG-SLMKTISAHSEA 140 +L ++ + GH +L F + G+L+ + D +IKIWD + ++ H++ Sbjct: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 Query: 141 VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN 200 + ++ + S LSS S+D ++I+D ETG L + P N Sbjct: 209 IKALRFTEDCQSFLSS-SFDRSVKIWDTETGKVKTRLHLNS--------TPADVESRPTN 259 Query: 201 ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNP-EDGSTPLVISG 259 +V + + +D R + Q L + HH + L DGS IS Sbjct: 260 PHEFIVGLSNSKILHYDD------RVSENQGLVQTYDHHLSSILALKYFPDGSK--FISS 311 Query: 260 YENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALN 306 E+ + W + ++ + + HS P +++H N C+ +++ Sbjct: 312 SEDKTVRIWENQINVPIKQISDTA-QHSMPFLNVHPSQNYFCAQSMD 357 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/203 (23%), Positives = 80/203 (39%), Gaps = 28/203 (13%) Query: 117 DESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD-AETGHCLK 175 +E I L +++ H E ++ ++ SG D I+I+D CL+ Sbjct: 141 EERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR 200 Query: 176 TLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKG 235 D++ N PI ++F+E+ + L S D VKIWD G V + Sbjct: 201 ------DFQGHNK--PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD 252 Query: 236 VLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN---SDTKSLLQLLDGSLYHHSSPVMS 292 V NP + I G N I ++ S+ + L+Q D HH S +++ Sbjct: 253 VESRPT-----NPHE-----FIVGLSNSKILHYDDRVSENQGLVQTYD----HHLSSILA 298 Query: 293 IHCF--GNIMCSLALNGDCCLWR 313 + F G+ S + + +W Sbjct: 299 LKYFPDGSKFISSSEDKTVRIWE 321 >6BX3-B nrPDB Length = 412 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 26/79 (32%), Positives = 47/79 (59%), Gaps = 4/79 (5%) Query: 11 QNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRT---VSQTLVTSHARPFSELCWSPD 66 +N L+ C + SP G +LA+ ++IYD++ V ++ +H RP + + WSPD Sbjct: 23 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 82 Query: 67 GQCIATASDDFSVEIIHLS 85 G+ + T+S D+S+++ LS Sbjct: 83 GRLLLTSSRDWSIKLWDLS 101 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 15/31 (48%), Positives = 20/31 (64%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 H P+ S+ ++ G LL TSS D SIK+WD Sbjct: 69 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 99 Score = 28.9 bits (63), Expect = 3.3, Method: Compositional matrix adjust. Identities = 12/29 (41%), Positives = 18/29 (62%) Query: 189 VVPISQVKFSENARYLLVKSLDGVVKIWD 217 V PI+ + +S + R LL S D +K+WD Sbjct: 71 VRPITSIAWSPDGRLLLTSSRDWSIKLWD 99 Score = 27.7 bits (60), Expect = 6.9, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 13/79 (16%) Query: 195 VKFSENARYLLVKSLDGV----VKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 + FS N LV S G + IW+ G +VR ++ E+ ++ DF Sbjct: 271 ILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRV--LEGAEEELI--DINWDFY---- 322 Query: 251 GSTPLVISGYENGDIYCWN 269 S +V +G+E+G++Y W+ Sbjct: 323 -SMSIVSNGFESGNVYVWS 340 Score = 27.3 bits (59), Expect = 9.7, Method: Compositional matrix adjust. Identities = 11/48 (22%), Positives = 27/48 (56%) Query: 119 SIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 + IW+T +G+L++ + E ++ ++ SI+S+G G + ++ Sbjct: 292 ELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVW 339 >5FVM-C nrPDB Length = 303 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 9/126 (7%) Query: 91 TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMND 150 +F GH V S+ F ++ + +SS D +IK+WD + S+ + H+ V V + N Sbjct: 70 SFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEVAIHPNQ 128 Query: 151 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLD 210 ++S DG IRI+D C LT + + P+ + + + L+ + Sbjct: 129 GELISCDQ-DGNIRIWDLGENQCTNQLTPEDN-------TPLQSLSVASDGSMLVAGNNK 180 Query: 211 GVVKIW 216 G +W Sbjct: 181 GNCYVW 186 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 41/208 (19%), Positives = 94/208 (45%), Gaps = 28/208 (13%) Query: 110 LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 +L ++ D +I+ W+ L G +TI V +++ + + ++G +R++D Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLH--VRLYDIR 61 Query: 170 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQV 229 + + ++ E ++ + F + R+++ S DG +K+WD V R ++ Sbjct: 62 SNNPNPVSSF------EGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYKH 115 Query: 230 Q-PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN-SDTKSLLQLLDGSLYHHS 287 P+ + +H P G +IS ++G+I W+ + + QL + Sbjct: 116 NAPVNEVAIH---------PNQGE---LISCDQDGNIRIWDLGENQCTNQLTPED----N 159 Query: 288 SPV--MSIHCFGNIMCSLALNGDCCLWR 313 +P+ +S+ G+++ + G+C +WR Sbjct: 160 TPLQSLSVASDGSMLVAGNNKGNCYVWR 187 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 10/138 (7%) Query: 21 ISPDGQFL-AITQGLNILIYDINRRTVSQTL-----VTSHARPFSELCWSPDGQCIATAS 74 ++ DG L A N ++ + T + TL SH + + + S D + +AT S Sbjct: 167 VASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCS 226 Query: 75 DDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK 132 D + + I +Y L T GH V F+ L T+ D +++WD +++ Sbjct: 227 ADHTARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVR 286 Query: 133 TISAHSEAVVSVDVPMND 150 H + V V +ND Sbjct: 287 QYGGHHKGAVC--VALND 302 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 48/261 (18%), Positives = 102/261 (39%), Gaps = 64/261 (24%) Query: 20 KISPDGQFLAITQGLNILIYDINRRTVSQTLVTS---HARPFSELCWSPDGQCIATASDD 76 +I+ D ++LA L++ +YDI R+ + V+S H + + + + + + ++S+D Sbjct: 39 EITSDKKYLAAAGHLHVRLYDI--RSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSED 96 Query: 77 FSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD------------ 124 ++++ + + H APV + + L + D +I+IWD Sbjct: 97 GTIKVWDVRSPSVQRNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTP 156 Query: 125 -----------TLNGSLM--------------------------KTISAHSEAVVSVDVP 147 +GS++ +H++ + V + Sbjct: 157 EDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLS 216 Query: 148 MNDSSILSSGSYDGLIRIFDAETGHCLKT-LTYDKDWKRENGVVPISQVKFSENARYLLV 206 D L++ S D R+++ E + L+T L + W + FS ++ YL+ Sbjct: 217 A-DVKNLATCSADHTARVWNIEDNYQLETTLDGHQRW--------VWDCAFSADSAYLVT 267 Query: 207 KSLDGVVKIWDCIGGCVVRTF 227 D V++WD +VR + Sbjct: 268 ACSDHYVRLWDLSTSEIVRQY 288 >5XYI-g nrPDB Length = 335 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 52/194 (26%), Positives = 90/194 (46%), Gaps = 27/194 (13%) Query: 91 TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN------GSLMKTISAHSEAVVSV 144 TF+GH A + S+ + + N L ++S D+S +W LN + + H+ V V Sbjct: 28 TFVGHNAAIESIEIDNEHNYLVSASRDKSALVWK-LNRTQEQWATPFTRLIGHNHFVSDV 86 Query: 145 DVPMNDSSILSSGSYDGLIRIFDAETGHCLKT-LTYDKDWKRENGVVPISQVKFSENARY 203 + + S +L+S S+D +R++D T K L + KD + V FS R Sbjct: 87 SLSRDASHLLTS-SWDSTLRLWDLSTRTTKKLFLGHKKD---------VLGVTFSPCNRR 136 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS-GYEN 262 ++ D VKIW+ +G ++Q V +C D ++PLVI+ G + Sbjct: 137 IISVGRDNQVKIWNILGE---NKAELQ-CSSWVTSVACAP----MADETSPLVIAVGCWD 188 Query: 263 GDIYCWNSDTKSLL 276 G +Y W+ + ++ L Sbjct: 189 GKVYIWSIEKEAKL 202 Score = 33.9 bits (76), Expect = 0.10, Method: Compositional matrix adjust. Identities = 32/139 (23%), Positives = 58/139 (41%), Gaps = 6/139 (4%) Query: 82 IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAV 141 I L+ F H S+ F G + T D + +W T NG+ KTIS + + Sbjct: 196 IEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGA--KTISFTAPSP 253 Query: 142 VSVDVPMNDSSILSSGSYDGLIRIFD--AETGHCLKTLTYDKDWKRENGVVP-ISQVKFS 198 V + + + +Y+G I ++D A+ L + + KR G P + + ++ Sbjct: 254 VHAVAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWA 312 Query: 199 ENARYLLVKSLDGVVKIWD 217 + L DG ++ W+ Sbjct: 313 ADGSVLYSGYNDGSIRAWE 331 >4V6W-Ag nrPDB Length = 318 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 43/171 (25%), Positives = 80/171 (46%), Gaps = 22/171 (12%) Query: 66 DGQCIATASDDFSVEIIHLS------YGLLHTFI-GHTAPVISLTFNRKGNLLFTSSMDE 118 D I +AS D ++ + L+ YG + GH+ + + + GN + S D+ Sbjct: 27 DPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNYALSGSWDQ 86 Query: 119 SIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLT 178 ++++WD G + H++ V+SV ++ I+ SGS D I++++ C T+ Sbjct: 87 TLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIV-SGSRDKTIKLWNT-LAECKFTIQ 144 Query: 179 YD--KDWKRENGVVPISQVKFSENARYLLVKS--LDGVVKIWDCIGGCVVR 225 D DW +S V+FS N ++ S D VK+W+ + C ++ Sbjct: 145 EDGHTDW--------VSCVRFSPNHSNPIIVSCGWDRTVKVWN-LANCKLK 186 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/124 (27%), Positives = 62/124 (50%), Gaps = 5/124 (4%) Query: 48 QTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNR 106 Q + H+ S++ S DG + S D ++ + L+ G F GHT V+S+ F+ Sbjct: 57 QKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSA 116 Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKTIS--AHSEAVVSVDVPMNDSS-ILSSGSYDGLI 163 + + S D++IK+W+TL TI H++ V V N S+ I+ S +D + Sbjct: 117 DNRQIVSGSRDKTIKLWNTL-AECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTV 175 Query: 164 RIFD 167 ++++ Sbjct: 176 KVWN 179 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 18/73 (24%), Positives = 32/73 (43%), Gaps = 8/73 (10%) Query: 21 ISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSE--------LCWSPDGQCIAT 72 SP+ +L + G +I I+D+ + + L P S+ L WS DGQ + Sbjct: 242 FSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFA 301 Query: 73 ASDDFSVEIIHLS 85 D ++ + +S Sbjct: 302 GYSDNTIRVWQVS 314 >6N9G-C nrPDB Length = 353 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 5/133 (3%) Query: 37 LIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHT 96 +++D+ Q T H + + + P G A+ SDD + + L Sbjct: 222 MVWDMRSGQCVQAFET-HESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKE 280 Query: 97 APVI---SLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 + + S+ F+ G LLF D +I +WD L GS + + H V ++ V D + Sbjct: 281 SIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS-PDGTA 339 Query: 154 LSSGSYDGLIRIF 166 SGS+D +R++ Sbjct: 340 FCSGSWDHTLRVW 352 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 47/249 (18%), Positives = 99/249 (39%), Gaps = 28/249 (11%) Query: 63 WSPDGQCIATASDDFSVEIIHLSYGLLHTFIG-------HTAPVISLTFNRKGNLLFTSS 115 ++P G IA D + L++ HT + + +F + T+S Sbjct: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172 Query: 116 MDESIKIWDTLNGSLMKTISAHSEAVVSVDV-PMNDSSILSSGSYDGLIRIFDAETGHCL 174 D + +WD +G L+++ H V+ +D+ P + SG D ++D +G C+ Sbjct: 173 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232 Query: 175 KTL-TYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 + T++ D ++ V++ + S D +++D V + + Sbjct: 233 QAFETHESD---------VNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS----K 279 Query: 234 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 293 + ++ + +DF S L+ +GY + I W+ S + +L G + + + + Sbjct: 280 ESIIFGASSVDF----SLSGRLLFAGYNDYTINVWDVLKGSRVSILFG--HENRVSTLRV 333 Query: 294 HCFGNIMCS 302 G CS Sbjct: 334 SPDGTAFCS 342 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 48/235 (20%), Positives = 93/235 (39%), Gaps = 37/235 (15%) Query: 90 HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN 149 T GH V+ + + + + +SS D + +WD+ + ++ V++ + Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116 Query: 150 DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP----------ISQVKFSE 199 +I + G D ++ LT+DK+ EN +S F+ Sbjct: 117 GCAI-ACGGLDNKCSVY---------PLTFDKN---ENMAAKKKSVAMHTNYLSACSFTN 163 Query: 200 NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 259 + +L S DG +WD G ++++F + VL C +D E G+T +SG Sbjct: 164 SDMQILTASGDGTCALWDVESGQLLQSFHGHGAD--VL---C-LDLAPSETGNT--FVSG 215 Query: 260 YENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF--GNIMCSLALNGDCCLW 312 + W+ + +Q + H S V S+ + G+ S + + C L+ Sbjct: 216 GCDKKAMVWDMRSGQCVQAFET----HESDVNSVRYYPSGDAFASGSDDATCRLY 266 >6EOJ-D nrPDB Length = 470 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 53/235 (22%), Positives = 104/235 (44%), Gaps = 37/235 (15%) Query: 61 LCWSPDGQ--CIATASDDFSVEIIHLSYGLLHTFI-GHTAPVISLTFNRKGNLLFTSSMD 117 + W+P+G+ +AT S +FS + + S T + H + V ++ ++ + + + D Sbjct: 99 IQWTPEGRRLVVATYSGEFS--LWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 Query: 118 ESIKIWDTLNGSLMKTI-SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKT 176 IKIW N S++K I +AH+E++ + NDS ++ S D +++I++ G + Sbjct: 157 GMIKIWQP-NFSMVKEIDAAHTESIRDMAFSSNDSKFVTC-SDDNILKIWNFSNGKQERV 214 Query: 177 LTYDK------DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI-GGCVVRTFQV 229 L+ DW E G++ + S D +VK+WD G C+ + Sbjct: 215 LSGHHWDVKSCDWHPEMGLIASA--------------SKDNLVKLWDPRSGNCISSILKF 260 Query: 230 QPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLY 284 + H+ P G+ + IS ++ ++ K L+ + D + Y Sbjct: 261 K--------HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY 307 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/121 (23%), Positives = 56/121 (46%), Gaps = 1/121 (0%) Query: 48 QTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFI-GHTAPVISLTFNR 106 + + +H ++ +S + T SDD ++I + S G + GH V S ++ Sbjct: 170 KEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP 229 Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 + L+ ++S D +K+WD +G+ + +I V+ ++L + S D R+F Sbjct: 230 EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 Query: 167 D 167 D Sbjct: 290 D 290 >3ODT-A nrPDB Length = 313 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/147 (26%), Positives = 73/147 (49%), Gaps = 7/147 (4%) Query: 24 DGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIH 83 + +FL + I ++ ++ V +T H L DG I+ ++D ++++ Sbjct: 155 ENKFLTASADKTIKLWQNDK--VIKTFSGIHNDVVRHLAVVDDGHFISCSNDGL-IKLVD 211 Query: 84 LSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVV 142 + G +L T+ GH + V + G+++ + D +++IW NGSL + I+ + ++ Sbjct: 212 MHTGDVLRTYEGHESFVYCIKLLPNGDIV-SCGEDRTVRIWSKENGSLKQVITLPAISIW 270 Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAE 169 SVD N I+ GS D L+RIF E Sbjct: 271 SVDCMSNGDIIV--GSSDNLVRIFSQE 295 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 49/183 (26%), Positives = 85/183 (46%), Gaps = 29/183 (15%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPM 148 L+T IGH V SL+F + ++ + S D++ K+W GSL+ + AH+ +V V Sbjct: 97 LYTLIGHQGNVCSLSF--QDGVVISGSWDKTAKVWK--EGSLVYNLQAHNASVWDAKVVS 152 Query: 149 NDSSILSSGSYDGLIRIFDAETGHCLKTLT-YDKDWKRENGVVPISQVKFSENARYLLVK 207 + + S D I+++ + +KT + D R VV + + + Sbjct: 153 FSENKFLTASADKTIKLW--QNDKVIKTFSGIHNDVVRHLAVV---------DDGHFISC 201 Query: 208 SLDGVVKIWDCIGGCVVRTFQ--------VQPLEKGVLHHSCGMD----FLNPEDGSTPL 255 S DG++K+ D G V+RT++ ++ L G + SCG D + E+GS Sbjct: 202 SNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDI-VSCGEDRTVRIWSKENGSLKQ 260 Query: 256 VIS 258 VI+ Sbjct: 261 VIT 263 >6QX9-4B nrPDB Length = 522 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 68/178 (38%), Gaps = 9/178 (5%) Query: 7 PVGTQNGLKATCAKI--SPDGQFLAIT---QGLNILIYDINRRTVSQTLVTSHARPFSEL 61 PV G A++ P G+FL T + + + + Q H+ ++ Sbjct: 315 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQE---GHSMGVYDI 371 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFI-GHTAPVISLTFNRKGNLLFTSSMDESI 120 + DG T D + L G F+ GH + + F+ G + T S D + Sbjct: 372 AFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTC 431 Query: 121 KIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLT 178 K+WD + TI AH V V + L +G+YD +I+ LKTL Sbjct: 432 KVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLA 489 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 47/212 (22%), Positives = 77/212 (36%), Gaps = 58/212 (27%) Query: 56 RPFSELCWSPDGQCIATASDDFSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNL---- 110 RP S +SP+ + +ATA ++ + LLHT GH V ++ F+ K + Sbjct: 232 RPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDP 291 Query: 111 ----LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSV---------------------- 144 L + + D S+K+W + + I H+ V V Sbjct: 292 KDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 351 Query: 145 ------------------DVPMN-DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKR 185 D+ + D S+ +G D R++D TG C+ L Sbjct: 352 LEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL-------- 403 Query: 186 ENGVVPISQVKFSENARYLLVKSLDGVVKIWD 217 E + I + FS N ++ S D K+WD Sbjct: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 435 Score = 27.3 bits (59), Expect = 8.6, Method: Compositional matrix adjust. Identities = 24/114 (21%), Positives = 48/114 (42%), Gaps = 11/114 (9%) Query: 191 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKG-VLHHSCGMDFLNPE 249 PIS FS N++ L G+ K+W ++ T + G ++ H L+P+ Sbjct: 233 PISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPK 292 Query: 250 DGSTPLVISGYENGDIYCWNSDTKSLLQLLDGS-------LYHHSSPVMSIHCF 296 D + + S +G + W+ D+ + ++G ++H S + C+ Sbjct: 293 DVN---LASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCY 343 >5WLC-LU nrPDB Length = 489 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 83/200 (41%), Gaps = 34/200 (17%) Query: 31 TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG-----------QCIATASDDFSV 79 T G I ++D+NR +P S+L W D +A+ D S+ Sbjct: 196 TGGAKIHLWDVNR-----------LKPVSDLSWGADNITSLKFNQNETDILASTGSDNSI 244 Query: 80 EIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLF-TSSMDESIKIWDTLNGSL-MKTISAH 137 + L I T ++ +N F T++ D + +D N S + H Sbjct: 245 VLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDH 304 Query: 138 SEAVVSVDV-PMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK 196 AV+ VD P D + +GSYD IRI+ GH + + + + QVK Sbjct: 305 VSAVMDVDFSPTGDEIV--TGSYDKSIRIYKTNHGHSREIYHTKR-------MQHVFQVK 355 Query: 197 FSENARYLLVKSLDGVVKIW 216 +S +++Y++ S DG V++W Sbjct: 356 YSMDSKYIISGSDDGNVRLW 375 Score = 32.7 bits (73), Expect = 0.20, Method: Compositional matrix adjust. Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 4/100 (4%) Query: 27 FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY 86 F+ + N YD+ + S + H ++ +SP G I T S D S+ I ++ Sbjct: 277 FVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNH 336 Query: 87 GLLHTFIGHTAP---VISLTFNRKGNLLFTSSMDESIKIW 123 G I HT V + ++ + + S D ++++W Sbjct: 337 GHSRE-IYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 >2AQ5-A nrPDB Length = 402 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/188 (25%), Positives = 80/188 (42%), Gaps = 24/188 (12%) Query: 25 GQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP-DGQCIATASDDFSVEIIH 83 G FL + G R + LV H P ++ W P + IA+ S+D +V + Sbjct: 57 GAFLVLPLG------KTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWE 110 Query: 84 LSYGLLH--------TFIGHTAPVISLTFNRKG-NLLFTSSMDESIKIWDTLNGSLMKTI 134 + G L T GHT V + ++ N+L ++ D I +WD G+ + T+ Sbjct: 111 IPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTL 170 Query: 135 SA--HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 H + + SVD D +++ + D +R+ + G T+ +KD E G P+ Sbjct: 171 GPDVHPDTIYSVDW-SRDGALICTSCRDKRVRVIEPRKG----TVVAEKDRPHE-GTRPV 224 Query: 193 SQVKFSEN 200 V SE Sbjct: 225 HAVFVSEG 232 >5MWJ-A nrPDB Length = 337 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 70/152 (46%), Gaps = 3/152 (1%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 A+C IS DG L T GL+ + + R Q L + P G+ +A + Sbjct: 186 ASCIDISNDGTKL-WTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGME 244 Query: 76 DFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 +VE++H++ + H + V+SL F G ++ D + W T G+ + S Sbjct: 245 SSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQ-S 303 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 167 S +V+S D+ ++D I+ +GS D +++ Sbjct: 304 KESSSVLSCDISVDDKYIV-TGSGDKKATVYE 334 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 21/81 (25%), Positives = 40/81 (49%), Gaps = 2/81 (2%) Query: 96 TAPV-ISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSIL 154 +AP +L + + F+ D +I +WD N +L++ H++ +D+ ND + L Sbjct: 140 SAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDI-SNDGTKL 198 Query: 155 SSGSYDGLIRIFDAETGHCLK 175 +G D +R +D G L+ Sbjct: 199 WTGGLDNTVRSWDLREGRQLQ 219 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 53/116 (45%), Gaps = 3/116 (2%) Query: 20 KISPDGQFLAITQGLNIL-IYDINRRTVS-QTLVTSHARPFSELCWSPDGQCIATASDDF 77 K+ PDG L + + L I+D+ T + +TS A L SPD + + D Sbjct: 104 KLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDG 163 Query: 78 SVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK 132 ++ + L + L+ F GHT + + G L+T +D +++ WD G ++ Sbjct: 164 NIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 219 >4OWR-A nrPDB Length = 339 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 26/80 (32%), Positives = 42/80 (52%), Gaps = 2/80 (2%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNL--L 111 H P ++CWS DG + TAS D + ++ LS H APV ++ + + N + Sbjct: 56 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCV 115 Query: 112 FTSSMDESIKIWDTLNGSLM 131 T S D+++K WDT + + M Sbjct: 116 MTGSWDKTLKFWDTRSSNPM 135 >4AEZ-A nrPDB Length = 401 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/161 (26%), Positives = 75/161 (46%), Gaps = 4/161 (2%) Query: 20 KISPDGQFLAITQGLNIL-IYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFS 78 K S DG FL++ G ++ IYD+ +T +T+ AR L W+ + S Sbjct: 141 KWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQAR-VGCLSWNRHVLSSGSRSGAIH 199 Query: 79 VEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHS 138 + ++ + T GH++ V L + G L + D ++IWD + T + H+ Sbjct: 200 HHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHN 259 Query: 139 EAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTL 177 AV +V S++L++ G+ D I ++A TG + T+ Sbjct: 260 AAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTV 300 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 57/290 (19%), Positives = 119/290 (41%), Gaps = 23/290 (7%) Query: 28 LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHL-SY 86 +A+ N+ +++ + +VS T + + + WS DG ++ + V+I + S Sbjct: 107 VAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQ 166 Query: 87 GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT-LNGSLMKTISAHSEAVVSVD 145 L T GH A V L++NR ++L + S +I D + + T+ HS V + Sbjct: 167 TKLRTMAGHQARVGCLSWNR--HVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGL- 223 Query: 146 VPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLL 205 +D L+SG D +++I+DA + T T V ++ + N Sbjct: 224 AWRSDGLQLASGGNDNVVQIWDARSSIPKFTKT-----NHNAAVKAVAWCPWQSNLLATG 278 Query: 206 VKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDI 265 ++D + W+ G V T ++ + ++ G+ + ++ Sbjct: 279 GGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTH---------GFPDNNL 329 Query: 266 YCWNSDTKSLLQLLDGSLYHHSSPVM--SIHCFGNIMCSLALNGDCCLWR 313 W+ + L + +D + H + V+ ++ G I+ + A + + WR Sbjct: 330 SIWSYSSSGLTKQVD--IPAHDTRVLYSALSPDGRILSTAASDENLKFWR 377 >3BG0-A nrPDB Length = 316 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 41/130 (31%), Positives = 60/130 (46%), Gaps = 8/130 (6%) Query: 45 TVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG---LLHTFIGHTAPVIS 101 +V T+ TSH + G +AT S D SV+I + G L+ GH PV Sbjct: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 Query: 102 LTFNRK--GNLLFTSSMDESIKIWDTLNGSLMKT--ISAHSEAVVSV-DVPMNDSSILSS 156 + + GN+L + S D + IW NG+ K+ + H +V SV P + IL+ Sbjct: 63 VAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILAC 122 Query: 157 GSYDGLIRIF 166 GS DG I + Sbjct: 123 GSSDGAISLL 132 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 27/73 (36%), Positives = 37/73 (50%), Gaps = 5/73 (6%) Query: 108 GNLLFTSSMDESIKIWDTLNGS--LMKTISAHSEAV--VSVDVPMNDSSILSSGSYDGLI 163 G L T S D S+KI+D NG L+ + H V V+ PM +IL+S SYD + Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY-GNILASCSYDRKV 83 Query: 164 RIFDAETGHCLKT 176 I+ E G K+ Sbjct: 84 IIWREENGTWEKS 96 >4BTS-AR nrPDB Length = 343 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 49/213 (23%), Positives = 94/213 (44%), Gaps = 27/213 (12%) Query: 74 SDDFSVEIIHLSYGLLHTFIGHTAPVISLT--FNRKGN----LLFTSSMDESIKIW---- 123 +D+ S++I + G+L GH+ V S+ F++K N +L + S D+++ IW Sbjct: 2 ADNSSLDIQVVKRGILE---GHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYE 58 Query: 124 DTLNGSL---MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYD 180 + NG K ++ H+ V + + + +SS S+D +R++D TG K Sbjct: 59 EEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISS-SWDKTLRLWDLRTGTTYKRFVGH 117 Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGV--LH 238 + + V FS + R +L + +K+W+ +G C + + + V + Sbjct: 118 QS--------EVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVR 169 Query: 239 HSCGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 +S M N P S +G + WN++ Sbjct: 170 YSPIMKSANKVQPFAPYFASVGWDGRLKVWNTN 202 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 16/63 (25%), Positives = 31/63 (49%) Query: 65 PDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 P A+ D +++ + ++ + +TF H + V L+ + G + T D+ + IWD Sbjct: 182 PFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWD 241 Query: 125 TLN 127 LN Sbjct: 242 ILN 244 >5OQL-L nrPDB Length = 557 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 83/178 (46%), Gaps = 14/178 (7%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 F +GT + ++ + A+T G + I+ I +R +T+ R SE Sbjct: 47 ISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTI----GRFDSEA 102 Query: 62 -CWS--PDGQCIATASDDFSVEIIHLSYG----LLHTFIGHTAPV-ISLTFNRKGNLLFT 113 C PDG+ + D +++ + G +L T+ H PV ++ + L + Sbjct: 103 HCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMS 162 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVV-SVDVPMN-DSSILSSGSYDGLIRIFDAE 169 S D+++++WD + + + H++ V +P + +S++L SGSYD +R++DA Sbjct: 163 CSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDAR 220 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 17/72 (23%), Positives = 33/72 (45%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFT 113 HA P ++ P G + AS + + ++ L H V SL+ +G + + Sbjct: 231 HADPIEDVLPLPSGTTLLAASGNAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVS 290 Query: 114 SSMDESIKIWDT 125 S+D +K+++T Sbjct: 291 GSLDGHVKVFET 302 >1NR0-A nrPDB Length = 611 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/151 (25%), Positives = 78/151 (51%), Gaps = 11/151 (7%) Query: 16 ATCAKISPDGQFLAIT-QGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 74 ++C +S D QF+A+ Q + +Y ++ +VS+ H + + +S +G + + Sbjct: 451 SSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV--A 508 Query: 75 DDFSVEIIHLS----YGLLHT--FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 D S ++I S + L HT + HTA V ++++ L T S+D S+ +W+ Sbjct: 509 TDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKP 568 Query: 129 SLMKTI--SAHSEAVVSVDVPMNDSSILSSG 157 S I AH+ + V+ + +N+++I+S+G Sbjct: 569 SDHPIIIKGAHAMSSVNSVIWLNETTIVSAG 599 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 39/182 (21%), Positives = 70/182 (38%), Gaps = 16/182 (8%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIH----LSYGLLH----TFIGHTAPVISLTFN 105 H + + ++PDG A+ D ++ + + G+ + H+ V LT++ Sbjct: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 Query: 106 RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRI 165 G + ++S D++IKIW+ + KTI + + L S S +G I Sbjct: 249 PDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINF 308 Query: 166 FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR 225 + E G D R I+ + S + + L +G + WD G R Sbjct: 309 VNPELGSI--------DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNR 360 Query: 226 TF 227 F Sbjct: 361 VF 362 Score = 35.0 bits (79), Expect = 0.044, Method: Compositional matrix adjust. Identities = 44/183 (24%), Positives = 78/183 (42%), Gaps = 19/183 (10%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQFLAITQG-LNILIYDINRRTVSQTLV------TSH 54 F+F + G + +PDG A T G I++Y+ T + +H Sbjct: 180 FKFKSTFGEHTKF-VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAH 238 Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS 114 + L WSPDG IA+AS D +++I + + + T PV + +++ +++T Sbjct: 239 SGSVFGLTWSPDGTKIASASADKTIKI----WNVATLKVEKTIPVGTRIEDQQLGIIWTK 294 Query: 115 SMDESIKIWDTLN------GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 SI +N GS+ + H++A+ ++ D L S +G I +D Sbjct: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSA-DGKTLFSADAEGHINSWDI 353 Query: 169 ETG 171 TG Sbjct: 354 STG 356 >5OV3-A nrPDB Length = 381 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 1/81 (1%) Query: 99 VISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS 158 ++ TFNR G LL D I IWD L + K ISAH V S+ D L S S Sbjct: 28 ALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSL-CWSRDGHKLVSAS 86 Query: 159 YDGLIRIFDAETGHCLKTLTY 179 D ++ +D +G C + + Sbjct: 87 TDNIVSQWDVLSGDCDQRFRF 107 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 55/279 (19%), Positives = 117/279 (41%), Gaps = 42/279 (15%) Query: 25 GQFLAITQGLN---ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEI 81 G LA+ G N I+I+D R +++ ++++H P LCWS DG + +AS D V Sbjct: 37 GTLLAV--GCNDGRIVIWDFLTRGIAK-IISAHIHPVCSLCWSRDGHKLVSASTDNIVSQ 93 Query: 82 IHLSYGLLHTFIGHTAPVISLTFN-RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEA 140 + G +P++ + ++ R N + M + +M T+S Sbjct: 94 WDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMK---------SAPVMLTLSDSKHV 144 Query: 141 VVSVDVPMNDSSILSSGSYD------------GLIRIFDAETGHCLKTLTYDKDWKRENG 188 V+ VD +DS + S+D G I + ++ + + + Sbjct: 145 VLPVD---DDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTG---TSN 198 Query: 189 VVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVV---RTFQVQPLEK--GVLHHSCGM 243 I ++F+ L+ + D +++++D G ++ R + +P++K +++ + Sbjct: 199 TTAIKSIEFARKGSCFLINTADRIIRVYD--GREILTCGRDGEPEPMQKLQDLVNRTPWK 256 Query: 244 DFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGS 282 DG + S ++ +Y W +L+++L G+ Sbjct: 257 KCCFSGDGEYIVAGSARQHA-LYIWEKSIGNLVKILHGT 294 >5OQL-X nrPDB Length = 630 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 24/102 (23%), Positives = 47/102 (46%), Gaps = 2/102 (1%) Query: 64 SPDGQCIATASDDFSVEIIHLS-YGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 S DG+ + T D + + + + + F H V L F R N L++ S D ++K+ Sbjct: 255 SQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKV 314 Query: 123 WDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIR 164 W + ++T+ H + ++ +D + +S G+ D R Sbjct: 315 WSLDELAYVETLFGHQDEILDIDA-LGQERCVSVGARDRTAR 355 >4N14-A nrPDB Length = 314 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 72/163 (44%), Gaps = 17/163 (10%) Query: 63 WSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFTSSMDES 119 WS G +A A D+ SV + S G + + P + S+ + ++GN L + Sbjct: 29 WS-SGNVLAVALDN-SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 86 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG-HCLKTLT 178 +++WD ++ +++HS V S+ +S ILSSGS G I D H + TL+ Sbjct: 87 VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLS 143 Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 + ++++ + R+L D +V +W G Sbjct: 144 GHSQ--------EVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 178 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 8/97 (8%) Query: 51 VTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-----LHTFIGHTAPVISLTF- 104 ++ H++ L W+PDG+ +A+ +D V + + G L TF H V ++ + Sbjct: 142 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 201 Query: 105 NRKGNLLFTS--SMDESIKIWDTLNGSLMKTISAHSE 139 + N+L T + D I+IW+ +G+ + + AHS+ Sbjct: 202 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 238 Score = 30.8 bits (68), Expect = 0.90, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 22/30 (73%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 GHT+ V+SLT + G + +++ DE++++W Sbjct: 278 GHTSRVLSLTMSPDGATVASAAADETLRLW 307 >6E29-D nrPDB Length = 345 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 61/304 (20%), Positives = 125/304 (41%), Gaps = 57/304 (18%) Query: 16 ATCAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 74 +TC + + G FLA + ++I+D+ V++ L H++ + L WS G+ + +A Sbjct: 28 STCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKL-RGHSKNITSLSWSRCGRYLLSAC 86 Query: 75 DDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSM----------DESIKIWD 124 + V + L G + + APV + + F +++ E +++ Sbjct: 87 QGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPVEVRY 146 Query: 125 TLNGSLMKTISAHSEAVVSVDVPMNDSSILS-------------SGSYDGLIRIFDAETG 171 L S+ K S ++ + D+ ++ +G+ G + I DA T Sbjct: 147 VL-PSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDART- 204 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW------------DCI 219 + + Y + K +G+ I+ ++ +E+ R LLV + D +++ + D I Sbjct: 205 ---REIIYSE--KIASGI--ITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTI 257 Query: 220 GGCVVRTFQ--VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQ 277 + FQ V L + S ++ + S Y N ++Y W SL++ Sbjct: 258 QLPLEHKFQDVVNRLSWNHVAFSATGEY---------VAASTYNNHELYIWERGHGSLVR 308 Query: 278 LLDG 281 +L+G Sbjct: 309 MLEG 312 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 24/105 (22%), Positives = 48/105 (45%), Gaps = 3/105 (2%) Query: 33 GLNILIYDINRRTVSQTLVTSHARPFSELC--WSPDGQCIATASDDFSVEIIHL-SYGLL 89 G+N+L+ D +T+ R C ++ G +A+ D +V I L + G+ Sbjct: 1 GMNLLLSDDYLLQDYPENITNTIRSGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVA 60 Query: 90 HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 134 GH+ + SL+++R G L ++ + +WD +G + + Sbjct: 61 RKLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREV 105 >4GGA-A nrPDB Length = 420 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 72/163 (44%), Gaps = 17/163 (10%) Query: 63 WSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFTSSMDES 119 WS G +A A D+ SV + S G + + P + S+ + ++GN L + Sbjct: 113 WS-SGNVLAVALDN-SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 170 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG-HCLKTLT 178 +++WD ++ +++HS V S+ +S ILSSGS G I D H + TL+ Sbjct: 171 VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLS 227 Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 + ++++ + R+L D +V +W G Sbjct: 228 GHSQ--------EVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 262 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 8/97 (8%) Query: 51 VTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-----LHTFIGHTAPVISLTF- 104 ++ H++ L W+PDG+ +A+ +D V + + G L TF H V ++ + Sbjct: 226 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 285 Query: 105 NRKGNLLFTS--SMDESIKIWDTLNGSLMKTISAHSE 139 + N+L T + D I+IW+ +G+ + + AHS+ Sbjct: 286 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 322 Score = 30.8 bits (68), Expect = 0.90, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 22/30 (73%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 GHT+ V+SLT + G + +++ DE++++W Sbjct: 362 GHTSRVLSLTMSPDGATVASAAADETLRLW 391 >5LCW-Q nrPDB Length = 374 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 72/163 (44%), Gaps = 17/163 (10%) Query: 63 WSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFTSSMDES 119 WS G +A A D+ SV + S G + + P + S+ + ++GN L + Sbjct: 67 WS-SGNVLAVALDN-SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 124 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG-HCLKTLT 178 +++WD ++ +++HS V S+ +S ILSSGS G I D H + TL+ Sbjct: 125 VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLS 181 Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 + ++++ + R+L D +V +W G Sbjct: 182 GHSQ--------EVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 216 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 8/97 (8%) Query: 51 VTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-----LHTFIGHTAPVISLTF- 104 ++ H++ L W+PDG+ +A+ +D V + + G L TF H V ++ + Sbjct: 180 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 239 Query: 105 NRKGNLLFTS--SMDESIKIWDTLNGSLMKTISAHSE 139 + N+L T + D I+IW+ +G+ + + AHS+ Sbjct: 240 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 276 Score = 30.8 bits (68), Expect = 0.87, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 22/30 (73%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 GHT+ V+SLT + G + +++ DE++++W Sbjct: 316 GHTSRVLSLTMSPDGATVASAAADETLRLW 345 >5G04-R nrPDB Length = 499 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 72/163 (44%), Gaps = 17/163 (10%) Query: 63 WSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFTSSMDES 119 WS G +A A D+ SV + S G + + P + S+ + ++GN L + Sbjct: 192 WS-SGNVLAVALDN-SVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE 249 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG-HCLKTLT 178 +++WD ++ +++HS V S+ +S ILSSGS G I D H + TL+ Sbjct: 250 VQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEHHVATLS 306 Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 + ++++ + R+L D +V +W G Sbjct: 307 GHSQ--------EVCGLRWAPDGRHLASGGNDNLVNVWPSAPG 341 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 8/97 (8%) Query: 51 VTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-----LLHTFIGHTAPVISLTF- 104 ++ H++ L W+PDG+ +A+ +D V + + G L TF H V ++ + Sbjct: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364 Query: 105 NRKGNLLFTS--SMDESIKIWDTLNGSLMKTISAHSE 139 + N+L T + D I+IW+ +G+ + + AHS+ Sbjct: 365 PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ 401 Score = 30.8 bits (68), Expect = 0.89, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 22/30 (73%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 GHT+ V+SLT + G + +++ DE++++W Sbjct: 441 GHTSRVLSLTMSPDGATVASAAADETLRLW 470 >5OQL-d nrPDB Length = 446 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 103/248 (41%), Gaps = 37/248 (14%) Query: 5 VTPVGT-QNGLKATCAKISPDGQFLAITQGLN-ILIYDINRRTVSQTLV-TSHARPFSEL 61 TP+ T Q G T A + G I I+D+ T Q + S +++ Sbjct: 144 TTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDV 203 Query: 62 CWSP-DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVIS---------LTFNRKGNL- 110 C++ + I + + D S+ + L + PVI + FN + Sbjct: 204 CFNQVETSVIGSVATDRSIILFDLRTNM---------PVIKTVLHFACNRIVFNPMEAMN 254 Query: 111 LFTSSMDESIKIWDTLN-GSLMKTISAHSEAVVSVDV-PMNDSSILSSGSYDGLIRIFDA 168 L +S D +I I+D N + H AV+ V+ P + L SGSYD IR++ Sbjct: 255 LAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEE--LVSGSYDRTIRLWRR 312 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIG---GCVVR 225 + GH + + + K +R + + ++ +++Y+L S DG V++W V Sbjct: 313 DAGHS-RDVYHTKRMQR------VFRTMWTMDSKYILTGSDDGNVRLWRANASERSGVKA 365 Query: 226 TFQVQPLE 233 T Q Q LE Sbjct: 366 TRQRQALE 373 Score = 37.0 bits (84), Expect = 0.010, Method: Compositional matrix adjust. Identities = 42/211 (19%), Positives = 78/211 (36%), Gaps = 46/211 (21%) Query: 98 PVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN--DSSILS 155 P SL+F+R N SS I+IWD + + + I S DV N ++S++ Sbjct: 155 PYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIG 214 Query: 156 SGSYDGLIRIFDAETG----------------------------------HCLKTLTYDK 181 S + D I +FD T + +DK Sbjct: 215 SVATDRSIILFDLRTNMPVIKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDK 274 Query: 182 DWKRENG-VVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS 240 + G V + V+FS L+ S D +++W G + + +++ V Sbjct: 275 ALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQR-VFRTM 333 Query: 241 CGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 MD + +++G ++G++ W ++ Sbjct: 334 WTMD--------SKYILTGSDDGNVRLWRAN 356 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 64/252 (25%), Positives = 102/252 (40%), Gaps = 28/252 (11%) Query: 69 CIATASDDFSVEIIHLSYGLLHTF--IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL 126 CIA+ S D V++ L+ T+ H V LTF LL S + IK+WD Sbjct: 81 CIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKKLL--SCATDGIKLWDPY 138 Query: 127 NGSLMKT-ISAHSEAVVSVDVPMNDSS-ILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 T I+ E + + S+ ++ S G IRI+D E + + + Sbjct: 139 ASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQW----- 193 Query: 185 RENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD 244 + V I+ V F++ + S+ G V I +RT P+ K VLH +C Sbjct: 194 -PSFVDTITDVCFNQ-----VETSVIGSVATDRSIILFDLRTNM--PVIKTVLHFACNRI 245 Query: 245 FLNPEDGSTPLVISGYENGDIYCWNSDT-KSLLQLLDGSLYHHSSPVMSIHC--FGNIMC 301 NP + V S E+ +IY +++ L + G H + VM + G + Sbjct: 246 VFNPMEAMNLAVAS--EDHNIYIFDARNFDKALNIQKG----HVAAVMDVEFSPTGEELV 299 Query: 302 SLALNGDCCLWR 313 S + + LWR Sbjct: 300 SGSYDRTIRLWR 311 >3JB9-S nrPDB Length = 488 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 7/127 (5%) Query: 23 PDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII 82 P G++L I+ + SQ + A+ + L PDG ++ + Sbjct: 305 PSGEYLLAASNEKCYIFSLK----SQVYNITVAQHITSLAVHPDGNLFVAGLENGELRFF 360 Query: 83 HLSYG-LLHTFIGHTAPVISLTFNRKGN-LLFTSSMDESIKIWDTLNGSLMKTISAHSE- 139 S G L F H++PV +L F G L+ T++ D I IWD L++ I ++ Sbjct: 361 ETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKV 420 Query: 140 AVVSVDV 146 A VS+D+ Sbjct: 421 AAVSLDI 427 >5WBU-D nrPDB Length = 328 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 32/154 (20%), Positives = 63/154 (40%), Gaps = 20/154 (12%) Query: 91 TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN- 149 ++ G + S+ F+ G ++T D + +IWD +++ + + + V+ P+N Sbjct: 82 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD------LRSRNLQCQRIFQVNAPINC 135 Query: 150 -----DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYL 204 + + L G G I I+D +T H + + + V I+ +A Y+ Sbjct: 136 VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE--------VSITSAHIDPDASYM 187 Query: 205 LVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLH 238 + G +W+ GG Q+ P K H Sbjct: 188 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAH 221 Score = 35.0 bits (79), Expect = 0.039, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 36/86 (41%), Gaps = 7/86 (8%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVD-------V 146 HT + F+ LL T S D++ KIW T N SLM +S S Sbjct: 220 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 279 Query: 147 PMNDSSILSSGSYDGLIRIFDAETGH 172 DS + + S D L R++ ETG Sbjct: 280 FSGDSQYIVTASSDNLARLWCVETGE 305 Score = 35.0 bits (79), Expect = 0.040, Method: Compositional matrix adjust. Identities = 35/152 (23%), Positives = 64/152 (42%), Gaps = 19/152 (12%) Query: 17 TCAKISPDGQFLAITQGL-NILIYDIN-------RRTVSQTLVTSHARPFSELCWSPDGQ 68 T A I PD ++A N ++++ + + +T + +H R + +SPD Sbjct: 176 TSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDST 235 Query: 69 CIATASDDFSVEIIHLSYGLLHTFI-------GHTAP--VISLTFNRKGNLLFTSSMDES 119 +AT S D + +I S L T + G ++ + F+ + T+S D Sbjct: 236 LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNL 295 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS 151 ++W G + + H +AVV + NDS Sbjct: 296 ARLWCVETGEIKREYGGHQKAVVC--LAFNDS 325 >3C9C-A nrPDB Length = 432 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/179 (26%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 54 HARPFSELCWSPD-GQCIATASDDFSV--------EIIHLSYGLLHTFIGHTAPVISLTF 104 H + L W+P+ + +ASDD ++ H + F GHTA V + + Sbjct: 182 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 241 Query: 105 NRKGNLLFTS-SMDESIKIWDTLNGSLMK---TISAHSEAVVSVDVPMNDSSILSSGSYD 160 + LF S + D+ + IWDT N + K T+ AH+ V + IL++GS D Sbjct: 242 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSAD 301 Query: 161 GLIRIFDAETGHC-LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKS-LDGVVKIWD 217 + ++D L + KD I QV++S + +L S D + +WD Sbjct: 302 KTVALWDLRNLKLKLHSFESHKD--------EIFQVQWSPHNETILASSGTDRRLHVWD 352 >5N4A-A nrPDB Length = 771 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/175 (25%), Positives = 73/175 (41%), Gaps = 26/175 (14%) Query: 58 FSELCWSP---------DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKG 108 F+++ W P A A D SV+I+ + + + GH ISL ++ G Sbjct: 57 FTDMHWYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRWSYDG 116 Query: 109 NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 L T+ D S+KIW + NG L T++ V S+ +YD + Sbjct: 117 TALATAGEDGSVKIW-SRNGMLRSTLAQADSPVYSI-----------VWAYDCDQLCYCT 164 Query: 169 ETGHCLKTLTYDKD---WKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIG 220 + +K+L+ + WK +GVV +V +S ++ D K+WD G Sbjct: 165 GSNVVIKSLSSNAKQNAWKAHDGVVL--KVDWSPINHLIITGGEDCKYKVWDSFG 217 >5CXC-A nrPDB Length = 510 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 36/123 (29%), Positives = 62/123 (50%), Gaps = 10/123 (8%) Query: 54 HARPFSELCWSPDGQCIA-TASDDFSVEIIHLSYGLLHTFIGHTAPVISLT-FNRKGN-- 109 H P + + P + +A +AS D +V + L+ G + + + T P++SL+ R G Sbjct: 311 HTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTS 370 Query: 110 -LLFTSSMDESIKIWDTLNGSL---MKTISAHSEAVVSVD-VPMNDSSILSSGSYDGLIR 164 LL + I + D S + T+ H+ VVS+ P N+ S++S GS+DG R Sbjct: 371 PLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVS-GSHDGTCR 429 Query: 165 IFD 167 ++D Sbjct: 430 VWD 432 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 32/146 (21%), Positives = 65/146 (44%), Gaps = 13/146 (8%) Query: 95 HTAPVISLTFN-RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSE--AVVSVDVPMNDS 151 HTAP + F+ R + +++S D +++ D G ++ T++ ++ ++ S Sbjct: 311 HTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTS 370 Query: 152 SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG 211 +L++G+ I + D ++ + N VV +S EN L+ S DG Sbjct: 371 PLLAAGTSARHITMVDPRASSATTSVMTLRG--HANKVVSLSPSP--ENEYSLVSGSHDG 426 Query: 212 VVKIWDCIGGCVVRTFQVQPLEKGVL 237 ++WD +R+ + E+G L Sbjct: 427 TCRVWD------LRSVRPATKEEGSL 446 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 40/162 (24%), Positives = 66/162 (40%), Gaps = 21/162 (12%) Query: 156 SGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 S SYDGL+RI++A +G + T I KF + R L +D V++ Sbjct: 163 SASYDGLLRIWNA-SGSVIAT---SPSGSHGGHTASIKAAKFLTSDR-LASAGMDRTVRV 217 Query: 216 W-----DCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 W D G + T + + H+ +D+L+ DG + +++ +G I W++ Sbjct: 218 WKYTESDHFTGELKPTLE-------LYGHTGSVDWLD-VDGHSKHILTASADGAIGFWSA 269 Query: 271 DTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 S + D SL + +S S A G LW Sbjct: 270 SKASAPE-PDASLLPGAH--VSKRRKATSSVSTAQRGPLGLW 308 >5K1B-B nrPDB Length = 677 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/122 (22%), Positives = 58/122 (47%), Gaps = 12/122 (9%) Query: 99 VISLTFNRKGNLLFTSSMDESIKIWDT---LNGSLMKTISAHSEAVVSVDVPMNDSSILS 155 V +L + N LFT+ D I+IW + ++ H++ V + + N +++S Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92 Query: 156 SGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 + S D +++++A G C+ TL KD+ + + ++++ + LD + + Sbjct: 93 ASS-DTTVKVWNAHKGFCMSTLRTHKDY--------VKALAYAKDKELVASAGLDRQIFL 143 Query: 216 WD 217 WD Sbjct: 144 WD 145 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 20/83 (24%), Positives = 44/83 (53%), Gaps = 1/83 (1%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 G+ + SL N+ G ++ + S ++ +++WD + + + H++ V ++ + + + Sbjct: 166 GNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQC 225 Query: 154 LSSGSYDGLIRIFDAETGHCLKT 176 L SGS DG IR++ C+ T Sbjct: 226 L-SGSSDGTIRLWSLGQQRCIAT 247 Score = 34.3 bits (77), Expect = 0.076, Method: Compositional matrix adjust. Identities = 29/120 (24%), Positives = 53/120 (44%), Gaps = 20/120 (16%) Query: 108 GNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 167 G L ++S D ++K+W+ G M T+ H + V ++ D +++S D I ++D Sbjct: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKAL-AYAKDKELVASAGLDRQIFLWD 145 Query: 168 AETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK----------SLDGVVKIWD 217 T L LT N V S + ++++ Y L S + V+++WD Sbjct: 146 VNT---LTALTA------SNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196 Score = 32.7 bits (73), Expect = 0.19, Method: Compositional matrix adjust. Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 3/80 (3%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPM 148 L GHT V +L NR G + S D +I++W + T H E V ++ V Sbjct: 203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQV-- 260 Query: 149 NDS-SILSSGSYDGLIRIFD 167 ND+ + + SG D I D Sbjct: 261 NDAFTHVYSGGRDRKIYCTD 280 >5WLC-LJ nrPDB Length = 513 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 77/174 (44%), Gaps = 14/174 (8%) Query: 28 LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP----DGQ--CIATASDDFSVEI 81 A+T + I+ R V +T F ++ +S DG+ C A+ SV Sbjct: 55 FAVTSSTRVQIFSSRTRQVIKTFSR-----FKDVVYSASFRSDGKLLCAGDATGLVSVYD 109 Query: 82 IHLSYGLLHTFIGHTAPVISLTFNRKGN-LLFTSSMDESIKIWDTLNGSLMK-TISAHSE 139 + +L + T P F+ + N +L T+S D ++WD N + ++ ++ Sbjct: 110 SYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATD 169 Query: 140 AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 193 V ++ ++++GSYDGLIR++D + + + D EN V+ +S Sbjct: 170 YVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVEN-VIAVS 222 >6CHG-D nrPDB Length = 439 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 6/73 (8%) Query: 14 LKATCAKISPDGQFLAI--TQGLNILIYDINRRTVSQTLVT---SHARPFSELCWSPDGQ 68 + A C K SP G +LA+ + G I+IYD++ L T +H R +CWS DG+ Sbjct: 28 VAAVCVKFSPRGDYLAVGCSNGA-IIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGR 86 Query: 69 CIATASDDFSVEI 81 + ++ D+ ++ Sbjct: 87 YLWSSGRDWYAKL 99 Score = 27.7 bits (60), Expect = 7.1, Method: Compositional matrix adjust. Identities = 22/104 (21%), Positives = 45/104 (43%), Gaps = 7/104 (6%) Query: 66 DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDES---IKI 122 D + +S S+E+ H +++ +T N G L S+ S + + Sbjct: 249 DNESEGGSSHSVSIELEHKYQDIINRLQWNTI----FFSNHSGEYLVASAHGSSAHDLYL 304 Query: 123 WDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 W+T +GSL++ + E ++ +D I S+G G + ++ Sbjct: 305 WETSSGSLVRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMW 348 >4YCZ-A nrPDB Length = 876 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 57/273 (20%), Positives = 105/273 (38%), Gaps = 35/273 (12%) Query: 67 GQCIATASDDFSVEIIHL---SYGLLHTFIGHTAPV--ISLTFNRKGNLLFTSSMDESIK 121 G+ +AT S D +++I + + L T GH V +S + GN+L ++ D + Sbjct: 30 GRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVL 89 Query: 122 IWDTLNGSLMK--TISAHSEAVVSVD-VPMNDSSILSSGSYDGLIRIFDAET-------- 170 IW LNG+ + + H +V V P +L+ S DG + + + Sbjct: 90 IWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIF 149 Query: 171 ---GHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 G + ++++ + V K + N R++ S D +KIW Sbjct: 150 HAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGS-DNALKIWAYDPATNTYKL 208 Query: 228 QVQPLEKGVLHHSCGMDFL-NPEDGSTPLVISGYENGDIYCWNSDTKSLLQL------LD 280 + +PL H D +P + S E+ + W SD + LQ D Sbjct: 209 EREPL---TGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFD 265 Query: 281 GSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWR 313 +++ +S GN++ + + LW+ Sbjct: 266 AAVWR-----VSWSLSGNVLAASGGDNKVTLWK 293 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 31/117 (26%), Positives = 50/117 (42%), Gaps = 16/117 (13%) Query: 33 GLNILIYD--INRRTVSQTLVTSHARPFSELCWSP---DGQCIATASDDFSVEII----- 82 L I YD N + + +T H ++ WSP IA+AS+D +V I Sbjct: 193 ALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPA 252 Query: 83 -HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW-DTLNGSL--MKTIS 135 L + + A V ++++ GN+L S D + +W + L G +KTI Sbjct: 253 NPLQWNC--KVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKTIE 307 Score = 28.1 bits (61), Expect = 5.1, Method: Compositional matrix adjust. Identities = 26/90 (28%), Positives = 40/90 (44%), Gaps = 5/90 (5%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS--LMKTISAHSEAV--VSVDVPMN 149 GH + + G L T S D +IKI++ + L +T+ H AV VS P Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKY 75 Query: 150 DSSILSSGSYDGLIRIFDAETGHCLKTLTY 179 +IL+S YDG + I+ G + + Sbjct: 76 -GNILASAGYDGKVLIWRELNGAWQRIFDF 104 >1PI6-A nrPDB Length = 615 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 34/194 (17%) Query: 108 GNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN--DSSILSSGSYDGLIRI 165 G + T D I +D +G +K I E V ++ DS ++ D IR+ Sbjct: 219 GEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRV 278 Query: 166 FDAETGHCLKTLTYDKDW--KRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCV 223 +D T C++ T DK ++ GVV N R + + SLDG + ++ V Sbjct: 279 WDVTTSKCVQKWTLDKQQLGNQQVGVVATG------NGRIISL-SLDGTLNFYELGHDEV 331 Query: 224 VRTFQVQPLEKGVLHHSCGMDFL--NPEDGSTPLVISGYENGDIYCWNS-----DTKSLL 276 ++T + H+ G+ L NP +ISG +G I W+S D +L+ Sbjct: 332 LKT---------ISGHNKGITALTVNP-------LISGSYDGRIMEWSSSSMHQDHSNLI 375 Query: 277 QLLDGSLYHHSSPV 290 LD S S + Sbjct: 376 VSLDNSKAQEYSSI 389 >5WYJ-BE nrPDB Length = 939 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 55/118 (46%), Gaps = 6/118 (5%) Query: 15 KATCAKISPDGQFLAITQ-GLNILI--YDINRRTVSQTLVTSHARPFSELCWSPDGQCIA 71 K IS DG + GL+ ++ YD N+ T+ L P + + + A Sbjct: 502 KRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDA--PITAMVYHRSSDLFA 559 Query: 72 TASDDFSVEIIH-LSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 A DD S+ +I ++ ++ GH+ + + F+ +G + ++S+D +I+ WD G Sbjct: 560 LALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTG 617 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 10/115 (8%) Query: 97 APVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSS 156 AP+ ++ ++R +L + D SI + D + +++ + HS + + D I+S+ Sbjct: 544 APITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSA 603 Query: 157 GSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG 211 S D IR +D TG C+ + D + VKFS N L + G Sbjct: 604 -SLDSTIRTWDLPTGGCIDGIIVDN---------VATNVKFSPNGDLLATTHVTG 648 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 61/159 (38%), Gaps = 35/159 (22%) Query: 99 VISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS 158 V S+ ++ GN F S + SI I++ +G L K H AV + + + ++S G Sbjct: 463 VKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCG- 521 Query: 159 YDGLIRIFDAETGHCLKTLTYDKD-----WKRENGVVP---------------------- 191 DG++ +D L L D + R + + Sbjct: 522 LDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQL 581 Query: 192 ------ISQVKFSENARYLLVKSLDGVVKIWDC-IGGCV 223 I+ FS R+++ SLD ++ WD GGC+ Sbjct: 582 WGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCI 620 >5BJS-A nrPDB Length = 605 Score = 37.0 bits (84), Expect = 0.010, Method: Compositional matrix adjust. Identities = 27/111 (24%), Positives = 48/111 (43%), Gaps = 10/111 (9%) Query: 110 LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 LL + + ++K+++ G L +T+ H + + + I++S S D IRI+ Sbjct: 150 LLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLA 209 Query: 170 TGH----CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW 216 H C+ L E + V F +N RY+L D V+ +W Sbjct: 210 PEHEKQPCVCILG------GEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 Score = 35.0 bits (79), Expect = 0.041, Method: Compositional matrix adjust. Identities = 31/126 (24%), Positives = 59/126 (46%), Gaps = 14/126 (11%) Query: 35 NILIYDINRRTVSQTLVTSHARPFSELCWSP-DGQCIATASDDFSVEIIHLSYGLLHTFI 93 N+ +Y++ + +TLV H ++L SP + IA+ASDD ++ I L+ Sbjct: 159 NVKVYNVTEGKLYRTLV-GHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPC 217 Query: 94 -------GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDV 146 GH+ ++S+ F+ G + ++ D+ I +W +L + + H E + + Sbjct: 218 VCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW-----ALPEFPNEHMEIPIVIYY 272 Query: 147 PMNDSS 152 P SS Sbjct: 273 PHFSSS 278 >5A9Q-7 nrPDB Length = 360 Score = 36.6 bits (83), Expect = 0.013, Method: Compositional matrix adjust. Identities = 33/144 (22%), Positives = 61/144 (42%), Gaps = 30/144 (20%) Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWD--------------TLNGSLMKTISAHSEA 140 H + ++F+ G + T S D+S+K+WD T +GS+ + AH E Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 141 VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV----PISQVK 196 +L+S S+D +++ G L W + +V ++ VK Sbjct: 71 ----------GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120 Query: 197 FSENARYLLVK--SLDGVVKIWDC 218 F+ L++ S DG+V+I++ Sbjct: 121 FAPKHMGLMLATCSADGIVRIYEA 144 Score = 31.2 bits (69), Expect = 0.67, Method: Compositional matrix adjust. Identities = 31/142 (21%), Positives = 63/142 (44%), Gaps = 19/142 (13%) Query: 46 VSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY-GLLH---TFIGHTAPVIS 101 V++++ H ++ + G+ +AT S D SV++ S G H ++ H+ V Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 102 LTFNRK--GNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDV------------- 146 +T+ G +L + S D + +W+ + G + S V + Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122 Query: 147 PMNDSSILSSGSYDGLIRIFDA 168 P + +L++ S DG++RI++A Sbjct: 123 PKHMGLMLATCSADGIVRIYEA 144 >6ELZ-p nrPDB Length = 460 Score = 36.6 bits (83), Expect = 0.015, Method: Compositional matrix adjust. Identities = 40/145 (27%), Positives = 69/145 (47%), Gaps = 8/145 (5%) Query: 95 HTAPVISLTFNRKGNLL-FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 HTAPV + F+ N + ++ S D +IK WD + + T + S +++S+ ++ ++ Sbjct: 286 HTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTT-SYSLLSI-AQLSTLNL 343 Query: 154 LSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVV 213 L+ GS I + D G K +T + +N V + EN L S DG V Sbjct: 344 LACGSSARHITLHDPRVGASSK-VTQQQLIGHKNFVSSLDTC--PENEYILCSGSHDGTV 400 Query: 214 KIWDCIGGCVVRTF--QVQPLEKGV 236 K+WD + T + + ++KGV Sbjct: 401 KVWDVRSTSPMYTITREDKSVQKGV 425 Score = 31.2 bits (69), Expect = 0.66, Method: Compositional matrix adjust. Identities = 28/117 (23%), Positives = 49/117 (41%), Gaps = 26/117 (22%) Query: 70 IATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN-- 127 I + S D V LS + + GH+ P+ ++ + L+ ++ D ++++W T N Sbjct: 118 IISGSYDGIVRTWDLSGNVQKQYSGHSGPIRAVKYISNTRLV-SAGNDRTLRLWKTKNDD 176 Query: 128 ---------------------GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLI 163 G + + H VVS+DV +D+S + S SYD I Sbjct: 177 LKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDV--SDNSRILSASYDNSI 231 Score = 28.5 bits (62), Expect = 3.8, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 53/121 (43%), Gaps = 18/121 (14%) Query: 141 VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN 200 V S+DV I+S GSYDG++R +D +G+ K + +G PI VK+ N Sbjct: 106 VSSLDVGDGSKHIIS-GSYDGIVRTWDL-SGNV------QKQYSGHSG--PIRAVKYISN 155 Query: 201 ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY 260 R L+ D +++W + L D +N EDG T ++ G+ Sbjct: 156 TR-LVSAGNDRTLRLWKTKNDDL-------KLTSQQQAQEDDDDEVNIEDGKTLAILEGH 207 Query: 261 E 261 + Sbjct: 208 K 208 >6IYY-A nrPDB Length = 317 Score = 35.8 bits (81), Expect = 0.024, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 40/83 (48%), Gaps = 6/83 (7%) Query: 134 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 193 I AH + + + + + I ++ LIRIFD +GH ++ L +R + I Sbjct: 172 IPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQEL------RRGSQAANIY 225 Query: 194 QVKFSENARYLLVKSLDGVVKIW 216 + F+++A + V S G V I+ Sbjct: 226 CINFNQDASLICVSSDHGTVHIF 248 >4G56-B nrPDB Length = 357 Score = 35.8 bits (81), Expect = 0.024, Method: Compositional matrix adjust. Identities = 39/146 (26%), Positives = 69/146 (47%), Gaps = 11/146 (7%) Query: 31 TQGLNILIYDINRRTVSQTLVTSHARP---FSELCWSPDGQCIATASDDFSVE---IIHL 84 T G +I ++ +++L T+ + +++ W + + I ASD +VE I+ Sbjct: 67 TWGGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSE-KGILVASDSGAVELWEILEK 125 Query: 85 SYGLLHTFIG--HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVV 142 L++ F H V +L+ G + D S+K+WD +++K+ +AHS V Sbjct: 126 ESLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVN 185 Query: 143 SVDV-PMNDSSILSSGSYDGLIRIFD 167 V P D+ LS G DG I ++D Sbjct: 186 CVAACPGKDTIFLSCGE-DGRILLWD 210 >4XFV-A nrPDB Length = 792 Score = 35.8 bits (81), Expect = 0.025, Method: Compositional matrix adjust. Identities = 39/184 (21%), Positives = 76/184 (41%), Gaps = 27/184 (14%) Query: 12 NGLKATCAKISPDGQFLAIT------QGLNILIYDINRRTVSQTLVTSHARPFSELCWSP 65 +G + TC ISPD + +A Q I I+ + + H+ + L +S Sbjct: 561 HGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSK 620 Query: 66 DGQCIATASDDFSVEI-----------IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS 114 DG+ + + D + + HT I A L F GN+ T+ Sbjct: 621 DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEF---GNVFVTA 677 Query: 115 SMDESIKIW----DTLNGSLMKTISAHSEAVVSV---DVPMNDSSILSSGSYDGLIRIFD 167 S D+++K+W + + +++ H++AV ++ D + + ++S G +G I ++ Sbjct: 678 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 737 Query: 168 AETG 171 G Sbjct: 738 YTLG 741 Score = 34.7 bits (78), Expect = 0.053, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 6/83 (7%) Query: 87 GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW---DTLNGSLMKTISAHSEAVVS 143 G+ T GH A V + F + + ++S D +KIW D + ++TI +S+ +V+ Sbjct: 54 GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVA 113 Query: 144 VDVPMNDSSILSSGSYDGLIRIF 166 + S++S G DG I I+ Sbjct: 114 LSAL---PSLISVGCADGTISIW 133 >4XYI-A nrPDB Length = 430 Score = 35.4 bits (80), Expect = 0.036, Method: Compositional matrix adjust. Identities = 35/134 (26%), Positives = 63/134 (47%), Gaps = 18/134 (13%) Query: 51 VTSHARPFSELCWSP-DGQCIATASDDFSVEIIHLSY--GLLHTFIGHTAPVISLTFNRK 107 V +H +P + + ++P + +ATAS D +V + L LHT GH V ++ ++ Sbjct: 277 VKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPH 336 Query: 108 GN-LLFTSSMDESIKIWD--------TLNGS------LMKTISAHSEAVVSVDVPMNDSS 152 +L TSS D + +WD T+ S LM H+ V + N+ Sbjct: 337 DEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKW 396 Query: 153 ILSSGSYDGLIRIF 166 +L+S + D +++I+ Sbjct: 397 VLASLADDNILQIW 410 >4BZK-B nrPDB Length = 297 Score = 35.0 bits (79), Expect = 0.038, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 92/224 (41%), Gaps = 29/224 (12%) Query: 108 GNLLFTSSMDESIKIWDTLNGS--LMKTISAHSEAVVSVDVPMND-SSILSSGSYDGLIR 164 G L T S D++IKI++ + L+ T++ H V VD +IL+S SYDG + Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 165 IFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVV 224 I+ E G + + N V Q E LLV S DG V + + Sbjct: 81 IWKEENGRWSQIAVHAVHSASVNSV----QWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 Query: 225 RTFQVQPLEKGVLHHSCGMDFLNPEDG-------STPLVISGYEN-GDIYCWNSDTKSLL 276 + GV S + EDG S V G +N I+ +NSD ++ Sbjct: 137 SPIIIDAHAIGVNSASWAPATIE-EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY- 194 Query: 277 QLLDGSLYHHS--------SPVMSIHCFGNIMCSLALNGDCCLW 312 +L+ +L HS SP + + + + S++ + C +W Sbjct: 195 -VLESTLEGHSDWVRDVAWSPTVLLRSY---LASVSQDRTCIIW 234 >3JRP-A nrPDB Length = 379 Score = 35.0 bits (79), Expect = 0.038, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 92/224 (41%), Gaps = 29/224 (12%) Query: 108 GNLLFTSSMDESIKIWDTLNGS--LMKTISAHSEAVVSVDVPMND-SSILSSGSYDGLIR 164 G L T S D++IKI++ + L+ T++ H V VD +IL+S SYDG + Sbjct: 23 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 82 Query: 165 IFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVV 224 I+ E G + + N V Q E LLV S DG V + + Sbjct: 83 IWKEENGRWSQIAVHAVHSASVNSV----QWAPHEYGPLLLVASSDGKVSVVEFKENGTT 138 Query: 225 RTFQVQPLEKGVLHHSCGMDFLNPEDG-------STPLVISGYEN-GDIYCWNSDTKSLL 276 + GV S + EDG S V G +N I+ +NSD ++ Sbjct: 139 SPIIIDAHAIGVNSASWAPATIE-EDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTY- 196 Query: 277 QLLDGSLYHHS--------SPVMSIHCFGNIMCSLALNGDCCLW 312 +L+ +L HS SP + + + + S++ + C +W Sbjct: 197 -VLESTLEGHSDWVRDVAWSPTVLLRSY---LASVSQDRTCIIW 236 >4BFG-A nrPDB Length = 216 Score = 35.0 bits (79), Expect = 0.045, Method: Compositional matrix adjust. Identities = 18/64 (28%), Positives = 32/64 (50%), Gaps = 11/64 (17%) Query: 17 TCAKISPDGQFLAITQGLNILIY-------DINRRTVSQTLVTSHARPFSELCWSPDGQC 69 TC ++P+G F L +L+ + NR V + + +P +++ WSPDG C Sbjct: 103 TCETVTPEGNFEK-NYDLQVLVPPEVTYFPEKNRSAVCEAMA---GKPAAQISWSPDGDC 158 Query: 70 IATA 73 + T+ Sbjct: 159 VTTS 162 >3JRO-A nrPDB Length = 753 Score = 34.3 bits (77), Expect = 0.065, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 95/238 (39%), Gaps = 29/238 (12%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS--LMKTISAHSEAVVSVDVPMND- 150 H + + G L T S D++IKI++ + L+ T++ H V VD Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 151 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLD 210 +IL+S SYDG + I+ E G + + N V Q E LLV S D Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV----QWAPHEYGPLLLVASSD 122 Query: 211 GVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG-------STPLVISGYEN- 262 G V + + + GV S + EDG S V G +N Sbjct: 123 GKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIE-EDGEHNGTKESRKFVTGGADNL 181 Query: 263 GDIYCWNSDTKSLLQLLDGSLYHHS--------SPVMSIHCFGNIMCSLALNGDCCLW 312 I+ +NSD ++ +L+ +L HS SP + + + + S++ + C +W Sbjct: 182 VKIWKYNSDAQTY--VLESTLEGHSDWVRDVAWSPTVLLRSY---LASVSQDRTCIIW 234 >5M89-A nrPDB Length = 329 Score = 33.5 bits (75), Expect = 0.11, Method: Compositional matrix adjust. Identities = 25/111 (22%), Positives = 46/111 (41%), Gaps = 11/111 (9%) Query: 91 TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMND 150 TF H PV L + G +L + +D+S +D G + +++A ++ D Sbjct: 125 TFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGE--RVARGYADAALTTCAFHPD 182 Query: 151 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA 201 ++ ++G+ G I +F T ++ PI + FSEN Sbjct: 183 GNLFAAGTQTGHILVFHTTTLEQAESFPLG---------TPIQALAFSENG 224 >5K19-A nrPDB Length = 569 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 19/57 (33%), Positives = 33/57 (57%), Gaps = 2/57 (3%) Query: 21 ISPDGQFLA-ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 SPDG+FLA ++Q + +++ + + T+ S+ +CWSPDG+ I T +D Sbjct: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTM-KSYFGGLLCVCWSPDGKYIVTGGED 283 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 28/137 (20%), Positives = 60/137 (43%), Gaps = 7/137 (5%) Query: 14 LKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLV--TSHARPFSELCWSPDGQCIA 71 ++ TC +P Q L QG + ++ ++ L+ T +E +SPDG+ +A Sbjct: 179 VEHTCGTTAPHYQLLK--QGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLA 236 Query: 72 TASDDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL 130 S D + + + LH T + ++ + ++ G + T D+ + +W ++ + Sbjct: 237 CVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRV 296 Query: 131 MKTISAHSE--AVVSVD 145 + H +VV+ D Sbjct: 297 IARGHGHKSWVSVVAFD 313 >5MC6-j nrPDB Length = 397 Score = 32.7 bits (73), Expect = 0.20, Method: Compositional matrix adjust. Identities = 30/123 (24%), Positives = 51/123 (41%), Gaps = 25/123 (20%) Query: 47 SQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII------------------HLSYGL 88 SQ + +++ + +SP G +A A D S I H S Sbjct: 225 SQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQAS 284 Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAH------SEAVV 142 L F H++ V+SL+FN G L ++ D ++ WD + T++ H E ++ Sbjct: 285 LGEF-AHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIEIEEDIL 343 Query: 143 SVD 145 +VD Sbjct: 344 AVD 346 >5LTD-A nrPDB Length = 525 Score = 32.7 bits (73), Expect = 0.20, Method: Compositional matrix adjust. Identities = 32/120 (26%), Positives = 60/120 (50%), Gaps = 9/120 (7%) Query: 35 NILIYDINRRTVSQT-LVTSHARPFSELCWSPDGQCIATASDDFS-VEIIHLSYGL-LHT 91 +++I+D +T+ T ++ +H + + S DG +ATASD + + + ++ G+ L+ Sbjct: 203 DVIIFDA--KTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQ 260 Query: 92 FIGHTAP--VISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI-SAHSEA-VVSVDVP 147 F T P + SL F+ + SS E++ I+ TI SA+ +A + VP Sbjct: 261 FRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSANKKARLTKAQVP 320 >5L9T-R nrPDB Length = 493 Score = 32.3 bits (72), Expect = 0.27, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 36/72 (50%), Gaps = 3/72 (4%) Query: 99 VISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS 158 V S+ ++ +GNL+ + ++IWD G + + H+ V ++ ++ LSSGS Sbjct: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW---NAEQLSSGS 288 Query: 159 YDGLIRIFDAET 170 D +I D T Sbjct: 289 RDRMILQRDIRT 300 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 40/84 (47%), Gaps = 2/84 (2%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 GH V L ++ LL + D + +W+ + S ++ + H AV ++ + + Sbjct: 311 GHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGL 370 Query: 154 LSS--GSYDGLIRIFDAETGHCLK 175 L+S G+ D IR ++ TG L+ Sbjct: 371 LASGGGTADRCIRFWNTLTGQPLQ 394 >5WLC-LW nrPDB Length = 554 Score = 32.0 bits (71), Expect = 0.33, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 31/59 (52%), Gaps = 2/59 (3%) Query: 97 APVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILS 155 PV S+ +R G + T+ D S+KIWD N + ++ S +V ++D+ +L+ Sbjct: 275 GPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHSVE--SLPTPGTNVSISDTGLLA 331 >3DW8-B nrPDB Length = 447 Score = 32.0 bits (71), Expect = 0.35, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 7/96 (7%) Query: 189 VVPISQVKFSENARYLLVKSLDGVVKIWDC-IGGCVVRTFQVQPLEKGVL----HHSCGM 243 + IS VKFS + RY++ + VK+WD + V T+QV + L + C Sbjct: 285 ISSISDVKFSHSGRYMMTRDYLS-VKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIF 343 Query: 244 D-FLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQL 278 D F +GS +V++G N ++ +TK + L Sbjct: 344 DKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITL 379 >4AV8-A nrPDB Length = 339 Score = 31.6 bits (70), Expect = 0.45, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 7/89 (7%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDES-IKIWDTLNGSLMKTISAHSEAVVSVDVPMN-DS 151 H PV + NRKG+++ T S D + I+++ T NG L++ + +D+ + D Sbjct: 177 AHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDG 236 Query: 152 SILSSGSYDGLIRIF----DAETG-HCLK 175 S L+ S + +F DAE H LK Sbjct: 237 SKLAVVSDKWTLHVFEVFNDAENKRHVLK 265 Score = 30.8 bits (68), Expect = 0.87, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 10/69 (14%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 ATC S DG + + Q N ++ RR + +T + ++ WSPDG +A SD Sbjct: 195 ATC---SQDGTLIRVFQTDNGVLVREFRRGLDRTSII-------DMRWSPDGSKLAVVSD 244 Query: 76 DFSVEIIHL 84 +++ + + Sbjct: 245 KWTLHVFEV 253 >5CXB-B nrPDB Length = 369 Score = 31.2 bits (69), Expect = 0.64, Method: Compositional matrix adjust. Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 2/69 (2%) Query: 92 FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHS-EAVVSVD-VPMN 149 F GH V S+ + G L T D ++++W+ L G + ++ + EAV +V P Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTK 76 Query: 150 DSSILSSGS 158 D+ IL++ + Sbjct: 77 DTFILAAAA 85 >3NTX-A nrPDB Length = 341 Score = 30.8 bits (68), Expect = 0.81, Method: Compositional matrix adjust. Identities = 13/28 (46%), Positives = 18/28 (64%) Query: 211 GVVKIWDCIGGCVVRTFQVQPLEKGVLH 238 GVV I+ I G VVR F +QP++ +L Sbjct: 216 GVVTIYPGISGAVVRNFLLQPVKALILR 243 >5FA5-B nrPDB Length = 367 Score = 30.8 bits (68), Expect = 0.86, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 5/103 (4%) Query: 70 IATASDDFSVEIIHLSYG---LLHTFIG--HTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 I ASD +VE+ L ++ F H V +++ G + S D IK+WD Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 125 TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 167 ++ + AH+ V V + S+ S S D I ++D Sbjct: 179 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWD 221 >3JZG-A nrPDB Length = 402 Score = 30.4 bits (67), Expect = 0.98, Method: Compositional matrix adjust. Identities = 20/87 (22%), Positives = 38/87 (43%), Gaps = 5/87 (5%) Query: 54 HARPFSELCWSP-DGQCIATASDDFSVEIIHLSYGLLHTFIG----HTAPVISLTFNRKG 108 H +EL + P D + + S D ++ + ++ L G H V+S ++ G Sbjct: 150 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 209 Query: 109 NLLFTSSMDESIKIWDTLNGSLMKTIS 135 + + MD S+K+W + +M I Sbjct: 210 EKIMSCGMDHSLKLWRINSKRMMNAIK 236 >4A11-B nrPDB Length = 408 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 46/116 (39%), Gaps = 19/116 (16%) Query: 31 TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI-ATASDDFSVEI--IHLSYG 87 T+G + + D+ + S L H + + WSP I ATAS D V++ + + G Sbjct: 163 TRGPKVQLCDLKSGSCSHIL-QGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASG 221 Query: 88 LLHTF---------------IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 L T H V L F G L T D +++W++ NG Sbjct: 222 CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 >5A9Q-0 nrPDB Length = 380 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 29/123 (23%), Positives = 54/123 (43%), Gaps = 13/123 (10%) Query: 101 SLTFNRKGNLLFTSSMDESIKIWDTLNG----SLMKTISAHSEAVVSVDVPMNDSSILSS 156 ++TF R +L +S+ + +KIWD S + +++ + VD N ++++ Sbjct: 177 AVTFLRTPEILTVNSIGQ-LKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVAT 235 Query: 157 GSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF-SENARYLLVKSLDGVVKI 215 G DG++ I+D G +L + + +V F N +L S DG + Sbjct: 236 GGQDGMLSIWDVRQGTMPVSLLKAHE-------AEMWEVHFHPSNPEHLFTCSEDGSLWH 288 Query: 216 WDC 218 WD Sbjct: 289 WDA 291 >4BFE-A nrPDB Length = 221 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 12/81 (14%) Query: 5 VTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYD-------INRRTVSQTLVTSHARP 57 ++ V Q+ TC ++P+G + L +L+ NR V + + +P Sbjct: 91 ISAVALQHEGTYTCEIVTPEGNLEKV-YDLQVLVPPEVTYFPGKNRTAVCEAMA---GKP 146 Query: 58 FSELCWSPDGQCIATASDDFS 78 +++ W+PDG C+ T S+ S Sbjct: 147 AAQISWTPDGDCV-TKSESHS 166 >1G73-A nrPDB Length = 162 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 16/74 (21%), Positives = 36/74 (48%), Gaps = 2/74 (2%) Query: 68 QCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLT--FNRKGNLLFTSSMDESIKIWDT 125 + ++ +D S ++ +Y L+ +T V +LT + + +LL + +E ++W Sbjct: 21 RAVSLVTDSTSTDLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQV 80 Query: 126 LNGSLMKTISAHSE 139 + G+ + S H E Sbjct: 81 IIGARAEMTSKHQE 94 >2VNU-D nrPDB Length = 760 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 26/77 (33%), Positives = 34/77 (44%), Gaps = 6/77 (7%) Query: 237 LHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDG--SLYHHSSPVMSIH 294 L DF PE ST V+ G +NG +Y N S L+G SL S PV+ + Sbjct: 4 LERDTFSDFTFPEYYSTARVMGGLKNGVLYQGNIQI-SEYNFLEGSVSLPRFSKPVLIV- 61 Query: 295 CFGNIMCSLALNGDCCL 311 G + A NGD + Sbjct: 62 --GQKNLNRAFNGDQVI 76 >3W15-A nrPDB Length = 368 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 4/75 (5%) Query: 92 FIGHTAPVISLTFN--RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN 149 F H V S +N + N L +SS D SIKIW L + T++ + + P+N Sbjct: 102 FKEHEREVFSCNWNLVNRQNFL-SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN 160 Query: 150 DSSILSSGSYDGLIR 164 + IL S+ G+ + Sbjct: 161 -AIILKKKSFTGISK 174 Score = 28.9 bits (63), Expect = 2.8, Method: Compositional matrix adjust. Identities = 39/139 (28%), Positives = 60/139 (43%), Gaps = 23/139 (16%) Query: 42 NRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTA-PV 99 NR V Q + H + L S G A+ D I L G + F+ H+ Sbjct: 175 NRNCVYQAQFSPHDQ---NLVLSCSGNSYASLFD------IRLPSGKNQNNFLVHSGLEA 225 Query: 100 ISLTFNR-KGNLLFTSSMDESIKIWDTL----------NGSLMKTI-SAHSEAVVSVDVP 147 ++ FN+ + ++ T +D +I+IWD N S + I +AH A+ V Sbjct: 226 LTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWS 285 Query: 148 MNDSSILSSGSYDGLIRIF 166 + S+IL S SYD RI+ Sbjct: 286 PHHSNILMSASYDMTCRIW 304 >3HZH-A nrPDB Length = 157 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 35/61 (57%), Gaps = 4/61 (6%) Query: 177 LTYDKDWKRENGVVPISQV-KFSENARYLLVKSLDGVVKIWDC-IGGCVVRTFQVQPLEK 234 +T D + +G+ +S + +F +NAR +++ +L + DC I G +TF V+PL++ Sbjct: 87 VTLDITMPKMDGITCLSNIMEFDKNARVIMISALGKEQLVKDCLIKGA--KTFIVKPLDR 144 Query: 235 G 235 Sbjct: 145 A 145 >4R40-A nrPDB Length = 411 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 28/62 (45%), Gaps = 6/62 (9%) Query: 18 CAKISPDGQFLAI----TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 SPDG LA + LN+ + D+ +SQ VT +E W PD Q +A Sbjct: 229 APAFSPDGTKLAFALSKSGSLNLYVMDLASGQISQ--VTDGRSNNTEPSWFPDSQNLAYT 286 Query: 74 SD 75 SD Sbjct: 287 SD 288 >5YZG-2 nrPDB Length = 646 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 16/29 (55%) Query: 61 LCWSPDGQCIATASDDFSVEIIHLSYGLL 89 +C+SPDG+ IAT D V I G L Sbjct: 286 VCFSPDGKKIATIGSDRKVRIFRFVTGKL 314 >3EI3-B nrPDB Length = 383 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 4/78 (5%) Query: 95 HTAPVISLTFNRKGN-LLFTSSMDESIKIWDTLNGSLMKTISA---HSEAVVSVDVPMND 150 H A V FN + + L+ TSS+D ++K+WD N + A H + V + D Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTD 262 Query: 151 SSILSSGSYDGLIRIFDA 168 S+ L + IR++ + Sbjct: 263 STKLLTTDQRNEIRVYSS 280 >5JVV-B nrPDB Length = 298 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 51/129 (39%), Gaps = 16/129 (12%) Query: 23 PDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII 82 PD + I +G+N T SQ + H + E+ S D Q T S+ S Sbjct: 112 PDDGEIDIIEGVN---------TQSQNTMVLHTKGNCEIT-SDDDQTGTTTSNQCS---- 157 Query: 83 HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSS-MDESIKIWDTLNGSLMKTISAHSEAV 141 L G + T +FN +G ++ DE IK+W ++ K+I + S V Sbjct: 158 -LDAGPAGCVVQGTPGSYGSSFNEQGGGVYAMQWTDEFIKLWFFPRSAIPKSIESDSPDV 216 Query: 142 VSVDVPMND 150 PM + Sbjct: 217 SEFGTPMGN 225 >2ECF-A nrPDB Length = 741 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 21/86 (24%), Positives = 36/86 (41%), Gaps = 15/86 (17%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDI--NRRT-------------VSQTLVTSHARPFSE 60 AT AK+SP G F++ +G N+ + D+ R+ +++ + + Sbjct: 154 ATDAKLSPKGGFVSFIRGRNLWVIDLASGRQMQLTADGSTTIGNGIAEFVADEEMDRHTG 213 Query: 61 LCWSPDGQCIATASDDFSVEIIHLSY 86 W+PD IA A D S + Y Sbjct: 214 YWWAPDDSAIAYARIDESPVPVQKRY 239 >6CB1-s nrPDB Length = 569 Score = 28.1 bits (61), Expect = 4.7, Method: Compositional matrix adjust. Identities = 12/37 (32%), Positives = 21/37 (56%) Query: 92 FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 + GH V +L+ + G L T S D ++++W+ L G Sbjct: 195 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTG 231 >5AMS-A nrPDB Length = 431 Score = 28.1 bits (61), Expect = 5.0, Method: Compositional matrix adjust. Identities = 39/180 (21%), Positives = 69/180 (38%), Gaps = 9/180 (5%) Query: 91 TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHS---EAVVSVDVP 147 T G+ VIS +F +G L T+ M + + G +++ E +V + Sbjct: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 Query: 148 MNDSSILSSGSYDGLIRIFDA-ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLV 206 + + G+ DG + + E L+ L +++ + EN L+ Sbjct: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 Query: 207 KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPE---DGSTPLVISGYENG 263 SLD + W+C G + F++ E L L PE G++ +V G NG Sbjct: 224 CSLDSTIVAWNCFTG--QQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNG 281 >6C0F-s nrPDB Length = 807 Score = 28.1 bits (61), Expect = 5.3, Method: Compositional matrix adjust. Identities = 12/37 (32%), Positives = 21/37 (56%) Query: 92 FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 + GH V +L+ + G L T S D ++++W+ L G Sbjct: 433 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTG 469 >6EM1-m nrPDB Length = 807 Score = 28.1 bits (61), Expect = 5.4, Method: Compositional matrix adjust. Identities = 12/37 (32%), Positives = 21/37 (56%) Query: 92 FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 + GH V +L+ + G L T S D ++++W+ L G Sbjct: 433 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTG 469 >4TX5-A nrPDB Length = 192 Score = 27.7 bits (60), Expect = 6.3, Method: Compositional matrix adjust. Identities = 16/74 (21%), Positives = 35/74 (47%), Gaps = 2/74 (2%) Query: 68 QCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLT--FNRKGNLLFTSSMDESIKIWDT 125 + ++ +D S + +Y L+ +T V +LT + + +LL + +E ++W Sbjct: 21 RAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQV 80 Query: 126 LNGSLMKTISAHSE 139 + G+ + S H E Sbjct: 81 IIGARAEMTSKHQE 94 >1H5Q-A nrPDB Length = 265 Score = 27.3 bits (59), Expect = 8.1, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%) Query: 102 LTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVS 143 L +KG+++ TSSM I +LNGSL + S+A S Sbjct: 139 LQKQQKGSIVVTSSMSSQIINQSSLNGSLTQVFYNSSKAACS 180 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6BX3-A nrPDB 393 e-110 6CHG-A nrPDB 286 7e-78 5M25-A nrPDB 255 2e-68 2H9P-A nrPDB 244 4e-65 5MZH-A nrPDB 224 4e-59 5NNZ-B nrPDB 220 6e-58 1VYH-C nrPDB 203 1e-52 6MZM-G nrPDB 199 1e-51 6F3T-A nrPDB 196 1e-50 6Q8F-A nrPDB 194 5e-50 6QX9-5O nrPDB 191 3e-49 6HQA-B nrPDB 190 5e-49 6ID0-T nrPDB 189 1e-48 5GAN-H nrPDB 186 1e-47 3MKQ-A nrPDB 184 3e-47 3DM0-A nrPDB 181 5e-46 2YNP-A nrPDB 179 2e-45 5NZU-C nrPDB 174 6e-44 5FL8-q nrPDB 173 1e-43 6N9G-C nrPDB 168 3e-42 6QX9-4B nrPDB 168 3e-42 6G51-g nrPDB 166 8e-42 4V7E-Bg nrPDB 166 9e-42 5OPT-p nrPDB 162 2e-40 5WLC-LO nrPDB 160 6e-40 4V6W-Ag nrPDB 159 2e-39 4V8M-A7 nrPDB 158 2e-39 5I2T-A nrPDB 158 3e-39 3FM0-A nrPDB 156 1e-38 5Y88-O nrPDB 155 2e-38 5UZ7-B nrPDB 155 2e-38 5Z56-q nrPDB 154 4e-38 5OQL-L nrPDB 154 5e-38 3JB9-L nrPDB 153 1e-37 3JB9-g nrPDB 151 4e-37 5WYJ-BC nrPDB 150 9e-37 4LG8-A nrPDB 148 3e-36 6HHQ-h nrPDB 147 5e-36 4AEZ-A nrPDB 144 4e-35 5YZG-W nrPDB 142 1e-34 6GMH-W nrPDB 142 1e-34 6QDV-o nrPDB 142 2e-34 5OQL-d nrPDB 142 2e-34 6E29-D nrPDB 141 4e-34 3JAP-g nrPDB 141 5e-34 5G04-R nrPDB 140 1e-33 6EOJ-D nrPDB 138 3e-33 3C9C-A nrPDB 137 6e-33 4GGA-A nrPDB 136 1e-32 4J0W-A nrPDB 135 2e-32 5LCW-Q nrPDB 134 4e-32 6J6H-n nrPDB 132 1e-31 5OQL-J nrPDB 132 1e-31 5WYK-BB nrPDB 132 2e-31 5OV3-A nrPDB 132 2e-31 4U1E-I nrPDB 130 9e-31 4N14-A nrPDB 129 2e-30 4BTS-AR nrPDB 129 2e-30 2HES-X nrPDB 129 2e-30 6EMK-B nrPDB 126 9e-30 2AQ5-A nrPDB 126 2e-29 5FVM-C nrPDB 125 3e-29 5XYI-g nrPDB 122 2e-28 3ACP-A nrPDB 119 1e-27 3ODT-A nrPDB 119 2e-27 5K0Y-T nrPDB 116 1e-26 6BX3-B nrPDB 116 2e-26 5OQL-X nrPDB 113 1e-25 3BG0-A nrPDB 112 3e-25 5WBU-D nrPDB 111 5e-25 5MWJ-A nrPDB 111 5e-25 5N4A-A nrPDB 108 3e-24 5WLC-LU nrPDB 104 6e-23 4OWR-A nrPDB 98 7e-21 1NR0-A nrPDB 95 3e-20 3JB9-S nrPDB 67 1e-11 Sequences not found previously or not previously below threshold: 5Y1U-A nrPDB 133 8e-32 3CFV-B nrPDB 129 1e-30 5L9T-R nrPDB 129 2e-30 5K1B-B nrPDB 128 3e-30 4YCZ-A nrPDB 126 1e-29 5WJC-A nrPDB 125 3e-29 4XYI-A nrPDB 119 2e-27 5A31-R nrPDB 113 1e-25 4L9O-A nrPDB 112 2e-25 3JRO-A nrPDB 112 2e-25 4BH6-A nrPDB 111 5e-25 4A11-B nrPDB 109 1e-24 3JRP-A nrPDB 104 6e-23 5WLC-LJ nrPDB 103 1e-22 4BZK-B nrPDB 100 6e-22 6ELZ-p nrPDB 98 3e-21 6CHG-D nrPDB 97 1e-20 3W15-A nrPDB 96 2e-20 5WYJ-BE nrPDB 94 5e-20 4E5Z-B nrPDB 90 1e-18 3JZG-A nrPDB 89 2e-18 5CXC-A nrPDB 89 2e-18 4G56-B nrPDB 89 2e-18 4XFV-A nrPDB 88 5e-18 4PSX-B nrPDB 87 1e-17 6F1U-h nrPDB 84 1e-16 5WLC-SG nrPDB 83 1e-16 5A9Q-7 nrPDB 83 1e-16 4J0X-A nrPDB 83 2e-16 2PM9-A nrPDB 80 1e-15 5FA5-B nrPDB 80 2e-15 6EM1-m nrPDB 78 4e-15 5BJS-A nrPDB 78 5e-15 6C0F-s nrPDB 78 5e-15 6CB1-s nrPDB 78 6e-15 1PI6-A nrPDB 77 1e-14 5K19-A nrPDB 74 6e-14 5M89-A nrPDB 74 7e-14 3F3P-A nrPDB 74 8e-14 5A9Q-2 nrPDB 74 1e-13 5WLC-LN nrPDB 72 3e-13 5YZG-2 nrPDB 72 3e-13 5A9Q-0 nrPDB 72 3e-13 2P9P-C nrPDB 71 4e-13 5WLC-LW nrPDB 71 9e-13 5CXB-B nrPDB 70 2e-12 5AMS-A nrPDB 68 4e-12 3I2N-A nrPDB 64 6e-11 3EI3-B nrPDB 64 9e-11 5MC6-j nrPDB 63 2e-10 3DW8-B nrPDB 62 4e-10 6IYY-A nrPDB 59 3e-09 5LTD-A nrPDB 59 3e-09 3DWL-C nrPDB 55 4e-08 6CVZ-A nrPDB 55 5e-08 5AJA-A nrPDB 54 1e-07 5TF2-A nrPDB 52 3e-07 6N8P-A nrPDB 51 6e-07 5WLC-LH nrPDB 51 8e-07 2I3T-A nrPDB 49 2e-06 5K1H-B nrPDB 49 3e-06 5WLC-LV nrPDB 48 4e-06 4AV8-A nrPDB 48 5e-06 2VDU-B nrPDB 48 5e-06 5WLC-LS nrPDB 43 2e-04 2EEP-A nrPDB 42 4e-04 5OLJ-A nrPDB 42 4e-04 4FHN-A nrPDB 42 5e-04 4R40-A nrPDB 41 7e-04 3WJ9-A nrPDB 39 0.004 4YHC-A nrPDB 39 0.004 5BPW-A nrPDB 37 0.015 1C5K-A nrPDB 36 0.022 4NOX-A nrPDB 36 0.024 5CWW-B nrPDB 36 0.025 6IGB-A nrPDB 36 0.026 5GRS-A nrPDB 36 0.027 5BPT-A nrPDB 36 0.027 3FGB-A nrPDB 36 0.032 6FYY-p nrPDB 34 0.070 2XE4-A nrPDB 34 0.080 5WLC-LL nrPDB 33 0.14 2ZZK-A nrPDB 32 0.23 4U1F-A nrPDB 32 0.28 6IGR-A nrPDB 32 0.33 3MWP-A nrPDB 32 0.39 2ECF-A nrPDB 31 0.58 3R3L-A nrPDB 31 0.77 5TXC-A nrPDB 31 0.85 6BN7-A nrPDB 30 1.3 4LA1-A nrPDB 30 1.5 4DGS-A nrPDB 30 1.6 2X8H-A nrPDB 30 1.7 3CLR-C nrPDB 30 1.9 4BP8-A nrPDB 29 2.2 3AZQ-A nrPDB 29 3.0 5YP1-A nrPDB 29 3.3 5SUM-A nrPDB 29 4.1 4H0U-A nrPDB 28 4.9 1YJS-A nrPDB 28 5.4 4KQP-A nrPDB 28 5.9 >6BX3-A nrPDB Length = 314 Score = 393 bits (1010), Expect = e-110, Method: Composition-based stats. Identities = 314/314 (100%), Positives = 314/314 (100%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL Sbjct: 1 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL 60 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 121 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK Sbjct: 61 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 120 Query: 122 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 181 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK Sbjct: 121 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 180 Query: 182 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC Sbjct: 181 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 240 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC 301 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC Sbjct: 241 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC 300 Query: 302 SLALNGDCCLWRWV 315 SLALNGDCCLWRWV Sbjct: 301 SLALNGDCCLWRWV 314 >6CHG-A nrPDB Length = 312 Score = 286 bits (732), Expect = 7e-78, Method: Composition-based stats. Identities = 167/314 (53%), Positives = 226/314 (71%), Gaps = 5/314 (1%) Query: 1 MFQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSE 60 M QF V +G +T +ISPDG+ +AI Q ++L+Y+I+ + + L T+H + Sbjct: 1 MLQFDKQVLPASGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMK-LTTTHKECINC 59 Query: 61 LCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESI 120 LCWSPD +CIA+ S+DF+VEI H+ YG + +GHTAPVIS+ +N KGN+L +SSMDESI Sbjct: 60 LCWSPDSKCIASGSEDFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESI 119 Query: 121 KIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYD 180 K W L+G+ +KT+SAHS+AVVS+D+P DSSILSSGSYDGLIRIFD E+GHCLKTLTYD Sbjct: 120 KEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYD 179 Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE-KGVLHH 239 KDW E+GVVPIS VKFS N ++LLVKSLD VVK+W+ G VVRTF E K L + Sbjct: 180 KDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKY 239 Query: 240 SCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNI 299 +CG++ + P G PLVISG ++G + WN +K+L+Q +D H +SP++SI + Sbjct: 240 NCGLELIYP-QGKDPLVISGNDSGSMCVWNVYSKNLVQKIDE--KHRNSPLISISASYDK 296 Query: 300 MCSLALNGDCCLWR 313 + +L+LNG+C L+R Sbjct: 297 VATLSLNGECNLFR 310 Score = 79.0 bits (193), Expect = 2e-15, Method: Composition-based stats. Identities = 35/221 (15%), Positives = 80/221 (36%), Gaps = 26/221 (11%) Query: 100 ISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSY 159 S + G L+ + + +++ + +MK + H E + + DS ++SGS Sbjct: 17 TSCQISPDGELIAICQNTDML-VYEISSSKMMKLTTTHKECINCL-CWSPDSKCIASGSE 74 Query: 160 DGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI 219 D + I + Y + + P+ + ++ L S+D +K W + Sbjct: 75 DFTVEI---------THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVL 125 Query: 220 GGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLL 279 G ++T HS + ++ + ++ SG +G I +++++ L+ L Sbjct: 126 SGTALKTMS---------AHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTL 176 Query: 280 D------GSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWRW 314 + G + +L+ LW + Sbjct: 177 TYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEY 217 >5M25-A nrPDB Length = 434 Score = 255 bits (650), Expect = 2e-68, Method: Composition-based stats. Identities = 111/323 (34%), Positives = 162/323 (50%), Gaps = 33/323 (10%) Query: 5 VTPVGTQNGLKAT---------CAKISPDGQFLAIT-QGLNILIYDINRRTVSQTLVTSH 54 TPV LK T K SP+G++LA + I I+ +T+ + H Sbjct: 128 PTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGH 186 Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFT 113 S++ WS D + +ASDD +++I +S G L T GH+ V FN + NL+ + Sbjct: 187 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 246 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 173 S DES++IWD G +KT+ AHS+ V +V D S++ S SYDGL RI+D +G C Sbjct: 247 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQC 305 Query: 174 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 LKTL D + P+S VKFS N +Y+L +LD +K+WD G ++T+ E Sbjct: 306 LKTLIDDDNP-------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 358 Query: 234 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 293 K + F N ++SG E+ +Y WN TK ++Q L G H+ V+S Sbjct: 359 KYCI-------FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG----HTDVVIST 407 Query: 294 --HCFGNIMCSLALNGDCCLWRW 314 H NI+ S AL D + W Sbjct: 408 ACHPTENIIASAALENDKTIKLW 430 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 108/271 (39%), Gaps = 17/271 (6%) Query: 3 QFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELC 62 +F + + A S ++ + + I+D++ +TL H+ Sbjct: 178 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-GHSNYVFCCN 236 Query: 63 WSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 121 ++P I + S D SV I + G L T H+ PV ++ FNR G+L+ +SS D + Sbjct: 237 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 296 Query: 122 IWDTLNGSLMKTISAHSE-AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYD 180 IWDT +G +KT+ V V N IL++ + D ++++D G CLKT T Sbjct: 297 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGH 355 Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS 240 K+ K I ++++ S D +V IW+ +V+ Q Sbjct: 356 KNEKYC-----IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 410 Query: 241 CGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 + + + I W SD Sbjct: 411 PTENIIASAALE--------NDKTIKLWKSD 433 >2H9P-A nrPDB Length = 329 Score = 244 bits (622), Expect = 4e-65, Method: Composition-based stats. Identities = 111/323 (34%), Positives = 162/323 (50%), Gaps = 33/323 (10%) Query: 5 VTPVGTQNGLKAT---------CAKISPDGQFLAIT-QGLNILIYDINRRTVSQTLVTSH 54 TPV LK T K SP+G++LA + I I+ +T+ + H Sbjct: 23 PTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGH 81 Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFT 113 S++ WS D + +ASDD +++I +S G L T GH+ V FN + NL+ + Sbjct: 82 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 141 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 173 S DES++IWD G +KT+ AHS+ V +V D S++ S SYDGL RI+D +G C Sbjct: 142 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQC 200 Query: 174 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 LKTL D + P+S VKFS N +Y+L +LD +K+WD G ++T+ E Sbjct: 201 LKTLIDDDNP-------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 253 Query: 234 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 293 K + F N ++SG E+ +Y WN TK ++Q L G H+ V+S Sbjct: 254 KYCI-------FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG----HTDVVIST 302 Query: 294 --HCFGNIMCSLALNGDCCLWRW 314 H NI+ S AL D + W Sbjct: 303 ACHPTENIIASAALENDKTIKLW 325 Score = 162 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 108/271 (39%), Gaps = 17/271 (6%) Query: 3 QFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELC 62 +F + + A S ++ + + I+D++ +TL H+ Sbjct: 73 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-GHSNYVFCCN 131 Query: 63 WSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 121 ++P I + S D SV I + G L T H+ PV ++ FNR G+L+ +SS D + Sbjct: 132 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 191 Query: 122 IWDTLNGSLMKTISAHSE-AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYD 180 IWDT +G +KT+ V V N IL++ + D ++++D G CLKT T Sbjct: 192 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGH 250 Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS 240 K+ K I ++++ S D +V IW+ +V+ Q Sbjct: 251 KNEKYC-----IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 305 Query: 241 CGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 + + + I W SD Sbjct: 306 PTENIIASAALE--------NDKTIKLWKSD 328 >5MZH-A nrPDB Length = 452 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 121/313 (38%), Gaps = 31/313 (9%) Query: 8 VGTQNGLKATCAKISPDGQF----LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCW 63 V T G K I+ + + + + ++D + TL H L + Sbjct: 129 VFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLK-GHQTEIVCLSF 187 Query: 64 SPDGQCIATASDDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 +P IAT S D + ++ + G T GH A ++SL FN G+L+ T S D ++ Sbjct: 188 NPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRL 247 Query: 123 WDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 WD G + +S H V S +++ SGS D R++D +G CL D Sbjct: 248 WDVRTGQCVHVLSGHRGEVSSTQFNYA-GTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTD 306 Query: 183 WKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCG 242 + V F ++ S DG +++ + G T E + + Sbjct: 307 --------EVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNP- 357 Query: 243 MDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMS--IHCFGNIM 300 +I+ + W+ DT LQ+L+G H+ + S + G+ + Sbjct: 358 ---------QGTRLITASSDKTCRLWDCDTGECLQVLEG----HTDEIFSCAFNYEGDFI 404 Query: 301 CSLALNGDCCLWR 313 + + + C +W+ Sbjct: 405 ITGSKDNTCRIWK 417 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 105/269 (39%), Gaps = 24/269 (8%) Query: 10 TQNGLKAT--CAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD 66 T G + C +P +A + ++D+ TL H L ++ Sbjct: 174 TLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLA-GHRAEIVSLGFNTG 232 Query: 67 GQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT 125 G I T S D + + G +H GH V S FN G L+ + S+D + ++WD Sbjct: 233 GDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDV 292 Query: 126 LNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKR 185 +G + H++ V+ V + + S S DG R++ TG C TL + Sbjct: 293 RSGRCLSVKQGHTDEVLDVAFDAAGTK-MVSASADGSARLYHTLTGVCQHTLVGHEG--- 348 Query: 186 ENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF 245 IS+V F+ L+ S D ++WDC G ++ + E SC ++ Sbjct: 349 -----EISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDE----IFSCAFNY 399 Query: 246 LNPEDGSTPLVISGYENGDIYCWNSDTKS 274 +I+G ++ W + T S Sbjct: 400 ------EGDFIITGSKDNTCRIWKALTAS 422 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 59/268 (22%), Positives = 105/268 (39%), Gaps = 27/268 (10%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLH-TFIGHTAPVISLTF-NR 106 ++ +H P + ++ G T S D + ++ + G T GH V ++ F N Sbjct: 88 KVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNP 147 Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 G+ + T S D++ K+WD G L T+ H +V + S+I+++GS D +++ Sbjct: 148 YGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNP-QSTIIATGSMDNTAKLW 206 Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 D ETG TL + I + F+ ++ S D ++WD G V Sbjct: 207 DVETGQERATLAGHR--------AEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHV 258 Query: 227 FQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHH 286 E + LV+SG + W+ + L + G H Sbjct: 259 LSGHRGEVSSTQFNYA----------GTLVVSGSIDCTSRLWDVRSGRCLSVKQG----H 304 Query: 287 SSPVMSIHCF--GNIMCSLALNGDCCLW 312 + V+ + G M S + +G L+ Sbjct: 305 TDEVLDVAFDAAGTKMVSASADGSARLY 332 Score = 157 bits (396), Expect = 7e-39, Method: Composition-based stats. Identities = 53/237 (22%), Positives = 94/237 (39%), Gaps = 20/237 (8%) Query: 76 DFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 D +E H S+ L H P+ + FN+ G+ T S D + K+W+T G + T+ Sbjct: 74 DKMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLE 133 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 H V ++ + +GS+D +++DA TG TL + I + Sbjct: 134 GHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQ--------TEIVCL 185 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 F+ + + S+D K+WD G T E L + G D L Sbjct: 186 SFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGD----------L 235 Query: 256 VISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 +++G + D W+ T + +L G + + G ++ S +++ LW Sbjct: 236 IVTGSFDHDSRLWDVRTGQCVHVLSG--HRGEVSSTQFNYAGTLVVSGSIDCTSRLW 290 Score = 87.9 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 30/126 (23%), Positives = 53/126 (42%), Gaps = 5/126 (3%) Query: 8 VGTQNGLKATCAKISPDG---QFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWS 64 + + G ++ D + ++ + + +Y TLV H S++ ++ Sbjct: 298 LSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLV-GHEGEISKVAFN 356 Query: 65 PDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 P G + TAS D + + G L GHT + S FN +G+ + T S D + +IW Sbjct: 357 PQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIW 416 Query: 124 DTLNGS 129 L S Sbjct: 417 KALTAS 422 >5NNZ-B nrPDB Length = 415 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 126/313 (40%), Gaps = 31/313 (9%) Query: 8 VGTQNGLKATCAKI---SPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCW 63 + T G + I +P G +A ++ + T H L + Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTF-RGHTAEIVCLSF 185 Query: 64 SPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 +P +AT S D + ++ + G ++T GH+A +ISL+FN G+ + T S D ++ + Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVV 245 Query: 123 WDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 WD G + + H + S D S++ +GS D +++DA G C+ TLT D Sbjct: 246 WDADTGRKVNILIGHCAEISSASFNW-DCSLILTGSMDKTCKLWDATNGKCVATLTGHDD 304 Query: 183 WKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCG 242 I F + + S DG +I+ + + E + + Sbjct: 305 --------EILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNP- 355 Query: 243 MDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMS--IHCFGNIM 300 +++G + W++ T LQ+L+G H+ + S + GNI+ Sbjct: 356 ---------QGNHLLTGSSDKTARIWDAQTGQCLQVLEG----HTDEIFSCAFNYKGNIV 402 Query: 301 CSLALNGDCCLWR 313 + + + C +WR Sbjct: 403 ITGSKDNTCRIWR 415 Score = 153 bits (387), Expect = 7e-38, Method: Composition-based stats. Identities = 48/225 (21%), Positives = 92/225 (40%), Gaps = 20/225 (8%) Query: 88 LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVP 147 L H P+ ++ N+ G+ T S D + K+WDT +G + T+ H V ++ Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143 Query: 148 MNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK 207 +++GS+D +++ ETG C T I + F+ + + Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT--------AEIVCLSFNPQSTLVATG 195 Query: 208 SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYC 267 S+D K+WD G V T + E L + D +I+G + + Sbjct: 196 SMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR----------IITGSFDHTVVV 245 Query: 268 WNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 W++DT + +L G + S + +++ + +++ C LW Sbjct: 246 WDADTGRKVNILIG--HCAEISSASFNWDCSLILTGSMDKTCKLW 288 >1VYH-C nrPDB Length = 410 Score = 203 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 117/286 (40%), Gaps = 22/286 (7%) Query: 40 DINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLL-HTFIGHTAP 98 + R + ++ H P + + + P + +AS+D ++++ G T GHT Sbjct: 93 EWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152 Query: 99 VISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS 158 V ++F+ G LL + S D +IK+WD ++T+ H V SV + N I+ S S Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIV-SAS 211 Query: 159 YDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDC 218 D I++++ +TG+C+KT T ++W R V+ +++ + S D V++W Sbjct: 212 RDKTIKMWEVQTGYCVKTFTGHREWVRM--------VRPNQDGTLIASCSNDQTVRVWVV 263 Query: 219 IGGCVVRTFQVQPLEKGVLHHSCGMDF----------LNPEDGSTPLVISGYENGDIYCW 268 + + + + P ++SG + I W Sbjct: 264 ATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323 Query: 269 NSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWRW 314 + T L L G + + + H G + S A + +W + Sbjct: 324 DVSTGMCLMTLVG--HDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367 Score = 181 bits (460), Expect = 2e-46, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 107/285 (37%), Gaps = 42/285 (14%) Query: 10 TQNGLKATC--AKISPDGQFLA-ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD 66 T G + G+ LA + + I ++D +T+ H S + P+ Sbjct: 145 TLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTM-HGHDHNVSSVSIMPN 203 Query: 67 GQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT 125 G I +AS D ++++ + G + TF GH V + N+ G L+ + S D+++++W Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 263 Query: 126 LNGSLMKTISAHSEAVVSVDVPMNDSS-------------------ILSSGSYDGLIRIF 166 + H V + S L SGS D I+++ Sbjct: 264 ATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323 Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 D TG CL TL +W R V F +++L + D +++WD ++T Sbjct: 324 DVSTGMCLMTLVGHDNWVR--------GVLFHSGGKFILSCADDKTLRVWDYKNKRCMKT 375 Query: 227 FQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 H +DF + P V++G + + W Sbjct: 376 LNAHE------HFVTSLDFHK----TAPYVVTGSVDQTVKVWECR 410 Score = 121 bits (304), Expect = 3e-28, Method: Composition-based stats. Identities = 38/186 (20%), Positives = 78/186 (41%), Gaps = 26/186 (13%) Query: 8 VGTQNGLKATCAKISP--DGQFLA-ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWS 64 V T G + + P DG +A + + ++ + + L H + W+ Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HRHVVECISWA 285 Query: 65 PD--------------------GQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLT 103 P+ G + + S D ++++ +S G L T +GH V + Sbjct: 286 PESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVL 345 Query: 104 FNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLI 163 F+ G + + + D+++++WD N MKT++AH V S+D + +GS D + Sbjct: 346 FHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPY-VVTGSVDQTV 404 Query: 164 RIFDAE 169 ++++ Sbjct: 405 KVWECR 410 >6MZM-G nrPDB Length = 800 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 55/223 (24%), Positives = 96/223 (43%), Gaps = 20/223 (8%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRK 107 ++ H+ P +SPD + ++S+D +V + L L + GH PV F+ Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 108 GNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 167 G + D ++W T + ++ + H V N S+ +++GS D +R++D Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN-SNYVATGSADRTVRLWD 655 Query: 168 AETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 G+C++ T K PI + FS N R+L + DG V +WD G +V Sbjct: 656 VLNGNCVRIFTGHKG--------PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707 Query: 228 QVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 KG C + F DG ++ SG + + W++ Sbjct: 708 ------KGHTDTVCSLRF--SRDGE--ILASGSMDNTVRLWDA 740 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 49/204 (24%), Positives = 87/204 (42%), Gaps = 12/204 (5%) Query: 19 AKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 A SPD +L + ++ + ++ + T H P + +SP G + D Sbjct: 549 ASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK-GHNYPVWDTQFSPYGYYFVSGGHDR 607 Query: 78 SVEIIHLS-YGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA 136 + Y L F GH A V F+ N + T S D ++++WD LNG+ ++ + Sbjct: 608 VARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG 667 Query: 137 HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK 196 H + S+ N L++G+ DG + ++D G + L D + ++ Sbjct: 668 HKGPIHSLTFSPN-GRFLATGATDGRVLLWDIGHGLMVGELKGHTDT--------VCSLR 718 Query: 197 FSENARYLLVKSLDGVVKIWDCIG 220 FS + L S+D V++WD I Sbjct: 719 FSRDGEILASGSMDNTVRLWDAIK 742 Score = 173 bits (439), Expect = 8e-44, Method: Composition-based stats. Identities = 47/225 (20%), Positives = 84/225 (37%), Gaps = 25/225 (11%) Query: 90 HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN 149 GH+ PV +F+ N L +SS D ++++W + + H+ V Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 150 DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSL 209 SG +D + R++ + L+ + ++ +F N+ Y+ S Sbjct: 597 -GYYFVSGGHDRVARLWATDHYQPLRIFAGH--------LADVNCTRFHPNSNYVATGSA 647 Query: 210 DGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN 269 D V++WD + G VR F L S F + +G +G + W+ Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF----------LATGATDGRVLLWD 697 Query: 270 SDTKSLLQLLDGSLYHHSSPVMS--IHCFGNIMCSLALNGDCCLW 312 L+ G L H+ V S G I+ S +++ LW Sbjct: 698 IGHG----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738 Score = 118 bits (295), Expect = 3e-27, Method: Composition-based stats. Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 3/115 (2%) Query: 15 KATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 C + P+ ++A + + ++D+ + + T H P L +SP+G+ +AT Sbjct: 629 DVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPNGRFLATG 687 Query: 74 SDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 + D V + + +GL + GHT V SL F+R G +L + SMD ++++WD + Sbjct: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742 >6F3T-A nrPDB Length = 608 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 58/239 (24%), Positives = 105/239 (43%), Gaps = 21/239 (8%) Query: 34 LNILIYDINRRTVSQ-TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHT 91 ++L ++ +T S+ ++ H+ P +SPD + ++S+D +V + L L Sbjct: 329 DDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG 388 Query: 92 FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS 151 + GH PV F+ G + D ++W T + ++ + H V N S Sbjct: 389 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN-S 447 Query: 152 SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG 211 + +++GS D +R++D G+C++ T K PI + FS N R+L + DG Sbjct: 448 NYVATGSADRTVRLWDVLNGNCVRIFTGHKG--------PIHSLTFSPNGRFLATGATDG 499 Query: 212 VVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 V +WD G +V KG C + F DG ++ SG + + W++ Sbjct: 500 RVLLWDIGHGLMVGEL------KGHTDTVCSLRF--SRDGE--ILASGSMDNTVRLWDA 548 Score = 178 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 58/300 (19%), Positives = 105/300 (35%), Gaps = 39/300 (13%) Query: 17 TCAKISPDGQFLAIT-QGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 T ++ D +A + ++ + + + S D I SD Sbjct: 282 TAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQAS------------DLSLIDKESD 329 Query: 76 DFSVEIIHLSY-GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 134 D I+ L GH+ PV +F+ N L +SS D ++++W + + Sbjct: 330 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 389 Query: 135 SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ 194 H+ V SG +D + R++ + L+ + ++ Sbjct: 390 KGHNYPVWDTQFSPY-GYYFVSGGHDRVARLWATDHYQPLRIFAGH--------LADVNC 440 Query: 195 VKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTP 254 +F N+ Y+ S D V++WD + G VR F L S F Sbjct: 441 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF--------- 491 Query: 255 LVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMS--IHCFGNIMCSLALNGDCCLW 312 + +G +G + W+ L+ G L H+ V S G I+ S +++ LW Sbjct: 492 -LATGATDGRVLLWDIGHG----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 546 Score = 177 bits (448), Expect = 7e-45, Method: Composition-based stats. Identities = 49/204 (24%), Positives = 87/204 (42%), Gaps = 12/204 (5%) Query: 19 AKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 A SPD +L + ++ + ++ + T H P + +SP G + D Sbjct: 357 ASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK-GHNYPVWDTQFSPYGYYFVSGGHDR 415 Query: 78 SVEIIHLS-YGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA 136 + Y L F GH A V F+ N + T S D ++++WD LNG+ ++ + Sbjct: 416 VARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG 475 Query: 137 HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK 196 H + S+ N L++G+ DG + ++D G + L D + ++ Sbjct: 476 HKGPIHSLTFSPN-GRFLATGATDGRVLLWDIGHGLMVGELKGHTDT--------VCSLR 526 Query: 197 FSENARYLLVKSLDGVVKIWDCIG 220 FS + L S+D V++WD I Sbjct: 527 FSRDGEILASGSMDNTVRLWDAIK 550 Score = 52.5 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 23/149 (15%), Positives = 45/149 (30%), Gaps = 27/149 (18%) Query: 187 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL-------------- 232 N ++ V ++++ + D V++W + Q L Sbjct: 276 NAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERI 335 Query: 233 -------EKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYH 285 E +L+ G + ++S E+G + W+ T + L Sbjct: 336 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCL----VGYKG 391 Query: 286 HSSPV--MSIHCFGNIMCSLALNGDCCLW 312 H+ PV +G S + LW Sbjct: 392 HNYPVWDTQFSPYGYYFVSGGHDRVARLW 420 >6Q8F-A nrPDB Length = 514 Score = 194 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 127/308 (41%), Gaps = 26/308 (8%) Query: 18 CAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARP-------FSELCWSPDGQC 69 CA+ SPDGQ+L I +++ + + L +C+S D + Sbjct: 220 CARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEM 279 Query: 70 IATASDDFSVEIIHLSYG-LLHTFIG-HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 +AT + D +++ + G L F H+ V L+F++ + + ++S D++I+I + Sbjct: 280 LATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKS 339 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN 187 G +K HS V D + S S DG ++I++ +T C T + Sbjct: 340 GKTLKEFRGHSSFVNEATF-TQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTD 398 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLN 247 V S + +N + +V + V I + + G +VR+F E G Sbjct: 399 ITVN-SVILLPKNPEHFVVCNRSNTVVIMN-MQGQIVRSFSSGKREGGDF-------VCC 449 Query: 248 PEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI--HCFGNIMCSLAL 305 + E+ +YC+++ T L+ +L H V+ I H N++ + + Sbjct: 450 ALSPRGEWIYCVGEDFVLYCFSTVTGK----LERTLTVHEKDVIGIAHHPHQNLIATYSE 505 Query: 306 NGDCCLWR 313 +G LW+ Sbjct: 506 DGLLKLWK 513 Score = 82.1 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 22/145 (15%), Positives = 60/145 (41%), Gaps = 6/145 (4%) Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 D E L+ + +++ + +FS + +YL+ S+DG +++W+ G + + Sbjct: 196 DVEEEKFPTQLSRHIKFGQKSH---VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKD 252 Query: 227 FQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHH 286 + Q + ++ + D T ++ +G ++G I W + L+ + + + Sbjct: 253 LKYQAQDNFMMMDDAVLCMCFSRD--TEMLATGAQDGKIKVWKIQSGQCLRRFERA-HSK 309 Query: 287 SSPVMSIHCFGNIMCSLALNGDCCL 311 +S + + S + + + Sbjct: 310 GVTCLSFSKDSSQILSASFDQTIRI 334 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 32/76 (42%), Gaps = 2/76 (2%) Query: 9 GTQNGLKATCAKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG 67 G + G C +SP G+++ + + + + + +TL H + + P Sbjct: 439 GKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTV-HEKDVIGIAHHPHQ 497 Query: 68 QCIATASDDFSVEIIH 83 IAT S+D +++ Sbjct: 498 NLIATYSEDGLLKLWK 513 >6QX9-5O nrPDB Length = 357 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 56/301 (18%), Positives = 114/301 (37%), Gaps = 47/301 (15%) Query: 50 LVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL--LHTFIGHTAPVISLTFNRK 107 L++ H + P+G +A+A D + + ++ T GH+ V+ L +N Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120 Query: 108 GNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 167 G++LF++S D+++ +WD+ G +K + H+ V S ++ +GS DG ++++D Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180 Query: 168 AETGHCLKTLTYDKDWKR---------------------------------ENGVVPISQ 194 ++T ++ Sbjct: 181 IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240 Query: 195 VKFSENARYLLVKSLDGVVKIWDCI----GGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 + S YLL ++D V++WD V+ FQ C D Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS----WSPD 296 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 GS + +G + +Y W++ ++ +L L G + S ++ H I+ S + + Sbjct: 297 GSK--IAAGSADRFVYVWDTTSRRILYKLPG--HAGSINEVAFHPDEPIIISASSDKRLY 352 Query: 311 L 311 + Sbjct: 353 M 353 Score = 101 bits (252), Expect = 3e-22, Method: Composition-based stats. Identities = 25/148 (16%), Positives = 64/148 (43%), Gaps = 10/148 (6%) Query: 24 DGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIH 83 Q ++ +I ++D+ + ++ T+ HA + L S +G + + + D +V + Sbjct: 205 SDQIISGGIDNDIKVWDLRQNKLTYTM-RGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263 Query: 84 L-----SYGLLHTFIG----HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 134 + + F G ++ +++ G+ + S D + +WDT + ++ + Sbjct: 264 VRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL 323 Query: 135 SAHSEAVVSVDVPMNDSSILSSGSYDGL 162 H+ ++ V ++ I+S+ S L Sbjct: 324 PGHAGSINEVAFHPDEPIIISASSDKRL 351 >6HQA-B nrPDB Length = 722 Score = 190 bits (483), Expect = 5e-49, Method: Composition-based stats. Identities = 51/217 (23%), Positives = 93/217 (42%), Gaps = 11/217 (5%) Query: 19 AKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 SPD ++L + ++ + ++ ++ T + H+ ++ +SP G ATAS D Sbjct: 459 VDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYK-GHSSSVWDVKFSPMGHYFATASHDQ 517 Query: 78 SVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA 136 + + + L F GH V + F+ LFT S D++ ++WD G ++ Sbjct: 518 TARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMG 577 Query: 137 HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK 196 HS A+ + V D L+S D ++ ++D TG +K + G I + Sbjct: 578 HSGAINCLAVSP-DGRWLASAGEDSVVCLWDISTGRRIKAMRGH-------GRSSIYSLA 629 Query: 197 FSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 FS L+ D V++WD + Q +P+ Sbjct: 630 FSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEPIN 666 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 53/282 (18%), Positives = 110/282 (39%), Gaps = 40/282 (14%) Query: 15 KATCAKISPDGQFLAIT-QGLNILIYDINRRTVSQTL--------------------VTS 53 TC K + D +A Q I ++ I+ + L + Sbjct: 392 DLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVG 451 Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHLS-YGLLHTFIGHTAPVISLTFNRKGNLLF 112 H+ + +SPD + + + S+D +V + L Y L ++ GH++ V + F+ G+ Sbjct: 452 HSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFA 511 Query: 113 TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 T+S D++ ++W + ++ + H V V+ N + + +GS D R++D G Sbjct: 512 TASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLF-TGSSDKTARMWDIARGE 570 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 232 C++ I+ + S + R+L D VV +WD G ++ + Sbjct: 571 CVRVFMGHSG--------AINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGH-- 620 Query: 233 EKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS 274 S +G+ +++S + + W+ + Sbjct: 621 -----GRSSIYSLAFSREGT--VLVSTGADNSVRVWDVKKNT 655 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 45/278 (16%), Positives = 95/278 (34%), Gaps = 42/278 (15%) Query: 57 PFSELCWSPDGQCIATASDDFSVEIIHLSYGLLH----------------------TFIG 94 + L ++ D +A+ D +++ + L +G Sbjct: 392 DLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVG 451 Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSIL 154 H+ V + F+ L + S D+++++W + + + HS +V V Sbjct: 452 HSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM-GHYF 510 Query: 155 SSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVK 214 ++ S+D R++ + + L+ + + V+F N+ YL S D + Sbjct: 511 ATASHDQTARLWSCDHIYPLRIFAGH--------LNDVDCVEFHPNSTYLFTGSSDKTAR 562 Query: 215 IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS 274 +WD G VR F L S + S E+ + W+ T Sbjct: 563 MWDIARGECVRVFMGHSGAINCLAVSP----------DGRWLASAGEDSVVCLWDISTGR 612 Query: 275 LLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 ++ + G S ++ G ++ S + +W Sbjct: 613 RIKAMRGH-GRSSIYSLAFSREGTVLVSTGADNSVRVW 649 >6ID0-T nrPDB Length = 514 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 64/313 (20%), Positives = 119/313 (38%), Gaps = 32/313 (10%) Query: 11 QNGLKAT--CAKISPDGQ-FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG 67 +G C + P Q F+ + I I+D+ + +L T H + S Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSL-TGHISTVRGVIVSTRS 258 Query: 68 QCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL 126 + + +D V+ L Y ++ + GH + V L + ++L T S D + +IWD Sbjct: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318 Query: 127 NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 186 + + T+S H+ AV +V + I+ +GS+D IR++D G TLT K Sbjct: 319 TKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTRVTLTNHKK---- 373 Query: 187 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 246 + V S D +K W G ++ H++ Sbjct: 374 ----SVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSG--------HNAIINTLT 420 Query: 247 NPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMS------IHCFGNIM 300 DG +++SG +NG ++ W+ T Q + ++ S S + + Sbjct: 421 VNSDG---VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRL 477 Query: 301 CSLALNGDCCLWR 313 + + ++R Sbjct: 478 LTAEADKTIKVYR 490 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 42/233 (18%), Positives = 73/233 (31%), Gaps = 22/233 (9%) Query: 82 IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAV 141 H + L GH V + T S D +IKIWD +G L +++ H V Sbjct: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTV 249 Query: 142 VSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA 201 V V + S G D ++ +D E ++ + + + Sbjct: 250 RGVIVSTRSPYLFSCG-EDKQVKCWDLEYNKVIR--------HYHGHLSAVYGLDLHPTI 300 Query: 202 RYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE 261 L+ S D +IWD V T + P +I+G Sbjct: 301 DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE----------PQIITGSH 350 Query: 262 NGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWRW 314 + I W+ L + + S + +H S + + W++ Sbjct: 351 DTTIRLWDLVAGKTRVTL--TNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKF 400 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 50/136 (36%), Gaps = 13/136 (9%) Query: 10 TQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQC 69 T + + P A NI + + Q L + H + L + DG Sbjct: 369 TNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNL-SGHNAIINTLTVNSDG-V 426 Query: 70 IATASDDFSVEIIHLSYGLLHTFIGH----------TAPVISLTFNRKGNLLFTSSMDES 119 + + +D+ ++ + G + H + + + F++ + L T+ D++ Sbjct: 427 LVSGADNGTMHLWDWRTGYNFQRV-HAAVQPGSLDSESGIFACAFDQSESRLLTAEADKT 485 Query: 120 IKIWDTLNGSLMKTIS 135 IK++ + + +T Sbjct: 486 IKVYREDDTATEETHP 501 >5GAN-H nrPDB Length = 465 Score = 186 bits (471), Expect = 1e-47, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 119/309 (38%), Gaps = 30/309 (9%) Query: 14 LKATCAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPD-GQCIA 71 + +S D +A ++ + + + SH + W PD + Sbjct: 176 KPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMI 235 Query: 72 TASDDFSVEIIHLSYG-----LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL 126 + ++D ++ S LL +GH + + ++ G + ++S D + ++WD Sbjct: 236 SCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDAS 295 Query: 127 NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 186 + H + V S+ D S++ SG D L ++D +G + TL Sbjct: 296 THQELLLQEGHDKGVFSLSFQC-DGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSK---- 350 Query: 187 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF- 245 PI V +S N + DG++ +WD +R L + + H + Sbjct: 351 ----PIYTVAWSPNGYQVATGGGDGIINVWD------IRKRDEGQLNQILAHRNIVTQVR 400 Query: 246 LNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN--IMCSL 303 + EDG LV GY + I ++SDT L GSL H+ ++S+ N + S Sbjct: 401 FSKEDGGKKLVSCGY-DNLINVYSSDT----WLKMGSLAGHTDKIISLDISNNSHFLVSG 455 Query: 304 ALNGDCCLW 312 + LW Sbjct: 456 GWDRSIKLW 464 Score = 134 bits (336), Expect = 6e-32, Method: Composition-based stats. Identities = 44/204 (21%), Positives = 81/204 (39%), Gaps = 14/204 (6%) Query: 19 AKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 K P G+F+ + + + ++D + L H + L + DG + + D Sbjct: 271 VKYHPSGKFIGSASHDMTWRLWDASTHQEL-LLQEGHDKGVFSLSFQCDGSLVCSGGMDS 329 Query: 78 SVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL--MKTI 134 + + G + T GH+ P+ ++ ++ G + T D I +WD + I Sbjct: 330 LSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQI 389 Query: 135 SAHSEAVVSVDVPMNDS-SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 193 AH V V D L S YD LI ++ ++T + +L D I Sbjct: 390 LAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDK--------II 441 Query: 194 QVKFSENARYLLVKSLDGVVKIWD 217 + S N+ +L+ D +K+W+ Sbjct: 442 SLDISNNSHFLVSGGWDRSIKLWN 465 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 30/126 (23%), Positives = 57/126 (45%), Gaps = 7/126 (5%) Query: 6 TPVGTQNGL--KATCAKISPDGQFLAITQGLNIL-IYDINRRTVSQ-TLVTSHARPFSEL 61 + V T G SP+G +A G I+ ++DI +R Q + +H +++ Sbjct: 340 SKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQV 399 Query: 62 CWSPD--GQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDE 118 +S + G+ + + D + + L + + GHT +ISL + + L + D Sbjct: 400 RFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDR 459 Query: 119 SIKIWD 124 SIK+W+ Sbjct: 460 SIKLWN 465 Score = 47.8 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 26/127 (20%), Positives = 45/127 (35%), Gaps = 10/127 (7%) Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLN 247 PIS V S + + S V+ + +QPL + + H + ++ Sbjct: 174 STKPISAVSLSTDDMVVATGSW--------AGDLQVLNSQTLQPLTQKLDSHVGKIGAID 225 Query: 248 PEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPV--MSIHCFGNIMCSLAL 305 S +IS E+G I + + L G L H + + H G + S + Sbjct: 226 WHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASH 285 Query: 306 NGDCCLW 312 + LW Sbjct: 286 DMTWRLW 292 >3MKQ-A nrPDB Length = 814 Score = 184 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 116/294 (39%), Gaps = 23/294 (7%) Query: 19 AKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 P ++ T + I++ + +++ + P + I SDDF Sbjct: 19 IDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVT-ETPVRAGKFIARKNWIIVGSDDF 77 Query: 78 SVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG-SLMKTIS 135 + + + + G + F H + S+ + + + S D ++K+W+ N +L +T Sbjct: 78 RIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFE 137 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 H V+ V D S +SG D ++++ TLT +E GV + Sbjct: 138 GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTT----GQERGVNYVDYY 193 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 + Y++ S D +KIWD V T + H + F + P+ Sbjct: 194 PL-PDKPYMITASDDLTIKIWDYQTKSCVATLEG---------HMSNVSFAVFH-PTLPI 242 Query: 256 VISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFG--NIMCSLALNG 307 +ISG E+G + WNS T + + L+ L S ++ H G N + S NG Sbjct: 243 IISGSEDGTLKIWNSSTYKVEKTLNVGLER--SWCIATHPTGRKNYIASGFDNG 294 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 48/261 (18%), Positives = 101/261 (38%), Gaps = 21/261 (8%) Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFT 113 + + + P + T VEI + + + + PV + F + N + Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIV 72 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD-AETGH 172 S D I++++ G + AH + + S+ V +L SGS D +++++ Sbjct: 73 GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWENNWA 131 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSE-NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQP 231 +T + + + V F+ + LD VK+W G F + Sbjct: 132 LEQTFEGHEHF--------VMCVAFNPKDPSTFASGCLDRTVKVWSL--GQSTPNFTLTT 181 Query: 232 LEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVM 291 ++ +++ +D+ D P +I+ ++ I W+ TKS + L+G + + Sbjct: 182 GQERGVNY---VDYYPLPD--KPYMITASDDLTIKIWDYQTKSCVATLEG--HMSNVSFA 234 Query: 292 SIHCFGNIMCSLALNGDCCLW 312 H I+ S + +G +W Sbjct: 235 VFHPTLPIIISGSEDGTLKIW 255 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 33/186 (17%), Positives = 68/186 (36%), Gaps = 5/186 (2%) Query: 18 CAKISPD--GQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP--DGQCIATA 73 C +P F + + ++ + + T + TL T R + + + P D + TA Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITA 204 Query: 74 SDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK 132 SDD +++I + T GH + V F+ ++ + S D ++KIW++ + K Sbjct: 205 SDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEK 264 Query: 133 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 T++ E + + +D + +L G Sbjct: 265 TLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAA 324 Query: 193 SQVKFS 198 + F+ Sbjct: 325 ASDIFT 330 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 44/123 (35%), Gaps = 12/123 (9%) Query: 192 ISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG 251 + + F ++L G V+IW+ VR+ QV + Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKN------- 68 Query: 252 STPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCL 311 +I G ++ I +N +T +++D + +++H + S + + L Sbjct: 69 ---WIIVGSDDFRIRVFNYNTGE--KVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 312 WRW 314 W W Sbjct: 124 WNW 126 Score = 32.4 bits (72), Expect = 0.23, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 53/142 (37%), Gaps = 24/142 (16%) Query: 18 CAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 SP+G+F+ + +IY + W PD A + Sbjct: 361 SLAHSPNGRFVTVVGDGEYVIYTALAWRNKA------FGKCQDFVWGPDSNSYALIDETG 414 Query: 78 SVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSS-----MDESIKIWDTLNGSLMK 132 ++ + ++ + ++ S+ + + LF+ + D + +D NG+L++ Sbjct: 415 QIK-YYKNFKEVTSW--------SVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVR 465 Query: 133 TISAHSEAVVSVDVPMNDSSIL 154 I +++ V + ++ ++ Sbjct: 466 RIDVNAKDV----IWSDNGELV 483 Score = 31.7 bits (70), Expect = 0.42, Method: Composition-based stats. Identities = 44/265 (16%), Positives = 81/265 (30%), Gaps = 58/265 (21%) Query: 15 KATCAKISPDGQ--FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIAT 72 ++ C P G+ ++A + + + +L P +L WS G A Sbjct: 272 RSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSL-----DPVGKLVWS--GGKNAA 324 Query: 73 ASDDFSVEI---IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 ASD F+ I + + T + S+ + + + NG Sbjct: 325 ASDIFTAVIRGNEEVEQDEPLSLQ--TKELGSVDVFPQS-------------LAHSPNGR 369 Query: 130 LMKTISAHSEAVVSVDVPMNDSSI-----LSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 + T+ E V+ + + + G + D ETG + Sbjct: 370 FV-TVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALID-ETGQI--------KYY 419 Query: 185 RENGVVPISQVKFSENARYLLVKS-----LDGVVKIWDCIGGCVVRTFQVQPLEKGVLHH 239 + V V L + DG V +D G +VR V Sbjct: 420 KNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVN--------- 470 Query: 240 SCGMDFLNPEDGSTPLVISGYENGD 264 D + ++G ++++ NGD Sbjct: 471 --AKDVIWSDNGELVMIVNTNSNGD 493 >3DM0-A nrPDB Length = 694 Score = 181 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 133/334 (39%), Gaps = 48/334 (14%) Query: 6 TPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINR----RTVSQTLVTSHARPFSEL 61 T + + A I ++ ++ +I+++ + + V+Q +T H+ ++ Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESI 120 S DGQ + S D + + L+ G+ F+GHT V+S+ F+ + ++S D +I Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTI 496 Query: 121 KIWDTLNGSLMKTIS----AHSEAVVSVDVPMND-SSILSSGSYDGLIRIFDAETGHCLK 175 K+W+TL G TIS H + V V N + S S+D +++++ Sbjct: 497 KLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRS 555 Query: 176 TLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKG 235 TL + +S V S + DGVV +WD G + + + Sbjct: 556 TLAGHTGY--------VSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEAN----S 603 Query: 236 VLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSS------- 288 V+H C + + + E+G I W+ ++KS+++ L L + Sbjct: 604 VIHALCFS-------PNRYWLCAATEHG-IKIWDLESKSIVEDLKVDLKAEAEKADNSGP 655 Query: 289 ----------PVMSIHCFGNIMCSLALNGDCCLW 312 ++ G+ + S +G +W Sbjct: 656 AATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVW 689 Score = 155 bits (391), Expect = 2e-38, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 106/278 (38%), Gaps = 29/278 (10%) Query: 44 RTVSQTLVTSHARPFSELCWSPDG-QCIATASDDFSVEIIHLSYGLL------HTFIGHT 96 V + + +H + + D I +AS D S+ + L+ GH+ Sbjct: 371 GLVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHS 430 Query: 97 APVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSS 156 V + + G + S D +++WD G + H++ V+SV +++ I+ S Sbjct: 431 HFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIV-S 489 Query: 157 GSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN--ARYLLVKSLDGVVK 214 S D I++++ G C T++ E +S V+FS N ++ S D VK Sbjct: 490 ASRDRTIKLWNTL-GECKYTISE----GGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVK 544 Query: 215 IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS 274 +W+ + T H DGS L SG ++G + W+ Sbjct: 545 VWNLSNCKLRSTLAG--------HTGYVSTVAVSPDGS--LCASGGKDGVVLLWDLAEGK 594 Query: 275 LLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 L L+ + H+ + +C+ +G +W Sbjct: 595 KLYSLEANSVIHA---LCFSPNRYWLCAATEHG-IKIW 628 >2YNP-A nrPDB Length = 604 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 116/294 (39%), Gaps = 23/294 (7%) Query: 19 AKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 P ++ T + +++ + +++ + P + I SDDF Sbjct: 19 IDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVT-ETPVRAGKFIARKNWIIVGSDDF 77 Query: 78 SVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG-SLMKTIS 135 + + + + G + F H + S+ + + + S D ++K+W+ N +L +T Sbjct: 78 RIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFE 137 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 H V+ V D S +SG D ++++ TLT +E GV + Sbjct: 138 GHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTT----GQERGVNYVDYY 193 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 + Y++ S D +KIWD V T + H + F + P+ Sbjct: 194 PL-PDKPYMITASDDLTIKIWDYQTKSCVATLEG---------HMSNVSFAVFH-PTLPI 242 Query: 256 VISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFG--NIMCSLALNG 307 +ISG E+G + WNS T + + L+ L S ++ H G N + S NG Sbjct: 243 IISGSEDGTLKIWNSSTYKVEKTLNVGLER--SWCIATHPTGRKNYIASGFDNG 294 Score = 127 bits (319), Expect = 6e-30, Method: Composition-based stats. Identities = 48/261 (18%), Positives = 102/261 (39%), Gaps = 21/261 (8%) Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFT 113 + + + P + T VE+ + + + + PV + F + N + Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIV 72 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET-GH 172 S D I++++ G + AH + + S+ V +L SGS D +++++ E Sbjct: 73 GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTVKLWNWENNWA 131 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSE-NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQP 231 +T + + + V F+ + LD VK+W G F + Sbjct: 132 LEQTFEGHEHF--------VMCVAFNPKDPSTFASGCLDRTVKVWSL--GQSTPNFTLTT 181 Query: 232 LEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVM 291 ++ +++ +D+ D P +I+ ++ I W+ TKS + L+G + + Sbjct: 182 GQERGVNY---VDYYPLPD--KPYMITASDDLTIKIWDYQTKSCVATLEG--HMSNVSFA 234 Query: 292 SIHCFGNIMCSLALNGDCCLW 312 H I+ S + +G +W Sbjct: 235 VFHPTLPIIISGSEDGTLKIW 255 Score = 97.9 bits (242), Expect = 5e-21, Method: Composition-based stats. Identities = 33/186 (17%), Positives = 68/186 (36%), Gaps = 5/186 (2%) Query: 18 CAKISPD--GQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP--DGQCIATA 73 C +P F + + ++ + + T + TL T R + + + P D + TA Sbjct: 145 CVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITA 204 Query: 74 SDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK 132 SDD +++I + T GH + V F+ ++ + S D ++KIW++ + K Sbjct: 205 SDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEK 264 Query: 133 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 T++ E + + +D + +L G Sbjct: 265 TLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAA 324 Query: 193 SQVKFS 198 + F+ Sbjct: 325 ASDIFT 330 Score = 54.8 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 20/123 (16%), Positives = 44/123 (35%), Gaps = 12/123 (9%) Query: 192 ISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG 251 + + F ++L G V++W+ VR+ QV + Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKN------- 68 Query: 252 STPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCL 311 +I G ++ I +N +T +++D + +++H + S + + L Sbjct: 69 ---WIIVGSDDFRIRVFNYNTGE--KVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 312 WRW 314 W W Sbjct: 124 WNW 126 Score = 31.3 bits (69), Expect = 0.58, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 53/142 (37%), Gaps = 24/142 (16%) Query: 18 CAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 SP+G+F+ + +IY + W PD A + Sbjct: 361 SLAHSPNGRFVTVVGDGEYVIYTALAWRNKA------FGKCQDFVWGPDSNSYALIDETG 414 Query: 78 SVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSS-----MDESIKIWDTLNGSLMK 132 ++ + ++ + ++ S+ + + LF+ + D + +D NG+L++ Sbjct: 415 QIK-YYKNFKEVTSW--------SVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVR 465 Query: 133 TISAHSEAVVSVDVPMNDSSIL 154 I +++ V + ++ ++ Sbjct: 466 RIDVNAKDV----IWSDNGELV 483 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 27/69 (39%), Gaps = 9/69 (13%) Query: 15 KATCAKISPDGQ--FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIAT 72 ++ C P G+ ++A + + + +L P +L WS G A Sbjct: 272 RSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSL-----DPVGKLVWS--GGKNAA 324 Query: 73 ASDDFSVEI 81 ASD F+ I Sbjct: 325 ASDIFTAVI 333 >5NZU-C nrPDB Length = 905 Score = 174 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 51/276 (18%), Positives = 105/276 (38%), Gaps = 24/276 (8%) Query: 10 TQNGLKATCAKISPDGQF-LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQ 68 T + + P + LA ++ +++ +T+ +T P + Sbjct: 12 TARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDL-PVRAAKFVARKN 70 Query: 69 CIATASDDFSVEIIHLSY-GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 + T +DD + + + + +H F H+ + + + + TSS D IK+WD Sbjct: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130 Query: 128 G-SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 186 S + H+ V+ + + D++ +S S D I+++ + TL + Sbjct: 131 KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEK---- 186 Query: 187 NGVVPISQVKFSENA--RYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD 244 ++ + + YL+ + D +VKIWD V+T + Sbjct: 187 ----GVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP--- 239 Query: 245 FLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLD 280 P++I+G E+G + W+S T L L+ Sbjct: 240 -------ELPIIITGSEDGTVRIWHSSTYRLESTLN 268 Score = 163 bits (413), Expect = 7e-41, Method: Composition-based stats. Identities = 50/271 (18%), Positives = 103/271 (38%), Gaps = 20/271 (7%) Query: 44 RTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISL 102 R + +T+ + + P + + + SV + + L TF PV + Sbjct: 4 RLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAA 63 Query: 103 TFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGL 162 F + N + T + D I++++ + AHS+ + + V IL+S S D L Sbjct: 64 KFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTS-SDDML 122 Query: 163 IRIFDA-ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 I+++D + C + + + + P ++ SLD +K+W Sbjct: 123 IKLWDWDKKWSCSQVFEGHTHYVMQIVINP-------KDNNQFASASLDRTIKVWQLGSS 175 Query: 222 CVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDG 281 T + + + G P +ISG ++ + W+ K+ +Q L+G Sbjct: 176 SPNFTLEGHEKGVNCIDY--------YSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEG 227 Query: 282 SLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + + S H I+ + + +G +W Sbjct: 228 --HAQNVSCASFHPELPIIITGSEDGTVRIW 256 Score = 162 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 52/261 (19%), Positives = 97/261 (37%), Gaps = 23/261 (8%) Query: 21 ISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVE 80 ++ + + I +++ N + +H+ + P I T+SDD ++ Sbjct: 66 VARKNWVVTGADDMQIRVFNYNTLERVH-MFEAHSDYIRCIAVHPTQPFILTSSDDMLIK 124 Query: 81 IIH--LSYGLLHTFIGHTAPVISLTFNR-KGNLLFTSSMDESIKIWDTLNGSLMKTISAH 137 + + F GHT V+ + N N ++S+D +IK+W + S T+ H Sbjct: 125 LWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGH 184 Query: 138 SEAVVSVDV-PMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK 196 + V +D D L SG+ D L++I+D + C++TL +S Sbjct: 185 EKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHA--------QNVSCAS 236 Query: 197 FSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLV 256 F ++ S DG V+IW + T + G + + ++ Sbjct: 237 FHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSII 296 Query: 257 I---------SGYENGDIYCW 268 + S NG I W Sbjct: 297 VKLGREEPAMSMDANGKI-IW 316 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 43/202 (21%), Positives = 85/202 (42%), Gaps = 14/202 (6%) Query: 17 TCAKISPDGQF-LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP-DGQCIATAS 74 C + P F L + + I ++D +++ + H ++ +P D A+AS Sbjct: 103 RCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASAS 162 Query: 75 DDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGN--LLFTSSMDESIKIWDTLNGSLM 131 D ++++ L + T GH V + + G+ L + + D +KIWD N + + Sbjct: 163 LDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCV 222 Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 191 +T+ H++ V I+ +GS DG +RI+ + T TL Y G+ Sbjct: 223 QTLEGHAQNVSCASFHPELP-IIITGSEDGTVRIWHSSTYRLESTLNY--------GMER 273 Query: 192 ISQVKFSENARYLLVKSLDGVV 213 + V + + + +G + Sbjct: 274 VWCVASLRGSNNVALGYDEGSI 295 Score = 75.6 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 35/184 (19%), Positives = 78/184 (42%), Gaps = 23/184 (12%) Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 191 + ++A S+ V SVD+ + +L+S Y+G + +++ ET +KT E +P Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASL-YNGSVCVWNHETQTLVKTF--------EVCDLP 59 Query: 192 ISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG 251 + KF +++ + D +++++ V F+ + Sbjct: 60 VRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHP---------- 109 Query: 252 STPLVISGYENGDIYCWNSDTK-SLLQLLDGSLYHHSSPVMSIHC-FGNIMCSLALNGDC 309 + P +++ ++ I W+ D K S Q+ +G + H + I+ N S +L+ Sbjct: 110 TQPFILTSSDDMLIKLWDWDKKWSCSQVFEG--HTHYVMQIVINPKDNNQFASASLDRTI 167 Query: 310 CLWR 313 +W+ Sbjct: 168 KVWQ 171 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 22/138 (15%), Positives = 49/138 (35%), Gaps = 12/138 (8%) Query: 177 LTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGV 236 L D K + V ++L +G V +W+ +V+TF+V L Sbjct: 3 LRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRA 62 Query: 237 LHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF 296 + V++G ++ I +N +T + + + + +++H Sbjct: 63 AKFVARKN----------WVVTGADDMQIRVFNYNTLERVHMFEA--HSDYIRCIAVHPT 110 Query: 297 GNIMCSLALNGDCCLWRW 314 + + + + LW W Sbjct: 111 QPFILTSSDDMLIKLWDW 128 >5FL8-q nrPDB Length = 515 Score = 173 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 67/360 (18%), Positives = 134/360 (37%), Gaps = 76/360 (21%) Query: 6 TPVGTQNGLKAT--CAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELC 62 TP+ T G C SPDG+ +A + I ++D + H++ + L Sbjct: 177 TPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLS 236 Query: 63 WSP-------DGQCIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLLFTS 114 W P +A++S D +++I + +T GHT V + + +G LL++ Sbjct: 237 WEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG-LLYSG 295 Query: 115 SMDESIKIWDTLN-GSLMKTISAHSEAVVSVDVPM------------------------- 148 S D ++++WD + G + + +H+ V + + Sbjct: 296 SHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKK 355 Query: 149 -------------NDSSILSSGSYDGLIRIFD-AETGHCLKTLTYDKDWKRENGVVPISQ 194 N ++ + S D + +++ ++ + +T + ++ Sbjct: 356 ALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKL--------VNH 407 Query: 195 VKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTP 254 V FS + RY++ S D +K+WD G + TF+ H + D Sbjct: 408 VAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRG--------HVASVYQVAWSSD--CR 457 Query: 255 LVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI--HCFGNIMCSLALNGDCCLW 312 L++S ++ + W+ T + L L H V ++ G +CS + LW Sbjct: 458 LLVSCSKDTTLKVWDVRT----RKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 152 bits (383), Expect = 2e-37, Method: Composition-based stats. Identities = 55/316 (17%), Positives = 112/316 (35%), Gaps = 53/316 (16%) Query: 38 IYDINRRTVSQTLVTSHARPFSELCWSPDGQC-IATASDDFSVEIIHLSYGLL-HTFIGH 95 ++ + T S + + H ++P + T + D + I HT GH Sbjct: 126 VFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGH 185 Query: 