BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P38074 (348 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1G6Q-1 nrPDB 677 0.0 6CU3-A nrPDB 336 9e-93 3Q7E-A nrPDB 329 1e-90 5DST-A nrPDB 325 1e-89 4RYL-A nrPDB 304 5e-83 1F3L-A nrPDB 298 3e-81 5LV5-A nrPDB 219 1e-57 5EGS-A nrPDB 218 4e-57 5JMQ-A nrPDB 216 9e-57 5FUB-A nrPDB 194 5e-50 5IS8-A nrPDB 191 3e-49 3B3J-A nrPDB 190 7e-49 4IKP-A nrPDB 188 3e-48 3R0Q-C nrPDB 164 5e-41 4LWO-B nrPDB 146 1e-35 6OGN-A nrPDB 73 1e-13 5EKU-A nrPDB 70 2e-12 4M36-A nrPDB 69 3e-12 3X0D-A nrPDB 65 5e-11 3SVZ-A nrPDB 52 5e-07 4G56-A nrPDB 45 5e-05 2AS0-A nrPDB 45 5e-05 3BKW-A nrPDB 45 6e-05 5JE5-A nrPDB 40 0.001 4PNE-A nrPDB 39 0.004 3CJR-A nrPDB 39 0.004 1VQ1-A nrPDB 38 0.005 5FA5-A nrPDB 38 0.006 4P7C-A nrPDB 38 0.007 5GM1-A nrPDB 38 0.008 4HTF-A nrPDB 37 0.009 4FS8-A nrPDB 37 0.009 1WY7-A nrPDB 36 0.021 1L3B-A nrPDB 36 0.026 2YXD-A nrPDB 36 0.030 4KIC-A nrPDB 35 0.033 5FAD-A nrPDB 35 0.038 3FYD-A nrPDB 35 0.039 3D2L-A nrPDB 35 0.047 2PJD-A nrPDB 35 0.049 6DCC-A nrPDB 35 0.051 3GRV-A nrPDB 35 0.053 5WP4-A nrPDB 35 0.055 2R3S-A nrPDB 35 0.067 4KDR-A nrPDB 35 0.070 4KRG-A nrPDB 35 0.071 5Z9O-A nrPDB 34 0.078 5WP5-A nrPDB 34 0.079 4KDC-A nrPDB 34 0.080 3CCF-A nrPDB 33 0.13 4FGZ-A nrPDB 33 0.17 4QNV-A nrPDB 33 0.23 4AZW-A nrPDB 33 0.25 3BKX-A nrPDB 32 0.28 3EGE-A nrPDB 32 0.29 3L8D-A nrPDB 32 0.31 3SM3-A nrPDB 32 0.31 3DMF-A nrPDB 32 0.33 2AVN-A nrPDB 32 0.34 5U19-A nrPDB 32 0.36 3LPM-A nrPDB 32 0.36 4AZV-A nrPDB 32 0.40 6BQC-A nrPDB 32 0.57 4QPN-A nrPDB 31 0.61 3DLC-A nrPDB 31 0.82 3HA5-A nrPDB 31 0.98 1DUS-A nrPDB 31 0.99 2H1R-A nrPDB 30 1.1 3JWI-A nrPDB 30 1.4 6J2X-P nrPDB 30 1.4 3G5T-A nrPDB 30 1.5 4JIJ-A nrPDB 30 1.9 1NKV-A nrPDB 30 2.0 2VS1-A nrPDB 30 2.2 1ZQ9-A nrPDB 29 2.7 5W0T-A nrPDB 29 3.3 3GK7-A nrPDB 29 3.4 4MTL-A nrPDB 29 3.5 5XJ2-A nrPDB 28 3.9 1UWV-A nrPDB 28 4.1 1RI1-A nrPDB 28 5.4 2ZLB-A nrPDB 28 5.8 6MRO-A nrPDB 28 6.3 6G4W-q nrPDB 28 6.9 3V8V-A nrPDB 28 7.4 4LEC-A nrPDB 28 8.6 3MGG-A nrPDB 28 8.7 >1G6Q-1 nrPDB Length = 328 Score = 677 bits (1747), Expect = 0.0, Method: Compositional matrix adjust. Identities = 325/327 (99%), Positives = 327/327 (100%) Query: 22 HYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA 81 +YF+SYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA Sbjct: 2 YYFDSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA 61 Query: 82 KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYE 141 KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYE Sbjct: 62 KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYE 121 Query: 142 SMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLV 201 SMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLV Sbjct: 122 SMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLV 181 Query: 202 LHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIV 261 LHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIV Sbjct: 182 LHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIV 241 Query: 262 FPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNI 321 FPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNI Sbjct: 242 FPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNI 301 Query: 322 KISYKFESNGIDGNSRSRKNEGSYLMH 348 KISYKFESNGIDGNSRSRKNEGSYLMH Sbjct: 302 KISYKFESNGIDGNSRSRKNEGSYLMH 328 >6CU3-A nrPDB Length = 336 Score = 336 bits (861), Expect = 9e-93, Method: Compositional matrix adjust. Identities = 163/306 (53%), Positives = 218/306 (71%), Gaps = 5/306 (1%) Query: 31 GIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS 90 GIHEEML+D +RT +Y+NAI+QNK LFKDK+VLD+GCGTGIL +FAAK GAK VIG+DMS Sbjct: 24 GIHEEMLKDGIRTNAYKNAILQNKHLFKDKVVLDIGCGTGILCLFAAKAGAKRVIGIDMS 83 Query: 91 SIIEMAKELVELNGFSDKITLLRGKLEDV-HLPF--PKVDIIISEWMGYFLLYESMMDTV 147 II+ A+++V NG+S I L++GK+ED+ LPF KVDIIISEWMGYFLLYESM+ TV Sbjct: 84 DIIDKARQIVSDNGYSHVIELIKGKVEDIAQLPFGIEKVDIIISEWMGYFLLYESMLQTV 143 Query: 148 LYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIV 207 L ARD +L GG +FPDKC++++ G+EDS+YK +K+++W +VYGF++S L EP+V Sbjct: 144 LSARDRWLRPGGYLFPDKCTMYICGIEDSEYKRDKIDFWDNVYGFNFSAIKADALREPLV 203 Query: 208 DTVERNNVNTTSDKLIEFDLNTVKISDL-AFKSNFKLTAKRQDMINGIVTWFDIVFPAPK 266 D VE + TT K +E DLNT++ DL ++F+ T++ Q+ V WFD VF Sbjct: 204 DFVESQQIITTQSKFLEIDLNTIQPEDLKQITTSFEFTSQYQEYCQAFVAWFDCVFSRGP 263 Query: 267 GKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYK 326 K PVEFSTGP THWKQT+FY +DL + D I+G + S N+ N+RDL+I + Y Sbjct: 264 HK-PVEFSTGPFTEGTHWKQTVFYLENDLPLKPNDVIKGTITISQNKSNHRDLDISMKYT 322 Query: 327 FESNGI 332 + Sbjct: 323 VNGGAV 328 >3Q7E-A nrPDB Length = 349 Score = 329 bits (843), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 157/312 (50%), Positives = 219/312 (70%), Gaps = 2/312 (0%) Query: 19 SEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAK 78 S+ +YF+SY H+GIHEE+L+D VRTL+YRN++ N+ LFKDK+VLDVG GTGIL MFAAK Sbjct: 27 SKDYYFDSYAHFGIHEELLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAK 86 Query: 79 HGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFL 138 GA+ VIG++ SSI + A ++V+ N +T+++GK+E+V LP KVDIIISEWMGY L Sbjct: 87 AGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCL 146 Query: 139 LYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFV 198 YESM++TVL+ARD +L GLIFPD+ ++++ +ED QYKD K+++W++VYGFD S Sbjct: 147 FYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIK 206 Query: 199 PLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWF 258 + + EP+VD V+ + T + + E D+ TVK+ DL F S F L KR D ++ +V +F Sbjct: 207 DVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYF 266 Query: 259 DIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRD 318 +I F + + FST P +PYTHWKQT+FY D L +TG+ I G + PN KNNRD Sbjct: 267 NIEF--TRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRD 324 Query: 319 LNIKISYKFESN 330 L+ I F+ Sbjct: 325 LDFTIDLDFKGQ 336 >5DST-A nrPDB Length = 332 Score = 325 bits (834), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 155/312 (49%), Positives = 219/312 (70%), Gaps = 2/312 (0%) Query: 19 SEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAK 78 S +YF+SY H+GIHEEML+D VRTL+YRN++ NK +FKDK+VLDVG GTGILSMFAAK Sbjct: 10 SRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAK 69 Query: 79 HGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFL 138 GAK V G++ SSI + ++++++ N + IT+ +GK+E+V LP KVDIIISEWMGY L Sbjct: 70 AGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCL 129 Query: 139 LYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFV 198 YESM++TV++ARD +L GGL+FPD+ ++++ +ED QYKD K+++W++VYGFD + Sbjct: 130 FYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIR 189 Query: 199 PLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWF 258 + + EP+VD V+ V T + + E D+ TVK +L+F S F L +R D ++ +VT+F Sbjct: 190 DVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYF 249 Query: 259 DIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRD 318 +I F K + + FST P APYTHWKQT+FY D L G+ I G + PN KN RD Sbjct: 250 NIEF--TKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRD 307 Query: 319 LNIKISYKFESN 330 L+ + F+ Sbjct: 308 LDFTVDLDFKGQ 319 >4RYL-A nrPDB Length = 340 Score = 304 bits (778), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 145/302 (48%), Positives = 199/302 (65%), Gaps = 1/302 (0%) Query: 23 YFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAK 82 YF+SY HYGIHEEML+D +RT SYR+ I QN +FKDK+VLDVGCGTGILSMFAAK GAK Sbjct: 29 YFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAK 88 Query: 83 HVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYES 142 V+GVD S I+ A +++ LN D ITL++GK+E+VHLP KVD+IISEWMGYFLL+ES Sbjct: 89 KVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFES 148 Query: 143 MMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVL 202 M+D+VLYA++ YL +GG ++PD C+I L + D +++ +W DVYGF S V+ Sbjct: 149 MLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVI 208 Query: 203 HEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVF 262 E +V+ ++ + + + D +T ISDL F S+F L R M I +FDI F Sbjct: 209 PEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYF 268 Query: 263 PAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIK 322 R V FSTGP + THWKQT+F + G+ ++G++ N+K+ R L + Sbjct: 269 EKNCHNRVV-FSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVT 327 Query: 323 IS 324 ++ Sbjct: 328 LT 329 >1F3L-A nrPDB Length = 321 Score = 298 bits (762), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 144/302 (47%), Positives = 196/302 (64%), Gaps = 1/302 (0%) Query: 23 YFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAK 82 YF+SY HYGIHEEML+D VRT SYR+ I QN +FKDK+VLDVGCGTGILSMFAAK GAK Sbjct: 10 YFSSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAK 69 Query: 83 HVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYES 142 VI VD S I+ A +++ LN D I L++GK+E+V LP KVD+IISEWMGYFLL+ES Sbjct: 70 KVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLPVEKVDVIISEWMGYFLLFES 129 Query: 143 MMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVL 202 M+D+VLYA+ YL +GG ++PD C+I L + D +++ +W DVYGF+ S V+ Sbjct: 130 MLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMSCMKKAVI 189 Query: 203 HEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVF 262 E +V+ V+ + + + D +T ISDL F S+F L + M + +FDI F Sbjct: 190 PEAVVEVVDHKTLISDPCDIKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAGYFDIYF 249 Query: 263 PAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIK 322 R V FSTGP + THWKQTIF + G+ ++G++ N+K+ R L + Sbjct: 250 EKNCHNRVV-FSTGPQSTKTHWKQTIFLLEKPFPVKAGEALKGKITVHKNKKDPRSLIVT 308 Query: 323 IS 324 ++ Sbjct: 309 LT 310 >5LV5-A nrPDB Length = 403 Score = 219 bits (559), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 120/326 (36%), Positives = 177/326 (54%), Gaps = 15/326 (4%) Query: 13 KTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGIL 72 +TK SE +Q Y+ Y +HEEM+ D VRT +YR I++N + K VLDVG GTGIL Sbjct: 66 RTK-SERDQLYYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGIL 124 Query: 73 SMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISE 132 S+F A+ GA+ V V+ S+I + A+E+V LNG D++ +L G +E V LP +VD I+SE Sbjct: 125 SIFCAQAGARRVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVELP-ERVDAIVSE 183 Query: 133 WMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDV--- 189 WMGY LL+ESM+ +VL+AR +L EGGL+ P + +A + D Q + +L +W V Sbjct: 184 WMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISD-QMLEWRLGFWSQVKQH 242 Query: 190 YGFDYS---PFVPLVL---HEPIVDTVERNNVNTTSDKLIEFDLNTVKIS---DLAFKSN 240 YG D S F L E +V + +V + + +L + + Sbjct: 243 YGVDMSCMESFATRCLMGHSEIVVQDLSGEDVLARPQRFAQLELARAGLEQELEAGVGGR 302 Query: 241 FKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETG 300 F+ + ++G WF + FP ++P+ ST P P THWKQ + Y + + E Sbjct: 303 FRCSCYGSAPLHGFAVWFQVTFPGGDSEKPLVLSTSPLHPATHWKQALLYLNEPVPVEQD 362 Query: 301 DTIEGELVCSPNEKNNRDLNIKISYK 326 I GE+ P+ N R L I + YK Sbjct: 363 TDISGEITLLPSPDNPRRLRILLRYK 388 >5EGS-A nrPDB Length = 376 Score = 218 bits (554), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 115/334 (34%), Positives = 181/334 (54%), Gaps = 16/334 (4%) Query: 7 KDSATEKTKLS--ESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLD 64 +++A E+ + + E +Q Y+ Y +HEEM+ D VRT +YR I++N + K VLD Sbjct: 30 REAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLD 89 Query: 65 VGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFP 124 VG GTGILS+F A+ GA+ V V+ S+I + A+E+V NG D++ +L G +E V LP Sbjct: 90 VGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELP-E 148 Query: 125 KVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLN 184 +VD I+SEWMGY LL+ESM+ +VL+AR +L EGGL+ P + + + D Q + +L Sbjct: 149 QVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISD-QMLEWRLG 207 Query: 185 YWQDV---YGFDYSP---FVPLVL---HEPIVDTVERNNVNTTSDKLIEFDLNTVKIS-- 233 +W V YG D S F L E +V + +V + + +L+ + Sbjct: 208 FWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQE 267 Query: 234 -DLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFP 292 + F+ + ++G WF + FP + ++P+ ST P P THWKQ + Y Sbjct: 268 LEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLN 327 Query: 293 DDLDAETGDTIEGELVCSPNEKNNRDLNIKISYK 326 + + E + GE+ P+ N R L + + YK Sbjct: 328 EPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYK 361 >5JMQ-A nrPDB Length = 446 Score = 216 bits (551), Expect = 9e-57, Method: Compositional matrix adjust. Identities = 117/327 (35%), Positives = 185/327 (56%), Gaps = 12/327 (3%) Query: 20 EQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKH 79 ++ YF+SY +H EML D RT Y + I+QNK+ KDK++LDVGCGTGI+S+F A H Sbjct: 112 DEEYFDSYGTLKLHLEMLADQPRTTKYHSVILQNKESLKDKVILDVGCGTGIISLFCAHH 171 Query: 80 G-AKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFL 138 K V V+ S + + +LV NGF+D IT+ + K+EDV LP KVD+++SEWMG L Sbjct: 172 ARPKAVYAVEASDMAQHTSQLVLQNGFADTITVFQQKVEDVVLP-EKVDVLVSEWMGTCL 230 Query: 139 LYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFV 198 L+E M++++LYARD +L G+I+P ++HL + K+ +W + Y F+ S Sbjct: 231 LFEFMIESILYARDTWLKGDGIIWPTTAALHLVPCSAEKDYHSKVLFWDNAYEFNLSALK 290 Query: 199 PLVLHEPIVDTVERNNVNTTSDKL------IEFDLNTVKISDL-AFKSNFKLTAKRQDMI 251 L + E + N++ D L ++ D+ TV++ DL + + ++ + Sbjct: 291 SLAIKE-FFSRPKSNHILKPEDCLSEPCTILQLDMRTVQVPDLETMRGELRFDIQKAGTL 349 Query: 252 NGIVTWFDIVFPAPKGKRPVE-FSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCS 310 +G WF + F + + +P + STGP P THWKQT+F D + TGD + G +V Sbjct: 350 HGFTAWFSVYFQSLEEGQPQQVLSTGPLHPTTHWKQTLFMMDDPVPVHTGDVVTGSVVLQ 409 Query: 311 PNEKNNRDLNIKISYKFESNGIDGNSR 337 N R +++ +S+ S +D S+ Sbjct: 410 RNPVWRRHMSVSLSWVVTS-ALDPTSQ 435 >5FUB-A nrPDB Length = 337 Score = 194 bits (493), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 105/318 (33%), Positives = 172/318 (54%), Gaps = 9/318 (2%) Query: 23 YFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG-A 81 YF +Y +H EML D RT +YR I+ N ++K+VLD+GCGTG++S+F A Sbjct: 9 YFGNYGTLRLHLEMLSDKPRTETYRQVILSNSAALREKVVLDLGCGTGVISLFCALLAKP 68 Query: 82 KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYE 141 V V+ SS+ E +ELV+ NG +T+ + + E++ LP KVD+++SEWMG LL+E Sbjct: 69 AGVYAVEASSMAEHTEELVKQNGCDGVVTVFQERAENLTLP-TKVDVLVSEWMGNCLLFE 127 Query: 142 SMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLV 201 M+++VL ARD +L +GG+++P + + + +K+ +W++ YG ++S L Sbjct: 128 YMLESVLLARDRWLKKGGMMWPSSACLTIVPCQAFSDYRQKVEFWENPYGLNFSYLQSLA 187 Query: 202 LHEPIVDT-----VERNNVNTTSDKLIEFDLNTVKISDLA-FKSNFKLTAKRQDMINGIV 255 E + ++ + +T +I D+ T+++SDL K F T ++ M +G Sbjct: 188 QKEFLSKPKFSHHLQPEDCLSTPADVITLDMVTIQVSDLERLKGEFTFTVEKSGMFHGFT 247 Query: 256 TWFDIVFPAPKGKRP-VEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEK 314 WF F + P +E +TGP++ THWKQT+F + E GD I G + N Sbjct: 248 VWFSAHFQCLEEDGPSIELNTGPYSEITHWKQTLFMLDAPVSVEEGDIIAGSIRLQRNPI 307 Query: 315 NNRDLNIKISYKFESNGI 332 R L+I + S + Sbjct: 308 WRRHLSITFLWNINSTEV 325 >5IS8-A nrPDB Length = 381 Score = 191 bits (486), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 124/337 (36%), Positives = 181/337 (53%), Gaps = 28/337 (8%) Query: 1 MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDK 60 M T + +E+T+ S + Q YF Y + + M+QD VRT +Y+ AI+QN FKDK Sbjct: 3 MGHTLERSVFSERTEESSAVQ-YFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDK 61 Query: 61 IVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVH 120 IVLDVGCG+GILS FAA+ GA+ + V+ S++ + A+ LV+ N +D+I ++ GK+E+V Sbjct: 62 IVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVS 121 Query: 121 LPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKD 180 LP +VDIIISE MGY L E M+++ L+A+ YL G +FP +HLA D Q Sbjct: 122 LP-EQVDIIISEPMGYMLFNERMLESYLHAKK-YLKPSGNMFPTIGDVHLAPFTDEQLYM 179 Query: 181 E---KLNYW--QDVYGFDYSPF----VPLVLHEPIVDTVERNNVNTTSDKLI-------E 224 E K N+W +G D S V +P+VDT + + S K E Sbjct: 180 EQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKE 239 Query: 225 FDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHW 284 DL+ ++I FK +++G+ WFD+ F V ST P P THW Sbjct: 240 GDLHRIEIP-------FKFHMLHSGLVHGLAFWFDVAFIG--SIMTVWLSTAPTEPLTHW 290 Query: 285 KQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNI 321 Q F L A+ GDT+ G + N++ + D++I Sbjct: 291 YQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISI 327 >3B3J-A nrPDB Length = 480 Score = 190 bits (483), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 122/327 (37%), Positives = 178/327 (54%), Gaps = 28/327 (8%) Query: 11 TEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTG 70 +E+T+ S + Q YF Y + + M+QD VRT +Y+ AI+QN FKDKIVLDVGCG+G Sbjct: 112 SERTEESSAVQ-YFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSG 170 Query: 71 ILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIII 130 ILS FAA+ GA+ + V+ S++ + A+ LV+ N +D+I ++ GK+E+V LP +VDIII Sbjct: 171 ILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLP-EQVDIII 229 Query: 131 SEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDE---KLNYW- 186 SE MGY L E M+++ L+A+ YL G +FP +HLA D Q E K N+W Sbjct: 230 SEPMGYMLFNERMLESYLHAKK-YLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWY 288 Query: 187 -QDVYGFDYSPF----VPLVLHEPIVDTVERNNVNTTSDKLI-------EFDLNTVKISD 234 +G D S V +P+VDT + + S K E DL+ ++I Sbjct: 289 QPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIP- 347 Query: 235 LAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDD 294 FK +++G+ WFD+ F V ST P P THW Q F Sbjct: 348 ------FKFHMLHSGLVHGLAFWFDVAFIG--SIMTVWLSTAPTEPLTHWYQVRCLFQSP 399 Query: 295 LDAETGDTIEGELVCSPNEKNNRDLNI 321 L A+ GDT+ G + N++ + D++I Sbjct: 400 LFAKAGDTLSGTCLLIANKRQSYDISI 426 >4IKP-A nrPDB Length = 341 Score = 188 bits (478), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 119/319 (37%), Positives = 171/319 (53%), Gaps = 27/319 (8%) Query: 19 SEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAK 78 S YF Y + + M+QD VRT +Y+ AI+QN FKDKIVLDVGCG+GILS FAA+ Sbjct: 6 SAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQ 65 Query: 79 HGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFL 138 GA+ + V+ S++ + A+ LV+ N +D+I ++ GK+E+V LP +VDIIISE MGY L Sbjct: 66 AGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLP-EQVDIIISEPMGYML 124 Query: 139 LYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDE---KLNYW--QDVYGFD 193 E M+++ L+A+ YL G +FP +HLA D Q E K N+W +G D Sbjct: 125 FNERMLESYLHAKK-YLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVD 183 Query: 194 YSPF----VPLVLHEPIVDTVERNNVNTTSDKLI-------EFDLNTVKISDLAFKSNFK 242 S V +P+VDT + + S K E DL+ ++I FK Sbjct: 184 LSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIP-------FK 236 Query: 243 LTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDT 302 +++G+ WFD+ F V ST P P THW Q F L A+ GDT Sbjct: 237 FHMLHSGLVHGLAFWFDVAFIG--SIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDT 294 Query: 303 IEGELVCSPNEKNNRDLNI 321 + G + N++ + D++I Sbjct: 295 LSGTCLLIANKRQSYDISI 313 >3R0Q-C nrPDB Length = 376 Score = 164 bits (416), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 110/344 (31%), Positives = 179/344 (52%), Gaps = 41/344 (11%) Query: 22 HYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA 81 YF +Y ++ML D VR +Y NA+ QNK F+ K VLDVG G+GIL++++A+ GA Sbjct: 27 QYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGA 86 Query: 82 KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYE 141 + V V+ + + + A+ LV+ N + ++ G +ED+ LP KVD+IISEWMGYFLL E Sbjct: 87 RKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWMGYFLLRE 145 Query: 142 SMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLN-------YWQDV----- 189 SM D+V+ ARD +L G+++P + LA ++ S D K N W + Sbjct: 146 SMFDSVISARDRWLKPTGVMYPSHARMWLAPIK-SNIADRKRNDFDGAMADWHNFSDEIK 204 Query: 190 --YGFDYSPFVPLVLHEPIVDTVERNNVNT-------------TSDKLIEFDLNTVKISD 234 YG D VL +P + E+ + T T + E D T +S+ Sbjct: 205 SYYGVDMG-----VLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSE 259 Query: 235 L-AFKSNF-KLTAKRQDMINGIVTWFDIVFPAPK---GKRPVEFSTGPHAPY-THWKQTI 288 + +SN + + G WFD+ F K ++ +E +T P + THW Q + Sbjct: 260 IEEVRSNVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQV 319 Query: 289 FYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKF-ESNG 331 F + ++ E GD + L+ S +++N+R + I+++ + E++G Sbjct: 320 FIMSNPINVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASG 363 >4LWO-B nrPDB Length = 368 Score = 146 bits (369), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 106/349 (30%), Positives = 167/349 (47%), Gaps = 59/349 (16%) Query: 21 QHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG 80 Y+ SY +H ML+D R YR +I Q+ + + K+V+DVG GTGILSM+AA+ G Sbjct: 18 HQYYESYSDLAVHRLMLEDAQRMSFYRKSIEQSASI-EGKVVVDVGSGTGILSMWAARAG 76 Query: 81 AKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDV--------------HLPFPKV 126 AKHV ++ SS+ E +VE N S KIT+L +E++ L V Sbjct: 77 AKHVFSIEASSLSEFQIGVVEDNDLSTKITVLGDTVENIIAGGVANFVNRHKAKLGKCGV 136 Query: 127 DIIISEWMGYFLLYESMMDTVLYARDHYL-VEGGL-------IFPDKCSIHLAGLEDSQY 178 +++SEWMG++L +E M+ +V+ AR+ + V L + P++ ++ +A + Y Sbjct: 137 AVLLSEWMGFYLFHEGMLPSVIRARNFFQDVNAALGVLQPIEMIPERATVFVAPITCKPY 196 Query: 179 KDEKL-NYWQDVYGFDYSPF------VPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVK 231 ++ N+W+DV G D+S + V L P+V+ + + LIE +L+TV+ Sbjct: 197 YVQRYKNFWRDVDGLDFSRYGRIEYEVYLEQASPLVECLPPLCLLHEGLSLIELNLSTVQ 256 Query: 232 IS-----------DLAFKSNFKLTAKRQD-----MINGIVTWFDIVFPAPKGKRPVEFST 275 DL + F+ A+ ++G WFD+ + A ST Sbjct: 257 EEVLTSLHNTVHFDLKESAEFQQHAREAGSEGRVSVDGFTVWFDVSYGAHT------LST 310 Query: 276 GPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKIS 324 P +P THWKQT P + E ELV P E + + IS Sbjct: 311 SPRSPSTHWKQTTILLPREARNE-------ELVSFPVEGGELGVEMHIS 352 >6OGN-A nrPDB Length = 692 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 79/314 (25%), Positives = 133/314 (42%), Gaps = 58/314 (18%) Query: 28 DHYGIHEE--------MLQDTVRTLSY----RNAIIQNKDLFKDKIVLDVGCGTGILSMF 75 +HY H+E ML D R + Y R A+ + KD + +VLD+G GTG+LSM Sbjct: 22 EHYDYHQEIARSSYADMLHDKDRNIKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMM 81 Query: 76 AAKHGAKHVIGVDM-SSIIEMAKELVELNGFSDKITLLRGKLEDV------HLPFPKVDI 128 A GA +++ + E A ++VE NGFSDKI ++ +V LP + +I Sbjct: 82 AVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINKHSTEVTVGPDGDLPC-RANI 140 Query: 129 IISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQD 188 +I+E L+ E + + +A H + E P + +++ +E ++ W Sbjct: 141 LITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVE-----SRRMWSWNK 195 Query: 189 VY------GFDYSPFVPLVLHE-----PIVDTVERNNVNTT-----SDKLIEFDLN---T 229 ++ VP E P V ++ N V+ SD L F ++ Sbjct: 196 LFPVRVRTSLGEQVIVPPSELERCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSVDFSKQ 255 Query: 230 VKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYT------- 282 V S F A Q + +++W+DI P+GK ++ + P T Sbjct: 256 VSSSAACHSRQFVPLASGQAQV--VLSWWDIEM-DPEGK--IKCTMAPFWAQTDPQELQW 310 Query: 283 --HWKQTIFYFPDD 294 HW Q +++ P + Sbjct: 311 RDHWMQCVYFLPQE 324 >5EKU-A nrPDB Length = 390 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 116/238 (48%), Gaps = 13/238 (5%) Query: 33 HEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-S 91 H M+ D R Y + K + + VL++G G+G+LS+ AAK GAK V+ V+ S Sbjct: 72 HYAMMNDEERNNFYYEVL--KKHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGSEE 129 Query: 92 IIEMAKELVELNGFSDKITLLR---GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVL 148 + ++A+E + N ++ +L +L+ HLP P D+++SE G +L ES +D V+ Sbjct: 130 LAKLARENIRANNMEHQVKVLHMMSTELKPKHLPEPP-DVLLSEIFGTMMLGESALDYVV 188 Query: 149 YARDHYLVEGGLIFPDKCSIHLAGLE-DSQYKDEKLNYWQDV---YGFDYSPFVPLVLHE 204 R+ L I P + + +E D+ ++ ++ W+D+ + V +V + Sbjct: 189 DVRNRLLKPTTKIIPQFGTQYAVPIECDALHRISSVSGWRDLDLKHMMTLQDTVSIVFAK 248 Query: 205 PIVDTVERNNVNTTSD--KLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDI 260 + N SD +L D ++ +D++ + +F + AK + ++ ++ + Sbjct: 249 HYGIRMNSVNFRRLSDPIELFRVDFSSSNRNDISRRKHFDVVAKESGTAHAMLFYWKV 306 >4M36-A nrPDB Length = 343 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 115/238 (48%), Gaps = 13/238 (5%) Query: 33 HEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-S 91 H M+ D R Y + K + + VL++G G+G+LS+ AAK GAK V+ V+ S Sbjct: 37 HYAMMNDEERNNFYYEVL--KKHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGSEE 94 Query: 92 IIEMAKELVELNGFSDKITLLR---GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVL 148 + ++A+E + N ++ +L +L+ HLP P D+++SE G +L ES +D V+ Sbjct: 95 LAKLARENIRANNMEHQVKVLHMMSTELKSKHLPEPP-DVLLSEIFGTMMLGESALDYVV 153 Query: 149 YARDHYLVEGGLIFPDKCSIHLAGLE-DSQYKDEKLNYWQDV---YGFDYSPFVPLVLHE 204 R+ L I P + + +E D+ ++ ++ W+D+ + V +V + Sbjct: 154 DVRNRLLKPTTKIIPQFGTQYAVPIECDALHRISSVSGWRDLDLKHMMTLQDTVSIVFAK 213 Query: 205 PIVDTVERNNVNTTSD--KLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDI 260 + N SD +L D ++ +D+ + +F + AK + ++ ++ + Sbjct: 214 HYGIRMNSVNFRRLSDPIELFRVDFSSSNRNDIPRRKHFDVVAKESGTAHAMLFYWKV 271 >3X0D-A nrPDB Length = 655 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 62/269 (23%), Positives = 118/269 (43%), Gaps = 25/269 (9%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFSDKITLLRGKLEDV- 119 VLD+G GTG+LS+ AA+ GA V +++ + + A+ + + +SDKIT++ + DV Sbjct: 76 VLDIGTGTGLLSLMAAREGADKVTALEVFKPMGDCARHITSNSPWSDKITVISERSTDVS 135 Query: 120 HLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYK 179 + + DII++E L+ E + T A + G + P ++++ +E K Sbjct: 136 QIGGSRADIIVAEVFDTELIGEGALRTFKEALERLAKPGCRVVPSTGNVYIVPVESHLLK 195 Query: 180 D----EKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDL 235 +LN +D V + + ++ + S+ ++ F + + Sbjct: 196 MFNDIPRLNGEKDEEPLGRCSGTAAVFDVQLSE-MKTHEFRELSEPIVAFKFDFEHEEKI 254 Query: 236 AFKSNF--KLTAKRQDMINGIVTWFDI---------VFPAPKGKRPVEFSTGPHAPYTHW 284 F +F + A I+ ++ W+DI + PK K + +A HW Sbjct: 255 IFDESFVREAVAHSSGTIDALLMWWDIDMDRNGTTFIDMGPKWK-----NKNNYAWRDHW 309 Query: 285 KQTIFYFPDDLDAETGDTIEGELVCSPNE 313 Q ++Y P+ E T E+VC+ +E Sbjct: 310 MQAVYYLPEKKKVEMNQTF--EIVCNHDE 336 >3SVZ-A nrPDB Length = 263 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%) Query: 47 RNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGF 105 R A+ +L D + D+GCGTG ++F A + + G+D+ IE+ E Sbjct: 41 RKAVSFINELTDDAKIADIGCGTGGQTLFLADYVKGQITGIDLFPDFIEIFNENAVKANC 100 Query: 106 SDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDK 165 +D++ + G ++++ ++D+I SE Y + +E M+ YL +GG I Sbjct: 101 ADRVKGITGSMDNLPFQNEELDLIWSEGAIYNIGFERGMNEW----SKYLKKGGFI---- 152 Query: 166 CSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTS 219 ++ A S+ E ++W D Y P + ++ +D +ER T+ Sbjct: 153 -AVSEASWFTSERPAEIEDFWMDAY-----PEISVI--PTCIDKMERAGYTPTA 198 >4G56-A nrPDB Length = 657 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 58/253 (22%), Positives = 101/253 (39%), Gaps = 34/253 (13%) Query: 60 KIVLDVGCGTGIL---SMFAAKHGAKH--VIGVDMSSIIEMAKELVELNGFSDKITLLRG 114 +I++ +G G G L S+ AAK + V V+ + + E + ++T++ G Sbjct: 379 QILMVLGAGRGPLVNASLRAAKQAERKIKVYAVEKNPNAVITLEGWRYEEWGSQVTVVSG 438 Query: 115 KLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLE 174 + + P K DII+SE +G F E + L H+L + G+ P + + +LA + Sbjct: 439 DMREWKAP-EKADIIVSELLGSFGDNE-LSPECLDGAQHFLKDDGVSIPGEYTSYLAPIS 496 Query: 175 DSQYKDE---------------KLNYWQDVYGFDY--SPFVPLVLHEPIVDTVERNNVNT 217 S+ +E ++ Y ++ F P H P D V NN Sbjct: 497 SSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSDPLPCFTFHHPNKDDVIDNNRYC 556 Query: 218 TSDKLIEFDLNTV-----KISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVE 272 + DLNTV + + L+ + G+ +WF I+FP K+P+ Sbjct: 557 CLQYRV--DLNTVLHGFAGYFNTVLYKDVTLSICPESHSPGMFSWFPILFPI---KQPIP 611 Query: 273 FSTGPHAPYTHWK 285 G W+ Sbjct: 612 MREGDTVCVRFWR 624 >2AS0-A nrPDB Length = 396 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 38/121 (31%), Positives = 61/121 (50%), Gaps = 13/121 (10%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELVELNGFSDKITLLRG----KL 116 VLDV TG ++ AA GA VIG+D S IE AKE +LNG D++ + G ++ Sbjct: 221 VLDVFTYTGGFAIHAAIAGADEVIGIDKSPRAIETAKENAKLNGVEDRMKFIVGSAFEEM 280 Query: 117 EDVHLPFPKVDIIISEWMGYFLLYESMMDTVL-------YARDHYLVEGGLIFPDKCSIH 169 E + K DI++ + F+ +E + L +A + + +GG++ CS H Sbjct: 281 EKLQKKGEKFDIVVLDPPA-FVQHEKDLKAGLRAYFNVNFAGLNLVKDGGILVTCSCSQH 339 Query: 170 L 170 + Sbjct: 340 V 340 >3BKW-A nrPDB Length = 243 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 31/109 (28%), Positives = 47/109 (43%), Gaps = 7/109 (6%) Query: 23 YFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAK 82 +F Y G E L + R + + L ++D+GCG G +A +HGA Sbjct: 12 FFAGYSQLGRSIEGLDGAAEWPALRAMLPEVGGL----RIVDLGCGFGWFCRWAHEHGAS 67 Query: 83 HVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIIS 131 +V+G+D+S E G IT R L+ +HLP D+ S Sbjct: 68 YVLGLDLS---EKMLARARAAGPDTGITYERADLDKLHLPQDSFDLAYS 113 >5JE5-A nrPDB Length = 247 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 6/106 (5%) Query: 31 GIHEEMLQDTV-RTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM 89 G+ E+ Q R + R D+ K VLD+ CG G + GA V+GVD+ Sbjct: 14 GLFEDFTQSAAQRAIEVRTIFHMIGDV-SGKSVLDLACGFGFFGREIYRRGAAKVVGVDI 72 Query: 90 S-SIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWM 134 S +IE+A+E E + D + + ++ P + D++ + W+ Sbjct: 73 SEKMIELARE--ESRKYGDPLEFHVRDVANME-PLGQFDLVNAAWL 115 >4PNE-A nrPDB Length = 302 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 31/125 (24%), Positives = 57/125 (45%), Gaps = 11/125 (8%) Query: 45 SYRNAIIQNKDLFKDKIVLD-------VGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMA 96 S++ A + DL ++ VLD VGCGTG ++ A+ A + G+ +S + + +A Sbjct: 72 SWQQAADRLTDLVAERTVLDGGVRLLDVGCGTGQPALRVARDNAIQITGITVSQVQVAIA 131 Query: 97 KELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLV 156 + G S ++ ++ + LP+P + + W LL S D + L Sbjct: 132 ADCARERGLSHRVDF--SCVDAMSLPYPD-NAFDAAWAMQSLLEMSEPDRAIREILRVLK 188 Query: 157 EGGLI 161 GG++ Sbjct: 189 PGGIL 193 >3CJR-A nrPDB Length = 254 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 11/99 (11%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKLEDVH 120 VLD+G G+G+L++ A K G K +GVD+ ++ A+ + NG + L G LE Sbjct: 124 VLDLGTGSGVLAIAAEKLGGK-ALGVDIDPMVLPQAEANAKRNGVRPRF--LEGSLE-AA 179 Query: 121 LPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGG 159 LPF D++++ LY + + LV GG Sbjct: 180 LPFGPFDLLVAN------LYAELHAALAPRYREALVPGG 212 >1VQ1-A nrPDB Length = 294 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 24/74 (32%), Positives = 42/74 (56%), Gaps = 2/74 (2%) Query: 60 KIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGK-LE 117 K V D+G G+G + + AK V D+SS +E+A++ E +G SD+ + +G+ LE Sbjct: 135 KTVADIGTGSGAIGVSVAKFSDAIVFATDVSSKAVEIARKNAERHGVSDRFFVRKGEFLE 194 Query: 118 DVHLPFPKVDIIIS 131 F +++I+S Sbjct: 195 PFKEKFASIEMILS 208 >5FA5-A nrPDB Length = 650 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 53/253 (20%), Positives = 103/253 (40%), Gaps = 34/253 (13%) Query: 60 KIVLDVGCGTGIL---SMFAAKHGAKHV--IGVDMSSIIEMAKELVELNGFSDKITLLRG 114 ++++ +G G G L S+ AAK + + V+ + + E + + ++T++ Sbjct: 372 QVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSS 431 Query: 115 KLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLE 174 + + P K DII+SE +G F E + L H+L + G+ P + + LA + Sbjct: 432 DMREWVAP-EKADIIVSELLGSFADNE-LSPECLDGAQHFLKDDGVSIPGEYTSFLAPIS 489 Query: 175 DSQYKDE---------------KLNYWQDVYGFDY--SPFVPLVLHEPIVDTVERNNVNT 217 S+ +E ++ Y ++ F +P P D + NN Sbjct: 490 SSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYC 549 Query: 218 TSDKLIEFDLNTV-----KISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVE 272 T + +E +NTV + + L+ + + G+ +WF I+FP K+P+ Sbjct: 550 TLEFPVE--VNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPI---KQPIT 604 Query: 273 FSTGPHAPYTHWK 285 G W+ Sbjct: 605 VREGQTICVRFWR 617 >4P7C-A nrPDB Length = 322 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 36/108 (33%), Positives = 48/108 (44%), Gaps = 13/108 (12%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSII-----EMAKELVELNGFSDKITL 111 K K VLDVGCG G GA VIGVD + + M + L +L + Sbjct: 120 LKGKRVLDVGCGNGYYQWRMLGAGADSVIGVDPNWLFFCQFQAMQRYLPDLPAWH----- 174 Query: 112 LRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGG 159 L LED+ D + S MG +S +D +L +D LV+GG Sbjct: 175 LPFALEDLPANLEGFDTVFS--MGVLYHRKSPIDHLLALKD-CLVKGG 219 >5GM1-A nrPDB Length = 297 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 1/67 (1%) Query: 46 YRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELVELNG 104 Y + +I+ D + +LD+GCGTG ++ AA+ V GV +S I A L +G Sbjct: 65 YTDYLIETLDPKAGQHLLDIGCGTGRTALKAARQRGIAVTGVAVSKEQIAAANRLAAGHG 124 Query: 105 FSDKITL 111 ++++T Sbjct: 125 LTERLTF 131 >4HTF-A nrPDB Length = 285 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 9/81 (11%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKLEDV- 119 VLD G G G ++ A+ G VI D+S+ +I+ AK+ E G SD + + +DV Sbjct: 72 VLDAGGGEGQTAIKMAERG-HQVILCDLSAQMIDRAKQAAEAKGVSDNMQFIHCAAQDVA 130 Query: 120 -HLPFPKVDII----ISEWMG 135 HL P VD+I + EW+ Sbjct: 131 SHLETP-VDLILFHAVLEWVA 150 >4FS8-A nrPDB Length = 383 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 30/91 (32%), Positives = 47/91 (51%), Gaps = 20/91 (21%) Query: 62 VLDVGCGTG----ILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNG-------FSDKI 109 VLD+GCGTG + S +HG VIGVDM + +E+A++ VE + + Sbjct: 87 VLDLGCGTGRDVYLASKLVGEHG--KVIGVDMLDNQLEVARKYVEYHAEKFFGSPSRSNV 144 Query: 110 TLLRGKLEDVH------LPFPKVDIIISEWM 134 L+G +E++ +P VDI+IS + Sbjct: 145 RFLKGFIENLATAEPEGVPDSSVDIVISNCV 175 >1WY7-A nrPDB Length = 207 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 27/72 (37%), Positives = 39/72 (54%), Gaps = 6/72 (8%) Query: 60 KIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVE-LNGFSDKITLLRGKLED 118 K+V D+G GTG+LS A GAK VI V++ E L+E L F K + G + + Sbjct: 51 KVVADLGAGTGVLSYGALLLGAKEVICVEVDK--EAVDVLIENLGEFKGKFKVFIGDVSE 108 Query: 119 VHLPFPKVDIII 130 + +VDI+I Sbjct: 109 FN---SRVDIVI 117 >1L3B-A nrPDB Length = 192 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 23/94 (24%), Positives = 44/94 (46%), Gaps = 2/94 (2%) Query: 43 TLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELVE 101 + R I+ + K+ + +DVGCGTG +++ A + V +D + I + ++ Sbjct: 18 AMEVRCLIMCLAEPGKNDVAVDVGCGTGGVTLELAGR-VRRVYAIDRNPEAISTTEMNLQ 76 Query: 102 LNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMG 135 +G D +TL+ G + P +DI + G Sbjct: 77 RHGLGDNVTLMEGDAPEALCKIPDIDIAVVGGSG 110 >2YXD-A nrPDB Length = 183 Score = 35.8 bits (81), Expect = 0.030, Method: Compositional matrix adjust. Identities = 25/67 (37%), Positives = 41/67 (61%), Gaps = 5/67 (7%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVD-MSSIIEMAKELVELNGFSDK-ITLL 112 +L KD +V+DVGCG+G +++ AK K V +D + IE+ K+ L F+ K ++ Sbjct: 32 NLNKDDVVVDVGCGSGGMTVEIAKR-CKFVYAIDYLDGAIEVTKQ--NLAKFNIKNCQII 88 Query: 113 RGKLEDV 119 +G+ EDV Sbjct: 89 KGRAEDV 95 >4KIC-A nrPDB Length = 357 