96 TAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT-ISAHSEAVVSVDVP------M 148 V+ ++++ G ++ T SMD +I++WD +G + + HS+ + S+ Sbjct: 186 YNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKP 245 Query: 149 NDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKS 208 L+S S DG I+I+D + C T++ + +S VK+ L S Sbjct: 246 GSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTN--------SVSCVKWGGQG-LLYSGS 296 Query: 209 LDGVVKIWDCI-GGCVVRTFQVQ-----------------------------PLEKGVLH 238 D V++WD G + + P E Sbjct: 297 HDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKA 356 Query: 239 HSCGMDFLNPEDGSTPLVISGYENGDIYCWN--SDTKSLLQLLDGSLYHHSSPVMSIHCF 296 S ++++ ++ ++ WN TK + ++ + + ++ Sbjct: 357 LENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARM---TGHQKLVNHVAFSPD 413 Query: 297 GNIMCSLALNGDCCLW 312 G + S + + LW Sbjct: 414 GRYIVSASFDNSIKLW 429 Score = 89.0 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 22/126 (17%), Positives = 53/126 (42%), Gaps = 5/126 (3%) Query: 2 FQFVTPVGTQNGLKATC--AKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPF 58 + P+ G + SPDG+++ + + +I ++D T H Sbjct: 389 LKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTF-RGHVASV 447 Query: 59 SELCWSPDGQCIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLLFTSSMD 117 ++ WS D + + + S D ++++ + L GH V ++ ++ G + + D Sbjct: 448 YQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKD 507 Query: 118 ESIKIW 123 + +++W Sbjct: 508 KMVRLW 513 Score = 65.2 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 31/188 (16%), Positives = 68/188 (36%), Gaps = 26/188 (13%) Query: 138 SEAVVSVDVPMN-DSSILSSG---SYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 193 S+ V ++D+ N SS++ G + D + ++ +K +T +G + Sbjct: 89 SDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILC 148 Query: 194 QVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGST 253 + ++ + D +IWDC + T + H++ + DG Sbjct: 149 SAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKG--------HYNWVLCVSWSPDGE- 199 Query: 254 PLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF---------GNIMCSLA 304 ++ +G + I W+ + L +L HS + S+ + S + Sbjct: 200 -VIATGSMDNTIRLWDPKSGQC---LGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSS 255 Query: 305 LNGDCCLW 312 +G +W Sbjct: 256 KDGTIKIW 263 >6N9G-C nrPDB Length = 353 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 118/309 (38%), Gaps = 28/309 (9%) Query: 13 GLKATCAKISPDGQ-FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIA 71 G K C D + ++ +Q ++++D T + VT ++P G IA Sbjct: 63 GNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-TNKEHAVTMPCTWVMACAYAPSGCAIA 121 Query: 72 TASDDFSVEIIHLSYGL-------LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 D + L++ + HT + + +F + T+S D + +WD Sbjct: 122 CGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWD 181 Query: 125 TLNGSLMKTISAHSEAVVSVD-VPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDW 183 +G L+++ H V+ +D P + SG D ++D +G C++ + Sbjct: 182 VESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESD 241 Query: 184 KRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGM 243 ++ V++ + S D +++D V + ++ ++ + + Sbjct: 242 --------VNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS----KESIIFGASSV 289 Query: 244 DFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSL 303 DF S L+ +GY + I W+ S + +L G + + + + G CS Sbjct: 290 DF----SLSGRLLFAGYNDYTINVWDVLKGSRVSILFG--HENRVSTLRVSPDGTAFCSG 343 Query: 304 ALNGDCCLW 312 + + +W Sbjct: 344 SWDHTLRVW 352 Score = 124 bits (311), Expect = 5e-29, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 77/221 (34%), Gaps = 15/221 (6%) Query: 1 MFQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSE 60 M V + C+ + D Q L + ++D+ + Q+ H Sbjct: 142 MAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF-HGHGADVLC 200 Query: 61 LCWSP--DGQCIATASDDFSVEIIHLSYGLLHT-FIGHTAPVISLTFNRKGNLLFTSSMD 117 L +P G + D + + G F H + V S+ + G+ + S D Sbjct: 201 LDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDD 260 Query: 118 ESIKIWDTLNGSLMKTISAHSE--AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLK 175 + +++D + S S SVD + +L +G D I ++D G + Sbjct: 261 ATCRLYDLRADREVAIYSKESIIFGASSVDFSL-SGRLLFAGYNDYTINVWDVLKGSRVS 319 Query: 176 TLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW 216 L ++ +S ++ S + S D +++W Sbjct: 320 ILFGHENR--------VSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 15/140 (10%), Positives = 41/140 (29%), Gaps = 14/140 (10%) Query: 177 LTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGV 236 + + + + ++ R ++ S DG V +WD ++ Sbjct: 51 FVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT----------TNKEHA 100 Query: 237 LHHSCGMDFLNPEDGSTPLVISGYENGDIYCW----NSDTKSLLQLLDGSLYHHSSPVMS 292 + C S + G + + + + + +++ + S Sbjct: 101 VTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACS 160 Query: 293 IHCFGNIMCSLALNGDCCLW 312 + + + +G C LW Sbjct: 161 FTNSDMQILTASGDGTCALW 180 >6QX9-4B nrPDB Length = 522 Score = 168 bits (425), Expect = 3e-42, Method: Composition-based stats. Identities = 65/320 (20%), Positives = 112/320 (35%), Gaps = 35/320 (10%) Query: 4 FVTPVGTQNGLKATCAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELC 62 F + +G + SP+ + LA ++ + + TL H + Sbjct: 224 FCSQIGDDRPISY--CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTL-RGHNTNVGAIV 280 Query: 63 WSPDGQC--------IATASDDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFT 113 + P +A+ + D SV++ L GHT V + ++ G L T Sbjct: 281 FHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGT 340 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 173 + D S ++WD + HS V + D S+ +G D R++D TG C Sbjct: 341 TCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQ-DGSLAGTGGLDAFGRVWDLRTGRC 399 Query: 174 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF-QVQPL 232 + L + I + FS N ++ S D K+WD V T Q L Sbjct: 400 IMFLEGH--------LKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNL 451 Query: 233 EKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMS 292 GV +F +++G + W S L+ L G + + Sbjct: 452 VTGVKFEPIHGNF----------LLTGAYDNTAKIWTHPGWSPLKTLAG--HEGKVMGLD 499 Query: 293 IHCFGNIMCSLALNGDCCLW 312 I G ++ + + + LW Sbjct: 500 ISSDGQLIATCSYDRTFKLW 519 >6G51-g nrPDB Length = 317 Score = 166 bits (421), Expect = 8e-42, Method: Composition-based stats. Identities = 66/332 (19%), Positives = 126/332 (37%), Gaps = 40/332 (12%) Query: 1 MFQFVTPVGTQNGLKATCAKISPDGQF----LAITQGLNILIYDINR----RTVSQTLVT 52 M + +T GT G +I+ QF L+ ++ I+++ + R + Q + Sbjct: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 Query: 53 SHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLL 111 H+ S++ S DGQ + S D ++ + L+ G F+GHT V+S+ F+ + Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120 Query: 112 FTSSMDESIKIWDTLNGSLMKTI--SAHSEAVVSVDVPMNDSS-ILSSGSYDGLIRIFDA 168 + S D++IK+W+TL G T+ +HSE V V N S+ I+ S +D L+++++ Sbjct: 121 VSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 ++ V S + DG +WD G + T Sbjct: 180 ANCKL--------KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231 Query: 229 VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSS 288 + + S I W+ + K ++ L + SS Sbjct: 232 GGDIINALCFSPNRYWLCAATGPS------------IKIWDLEGKIIVDELKQEVISTSS 279 Query: 289 -------PVMSIHCFGNIMCSLALNGDCCLWR 313 ++ G + + + +W+ Sbjct: 280 KAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 >4V7E-Bg nrPDB Length = 380 Score = 166 bits (421), Expect = 9e-42, Method: Composition-based stats. Identities = 60/323 (18%), Positives = 125/323 (38%), Gaps = 32/323 (9%) Query: 10 TQNGLKATC--AKISPD-GQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD 66 T G +P+ ++ +Q +++++ + + H E ++P+ Sbjct: 61 TLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKL-HCPWVMECAFAPN 119 Query: 67 GQCIATASDDFSVEIIHLSYG--------LLHTFIGHTAPVISLTFNRK-GNLLFTSSMD 117 GQ +A D + I +LS + GH S + L T S D Sbjct: 120 GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGD 179 Query: 118 ESIKIWDTLNGSLMKTI-----SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE-TG 171 ++ +WD G + S H+ V+S+ + ++++ SGS D +R++D T Sbjct: 180 QTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITS 239 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQP 231 ++T + I+ VKF + + S DG +++D G ++ + +P Sbjct: 240 RAVRTYHGHEGD--------INSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREP 291 Query: 232 LEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPV- 290 + S L+ +GY NGD Y W++ ++ L H + Sbjct: 292 DRNDNELPIVTSVAFSI---SGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRIS 348 Query: 291 -MSIHCFGNIMCSLALNGDCCLW 312 + + G+ +C+ + + + +W Sbjct: 349 CLGLSSDGSALCTGSWDKNLKIW 371 Score = 120 bits (301), Expect = 8e-28, Method: Composition-based stats. Identities = 40/227 (17%), Positives = 78/227 (34%), Gaps = 10/227 (4%) Query: 88 LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVP 147 T GH+ V SL + + N + ++S D + +W+ L I H V+ Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFA 117 Query: 148 MNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA-RYLLV 206 N S ++ G D IF+ + + S ++ + L+ Sbjct: 118 PNGQS-VACGGLDSACSIFNLSS-QADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLIT 175 Query: 207 KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIY 266 S D +WD G + F + H+ + L+ + + ISG + + Sbjct: 176 GSGDQTCVLWDVTTGQRISIF----GSEFPSGHTADVLSLSINSLNANMFISGSCDTTVR 231 Query: 267 CWNSD-TKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 W+ T ++ G + + G + + +G C L+ Sbjct: 232 LWDLRITSRAVRTYHG--HEGDINSVKFFPDGQRFGTGSDDGTCRLF 276 Score = 44.7 bits (104), Expect = 4e-05, Method: Composition-based stats. Identities = 23/94 (24%), Positives = 32/94 (34%), Gaps = 12/94 (12%) Query: 10 TQNGLKATCAKISPDGQFL-AITQGLNILIYDINRRTVS---QTLVTSHARPFSELCWSP 65 T S G+ L A + ++D + TL SH S L S Sbjct: 295 DNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSS 354 Query: 66 DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPV 99 DG + T S D +++I F GH V Sbjct: 355 DGSALCTGSWDKNLKIW--------AFSGHRKIV 380 >5OPT-p nrPDB Length = 318 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 62/290 (21%), Positives = 119/290 (41%), Gaps = 43/290 (14%) Query: 19 AKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFS 78 S D +A ++ + + L H+ S++ S +G +AS D S Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRL-EGHSAFVSDVALSNNGDFAVSASWDHS 90 Query: 79 VEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI--S 135 + + +L G+ H F+GHT V+S+TF+ + + D ++++W+ G + T+ Sbjct: 91 LRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNV-KGECLHTLGRG 149 Query: 136 AHSEAVVSVDVPMN-DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV---- 190 AH++ V V + ++ ++ SG +D L++++D +G L L ++ V Sbjct: 150 AHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGS 209 Query: 191 -----------------------------PISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 PI+Q+ FS N RY + + + ++I+D Sbjct: 210 LCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPN-RYWMCAATEKGIRIFDLENK 268 Query: 222 CVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 V+ + +K C M DG+T + SGY + I W+ Sbjct: 269 DVIVELAPEAQQKSKKTPEC-MSIAWSADGNT--LYSGYTDNVIRVWSVS 315 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 95/254 (37%), Gaps = 25/254 (9%) Query: 57 PFSELCWSPDGQCIATAS-DDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSS 115 + S D IA S D + E + GH+A V + + G+ ++S Sbjct: 28 YIKAVSTSRDNTLIAWGSNMDRNSEECEYGFP-ERRLEGHSAFVSDVALSNNGDFAVSAS 86 Query: 116 MDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLK 175 D S+++W+ G H++ V+SV ++ I+ SG D +R+++ + G CL Sbjct: 87 WDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIV-SGGRDNALRVWNVK-GECLH 144 Query: 176 TLTYDKDWKRENGVVPISQVKFSE--NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 TL R +S V+FS ++ D +VK+WD G ++ + Sbjct: 145 TL------GRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKG---- 194 Query: 234 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 293 H + DGS L S ++G W+ L + + + Sbjct: 195 ----HTNYITSVTVSPDGS--LCASSDKDGVARLWDLTKGEALSEMAAGAPINQ---ICF 245 Query: 294 HCFGNIMCSLALNG 307 MC+ G Sbjct: 246 SPNRYWMCAATEKG 259 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 30/163 (18%), Positives = 68/163 (41%), Gaps = 13/163 (7%) Query: 17 TCAKISPD---GQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 +C + SP ++ + ++DI + T + H + + SPDG A++ Sbjct: 156 SCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLL-TDLKGHTNYITSVTVSPDGSLCASS 214 Query: 74 SDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 133 D + L+ G + + AP+ + F+ + ++ + I+I+D N ++ Sbjct: 215 DKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATE-KGIRIFDLENKDVIVE 273 Query: 134 ISAHSE-------AVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 ++ ++ +S+ D + L SG D +IR++ Sbjct: 274 LAPEAQQKSKKTPECMSIAWSA-DGNTLYSGYTDNVIRVWSVS 315 >5WLC-LO nrPDB Length = 923 Score = 160 bits (405), Expect = 6e-40, Method: Composition-based stats. Identities = 60/270 (22%), Positives = 118/270 (43%), Gaps = 23/270 (8%) Query: 15 KATCAKISPDGQFLAITQGL--NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIAT 72 ++ G++LA +L+Y+ + H + L +SPDG + T Sbjct: 304 PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYI-LKQQGHFDSTNSLAYSPDGSRVVT 362 Query: 73 ASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 131 AS+D +++ ++ G L TF HT+ V ++ F ++G ++F+SS+D +++ WD + Sbjct: 363 ASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNF 422 Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGL-IRIFDAETGHCLKTLTYDKDWKRENGVV 190 +T + + ++ +GS D I ++ +TG L L+ + Sbjct: 423 RTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEG-------- 474 Query: 191 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 P+S + FS+ L S D ++IW G R+ QV+P+E + L+ Sbjct: 475 PVSCLSFSQENSVLASASWDKTIRIWSIFG----RSQQVEPIE-----VYSDVLALSMRP 525 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLD 280 + +S + G I +N + + +D Sbjct: 526 DGKEVAVSTLK-GQISIFNIEDAKQVGNID 554 Score = 140 bits (352), Expect = 9e-34, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 108/272 (39%), Gaps = 23/272 (8%) Query: 44 RTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGH-TAPVISL 102 R + ++ + + P + +A + L L + PV ++ Sbjct: 249 RITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTV 308 Query: 103 TFNRKGNLL-FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDG 161 + N+ G L F SS + +++ + S + H ++ S+ D S + + S DG Sbjct: 309 SVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSP-DGSRVVTASEDG 367 Query: 162 LIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 I+++D +G CL T ++ V+F++ + + SLDG V+ WD I Sbjct: 368 KIKVWDITSGFCLATFEEHT--------SSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRY 419 Query: 222 CVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY-ENGDIYCWNSDTKSLLQLLD 280 RTF + +C D S +V +G +N DI+ W+ T LL L Sbjct: 420 RNFRTFTGTER----IQFNCL-----AVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALS 470 Query: 281 GSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 G + +S +++ S + + +W Sbjct: 471 G--HEGPVSCLSFSQENSVLASASWDKTIRIW 500 Score = 105 bits (262), Expect = 2e-23, Method: Composition-based stats. Identities = 59/362 (16%), Positives = 110/362 (30%), Gaps = 76/362 (20%) Query: 19 AKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 ++ G L +I + ++ + R V S + +SPDG+ A AS F Sbjct: 61 IDLNKQGTLLISIDEDGRAILVNFKARNVLHHFN--FKEKCSAVKFSPDGRLFALASGRF 118 Query: 78 SVEIIHLSY-GLLHTFI---------GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 ++I F GH + SLT+++ + T+S D S KIW + Sbjct: 119 -LQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDS 177 Query: 128 GS---LMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG------------- 171 T + H + V+ + + + S DG + +++ Sbjct: 178 EEKNLAATTFNGHRDYVMGAFFSHDQEK-IYTVSKDGAVFVWEFTKRPSDDDDNESEDDD 236 Query: 172 HCLKTLTYDKDWKRE------NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR 225 + W+ + V F R L V G +++D +++ Sbjct: 237 KQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQ 296 Query: 226 TFQVQPLEKGVL-----------------------------------HHSCGMDFLNPED 250 + + H D Sbjct: 297 QLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPD 356 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 GS V++ E+G I W+ + L + + S + G +M S +L+G Sbjct: 357 GSR--VVTASEDGKIKVWDITSGFCLATFEE--HTSSVTAVQFAKRGQVMFSSSLDGTVR 412 Query: 311 LW 312 W Sbjct: 413 AW 414 Score = 88.3 bits (217), Expect = 3e-18, Method: Composition-based stats. Identities = 50/340 (14%), Positives = 116/340 (34%), Gaps = 39/340 (11%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 F+F +GT S DG+ L G + ++D+ S T H + + + Sbjct: 5 FKFSNLLGTVYRQGN--ITFSDDGKQLLSPVGNRVSVFDLINNK-SFTFEYEHRKNIAAI 61 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 121 + G + + +D +++ + ++ F+ G L +S ++ Sbjct: 62 DLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQ 120 Query: 122 IWDTLN---------GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 IW T + + + H + + S+ + IL++ S D +I+ ++ Sbjct: 121 IWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTT-SKDLSAKIWSVDSEE 179 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCV--------- 223 T + FS + + S DG V +W+ Sbjct: 180 KNLAATT-----FNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESED 234 Query: 224 --------VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSL 275 + + + +K + + +T L+ G+ +G+ ++ +L Sbjct: 235 DDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTL 294 Query: 276 LQLLDGSLYHHSSPVMSIHCFGNIMCSLALN-GDCCLWRW 314 +Q L S+ + +S++ G + + G ++ W Sbjct: 295 IQQL--SMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEW 332 >4V6W-Ag nrPDB Length = 318 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 55/333 (16%), Positives = 116/333 (34%), Gaps = 41/333 (12%) Query: 1 MFQFVTPVGTQNGLKATCAKISPD----GQFLAITQGLNILIYDINR-----RTVSQTLV 51 M + + GT G +I+ + ++ ++ ++++ + R Q + Sbjct: 1 MSETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRL 60 Query: 52 TSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNL 110 H+ S++ S DG + S D ++ + L+ G F GHT V+S+ F+ Sbjct: 61 YGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQ 120 Query: 111 LFTSSMDESIKIWDTLNGSLMKTIS--AHSEAVVSVDVPMNDSS-ILSSGSYDGLIRIFD 167 + + S D++IK+W+TL TI H++ V V N S+ I+ S +D +++++ Sbjct: 121 IVSGSRDKTIKLWNTL-AECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWN 179 Query: 168 AETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 ++ V S + D +WD G + T Sbjct: 180 LANCKL--------KNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTL 231 Query: 228 QVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLL-----DGS 282 + + + S I W+ K ++ L + Sbjct: 232 EHNDIINALCFSPNRYWLCVAYGPS------------IKIWDLACKKTVEELRPEVVSPT 279 Query: 283 LYHHSSPVMSI--HCFGNIMCSLALNGDCCLWR 313 +S+ G + + + +W+ Sbjct: 280 SKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQ 312 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 27/121 (22%), Positives = 45/121 (37%), Gaps = 18/121 (14%) Query: 18 CAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 +SPDG L++D+N TL H + LC+SP+ + + Sbjct: 198 TVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE--HNDIINALCFSPNRYWL-CVAYG 254 Query: 77 FSVEIIHLSYGLLHTFIGHTAPV------------ISLTFNRKGNLLFTSSMDESIKIWD 124 S++I L+ T V +SL ++ G LF D +I++W Sbjct: 255 PSIKIWDLA--CKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQ 312 Query: 125 T 125 Sbjct: 313 V 313 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 31/73 (42%), Gaps = 8/73 (10%) Query: 21 ISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFS--------ELCWSPDGQCIAT 72 SP+ +L + G +I I+D+ + + L P S L WS DGQ + Sbjct: 242 FSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFA 301 Query: 73 ASDDFSVEIIHLS 85 D ++ + +S Sbjct: 302 GYSDNTIRVWQVS 314 >4V8M-A7 nrPDB Length = 318 Score = 158 bits (400), Expect = 2e-39, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 119/300 (39%), Gaps = 44/300 (14%) Query: 10 TQNGLKAT-CAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQ 68 Q AT S D L+ + + + + L H+ S++ S +G Sbjct: 22 PQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRL-EGHSAFVSDVALSNNGN 80 Query: 69 CIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 +AS D S+ + +L G + F+GHT V+S+ F+ + + D ++++W+ Sbjct: 81 FAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNV-K 139 Query: 128 GSLMKTIS--AHSEAVVSVDVPMN-DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 G M T+S AH++ V V + D+ ++ SG +D L++++D TG + L ++ Sbjct: 140 GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYV 199 Query: 185 RENGVV---------------------------------PISQVKFSENARYLLVKSLDG 211 V PI+Q+ FS N RY + + + Sbjct: 200 TSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPN-RYWMCAATEK 258 Query: 212 VVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 ++I+D ++ + + C + DGST + SGY + I W Sbjct: 259 GIRIFDLENKDIIVELAPEHQGSKKIVPEC-VSIAWSADGST--LYSGYTDNVIRVWGVS 315 Score = 147 bits (370), Expect = 7e-36, Method: Composition-based stats. Identities = 64/264 (24%), Positives = 107/264 (40%), Gaps = 34/264 (12%) Query: 47 SQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTFN 105 + T V S +R + L W P+ D S E SYGL GH+A V + + Sbjct: 27 TATKVVSTSRDKTLLSWGPN-------PDRHSSEC---SYGLPDRRLEGHSAFVSDVALS 76 Query: 106 RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRI 165 GN ++S D S+++W+ NG H++ V+SV ++ I+ SG D +R+ Sbjct: 77 NNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIV-SGGRDNALRV 135 Query: 166 FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE--NARYLLVKSLDGVVKIWDCIGGCV 223 ++ + G C+ TL+ R +S V+FS +A ++ D +VK+WD G + Sbjct: 136 WNVK-GECMHTLS------RGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRL 188 Query: 224 VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSL 283 V + H + DGS L S ++G W+ L + Sbjct: 189 VTDLKG--------HTNYVTSVTVSPDGS--LCASSDKDGVARLWDLTKGEALSEMAAGA 238 Query: 284 YHHSSPVMSIHCFGNIMCSLALNG 307 + + MC+ G Sbjct: 239 PINQ---ICFSPNRYWMCAATEKG 259 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 43/236 (18%), Positives = 88/236 (37%), Gaps = 34/236 (14%) Query: 91 TFIGHTAPVISLTFNR---KGNLLFTSSMDESIKIW----DTLNGSLM-----KTISAHS 138 GH V SL + + ++S D+++ W D + + + HS Sbjct: 8 QLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 139 EAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFS 198 V V + N+ + S S+D +R+++ + G C + V FS Sbjct: 68 AFVSDVALS-NNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKD--------VLSVAFS 118 Query: 199 ENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKG--VLHHSCGMDFLNPEDGSTPLV 256 + R ++ D +++W+ G + T + S +D P++ Sbjct: 119 PDNRQIVSGGRDNALRVWNV-KGECMHTLSRGAHTDWVSCVRFSPSLDA--------PVI 169 Query: 257 ISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 +SG + + W+ T L+ L G + + +++ G++ S +G LW Sbjct: 170 VSGGWDNLVKVWDLATGRLVTDLKG--HTNYVTSVTVSPDGSLCASSDKDGVARLW 223 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 22/133 (16%), Positives = 51/133 (38%), Gaps = 14/133 (10%) Query: 8 VGTQNGLK--ATCAKISPDGQFLAITQGLNI-LIYDINRRTVSQTLVTSHARPFSELCWS 64 V G T +SPDG A + + ++D+ + + P +++C+S Sbjct: 189 VTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAG--APINQICFS 246 Query: 65 PDGQCIATASDDFSVEIIHLSYGLLHTFIGHTA--------PVISLTFNRKGNLLFTSSM 116 P+ + A+ + + I L + + +S+ ++ G+ L++ Sbjct: 247 PN-RYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYT 305 Query: 117 DESIKIWDTLNGS 129 D I++W + Sbjct: 306 DNVIRVWGVSENA 318 >5I2T-A nrPDB Length = 742 Score = 158 bits (399), Expect = 3e-39, Method: Composition-based stats. Identities = 60/270 (22%), Positives = 118/270 (43%), Gaps = 23/270 (8%) Query: 15 KATCAKISPDGQFLAITQGL--NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIAT 72 ++ G++LA +L+Y+ + H + L +SPDG + T Sbjct: 329 PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYI-LKQQGHFDSTNSLAYSPDGSRVVT 387 Query: 73 ASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 131 AS+D +++ ++ G L TF HT+ V ++ F ++G ++F+SS+D +++ WD + Sbjct: 388 ASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNF 447 Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGL-IRIFDAETGHCLKTLTYDKDWKRENGVV 190 +T + + ++ +GS D I ++ +TG L L+ + Sbjct: 448 RTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEG-------- 499 Query: 191 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 P+S + FS+ L S D ++IW G R+ QV+P+E + L+ Sbjct: 500 PVSCLSFSQENSVLASASWDKTIRIWSIFG----RSQQVEPIE-----VYSDVLALSMRP 550 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLD 280 + +S + G I +N + + +D Sbjct: 551 DGKEVAVSTLK-GQISIFNIEDAKQVGNID 579 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 108/272 (39%), Gaps = 23/272 (8%) Query: 44 RTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGH-TAPVISL 102 R + ++ + + P + +A + L L + PV ++ Sbjct: 274 RITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTV 333 Query: 103 TFNRKGNLL-FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDG 161 + N+ G L F SS + +++ + S + H ++ S+ D S + + S DG Sbjct: 334 SVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSP-DGSRVVTASEDG 392 Query: 162 LIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 I+++D +G CL T ++ V+F++ + + SLDG V+ WD I Sbjct: 393 KIKVWDITSGFCLATFEEHT--------SSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRY 444 Query: 222 CVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY-ENGDIYCWNSDTKSLLQLLD 280 RTF + +C D S +V +G +N DI+ W+ T LL L Sbjct: 445 RNFRTFTGTER----IQFNCL-----AVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALS 495 Query: 281 GSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 G + +S +++ S + + +W Sbjct: 496 G--HEGPVSCLSFSQENSVLASASWDKTIRIW 525 Score = 103 bits (257), Expect = 9e-23, Method: Composition-based stats. Identities = 59/362 (16%), Positives = 110/362 (30%), Gaps = 76/362 (20%) Query: 19 AKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 ++ G L +I + ++ + R V S + +SPDG+ A AS F Sbjct: 86 IDLNKQGTLLISIDEDGRAILVNFKARNVLHHFN--FKEKCSAVKFSPDGRLFALASGRF 143 Query: 78 SVEIIHLSY-GLLHTFI---------GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 ++I F GH + SLT+++ + T+S D S KIW + Sbjct: 144 -LQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDS 202 Query: 128 GS---LMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG------------- 171 T + H + V+ + + + S DG + +++ Sbjct: 203 EEKNLAATTFNGHRDYVMGAFFSHDQEK-IYTVSKDGAVFVWEFTKRPSDDDDNESEDDD 261 Query: 172 HCLKTLTYDKDWKRE------NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR 225 + W+ + V F R L V G +++D +++ Sbjct: 262 KQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQ 321 Query: 226 TFQVQPLEKGVL-----------------------------------HHSCGMDFLNPED 250 + + H D Sbjct: 322 QLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPD 381 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 GS V++ E+G I W+ + L + + S + G +M S +L+G Sbjct: 382 GSR--VVTASEDGKIKVWDITSGFCLATFEE--HTSSVTAVQFAKRGQVMFSSSLDGTVR 437 Query: 311 LW 312 W Sbjct: 438 AW 439 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 50/340 (14%), Positives = 116/340 (34%), Gaps = 39/340 (11%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 F+F +GT S DG+ L G + ++D+ S T H + + + Sbjct: 30 FKFSNLLGTVYRQGN--ITFSDDGKQLLSPVGNRVSVFDLINNK-SFTFEYEHRKNIAAI 86 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 121 + G + + +D +++ + ++ F+ G L +S ++ Sbjct: 87 DLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQ 145 Query: 122 IWDTLN---------GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 IW T + + + H + + S+ + IL++ S D +I+ ++ Sbjct: 146 IWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTT-SKDLSAKIWSVDSEE 204 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCV--------- 223 T + FS + + S DG V +W+ Sbjct: 205 KNLAATT-----FNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESED 259 Query: 224 --------VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSL 275 + + + +K + + +T L+ G+ +G+ ++ +L Sbjct: 260 DDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTL 319 Query: 276 LQLLDGSLYHHSSPVMSIHCFGNIMCSLALN-GDCCLWRW 314 +Q L S+ + +S++ G + + G ++ W Sbjct: 320 IQQL--SMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEW 357 >3FM0-A nrPDB Length = 345 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 66/323 (20%), Positives = 118/323 (36%), Gaps = 34/323 (10%) Query: 17 TCAKISPDGQFLA-ITQGLNILIY--DINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 +P G LA I I+ + + L H R ++ WSP G +A+A Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79 Query: 74 SDDFSVEIIHLS---YGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT---LN 127 S D + I + + + T GH V S+ + GNLL T S D+S+ +W+ Sbjct: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH--CLKTLTYDKDWKR 185 + +++H++ V V V +L+S SYD ++++ E C TL + Sbjct: 140 YECVSVLNSHTQDVKHV-VWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHE---- 194 Query: 186 ENGVVPISQVKFSENARYLLVKSLDGVVKIWD--CIGGCVVRTFQVQPLEKGVLHHSCGM 243 + + F + + L S D V+IW G + G Sbjct: 195 ----STVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGF 250 Query: 244 DFLNPEDGS----TPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHH-------SSPVMS 292 D + T + + + I + D S Q SL H ++ Sbjct: 251 HSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVA 310 Query: 293 IHCFGN-IMCSLALNGDCCLWRW 314 + ++ S + +G+ W++ Sbjct: 311 WNPKEPGLLASCSDDGEVAFWKY 333 Score = 67.1 bits (162), Expect = 9e-12, Method: Composition-based stats. Identities = 31/189 (16%), Positives = 64/189 (33%), Gaps = 22/189 (11%) Query: 130 LMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF--DAETGHCLKTLTYDKDWKREN 187 L+ + AH ++ ++L+S D IRI+ + ++ C L+ E Sbjct: 7 LLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-------EG 59 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLN 247 + +V +S YL S D IW ++ E V + Sbjct: 60 HQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWA----- 114 Query: 248 PEDGSTPLVISGYENGDIYCWNS---DTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLA 304 S L+ + + ++ W D + +L+ + + H ++ S + Sbjct: 115 ---PSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNS--HTQDVKHVVWHPSQELLASAS 169 Query: 305 LNGDCCLWR 313 + L+R Sbjct: 170 YDDTVKLYR 178 >5Y88-O nrPDB Length = 451 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 125/314 (39%), Gaps = 32/314 (10%) Query: 11 QNGLKAT--CAKISP--DGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD 66 NG C I P + F+ + + ++D+ + +T + H ++ S Sbjct: 135 INGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKL-KTTLAGHVMTVRDVAVSDR 193 Query: 67 GQCIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT 125 + + S+D +V+ L + + GH + V +++ + +L+ T+ D IK+WD Sbjct: 194 HPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDM 253 Query: 126 LNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKR 185 + T+ H + V D ++SS S D +R++D G +K LT+ K R Sbjct: 254 RTRIPVITLVGHKGPINQVQCTPVDPQVVSS-STDATVRLWDVVAGKTMKVLTHHKRSVR 312 Query: 186 ENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF 245 + P +FS + D ++ W G ++ F+ + + ++ Sbjct: 313 ATALHPK---EFS-----VASACTDD-IRSWGLAEGSLLTNFESEK--------TGIINT 355 Query: 246 LNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLL-----DGSLYHHSSPVMS-IHCFGNI 299 L+ ++ +G +NG + ++ + Q L GSL S + S G Sbjct: 356 LSINQDD--VLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLR 413 Query: 300 MCSLALNGDCCLWR 313 + + + +W+ Sbjct: 414 LITGEADKSIKIWK 427 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 41/232 (17%), Positives = 75/232 (32%), Gaps = 23/232 (9%) Query: 82 IHLSYGLLHTFIGHTAPVISLTFNR-KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEA 140 H + L GH V + + T S D ++K+WD G L T++ H Sbjct: 125 WHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMT 184 Query: 141 VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN 200 V V V + S S D ++ +D E ++ + + V Sbjct: 185 VRDVAVSDRHPYLFSV-SEDKTVKCWDLEKNQIIRDYYGH--------LSGVRTVSIHPT 235 Query: 201 ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY 260 + D V+K+WD V T + + P V+S Sbjct: 236 LDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPV----------DPQVVSSS 285 Query: 261 ENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + + W+ +++L + + S ++H + S + D W Sbjct: 286 TDATVRLWDVVAGKTMKVL--THHKRSVRATALHPKEFSVASACTD-DIRSW 334 Score = 50.9 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 22/129 (17%), Positives = 41/129 (31%), Gaps = 12/129 (9%) Query: 5 VTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWS 64 V T + + P +A +I + + ++ + + L + Sbjct: 300 TMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGIINTLSIN 359 Query: 65 PDGQCIATASDDFSVEIIHLSYGLLHT----------FIGHTAPVISLTFNRKGNLLFTS 114 D + D+ + G + G V+ TF++ G L T Sbjct: 360 QD-DVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEG-ERSVLCSTFDKTGLRLITG 417 Query: 115 SMDESIKIW 123 D+SIKIW Sbjct: 418 EADKSIKIW 426 >5UZ7-B nrPDB Length = 351 Score = 155 bits (391), Expect = 2e-38, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 97/257 (37%), Gaps = 23/257 (8%) Query: 18 CAKISPDGQFLAITQGLNIL-IYDINRRTVSQTL---VTSHARPFSELCWSPDGQCIATA 73 +P G ++A NI IY++ R + + + H S + D Q I T+ Sbjct: 113 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTS 171 Query: 74 SDDFSVEIIHLSYGLLHTFIG-HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK 132 S D + + + G T HT V+SL+ L + + D S K+WD G + Sbjct: 172 SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ 231 Query: 133 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 T + H + ++ N + ++GS D R+FD L T ++D N + I Sbjct: 232 TFTGHESDINAICFFPN-GNAFATGSDDATCRLFDLRADQELMTYSHD------NIICGI 284 Query: 193 SQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGS 252 + V FS++ R LL D +WD + L + Sbjct: 285 TSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVT----------DD 334 Query: 253 TPLVISGYENGDIYCWN 269 V +G + + WN Sbjct: 335 GMAVATGSWDSFLKIWN 351 Score = 152 bits (383), Expect = 2e-37, Method: Composition-based stats. Identities = 52/291 (17%), Positives = 109/291 (37%), Gaps = 26/291 (8%) Query: 27 FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY 86 ++ +Q ++I+D + + ++P G +A D I +L Sbjct: 81 LVSASQDGKLIIWDSYTTNKVHAI-PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT 139 Query: 87 G-----LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAV 141 + GHT + F N + TSS D + +WD G T + H+ V Sbjct: 140 REGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDV 198 Query: 142 VSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA 201 +S+ + D+ + SG+ D +++D G C +T T + I+ + F N Sbjct: 199 MSLSLAP-DTRLFVSGACDASAKLWDVREGMCRQTFTGHESD--------INAICFFPNG 249 Query: 202 RYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE 261 S D +++D + T+ + G+ S S L+++GY+ Sbjct: 250 NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK--------SGRLLLAGYD 301 Query: 262 NGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + + W++ +L G + + + + G + + + + +W Sbjct: 302 DFNCNVWDALKADRAGVLAG--HDNRVSCLGVTDDGMAVATGSWDSFLKIW 350 Score = 124 bits (310), Expect = 7e-29, Method: Composition-based stats. Identities = 42/205 (20%), Positives = 80/205 (39%), Gaps = 15/205 (7%) Query: 17 TCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 +C + D Q + + ++DI + T T H L +PD + + + D Sbjct: 158 SCCRFLDDNQIVTSSGDTTCALWDIETGQQTTT-FTGHTGDVMSLSLAPDTRLFVSGACD 216 Query: 77 FSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 S ++ + G+ TF GH + + ++ F GN T S D + +++D + T S Sbjct: 217 ASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS 276 Query: 136 AHSE---AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 H + SV +L +G D ++DA L + + Sbjct: 277 -HDNIICGITSVSFSK-SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNR--------V 326 Query: 193 SQVKFSENARYLLVKSLDGVVKIWD 217 S + +++ + S D +KIW+ Sbjct: 327 SCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 104 bits (260), Expect = 4e-23, Method: Composition-based stats. Identities = 37/230 (16%), Positives = 80/230 (34%), Gaps = 18/230 (7%) Query: 83 HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVV 142 + T GH A + ++ + LL ++S D + IWD+ + + I S V+ Sbjct: 53 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM 112 Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR 202 + + ++ G D + I++ +T ++ + +S +F ++ Sbjct: 113 TCAYAP-SGNYVACGGLDNICSIYNLKTREGNVRVS----RELAGHTGYLSCCRFLDDN- 166 Query: 203 YLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN 262 ++ S D +WD + H+ + L+ T L +SG + Sbjct: 167 QIVTSSGDTTCALWDI---------ETGQQTTTFTGHTGDVMSLSLA-PDTRLFVSGACD 216 Query: 263 GDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 W+ Q G + + GN + + + C L+ Sbjct: 217 ASAKLWDVREGMCRQTFTG--HESDINAICFFPNGNAFATGSDDATCRLF 264 >5Z56-q nrPDB Length = 504 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 52/293 (17%), Positives = 107/293 (36%), Gaps = 24/293 (8%) Query: 22 SPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEI 81 S + L N++++D + + TL H + + + + P + +AS D ++ I Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLK-GHTKKVTSVVFHPSQDLVFSASPDATIRI 290 Query: 82 IHLSY-GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEA 140 + + H + V L+ + G+ L +SS D+ D G ++ ++ + Sbjct: 291 WSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG 350 Query: 141 VV-SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE 199 + D I +G+ D I+I+D + + PI+ + FSE Sbjct: 351 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG--------PITSIAFSE 402 Query: 200 NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 259 N YL + D VK+WD +T Q+ + D S + G Sbjct: 403 NGYYLATAADDSSVKLWDLRKLKNFKTLQLDN------NFEVKSLIF---DQSGTYLALG 453 Query: 260 YENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + IY K ++L + + + ++ + S ++ + Sbjct: 454 GTDVQIYI----CKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502 Score = 148 bits (373), Expect = 3e-36, Method: Composition-based stats. Identities = 51/277 (18%), Positives = 100/277 (36%), Gaps = 23/277 (8%) Query: 40 DINRRTVSQTLVTSHARPF-----SELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIG 94 ++++ + V H+ +LC S + + +D V S +L T G Sbjct: 203 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKG 262 Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSIL 154 HT V S+ F+ +L+F++S D +I+IW N S ++ + AH AV + + +L Sbjct: 263 HTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLL 322 Query: 155 SSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVK 214 SS S D D +TG L +T + ++ +F + ++D +K Sbjct: 323 SS-SDDQYWAFSDIQTGRVLTKVTDETSG------CSLTCAQFHPDGLIFGTGTMDSQIK 375 Query: 215 IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS 274 IWD V F + S + + + ++ + W+ Sbjct: 376 IWDLKERTNVANFPGHSGPITSIAFS----------ENGYYLATAADDSSVKLWDLRKLK 425 Query: 275 LLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCL 311 + L + + G + + + Sbjct: 426 NFKTLQ-LDNNFEVKSLIFDQSGTYLALGGTDVQIYI 461 Score = 98.7 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 43/173 (24%), Positives = 70/173 (40%), Gaps = 14/173 (8%) Query: 3 QFVTPVGTQ-NGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSE 60 + +T V + +G TCA+ PDG T I I+D+ RT H+ P + Sbjct: 339 RVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF-PGHSGPITS 397 Query: 61 LCWSPDGQCIATASDDFSVEIIHLSY-GLLHTFIGHTA-PVISLTFNRKGNLLFTSSMDE 118 + +S +G +ATA+DD SV++ L T V SL F++ G L D Sbjct: 398 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDV 457 Query: 119 SIKI---WDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 I I W + + + HS V + ++S D ++ + Sbjct: 458 QIYICKQW-----TEILHFTEHSGLTTGVAFGH-HAKFIASTGMDRSLKFYSL 504 >5OQL-L nrPDB Length = 557 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 56/305 (18%), Positives = 116/305 (38%), Gaps = 42/305 (13%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTL----VTSHARP 57 F +GT + ++ + A+T G + I+ I +R +T+ +H Sbjct: 47 ISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGE 106 Query: 58 FSELCWSPDGQCIATASDDFSVEIIHLSYG----LLHTFIGHTAPVISLTFNRKG-NLLF 112 PDG+ + D +++ + G +L T+ H PV ++ L Sbjct: 107 IR-----PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLM 161 Query: 113 TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN--DSSILSSGSYDGLIRIFDAET 170 + S D+++++WD + + + H++ V +S++L SGSYD +R++DA Sbjct: 162 SCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARA 221 Query: 171 -GHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQV 229 G + T PI V + LL S + + D + +R Sbjct: 222 PGGAVMTF---------KHADPIEDVLPLPSGTTLLAASG-NAISVLDLVAAKPLRLITN 271 Query: 230 QPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSP 289 L + V+SG +G + + + + +++ + + SP Sbjct: 272 HQKTVTSLSLAS----------QGRRVVSGSLDGHVKVFETTSWNVV-----AGAKYPSP 316 Query: 290 VMSIH 294 ++S+ Sbjct: 317 ILSLS 321 Score = 64.8 bits (156), Expect = 4e-11, Method: Composition-based stats. Identities = 26/178 (14%), Positives = 58/178 (32%), Gaps = 15/178 (8%) Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 + V S V ++ L + + + IF LKT+ + E I Sbjct: 54 GTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTI---GRFDSEAHCGEIR-- 108 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 + R L+ G ++++D G + + K + + Sbjct: 109 ---PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKW------SPTELTT 159 Query: 256 VISGYENGDIYCWNSDTKSLLQLLDG-SLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 ++S ++ + W+ + +L G + Y M N++ S + + +W Sbjct: 160 LMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVW 217 Score = 47.1 bits (110), Expect = 9e-06, Method: Composition-based stats. Identities = 18/97 (18%), Positives = 39/97 (40%), Gaps = 6/97 (6%) Query: 23 PDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII 82 P G L G I + D+ + L+T+H + + L + G+ + + S D V++ Sbjct: 242 PSGTTLLAASGNAISVLDLVAAKPLR-LITNHQKTVTSLSLASQGRRVVSGSLDGHVKVF 300 Query: 83 HLSYGLLHTFIGHTAPVISLTF-----NRKGNLLFTS 114 + + + +P++SL+ + L Sbjct: 301 ETTSWNVVAGAKYPSPILSLSVITAGASHDDRHLAVG 337 >3JB9-L nrPDB Length = 340 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 45/268 (16%), Positives = 107/268 (39%), Gaps = 27/268 (10%) Query: 53 SHARPFSELCWSPDGQCIATASDDFSVEIIHL--SYGLLHTFIGHTAPVISLTFNRKGNL 110 H + P G A+ D + + ++ G + L ++R + Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRV 107 Query: 111 LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET 170 ++ SS D + WD ++G ++ H+ V ++DV S +L+S S D ++++D+ + Sbjct: 108 VYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRS 167 Query: 171 GHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ 230 C+KT+ P++ V ++ + + +DG +KIWD + Sbjct: 168 KDCIKTIEEK---------YPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKG- 217 Query: 231 PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS----DTKSLLQLLDGSLYHH 286 H +DGS+ ++S + + ++ + LQ+ +G+++ Sbjct: 218 -------HKDIITSLAISKDGSS--LLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQ 268 Query: 287 SSPVMSIHCFGN--IMCSLALNGDCCLW 312 ++ + N + + + + + +W Sbjct: 269 EHNLLGVAWSRNSRFVGAGSSDKNVYVW 296 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 123/298 (41%), Gaps = 20/298 (6%) Query: 18 CAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 A+ P G + A IL++++ + ++ ++L WS D + + +S D Sbjct: 55 VARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSD 114 Query: 77 FSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTS-SMDESIKIWDTLNGSLMKTI 134 + G + GH V +L + G+ L TS S D ++K+WD+ + +KTI Sbjct: 115 THLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTI 174 Query: 135 SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ 194 + +V + + + G DG I+I+D HC L KD I+ Sbjct: 175 E-EKYPLTAVAIAQQGTQVFI-GGIDGAIKIWDLRNNHCSHVLKGHKDI--------ITS 224 Query: 195 VKFSENARYLLVKSLDGVVKIWDCIG-GCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGST 253 + S++ LL S+D V+I+D R Q+ H+ + ++ Sbjct: 225 LAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSR---NS 281 Query: 254 PLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCL 311 V +G + ++Y W++ T L +L G + S + H +I+ S + + L Sbjct: 282 RFVGAGSSDKNVYVWSA-TGDLRYVLPG--HEGSVNHVDFHPHQDIILSCSSDRTIFL 336 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 45/114 (39%), Gaps = 8/114 (7%) Query: 17 TCAKISPDGQ-FLAITQGLNILIYDINRRTVSQTLV-------TSHARPFSELCWSPDGQ 68 T IS DG L+ + + I+D+ +Q + + WS + + Sbjct: 223 TSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSR 282 Query: 69 CIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 + S D +V + + L + GH V + F+ +++ + S D +I + Sbjct: 283 FVGAGSSDKNVYVWSATGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTIFL 336 >3JB9-g nrPDB Length = 558 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 105/270 (38%), Gaps = 26/270 (9%) Query: 53 SHARPFSELCWSP-DGQCIATASDDFSVEIIHL--SYGLLHTFIGHTAPVISLTFNRKGN 109 H + S L + P G + + S D ++I + LL TF GH P+ L+F++ G Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGR 323 Query: 110 LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDV--PMNDSSILSSGSYDGLIRIFD 167 ++S D++IK+WDT G + ++ V + + +G+ D I FD Sbjct: 324 SFLSTSFDKTIKLWDTELGKCLNCFNS-DRLTNCVKFQVDPDKPNEFLAGTADKRILQFD 382 Query: 168 AETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 + ++ + + I+ + F EN + + S D ++ W+ ++ Sbjct: 383 IRSPDIVQAYDHH--------LGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIK-- 432 Query: 228 QVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTK---SLLQLLDGSLY 284 + HS L P S + + IY +++ K + ++ G Sbjct: 433 ----FVADIAMHSMPRVALRPNGKS---IACQSLDNCIYVYSAYEKYRQNKKKVFKGYSC 485 Query: 285 HHSSPVMSIHCFGNIMCSLALNGDCCLWRW 314 S + G + S +G+ C W W Sbjct: 486 SGYSLEVGFSPDGRFVFSGDSSGNACFWDW 515 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 54/306 (17%), Positives = 109/306 (35%), Gaps = 28/306 (9%) Query: 17 TCAKISPDG--QFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 74 +C + P L+ + I I+++ HARP +L +S DG+ + S Sbjct: 270 SCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTS 329 Query: 75 DDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRK---GNLLFTSSMDESIKIWDTLNGSLM 131 D ++++ G + F N + D+ I +D + ++ Sbjct: 330 FDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIV 389 Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 191 + H + S+ N +++ S D +R ++ T +K + + + Sbjct: 390 QAYDHHLGGINSITFLENGKRFVTT-SDDSSMRFWEYGTPVPIK-------FVADIAMHS 441 Query: 192 ISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPE-D 250 + +V N + + +SLD + ++ Q +K +SC L Sbjct: 442 MPRVALRPNGKSIACQSLDNCIYVYSAYEKYR------QNKKKVFKGYSCSGYSLEVGFS 495 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF---GNIMCSLAL-N 306 V SG +G+ W+ T L L HS PV S+ + + + ++ + Sbjct: 496 PDGRFVFSGDSSGNACFWDWKT----CKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVD 551 Query: 307 GDCCLW 312 G W Sbjct: 552 GSIKYW 557 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 46/236 (19%), Positives = 93/236 (39%), Gaps = 26/236 (11%) Query: 82 IHLSYGLLHTFIGHTAPVISLTFNR-KGNLLFTSSMDESIKIWDTLN-GSLMKTISAHSE 139 ++ + T+ GHT + L F G+LL + SMD IKIW+ + SL++T H+ Sbjct: 252 CYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHAR 311 Query: 140 AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF-- 197 + + + S LS+ S+D I+++D E G CL D+ + VKF Sbjct: 312 PIRDLSFSQDGRSFLST-SFDKTIKLWDTELGKCLNCFNSDRLT---------NCVKFQV 361 Query: 198 -SENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLV 256 + L + D + +D +V+ + + + Sbjct: 362 DPDKPNEFLAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFL----------ENGKRF 411 Query: 257 ISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 ++ ++ + W T ++ + HS P +++ G + +L+ ++ Sbjct: 412 VTTSDDSSMRFWEYGTPVPIK-FVADIAMHSMPRVALRPNGKSIACQSLDNCIYVY 466 >5WYJ-BC nrPDB Length = 817 Score = 150 bits (378), Expect = 9e-37, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 110/259 (42%), Gaps = 20/259 (7%) Query: 27 FLAITQGLNILIY---------DINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 L + L I + D+ VS+ +H + + L SP+ ATAS D Sbjct: 454 LLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDK 513 Query: 78 SVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA 136 + +I +L G L T H + ++F + LL TSS D+++KIW S+MKT+ Sbjct: 514 TCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEG 573 Query: 137 HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK 196 H+ AV ++S G+ DGLI+I+D +G CLKTL + + + Sbjct: 574 HTNAVQRCSFINKQKQLISCGA-DGLIKIWDCSSGECLKTLDGHNNR--------LWALS 624 Query: 197 FSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLV 256 + ++ DGV + W + Q + + ++++ D + + Sbjct: 625 TMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQ-EQSLQNYMSKGDWTNAFL 683 Query: 257 ISGYENGDIYCWNSDTKSL 275 ++ + + +N ++L Sbjct: 684 LAMTLDHPMRLFNVLKRAL 702 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 112/285 (39%), Gaps = 41/285 (14%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLH-----TFIGHTAPVISLT 103 + H + L + DG IATAS D + + + +IGH+A V ++ Sbjct: 382 EIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVG 441 Query: 104 FNR-----KGNLLFTSSMDESIKIWDTLNGSL----------MKTISAHSEAVVSVDVPM 148 L T+S D +IK W + T AH + + ++ V Sbjct: 442 LPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP 501 Query: 149 NDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKS 208 NDS I ++ SYD +I++ E G TL K + V F + + L S Sbjct: 502 NDS-IFATASYDKTCKIWNLENGELEATLANHKR--------GLWDVSFCQYDKLLATSS 552 Query: 209 LDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 D VKIW V++T + G + F+N + +IS +G I W Sbjct: 553 GDKTVKIWSLDTFSVMKTLE------GHTNAVQRCSFINKQ----KQLISCGADGLIKIW 602 Query: 269 NSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWR 313 + + L+ LDG +++ +S G+++ S +G W+ Sbjct: 603 DCSSGECLKTLDG--HNNRLWALSTMNDGDMIVSADADGVFQFWK 645 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 118/296 (39%), Gaps = 19/296 (6%) Query: 7 PVGTQNGLKATCAKISPDGQFLAITQGLNILIYDIN--RRTVSQTLVTSHARPFSELCWS 64 + + A +S +G+ LA I I D+ R + + + + L + Sbjct: 11 SLNPIYAGSSAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLT 70 Query: 65 PDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 PDGQ + S ++I HL G + + ++P L + LL D SI + D Sbjct: 71 PDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVD 130 Query: 125 TLNGSLMKTISAHSEAVVSVDVP-MNDSSI--LSSGSYDGLIRIFDAETGHCLKTLTYDK 181 NG + + H + S+ +S I L+SG +G+++++D CL TL Sbjct: 131 IENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHT 190 Query: 182 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 R G+ I E + LL D ++ +WD + + P+ + V SC Sbjct: 191 SAVR--GLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQV--ESC 246 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFG 297 G FL DG ++ + + +S++ S+L+ + P+ + G Sbjct: 247 G--FLKDGDGK-RIIYTAGGDAIFQLIDSESGSVLK-------RTNKPIEELFIIG 292 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 62/373 (16%), Positives = 133/373 (35%), Gaps = 67/373 (17%) Query: 3 QFVTPVGTQNGLKATCAKISPDGQFLA-ITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 + + + ++ + T K++PDGQ+L ++Q + I+ + V +++ S + Sbjct: 51 KILHKISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDA 110 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTF----NRKGNLLFTSSM 116 +A D S+ ++ + G + H+F GH + SL F N K LL + Sbjct: 111 D--STSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDT 168 Query: 117 DESIKIWDTLNGSLMKTISAHSEAVVSVDV---PMNDSS--ILSSGSYDGLIRIFDAETG 171 + +K+WD + + T+ H+ AV +D+ P ND L SG D +I ++D Sbjct: 169 NGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFN-- 226 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLL-VKSLDGVVKIWDCIGGCVV------ 224 +K N V + + ++ D + ++ D G V+ Sbjct: 227 --MKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKP 284 Query: 225 ------------------------RTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS-- 258 +T Q+ +E+ + + + + G+ ++ Sbjct: 285 IEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMR 344 Query: 259 -----------GYENGDIYCW---NSDTKSLLQLLDGSLY-HHSSPVMSIHC--FGNIMC 301 + + + LD +Y H + S+ G + Sbjct: 345 YVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIA 404 Query: 302 SLALNGDCCLWRW 314 + + + +WR+ Sbjct: 405 TASKDNTAIVWRY 417 Score = 74.8 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 25/188 (13%), Positives = 60/188 (31%), Gaps = 14/188 (7%) Query: 131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLT----YDKDWKRE 186 ++ H + + S+D D +++ S D ++ C + Sbjct: 381 VEIYEGHEDLLNSLDA-TEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTA 439 Query: 187 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 246 G+ I + E +LL S D +K W Q+ + + H Sbjct: 440 VGLPNIVSKGYPE---FLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINA 496 Query: 247 NPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPV--MSIHCFGNIMCSLA 304 + + + + WN + L+ +L +H + +S + ++ + + Sbjct: 497 LSVSPNDSIFATASYDKTCKIWNLENGE----LEATLANHKRGLWDVSFCQYDKLLATSS 552 Query: 305 LNGDCCLW 312 + +W Sbjct: 553 GDKTVKIW 560 Score = 70.2 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 58/271 (21%), Positives = 102/271 (37%), Gaps = 31/271 (11%) Query: 40 DINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGH---- 95 D+ +L +A + S +G+ +AT D + II L+ G H Sbjct: 2 DLKTSYKGISLNPIYAGSSAVATVSENGKILATPVLD-EINIIDLTPGSRKIL--HKISN 58 Query: 96 --TAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 + +L G L S + +KI+ G +++++ S +D S++ Sbjct: 59 EDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKI-SSPSYILDADST-STL 116 Query: 154 LSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE--NARYLLVKSLD- 210 L+ G DG I + D E G+ + IS +KF N++ L+ S D Sbjct: 117 LAVGGTDGSIIVVDIENGYITHSFKGHGGT--------ISSLKFYGQLNSKIWLLASGDT 168 Query: 211 -GVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLV--ISGYENGDIYC 267 G+VK+WD + + T Q G+D + D P + +SG + I Sbjct: 169 NGMVKVWDLVKRKCLHTLQEH------TSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINL 222 Query: 268 WNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN 298 W+ + K +LL + G+ Sbjct: 223 WDFNMKKKCKLLKTLPVNQQVESCGFLKDGD 253 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 40/101 (39%), Gaps = 2/101 (1%) Query: 24 DGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIH 83 D + + I+ ++ +V +TL H + + + + D ++I Sbjct: 545 DKLLATSSGDKTVKIWSLDTFSVMKTL-EGHTNAVQRCSFINKQKQLISCGADGLIKIWD 603 Query: 84 LSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 S G L T GH + +L+ G+++ ++ D + W Sbjct: 604 CSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 27/79 (34%), Gaps = 4/79 (5%) Query: 8 VGTQNGLKAT---CAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWS 64 + T G C+ I+ Q ++ I I+D + +TL H L Sbjct: 568 MKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTL-DGHNNRLWALSTM 626 Query: 65 PDGQCIATASDDFSVEIIH 83 DG I +A D + Sbjct: 627 NDGDMIVSADADGVFQFWK 645 >4LG8-A nrPDB Length = 354 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 52/293 (17%), Positives = 107/293 (36%), Gaps = 24/293 (8%) Query: 22 SPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEI 81 S + L N++++D + + TL H + + + + P + +AS D ++ I Sbjct: 82 SDTNKILTGGADKNVVVFDKSSEQILATLK-GHTKKVTSVVFHPSQDLVFSASPDATIRI 140 Query: 82 IHLSY-GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEA 140 + + H + V L+ + G+ L +SS D+ D G ++ ++ + Sbjct: 141 WSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG 200 Query: 141 VV-SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE 199 + D I +G+ D I+I+D + + PI+ + FSE Sbjct: 201 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG--------PITSIAFSE 252 Query: 200 NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 259 N YL + D VK+WD +T Q+ + D S + G Sbjct: 253 NGYYLATAADDSSVKLWDLRKLKNFKTLQLDN------NFEVKSLIF---DQSGTYLALG 303 Query: 260 YENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + IY K ++L + + + ++ + S ++ + Sbjct: 304 GTDVQIYI----CKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 352 Score = 142 bits (359), Expect = 1e-34, Method: Composition-based stats. Identities = 51/277 (18%), Positives = 100/277 (36%), Gaps = 23/277 (8%) Query: 40 DINRRTVSQTLVTSHARPF-----SELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIG 94 ++++ + V H+ +LC S + + +D V S +L T G Sbjct: 53 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKG 112 Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSIL 154 HT V S+ F+ +L+F++S D +I+IW N S ++ + AH AV + + +L Sbjct: 113 HTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLL 172 Query: 155 SSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVK 214 SS S D D +TG L +T + ++ +F + ++D +K Sbjct: 173 SS-SDDQYWAFSDIQTGRVLTKVTDETSG------CSLTCAQFHPDGLIFGTGTMDSQIK 225 Query: 215 IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS 274 IWD V F + S + + + ++ + W+ Sbjct: 226 IWDLKERTNVANFPGHSGPITSIAFS----------ENGYYLATAADDSSVKLWDLRKLK 275 Query: 275 LLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCL 311 + L + + G + + + Sbjct: 276 NFKTLQ-LDNNFEVKSLIFDQSGTYLALGGTDVQIYI 311 Score = 94.4 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 43/173 (24%), Positives = 70/173 (40%), Gaps = 14/173 (8%) Query: 3 QFVTPVGTQ-NGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSE 60 + +T V + +G TCA+ PDG T I I+D+ RT H+ P + Sbjct: 189 RVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF-PGHSGPITS 247 Query: 61 LCWSPDGQCIATASDDFSVEIIHLSY-GLLHTFIGHTA-PVISLTFNRKGNLLFTSSMDE 118 + +S +G +ATA+DD SV++ L T V SL F++ G L D Sbjct: 248 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDV 307 Query: 119 SIKI---WDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 I I W + + + HS V + ++S D ++ + Sbjct: 308 QIYICKQW-----TEILHFTEHSGLTTGVAFGH-HAKFIASTGMDRSLKFYSL 354 >6HHQ-h nrPDB Length = 319 Score = 147 bits (371), Expect = 5e-36, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 108/269 (40%), Gaps = 24/269 (8%) Query: 46 VSQTLVTSHARPFSELCWSP-DGQCIATASDDFSVEIIHLSYGL------LHTFIGHTAP 98 V + + H + L S + +AS D ++ L+ + +F GH+ Sbjct: 8 VLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHI 67 Query: 99 VISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS 158 V T G ++S D+++++WD G + H V+SVD+ S I+ SGS Sbjct: 68 VQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMII-SGS 126 Query: 159 YDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDC 218 D I+++ + G CL TL DW + VVP K +++ ++ D +VK W+ Sbjct: 127 RDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVP--NEKADDDSVTIISAGNDKMVKAWNL 183 Query: 219 IGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQL 278 + F + H+ ++ L T L+ S ++G+I WN K + Sbjct: 184 NQFQIEADF---------IGHNSNINTLTASPDGT-LIASAGKDGEIMLWNLAAKKAMYT 233 Query: 279 LDGSLYHHSSPVMSIHCFGNIMCSLALNG 307 L S ++ + + G Sbjct: 234 LSAQDEVFS---LAFSPNRYWLAAATATG 259 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 51/331 (15%), Positives = 120/331 (36%), Gaps = 41/331 (12%) Query: 3 QFVTPVGTQNGLKATCAKISPD----GQFLAITQGLNILIY----DINRRTVSQTLVTSH 54 + + GT G ++ L+ ++ ++ + D + V H Sbjct: 5 EVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGH 64 Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHT-FIGHTAPVISLTFNRKGNLLFT 113 + + + DG +AS D ++ + ++ G + F+GH + V+S+ ++K +++ + Sbjct: 65 SHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIIS 124 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN-----DSSILSSGSYDGLIRIFDA 168 S D++IK+W T+ G + T+ H++ V V V N DS + S D +++ ++ Sbjct: 125 GSRDKTIKVW-TIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNL 183 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 I+ + S + + DG + +W+ + T Sbjct: 184 NQFQIEADFIGHN--------SNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLS 235 Query: 229 VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSS 288 Q + + + + G I ++ D + L+ L +S Sbjct: 236 AQDEVFSLAF-----------SPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSK 283 Query: 289 P------VMSIHCFGNIMCSLALNGDCCLWR 313 ++ G + + + +W+ Sbjct: 284 AAEPHAVSLAWSADGQTLFAGYTDNVIRVWQ 314 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 37/267 (13%), Positives = 87/267 (32%), Gaps = 51/267 (19%) Query: 3 QFVTPVGTQNGLKATC--AKISPDGQF-LAITQGLNILIYDINRRTVSQTLVTSHARPFS 59 +F PV + G ++ DG + L+ + + ++D+ Q V H Sbjct: 53 KFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFV-GHKSDVM 111 Query: 60 ELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNR------KGNLLFT 113 + I + S D ++++ + L T +GH V + + + Sbjct: 112 SVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIIS 171 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 173 + D+ +K W+ + H+ + ++ D ++++S DG I +++ Sbjct: 172 AGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASP-DGTLIASAGKDGEIMLWNLAAKKA 230 Query: 174 LKTLTY-----------DKDWKRENGVVPIS----------------------------- 193 + TL+ ++ W I Sbjct: 231 MYTLSAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAV 290 Query: 194 QVKFSENARYLLVKSLDGVVKIWDCIG 220 + +S + + L D V+++W + Sbjct: 291 SLAWSADGQTLFAGYTDNVIRVWQVMT 317 >4AEZ-A nrPDB Length = 401 Score = 144 bits (363), Expect = 4e-35, Method: Composition-based stats. Identities = 56/292 (19%), Positives = 117/292 (40%), Gaps = 23/292 (7%) Query: 26 QFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLS 85 +A+ N+ +++ + +VS T + + + WS DG ++ + V+I + Sbjct: 105 NVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVE 164 Query: 86 YG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL-NGSLMKTISAHSEAVVS 143 L T GH A V L++NR ++L + S +I D + T+ HS V Sbjct: 165 SQTKLRTMAGHQARVGCLSWNR--HVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCG 222 Query: 144 VDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARY 203 + +D L+SG D +++I+DA + T T V ++ + N Sbjct: 223 LA-WRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNH-----NAAVKAVAWCPWQSNLLA 276 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENG 263 ++D + W+ G V T ++ + ++ G+ + Sbjct: 277 TGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTH---------GFPDN 327 Query: 264 DIYCWNSDTKSLLQLLDGSLYHHSSPVM--SIHCFGNIMCSLALNGDCCLWR 313 ++ W+ + L + +D + H + V+ ++ G I+ + A + + WR Sbjct: 328 NLSIWSYSSSGLTKQVD--IPAHDTRVLYSALSPDGRILSTAASDENLKFWR 377 Score = 137 bits (344), Expect = 8e-33, Method: Composition-based stats. Identities = 50/274 (18%), Positives = 108/274 (39%), Gaps = 23/274 (8%) Query: 10 TQNGLKATCAKISPDGQFLAITQGLNIL-IYDINRRTVSQTLVTSHARPFSELCWSPDGQ 68 T K S DG FL++ G ++ IYD+ +T +T+ H L W+ Sbjct: 131 TDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMA-GHQARVGCLSWNRHVL 189 Query: 69 CIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 + S + ++ + T GH++ V L + G L + D ++IWD + Sbjct: 190 SSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSS 249 Query: 129 SLMKTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTLTYDKDWKRE 186 T + H+ AV +V S++L++ G+ D I ++A TG + T+ Sbjct: 250 IPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTV--------- 300 Query: 187 NGVVPISQVKFSENARYLLVKSL--DGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD 244 + ++ + +S +++ ++ D + IW + + + + VL+ + D Sbjct: 301 DAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPD 360 Query: 245 FLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQL 278 ++ + + ++ W ++ Sbjct: 361 --------GRILSTAASDENLKFWRVYDGDHVKR 386 Score = 54.8 bits (130), Expect = 4e-08, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 44/140 (31%), Gaps = 11/140 (7%) Query: 3 QFVTPVGTQNGLKATCAKISP-DGQFLAITQ---GLNILIYDINRRTVSQTLVTSHARPF 58 T + P LA I ++ T+ Sbjct: 249 SIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAG--SQV 306 Query: 59 SELCWSPDGQCIAT--ASDDFSVEIIHLSYGLLH---TFIGHTAPVISLTFNRKGNLLFT 113 + L WSP + I + D ++ I S L H V+ + G +L T Sbjct: 307 TSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILST 366 Query: 114 SSMDESIKIWDTLNGSLMKT 133 ++ DE++K W +G +K Sbjct: 367 AASDENLKFWRVYDGDHVKR 386 >5YZG-W nrPDB Length = 579 Score = 142 bits (359), Expect = 1e-34, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 109/292 (37%), Gaps = 23/292 (7%) Query: 27 FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY 86 L+ + I ++++ H++ ++C++ G +A+ D +++ Sbjct: 304 LLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTET 363 Query: 87 GLLHTFIGHTAPVISLTFNRKG---NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVS 143 G + + + FN NL D+ I WD +G +++ H AV + Sbjct: 364 GQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNT 423 Query: 144 VDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARY 203 + + +S+ S D +R+++ + + D + E + + V S N ++ Sbjct: 424 IVFVDENRRFVST-SDDKSLRVWEWD-------IPVDFKYIAEPSMHSMPAVTLSPNGKW 475 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENG 263 L +S+D + I+ + ++ V ++C +DF VISG NG Sbjct: 476 LACQSMDNQILIFGAQNRFRLNKKKIFKGH-MVAGYACQVDF----SPDMSYVISGDGNG 530 Query: 264 DIYCWNSDTKSLLQLLDGSLYHHSSPVMSI--HCFG-NIMCSLALNGDCCLW 312 + W+ T L H + H + + + +G LW Sbjct: 531 KLNIWDWKTTKLYSRF----KAHDKVCIGAVWHPHETSKVITCGWDGLIKLW 578 Score = 139 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 99/271 (36%), Gaps = 26/271 (9%) Query: 52 TSHARPFSELCWSP-DGQCIATASDDFSVEIIHL--SYGLLHTFIGHTAPVISLTFNRKG 108 + H + S + P G + + S D +++ + L TFIGH+ V + FN G Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344 Query: 109 NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS--SILSSGSYDGLIRIF 166 +++ D +K+WDT G + + + + V ++ ++ +G D I + Sbjct: 345 TQFLSAAYDRYLKLWDTETGQCISRFT-NRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQW 403 Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 D +G ++ + ++ + F + R + S D +++W+ Sbjct: 404 DIRSGEIVQEYDRH--------LGAVNTIVFVDENRRFVSTSDDKSLRVWE--------- 446 Query: 227 FQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLL---QLLDGSL 283 + + K + S + + + I + + + L ++ G + Sbjct: 447 WDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHM 506 Query: 284 YHHSSPVMSIHCFGNIMCSLALNGDCCLWRW 314 + + + + S NG +W W Sbjct: 507 VAGYACQVDFSPDMSYVISGDGNGKLNIWDW 537 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 91/238 (38%), Gaps = 26/238 (10%) Query: 80 EIIHLSYGLLHTFIGHTAPVISLT-FNRKGNLLFTSSMDESIKIWDT-LNGSLMKTISAH 137 E +L +H + GHT V ++ F G+LL + SMD IK+W+ ++T H Sbjct: 272 EKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGH 331 Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 S+AV + + L S +YD ++++D ETG C+ T K VKF Sbjct: 332 SKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVP---------YCVKF 381 Query: 198 SEN---ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTP 254 + + + D + WD G +V+ + + Sbjct: 382 NPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV----------DENR 431 Query: 255 LVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 +S ++ + W D + + HS P +++ G + +++ ++ Sbjct: 432 RFVSTSDDKSLRVWEWDIPVDFKYI-AEPSMHSMPAVTLSPNGKWLACQSMDNQILIF 488 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 44/213 (20%), Positives = 78/213 (36%), Gaps = 24/213 (11%) Query: 18 CAKISPD----GQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 C K +PD F+A I+ +DI + Q H + + + + + + Sbjct: 378 CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDR-HLGAVNTIVFVDENRRFVST 436 Query: 74 SDDFSVEIIHLSYGLLHTFIG----HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 SDD S+ + + +I H+ P ++T + G L SMD I I+ N Sbjct: 437 SDDKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRF 494 Query: 130 LM---KTISAH--SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 + K H + VD + S ++ SG +G + I+D +T Sbjct: 495 RLNKKKIFKGHMVAGYACQVDFSPDMSYVI-SGDGNGKLNIWDWKTTKLYSRFKAHDKVC 553 Query: 185 RENGVVPISQVKFSENARYLLVKSLDGVVKIWD 217 P ++ DG++K+WD Sbjct: 554 IGAVWHP-------HETSKVITCGWDGLIKLWD 579 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 67/185 (36%), Gaps = 19/185 (10%) Query: 131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA-ETGHCLKTLTYDKDWKRENGV 189 + S H++ V +V + +L S S D I++++ CL+T Sbjct: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSK------- 333 Query: 190 VPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPE 249 + + F+ L + D +K+WD G + F + + NP+ Sbjct: 334 -AVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKV--------PYCVKFNPD 384 Query: 250 DGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDC 309 + L ++G + I W+ + ++Q D L ++ V S + + Sbjct: 385 EDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIV--FVDENRRFVSTSDDKSL 442 Query: 310 CLWRW 314 +W W Sbjct: 443 RVWEW 447 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 26/161 (16%), Positives = 63/161 (39%), Gaps = 6/161 (3%) Query: 13 GLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIAT 72 G T + + +F++ + ++ +++ + + + + SP+G+ +A Sbjct: 419 GAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLAC 478 Query: 73 ASDDFSVEII----HLSYGLLHTFIGH--TAPVISLTFNRKGNLLFTSSMDESIKIWDTL 126 S D + I F GH + F+ + + + + + IWD Sbjct: 479 QSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWK 538 Query: 127 NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 167 L AH + + +++S + + +DGLI+++D Sbjct: 539 TTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 68.6 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 25/124 (20%), Positives = 47/124 (37%), Gaps = 7/124 (5%) Query: 8 VGTQNGLKATCAKISPDGQFLAI-TQGLNILIYDINR--RTVSQTLVTSH--ARPFSELC 62 + + +SP+G++LA + ILI+ R + + H A ++ Sbjct: 456 IAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVD 515 Query: 63 WSPDGQCIATASDDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNL-LFTSSMDESI 120 +SPD + + + + I L+ F H I ++ + T D I Sbjct: 516 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLI 575 Query: 121 KIWD 124 K+WD Sbjct: 576 KLWD 579 >6GMH-W nrPDB Length = 305 Score = 142 bits (359), Expect = 1e-34, Method: Composition-based stats. Identities = 60/212 (28%), Positives = 103/212 (48%), Gaps = 12/212 (5%) Query: 10 TQNGLKATCAKISPDGQFLAITQGL-NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQ 68 + A SPD Q+LA + + I+ + +L T + + +SPDG+ Sbjct: 103 DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDT-RGKFILSIAYSPDGK 161 Query: 69 CIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 +A+ + D + I ++ G LLHT GH P+ SLTF+ LL T+S D IKI+D + Sbjct: 162 YLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQH 221 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN 187 +L T+S H+ V++V +D+ +SS S ++++D T C+ T +D Sbjct: 222 ANLAGTLSGHASWVLNVAFCPDDTHFVSSSSD-KSVKVWDVGTRTCVHTFFDHQD----- 275 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCI 219 + VK++ N ++ D + I+DC Sbjct: 276 ---QVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304 Score = 120 bits (301), Expect = 7e-28, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 104/243 (42%), Gaps = 21/243 (8%) Query: 29 AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGL 88 + + +I ++D+ +++ L +SPD Q +AT + V I + G Sbjct: 81 SSSLDAHIRLWDLENGKQIKSIDAGPVDA-WTLAFSPDSQYLATGTHVGKVNIFGVESGK 139 Query: 89 -LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVP 147 ++ ++S+ ++ G L + ++D I I+D G L+ T+ H+ + S+ Sbjct: 140 KEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS 199 Query: 148 MNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK 207 DS +L + S DG I+I+D + + TL+ W + V F + + + Sbjct: 200 P-DSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW--------VLNVAFCPDDTHFVSS 250 Query: 208 SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYC 267 S D VK+WD V TF + + ++ G+ ++S ++ +I+ Sbjct: 251 SSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN----------GNGSKIVSVGDDQEIHI 300 Query: 268 WNS 270 ++ Sbjct: 301 YDC 303 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 53/250 (21%), Positives = 108/250 (43%), Gaps = 30/250 (12%) Query: 53 SHARPFSELCWSPD----GQCIATASDDFSVEIIHLSYGLLH---TFIGHTAPVISLTFN 105 +H + W + + + T S D V++ L + GH V+S+ + Sbjct: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDIS 73 Query: 106 RKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRI 165 + +SS+D I++WD NG +K+I A ++ DS L++G++ G + I Sbjct: 74 HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSP-DSQYLATGTHVGKVNI 132 Query: 166 FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR 225 F E+G +L + I + +S + +YL ++DG++ I+D G ++ Sbjct: 133 FGVESGKKEYSLDTRGKF--------ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLH 184 Query: 226 TFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYH 285 T + + L S + L+++ ++G I ++ + L G+L Sbjct: 185 TLEGHAMPIRSLTFSP----------DSQLLVTASDDGYIKIYDVQHAN----LAGTLSG 230 Query: 286 HSSPVMSIHC 295 H+S V+++ Sbjct: 231 HASWVLNVAF 240 Score = 112 bits (279), Expect = 2e-25, Method: Composition-based stats. Identities = 53/278 (19%), Positives = 102/278 (36%), Gaps = 25/278 (8%) Query: 23 PDGQFLAITQGLNILIYDI-NRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEI 81 + + + ++ + R Q + H + S A++S D + + Sbjct: 31 NSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRL 90 Query: 82 IHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEA 140 L G + + +L F+ L T + + I+ +G ++ + Sbjct: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKF 150 Query: 141 VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN 200 ++S+ D L+SG+ DG+I IFD TG L TL +PI + FS + Sbjct: 151 ILSIAYSP-DGKYLASGAIDGIINIFDIATGKLLHTLEGHA--------MPIRSLTFSPD 201 Query: 201 ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY 260 ++ L+ S DG +KI+D + T H S ++ D + +S Sbjct: 202 SQLLVTASDDGYIKIYDVQHANLAGTLSG--------HASWVLNVAFCPDDTH--FVSSS 251 Query: 261 ENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN 298 + + W+ T++ + H V + GN Sbjct: 252 SDKSVKVWDVGTRTCVHTFFD----HQDQVWGVKYNGN 285 Score = 40.9 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 33/87 (37%), Gaps = 4/87 (4%) Query: 2 FQFVTPVGTQNGLKATC--AKISPDGQ-FLAITQGLNILIYDINRRTVSQTLVTSHARPF 58 Q GT +G + PD F++ + ++ ++D+ RT T H Sbjct: 219 VQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFD-HQDQV 277 Query: 59 SELCWSPDGQCIATASDDFSVEIIHLS 85 + ++ +G I + DD + I Sbjct: 278 WGVKYNGNGSKIVSVGDDQEIHIYDCP 304 Score = 31.3 bits (69), Expect = 0.58, Method: Composition-based stats. Identities = 16/84 (19%), Positives = 31/84 (36%), Gaps = 4/84 (4%) Query: 231 PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPV 290 E+ + + + ++ V++G + + W + L L SL H V Sbjct: 10 KQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERL--DLQWSLEGHQLGV 67 Query: 291 MSIHCFG--NIMCSLALNGDCCLW 312 +S+ I S +L+ LW Sbjct: 68 VSVDISHTLPIAASSSLDAHIRLW 91 >6QDV-o nrPDB Length = 513 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 109/292 (37%), Gaps = 23/292 (7%) Query: 27 FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY 86 L+ + I ++++ H++ ++C++ G +A+ D +++ Sbjct: 238 LLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTET 297 Query: 87 GLLHTFIGHTAPVISLTFNRKG---NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVS 143 G + + + FN NL D+ I WD +G +++ H AV + Sbjct: 298 GQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNT 357 Query: 144 VDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARY 203 + + +S+ S D +R+++ + + D + E + + V S N ++ Sbjct: 358 IVFVDENRRFVST-SDDKSLRVWEWD-------IPVDFKYIAEPSMHSMPAVTLSPNGKW 409 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENG 263 L +S+D + I+ + ++ V ++C +DF VISG NG Sbjct: 410 LACQSMDNQILIFGAQNRFRLNKKKIFKGH-MVAGYACQVDF----SPDMSYVISGDGNG 464 Query: 264 DIYCWNSDTKSLLQLLDGSLYHHSSPVMSI--HCFG-NIMCSLALNGDCCLW 312 + W+ T L H + H + + + +G LW Sbjct: 465 KLNIWDWKTTKLYSRF----KAHDKVCIGAVWHPHETSKVITCGWDGLIKLW 512 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 41/271 (15%), Positives = 96/271 (35%), Gaps = 26/271 (9%) Query: 52 TSHARPFSELCWSP-DGQCIATASDDFSVEIIHL--SYGLLHTFIGHTAPVISLTFNRKG 108 + H + S + P G + + S D +++ + L TFIGH+ V + FN G Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 278 Query: 109 NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS--SILSSGSYDGLIRIF 166 +++ D +K+WDT G + + + + V ++ ++ +G D I + Sbjct: 279 TQFLSAAYDRYLKLWDTETGQCISRFT-NRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQW 337 Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 D +G ++ + ++ + F + R + S D +++W+ + Sbjct: 338 DIRSGEIVQEYDRH--------LGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKY 389 Query: 227 FQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLL---QLLDGSL 283 + + + + I + + + L ++ G + Sbjct: 390 IAEPSMHSMPAVTLS---------PNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHM 440 Query: 284 YHHSSPVMSIHCFGNIMCSLALNGDCCLWRW 314 + + + + S NG +W W Sbjct: 441 VAGYACQVDFSPDMSYVISGDGNGKLNIWDW 471 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 91/238 (38%), Gaps = 26/238 (10%) Query: 80 EIIHLSYGLLHTFIGHTAPVISLT-FNRKGNLLFTSSMDESIKIWDT-LNGSLMKTISAH 137 E +L +H + GHT V ++ F G+LL + SMD IK+W+ ++T H Sbjct: 206 EKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGH 265 Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 S+AV + + L S +YD ++++D ETG C+ T K VKF Sbjct: 266 SKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVP---------YCVKF 315 Query: 198 SEN---ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTP 254 + + + D + WD G +V+ + + Sbjct: 316 NPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV----------DENR 365 Query: 255 LVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 +S ++ + W D + + HS P +++ G + +++ ++ Sbjct: 366 RFVSTSDDKSLRVWEWDIPVDFKYI-AEPSMHSMPAVTLSPNGKWLACQSMDNQILIF 422 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 44/213 (20%), Positives = 78/213 (36%), Gaps = 24/213 (11%) Query: 18 CAKISPD----GQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 C K +PD F+A I+ +DI + Q H + + + + + + Sbjct: 312 CVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDR-HLGAVNTIVFVDENRRFVST 370 Query: 74 SDDFSVEIIHLSYGLLHTFIG----HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 SDD S+ + + +I H+ P ++T + G L SMD I I+ N Sbjct: 371 SDDKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRF 428 Query: 130 LM---KTISAH--SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 + K H + VD + S ++ SG +G + I+D +T Sbjct: 429 RLNKKKIFKGHMVAGYACQVDFSPDMSYVI-SGDGNGKLNIWDWKTTKLYSRFKAHDKVC 487 Query: 185 RENGVVPISQVKFSENARYLLVKSLDGVVKIWD 217 P ++ DG++K+WD Sbjct: 488 IGAVWHP-------HETSKVITCGWDGLIKLWD 513 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 67/185 (36%), Gaps = 19/185 (10%) Query: 131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA-ETGHCLKTLTYDKDWKRENGV 189 + S H++ V +V + +L S S D I++++ CL+T Sbjct: 215 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSK------- 267 Query: 190 VPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPE 249 + + F+ L + D +K+WD G + F + + NP+ Sbjct: 268 -AVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKV--------PYCVKFNPD 318 Query: 250 DGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDC 309 + L ++G + I W+ + ++Q D L ++ V S + + Sbjct: 319 EDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIV--FVDENRRFVSTSDDKSL 376 Query: 310 CLWRW 314 +W W Sbjct: 377 RVWEW 381 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 26/161 (16%), Positives = 63/161 (39%), Gaps = 6/161 (3%) Query: 13 GLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIAT 72 G T + + +F++ + ++ +++ + + + + SP+G+ +A Sbjct: 353 GAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLAC 412 Query: 73 ASDDFSVEII----HLSYGLLHTFIGH--TAPVISLTFNRKGNLLFTSSMDESIKIWDTL 126 S D + I F GH + F+ + + + + + IWD Sbjct: 413 QSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWK 472 Query: 127 NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 167 L AH + + +++S + + +DGLI+++D Sbjct: 473 TTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 68.2 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 25/124 (20%), Positives = 47/124 (37%), Gaps = 7/124 (5%) Query: 8 VGTQNGLKATCAKISPDGQFLAI-TQGLNILIYDINR--RTVSQTLVTSH--ARPFSELC 62 + + +SP+G++LA + ILI+ R + + H A ++ Sbjct: 390 IAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVD 449 Query: 63 WSPDGQCIATASDDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNL-LFTSSMDESI 120 +SPD + + + + I L+ F H I ++ + T D I Sbjct: 450 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLI 509 Query: 121 KIWD 124 K+WD Sbjct: 510 KLWD 513 >5OQL-d nrPDB Length = 446 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 55/238 (23%), Positives = 96/238 (40%), Gaps = 17/238 (7%) Query: 5 VTPVGT-QNGLKATCAKISPDGQFLAITQGLN-ILIYDINRRTVSQTLV-TSHARPFSEL 61 TP+ T Q G T A + G I I+D+ T Q + S +++ Sbjct: 144 TTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDV 203 Query: 62 CWSP-DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNL-LFTSSMDES 119 C++ + I + + D S+ + L + + FN + L +S D + Sbjct: 204 CFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHFACNRIVFNPMEAMNLAVASEDHN 263 Query: 120 IKIWDTLNG-SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLT 178 I I+D N + H AV+ V+ ++ SGSYD IR++ + GH Sbjct: 264 IYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELV-SGSYDRTIRLWRRDAGH------ 316 Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGC---VVRTFQVQPLE 233 +D + + + ++ +++Y+L S DG V++W V T Q Q LE Sbjct: 317 -SRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASERSGVKATRQRQALE 373 Score = 107 bits (266), Expect = 8e-24, Method: Composition-based stats. Identities = 58/317 (18%), Positives = 110/317 (34%), Gaps = 38/317 (11%) Query: 9 GTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQ 68 G G+ + C + + + + ++D+ R V +H L ++ D + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKK 123 Query: 69 CIATASDDFSVEIIH-----LSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 ++ A+D +++ + + T+ P SL+F+R N SS I+IW Sbjct: 124 LLSCATDG--IKLWDPYASPSNTTPIATWQE-GGPYTSLSFHRSANTFAASSGQGCIRIW 180 Query: 124 DTLNGSLMKTISAHS--EAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 181 D + + + I S + + V ++S++ S + D I +FD T + Sbjct: 181 DLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF 240 Query: 182 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 R V A L V S D + I+D Q H + Sbjct: 241 ACNRI--------VFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKG-------HVAA 285 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH-----CF 296 MD G ++SG + I W D +H+ + + Sbjct: 286 VMDVEFSPTGEE--LVSGSYDRTIRLWRRDAG------HSRDVYHTKRMQRVFRTMWTMD 337 Query: 297 GNIMCSLALNGDCCLWR 313 + + + +G+ LWR Sbjct: 338 SKYILTGSDDGNVRLWR 354 >6E29-D nrPDB Length = 345 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 63/342 (18%), Positives = 130/342 (38%), Gaps = 60/342 (17%) Query: 10 TQNGLKATCAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQ 68 T +TC + + G FLA + ++I+D+ V++ L H++ + L WS G+ Sbjct: 22 TIRSGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKL-RGHSKNITSLSWSRCGR 80 Query: 69 CIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSS--MDE-------- 118 + +A + V + L G + + APV + + F ++ D+ Sbjct: 81 YLLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITE 140 Query: 119 SIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSS-------------GSYDGLIRI 165 +++ L S+ K S ++ + D+ +++ G+ G + I Sbjct: 141 PVEVRYVL-PSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNI 199 Query: 166 FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW--------- 216 DA T + + + I+ ++ +E+ R LLV + D +++ + Sbjct: 200 IDARTREIIYS--------EKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAAD 251 Query: 217 ---DCIGGCVVRTFQ--VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 D I + FQ V L + S ++ + S Y N ++Y W Sbjct: 252 LDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEY---------VAASTYNNHELYIWERG 302 Query: 272 TKSLLQLLDGSLYHHSSPVMSIHCFGNIMCS-LALNGDCCLW 312 SL+++L+G V+ H ++ + G +W Sbjct: 303 HGSLVRMLEG--PKEEQGVIEWHPHRALLAACGLETGRINIW 342 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 31/88 (35%) Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLH 238 Y ++ + V+F+ +L +DG V IWD V R + L Sbjct: 15 YPENITNTIRSGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLS 74 Query: 239 HSCGMDFLNPEDGSTPLVISGYENGDIY 266 S +L +++ ++G Y Sbjct: 75 WSRCGRYLLSACQGWKVILWDLQDGKRY 102 Score = 40.9 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 24/158 (15%), Positives = 54/158 (34%), Gaps = 17/158 (10%) Query: 27 FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII---- 82 LA T + I D R + + + + + L + G+ + + D + Sbjct: 188 LLAGTTKGRLNIIDARTREIIYSEKIA-SGIITTLRLTESGRELLVNAQDRIIRTFIVPN 246 Query: 83 ------HLSYGLLHTFIGHTAPVISLTFNR-----KGNLLF-TSSMDESIKIWDTLNGSL 130 L V L++N G + ++ + + IW+ +GSL Sbjct: 247 LSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSL 306 Query: 131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 ++ + E ++ + + + + G G I I+ Sbjct: 307 VRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSV 344 >3JAP-g nrPDB Length = 326 Score = 141 bits (354), Expect = 5e-34, Method: Composition-based stats. Identities = 53/271 (19%), Positives = 104/271 (38%), Gaps = 22/271 (8%) Query: 46 VSQTLVTSHARPFSELCWSP-DGQCIATASDDFSVEIIHLSYGL------LHTFIGHTAP 98 V + + H + L S + + S D ++ L+ + ++ GH+ Sbjct: 9 VLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHI 68 Query: 99 VISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS 158 V + + GN ++S D+++++W+ G+ H+ V+SV + N S I+ S S Sbjct: 69 VQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKII-SAS 127 Query: 159 YDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK-FSENARY-LLVKSLDGVVKIW 216 D IR+++ G C L DW + V P + ++ R + +D +V+ W Sbjct: 128 RDKTIRVWNT-VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSW 186 Query: 217 DCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLL 276 +E + H+ ++ + P L S ++G IY WN KS Sbjct: 187 SLNEDS-------YRIEADFIGHNNYINVVQPS-PDGSLAASAGKDGQIYVWNLKHKSAF 238 Query: 277 QLLDGSLYHHSSPVMSIHCFGNIMCSLALNG 307 D ++ + + +G Sbjct: 239 MNFDAKD---EVFALAFSPSRFWLTAATASG 266 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 49/323 (15%), Positives = 104/323 (32%), Gaps = 67/323 (20%) Query: 8 VGTQNGLKATCAKISPD----GQFLAITQGLNILIYDI----NRRTVSQTLVTSHARPFS 59 GT G +S ++ ++ ++ + + + V H+ Sbjct: 11 RGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQ 70 Query: 60 ELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDE 118 ++ S DG +AS D ++ + +L+ G F+GHT V+S+ + + + ++S D+ Sbjct: 71 DVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDK 130 Query: 119 SIKIWDTLNGSLMKTISAHSEAVVSVDVPM---------NDSSILSSGSYDGLIRIFDAE 169 +I++W+T+ G + H++ V V V + S D ++R + Sbjct: 131 TIRVWNTV-GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLN 189 Query: 170 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW------------- 216 +Y + I+ V+ S + DG + +W Sbjct: 190 ED------SYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA 243 Query: 217 ---------------------------DCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPE 249 D ++ + + + Sbjct: 244 KDEVFALAFSPSRFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSA 303 Query: 250 DGSTPLVISGYENGDIYCWNSDT 272 DG T + +GY + I W T Sbjct: 304 DGQT--LFAGYTDNVIRVWQVMT 324 Score = 28.2 bits (61), Expect = 5.0, Method: Composition-based stats. Identities = 10/46 (21%), Positives = 22/46 (47%), Gaps = 3/46 (6%) Query: 271 DTKSLLQLLDGSLYHHSSPVMSIHCFG---NIMCSLALNGDCCLWR 313 + +++ +L G+L H+ V S+ N++ S + + WR Sbjct: 2 SSSNIMLVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWR 47 >5G04-R nrPDB Length = 499 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 105/303 (34%), Gaps = 63/303 (20%) Query: 57 PFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFT 113 + + WS G +A A D SV + S G + + P + S+ + ++GN L Sbjct: 186 YLNLVDWS-SGNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAV 243 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE-TGH 172 + +++WD ++ +++HS V S+ +S ILSSGS G I D H Sbjct: 244 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEH 300 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 232 + TL+ + ++++ + R+L D +V +W G PL Sbjct: 301 HVATLSGHS--------QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG----EGGWVPL 348 Query: 233 EKGVLHHSCGMDFLNPEDGSTPLVISGYE-NGDIYCWNSDTKSLLQLLDG---------- 281 + H S L G + I WN + + L +D Sbjct: 349 QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWS 408 Query: 282 -----------------------------SLYHHSSPVMSI--HCFGNIMCSLALNGDCC 310 L H+S V+S+ G + S A + Sbjct: 409 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 468 Query: 311 LWR 313 LWR Sbjct: 469 LWR 471 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 51/269 (18%), Positives = 101/269 (37%), Gaps = 29/269 (10%) Query: 11 QNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQC 69 Q G + +G +LA+ T + ++D+ ++ + + TSH+ L W+ Sbjct: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM-TSHSARVGSLSWNSYILS 282 Query: 70 IATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 + S + ++ + T GH+ V L + G L + D + +W + G Sbjct: 283 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 342 Query: 130 ----LMKTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTLTYDKDW 183 ++T + H AV +V S++L++ G+ D IRI++ +G CL + Sbjct: 343 GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ- 401 Query: 184 KRENGVVPISQVKFSENARYLLVKS--LDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 + + +S + + L+ + IW V + H S Sbjct: 402 --------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG--------HTSR 445 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNS 270 + DG+T V S + + W Sbjct: 446 VLSLTMSPDGAT--VASAAADETLRLWRC 472 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 47/126 (37%), Gaps = 14/126 (11%) Query: 182 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 D ++ V +S +L +LD V +W G +++ Q++ + + + Sbjct: 177 DAPEIRNDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW 234 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC 301 + G + ++ W+ + L+ + HS+ V S+ I+ Sbjct: 235 IK--------EGNYLAVGTSSAEVQLWDVQQQKRLRNM----TSHSARVGSLSWNSYILS 282 Query: 302 SLALNG 307 S + +G Sbjct: 283 SGSRSG 288 >6EOJ-D nrPDB Length = 470 Score = 138 bits (347), Expect = 3e-33, Method: Composition-based stats. Identities = 46/301 (15%), Positives = 101/301 (33%), Gaps = 59/301 (19%) Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIG-HTAPVISLTFNRKGNLLFT 113 + W+P+G+ + A+ + + S T + H + V ++ ++ + + + Sbjct: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 173 D IKIW + + +AH+E++ + NDS ++ S D +++I++ G Sbjct: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTC-SDDNILKIWNFSNGKQ 211 Query: 174 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 + L+ + + + S D +VK+WD G + + Sbjct: 212 ERVLSGHHWD--------VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI------ 257 Query: 234 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSL---------- 283 H+ P G+ + IS ++ ++ K L+ + D + Sbjct: 258 -LKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPIN 316 Query: 284 ------------------------------YHHSS--PVMSIHCFGNIMCSLALNGDCCL 311 Y H +S + G+I + A + Sbjct: 317 ESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 Query: 312 W 312 W Sbjct: 377 W 377 Score = 116 bits (290), Expect = 1e-26, Method: Composition-based stats. Identities = 49/254 (19%), Positives = 94/254 (37%), Gaps = 17/254 (6%) Query: 17 TCAKISPDGQF-LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 T K S D + ++ I I+ N ++ + + +H ++ +S + T SD Sbjct: 139 TTMKYSHDSDWMISGDADGMIKIWQPN-FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSD 197 Query: 76 DFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 134 D ++I + S G GH V S ++ + L+ ++S D +K+WD +G+ + +I Sbjct: 198 DNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI 257 Query: 135 SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ 194 V+ ++L + S D R+FD D+ PI++ Sbjct: 258 LKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINE 317 Query: 195 VKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTP 254 F+ L DG +K +D + + H C G Sbjct: 318 SMFT------LACY-DGSLKHFDLLQNLNEPILTIP-----YAHDKCITSLSYNPVG--H 363 Query: 255 LVISGYENGDIYCW 268 + + ++ I W Sbjct: 364 IFATAAKDRTIRFW 377 >3C9C-A nrPDB Length = 432 Score = 137 bits (345), Expect = 6e-33, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 92/238 (38%), Gaps = 28/238 (11%) Query: 51 VTSHARPFSELCWSPD-GQCIATASDDFSVEIIHLS--------YGLLHTFIGHTAPVIS 101 + H + L W+P+ + +ASDD ++ + ++ + F GHTA V Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 102 LTFNRKGNLLF-TSSMDESIKIWDTLNG---SLMKTISAHSEAVVSVDVPMNDSSILSSG 157 + ++ LF + + D+ + IWDT N T+ AH+ V + IL++G Sbjct: 239 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 298 Query: 158 SYDGLIRIFDAETGH-CLKTLTYDKDWKRENGVVPISQVKFSENARYLL-VKSLDGVVKI 215 S D + ++D L + KD I QV++S + +L D + + Sbjct: 299 SADKTVALWDLRNLKLKLHSFESHKD--------EIFQVQWSPHNETILASSGTDRRLHV 350 Query: 216 WDCIGGCVVRTFQ-----VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 WD ++ + L H+ + + ++ S E+ + W Sbjct: 351 WDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 Score = 120 bits (300), Expect = 8e-28, Method: Composition-based stats. Identities = 46/220 (20%), Positives = 89/220 (40%), Gaps = 22/220 (10%) Query: 19 AKISPD--GQFLAITQGLNILIYDIN------RRTVSQTLVTSHARPFSELCWS-PDGQC 69 +P+ G L+ + I ++DIN R ++ + T H ++ W Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 70 IATASDDFSVEIIHLSYGLL----HTFIGHTAPVISLTFNRKGNL-LFTSSMDESIKIWD 124 + +DD + I HT HTA V L+FN L T S D+++ +WD Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 125 TLNGSL-MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDW 183 N L + + +H + + V ++ +IL+S D + ++D ++ +D Sbjct: 309 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 368 Query: 184 KRE------NGVVPISQVKFSENARYLL-VKSLDGVVKIW 216 E IS ++ N +++ S D ++++W Sbjct: 369 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 Score = 104 bits (258), Expect = 7e-23, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 101/305 (33%), Gaps = 49/305 (16%) Query: 44 RTVSQTLVTSHARPFSELCWSPDGQC-IATASDDFSVEIIHL--------SYGLLH---T 91 + + +H + + P C IAT + V + G Sbjct: 119 GKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLR 178 Query: 92 FIGHTAPVISLTFNRKGN-LLFTSSMDESIKIWDT-LNGSLMK------TISAHSEAVVS 143 GH L++N N L ++S D +I +WD + + H+ V Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 144 VDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARY 203 V + S+ S + D + I+D + T + ++ + F+ + + Sbjct: 239 VAWHLLHESLFGSVADDQKLMIWDTRNNN-----TSKPSHTVDAHTAEVNCLSFNPYSEF 293 Query: 204 LL-VKSLDGVVKIWDCIGGCV-VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE 261 +L S D V +WD + + +F+ E + S + ++ S Sbjct: 294 ILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE---------TILASSGT 344 Query: 262 NGDIYCWNSDTKSLLQLLDGSLY----------HHSSPVMSIHCFGN---IMCSLALNGD 308 + ++ W+ Q + + H++ + N I+CS++ + Sbjct: 345 DRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNI 404 Query: 309 CCLWR 313 +W+ Sbjct: 405 MQVWQ 409 Score = 71.3 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 52/144 (36%), Gaps = 21/144 (14%) Query: 6 TPVGTQNGLKAT--CAKISPDGQFL--AITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 P T + A C +P +F+ + + ++D+ + SH ++ Sbjct: 270 KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQV 329 Query: 62 CWSPDGQ-CIATASDDFSVEIIHLSY---------------GLLHTFIGHTAPVISLTFN 105 WSP + +A++ D + + LS LL GHTA + ++N Sbjct: 330 QWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWN 389 Query: 106 RKGNLLF-TSSMDESIKIWDTLNG 128 + + S D +++W Sbjct: 390 PNEPWIICSVSEDNIMQVWQMAEN 413 >4GGA-A nrPDB Length = 420 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 105/303 (34%), Gaps = 63/303 (20%) Query: 57 PFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFT 113 + + WS G +A A D SV + S G + + P + S+ + ++GN L Sbjct: 107 YLNLVDWS-SGNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAV 164 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE-TGH 172 + +++WD ++ +++HS V S+ +S ILSSGS G I D H Sbjct: 165 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEH 221 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 232 + TL+ + ++++ + R+L D +V +W G PL Sbjct: 222 HVATLSGHS--------QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG----EGGWVPL 269 Query: 233 EKGVLHHSCGMDFLNPEDGSTPLVISGYE-NGDIYCWNSDTKSLLQLLDG---------- 281 + H S L G + I WN + + L +D Sbjct: 270 QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWS 329 Query: 282 -----------------------------SLYHHSSPVMSI--HCFGNIMCSLALNGDCC 310 L H+S V+S+ G + S A + Sbjct: 330 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 389 Query: 311 LWR 313 LWR Sbjct: 390 LWR 392 Score = 130 bits (326), Expect = 8e-31, Method: Composition-based stats. Identities = 51/269 (18%), Positives = 101/269 (37%), Gaps = 29/269 (10%) Query: 11 QNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQC 69 Q G + +G +LA+ T + ++D+ ++ + + TSH+ L W+ Sbjct: 145 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM-TSHSARVGSLSWNSYILS 203 Query: 70 IATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 + S + ++ + T GH+ V L + G L + D + +W + G Sbjct: 204 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 263 Query: 130 ----LMKTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTLTYDKDW 183 ++T + H AV +V S++L++ G+ D IRI++ +G CL + Sbjct: 264 GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ- 322 Query: 184 KRENGVVPISQVKFSENARYLLVKS--LDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 + + +S + + L+ + IW V + H S Sbjct: 323 --------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG--------HTSR 366 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNS 270 + DG+T V S + + W Sbjct: 367 VLSLTMSPDGAT--VASAAADETLRLWRC 393 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 47/126 (37%), Gaps = 14/126 (11%) Query: 182 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 D ++ V +S +L +LD V +W G +++ Q++ + + + Sbjct: 98 DAPEIRNDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW 155 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC 301 + G + ++ W+ + L+ + HS+ V S+ I+ Sbjct: 156 IK--------EGNYLAVGTSSAEVQLWDVQQQKRLRNM----TSHSARVGSLSWNSYILS 203 Query: 302 SLALNG 307 S + +G Sbjct: 204 SGSRSG 209 >4J0W-A nrPDB Length = 343 Score = 135 bits (340), Expect = 2e-32, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 113/320 (35%), Gaps = 36/320 (11%) Query: 14 LKATCAKISPD-GQFLAITQGLNILIYDINRRTVSQTLV----------TSHARPFSELC 62 L TC ++PD + + +I+ + + + H+ + Sbjct: 15 LSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMA 74 Query: 63 WSPDGQCIATASDDFSVEIIHLSY-GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIK 121 S DG+ +A+ + I L+TF GH V L F R + L+++S D S+K Sbjct: 75 ISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVK 134 Query: 122 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 181 +W+ S ++T+ H +AV ++D +++G DG +R++ L + Sbjct: 135 VWNVAENSYVETLFGHQDAVAALDALSR-ECCVTAGGRDGTVRVWKIPEESQL-VFYGHQ 192 Query: 182 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVV------RTFQVQPLEKG 235 ++ N +++ + DG V +W + + +P + Sbjct: 193 GSIDCIHLI---------NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQ 243 Query: 236 VLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTK-SLLQLLDGSLYHHSSPVMSIH 294 S LN T LV +G + + W L LL + Sbjct: 244 PFWISSVAALLN-----TDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFS 298 Query: 295 CFGNIMCSLALNGDCCLWRW 314 G+ + + L RW Sbjct: 299 SSGDFLVAGVGQEH-RLGRW 317 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 46/285 (16%), Positives = 100/285 (35%), Gaps = 42/285 (14%) Query: 50 LVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFI------------GHTA 97 ++ H + L +PD I +A+ D S+ + G I GH++ Sbjct: 9 VLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 68 Query: 98 PVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSG 157 V+ + + G L + + I IW+ + + T + H +AV + + L S Sbjct: 69 HVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF-RRGTHQLYST 127 Query: 158 SYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWD 217 S+D +++++ ++TL +D + + DG V++W Sbjct: 128 SHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECC--------VTAGGRDGTVRVWK 179 Query: 218 CIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQ 277 P E ++ + + ++SG ++G + W K L Sbjct: 180 I------------PEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLA 227 Query: 278 LLDGSLYHHSSPVM-------SIHC--FGNIMCSLALNGDCCLWR 313 L + P + S+ +++ + + + LW+ Sbjct: 228 LQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 272 Score = 103 bits (257), Expect = 9e-23, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 85/237 (35%), Gaps = 36/237 (15%) Query: 88 LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI-----------SA 136 + GH + L + +F+++ D SI W +G + I Sbjct: 6 DIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG 65 Query: 137 HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK 196 HS V+ + + D L+SG LI I++A++ L T T +D +S + Sbjct: 66 HSSHVLCMAISS-DGKYLASGDRSKLILIWEAQSCQHLYTFTGHRD--------AVSGLA 116 Query: 197 FSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLV 256 F L S D VK+W+ V T G +D L+ E V Sbjct: 117 FRRGTHQLYSTSHDRSVKVWNVAENSYVETL------FGHQDAVAALDALSRE----CCV 166 Query: 257 ISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH-CFGNIMCSLALNGDCCLW 312 +G +G + W +S L Y H + IH M S A +G LW Sbjct: 167 TAGGRDGTVRVWKIPEESQL-----VFYGHQGSIDCIHLINEEHMVSGADDGSVALW 218 >5LCW-Q nrPDB Length = 374 Score = 134 bits (337), Expect = 4e-32, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 105/303 (34%), Gaps = 63/303 (20%) Query: 57 PFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFT 113 + + WS G +A A D SV + S G + + P + S+ + ++GN L Sbjct: 61 YLNLVDWS-SGNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAV 118 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE-TGH 172 + +++WD ++ +++HS V S+ +S ILSSGS G I D H Sbjct: 119 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEH 175 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 232 + TL+ + ++++ + R+L D +V +W G PL Sbjct: 176 HVATLSGHS--------QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG----EGGWVPL 223 Query: 233 EKGVLHHSCGMDFLNPEDGSTPLVISGYE-NGDIYCWNSDTKSLLQLLDG---------- 281 + H S L G + I WN + + L +D Sbjct: 224 QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWS 283 Query: 282 -----------------------------SLYHHSSPVMSI--HCFGNIMCSLALNGDCC 310 L H+S V+S+ G + S A + Sbjct: 284 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 343 Query: 311 LWR 313 LWR Sbjct: 344 LWR 346 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 51/269 (18%), Positives = 101/269 (37%), Gaps = 29/269 (10%) Query: 11 QNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQC 69 Q G + +G +LA+ T + ++D+ ++ + + TSH+ L W+ Sbjct: 99 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM-TSHSARVGSLSWNSYILS 157 Query: 70 IATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 + S + ++ + T GH+ V L + G L + D + +W + G Sbjct: 158 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 217 Query: 130 ----LMKTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTLTYDKDW 183 ++T + H AV +V S++L++ G+ D IRI++ +G CL + Sbjct: 218 GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ- 276 Query: 184 KRENGVVPISQVKFSENARYLLVKS--LDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 + + +S + + L+ + IW V + H S Sbjct: 277 --------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG--------HTSR 320 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNS 270 + DG+T V S + + W Sbjct: 321 VLSLTMSPDGAT--VASAAADETLRLWRC 347 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 47/126 (37%), Gaps = 14/126 (11%) Query: 182 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 D ++ V +S +L +LD V +W G +++ Q++ + + + Sbjct: 52 DAPEIRNDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW 109 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC 301 + G + ++ W+ + L+ + HS+ V S+ I+ Sbjct: 110 IK--------EGNYLAVGTSSAEVQLWDVQQQKRLRNM----TSHSARVGSLSWNSYILS 157 Query: 302 SLALNG 307 S + +G Sbjct: 158 SGSRSG 163 >5Y1U-A nrPDB Length = 456 Score = 133 bits (335), Expect = 8e-32, Method: Composition-based stats. Identities = 51/267 (19%), Positives = 101/267 (37%), Gaps = 37/267 (13%) Query: 51 VTSHARPFSELCWSPD-GQCIATASDDFSVEIIHLSY--------GLLHTFIGHTAPVIS 101 + H + L W+P+ + +ASDD ++ + +S F GHTA V Sbjct: 204 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 102 LTFNRKGNLLF-TSSMDESIKIWDTLNG---SLMKTISAHSEAVVSVDVPMNDSSILSSG 157 ++++ LF + + D+ + IWDT + ++ AH+ V + IL++G Sbjct: 264 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 323 Query: 158 SYDGLIRIFDAETGH-CLKTLTYDKDWKRENGVVPISQVKFSENARYLL-VKSLDGVVKI 215 S D + ++D L + KD I QV++S + +L D + + Sbjct: 324 SADKTVALWDLRNLKLKLHSFESHKD--------EIFQVQWSPHNETILASSGTDRRLNV 375 Query: 216 WDCIGGCVVRTFQ-----VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 WD ++ + L H+ + + ++ S E+ + W Sbjct: 376 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW-- 433 Query: 271 DTKSLLQLLDGSLYHHSSPVMSIHCFG 297 + ++Y+ P S+ G Sbjct: 434 -------QMAENIYNDEDPEGSVDPEG 453 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 44/220 (20%), Positives = 88/220 (40%), Gaps = 22/220 (10%) Query: 19 AKISPD--GQFLAITQGLNILIYDINRRTVS------QTLVTSHARPFSELCWS-PDGQC 69 +P+ G L+ + I ++DI+ +T+ T H ++ W Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 273 Query: 70 IATASDDFSVEIIHLSYGLL----HTFIGHTAPVISLTFNRKGNL-LFTSSMDESIKIWD 124 + +DD + I H+ HTA V L+FN L T S D+++ +WD Sbjct: 274 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 333 Query: 125 TLNGSL-MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDW 183 N L + + +H + + V ++ +IL+S D + ++D ++ +D Sbjct: 334 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 393 Query: 184 KRE------NGVVPISQVKFSENARYLL-VKSLDGVVKIW 216 E IS ++ N +++ S D ++++W Sbjct: 394 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Score = 100 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 46/306 (15%), Positives = 103/306 (33%), Gaps = 49/306 (16%) Query: 43 RRTVSQTLVTSHARPFSELCWSPDGQCI-ATASDDFSVEIIHL--------SYGLLH--- 90 + + +H + + P CI AT + V + G + Sbjct: 143 SGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDL 202 Query: 91 TFIGHTAPVISLTFNRK-GNLLFTSSMDESIKIWDT----LNGSLM---KTISAHSEAVV 142 GH L++N L ++S D +I +WD G ++ + H+ V Sbjct: 203 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 262 Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR 202 V + S+ S + D + I+D + + T + ++ + F+ + Sbjct: 263 DVSWHLLHESLFGSVADDQKLMIWDTRSNN-----TSKPSHSVDAHTAEVNCLSFNPYSE 317 Query: 203 YLL-VKSLDGVVKIWDCIGGCV-VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY 260 ++L S D V +WD + + +F+ E + S + ++ S Sbjct: 318 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE---------TILASSG 368 Query: 261 ENGDIYCWNSDTKSLLQLLDGSLY----------HHSSPVMSIHCFGN---IMCSLALNG 307 + + W+ Q + + H++ + N ++CS++ + Sbjct: 369 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 428 Query: 308 DCCLWR 313 +W+ Sbjct: 429 IMQVWQ 434 Score = 69.8 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 48/130 (36%), Gaps = 19/130 (14%) Query: 18 CAKISPDGQFL--AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQ-CIATAS 74 C +P +F+ + + ++D+ + SH ++ WSP + +A++ Sbjct: 309 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 368 Query: 75 DDFSVEIIHLSY---------------GLLHTFIGHTAPVISLTFNRKGNLLF-TSSMDE 118 D + + LS LL GHTA + ++N + + S D Sbjct: 369 TDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 428 Query: 119 SIKIWDTLNG 128 +++W Sbjct: 429 IMQVWQMAEN 438 >6J6H-n nrPDB Length = 455 Score = 132 bits (333), Expect = 1e-31, Method: Composition-based stats. Identities = 55/269 (20%), Positives = 94/269 (34%), Gaps = 21/269 (7%) Query: 52 TSHARPFSELCWSP-DGQCIATASDDFSVEIIH--LSYGLLHTFIGHTAPVISLTFNRKG 108 H + L + P G I + +D +++I Y L F GH P+ +L F Sbjct: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC 218 Query: 109 NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 +SS D S+KIWDT G + + +S P N + S ++ D Sbjct: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 + + TYD + + I +K+ + + S D V+IW+ Sbjct: 279 VSENQGLVQTYD------HHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV------ 326 Query: 229 VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS---LLQLLDGSLYH 285 P+++ M FLN S + + IY ++ K ++ G Sbjct: 327 --PIKQISDTAQHSMPFLNVH-PSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSA 383 Query: 286 HSSPVMSIHCFGNIMCSLALNGDCCLWRW 314 ++ G +CS W W Sbjct: 384 GYGISLAFSGDGRYICSGDSKSRLFTWDW 412 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 43/220 (19%), Positives = 75/220 (34%), Gaps = 49/220 (22%) Query: 129 SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG-HCLKTLTYDKDWKREN 187 +++ H E ++ ++ SG D I+I+D CL+ Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNK----- 207 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCV------------------------ 223 PI ++F+E+ + L S D VKIWD G V Sbjct: 208 ---PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 Query: 224 ------------VRTFQVQPLEKGVLHHSCGMDFLNP-EDGSTPLVISGYENGDIYCWNS 270 R + Q L + HH + L DGS IS E+ + W + Sbjct: 265 VGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSK--FISSSEDKTVRIWEN 322 Query: 271 DTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 ++ + + HS P +++H N C+ +++ Sbjct: 323 QINVPIKQISDT-AQHSMPFLNVHPSQNYFCAQSMDNRIY 361 Score = 97.5 bits (241), Expect = 6e-21, Method: Composition-based stats. Identities = 48/257 (18%), Positives = 95/257 (36%), Gaps = 17/257 (6%) Query: 27 FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY 86 L+ I I+D H +P L ++ D Q ++S D SV+I Sbjct: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 Query: 87 GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD----TLNGSLMKTISAHSEAVV 142 G + T + + + F + S + + N L++T H +++ Sbjct: 238 GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSIL 297 Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR 202 ++ + S +SS S D +RI++ + +K ++ +P V S+N Sbjct: 298 ALKYFPDGSKFISS-SEDKTVRIWENQINVPIKQIS-----DTAQHSMPFLNVHPSQN-- 349 Query: 203 YLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN 262 Y +S+D + + + ++ P + H S G G + SG Sbjct: 350 YFCAQSMDNRIYSF-----SLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSK 404 Query: 263 GDIYCWNSDTKSLLQLL 279 ++ W+ +T LL + Sbjct: 405 SRLFTWDWNTSRLLNNI 421 Score = 57.1 bits (136), Expect = 9e-09, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 53/149 (35%), Gaps = 9/149 (6%) Query: 19 AKISPDG-QFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 K PDG +F++ ++ + I++ + + + L P S D Sbjct: 299 LKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDN 358 Query: 78 SVEIIHLSYGLLH----TFIGHTAPVI--SLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 131 + L F GH++ SL F+ G + + + WD L+ Sbjct: 359 RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLL 418 Query: 132 KTISAH-SEAVVSVDVPMND-SSILSSGS 158 I ++ + VD + S ++ SG+ Sbjct: 419 NNIKIPGNKPITQVDWHPQETSKVICSGA 447 Score = 40.9 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 15/92 (16%), Positives = 31/92 (33%), Gaps = 7/92 (7%) Query: 224 VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDT-KSLLQLLDGS 282 R + + + + H G L + L++SG + I W+ L+ G Sbjct: 146 FRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG- 204 Query: 283 LYHHSSPV--MSIHCFGNIMCSLALNGDCCLW 312 H+ P+ + S + + +W Sbjct: 205 ---HNKPIKALRFTEDCQSFLSSSFDRSVKIW 233 >5OQL-J nrPDB Length = 912 Score = 132 bits (333), Expect = 1e-31, Method: Composition-based stats. Identities = 67/335 (20%), Positives = 117/335 (34%), Gaps = 51/335 (15%) Query: 18 CAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 + + LA T G N ++ ++N + P S L +P G + S Sbjct: 25 SVALENGARILASTLGENAILTELNTGKRLAEIQ-GDGEPISTLTITPSGSHLIVCSRSL 83 Query: 78 SVEIIHLSYG---------LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 ++ I L+ L+ T H PV+ L +R LL T + D +IKIWD + G Sbjct: 84 TMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGG 143 Query: 129 SLMKTISAHSEAVVSVDV---------------PMNDSS--------------ILSSGSY 159 + T+S S V ++ P S L+ G+ Sbjct: 144 YVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQ 203 Query: 160 DGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI 219 DG IRIFD + D K+E + + +S LL S D + +W Sbjct: 204 DGRIRIFDL-YKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWR 262 Query: 220 GGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLL 279 G +Q P+ + L S G + S +G + W++ T + Sbjct: 263 DG----IWQGTPMLRHELLESVGFL------NEGKWMYSAGTSGVLRIWDTTTHHEITKK 312 Query: 280 DGSLYHHSSPVMSIH-CFGNIMCSLALNGDCCLWR 313 + + + ++ +++ + L+R Sbjct: 313 QDAKSEGEAILSAVSLPERSLILCAQADFTLVLYR 347 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 56/322 (17%), Positives = 108/322 (33%), Gaps = 61/322 (18%) Query: 45 TVSQTLVTSHARPFSELCWS-PDGQCIATASDDFSVEIIHLSYGLLHT------------ 91 + + +H +L + PD +A A++ + I+ + ++ Sbjct: 364 EPFRRISGTH-DEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYF 422 Query: 92 ------FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL----NGSLMKTISAHSEAV 141 GH V+SL + G+ + + S D + ++W + + + H E+V Sbjct: 423 GHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESV 482 Query: 142 VSVDVPM---------------NDSSILSSGSYDGLIRIFDA-ETGHCLKTLTYDKDWKR 185 +V +P + + L SGS D ++ D LT +R Sbjct: 483 GAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLT--SSLRR 540 Query: 186 ENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD- 244 I+ + S N + S D VKIWD V + + + Sbjct: 541 LAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTP 600 Query: 245 FLNPEDGSTP---LVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI-----HCF 296 + E GS +V++G + I WN + ++ +G HS V+ + Sbjct: 601 VIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEG----HSHNVLKVVWLHISRD 656 Query: 297 GNI------MCSLALNGDCCLW 312 +I S + +W Sbjct: 657 DSITKTKVQFASAGADTLVKVW 678 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 47/309 (15%), Positives = 96/309 (31%), Gaps = 54/309 (17%) Query: 4 FVTPVGTQNGLKATCAKISPD--GQFLAITQ-GLNILIYDINRRTVSQT---LVTSHARP 57 F V G + + D G ++A ++ ++ S T + T H Sbjct: 422 FGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLES 481 Query: 58 FSELCW-------------SPDGQ---CIATASDDFSVEIIHLSYGLLH--------TFI 93 + +P + + S D V+ + L + Sbjct: 482 VGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRL 541 Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 H + +L + G L ++S D+++KIWD + + H V +V ++ + Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPV 601 Query: 154 L-------------SSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ-VKFSE 199 + +GS D I++++ C++T + + IS+ ++ Sbjct: 602 IQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITK 661 Query: 200 NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 259 D +VK+WD G T L T ++ S Sbjct: 662 TKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHS----------KTNILASA 711 Query: 260 YENGDIYCW 268 + + W Sbjct: 712 GSDSKVTFW 720 Score = 91.4 bits (225), Expect = 4e-19, Method: Composition-based stats. Identities = 39/349 (11%), Positives = 101/349 (28%), Gaps = 42/349 (12%) Query: 5 VTPVGTQNGLKATCAKISPDG-QFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCW 63 + C SP+ L+ ++ + ++ T + H + + Sbjct: 224 PKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHEL-LESVGF 282 Query: 64 SPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTA----PVISLTFNRKGNLLFTSSMDES 119 +G+ + +A + I + T ++S + +L+ + D + Sbjct: 283 LNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFT 342 Query: 120 IKIWDTLNG------------SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRI-- 165 + ++ + + IS + ++ + + D S+++ + IRI Sbjct: 343 LVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVS 402 Query: 166 ------FDAETGHCLK-TLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDC 218 + + C + + + + + ++ S D ++W Sbjct: 403 VKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRV 462 Query: 219 ----IGGCVVRTFQVQPLEKGVLH------HSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 F G + + F NP D +ISG ++ + Sbjct: 463 DPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKR 522 Query: 269 NS-----DTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + L L + + I G + S + + +W Sbjct: 523 DIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIW 571 Score = 87.9 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 62/370 (16%), Positives = 110/370 (29%), Gaps = 70/370 (18%) Query: 5 VTPVGTQNGL--KATCAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSEL 61 T V T + LA I I+DI V+ T V+ + S L Sbjct: 101 PTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHT-VSGPSVLVSAL 159 Query: 62 CW------------------------SPDGQCIAT------ASDDFSVEIIHLSYGL--- 88 + + D IA+ + D + I L Sbjct: 160 HFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTP 219 Query: 89 -----LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVS 143 H + V + ++ + + L + S D+++ +W +G T E + S Sbjct: 220 VYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLES 279 Query: 144 VDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARY 203 V +N+ + S G++RI+D T H + K + G +S V Sbjct: 280 VGF-LNEGKWMYSAGTSGVLRIWDTTTHHEI----TKKQDAKSEGEAILSAVSL-PERSL 333 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEK-----GVLHHSCGMDFLNPEDGSTPLVIS 258 +L D + ++ V + L + H D S + + Sbjct: 334 ILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIAT 393 Query: 259 GYENGDIYCWNSDTKSLLQLLDGS-------------LYHHSSPVMSIHCF--GNIMCSL 303 E+ I + + L H VMS+ G+ + S Sbjct: 394 NSED--IRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASG 451 Query: 304 ALNGDCCLWR 313 + + LWR Sbjct: 452 SKDNTARLWR 461 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 35/233 (15%), Positives = 77/233 (33%), Gaps = 26/233 (11%) Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 G + S++ E+ + + G + I E + ++ + + S ++ S +RI+ Sbjct: 30 NGARILASTLGENAILTELNTGKRLAEIQGDGEPISTLTITPSGSHLIVC-SRSLTMRIY 88 Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 ++ + P+ + + L + DG +KIWD IGG V T Sbjct: 89 SLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHT 148 Query: 227 FQVQPLEKGVLHH-------SCGMDFLNPEDGSTP-------------LVISGYENGDIY 266 + LH P+ GS + G ++G I Sbjct: 149 VSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIR 208 Query: 267 CWNSDTKSLLQL-----LDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWRW 314 ++ ++ + + + ++ + + S + + LW W Sbjct: 209 IFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLW 261 >5WYK-BB nrPDB Length = 943 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 42/218 (19%), Positives = 90/218 (41%), Gaps = 26/218 (11%) Query: 17 TCAKISPDG-QFLAITQGLNILIYDIN---------RRTVSQTLVTSH------ARPFSE 60 ++ DG + + + + +D + L H Sbjct: 477 WSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILC 536 Query: 61 LCWSPDGQCIATASDDFSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDES 119 + SPD + +A + D +V++ L S + GH PV+S+ + ++ TSS D++ Sbjct: 537 VRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKN 596 Query: 120 IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY 179 IKIW G K++ AH +++++V + S S D +++ +D E C++ L Sbjct: 597 IKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSC-SKDAVVKYWDGEKFECIQKLYA 655 Query: 180 DKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWD 217 + + + + + +++ S D ++IW+ Sbjct: 656 HQ--------SEVWALAVATDGGFVVSSSHDHSIRIWE 685 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 53/318 (16%), Positives = 111/318 (34%), Gaps = 46/318 (14%) Query: 15 KATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 74 IS D + LA ++ I++I +T +A + P G + + Sbjct: 393 DVRSIDISDDNKLLATASNGSLKIWNIKTHKCIRTFECGYA---LTCKFLPGGLLVILGT 449 Query: 75 DDFSVEIIHLSYGLL--HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL------ 126 + +++ L+ L H A + SL G L T S D+++K WD Sbjct: 450 RNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLV 509 Query: 127 ---NGSLMKTISAH-------SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKT 176 + + H ++ ++ V V +D + S D +++F ++ + Sbjct: 510 PGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISL-LDNTVKVFFLDSMKFYLS 568 Query: 177 LTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGV 236 L K +P+ + S +++ ++ S D +KIW G ++ Sbjct: 569 LYGHK--------LPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMN 620 Query: 237 LHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPV--MSIH 294 + S ++ + W+ + +Q L Y H S V +++ Sbjct: 621 VKFLPQSHNF----------FSCSKDAVVKYWDGEKFECIQKL----YAHQSEVWALAVA 666 Query: 295 CFGNIMCSLALNGDCCLW 312 G + S + + +W Sbjct: 667 TDGGFVVSSSHDHSIRIW 684 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 57/275 (20%), Positives = 101/275 (36%), Gaps = 38/275 (13%) Query: 13 GLKATCAKISPDGQF-LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIA 71 G TC K P G + T+ + ++D+ ++ T+ +H L + DG+ + Sbjct: 431 GYALTC-KFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLV 489 Query: 72 TASDDFSVEIIHLS----------YGLLHTFIGH-------TAPVISLTFNRKGNLLFTS 114 T S D +V+ L H T ++ + + L S Sbjct: 490 TGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAIS 549 Query: 115 SMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCL 174 +D ++K++ + ++ H V+S+D+ + I++S S D I+I+ + G C Sbjct: 550 LLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITS-SADKNIKIWGLDFGDCH 608 Query: 175 KTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEK 234 K+L +D I VKF + S D VVK WD ++ E Sbjct: 609 KSLFAHQD--------SIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEV 660 Query: 235 GVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN 269 L + F V+S + I W Sbjct: 661 WALAVATDGGF----------VVSSSHDHSIRIWE 685 Score = 104 bits (258), Expect = 7e-23, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 87/253 (34%), Gaps = 27/253 (10%) Query: 28 LAITQGLNILIYDINRRTVSQTLVTS-----------HARPFSELCWSPDGQCIATASDD 76 L + ++ I+DI + L + L D +A D Sbjct: 41 LITSALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYAD 100 Query: 77 FSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 +++ L S +L F GH A + L F+ G L + S D +I +WD + + + Sbjct: 101 GVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLR 160 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 +H +++ L S S DG+I+++D +T C++T V Sbjct: 161 SHKDSITG--FWCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAV------ 212 Query: 196 KFSENARYLLVKSLDGVVKIW--DCIGGCVVRTF-QVQPLEKGVLHHSCGMDFLNPEDGS 252 L+ D VKIW D + ++ EK ++F+ Sbjct: 213 ----KDDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDK 268 Query: 253 TPLVISGYENGDI 265 T + I Sbjct: 269 TSFFYIQNADKTI 281 Score = 90.2 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 38/217 (17%), Positives = 78/217 (35%), Gaps = 36/217 (16%) Query: 108 GNLLFTSSMDESIKIWDTLNGSLMKTIS-----------AHSEAVVSVDVPMNDSSILSS 156 G L+ ++ D + IWD G L+ +S A + D+ +L+ Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 157 GSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW 216 G DG+I+++D + L K I+ ++F L+ S D + +W Sbjct: 97 GYADGVIKVWDLMSKTVLLNFNGHK--------AAITLLQFDGTGTRLISGSKDSNIIVW 148 Query: 217 DCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLL 276 D +G + + S + ED +IS ++G I W+ T + Sbjct: 149 DLVGEVGLYKLRSHK-------DSITGFWCQGED----WLISTSKDGMIKLWDLKTHQCI 197 Query: 277 QLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWR 313 + H+ + +++ + + +W+ Sbjct: 198 ----ETHIAHTGECWGLAVKDDLLITTGTDSQVKIWK 230 >5OV3-A nrPDB Length = 381 Score = 132 bits (331), Expect = 2e-31, Method: Composition-based stats. Identities = 51/302 (16%), Positives = 123/302 (40%), Gaps = 16/302 (5%) Query: 18 CAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 + G LA+ I+I+D R +++ ++++H P LCWS DG + +AS D Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAK-IISAHIHPVCSLCWSRDGHKLVSASTD 88 Query: 77 FSVEIIHLSYGLLHTFIGHTAPVISLTFNR--KGNLLFTSSMDESIKIWDTLNGSLMKTI 134 V + G +P++ + ++ + +L + + TL+ S + Sbjct: 89 NIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVML--TLSDSKHVVL 146 Query: 135 SAHSEAVVSVDVPMN-DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 193 ++ ++V + + +G+ G I + ++ + + + I Sbjct: 147 PVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTG---TSNTTAIK 203 Query: 194 QVKFSENARYLLVKSLDGVVKIWDCIG-GCVVRTFQVQPLEK--GVLHHSCGMDFLNPED 250 ++F+ L+ + D +++++D R + +P++K +++ + D Sbjct: 204 SIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGD 263 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 G + S ++ +Y W +L+++L G+ V + H I+ S++ G Sbjct: 264 GEYIVAGSARQHA-LYIWEKSIGNLVKILHGTRGELLLDV-AWHPVRPIIASISS-GVVS 320 Query: 311 LW 312 +W Sbjct: 321 IW 322 Score = 38.2 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 31/87 (35%), Gaps = 6/87 (6%) Query: 228 QVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHS 287 Q P E M + L+ G +G I W+ T+ + +++ H Sbjct: 12 QNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIIS----AHI 67 Query: 288 SPVMSI--HCFGNIMCSLALNGDCCLW 312 PV S+ G+ + S + + W Sbjct: 68 HPVCSLCWSRDGHKLVSASTDNIVSQW 94 >4U1E-I nrPDB Length = 347 Score = 130 bits (326), Expect = 9e-31, Method: Composition-based stats. Identities = 49/225 (21%), Positives = 93/225 (41%), Gaps = 19/225 (8%) Query: 92 FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS 151 GH P+ + +N++G+LLF+ S D S +W +LNG + T+ H+ + S+DV + Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCF-T 64 Query: 152 SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLD- 210 +GS D I+++D G C+ T WK VP+ +V+FS Y L + Sbjct: 65 KYCVTGSADYSIKLWDVSNGQCVAT------WKSP---VPVKRVEFSPCGNYFLAILDNV 115 Query: 211 ----GVVKIWDCIGGCVVRTF---QVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENG 263 G + I++ +P+ K + H + +I+G+++G Sbjct: 116 MKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDG 175 Query: 264 DIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGD 308 I ++ + L+ S M + + + + Sbjct: 176 KISKYDVSNNY-EYVDSIDLHEKSISDMQFSPDLTYFITSSRDTN 219 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 94/253 (37%), Gaps = 24/253 (9%) Query: 50 LVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKG 108 +T H RP +++ ++ +G + + S D S + + G L T GHT + S+ + Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFT 64 Query: 109 NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYD------GL 162 T S D SIK+WD NG + T + V V+ + L+ D G Sbjct: 65 KYCVTGSADYSIKLWDVSNGQCVATWKSPV-PVKRVEFSPCGNYFLAI--LDNVMKNPGS 121 Query: 163 IRIFDAETGHCLKTLT-----YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWD 217 I I++ E LT G+ + +S +Y++ DG + +D Sbjct: 122 INIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYD 181 Query: 218 CIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQ 277 + ++ LH D D I+ + + + + T +L+ Sbjct: 182 VSNN-------YEYVDSIDLHEKSISDMQFSPD--LTYFITSSRDTNSFLVDVSTLQVLK 232 Query: 278 LLDGSLYHHSSPV 290 + +++ + Sbjct: 233 KYETDCPLNTAVI 245 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 39/251 (15%), Positives = 78/251 (31%), Gaps = 24/251 (9%) Query: 12 NGLKATCAKISPDGQFLAITQGL------NILIYDINRRTVSQTLVTSHARPFSELC--- 62 + + + SP G + +I IY+I R + + L P ++ Sbjct: 92 SPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHE 151 Query: 63 ---------WSPDGQCIATASDDFSVEIIHLS--YGLLHTFIGHTAPVISLTFNRKGNLL 111 WS G+ I D + +S Y + + H + + F+ Sbjct: 152 GLDAATVAGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYF 211 Query: 112 FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 171 TSS D + + D ++K +V P+ + IL G + A G Sbjct: 212 ITSSRDTNSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEG 271 Query: 172 HCLKTLTY----DKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 + ++ + + P++ V S DG +++ + Sbjct: 272 KFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEKSYFDFKY 331 Query: 228 QVQPLEKGVLH 238 V+ + H Sbjct: 332 DVEKAAEAKEH 342 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 19/122 (15%), Positives = 35/122 (28%), Gaps = 13/122 (10%) Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS 240 K K P++QVK+++ L S D +W + G + T + Sbjct: 2 KAIKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVD 61 Query: 241 CGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIM 300 C T ++G + I W+ + + GN Sbjct: 62 C----------FTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVE---FSPCGNYF 108 Query: 301 CS 302 + Sbjct: 109 LA 110 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 32/178 (17%), Positives = 66/178 (37%), Gaps = 17/178 (9%) Query: 5 VTPVGTQNGLKA-TCAKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPFSELC 62 + + T GL A T A S G+++ A + I YD++ + H + S++ Sbjct: 144 IHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQ 203 Query: 63 WSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSS----MDE 118 +SPD T+S D + ++ +S + P+ + + D Sbjct: 204 FSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDV 263 Query: 119 S----------IKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 + + + + + + H + +V + +S +SG DG IR+ Sbjct: 264 TTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSY-ASGGEDGFIRLH 320 >3CFV-B nrPDB Length = 414 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 47/238 (19%), Positives = 89/238 (37%), Gaps = 28/238 (11%) Query: 51 VTSHARPFSELCWSPD-GQCIATASDDFSVEIIHLSYG--------LLHTFIGHTAPVIS 101 + H + L W+ + + +ASDD +V + ++ G F GH+A V Sbjct: 175 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 234 Query: 102 LTFNRKGNLLF-TSSMDESIKIWDTLNG---SLMKTISAHSEAVVSVDVPMNDSSILSSG 157 + ++ LF + + D+ + IWDT + + AH+ V + IL++G Sbjct: 235 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 294 Query: 158 SYDGLIRIFDAETGH-CLKTLTYDKDWKRENGVVPISQVKFSENARYLL-VKSLDGVVKI 215 S D + ++D L T KD I QV +S + +L D + + Sbjct: 295 SADKTVALWDLRNLKLKLHTFESHKD--------EIFQVHWSPHNETILASSGTDRRLNV 346 Query: 216 WDCIGGCVVRTFQ-----VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 WD ++ + L H+ + + ++ S E+ + W Sbjct: 347 WDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Score = 115 bits (288), Expect = 2e-26, Method: Composition-based stats. Identities = 44/213 (20%), Positives = 84/213 (39%), Gaps = 20/213 (9%) Query: 24 DGQFLAITQGLNILIYDINRRTVS------QTLVTSHARPFSELCWS-PDGQCIATASDD 76 G L+ + + ++DIN + + T H+ ++ W + +DD Sbjct: 192 SGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADD 251 Query: 77 FSVEIIHLSYGLL----HTFIGHTAPVISLTFNRKGNL-LFTSSMDESIKIWDTLNGSL- 130 + I H HTA V L+FN L T S D+++ +WD N L Sbjct: 252 QKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLK 311 Query: 131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE---- 186 + T +H + + V ++ +IL+S D + ++D ++ +D E Sbjct: 312 LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFI 371 Query: 187 --NGVVPISQVKFSENARYLL-VKSLDGVVKIW 216 IS ++ N +++ S D +++IW Sbjct: 372 HGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Score = 93.3 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 33/170 (19%), Positives = 66/170 (38%), Gaps = 22/170 (12%) Query: 19 AKIS--PDGQFLAITQGLNILIYDINRRTVSQT--LVTSHARPFSELCWSPDGQC-IATA 73 + F ++ ++I+D T S+ LV +H + L ++P + +AT Sbjct: 235 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 294 Query: 74 SDDFSVEIIHLSY--GLLHTFIGHTAPVISLTFNR-KGNLLFTSSMDESIKIWDTLN--- 127 S D +V + L LHTF H + + ++ +L +S D + +WD Sbjct: 295 SADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGE 354 Query: 128 -----------GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 L+ H+ + N+ ++ S S D +++I+ Sbjct: 355 EQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 24/146 (16%), Positives = 52/146 (35%), Gaps = 19/146 (13%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQFL--AITQGLNILIYDINRRTVSQTLVTSHARPFS 59 + + + + C +P +F+ + + ++D+ + SH Sbjct: 264 TSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIF 323 Query: 60 ELCWSPDGQ-CIATASDDFSVEIIHLSY---------------GLLHTFIGHTAPVISLT 103 ++ WSP + +A++ D + + LS LL GHTA + + Sbjct: 324 QVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFS 383 Query: 104 FNRKGNLLF-TSSMDESIKIWDTLNG 128 +N + + S D ++IW Sbjct: 384 WNPNEPWVICSVSEDNIMQIWQMAEN 409 Score = 67.9 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 30/184 (16%), Positives = 60/184 (32%), Gaps = 14/184 (7%) Query: 133 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 + H + + N S L S S D + ++D G + D + Sbjct: 174 RLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIV-DAKAIFTGHSAVV 232 Query: 193 SQVKFS-ENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG 251 V + + + D + IWD T + L V H+ ++ L+ Sbjct: 233 EDVAWHLLHESLFGSVADDQKLMIWDTRSNT---TSKPSHL---VDAHTAEVNCLSFNPY 286 Query: 252 STPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF---GNIMCSLALNGD 308 S ++ +G + + W+ L+L + H + +H I+ S + Sbjct: 287 SEFILATGSADKTVALWDL---RNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRR 343 Query: 309 CCLW 312 +W Sbjct: 344 LNVW 347 >4N14-A nrPDB Length = 314 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 105/303 (34%), Gaps = 63/303 (20%) Query: 57 PFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFT 113 + + WS G +A A D SV + S G + + P + S+ + ++GN L Sbjct: 23 YLNLVDWS-SGNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAV 80 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE-TGH 172 + +++WD ++ +++HS V S+ +S ILSSGS G I D H Sbjct: 81 GTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDVRVAEH 137 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 232 + TL+ + ++++ + R+L D +V +W G PL Sbjct: 138 HVATLSGHS--------QEVCGLRWAPDGRHLASGGNDNLVNVWPSAPG----EGGWVPL 185 Query: 233 EKGVLHHSCGMDFLNPEDGSTPLVISGYE-NGDIYCWNSDTKSLLQLLDG---------- 281 + H S L G + I WN + + L +D Sbjct: 186 QTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWS 245 Query: 282 -----------------------------SLYHHSSPVMSI--HCFGNIMCSLALNGDCC 310 L H+S V+S+ G + S A + Sbjct: 246 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 305 Query: 311 LWR 313 LWR Sbjct: 306 LWR 308 Score = 124 bits (310), Expect = 6e-29, Method: Composition-based stats. Identities = 51/269 (18%), Positives = 101/269 (37%), Gaps = 29/269 (10%) Query: 11 QNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQC 69 Q G + +G +LA+ T + ++D+ ++ + + TSH+ L W+ Sbjct: 61 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM-TSHSARVGSLSWNSYILS 119 Query: 70 IATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 + S + ++ + T GH+ V L + G L + D + +W + G Sbjct: 120 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGE 179 Query: 130 ----LMKTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTLTYDKDW 183 ++T + H AV +V S++L++ G+ D IRI++ +G CL + Sbjct: 180 GGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ- 238 Query: 184 KRENGVVPISQVKFSENARYLLVKS--LDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 + + +S + + L+ + IW V + H S Sbjct: 239 --------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKG--------HTSR 282 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNS 270 + DG+T V S + + W Sbjct: 283 VLSLTMSPDGAT--VASAAADETLRLWRC 309 Score = 37.8 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 47/126 (37%), Gaps = 14/126 (11%) Query: 182 DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC 241 D ++ V +S +L +LD V +W G +++ Q++ + + + Sbjct: 14 DAPEIRNDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAW 71 Query: 242 GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMC 301 + G + ++ W+ + L+ + HS+ V S+ I+ Sbjct: 72 IK--------EGNYLAVGTSSAEVQLWDVQQQKRLRNM----TSHSARVGSLSWNSYILS 119 Query: 302 SLALNG 307 S + +G Sbjct: 120 SGSRSG 125 >5L9T-R nrPDB Length = 493 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 104/294 (35%), Gaps = 29/294 (9%) Query: 26 QFLAITQGLNILIYDINRRTVSQTLVTSHARP-FSELCWSPDGQCIATASDDFSVEIIHL 84 L++ G + ++ V++ S + + WS G +A + V+I Sbjct: 199 NVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDA 258 Query: 85 SYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG--SLMKTISAHSEAV 141 + G L GHTA V +L +N + L + S D I D + + H + V Sbjct: 259 AAGKKLSMLEGHTARVGALAWNAE--QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEV 316 Query: 142 VSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA 201 + D +L+SG D + +++ + ++ T + + + +S + Sbjct: 317 CGLKWST-DHQLLASGGNDNKLLVWNHSSLSPVQQYTEH--------LAAVKAIAWSPHQ 367 Query: 202 RYLLV---KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS 258 LL + D ++ W+ + G ++ + + ++ Sbjct: 368 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTH--------- 418 Query: 259 GYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 GY I W + + + L G + + +++ G + + A + W Sbjct: 419 GYSQNQILVWKYPSLTQVAKLTG--HSYRVLYLAMSPDGEAIVTGAGDETLRFW 470 Score = 118 bits (295), Expect = 4e-27, Method: Composition-based stats. Identities = 47/271 (17%), Positives = 96/271 (35%), Gaps = 30/271 (11%) Query: 12 NGLKATCAKISPDGQFLAITQGLN-ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI 70 G T S G +A+ + I+D +++ H L W + + + Sbjct: 228 EGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKL-SMLEGHTARVGALAW--NAEQL 284 Query: 71 ATASDDFSVEIIHLSYGLL---HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 ++ S D + + L GH V L ++ LL + D + +W+ + Sbjct: 285 SSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSS 344 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTLTYDKDWKR 185 S ++ + H AV ++ + +L+S G+ D IR ++ TG L+ + Sbjct: 345 LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQ--- 401 Query: 186 ENGVVPISQVKFSENARYLLV--KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGM 243 + + +S++A L+ + +W V L S Sbjct: 402 ------VCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSP-- 453 Query: 244 DFLNPEDGSTPLVISGYENGDIYCWNSDTKS 274 DG +++G + + WN +K+ Sbjct: 454 ------DGEA--IVTGAGDETLRFWNVFSKT 476 >4BTS-AR nrPDB Length = 343 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 53/287 (18%), Positives = 105/287 (36%), Gaps = 34/287 (11%) Query: 40 DINRRTVSQTLVTSHARPFSELC--WSP----DGQCIATASDDFSVEIIHLS-------Y 86 ++ + V + ++ H+ + + +S D + + S D +V I L + Sbjct: 6 SLDIQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYF 65 Query: 87 GLLHT-FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVD 145 G+ H GH V L +++ +SS D+++++WD G+ K H V SV Sbjct: 66 GIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVA 125 Query: 146 VPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY---DKDWKRENGVVPI--SQVKFSEN 200 ++ ILS+G+ I++++ G C + DW PI S K Sbjct: 126 FSPDNRQILSAGAE-REIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPF 183 Query: 201 ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY 260 A Y DG +K+W+ + + E V H S + + +G Sbjct: 184 APYFASVGWDGRLKVWNTNFQIR---YTFKAHESNVNHLSIS--------PNGKYIATGG 232 Query: 261 ENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNG 307 ++ + W+ +L + ++ + + G Sbjct: 233 KDKKLLIWDIL--NLTYPQREFDAGSTINQIAFNPKLQWVAVGTDQG 277 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 47/309 (15%), Positives = 105/309 (33%), Gaps = 51/309 (16%) Query: 4 FVTPVGTQNGLKATCAKI--------SPDGQFL-AITQGLNILIYDINRRT------VSQ 48 V G G I + D L + ++ ++I+ + + Sbjct: 10 QVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPH 69 Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRK 107 +T H S+L S + ++S D ++ + L G F+GH + V S+ F+ Sbjct: 70 KALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPD 129 Query: 108 GNLLFTSSMDESIKIWDTLNGSLMKT---ISAHSEAVVSVDVPM---------NDSSILS 155 + ++ + IK+W+ L G + HS+ V V + + Sbjct: 130 NRQILSAGAEREIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFA 188 Query: 156 SGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 S +DG +++++ T + ++ + S N +Y+ D + I Sbjct: 189 SVGWDGRLKVWNT-NFQIRYTFKAHE--------SNVNHLSISPNGKYIATGGKDKKLLI 239 Query: 216 WDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN--SDTK 273 WD + P + + NP ++ + + +N + +K Sbjct: 240 WDILNLT-------YPQREFDAGSTINQIAFNP----KLQWVAVGTDQGVKIFNLMTQSK 288 Query: 274 SLLQLLDGS 282 + + ++ Sbjct: 289 APVCTIEAE 297 Score = 75.6 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 58/196 (29%), Gaps = 28/196 (14%) Query: 133 TISAHSEAVVSVDV-----PMNDSSILSSGSYDGLIRIFDAETGHCLKTL-TYDKDWKRE 186 + HS+ V S+ DS +L SGS D + I+ K Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 187 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 246 N +S + S+ + + S D +++WD G + F E + S Sbjct: 76 NHF--VSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSP----- 128 Query: 247 NPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHC----------F 296 ++S +I WN + + + + F Sbjct: 129 -----DNRQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPF 183 Query: 297 GNIMCSLALNGDCCLW 312 S+ +G +W Sbjct: 184 APYFASVGWDGRLKVW 199 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 31/166 (18%), Positives = 63/166 (37%), Gaps = 19/166 (11%) Query: 20 KISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFS 78 K+ P + A + +++ N + + +H + L SP+G+ IAT D Sbjct: 179 KVQPFAPYFASVGWDGRLKVWNTNFQ--IRYTFKAHESNVNHLSISPNGKYIATGGKDKK 236 Query: 79 VEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAH 137 + I + + + + + FN K + + D+ +KI++ + S + Sbjct: 237 LLIWDILNLTYPQREFDAGSTINQIAFNPKLQWVAVGT-DQGVKIFNLMTQSKAPVCTIE 295 Query: 138 SEAV-------------VSVDVPMNDSSILSSGSYDGLIRIFDAET 170 +E + S+ + + G DG+IR F ET Sbjct: 296 AEPITKAEGQKGKNPQCTSLAWNALGKKLFA-GFTDGVIRTFSFET 340 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 27/126 (21%), Positives = 47/126 (37%), Gaps = 17/126 (13%) Query: 19 AKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 ISP+G+++A +LI+DI T Q + +++ ++P Q +A D Sbjct: 219 LSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDA-GSTINQIAFNPKLQWVAVG-TDQ 276 Query: 78 SVEIIHLSYGL-----------LHTFIGHTAP---VISLTFNRKGNLLFTSSMDESIKIW 123 V+I +L + G SL +N G LF D I+ + Sbjct: 277 GVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTF 336 Query: 124 DTLNGS 129 + Sbjct: 337 SFETSA 342 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 15/95 (15%), Positives = 35/95 (36%), Gaps = 6/95 (6%) Query: 224 VRTFQVQPLEKGVLHHSCGMD-FLNPEDGSTPLVISGYENGDIYCW---NSDTKSLLQLL 279 ++ + LE + + F E+ +P++ISG + + W + + Sbjct: 9 IQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIP 68 Query: 280 DGSLYHHSSPV--MSIHCFGNIMCSLALNGDCCLW 312 +L H+ V +++ S + + LW Sbjct: 69 HKALTGHNHFVSDLALSQENCFAISSSWDKTLRLW 103 >2HES-X nrPDB Length = 330 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 111/320 (34%), Gaps = 33/320 (10%) Query: 15 KATCAKISPDGQFLAITQGLNILIYDI--NRRTVSQTLV-TSHARPFSELCWSPDGQCIA 71 K S G + I + + + T+ L T+H + + W P +A Sbjct: 16 KIWSFDFS-QGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLA 74 Query: 72 TASDDFSVEIIHLSYGLLHTFI--------GHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 S D +V I TF GH V + ++ G L T S D+S+ IW Sbjct: 75 AGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIW 134 Query: 124 DT----LNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD--AETGHCLKTL 177 +T + + HS+ V V + ++L+S SYD +RI+ + C+ L Sbjct: 135 ETDESGEEYECISVLQEHSQDVKHV-IWHPSEALLASSSYDDTVRIWKDYDDDWECVAVL 193 Query: 178 TYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVL 237 + G V S +E L S D V++W +G Q + + + +L Sbjct: 194 NGHE------GTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDD--EDDQQEWVCEAIL 245 Query: 238 HHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS-----LLQLLDGSLYHHSSPVMS 292 N G L+ S +G + + L G + + Sbjct: 246 PDVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLE 305 Query: 293 IHCFGNIMCSLALNGDCCLW 312 ++ I+ + +G W Sbjct: 306 LNGK-TILATGGDDGIVNFW 324 Score = 98.7 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 53/274 (19%), Positives = 86/274 (31%), Gaps = 63/274 (22%) Query: 10 TQNGLKATCAKISPDGQFLAITQ-GLNILIY------DINRRTVSQTLVTSHARPFSELC 62 T + P LA + I+ D ++ H + Sbjct: 55 TAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVA 114 Query: 63 WSPDGQCIATASDDFSVEIIHL-----SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMD 117 WS DG +AT S D SV I Y + H+ V + ++ LL +SS D Sbjct: 115 WSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYD 174 Query: 118 ESIKIW--DTLNGSLMKTISAHSEAVVSVDVPMNDSSI-LSSGSYDGLIRIF-------- 166 ++++IW + + ++ H V S D + L SGS D +R++ Sbjct: 175 DTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDED 234 Query: 167 DAETGHCLKTLTYDKDWKRE--------------------------------------NG 188 D + C L + +G Sbjct: 235 DQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHG 294 Query: 189 VVPISQVKFSE-NARYLL-VKSLDGVVKIWDCIG 220 V I+ VK+ E N + +L DG+V W Sbjct: 295 VYEINVVKWLELNGKTILATGGDDGIVNFWSLEK 328 Score = 87.5 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 49/240 (20%), Positives = 86/240 (35%), Gaps = 22/240 (9%) Query: 85 SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI----WDTLNGSLMKTISAHSEA 140 S L+ + + + S F++ +L T S D IK+ +D + +AH +A Sbjct: 3 SINLIKSLKLYKEKIWSFDFSQG--ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKA 60 Query: 141 VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN 200 + SV +S+L++GS+D + I+ A+ +T D E + V +S + Sbjct: 61 IRSVA-WRPHTSLLAAGSFDSTVSIW-AKEESADRTFEMDLLAIIEGHENEVKGVAWSND 118 Query: 201 ARYLLVKSLDGVVKIWDC-IGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 259 YL S D V IW+ G V + H S L+ S Sbjct: 119 GYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWH-------PSEALLASS 171 Query: 260 YENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN----IMCSLALNGDCCLWRWV 315 + + W L H V S +CS + + +W+++ Sbjct: 172 SYDDTVRIW--KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYM 229 >5K1B-B nrPDB Length = 677 Score = 128 bits (321), Expect = 3e-30, Method: Composition-based stats. Identities = 48/309 (15%), Positives = 115/309 (37%), Gaps = 33/309 (10%) Query: 25 GQFLAITQGLNILIYDIN--RRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII 82 + + I I+ +N ++ + H +++ +G+ + +AS D +V++ Sbjct: 43 NRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVW 102 Query: 83 HLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM---------K 132 + G + T H V +L + + L+ ++ +D I +WD + + Sbjct: 103 NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162 Query: 133 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 ++S + +++ S+ + +I+ SGS + ++R++D T L L D + Sbjct: 163 SLSGNKDSIYSLAMNQL-GTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTD--------NV 213 Query: 193 SQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGS 252 + + + L S DG +++W + T++V L + + Sbjct: 214 KALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRD 273 Query: 253 TPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVM------------SIHCFGNIM 300 + + N DI + K+ + ++ P + ++ N Sbjct: 274 RKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFR 333 Query: 301 CSLALNGDC 309 S + DC Sbjct: 334 ASGDYDNDC 342 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 44/229 (19%), Positives = 86/229 (37%), Gaps = 22/229 (9%) Query: 58 FSELCWSPDGQCIATASDDFSVEIIHLS----YGLLHTFIGHTAPVISLTFNRKGNLLFT 113 + L P + TA D + I ++ + + HT V + G L + Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 173 +S D ++K+W+ G M T+ H + V ++ D +++S D I ++D T Sbjct: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAK-DKELVASAGLDRQIFLWDVNT--- 148 Query: 174 LKTLTYDKDWKRENGVV----PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQV 229 L LT + + + I + ++ ++ S + V+++WD + + Sbjct: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 208 Query: 230 QPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQL 278 H L DG+ L SG +G I W+ + + Sbjct: 209 --------HTDNVKALLLNRDGTQCL--SGSSDGTIRLWSLGQQRCIAT 247 Score = 110 bits (274), Expect = 9e-25, Method: Composition-based stats. Identities = 41/220 (18%), Positives = 90/220 (40%), Gaps = 15/220 (6%) Query: 96 TAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS---LMKTISAHSEAVVSVDVPMNDSS 152 V +L + N LFT+ D I+IW + ++ H++ V + + N + Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89 Query: 153 ILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGV 212 ++S+ S D +++++A G C+ TL KD+ + + ++++ + LD Sbjct: 90 LISASS-DTTVKVWNAHKGFCMSTLRTHKDY--------VKALAYAKDKELVASAGLDRQ 140 Query: 213 VKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDT 272 + +WD + T + L + + + +++SG + W+ T Sbjct: 141 IFLWDVNTLTAL-TASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT 199 Query: 273 KSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + L L G + + + ++ G S + +G LW Sbjct: 200 CAKLMKLKG--HTDNVKALLLNRDGTQCLSGSSDGTIRLW 237 Score = 107 bits (268), Expect = 5e-24, Method: Composition-based stats. Identities = 32/211 (15%), Positives = 84/211 (39%), Gaps = 20/211 (9%) Query: 23 PDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII 82 ++ + + +++ ++ TL T H L ++ D + +A+A D + + Sbjct: 86 NGKTLISASSDTTVKVWNAHKGFCMSTLRT-HKDYVKALAYAKDKELVASAGLDRQIFLW 144 Query: 83 HLSYGLLHT----------FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK 132 ++ T G+ + SL N+ G ++ + S ++ +++WD + + Sbjct: 145 DVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLM 204 Query: 133 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 + H++ V ++ + + + L SGS DG IR++ C+ T + + Sbjct: 205 KLKGHTDNVKALLLNRDGTQCL-SGSSDGTIRLWSLGQQRCIATYRVHDE--------GV 255 Query: 193 SQVKFSENARYLLVKSLDGVVKIWDCIGGCV 223 ++ ++ ++ D + D + Sbjct: 256 WALQVNDAFTHVYSGGRDRKIYCTDLRNPDI 286 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 45/282 (15%), Positives = 94/282 (33%), Gaps = 27/282 (9%) Query: 19 AKISPDGQFLAITQ-GLNILIYDINR--------RTVSQTLVTSHARPFSELCWSPDGQC 69 + D + +A I ++D+N TV+ + ++ + L + G Sbjct: 123 LAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTI 182 Query: 70 IATASDDFSVEIIHLSY-GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 I + S + + + L GHT V +L NR G + S D +I++W Sbjct: 183 IVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQ 242 Query: 129 SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENG 188 + T H E V ++ V + + SG D I D + +K + Sbjct: 243 RCIATYRVHDEGVWALQVNDAFTH-VYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKME 301 Query: 189 VVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR-TFQVQPLEKGVLHHSCGMDFLN 247 + + ++ + V + V W G R + + C Sbjct: 302 LD-----RSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQV 356 Query: 248 PEDGSTPL----------VISGYENGDIYCWNSDTKSLLQLL 279 + G++ + +++ N ++ W+ ++ L Sbjct: 357 IKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDL 398 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 21/147 (14%), Positives = 50/147 (34%), Gaps = 11/147 (7%) Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 + ++ +D + ++ ++ L D +++IW V Sbjct: 8 NTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWS------VNQ 61 Query: 227 FQVQPLEKGVLHHSCGM-DFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYH 285 + P + HH+ + D + +G T +IS + + WN+ + L + Sbjct: 62 HKQDPYIASMEHHTDWVNDIVLCCNGKT--LISASSDTTVKVWNAHKGFCMSTL--RTHK 117 Query: 286 HSSPVMSIHCFGNIMCSLALNGDCCLW 312 ++ ++ S L+ LW Sbjct: 118 DYVKALAYAKDKELVASAGLDRQIFLW 144 >6EMK-B nrPDB Length = 303 Score = 126 bits (317), Expect = 9e-30, Method: Composition-based stats. Identities = 41/266 (15%), Positives = 98/266 (36%), Gaps = 16/266 (6%) Query: 19 AKISPDGQFLAITQGLNILIYDINRRTVSQTLV-TSHARPFSELCWSPDGQCIATASDDF 77 +I+ D + LA N+ +YDI + H + + + D + + T+S+D Sbjct: 38 LEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDG 97 Query: 78 SVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAH 137 ++++ + + H APV + + L + D +I+IWD ++ Sbjct: 98 TIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE 157 Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE--NGVVPISQV 195 + + +D S+L++ + G +++ T + I+++ Sbjct: 158 DDTSLQSLSMASDGSMLAAANTKGNCYVWEM----PNHTDASHLKPVTKFRAHSTYITRI 213 Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 S + ++L S D ++W + T H D D + Sbjct: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG-------HQRWVWDCAFSAD--SAY 264 Query: 256 VISGYENGDIYCWNSDTKSLLQLLDG 281 +++ + + W+ T+ +++ G Sbjct: 265 LVTASSDHYVRLWDLSTREIVRQYGG 290 Score = 122 bits (305), Expect = 2e-28, Method: Composition-based stats. Identities = 44/207 (21%), Positives = 92/207 (44%), Gaps = 22/207 (10%) Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 +L ++ D +I+ W+ L G +TI HS++ V+ ND +L++ + +R++ Sbjct: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKKLLATAGHQN-VRLY 58 Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 D T + ++ E ++ V F ++ R+++ S DG +K+WD + R Sbjct: 59 DIRTTNPNPVASF------EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN 112 Query: 227 FQVQ-PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYH 285 ++ P+ + V+H + G +IS +G+I W+ L Sbjct: 113 YKHNAPVNEVVIHPNQGE------------LISCDRDGNIRIWDLGENQCTHQLTPED-D 159 Query: 286 HSSPVMSIHCFGNIMCSLALNGDCCLW 312 S +S+ G+++ + G+C +W Sbjct: 160 TSLQSLSMASDGSMLAAANTKGNCYVW 186 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 49/290 (16%), Positives = 91/290 (31%), Gaps = 62/290 (21%) Query: 69 CIATASDDFSVEIIHLSYGLL--------------------------------------- 89 + +A D ++ G+ Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 Query: 90 -----HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSV 144 +F GH V S++F + + TSS D +IK+WD + S+ + H+ V V Sbjct: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEV 122 Query: 145 DVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYL 204 + N ++S DG IRI+D C LT + D + + + + L Sbjct: 123 VIHPNQGELISC-DRDGNIRIWDLGENQCTHQLTPEDD-------TSLQSLSMASDGSML 174 Query: 205 LVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGD 264 + G +W+ + P+ K H + L D + + + Sbjct: 175 AAANTKGNCYVWEMPNHTDASHLK--PVTKFRAHSTYITRILLSSD--VKHLATCSADHT 230 Query: 265 IYCWNSDTKSLLQLLDGSLYHHSSPV--MSIHCFGNIMCSLALNGDCCLW 312 W+ D L+ +L H V + + + + + LW Sbjct: 231 ARVWSIDDD---FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 Score = 87.5 bits (215), Expect = 6e-18, Method: Composition-based stats. Identities = 30/153 (19%), Positives = 59/153 (38%), Gaps = 8/153 (5%) Query: 3 QFVTPVGTQNGLKATCAKISPDGQFLAITQGL-NILIYDINRRT-----VSQTLVTSHAR 56 Q + ++ ++ DG LA N ++++ T T +H+ Sbjct: 149 QCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHST 208 Query: 57 PFSELCWSPDGQCIATASDDFSVEIIHLS--YGLLHTFIGHTAPVISLTFNRKGNLLFTS 114 + + S D + +AT S D + + + + L T GH V F+ L T+ Sbjct: 209 YITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTA 268 Query: 115 SMDESIKIWDTLNGSLMKTISAHSEAVVSVDVP 147 S D +++WD +++ H + V V + Sbjct: 269 SSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 >4YCZ-A nrPDB Length = 876 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 51/286 (17%), Positives = 98/286 (34%), Gaps = 31/286 (10%) Query: 52 TSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLH---TFIGHTAPVISLTFNR-- 106 + H + G+ +AT S D +++I + T GH V +++ Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKT--ISAHSEAVVSVDVPMND-SSILSSGSYDGLI 163 GN+L ++ D + IW LNG+ + + H +V V ++ +L+ S DG + Sbjct: 75 YGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV 134 Query: 164 RIFDAETGHCLKTLTYDKD-------WKRENGVVPISQVKFSEN---ARYLLVKSLDGVV 213 + + ++ + W I K R + D + Sbjct: 135 SVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNAL 194 Query: 214 KIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTK 273 KIW + +PL +P + S E+ + W SD Sbjct: 195 KIWAYDPATNTYKLEREPLTGHTDWVRDV--AWSPTVLQKSYIASASEDRTVRIWTSDPA 252 Query: 274 SLLQ------LLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWR 313 + LQ D +++ +S GN++ + + LW+ Sbjct: 253 NPLQWNCKVLNFDAAVWR-----VSWSLSGNVLAASGGDNKVTLWK 293 Score = 78.3 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 28/200 (14%), Positives = 69/200 (34%), Gaps = 36/200 (18%) Query: 15 KATCAKISP--DGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP------ 65 SP G LA + N+ + + + ++ +H + + W+P Sbjct: 110 SVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGS 169 Query: 66 -----------DGQCIATASDDFSVEII--HLSYGLLH----TFIGHTAPVISLTFNRK- 107 + T D +++I + GHT V + ++ Sbjct: 170 IVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTV 229 Query: 108 --GNLLFTSSMDESIKIWDTLNGSLMK---TISAHSEAVVSVDVPMNDSSILSSGSYDGL 162 + + ++S D +++IW + + ++ + AV V + ++L++ D Sbjct: 230 LQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSL-SGNVLAASGGDNK 288 Query: 163 IRIFDA---ETGHCLKTLTY 179 + ++ C+KT+ Sbjct: 289 VTLWKENLKGEWECVKTIEE 308 >2AQ5-A nrPDB Length = 402 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 55/273 (20%), Positives = 102/273 (37%), Gaps = 35/273 (12%) Query: 19 AKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG-QCIATASDDF 77 + S G FL + G R + LV H P ++ W P IA+ S+D Sbjct: 51 CEASGGGAFLVLPLGKT------GRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDC 104 Query: 78 SVEIIHLSYGLLH--------TFIGHTAPVISLTFNRKG-NLLFTSSMDESIKIWDTLNG 128 +V + + G L T GHT V + ++ N+L ++ D I +WD G Sbjct: 105 TVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTG 164 Query: 129 SLMKTISA--HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 186 + + T+ H + + SVD D +++ + D +R+ + G + + + Sbjct: 165 AAVLTLGPDVHPDTIYSVDWS-RDGALICTSCRDKRVRVIEPRKGTVVA-----EKDRPH 218 Query: 187 NGVVPISQVKFSENARYLLVK---SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGM 243 G P+ V F + L + V +WD +PL L S G+ Sbjct: 219 EGTRPVHAV-FVSEGKILTTGFSRMSERQVALWDTKHLE-------EPLSLQELDTSSGV 270 Query: 244 DFLNPEDGSTPLVISGYENGDIYCWNSDTKSLL 276 + + + + G + I + +++ Sbjct: 271 LLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPF 303 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 39/215 (18%), Positives = 73/215 (33%), Gaps = 19/215 (8%) Query: 94 GHTAPVISLTFNR-KGNLLFTSSMDESIKIWDTLNG-------SLMKTISAHSEAVVSVD 145 GHTAPV+ + + N++ + S D ++ +W+ +G + T+ H++ V V Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 146 VPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLL 205 ++L S D +I ++D TG + TL + I V +S + + Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTL------GPDVHPDTIYSVDWSRDGALIC 192 Query: 206 VKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDI 265 D V++ + G VV +H E S + Sbjct: 193 TSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVH-----AVFVSEGKILTTGFSRMSERQV 247 Query: 266 YCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIM 300 W++ L + NI+ Sbjct: 248 ALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIV 282 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 33/224 (14%), Positives = 84/224 (37%), Gaps = 29/224 (12%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDINRRTVSQTL------VTSHARPFSELCWSPD-GQ 68 A C D + ++ +++++I + L + H + + W P Sbjct: 88 AWCP--HNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQN 145 Query: 69 CIATASDDFSVEIIHLSYGLLHTFIG---HTAPVISLTFNRKGNLLFTSSMDESIKIWDT 125 + +A D + + + G +G H + S+ ++R G L+ TS D+ +++ + Sbjct: 146 VLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEP 205 Query: 126 LNGSLM----KTISAHSEAVVSVDVPMNDSSILSSG-SY--DGLIRIFDAETGHCLKTLT 178 G+++ + + V +V V + IL++G S + + ++D + L Sbjct: 206 RKGTVVAEKDRPHEG-TRPVHAVFVS--EGKILTTGFSRMSERQVALWDTKH------LE 256 Query: 179 YDKDWKRENGVVPISQVKFSENARYL-LVKSLDGVVKIWDCIGG 221 + + + F + + L D ++ ++ Sbjct: 257 EPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSE 300 Score = 70.9 bits (172), Expect = 7e-13, Method: Composition-based stats. Identities = 43/179 (24%), Positives = 67/179 (37%), Gaps = 17/179 (9%) Query: 7 PVGTQNGLKATC--AKISPDGQ--FLAITQGLNILIYDINRRTVSQTLVTS-HARPFSEL 61 PV T G P Q L+ IL++D+ TL H + Sbjct: 123 PVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSV 182 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFI--GH--TAPVISLTFNRKGNLLFTS--- 114 WS DG I T+ D V +I G + H T PV ++ F +G +L T Sbjct: 183 DWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSR 241 Query: 115 -SMDESIKIWDTLN-GSLMKTISAHSEAVVSVDVPMNDSSIL-SSGSYDGLIRIFDAET 170 S + +WDT + + + + V + D++I+ G D IR F+ + Sbjct: 242 MSE-RQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITS 299 Score = 59.0 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 16/126 (12%), Positives = 46/126 (36%), Gaps = 3/126 (2%) Query: 187 NGVVPISQVKFSE-NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF 245 P+ + + N + S D V +W+ G +V + + + H+ + Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVIT--LEGHTKRVGI 136 Query: 246 LNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLAL 305 + + +++S + I W+ T + + L ++ + + G ++C+ Sbjct: 137 VAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCR 196 Query: 306 NGDCCL 311 + + Sbjct: 197 DKRVRV 202 >5FVM-C nrPDB Length = 303 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 43/264 (16%), Positives = 101/264 (38%), Gaps = 12/264 (4%) Query: 19 AKISPDGQFLAITQGLNILIYDINRRTVSQTLV-TSHARPFSELCWSPDGQCIATASDDF 77 +I+ D ++LA L++ +YDI + H + + + + + + ++S+D Sbjct: 38 LEITSDKKYLAAAGHLHVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDG 97 Query: 78 SVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAH 137 ++++ + + H APV + + L + D +I+IWD ++ Sbjct: 98 TIKVWDVRSPSVQRNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPE 157 Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 + +D S+L +G+ G ++ TL + K ++ I++V Sbjct: 158 DNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTL--EPVTKFKSHTKYITRVLL 215 Query: 198 SENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVI 257 S + + L S D ++W+ + T H D D + ++ Sbjct: 216 SADVKNLATCSADHTARVWNIEDNYQLETTLDG-------HQRWVWDCAFSAD--SAYLV 266 Query: 258 SGYENGDIYCWNSDTKSLLQLLDG 281 + + + W+ T +++ G Sbjct: 267 TACSDHYVRLWDLSTSEIVRQYGG 290 Score = 124 bits (311), Expect = 5e-29, Method: Composition-based stats. Identities = 50/290 (17%), Positives = 91/290 (31%), Gaps = 62/290 (21%) Query: 69 CIATASDDFSVEIIHLSYGLLHT------------------------------------- 91 +A+A D ++ G+ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSN 63 Query: 92 -------FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSV 144 F GH V S+ F ++ + +SS D +IK+WD + S+ + H+ V V Sbjct: 64 NPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEV 122 Query: 145 DVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYL 204 + N ++S DG IRI+D C LT + + P+ + + + L Sbjct: 123 AIHPNQGELISC-DQDGNIRIWDLGENQCTNQLTPEDN-------TPLQSLSVASDGSML 174 Query: 205 LVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGD 264 + + G +W T + P+ K H L D + + + Sbjct: 175 VAGNNKGNCYVWRMPHHTDASTLE--PVTKFKSHTKYITRVLLSAD--VKNLATCSADHT 230 Query: 265 IYCWNSDTKSLLQLLDGSLYHHSSPV--MSIHCFGNIMCSLALNGDCCLW 312 WN + L+ +L H V + + + + LW Sbjct: 231 ARVWNIEDN---YQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLW 277 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 39/210 (18%), Positives = 91/210 (43%), Gaps = 26/210 (12%) Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 +L ++ D +I+ W+ L G +TI V +++ + + ++G +R++ Sbjct: 1 MSVILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHL--HVRLY 58 Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 D + + ++ E ++ + F + R+++ S DG +K+WD V R Sbjct: 59 DIRSNNPNPVSSF------EGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRN 112 Query: 227 FQVQ-PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYH 285 ++ P+ + +H + G +IS ++G+I W+ L Sbjct: 113 YKHNAPVNEVAIHPNQGE------------LISCDQDGNIRIWDLGENQCTNQL---TPE 157 Query: 286 HSSPV--MSIHCFGNIMCSLALNGDCCLWR 313 ++P+ +S+ G+++ + G+C +WR Sbjct: 158 DNTPLQSLSVASDGSMLVAGNNKGNCYVWR 187 Score = 87.9 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 31/153 (20%), Positives = 60/153 (39%), Gaps = 8/153 (5%) Query: 3 QFVTPVGTQNGLKATCAKISPDGQFLAITQGL-NILIYDINRRTVSQTLVT-----SHAR 56 Q + ++ ++ DG L N ++ + T + TL SH + Sbjct: 149 QCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTK 208 Query: 57 PFSELCWSPDGQCIATASDDFSVEIIHL--SYGLLHTFIGHTAPVISLTFNRKGNLLFTS 114 + + S D + +AT S D + + ++ +Y L T GH V F+ L T+ Sbjct: 209 YITRVLLSADVKNLATCSADHTARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTA 268 Query: 115 SMDESIKIWDTLNGSLMKTISAHSEAVVSVDVP 147 D +++WD +++ H + V V + Sbjct: 269 CSDHYVRLWDLSTSEIVRQYGGHHKGAVCVALN 301 >5WJC-A nrPDB Length = 430 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 105/277 (37%), Gaps = 39/277 (14%) Query: 26 QFLAI-TQGLNILIYDIN-------RRTVSQTLVTSHARPFSELCWSPD-GQCIATASDD 76 + +A +G N I+D + Q ++ H LCW+P+ +AT ++D Sbjct: 145 EIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAED 204 Query: 77 FSVEIIHLSYGL-----------LHTFIGHTAPVISLTFNRKGN-LLFTSSMDESIKIWD 124 + + + + + HT V + F+ + LL + S D +++I D Sbjct: 205 QVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHD 264 Query: 125 TLNG---SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG-HCLKTLTYD 180 T K I AHS+A+ +V + + +L++ S D + ++D L TL Sbjct: 265 TRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLEGH 324 Query: 181 KDWKRENGVVPISQVKFSE-NARYLLVKSLDGVVKIWDCIGGCVVRTFQ-----VQPLEK 234 +D + +++S + L S D V IWD +T + L Sbjct: 325 ED--------EVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLF 376 Query: 235 GVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 H+ + + +V S ++ + W+ Sbjct: 377 MHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPS 413 Score = 115 bits (288), Expect = 2e-26, Method: Composition-based stats. Identities = 47/221 (21%), Positives = 94/221 (42%), Gaps = 25/221 (11%) Query: 21 ISPD--GQFLAITQGLNILIYDINRR--TVSQTLVTS-------HARPFSELCWSP-DGQ 68 +P+ G + I ++D+ + T S+T V S H +++ + P Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 69 CIATASDDFSVEIIHLSYG----LLHTFIGHTAPVISLTFNRKGNLL-FTSSMDESIKIW 123 +A+ SDD +++I H+ + ++ N + L T+S D+++ +W Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALW 309 Query: 124 DTLNG-SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 D N + T+ H + V ++ +D IL+S S D + I+D E +T +D Sbjct: 310 DLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAED 369 Query: 183 WKRE------NGVVPISQVKFSENARYLL-VKSLDGVVKIW 216 E IS+ + N R+++ + D +++IW Sbjct: 370 GSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIW 410 Score = 76.7 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 83/239 (34%), Gaps = 24/239 (10%) Query: 89 LHTFIGHTAPVISLTFNR-KGNLLFTSSMDESIKIWDTLNGSLMKT--------ISAHSE 139 + I H V + K ++ T + I+DT + T + H+ Sbjct: 124 ISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTA 183 Query: 140 AVVSVDVPMNDSSILSSGSYDGLIRIFDAET--GHCLKTLTYDKDWKRENGVVPISQVKF 197 + N L++G+ D +I ++D +T +T K ++ V+F Sbjct: 184 EGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQF 243 Query: 198 SENARYLL-VKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLV 256 LL S D ++I D + K + HS ++ + + L+ Sbjct: 244 HPQHEALLASVSDDCTLQIHDTRLNP------EEEAPKVIQAHSKAINAVAINPFNDYLL 297 Query: 257 ISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH---CFGNIMCSLALNGDCCLW 312 + + + W+ ++ Q L +L H V + I+ S + + C+W Sbjct: 298 ATASADKTVALWDL--RNPYQRLH-TLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIW 353 >5XYI-g nrPDB Length = 335 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 57/329 (17%), Positives = 114/329 (34%), Gaps = 44/329 (13%) Query: 6 TPVGTQNGLKATCAKISPDGQ---FLAITQGLNILIYDINR----RTVSQTLVTSHARPF 58 P T G A I D + ++ ++ + L++ +NR T + H Sbjct: 24 APRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFV 83 Query: 59 SELCWSPDGQCIATASDDFSVEIIHLSYGLLHT-FIGHTAPVISLTFNRKGNLLFTSSMD 117 S++ S D + T+S D ++ + LS F+GH V+ +TF+ + + D Sbjct: 84 SDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRD 143 Query: 118 ESIKIWDTLNGSLMKTISAHSEAVVSVDVPM----NDSSILSSGSYDGLIRIFDAET-GH 172 +KIW+ L + + S V SV +++ G +DG + I+ E Sbjct: 144 NQVKIWNILGENKAELQC--SSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAK 201 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 232 +K + V F+ + ++++ D V +W G Sbjct: 202 LIKEFKAHDGRC--------TSVDFTPDGKWVITGGSDRKVVMWLTENGA---------- 243 Query: 233 EKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSS---- 288 K + + + + + G I W+ K + L+ + H Sbjct: 244 -KTISFTAPSPVHAVAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAG 301 Query: 289 -----PVMSIHCFGNIMCSLALNGDCCLW 312 ++ G+++ S +G W Sbjct: 302 RTPDCTCLAWAADGSVLYSGYNDGSIRAW 330 Score = 95.6 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 33/251 (13%), Positives = 79/251 (31%), Gaps = 51/251 (20%) Query: 19 AKISPDGQ-FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 +S D L + + ++D++ RT + + H + + +SP + I + D Sbjct: 86 VSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFL-GHKKDVLGVTFSPCNRRIISVGRDN 144 Query: 78 SVEIIHLSYGLLHTFIGHTAPVISLTFNRKGN-----LLFTSSMDESIKIWDTLN-GSLM 131 V+I ++ G + ++ V S+ + ++ D + IW L+ Sbjct: 145 QVKIWNI-LGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLI 203 Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIR--------------------------- 164 K AH SVD + +++ GS ++ Sbjct: 204 KEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPSPVHAVAACPTQ 263 Query: 165 ------------IFDAETGHCLKTLTY---DKDWKRENGVVPISQVKFSENARYLLVKSL 209 ++D + + + + + + ++ + L Sbjct: 264 AWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYN 323 Query: 210 DGVVKIWDCIG 220 DG ++ W+ Sbjct: 324 DGSIRAWEVKS 334 >3ACP-A nrPDB Length = 417 Score = 119 bits (298), Expect = 1e-27, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 102/265 (38%), Gaps = 39/265 (14%) Query: 69 CIATASDDFSVEIIHLSYGLLHTF-IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 + T D ++++ ++ L H + + L F G L +SS D +KIW + Sbjct: 110 ILGTTEGD--IKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKD 167 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN 187 GS +T+ H V + + ++L S S DG IR+++ TG + T ++ + Sbjct: 168 GSNPRTLIGHRATVTDIAIIDRGRNVL-SASLDGTIRLWECGTGTTIHTF--NRKENPHD 224 Query: 188 GVVPI------------------SQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQV 229 GV I + ++F +Y++ + GV+ + + +T Q+ Sbjct: 225 GVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKE--QTIQL 282 Query: 230 QPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSL---LQLLDGSLYHH 286 +C + L + + + +GYENG + W+ + L++ + Sbjct: 283 PS------KFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPIN 336 Query: 287 SSPVMSIHCFGNIMCSLALNGDCCL 311 + G + S + L Sbjct: 337 NV----YFAAGALFVSSGFDTSIKL 357 Score = 44.7 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 20/111 (18%), Positives = 40/111 (36%), Gaps = 12/111 (10%) Query: 202 RYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE 261 R ++ + +G +K+ D Q E L + +IS + Sbjct: 107 RRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEA----------LISSSQ 156 Query: 262 NGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + + W+ S + L G + + ++I G + S +L+G LW Sbjct: 157 DMQLKIWSVKDGSNPRTLIG--HRATVTDIAIIDRGRNVLSASLDGTIRLW 205 >4XYI-A nrPDB Length = 430 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 43/216 (19%), Positives = 88/216 (40%), Gaps = 23/216 (10%) Query: 24 DGQFLAITQGLNILIYDINRRTVSQTLVTS---------HARPFSELCWS-PDGQCIATA 73 +G T+ +I ++DI +++S H ++L + + + Sbjct: 195 EGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSV 254 Query: 74 SDDFSVEIIHL----SYGLLHTFIGHTAPVISLTFNRKGNLL-FTSSMDESIKIWDTLN- 127 SDD +++I S H PV + FN + L T+S D ++ +WD Sbjct: 255 SDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRL 314 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE- 186 + T+ H + V +V +D IL + S D + ++D +T+ +D E Sbjct: 315 NQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPEL 374 Query: 187 -----NGVVPISQVKFSENARYLLVK-SLDGVVKIW 216 +S + ++ N +++L + D +++IW Sbjct: 375 MFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 Score = 114 bits (284), Expect = 7e-26, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 108/287 (37%), Gaps = 42/287 (14%) Query: 19 AKISPDG-QFLAI-TQGLNILIYDINRR-------TVSQTLVTSHARPFSELCWS--PDG 67 A+ P +A N I+D+N T Q + H L W+ +G Sbjct: 137 ARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLGWNFIQEG 196 Query: 68 QCIATASDDFSVEIIHLSYGLLH-----------TFIGHTAPVISLTFNRKGNLLFTS-S 115 +AT ++D S+ + + L + HTA V L F+ + L TS S Sbjct: 197 T-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVS 255 Query: 116 MDESIKIWDTL---NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET-G 171 D +++I DT + S + + AH + V V + +L++ S D + ++D Sbjct: 256 DDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLN 315 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSE-NARYLLVKSLDGVVKIWDCIGGCVVRTFQ-- 228 L TL +D + V++S + L+ S D V +WD +T + Sbjct: 316 QRLHTLEGHED--------EVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDS 367 Query: 229 ---VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDT 272 L H+ + L+ + ++ S ++ + W+ Sbjct: 368 EDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSK 414 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 35/240 (14%), Positives = 83/240 (34%), Gaps = 24/240 (10%) Query: 88 LLHTFIGHTAPVISLTFNRKG-NLLFTSSMDESIKIWDT---LNGSLMKT-----ISAHS 138 + I H V F + +++ T ++ + I+D +++T + H+ Sbjct: 123 DIVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHT 182 Query: 139 EAVVSVDVPMNDSSILSSGSYDGLIRIFDA--ETGHCLKTLTYDKDWKRENGVVPISQVK 196 + L++G+ D I ++D ++ K++ ++ ++ Sbjct: 183 SEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQ 242 Query: 197 FSENARYLLVK-SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 F LL S D ++I D Q + ++ F + L Sbjct: 243 FHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPF------NDYL 296 Query: 256 VISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH---CFGNIMCSLALNGDCCLW 312 + + + + W+ + L Q L +L H V ++ I+ + + + C+W Sbjct: 297 LATASADHTVALWDL--RRLNQRLH-TLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVW 353 >3ODT-A nrPDB Length = 313 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 122/289 (42%), Gaps = 35/289 (12%) Query: 29 AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD---FSVEIIHLS 85 ++++ + ++ + + + T+V + + +C+ + + + D V + S Sbjct: 34 SVSRDGTVRLWSKDDQWLG-TVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFATS 92 Query: 86 YGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSV 144 L+T IGH V SL+F + G ++ + S D++ K+W GSL+ + AH+ +V Sbjct: 93 GEDPLYTLIGHQGNVCSLSF-QDG-VVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDA 148 Query: 145 DVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY-DKDWKRENGVVPISQVKFSENARY 203 V + + S D I+++ + +KT + D R VV + + Sbjct: 149 KVVSFSENKFLTASADKTIKLW--QNDKVIKTFSGIHNDVVRHLAVV---------DDGH 197 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENG 263 + S DG++K+ D G V+RT++ + D ++S E+ Sbjct: 198 FISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-----------IVSCGEDR 246 Query: 264 DIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + W+ + SL Q++ +L S + G+I+ + + ++ Sbjct: 247 TVRIWSKENGSLKQVI--TLPAISIWSVDCMSNGDIIV-GSSDNLVRIF 292 Score = 105 bits (262), Expect = 2e-23, Method: Composition-based stats. Identities = 42/159 (26%), Positives = 74/159 (46%), Gaps = 8/159 (5%) Query: 15 KATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 74 A S + +FL + I ++ ++ V +T H L DG I + S Sbjct: 147 DAKVVSFS-ENKFLTASADKTIKLWQNDK--VIKTFSGIHNDVVRHLAVVDDGHFI-SCS 202 Query: 75 DDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 133 +D ++++ + G +L T+ GH + V + G+ + + D +++IW NGSL + Sbjct: 203 NDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENGSLKQV 261 Query: 134 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 I+ + ++ SVD N I+ GS D L+RIF E Sbjct: 262 ITLPAISIWSVDCMSNGDIIV--GSSDNLVRIFSQEKSR 298 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 87/234 (37%), Gaps = 29/234 (12%) Query: 43 RRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISL 102 + H L + DG + + S D + ++ L++ H A V Sbjct: 92 SGEDPLYTLIGHQGNVCSLSF-QDG-VVISGSWDKTAKVWKEGS-LVYNLQAHNASVWDA 148 Query: 103 TF-NRKGNLLFTSSMDESIKIWDTLNGSLMKTISA-HSEAVVSVDVPMNDSSILSSGSYD 160 + N T+S D++IK+W N ++KT S H++ V + V + I S S D Sbjct: 149 KVVSFSENKFLTASADKTIKLW--QNDKVIKTFSGIHNDVVRHLAVVDDGHFI--SCSND 204 Query: 161 GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIG 220 GLI++ D TG L+T + + + +K N ++ D V+IW Sbjct: 205 GLIKLVDMHTGDVLRTYEGHESF--------VYCIKLLPNGD-IVSCGEDRTVRIWSKEN 255 Query: 221 GCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS 274 G + + + + + D +I G + + ++ + Sbjct: 256 GSLKQVITLPAISIWSVDCMSNGD-----------IIVGSSDNLVRIFSQEKSR 298 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 38/184 (20%), Positives = 69/184 (37%), Gaps = 28/184 (15%) Query: 133 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 T+ H + V V + ++S S DG +R++ + L T+ Y G + Sbjct: 13 TLKGHDQDVRDVVAVDDSK--VASVSRDGTVRLWS-KDDQWLGTVVYT-------GQGFL 62 Query: 193 SQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGS 252 + V + LL D ++ G + T PL ++ H + L+ +DG Sbjct: 63 NSVCYDSEKELLLFGGKDTMIN-----GVPLFATSGEDPL-YTLIGHQGNVCSLSFQDG- 115 Query: 253 TPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMS---IHCFGNIMCSLALNGDC 309 +VISG + W SL+ L H++ V + N + + + Sbjct: 116 --VVISGSWDKTAKVW--KEGSLVYNLQ----AHNASVWDAKVVSFSENKFLTASADKTI 167 Query: 310 CLWR 313 LW+ Sbjct: 168 KLWQ 171 >5K0Y-T nrPDB Length = 329 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 44/221 (19%), Positives = 93/221 (42%), Gaps = 11/221 (4%) Query: 92 FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDS 151 GH + + +NR+G+LLFT + D + +W ++NG + T H+ AV VD D+ Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADW-DT 64 Query: 152 SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG 211 + +GS D R++D ETG L L + + + + FS + + Sbjct: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQM----GYQC 120 Query: 212 VVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSD 271 V +D + +P K + S + G +I+G+E+G++ +++ Sbjct: 121 FVSFFDLRDPSQIDN--NEPYMKIPCNDSKITSAVWGPLGEC--IIAGHESGELNQYSAK 176 Query: 272 TKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + +L ++ + + + + + + + L+ Sbjct: 177 SGEVL--VNVKEHSRQINDIQLSREMTMFVTASKDNTAKLF 215 Score = 99.4 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 36/259 (13%), Positives = 85/259 (32%), Gaps = 21/259 (8%) Query: 50 LVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKG 108 L+ H R +++ ++ +G + T + D V + + G L T++GHT V + + Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 109 NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSG----SYDGLIR 164 + T S D S ++WD G + + + AV + + I+ S Y + Sbjct: 65 KHVLTGSADNSCRLWDCETGKQLALLKT-NSAVRTCGFDFGGNIIMFSTDKQMGYQCFVS 123 Query: 165 IFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVV 224 FD + + K I+ + ++ G + + G V+ Sbjct: 124 FFDLR--DPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVL 181 Query: 225 RTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLY 284 + + + S + ++ ++ ++S T + Sbjct: 182 VNVKEHSRQINDIQLSR----------EMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPP 231 Query: 285 HHSSPVMSIHCFGNIMCSL 303 + ++ + Sbjct: 232 R---ELAALSPNYEHVVVG 247 Score = 70.9 bits (172), Expect = 7e-13, Method: Composition-based stats. Identities = 28/167 (16%), Positives = 59/167 (35%), Gaps = 9/167 (5%) Query: 56 RPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTS 114 + W P G+CI + + G +L H+ + + +R+ + T+ Sbjct: 147 SKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTA 206 Query: 115 SMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET--GH 172 S D + K++D+ KT +E + + + G + + T G Sbjct: 207 SKDNTAKLFDSTTLEHQKTFR--TEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGK 264 Query: 173 CLKTLTY----DKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 + ++ + + PI+ V F + + DG V+I Sbjct: 265 FEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 38/125 (30%), Gaps = 17/125 (13%) Query: 27 FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD----------- 75 F+ ++ ++D +T T R + L SP+ + + Sbjct: 203 FVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAAL--SPNYEHVVVGGGQEAMDVTTTST 260 Query: 76 ---DFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 131 F HL++ GH P+ S+ F+ G + D ++I Sbjct: 261 RIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFE 320 Query: 132 KTISA 136 A Sbjct: 321 FEFEA 325 >6BX3-B nrPDB Length = 412 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 58/330 (17%), Positives = 127/330 (38%), Gaps = 41/330 (12%) Query: 11 QNGLKATCAKISPDGQFLA-ITQGLNILIYDINRRTVS---QTLVTSHARPFSELCWSPD 66 +N L+ C + SP G +LA ++IYD++ ++ +H RP + + WSPD Sbjct: 23 ENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD 82 Query: 67 GQCIATASDDFSVEIIHLSY-GLLHTFIGHTAPVISLTFNRKGNLLFTS----------- 114 G+ + T+S D+S+++ LS I +P+ + L + Sbjct: 83 GRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVI 142 Query: 115 --SMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLI---RIFDAE 169 S D + + + + H V+ V +I+ G+ G + + Sbjct: 143 DFSNDPVASLLSKSDEKQLSSTPDH-GYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLY 201 Query: 170 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI--GGCVVRTF 227 C+ +L + V S+N L + D ++ ++ Sbjct: 202 QTECIHSLKITSSNIKHLIV--------SQNGERLAINCSDRTIRQYEISIDDENSAVEL 253 Query: 228 QVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS--GYENGDIYCWNSDTKSLLQLLDGSLYH 285 ++ + V++ L + + LV S G ++Y W + + +L+++L+G+ Sbjct: 254 TLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGA--- 310 Query: 286 HSSPVMSIH---CFGNIMCSLALNGDCCLW 312 ++ I+ +I+ + +G+ +W Sbjct: 311 -EEELIDINWDFYSMSIVSNGFESGNVYVW 339 >5A31-R nrPDB Length = 386 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 53/303 (17%), Positives = 110/303 (36%), Gaps = 30/303 (9%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 + S LA+ G +I + D N V + ++ L W G +A Sbjct: 95 YSLIDWS-STDVLAVALGKSIFLTDNNTGDVVH--LCDTENEYTSLSWIGAGSHLAVGQA 151 Query: 76 DFSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK-T 133 + VEI + + T GH V L++N ++L + S D I D T Sbjct: 152 NGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRDHRILHRDVRMPDPFFET 209 Query: 134 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 193 I +H++ V + + D + L+SG D ++ +++ + + T K + Sbjct: 210 IESHTQEVCGLKWNVAD-NKLASGGNDNVVHVYEGTSKSPILTFDEHK--------AAVK 260 Query: 194 QVKFSENARYLLV---KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 + +S + R +L + D +KIW+ + ++ + + Sbjct: 261 AMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSH- 319 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 GY ++ W+ ++ + +L G + +++ G + S A + Sbjct: 320 --------GYSKYNLTLWDCNSMDPIAILKG--HSFRVLHLTLSNDGTTVVSGAGDETLR 369 Query: 311 LWR 313 W+ Sbjct: 370 YWK 372 Score = 98.7 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 51/261 (19%), Positives = 99/261 (37%), Gaps = 29/261 (11%) Query: 15 KATCAKISPDGQFLAITQGLN-ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 + T G LA+ Q + IYD+ +R +TL + H + L W + + + Sbjct: 133 EYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTL-SGHIDRVACLSW--NNHVLTSG 189 Query: 74 SDDFSV--EIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 131 S D + + + T HT V L +N N L + D + +++ + S + Sbjct: 190 SRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPI 249 Query: 132 KTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTLTYDKDWKRENGV 189 T H AV ++ + +L++ G+ D ++I++ T + + + Sbjct: 250 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI---------DSG 300 Query: 190 VPISQVKFSENARYLLV--KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLN 247 I + +S+N L+ + +WDC + + L S Sbjct: 301 SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS------- 353 Query: 248 PEDGSTPLVISGYENGDIYCW 268 DG+T V+SG + + W Sbjct: 354 -NDGTT--VVSGAGDETLRYW 371 Score = 64.8 bits (156), Expect = 4e-11, Method: Composition-based stats. Identities = 35/209 (16%), Positives = 68/209 (32%), Gaps = 49/209 (23%) Query: 8 VGTQNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD 66 + T +G A +S + L ++ IL D+ + SH + L W+ Sbjct: 166 IRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVA 225 Query: 67 GQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGN-LLFTSS--MDESIKI 122 +A+ +D V + + + TF H A V ++ ++ +L T D +KI Sbjct: 226 DNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKI 285 Query: 123 WDTLNG-------------------------------------------SLMKTISAHSE 139 W+ + + HS Sbjct: 286 WNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSF 345 Query: 140 AVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 V+ + + ND + + SG+ D +R + Sbjct: 346 RVLHLTLS-NDGTTVVSGAGDETLRYWKL 373 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 56/139 (40%), Gaps = 11/139 (7%) Query: 6 TPVGTQNGLKATC--AKISPDGQ-FLAI---TQGLNILIYDINRRTVSQTLVTSHARPFS 59 +P+ T + KA SP + LA T + I+++N + + Sbjct: 247 SPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSG--SQIC 304 Query: 60 ELCWSPDGQCIAT--ASDDFSVEIIHLSY-GLLHTFIGHTAPVISLTFNRKGNLLFTSSM 116 + WS + + T +++ + + + GH+ V+ LT + G + + + Sbjct: 305 NMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAG 364 Query: 117 DESIKIWDTLNGSLMKTIS 135 DE+++ W + S++ + Sbjct: 365 DETLRYWKLFDVSVLNLFT 383 >5OQL-X nrPDB Length = 630 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 40/271 (14%), Positives = 86/271 (31%), Gaps = 35/271 (12%) Query: 34 LNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY-GLLHTF 92 I + R + H + + S DG+ + T D + + + + + F Sbjct: 225 ERICFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAF 284 Query: 93 IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSS 152 H V L F R N L++ S D ++K+W + ++T+ H + ++ +D + Sbjct: 285 TQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDA-LGQER 343 Query: 153 ILSSGSYDGLIRIFDA---------------ETGHCLKTLTYDKDWKRENGVVPISQVKF 197 +S G+ D R + + L D + +V Sbjct: 344 CVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAM 403 Query: 198 SENARYLLVKSLDGVVKIWDCIGGCVVRT----------FQVQPLEKGVLHHSCGMDFLN 247 ++ + S +G + +W + +++ + + Sbjct: 404 IDDD-MFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQ 462 Query: 248 PED-------GSTPLVISGYENGDIYCWNSD 271 P + L+ SG +G I W Sbjct: 463 PRGITALRTLPYSDLIFSGSWDGCIRVWRLS 493 Score = 91.4 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 40/264 (15%), Positives = 94/264 (35%), Gaps = 52/264 (19%) Query: 90 HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN 149 T+ GH + + ++ G + T D+ + +++ + +K + H +AV + Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAF-RR 298 Query: 150 DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSL 209 ++ L S S D ++++ + ++TL +D I + R + V + Sbjct: 299 GTNQLYSCSKDRTVKVWSLDELAYVETLFGHQD--------EILDIDALGQERCVSVGAR 350 Query: 210 DGVVKIWDCI-------------GGCVVRTFQVQP-LEKGVLHHSCGMDFLNPEDGSTPL 255 D + W G + ++ P ++ H MD + D + Sbjct: 351 DRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDD--M 408 Query: 256 VISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPV------------------------- 290 ++G +NGD+ W+ K L ++ + P+ Sbjct: 409 FVTGSDNGDLALWSIQRKKPLHVI-ARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGIT 467 Query: 291 -MSIHCFGNIMCSLALNGDCCLWR 313 + + +++ S + +G +WR Sbjct: 468 ALRTLPYSDLIFSGSWDGCIRVWR 491 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 34/251 (13%), Positives = 81/251 (32%), Gaps = 49/251 (19%) Query: 18 CAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 K S DG+F+ +++Y+ + T H + L + + + S D Sbjct: 251 VVKASQDGKFVVTGGADKRLVVYNAADLKPIKAF-TQHRDAVTGLAFRRGTNQLYSCSKD 309 Query: 77 FSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 +V++ L + T GH ++ + + + + D + + W S + Sbjct: 310 RTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQL-VFR 368 Query: 136 A------------------------HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 171 H ++ V + +D + +GS +G + ++ + Sbjct: 369 GGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDD--MFVTGSDNGDLALWSIQRK 426 Query: 172 HCLKTLT-------------YDKDWKRENGVVP------ISQVKFSENARYLLVKSLDGV 212 L + Y D + ++P I+ ++ + + S DG Sbjct: 427 KPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGC 486 Query: 213 VKIWDCIGGCV 223 +++W Sbjct: 487 IRVWRLSEDKR 497 Score = 54.0 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 29/230 (12%), Positives = 69/230 (30%), Gaps = 39/230 (16%) Query: 89 LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW---DTLNGSLMKTISAHSEAVVSVD 145 F ++ V S+ +T++ D + W D +T + + Sbjct: 163 YTQFRWNSGTVTSVAVCP--PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPP 220 Query: 146 VPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLL 205 + + DA + D + + VK S++ ++++ Sbjct: 221 KKRPERICFAKA---------DARKAN---------DKTYQGHLKAPLVVKASQDGKFVV 262 Query: 206 VKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDI 265 D + +++ ++ F L G T + S ++ + Sbjct: 263 TGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRG----------TNQLYSCSKDRTV 312 Query: 266 YCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFG--NIMCSLALNGDCCLWR 313 W+ D + ++ L G H ++ I G + A + W+ Sbjct: 313 KVWSLDELAYVETLFG----HQDEILDIDALGQERCVSVGARDRTARYWK 358 >4L9O-A nrPDB Length = 349 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 63/280 (22%), Positives = 99/280 (35%), Gaps = 23/280 (8%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHL---SYGLLHTFIGHTAPVISLTFN 105 T+ +H + G+ +AT S D +++I + + L+ T IGH PV + + Sbjct: 63 TIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWA 122 Query: 106 RK--GNLLFTSSMDESIKIWDTLNGSLMKT--ISAHSEAVVSVDV-PMNDSSILSSGSYD 160 G +L + S D + IW NG K S H +V SV P +L S D Sbjct: 123 HPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSD 182 Query: 161 GLIRIFDAETGHCLK--TLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW-- 216 G I I + + G L+ + PIS +N R + D +VKIW Sbjct: 183 GKISIVEFKDGGALEPIVIQGHAIGVNAASWAPIS---LPDNTRRFVSGGCDNLVKIWRY 239 Query: 217 DCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLL 276 D + Q V + L S + + ++ + W D KS Sbjct: 240 DDAAKTFIEEEAFQGHSDWVRDVAWSPSRL-----SKSYIATASQDRTVLIWTKDGKSNK 294 Query: 277 QLLDGSLYHHSSPVM---SIHCFGNIMCSLALNGDCCLWR 313 V S GN++ + LW+ Sbjct: 295 WEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWK 334 Score = 33.2 bits (74), Expect = 0.15, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 28/82 (34%), Gaps = 10/82 (12%) Query: 12 NGLKATC--AKISPD---GQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELC--- 62 G SP ++A +Q +LI+ + ++ F ++C Sbjct: 253 QGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRA 312 Query: 63 -WSPDGQCIATASDDFSVEIIH 83 WS G +A + D V + Sbjct: 313 SWSLSGNVLAISGGDNKVTLWK 334 >3JRO-A nrPDB Length = 753 Score = 112 bits (279), Expect = 2e-25, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 98/291 (33%), Gaps = 37/291 (12%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLS---YGLLHTFIGHTAPVISLTFN 105 + +H + G+ +AT S D +++I + + L+ T GH PV + + Sbjct: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 Query: 106 RK--GNLLFTSSMDESIKIWDTLNGSLMKT--ISAHSEAVVSVDV-PMNDSSILSSGSYD 160 G +L + S D + IW NG + + HS +V SV P +L S D Sbjct: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 Query: 161 GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE-------------NARYLLVK 207 G + + + + + D + ++ ++ +R + Sbjct: 123 GKVSVVEFKENGTTSPIIID------AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 176 Query: 208 SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD--FLNPEDGSTPLVISGYENGDI 265 D +VKIW Q LE + HS + +P + S ++ Sbjct: 177 GADNLVKIWKYNSDA-----QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 Query: 266 YCWNSDTKSLLQLLDGSLYHHSSPVM---SIHCFGNIMCSLALNGDCCLWR 313 W D + V+ S GN++ + LW+ Sbjct: 232 IIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 69.8 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 64/192 (33%), Gaps = 31/192 (16%) Query: 6 TPVGTQNGLKATC--AKISP---DGQFLAITQGLNILIYDINR-RTVSQTLVTSHARPFS 59 + + A+ + +P L + + + + T S ++ +HA + Sbjct: 90 SQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN 149 Query: 60 ELCWSP-------------DGQCIATASDDFSVEIIHLSYG-----LLHTFIGHTAPVIS 101 W+P + + T D V+I + L T GH+ V Sbjct: 150 SASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRD 209 Query: 102 LTFNRK---GNLLFTSSMDESIKIW--DTLNGSLMKTISAHSE--AVVSVDVPMNDSSIL 154 + ++ + L + S D + IW D G KT+ + V+ ++L Sbjct: 210 VAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVL 269 Query: 155 SSGSYDGLIRIF 166 + D + ++ Sbjct: 270 ALSGGDNKVTLW 281 >3BG0-A nrPDB Length = 316 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 105/293 (35%), Gaps = 29/293 (9%) Query: 45 TVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG---LLHTFIGHTAPVIS 101 +V T+ TSH + G +AT S D SV+I + G L+ GH PV Sbjct: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 Query: 102 LTFNR--KGNLLFTSSMDESIKIWDTLNGSLMKTIS--AHSEAVVSVDVPMND-SSILSS 156 + + GN+L + S D + IW NG+ K+ H +V SV +D IL+ Sbjct: 63 VAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILAC 122 Query: 157 GSYDGLIRI--------FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA----RYL 204 GS DG I + ++ + + T+ + V S + Sbjct: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRF 182 Query: 205 LVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL--VISGYEN 262 D ++K+W Q + +K H D P + S ++ Sbjct: 183 ASGGCDNLIKLW-----KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQD 237 Query: 263 GDIYCWNSDTKSLLQLLDGSLYHHSSPV--MSIHCFGNIMCSLALNGDCCLWR 313 G ++ W D S L+ + V +S NI+ + LW+ Sbjct: 238 GRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 Score = 49.8 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 18/110 (16%), Positives = 42/110 (38%), Gaps = 11/110 (10%) Query: 25 GQFLAITQGLNILIY--DINRRTVSQTLVTSHARPFSELCWSPD----GQCIATASDDFS 78 +F + I ++ + + + + + +H+ ++ W+P IA+ S D Sbjct: 180 KRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGR 239 Query: 79 VEIIHLSYGLLHTF-----IGHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 V I +T+ V ++++ N+L S D + +W Sbjct: 240 VFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 37.0 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 22/64 (34%), Gaps = 3/64 (4%) Query: 23 PDGQFLAITQGLNILIY---DINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSV 79 P + +Q + I+ D + T S L+ + WS +A + D V Sbjct: 227 PTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKV 286 Query: 80 EIIH 83 + Sbjct: 287 TLWK 290 >5WBU-D nrPDB Length = 328 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 45/325 (13%), Positives = 102/325 (31%), Gaps = 58/325 (17%) Query: 24 DGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII 82 D LA + + + ++T+ ++ + L +PD IA A + + Sbjct: 13 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQ-VNALEVTPDRSMIAAAGY-QHIRMY 70 Query: 83 HLSYGLLH---TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL--NGSLMKTISAH 137 L+ + ++ G + S+ F+ G ++T D + +IWD N + Sbjct: 71 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV- 129 Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ--- 194 + + V + N + ++ G G I I+D +T H + + + + P + Sbjct: 130 NAPINCVCLHPNQAELIV-GDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 188 Query: 195 ---------------------------------------VKFSENARYLLVKSLDGVVKI 215 +FS ++ L S D KI Sbjct: 189 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKI 248 Query: 216 WDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSL 275 W ++ ++ G D + +++ + W +T + Sbjct: 249 WRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD--SQYIVTASSDNLARLWCVETGEI 306 Query: 276 LQLLDGSLYHHSSPVMSIHCFGNIM 300 + H V+ + +++ Sbjct: 307 KR----EYGGHQKAVVCLAFNDSVL 327 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 36/251 (14%), Positives = 85/251 (33%), Gaps = 13/251 (5%) Query: 5 VTPVGTQNGLK--ATCAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSEL 61 P+ + +G+ DG+++ I+D+ R + + P + + Sbjct: 77 PNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCV 136 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGH-TAPVISLTFNRKGNLLFTSSMDESI 120 C P+ + ++ I L I + S + + + + + Sbjct: 137 CLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNC 196 Query: 121 KIWDTLNGS--------LMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 +W+ G I AH+ + DS++L++ S D +I+ Sbjct: 197 YVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRTSNFS 255 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 232 + L+ E+ + FS +++Y++ S D + ++W G + R + Sbjct: 256 LMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQK 315 Query: 233 EKGVLHHSCGM 243 L + + Sbjct: 316 AVVCLAFNDSV 326 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 93/259 (35%), Gaps = 32/259 (12%) Query: 66 DGQCIATASDDFSVEIIHLSYGLLHTFIGH-TAPVISLTFNRKGNLLFTSSMDESIKIWD 124 D +ATA D +V G+ + H + V +L +++ + + I+++D Sbjct: 13 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMYD 71 Query: 125 TLNGSLMKTIS--AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG--HCLKTLTYD 180 + + IS ++ + SV D + +G D RI+D + C + + Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGFH-EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 130 Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS 240 PI+ V N L+V G + IWD Q+ P + + + Sbjct: 131 ---------APINCVCLHPNQAELIVGDQSGAIHIWDLKTD---HNEQLIPEPEVSITSA 178 Query: 241 CGMDFLNPEDGSTPLVISGYENGDIYCWNSDTK---SLLQLLDGS-LYHHSSPVM--SIH 294 D + + G+ Y WN + QL+ + + H+ + Sbjct: 179 HI-------DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 231 Query: 295 CFGNIMCSLALNGDCCLWR 313 ++ + + + C +WR Sbjct: 232 PDSTLLATCSADQTCKIWR 250 >5MWJ-A nrPDB Length = 337 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 50/314 (15%), Positives = 105/314 (33%), Gaps = 32/314 (10%) Query: 7 PVGTQNGLKATC-AKISPDGQFLAITQGLNILIYDI----NRRTVSQTLVTSHARPFSEL 61 + T N + C IS + + + ++DI N+ VSQ + Sbjct: 44 QINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSC 103 Query: 62 CWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTA---PVISLTFNRKGNLLFTSSMDE 118 PDG + + ++ I L+ T+ +L + + F+ D Sbjct: 104 KLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDG 163 Query: 119 SIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLT 178 +I +WD N +L++ H++ +D+ ND + L +G D +R +D G L+ Sbjct: 164 NIAVWDLHNQTLVRQFQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREGRQLQ--- 219 Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLH 238 + + I + + +L V V++ + LH Sbjct: 220 ------QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQL---------HLH 264 Query: 239 HSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN 298 SC + G +S ++ + W + + + S S I Sbjct: 265 ESCVLSLKFAYCG--KWFVSTGKDNLLNAWRTPYGA---SIFQSKESSSVLSCDISVDDK 319 Query: 299 IMCSLALNGDCCLW 312 + + + + ++ Sbjct: 320 YIVTGSGDKKATVY 333 Score = 98.3 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 39/153 (25%), Positives = 70/153 (45%), Gaps = 3/153 (1%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 A+C IS DG L T GL+ + + R Q L + P G+ +A + Sbjct: 186 ASCIDISNDGTKL-WTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGME 244 Query: 76 DFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 +VE++H++ + H + V+SL F G ++ D + W T G+ + S Sbjct: 245 SSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIF-QS 303 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 S +V+S D+ ++D I+ +GS D +++ Sbjct: 304 KESSSVLSCDISVDDKYIV-TGSGDKKATVYEV 335 Score = 78.3 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 42/270 (15%), Positives = 82/270 (30%), Gaps = 36/270 (13%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGH------TAPVISLTFNRK 107 H + S + + T V++ +S+ + + + S Sbjct: 50 HGEVVCAVTISNPTRHVYTGGKGC-VKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPD 108 Query: 108 GNLLFTSSMDESIKIWDT--LNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRI 165 G L ++ IWD + +++ + A ++ + + S S DG I + Sbjct: 109 GCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCS-DGNIAV 167 Query: 166 FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR 225 +D ++ D S + S + L LD V+ WD G ++ Sbjct: 168 WDLHNQTLVRQFQGHTDGA--------SCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 219 Query: 226 TFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYH 285 H F + + G E+ ++ + + Q L+ Sbjct: 220 Q-----------HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ-----LHL 263 Query: 286 HSSPVMS--IHCFGNIMCSLALNGDCCLWR 313 H S V+S G S + WR Sbjct: 264 HESCVLSLKFAYCGKWFVSTGKDNLLNAWR 293 >4BH6-A nrPDB Length = 308 Score = 111 bits (276), Expect = 5e-25, Method: Composition-based stats. Identities = 53/303 (17%), Positives = 110/303 (36%), Gaps = 30/303 (9%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 + S LA+ G +I + D N V + ++ L W G +A Sbjct: 26 YSLIDWS-STDVLAVALGKSIFLTDNNTGDVVH--LCDTENEYTSLSWIGAGSHLAVGQA 82 Query: 76 DFSVEIIHL-SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK-T 133 + VEI + + T GH V L++N ++L + S D I D T Sbjct: 83 NGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRDHRILHRDVRMPDPFFET 140 Query: 134 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 193 I +H++ V + + D + L+SG D ++ +++ + + T K + Sbjct: 141 IESHTQEVCGLKWNVAD-NKLASGGNDNVVHVYEGTSKSPILTFDEHK--------AAVK 191 Query: 194 QVKFSENARYLLV---KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 + +S + R +L + D +KIW+ + ++ + + Sbjct: 192 AMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSH- 250 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 GY ++ W+ ++ + +L G + +++ G + S A + Sbjct: 251 --------GYSKYNLTLWDCNSMDPIAILKG--HSFRVLHLTLSNDGTTVVSGAGDETLR 300 Query: 311 LWR 313 W+ Sbjct: 301 YWK 303 Score = 96.4 bits (238), Expect = 1e-20, Method: Composition-based stats. Identities = 51/261 (19%), Positives = 99/261 (37%), Gaps = 29/261 (11%) Query: 15 KATCAKISPDGQFLAITQGLN-ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 + T G LA+ Q + IYD+ +R +TL + H + L W + + + Sbjct: 64 EYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTL-SGHIDRVACLSW--NNHVLTSG 120 Query: 74 SDDFSV--EIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 131 S D + + + T HT V L +N N L + D + +++ + S + Sbjct: 121 SRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPI 180 Query: 132 KTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETGHCLKTLTYDKDWKRENGV 189 T H AV ++ + +L++ G+ D ++I++ T + + + Sbjct: 181 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI---------DSG 231 Query: 190 VPISQVKFSENARYLLV--KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLN 247 I + +S+N L+ + +WDC + + L S Sbjct: 232 SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS------- 284 Query: 248 PEDGSTPLVISGYENGDIYCW 268 DG+T V+SG + + W Sbjct: 285 -NDGTT--VVSGAGDETLRYW 302 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 35/209 (16%), Positives = 68/209 (32%), Gaps = 49/209 (23%) Query: 8 VGTQNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD 66 + T +G A +S + L ++ IL D+ + SH + L W+ Sbjct: 97 IRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVA 156 Query: 67 GQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGN-LLFTSS--MDESIKI 122 +A+ +D V + + + TF H A V ++ ++ +L T D +KI Sbjct: 157 DNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKI 216 Query: 123 WDTLNG-------------------------------------------SLMKTISAHSE 139 W+ + + HS Sbjct: 217 WNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSF 276 Query: 140 AVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 V+ + + ND + + SG+ D +R + Sbjct: 277 RVLHLTLS-NDGTTVVSGAGDETLRYWKL 304 >4A11-B nrPDB Length = 408 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 53/334 (15%), Positives = 114/334 (34%), Gaps = 35/334 (10%) Query: 8 VGTQNGLKATCAKISP-DGQF-LAITQGLNILIYDINR------RTVSQTLVTS------ 53 V +G I P +G++ L+ I++YD+ T Sbjct: 38 VERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDV 97 Query: 54 HARPFSELCWSP-DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGN--- 109 H + W P D ++S D ++++ + V S + Sbjct: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 Query: 110 LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 L+ + +++ D +GS + H + +++V IL++ S D ++++D Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 Query: 170 TGH-CLKTLTYDKDWKRE-------NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 CL TL K + ++ + F+ + +LL D +++W+ G Sbjct: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 Query: 222 CVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDG 281 + K + G+ F S+ V Y + I + + + +L G Sbjct: 278 EN----TLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS-TIAVYTVYSGEQITMLKG 332 Query: 282 SLYHHSSPVMSIHCFGNIMCSLALNGDCCLWRWV 315 ++ + + S + + C + WV Sbjct: 333 --HYKTVDCCVFQSNFQELYSGSRD--CNILAWV 362 Score = 27.4 bits (59), Expect = 7.3, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 33/98 (33%), Gaps = 12/98 (12%) Query: 227 FQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSL----------- 275 ++ H G++ L+ E ++SG +G I ++ + S Sbjct: 30 LELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCS 89 Query: 276 LQLLDGSLYHHSSPVMSIHCFGN-IMCSLALNGDCCLW 312 + ++ +S + + + S + + +W Sbjct: 90 IGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVW 127 >5N4A-A nrPDB Length = 771 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 88/234 (37%), Gaps = 28/234 (11%) Query: 25 GQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP---------DGQCIATASD 75 + + I +++ Q + T A F+++ W P A A Sbjct: 26 NELFTCSDDQTIHKWNM-LGEPEQKVSTLDA-YFTDMHWYPVSSKKTQAGGTDVFAVACT 83 Query: 76 DFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 D SV+I+ + + + GH ISL ++ G L T+ D S+KIW NG L T++ Sbjct: 84 DGSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWS-RNGMLRSTLA 142 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKD---WKRENGVVPI 192 V S+ +YD + + +K+L+ + WK +GV + Sbjct: 143 QADSPVYSIVW-----------AYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGV--V 189 Query: 193 SQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 246 +V +S ++ D K+WD G + ++ V G F Sbjct: 190 LKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAWAPSGELFA 243 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 93/271 (34%), Gaps = 35/271 (12%) Query: 45 TVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIH--------LSYGLLHTFIGHT 96 V Q+ H+ + + W+ + + T SDD ++ + +S + H Sbjct: 4 KVKQSSANVHSELTAAVGWNVWNE-LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHW 62 Query: 97 APVISLTFNRKG-NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILS 155 PV S G ++ + D S+KI + G + K+I H A +S+ D + L+ Sbjct: 63 YPVSSKKTQAGGTDVFAVACTDGSVKI-LSRTGRVEKSIEGHKGACISLRWSY-DGTALA 120 Query: 156 SGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 + DG ++I+ G TL P+ + ++ + L + VV Sbjct: 121 TAGEDGSVKIWS-RNGMLRSTL--------AQADSPVYSIVWAYDCDQLCYCTGSNVV-- 169 Query: 216 WDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSL 275 + H + L+I+G E+ W+S + L Sbjct: 170 -------IKSLSSNAKQNAWKAHDGVVLKVDWSPIN--HLIITGGEDCKYKVWDSFGRLL 220 Query: 276 LQLLDGSLYHHSSPVMSIHCFGNIMCSLALN 306 Q L+ + ++ G + N Sbjct: 221 FQ---SGLFDYPVTSVAWAPSGELFAVGGFN 248 Score = 60.2 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 23/143 (16%), Positives = 51/143 (35%), Gaps = 2/143 (1%) Query: 11 QNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI 70 Q + D L G N++I ++ Q +H ++ WSP I Sbjct: 143 QADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSS-NAKQNAWKAHDGVVLKVDWSPINHLI 201 Query: 71 ATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL 130 T +D ++ LL PV S+ + G L ++++ D + + Sbjct: 202 ITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAWAPSGELFAVGGF-NTLQLCDRMGWAY 260 Query: 131 MKTISAHSEAVVSVDVPMNDSSI 153 K + +++++ + + + Sbjct: 261 SKIHLNDTGSIMTLSWTADSTQL 283 Score = 52.5 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 15/111 (13%), Positives = 37/111 (33%), Gaps = 9/111 (8%) Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENG 263 L S D + W+ +G + + + + + G T + +G Sbjct: 28 LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSK--KTQAGGTDVFAVACTDG 85 Query: 264 DIYCWNSDTKSLLQLLDGSLYHHSSPVMSI--HCFGNIMCSLALNGDCCLW 312 + + T + + ++G H +S+ G + + +G +W Sbjct: 86 SVKILSR-TGRVEKSIEG----HKGACISLRWSYDGTALATAGEDGSVKIW 131 >5WLC-LU nrPDB Length = 489 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 47/319 (14%), Positives = 104/319 (32%), Gaps = 53/319 (16%) Query: 25 GQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP-----------DGQCIATA 73 + + I ++++ R + +H + LC + + + Sbjct: 81 NKLATGSADGVIKYWNMSTREEFVSFK-AHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSC 139 Query: 74 SDDFSVEIIHLS------------------YGLLHTFIGHTAPVISLTFNRKGNLLFTSS 115 SDD +V++ ++ GL+ TF G + + +R+ + T Sbjct: 140 SDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDG-ESAFQGIDSHRENSTFATGG 198 Query: 116 MDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLK 175 I +WD + +S ++ + S+ N++ IL+S D I ++D T + Sbjct: 199 A--KIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQ 256 Query: 176 TLTYDKDWKRENGVVPISQVKFSE-NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEK 234 + + + ++ A + + D +D L Sbjct: 257 KIVQTMRT---------NAICWNPMEAFNFVTANEDHNAYYYDMRNLSR-------SLNV 300 Query: 235 GVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH 294 H S MD G +++G + I + ++ ++ H V Sbjct: 301 FKDHVSAVMDVDFSPTGDE--IVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQV-KYS 357 Query: 295 CFGNIMCSLALNGDCCLWR 313 + S + +G+ LWR Sbjct: 358 MDSKYIISGSDDGNVRLWR 376 Score = 87.1 bits (214), Expect = 8e-18, Method: Composition-based stats. Identities = 52/211 (24%), Positives = 93/211 (44%), Gaps = 24/211 (11%) Query: 5 VTPVGTQN--GLKATCAKIS-PDGQFLAITQGLN-ILIYDINRRTVSQTLVTSHARPFSE 60 + PV + T K + + LA T N I++YD+ + +Q +V + Sbjct: 209 LKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIV--QTMRTNA 266 Query: 61 LCWSPDGQC-IATASDDFSVEIIHLS--YGLLHTFIGHTAPVISLTFNRKGNLLFTSSMD 117 +CW+P TA++D + + L+ F H + V+ + F+ G+ + T S D Sbjct: 267 ICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYD 326 Query: 118 ESIKIWDTLNGSLMKTISAHSEA---VVSVDVPMNDSSILSSGSYDGLIRIF-------- 166 +SI+I+ T +G + H++ V V M DS + SGS DG +R++ Sbjct: 327 KSIRIYKTNHGHSREIY--HTKRMQHVFQVKYSM-DSKYIISGSDDGNVRLWRSKAWERS 383 Query: 167 DAETGHCLKTLTYDKDWK-RENGVVPISQVK 196 + +T L YD+ K R + I ++ Sbjct: 384 NVKTTREKNKLEYDEKLKERFRHMPEIKRIS 414 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 29/188 (15%), Positives = 61/188 (32%), Gaps = 16/188 (8%) Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 H + V ++ + L++GS DG+I+ ++ T + ++Q Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLC---VTQP 121 Query: 196 KFSENAR------YLLVKSLDGVVKIW----DCIGGCVVRTFQVQPLEKGVLHHSCGMDF 245 +F + ++L S D VK+W D E+G++ G Sbjct: 122 RFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESA 181 Query: 246 LNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHC-FGNIMCSLA 304 D I+ W+ + + L S + + + +I+ S Sbjct: 182 FQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDL--SWGADNITSLKFNQNETDILASTG 239 Query: 305 LNGDCCLW 312 + L+ Sbjct: 240 SDNSIVLY 247 >3JRP-A nrPDB Length = 379 Score = 104 bits (258), Expect = 6e-23, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 98/291 (33%), Gaps = 37/291 (12%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLS---YGLLHTFIGHTAPVISLTFN 105 + +H + G+ +AT S D +++I + + L+ T GH PV + + Sbjct: 5 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 64 Query: 106 RK--GNLLFTSSMDESIKIWDTLNGSLMKT--ISAHSEAVVSVDV-PMNDSSILSSGSYD 160 G +L + S D + IW NG + + HS +V SV P +L S D Sbjct: 65 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 124 Query: 161 GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE-------------NARYLLVK 207 G + + + + + D + ++ ++ +R + Sbjct: 125 GKVSVVEFKENGTTSPIIID------AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 178 Query: 208 SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD--FLNPEDGSTPLVISGYENGDI 265 D +VKIW Q LE + HS + +P + S ++ Sbjct: 179 GADNLVKIWKYNSDA-----QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 233 Query: 266 YCWNSDTKSLLQLLDGSLYHHSSPVM---SIHCFGNIMCSLALNGDCCLWR 313 W D + V+ S GN++ + LW+ Sbjct: 234 IIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 284 Score = 64.4 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 29/181 (16%), Positives = 60/181 (33%), Gaps = 29/181 (16%) Query: 15 KATCAKISP---DGQFLAITQGLNILIYDINR-RTVSQTLVTSHARPFSELCWSP----- 65 + +P L + + + + T S ++ +HA + W+P Sbjct: 103 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEE 162 Query: 66 --------DGQCIATASDDFSVEIIHLSYG-----LLHTFIGHTAPVISLTFNRK---GN 109 + + T D V+I + L T GH+ V + ++ + Sbjct: 163 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRS 222 Query: 110 LLFTSSMDESIKIW--DTLNGSLMKTISAHSE--AVVSVDVPMNDSSILSSGSYDGLIRI 165 L + S D + IW D G KT+ + V+ ++L+ D + + Sbjct: 223 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTL 282 Query: 166 F 166 + Sbjct: 283 W 283 >5WLC-LJ nrPDB Length = 513 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 45/272 (16%), Positives = 96/272 (35%), Gaps = 20/272 (7%) Query: 3 QFVTPVGTQNGLKATCAKISPDGQF-LAITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 Q+ + + T +P A+T + I+ R V +T Sbjct: 29 QYTSAQLVKEHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSR-FKDVVYSA 87 Query: 62 CWSPDGQCIATASDDFSVEIIHL--SYGLLHTFIGHTAPVISLTFN-RKGNLLFTSSMDE 118 + DG+ + V + +L + T P F+ + +L T+S D Sbjct: 88 SFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDR 147 Query: 119 SIKIWDTLN-GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTL 177 ++WD N ++ ++ V ++ ++++GSYDGLIR++D + Sbjct: 148 VTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRS------- 200 Query: 178 TYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVL 237 + N P+ V + + ++ K+WD + ++ K V Sbjct: 201 SGSTPIYSLNHDQPVENV-IAVSPTQIVSCGG-NNFKVWDLTSNKKL--YERGNFNKAV- 255 Query: 238 HHSCGMDFLNPEDGSTPLVISGYENGDIYCWN 269 +C N + +I+ +G + ++ Sbjct: 256 --TCLDYVENFDSPMQSALIASSLDGHVKVFD 285 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 24/193 (12%), Positives = 61/193 (31%), Gaps = 22/193 (11%) Query: 121 KIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYD 180 + W + + + H +V + + S ++IF + T +KT + Sbjct: 25 RYW--RQYTSAQLVKEH-NSVTHISFNPQHPHDFAVTS-STRVQIFSSRTRQVIKTFSRF 80 Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS 240 KD + F + + L G+V ++D + L H Sbjct: 81 KDV--------VYSASFRSDGKLLCAGDATGLVSVYDSYNPRTI------LLSINASTHP 126 Query: 241 CGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN-I 299 + + +D ++ + ++ W+ L+ + +S + Sbjct: 127 THVTKFHTQDN--KILATASDDRVTRLWDISNAY-EPQLELTGATDYVRTLSFIPAAPHL 183 Query: 300 MCSLALNGDCCLW 312 + + + +G L+ Sbjct: 184 VATGSYDGLIRLY 196 >4BZK-B nrPDB Length = 297 Score = 100 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 98/291 (33%), Gaps = 37/291 (12%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLS---YGLLHTFIGHTAPVISLTFN 105 + +H + G+ +AT S D +++I + + L+ T GH PV + + Sbjct: 3 VIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWA 62 Query: 106 RK--GNLLFTSSMDESIKIWDTLNGSLMKT--ISAHSEAVVSVDV-PMNDSSILSSGSYD 160 G +L + S D + IW NG + + HS +V SV P +L S D Sbjct: 63 HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD 122 Query: 161 GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE-------------NARYLLVK 207 G + + + + + D + ++ ++ +R + Sbjct: 123 GKVSVVEFKENGTTSPIIID------AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTG 176 Query: 208 SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD--FLNPEDGSTPLVISGYENGDI 265 D +VKIW Q LE + HS + +P + S ++ Sbjct: 177 GADNLVKIWKYNSDA-----QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 Query: 266 YCWNSDTKSLLQLLDGSLYHHSSPVM---SIHCFGNIMCSLALNGDCCLWR 313 W D + V+ S GN++ + LW+ Sbjct: 232 IIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 62.1 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 28/166 (16%), Positives = 57/166 (34%), Gaps = 26/166 (15%) Query: 27 FLAITQGLNILIYDINR-RTVSQTLVTSHARPFSELCWSP-------------DGQCIAT 72 L + + + + T S ++ +HA + W+P + + T Sbjct: 116 LLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVT 175 Query: 73 ASDDFSVEIIHLSYG-----LLHTFIGHTAPVISLTFNRK---GNLLFTSSMDESIKIW- 123 D V+I + L T GH+ V + ++ + L + S D + IW Sbjct: 176 GGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 Query: 124 -DTLNGSLMKTISAHSE--AVVSVDVPMNDSSILSSGSYDGLIRIF 166 D G KT+ + V+ ++L+ D + ++ Sbjct: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 52.5 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 19/112 (16%), Positives = 39/112 (34%), Gaps = 12/112 (10%) Query: 24 DGQFLAITQGLNILIYDINRRT---VSQTLVTSHARPFSELCWSPDG---QCIATASDDF 77 +F+ + I+ N V ++ + H+ ++ WSP +A+ S D Sbjct: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 229 Query: 78 SVEIIHLSYGL------LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 + I L + +++ GN+L S D + +W Sbjct: 230 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 >6ELZ-p nrPDB Length = 460 Score = 98.3 bits (243), Expect = 3e-21, Method: Composition-based stats. Identities = 60/316 (18%), Positives = 100/316 (31%), Gaps = 73/316 (23%) Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS 114 S L + I + S D V LS + + GH+ P+ ++ + L ++ Sbjct: 103 EDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQYSGHSGPIRAVKYI-SNTRLVSA 161 Query: 115 SMDESIKIWDTLN-----------------------GSLMKTISAHSEAVVSVDVPMNDS 151 D ++++W T N G + + H VVS+DV N Sbjct: 162 GNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVSDNSR 221 Query: 152 SILSSGSYDGLIRIF--------------DAET--------GHCLKTLTYDKDWKR---- 185 + S SYD I + D + LT R Sbjct: 222 --ILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAP 279 Query: 186 ----ENGVVPISQVKF-SENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS 240 E+ P+ QV F S + S D +K WD + + T + Sbjct: 280 LSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDT------------RT 327 Query: 241 CGMDFLNPEDGST-PLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH--CFG 297 L+ ST L+ G I + + ++ L H + V S+ Sbjct: 328 TSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPEN 387 Query: 298 N-IMCSLALNGDCCLW 312 I+CS + +G +W Sbjct: 388 EYILCSGSHDGTVKVW 403 Score = 94.8 bits (234), Expect = 4e-20, Method: Composition-based stats. Identities = 39/178 (21%), Positives = 75/178 (42%), Gaps = 6/178 (3%) Query: 43 RRTVSQTLVTSHARPFSELCW-SPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVIS 101 RR +L+ SH P ++ + S D + S D +++ L + ++S Sbjct: 275 RRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLS 334 Query: 102 LTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT----ISAHSEAVVSVDVPMNDSSILSSG 157 + NLL S I + D G+ K + H V S+D + IL SG Sbjct: 335 IAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSG 394 Query: 158 SYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 S+DG ++++D + + T+T + ++ + VK++E ++ D ++I Sbjct: 395 SHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVG-IISAGQDKKIQI 451 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 47/355 (13%), Positives = 110/355 (30%), Gaps = 85/355 (23%) Query: 24 DGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIH 83 ++ + + +D++ Q + H+ P + + + + + +A +D ++ + Sbjct: 115 SKHIISGSYDGIVRTWDLS--GNVQKQYSGHSGPIRAVKYISNTR-LVSAGNDRTLRLWK 171 Query: 84 LSYGLLH------------------------TFIGHTAPVISLTFNRKGNLLFTSSMDES 119 L GH APV+S+ + +L ++S D S Sbjct: 172 TKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVSDNSRIL-SASYDNS 230 Query: 120 IKIWDT--------------------------------------LNGSLMKTISAHSEAV 141 I W T + + + +H+ V Sbjct: 231 IGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPV 290 Query: 142 VSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA 201 V D+++ S S D I+ +D T C+ T T + ++ Sbjct: 291 EQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLN-------- 342 Query: 202 RYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE 261 L S + + D G + Q + ++ H + L+ + ++ SG Sbjct: 343 -LLACGSSARHITLHDPRVGASSKVTQ-----QQLIGHKNFVSSLDTCPENEYILCSGSH 396 Query: 262 NGDIYCWNSDTKSLLQLLDGSL----YHHSSPVMSIHCFGNI-MCSLALNGDCCL 311 +G + W+ + S + + + V ++ + + S + + Sbjct: 397 DGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVGIISAGQDKKIQI 451 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 53/150 (35%), Gaps = 40/150 (26%) Query: 187 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 246 + +S + + +++++ S DG+V+ WD G ++K HS + + Sbjct: 101 SNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSG----------NVQKQYSGHSGPIRAV 150 Query: 247 NPEDGSTPLVISGYENGDIYCW-----------------------NSDTKSLLQLLDGSL 283 S ++S + + W N + L +L+G Sbjct: 151 KYI--SNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEG-- 206 Query: 284 YHHSSPVMSIH-CFGNIMCSLALNGDCCLW 312 H +PV+SI + + S + + W Sbjct: 207 --HKAPVVSIDVSDNSRILSASYDNSIGFW 234 >4OWR-A nrPDB Length = 339 Score = 97.5 bits (241), Expect = 7e-21, Method: Composition-based stats. Identities = 45/290 (15%), Positives = 87/290 (30%), Gaps = 58/290 (20%) Query: 18 CAKISP----DGQFLAITQGLNILIYDI-NRRTVSQTLVTSHARPFSELCWSPDGQCIAT 72 C SP +A + ++ +++ + H P ++CWS DG + T Sbjct: 15 CLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFT 74 Query: 73 ASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNL--LFTSSMDESIKIWDTLNGSL 130 AS D + ++ LS H APV ++ + + N + T S D+++K WDT + + Sbjct: 75 ASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNP 134 Query: 131 MKTISA-------------------------------------------HSEAVVSVDVP 147 M + H V++ Sbjct: 135 MMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKD 194 Query: 148 MNDSSI-LSSGSYDGLIRIFDAETGHCLK---TLTYDKDWKRENG----VVPISQVKFSE 199 + + GS +G + I + K T + + ++ + F Sbjct: 195 KQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHP 254 Query: 200 NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPE 249 L DG WD ++T + + + Sbjct: 255 VHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYA 304 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 46/130 (35%), Gaps = 20/130 (15%) Query: 190 VPISQVKFSEN---ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 246 I + FS +L+ S V+ W+ + Q P + +H +D Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQD-----SGQTIPKAQQ-MHTGPVLDVC 64 Query: 247 NPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH----CFGNIMCS 302 +DGS V + + W+ + +Q+ H +PV +IH + + + Sbjct: 65 WSDDGSK--VFTASCDKTAKMWDLSSNQAIQI-----AQHDAPVKTIHWIKAPNYSCVMT 117 Query: 303 LALNGDCCLW 312 + + W Sbjct: 118 GSWDKTLKFW 127 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 18/86 (20%), Positives = 31/86 (36%), Gaps = 1/86 (1%) Query: 75 DDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 134 D+F+ + H S G + V + F+ L T D WD + +KT Sbjct: 224 DNFTFKC-HRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTS 282 Query: 135 SAHSEAVVSVDVPMNDSSILSSGSYD 160 + + + N + + SYD Sbjct: 283 EQLDQPISACCFNHNGNIFAYASSYD 308 >6CHG-D nrPDB Length = 439 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 61/333 (18%), Positives = 122/333 (36%), Gaps = 34/333 (10%) Query: 11 QNGLKATCAKISPDGQFLAI-TQGLNILIYDINRRTVSQ---TLVTSHARPFSELCWSPD 66 + + A C K SP G +LA+ I+IYD++ T +H R +CWS D Sbjct: 25 EVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSND 84 Query: 67 GQCIATASDDFSVEIIHL--SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 G+ + ++ D+ ++ + + P+ S R + T + + + Sbjct: 85 GRYLWSSGRDWYAKLWDMTQPTKCFQQYK-FDGPLWSCHVVRWNVCIVTVVEEPTAYVLT 143 Query: 125 TLNGSLM----------KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF--DAETGH 172 + + IS H +V+ P +S I+ +G+ G I F D E+G Sbjct: 144 LTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIES-IIITGTSKGWINAFQLDLESGF 202 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI--------GGCVV 224 K ++ I Q+ S + + + D ++ + I G Sbjct: 203 EDKIRCCYEEKIANAN---IKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHS 259 Query: 225 RTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS--GYENGDIYCWNSDTKSLLQLLDGS 282 + +++ + +++ LV S G D+Y W + + SL+++L+G+ Sbjct: 260 VSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLEGA 319 Query: 283 LYHHSSPVMSIHCFGNIMCSLALNGDCCLWRWV 315 + I + +G +W V Sbjct: 320 DEELLDIDWNF-YSMRIASNGFESGWVYMWSIV 351 >3W15-A nrPDB Length = 368 Score = 95.6 bits (236), Expect = 2e-20, Method: Composition-based stats. Identities = 47/293 (16%), Positives = 97/293 (33%), Gaps = 45/293 (15%) Query: 22 SPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQC-IATASDDFSVE 80 S + Q L + ++D + + H R W+ + ++S D S++ Sbjct: 73 SHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIK 132 Query: 81 IIHLSYGL-------------------------LHTFIG---HTAPVISLTFNR-KGNLL 111 I +F G + V F+ NL+ Sbjct: 133 IWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLV 192 Query: 112 FTSSMDESIKIWDTL--NGSLMKTISAHSE-AVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 + S + ++D +G HS ++ D ++++G D IRI+D Sbjct: 193 LSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI 252 Query: 169 ETGHCLKTLTYDK---DWKRENGVVPISQVKFSENARYLL-VKSLDGVVKIW-DCIGGCV 223 + ++ + + I +V +S + +L S D +IW D Sbjct: 253 RMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGA 312 Query: 224 VRTFQVQPL---EKGVLHHSCGMDFLNPEDGST----PLVISGYENGDIYCWN 269 T++ + + + + +F+ D S V S +G+++ WN Sbjct: 313 KETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 71.7 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 44/270 (16%), Positives = 87/270 (32%), Gaps = 44/270 (16%) Query: 76 DFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKG-NLLFTSSMDESIKIWDTLNGS-LMKT 133 D S I+ ++ L + L +N N + + D +++++DT + Sbjct: 48 DRSGRIVEVNSFLTQD------CLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAI 101 Query: 134 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY-------------- 179 H V S + + + S S+DG I+I+ L TLT Sbjct: 102 FKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNA 161 Query: 180 -----DKDWKRENGVVPISQVKFSE-NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 + Q +FS + +L S + ++D + Sbjct: 162 IILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPS------GKNQN 215 Query: 234 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDT--KSLLQL-----LDGSLYHH 286 ++H + +V +G + I W+ K+ QL ++ H Sbjct: 216 NFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAH 275 Query: 287 SSPVMSIH---CFGNIMCSLALNGDCCLWR 313 + + NI+ S + + C +WR Sbjct: 276 GLAIRKVTWSPHHSNILMSASYDMTCRIWR 305 Score = 69.4 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 47/273 (17%), Positives = 96/273 (35%), Gaps = 55/273 (20%) Query: 3 QFVTPVGTQNGLKATCAKIS--PDGQFLAITQGLNILIYD-------------------- 40 +F + ++ + + FL+ + +I I+ Sbjct: 96 EFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKM 155 Query: 41 ------INRRTVSQTLVTSHARPFSELCWSPDGQCIA-TASDDFSVEIIHL---SYGLLH 90 I + S T ++ + + +SP Q + + S + + + S + Sbjct: 156 VDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQN 215 Query: 91 TFIGHTA-PVISLTFNRKGNLLF-TSSMDESIKIWDTL----------NGSLMKTI-SAH 137 F+ H+ ++ FN+ + T +D +I+IWD N S + I +AH Sbjct: 216 NFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAH 275 Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIF-DAETGHCLKTLTYDKDWKREN-------GV 189 A+ V + S+IL S SYD RI+ D +T + + Sbjct: 276 GLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHS 335 Query: 190 VPISQVKFSENAR--YLLVKSLDGVVKIWDCIG 220 + +S + Y+ + DG + +W+ +G Sbjct: 336 EFVFGADWSLWGKPGYVASTAWDGNLFVWNGLG 368 >1NR0-A nrPDB Length = 611 Score = 95.2 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 34/161 (21%), Positives = 76/161 (47%), Gaps = 8/161 (4%) Query: 15 KATCAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 ++C +S D QF+A+ + +Y ++ +VS+ H + + +S +G + Sbjct: 450 NSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT 509 Query: 74 SDDFSVEIIHLSYGLL----HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 V ++ +++ HTA V ++++ L T S+D S+ +W+ S Sbjct: 510 DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPS 569 Query: 130 LMKTI--SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 I AH+ + V+ + +N+++I+S+G D I+ ++ Sbjct: 570 DHPIIIKGAHAMSSVNSVIWLNETTIVSAG-QDSNIKFWNV 609 Score = 95.2 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 49/297 (16%), Positives = 103/297 (34%), Gaps = 22/297 (7%) Query: 22 SPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEI 81 +P G + G ++ + T ++ + T H+ + SP G A+ +V I Sbjct: 27 TPAGDKIQYCNGTSVYTVPVGSLTDTE-IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRI 85 Query: 82 IHLSYG---LLHTFIGHTAPVISLTFNRKGNLLFTSSMDE----SIKIWDTLNGSLMKTI 134 + L T + PV ++++ + + + ++D G+ + Sbjct: 86 WDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFD--TGTSNGNL 143 Query: 135 SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ 194 + + A+ SVD + + SGS D + IF+ T + + Sbjct: 144 TGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKF--------VHS 195 Query: 195 VKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTP 254 V+++ + DG + +++ + G F+ L K V H DG+ Sbjct: 196 VRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL-KNVAHSGSVFGLTWSPDGTK- 253 Query: 255 LVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCL 311 + S + I WN T + + + + I + S++ NG Sbjct: 254 -IASASADKTIKIWNVATLKVEKTIPVGTRI-EDQQLGIIWTKQALVSISANGFINF 308 Score = 90.6 bits (223), Expect = 8e-19, Method: Composition-based stats. Identities = 48/256 (18%), Positives = 89/256 (34%), Gaps = 21/256 (8%) Query: 18 CAKISPDGQF--LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 P F ++ + + I++ T H + + ++PDG A+ Sbjct: 152 SVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTF-GEHTKFVHSVRYNPDGSLFASTGG 210 Query: 76 DFSVEIIHLSYGLLHTF--------IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 D ++ + + G + H+ V LT++ G + ++S D++IKIW+ Sbjct: 211 DGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT 270 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN 187 + KTI + + L S S +G I + E G + Sbjct: 271 LKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNK----- 325 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTF--QVQPLEKGVLHHSCGMDF 245 I+ + S + + L +G + WD G R F + G+ S G F Sbjct: 326 ---AITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLF 382 Query: 246 LNPEDGSTPLVISGYE 261 D +V +G Sbjct: 383 TVSWDDHLKVVPAGGS 398 Score = 87.1 bits (214), Expect = 8e-18, Method: Composition-based stats. Identities = 64/381 (16%), Positives = 115/381 (30%), Gaps = 98/381 (25%) Query: 18 CAKISPDGQFLAITQGL-NILIYDINRRTVSQTLVT------SHARPFSELCWSPDGQCI 70 + +PDG A T G I++Y+ T + +H+ L WSPDG I Sbjct: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 Query: 71 ATASDDFSVEIIHLSY-------------------------------------------G 87 A+AS D +++I +++ G Sbjct: 255 ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELG 314 Query: 88 LLHT-FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA-HSEAVVSVD 145 + GH + +L+ + G LF++ + I WD G + H+ + + Sbjct: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK 374 Query: 146 VPMNDSSILSSGSYDGLIRIF------------------------------DAETGHCLK 175 L + S+D +++ D C K Sbjct: 375 TTSKGD--LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 Query: 176 --TLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ-VQPL 232 + S V S + +++ V D V ++ G V V P Sbjct: 433 HIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPA 492 Query: 233 EKGVLHHSCGMDFLNPEDGSTPLV-ISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVM 291 E + S FL D S ++ S N ++ NS T + + Sbjct: 493 EITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWT----------FHTAKVACV 542 Query: 292 SIHCFGNIMCSLALNGDCCLW 312 S + + +L+ +W Sbjct: 543 SWSPDNVRLATGSLDNSVIVW 563 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 35/250 (14%), Positives = 80/250 (32%), Gaps = 23/250 (9%) Query: 25 GQFLAITQGLNILIYDINRRTVSQTLVTSH--ARPFSELCWSPDGQCIATASDDFSVEII 82 G ++ ++ + V + ++ + L S DG A Sbjct: 379 GDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAI-- 436 Query: 83 HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSL--MKTISAHSEA 140 S+G L T + + + + + D + ++ S+ +KTI H Sbjct: 437 -YSHGKL-TEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAE 493 Query: 141 VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN 200 + SV N + ++++ D ++ + L + W ++ V +S + Sbjct: 494 ITSVAFSNNGAFLVAT---DQSRKVIPYSVAN-NFELAHTNSW--TFHTAKVACVSWSPD 547 Query: 201 ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY 260 L SLD V +W+ ++ ++ ++S Sbjct: 548 NVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT--------IVSAG 599 Query: 261 ENGDIYCWNS 270 ++ +I WN Sbjct: 600 QDSNIKFWNV 609 Score = 29.0 bits (63), Expect = 2.8, Method: Composition-based stats. Identities = 8/46 (17%), Positives = 16/46 (34%) Query: 267 CWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + SL + + H + V G S ++G+ +W Sbjct: 41 VYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIW 86 >5WYJ-BE nrPDB Length = 939 Score = 94.4 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 39/224 (17%), Positives = 80/224 (35%), Gaps = 12/224 (5%) Query: 37 LIYDINRRTVSQ-TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHT-FIG 94 +D+ + V + T T+ + S G S + S+ I ++ G+L + Sbjct: 441 RTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKL 500 Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSIL 154 H V ++ + + + +D + +D +L+ + +A ++ V S + Sbjct: 501 HKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKL--DAPITAMVYHRSSDLF 558 Query: 155 SSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVK 214 + D I + DA T ++ L + I+ FS R+++ SLD ++ Sbjct: 559 ALALDDLSIVVIDAVTQRVVRQLWGHSNR--------ITAFDFSPEGRWIVSASLDSTIR 610 Query: 215 IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS 258 WD G + V + V G + I Sbjct: 611 TWDLPTGGCIDGIIVDNVATNVKFSPNGDLLATTHVTGNGICIW 654 Score = 80.6 bits (197), Expect = 7e-16, Method: Composition-based stats. Identities = 39/206 (18%), Positives = 80/206 (38%), Gaps = 12/206 (5%) Query: 12 NGLKATCAKISPDG---QFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQ 68 K IS DG + ++ + YD N+ T+ L P + + + Sbjct: 499 KLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLD--APITAMVYHRSSD 556 Query: 69 CIATASDDFSVEIIHLSYGLL-HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 A A DD S+ +I + GH+ + + F+ +G + ++S+D +I+ WD Sbjct: 557 LFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPT 616 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF-DAETGHCLKTLTYDKDWKRE 186 G + I +V N + ++ I I+ + + T T D+ Sbjct: 617 GGCIDGIIV-DNVATNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESEFAR 675 Query: 187 NGVVPISQVKFSENARYLLVKSLDGV 212 + P + V+ +++ +L +L+ Sbjct: 676 MAL-PSTSVRGNDS---MLSGALESN 697 Score = 78.6 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 44/249 (17%), Positives = 88/249 (35%), Gaps = 27/249 (10%) Query: 68 QCIATASDDFSVEIIHLSYGLLHTFIGHT---APVISLTFNRKGNLLFTSSMDESIKIWD 124 I D+ + + + T V S+ ++ GN F S + SI I++ Sbjct: 429 NIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYN 488 Query: 125 TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 +G L K H AV + + + ++S G DG++ +D L L D Sbjct: 489 MQSGILRKKYKLHKRAVTGISLDGMNRKMVSCG-LDGIVGFYDFNKSTLLGKLKLD---- 543 Query: 185 RENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD 244 PI+ + + ++ + D + + D + VVR S Sbjct: 544 -----APITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSP--- 595 Query: 245 FLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLA 304 ++S + I W+ T +DG + + + + G+++ + Sbjct: 596 -------EGRWIVSASLDSTIRTWDLPTGGC---IDGIIVDNVATNVKFSPNGDLLATTH 645 Query: 305 LNGD-CCLW 312 + G+ C+W Sbjct: 646 VTGNGICIW 654 Score = 61.3 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 45/285 (15%), Positives = 96/285 (33%), Gaps = 32/285 (11%) Query: 25 GQFL-AITQGLNILIY---DINRRTVSQ-----TLVTSHARPFSELCWSPDGQCIATASD 75 G +L A T +I IY D + S+ T+ L Q +AT + Sbjct: 125 GDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIVSL------QHLATYLN 178 Query: 76 DFSVE------IIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 128 +V + ++ G L T + + +++ ++ + +++ G Sbjct: 179 KLTVVTKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKG 238 Query: 129 SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENG 188 ++TI + S+ + SS LS G+ G + +D + + L Sbjct: 239 KRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVL----KNIHRES 294 Query: 189 VVPISQVKFSENARYLLVKSLDGVVK--IWD--CIGGCVVRTFQVQPLEKGVLHHSCGMD 244 ++Q F ++ D +K ++D G Q + HS Sbjct: 295 YGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPS 354 Query: 245 FLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSP 289 ++ D + ++S ++ + W+ + Q + S H Sbjct: 355 YIAFADSQSHFMLSASKDRSL--WSFSLRKDAQSQEMSQRLHKKQ 397 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 58/342 (16%), Positives = 112/342 (32%), Gaps = 52/342 (15%) Query: 9 GTQNGLKATCAKISPDGQFLA-ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG 67 + + T A+ +P +A T ++++++ + +T+ +R S L + DG Sbjct: 202 SNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIRTIKIPQSR-ISSLSFRTDG 260 Query: 68 QC---IATASDDFSVEIIHLSYGLLHTFIGHT---APVISLTFNRKGNLLFTSSMDESIK 121 + T+S D + + H V TF ++ TS D S+K Sbjct: 261 SSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLK 320 Query: 122 --IWD-----------TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF-- 166 ++D +++ HS+ + + S + S S D ++ Sbjct: 321 EYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRS--LWSF 378 Query: 167 ----DAETGHCLKTLTYDKDWKRENGVV------PISQVKFSENAR-----YLLVKSLD- 210 DA++ + L +D R G I + ENAR ++ D Sbjct: 379 SLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAI-ENARIGEWENIITAHKDE 437 Query: 211 GVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 + WD V + G+ + G NG I +N Sbjct: 438 KFARTWDMRNKRV------GRWTFDTTDDGFVKSVAMSQCGNFGFI--GSSNGSITIYNM 489 Query: 271 DTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + L + L+ + +S+ M S L+G + Sbjct: 490 QSGILRKKY--KLHKRAVTGISLDGMNRKMVSCGLDGIVGFY 529 >4E5Z-B nrPDB Length = 436 Score = 89.8 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 39/308 (12%), Positives = 101/308 (32%), Gaps = 29/308 (9%) Query: 15 KATCAKISPD--GQFLAITQGLNILIYDIN-RRTVSQTLVTSHARPFSELCWSP-DGQCI 70 +AT P ++G +I++++ + + + L ++P + Sbjct: 121 RATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQF 180 Query: 71 ATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTF-----NRKGNLLFTSSMDESIKIWDT 125 +S + + + +L F ++ I++ F + ++ T ++ + + Sbjct: 181 YASSMEGTTRLQDFKGNILRVFA--SSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM 238 Query: 126 LNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKR 185 G + + H + V V + L++ S D ++I+D + Y Sbjct: 239 D-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLY-----S 292 Query: 186 ENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF 245 P++ FS + LL ++++ P + H + Sbjct: 293 LPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP-HRHFQHLTPIKAA 351 Query: 246 LNP----------EDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHC 295 +P D + + YE I ++ ++ ++ L S + + Sbjct: 352 WHPRYNLIVVGRYPDPNFKS-CTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNP 410 Query: 296 FGNIMCSL 303 G+ + S Sbjct: 411 MGDTLASA 418 >3JZG-A nrPDB Length = 402 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 54/335 (16%), Positives = 116/335 (34%), Gaps = 50/335 (14%) Query: 24 DGQFLAITQGLNILIYDINRRTVSQTLVT----SHARPFSELCWSPDGQ----CIATASD 75 D A + +Y+ + + + L + F W+ D +A A Sbjct: 70 DPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS 129 Query: 76 DFSVEIIH-LSYGLLHTFIGHTAPVISLTFNR-KGNLLFTSSMDESIKIWDTLNGSLMKT 133 + II+ ++ + ++GH + L F+ NLL + S D ++++W+ +L+ Sbjct: 130 RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI 189 Query: 134 I---SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN--- 187 H + V+S D + I+S G D ++++ + + + D+ Sbjct: 190 FGGVEGHRDEVLSADYDLLGEKIMSCG-MDHSLKLWRINSKRMMNAIKESYDYNPNKTNR 248 Query: 188 -----------------GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ 230 + V++ +L KS + + W G +++ Sbjct: 249 PFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWK-PGKMEDDIDKIK 305 Query: 231 PLEKGVL----HHSCGMDFLNPE---DGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSL 283 P E V D D ++ G + G +Y W+ + + + +L Sbjct: 306 PSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTL 365 Query: 284 YHHS----SPVMSIHCFGNIMCSLALNGDCCLWRW 314 HH S +I+ ++ + +WRW Sbjct: 366 THHKCGAAIRQTSFSRDSSILIAVCDDAS--IWRW 398 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 35/291 (12%), Positives = 83/291 (28%), Gaps = 28/291 (9%) Query: 43 RRTVSQTLVTSHARPFSELCWSPDGQ-----CIATASDDFSVEIIHLSYGLLHTFIGHTA 97 +L H +P + ++ + AT + S G + + Sbjct: 42 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 101 Query: 98 P-----VISLTFNRKGN----LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPM 148 + + N LL + I+I + + +K H A+ + Sbjct: 102 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 161 Query: 149 NDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKS 208 D ++L S S D +R+++ +T + E + + ++ Sbjct: 162 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGG-----VEGHRDEVLSADYDLLGEKIMSCG 216 Query: 209 LDGVVKIWDCIGGCVVR------TFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN 262 +D +K+W ++ + + + + D V Sbjct: 217 MDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL 276 Query: 263 GDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALN-GDCCLW 312 GD+ S +++ G + + N+ + C +W Sbjct: 277 GDLILSKSCENAIVCWKPGKMEDDIDKIKP--SESNVTILGRFDYSQCDIW 325 Score = 54.4 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 40/251 (15%), Positives = 77/251 (30%), Gaps = 60/251 (23%) Query: 19 AKISPD--GQFLAITQGLNILIYDINRRTVSQTL--VTSHARPFSELCWSPDGQCIATAS 74 K P L++++ + +++I T+ V H + G+ I + Sbjct: 157 LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCG 216 Query: 75 DDFSVEIIHLSYGL-----------------------------LHTFIGHTAPVISLTFN 105 D S+++ ++ T H V + + Sbjct: 217 MDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW- 275 Query: 106 RKGNLLFTSSMDESIKIW---------DTLNGSLMKTISAHSEAVVSVDVPMND------ 150 G+L+ + S + +I W D + S D+ Sbjct: 276 -LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFW 334 Query: 151 SSILSSGSYDGLIRIFDAETGHCLK----TLTYDKDWKRENGVVPISQVKFSENARYLLV 206 +L+ G+ G + ++D E K TLT+ K I Q FS ++ L+ Sbjct: 335 QKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCG------AAIRQTSFSRDSSILIA 388 Query: 207 KSLDGVVKIWD 217 D + WD Sbjct: 389 VCDDASIWRWD 399 Score = 32.4 bits (72), Expect = 0.24, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 47/129 (36%), Gaps = 23/129 (17%) Query: 18 CAKISPDGQFLAITQGLNILIY-------DINRRTVSQTLVTSHARPFSELC------WS 64 C + D L+ + I+ + DI++ S++ VT R C +S Sbjct: 272 CVRWLGD-LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFS 330 Query: 65 PD--GQCIATASDDFSVEIIHLSYGLLH-----TFIGHT--APVISLTFNRKGNLLFTSS 115 D + +A + + + L H T H A + +F+R ++L Sbjct: 331 MDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC 390 Query: 116 MDESIKIWD 124 D SI WD Sbjct: 391 DDASIWRWD 399 >5CXC-A nrPDB Length = 510 Score = 89.0 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 105/286 (36%), Gaps = 48/286 (16%) Query: 65 PDGQCIATASDDFSVEIIHLSYGLLHT-----FIGHTAPVISLTFNRKGNLLFTSSMDES 119 P + + +AS D + I + S ++ T GHTA + + F + L ++ MD + Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKF-LTSDRLASAGMDRT 214 Query: 120 IKIW-----DTLNGSLMKTIS--AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE--- 169 +++W D G L T+ H+ +V +DV + IL + S DG I + A Sbjct: 215 VRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHIL-TASADGAIGFWSASKAS 273 Query: 170 --------------TGHCLKTLTYDKDWKRENGVVPISQVK-----FSENARYLL-VKSL 209 + T + + G+ I F R + S Sbjct: 274 APEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQ 333 Query: 210 DGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN 269 D V+ D G VV T + H + L ++PL+ +G I + Sbjct: 334 DHTVRTLDLTTGQVVSTL-------TLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVD 386 Query: 270 SDTKSLLQLLDGSLYHHSSPVMSIHCFGN---IMCSLALNGDCCLW 312 S + +L H++ V+S+ + S + +G C +W Sbjct: 387 PRASSATTSVM-TLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVW 431 Score = 77.9 bits (190), Expect = 6e-15, Method: Composition-based stats. Identities = 48/305 (15%), Positives = 93/305 (30%), Gaps = 51/305 (16%) Query: 26 QFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL--CWSPDGQCIATASDDFSVEIIH 83 + L+ + + I++ + ++ + SH + + +A+A D +V + Sbjct: 160 RVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWK 219 Query: 84 LS-----YGLLH---TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS------ 129 + G L GHT V L + + T+S D +I W S Sbjct: 220 YTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDA 279 Query: 130 ------------------------LMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRI 165 + S H+ + D ++ S S D +R Sbjct: 280 SLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRT 339 Query: 166 FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR 225 D TG + TLT + + + + L + + + D Sbjct: 340 LDLTTGQVVSTLTLTHPLLSLSALT-----RAGTTSPLLAAGTSARHITMVDPRASSATT 394 Query: 226 TFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYH 285 + + L+P + ++SG +G W+ + +GSL Sbjct: 395 SVMTLRGHANKVV------SLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGG 448 Query: 286 HSSPV 290 S PV Sbjct: 449 VSEPV 453 Score = 68.2 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 43/179 (24%), Positives = 74/179 (41%), Gaps = 14/179 (7%) Query: 54 HARPFSELCWSPDGQCIA-TASDDFSVEIIHLSYGLLHTFIGHTAPVISL-TFNRKGN-- 109 H P + + P + +A +AS D +V + L+ G + + + T P++SL R G Sbjct: 311 HTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTS 370 Query: 110 -LLFTSSMDESIKIWDTLNGSL---MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRI 165 LL + I + D S + T+ H+ VVS+ + L SGS+DG R+ Sbjct: 371 PLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRV 430 Query: 166 FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVK----IWDCIG 220 +D + E V I + ++ + + DG K +WD +G Sbjct: 431 WDLRSVRPATKEEGSLGGVSEP-VYVIERESWASKGKKKRPVAGDG-CKVFSVVWDKLG 487 Score = 55.5 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 31/132 (23%), Positives = 55/132 (41%), Gaps = 18/132 (13%) Query: 148 MNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK 207 + S SYDGL+RI++A +G + T I KF + R L Sbjct: 155 QPGQERVLSASYDGLLRIWNA-SGSVIAT---SPSGSHGGHTASIKAAKFLTSDR-LASA 209 Query: 208 SLDGVVKIW-----DCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN 262 +D V++W D G + T ++ H+ +D+L+ DG + +++ + Sbjct: 210 GMDRTVRVWKYTESDHFTGELKPTLELY-------GHTGSVDWLDV-DGHSKHILTASAD 261 Query: 263 GDIYCWNSDTKS 274 G I W++ S Sbjct: 262 GAIGFWSASKAS 273 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 10/66 (15%), Positives = 26/66 (39%), Gaps = 1/66 (1%) Query: 250 DGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHC-FGNIMCSLALNGD 308 V+S +G + WN+ + GS H++ + + + + S ++ Sbjct: 155 QPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRT 214 Query: 309 CCLWRW 314 +W++ Sbjct: 215 VRVWKY 220 >4G56-B nrPDB Length = 357 Score = 89.0 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 46/258 (17%), Positives = 92/258 (35%), Gaps = 23/258 (8%) Query: 31 TQGLNILIYDINRRTVSQTLVTS---HARPFSELCWSPDGQCIATASDDFSVEIIHL--- 84 T G +I ++ +++L T+ +++ W + + ASD +VE+ + Sbjct: 67 TWGGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKGILV-ASDSGAVELWEILEK 125 Query: 85 SYGLLHTF--IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVV 142 L++ F H V +L+ G + D S+K+WD +++K+ +AHS V Sbjct: 126 ESLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVN 185 Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR 202 V +I S DG I ++D + + + V + Sbjct: 186 CVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIP------TSVTWHPEKD 239 Query: 203 YLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN 262 D G + + + HS + L S+P + S E+ Sbjct: 240 DTFACG--------DETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISED 291 Query: 263 GDIYCWNSDTKSLLQLLD 280 + ++D + + L Sbjct: 292 CTVAVLDADFSEVFRDLS 309 Score = 68.2 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 28/203 (13%), Positives = 77/203 (37%), Gaps = 16/203 (7%) Query: 17 TCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP-DGQCIATASD 75 T + S Q ++ + ++ ++D++++ V ++ +H+ + + P + + Sbjct: 144 TLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYN-AHSSEVNCVAACPGKDTIFLSCGE 202 Query: 76 DFSVEIIHLSYGLLHTFIGH--TAPV-ISLTFNRK-GNLLFTSSMDESIKIWDTLNGSLM 131 D + + T I + + S+T++ + + ++ + + N Sbjct: 203 DGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSA 262 Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 191 +T + HS+ + + + S L+S S D + + DA+ + L+ Sbjct: 263 QTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS---------HRDF 313 Query: 192 ISQVKFSE-NARYLLVKSLDGVV 213 ++ V +S + D V Sbjct: 314 VTGVAWSPLDHSKFTTVGWDHKV 336 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 24/175 (13%), Positives = 55/175 (31%), Gaps = 16/175 (9%) Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 V V +++S S G + +++ L + + + + Sbjct: 94 EAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLV----NKFAKYEHDDIVKTLSV 147 Query: 198 SENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVI 257 + + D VK+WD V++++ HS ++ + G + + Sbjct: 148 FSDGTQAVSGGKDFSVKVWDLSQKAVLKSYN---------AHSSEVNCVAACPGKDTIFL 198 Query: 258 SGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF-GNIMCSLALNGDCCL 311 S E+G I W++ +D ++ H + G+ L Sbjct: 199 SCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSL 253 >4XFV-A nrPDB Length = 792 Score = 87.9 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 56/364 (15%), Positives = 118/364 (32%), Gaps = 57/364 (15%) Query: 9 GTQNGLKA--TCAKISPDGQF-LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP 65 T G +A TC + PD F ++ ++ ++ I+ + Q + T + + S Sbjct: 57 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA 116 Query: 66 DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPV-------ISLTFNR---KGNLLFTSS 115 I+ D ++ I + + H + + L+ ++ K LL Sbjct: 117 LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 176 Query: 116 MDESIKIWD-------TLNGSLMKTISAHSEAVVSVDV---PMNDSSILSSGSYDGLIRI 165 + ++ I ++ + H + V S+ +L SGS D IR+ Sbjct: 177 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 236 Query: 166 FDAETGHCLK---------TLTYDKDWKRE----------------NGVVPISQVKFSEN 200 + + TL +K +K + IS +++ E+ Sbjct: 237 WRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHES 296 Query: 201 ARYLLVKSLDGVVKIW--DCIGGCVVRTFQVQPLEKGVLHHSCGMD-----FLNPEDGST 253 LL + D + +W D G V + ++ + + G L Sbjct: 297 RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERM 356 Query: 254 PLVISGYENGDIYCWNSDTKS-LLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 ++ + G W + Q L S ++ G + + +L+ L+ Sbjct: 357 DFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 416 Query: 313 R-WV 315 W+ Sbjct: 417 APWI 420 Score = 84.0 bits (206), Expect = 8e-17, Method: Composition-based stats. Identities = 43/223 (19%), Positives = 83/223 (37%), Gaps = 22/223 (9%) Query: 68 QCIATASDDFSVEIIHL----SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW 123 + I ++ + + G+ T GH A V + F + + ++S D +KIW Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Query: 124 ---DTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYD 180 D + ++TI +S+ +V++ S++S G DG I I+ + L ++ Sbjct: 91 KFTDYSHLQCIQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQNIQNDEFGLAHE 147 Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW-------DCIGGCVVRTFQVQPLE 233 K+ + E +YLL V ++ D +++ E Sbjct: 148 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN-VNVFIASFILSDSGIEKCRVVAELEGHE 206 Query: 234 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLL 276 V + F + E L+ SG ++ I W L+ Sbjct: 207 DWVK----SLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 245 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 41/229 (17%), Positives = 87/229 (37%), Gaps = 22/229 (9%) Query: 13 GLKATCAKISPDGQFLAITQGLN------ILIYDINRRTVSQTLVTSHARPFSELCWSPD 66 G + TC ISPD + +A N I I+ + + H+ + L +S D Sbjct: 562 GFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKD 621 Query: 67 GQCIATASDDFSVEIIHLSYG------LLHTFIGHTAPVISLTFNRK--GNLLFTSSMDE 118 G+ + + D + + HT + + GN+ T+S D+ Sbjct: 622 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 681 Query: 119 SIKIW----DTLNGSLMKTISAHSEAVVSVDVPM---NDSSILSSGSYDGLIRIFDAETG 171 ++K+W + + +++ H++AV ++ + + ++S G +G I ++ G Sbjct: 682 TVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLG 741 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLL-VKSLDGVVKIWDCI 219 ++D + + + N + L V S D +I+ Sbjct: 742 KFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLA 790 Score = 72.9 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 30/240 (12%), Positives = 71/240 (29%), Gaps = 16/240 (6%) Query: 45 TVSQTLVTSHARPFSELCWSPDGQCIATAS-----DDFSVEIIHLSY--GLLHTFIGHTA 97 + H + L SPD + IA+A + + I + H+ Sbjct: 552 WPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSL 611 Query: 98 PVISLTFNRKGNLLFTSSMDESIKIW--DTLNGSLMKTISA---HSEAVVSVDVPMND-S 151 + L F++ G L + D +W + + + H+ + D + Sbjct: 612 TITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG 671 Query: 152 SILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKS-LD 210 ++ + S D ++++ + + K V IS + L+ + Sbjct: 672 NVFVTASRDKTVKVWRHQ-KEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 730 Query: 211 GVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 G + ++ G Q+ + +G + G + ++ Sbjct: 731 GEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKL-FLGVGSSDLSTRIYSL 789 Score = 71.3 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 41/257 (15%), Positives = 84/257 (32%), Gaps = 33/257 (12%) Query: 1 MFQFVTPVGTQNGLK--ATCAKISPDGQFLAITQGLNILIYDINR--RTVSQTLVTSHAR 56 M + +TP G + I + +A G I ++D + H Sbjct: 5 MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEA 64 Query: 57 PFSELCWSPDGQCIATASDDFSVEII---HLSYGLLHTFIGHTAPVISLTFNRKGNLLFT 113 + + + PD + +AS+D V+I S+ I H + I + + +L+ Sbjct: 65 EVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI-VALSALPSLISV 123 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAV---------VSVDVPMNDSSILSSGSYDGLIR 164 D +I IW + + AH + +S+ +L+ G + Sbjct: 124 GCADGTISIWRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT--NVN 180 Query: 165 IF-------DAETGHC--LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 +F D+ C + L +DW + + + L S D +++ Sbjct: 181 VFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRH----QETPGDYLLCSGSQDRYIRL 236 Query: 216 WDCIGGCVVRTFQVQPL 232 W ++ + Sbjct: 237 WRIRINDLIDDSEEDSK 253 Score = 69.0 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 41/212 (19%), Positives = 76/212 (35%), Gaps = 29/212 (13%) Query: 118 ESIKIWDTLNGS---LMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF---DAETG 171 ++I +WD + + + T+ H V V DS + S S D ++I+ D Sbjct: 40 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDYSHL 98 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI-GGCVVRTFQVQ 230 C++T+ + + V S + V DG + IW Sbjct: 99 QCIQTIQHYSK----------TIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEF 148 Query: 231 PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN---SDTKSLLQLLDGSLYHHS 287 ++KG + C L+ + L+ G N +++ + SD+ + L H Sbjct: 149 TIKKGFFYPLCL--SLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHE 206 Query: 288 SPVMSIH------CFGNIMCSLALNGDCCLWR 313 V S+ ++CS + + LWR Sbjct: 207 DWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 238 Score = 59.0 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 40/321 (12%), Positives = 93/321 (28%), Gaps = 70/321 (21%) Query: 18 CAKISP--DGQFLAITQGLNI------LIYDINRRTVSQTL--VTSHARPFSELCW---- 63 C +S + ++L G N+ I + + + + H L + Sbjct: 159 CLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQE 218 Query: 64 SPDGQCIATASDDFSVEIIHLSYGLLHT-------------------------------- 91 +P + + S D + + + L Sbjct: 219 TPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE 278 Query: 92 --FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL---------------NGSLMKTI 134 +GH + SL ++ L ++ D S+ +W+ + T Sbjct: 279 ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 338 Query: 135 SAHSEAVVSVDVPMNDSS-ILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 193 + S S ++ + G R++ + + D+ ++ Sbjct: 339 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDN-----IICDQRLGISGATKDVT 393 Query: 194 QVKFSENARYLLVKSLDGVVKIW-DCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGS 252 + +S + YLL SLD +++ I R ++ + G D + E + Sbjct: 394 DIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVT 453 Query: 253 TPLVISGYENGDIYCWNSDTK 273 +SG + + ++ Sbjct: 454 DTRFVSGGDEKILRSFDLPKG 474 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 26/175 (14%), Positives = 64/175 (36%), Gaps = 16/175 (9%) Query: 131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDG-----LIRIFDAETGHCLKTLTYDKDWKR 185 ++ + H + +D+ D +++S +IRIF E +K Sbjct: 555 VEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIK-------PAL 606 Query: 186 ENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF 245 + I+++KFS++ ++LL D +W+ TF+++ + H D Sbjct: 607 PFHSLTITRLKFSKDGKFLLSVCRDRKWALWE--RNMEDNTFELRFKNEKP-HTRIIWDA 663 Query: 246 LNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIM 300 + ++ + + W + + + H+ V +I +++ Sbjct: 664 DWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMI 718 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 33/188 (17%), Positives = 64/188 (34%), Gaps = 24/188 (12%) Query: 5 VTPVGTQNGLKATCAKISPDGQF-LAITQGLNILIY----DINRRTVSQTLVTSHARPFS 59 + P + L T K S DG+F L++ + ++ + N + H R Sbjct: 602 IKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIW 661 Query: 60 ELCWSP--DGQCIATASDDFSVEIIHLSYGLLHTFI-----GHTAPVISLTFNRK---GN 109 + W+P G TAS D +V++ ++ HT V +++ + Sbjct: 662 DADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREK 721 Query: 110 LLFTSS-MDESIKIWDTLNGSLMKTISAHS-----EAVVSVDVPM---NDSSILSSGSYD 160 +L + + I ++ G + + + + N L GS D Sbjct: 722 ILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSD 781 Query: 161 GLIRIFDA 168 RI+ Sbjct: 782 LSTRIYSL 789 Score = 47.8 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 42/360 (11%), Positives = 102/360 (28%), Gaps = 72/360 (20%) Query: 12 NGLKATCAKISPDG-QFLAI---TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG 67 +G +C + + F T + N + ++ + +++ WSP G Sbjct: 342 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG 401 Query: 68 QCIATASDDFSVEII-------HLSYGLLHTFIGHTAP---------VISLTFNRKGNLL 111 + + S D + + + T+ + P V ++T Sbjct: 402 EYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVT----DTRF 457 Query: 112 FTSSMDESIKIWDTLNG--SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIR----- 164 + ++ ++ +D G +++ M DS+ + Sbjct: 458 VSGGDEKILRSFDLPKGVAGMLQKFVG---IQFEEKSEMPDSATVPVLGLSNKAGEDDAN 514 Query: 165 ---------------IFDAET--------GHCLKTLTYDKDWKRENGVVPISQVKFSENA 201 I D + + L + + K I+ + S + Sbjct: 515 EDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQ 574 Query: 202 RYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLH---HSCGMDFLNPEDGSTPLVIS 258 + + V V+R F + + HS + L ++S Sbjct: 575 KLIASACRSNNV------QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDG-KFLLS 627 Query: 259 GYENGDIYCWNSDTK-SLLQLLDGSLYHHSSPVMSIH----CFGNIMCSLALNGDCCLWR 313 + W + + + +L + H+ + FGN+ + + + +WR Sbjct: 628 VCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 687 Score = 47.1 bits (110), Expect = 9e-06, Method: Composition-based stats. Identities = 26/188 (13%), Positives = 61/188 (32%), Gaps = 35/188 (18%) Query: 17 TCAKISPDG-QFLAITQGLNILIYDINR--------------RTVSQTLVTSHARPFSEL 61 + + Q LA T ++++++ + + + T + F Sbjct: 289 SSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSC 348 Query: 62 CWSPDGQ--CIATASDDFSVEIIHLSYGLLHT----FIGHTAPVISLTFNRKGNLLFTSS 115 W + T S + ++ G T V + ++ G L +S Sbjct: 349 LWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATS 408 Query: 116 MDESIKI---WDTLNGSLMKTISA---------HSEAVVSVDVPMNDSSILSSGSYDGLI 163 +D++ ++ W + I+ H ++ V+ + + SG + ++ Sbjct: 409 LDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTD--TRFVSGGDEKIL 466 Query: 164 RIFDAETG 171 R FD G Sbjct: 467 RSFDLPKG 474 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 18/115 (15%), Positives = 42/115 (36%), Gaps = 14/115 (12%) Query: 202 RYLLVKSLDGVVKIWDC---IGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS 258 + ++ + +WD V T + E + DF+ +S Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM----------VS 80 Query: 259 GYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWR 313 E+ + W S LQ + ++ H+S ++++ +++ +G +WR Sbjct: 81 ASEDHHVKIWKFTDYSHLQCIQ-TIQHYSKTIVALSALPSLISVGCADGTISIWR 134 Score = 31.3 bits (69), Expect = 0.60, Method: Composition-based stats. Identities = 7/65 (10%), Positives = 22/65 (33%), Gaps = 3/65 (4%) Query: 252 STPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHS--SPVMSIHCFGNIMCSLALNGDC 309 +++ I W+ + + + +L H + + M S + + Sbjct: 29 KVKKIVAFGAGKTIALWD-PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHV 87 Query: 310 CLWRW 314 +W++ Sbjct: 88 KIWKF 92 >4PSX-B nrPDB Length = 401 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 31/209 (14%), Positives = 81/209 (38%), Gaps = 15/209 (7%) Query: 25 GQFLAITQGLNILIYDINRR----TVSQTLVTSHARPFSELCWSP-DGQCIATASDDFSV 79 G+ L+ + + ++++ +T H+ ++ W + T S+D + Sbjct: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 Query: 80 EIIHL-SYGLLHTFIGHTAPVISLTF-NRKGNLLFTSSMDESIKIWDTLN-GSLMKTISA 136 +I + + + P +L F + NLL + MD + ++D N + +S Sbjct: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 Query: 137 HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKD------WKRENGVV 190 H +AV +++ + ++ S D + ++D + +T +D Sbjct: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 Query: 191 PISQVKFSENARYLLVKSLDGVV-KIWDC 218 ++ + +L+ + + + ++W C Sbjct: 354 SVNDFDLNPQIPWLVASAEEENILQVWKC 382 Score = 54.4 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 36/222 (16%), Positives = 75/222 (33%), Gaps = 19/222 (8%) Query: 95 HTAPVISLTFNR-KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 H + + N++ T + + ++ + L T+ H + ++ Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLYS-RSEGLQSTLKFHKDNGYALSFSTLVKGR 175 Query: 154 LSSGSYDGLIRIFDAET-GHCLKTLTYDKDWKRENGVVPISQVKFSE-NARYLLVKSLDG 211 L SGS D + +++ + G K + D I+ K+ N S D Sbjct: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDL----HSDIINDNKWHNFNKDLFGTVSEDS 231 Query: 212 VVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS- 270 ++KI D P L S S+ L+ + + +Y ++ Sbjct: 232 LLKINDVRANNTTIDTVKCPQPFNTLAFSHH---------SSNLLAAAGMDSYVYLYDLR 282 Query: 271 DTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + K L + G ++ S H G ++ S + + +W Sbjct: 283 NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMW 323 Score = 52.1 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 33/171 (19%), Positives = 64/171 (37%), Gaps = 21/171 (12%) Query: 20 KISPDGQFLAITQGLNILIYDINRRTVSQTLVTSH-ARPFSELCWSPDG-QCIATASDDF 77 K + L T + L+ + R + T+ T +PF+ L +S +A A D Sbjct: 215 KWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDS 274 Query: 78 SVEIIHLSY--GLLHTFIGHTAPVISLTFNR--KGNLLFTSSMDESIKIWDTLN------ 127 V + L LH GH V +L F+ G ++ +S D + +WD Sbjct: 275 YVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDG-VVVSSGSDNRLMMWDLKQIGAEQT 333 Query: 128 --------GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET 170 L+ + H +V D+ +++S + +++++ Sbjct: 334 PDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSH 384 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 19/130 (14%), Positives = 39/130 (30%), Gaps = 19/130 (14%) Query: 13 GLKATCAKISP--DGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQ-C 69 S A + +YD+ ++ H + L +S Sbjct: 251 PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGV 310 Query: 70 IATASDDFSVEIIHLSY---------------GLLHTFIGHTAPVISLTFNRKGNLLFTS 114 + ++ D + + L L+ GH + V N + L S Sbjct: 311 VVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVAS 370 Query: 115 SMDESI-KIW 123 + +E+I ++W Sbjct: 371 AEEENILQVW 380 >6F1U-h nrPDB Length = 612 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 43/222 (19%), Positives = 86/222 (38%), Gaps = 23/222 (10%) Query: 8 VGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG 67 VGTQN IS DG+ + + + D Q+ + + + + P G Sbjct: 364 VGTQNAHN--LISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVA----VTSMSF-PVG 416 Query: 68 QC--IATASDDFSVE--IIHLSY-GLLHTFIGHTAPVISLTFNRK------GNLLFTSSM 116 S++ SV H S G+ F GH P+ + + +L TSS Sbjct: 417 DVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSF 476 Query: 117 DESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKT 176 D ++K+W T N + + ++ V V ++ + G + +++ + T Sbjct: 477 DWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPT 536 Query: 177 LTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDC 218 + G +++V+++ + R + V +G + I+D Sbjct: 537 AS-----ISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDV 573 Score = 70.9 bits (172), Expect = 7e-13, Method: Composition-based stats. Identities = 39/235 (16%), Positives = 75/235 (31%), Gaps = 28/235 (11%) Query: 99 VISLTFNRKGNLLFTSSM----------DESIKIWDTLNGSLMKTISAH-SEAVVSVDVP 147 V L ++ + L +S D +W+ H AV+S Sbjct: 256 VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFA 315 Query: 148 MNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF--SENARYLL 205 +++ G+Y G I ++D + +T P+ V ++NA L+ Sbjct: 316 KFHPNLVVGGTYSGQIVLWDNRSNK--RTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLI 373 Query: 206 VKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDI 265 S DG + W + ++ + K + D + +V G E G + Sbjct: 374 SISTDGKICSWSLDMLSHPQD-SMELVHKQSKAVAVTSMSFPVGDVNNFVV--GSEEGSV 430 Query: 266 YCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF--------GNIMCSLALNGDCCLW 312 Y + + H P+ IHC ++ + + + LW Sbjct: 431 Y--TACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLW 483 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 47/314 (14%), Positives = 86/314 (27%), Gaps = 58/314 (18%) Query: 17 TCAKISPD-GQFLAITQGLN----------ILIYDINRRTVSQTLVTSHARPFSELCWSP 65 +C S + L + N L++++ + + V ++ Sbjct: 257 SCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAK 316 Query: 66 -DGQCIATASDDFSVEIIHLSYGLLH-------TFIGHTAPVISLTF--NRKGNLLFTSS 115 + + + + + HT PV + + + L + S Sbjct: 317 FHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISIS 376 Query: 116 MDESIKIWDTLNGS----LMKTISAHSEAV--VSVDVPMNDSSILSSGSYDGLIRIFDAE 169 D I W S M+ + S+AV S+ P+ D + GS +G + Sbjct: 377 TDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSV-YTACR 435 Query: 170 TGHCL---KTLTYDKDWKRENGV-VPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR 225 G + + + V FS + S D VK+W + Sbjct: 436 HGSKAGISEMFEGHQGPITGIHCHAAVGAVDFS---HLFVTSSFDWTVKLWSTKNNKPLY 492 Query: 226 TFQVQPL-EKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLY 284 +F+ V+ DG G + WN + Sbjct: 493 SFEDNAGYVYDVMWSPTHPALFACVDGM----------GRLDLWNLNN------------ 530 Query: 285 HHSSPVMSIHCFGN 298 P SI GN Sbjct: 531 DTEVPTASISVEGN 544 >5WLC-SG nrPDB Length = 573 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 48/327 (14%), Positives = 93/327 (28%), Gaps = 61/327 (18%) Query: 48 QTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY----GLLHTFIGHTAPVISLT 103 + H + SPDG+ + T D + + ++ T V+SL Sbjct: 229 ENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDR-RGEVLSLA 287 Query: 104 FNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLI 163 F + + L+ S D I+ + S ++ + H + V + ++ G+ D Sbjct: 288 FRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAM-ERCVTVGARDRTA 346 Query: 164 RIFDA--------ETGHCLKTLTYD--KDWKRENGVVPISQVKFSE-------------- 199 ++ G + L K+ +E + SE Sbjct: 347 MLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVS 406 Query: 200 --NARYLLVKSLDGVVKIWDCIGGCVV---------------RTFQVQPLEKGVLHHSCG 242 + + + S +G + +W + + E+ G Sbjct: 407 MVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQG 466 Query: 243 MDFLNP-------EDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI-- 293 L P + + ISG +G + W L G L V I Sbjct: 467 KKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQV 526 Query: 294 -----HCFGNIMCSLALNGDCCLWRWV 315 H ++ + L RW+ Sbjct: 527 VESGKHGKEKFRILASIAKEHRLGRWI 553 Score = 73.6 bits (179), Expect = 9e-14, Method: Composition-based stats. Identities = 37/323 (11%), Positives = 90/323 (27%), Gaps = 65/323 (20%) Query: 10 TQNGL--KATCAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHAR-PFSELCWSP 65 T G + SPDG+++ ++++ + + + T R L + Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 290 Query: 66 DGQCIATASDDFSVEIIHLS-YGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 + + + DF + ++ + L GH V ++ + + D + +W Sbjct: 291 NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 350 Query: 125 TLNGSLMKTISAHSEAVVSVDVPMN----------------------------------D 150 + + + T E + M D Sbjct: 351 IPDETRL-TFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVD 409 Query: 151 SSILSSGSYDGLIRIFDAETGHCLKT---------------LTYDKDWKRENGVV----- 190 +GS +G I ++ + T ++ + D + + Sbjct: 410 DFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKL 469 Query: 191 ----PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ-PLEKGVLHHSCGMDF 245 I+ + + + S G +K+W + KGV+ ++ Sbjct: 470 LQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVES 529 Query: 246 LNPEDGSTPLVISGYENGDIYCW 268 ++ S + + W Sbjct: 530 GKHGKEKFRILASIAKEHRLGRW 552 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 47/140 (33%), Gaps = 10/140 (7%) Query: 174 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 + T ++ + E I V S + +Y++ D + +W V+ Sbjct: 221 IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVI----PT 276 Query: 234 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 293 K + F D + + + I ++ + S L++L G +H +S Sbjct: 277 KDRRGEVLSLAFRKNSD----QLYASCADFKIRTYSINQFSQLEILYG--HHDIVEDISA 330 Query: 294 HCFGNIMCSLALNGDCCLWR 313 + A + LW+ Sbjct: 331 LAMERCVTVGARDRTAMLWK 350 >5A9Q-7 nrPDB Length = 360 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 41/221 (18%), Positives = 83/221 (37%), Gaps = 16/221 (7%) Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS---LMKTISAHSEAVVSVDVPMND- 150 H + ++F+ G + T S D+S+K+WD + HS +V V + Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 151 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE----NGVVPISQVKFSEN--ARYL 204 +L+S S+D +++ G L W + + ++ VKF+ L Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 205 LVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYEN-- 262 S DG+V+I++ + + +Q L SC + +P++ G ++ Sbjct: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190 Query: 263 ----GDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNI 299 + + + + +L + PV I N+ Sbjct: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNL 231 Score = 79.0 bits (193), Expect = 2e-15, Method: Composition-based stats. Identities = 52/309 (16%), Positives = 113/309 (36%), Gaps = 46/309 (14%) Query: 46 VSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLS----YGLLHTFIGHTAPVIS 101 V++++ H ++ + G+ +AT S D SV++ S + ++ H+ V Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 102 LTFNRK--GNLLFTSSMDESIKIWDTLNGSLMKTISAHSE------------AVVSVDVP 147 +T+ G +L + S D + +W+ + G + S +V V Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122 Query: 148 MND-SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARY--- 203 +L++ S DG++RI++A + L+ + + S + ++ ++ Sbjct: 123 PKHMGLMLATCSADGIVRIYEAPD---VMNLSQWSLQHEISCKLSCSCISWNPSSSRAHS 179 Query: 204 --LLVKSLDGV------VKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 + V S D V+I++ R + V + F S + Sbjct: 180 PMIAVGSDDSSPNAMAKVQIFEY--NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHI 237 Query: 256 VISGYENGDIYCWNSDTKSLLQL---------LDGSLYHHSSPV--MSIHCFGNIMCSLA 304 + ++ I+ K L + +H+S V +S + G ++ S Sbjct: 238 LAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSG 297 Query: 305 LNGDCCLWR 313 +G LW+ Sbjct: 298 DDGCVRLWK 306 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 50/296 (16%), Positives = 95/296 (32%), Gaps = 48/296 (16%) Query: 5 VTPVGTQNGLKATCAKISPD-GQFLAITQ-GLNILIYD-----------INRRTVSQTLV 51 T +G P+ GQ LA +++ V +T + Sbjct: 50 TASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL 109 Query: 52 TSHARPFSELCWSPD--GQCIATASDDFSVEII------HLSYGLLHTFIGHTAPVISLT 103 +++ ++P G +AT S D V I +LS L I ++ Sbjct: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169 Query: 104 FNRKG-----NLLFTSSMDES------IKIW----DTLNGSLMKTISAHSEAVVSVDVPM 148 +N ++ S D S ++I+ +T + +T+ ++ V + Sbjct: 170 WNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAP 229 Query: 149 NDS---SILSSGSYDGLIRIFDAETGHCLKT-------LTYDKDWKRENGVVPISQVKFS 198 N IL+ + D +RIF + T + +N + +V ++ Sbjct: 230 NLGRSFHILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWN 287 Query: 199 ENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTP 254 L DG V++W + + ++ S NP GST Sbjct: 288 ITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTI 343 >4J0X-A nrPDB Length = 451 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 48/327 (14%), Positives = 93/327 (28%), Gaps = 61/327 (18%) Query: 48 QTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSY----GLLHTFIGHTAPVISLT 103 + H + SPDG+ + T D + + ++ T V+SL Sbjct: 107 ENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDR-RGEVLSLA 165 Query: 104 FNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLI 163 F + + L+ S D I+ + S ++ + H + V + ++ G+ D Sbjct: 166 FRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAM-ERCVTVGARDRTA 224 Query: 164 RIFDA--------ETGHCLKTLTYD--KDWKRENGVVPISQVKFSE-------------- 199 ++ G + L K+ +E + SE Sbjct: 225 MLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVS 284 Query: 200 --NARYLLVKSLDGVVKIWDCIGGCVV---------------RTFQVQPLEKGVLHHSCG 242 + + + S +G + +W + + E+ G Sbjct: 285 MVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQG 344 Query: 243 MDFLNP-------EDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI-- 293 L P + + ISG +G + W L G L V I Sbjct: 345 KKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQV 404 Query: 294 -----HCFGNIMCSLALNGDCCLWRWV 315 H ++ + L RW+ Sbjct: 405 VESGKHGKEKFRILASIAKEHRLGRWI 431 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 37/323 (11%), Positives = 90/323 (27%), Gaps = 65/323 (20%) Query: 10 TQNGL--KATCAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHAR-PFSELCWSP 65 T G + SPDG+++ ++++ + + + T R L + Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 168 Query: 66 DGQCIATASDDFSVEIIHLS-YGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 + + + DF + ++ + L GH V ++ + + D + +W Sbjct: 169 NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 228 Query: 125 TLNGSLMKTISAHSEAVVSVDVPMN----------------------------------D 150 + + + T E + M D Sbjct: 229 IPDETRL-TFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVD 287 Query: 151 SSILSSGSYDGLIRIFDAETGHCLKT---------------LTYDKDWKRENGVV----- 190 +GS +G I ++ + T ++ + D + + Sbjct: 288 DFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKRQLQGKKL 347 Query: 191 ----PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ-PLEKGVLHHSCGMDF 245 I+ + + + S G +K+W + KGV+ ++ Sbjct: 348 LQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVES 407 Query: 246 LNPEDGSTPLVISGYENGDIYCW 268 ++ S + + W Sbjct: 408 GKHGKEKFRILASIAKEHRLGRW 430 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 47/140 (33%), Gaps = 10/140 (7%) Query: 174 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 + T ++ + E I V S + +Y++ D + +W V+ Sbjct: 99 IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVI----PT 154 Query: 234 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 293 K + F D + + + I ++ + S L++L G +H +S Sbjct: 155 KDRRGEVLSLAFRKNSD----QLYASCADFKIRTYSINQFSQLEILYG--HHDIVEDISA 208 Query: 294 HCFGNIMCSLALNGDCCLWR 313 + A + LW+ Sbjct: 209 LAMERCVTVGARDRTAMLWK 228 >2PM9-A nrPDB Length = 416 Score = 79.8 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 45/302 (14%), Positives = 106/302 (35%), Gaps = 32/302 (10%) Query: 31 TQGLNILIYDINRRTVSQTLVTSHARP-FSELCWSPDGQCIATASDDFSVEIIHLS---- 85 + ++ ++ + + + + F++L WS + + IA A D+ S+E+ + Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANN 101 Query: 86 -YGLLHTFIGHTAPVISLTFN-RKGNLLFTSSMDESIKIWDTLN-----GSLMKTISAHS 138 + F H++ V ++ FN ++ N+L + + I IWD + S Sbjct: 102 AINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQS 161 Query: 139 ----EAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ 194 + V+S+ + + + +S I+D + + L+Y +S Sbjct: 162 MSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTS--PNSGIKQQLSV 219 Query: 195 VKFSENAR---YLLVKSL-DGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 V++ S D + IWD +Q L +G +D+ + ++ Sbjct: 220 VEWHPKNSTRVATATGSDNDPSILIWDLRN----ANTPLQTLNQGHQKGILSLDWCHQDE 275 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFG-NIMCSLALNGDC 309 L++S + + WN ++ L ++ + + Sbjct: 276 ---HLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKT--KFAPEAPDLFACASFDNKI 330 Query: 310 CL 311 + Sbjct: 331 EV 332 Score = 78.3 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 45/288 (15%), Positives = 97/288 (33%), Gaps = 16/288 (5%) Query: 38 IYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHL---SYGLLHTFIG 94 + + + + T SH + + + G A S D S+E+ L + Sbjct: 6 MVKLAEFSRTATFAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQ 65 Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS----LMKTISAHSEAVVSVDVPMND 150 + L ++ ++ + + S++++ T + M S HS +V +V Sbjct: 66 VDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQ 125 Query: 151 SSILSSGSYDGLIRIFDAET-GHCLKTLTYDKDWKRENGVVPISQVKFSEN-ARYLLVKS 208 ++L+SG +G I I+D T + + V + + ++++ A Sbjct: 126 DNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAG 185 Query: 209 LDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 IWD V G+ +++ + I W Sbjct: 186 SSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIW 245 Query: 269 NSDT-KSLLQLLDGSLYHHSSPVMSI---HCFGNIMCSLALNGDCCLW 312 + + LQ L+ H ++S+ H +++ S + LW Sbjct: 246 DLRNANTPLQTLN---QGHQKGILSLDWCHQDEHLLLSSGRDNTVLLW 290 Score = 78.3 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 43/225 (19%), Positives = 81/225 (36%), Gaps = 31/225 (13%) Query: 15 KATCAKISPDGQFLAITQGLN--ILIYDINRRTVSQT----LVTSHA----RPFSELCWS 64 K + + + G N I I+D+N+ T S + L + L W+ Sbjct: 115 SVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWN 174 Query: 65 PD-GQCIATASDDFSVEIIHLSYGLLHTFIGHTAP-------VISLTFNRKGNL---LFT 113 A+A I L + +T+P + + ++ K + T Sbjct: 175 QSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATAT 234 Query: 114 SSM-DESIKIWDTLN-GSLMKTIS-AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET 170 S D SI IWD N + ++T++ H + ++S+D D +L S D + +++ E+ Sbjct: 235 GSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPES 294 Query: 171 GHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 L +W + P E S D +++ Sbjct: 295 AEQLSQFPARGNWCFKTKFAP-------EAPDLFACASFDNKIEV 332 Score = 62.5 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 35/236 (14%), Positives = 82/236 (34%), Gaps = 34/236 (14%) Query: 19 AKISPDGQFLAITQGLN-ILIYDINRR---TVSQTLVTSHARPFSELCWS-PDGQCIATA 73 S + + +A + +Y N S ++H+ + ++ +A+ Sbjct: 73 LDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASG 132 Query: 74 SDDFSVEIIHLS------YGLLHTFIGHTA----PVISLTFNRK-GNLLFTSSMDESIKI 122 ++ + I ++ G + VISL +N+ ++ ++ I Sbjct: 133 GNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASI 192 Query: 123 WDTLNGSLM--KTISAHSEAVVS----VDVPMNDSSILSS--GSY-DGLIRIFDAET-GH 172 WD + + ++ + + V+ +S+ +++ GS D I I+D Sbjct: 193 WDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANT 252 Query: 173 CLKTLTYDKDWKRENGVVPISQVKF-SENARYLLVKSLDGVVKIWDCIGGCVVRTF 227 L+TL + I + + ++ LL D V +W+ + F Sbjct: 253 PLQTL-------NQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQF 301 >5FA5-B nrPDB Length = 367 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 43/226 (19%), Positives = 76/226 (33%), Gaps = 22/226 (9%) Query: 58 FSELCWSPDGQCIATASDDFSVEIIHLSYGLLHT-----FIGHTAPVISLTFNRKGNLLF 112 ++L W + + ASD +VE+ L H V +++ G Sbjct: 108 VADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV 166 Query: 113 TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 + S D IK+WD ++ + AH+ V V + S+ S S D I ++D Sbjct: 167 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 226 Query: 173 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLV-KSLDGVVKIWDCIGGCVVRTFQVQP 231 + G +P + + + + V +G V + D V Sbjct: 227 PASQI-----GCSAPGYLP-TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV------- 273 Query: 232 LEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQ 277 HS + L S P + S E+ + +S L + Sbjct: 274 --LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFR 317 Score = 77.5 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 38/238 (15%), Positives = 82/238 (34%), Gaps = 16/238 (6%) Query: 27 FLAITQGLNILIYDINRRT---VSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIH 83 L + + +++++ VS+ H S + G + S D +++ Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 84 LSYG-LLHTFIGHTAPVISLTFNRKGNLLF-TSSMDESIKIWDTLNGSLMKTI--SAHSE 139 L+ +L ++ H A V + + + +F + S D I +WDT I SA Sbjct: 179 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 238 Query: 140 AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE 199 S+ S + G +G + + D ++ C+ ++ + FS Sbjct: 239 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCV--------LSSAVHSQCVTGLVFSP 290 Query: 200 NA-RYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLV 256 ++ +L S D + + D + R+ + + L +V Sbjct: 291 HSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 348 Score = 71.3 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 35/204 (17%), Positives = 85/204 (41%), Gaps = 16/204 (7%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPD-GQCIATAS 74 +T + +S Q ++ ++ + I ++D+ ++ V + +HA + + SP + S Sbjct: 154 STVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY-RAHAAQVTCVAASPHKDSVFLSCS 212 Query: 75 DDFSVEIIHLSYGLLHTFIGHTAP---VISLTFNRKGNLLFT-SSMDESIKIWDTLNGSL 130 +D + + + IG +AP SL ++ + + +F + ++ + DT + S Sbjct: 213 EDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSC 272 Query: 131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV 190 + + + HS+ V + + L+S S D + + D+ + + ++ + Sbjct: 273 VLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDS---------SLSELFRSQAHRD 323 Query: 191 PISQVKFSE-NARYLLVKSLDGVV 213 + +S N L D V Sbjct: 324 FVRDATWSPLNHSLLTTVGWDHQV 347 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 24/175 (13%), Positives = 57/175 (32%), Gaps = 16/175 (9%) Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 V + +++S S G + +++ + L + + +S V Sbjct: 105 EAGVADLTWVGERGILVASDS--GAVELWELDENETLIV----SKFCKYEHDDIVSTVSV 158 Query: 198 SENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVI 257 + + S D +K+WD V+ +++ + + S D + + Sbjct: 159 LSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKD---------SVFL 209 Query: 258 SGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN-IMCSLALNGDCCL 311 S E+ I W++ + S + ++ H + + NG L Sbjct: 210 SCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSL 264 Score = 28.2 bits (61), Expect = 5.5, Method: Composition-based stats. Identities = 10/59 (16%), Positives = 21/59 (35%), Gaps = 2/59 (3%) Query: 256 VISGYENGDIYCWNSDTKSLLQLLDGSLYHHSS--PVMSIHCFGNIMCSLALNGDCCLW 312 ++ ++G + W D L + Y H +S+ G S + + +W Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVW 177 >6EM1-m nrPDB Length = 807 Score = 78.3 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 34/163 (20%), Positives = 69/163 (42%), Gaps = 17/163 (10%) Query: 19 AKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFS 78 AK P L + + IYD++++ + + L+ AR S++ P G + +S D Sbjct: 645 AKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPG-ARWLSKIDIHPRGDNLIASSFDKR 703 Query: 79 V--EIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW------DTLNG-- 128 V + L+ T H V S+ F++K L +++ D +I ++ D + Sbjct: 704 VLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPM 763 Query: 129 -SLMKTISAHSEAVVSV----DVPMNDSSILSSGSYDGLIRIF 166 +K ++ H + + S+ + + L S D R++ Sbjct: 764 IVPLKKLTGH-KVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 76.3 bits (186), Expect = 1e-14, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 77/225 (34%), Gaps = 24/225 (10%) Query: 55 ARPFSELCWSPDGQCIATA---SDDFSVEIIHLSYGLLHT-FIGHTAPVISLTFNRKGNL 110 + +L W G T S + SV I +S L + F ++ F+ Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 653 Query: 111 LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE- 169 LF S ++I+D L+K + + + +D+ ++++S S+D + D + Sbjct: 654 LFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWHDLDL 711 Query: 170 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW------DCIGGCV 223 KTL Y + + V F + + DG + ++ D + + Sbjct: 712 ASTPYKTLRYHEK--------AVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPM 763 Query: 224 VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 + + K + +P + + S + W Sbjct: 764 IVPLKKLTGHKVINSLGVLDAIWHPRE---AWLFSAGADNTARLW 805 Score = 61.3 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 53/335 (15%), Positives = 95/335 (28%), Gaps = 59/335 (17%) Query: 18 CAKISPDGQ--FLAITQGLNILI-------YDINRRTVSQTLVTSHARPFSELC-----W 63 C + +PD LA+ G NI + YDI ++ F + Sbjct: 490 CIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEV 549 Query: 64 SPDG-------QCIATASDDFSVEIIHLSY-----GLLHTFIGHTAPVISLTFNRKGNLL 111 + +G A + V + + I V L+++RKG+ Sbjct: 550 NENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYF 609 Query: 112 FTSSMDE---SIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 T D S+ I ++ + +RI+D Sbjct: 610 VTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS--QRYVRIYDL 667 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 +K L W +S++ L+ S D V +W + Sbjct: 668 SQQILVKKLLPGARW--------LSKIDIHPRGDNLIASSFDKRV-LWHDLD------LA 712 Query: 229 VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS---------LLQLL 279 P + H + PL S ++G I+ +++ L+ L Sbjct: 713 STPYKTLRYHEKAVRSVNFHK--KLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKL 770 Query: 280 DGSLYHHSSPVMSI--HCFGNIMCSLALNGDCCLW 312 G +S V+ H + S + LW Sbjct: 771 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 28/191 (14%), Positives = 66/191 (34%), Gaps = 16/191 (8%) Query: 129 SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENG 188 + H V ++ + L++GS DG +R+++ TG + T D EN Sbjct: 428 RCSTIYAGHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLIDD--EENP 484 Query: 189 VVPISQVKFSENARY-LLVKSLDGVVKI-------WDCIGGCVVRTFQVQPLEKGVLHHS 240 I ++++ +A +L ++ + + +D + + Sbjct: 485 DYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKK 544 Query: 241 CGMDFLNPEDGSTPLVISGYEN---GDIYCWNS-DTKSLLQLLDGSLY-HHSSPVMSIHC 295 ++ DG +N + WN K L + + ++ + +S H Sbjct: 545 SNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR 604 Query: 296 FGNIMCSLALN 306 G+ ++ + Sbjct: 605 KGDYFVTVQPD 615 Score = 51.7 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 48/300 (16%), Positives = 93/300 (31%), Gaps = 56/300 (18%) Query: 47 SQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-------LLHTFIGHTAPV 99 T+ H L P G +AT SDD +V + + G L+ + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 100 ISLTFNRKGN--LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSG 157 + +N N +L + G + I + D+ N + + G Sbjct: 489 ECIEWNPDANNGILAVA------------VGENIHLIVP---PIFGYDIENNGKTKIEDG 533 Query: 158 -SYD--GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ--VKFS-ENARYL-----LV 206 YD G ++ + E D+D + E+ + + +++ + + L + Sbjct: 534 FGYDTFGTVKKSNLEVNENGD---GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICIT 590 Query: 207 KSLDGVVK--IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE--- 261 S VK W G T Q VL H + +I + Sbjct: 591 ISCKKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHP 649 Query: 262 ---------NGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + ++ + L++ L S + IH G+ + + + + LW Sbjct: 650 FKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSK--IDIHPRGDNLIASSFDKRV-LW 706 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 43/332 (12%), Positives = 94/332 (28%), Gaps = 52/332 (15%) Query: 14 LKATCAKISPDGQFLAITQGL-NILIYDINR-RTVSQTLVTSHARP----FSELCWSPD- 66 K I P G +LA + +++I R V +T + + W+PD Sbjct: 438 GKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDA 497 Query: 67 -GQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFT---------SSM 116 +A A + I+ +G G T ++ G + + Sbjct: 498 NNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDE 557 Query: 117 D-----------ESIKIWDTLNGSLMK----TISAHSEAVVSVDVPMNDSSILSSGSYDG 161 D + + W+ + ++ + + V + ++ G Sbjct: 558 DGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSG 617 Query: 162 LIRIFDAETGHCLKTLTYD-KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIG 220 T + ++ + I KF L V S V+I+D Sbjct: 618 -------NTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQ 669 Query: 221 GCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLD 280 +V+ + D D +I+ + + W+ + Sbjct: 670 QILVKKLLPGARWLSKI------DIHPRGDN----LIASSFDKRV-LWHDLDLASTPYKT 718 Query: 281 GSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + + ++ H + S A +G ++ Sbjct: 719 LRYHEKAVRSVNFHKKLPLFSSAADDGTIHVF 750 >5BJS-A nrPDB Length = 605 Score = 77.9 bits (190), Expect = 5e-15, Method: Composition-based stats. Identities = 43/215 (20%), Positives = 78/215 (36%), Gaps = 30/215 (13%) Query: 12 NGLKATCAK-ISPD----GQFLAITQGL-NILIYDINRRTVSQTLVTSHARPFSELCWSP 65 +G +A CA S D L I N+ +Y++ + +TLV H ++L SP Sbjct: 130 DGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLV-GHGGGINDLATSP 188 Query: 66 DGQCI-ATASDDFSVEIIHLSYGLLHTF-------IGHTAPVISLTFNRKGNLLFTSSMD 117 I A+ASDD ++ I L+ GH+ ++S+ F+ G + ++ D Sbjct: 189 ANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHD 248 Query: 118 ESIKIWDTLNGSLMK-------------TISAHSEAVVSVDVPMNDSSILSSGSYDGLIR 164 + I +W + H+ V V ILS ++ I Sbjct: 249 QVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAF--YGDLILSRACHEDTIV 306 Query: 165 IFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE 199 ++ E + D + ++ F+ Sbjct: 307 LWRIEGFSSDDPIPGPLDAPTPTDMTKQTRSYFTP 341 Score = 77.5 bits (189), Expect = 6e-15, Method: Composition-based stats. Identities = 40/190 (21%), Positives = 68/190 (35%), Gaps = 18/190 (9%) Query: 107 KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 166 LL + + ++K+++ G L +T+ H + + + I++S S D IRI+ Sbjct: 147 DQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW 206 Query: 167 DAETGH----CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGC 222 H C+ L E + V F +N RY+L D V+ +W Sbjct: 207 SLAPEHEKQPCVCILGG------EGHSYDLLSVAFHDNGRYVLSAGHDQVINLW--ALPE 258 Query: 223 VVRTFQVQPLEKGVLHHSCGMDFLNPED-----GSTPLVISGYENGDIYCWNSDTKSLLQ 277 P+ H S N D G L + +E+ I W + S Sbjct: 259 FPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHED-TIVLWRIEGFSSDD 317 Query: 278 LLDGSLYHHS 287 + G L + Sbjct: 318 PIPGPLDAPT 327 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 59/156 (37%), Gaps = 25/156 (16%) Query: 173 CLKTLTYDKDWK--------RENGVVPISQVKFSENA----RYLLVKSLDGVVKIWDCIG 220 C T T DKD R++G +S++ L + +G VK+++ Sbjct: 108 CRLTQTTDKDANPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTE 167 Query: 221 GCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS----DTKSLL 276 G + RT + H G++ L + ++ S ++ I W+ + + + Sbjct: 168 GKLYRTL---------VGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCV 218 Query: 277 QLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 +L G + + ++ H G + S + LW Sbjct: 219 CILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 >6C0F-s nrPDB Length = 807 Score = 77.9 bits (190), Expect = 5e-15, Method: Composition-based stats. Identities = 34/163 (20%), Positives = 69/163 (42%), Gaps = 17/163 (10%) Query: 19 AKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFS 78 AK P L + + IYD++++ + + L+ AR S++ P G + +S D Sbjct: 645 AKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPG-ARWLSKIDIHPRGDNLIASSFDKR 703 Query: 79 V--EIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW------DTLNG-- 128 V + L+ T H V S+ F++K L +++ D +I ++ D + Sbjct: 704 VLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPM 763 Query: 129 -SLMKTISAHSEAVVSV----DVPMNDSSILSSGSYDGLIRIF 166 +K ++ H + + S+ + + L S D R++ Sbjct: 764 IVPLKKLTGH-KVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 76.0 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 77/225 (34%), Gaps = 24/225 (10%) Query: 55 ARPFSELCWSPDGQCIATA---SDDFSVEIIHLSYGLLHT-FIGHTAPVISLTFNRKGNL 110 + +L W G T S + SV I +S L + F ++ F+ Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 653 Query: 111 LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE- 169 LF S ++I+D L+K + + + +D+ ++++S S+D + D + Sbjct: 654 LFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWHDLDL 711 Query: 170 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW------DCIGGCV 223 KTL Y + + V F + + DG + ++ D + + Sbjct: 712 ASTPYKTLRYHEK--------AVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPM 763 Query: 224 VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 + + K + +P + + S + W Sbjct: 764 IVPLKKLTGHKVINSLGVLDAIWHPRE---AWLFSAGADNTARLW 805 Score = 60.9 bits (146), Expect = 6e-10, Method: Composition-based stats. Identities = 53/335 (15%), Positives = 95/335 (28%), Gaps = 59/335 (17%) Query: 18 CAKISPDGQ--FLAITQGLNILI-------YDINRRTVSQTLVTSHARPFSELC-----W 63 C + +PD LA+ G NI + YDI ++ F + Sbjct: 490 CIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEV 549 Query: 64 SPDG-------QCIATASDDFSVEIIHLSY-----GLLHTFIGHTAPVISLTFNRKGNLL 111 + +G A + V + + I V L+++RKG+ Sbjct: 550 NENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYF 609 Query: 112 FTSSMDE---SIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 T D S+ I ++ + +RI+D Sbjct: 610 VTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS--QRYVRIYDL 667 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 +K L W +S++ L+ S D V +W + Sbjct: 668 SQQILVKKLLPGARW--------LSKIDIHPRGDNLIASSFDKRV-LWHDLD------LA 712 Query: 229 VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS---------LLQLL 279 P + H + PL S ++G I+ +++ L+ L Sbjct: 713 STPYKTLRYHEKAVRSVNFHK--KLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKL 770 Query: 280 DGSLYHHSSPVMSI--HCFGNIMCSLALNGDCCLW 312 G +S V+ H + S + LW Sbjct: 771 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 28/191 (14%), Positives = 66/191 (34%), Gaps = 16/191 (8%) Query: 129 SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENG 188 + H V ++ + L++GS DG +R+++ TG + T D EN Sbjct: 428 RCSTIYAGHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLIDD--EENP 484 Query: 189 VVPISQVKFSENARY-LLVKSLDGVVKI-------WDCIGGCVVRTFQVQPLEKGVLHHS 240 I ++++ +A +L ++ + + +D + + Sbjct: 485 DYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKK 544 Query: 241 CGMDFLNPEDGSTPLVISGYEN---GDIYCWNS-DTKSLLQLLDGSLY-HHSSPVMSIHC 295 ++ DG +N + WN K L + + ++ + +S H Sbjct: 545 SNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR 604 Query: 296 FGNIMCSLALN 306 G+ ++ + Sbjct: 605 KGDYFVTVQPD 615 Score = 51.7 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 23/48 (47%) Query: 88 LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 + GH V +L+ + G L T S D ++++W+ L G + + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTT 476 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 48/300 (16%), Positives = 93/300 (31%), Gaps = 56/300 (18%) Query: 47 SQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-------LLHTFIGHTAPV 99 T+ H L P G +AT SDD +V + + G L+ + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 100 ISLTFNRKGN--LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSG 157 + +N N +L + G + I + D+ N + + G Sbjct: 489 ECIEWNPDANNGILAVA------------VGENIHLIVP---PIFGYDIENNGKTKIEDG 533 Query: 158 -SYD--GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ--VKFS-ENARYL-----LV 206 YD G ++ + E D+D + E+ + + +++ + + L + Sbjct: 534 FGYDTFGTVKKSNLEVNENGD---GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICIT 590 Query: 207 KSLDGVVK--IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE--- 261 S VK W G T Q VL H + +I + Sbjct: 591 ISCKKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHP 649 Query: 262 ---------NGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + ++ + L++ L S + IH G+ + + + + LW Sbjct: 650 FKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSK--IDIHPRGDNLIASSFDKRV-LW 706 >6CB1-s nrPDB Length = 569 Score = 77.9 bits (190), Expect = 6e-15, Method: Composition-based stats. Identities = 34/163 (20%), Positives = 69/163 (42%), Gaps = 17/163 (10%) Query: 19 AKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFS 78 AK P L + + IYD++++ + + L+ AR S++ P G + +S D Sbjct: 407 AKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPG-ARWLSKIDIHPRGDNLIASSFDKR 465 Query: 79 V--EIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW------DTLNG-- 128 V + L+ T H V S+ F++K L +++ D +I ++ D + Sbjct: 466 VLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPM 525 Query: 129 -SLMKTISAHSEAVVSV----DVPMNDSSILSSGSYDGLIRIF 166 +K ++ H + + S+ + + L S D R++ Sbjct: 526 IVPLKKLTGH-KVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 76.0 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 77/225 (34%), Gaps = 24/225 (10%) Query: 55 ARPFSELCWSPDGQCIATA---SDDFSVEIIHLSYGLLHT-FIGHTAPVISLTFNRKGNL 110 + +L W G T S + SV I +S L + F ++ F+ Sbjct: 356 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 415 Query: 111 LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE- 169 LF S ++I+D L+K + + + +D+ ++++S S+D + D + Sbjct: 416 LFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWHDLDL 473 Query: 170 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW------DCIGGCV 223 KTL Y + + V F + + DG + ++ D + + Sbjct: 474 ASTPYKTLRYHEK--------AVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPM 525 Query: 224 VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 + + K + +P + + S + W Sbjct: 526 IVPLKKLTGHKVINSLGVLDAIWHPRE---AWLFSAGADNTARLW 567 Score = 60.9 bits (146), Expect = 7e-10, Method: Composition-based stats. Identities = 53/335 (15%), Positives = 95/335 (28%), Gaps = 59/335 (17%) Query: 18 CAKISPDGQ--FLAITQGLNILI-------YDINRRTVSQTLVTSHARPFSELC-----W 63 C + +PD LA+ G NI + YDI ++ F + Sbjct: 252 CIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEV 311 Query: 64 SPDG-------QCIATASDDFSVEIIHLSY-----GLLHTFIGHTAPVISLTFNRKGNLL 111 + +G A + V + + I V L+++RKG+ Sbjct: 312 NENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYF 371 Query: 112 FTSSMDE---SIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 T D S+ I ++ + +RI+D Sbjct: 372 VTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCS--QRYVRIYDL 429 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 +K L W +S++ L+ S D V +W + Sbjct: 430 SQQILVKKLLPGARW--------LSKIDIHPRGDNLIASSFDKRV-LWHDLD------LA 474 Query: 229 VQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS---------LLQLL 279 P + H + PL S ++G I+ +++ L+ L Sbjct: 475 STPYKTLRYHEKAVRSVNFHK--KLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKL 532 Query: 280 DGSLYHHSSPVMSI--HCFGNIMCSLALNGDCCLW 312 G +S V+ H + S + LW Sbjct: 533 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 28/191 (14%), Positives = 66/191 (34%), Gaps = 16/191 (8%) Query: 129 SLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENG 188 + H V ++ + L++GS DG +R+++ TG + T D EN Sbjct: 190 RCSTIYAGHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLIDD--EENP 246 Query: 189 VVPISQVKFSENARY-LLVKSLDGVVKI-------WDCIGGCVVRTFQVQPLEKGVLHHS 240 I ++++ +A +L ++ + + +D + + Sbjct: 247 DYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKK 306 Query: 241 CGMDFLNPEDGSTPLVISGYEN---GDIYCWNS-DTKSLLQLLDGSLY-HHSSPVMSIHC 295 ++ DG +N + WN K L + + ++ + +S H Sbjct: 307 SNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHR 366 Query: 296 FGNIMCSLALN 306 G+ ++ + Sbjct: 367 KGDYFVTVQPD 377 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 23/48 (47%) Query: 88 LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 + GH V +L+ + G L T S D ++++W+ L G + + Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTT 238 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 48/300 (16%), Positives = 93/300 (31%), Gaps = 56/300 (18%) Query: 47 SQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-------LLHTFIGHTAPV 99 T+ H L P G +AT SDD +V + + G L+ + Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 250 Query: 100 ISLTFNRKGN--LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSG 157 + +N N +L + G + I + D+ N + + G Sbjct: 251 ECIEWNPDANNGILAVA------------VGENIHLIVP---PIFGYDIENNGKTKIEDG 295 Query: 158 -SYD--GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ--VKFS-ENARYL-----LV 206 YD G ++ + E D+D + E+ + + +++ + + L + Sbjct: 296 FGYDTFGTVKKSNLEVNENGD---GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICIT 352 Query: 207 KSLDGVVK--IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE--- 261 S VK W G T Q VL H + +I + Sbjct: 353 ISCKKTVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHP 411 Query: 262 ---------NGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + ++ + L++ L S + IH G+ + + + + LW Sbjct: 412 FKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSK--IDIHPRGDNLIASSFDKRV-LW 468 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 43/332 (12%), Positives = 94/332 (28%), Gaps = 52/332 (15%) Query: 14 LKATCAKISPDGQFLAITQGL-NILIYDINR-RTVSQTLVTSHARP----FSELCWSPD- 66 K I P G +LA + +++I R V +T + + W+PD Sbjct: 200 GKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDA 259 Query: 67 -GQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFT---------SSM 116 +A A + I+ +G G T ++ G + + Sbjct: 260 NNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDE 319 Query: 117 D-----------ESIKIWDTLNGSLMK----TISAHSEAVVSVDVPMNDSSILSSGSYDG 161 D + + W+ + ++ + + V + ++ G Sbjct: 320 DGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSG 379 Query: 162 LIRIFDAETGHCLKTLTYD-KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIG 220 T + ++ + I KF L V S V+I+D Sbjct: 380 -------NTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQ 431 Query: 221 GCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLD 280 +V+ + D D +I+ + + W+ + Sbjct: 432 QILVKKLLPGARWLSKI------DIHPRGDN----LIASSFDKRV-LWHDLDLASTPYKT 480 Query: 281 GSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + + ++ H + S A +G ++ Sbjct: 481 LRYHEKAVRSVNFHKKLPLFSSAADDGTIHVF 512 >1PI6-A nrPDB Length = 615 Score = 76.7 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 91/270 (33%), Gaps = 37/270 (13%) Query: 51 VTSHARPFSELCWSPDGQC-IATASDDFSVEIIHLS----YGLLHTFIGHTAPVISLTFN 105 V+ H++ + T DD SV T + V + F+ Sbjct: 156 VSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFS 215 Query: 106 RK-GNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVS--VDVPMNDSSILSSGSYDGL 162 G + T D I +D +G +K I E V + DS ++ D Sbjct: 216 PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 Query: 163 IRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGC 222 IR++D T C++ T DK V ++ ++ SLDG + ++ Sbjct: 276 IRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT-----GNGRIISLSLDGTLNFYELGHDE 330 Query: 223 VVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGS 282 V++T L + +ISG +G I W+S + Sbjct: 331 VLKTISGHNKGITALTVNP--------------LISGSYDGRIMEWSSSS---------M 367 Query: 283 LYHHSSPVMSI-HCFGNIMCSLALNGDCCL 311 HS+ ++S+ + S++ + + Sbjct: 368 HQDHSNLIVSLDNSKAQEYSSISWDDTLKV 397 Score = 74.8 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 48/362 (13%), Positives = 111/362 (30%), Gaps = 85/362 (23%) Query: 16 ATCAKISPDGQFLAITQGLNILIY---DINRRTVSQTLVTSH-ARPFSELCWSP--DGQC 69 T P +A G + + D + + T H + + + +SP Q Sbjct: 21 TTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQY 80 Query: 70 IATASDDFSVEII---------HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDES- 119 + + + V + + + F P+ ++++ +G L Sbjct: 81 LCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDN 140 Query: 120 --IKI-WDTLNGSLMKTISAHSE------------------------------------- 139 + I WD +G+ + +S HS+ Sbjct: 141 FGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSAS 198 Query: 140 ---------AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV 190 V V+ + + + D I FD ++G LK + D++ + Sbjct: 199 DRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGG--- 255 Query: 191 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 I + + +++ D +++WD V+ + + + G Sbjct: 256 -IFALSWL-DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT------ 307 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 +IS +G + + +L+ + G H+ + ++ N + S + +G Sbjct: 308 -GNGRIISLSLDGTLNFYELGHDEVLKTISG----HNKGITALTV--NPLISGSYDGRIM 360 Query: 311 LW 312 W Sbjct: 361 EW 362 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 54/318 (16%), Positives = 120/318 (37%), Gaps = 43/318 (13%) Query: 24 DGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIH 83 +G+ ++++ + Y++ V +T+ + H + + L +P + + S D + Sbjct: 309 NGRIISLSLDGTLNFYELGHDEVLKTI-SGHNKGITALTVNP----LISGSYDGRIMEWS 363 Query: 84 LSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT---LNGSLMKTISAHSEA 140 S H+ ++SL ++ + S D+++K+ GS K SA+++ Sbjct: 364 SSS----MHQDHSNLIVSLDNSKAQEY-SSISWDDTLKVNGITKHEFGSQPKVASANNDG 418 Query: 141 VVSVDVPMNDSSILSSGSYD--GLIRIFD---------------AETGHCLKTLTYDKDW 183 +V +D IL S + D +R+ E G+ ++ Sbjct: 419 FTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLE 478 Query: 184 KRENGVVPI----SQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEK-GVLH 238 + P+ S + S + Y+ + G + ++D V + K + Sbjct: 479 VSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAIS 538 Query: 239 HSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF-- 296 N E+ LV +G + +I+ ++ K ++++ L H V ++ Sbjct: 539 WKPAEKGANEEEIEEDLVATGSLDTNIFIYSV--KRPMKIIKA-LNAHKDGVNNLLWETP 595 Query: 297 GNIMCSLALNGDCCLWRW 314 ++ S A D C+ RW Sbjct: 596 STLVSSGA---DACIKRW 610 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 26/120 (21%), Positives = 44/120 (36%), Gaps = 14/120 (11%) Query: 19 AKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSP----------DG 67 ISP ++A IL+YD+ R V + + + W P + Sbjct: 494 ISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAISWKPAEKGANEEEIEE 553 Query: 68 QCIATASDDFSVEIIHL--SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT 125 +AT S D ++ I + ++ H V +L + L +S D IK W+ Sbjct: 554 DLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGADACIKRWNV 612 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 30/225 (13%), Positives = 79/225 (35%), Gaps = 33/225 (14%) Query: 11 QNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI 70 + G + A + DG +T ++LI + +++ P S + S + + Sbjct: 404 EFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRL--NSPGSAVSLSQN--YV 459 Query: 71 ATA-SDDFSVEII-----HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 124 A + ++++ +S+ L + + + + + + I ++D Sbjct: 460 AVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYI---SISPSETYIAAGDVMGKILLYD 516 Query: 125 TLNGSLMKTISA-HSEAVVSVDVPMND---------SSILSSGSYDGLIRIFDA-ETGHC 173 + + + A + + ++ + ++++GS D I I+ Sbjct: 517 LQSREVKTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKI 576 Query: 174 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDC 218 +K L KD ++ + + E L+ D +K W+ Sbjct: 577 IKALNAHKD--------GVNNLLW-ETPSTLVSSGADACIKRWNV 612 >5K19-A nrPDB Length = 569 Score = 74.4 bits (181), Expect = 6e-14, Method: Composition-based stats. Identities = 39/252 (15%), Positives = 78/252 (30%), Gaps = 17/252 (6%) Query: 14 LKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 73 ++ TC +P Q L + + T +E +SPDG+ +A Sbjct: 179 VEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACV 238 Query: 74 SDDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK 132 S D + + + LH T + ++ + ++ G + T D+ + +W ++ ++ Sbjct: 239 SQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIA 298 Query: 133 TISAHSEAVVSVDVPM------NDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 186 H V V + SGS + + T + Sbjct: 299 RGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNST 358 Query: 187 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 246 + +F D + +WD + F QPL + H + Sbjct: 359 DSRPVSVTYRFG-------SVGQDTQLCLWDLTEDIL---FPHQPLSRARTHTNVMNATS 408 Query: 247 NPEDGSTPLVIS 258 P + V + Sbjct: 409 PPAGSNGNSVTT 420 Score = 47.1 bits (110), Expect = 9e-06, Method: Composition-based stats. Identities = 23/178 (12%), Positives = 56/178 (31%), Gaps = 33/178 (18%) Query: 161 GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA-RYLLVKSLDGVVKIWDCI 219 G +++ D K ++ + ++ VK+ + LV G + +++ Sbjct: 125 GQVQLIDPIKKETSKLFNEERLIDKSR----VTCVKWVPGSESLFLVAHSSGNMYLYNVE 180 Query: 220 GGC--------------------VVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 259 C PL K + +F DG + Sbjct: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDG--KFLACV 238 Query: 260 YENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI--HCFGNIMCSLALNGDCCLWRWV 315 ++G + +N D+ L G++ + ++ + G + + + +W +V Sbjct: 239 SQDGFLRVFNFDSVE----LHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFV 292 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 23/177 (12%), Positives = 54/177 (30%), Gaps = 32/177 (18%) Query: 139 EAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG--------------------HCLKTLT 178 V V S+ G + +++ E C T Sbjct: 150 SRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKST 209 Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLH 238 + K G +++ FS + ++L S DG +++++ + T + Sbjct: 210 RNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSY-------- 261 Query: 239 HSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHC 295 + DG +++G E+ + W+ ++ G + V++ Sbjct: 262 FGGLLCVCWSPDG--KYIVTGGEDDLVTVWSFVDCRVIARGHG--HKSWVSVVAFDP 314 >5M89-A nrPDB Length = 329 Score = 74.4 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 34/200 (17%), Positives = 68/200 (34%), Gaps = 12/200 (6%) Query: 13 GLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIAT 72 G T + + + +G + +YD R + + +HA P + L P G+ +A+ Sbjct: 92 GEPVTATEWTGTKVVIGTAKGW-VKVYDAGRESAT---FQTHAGPVTGLAVHPGGRILAS 147 Query: 73 ASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMK 132 D S L G A + + F+ GNL + I ++ T + Sbjct: 148 VGVDKSFVFYDLETGERVARGYADAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAE 207 Query: 133 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 + + + ++ N ++G + IFD + +E + Sbjct: 208 SFPLGT-PIQALAFSENGFWFAATGKGTSSVTIFDLRK-------SGAAAAVKELQTGEV 259 Query: 193 SQVKFSENARYLLVKSLDGV 212 + + +YL GV Sbjct: 260 LSISWDYTGQYLATGGGTGV 279 Score = 47.4 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 17/113 (15%), Positives = 39/113 (34%), Gaps = 3/113 (2%) Query: 13 GLKATCAKISPDGQFLAITQGLN--ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI 70 G S +G + A T + I+D+ + + + + W GQ + Sbjct: 212 GTPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYL 271 Query: 71 ATASDDF-SVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 AT +V++ + + PV+ + + + L S + + + Sbjct: 272 ATGGGTGVTVQMYTKATKSWSEPVRLGMPVVGVKWGGEAKRLVVVSREGVVSV 324 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 23/146 (15%), Positives = 44/146 (30%), Gaps = 14/146 (9%) Query: 112 FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 171 +D + I+ + + +T+ E V + + + + G+ G ++++DA G Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDI-GEPVTATEWT---GTKVVIGTAKGWVKVYDA--G 120 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQP 231 T P++ + R L +D +D G V Sbjct: 121 RESATFQTHAG--------PVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYADA 172 Query: 232 LEKGVLHHSCGMDFLNPEDGSTPLVI 257 H G F LV Sbjct: 173 ALTTCAFHPDGNLFAAGTQTGHILVF 198 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 19/158 (12%), Positives = 50/158 (31%), Gaps = 26/158 (16%) Query: 155 SSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVK 214 + G DG + I+ +TL + P++ +++ +++ + G VK Sbjct: 67 AVGGLDGKLDIYSVVANKVERTL---------DIGEPVTATEWT--GTKVVIGTAKGWVK 115 Query: 215 IWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS 274 ++D P+ +H ++ S + ++ +T Sbjct: 116 VYDAGRESATFQTHAGPVTGLAVHP------------GGRILASVGVDKSFVFYDLETGE 163 Query: 275 LLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 + + + H GN+ + G ++ Sbjct: 164 RVARGYADAALTT---CAFHPDGNLFAAGTQTGHILVF 198 >3F3P-A nrPDB Length = 351 Score = 74.0 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 42/287 (14%), Positives = 105/287 (36%), Gaps = 31/287 (10%) Query: 47 SQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHL-----SYGLLHTFIGHTAPVIS 101 Q + H ++ + G+ +AT S D +++ L ++ L ++ H + +++ Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 102 LTFN--RKGNLLFTSSMDESIKIW--DTLNGSLMK-------TISAHSEAVVSVDVPMND 150 + + G ++ ++S D+++K+W D T++ ++ SV Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 151 -SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK-----RENGVVPISQVKFSE---NA 201 L+ DG++R++DA L++ T + K N + + + + Sbjct: 123 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 182 Query: 202 RYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE 261 L V +L+ + I+ + P K ++ + + L+ +G + Sbjct: 183 EKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIR---SISWAPSIGRWYQLIATGCK 238 Query: 262 NGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGD 308 +G I + L L +S + ++ + + Sbjct: 239 DGRIRIF--KITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSN 283 Score = 71.7 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 43/251 (17%), Positives = 94/251 (37%), Gaps = 44/251 (17%) Query: 94 GHTAPVISLTFNRKGNLLFTSSMDESIKIW----DTLNGSLMKTISAHSEAVVSVDVPMN 149 GH V + ++ G + T S D+ IK++ DT N L + AH ++V++D Sbjct: 9 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 68 Query: 150 D-SSILSSGSYDGLIRIF--DAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN--ARYL 204 + I++S SYD ++++ D + C ++K + + VKF+ L Sbjct: 69 EYGRIIASASYDKTVKLWEEDPDQEECSGR-RWNKLCTLNDSKGSLYSVKFAPAHLGLKL 127 Query: 205 LVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSC----------------GMDFLNP 248 DG+++++D + +R++ + K + + L Sbjct: 128 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 187 Query: 249 EDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNI------MCS 302 ++ ++G ++ L H S + SI +I + + Sbjct: 188 SALEQAIIYQRGKDGKLHV------------AAKLPGHKSLIRSISWAPSIGRWYQLIAT 235 Query: 303 LALNGDCCLWR 313 +G +++ Sbjct: 236 GCKDGRIRIFK 246 Score = 52.1 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 82/239 (34%), Gaps = 38/239 (15%) Query: 10 TQNGLKATCAKISPD--GQFLAITQGLNI-LIYD------INRRTVSQTLVT------SH 54 + K +P G LA I +YD + T++ + +H Sbjct: 107 NDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANH 166 Query: 55 ARPFSELCWSPD---GQCIATASDDFSVEIIHLSYGLLH---TFIGHTAPVISLTFNR-- 106 + L W P + +A ++ + ++ G LH GH + + S+++ Sbjct: 167 LQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSI 226 Query: 107 --KGNLLFTSSMDESIKIWD-TLNGSLM---KTISAHSEAVVSVDVPMNDSSILSSGSYD 160 L+ T D I+I+ T S + ++++ + S DV M+ S Sbjct: 227 GRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGR----SDS 282 Query: 161 GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI 219 + ++ ++ L+ D + V ++ L DG V++W Sbjct: 283 NTEEKAELQSNLQVELLSEHDD-----HNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 336 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 53/176 (30%), Gaps = 56/176 (31%) Query: 14 LKATC-AKISPDGQFLAITQGLNILIYDINRRTV--SQTLVTSHARPFSELCWSPDG--- 67 + C ++ SP+ LA++ +IY + + H + W+P Sbjct: 172 CLSWCPSRFSPEK--LAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRW 229 Query: 68 -QCIATASDDFSVEII-------------------------------------------- 82 Q IAT D + I Sbjct: 230 YQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAE 289 Query: 83 ---HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTIS 135 +L LL H V S+++N G +L ++ D +++W + K +S Sbjct: 290 LQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMS 345 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 43/302 (14%), Positives = 95/302 (31%), Gaps = 51/302 (16%) Query: 13 GLKATCAKI---SPD-GQFLAITQ-GLNILIYDIN--------RRTVSQTLVTSHARPFS 59 ++ I SP+ G+ +A + +++ + RR + Sbjct: 55 AHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLY 114 Query: 60 ELCWSPD--GQCIATASDDFSVEIIH-LSYGLLHTFI-------------GHTAPVISLT 103 + ++P G +A +D + + L L ++ H L+ Sbjct: 115 SVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLS 174 Query: 104 FNRK---GNLLFTSSMDESIKIWDTLNGSLM--KTISAHSEAVVSVDVPMNDS---SILS 155 + L S+++++I +G L + H + S+ + +++ Sbjct: 175 WCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIA 234 Query: 156 SGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 +G DG IRIF L L ++ N + V R S Sbjct: 235 TGCKDGRIRIFKI--TEKLSPLASEESLTNSNMFDNSADVDMDAQGR-----SDSNT--- 284 Query: 216 WDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSL 275 + QV+ L + H+ G+ ++ S ++G + W + + Sbjct: 285 --EEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT--ILSSAGDDGKVRLWKATYSNE 340 Query: 276 LQ 277 + Sbjct: 341 FK 342 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 10/90 (11%), Positives = 24/90 (26%), Gaps = 4/90 (4%) Query: 180 DKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHH 239 + V + R++ S D +K++ T + + H Sbjct: 2 HMQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKD----TSNWELSDSWRAHD 57 Query: 240 SCGMDFLNPEDGSTPLVISGYENGDIYCWN 269 S + ++ S + + W Sbjct: 58 SSIVAIDWASPEYGRIIASASYDKTVKLWE 87 >5A9Q-2 nrPDB Length = 326 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 33/231 (14%), Positives = 78/231 (33%), Gaps = 38/231 (16%) Query: 55 ARPFSELCWSP-----DGQCIATASDDFSV-----------EIIHLSYGLLHTFIGHTAP 98 + ++P G IA +++ V ++ + Y L TF H Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFH-HGVR 74 Query: 99 VISLTFNRKGNL--------LFTSSMDESIKIW--DTLNGSLMKTISAHSEAVVSVDVPM 148 V + ++ + L TS+ D I+++ D + + K + H++ + + Sbjct: 75 VDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDP 134 Query: 149 NDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARY-LLVK 207 + ++S S D RI++ E + + V + + L+V Sbjct: 135 KEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGM----------SVCWHPEETFKLMVA 184 Query: 208 SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS 258 +G ++ +D + + + + + + H F +I Sbjct: 185 EKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIW 235 Score = 72.5 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 34/214 (15%), Positives = 84/214 (39%), Gaps = 15/214 (7%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQ---------FLAITQGLNILIYDINRRTVSQT-LV 51 Q+ T +G++ SP+ + F + I ++ + + ++ ++ Sbjct: 61 IQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVL 120 Query: 52 TSHARPFSELCWSP-DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNL 110 H + L + P +GQ IA+ SDD + I +L F+ H +P +S+ ++ + Sbjct: 121 EGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLH-SPGMSVCWHPEETF 179 Query: 111 -LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA- 168 L + + +I+ +D L + ++ + ++S + ++ + + + I+D Sbjct: 180 KLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAG-NDWLIWDIT 238 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR 202 + + D IS+ F+ Sbjct: 239 RSSYPQNKRPVHMDRACLFRWSTISENLFATTGY 272 Score = 70.6 bits (171), Expect = 9e-13, Method: Composition-based stats. Identities = 43/270 (15%), Positives = 78/270 (28%), Gaps = 43/270 (15%) Query: 18 CAKISP-----DGQFLAITQGLNILI---------YDINRRTVSQTLVTSHARPFSELCW 63 + +P G +A ++I D+ H + W Sbjct: 21 VVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAW 80 Query: 64 SPDGQC--------IATASDDFSVEIIHL---SYGLLHTFIGHTAPVISLTFNR-KGNLL 111 SP+ + T++ D + + GHT + L F+ +G + Sbjct: 81 SPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEI 140 Query: 112 FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 171 + S D + +IW+ HS +SV ++ L +G IR +D Sbjct: 141 ASVSDDHTCRIWNLEGVQTAH-FVLHS-PGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQ 198 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQP 231 + +L ++ + K V D ++ WD T P Sbjct: 199 QAILSLESEQVPLMSAHWCLKNTFKVG------AVAGNDWLI--WDI-------TRSSYP 243 Query: 232 LEKGVLHHSCGMDFLNPEDGSTPLVISGYE 261 K +H F +GY Sbjct: 244 QNKRPVHMDRACLFRWSTISENLFATTGYP 273 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 17/135 (12%), Positives = 39/135 (28%), Gaps = 20/135 (14%) Query: 187 NGVVPISQVKFSENAR--------YLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLH 238 + V + + +S R + D ++++ Q + K + Sbjct: 70 HHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLF-------TSDLQDKNEYKVLEG 122 Query: 239 HSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN 298 H+ ++ L + + S ++ WN +Q L+ V H Sbjct: 123 HTDFINGLVFDPKEGQEIASVSDDHTCRIWNL---EGVQTAHFVLHSPGMSVC-WHPEET 178 Query: 299 I-MCSLALNGDCCLW 312 + NG + Sbjct: 179 FKLMVAEKNGTIRFY 193 >5WLC-LN nrPDB Length = 776 Score = 72.1 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 51/311 (16%), Positives = 99/311 (31%), Gaps = 36/311 (11%) Query: 17 TCAKISPDGQFLAITQGL-NILIYDINRRTVS---QTLVTSHARPFSELCWSPDGQCIAT 72 I+ L++ +++ DI+ T++ L W D I Sbjct: 145 WSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGG 204 Query: 73 ASDDFSVEIIHLSYGLLHT-FIGHTAPV----------ISLTFNRKGNLLFTSSMDESIK 121 S D + I + + HT V S+ + + + + + SIK Sbjct: 205 CS-DGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIK 263 Query: 122 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 181 WD +L ++ AH V+ + +++ + S+G D I F T K + Sbjct: 264 FWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAG-VDRKIFQFSQNTNKSQKNNRWVN 322 Query: 182 DWKRENGVVPISQVKF--SENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHH 239 R I + S+ A +L+ ++ + I + +F K Sbjct: 323 SSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVI------NSLTSFSNGNYRKMPTVE 376 Query: 240 SCGMDFLNPEDGSTPLVISGYENGDIYCWNSDT-------KSLLQLLDGSLYHHSSPVMS 292 + L + LV+S E+ + W T L+ L + S Sbjct: 377 PYSKNVLVNK--EQRLVVSWSES-TVKIWTMGTDSSTEQNYKLVCKL-TLKDDQNISTCS 432 Query: 293 IHCFGNIMCSL 303 + G ++ Sbjct: 433 LSPDGQVLVVG 443 Score = 72.1 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 46/271 (16%), Positives = 99/271 (36%), Gaps = 30/271 (11%) Query: 49 TLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG---LLHTFIGHTAPVISLTFN 105 +L SH ++L +P +A + ++EI + + G + L ++ Sbjct: 48 SLAFSHKSNINKL--TPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWS 105 Query: 106 R---KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGL 162 + LF+ + WD G ++ +S + S+ + + LS G +G Sbjct: 106 NVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDK-LSVGCDNGT 164 Query: 163 IRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIW-----D 217 + + D G + + D + + + ++ +++ DG ++IW D Sbjct: 165 VVLIDISGGPGVL----EHDTILMRQEARVLTLAWKKDD-FVIGGCSDGRIRIWSAQKND 219 Query: 218 CIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQ 277 G ++ T +V +K + +L D + SG G I W+ Sbjct: 220 ENMGRLLHTMKVDKAKKESTLV-WSVIYLPRTD----QIASGDSTGSIKFWDFQ----FA 270 Query: 278 LLDGSLYHHSSPVMSI--HCFGNIMCSLALN 306 L+ S H + V+ + N + S ++ Sbjct: 271 TLNQSFKAHDADVLCLTTDTDNNYVFSAGVD 301 Score = 65.9 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 50/314 (15%), Positives = 95/314 (30%), Gaps = 28/314 (8%) Query: 18 CAKISPDGQFLAITQGLNILIYDINR-----RTVSQTLVTSHARPFSELCWS----PDGQ 68 D + I I+ + + T+ A+ S L WS P Sbjct: 192 TLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTD 251 Query: 69 CIATASDDFSVEIIHLSYGLLHT-FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLN 127 IA+ S++ + L+ F H A V+ LT + N +F++ +D I + Sbjct: 252 QIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNT 311 Query: 128 GSLMKT--------ISAHSEAVVS-VDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLT 178 K H + + + L SG + + I + L + + Sbjct: 312 NKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVI------NSLTSFS 365 Query: 179 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDC-IGGCVVRTFQVQPLEKGVL 237 K V ++ R ++ S VKIW + +++ Sbjct: 366 NGNYRKMPTVEPYSKNVLVNKEQRLVVSWSE-STVKIWTMGTDSSTEQNYKLVCKLTLKD 424 Query: 238 HHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFG 297 + L+P DG +V + K + LD L +S + Sbjct: 425 DQNISTCSLSP-DGQVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDLLLRTSTKLVKFIDN 483 Query: 298 NIMCSLALNGDCCL 311 + + + D + Sbjct: 484 SKIVICSCEDDVFI 497 >5YZG-2 nrPDB Length = 646 Score = 72.1 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 35/249 (14%), Positives = 82/249 (32%), Gaps = 34/249 (13%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHL---SYGLLHTFIGHTAPVISLTFNRKGNL 110 H + + + I TAS D V+ + F H + S+ + +G L Sbjct: 89 HRDVITHVVCTKT-DFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGAL 147 Query: 111 LFTSSMDESIKIWDTLNGSLMKT-----ISAHSEAVVSVDVPMNDSSILSSGSYDGL--I 163 + D+++K++D +N ++ E + D+ + S I Sbjct: 148 FCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC----PGDAISSVAASEKSTGKI 203 Query: 164 RIFDAETG-HCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGC 222 I+D L + P++Q++ + + ++ G+++ W G Sbjct: 204 FIYDGRGDNQPLHIF-------DKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYW--TGPP 254 Query: 223 VVRTFQVQPLEKGVLHHSCGMDFLNPE--------DGSTPLVISGYENGDIYCWNSDTKS 274 F + + + +F + + + + + + T Sbjct: 255 HEYKF-PKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGK 313 Query: 275 LLQLLDGSL 283 L+++ D SL Sbjct: 314 LMRVFDESL 322 Score = 59.8 bits (143), Expect = 1e-09, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 76/232 (32%), Gaps = 21/232 (9%) Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG--SLMKTISAHSEAVVSVDVPMNDSS 152 H + + K + + T+S D +K W + +K +H + S+ V + + Sbjct: 89 HRDVITHVV-CTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSS-EGA 146 Query: 153 ILSSGSYDGLIRIFDAETGHCLKT-----LTYDKDWKRENGVVPISQVKFSENAR---YL 204 + S D +++FD + +W G IS V SE + ++ Sbjct: 147 LFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPG-DAISSVAASEKSTGKIFI 205 Query: 205 LVKSLDGV-VKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENG 263 D + I+D + + ++ P+ K V+ N Sbjct: 206 YDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVN- 264 Query: 264 DIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWRWV 315 W T + L + + V G + ++ + ++R+V Sbjct: 265 ----WEYKTDTDLYEF-AKCKAYPTSVC-FSPDGKKIATIGSDRKVRIFRFV 310 Score = 59.4 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 29/191 (15%), Positives = 68/191 (35%), Gaps = 18/191 (9%) Query: 124 DTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDW 183 + + S+ + H + + V D + + S+DG ++ + + + + K + Sbjct: 76 NLPSASMYERSYMHRDVITHVVCTKTD--FIITASHDGHVKFW----KKIEEGIEFVKHF 129 Query: 184 KRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGM 243 + GV I + S D +K++D + ++ ++ C Sbjct: 130 RSHLGV--IESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC-- 185 Query: 244 DFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPV--MSIHCFGNIMC 301 P D + + S G I+ ++ + Q L H+SP+ + ++ + Sbjct: 186 ----PGDAISSVAASEKSTGKIFIYDGRGDN--QPLHIFDKLHTSPLTQIRLNPVYKAVV 239 Query: 302 SLALNGDCCLW 312 S +G W Sbjct: 240 SSDKSGMIEYW 250 >5A9Q-0 nrPDB Length = 380 Score = 72.1 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 25/194 (12%), Positives = 70/194 (36%), Gaps = 10/194 (5%) Query: 23 PDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII 82 + + + + + I ++ + + +T+ + + + + + + S ++I Sbjct: 140 NNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSI-GQLKIW 198 Query: 83 HLSY-----GLLHTFIGHTAPVISLTFNRKG-NLLFTSSMDESIKIWDTLNGS-LMKTIS 135 + + G P+ + + +++ T D + IWD G+ + + Sbjct: 199 DFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLK 258 Query: 136 AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQV 195 AH + V ++ L + S DG + +DA T K+ + + + + + Sbjct: 259 AHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLS--HSI 316 Query: 196 KFSENARYLLVKSL 209 N ++ S Sbjct: 317 SNQANVHQSVISSW 330 Score = 61.3 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 87/253 (34%), Gaps = 25/253 (9%) Query: 2 FQFVTPVGTQNGLKATCAKI---SPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPF 58 QF C + P+ Q L++ Q Y + S + + P Sbjct: 80 LQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYS-----SAPC 134 Query: 59 SELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFI--GHTAPVISLTFNRKGNLLFTSSM 116 + + + I T +D + + + I ++ + ++TF R +L +S+ Sbjct: 135 TGVVC--NNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSI 192 Query: 117 DESIKIWDTLN----GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 +KIWD S + +++ + VD N ++++G DG++ I+D G Sbjct: 193 -GQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGT 251 Query: 173 -CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQP 231 + L + E P N +L S DG + WD ++ Sbjct: 252 MPVSLLKAHEAEMWEVHFHP-------SNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQ 304 Query: 232 LEKGVLHHSCGMD 244 + S + Sbjct: 305 GGRSSTFLSHSIS 317 Score = 59.8 bits (143), Expect = 1e-09, Method: Composition-based stats. Identities = 44/264 (16%), Positives = 86/264 (32%), Gaps = 38/264 (14%) Query: 54 HARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLL-------HTFIGHT---------A 97 H +L + + +A +S +H T HT A Sbjct: 73 HHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSA 132 Query: 98 PVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSG 157 P + N + T D I ++ + ++TI + + + IL+ Sbjct: 133 PCTGVVCNNPE--IVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVN 190 Query: 158 SYDGLIRIFDAET--GHCLKTLTYDKDWKRENGVVPISQVKFSENARYLL-VKSLDGVVK 214 S G ++I+D + L+ D VP+ V N ++++ DG++ Sbjct: 191 SI-GQLKIWDFRQQGNEPSQILSLTGDR------VPLHCVDRHPNQQHVVATGGQDGMLS 243 Query: 215 IWDCIGGCV-VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTK 273 IWD G + V + E +H + + + E+G ++ W++ T Sbjct: 244 IWDVRQGTMPVSLLKAHEAEMWEVHFHPS---------NPEHLFTCSEDGSLWHWDASTD 294 Query: 274 SLLQLLDGSLYHHSSPVMSIHCFG 297 + SS +S Sbjct: 295 VPEKSSLFHQGGRSSTFLSHSISN 318 Score = 47.4 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 50/299 (16%), Positives = 105/299 (35%), Gaps = 58/299 (19%) Query: 55 ARPFSELCWSP-------DGQCIATASDDFS---VEIIHL-SYGLLHT---FIG------ 94 ++ S+ W P + AT S D + + + +G L + F G Sbjct: 10 SQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLC 69 Query: 95 ---HTAPVISLTFNRKGNLLFTSSMDE-SIKIWDTLN-----GSLMKTISAHS------- 138 H V+ L F + ++ SS ++ + N T H+ Sbjct: 70 DIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSY 129 Query: 139 EAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFS 198 + V N+ I++ G DG I +F A+ ++T+ D + + ++ ++ Sbjct: 130 SSAPCTGVVCNNPEIVTVG-EDGRINLFRADHKEAVRTI----DNADSSTLHAVTFLRTP 184 Query: 199 ENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS 258 E +L + G +KIWD + + ++ +V + Sbjct: 185 E----ILTVNSIGQLKIWDFRQQGNE-----PSQILSLTGDRVPLHCVDRHPNQQHVVAT 235 Query: 259 GYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN---IMCSLALNGDCCLWRW 314 G ++G + W+ ++ L L H + + +H + + + + +G LW W Sbjct: 236 GGQDGMLSIWDVRQGTMPVSL---LKAHEAEMWEVHFHPSNPEHLFTCSEDGS--LWHW 289 >2P9P-C nrPDB Length = 372 Score = 71.3 bits (173), Expect = 4e-13, Method: Composition-based stats. Identities = 38/267 (14%), Positives = 77/267 (28%), Gaps = 32/267 (11%) Query: 56 RPFSELCWSPDGQCIATASDDFSVEIIHLSYG---LLHTFIGHTAPVISLTFNRKGNLLF 112 P S W+ D IA ++ V I S +H H V + + N + Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 113 TSSMDESIKIWDTLNGSLMKTI-SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 171 T D + +W + T+ + + GS +I I Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISI------ 122 Query: 172 HCLKTLTYDKDWKRENGV-----VPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 C + DW + + + + N+ L S D +I+ V Sbjct: 123 -CY--FEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEER 179 Query: 227 FQVQP----LEKGVLHHSCGMDFLNPED----GSTPLVISGYENGDIYCWNSDTKSLLQL 278 P + G L + V + + ++D K + Sbjct: 180 PAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAV-- 237 Query: 279 LDGSLYHHSSPVMSIHC--FGNIMCSL 303 +L + P++++ +++ + Sbjct: 238 --ATLASETLPLLAVTFITESSLVAAG 262 Score = 64.0 bits (154), Expect = 8e-11, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 79/263 (30%), Gaps = 20/263 (7%) Query: 15 KATCAKISPDGQFLAIT-QGLNILIYD-INRRTVSQTLVTSHARPFSELCWSPDGQCIAT 72 +C + D +AI + IY+ + V + H + + W+PD I T Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 73 ASDDFSVEIIHLS---YGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS 129 D + + L + + + + S I I + Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 130 ----LMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLT------- 178 V+S+D N S +L++GS D RIF A + Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPN-SVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSK 188 Query: 179 ---YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKG 235 + ++ + + V FS N + S D V + D V T + L Sbjct: 189 MPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLPLL 248 Query: 236 VLHHSCGMDFLNPEDGSTPLVIS 258 + + P++ + Sbjct: 249 AVTFITESSLVAAGHDCFPVLFT 271 Score = 50.9 bits (120), Expect = 6e-07, Method: Composition-based stats. Identities = 38/265 (14%), Positives = 79/265 (29%), Gaps = 62/265 (23%) Query: 16 ATCAKISPDGQFLAITQGLNILIY----DINRRTVSQTLVTSHARPFSELCWSPDGQCIA 71 A C + +P+ + A+ G ++ N V + + L W P+ +A Sbjct: 99 ARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLA 158 Query: 72 TASDDFSVEII-----HLSYGLLHTFIGHTAP--------------VISLTFNRKGNLLF 112 S DF I + T G P V + F+ G+ + Sbjct: 159 AGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVA 218 Query: 113 TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 S D ++ + D + T+++ + +++V S L + +D +F ++ Sbjct: 219 WVSHDSTVCLADADKKMAVATLASETLPLLAVTFITESS--LVAAGHDCFPVLFTYDSAA 276 Query: 173 CLKTLTYDKDWKREN---------------------------------GVVPISQVKFSE 199 + D +++ +SQ+ Sbjct: 277 GKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVLS 336 Query: 200 NAR----YLLVKSLDGVVKIWDCIG 220 + +DG + IWD Sbjct: 337 GGKAKCSQFCTTGMDGGMSIWDVRS 361 >5WLC-LW nrPDB Length = 554 Score = 70.6 bits (171), Expect = 9e-13, Method: Composition-based stats. Identities = 40/259 (15%), Positives = 79/259 (30%), Gaps = 28/259 (10%) Query: 19 AKISPDGQ-FLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 K + +G L + ++ D + + L + + Q A A + Sbjct: 116 IKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFL--NETCHSATYLQNEQYFAVAQKKY 173 Query: 78 SVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAH 137 + I LH H L F LL T+ +K D G L+ + Sbjct: 174 TF-IYDHEGTELHRLKQHIEA-RHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTK 231 Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 + +++ + +++ G +G + ++ L L + P++ + Sbjct: 232 AGPTMAMAQNPWN-AVMHLGHSNGTVSLWSPSMPEPLVKLLSARG--------PVNSIAI 282 Query: 198 SENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVL--------------HHSCGM 243 + Y+ D +KIWD + + + P + H + Sbjct: 283 DRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTGLLALSRGPHVTLWK 342 Query: 244 DFLNPEDGSTPLVISGYEN 262 D L S P S N Sbjct: 343 DALKLSGDSKPCFGSMGGN 361 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 67/212 (31%), Gaps = 27/212 (12%) Query: 102 LTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDG 161 + + + G L + + D G L + +E S N+ + + Sbjct: 116 IKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFL-NETCHSATYLQNEQYF--AVAQKK 172 Query: 162 LIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGG 221 I+D E G L L + + + F L+ G +K D G Sbjct: 173 YTFIYDHE-GTELHRLKQHIEARH---------LDFLPYHYLLVTAGETGWLKYHDVSTG 222 Query: 222 CVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKS-LLQLLD 280 +V + + + + ++ G+ NG + W+ L++LL Sbjct: 223 QLVSELRTKAGPTMAMAQNPWNAVMHL----------GHSNGTVSLWSPSMPEPLVKLLS 272 Query: 281 GSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 +S ++I G M + + +W Sbjct: 273 ARGPVNS---IAIDRSGYYMATTGADRSMKIW 301 >5CXB-B nrPDB Length = 369 Score = 69.8 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 34/167 (20%), Positives = 64/167 (38%), Gaps = 18/167 (10%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 A A P + +I YD+ + + + + A+ S P G + S Sbjct: 204 AQTASFHPLRPLFFVATQRSIRCYDLQKLELVKIVQPG-AKWISSFDVHPGGDNLVVGSY 262 Query: 76 DFSV--EIIHLSYGLLHTFIGHTAPVISLTFNRKG-NLLFTSSMDESIKIWD--TLNGS- 129 D + + LS T HT + ++ F++ G L +S D S++I+ N Sbjct: 263 DKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQL 322 Query: 130 ------LMKTISAHSE----AVVSVDVPMNDSSILSSGSYDGLIRIF 166 +K + H V+ +D + +S+G+ DG R++ Sbjct: 323 ENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGA-DGTARLW 368 Score = 60.9 bits (146), Expect = 6e-10, Method: Composition-based stats. Identities = 50/372 (13%), Positives = 103/372 (27%), Gaps = 96/372 (25%) Query: 13 GLKATCAKISPDGQFLAITQGL-NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCI- 70 + I P G LA + ++++ ++ + + + W P Sbjct: 21 EGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTKDTFI 80 Query: 71 --ATASDDFSVEI----------IHLSYGLLHTFIGH----------------------- 95 A A +D + I S +L+ GH Sbjct: 81 LAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPGKWARP 140 Query: 96 ---------------TAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEA 140 + + +++++R+G+ T S + + T+S H Sbjct: 141 GTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQ------RSSVAIHTLSKHLTQ 194 Query: 141 V---------VSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 191 + + + IR +D + +K + W Sbjct: 195 IPFRKLNGLAQTASFHPLRPLFFVA--TQRSIRCYDLQKLELVKIVQPGAKW-------- 244 Query: 192 ISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG 251 IS L+V S D + +W + K + H+ + + G Sbjct: 245 ISSFDVHPGGDNLVVGSYDKRL-LWHDLDLS-------NRPYKTMRFHTEAIRAVRFHKG 296 Query: 252 STPLVISGYENGDIYCW---------NSDTKSLLQLLDGSLYHHSSPVMSI--HCFGNIM 300 PL ++G + + + T +++L G + V+ I H Sbjct: 297 GLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWC 356 Query: 301 CSLALNGDCCLW 312 S +G LW Sbjct: 357 VSAGADGTARLW 368 Score = 54.4 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 2/69 (2%) Query: 92 FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAH-SEAVVSVDV-PMN 149 F GH V S+ + G L T D ++++W+ L G + ++ + EAV +V P Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTK 76 Query: 150 DSSILSSGS 158 D+ IL++ + Sbjct: 77 DTFILAAAA 85 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 37/283 (13%), Positives = 75/283 (26%), Gaps = 40/283 (14%) Query: 45 TVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLL---HTFIGHTAPVIS 101 TV QT+ H + P G +AT DD +V + L G G V + Sbjct: 11 TVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNT 69 Query: 102 LTFNRKGN---LLFTSSMDESIKI---------WDTLNGSLMKTISAHSEAVVSVDVPMN 149 + + + L + D + I D + ++ H+ Sbjct: 70 VRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPP 129 Query: 150 DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSL 209 + G L + R I + + + S Sbjct: 130 GKEPPGKWARPGT-------------RLEDEGVLLRITVRSTIKAISWHRRGDHFATVSP 176 Query: 210 DGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN 269 G + T + + + ++ + I C++ Sbjct: 177 SGQ------RSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQRS--IRCYD 228 Query: 270 SDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 L++++ SS +H G+ + + + LW Sbjct: 229 LQKLELVKIVQPGAKWISS--FDVHPGGDNLVVGSYDKRL-LW 268 Score = 44.7 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 14/98 (14%), Positives = 29/98 (29%), Gaps = 6/98 (6%) Query: 170 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQV 229 + LK + + V L DG V++W+ + G V + ++ Sbjct: 2 SPDELKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKL 61 Query: 230 QPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYC 267 E + P + L + E+ + Sbjct: 62 NGDE------AVNTVRWRPTKDTFILAAAAGEDIFLMI 93 >5AMS-A nrPDB Length = 431 Score = 68.2 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 46/270 (17%), Positives = 94/270 (34%), Gaps = 18/270 (6%) Query: 40 DINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLH---TFIGHT 96 +++ S T H + P+ + T D + T G+ Sbjct: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYG 109 Query: 97 APVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI--- 153 VIS +F +G L T+ M + + G +++ + V + +I Sbjct: 110 ESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIART 169 Query: 154 LSSGSYDGLIRIF--DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG 211 + G+ DG + + + + G + ++ + + I+ K EN L+ SLD Sbjct: 170 FAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDK-GENTLELVTCSLDS 228 Query: 212 VVKIWDCIGG-CVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 + W+C G + + Q + S + G++ +V G NG + N Sbjct: 229 TIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINC 288 Query: 271 DTKSLLQLLDGSLYHHSSPVMSIHCFGNIM 300 + +G H S V+ + + + Sbjct: 289 N--------NGGAILHLSTVIELKPEQDEL 310 Score = 62.5 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 76/232 (32%), Gaps = 19/232 (8%) Query: 82 IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW--DTLNGSLMKTISAHSE 139 + +S L F HT V ++ + L+ T D +W + T++ + E Sbjct: 51 VDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGE 110 Query: 140 AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF-- 197 +V+S L + G + + + G WK + + + ++ + Sbjct: 111 SVISCSFTSEGG-FLVTADMSGKVLVHMGQKG--------GAQWKLASQMQEVEEIVWLK 161 Query: 198 --SENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 AR + DG V W + + +F+N + G L Sbjct: 162 THPTIARTFAFGATDGSV--WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTL 219 Query: 256 -VISGYENGDIYCWNSDTK-SLLQLLDGSLYHHSSPVMSIHCFGNIMCSLAL 305 +++ + I WN T L ++ + +P +S+ + Sbjct: 220 ELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNS 271 >3JB9-S nrPDB Length = 488 Score = 66.7 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 33/172 (19%), Positives = 64/172 (37%), Gaps = 6/172 (3%) Query: 58 FSELCWSPDGQCIATASDDFSVEIIHLSYGLLH-TFIGHTAPVISLTFNRKGNLLFTSSM 116 + L P G+ + AS + I L + + T H + SL + GNL Sbjct: 298 VNFLQAHPSGEYLLAAS-NEKCYIFSLKSQVYNITVAQH---ITSLAVHPDGNLFVAGLE 353 Query: 117 DESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKT 176 + ++ ++T +G+ + HS V ++ N ++ + + D I I+D ++ Sbjct: 354 NGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQK 413 Query: 177 LTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 + + SQ+ S + L V K W C+ V + Sbjct: 414 IPLQTK-VAAVSLDITSQLLVSSDGETLYVHIYVKSSKSWRCMSQTHVSSIS 464 Score = 61.3 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 99/292 (33%), Gaps = 35/292 (11%) Query: 1 MFQFVTPVGTQNGLKATCAKISP---DGQFLAITQGLNILIYDINRRTVSQTLVTSHARP 57 + Q +N + P + F+ +L DI + + S Sbjct: 195 LLQATPSTILENLETESTTSFFPSPENSSFVLCLHKDELLCLDIQSNSTLKIFEGSA--- 251 Query: 58 FSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPV---ISLTF---NRKGNLL 111 CW + +D S+ +S L + T+ + + F + G L Sbjct: 252 -LACCWLTSSKIAVATADAISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYL 310 Query: 112 FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 171 +S ++ I+ + T++ H + S+ V D ++ +G +G +R F+ +G Sbjct: 311 LAASNEK-CYIFSLKSQVYNITVAQH---ITSLAVHP-DGNLFVAGLENGELRFFETSSG 365 Query: 172 HCLKTLTYDKDWKRENGVVPISQVKFSENARYLL-VKSLDGVVKIWDCIGGCVVRTFQVQ 230 + L P+ ++F EN +L+ + D + IWD +V+ +Q Sbjct: 366 NELTKFGPHS--------SPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQ 417 Query: 231 PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGS 282 + L DG T V IY +S + + S Sbjct: 418 TKV-AAVSLDITSQLLVSSDGETLYV-------HIYVKSSKSWRCMSQTHVS 461 Score = 32.8 bits (73), Expect = 0.18, Method: Composition-based stats. Identities = 26/176 (14%), Positives = 59/176 (33%), Gaps = 23/176 (13%) Query: 137 HSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK 196 +E+ S +SS + D L+ + D ++ LK ++ Sbjct: 208 ETESTTSFFPSPENSSFVLCLHKDELLCL-DIQSNSTLKIFEG-----SALACCWLTS-- 259 Query: 197 FSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLV 256 + V + D + I++ +P + +P G L Sbjct: 260 -----SKIAVATADA-ISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPS-GEYLLA 312 Query: 257 ISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 S N Y ++ + Q+ + ++ H + +++H GN+ + NG+ + Sbjct: 313 AS---NEKCYIFSLKS----QVYNITVAQHITS-LAVHPDGNLFVAGLENGELRFF 360 >3I2N-A nrPDB Length = 357 Score = 64.4 bits (155), Expect = 6e-11, Method: Composition-based stats. Identities = 37/229 (16%), Positives = 81/229 (35%), Gaps = 13/229 (5%) Query: 93 IGHTAPVISLTFNRKGNLLFTSSM----DESIKIWDTLNG--SLMKTISAHSEAVVSVDV 146 G V + T I++++ +G L++ I ++ + Sbjct: 15 KGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEK-AKPIKCGTF 73 Query: 147 --PMNDSSILSSGSYDGLIRIFDAETGH-CLKTLTYDKDWKRENGVVPISQVKFSENARY 203 L++G + G + I++ E + ++ K+ + + E A Sbjct: 74 GATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIG--EGAPE 131 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENG 263 ++ S DG VK+WD ++P++ + F N + +V +GY+NG Sbjct: 132 IVTGSRDGTVKVWDPRQKD-DPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNG 190 Query: 264 DIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 DI ++ +L + S N + + +L G ++ Sbjct: 191 DIKLFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVF 239 Score = 62.1 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 41/290 (14%), Positives = 88/290 (30%), Gaps = 37/290 (12%) Query: 11 QNGLKATCAKI---SPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPD 66 + C S ++LA G N+ I+++ + V H + + Sbjct: 63 EKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGG 122 Query: 67 GQC------IATASDDFSVEIIHLSY------GLLHTFIGHTAPVISLTF----NRKGNL 110 I T S D +V++ + + ++ F N++ + Sbjct: 123 LGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERV 182 Query: 111 LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMND--SSILSSGSYDGLIRIFDA 168 + + IK++D N ++ + V S++ D + L + S +G +FD Sbjct: 183 VCAGYDNGDIKLFDLRN-MALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDM 241 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENAR-YLLVKSLDGVVKIWDCIGGCVVRTF 227 T H K + + QV+ R L G + +W Sbjct: 242 RTQHPTKGFAS---VSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKK 298 Query: 228 QVQPLE----------KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYC 267 + +E + V + + L+ L + + + Sbjct: 299 DSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 >3EI3-B nrPDB Length = 383 Score = 64.0 bits (154), Expect = 9e-11, Method: Composition-based stats. Identities = 33/315 (10%), Positives = 104/315 (33%), Gaps = 28/315 (8%) Query: 15 KATCAKISPD-GQFLAITQ-GLNILIYDINRRTVSQTLVT-SHARPFSELCWSP-DGQCI 70 + T + P +A+ G +I+++D + + + + + + ++ + + Sbjct: 75 RVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQL 134 Query: 71 ATASDDFSVEIIHLSYGLLHTFIGHTAPVI---SLTFNRKGNLLFTSSMDESIKIWDTLN 127 +S + + S ++ F + + + +L T + + Sbjct: 135 FVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDG 194 Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN 187 + K H V + ++++ S D ++++D + + Sbjct: 195 HEIFKE-KLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAE-----MP 248 Query: 188 GVVPISQVKFSE-NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 246 P++ F+ ++ LL ++++ + P + H + Sbjct: 249 HEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHP-HRQFQHLTPIKATW 307 Query: 247 NPEDGSTPLVISG-YEN--------GDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFG 297 +P L+++G Y + I +++++ L+ L + G Sbjct: 308 HPM---YDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTG 364 Query: 298 NIMCSLALNGDCCLW 312 +++ S + + +W Sbjct: 365 DVLASG-MGFNILIW 378 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 33/222 (14%), Positives = 65/222 (29%), Gaps = 46/222 (20%) Query: 85 SYGLLHTFIGHTAPVISLTFNRKG-NLLFTSSMDESIKIW--DTLNGSLMKTISAHSEAV 141 SY L T V SL ++ + S I +W D N + +A+ Sbjct: 62 SYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAI 121 Query: 142 VSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDW------------------ 183 + +++ L S G + D +G ++ W Sbjct: 122 TGMKFNQFNTNQLFVSSIRGATTLRDF-SGSVIQVFAKTDSWDYWYCCVDVSVSRQMLAT 180 Query: 184 ------------------KRENGVVPISQVKFSENARYL-LVKSLDGVVKIWDCIGGCVV 224 K + ++ +F+ +L S+D VK+WD Sbjct: 181 GDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDK 240 Query: 225 RTF-----QVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE 261 ++ +P+ + + L + + V S Y+ Sbjct: 241 NSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYD 282 Score = 31.3 bits (69), Expect = 0.53, Method: Composition-based stats. Identities = 29/193 (15%), Positives = 65/193 (33%), Gaps = 19/193 (9%) Query: 122 IWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDK 181 I + L +T S V S++ + ++ GS G I ++D + + + Sbjct: 57 IRSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQG-- 114 Query: 182 DWKRENGVVPISQVKFSE-NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS 240 I+ +KF++ N L V S+ G + D G + + + Sbjct: 115 ----MGPGDAITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVD 170 Query: 241 CGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGN-I 