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 29/101 (28%), Positives = 49/101 (48%), Gaps = 8/101 (7%) Query: 62 VLDVGCGTG-ILSMFAAKHGAKHVIGVDMS-SIIEMAKELVELNGFSDKITLLRGKLEDV 119 V D+G G+G L A + +GVD++ I MA++ V GF D+I+ +RG + Sbjct: 182 VADLGSGSGERLIQIARRFPGVRGLGVDIADGAIAMAEKEVAAKGFGDQISFVRGDARTI 241 Query: 120 -----HLPFPKVDIIISEWMGY-FLLYESMMDTVLYARDHY 154 F +VD++ MG+ F E+ + T+ R + Sbjct: 242 DQVSARGEFAEVDLLTCFMMGHDFWPRENCVQTLRKLRAAF 282 >5FAD-A nrPDB Length = 161 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 27/84 (32%), Positives = 45/84 (53%), Gaps = 9/84 (10%) Query: 58 KDKIVLDVGCGTGILSMFAAK-HGAKHVIGVDMS-SIIEMAKELVELNGFSDKITLLRGK 115 +D IV D+GCG G + + AAK K +GV+++ I A +E NG + + ++++G Sbjct: 28 QDDIVYDLGCGDGRIIITAAKDFNVKKAVGVEINDERIREALANIEKNGVTGRASIVKGN 87 Query: 116 LEDVHLPFPKVDIIISEWMGYFLL 139 F +VDI + + FLL Sbjct: 88 -------FFEVDISEATVVTMFLL 104 >3FYD-A nrPDB Length = 263 Score = 35.4 bits (80), Expect = 0.039, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 31/47 (65%), Gaps = 1/47 (2%) Query: 45 SYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAK-HVIGVDMS 90 ++ N +++ +L KD +VL++G G GIL+ AK+ K +VI +D S Sbjct: 8 NFVNKAVESANLTKDDVVLEIGLGKGILTEELAKNAKKVYVIEIDKS 54 >3D2L-A nrPDB Length = 243 Score = 35.0 bits (79), Expect = 0.047, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 57/107 (53%), Gaps = 12/107 (11%) Query: 26 SYDHYG-IHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHV 84 +Y+ + +++E++QD V + +++ + K + D+GCGTG ++ A H V Sbjct: 3 AYEQFAYVYDELMQD-VPYPEWVAWVLEQVE--PGKRIADIGCGTGTATLLLADH--YEV 57 Query: 85 IGVDMS-SIIEMAKE-LVELNGFSDKITLLRGKLEDVHLPFPKVDII 129 GVD+S ++E+A+E +E N D + ++ LP P VD I Sbjct: 58 TGVDLSEEMLEIAQEKAMETNRHVD---FWVQDMRELELPEP-VDAI 100 >2PJD-A nrPDB Length = 343 Score = 35.0 bits (79), Expect = 0.049, Method: Compositional matrix adjust. Identities = 18/50 (36%), Positives = 30/50 (60%), Gaps = 2/50 (4%) Query: 62 VLDVGCGTGILSMFAAKHGAK-HVIGVDMSS-IIEMAKELVELNGFSDKI 109 VLDVGCG G+LS+ A+H K + D+S+ +E ++ + NG ++ Sbjct: 200 VLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATLAANGVEGEV 249 >6DCC-A nrPDB Length = 309 Score = 35.0 bits (79), Expect = 0.051, Method: Compositional matrix adjust. Identities = 24/87 (27%), Positives = 42/87 (48%), Gaps = 11/87 (12%) Query: 15 KLSESEQHYFNSYDHYGIHEEMLQD-TVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILS 73 K + + Y N +YG +D +R L + F+ + VLD+GC G L+ Sbjct: 27 KKQQRKFQYGNYCKYYGYRNPSCEDGRLRVL--------KPEWFRGRDVLDLGCNVGHLT 78 Query: 74 M-FAAKHGAKHVIGVDM-SSIIEMAKE 98 + A K G ++G+D+ S +I A++ Sbjct: 79 LSIACKWGPSRMVGLDIDSRLIHSARQ 105 >3GRV-A nrPDB Length = 295 Score = 35.0 bits (79), Expect = 0.053, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 31/47 (65%), Gaps = 1/47 (2%) Query: 45 SYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAK-HVIGVDMS 90 ++ N +++ +L KD +VL++G G GIL+ AK+ K +VI +D S Sbjct: 37 NFVNKAVESANLTKDDVVLEIGLGKGILTEELAKNAKKVYVIEIDKS 83 >5WP4-A nrPDB Length = 491 Score = 34.7 bits (78), Expect = 0.055, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 45/104 (43%), Gaps = 15/104 (14%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELVELNGFSDK 108 ++ +L + VLDVGCG G + A+ HV+G+D+S ++I A L G S Sbjct: 274 FVEKMNLKPGQKVLDVGCGIGGGDFYMAEKFDVHVVGIDLSVNMISFA--LERAIGLSCS 331 Query: 109 ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARD 152 + H P D+I S DT+L+ +D Sbjct: 332 VEFEVADCTTKHYPDNSFDVIYSR------------DTILHIQD 363 >2R3S-A nrPDB Length = 335 Score = 34.7 bits (78), Expect = 0.067, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 31/59 (52%), Gaps = 1/59 (1%) Query: 62 VLDVGCGTGILSMFAAKHGA-KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDV 119 VLD+ G+ + A+H + GVD +S++E+AKE + G + + + G +V Sbjct: 169 VLDISASHGLFGIAVAQHNPNAEIFGVDWASVLEVAKENARIQGVASRYHTIAGSAFEV 227 >4KDR-A nrPDB Length = 223 Score = 34.7 bits (78), Expect = 0.070, Method: Compositional matrix adjust. Identities = 18/31 (58%), Positives = 21/31 (67%), Gaps = 1/31 (3%) Query: 60 KIVLDVGCGTGILSMFAAKHGAKHVIGVDMS 90 K VLDVGCG GIL+ A+ GA V G+DM Sbjct: 64 KKVLDVGCGGGILAESMAREGAT-VTGLDMG 93 >4KRG-A nrPDB Length = 466 Score = 34.7 bits (78), Expect = 0.071, Method: Compositional matrix adjust. Identities = 33/135 (24%), Positives = 60/135 (44%), Gaps = 7/135 (5%) Query: 36 MLQDTVRTL--SYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVD-MSSI 92 ML T + L S R I+ + +K V+D+G G G + A+ A+ V+ D + S Sbjct: 33 MLNQTAQDLEASDRADILSSLPHLTNKDVVDIGAGIGRFTTVLAE-TARWVLSTDFIESF 91 Query: 93 IEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARD 152 IE +E N I+ G + + VD++ + W+ +L +++ +L A Sbjct: 92 IEKNQER---NAHMGNISYQIGDAVHLQMDEKSVDLVFTNWLMMYLSDREVIEFLLNAMR 148 Query: 153 HYLVEGGLIFPDKCS 167 +G + + CS Sbjct: 149 WLRADGYIHLRESCS 163 >5Z9O-A nrPDB Length = 399 Score = 34.3 bits (77), Expect = 0.078, Method: Compositional matrix adjust. Identities = 16/33 (48%), Positives = 20/33 (60%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS 90 K K +LD+GCG G L + AAK V GV +S Sbjct: 165 KGKTLLDIGCGWGTLMLTAAKEYGLKVTGVTLS 197 >5WP5-A nrPDB Length = 491 Score = 34.3 bits (77), Expect = 0.079, Method: Compositional matrix adjust. Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 1/50 (2%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKE 98 + DL + VLDVGCG G + A++ HV+G+D+S ++I A E Sbjct: 274 FVAKMDLKPGQKVLDVGCGIGGGDFYMAENFDVHVVGIDLSVNMISFALE 323 >4KDC-A nrPDB Length = 246 Score = 34.3 bits (77), Expect = 0.080, Method: Compositional matrix adjust. Identities = 18/31 (58%), Positives = 21/31 (67%), Gaps = 1/31 (3%) Query: 60 KIVLDVGCGTGILSMFAAKHGAKHVIGVDMS 90 K VLDVGCG GIL+ A+ GA V G+DM Sbjct: 64 KKVLDVGCGGGILAESMAREGAT-VTGLDMG 93 >3CCF-A nrPDB Length = 279 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 17/40 (42%), Positives = 29/40 (72%), Gaps = 2/40 (5%) Query: 60 KIVLDVGCGTGILSMFAAKHGAKHVIGVD-MSSIIEMAKE 98 + +LD+GCGTG L+ A+ GA+ V+G D +++IE A++ Sbjct: 59 EFILDLGCGTGQLTEKIAQSGAE-VLGTDNAATMIEKARQ 97 >4FGZ-A nrPDB Length = 266 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 4/83 (4%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFSDK 108 I+ + +L ++ VLD+G G G M+ + H G+D+ S+I+ MA E V N +K Sbjct: 47 ILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGN---NK 103 Query: 109 ITLLRGKLEDVHLPFPKVDIIIS 131 I + P D+I S Sbjct: 104 IIFEANDILTKEFPENNFDLIYS 126 >4QNV-A nrPDB Length = 323 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 6/105 (5%) Query: 60 KIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELV-ELNGFSDKITLLRGKLED 118 + +LDVGCG+G GA +G+D + + E V +L G + LL +E Sbjct: 124 RTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIE- 182 Query: 119 VHLPFPKV-DIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 LP K D + S MG S ++ + +D + EG L+ Sbjct: 183 -QLPALKAFDTVFS--MGVLYHRRSPLEHLWQLKDQLVNEGELVL 224 >4AZW-A nrPDB Length = 471 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 54/123 (43%), Gaps = 18/123 (14%) Query: 5 AVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQ------NKDLFK 58 KD T ++L E Q F H E D R + R +I ++ L + Sbjct: 14 GTKDLNTLVSELPEIYQTIFG-------HPEWDGDAARDCNQRLDLITEQYDNLSRALGR 66 Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKELVELNG-FSDKITLLRGKL 116 VLD+GC G S+ A GA ++G+D I + + L E N F+ + + G++ Sbjct: 67 PLNVLDLGCAQGFFSLSLASKGAT-IVGIDFQQENINVCRALAEENPDFAAEFRV--GRI 123 Query: 117 EDV 119 E+V Sbjct: 124 EEV 126 >3BKX-A nrPDB Length = 275 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 42 RTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKH--GAKHVIGVDMSS 91 R ++R AI + + + +L++GCG G LS A + HV G+D++S Sbjct: 27 RQTAHRLAIAEAWQVKPGEKILEIGCGQGDLSAVLADQVGSSGHVTGIDIAS 78 >3EGE-A nrPDB Length = 261 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 7/100 (7%) Query: 32 IHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS 91 I ++ Q V + NAII +L K ++ D+G GTG S+ A G V V+ S Sbjct: 8 IGKQYSQTRVPDIRIVNAIINLLNLPKGSVIADIGAGTGGYSVALANQGL-FVYAVEPS- 65 Query: 92 IIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIIS 131 I M ++ V ++ G E++ LP VD +IS Sbjct: 66 -IVMRQQAV----VHPQVEWFTGYAENLALPDKSVDGVIS 100 >3L8D-A nrPDB Length = 242 Score = 32.3 bits (72), Expect = 0.31, Method: Compositional matrix adjust. Identities = 25/67 (37%), Positives = 36/67 (53%), Gaps = 8/67 (11%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKELVELNGFSDKITLLRGKL 116 K+ VLDVGCG G + ++ G K V GVD+S + I+ KE G ++ ++G L Sbjct: 53 KEAEVLDVGCGDGYGTYKLSRTGYKAV-GVDISEVMIQKGKE----RGEGPDLSFIKGDL 107 Query: 117 EDVHLPF 123 LPF Sbjct: 108 SS--LPF 112 >3SM3-A nrPDB Length = 235 Score = 32.3 bits (72), Expect = 0.31, Method: Compositional matrix adjust. Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 3/60 (5%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDK 108 II N L +D +LD+GCG+G +S+ A G V G+D++S I +A+ G + K Sbjct: 23 IIHNY-LQEDDEILDIGCGSGKISLELASKGYS-VTGIDINSEAIRLAETAARSPGLNQK 80 >3DMF-A nrPDB Length = 381 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 17/44 (38%), Positives = 30/44 (68%), Gaps = 3/44 (6%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGV--DMSSIIEMAKEL 99 + + VLD+G G G L++ A+ GA+ V+GV D++S++ + K L Sbjct: 233 RGRQVLDLGAGYGALTLPLARMGAE-VVGVEDDLASVLSLQKGL 275 >2AVN-A nrPDB Length = 260 Score = 32.3 bits (72), Expect = 0.34, Method: Compositional matrix adjust. Identities = 26/100 (26%), Positives = 46/100 (46%), Gaps = 9/100 (9%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHL 121 VLD+G GTG S+F + G + V +++ +KE++E+ ++ K ED+ Sbjct: 58 VLDLGGGTGKWSLFLQERGFEVV-------LVDPSKEMLEVAREKGVKNVVEAKAEDLPF 110 Query: 122 PFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLI 161 P + +++ +G L Y D LV GL+ Sbjct: 111 PSGAFEAVLA--LGDVLSYVENKDKAFSEIRRVLVPDGLL 148 >5U19-A nrPDB Length = 341 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 30/47 (63%), Gaps = 2/47 (4%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSD 107 LD+GCG+G+LS+ A + V+GVD++ + +++ LNG ++ Sbjct: 147 ALDMGCGSGVLSLVLADR-YESVLGVDVNPRAVALSRLNAALNGLTN 192 >3LPM-A nrPDB Length = 259 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 17/71 (23%), Positives = 37/71 (52%), Gaps = 3/71 (4%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKLEDVH 120 ++D+ G GI+ + + ++GV++ + +MAK V N D+I ++ L+ + Sbjct: 53 IIDLCSGNGIIPLLLSTRTKAKIVGVEIQERLADMAKRSVAYNQLEDQIEIIEYDLKKIT 112 Query: 121 --LPFPKVDII 129 +P + DI+ Sbjct: 113 DLIPKERADIV 123 >4AZV-A nrPDB Length = 569 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 54/123 (43%), Gaps = 18/123 (14%) Query: 5 AVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQ------NKDLFK 58 KD T ++L E Q F H E D R + R +I ++ L + Sbjct: 14 GTKDLNTLVSELPEIYQTIFG-------HPEWDGDAARDCNQRLDLITEQYDNLSRALGR 66 Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKELVELNG-FSDKITLLRGKL 116 VLD+GC G S+ A GA ++G+D I + + L E N F+ + + G++ Sbjct: 67 PLNVLDLGCAQGFFSLSLASKGAT-IVGIDFQQENINVCRALAEENPDFAAEFRV--GRI 123 Query: 117 EDV 119 E+V Sbjct: 124 EEV 126 >6BQC-A nrPDB Length = 383 Score = 31.6 bits (70), Expect = 0.57, Method: Compositional matrix adjust. Identities = 17/41 (41%), Positives = 26/41 (63%), Gaps = 1/41 (2%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIE-MAKELVE 101 VLD+GCG G L+ + A + V+GV +S+ + MA+E E Sbjct: 172 VLDIGCGWGGLAHYMASNYDVSVVGVTISAEQQKMAQERCE 212 >4QPN-A nrPDB Length = 227 Score = 31.2 bits (69), Expect = 0.61, Method: Compositional matrix adjust. Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Query: 52 QNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELN 103 QN D F+ K V+++G GTGI+ + AA G I D+ +E + V+ N Sbjct: 71 QNVD-FRGKKVIELGAGTGIVGILAALQGGDVTI-TDLPLALEQIQGNVQAN 120 >3DLC-A nrPDB Length = 219 Score = 30.8 bits (68), Expect = 0.82, Method: Compositional matrix adjust. Identities = 19/76 (25%), Positives = 40/76 (52%), Gaps = 1/76 (1%) Query: 63 LDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKLEDVHL 121 +D+G G G LS+ AK + +D S + E+A + + +D+I +++G + ++ + Sbjct: 48 IDIGSGPGALSIALAKQSDFSIRALDFSKHMNEIALKNIADANLNDRIQIVQGDVHNIPI 107 Query: 122 PFPKVDIIISEWMGYF 137 D+I+S +F Sbjct: 108 EDNYADLIVSRGSVFF 123 >3HA5-A nrPDB Length = 318 Score = 30.8 bits (68), Expect = 0.98, Method: Compositional matrix adjust. Identities = 40/150 (26%), Positives = 63/150 (42%), Gaps = 28/150 (18%) Query: 1 MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRT----------LSYRNAI 50 M++ + + T +T+ + + HY S D + + QD RT L+ A Sbjct: 21 MAEKPISPTKT-RTRFEDIQAHYDVSDDFFA----LFQDPTRTYSCAYFEPPELTLEEAQ 75 Query: 51 IQNKDLFKDKI-------VLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKE--LVE 101 DL DK+ +LD+GCG G A + +VIG+ +S E L Sbjct: 76 YAKVDLNLDKLDLKPGMTLLDIGCGWGTTMRRAVERFDVNVIGLTLSKNQHARCEQVLAS 135 Query: 102 LNGFSDKITLLRGKLEDVHLPFPKVDIIIS 131 ++ + LL+G ED P VD I+S Sbjct: 136 IDTNRSRQVLLQG-WEDFAEP---VDRIVS 161 >1DUS-A nrPDB Length = 194 Score = 30.8 bits (68), Expect = 0.99, Method: Compositional matrix adjust. Identities = 16/58 (27%), Positives = 31/58 (53%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSD 107 +++N + KD +LD+GCG G++ + A + I++AKE ++LN + Sbjct: 44 LVENVVVDKDDDILDLGCGYGVIGIALADEVKSTTMADINRRAIKLAKENIKLNNLDN 101 >2H1R-A nrPDB Length = 299 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 5/72 (6%) Query: 61 IVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFSDKITLLRGKLEDV 119 IVL++GCGTG L++ AK VI +D+ S +I K+ G+++ + + G + + Sbjct: 45 IVLEIGCGTGNLTV-KLLPLAKKVITIDIDSRMISEVKKRCLYEGYNN-LEVYEG--DAI 100 Query: 120 HLPFPKVDIIIS 131 FPK D+ + Sbjct: 101 KTVFPKFDVCTA 112 >3JWI-A nrPDB Length = 207 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 37/63 (58%), Gaps = 6/63 (9%) Query: 60 KIVLDVGCGTGILSMFAAKHGA-KHVIGVDMS-SIIEMAKELVELNGFSD----KITLLR 113 K V+D+GCG G L K + + + GVD+S S++E AK+ ++++ + +I+L + Sbjct: 29 KKVIDLGCGEGNLLSLLLKDKSFEQITGVDVSYSVLERAKDRLKIDRLPEMQRKRISLFQ 88 Query: 114 GKL 116 L Sbjct: 89 SSL 91 >6J2X-P nrPDB Length = 445 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 33/56 (58%), Gaps = 2/56 (3%) Query: 205 PIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDI 260 P +D++ +N+ N+ D+L+ + T + SDLA S+ ++ AK D++ W D+ Sbjct: 22 PKIDSLAQNDCNSALDQLLVLEKKTRQASDLA--SSKEVLAKIVDLLASRNKWDDL 75 >3G5T-A nrPDB Length = 299 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 13/44 (29%), Positives = 27/44 (61%), Gaps = 2/44 (4%) Query: 60 KIVLDVGCGTGILSMFAAKH--GAKHVIGVDMSSIIEMAKELVE 101 K+++DVGCG G ++ A+ + +IG D+S+ + E+++ Sbjct: 38 KLLVDVGCGPGTATLQMAQELKPFEQIIGSDLSATMIKTAEVIK 81 >4JIJ-A nrPDB Length = 164 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 20/44 (45%) Query: 51 IQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIE 94 IQ F D + +G G G A H H +G+D SS+ E Sbjct: 93 IQGDAHFDDDELWSLGKGVGYSLFLVAAHAFGHALGLDHSSVPE 136 >1NKV-A nrPDB Length = 256 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 3/50 (6%) Query: 62 VLDVGCGTG-ILSMFAAKHGAKHVIGVDMSSII-EMAKELVELNGFSDKI 109 +LD+G G+G +L +A HG G+DMSS+ AK E G S+++ Sbjct: 40 ILDLGSGSGEMLCTWARDHGITGT-GIDMSSLFTAQAKRRAEELGVSERV 88 >2VS1-A nrPDB Length = 425 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 22/65 (33%), Positives = 37/65 (56%), Gaps = 4/65 (6%) Query: 42 RTLSYR--NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKE 98 +T SY+ N + + +L + + +LD+ G G ++ AK G +V G D + IEMA+ Sbjct: 272 QTNSYQAVNLVRKVSELVEGEKILDMYSGVGTFGIYLAKRGF-NVKGFDSNEFAIEMARR 330 Query: 99 LVELN 103 VE+N Sbjct: 331 NVEIN 335 >1ZQ9-A nrPDB Length = 285 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 26/95 (27%), Positives = 47/95 (49%), Gaps = 8/95 (8%) Query: 31 GIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS 90 GI + +L++ + N+II L +VL+VG GTG +++ AK V+ ++ Sbjct: 5 GIGQHILKNPLII----NSIIDKAALRPTDVVLEVGPGTGNMTV-KLLEKAKKVVACELD 59 Query: 91 S--IIEMAKELVELNGFSDKITLLRGKLEDVHLPF 123 + E+ K V+ + K+ +L G + LPF Sbjct: 60 PRLVAELHKR-VQGTPVASKLQVLVGDVLKTDLPF 93 >5W0T-A nrPDB Length = 304 Score = 28.9 bits (63), Expect = 3.3, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 31/67 (46%), Gaps = 2/67 (2%) Query: 66 GCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPK 125 GCG +L+ AK + I + MSSI M K E N D + L KL+ + + Sbjct: 87 GCGKTMLAKALAKESGANFISIRMSSI--MDKWYGESNKIVDAMFSLANKLQPCIIFIDE 144 Query: 126 VDIIISE 132 +D + E Sbjct: 145 IDSFLRE 151 >3GK7-A nrPDB Length = 448 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 6/81 (7%) Query: 29 HYGIHEEMLQDTVRTLSYRNAII--QNKDLFKDKIVLDVGCGTGILSMFAA---KHGAKH 83 H GIH EM+ D V L Y +I K + K K+ + GT L FAA K K Sbjct: 232 HLGIHSEMISDGVVDL-YEAGVIDCSQKSIDKGKMAITFLMGTKRLYDFAANNPKVELKP 290 Query: 84 VIGVDMSSIIEMAKELVELNG 104 V ++ S++ ++V +N Sbjct: 291 VDYINHPSVVAQCSKMVCINA 311 >4MTL-A nrPDB Length = 244 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 12/37 (32%), Positives = 24/37 (64%), Gaps = 1/37 (2%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSII 93 F+D +L++G G G++S+ A+ GA+ V D+ ++ Sbjct: 91 FQDAKILEIGAGPGLVSIVASILGAQ-VTATDLPDVL 126 >5XJ2-A nrPDB Length = 454 Score = 28.5 bits (62), Expect = 3.9, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 10/81 (12%) Query: 30 YGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM 89 Y ++ EM + +T I +L KD +++D G G + + AKH K V GV++ Sbjct: 282 YQVNTEMAEKLYQTA------IDFAELKKDDVIIDAYSGIGTIGLSVAKH-VKEVYGVEL 334 Query: 90 SSIIEMAKELVELNGFSDKIT 110 I A E + N +KIT Sbjct: 