299 + S ++ +G G + D + + L+ + + + Sbjct: 171 VSV--------SRQMLATGDSTGRLLLLGLDGHEIFK---EKLHKAKVTHAEFNPRCDWL 219 Query: 300 MCSLALNGDCCLW 312 M + +++ LW Sbjct: 220 MATSSVDATVKLW 232 Score = 30.1 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 11/31 (35%), Positives = 14/31 (45%) Query: 10 TQNGLKATCAKISPDGQFLAITQGLNILIYD 40 + K SP G LA G NILI++ Sbjct: 349 PNAAGIISLNKFSPTGDVLASGMGFNILIWN 379 >5MC6-j nrPDB Length = 397 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 53/148 (35%), Gaps = 22/148 (14%) Query: 16 ATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHA-----RPFSELCWSPDGQCI 70 AT IS G + I +++ + H+ + +SP G + Sbjct: 189 ATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLL 248 Query: 71 ATASDDFS---VEIIHLSYGLLHT--------------FIGHTAPVISLTFNRKGNLLFT 113 A A D S + + +G H++ V+SL+FN G L + Sbjct: 249 AIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCS 308 Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAV 141 + D ++ WD + T++ H + + Sbjct: 309 AGWDGKLRFWDVKTKERITTLNMHCDDI 336 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 36/151 (23%), Positives = 66/151 (43%), Gaps = 25/151 (16%) Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSY--GLLHTFIGHTA-----PVISLTFNRK 107 ++ + + S G IAT ++ +V+I LS L + H+ + S+ F+ + Sbjct: 186 SQFATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQ 244 Query: 108 GNLLFTSSMDES---IKIWDTLNGSLMKTIS-------------AHSEAVVSVDVPMNDS 151 G+LL + S I +++T G + ++S AHS V+S+ + Sbjct: 245 GSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFN-DSG 303 Query: 152 SILSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 L S +DG +R +D +T + TL D Sbjct: 304 ETLCSAGWDGKLRFWDVKTKERITTLNMHCD 334 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 31/173 (17%), Positives = 61/173 (35%), Gaps = 14/173 (8%) Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 S+ SVD+ ++++G +G ++I + T L N I VKF Sbjct: 186 SQFATSVDISERG--LIATGFNNGTVQISELSTLRPLYNFESQHSMI--NNSNSIRSVKF 241 Query: 198 SENARYLLVKSLDGV---VKIWDCIGGCVVRTFQVQPLEK----GVLHHSCGMDFLNPED 250 S L + + +++ G + + V G HS + L+ D Sbjct: 242 SPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFND 301 Query: 251 GSTPLVISGYENGDIYCWNSDTKSLLQLL--DGSLYHHSSPVMSIHCFGNIMC 301 S + S +G + W+ TK + L ++++ G+ + Sbjct: 302 -SGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIEIEEDILAVDEHGDSLA 353 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 23/146 (15%), Positives = 56/146 (38%), Gaps = 18/146 (12%) Query: 100 ISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAH------SEAVVSVDVPMNDSSI 153 S+ + +G L+ T + +++I + + + S ++ SV S Sbjct: 190 TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGS-- 246 Query: 154 LSSGSYD----GLIRIFDAETGHCLKTLTYDKDWKREN-----GVVPISQVKFSENARYL 204 L + ++D G I +++ E G + +L+ + + + + F+++ L Sbjct: 247 LLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETL 306 Query: 205 LVKSLDGVVKIWDCIGGCVVRTFQVQ 230 DG ++ WD + T + Sbjct: 307 CSAGWDGKLRFWDVKTKERITTLNMH 332 Score = 44.0 bits (102), Expect = 8e-05, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 33/106 (31%), Gaps = 17/106 (16%) Query: 11 QNGLKATCAKISPDGQFLAITQGLN----ILIYDINRRTVSQTLVT------------SH 54 N K SP G LAI N I +Y+ +L +H Sbjct: 231 NNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAH 290 Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSY-GLLHTFIGHTAPV 99 + L ++ G+ + +A D + + + T H + Sbjct: 291 SSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 Score = 41.3 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 33/248 (13%), Positives = 77/248 (31%), Gaps = 36/248 (14%) Query: 93 IGHTAPVISLTFNRKGNLLFTSSMDESIKIWD---TLNGSLMKTISAH------SEAVVS 143 H A + S+ + + + S D +K+WD N + +H V Sbjct: 13 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 144 VDVPMNDSS---ILSSGSYDGLIRIFDA-ETGHCLKTLTYDKD-WKRENGVVPISQVKFS 198 + D+ ++++ S+ G + + K + D + +K+ Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWG 130 Query: 199 ENARYLLV---KSLD--GVVKIW---------DCIGGCVVRTFQVQPLEKGVLHHSCGMD 244 + LL + D G IW + + T ++Q + + + Sbjct: 131 ASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPM--TPSQF 188 Query: 245 FLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGS----LYHHSSPVMSIHCFGNIM 300 + + L+ +G+ NG + T L + +S + G+++ Sbjct: 189 ATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLL 248 Query: 301 CSLALNGD 308 + Sbjct: 249 AIAHDSNS 256 >3DW8-B nrPDB Length = 447 Score = 61.7 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 54/280 (19%), Positives = 97/280 (34%), Gaps = 38/280 (13%) Query: 23 PDGQFLAITQGLNILIYDINRRTVSQT-----LVTSHARPFSELCWSPDGQCIATASDDF 77 QFL T I ++ I+ R R + + + D Sbjct: 106 NAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVT---TLRVPVFRPMDL 162 Query: 78 SVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT----LNGSLMKT 133 VE + HT + S++ N ++ D I +W + +++ Sbjct: 163 MVE----ASPRRIFANAHTYHINSISINSDYETYLSA-DDLRINLWHLEITDRSFNIVDI 217 Query: 134 ISAH----SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET----GHCLKTLTYDKDWKR 185 A+ +E + + + N + S G IR+ D K +D Sbjct: 218 KPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSN 277 Query: 186 EN----GVVPISQVKFSENARYLLVKSLD-GVVKIWDC-IGGCVVRTFQVQPLEKGVLHH 239 + + IS VKFS + RY++ D VK+WD + V T+QV + L Sbjct: 278 RSFFSEIISSISDVKFSHSGRYMMT--RDYLSVKVWDLNMENRPVETYQVHEYLRSKLCS 335 Query: 240 SCGMDFLNPE-----DGSTPLVISGYENGDIYCWNSDTKS 274 D + + +GS +V++G N ++ +TK Sbjct: 336 LYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKR 375 Score = 44.4 bits (103), Expect = 6e-05, Method: Composition-based stats. Identities = 41/318 (12%), Positives = 93/318 (29%), Gaps = 74/318 (23%) Query: 29 AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII------ 82 A G N + + ++ + + A S + ++ G+ +AT V I Sbjct: 2 AGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQEN 61 Query: 83 ------HLSYGLLHTFIGHTAP------------VISLTFNRKGN--LLFTSSMDESIKI 122 Y + TF H + + + + N S+ D++IK+ Sbjct: 62 KIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKL 121 Query: 123 WD---------------------------------------TLNGSLMKTI-SAHSEAVV 142 W + S + +AH+ + Sbjct: 122 WKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHIN 181 Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENA- 201 S+ + + + LS+ D I ++ E + K E I+ +F N+ Sbjct: 182 SISINSDYETYLSA--DDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSC 239 Query: 202 RYLLVKSLDGVVKIWDCIGGCVV----RTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVI 257 + S G +++ D + + F+ S + ++ S Sbjct: 240 NTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRY 299 Query: 258 SGYENG-DIYCWNSDTKS 274 + + W+ + ++ Sbjct: 300 MMTRDYLSVKVWDLNMEN 317 Score = 32.0 bits (71), Expect = 0.37, Method: Composition-based stats. Identities = 13/91 (14%), Positives = 26/91 (28%), Gaps = 15/91 (16%) Query: 19 AKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHAR---------------PFSELCW 63 K S G+++ L++ ++D+N H E CW Sbjct: 291 VKFSHSGRYMMTRDYLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCW 350 Query: 64 SPDGQCIATASDDFSVEIIHLSYGLLHTFIG 94 + + T S + + + T Sbjct: 351 NGSDSVVMTGSYNNFFRMFDRNTKRDITLEA 381 >6IYY-A nrPDB Length = 317 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 42/246 (17%), Positives = 80/246 (32%), Gaps = 26/246 (10%) Query: 28 LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG 87 L ++I+D ++ + + + D + D +++ ++ Sbjct: 65 LVGGGKKKVMIWDDLKKKTVIEIE--FSTEVKAVKLRRDRIVVV---LDSMIKVFTFTHN 119 Query: 88 --LLHTFIGHTAPVISLTFNRKGN---LLFTSSMDESIKIWDTLNGSLMKT-ISAHSEAV 141 LH F P N L F + +++ D + I AH V Sbjct: 120 PHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEG-V 178 Query: 142 VSVDVPMNDSSILSSGSYDGL-IRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN 200 +S + +++ S G IRIFD +GH ++ L +R + I + F+++ Sbjct: 179 LSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQEL------RRGSQAANIYCINFNQD 232 Query: 201 ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY 260 A + V S G V I+ G + VI+ Sbjct: 233 ASLICVSSDHGTVHIFAAEDPK-------SKWSFSKFQVPSGSPCICAFGTEPNAVIAIC 285 Query: 261 ENGDIY 266 +G Y Sbjct: 286 ADGSYY 291 Score = 49.0 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 38/265 (14%), Positives = 87/265 (32%), Gaps = 28/265 (10%) Query: 54 HARPFSELCWSPDGQCIATASDD-FSVEIIHLSYGLLHT--FIGHTAPVISLTFNRKGNL 110 H ++ D C A ++ F V G V L R L Sbjct: 6 HGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEML--FRCNYL 63 Query: 111 LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET 170 + + IWD L + I S V +V + D ++ D +I++F Sbjct: 64 ALVGGGKKKVMIWDDLKKKTVIEIEF-STEVKAVKL-RRDRIVVV---LDSMIKVF---- 114 Query: 171 GHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ 230 T T++ + + + ++ +L + + + + V+ + Sbjct: 115 -----TFTHNP------HQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLA 163 Query: 231 PLEKGVLHHSCGMDFLNPE--DGSTPLVISGYENGD-IYCWNSDTKSLLQLLDGSLYHHS 287 EK + L+ + + + E G I +++ + L+Q L + Sbjct: 164 STEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAAN 223 Query: 288 SPVMSIHCFGNIMCSLALNGDCCLW 312 ++ + +++C + +G ++ Sbjct: 224 IYCINFNQDASLICVSSDHGTVHIF 248 >5LTD-A nrPDB Length = 525 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 41/224 (18%), Positives = 76/224 (33%), Gaps = 27/224 (12%) Query: 28 LAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG 87 L + I IYDIN + T+ T +P+G + S + + +L+Y Sbjct: 131 LVVLLEETIYIYDINNMRLLHTIETPS---------NPNGLIALSPSSENN----YLAYP 177 Query: 88 LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVP 147 P +T + + + + I+D I AH ++ ++ + Sbjct: 178 SPQKLA--PNPQTEVTLHSNPQTV----RNGDVIIFDAKTLQPTSVIEAHRTSLAAIALS 231 Query: 148 MNDSSILSSGSYDGLI-RIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLV 206 D +L++ S G I R+F TG L +R I + FS + R+++ Sbjct: 232 K-DGLLLATASDKGTIIRVFSVATGIKLYQF------RRGTYPTKIYSLAFSPDNRFVIA 284 Query: 207 KSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 250 S V I+ T + + + D Sbjct: 285 SSATETVHIFRLGEEEAANTIKSANKKARLTKAQVPNPLETSPD 328 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 23/163 (14%), Positives = 48/163 (29%), Gaps = 16/163 (9%) Query: 162 LIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF--SENARYLLVK--------SLDG 211 I I+D L T+ + + P S+ + + + L S Sbjct: 138 TIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQ 197 Query: 212 VVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDI-YCWNS 270 V+ D + +QP H + +DG L+ + + G I ++ Sbjct: 198 TVRNGDV---IIFDAKTLQPTSVIEAHRTSLAAIALSKDG--LLLATASDKGTIIRVFSV 252 Query: 271 DTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLWR 313 T L Y ++ + + + ++R Sbjct: 253 ATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFR 295 >3DWL-C nrPDB Length = 377 Score = 55.2 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 30/213 (14%), Positives = 67/213 (31%), Gaps = 29/213 (13%) Query: 26 QFLAITQGLNILIYDINR-RTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII-- 82 +F+ T + +Y+ + + H + + + W+P I T S D + + Sbjct: 25 EFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEK 84 Query: 83 --HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI---------WDTLNGSLM 131 ++ + + ++ + S I + W + + Sbjct: 85 RPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRP 144 Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDG-------LIRIFDAETGHCL--KTLTYDKD 182 ++S+D N+ +L++G D +R DA+ + L ++ Sbjct: 145 LR-----STILSLDWHPNN-VLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTV 198 Query: 183 WKRENGVVPISQVKFSENARYLLVKSLDGVVKI 215 + V FS + L D V I Sbjct: 199 CAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTI 231 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 40/129 (31%), Gaps = 22/129 (17%) Query: 16 ATCAKISPDGQFLAITQGLNILIY----DINRRTVSQTLVTSHARPFSELCWSPDGQCIA 71 AT + SP+ A+ G ++ N VS+ L L W P+ +A Sbjct: 103 ATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVLLA 162 Query: 72 TASDDFS----------------VEII--HLSYGLLHTFIGHTAPVISLTFNRKGNLLFT 113 D + L + + V ++ F+ GN L Sbjct: 163 AGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNALAY 222 Query: 114 SSMDESIKI 122 + D S+ I Sbjct: 223 AGHDSSVTI 231 Score = 38.2 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 18/146 (12%), Positives = 44/146 (30%), Gaps = 15/146 (10%) Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI-GGCVVR 225 D +T + ++ V ++ + ++ S D +++ G + Sbjct: 41 DGNGWKHARTFSDHDKI--------VTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQ 92 Query: 226 TFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYH 285 T + L + + GS VIS W +K L + L ++ Sbjct: 93 TLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDW-WVSKHLKRPLRSTILS 151 Query: 286 HSSPVMSIHCFGNIMCSLALNGDCCL 311 + H ++ + + + Sbjct: 152 -----LDWHPNNVLLAAGCADRKAYV 172 >6CVZ-A nrPDB Length = 351 Score = 54.8 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 61/330 (18%), Positives = 114/330 (34%), Gaps = 48/330 (14%) Query: 17 TCAKIS---PDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQ-CIAT 72 +C IS P FL G + + SQ + H + L +S + + + Sbjct: 37 SCLVISQPSPQASFLP---GFGVKMLSTANMKSSQ-YIPMHGKQIRGLAFSSYLRGLLLS 92 Query: 73 ASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKG-NLLFTSSMDESIKIWDTLN-GSL 130 AS D ++++ L + PV S + N ++ + SI ++D N S Sbjct: 93 ASLDNTIKLTSLETNTVVQTYNAGRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSH 152 Query: 131 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLI--RIFDAETGHCLKTLTYDKDWKRENG 188 ++ + A V + + ++ Y G++ + DA ++ W Sbjct: 153 VQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAGTLEDASFWEQKMDFSH---WPHVLP 209 Query: 189 VVPISQVKFSENA---RYLLVKSLDGV------------VKIWDCIGGCV----VRTFQV 229 + P + F L+ D ++ D V TF Sbjct: 210 LEPGGCIDFQTENSSRHCLVTYRPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFG 269 Query: 230 QPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE-NGDIYCWNSDTKSLLQLLDGSLYHHSS 288 P K + ++ F +PE+ LV +G E W++ + SLLQ L Sbjct: 270 GPTCKLLTKNAI---FQSPENDGNILVCTGDEAANSALLWDAASGSLLQDL-----QTDQ 321 Query: 289 PVMSIHCF----GNIMCSLALNGDCCLWRW 314 PV+ I F + + +L +++W Sbjct: 322 PVLDICPFEVNRNSYLATLTEK-MVHIYKW 350 >5AJA-A nrPDB Length = 361 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 41/252 (16%), Positives = 82/252 (32%), Gaps = 46/252 (18%) Query: 9 GTQNGLKATCAKISPDGQFL-AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDG 67 ++ TC S +FL T + +Y++ + H + L S DG Sbjct: 33 ANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNC-HNSAITHLEPSRDG 91 Query: 68 QCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLT--FNRKGNLLFTS-SMDESI---- 120 + T++ L G + V + F + F+ S D I Sbjct: 92 SLLLTSAT------W---SQPLSALWGMKS-VFDMKHSFTEDHYVEFSKHSQDRVIGTKG 141 Query: 121 ---KIWDTLNGSLMKTIS----AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 173 I+D G+ + T+ A++ D +L DG+ ++D + Sbjct: 142 DIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVL----NDGV--LWDVRSAQA 195 Query: 174 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 233 + K K + + F N +++ + IWD ++ T Sbjct: 196 I-----HKFDKFNMNISGV----FHPNGLEVIINTE-----IWDLRTFHLLHTVPALDQC 241 Query: 234 KGVLHHSCGMDF 245 + V +H+ + + Sbjct: 242 RVVFNHTGTVMY 253 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 24/182 (13%), Positives = 68/182 (37%), Gaps = 23/182 (12%) Query: 100 ISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSY 159 F+ + L + +K+++ +G + + H+ A+ ++ + S +L+S ++ Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATW 100 Query: 160 DGLIR-IFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDC 218 + ++ ++ + ++ V+FS++++ ++ + + I+D Sbjct: 101 SQPLSALWGMKS-----------VFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDI 149 Query: 219 IGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQL 278 G + T P +C NP D +G + W+ + + Sbjct: 150 QTGNKLLTL-FNPDLANNYKRNCAT--FNPTDDLVL------NDGVL--WDVRSAQAIHK 198 Query: 279 LD 280 D Sbjct: 199 FD 200 >5TF2-A nrPDB Length = 407 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 24/65 (36%), Gaps = 2/65 (3%) Query: 102 LTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDG 161 + FN LL T D +++W + + AH + + + + L + D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK--LVTVGRDL 235 Query: 162 LIRIF 166 ++ Sbjct: 236 KASVW 240 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 23/65 (35%), Gaps = 2/65 (3%) Query: 61 LCWSPDGQCIATASDDFSVEIIHLSY-GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDES 119 +C++ D +AT D V + + + F H + L G L T D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLK 236 Query: 120 IKIWD 124 +W Sbjct: 237 ASVWQ 241 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 35/218 (16%), Positives = 64/218 (29%), Gaps = 57/218 (26%) Query: 18 CAKISPDGQFLAITQ-GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 + D LA + ++ + +H +L PDG+ + T D Sbjct: 177 VVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFK-AHEGEIEDLALGPDGK-LVTVGRD 234 Query: 77 FSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSM-----------DE------- 118 + V L + G ++ D+ Sbjct: 235 LKASVW-----------QKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLF 283 Query: 119 SIKI---------------WDTLNGSLMKTIS-AHSEAVVSVDVPMNDSSILSSGSYDGL 162 +++I WD N ++T S H V +DV + L G+ G Sbjct: 284 TVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGHE-VVSCLDVS-ESGTFLGLGTVTGS 341 Query: 163 IRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN 200 + I+ A + CL + RE + ++ V F Sbjct: 342 VAIYIAFSLQCLY-------YVREAHGIVVTDVAFLPE 372 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 27/203 (13%), Positives = 61/203 (30%), Gaps = 31/203 (15%) Query: 125 TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 184 N ++T + S+ + V +D+++L++G DG +R++ + + + Sbjct: 159 VENLQAVQTDFS-SDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEG-- 215 Query: 185 RENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD 244 I + + + L+ D +W Q+ E G S Sbjct: 216 ------EIEDLALGPDGK-LVTVGRDLKASVW----QKDQLVTQLHWQENGPTFSSTPYR 264 Query: 245 FLNPEDGSTPLVISGYENGDIYC---------------WNSDTKSLLQLLDGSLYHHSSP 289 + G P +G + W+ L+ S H Sbjct: 265 YQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTK--SCGHEVVS 322 Query: 290 VMSIHCFGNIMCSLALNGDCCLW 312 + + G + + G ++ Sbjct: 323 CLDVSESGTFLGLGTVTGSVAIY 345 >6N8P-A nrPDB Length = 979 Score = 51.3 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 43/285 (15%), Positives = 87/285 (30%), Gaps = 44/285 (15%) Query: 42 NRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVIS 101 + ++T+ S L +SP + +A + ++++ V Sbjct: 8 DLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQ 67 Query: 102 LTFNRKGNLLFTSSMDESIKIWDT--------LNGSLMKTISA-----HSEAVVSVDVPM 148 + L T D S+ +W L T+ S ++V +P Sbjct: 68 IHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPH 127 Query: 149 NDSSILSSGSYDGLI--------RIFDAETGHCLKTLTYDKDWKRENGVVP-ISQVKFSE 199 + +L G+ G + R + T L + R V + ++ Sbjct: 128 SSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHP 187 Query: 200 -NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVIS 258 + +L+ G+V IWD Q + L + DG L++S Sbjct: 188 RDPNQILIGYSRGLVVIWD---------LQGSRVLYHFLSSQQLENIWWQRDG--RLLVS 236 Query: 259 GYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSL 303 + +G W +++ P+ S+ +G C Sbjct: 237 CHSDGSYCQWPVSSEA----------QQPEPLRSLVPYGPFPCKA 271 Score = 42.4 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 44/283 (15%), Positives = 88/283 (31%), Gaps = 49/283 (17%) Query: 23 PDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII 82 P+ + ++GL ++I+D+ V ++S + W DG+ + + D S Sbjct: 190 PNQILIGYSRGL-VVIWDLQGSRVLYHFLSSQQLE--NIWWQRDGRLLVSCHSDGSYCQW 246 Query: 83 HLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIW-DTLNGSLMKTISAHSEAV 141 +S P+ SL G + + +W T G Sbjct: 247 PVSSE-----AQQPEPLRSLV--PYGPFPCKA---ITRILWLTTRQGLPFTIFQG----- 291 Query: 142 VSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDW--------------KREN 187 + S +DG FD + T+ + D + E Sbjct: 292 -GMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEEL 350 Query: 188 GVVPISQVKFSE---------NARYLLVKSLDGVV--KIWDCIGGCVVRTFQVQPLEKGV 236 V+ + + + + + K+W+ I R + Sbjct: 351 VVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWP 410 Query: 237 LHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLL 279 + G L P L+++G+E+G + W++ L+LL Sbjct: 411 ID---GGTSLTPAPPQRDLLLTGHEDGTVRFWDAS-GVCLRLL 449 Score = 34.7 bits (78), Expect = 0.048, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 29/65 (44%), Gaps = 7/65 (10%) Query: 120 IKIWD------TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 173 +K+W+ + + T+ + S+ +L +G DG +R +DA +G C Sbjct: 387 LKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDA-SGVC 445 Query: 174 LKTLT 178 L+ L Sbjct: 446 LRLLY 450 Score = 32.8 bits (73), Expect = 0.22, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 35/103 (33%), Gaps = 6/103 (5%) Query: 163 IRIFD--AETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIG 220 +++++ G +W + G S LL DG V+ WD G Sbjct: 387 LKLWERIIAAGSRQNAHFSTMEWPIDGGT---SLTPAPPQRDLLLTGHEDGTVRFWDASG 443 Query: 221 GCVVRTFQVQPLEKGVLHHSCGMDF-LNPEDGSTPLVISGYEN 262 C+ +++ + + +F ED PL G + Sbjct: 444 VCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFD 486 >5WLC-LH nrPDB Length = 896 Score = 50.9 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 31/75 (41%) Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS 114 R S + GQ +A + I+ L+ + H V+SL+F+ G+ L + Sbjct: 256 TRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQIRLLKWHIDSVLSLSFSHDGSYLLSG 315 Query: 115 SMDESIKIWDTLNGS 129 ++ + +W S Sbjct: 316 GWEKVMSLWQLETNS 330 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 30/187 (16%), Positives = 63/187 (33%), Gaps = 17/187 (9%) Query: 96 TAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILS 155 T V S+ + G L I I + ++ + H ++V+S+ + S +L Sbjct: 256 TRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHIDSVLSLSFSHDGSYLL- 313 Query: 156 SGSYDGLIRIFDAETGHC-----LKTLTYDKDWKRENGVVPISQVKFSENAR-----YLL 205 SG ++ ++ ++ ET L + D G ++ +EN +LL Sbjct: 314 SGGWEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNYYSLILQMTENNSNSDYQFLL 373 Query: 206 VKSLDGVVKI-----WDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGY 260 + + D K+ + Q +S + + S L+ S Sbjct: 374 LNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSITSLNHSKKKQSRKLIKSRR 433 Query: 261 ENGDIYC 267 ++ Sbjct: 434 QDFTTNV 440 Score = 37.4 bits (85), Expect = 0.008, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 31/95 (32%), Gaps = 2/95 (2%) Query: 17 TCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 + I GQ LA+ + I ++ + L+ H L +S DG + + + Sbjct: 260 SSMAIDNMGQQLAVGFASGV-ISIVSLADLQIRLLKWHIDSVLSLSFSHDGSYLLSGGWE 318 Query: 77 FSVEIIHLSYGLLHTFIGHTAPVISLT-FNRKGNL 110 + + L +I +GN Sbjct: 319 KVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNY 353 Score = 34.7 bits (78), Expect = 0.055, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 37/95 (38%), Gaps = 10/95 (10%) Query: 128 GSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN 187 S +++S ++ V S+ + N L+ G G+I I +L + + Sbjct: 246 SSQTQSLSYNTRYVSSMAID-NMGQQLAVGFASGVISI---------VSLADLQIRLLKW 295 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGC 222 + + + FS + YLL + V+ +W Sbjct: 296 HIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNS 330 Score = 33.6 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 29/184 (15%), Positives = 58/184 (31%), Gaps = 31/184 (16%) Query: 99 VISLTFNRKGNLLFT-----------SSMDES--IKIW---DTLNGSLMKT--ISAHSEA 140 + L F + G + T SS D + +K W D +KT I+ H + Sbjct: 495 ITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGIS 554 Query: 141 VVSVDVPM-----NDSSILSSGSYDGLIRIFDA---ETGHCLKTLTYDKDWKRENGVVPI 192 V + N+S + +G ++ + E+ CLK ++ N Sbjct: 555 VPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKIS----LPNFNHFSNS 610 Query: 193 SQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGS 252 + +S++ + D + +I D + + S D + Sbjct: 611 VSLAWSQDGSLIFHGFDDKL-QILDFDTFKKFESLENTKTVSEFTLDSEIQTVKLINDTN 669 Query: 253 TPLV 256 + Sbjct: 670 LIVA 673 >2I3T-A nrPDB Length = 341 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 45/314 (14%), Positives = 95/314 (30%), Gaps = 65/314 (20%) Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYG----LLHTFIGHTAPVISLTFNRKGNL 110 S++ P + S D S+ + L + + P++ F +L Sbjct: 11 KDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDNTDL 70 Query: 111 -LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 ++ ++ I D + + ++ + + + L + S+DGLI + D Sbjct: 71 QIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPR 130 Query: 170 ----------------TGHCLKTLTYDKDWKRENGVVPISQVKF-------SENARY--- 203 T K T D + R + SQV++ +N Sbjct: 131 NYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEES 190 Query: 204 ------------------LLVKSLDGVVKI---------WDCIGGCVVRTFQVQPLEKGV 236 S+DG V + ++ R ++ + + Sbjct: 191 GLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNL 250 Query: 237 LHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCF 296 + ++F + + +G I CWN T+ ++ + V+ I C Sbjct: 251 AYPVNSIEFSPRH----KFLYTAGSDGIISCWNLQTRKKIKNF---AKFNEDSVVKIACS 303 Query: 297 GNIMCSLALNGDCC 310 NI+C + Sbjct: 304 DNILCLATSDDTFK 317 >5K1H-B nrPDB Length = 576 Score = 49.0 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 35/202 (17%), Positives = 67/202 (33%), Gaps = 23/202 (11%) Query: 17 TCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS-- 74 T + SP G +LA I ++ + Q SH + +SP + + T S Sbjct: 169 TYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRF--SHQG-VQLIDFSPCERYLVTFSPL 225 Query: 75 ----DDFS-VEIIHLSYGLLHTFIGHTA----PVISLTFNRKGNLLFTSSMDESIKIWDT 125 DD + I + G + P+ ++ G ++D ++ I++T Sbjct: 226 MDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIF--KWSHDGKFFARMTLD-TLSIYET 282 Query: 126 LNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKR 185 + L+ S + + I D D L L ++ + Sbjct: 283 PSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDK-----DIPARVTLMQLPSRQEIRV 337 Query: 186 ENGVVPISQ-VKFSENARYLLV 206 N + + + +N YL V Sbjct: 338 RNLFNVVDCKLHWQKNGDYLCV 359 Score = 32.4 bits (72), Expect = 0.28, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 41/117 (35%), Gaps = 14/117 (11%) Query: 20 KISPDGQFLAITQGL----NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA-- 73 P+G A+ G ++ Y + + + + + WSP GQ + A Sbjct: 400 AWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFDKQQANTIFWSPQGQFVVLAGL 459 Query: 74 -SDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS-SM-----DESIKIW 123 S + ++ + S + H + ++ G + TS S D + +W Sbjct: 460 RSMNGALAFVDTSDCTVMNIAEHYMA-SDVEWDPTGRYVVTSVSWWSHKVDNAYWLW 515 Score = 32.0 bits (71), Expect = 0.30, Method: Composition-based stats. Identities = 28/184 (15%), Positives = 54/184 (29%), Gaps = 18/184 (9%) Query: 123 WDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKD 182 WD K + + + S I SG D ++ D Sbjct: 110 WDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESG--DRTSIFWNDVK---------DPV 158 Query: 183 WKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCG 242 E + V++S YL + +W ++ F Q ++ ++ S Sbjct: 159 SIEERARWTETYVRWSPKGTYLATFHQ-RGIALWGGEKFKQIQRFSHQGVQ--LIDFSPC 215 Query: 243 MDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCS 302 +L +PL+ + + I W+ T + H P+ G Sbjct: 216 ERYLVT---FSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAH-WPIFKWSHDGKFFAR 271 Query: 303 LALN 306 + L+ Sbjct: 272 MTLD 275 >5WLC-LV nrPDB Length = 707 Score = 48.2 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 33/207 (15%), Positives = 69/207 (33%), Gaps = 14/207 (6%) Query: 56 RPFSELCWSPDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTS 114 + L ++ + + + ++L G L+ F T V ++ N LL Sbjct: 139 KFGRSLVYNKVNCDLYVGASGNELYRLNLEKGRFLNPFKLDTEGVNHVSINEVNGLLAAG 198 Query: 115 SMDESIKIWDTLNGSLMKTISAHSE------AVVSVDVPMNDSSILSSGSYDGLIRIFDA 168 + ++ WD + S + + + V + ND + G+ +G I+D Sbjct: 199 TETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSF-RNDGLTFACGTSNGYSYIYDL 257 Query: 169 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 228 T KD + I + ++ + KIWD + G + + Sbjct: 258 RTSEPSII----KDQGYGFDIKKIIWLDNVGTENKIVTC-DKRIAKIWDRLDGKAYASME 312 Query: 229 VQPLEKGVLHHSCGMDFLNPEDGSTPL 255 ++ + H G + S P+ Sbjct: 313 P-SVDINDIEHVPGTGMFFTANESIPM 338 Score = 32.4 bits (72), Expect = 0.24, Method: Composition-based stats. Identities = 27/177 (15%), Positives = 61/177 (34%), Gaps = 27/177 (15%) Query: 138 SEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 SEA + V + +++G+Y I ++D +L +D+ EN I + Sbjct: 56 SEASNKIKVSRDGQYCMATGTYKPQIHVYDFAN----LSLKFDRHTDAENVDFTILSDDW 111 Query: 198 SENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVI 257 +++ D ++ G + T ++ + ++++ D G Sbjct: 112 TKSVHL----QNDRSIQF--QNKGGLHYTTRIPKFGRSLVYNKVNCDLYVGASG------ 159 Query: 258 SGYENGDIYCWNSDTKSLLQ--LLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 312 ++Y N + L LD +H +SI+ ++ + W Sbjct: 160 -----NELYRLNLEKGRFLNPFKLDTEGVNH----VSINEVNGLLAAGTETNVVEFW 207 >4AV8-A nrPDB Length = 339 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 75/209 (35%), Gaps = 21/209 (10%) Query: 24 DGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD-FSVEII 82 +F+ ++QG I I+ T F +C +G + + + + + Sbjct: 104 SREFIVVSQGDVISIFKFGNPWNKITEDI----KFGGVCEFANGLLVYSNEFNLGQIHVT 159 Query: 83 HLSY------GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDES-IKIWDTLNGSLMKTIS 135 L G H PV + NRKG+++ T S D + I+++ T NG L++ Sbjct: 160 RLQTDAEQVVGKGVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFR 219 Query: 136 --AHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG--HCLKTLTYDKDWKRENGVVP 191 +++ + + S L+ S + +F+ + L + K Sbjct: 220 RGLDRTSIIDMRWSPDGSK-LAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWS 278 Query: 192 ISQ----VKFSENARYLLVKSLDGVVKIW 216 I V N + S G+V +W Sbjct: 279 ICNFKLKVSKGSNDCKIAWISDTGLVIVW 307 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 21/140 (15%), Positives = 49/140 (35%), Gaps = 12/140 (8%) Query: 134 ISAHSEAVVSVDVPMNDSSILSSGSYDGL-IRIFDAETGHCLKTLTYDKDWKRENGVVPI 192 + AH+ V V + ++++ S DG IR+F + G ++ +R I Sbjct: 175 VKAHANPVKMVRLNRKGD-MVATCSQDGTLIRVFQTDNGVLVREF------RRGLDRTSI 227 Query: 193 SQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHS----CGMDFLNP 248 +++S + L V S + +++ + ++ S C Sbjct: 228 IDMRWSPDGSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVS 287 Query: 249 EDGSTPLVISGYENGDIYCW 268 + + + + G + W Sbjct: 288 KGSNDCKIAWISDTGLVIVW 307 Score = 32.4 bits (72), Expect = 0.27, Method: Composition-based stats. Identities = 34/246 (13%), Positives = 71/246 (28%), Gaps = 37/246 (15%) Query: 96 TAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEA-VVSVDVPMNDSSIL 154 + P++ FN+ + L S + K +D N +K I + ++ + + I Sbjct: 14 SNPIVDYEFNQDQSCLIVS----TPKSFDIYNVHPLKRIMSQEMPDAGTIRMLHRTNYIA 69 Query: 155 SSGSYDGLIRIFD---------------------------AETGHCLKTLTYDKDWKREN 187 + L+ I+D G + + W + Sbjct: 70 FVSTKKELLHIWDDVKKQDITRVKLDAAVKDLFLSREFIVVSQGDVISIFKFGNPWNKIT 129 Query: 188 GVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLN 247 + V N LLV S + + V H + Sbjct: 130 EDIKFGGVCEFANG--LLVYSNEFNLGQIHVTRLQTDAEQVVGKGVLVKAHANPVKMVRL 187 Query: 248 PEDGSTPLVISGYENGD-IYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALN 306 G +V + ++G I + +D L++ L S M G+ + ++ Sbjct: 188 NRKGD--MVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGSKLAVVSDK 245 Query: 307 GDCCLW 312 ++ Sbjct: 246 WTLHVF 251 >2VDU-B nrPDB Length = 450 Score = 47.8 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 24/104 (23%), Positives = 38/104 (36%), Gaps = 6/104 (5%) Query: 36 ILIYDINRRTVSQTLVTSHARPFSELCW--SPDGQCIATASD-DFSVEIIHLSYGLLHT- 91 I I I +Q + H +++ DG SD D ++I H + Sbjct: 176 IDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCFIVDK 235 Query: 92 -FIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 134 GH V S+ + LL ++ D+ I WD G + T Sbjct: 236 WLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTF 278 Score = 36.3 bits (82), Expect = 0.016, Method: Composition-based stats. Identities = 31/184 (16%), Positives = 60/184 (32%), Gaps = 25/184 (13%) Query: 139 EAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFS 198 + ++ + ++S +++ D + +FD D +N + + FS Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDV-------------DKTSKNVLKLRKRFCFS 149 Query: 199 ENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEK-------GVLHHSCGMDFLNPEDG 251 + + + D V I D G P EK G + + + DG Sbjct: 150 KRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDG 209 Query: 252 STPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNI-MCSLALNGDCC 310 +I+ + I ++D L+ H V SI C + + S + Sbjct: 210 -HQFIITSDRDEHIKI---SHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIF 265 Query: 311 LWRW 314 W W Sbjct: 266 AWDW 269 Score = 29.7 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 12/88 (13%), Positives = 25/88 (28%), Gaps = 11/88 (12%) Query: 1 MFQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSE 60 M V + +G + + + +I I + + + H S Sbjct: 197 MLTDVHLIKDSDGHQF----------IITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSS 246 Query: 61 LCWSPDGQCIATASDDFSVEIIHLSYGL 88 +C D ++ DD + G Sbjct: 247 ICCGKDYLLLSAGGDDK-IFAWDWKTGK 273 >5WLC-LS nrPDB Length = 594 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 17/108 (15%), Positives = 38/108 (35%), Gaps = 8/108 (7%) Query: 97 APVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHS--EAVVSVDV-----PMN 149 + + SL+F+ LL T D++++I+ + S H + + N Sbjct: 249 SAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQN 308 Query: 150 DSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKF 197 +I ++G + +D + + T + +Q F Sbjct: 309 QQNIFTAGRR-RYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSF 355 Score = 42.4 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 59/171 (34%), Gaps = 15/171 (8%) Query: 56 RPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSS 115 E + +G I D V I + G T T P + ++ ++ L S Sbjct: 430 GEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTT---TCPALQISKIKQNRWLAVGS 486 Query: 116 MDESIKIWDTLNGSLMKT------ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 + ++D N T + + + ++ D IL S ++ DA Sbjct: 487 ESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSP-DGQILCMAS--RAVK--DAL 541 Query: 170 TGHCLKTLTYDKDWKRENG-VVPISQVKFSENARYLLVKSLDGVVKIWDCI 219 L + + +W + ++ V FS + L V + G V++W Sbjct: 542 RLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 20/88 (22%), Positives = 35/88 (39%), Gaps = 7/88 (7%) Query: 5 VTPVGTQNGLKATC--AKISPDGQFLAITQ---GLNILIYDINRRTVSQTLVTSHA--RP 57 TPV + L T + SPDGQ L + + + + +V TS Sbjct: 505 PTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGK 564 Query: 58 FSELCWSPDGQCIATASDDFSVEIIHLS 85 + + +SP G +A ++ V + L+ Sbjct: 565 VTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 Score = 37.0 bits (84), Expect = 0.010, Method: Composition-based stats. Identities = 53/318 (16%), Positives = 98/318 (30%), Gaps = 70/318 (22%) Query: 40 DINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLS---YGLLHTFIGHT 96 DI R + SH+ L + P + T D ++ I H+ L+ + Sbjct: 234 DIVRLKDANASHPSHSA-IQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVG 292 Query: 97 APVISLTF-----NRKGNLLFTSSMDESIKIWDTLNGSLMK----------TISAHSEAV 141 +P+ + TF N+ +FT+ + WD +L + H Sbjct: 293 SPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQ 352 Query: 142 VS--------------------VDVPMNDSSILSSGSYDGL----IRIFDAETGHCLKTL 177 S V + N+ I S GL +I T C+ Sbjct: 353 RSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQ 412 Query: 178 TYDKDWKRE-----NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 232 + R N + + ++N V++ W GG + QV Sbjct: 413 PISRGKFRTILIAVNAYGEVWEFDLNKNGH---------VIRRWKDQGGVGITKIQVG-- 461 Query: 233 EKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN------SDTKSLLQLLDGSLYHH 286 G +C ++ + + G E+G + ++ S T + + LD Sbjct: 462 --GGTTTTCPALQISKIKQN-RWLAVGSESGFVNLYDRNNAMTSSTPTPVAALD--QLTT 516 Query: 287 SSPVMSIHCFGNIMCSLA 304 + + G I+C + Sbjct: 517 TISNLQFSPDGQILCMAS 534 Score = 35.9 bits (81), Expect = 0.024, Method: Composition-based stats. Identities = 23/154 (14%), Positives = 49/154 (31%), Gaps = 6/154 (3%) Query: 161 GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIG 220 +IR + + G + + + IS++K R+L V S G V ++D Sbjct: 442 HVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIK---QNRWLAVGSESGFVNLYD--R 496 Query: 221 GCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLD 280 + + P+ + + DG + S + + + S+ Sbjct: 497 NNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWP 556 Query: 281 GS-LYHHSSPVMSIHCFGNIMCSLALNGDCCLWR 313 S ++ G ++ G LW+ Sbjct: 557 TSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWK 590 Score = 34.7 bits (78), Expect = 0.054, Method: Composition-based stats. Identities = 19/117 (16%), Positives = 43/117 (36%), Gaps = 15/117 (12%) Query: 67 GQCIATASDDFSVEIIHLSYGL-------LHTFIGHTAPVISLTFNRKGNLLFTSSM--- 116 + +A S+ V + + + + T + +L F+ G +L +S Sbjct: 479 NRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVK 538 Query: 117 DESIKIWDTLNGSLMK---TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET 170 D +++ + S+ T V SV + +L+ G+ G +R++ Sbjct: 539 DA-LRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGG-LLAVGNEQGKVRLWKLNH 593 >2EEP-A nrPDB Length = 706 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 37/247 (14%), Positives = 82/247 (33%), Gaps = 26/247 (10%) Query: 63 WSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKI 122 WSP G C+A D S+ H + P+ + T S ++ I Sbjct: 188 WSPKGSCLAFYRMDQSMVK-PTPIVDYHPLEAESKPLY-------YPMAGTPSHHVTVGI 239 Query: 123 WDTLNGSLMKTISAH--SEAVVSVDVPMNDSSILSS----GSYDGLIRIFDAETGHCLKT 176 + G + + + + ++ +++ + + + + +DAETG ++T Sbjct: 240 YHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGRFVRT 299 Query: 177 LTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG--VVKIWDCIGGCVVRTFQVQPLEK 234 L + D + P++ + S N +++ DG + ++D G + + + + Sbjct: 300 LFVETDKHYVEPLHPLTFLPGS-NNQFIWQSRRDGWNHLYLYDTTGRLIRQVTKGEWEVT 358 Query: 235 GVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH 294 L E + YC + L S H + + Sbjct: 359 NFAGFDPKGTRLYFESTEASPL-----ERHFYCIDIKGGKTKDLTPESGMHRT----QLS 409 Query: 295 CFGNIMC 301 G+ + Sbjct: 410 PDGSAII 416 >5OLJ-A nrPDB Length = 723 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 44/289 (15%), Positives = 92/289 (31%), Gaps = 29/289 (10%) Query: 38 IYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFS-VEIIHLSYGLLHTFIGHT 96 +YD + R ++ H +SPDG+ +A D+ ++ + T G Sbjct: 122 VYDYDVRRNLVKPLSEHVGKVMIPTFSPDGRMVAFVRDNNIFIKKFDFDTEVQVTTDGQI 181 Query: 97 APVI--SLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSIL 154 V+ + + + T ++ W N L S AV +PM + + Sbjct: 182 NSVLNGATDWVYEEEFGVT-----NLMSWSADNAFLAFVRSD-ESAVPEYRMPMYEDKLY 235 Query: 155 SSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS----------QVKFSENARYL 204 D + + G T++ + +S ++ F++NA L Sbjct: 236 P---EDYTYKY--PKAGEKNSTVSLHLYNVADRNTKSVSLPIDADGYIPRIAFTDNADEL 290 Query: 205 LVKSLD---GVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYE 261 V +L+ K++ +V +Q + K + G V + Sbjct: 291 AVMTLNRLQNDFKMYYVHPKSLVPKLILQDMNKRYVDSDWIQALKFTAGGGFAYV--SEK 348 Query: 262 NGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCC 310 +G + + D K ++ S + + + G + A Sbjct: 349 DGFAHIYLYDNKGVMHRRITSGNWDVTKLYGVDASGTVFYQSAEESPIR 397 Score = 30.9 bits (68), Expect = 0.68, Method: Composition-based stats. Identities = 17/78 (21%), Positives = 26/78 (33%), Gaps = 17/78 (21%) Query: 20 KISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPF----------------SELCW 63 SPDG+ +A + NI I + T Q + + W Sbjct: 146 TFSPDGRMVAFVRDNNIFIKKFDFDTEVQVTTDGQINSVLNGATDWVYEEEFGVTNLMSW 205 Query: 64 SPDGQCIA-TASDDFSVE 80 S D +A SD+ +V Sbjct: 206 SADNAFLAFVRSDESAVP 223 >4FHN-A nrPDB Length = 394 Score = 41.7 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 44/127 (34%), Gaps = 21/127 (16%) Query: 55 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFI------GHTAPVISL----TF 104 + P L +A D +V +I + T GH V + + Sbjct: 97 SSPVYSL-------FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVY 149 Query: 105 NRKGNL----LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYD 160 + L + + D ++ IW + + S +SV ++ + L G + Sbjct: 150 SADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERN 209 Query: 161 GLIRIFD 167 G IRIFD Sbjct: 210 GNIRIFD 216 Score = 36.7 bits (83), Expect = 0.014, Method: Composition-based stats. Identities = 23/133 (17%), Positives = 41/133 (30%), Gaps = 14/133 (10%) Query: 143 SVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVK-FSENA 201 +V+ S L+ D +R+ + + N V I +S + Sbjct: 94 NVNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADN 153 Query: 202 RY----LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVI 257 R + D + IW R P+ G S G+ + +I Sbjct: 154 RLAEQVIASVGDDCTLIIW--------RLTDEGPILAGYPLSSPGISV-QFRPSNPNQLI 204 Query: 258 SGYENGDIYCWNS 270 G NG+I ++ Sbjct: 205 VGERNGNIRIFDW 217 Score = 32.4 bits (72), Expect = 0.24, Method: Composition-based stats. Identities = 14/138 (10%), Positives = 40/138 (28%), Gaps = 13/138 (9%) Query: 181 KDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVV--RTFQVQPLEKGVLH 238 D P+ + +L D V++ ++ + ++ Sbjct: 89 HDGDGNVNSSPVYSL-------FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVN 141 Query: 239 HSCGMDFLNPED-GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFG 297 D + ++ + ++ S ++ + W + + L G + Sbjct: 142 DIDIADVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPI--LAGYPLSSPGISVQFRPSN 199 Query: 298 -NIMCSLALNGDCCLWRW 314 N + NG+ ++ W Sbjct: 200 PNQLIVGERNGNIRIFDW 217 >4R40-A nrPDB Length = 411 Score = 40.9 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 34/221 (15%), Positives = 72/221 (32%), Gaps = 19/221 (8%) Query: 56 RPFSELCWSPDGQCIATA---SDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLF 112 P WSPDG IA S ++ I L+ G + + F+ G L Sbjct: 181 EPLMSPAWSPDGSKIAYVTFESGKSALVIQTLANGAIRQVASFPRHNGAPAFSPDGTKLA 240 Query: 113 ---TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 + S ++ + D +G + + S + ++ + G +++ Sbjct: 241 FALSKSGSLNLYVMDLASGQISQVTDGRSNN-TEPSWFPDSQNLAYTSDQGGRPQVYKVN 299 Query: 170 -TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGV---VKIWDCIGGCVVR 225 G + +T++ + V S + ++L++ S +G + D G V Sbjct: 300 INGGVPQRITWEGSQNQNADV--------SPDGKFLVLVSSNGGAQHIAKQDLETGAVQV 351 Query: 226 TFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIY 266 E + + M + G ++ +G Sbjct: 352 LTDTLLDETPSIAPNGTMVIYSSTQGLGSVLQLVSTDGRFK 392 Score = 34.7 bits (78), Expect = 0.052, Method: Composition-based stats. Identities = 27/102 (26%), Positives = 42/102 (41%), Gaps = 13/102 (12%) Query: 20 KISPDGQFLAI----TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 75 SPDG LA + LN+ + D+ +SQ VT +E W PD Q +A SD Sbjct: 231 AFSPDGTKLAFALSKSGSLNLYVMDLASGQISQ--VTDGRSNNTEPSWFPDSQNLAYTSD 288 Query: 76 DF---SVEIIHLSYGLLH--TFIGHTAPVISLTFNRKGNLLF 112 V ++++ G+ T+ G + + G L Sbjct: 289 QGGRPQVYKVNINGGVPQRITWEGSQNQNADV--SPDGKFLV 328 >3WJ9-A nrPDB Length = 412 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 28/79 (35%), Gaps = 9/79 (11%) Query: 56 RPFSELCWSPDGQCIATASDDF---SVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLF 112 P + L +SP+ + I A S++I + + A F+ L Sbjct: 310 APRNTLIFSPNSRYILLAGFGNLQGSIDIFDAANNMKKITTVEAANCTYCEFSPDSQFLL 369 Query: 113 TSSM------DESIKIWDT 125 T+ D SIKIW Sbjct: 370 TAVTSPRLRVDNSIKIWHI 388 Score = 35.1 bits (79), Expect = 0.035, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 42/142 (29%), Gaps = 36/142 (25%) Query: 96 TAPVISLTFNRKGNLLF---------TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDV 146 P+ + +N T+ D + + + T+ Sbjct: 268 EGPIHDVCWNADSKEFGIVYGYMPAKTAIFDNRANVVSIIPPAPRNTLI----------F 317 Query: 147 PMNDSSILSSG--SYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYL 204 N IL +G + G I IFDA + + +FS ++++L Sbjct: 318 SPNSRYILLAGFGNLQGSIDIFDAAN---------NMKKITTVEAANCTYCEFSPDSQFL 368 Query: 205 LVKSL------DGVVKIWDCIG 220 L D +KIW G Sbjct: 369 LTAVTSPRLRVDNSIKIWHITG 390 Score = 29.0 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 40/130 (30%), Gaps = 21/130 (16%) Query: 126 LNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKR 185 N + A SE + N + + +I D E+G L L Sbjct: 22 ENYASPPKFEAISEPARNACYSPNGKLFAYATATQVVIN--DTESGAKLTQLPA------ 73 Query: 186 ENGVVPISQVKFSENARYLLV---------KSLDGVVKIWDCIGGCVVRTFQVQPLEKGV 236 ++ FS +YL + +K+W+ G +V +F + Sbjct: 74 ----ANTYELGFSPLGKYLSTWERPGKEADGTPKQNMKVWNTETGQLVFSFVQRNQTGWN 129 Query: 237 LHHSCGMDFL 246 L ++C Sbjct: 130 LQYTCDESLA 139 >4YHC-A nrPDB Length = 468 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 38/91 (41%), Gaps = 4/91 (4%) Query: 53 SHARPFSELCWSPDGQCIATASDDFSVEIIHLS---YGLLHTFIGHTAPVISLTFNRKGN 109 H ++ S + + A+ D S+ + L L+ + + ++ + +GN Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 110 LLFTSSMDESIKIWDTLNGSLMKTISAHSEA 140 + S D ++ I + + SLM S HS+ Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHSKP 117 Score = 33.6 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 16/110 (14%), Positives = 37/110 (33%), Gaps = 9/110 (8%) Query: 167 DAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRT 226 + T L + + + + I ++ SEN + LD + +WD C Sbjct: 8 ELSTDTTLHEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLV 67 Query: 227 FQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLL 276 + + + + G+ + S ++ N ++ SL+ Sbjct: 68 LSKEQMPRTL------KAIALDPQGNYVSLFSKD---TLFILNVESPSLM 108 Score = 31.3 bits (69), Expect = 0.64, Method: Composition-based stats. Identities = 17/130 (13%), Positives = 41/130 (31%), Gaps = 8/130 (6%) Query: 61 LCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESI 120 + WS + S D ++ + + H ++ + + + +D S+ Sbjct: 1 MGWSDHDEL----STDTTLHEEKFRIEPVP--VHHQLDILKIAVSENYKTFASVGLDRSL 54 Query: 121 KIWDTLNGSLMKTISAHSEA-VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY 179 +WD +S + + +S S D + I + E+ + +Y Sbjct: 55 VVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVESPSLMLQHSY 113 Query: 180 DKDWKRENGV 189 + V Sbjct: 114 HSKPNSKLNV 123 Score = 28.2 bits (61), Expect = 5.4, Method: Composition-based stats. Identities = 5/55 (9%), Positives = 17/55 (30%) Query: 252 STPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALN 306 + S + + W+ +L + +++ GN + + + Sbjct: 41 NYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKD 95 >5BPW-A nrPDB Length = 843 Score = 36.7 bits (83), Expect = 0.015, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 42/108 (38%), Gaps = 8/108 (7%) Query: 56 RPFSELCWSPDGQCIATASDDFSVEIIHL-SYGLLHTFIGHT---APVISLTFNRKGNLL 111 + L WSP IA A+ V + L S+ + +F + V L + G LL Sbjct: 21 QEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLL 80 Query: 112 FTSSMD-ESIKIWDTLNGSLMKTISAHSEAVVSVDVP--MNDSSILSS 156 + D + I + D + + S V + +SS+L+S Sbjct: 81 AFALADTKKIVLCDVEKPESLHSFSV-EAPVSCMHWMEVTVESSVLTS 127 Score = 35.5 bits (80), Expect = 0.029, Method: Composition-based stats. Identities = 14/57 (24%), Positives = 18/57 (31%) Query: 7 PVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCW 63 P G + TC PDG+ LA I + S P S + W Sbjct: 59 PPNENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHW 115 Score = 34.7 bits (78), Expect = 0.052, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 21/51 (41%), Gaps = 1/51 (1%) Query: 55 ARPFSELCWSPDGQCIATA-SDDFSVEIIHLSYGLLHTFIGHTAPVISLTF 104 + + L W PDG+ +A A +D + + + APV + + Sbjct: 65 GKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHW 115 >1C5K-A nrPDB Length = 439 Score = 35.9 bits (81), Expect = 0.022, Method: Composition-based stats. Identities = 35/221 (15%), Positives = 75/221 (33%), Gaps = 19/221 (8%) Query: 56 RPFSELCWSPDGQCIATA---SDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKG-NLL 111 +P WSPDG +A S ++ I L+ G + + F+ G L Sbjct: 201 QPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNGAPAFSPDGSKLA 260 Query: 112 FTSSMDESIKIW--DTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 169 F S S+ ++ D +G + + S + ++ + G +++ Sbjct: 261 FALSKTGSLNLYVMDLASGQIRQVTDGRSNN-TEPTWFPDSQNLAFTSDQAGRPQVYKVN 319 Query: 170 -TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGV---VKIWDCIGGCVVR 225 G + +T++ ++ V S + +++++ S +G + D G V Sbjct: 320 INGGAPQRITWEGSQNQDADV--------SSDGKFMVMVSSNGGQQHIAKQDLATGGVQV 371 Query: 226 TFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIY 266 E L + M + G ++ +G Sbjct: 372 LSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFK 412 >4NOX-A nrPDB Length = 746 Score = 35.9 bits (81), Expect = 0.024, Method: Composition-based stats. Identities = 22/134 (16%), Positives = 46/134 (34%), Gaps = 20/134 (14%) Query: 8 VGTQNGLKATCAKISPDGQFLAI-----TQGLNILIYDIN-----------RRTVSQTLV 51 + T SP G+F+ I TQ ++ +D++ Q + Sbjct: 516 LRTLEKKNHNAIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENEKDLAACLQLMG 575 Query: 52 TSHARPFSELCWSPDGQCIAT--ASDDFSVEIIHLSYGLLHTFIG--HTAPVISLTFNRK 107 T +++ W P G+ +AT ++ ++E + Y + H + + Sbjct: 576 TGDHYGITDVEWDPSGRYVATWASAWKHTMENGYHLYDFKGELLREEHIEKFKQWQWRPR 635 Query: 108 GNLLFTSSMDESIK 121 L T + I+ Sbjct: 636 PPTLLTKEEQKQIR 649 Score = 34.3 bits (77), Expect = 0.068, Method: Composition-based stats. Identities = 15/120 (12%), Positives = 37/120 (30%), Gaps = 28/120 (23%) Query: 17 TCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 T + SP G +L + ++ + + + + +SP + + T S+ Sbjct: 202 TFVQWSPLGTYLTSVHAQGVQLWGGASWSRLRRFPHP---FVNLVAFSPGEKYLVTWSN- 257 Query: 77 FSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMD-ESIKIWDTLNGSLMKTIS 135 + G+ + T D ++ IWD +++ + Sbjct: 258 -----------------------RPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRSFA 294 >5CWW-B nrPDB Length = 595 Score = 35.9 bits (81), Expect = 0.025, Method: Composition-based stats. Identities = 15/96 (15%), Positives = 31/96 (32%), Gaps = 20/96 (20%) Query: 55 ARPFSELCWSPDGQCIATA----------SDDFSVEIIHLSYGLLHTFI----GH---TA 97 A +L SP+ +A D + I + + H + Sbjct: 114 ADDIRQLVMSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSRS 173 Query: 98 PVISLTFNR---KGNLLFTSSMDESIKIWDTLNGSL 130 V+S ++ G+ L T + D +++W+ Sbjct: 174 AVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADR 209 Score = 32.8 bits (73), Expect = 0.22, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 31/97 (31%), Gaps = 19/97 (19%) Query: 22 SPDGQFLAITQGLNILI----------------YDINRRTVSQTLVTSHARPFSELCWSP 65 SP+ FLA+ + I + T+ T + W P Sbjct: 123 SPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSRSAVVSAVWHP 182 Query: 66 ---DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPV 99 +G + T ++D V + LS TF T + Sbjct: 183 LGVNGHALVTVTEDAIVRVWELSTADRWTFDAPTLAI 219 >6IGB-A nrPDB Length = 364 Score = 35.9 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 48/322 (14%), Positives = 97/322 (30%), Gaps = 48/322 (14%) Query: 29 AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF----------- 77 ++G+ + +D +V L +H S L ++PD + + +++ Sbjct: 14 GSSEGIQVYRFDGADGSVKGPLRVAHTSNPSYLTFAPDQRTLFVVNENGRGGKGDTVGRA 73 Query: 78 SVEIIHLSYGLLHTFIGH----TAPVISLTFNRKGNLLFTSSM---------------DE 118 + G L P S + + G LF ++ D Sbjct: 74 TSYRFDPISGRLQQISQVQTLADHPTYS-SLSHDGRYLFVANYSVQPEGSVAVLPVRADG 132 Query: 119 SIK-IWDTLNGSL----MKTISAHSEAVVSVDVPMNDSSILSS--GSYDGLIRIFDAETG 171 S+ + + + +S H +VVS D L + D + ++ Sbjct: 133 SLAPVVQVESHQASKVHPRQVSGHVHSVVS----SPDGQYLFAPDLGADK-VFVYRYAPE 187 Query: 172 HCLKTL-TYDKDWKRENGVVPISQVKFSENARY-LLVKSLDGVVKIWDCIGGCVVRTFQV 229 + L D + + FS + R+ L L G V ++ G +R Q Sbjct: 188 QAERPLQAADPAFVPTPPGSGPRHLIFSADGRFAYLTLELSGQVMVFAHEGNGRLRQLQT 247 Query: 230 QPL-EKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW--NSDTKSLLQLLDGSLYHH 286 L G DG V++ ++ + + + + L + S+ Sbjct: 248 HDLAPAGFQGKVGAGALHLSADGRFLGVLNRGDDNQLVTFAVDPASGQLRFVERRSVEGT 307 Query: 287 SSPVMSIHCFGNIMCSLALNGD 308 + G + N D Sbjct: 308 EPREFAFSPGGRFVLVANQNSD 329 >5GRS-A nrPDB Length = 396 Score = 35.5 bits (80), Expect = 0.027, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 36/91 (39%), Gaps = 4/91 (4%) Query: 53 SHARPFSELCWSPDGQCIATASDDFSVEIIHLS---YGLLHTFIGHTAPVISLTFNRKGN 109 H ++ S + + A+ D + + L L+ + + ++ + +GN Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 110 LLFTSSMDESIKIWDTLNGSLMKTISAHSEA 140 + S D ++ I + + SLM S H + Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHCKP 117 Score = 28.2 bits (61), Expect = 4.5, Method: Composition-based stats. Identities = 16/130 (12%), Positives = 40/130 (30%), Gaps = 8/130 (6%) Query: 61 LCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESI 120 + WS + S D ++ + + H ++ + + + +D + Sbjct: 1 MGWSDHDEL----STDTTLHEEKFRIEPVP--VHHQLDILKIAVSENYKTFASVGLDRCL 54 Query: 121 KIWDTLNGSLMKTISAHSEA-VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTY 179 +WD +S + + +S S D + I + E+ + +Y Sbjct: 55 VVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVESPSLMLQHSY 113 Query: 180 DKDWKRENGV 189 + V Sbjct: 114 HCKPNSKLNV 123 Score = 27.4 bits (59), Expect = 8.8, Method: Composition-based stats. Identities = 5/55 (9%), Positives = 17/55 (30%) Query: 252 STPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALN 306 + S + + W+ +L + +++ GN + + + Sbjct: 41 NYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKD 95 >5BPT-A nrPDB Length = 741 Score = 35.5 bits (80), Expect = 0.027, Method: Composition-based stats. Identities = 15/102 (14%), Positives = 27/102 (26%), Gaps = 16/102 (15%) Query: 56 RPFSELCWSPDGQCIATASDDFSV---------EIIHLSYGLLHTFIGHTAPVISLTFNR 106 L WSP IA + V + L V L + Sbjct: 14 HEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTG-----KEVTCLAWRP 68 Query: 107 KGNLLFTSSMD-ESIKIWDTLNGSLMKTISAHSEAVVSVDVP 147 G +L D + + + D + + S + + + Sbjct: 69 DGKILAFGLADTKKVILCDVEKPESLHSFSLET-PISCMQWM 109 Score = 33.6 bits (75), Expect = 0.10, Method: Composition-based stats. Identities = 13/59 (22%), Positives = 22/59 (37%), Gaps = 4/59 (6%) Query: 7 PVGTQNGLKATCAKISPDGQFLAITQGLN--ILIYDINRRTVSQTLVTSHARPFSELCW 63 P G + TC PDG+ LA +++ D+ + + P S + W Sbjct: 52 PPNENTGKEVTCLAWRPDGKILAFGLADTKKVILCDVEKPESLHSFSL--ETPISCMQW 108 Score = 33.6 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 14/90 (15%), Positives = 30/90 (33%), Gaps = 4/90 (4%) Query: 19 AKISPDGQFLAI---TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA-S 74 SP +A+ + + +R S + + + L W PDG+ +A + Sbjct: 19 LAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKILAFGLA 78 Query: 75 DDFSVEIIHLSYGLLHTFIGHTAPVISLTF 104 D V + + P+ + + Sbjct: 79 DTKKVILCDVEKPESLHSFSLETPISCMQW 108 >3FGB-A nrPDB Length = 361 Score = 35.5 bits (80), Expect = 0.032, Method: Composition-based stats. Identities = 32/193 (16%), Positives = 67/193 (34%), Gaps = 42/193 (21%) Query: 18 CAKISPDGQFL------------------AITQGLNILIYDINRRTVSQTLVTSHARPFS 59 C +I+PDG++L A ++ + + + V + + P Sbjct: 151 CVRITPDGKYLFADDLGTDQIHKFIVNPNAKADNEDVF---LKEGSPASYKVEAGSGP-R 206 Query: 60 ELCWSPDGQCI-ATASDDFSVEIIHLSYGLLHTFIGHTAPVI------SLTFNRKGNLLF 112 L ++P+G +V + G L A + + + G L+ Sbjct: 207 HLTFAPNGSYAYLINELSGTVIAFEYNDGELKEIQTIAADTVGAKGSGDIHISPDGKFLY 266 Query: 113 TSSM---DESIKIWDT--LNGSLMKT---ISA-HSEAVVSVDVPMNDSSILSSGSYDGLI 163 S+ D + I+ NG L K ++ H + + N +L + +I Sbjct: 267 ASNRLKADG-LAIFSIHPENGMLTKVGYQLTGIHP---RNFIITPNGKYLLVACRDSNVI 322 Query: 164 RIFDAETGHCLKT 176 ++++ +T L T Sbjct: 323 QVYERDTDTGLLT 335 >6FYY-p nrPDB Length = 763 Score = 34.3 bits (77), Expect = 0.070, Method: Composition-based stats. Identities = 31/168 (18%), Positives = 58/168 (34%), Gaps = 34/168 (20%) Query: 102 LTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS--- 158 + F+ KG LF+ + + W N ++ H + V + V N+ +++ + Sbjct: 236 VRFSPKGTYLFS-YHQQGVTAWGGPNFDRLRRFY-HPD-VRNSSVSPNEKYLVTFSTEPI 292 Query: 159 ---YDG------------LIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARY 203 D + I+D +G + T K + + V++S N +Y Sbjct: 293 IVEEDNEFSPFTKKNEGHQLCIWDIASGLLMATFPVIKSPYLKWPL-----VRWSYNDKY 347 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG 251 D ++ + D PLE L S DF +G Sbjct: 348 CARMVGDSLI-VHDATKN-------FMPLEAKALKPSGIRDFSFAPEG 387 Score = 32.8 bits (73), Expect = 0.18, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 38/130 (29%), Gaps = 9/130 (6%) Query: 159 YDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ-VKFSENARYLLVKSLDGVVKIWD 217 D + D +T ++ ++D E+ + V+FS YL G V W Sbjct: 199 RDQFVLQDDVKTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWG 257 Query: 218 CIGGCVVRTFQVQPLEKGVLHHS-------CGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 +R F + + + + ED E + W+ Sbjct: 258 GPNFDRLRRFYHPDVRNSSVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDI 317 Query: 271 DTKSLLQLLD 280 + L+ Sbjct: 318 ASGLLMATFP 327 >2XE4-A nrPDB Length = 751 Score = 34.0 bits (76), Expect = 0.080, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 59/177 (33%), Gaps = 18/177 (10%) Query: 102 LTFNRKGNLLFTSSMDESI---KIWDTLNGSLMKT----ISAHSEAVVSVDVPMNDSSIL 154 + + LF + DE++ K+W + G L H+ + D++ L Sbjct: 226 IVWGPDHTSLFYVTKDETLRENKVWRHVMGKLQSEDVCLYEEHNPLFSAFMYKAADTNTL 285 Query: 155 SSGSYD---GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDG 211 GS + + D G+ TL + ++ V+ + +++ + G Sbjct: 286 CIGSQSPETAEVHLLDLRKGNAHNTLEIVRPREKGVR----YDVQMHGTSHLVILTNEGG 341 Query: 212 VVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW 268 V + Q ++ HS + + S LV++G G W Sbjct: 342 AVN----HKLLIAPRGQPSDWSHVLVDHSEDVFMESIAVRSNYLVVAGRRAGLTRIW 394 Score = 33.2 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 23/69 (33%) Query: 132 KTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 191 + HSE V + + + ++ +G GL RI+ + P Sbjct: 360 HVLVDHSEDVFMESIAVRSNYLVVAGRRAGLTRIWTMMADSQDGVFKAGTGLREVVMEEP 419 Query: 192 ISQVKFSEN 200 I V E+ Sbjct: 420 IFTVHLVES 428 >5WLC-LL nrPDB Length = 643 Score = 33.2 bits (74), Expect = 0.14, Method: Composition-based stats. Identities = 26/127 (20%), Positives = 50/127 (39%), Gaps = 14/127 (11%) Query: 39 YDINRRTVSQTLVTSHARPFSELCWSPDGQC---IATASDDFSVEIIHLSYGLLH-TFIG 94 +D+ + + Q ++ ++L P G + AS S+ +I + + TF G Sbjct: 129 FDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVAS--HSISLIDIEEKKVVMTFPG 186 Query: 95 HTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA--------HSEAVVSVDV 146 H +PV +L + + D + ++D +G + A HS S+ V Sbjct: 187 HVSPVSTLQVITNEFFISGAEGDRFLNVYDIHSGMTKCVLVAESDIKELSHSGQADSIAV 246 Query: 147 PMNDSSI 153 D S+ Sbjct: 247 TTEDGSL 253 Score = 29.7 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 33/214 (15%), Positives = 70/214 (32%), Gaps = 30/214 (14%) Query: 58 FSELCW----SPDGQCIATASDDFSVEIIHLSYGLL--HTFIGHTAPVISLTFNRKGNLL 111 + L W S D I ++ + + + + G++ + + GN L Sbjct: 60 VTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFTTGNSYEIKDIDL--MGNQL 117 Query: 112 FTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS-------YDGLIR 164 + ++ +D L L++ + + V +N +I+ +G I Sbjct: 118 WCIDSSDAFYQFDLLQFKLLQHF-----RINNC-VQLNKLTIVPAGDSVAQLLVASHSIS 171 Query: 165 IFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVV 224 + D E + T V P+S ++ N ++ D + ++D G Sbjct: 172 LIDIEEKKVVMTFPGH--------VSPVSTLQVITNEFFISGAEGDRFLNVYDIHSGMTK 223 Query: 225 RTFQVQPLEKGVLHHSCGMDFL-NPEDGSTPLVI 257 + K + H EDGS + + Sbjct: 224 CVLVAESDIKELSHSGQADSIAVTTEDGSLEIFV 257 >2ZZK-A nrPDB Length = 695 Score = 32.4 bits (72), Expect = 0.23, Method: Composition-based stats. Identities = 17/65 (26%), Positives = 22/65 (33%), Gaps = 7/65 (10%) Query: 17 TCAKISPDGQFLAITQ-------GLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQC 69 T IS + Q L I + I+D+ R S SH R C PDG Sbjct: 444 TFTTISRNNQLLLIGGRKAPHQGLSDNWIFDMKTREWSMIKSLSHTRFRHSACSLPDGNV 503 Query: 70 IATAS 74 + Sbjct: 504 LILGG 508 >4U1F-A nrPDB Length = 497 Score = 32.4 bits (72), Expect = 0.28, Method: Composition-based stats. Identities = 31/168 (18%), Positives = 58/168 (34%), Gaps = 34/168 (20%) Query: 102 LTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS--- 158 + F+ KG LF+ + + W N ++ H + V + V N+ +++ + Sbjct: 68 VRFSPKGTYLFS-YHQQGVTAWGGPNFDRLRRFY-HPD-VRNSSVSPNEKYLVTFSTEPI 124 Query: 159 ---YDG------------LIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARY 203 D + I+D +G + T K + + V++S N +Y Sbjct: 125 IVEEDNEFSPFTKKNEGHQLCIWDIASGLLMATFPVIKSPYLKWPL-----VRWSYNDKY 179 Query: 204 LLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDG 251 D ++ + D PLE L S DF +G Sbjct: 180 CARMVGDSLI-VHDATKN-------FMPLEAKALKPSGIRDFSFAPEG 219 Score = 32.0 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 38/130 (29%), Gaps = 9/130 (6%) Query: 159 YDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ-VKFSENARYLLVKSLDGVVKIWD 217 D + D +T ++ ++D E+ + V+FS YL G V W Sbjct: 31 RDQFVLQDDVKTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWG 89 Query: 218 CIGGCVVRTFQVQPLEKGVLHHS-------CGMDFLNPEDGSTPLVISGYENGDIYCWNS 270 +R F + + + + ED E + W+ Sbjct: 90 GPNFDRLRRFYHPDVRNSSVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDI 149 Query: 271 DTKSLLQLLD 280 + L+ Sbjct: 150 ASGLLMATFP 159 >6IGR-A nrPDB Length = 656 Score = 32.0 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 23/144 (15%), Positives = 45/144 (31%), Gaps = 13/144 (9%) Query: 20 KISPDGQFLA---ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDD 76 + SPDGQ LA + + + + VT S WSPDG+ IA + Sbjct: 85 RWSPDGQNLAFVRSAGEVKAALMLLPLKGGEARRVTHFKNGVSGPQWSPDGRFIAFTTTA 144 Query: 77 FSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA 136 + + G + + ++ ++D ++ A Sbjct: 145 DTEDKRD-ERGEARVLTRPVYRANGADWLPERP--------AALWLYDVEADK-LREWYA 194 Query: 137 HSEAVVSVDVPMNDSSILSSGSYD 160 + ++ + +L S D Sbjct: 195 PEIGIGALSWWPDSRGVLIVQSED 218 >3MWP-A nrPDB Length = 577 Score = 31.7 bits (70), Expect = 0.39, Method: Composition-based stats. Identities = 7/46 (15%), Positives = 17/46 (36%), Gaps = 1/46 (2%) Query: 108 GNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 GN + D +++WD N L+ + +++ + Sbjct: 157 GNQGARAGRDGVVRVWDVKNAELLNNQFG-TMPSLTLACLTKQGQV 201 >2ECF-A nrPDB Length = 741 Score = 31.3 bits (69), Expect = 0.58, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 29/76 (38%), Gaps = 2/76 (2%) Query: 20 KISPDGQFLAITQGLNILIYDINRRTVSQTLVTSH-ARPFSELCWSPDGQCIATASDDFS 78 + SPD Q L G + +YD+ + + +H ++ SP G + + Sbjct: 115 QWSPDAQRLLFPLGGELYLYDLKQEGKAAVRQLTHGEGFATDAKLSPKGGF-VSFIRGRN 173 Query: 79 VEIIHLSYGLLHTFIG 94 + +I L+ G Sbjct: 174 LWVIDLASGRQMQLTA 189 >3R3L-A nrPDB Length = 582 Score = 30.9 bits (68), Expect = 0.77, Method: Composition-based stats. Identities = 5/40 (12%), Positives = 15/40 (37%), Gaps = 1/40 (2%) Query: 114 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 153 + D +++WD N L+ + +++ + Sbjct: 155 AGRDGVVRVWDVKNAELLNNQFG-TMPSLTLACLTKQGQV 193 >5TXC-A nrPDB Length = 705 Score = 30.9 bits (68), Expect = 0.85, Method: Composition-based stats. Identities = 14/89 (15%), Positives = 27/89 (30%), Gaps = 8/89 (8%) Query: 20 KISPDGQFLAITQGL--NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 + SP G LA + + ++ + + + V A ++ W D I + F Sbjct: 133 RWSPSGTHLAYLRQDQGRVRVWRASVKGEGASPVIEDAYDIEDVQWLDDNTLIYSGRPGF 192 Query: 78 SVEIIHLSYGLLHTFIGHTAPVISLTFNR 106 + G V F+ Sbjct: 193 ------VEAEAEIEREGRRGWVYDERFHP 215 >6BN7-A nrPDB Length = 864 Score = 30.1 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 31/82 (37%), Gaps = 7/82 (8%) Query: 77 FSVEIIHLSYGLLHTFIGHTAPVISLTFN---RKGNLLFTSSMDESIKIWDTLNGSLMKT 133 + + S G L T V ++ G LL + + ++++++ ++T Sbjct: 570 GRIVVFQYSDGKLQTVA--EKEVKGAVYSMVEFNGKLLASINS--TVRLYEWTTEKELRT 625 Query: 134 ISAHSEAVVSVDVPMNDSSILS 155 H ++++ + IL Sbjct: 626 ECNHYNNIMALYLKTKGDFILV 647 >4LA1-A nrPDB Length = 602 Score = 29.7 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 23/71 (32%), Gaps = 11/71 (15%) Query: 5 VTPVGTQNGLKATCAKI--------SPDGQFLAITQGLNILIYDINRRTVSQ---TLVTS 53 TP+GT GL TC + G + + +++ +S T+V Sbjct: 147 PTPMGTTWGLGGTCVNVGCIPKKLMHQAGLLSHSLEDAQHFGWSLDKSEISHDWSTMVEG 206 Query: 54 HARPFSELCWS 64 L W Sbjct: 207 VQSHIGSLNWG 217 >4DGS-A nrPDB Length = 340 Score = 29.7 bits (65), Expect = 1.6, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 29/77 (37%), Gaps = 8/77 (10%) Query: 43 RRTVSQTLVTSHA---RPFSELCWSPDGQCIATASDDF--SVEIIHLSYGLLHTFIGHTA 97 R + L H+ + L G+ +A+ ++ F SV + S +I H + Sbjct: 156 RWAAGEQLPLGHSPKGKRIGVLGLGQIGRALASRAEAFGMSVRYWNRSTLSGVDWIAHQS 215 Query: 98 PVISLTFNRKGNLLFTS 114 PV R ++L Sbjct: 216 PV---DLARDSDVLAVC 229 >2X8H-A nrPDB Length = 598 Score = 29.7 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 23/71 (32%), Gaps = 11/71 (15%) Query: 5 VTPVGTQNGLKATCAKI--------SPDGQFLAITQGLNILIYDINRRTVSQ---TLVTS 53 TP+GT GL TC + G + + ++R +S T+V Sbjct: 141 PTPIGTTWGLGGTCVNVGCIPKKLMHQAGLLSHALEDAEHFGWSLDRSKISHNWSTMVEG 200 Query: 54 HARPFSELCWS 64 L W Sbjct: 201 VQSHIGSLNWG 211 >3CLR-C nrPDB Length = 264 Score = 29.7 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 31/94 (32%) Query: 166 FDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVR 225 +D + + D E VV + + E+ R L K D V++WD Sbjct: 38 WDDFSLEEAMKIKESSDTDVEVVVVSVGPDRVDESLRKCLAKGADRAVRVWDDAAEGSDA 97 Query: 226 TFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 259 + L + + + M F + +G Sbjct: 98 IVVGRILTEVIKKEAPDMVFAGVQSSDQAYASTG 131 >4BP8-A nrPDB Length = 715 Score = 29.3 bits (64), Expect = 2.2, Method: Composition-based stats. Identities = 27/164 (16%), Positives = 57/164 (34%), Gaps = 27/164 (16%) Query: 29 AITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP--DGQCIATAS---DDFSVEIIH 83 A + + + I + + + P + DG+ + S + ++ Sbjct: 210 ASKRDNKVWRHIIGQPQSEDVCLYTDDDPLFSVGVGRSGDGKTLIICSMSSETSESHLLD 269 Query: 84 LSYGLLHTFIGHTAP----V-ISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT----- 133 L G+ H + P V ++ + L+ ++ D+ + NG ++ T Sbjct: 270 LRKGVKHNTLEMVRPREKGVRYTVEMHGTDTLIVLTNKDKCV------NGKVVLTKRSAP 323 Query: 134 ------ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETG 171 + H + V DV + + SG DGL R++ G Sbjct: 324 TDWGTVLIPHDDKVTIDDVAVFAKFAVLSGRRDGLTRVWTVRLG 367 >3AZQ-A nrPDB Length = 662 Score = 29.0 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 15/115 (13%), Positives = 33/115 (28%), Gaps = 23/115 (20%) Query: 2 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSEL 61 + P G + A+++ DG+F ++TL+ ++ Sbjct: 205 LAWDHPRMPWEGTELKTARVTEDGRF-----------------ADTRTLLGGPEEAIAQA 247 Query: 62 CWSPDGQCIATASDDFS----VEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLF 112 W+PDG I + D + + + + G + Sbjct: 248 EWAPDGSLIV--ATDRTGWWNLHRVDPATGAATQLCRREEEFAGPLWTPGMRWFA 300 >5YP1-A nrPDB Length = 745 Score = 28.6 bits (62), Expect = 3.3, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 29/77 (37%), Gaps = 4/77 (5%) Query: 20 KISPDGQFLAITQGLNILIYDINR--RTVSQTLVTSHARPFSELCWSPDGQCIATASDDF 77 + SPDG+ L G + YD+ + R + L ++ SP G + D Sbjct: 117 QWSPDGKALLFPLGGELYFYDLTKSGRDAVRKLTNG-GGFATDPKISPKGGF-VSFIRDR 174 Query: 78 SVEIIHLSYGLLHTFIG 94 ++ I L+ G Sbjct: 175 NLWAIDLASGKEVQLTR 191 >5SUM-A nrPDB Length = 468 Score = 28.6 bits (62), Expect = 4.1, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 15/31 (48%) Query: 142 VSVDVPMNDSSILSSGSYDGLIRIFDAETGH 172 S + ++D L G D +RIFD +T Sbjct: 368 SSTYIHVHDGKYLLQGGLDRYVRIFDIKTNK 398 Score = 28.2 bits (61), Expect = 4.8, Method: Composition-based stats. Identities = 5/26 (19%), Positives = 11/26 (42%) Query: 106 RKGNLLFTSSMDESIKIWDTLNGSLM 131 G L +D ++I+D ++ Sbjct: 375 HDGKYLLQGGLDRYVRIFDIKTNKML 400 Score = 28.2 bits (61), Expect = 5.4, Method: Composition-based stats. Identities = 8/25 (32%), Positives = 14/25 (56%) Query: 200 NARYLLVKSLDGVVKIWDCIGGCVV 224 + +YLL LD V+I+D ++ Sbjct: 376 DGKYLLQGGLDRYVRIFDIKTNKML 400 >4H0U-A nrPDB Length = 266 Score = 28.2 bits (61), Expect = 4.9, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 22/78 (28%), Gaps = 9/78 (11%) Query: 39 YDINRRTVSQTLVTSHARPF-SELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTA 97 +D+N T H EL W G D ++ I + G Sbjct: 39 FDLNEGFPLLTTKKVHFHSVVGELLWFLQGDSNVKWLQDNNIRIWN----EWADEDGELG 94 Query: 98 PVISLTFN----RKGNLL 111 PV + + G + Sbjct: 95 PVYGVQWRSWPTPDGRHI 112 >1YJS-A nrPDB Length = 419 Score = 28.2 bits (61), Expect = 5.4, Method: Composition-based stats. Identities = 10/63 (15%), Positives = 20/63 (31%), Gaps = 1/63 (1%) Query: 145 DVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYL 204 N+ L SG D + + D L T +K V + + + + ++ Sbjct: 294 SALQNEGFTLVSGGTDNHLLLVDLR-PQQLTGKTAEKVLDEVGITVNKNTIPYDPESPFV 352 Query: 205 LVK 207 Sbjct: 353 TSG 355 >4KQP-A nrPDB Length = 232 Score = 27.8 bits (60), Expect = 5.9, Method: Composition-based stats. Identities = 12/87 (13%), Positives = 28/87 (32%), Gaps = 10/87 (11%) Query: 196 KFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPL 255 + + + S D +K W + G + G + + D+LN Sbjct: 90 PYYSSNLTIATSSTDDSIKSWKDLKGKTL----------GAKNGTASFDYLNAHAKEYGY 139 Query: 256 VISGYENGDIYCWNSDTKSLLQLLDGS 282 + + + + + S+ L+D Sbjct: 140 TVKTFTDATTMYSSLNNGSINALMDDE 166 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.127 0.344 Lambda K H 0.267 0.0388 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,343,258 Number of Sequences: 36641 Number of extensions: 399587 Number of successful extensions: 5480 Number of sequences better than 10.0: 179 Number of HSP's better than 10.0 without gapping: 247 Number of HSP's successfully gapped in prelim test: 65 Number of HSP's that attempted gapping in prelim test: 1181 Number of HSP's gapped (non-prelim): 1224 length of query: 315 length of database: 10,336,785 effective HSP length: 97 effective length of query: 218 effective length of database: 6,782,608 effective search space: 1478608544 effective search space used: 1478608544 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 59 (27.4 bits)