335 ---IPEAVENSQKNASLNKIT 352 >1UWV-A nrPDB Length = 433 Score = 28.5 bits (62), Expect = 4.1, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 35/65 (53%), Gaps = 3/65 (4%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVD-MSSIIEMAKELVELNGFSDKITLLR 113 D+ + VLD+ CG G ++ A A V+GV+ + +++E ++ LNG + +T Sbjct: 283 DVQPEDRVLDLFCGMGNFTLPLATQAAS-VVGVEGVPALVEKGQQNARLNGLQN-VTFYH 340 Query: 114 GKLED 118 LE+ Sbjct: 341 ENLEE 345 >1RI1-A nrPDB Length = 298 Score = 28.1 bits (61), Expect = 5.4, Method: Compositional matrix adjust. Identities = 27/93 (29%), Positives = 38/93 (40%), Gaps = 5/93 (5%) Query: 3 KTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRN---AIIQNKDLFKD 59 KT KD A E K E +HY NS G T+ + N A + + Sbjct: 8 KTFRKDQAMEGKK-EEIREHY-NSIRERGRESRQRSKTINIRNANNFIKACLIRLYTKRG 65 Query: 60 KIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI 92 VLD+GCG G + + G GVD++ + Sbjct: 66 DSVLDLGCGKGGDLLKYERAGIGEYYGVDIAEV 98 >2ZLB-A nrPDB Length = 223 Score = 28.1 bits (61), Expect = 5.8, Method: Compositional matrix adjust. Identities = 25/118 (21%), Positives = 52/118 (44%), Gaps = 15/118 (12%) Query: 57 FKDKIVLDVG--CGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLR 113 + +VL++G CG + M ++ ++M+ + ++++ G DK+T+L Sbjct: 59 YSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILN 118 Query: 114 GKLEDVHLPFPK---VD----IIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPD 164 G +D+ K VD + + W +L DT+L + L +G ++ D Sbjct: 119 GASQDLIPQLKKKYDVDTLDMVFLDHWKDRYL-----PDTLLLEKCGLLRKGTVLLAD 171 >6MRO-A nrPDB Length = 194 Score = 28.1 bits (61), Expect = 6.3, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 27/43 (62%), Gaps = 2/43 (4%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS 90 A+I++ ++ + LD+GCG G ++ AK+G V G+D++ Sbjct: 23 QALIESGEIRPGR-ALDIGCGRGENAIMLAKNGCD-VTGIDLA 63 >6G4W-q nrPDB Length = 281 Score = 27.7 bits (60), Expect = 6.9, Method: Compositional matrix adjust. Identities = 11/32 (34%), Positives = 21/32 (65%), Gaps = 1/32 (3%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMSSII 93 +LD+GCGTG+ + + G + +G+D+S + Sbjct: 57 LLDIGCGTGLSGSYLSDEG-HYWVGLDISPAM 87 >3V8V-A nrPDB Length = 702 Score = 27.7 bits (60), Expect = 7.4, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 1/71 (1%) Query: 39 DTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAK 97 DT L +R A + K K L++ TG ++ A GA+ VDMS + +E A+ Sbjct: 519 DTGLFLDHRIARRMLGQMSKGKDFLNLFSYTGSATVHAGLGGARSTTTVDMSRTYLEWAE 578 Query: 98 ELVELNGFSDK 108 + LNG + + Sbjct: 579 RNLRLNGLTGR 589 >4LEC-A nrPDB Length = 212 Score = 27.7 bits (60), Expect = 8.6, Method: Compositional matrix adjust. Identities = 15/47 (31%), Positives = 25/47 (53%), Gaps = 1/47 (2%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELN 103 + + +++G GTG++ + AA GA HV D +E K V+ N Sbjct: 58 LRGRSAVELGAGTGLVGIVAALLGA-HVTITDRKVALEFLKSNVQAN 103 >3MGG-A nrPDB Length = 276 Score = 27.7 bits (60), Expect = 8.7, Method: Compositional matrix adjust. Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 5/64 (7%) Query: 62 VLDVGCGTGILSMFAAKHGA-KHVIGVDMS-SIIEMAKELVELNGFSDKITLLRGKLEDV 119 VL+ GCG G ++ AK+ + +D+S +E A+E E NG + + L+ + Sbjct: 41 VLEAGCGIGAQTVILAKNNPDAEITSIDISPESLEKARENTEKNGIKN-VKFLQANI--F 97 Query: 120 HLPF 123 LPF Sbjct: 98 SLPF 101 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1G6Q-1 nrPDB 486 e-138 3Q7E-A nrPDB 407 e-114 5DST-A nrPDB 405 e-113 4RYL-A nrPDB 392 e-109 1F3L-A nrPDB 386 e-108 6CU3-A nrPDB 384 e-107 5EGS-A nrPDB 369 e-102 5JMQ-A nrPDB 369 e-102 5LV5-A nrPDB 364 e-101 5FUB-A nrPDB 358 2e-99 3B3J-A nrPDB 345 1e-95 5IS8-A nrPDB 344 2e-95 4IKP-A nrPDB 328 3e-90 3R0Q-C nrPDB 304 3e-83 4LWO-B nrPDB 263 8e-71 3X0D-A nrPDB 218 2e-57 5EKU-A nrPDB 208 3e-54 6OGN-A nrPDB 206 9e-54 4M36-A nrPDB 206 1e-53 4G56-A nrPDB 187 5e-48 3SVZ-A nrPDB 144 7e-35 3BKW-A nrPDB 111 7e-25 2AS0-A nrPDB 102 2e-22 5JE5-A nrPDB 93 2e-19 Sequences not found previously or not previously below threshold: 5FA5-A nrPDB 164 4e-41 3UA4-A nrPDB 76 2e-14 5WP4-A nrPDB 64 1e-10 5WP5-A nrPDB 59 3e-09 1L3B-A nrPDB 57 1e-08 1WXW-A nrPDB 56 2e-08 3D2L-A nrPDB 55 5e-08 3MGG-A nrPDB 54 1e-07 3DLC-A nrPDB 54 1e-07 3CJR-A nrPDB 54 1e-07 4P7C-A nrPDB 52 3e-07 3BUS-A nrPDB 52 4e-07 4PNE-A nrPDB 52 5e-07 3A27-A nrPDB 52 5e-07 4FGZ-A nrPDB 51 5e-07 1I9G-A nrPDB 51 8e-07 2AVN-A nrPDB 51 1e-06 5Z9O-A nrPDB 51 1e-06 2ZZN-A nrPDB 49 4e-06 3LPM-A nrPDB 49 4e-06 5GM1-A nrPDB 48 5e-06 3C0K-A nrPDB 48 5e-06 1DUS-A nrPDB 48 6e-06 3A26-A nrPDB 47 9e-06 4IV8-A nrPDB 47 1e-05 6BQC-A nrPDB 47 1e-05 4KDR-A nrPDB 47 1e-05 1WY7-A nrPDB 47 1e-05 2P8J-A nrPDB 47 1e-05 4KRI-A nrPDB 47 1e-05 4KDC-A nrPDB 46 2e-05 1JG3-A nrPDB 46 2e-05 3EGE-A nrPDB 46 3e-05 1VQ1-A nrPDB 46 3e-05 2O57-A nrPDB 46 3e-05 1RI1-A nrPDB 46 4e-05 4KRG-A nrPDB 45 4e-05 3L8D-A nrPDB 45 5e-05 4MWZ-A nrPDB 44 7e-05 6MRO-A nrPDB 44 8e-05 1UWV-A nrPDB 44 9e-05 1NKV-A nrPDB 43 2e-04 4NEC-A nrPDB 43 2e-04 5H02-A nrPDB 43 2e-04 3V8V-A nrPDB 43 2e-04 3DMF-A nrPDB 42 3e-04 2YXD-A nrPDB 42 3e-04 5FAD-A nrPDB 42 3e-04 2PJD-A nrPDB 42 3e-04 5BXY-A nrPDB 42 3e-04 6GKZ-A nrPDB 42 4e-04 4INE-A nrPDB 42 4e-04 4FS8-A nrPDB 42 4e-04 2VS1-A nrPDB 42 4e-04 3CCF-A nrPDB 42 4e-04 5BP7-A nrPDB 42 5e-04 3SM3-A nrPDB 42 5e-04 2GLU-A nrPDB 42 5e-04 3LGA-A nrPDB 41 7e-04 2ESR-A nrPDB 41 7e-04 2R3S-A nrPDB 41 8e-04 3GU3-A nrPDB 41 0.001 5YAC-A nrPDB 41 0.001 4LG1-A nrPDB 40 0.001 5U19-A nrPDB 40 0.001 4QPN-A nrPDB 40 0.002 1XDU-A nrPDB 40 0.002 4O29-A nrPDB 40 0.002 4AZW-A nrPDB 40 0.002 3GDH-A nrPDB 39 0.002 3EGI-A nrPDB 39 0.002 4AZV-A nrPDB 39 0.002 4HTF-A nrPDB 39 0.002 5EVJ-A nrPDB 39 0.002 5I2H-A nrPDB 39 0.003 3BKX-A nrPDB 39 0.003 2IFT-A nrPDB 39 0.003 3GRV-A nrPDB 39 0.003 3FYD-A nrPDB 39 0.003 4F86-A nrPDB 39 0.003 2I6G-A nrPDB 39 0.003 5HJK-A nrPDB 39 0.004 3TMA-A nrPDB 38 0.006 2XVM-A nrPDB 38 0.006 4QDJ-A nrPDB 37 0.009 3VC2-A nrPDB 37 0.011 1R74-A nrPDB 37 0.012 2OXT-A nrPDB 37 0.012 2H1R-A nrPDB 37 0.013 1KP9-A nrPDB 37 0.013 1O54-A nrPDB 37 0.013 5KPG-A nrPDB 37 0.013 2QQH-A nrPDB 37 0.014 1XCL-A nrPDB 37 0.015 4QNV-A nrPDB 37 0.016 3ELU-A nrPDB 37 0.016 5M58-A nrPDB 37 0.017 3OJY-A nrPDB 36 0.024 6DCC-A nrPDB 36 0.026 2RD7-A nrPDB 36 0.026 1D2C-A nrPDB 36 0.028 5MGZ-A nrPDB 36 0.029 1ZQ9-A nrPDB 36 0.029 3I9F-A nrPDB 36 0.033 6C5B-A nrPDB 36 0.034 6M83-A nrPDB 36 0.037 1VBF-A nrPDB 36 0.038 5BP9-A nrPDB 35 0.042 3P9N-A nrPDB 35 0.044 1KR5-A nrPDB 35 0.048 1TPY-A nrPDB 35 0.052 6AW7-A nrPDB 35 0.054 1XTP-A nrPDB 35 0.054 5F8E-A nrPDB 34 0.068 1MJF-A nrPDB 34 0.076 2B25-A nrPDB 34 0.078 1Y8C-A nrPDB 34 0.080 1P91-A nrPDB 34 0.081 5XJ2-A nrPDB 34 0.082 1P1B-A nrPDB 34 0.085 2FHP-A nrPDB 34 0.086 2YXE-A nrPDB 34 0.11 5Z7M-A nrPDB 34 0.12 3HEM-A nrPDB 34 0.14 4LEC-A nrPDB 34 0.14 2YVL-A nrPDB 33 0.15 3M70-A nrPDB 33 0.17 6F5Z-A nrPDB 33 0.19 3HP7-A nrPDB 33 0.19 4MTL-A nrPDB 33 0.20 4G1P-A nrPDB 33 0.20 3C3P-A nrPDB 33 0.21 5EHG-A nrPDB 33 0.23 3OPN-A nrPDB 33 0.23 4DZR-A nrPDB 33 0.24 3G5T-A nrPDB 32 0.27 4UEJ-A nrPDB 32 0.29 3E23-A nrPDB 32 0.29 1R18-A nrPDB 32 0.32 2PWY-A nrPDB 32 0.36 2PLW-A nrPDB 32 0.37 3TFW-A nrPDB 32 0.37 4HG2-A nrPDB 32 0.40 3NDI-A nrPDB 32 0.41 4V0R-A nrPDB 32 0.42 5IKM-A nrPDB 32 0.51 3TR6-A nrPDB 32 0.51 5ZL9-A nrPDB 31 0.62 4DCM-A nrPDB 31 0.63 6GFK-A nrPDB 31 0.64 6DU5-A nrPDB 31 0.64 6G4W-q nrPDB 31 0.76 1RQX-A nrPDB 31 0.77 3O4F-A nrPDB 31 0.77 3NJR-A nrPDB 31 0.77 3LST-A nrPDB 31 0.78 3R9X-B nrPDB 31 0.79 2ZIG-A nrPDB 31 0.96 2ZFU-A nrPDB 31 1.0 3BXO-A nrPDB 31 1.1 3EVC-A nrPDB 31 1.1 3G7U-A nrPDB 31 1.2 4DMG-A nrPDB 30 1.3 2VDV-E nrPDB 30 1.4 3UFB-A nrPDB 30 1.4 5JWY-A nrPDB 30 1.4 5UBB-A nrPDB 30 1.5 3GCZ-A nrPDB 30 1.6 2ZLB-A nrPDB 30 1.7 3JWJ-A nrPDB 30 1.8 4TS7-A nrPDB 30 1.8 5CVU-A nrPDB 30 1.9 2B3T-A nrPDB 30 1.9 1ECF-A nrPDB 30 2.0 5N5D-A nrPDB 30 2.1 2RBB-A nrPDB 29 2.3 5GQB-A nrPDB 29 2.3 2PXA-A nrPDB 29 2.8 4PEM-A nrPDB 29 3.0 4PEL-A nrPDB 29 3.0 5EOV-A nrPDB 29 3.3 5X7F-A nrPDB 29 4.4 5DF0-A nrPDB 28 4.9 5WMM-A nrPDB 28 5.1 3PT9-A nrPDB 28 5.5 >1G6Q-1 nrPDB Length = 328 Score = 486 bits (1251), Expect = e-138, Method: Composition-based stats. Identities = 325/328 (99%), Positives = 327/328 (99%) Query: 21 QHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG 80 +YF+SYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG Sbjct: 1 DYYFDSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG 60 Query: 81 AKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLY 140 AKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLY Sbjct: 61 AKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLY 120 Query: 141 ESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPL 200 ESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPL Sbjct: 121 ESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPL 180 Query: 201 VLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDI 260 VLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDI Sbjct: 181 VLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDI 240 Query: 261 VFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLN 320 VFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLN Sbjct: 241 VFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLN 300 Query: 321 IKISYKFESNGIDGNSRSRKNEGSYLMH 348 IKISYKFESNGIDGNSRSRKNEGSYLMH Sbjct: 301 IKISYKFESNGIDGNSRSRKNEGSYLMH 328 >3Q7E-A nrPDB Length = 349 Score = 407 bits (1046), Expect = e-114, Method: Composition-based stats. Identities = 159/323 (49%), Positives = 224/323 (69%), Gaps = 4/323 (1%) Query: 10 ATEKT--KLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGC 67 ++EK + S+ +YF+SY H+GIHEE+L+D VRTL+YRN++ N+ LFKDK+VLDVG Sbjct: 16 SSEKPNAEDMTSKDYYFDSYAHFGIHEELLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGS 75 Query: 68 GTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVD 127 GTGIL MFAAK GA+ VIG++ SSI + A ++V+ N +T+++GK+E+V LP KVD Sbjct: 76 GTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVD 135 Query: 128 IIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQ 187 IIISEWMGY L YESM++TVL+ARD +L GLIFPD+ ++++ +ED QYKD K+++W+ Sbjct: 136 IIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWE 195 Query: 188 DVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKR 247 +VYGFD S + + EP+VD V+ + T + + E D+ TVK+ DL F S F L KR Sbjct: 196 NVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKR 255 Query: 248 QDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGEL 307 D ++ +V +F+I F + + FST P +PYTHWKQT+FY D L +TG+ I G + Sbjct: 256 NDYVHALVAYFNIEF--TRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTI 313 Query: 308 VCSPNEKNNRDLNIKISYKFESN 330 PN KNNRDL+ I F+ Sbjct: 314 GMRPNAKNNRDLDFTIDLDFKGQ 336 >5DST-A nrPDB Length = 332 Score = 405 bits (1040), Expect = e-113, Method: Composition-based stats. Identities = 155/317 (48%), Positives = 221/317 (69%), Gaps = 2/317 (0%) Query: 14 TKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILS 73 ++ S +YF+SY H+GIHEEML+D VRTL+YRN++ NK +FKDK+VLDVG GTGILS Sbjct: 5 SEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILS 64 Query: 74 MFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEW 133 MFAAK GAK V G++ SSI + ++++++ N + IT+ +GK+E+V LP KVDIIISEW Sbjct: 65 MFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEW 124 Query: 134 MGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFD 193 MGY L YESM++TV++ARD +L GGL+FPD+ ++++ +ED QYKD K+++W++VYGFD Sbjct: 125 MGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFD 184 Query: 194 YSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMING 253 + + + EP+VD V+ V T + + E D+ TVK +L+F S F L +R D ++ Sbjct: 185 MTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHA 244 Query: 254 IVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNE 313 +VT+F+I F K + + FST P APYTHWKQT+FY D L G+ I G + PN Sbjct: 245 LVTYFNIEF--TKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNA 302 Query: 314 KNNRDLNIKISYKFESN 330 KN RDL+ + F+ Sbjct: 303 KNVRDLDFTVDLDFKGQ 319 >4RYL-A nrPDB Length = 340 Score = 392 bits (1007), Expect = e-109, Method: Composition-based stats. Identities = 145/311 (46%), Positives = 201/311 (64%), Gaps = 1/311 (0%) Query: 16 LSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMF 75 + + YF+SY HYGIHEEML+D +RT SYR+ I QN +FKDK+VLDVGCGTGILSMF Sbjct: 22 QEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMF 81 Query: 76 AAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMG 135 AAK GAK V+GVD S I+ A +++ LN D ITL++GK+E+VHLP KVD+IISEWMG Sbjct: 82 AAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMG 141 Query: 136 YFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYS 195 YFLL+ESM+D+VLYA++ YL +GG ++PD C+I L + D +++ +W DVYGF S Sbjct: 142 YFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMS 201 Query: 196 PFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIV 255 V+ E +V+ ++ + + + D +T ISDL F S+F L R M I Sbjct: 202 CMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIA 261 Query: 256 TWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKN 315 +FDI F R V FSTGP + THWKQT+F + G+ ++G++ N+K+ Sbjct: 262 GYFDIYFEKNCHNRVV-FSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKD 320 Query: 316 NRDLNIKISYK 326 R L + ++ Sbjct: 321 PRSLTVTLTLN 331 >1F3L-A nrPDB Length = 321 Score = 386 bits (991), Expect = e-108, Method: Composition-based stats. Identities = 144/315 (45%), Positives = 199/315 (63%), Gaps = 1/315 (0%) Query: 16 LSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMF 75 + + YF+SY HYGIHEEML+D VRT SYR+ I QN +FKDK+VLDVGCGTGILSMF Sbjct: 3 QEDEDGVYFSSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMF 62 Query: 76 AAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMG 135 AAK GAK VI VD S I+ A +++ LN D I L++GK+E+V LP KVD+IISEWMG Sbjct: 63 AAKAGAKKVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLPVEKVDVIISEWMG 122 Query: 136 YFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYS 195 YFLL+ESM+D+VLYA+ YL +GG ++PD C+I L + D +++ +W DVYGF+ S Sbjct: 123 YFLLFESMLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMS 182 Query: 196 PFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIV 255 V+ E +V+ V+ + + + D +T ISDL F S+F L + M + Sbjct: 183 CMKKAVIPEAVVEVVDHKTLISDPCDIKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVA 242 Query: 256 TWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKN 315 +FDI F R V FSTGP + THWKQTIF + G+ ++G++ N+K+ Sbjct: 243 GYFDIYFEKNCHNRVV-FSTGPQSTKTHWKQTIFLLEKPFPVKAGEALKGKITVHKNKKD 301 Query: 316 NRDLNIKISYKFESN 330 R L + ++ + Sbjct: 302 PRSLIVTLTLNSSTQ 316 >6CU3-A nrPDB Length = 336 Score = 384 bits (985), Expect = e-107, Method: Composition-based stats. Identities = 160/306 (52%), Positives = 215/306 (70%), Gaps = 5/306 (1%) Query: 31 GIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS 90 GIHEEML+D +RT +Y+NAI+QNK LFKDK+VLD+GCGTGIL +FAAK GAK VIG+DMS Sbjct: 24 GIHEEMLKDGIRTNAYKNAILQNKHLFKDKVVLDIGCGTGILCLFAAKAGAKRVIGIDMS 83 Query: 91 SIIEMAKELVELNGFSDKITLLRGKLED---VHLPFPKVDIIISEWMGYFLLYESMMDTV 147 II+ A+++V NG+S I L++GK+ED + KVDIIISEWMGYFLLYESM+ TV Sbjct: 84 DIIDKARQIVSDNGYSHVIELIKGKVEDIAQLPFGIEKVDIIISEWMGYFLLYESMLQTV 143 Query: 148 LYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIV 207 L ARD +L GG +FPDKC++++ G+EDS+YK +K+++W +VYGF++S L EP+V Sbjct: 144 LSARDRWLRPGGYLFPDKCTMYICGIEDSEYKRDKIDFWDNVYGFNFSAIKADALREPLV 203 Query: 208 DTVERNNVNTTSDKLIEFDLNTVKISDL-AFKSNFKLTAKRQDMINGIVTWFDIVFPAPK 266 D VE + TT K +E DLNT++ DL ++F+ T++ Q+ V WFD VF Sbjct: 204 DFVESQQIITTQSKFLEIDLNTIQPEDLKQITTSFEFTSQYQEYCQAFVAWFDCVFSRGP 263 Query: 267 GKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYK 326 K PVEFSTGP THWKQT+FY +DL + D I+G + S N+ N+RDL+I + Y Sbjct: 264 HK-PVEFSTGPFTEGTHWKQTVFYLENDLPLKPNDVIKGTITISQNKSNHRDLDISMKYT 322 Query: 327 FESNGI 332 + Sbjct: 323 VNGGAV 328 >5EGS-A nrPDB Length = 376 Score = 369 bits (947), Expect = e-102, Method: Composition-based stats. Identities = 113/339 (33%), Positives = 179/339 (52%), Gaps = 16/339 (4%) Query: 7 KDSATEKTKLS--ESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLD 64 +++A E+ + + E +Q Y+ Y +HEEM+ D VRT +YR I++N + K VLD Sbjct: 30 REAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLD 89 Query: 65 VGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFP 124 VG GTGILS+F A+ GA+ V V+ S+I + A+E+V NG D++ +L G +E V LP Sbjct: 90 VGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELP-E 148 Query: 125 KVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLN 184 +VD I+SEWMGY LL+ESM+ +VL+AR +L EGGL+ P + + + D Q + +L Sbjct: 149 QVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISD-QMLEWRLG 207 Query: 185 YWQDV---YGFDYSPFVPLVLH------EPIVDTVERNNVNTTSDKLIEFDLNTVKIS-- 233 +W V YG D S E +V + +V + + +L+ + Sbjct: 208 FWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQE 267 Query: 234 -DLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFP 292 + F+ + ++G WF + FP + ++P+ ST P P THWKQ + Y Sbjct: 268 LEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLN 327 Query: 293 DDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNG 331 + + E + GE+ P+ N R L + + YK Sbjct: 328 EPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQE 366 >5JMQ-A nrPDB Length = 446 Score = 369 bits (946), Expect = e-102, Method: Composition-based stats. Identities = 114/332 (34%), Positives = 186/332 (56%), Gaps = 10/332 (3%) Query: 14 TKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILS 73 + + ++ YF+SY +H EML D RT Y + I+QNK+ KDK++LDVGCGTGI+S Sbjct: 106 PEDTWQDEEYFDSYGTLKLHLEMLADQPRTTKYHSVILQNKESLKDKVILDVGCGTGIIS 165 Query: 74 MFAAKHG-AKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISE 132 +F A H K V V+ S + + +LV NGF+D IT+ + K+EDV LP KVD+++SE Sbjct: 166 LFCAHHARPKAVYAVEASDMAQHTSQLVLQNGFADTITVFQQKVEDVVLP-EKVDVLVSE 224 Query: 133 WMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGF 192 WMG LL+E M++++LYARD +L G+I+P ++HL + K+ +W + Y F Sbjct: 225 WMGTCLLFEFMIESILYARDTWLKGDGIIWPTTAALHLVPCSAEKDYHSKVLFWDNAYEF 284 Query: 193 DYSPFVPLVLHEPIVDT-----VERNNVNTTSDKLIEFDLNTVKISDLA-FKSNFKLTAK 246 + S L + E ++ + + +++ D+ TV++ DL + + + Sbjct: 285 NLSALKSLAIKEFFSRPKSNHILKPEDCLSEPCTILQLDMRTVQVPDLETMRGELRFDIQ 344 Query: 247 RQDMINGIVTWFDIVFPAPKGKRPVE-FSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEG 305 + ++G WF + F + + +P + STGP P THWKQT+F D + TGD + G Sbjct: 345 KAGTLHGFTAWFSVYFQSLEEGQPQQVLSTGPLHPTTHWKQTLFMMDDPVPVHTGDVVTG 404 Query: 306 ELVCSPNEKNNRDLNIKISYKFESNGIDGNSR 337 +V N R +++ +S+ S +D S+ Sbjct: 405 SVVLQRNPVWRRHMSVSLSWVVTS-ALDPTSQ 435 >5LV5-A nrPDB Length = 403 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 116/327 (35%), Positives = 173/327 (52%), Gaps = 14/327 (4%) Query: 13 KTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGIL 72 + SE +Q Y+ Y +HEEM+ D VRT +YR I++N + K VLDVG GTGIL Sbjct: 65 RRTKSERDQLYYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGIL 124 Query: 73 SMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISE 132 S+F A+ GA+ V V+ S+I + A+E+V LNG D++ +L G +E V LP +VD I+SE Sbjct: 125 SIFCAQAGARRVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVELP-ERVDAIVSE 183 Query: 133 WMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDV--- 189 WMGY LL+ESM+ +VL+AR +L EGGL+ P + +A + D Q + +L +W V Sbjct: 184 WMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISD-QMLEWRLGFWSQVKQH 242 Query: 190 YGFDYSPFVPLVLH------EPIVDTVERNNVNTTSDKLIEFDLNTVKIS---DLAFKSN 240 YG D S E +V + +V + + +L + + Sbjct: 243 YGVDMSCMESFATRCLMGHSEIVVQDLSGEDVLARPQRFAQLELARAGLEQELEAGVGGR 302 Query: 241 FKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETG 300 F+ + ++G WF + FP ++P+ ST P P THWKQ + Y + + E Sbjct: 303 FRCSCYGSAPLHGFAVWFQVTFPGGDSEKPLVLSTSPLHPATHWKQALLYLNEPVPVEQD 362 Query: 301 DTIEGELVCSPNEKNNRDLNIKISYKF 327 I GE+ P+ N R L I + YK Sbjct: 363 TDISGEITLLPSPDNPRRLRILLRYKV 389 >5FUB-A nrPDB Length = 337 Score = 358 bits (919), Expect = 2e-99, Method: Composition-based stats. Identities = 105/322 (32%), Positives = 173/322 (53%), Gaps = 9/322 (2%) Query: 19 SEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAK 78 + YF +Y +H EML D RT +YR I+ N ++K+VLD+GCGTG++S+F A Sbjct: 5 QDDEYFGNYGTLRLHLEMLSDKPRTETYRQVILSNSAALREKVVLDLGCGTGVISLFCAL 64 Query: 79 HG-AKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYF 137 V V+ SS+ E +ELV+ NG +T+ + + E++ LP KVD+++SEWMG Sbjct: 65 LAKPAGVYAVEASSMAEHTEELVKQNGCDGVVTVFQERAENLTLP-TKVDVLVSEWMGNC 123 Query: 138 LLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPF 197 LL+E M+++VL ARD +L +GG+++P + + + +K+ +W++ YG ++S Sbjct: 124 LLFEYMLESVLLARDRWLKKGGMMWPSSACLTIVPCQAFSDYRQKVEFWENPYGLNFSYL 183 Query: 198 VPLVLHEPIVDT-----VERNNVNTTSDKLIEFDLNTVKISDLA-FKSNFKLTAKRQDMI 251 L E + ++ + +T +I D+ T+++SDL K F T ++ M Sbjct: 184 QSLAQKEFLSKPKFSHHLQPEDCLSTPADVITLDMVTIQVSDLERLKGEFTFTVEKSGMF 243 Query: 252 NGIVTWFDIVFPAPKGKRP-VEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCS 310 +G WF F + P +E +TGP++ THWKQT+F + E GD I G + Sbjct: 244 HGFTVWFSAHFQCLEEDGPSIELNTGPYSEITHWKQTLFMLDAPVSVEEGDIIAGSIRLQ 303 Query: 311 PNEKNNRDLNIKISYKFESNGI 332 N R L+I + S + Sbjct: 304 RNPIWRRHLSITFLWNINSTEV 325 >3B3J-A nrPDB Length = 480 Score = 345 bits (886), Expect = 1e-95, Method: Composition-based stats. Identities = 123/345 (35%), Positives = 181/345 (52%), Gaps = 28/345 (8%) Query: 2 SKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKI 61 T + +E+T+ S + Q YF Y + + M+QD VRT +Y+ AI+QN FKDKI Sbjct: 103 GHTLERSVFSERTEESSAVQ-YFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKI 161 Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHL 121 VLDVGCG+GILS FAA+ GA+ + V+ S++ + A+ LV+ N +D+I ++ GK+E+V L Sbjct: 162 VLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSL 221 Query: 122 PFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDE 181 P +VDIIISE MGY L E M+++ L+A+ YL G +FP +HLA D Q E Sbjct: 222 P-EQVDIIISEPMGYMLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQLYME 279 Query: 182 ---KLNYW--QDVYGFDYSPF----VPLVLHEPIVDTVERNNVNTTSDKL-------IEF 225 K N+W +G D S V +P+VDT + + S K E Sbjct: 280 QFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEG 339 Query: 226 DLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWK 285 DL+ ++I FK +++G+ WFD+ F V ST P P THW Sbjct: 340 DLHRIEIP-------FKFHMLHSGLVHGLAFWFDVAFIG--SIMTVWLSTAPTEPLTHWY 390 Query: 286 QTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESN 330 Q F L A+ GDT+ G + N++ + D++I + Sbjct: 391 QVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGS 435 >5IS8-A nrPDB Length = 381 Score = 344 bits (883), Expect = 2e-95, Method: Composition-based stats. Identities = 124/346 (35%), Positives = 182/346 (52%), Gaps = 28/346 (8%) Query: 1 MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDK 60 M T + +E+T+ S + Q YF Y + + M+QD VRT +Y+ AI+QN FKDK Sbjct: 3 MGHTLERSVFSERTEESSAVQ-YFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDK 61 Query: 61 IVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVH 120 IVLDVGCG+GILS FAA+ GA+ + V+ S++ + A+ LV+ N +D+I ++ GK+E+V Sbjct: 62 IVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVS 121 Query: 121 LPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKD 180 LP +VDIIISE MGY L E M+++ L+A+ YL G +FP +HLA D Q Sbjct: 122 LP-EQVDIIISEPMGYMLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQLYM 179 Query: 181 E---KLNYW--QDVYGFDYSPF----VPLVLHEPIVDTVERNNVNTTSDKL-------IE 224 E K N+W +G D S V +P+VDT + + S K E Sbjct: 180 EQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKE 239 Query: 225 FDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHW 284 DL+ ++I FK +++G+ WFD+ F V ST P P THW Sbjct: 240 GDLHRIEIP-------FKFHMLHSGLVHGLAFWFDVAFIG--SIMTVWLSTAPTEPLTHW 290 Query: 285 KQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESN 330 Q F L A+ GDT+ G + N++ + D++I + Sbjct: 291 YQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGS 336 >4IKP-A nrPDB Length = 341 Score = 328 bits (840), Expect = 3e-90, Method: Composition-based stats. Identities = 121/334 (36%), Positives = 177/334 (52%), Gaps = 28/334 (8%) Query: 13 KTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGIL 72 +T+ S + Q YF Y + + M+QD VRT +Y+ AI+QN FKDKIVLDVGCG+GIL Sbjct: 1 RTEESSAVQ-YFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGIL 59 Query: 73 SMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISE 132 S FAA+ GA+ + V+ S++ + A+ LV+ N +D+I ++ GK+E+V LP +VDIIISE Sbjct: 60 SFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLP-EQVDIIISE 118 Query: 133 WMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDE---KLNYW--Q 187 MGY L E M+++ L+A+ YL G +FP +HLA D Q E K N+W Sbjct: 119 PMGYMLFNERMLESYLHAK-KYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQP 177 Query: 188 DVYGFDYSPF----VPLVLHEPIVDTVERNNVNTTSDKL-------IEFDLNTVKISDLA 236 +G D S V +P+VDT + + S K E DL+ ++I Sbjct: 178 SFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIP--- 234 Query: 237 FKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLD 296 FK +++G+ WFD+ F V ST P P THW Q F L Sbjct: 235 ----FKFHMLHSGLVHGLAFWFDVAFIG--SIMTVWLSTAPTEPLTHWYQVRCLFQSPLF 288 Query: 297 AETGDTIEGELVCSPNEKNNRDLNIKISYKFESN 330 A+ GDT+ G + N++ + D++I + Sbjct: 289 AKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGS 322 >3R0Q-C nrPDB Length = 376 Score = 304 bits (779), Expect = 3e-83, Method: Composition-based stats. Identities = 101/346 (29%), Positives = 174/346 (50%), Gaps = 28/346 (8%) Query: 22 HYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA 81 YF +Y ++ML D VR +Y NA+ QNK F+ K VLDVG G+GIL++++A+ GA Sbjct: 27 QYFCTYSFLYHQKDMLSDRVRMDAYFNAVFQNKHHFEGKTVLDVGTGSGILAIWSAQAGA 86 Query: 82 KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYE 141 + V V+ + + + A+ LV+ N + ++ G +ED+ LP KVD+IISEWMGYFLL E Sbjct: 87 RKVYAVEATKMADHARALVKANNLDHIVEVIEGSVEDISLP-EKVDVIISEWMGYFLLRE 145 Query: 142 SMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNY------WQDV------ 189 SM D+V+ ARD +L G+++P + LA ++ + ++ ++ W + Sbjct: 146 SMFDSVISARDRWLKPTGVMYPSHARMWLAPIKSNIADRKRNDFDGAMADWHNFSDEIKS 205 Query: 190 -YGFDYSPFVPLVLHEPIV--------DTVERNNVNTTSDKLIEFDLNTVKISDL-AFKS 239 YG D E + + + T + E D T +S++ +S Sbjct: 206 YYGVDMGVLTKPFAEEQEKYYIQTAMWNDLNPQQIIGTPTIVKEMDCLTASVSEIEEVRS 265 Query: 240 NFKLTA-KRQDMINGIVTWFDIVFPAPKG---KRPVEFSTGPHAPY-THWKQTIFYFPDD 294 N + G WFD+ F K ++ +E +T P + THW Q +F + Sbjct: 266 NVTSVINMEHTRLCGFGGWFDVQFSGRKEDPAQQEIELTTAPSEQHCTHWGQQVFIMSNP 325 Query: 295 LDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGIDGNSRSRK 340 ++ E GD + L+ S +++N+R + I+++ + + + +K Sbjct: 326 INVEEGDNLNLGLLMSRSKENHRLMEIELNCEIKEASGNPKESFKK 371 >4LWO-B nrPDB Length = 368 Score = 263 bits (672), Expect = 8e-71, Method: Composition-based stats. Identities = 105/353 (29%), Positives = 166/353 (47%), Gaps = 59/353 (16%) Query: 17 SESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFA 76 S Y+ SY +H ML+D R YR +I Q+ + + K+V+DVG GTGILSM+A Sbjct: 14 SSLHHQYYESYSDLAVHRLMLEDAQRMSFYRKSIEQSASI-EGKVVVDVGSGTGILSMWA 72 Query: 77 AKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDV--------------HLP 122 A+ GAKHV ++ SS+ E +VE N S KIT+L +E++ L Sbjct: 73 ARAGAKHVFSIEASSLSEFQIGVVEDNDLSTKITVLGDTVENIIAGGVANFVNRHKAKLG 132 Query: 123 FPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGG--------LIFPDKCSIHLAGLE 174 V +++SEWMG++L +E M+ +V+ AR+ + + P++ ++ +A + Sbjct: 133 KCGVAVLLSEWMGFYLFHEGMLPSVIRARNFFQDVNAALGVLQPIEMIPERATVFVAPIT 192 Query: 175 DSQYKDEKL-NYWQDVYGFDYSPF------VPLVLHEPIVDTVERNNVNTTSDKLIEFDL 227 Y ++ N+W+DV G D+S + V L P+V+ + + LIE +L Sbjct: 193 CKPYYVQRYKNFWRDVDGLDFSRYGRIEYEVYLEQASPLVECLPPLCLLHEGLSLIELNL 252 Query: 228 NTVKIS-----------DLAFKSNFKLTAKRQD-----MINGIVTWFDIVFPAPKGKRPV 271 +TV+ DL + F+ A+ ++G WFD+ + A Sbjct: 253 STVQEEVLTSLHNTVHFDLKESAEFQQHAREAGSEGRVSVDGFTVWFDVSYGAHT----- 307 Query: 272 EFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKIS 324 ST P +P THWKQT P + E ELV P E + + IS Sbjct: 308 -LSTSPRSPSTHWKQTTILLPREARNE-------ELVSFPVEGGELGVEMHIS 352 >3X0D-A nrPDB Length = 655 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 69/330 (20%), Positives = 136/330 (41%), Gaps = 29/330 (8%) Query: 10 ATEKTKLSESEQHYFNSYDHYGIHEE--------MLQDTVRTLSYRNAI-----IQNKDL 56 EK E+ + + + Y + +E M+ D R + + + + Sbjct: 10 FLEKINQKTGEREWVVAEEDYDMAQELARSRFGDMILDFDRNDKFLAGLKTTIAEKKHEN 69 Query: 57 FKDKI-VLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFSDKITLLRG 114 K+ VLD+G GTG+LS+ AA+ GA V +++ + + A+ + + +SDKIT++ Sbjct: 70 TDGKVHVLDIGTGTGLLSLMAAREGADKVTALEVFKPMGDCARHITSNSPWSDKITVISE 129 Query: 115 KLEDV-HLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGL 173 + DV + + DII++E L+ E + T A + G + P ++++ + Sbjct: 130 RSTDVSQIGGSRADIIVAEVFDTELIGEGALRTFKEALERLAKPGCRVVPSTGNVYIVPV 189 Query: 174 EDSQYKD----EKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNT 229 E K +LN +D V + + ++ + S+ ++ F + Sbjct: 190 ESHLLKMFNDIPRLNGEKDEEPLGRCSGTAAVFDVQLSE-MKTHEFRELSEPIVAFKFDF 248 Query: 230 VKISDLAFKSNF--KLTAKRQDMINGIVTWFDIVFPAPKGK----RPVEFSTGPHAPYTH 283 + F +F + A I+ ++ W+DI P + +A H Sbjct: 249 EHEEKIIFDESFVREAVAHSSGTIDALLMWWDIDMDRNGTTFIDMGPKWKNKNNYAWRDH 308 Query: 284 WKQTIFYFPDDLDAETGDTIEGELVCSPNE 313 W Q ++Y P+ E T E+VC+ +E Sbjct: 309 WMQAVYYLPEKKKVEMNQTF--EIVCNHDE 336 >5EKU-A nrPDB Length = 390 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 124/294 (42%), Gaps = 20/294 (6%) Query: 31 GIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS 90 H M+ D R Y + K + + VL++G G+G+LS+ AAK GAK V+ V+ S Sbjct: 70 DFHYAMMNDEERNNFYYEVL--KKHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGS 127 Query: 91 S-IIEMAKELVELNGFSDKITLLR---GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDT 146 + ++A+E + N ++ +L +L+ HLP P D+++SE G +L ES +D Sbjct: 128 EELAKLARENIRANNMEHQVKVLHMMSTELKPKHLPEPP-DVLLSEIFGTMMLGESALDY 186 Query: 147 VLYARDHYLVEGGLIFPDKCSIHLAGLE-DSQYKDEKLNYWQDV---YGFDYSPFVPLVL 202 V+ R+ L I P + + +E D+ ++ ++ W+D+ + V +V Sbjct: 187 VVDVRNRLLKPTTKIIPQFGTQYAVPIECDALHRISSVSGWRDLDLKHMMTLQDTVSIVF 246 Query: 203 HEPIVDTVERNNVNTTSDK--LIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDI 260 + + N SD L D ++ +D++ + +F + AK + ++ ++ + Sbjct: 247 AKHYGIRMNSVNFRRLSDPIELFRVDFSSSNRNDISRRKHFDVVAKESGTAHAMLFYWKV 306 Query: 261 VFPAPKGKRPVEFSTGPHAPYTHWKQTIFY-------FPDDLDAETGDTIEGEL 307 E + W Q + P + G E Sbjct: 307 TDDEFVMSTDPEDTVNNFPRDMQWGQALQLLDASNGPLPTPVVFTEGKNYNFEC 360 >6OGN-A nrPDB Length = 692 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 77/338 (22%), Positives = 135/338 (39%), Gaps = 56/338 (16%) Query: 9 SATEKTKLSESEQHYFNSYDHYGIHEE--------MLQDTVRTLSY----RNAIIQNKDL 56 + + + +HY H+E ML D R + Y R A+ + KD Sbjct: 3 VFCGRANPTTGSLEWLEEDEHYDYHQEIARSSYADMLHDKDRNIKYYQGIRAAVSRVKDR 62 Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFSDKITLLRGK 115 + +VLD+G GTG+LSM A GA +++ + E A ++VE NGFSDKI ++ Sbjct: 63 GQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINKH 122 Query: 116 LEDVHLPF-----PKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHL 170 +V + + +I+I+E L+ E + + +A H + E P + +++ Sbjct: 123 STEVTVGPDGDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYA 182 Query: 171 AGLEDSQYKDEKLNYWQDVYG------FDYSPFVPLVLHE-----PIVDTVERNNVNT-- 217 +E ++ W ++ VP E P V ++ N V+ Sbjct: 183 QLVES-----RRMWSWNKLFPVRVRTSLGEQVIVPPSELERCPGAPSVCDIQLNQVSPAD 237 Query: 218 ---TSDKLIEFDLN---TVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPV 271 SD L F ++ V S F A Q + +++W+DI P+GK + Sbjct: 238 FTVLSDVLPMFSVDFSKQVSSSAACHSRQFVPLASGQAQV--VLSWWDIEM-DPEGK--I 292 Query: 272 EFSTGPHA---------PYTHWKQTIFYFPDDLDAETG 300 + + P HW Q +++ P + G Sbjct: 293 KCTMAPFWAQTDPQELQWRDHWMQCVYFLPQEEPVVQG 330 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 92/282 (32%), Gaps = 24/282 (8%) Query: 37 LQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIE-M 95 + D RT Y A+ L + L V G+ +LSM A GA+ V V+ S + Sbjct: 382 INDQDRTDHYAQALRTV--LLPGSVCLCVSDGS-LLSMLAHHLGAEQVFTVESSVASYRL 438 Query: 96 AKELVELNGFSDKITLLRGKLEDV---HLPFPKVDIIISEWMGYFLL---YESMMDTVLY 149 K + ++N DKI+++ + E + L KV +++ E L + V Sbjct: 439 MKRIFKVNHLEDKISVINKRPELLTAADLEGKKVSLLLGEPFFTTSLLPWHNLYFWYVRT 498 Query: 150 ARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQ----DVYGFDYSPFVPLVLHEP 205 + D +L G ++ P S+H +E + DV+ D L E Sbjct: 499 SVDQHLAPGAVVMPQAASLHAVIVEFRDLWRIRSPCGDCEGFDVHIMDDMIKHSLDFRES 558 Query: 206 IVDTVERNNVNTT-----SDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDI 260 +++ FD + R +G V W + Sbjct: 559 REAEPHPLWEYPCRSLSKPQEILTFDFQQPIPQQPMQSKG-TMELTRPGKSHGAVLWMEY 617 Query: 261 VFPAPKGKRPVEFS----TGPHAPYTHWKQTIFYFPDDLDAE 298 + G H KQ +++ LD Sbjct: 618 QLTPDSTISTGLINPAEDKGDCCWNPHCKQAVYFLSTTLDLR 659 >4M36-A nrPDB Length = 343 Score = 206 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 123/294 (41%), Gaps = 20/294 (6%) Query: 31 GIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS 90 H M+ D R Y + K + + VL++G G+G+LS+ AAK GAK V+ V+ S Sbjct: 35 DFHYAMMNDEERNNFYYEVL--KKHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGS 92 Query: 91 S-IIEMAKELVELNGFSDKITLLR---GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDT 146 + ++A+E + N ++ +L +L+ HLP P D+++SE G +L ES +D Sbjct: 93 EELAKLARENIRANNMEHQVKVLHMMSTELKSKHLPEPP-DVLLSEIFGTMMLGESALDY 151 Query: 147 VLYARDHYLVEGGLIFPDKCSIHLAGLE-DSQYKDEKLNYWQDV---YGFDYSPFVPLVL 202 V+ R+ L I P + + +E D+ ++ ++ W+D+ + V +V Sbjct: 152 VVDVRNRLLKPTTKIIPQFGTQYAVPIECDALHRISSVSGWRDLDLKHMMTLQDTVSIVF 211 Query: 203 HEPIVDTVERNNVNTTSDK--LIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDI 260 + + N SD L D ++ +D+ + +F + AK + ++ ++ + Sbjct: 212 AKHYGIRMNSVNFRRLSDPIELFRVDFSSSNRNDIPRRKHFDVVAKESGTAHAMLFYWKV 271 Query: 261 VFPAPKGKRPVEFSTGPHAPYTHWKQTIFY-------FPDDLDAETGDTIEGEL 307 E + W Q + P + G E Sbjct: 272 TDDEFVMSTDPEDTVNNFPRDMQWGQALQLLDASNGPLPTPVVFTEGKNYNFEC 325 >4G56-A nrPDB Length = 657 Score = 187 bits (475), Expect = 5e-48, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 114/288 (39%), Gaps = 42/288 (14%) Query: 33 HEEMLQDTVRTLSYRNAII-----QNKDLFKD---KIVLDVGCGTGIL---SMFAAKHGA 81 +E +D V+ Y+ A+ + + K+ +I++ +G G G L S+ AAK Sbjct: 344 YEVFEKDPVKYSQYQQAVYKCLLDRVPEEEKETNIQILMVLGAGRGPLVNASLRAAKQAE 403 Query: 82 KH--VIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLL 139 + V V+ + + E + ++T++ G + + P K DII+SE +G F Sbjct: 404 RKIKVYAVEKNPNAVITLEGWRYEEWGSQVTVVSGDMREWKAP-EKADIIVSELLGSFGD 462 Query: 140 YESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDE---------------KLN 184 E + L H+L + G+ P + + +LA + S+ +E ++ Sbjct: 463 NE-LSPECLDGAQHFLKDDGVSIPGEYTSYLAPISSSKLYNEVRACREKDRDPEAQFEMP 521 Query: 185 YWQDVYGFDY--SPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTV-----KISDLAF 237 Y ++ F P H P D V NN DLNTV + Sbjct: 522 YVVRLHNFHQLSDPLPCFTFHHPNKDDVIDNNRYCCLQY--RVDLNTVLHGFAGYFNTVL 579 Query: 238 KSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWK 285 + L+ + G+ +WF I+FP K+P+ G W+ Sbjct: 580 YKDVTLSICPESHSPGMFSWFPILFPI---KQPIPMREGDTVCVRFWR 624 >5FA5-A nrPDB Length = 650 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 114/286 (39%), Gaps = 38/286 (13%) Query: 33 HEEMLQDTVRTLSYRNAII-----QNKDLFKD---KIVLDVGCGTGIL---SMFAAKHGA 81 +E +D ++ Y+ AI + + KD ++++ +G G G L S+ AAK Sbjct: 337 YEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQAD 396 Query: 82 KHV--IGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLL 139 + + V+ + + E + + ++T++ + + P K DII+SE +G F Sbjct: 397 RRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAP-EKADIIVSELLGSFAD 455 Query: 140 YESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDE---------------KLN 184 E + L H+L + G+ P + + LA + S+ +E ++ Sbjct: 456 NE-LSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMP 514 Query: 185 YWQDVYGFDY--SPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLN---TVKISDLAFKS 239 Y ++ F +P P D + NN T + +E + + Sbjct: 515 YVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQ 574 Query: 240 NFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWK 285 + L+ + + G+ +WF I+FP K+P+ G W+ Sbjct: 575 DITLSIRPETHSPGMFSWFPILFPI---KQPITVREGQTICVRFWR 617 >3SVZ-A nrPDB Length = 263 Score = 144 bits (362), Expect = 7e-35, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 85/212 (40%), Gaps = 17/212 (8%) Query: 44 LSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVEL 102 + R A+ +L D + D+GCGTG ++F A + + G+D+ IE+ E Sbjct: 38 EATRKAVSFINELTDDAKIADIGCGTGGQTLFLADYVKGQITGIDLFPDFIEIFNENAVK 97 Query: 103 NGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 +D++ + G ++++ ++D+I SE Y + +E M+ YL +GG I Sbjct: 98 ANCADRVKGITGSMDNLPFQNEELDLIWSEGAIYNIGFERGMNEW----SKYLKKGGFI- 152 Query: 163 PDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKL 222 ++ A S+ E ++W D Y + + +D +ER T+ + Sbjct: 153 ----AVSEASWFTSERPAEIEDFWMDAY-------PEISVIPTCIDKMERAGYTPTAHFI 201 Query: 223 IEFDLNTVKISDLAFKSNFKLTAKRQDMINGI 254 + + T + + + Sbjct: 202 LPENCWTEHYFAPQDEVRETFMKEHAGNKTAM 233 >3BKW-A nrPDB Length = 243 Score = 111 bits (276), Expect = 7e-25, Method: Composition-based stats. Identities = 40/152 (26%), Positives = 64/152 (42%), Gaps = 13/152 (8%) Query: 23 YFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAK 82 +F Y G E L + R + + L ++D+GCG G +A +HGA Sbjct: 12 FFAGYSQLGRSIEGLDGAAEWPALRAMLPEVGGL----RIVDLGCGFGWFCRWAHEHGAS 67 Query: 83 HVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFL-LYE 141 +V+G+D+S E G IT R L+ +HLP D+ S +++ Sbjct: 68 YVLGLDLS---EKMLARARAAGPDTGITYERADLDKLHLPQDSFDLAYSSLALHYVEDVA 124 Query: 142 SMMDTVLYARDHYLVEGG-LIFPDKCSIHLAG 172 + TV A L GG +F + I++A Sbjct: 125 RLFRTVHQA----LSPGGHFVFSTEHPIYMAP 152 >2AS0-A nrPDB Length = 396 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 38/127 (29%), Positives = 62/127 (48%), Gaps = 13/127 (10%) Query: 56 LFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRG 114 + VLDV TG ++ AA GA VIG+D S IE AKE +LNG D++ + G Sbjct: 215 VQPGDRVLDVFTYTGGFAIHAAIAGADEVIGIDKSPRAIETAKENAKLNGVEDRMKFIVG 274 Query: 115 ----KLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVL-------YARDHYLVEGGLIFP 163 ++E + K DI++ + F+ +E + L +A + + +GG++ Sbjct: 275 SAFEEMEKLQKKGEKFDIVVLDPPA-FVQHEKDLKAGLRAYFNVNFAGLNLVKDGGILVT 333 Query: 164 DKCSIHL 170 CS H+ Sbjct: 334 CSCSQHV 340 >5JE5-A nrPDB Length = 247 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 6/134 (4%) Query: 31 GIHEEMLQDTV-RTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM 89 G+ E+ Q R + R D+ K VLD+ CG G + GA V+GVD+ Sbjct: 14 GLFEDFTQSAAQRAIEVRTIFHMIGDV-SGKSVLDLACGFGFFGREIYRRGAAKVVGVDI 72 Query: 90 SS-IIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVL 148 S +IE+A+E E + D + + ++ P + D++ + W+ + + + Sbjct: 73 SEKMIELARE--ESRKYGDPLEFHVRDVANME-PLGQFDLVNAAWLFNYADSVENLRKMF 129 Query: 149 YARDHYLVEGGLIF 162 L G + Sbjct: 130 KVVRASLKPDGKLV 143 >3UA4-A nrPDB Length = 745 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 40/258 (15%), Positives = 82/258 (31%), Gaps = 42/258 (16%) Query: 83 HVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVH-----LPFPKVDIIISEWMGYF 137 + V+ + + + + + + ++T++ + + F + DII+SE +G F Sbjct: 448 KLYIVEKNPNAIVTLKYMNVRTWKRRVTIIESDMRSLPGIAKDRGFEQPDIIVSELLGSF 507 Query: 138 LLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQ----YKDEKLNYWQDVYGFD 193 E + L +L + P K + ++ + + K + + Y Sbjct: 508 GDNE-LSPECLDGVTGFLKPTTISIPQKYTSYVKPIMSTHIHQTIKAQSIPYLSRAIPSH 566 Query: 194 YSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLN-------TVKI-----------SDL 235 L E + + +V D++ L+ T K S Sbjct: 567 GRGEPELDEDEMWIQKYPQGHVRNNMDQIYVVYLSKYIPLAETTKPVFTFEHPNFMNSSN 626 Query: 236 AFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTH------WKQTIF 289 + + R + G +FD+ + V S P TH W + Sbjct: 627 ERSDSIEFVMDRNADLMGFAGYFDLQL-----YKTVMLS---IEPSTHTPGMVSWFPAVI 678 Query: 290 YFPDDLDAETGDTIEGEL 307 D L GD I ++ Sbjct: 679 PLRDQLRVGEGDRISLKI 696 >5WP4-A nrPDB Length = 491 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 43/210 (20%), Positives = 83/210 (39%), Gaps = 16/210 (7%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELVELNGFSDK 108 ++ +L + VLDVGCG G + A+ HV+G+D+S ++I A E G S Sbjct: 274 FVEKMNLKPGQKVLDVGCGIGGGDFYMAEKFDVHVVGIDLSVNMISFALE--RAIGLSCS 331 Query: 109 ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGG-LIFPDKCS 167 + H P D+I S +L+ + +L GG ++ D C Sbjct: 332 VEFEVADCTTKHYPDNSFDVIYSR---DTILHIQDKPALFRTFFKWLKPGGKVLISDYCR 388 Query: 168 IHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDL 227 + ++ Y D++ D + + L + V + ++++ +L Sbjct: 389 SPKTPSAEFSEYIKQRGY--DLH--DVQAYGQM-LKDAGFTDVIAEDRTDQFMQVLKREL 443 Query: 228 NTVKISDLAFKSNFKLTAKRQDMINGIVTW 257 + V+ F S+F ++D + + W Sbjct: 444 DRVEKEKEKFISDFS----KEDYDDIVGGW 469 Score = 44.4 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 65/172 (37%), Gaps = 22/172 (12%) Query: 9 SATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTL--SYRNAIIQNKDLFKDKIVLDVG 66 +A+ + + + ++ + ML L R ++ ++ K VL++G Sbjct: 2 AASYEEERDIQKNYWIEHSADLTVEAMMLDSRASDLDKEERPEVLSLLPPYEGKSVLELG 61 Query: 67 CGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLE--DVHLPFP 124 G G + A+ A +I +D + E + NG + + + D+ + Sbjct: 62 AGIGRFTGELAQK-AGELIALDFIDNVIKKNESI--NGHYKNVKFMCADVTSPDLKITDG 118 Query: 125 KVDIIISEWMGYF-------LLYESMMDTVLYARDHYLVEGGLIFPDKCSIH 169 +D+I S W+ + LL E M+ ++ GG IF + H Sbjct: 119 SLDLIFSNWLLMYLSDKEVELLAERMVG--------WIKVGGYIFFRESCFH 162 >5WP5-A nrPDB Length = 491 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 35/177 (19%), Positives = 61/177 (34%), Gaps = 11/177 (6%) Query: 20 EQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNK--DLFKDKIVLDVGCGTGILSMFAA 77 + + S + V T + DL + VLDVGCG G + A Sbjct: 242 DNVQYKSSGILRYERVFGEGYVSTGGFETTKEFVAKMDLKPGQKVLDVGCGIGGGDFYMA 301 Query: 78 KHGAKHVIGVDMS-SIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGY 136 ++ HV+G+D+S ++I A E G + P D+I S Sbjct: 302 ENFDVHVVGIDLSVNMISFALE--RAIGLKCSVEFEVADCTTKTYPDNSFDVIYSR---D 356 Query: 137 FLLYESMMDTVLYARDHYLVEGG-LIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGF 192 +L+ + +L GG ++ D C + ++ Y D++ Sbjct: 357 TILHIQDKPALFRTFFKWLKPGGKVLITDYCRSAETPSPEFAEYIKQRGY--DLHDV 411 Score = 50.9 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 32/161 (19%), Positives = 61/161 (37%), Gaps = 8/161 (4%) Query: 13 KTKLSESEQHYFNSYDHYGIHEEMLQDTVRTL--SYRNAIIQNKDLFKDKIVLDVGCGTG 70 K + + ++ + ML L R ++ ++ K VL++G G G Sbjct: 6 KEERDIQKSYWMEHSSDLTVEAMMLDSKASDLDKEERPEVLSLIPPYEGKSVLELGAGIG 65 Query: 71 ILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLE--DVHLPFPKVDI 128 + A+ A VI +D E V NG I + + D+ + +D+ Sbjct: 66 RFTGELAQK-AGEVIALDFIESAIQKNESV--NGHYKNIKFMCADVTSPDLKIKDGSIDL 122 Query: 129 IISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIH 169 I S W+ +L + ++ + ++ GG IF + H Sbjct: 123 IFSNWLLMYL-SDKEVELMAERMIGWVKPGGYIFFRESCFH 162 >1L3B-A nrPDB Length = 192 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 8/123 (6%) Query: 41 VRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKEL 99 + R I+ + K+ + +DVGCGTG +++ A + V +D + I + Sbjct: 16 PTAMEVRCLIMCLAEPGKNDVAVDVGCGTGGVTLELAGRV-RRVYAIDRNPEAISTTEMN 74 Query: 100 VELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGG 159 ++ +G D +TL+ G + P +DI + G + +L L GG Sbjct: 75 LQRHGLGDNVTLMEGDAPEALCKIPDIDIAVVGGSG------GELQEILRIIKDKLKPGG 128 Query: 160 LIF 162 I Sbjct: 129 RII 131 >1WXW-A nrPDB Length = 382 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 27/127 (21%), Positives = 49/127 (38%), Gaps = 13/127 (10%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELVELNGFSDKITLLR 113 + F+ + LDV G ++ A G + V+ VD S + A+E LNG + + +L Sbjct: 206 ERFRGERALDVFSYAGGFALHLA-LGFREVVAVDSSAEALRRAEENARLNGLGN-VRVLE 263 Query: 114 GK----LEDVHLPFPKVDIIISEWMGYFLLY---ESMMDTVLYARDH---YLVEGGLIFP 163 L + + D+++ + + E L EGG++ Sbjct: 264 ANAFDLLRRLEKEGERFDLVVLDPPAFAKGKKDVERAYRAYKEVNLRAIKLLKEGGILAT 323 Query: 164 DKCSIHL 170 CS H+ Sbjct: 324 ASCSHHM 330 >3D2L-A nrPDB Length = 243 Score = 54.8 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 34/146 (23%), Positives = 64/146 (43%), Gaps = 9/146 (6%) Query: 26 SYDHYG-IHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHV 84 +Y+ + +++E++QD + Q + K + D+GCGTG ++ A H V Sbjct: 3 AYEQFAYVYDELMQDVPYPEWVAWVLEQVE---PGKRIADIGCGTGTATLLLADH--YEV 57 Query: 85 IGVDMS-SIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESM 143 GVD+S ++E+A+E + + ++ LP P I I +L E+ Sbjct: 58 TGVDLSEEMLEIAQEKAMETN--RHVDFWVQDMRELELPEPVDAITILCDSLNYLQTEAD 115 Query: 144 MDTVLYARDHYLVEGGLIFPDKCSIH 169 + + L +GG + D S + Sbjct: 116 VKQTFDSAARLLTDGGKLLFDVHSPY 141 >3MGG-A nrPDB Length = 276 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 29/142 (20%), Positives = 55/142 (38%), Gaps = 10/142 (7%) Query: 22 HYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA 81 Y + Y E L+ + + + + + VL+ GCG G ++ AK+ Sbjct: 5 EYVHGYSE----REALRLSEQAETLEKLLHHDTVYPPGAKVLEAGCGIGAQTVILAKNNP 60 Query: 82 K-HVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLL 139 + +D+S +E A+E E NG + + L+ + + D I + + L Sbjct: 61 DAEITSIDISPESLEKARENTEKNGIKN-VKFLQANIFSLPFEDSSFDHIF---VCFVLE 116 Query: 140 YESMMDTVLYARDHYLVEGGLI 161 + + L + L GG I Sbjct: 117 HLQSPEEALKSLKKVLKPGGTI 138 >3DLC-A nrPDB Length = 219 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 24/101 (23%), Positives = 47/101 (46%), Gaps = 4/101 (3%) Query: 63 LDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKLEDVHL 121 +D+G G G LS+ AK + +D S + E+A + + +D+I +++G + ++ + Sbjct: 48 IDIGSGPGALSIALAKQSDFSIRALDFSKHMNEIALKNIADANLNDRIQIVQGDVHNIPI 107 Query: 122 PFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 D+I+S G +E + T L GG + Sbjct: 108 EDNYADLIVSR--GSVFFWE-DVATAFREIYRILKSGGKTY 145 >3CJR-A nrPDB Length = 254 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 11/110 (10%) Query: 54 KDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSII-EMAKELVELNGFSDKITLL 112 + L VLD+G G+G+L++ A K G +GVD+ ++ A+ + NG + L Sbjct: 116 RHLRPGDKVLDLGTGSGVLAIAAEKLG-GKALGVDIDPMVLPQAEANAKRNGV--RPRFL 172 Query: 113 RGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 G LE LPF D++++ Y L+ ++ A LV GG Sbjct: 173 EGSLE-AALPFGPFDLLVANL--YAELHAALAPRYREA----LVPGGRAL 215 >4P7C-A nrPDB Length = 322 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 36/138 (26%), Positives = 52/138 (37%), Gaps = 8/138 (5%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKL 116 K K VLDVGCG G GA VIGVD + + + ++ L L Sbjct: 120 LKGKRVLDVGCGNGYYQWRMLGAGADSVIGVDPNWLFFCQFQAMQRYLPDLPAWHLPFAL 179 Query: 117 EDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEG-----GLIFPDKCSIHLA 171 ED+ D + S MG +S +D +L +D + G L+ P L Sbjct: 180 EDLPANLEGFDTVFS--MGVLYHRKSPIDHLLALKDCLVKGGELVMETLVIPGDVHQVLV 237 Query: 172 GLEDSQYKDEKLNYWQDV 189 ED + + + V Sbjct: 238 P-EDRYAQMRNVWFLPSV 254 >3BUS-A nrPDB Length = 273 Score = 51.7 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 31/155 (20%), Positives = 57/155 (36%), Gaps = 10/155 (6%) Query: 29 HYGIHEEMLQD---TVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVI 85 H+G E+ D T + +I D+ VLDVGCG G ++ A V Sbjct: 29 HFGYWEDAGADVSVDDATDRLTDEMIALLDVRSGDRVLDVGCGIGKPAVRLATARDVRVT 88 Query: 86 GVDMS-SIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIIS-EWMGYFLLYESM 143 G+ +S + A G ++++T D+ D + + E + + Sbjct: 89 GISISRPQVNQANARATAAGLANRVTFSYADAMDLPFEDASFDAVWALESLHHMPDRGRA 148 Query: 144 MDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQY 178 + + L GG + + LA +E ++ Sbjct: 149 LREM----ARVLRPGGTVAIADF-VLLAPVEGAKK 178 >4PNE-A nrPDB Length = 302 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 25/104 (24%), Positives = 43/104 (41%), Gaps = 4/104 (3%) Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKELVELNGFSDKITLLRGKLE 117 +LDVGCGTG ++ A+ A + G+ +S + + +A + G S ++ Sbjct: 93 GVRLLDVGCGTGQPALRVARDNAIQITGITVSQVQVAIAADCARERGLSHRVDFSCVDAM 152 Query: 118 DVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLI 161 + P D + W LL S D + L GG++ Sbjct: 153 SLPYPDNAFD---AAWAMQSLLEMSEPDRAIREILRVLKPGGIL 193 >3A27-A nrPDB Length = 272 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 34/177 (19%), Positives = 67/177 (37%), Gaps = 19/177 (10%) Query: 15 KLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSM 74 K +E+ + + + M R A I N ++++V+D+ G G ++ Sbjct: 80 KETETIHKEYGCLFKLDVAKIMWSQGNIEERKRMAFISN----ENEVVVDMFAGIGYFTI 135 Query: 75 FAAKHGAKH-VIGVDMSSIIEMAK-ELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISE 132 AK+ V ++ + E ++LN ++ I +L DV L D+ Sbjct: 136 PLAKYSKPKLVYAIEKNPTAYHYLCENIKLNKLNNVIPIL-ADNRDVELK----DVADRV 190 Query: 133 WMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCS----IHLAGLEDSQYKDEKLNY 185 MGY +D +L + G+I + ++ +E ++ EK Y Sbjct: 191 IMGYVHKTHKFLDKTFE----FLKDRGVIHYHETVAEKIMYERPIERLKFYAEKNGY 243 >4FGZ-A nrPDB Length = 266 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 33/129 (25%), Positives = 53/129 (41%), Gaps = 6/129 (4%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVD-MSSIIEMAKELVELNGFSDK 108 I+ + +L ++ VLD+G G G M+ + H G+D S+I+ MA E V N K Sbjct: 47 ILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNN---K 103 Query: 109 ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGG-LIFPDKCS 167 I + P D+I S L E+ + + +L G L+ D C+ Sbjct: 104 IIFEANDILTKEFPENNFDLIYSRDAILHLSLENK-NKLFQKCYKWLKPTGTLLITDYCA 162 Query: 168 IHLAGLEDS 176 +D Sbjct: 163 TEKENWDDE 171 >1I9G-A nrPDB Length = 280 Score = 50.9 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 30/124 (24%), Positives = 49/124 (39%), Gaps = 13/124 (10%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHG--AKHVIGVDM-SSIIEMAKELVE--LNG 104 I+ D+F VL+ G G+G L++ + A VI + + E A+ V Sbjct: 91 IVHEGDIFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNVSGCYGQ 150 Query: 105 FSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPD 164 D L+ L D LP VD + + + + VL A LV GG++ Sbjct: 151 PPDNWRLVVSDLADSELPDGSVDRAVLDMLAPW--------EVLDAVSRLLVAGGVLMVY 202 Query: 165 KCSI 168 ++ Sbjct: 203 VATV 206 >2AVN-A nrPDB Length = 260 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 33/148 (22%), Positives = 59/148 (39%), Gaps = 11/148 (7%) Query: 24 FNSYDHYGIHEEMLQDTVRTLSYRNAI--IQNKDLFKDKIVLDVGCGTGILSMFAAKHGA 81 + YD + + +T + Y I + L VLD+G GTG S+F + G Sbjct: 18 WEFYDRIARAYDSMYETPKWKLYHRLIGSFLEEYLKNPCRVLDLGGGTGKWSLFLQERGF 77 Query: 82 KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYE 141 + V+ ++E+A+E N ++ K ED+ P + +++ +G L Y Sbjct: 78 EVVLVDPSKEMLEVAREKGVKN-------VVEAKAEDLPFPSGAFEAVLA--LGDVLSYV 128 Query: 142 SMMDTVLYARDHYLVEGGLIFPDKCSIH 169 D LV GL+ + + Sbjct: 129 ENKDKAFSEIRRVLVPDGLLIATVDNFY 156 >5Z9O-A nrPDB Length = 399 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 37/175 (21%), Positives = 63/175 (36%), Gaps = 18/175 (10%) Query: 3 KTAVKDSATEKTKLSESEQHYFNSYDHYGIHEE--------MLQDTVRTLSYRNAIIQNK 54 K K TEK + + HY D Y + + D + + I + Sbjct: 96 KFLPKSKHTEKQSEEDVQSHYDIGNDFYKLWLDPTMTYSCAYFTDDNKDDLEQAQIAKVH 155 Query: 55 DLF------KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELVELNGFSD 107 + K K +LD+GCG G L + AAK V GV +S ++ ++ + G D Sbjct: 156 HILNKLHPEKGKTLLDIGCGWGTLMLTAAKEYGLKVTGVTLSEEQYKLVQKKIYDEGLED 215 Query: 108 KITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + + L + D + S M + E++ + YL G+ Sbjct: 216 VAEVKLEDYRE--LGDQQWDYVTSVGMFEHVGSENLGEYFKDVA-KYLKNDGVAL 267 >2ZZN-A nrPDB Length = 336 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 3/67 (4%) Query: 61 IVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKLEDV 119 +V+D+ G G S+ AK + +D++ IE+ K+ ++LN KI + + +V Sbjct: 198 VVVDMFAGVGPFSIAC--KNAKKIYAIDINPHAIELLKKNIKLNKLEHKIIPILSDVREV 255 Query: 120 HLPFPKV 126 + +V Sbjct: 256 DVKGNRV 262 >3LPM-A nrPDB Length = 259 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 38/75 (50%), Gaps = 3/75 (4%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKL 116 + ++D+ G GI+ + + ++GV++ + +MAK V N D+I ++ L Sbjct: 49 RKGKIIDLCSGNGIIPLLLSTRTKAKIVGVEIQERLADMAKRSVAYNQLEDQIEIIEYDL 108 Query: 117 EDVH--LPFPKVDII 129 + + +P + DI+ Sbjct: 109 KKITDLIPKERADIV 123 >5GM1-A nrPDB Length = 297 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 38/200 (19%), Positives = 77/200 (38%), Gaps = 19/200 (9%) Query: 44 LSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELVEL 102 Y + +I+ D + +LD+GCGTG ++ AA+ V GV +S I A L Sbjct: 63 DRYTDYLIETLDPKAGQHLLDIGCGTGRTALKAARQRGIAVTGVAVSKEQIAAANRLAAG 122 Query: 103 NGFSDKITLLRGKLEDVHLPFPKVDIIIS-EWMGYFLLYESMMDTVLYARDHYLVEGGLI 161 +G ++++T + D + E + + +++ + L GG + Sbjct: 123 HGLTERLTFEVADAMRLPYEDESFDCAWAIESLCHMDRAKALGEAW-----RVLKPGGDL 177 Query: 162 FPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDK 221 + L + + + + ++ +Y + P + D V +T S K Sbjct: 178 ------LVLESVVTEELTEPETALFETLYAANVPPRLGEFF-----DIVSGAGFHTLSLK 226 Query: 222 LIEFDLN-TVKISDLAFKSN 240 + +L T+ + L S Sbjct: 227 DLSANLAMTMNVFALGVYSR 246 >3C0K-A nrPDB Length = 396 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 30/133 (22%), Positives = 56/133 (42%), Gaps = 12/133 (9%) Query: 47 RNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELVELNGF 105 R++ + + ++K VL+ TG ++ A G V+ VD S +++A++ VELN Sbjct: 209 RDSRLATRRYVENKRVLNCFSYTGGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKL 268 Query: 106 S-DKITLLRGKLEDV----HLPFPKVDIIISEWMGYFLLYESMMDTVLYARD------HY 154 K +R + + K D+I+ + + +M +D Sbjct: 269 DLSKAEFVRDDVFKLLRTYRDRGEKFDVIVMDPPKFVENKSQLMGACRGYKDINMLAIQL 328 Query: 155 LVEGGLIFPDKCS 167 L EGG++ CS Sbjct: 329 LNEGGILLTFSCS 341 >1DUS-A nrPDB Length = 194 Score = 48.2 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 29/145 (20%), Positives = 62/145 (42%), Gaps = 12/145 (8%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSD 107 +++N + KD +LD+GCG G++ + A + I++AKE ++LN + Sbjct: 42 KILVENVVVDKDDDILDLGCGYGVIGIALADEVKSTTMADINRRAIKLAKENIKLNNLDN 101 Query: 108 -KITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKC 166 I ++ L + ++ K + II+ + ++ ++ L + G I+ Sbjct: 102 YDIRVVHSDLYE-NVKDRKYNKIITNPPIR--AGKEVLHRIIEEGKELLKDNGEIW---- 154 Query: 167 SIHLAGLEDSQYKDEKLNYWQDVYG 191 ++ Q Y +DV+G Sbjct: 155 ----VVIQTKQGAKSLAKYMKDVFG 175 >3A26-A nrPDB Length = 301 Score = 47.5 bits (111), Expect = 9e-06, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 49/110 (44%), Gaps = 8/110 (7%) Query: 46 YRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSII-EMAKELVELNG 104 + + K D++V+D+ G G LS+ A +G VI ++ + E + LN Sbjct: 136 VKERVRMAKVAKPDELVVDMFAGIGHLSLPIAVYGKAKVIAIEKDPYTFKFLVENIHLNK 195 Query: 105 FSDKITLLRGKLEDVHLPFPK-VDIIISEWMGYFL-LYESMMDTVLYARD 152 D+++ +++ P D I+ MGY + +E + + A+D Sbjct: 196 VEDRMSAYN--MDNRDFPGENIADRIL---MGYVVRTHEFIPKALSIAKD 240 >4IV8-A nrPDB Length = 284 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 31/139 (22%), Positives = 50/139 (35%), Gaps = 7/139 (5%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFS-DK 108 I+ + L + VLD+G G G + + HV GVD I E + +L K Sbjct: 64 ILSDIYLEPNSKVLDIGSGLGGGCKYINEKYDAHVYGVD---ICEKMIAIAKLRNKDKSK 120 Query: 109 ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGG-LIFPDKCS 167 + + P D+I S L Y + + +L G L+ D C+ Sbjct: 121 VEFEAMDILKKDFPECTFDMIYSRDAILHLPY-ADKKKLFEKCYKWLKPNGILLITDYCA 179 Query: 168 IHLAGL-EDSQYKDEKLNY 185 + E+ + K Y Sbjct: 180 DKIENWDEEFKAYINKRKY 198 >6BQC-A nrPDB Length = 383 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 33/162 (20%), Positives = 57/162 (35%), Gaps = 15/162 (9%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSD 107 I + L VLD+GCG G L+ + A + V+GV +S+ + + G Sbjct: 158 KMICEKLQLKPGMRVLDIGCGWGGLAHYMASNYDVSVVGVTISAEQQKMAQE-RCEGLD- 215 Query: 108 KITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCS 167 +T+L D+ + D I+S M + + DT D L G+ Sbjct: 216 -VTILLQDYRDL---NDQFDRIVSVGM-FEHVGPKNYDTYFAVVDRNLKPEGIFLLHTI- 269 Query: 168 IHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDT 209 S+ D ++ W + Y F + + Sbjct: 270 -------GSKKTDLNVDPWINKYIFPNGCLPSVRQIAQSSEP 304 >4KDR-A nrPDB Length = 223 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 37/160 (23%), Positives = 66/160 (41%), Gaps = 19/160 (11%) Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITL--LRGKL 116 K VLDVGCG GIL+ A+ GA V G+D + ++ +L+ I + ++ + Sbjct: 63 GKKVLDVGCGGGILAESMAREGAT-VTGLD---MGFEPLQVAKLHALESGIQVDYVQETV 118 Query: 117 EDVHLP-FPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLED 175 E+ + D++ M L + +V+ A + GG +F +++ G++ Sbjct: 119 EEHAAKHAGQYDVVTCMEM---LEHVPDPQSVVRACAQLVKPGGDVF--FSTLNRNGVKK 173 Query: 176 SQYKDEKLNYWQD-------VYGFDYSPFVPLVLHEPIVD 208 E L + + G Y+P P VD Sbjct: 174 FIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVD 213 >1WY7-A nrPDB Length = 207 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 6/78 (7%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFSDKITLLRGKL 116 + K+V D+G GTG+LS A GAK VI V++ +++ E L F K + G + Sbjct: 49 EGKVVADLGAGTGVLSYGALLLGAKEVICVEVDKEAVDVLIEN--LGEFKGKFKVFIGDV 106 Query: 117 EDVHLPFPKVDIIISEWM 134 + +VDI+I Sbjct: 107 SEF---NSRVDIVIMNPP 121 >2P8J-A nrPDB Length = 209 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 47/126 (37%), Gaps = 4/126 (3%) Query: 36 MLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IE 94 ++ +R + + DK VLD G G + + G+++S + ++ Sbjct: 1 GMKTIIRQPQLYRFLKYCNESNLDKTVLDCGAGGDLPPLSIFVEDGYKTYGIEISDLQLK 60 Query: 95 MAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHY 154 A+ N F K+ + +G + + + + S + + ++ + + Sbjct: 61 KAENFSRENNF--KLNISKGDIRKLPFKDESMSFVYSYGTIFHM-RKNDVKEAIDEIKRV 117 Query: 155 LVEGGL 160 L GGL Sbjct: 118 LKPGGL 123 >4KRI-A nrPDB Length = 433 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 34/219 (15%), Positives = 73/219 (33%), Gaps = 16/219 (7%) Query: 43 TLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVE 101 + + + + +LD+G G G + AA V GVD+S+ ++ +A E V Sbjct: 207 WNQNLAILKRFGPMKTGQRMLDIGVGIGGGARQAASEFGLQVHGVDLSTNMLAVALERVH 266 Query: 102 LNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLI 161 ++T + D + S + + D + L GG + Sbjct: 267 KEK-DARVTYAVCDACEYEFEPNSFDYVFSR---DCIQHIKDTDKLFSRIYRALKPGGKV 322 Query: 162 FPDKCSI-HLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSD 220 + H E + + Y Y + + +D +E N+ Sbjct: 323 LITMYGVGHGTLSESFKEYVSQRQY----YLKNLEQIEEIAKKTGFID-IEVENMTPRFK 377 Query: 221 KLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFD 259 +++ + ++ F + F A +G+V+ + Sbjct: 378 EILLEERERIEQDKETFLAKFSQNAY-----DGLVSGWK 411 >4KDC-A nrPDB Length = 246 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 10/107 (9%) Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITL--LRGKL 116 K VLDVGCG GIL+ A+ GA V G+D + ++ +L+ I + ++ + Sbjct: 63 GKKVLDVGCGGGILAESMAREGAT-VTGLD---MGFEPLQVAKLHALESGIQVDYVQETV 118 Query: 117 EDVHLP-FPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 E+ + D++ M L + +V+ A + GG +F Sbjct: 119 EEHAAKHAGQYDVVTCMEM---LEHVPDPQSVVRACAQLVKPGGDVF 162 >1JG3-A nrPDB Length = 235 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 50/131 (38%), Gaps = 5/131 (3%) Query: 2 SKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDT-VRTLSYRNAIIQNKDLFKDK 60 SK + + + + E Y Y H + V +++ +L Sbjct: 36 SKEVER-AFLKYPRYLSVEDKY-KKYAHIDEPLPIPAGQTVSAPHMVAIMLEIANLKPGM 93 Query: 61 IVLDVGCGTGILSMFAAKHGAKHVIGVD-MSSIIEMAKELVELNGFSDKITLLRGKLEDV 119 +L+VG G+G + ++ V ++ + ++E AK +E G + + ++ G Sbjct: 94 NILEVGTGSGWNAALISEIVKTDVYTIERIPELVEFAKRNLERAGVKN-VHVILGDGSKG 152 Query: 120 HLPFPKVDIII 130 P D+II Sbjct: 153 FPPKAPYDVII 163 >3EGE-A nrPDB Length = 261 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 50/126 (39%), Gaps = 12/126 (9%) Query: 39 DTVRTLSYR--NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMA 96 R R NAII +L K ++ D+G GTG S+ A G V V+ S ++ Sbjct: 13 SQTRVPDIRIVNAIINLLNLPKGSVIADIGAGTGGYSVALANQGL-FVYAVEPSIVMRQQ 71 Query: 97 KELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLV 156 + ++ G E++ LP VD +IS + + ++ + Sbjct: 72 AVV------HPQVEWFTGYAENLALPDKSVDGVISILAIHHFSH---LEKSFQEMQRIIR 122 Query: 157 EGGLIF 162 +G ++ Sbjct: 123 DGTIVL 128 >1VQ1-A nrPDB Length = 294 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 24/77 (31%), Positives = 41/77 (53%), Gaps = 2/77 (2%) Query: 60 KIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSII-EMAKELVELNGFSDKITLLRGK-LE 117 K V D+G G+G + + AK V D+SS E+A++ E +G SD+ + +G+ LE Sbjct: 135 KTVADIGTGSGAIGVSVAKFSDAIVFATDVSSKAVEIARKNAERHGVSDRFFVRKGEFLE 194 Query: 118 DVHLPFPKVDIIISEWM 134 F +++I+S Sbjct: 195 PFKEKFASIEMILSNPP 211 >2O57-A nrPDB Length = 297 Score = 45.5 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 38/171 (22%), Positives = 67/171 (39%), Gaps = 21/171 (12%) Query: 6 VKDSATEKTKLSESEQHYFNSYD----HYGIHEEML-QDTVRTLSYRN------AIIQNK 54 VKD+A +S++ YF+ + H G+++E + QD +R S R + Sbjct: 19 VKDNAEIYYDDDDSDRFYFHVWGGEDIHVGLYKEPVDQDEIREASLRTDEWLASELAMTG 78 Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVE----LNGFSDKIT 110 L + LD+G G G + F + K + +D +I + + E G +D IT Sbjct: 79 VLQRQAKGLDLGAGYGGAARFLVR---KFGVSIDCLNIAPVQNKRNEEYNNQAGLADNIT 135 Query: 111 LLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLI 161 + G ++ D I S+ FL + L G++ Sbjct: 136 VKYGSFLEIPCEDNSYDFIWSQ--DAFLHSPDKLKVFQECA-RVLKPRGVM 183 >1RI1-A nrPDB Length = 298 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 37/173 (21%), Positives = 58/173 (33%), Gaps = 22/173 (12%) Query: 3 KTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVR--TLSYRNAIIQNKDLF--- 57 KT KD A E K E + I E + R T++ RNA K Sbjct: 8 KTFRKDQAMEGKKEEIREHYN-------SIRERGRESRQRSKTINIRNANNFIKACLIRL 60 Query: 58 ---KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRG 114 + VLD+GCG G + + G GVD++ + + V + + Sbjct: 61 YTKRGDSVLDLGCGKGGDLLKYERAGIGEYYGVDIAEVS-INDARVRARNMKRRFKVFFR 119 Query: 115 KLED----VHLPFPKVDIIISEW-MGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + + L D+I S++ Y +D +L GG Sbjct: 120 AQDSYGRHMDLGKE-FDVISSQFSFHYAFSTSESLDIAQRNIARHLRPGGYFI 171 >4KRG-A nrPDB Length = 466 Score = 45.2 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 34/150 (22%), Positives = 63/150 (42%), Gaps = 9/150 (6%) Query: 16 LSESEQHYFNSYDHY-GIHEEMLQDTVRTLSY--RNAIIQNKDLFKDKIVLDVGCGTGIL 72 +S + +++ Y + ML T + L R I+ + +K V+D+G G G Sbjct: 12 RRDSFKTFWDKYSDKPDTNSMMLNQTAQDLEASDRADILSSLPHLTNKDVVDIGAGIGRF 71 Query: 73 SMFAAKHGAKHVIGVDMSSIIEMAKE-LVELNGFSDKITLLRGKLEDVHLPFPKVDIIIS 131 + A+ A+ V+ D IE E E N I+ G + + VD++ + Sbjct: 72 TTVLAET-ARWVLSTD---FIESFIEKNQERNAHMGNISYQIGDAVHLQMDEKSVDLVFT 127 Query: 132 EWMGYFLLYESMMDTVLYARDHYLVEGGLI 161 W+ +L +++ +L A +L G I Sbjct: 128 NWLMMYLSDREVIEFLLNAM-RWLRADGYI 156 >3L8D-A nrPDB Length = 242 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 35/168 (20%), Positives = 63/168 (37%), Gaps = 27/168 (16%) Query: 33 HEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI 92 +EM R+ + + K+ VLDVGCG G + ++ G K V GVD+S Sbjct: 31 SQEMWDSGSRSTI---IPFFEQYVKKEAEVLDVGCGDGYGTYKLSRTGYKAV-GVDIS-- 84 Query: 93 IEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIIS----EWMGYFLLYESMMDTVL 148 E+ + + G ++ ++G L + + + I++ EW L ++ + Sbjct: 85 -EVMIQKGKERGEGPDLSFIKGDLSSLPFENEQFEAIMAINSLEWTEEPL---RALNEI- 139 Query: 149 YARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSP 196 L G I + G + N + +YG D Sbjct: 140 ---KRVLKSDGY-----ACIAILGPTAK----PRENSYPRLYGKDVVC 175 >4MWZ-A nrPDB Length = 267 Score = 44.4 bits (103), Expect = 7e-05, Method: Composition-based stats. Identities = 34/141 (24%), Positives = 53/141 (37%), Gaps = 11/141 (7%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSD-K 108 I+ + L + VLD+G G G + + HV GVD I E + +L K Sbjct: 47 ILSDIQLDANSKVLDIGSGLGGGCKYINEKYGAHVHGVD---ICEKMVTIAKLRNQDKAK 103 Query: 109 ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLY--ESMMDTVLYARDHYLVEGG-LIFPDK 165 I + P D+I S L Y + M+ Y +L G L+ D Sbjct: 104 IEFEAKDILKKDFPESTFDMIYSRDSILHLSYADKKMLFEKCY---KWLKPNGILLITDY 160 Query: 166 CSIHLAGL-EDSQYKDEKLNY 185 C+ + E+ + +K Y Sbjct: 161 CADKIENWDEEFKAYIKKRKY 181 >6MRO-A nrPDB Length = 194 Score = 44.4 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 25/117 (21%), Positives = 53/117 (45%), Gaps = 6/117 (5%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSD 107 A+I++ ++ + LD+GCG G ++ AK+G V G+D++ ++ + Sbjct: 23 QALIESGEIRPGRA-LDIGCGRGENAIMLAKNGCD-VTGIDLAKRA-ISDAKAKAIERHV 79 Query: 108 KITLLRGKLEDVH--LPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 K+ + G + ++ + DI+I + + + E + + L EGG F Sbjct: 80 KVNFIVGNVLEMDQLFTEDEFDIVIDSGLFHVITDEERLLFTRHVH-KVLKEGGKYF 135 >1UWV-A nrPDB Length = 433 Score = 44.0 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 44/89 (49%), Gaps = 13/89 (14%) Query: 31 GIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVD-M 89 G++++M+ + L D+ + VLD+ CG G ++ A A V+GV+ + Sbjct: 269 GVNQKMVARALEWL----------DVQPEDRVLDLFCGMGNFTLPLATQAAS-VVGVEGV 317 Query: 90 SSIIEMAKELVELNGFSDKITLLRGKLED 118 +++E ++ LNG + +T LE+ Sbjct: 318 PALVEKGQQNARLNGLQN-VTFYHENLEE 345 >1NKV-A nrPDB Length = 256 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 29/126 (23%), Positives = 51/126 (40%), Gaps = 15/126 (11%) Query: 43 TLSYRNAIIQNKDLFKDKIVLDVGCGTG-ILSMFAAKHGAKHVIGVDMSS-IIEMAKELV 100 T + + + +LD+G G+G +L +A HG G+DMSS AK Sbjct: 21 TEEKYATLGRVLRMKPGTRILDLGSGSGEMLCTWARDHGITG-TGIDMSSLFTAQAKRRA 79 Query: 101 ELNGFSDKITLLRGKLEDVHLPFPKVDI---IISEW-MGYFLLYESMMDTVLYARDHYLV 156 E G S+++ + ++ K D+ + + W G F E ++ L Sbjct: 80 EELGVSERVHFIHNDAAG-YVANEKCDVAACVGATWIAGGFAGAEELLAQS-------LK 131 Query: 157 EGGLIF 162 GG++ Sbjct: 132 PGGIML 137 >4NEC-A nrPDB Length = 264 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 47/127 (37%), Gaps = 13/127 (10%) Query: 51 IQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKI 109 ++ L + VLD GCGTG ++ A G V G+D+S I +A++ + G Sbjct: 53 LEKAGLIQGA-VLDAGCGTGEDALHLAGLGYA-VTGLDLSPTAISVARDKADARGLGAVF 110 Query: 110 TLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIH 169 + D+ + D +I + + + + A G + H Sbjct: 111 EV--ADALDLTGWEERFDTVIDSGLAHTFEGDR-LRAYATALHRACRPGAVA-------H 160 Query: 170 LAGLEDS 176 + + D Sbjct: 161 ILSISDR 167 >5H02-A nrPDB Length = 283 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 46/250 (18%), Positives = 81/250 (32%), Gaps = 8/250 (3%) Query: 7 KDSATEKTKLSESEQHYFNSY--DHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLD 64 K + Y N Y +E++ R S + II K VLD Sbjct: 26 KQDFGDNPIEVRESDGYTNEYVSGFVDKWDELIDWESRAESEGDTIINILKERGVKKVLD 85 Query: 65 VGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFP 124 V GTG S+ + G V + ++ A + +G+ + + + + Sbjct: 86 VATGTGFNSVRLLQAGFDVVSADGSAEMLVKAFDNARDHGYLMRTVQADWRWMNKDI-HD 144 Query: 125 KVDIIISEWMG-YFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLED---SQYKD 180 K D I+ L E L L G++ D+ + + A L+D S++ Sbjct: 145 KFDAIVCLGNSFTHLFDEGDRRKALAEFYALLKHDGVLLLDQRN-YDAILDDGYSSKHAH 203 Query: 181 EKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSN 240 VY + +E +V N+ L+ V ++ + Sbjct: 204 YYCGDTVSVYPEHVDEGLARFKYEFSDGSVYNLNMFPLRKDYTRQLLHEVGFQEINTLGD 263 Query: 241 FKLTAKRQDM 250 FK T K + Sbjct: 264 FKETYKEDEP 273 >3V8V-A nrPDB Length = 702 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 35/155 (22%), Positives = 58/155 (37%), Gaps = 14/155 (9%) Query: 3 KTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIV 62 K K E T+ + Y G+ + +R A + K K Sbjct: 493 KLGEKGEFLEVTEYNAHLWVNLTDYLDTGLFLD----------HRIARRMLGQMSKGKDF 542 Query: 63 LDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKIT-LLRGK-LEDV 119 L++ TG ++ A GA+ VDMS +E A+ + LNG + + L++ L + Sbjct: 543 LNLFSYTGSATVHAGLGGARSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLIQADCLAWL 602 Query: 120 HLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHY 154 + D+I + F + M D RDH Sbjct: 603 REANEQFDLIFIDPP-TFSNSKRMEDAFDVQRDHL 636 >3DMF-A nrPDB Length = 381 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 25/109 (22%), Positives = 49/109 (44%), Gaps = 8/109 (7%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKE-LVELNGFSDKITLLRGKL 116 + + VLD+G G G L++ A+ GA V+GV+ ++ + +E N K L + Sbjct: 233 RGRQVLDLGAGYGALTLPLARMGA-EVVGVEDDLASVLSLQKGLEANAL--KAQALHSDV 289 Query: 117 EDVHLPFPKVDIIISEWMGYFLLYESMMD---TVLYARDHYLVEGGLIF 162 ++ + DII++ + + ++D + L GG+ F Sbjct: 290 DEALTEEARFDIIVTNPP-FHVGGAVILDVAQAFVNVAAARLRPGGVFF 337 >2YXD-A nrPDB Length = 183 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 25/79 (31%), Positives = 41/79 (51%), Gaps = 7/79 (8%) Query: 44 LSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELN 103 R I +L KD +V+DVGCG+G +++ AK K V +D ++ A E+ + N Sbjct: 21 EEIRAVSIGKLNLNKDDVVVDVGCGSGGMTVEIAKR-CKFVYAID---YLDGAIEVTKQN 76 Query: 104 GFSDKIT---LLRGKLEDV 119 I +++G+ EDV Sbjct: 77 LAKFNIKNCQIIKGRAEDV 95 >5FAD-A nrPDB Length = 161 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 28/122 (22%), Positives = 57/122 (46%), Gaps = 12/122 (9%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAK-HGAKHVIGVDMSS-IIEMAKELVELNGFSD 107 +++ + +D IV D+GCG G + + AAK K +GV+++ I A +E NG + Sbjct: 20 MLEIAKVSQDDIVYDLGCGDGRIIITAAKDFNVKKAVGVEINDERIREALANIEKNGVTG 79 Query: 108 KITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYAR-DHYLVEGGLIFPDKC 166 + ++++G +V ISE + + ++ +L + + L G + + Sbjct: 80 RASIVKGNFFEVD---------ISEATVVTMFLLTNVNEMLKPKLEKELKPGTRVVSHEF 130 Query: 167 SI 168 I Sbjct: 131 EI 132 >2PJD-A nrPDB Length = 343 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 29/119 (24%), Positives = 48/119 (40%), Gaps = 12/119 (10%) Query: 56 LFKDKIVLDVGCGTGILSMFAAKHGAK-HVIGVDMS-SIIEMAKELVELNGFSDKITLLR 113 K K VLDVGCG G+LS+ A+H K + D+S +E ++ + NG ++ Sbjct: 195 HTKGK-VLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATLAANGVEGEV-FAS 252 Query: 114 GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAG 172 +V + D+IIS ++ M T L A + + + Sbjct: 253 NVFSEVK---GRFDMIISNPP----FHDGM-QTSLDAAQTLIRGAVRHLNSGGELRIVA 303 >5BXY-A nrPDB Length = 158 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 17/69 (24%), Positives = 41/69 (59%), Gaps = 3/69 (4%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAK-HGAKHVIGVDM-SSIIEMAKELVELNGFSD 107 +++ D+ + ++ D+G G G + + AA+ HGA+ V G+++ +++ A++ + G +D Sbjct: 16 MLELADVDETDVLYDLGSGDGRIVIRAARTHGARGV-GIEIDPDLVKKARKNAKEAGVAD 74 Query: 108 KITLLRGKL 116 + +G L Sbjct: 75 LVEFRQGDL 83 >6GKZ-A nrPDB Length = 351 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 56/166 (33%), Gaps = 8/166 (4%) Query: 56 LFKDKIVLDVGCGTGILSMFAAKHGAK-HVIGVDMS-SIIEMAKELVELNGFSDKITLLR 113 + + VLD+GCG G L++ A+ V V S S E +E + + + Sbjct: 121 IQDGQSVLDLGCGQGALTLHVAQKYKNCRVTAVTNSVSQKEYIEEESRRRNLLN-VEVKL 179 Query: 114 GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGL 173 + + I++ E + YE ++ + ++ + GL+F + Sbjct: 180 ADITTHEMAETYDRILVIELFEHMKNYELLLRKI----SEWISKDGLLFLEHICHKTFAY 235 Query: 174 EDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTS 219 D+ + + V+ D V N T S Sbjct: 236 HYEPLDDDD-WFTEYVFPAGTMIIPSASFFLYFQDDVSVVNHWTLS 280 >4INE-A nrPDB Length = 454 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 31/202 (15%), Positives = 69/202 (34%), Gaps = 9/202 (4%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFS 106 I + D + +LD+G G G + A HV G+D+SS ++ +A E + Sbjct: 231 KIIKRFGDFKPGQTMLDIGVGIGGGARQVADEFGVHVHGIDLSSNMLAIALERLHEEK-D 289 Query: 107 DKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKC 166 ++ D + S + + + + L GG + Sbjct: 290 SRVKYSITDALVYQFEDNSFDYVFSR---DCIQHIPDTEKLFSRIYKALKPGGKVL---I 343 Query: 167 SIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFD 226 +++ G + K K Q Y + + ++ V+ N+ +++ + Sbjct: 344 TMYGKGYGEQSDK-FKTYVAQRAYFLKNLKEIADIANKTGFVNVQTENMTPRFKEILLEE 402 Query: 227 LNTVKISDLAFKSNFKLTAKRQ 248 ++ ++ F S F + Sbjct: 403 RGHLEQNEAEFMSKFTQRERDS 424 >4FS8-A nrPDB Length = 383 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 33/124 (26%), Positives = 57/124 (45%), Gaps = 23/124 (18%) Query: 57 FKDKIVLDVGCGTG----ILSMFAAKHGAKHVIGVDMSSI-IEMAKELVEL-------NG 104 + VLD+GCGTG + S +HG VIGVDM +E+A++ VE + Sbjct: 82 LEGATVLDLGCGTGRDVYLASKLVGEHG--KVIGVDMLDNQLEVARKYVEYHAEKFFGSP 139 Query: 105 FSDKITLLRGKLEDVH------LPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEG 158 + L+G +E++ +P VDI+IS + + + ++ L +G Sbjct: 140 SRSNVRFLKGFIENLATAEPEGVPDSSVDIVISNCVCNLSTNKLALFKEIH---RVLRDG 196 Query: 159 GLIF 162 G ++ Sbjct: 197 GELY 200 >2VS1-A nrPDB Length = 425 Score = 42.1 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 33/163 (20%), Positives = 66/163 (40%), Gaps = 16/163 (9%) Query: 42 RTLSYRNA--IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSII-EMAKE 98 +T SY+ + + +L + + +LD+ G G ++ AK G V G D + EMA+ Sbjct: 272 QTNSYQAVNLVRKVSELVEGEKILDMYSGVGTFGIYLAKRGFN-VKGFDSNEFAIEMARR 330 Query: 99 LVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEG 158 VE+N + + + + D +I + + + L R + G Sbjct: 331 NVEINNVDAEFEVASDR----EVSVKGFDTVIVDPP------RAGLHPRLVKRLNREKPG 380 Query: 159 GLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLV 201 +++ A D + D +++ + F ++P V LV Sbjct: 381 VIVYVSCNPETFA--RDVKMLDYRIDEIVALDMFPHTPHVELV 421 >3CCF-A nrPDB Length = 279 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 24/87 (27%), Positives = 41/87 (47%), Gaps = 8/87 (9%) Query: 20 EQHYFNSYDHYGIHEEMLQDTVRTLS------YRNAIIQNKDLFKDKIVLDVGCGTGILS 73 E YF + G + T+ Y ++Q + + +LD+GCGTG L+ Sbjct: 13 ENLYFQGMTNLGTAKNFWDATLYQDKHSFVWQYGEDLLQLLNPQPGEFILDLGCGTGQLT 72 Query: 74 MFAAKHGAKHVIGVD-MSSIIEMAKEL 99 A+ GA V+G D +++IE A++ Sbjct: 73 EKIAQSGA-EVLGTDNAATMIEKARQN 98 >5BP7-A nrPDB Length = 271 Score = 41.7 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 28/104 (26%), Positives = 41/104 (39%), Gaps = 8/104 (7%) Query: 19 SEQHYFNSYDHYGIHEEMLQDTVR-----TLSYRNAIIQNKDLFKDKIVLDVGCGTG-IL 72 +E YF S + + R T + L VLD+G G+G +L Sbjct: 15 TENLYFQSMLDIPRIFTITESAHRIHNPITPEKLTTLGAALRLEPGTRVLDLGSGSGEML 74 Query: 73 SMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGK 115 +A HG G+DMS AK E G +D++T + G Sbjct: 75 CTWARDHGIIG-TGIDMSQLFTAQAKLRAEELGVADRVTFIHGD 117 >3SM3-A nrPDB Length = 235 Score = 41.7 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 40/114 (35%), Gaps = 6/114 (5%) Query: 54 KDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGF----SDK 108 L +D +LD+GCG+G +S+ A G V G+D+ S I +A+ G K Sbjct: 26 NYLQEDDEILDIGCGSGKISLELASKGYS-VTGIDINSEAIRLAETAARSPGLNQKTGGK 84 Query: 109 ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + D + + + ++ L G ++ Sbjct: 85 AEFKVENASSLSFHDSSFDFAVMQAFLTSVPDPKERSRIIKEVFRVLKPGAYLY 138 >2GLU-A nrPDB Length = 239 Score = 41.7 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 42/105 (40%), Gaps = 6/105 (5%) Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFSDKITLLRGKLE 117 + VLD+G G G ++ A + IGVD ++E+A + G + + +G E Sbjct: 22 EHRVLDIGAGAGHTAL-AFSPYVQECIGVDATKEMVEVASSFAQEKGVEN-VRFQQGTAE 79 Query: 118 DVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + P DII + + + S + + L + G Sbjct: 80 SLPFPDDSFDIITCRYAAH---HFSDVRKAVREVARVLKQDGRFL 121 >3LGA-A nrPDB Length = 253 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 61/171 (35%), Gaps = 19/171 (11%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG--AKHVIGVDM-SSIIEMAKELVELNG 104 I+ + +++ G G+G L++F A V+ ++ ++A E ++ G Sbjct: 83 ALIVAYAGISPGDFIVEAGVGSGALTLFLANIVGPEGRVVSYEIREDFAKLAWENIKWAG 142 Query: 105 FSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPD 164 F D++T+ + + + VD +I + + V+ L GG Sbjct: 143 FDDRVTIKLKDIYE-GIEEENVDHVILDLPQP--------ERVVEHAAKALKPGGFFVAY 193 Query: 165 KCSIHLAGLEDSQYK-DEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNN 214 + + EKL ++D + + V + E + + Sbjct: 194 T------PCSNQVMRLHEKLREFKDYFMKPRTINVLVFDQEVKKECMRPRT 238 >2ESR-A nrPDB Length = 177 Score = 40.9 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 18/98 (18%), Positives = 41/98 (41%), Gaps = 3/98 (3%) Query: 40 TVRTLSYRNAII-QNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIE-MAK 97 + R AI F VLD+ G+G L++ A G + V+ + + + + Sbjct: 12 RPTSDKVRGAIFNMIGPYFNGGRVLDLFAGSGGLAIEAVSRGMSAAVLVEKNRKAQAIIQ 71 Query: 98 ELVELNGFSDKITLLRGKLED-VHLPFPKVDIIISEWM 134 + + + ++ TLL+ + E + + D++ + Sbjct: 72 DNIIMTKAENRFTLLKMEAERAIDCLTGRFDLVFLDPP 109 >2R3S-A nrPDB Length = 335 Score = 40.9 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 35/71 (49%), Gaps = 2/71 (2%) Query: 61 IVLDVGCGTGILSMFAAKHGA-KHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDV 119 VLD+ G+ + A+H + GVD +S++E+AKE + G + + + G +V Sbjct: 168 KVLDISASHGLFGIAVAQHNPNAEIFGVDWASVLEVAKENARIQGVASRYHTIAGSAFEV 227 Query: 120 HLPFPKVDIII 130 D+++ Sbjct: 228 DYGND-YDLVL 237 >3GU3-A nrPDB Length = 284 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 29/116 (25%), Positives = 47/116 (40%), Gaps = 9/116 (7%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA--KHVIGVDMSS-IIEMAKELVELNGFS 106 + + K ++D GCG G L + G+D ++ A+EL L + Sbjct: 14 VNTVWKITKPVHIVDYGCGYGYLGLVLMPLLPEGSKYTGIDSGETLLAEARELFRLLPYD 73 Query: 107 DKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 L G ++ L K DI I FLL+ + +T+L H + +GG I Sbjct: 74 S--EFLEGDATEIEL-NDKYDIAICH---AFLLHMTTPETMLQKMIHSVKKGGKII 123 >5YAC-A nrPDB Length = 346 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 21/80 (26%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKL 116 + ++V D+ G G S+ AK A+ V D++ I+ +E ++LN ++ + +L G Sbjct: 198 EGEVVFDMFAGVGPFSILLAKK-AELVFACDINPWAIKYLEENIKLNKVNNVVPIL-GDS 255 Query: 117 EDVHLPFPKVDIIISEWMGY 136 ++ + K D II Y Sbjct: 256 REIEV---KADRIIMNLPKY 272 >4LG1-A nrPDB Length = 224 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 43/99 (43%), Gaps = 11/99 (11%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITL-LR 113 + VL++G GTG + + AA GA V+ D+ + ++ K + +N +T ++ Sbjct: 59 HALSRRSVLELGSGTGAVGLMAATLGAD-VVVTDLEELQDLLKMNINMNK--HLVTGSVQ 115 Query: 114 GKLEDVHLPFPKV----DIIISEWMGYFLLYESMMDTVL 148 K+ D I+ M + YE ++ +L Sbjct: 116 AKVLKWGEEIEGFPSPPDFIL---MADCIYYEESLEPLL 151 >5U19-A nrPDB Length = 341 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 26/114 (22%), Positives = 51/114 (44%), Gaps = 16/114 (14%) Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIE-MAKELVELNGFSDKITLLRGKLE 117 LD+GCG+G+LS+ A V+GVD++ +++ LNG ++ +T G + Sbjct: 144 GARALDMGCGSGVLSLVLADRYES-VLGVDVNPRAVALSRLNAALNGLTN-VTFREGDMF 201 Query: 118 DVHLPFP-KVDIII---------SEWMGYFLLYESMMDTVLYARDHYLVEGGLI 161 + P + I+ +E++ E +++T L GG++ Sbjct: 202 E---PAEGRFSRIVFNSPTNEEGNEFVDLLEAGEPILETFFRNVPRKLESGGIV 252 >4QPN-A nrPDB Length = 227 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 8/109 (7%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELN---GFSDKITLLR 113 F+ K V+++G GTGI+ + AA G V D+ +E + V+ N G ++ L Sbjct: 75 FRGKKVIELGAGTGIVGILAALQGGD-VTITDLPLALEQIQGNVQANVPAGGQAQVRALS 133 Query: 114 GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 ++ P D+++ + Y E +L H G I+ Sbjct: 134 WGIDHHVFPA-NYDLVLGADIVYL---EPTFPLLLGTLQHLCRPHGTIY 178 >1XDU-A nrPDB Length = 374 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 25/102 (24%), Positives = 43/102 (42%), Gaps = 4/102 (3%) Query: 62 VLDVGCGTGI-LSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVH 120 VLDVG G G L+ A + V+++ E A+ G +D++T+ G Sbjct: 186 VLDVGGGNGGMLAAIALRAPHLRGTLVELAGPAERARRRFADAGLADRVTVAEGDFFK-P 244 Query: 121 LPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 LP D+++ ++ E + T+L L GG + Sbjct: 245 LPVT-ADVVLLSFVLLNWSDEDAL-TILRGCVRALEPGGRLL 284 >4O29-A nrPDB Length = 208 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 40/108 (37%), Gaps = 12/108 (11%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKH--VIGVD-MSSIIEMAKELVELNGFSDKITLLRG 114 +L+VG G+G + A+ K + ++ + + A + +E G+ + + G Sbjct: 75 PGMKILEVGTGSGYHAAVCAEAIEKKGRIYTIEIVKELAVFAAQNLERLGYWGVVEVYHG 134 Query: 115 KLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + D II + D + A L +GG++ Sbjct: 135 DGKKGLEKHAPFDAIIVT---------AAADVIPPALIRQLKDGGVMV 173 >4AZW-A nrPDB Length = 471 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 32/137 (23%), Positives = 55/137 (40%), Gaps = 11/137 (8%) Query: 27 YDHYGIHEEMLQDTVRTLSYRNAIIQ------NKDLFKDKIVLDVGCGTGILSMFAAKHG 80 Y H E D R + R +I ++ L + VLD+GC G S+ A G Sbjct: 29 YQTIFGHPEWDGDAARDCNQRLDLITEQYDNLSRALGRPLNVLDLGCAQGFFSLSLASKG 88 Query: 81 AKHVIGVD-MSSIIEMAKELVELNGFSDKITLLRGKLEDV--HLPFPKVDIIISEWMGYF 137 A ++G+D I + + L E N G++E+V L + D+ I + + Sbjct: 89 AT-IVGIDFQQENINVCRALAEEN-PDFAAEFRVGRIEEVIAALEEGEFDLAIGLSVFHH 146 Query: 138 LLYESMMDTVLYARDHY 154 +++ +D V Sbjct: 147 IVHLHGIDEVKRLLSRL 163 >3GDH-A nrPDB Length = 241 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 2/65 (3%) Query: 52 QNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKELVELNGFSDKIT 110 + FK +V+D CG G ++ A G + VI +D+ + I +A+ E+ G +DKI Sbjct: 72 RVSQSFKCDVVVDAFCGVGGNTIQFALTGMR-VIAIDIDPVKIALARNNAEVYGIADKIE 130 Query: 111 LLRGK 115 + G Sbjct: 131 FICGD 135 >3EGI-A nrPDB Length = 206 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 2/65 (3%) Query: 52 QNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKELVELNGFSDKIT 110 + FK +V+D CG G ++ A G + VI +D+ + I +A+ E+ G +DKI Sbjct: 37 RVSQSFKCDVVVDAFCGVGGNTIQFALTGMR-VIAIDIDPVKIALARNNAEVYGIADKIE 95 Query: 111 LLRGK 115 + G Sbjct: 96 FICGD 100 >4AZV-A nrPDB Length = 569 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 32/137 (23%), Positives = 55/137 (40%), Gaps = 11/137 (8%) Query: 27 YDHYGIHEEMLQDTVRTLSYRNAIIQ------NKDLFKDKIVLDVGCGTGILSMFAAKHG 80 Y H E D R + R +I ++ L + VLD+GC G S+ A G Sbjct: 29 YQTIFGHPEWDGDAARDCNQRLDLITEQYDNLSRALGRPLNVLDLGCAQGFFSLSLASKG 88 Query: 81 AKHVIGVD-MSSIIEMAKELVELNGFSDKITLLRGKLEDV--HLPFPKVDIIISEWMGYF 137 A ++G+D I + + L E N G++E+V L + D+ I + + Sbjct: 89 AT-IVGIDFQQENINVCRALAEEN-PDFAAEFRVGRIEEVIAALEEGEFDLAIGLSVFHH 146 Query: 138 LLYESMMDTVLYARDHY 154 +++ +D V Sbjct: 147 IVHLHGIDEVKRLLSRL 163 >4HTF-A nrPDB Length = 285 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 14/115 (12%) Query: 61 IVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKLEDV 119 VLD G G G ++ A+ G VI D+S+ +I+ AK+ E G SD + + +DV Sbjct: 71 RVLDAGGGEGQTAIKMAERG-HQVILCDLSAQMIDRAKQAAEAKGVSDNMQFIHCAAQDV 129 Query: 120 HLPFP-KVDII----ISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIH 169 VD+I + EW+ +VL L GG++ + H Sbjct: 130 ASHLETPVDLILFHAVLEWVA-------DPRSVLQTLWSVLRPGGVLSLMFYNAH 177 >5EVJ-A nrPDB Length = 387 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 30/131 (22%), Positives = 51/131 (38%), Gaps = 19/131 (14%) Query: 53 NKDLFKDKIVLDVGCGTGILSMFAAKHGAKH--VIGVDMSS-----IIEMAKELVELN-G 104 + VLD+G G+G + AAK + V GVDM+ I A G Sbjct: 78 IPAGIEGLRVLDLGAGSGRDAYVAAKLVGEKGSVTGVDMTPAQLEVAISHADAYARDKLG 137 Query: 105 FS-DKITLLRGKLEDVH---LPFPKVDIIISEWMGYFLLYESMMDT-VLYARDHYLVEGG 159 + +T ++G++E + L D++IS ++ S VL L GG Sbjct: 138 YGKSNMTFIQGEIEYLDRAGLEDSSFDLVIS----NCVINLSPDKARVLSEAYRVLAPGG 193 Query: 160 LIFPDKCSIHL 170 + +++ Sbjct: 194 EM--HFSDVYV 202 >5I2H-A nrPDB Length = 364 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 50/122 (40%), Gaps = 11/122 (9%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHV-IGVDMSSIIEMAKELVELNGFSDK 108 I+++ +++LDV G+GI +M + I D ++++A EL E G D+ Sbjct: 188 ILKDNSGSSGRVLLDVAGGSGIYTMAVLQKYPTWRGIIFDRPEVLKIAAELAEQTGVRDR 247 Query: 109 ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSI 168 + L G + PFP D + + +L++ + + P+ + Sbjct: 248 LELHAGDM--WVDPFPPAD----DILLSNVLHDWDRPQC----ARLVAKATSGLPEGGRL 297 Query: 169 HL 170 + Sbjct: 298 LI 299 >3BKX-A nrPDB Length = 275 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 20/80 (25%), Positives = 37/80 (46%), Gaps = 9/80 (11%) Query: 42 RTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG--AKHVIGVDMSS-------I 92 R ++R AI + + + +L++GCG G LS A + HV G+D++S Sbjct: 27 RQTAHRLAIAEAWQVKPGEKILEIGCGQGDLSAVLADQVGSSGHVTGIDIASPDYGAPLT 86 Query: 93 IEMAKELVELNGFSDKITLL 112 + A + D++T+ Sbjct: 87 LGQAWNHLLAGPLGDRLTVH 106 >2IFT-A nrPDB Length = 201 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 45/105 (42%), Gaps = 7/105 (6%) Query: 63 LDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFSD-KITLLRG-KLEDV 119 LD G+G L A AK V +++ ++ K+ ++ S + ++ L+ + Sbjct: 58 LDGFAGSGSLGFEALSRQAKKVTFLELDKTVANQLKKNLQTLKCSSEQAEVINQSSLDFL 117 Query: 120 HLPFPK--VDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 P + D++ + +F L E + L +++L LI+ Sbjct: 118 KQPQNQPHFDVVFLDPPFHFNLAEQAIS--LLCENNWLKPNALIY 160 >3GRV-A nrPDB Length = 295 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 5/84 (5%) Query: 52 QNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIE-MAKELVELNGFSDKIT 110 ++ +L KD +VL++G G GIL+ AK AK V +++ +E A +L EL I Sbjct: 44 ESANLTKDDVVLEIGLGKGILTEELAK-NAKKVYVIEIDKSLEPYANKLKELYN---NIE 99 Query: 111 LLRGKLEDVHLPFPKVDIIISEWM 134 ++ G V L + +++ Sbjct: 100 IIWGDALKVDLNKLDFNKVVANLP 123 >3FYD-A nrPDB Length = 263 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 5/84 (5%) Query: 52 QNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIE-MAKELVELNGFSDKIT 110 ++ +L KD +VL++G G GIL+ AK AK V +++ +E A +L EL I Sbjct: 15 ESANLTKDDVVLEIGLGKGILTEELAK-NAKKVYVIEIDKSLEPYANKLKELYN---NIE 70 Query: 111 LLRGKLEDVHLPFPKVDIIISEWM 134 ++ G V L + +++ Sbjct: 71 IIWGDALKVDLNKLDFNKVVANLP 94 >4F86-A nrPDB Length = 320 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 38/119 (31%), Gaps = 5/119 (4%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKELVELNGFSDK 108 + + ++D GCG G + A + V GV +S+ E G D Sbjct: 117 LDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDH 176 Query: 109 ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCS 167 + + + PF K + S W +Y + V +L GG Sbjct: 177 VRSRVCNM--LDTPFEKGTVAAS-WNNESSMY-VDLHDVFAEHSRFLRVGGRYVTVTGC 231 >2I6G-A nrPDB Length = 199 Score = 39.0 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 52/146 (35%), Gaps = 18/146 (12%) Query: 16 LSESEQHYF-NSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSM 74 ++ +++YF Y H ++L K + + LD+GCG G S+ Sbjct: 2 MTVRDENYFTEKYGLTRTHSDVLAAA-------------KVVAPGRT-LDLGCGNGRNSL 47 Query: 75 FAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWM 134 + A +G V D + E ++ D + L + D I+S + Sbjct: 48 YLAANGYD-VTAWDKNPASMANLERIKAAEGLDNLQTDLVDLNTLTFDGE-YDFILSTVV 105 Query: 135 GYFLLYESMMDTVLYARDHYLVEGGL 160 FL ++ + ++ GG Sbjct: 106 MMFLEAQT-IPGLIANMQRCTKPGGY 130 >5HJK-A nrPDB Length = 352 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 43/105 (40%), Gaps = 7/105 (6%) Query: 30 YGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM 89 + + ++ YR A + N + +L G + A+ V V++ Sbjct: 178 VDLSKVFFNPRMKGERYRIAQLVN----DGERILVPFAGVIPYPLVIARFKNVEVYAVEI 233 Query: 90 SSII-EMAKELVELN--GFSDKITLLRGKLEDVHLPFPKVDIIIS 131 + ++A+E +ELN KI ++ G + +V P D ++S Sbjct: 234 NEFAVKLAEENLELNRDRLKGKIKIIHGDVFEVLPNLPNFDRVVS 278 >3TMA-A nrPDB Length = 354 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 31/127 (24%), Positives = 49/127 (38%), Gaps = 9/127 (7%) Query: 43 TLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAA-KHGA-KHVIGVDMSSI-IEMAKEL 99 T A+++ D VLD G+G +++ AA G V D+ + +A+E Sbjct: 188 TPVLAQALLRLADARPGMRVLDPFTGSGTIALEAASTLGPTSPVYAGDLDEKRLGLAREA 247 Query: 100 VELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLY--ESMMD---TVLYARDHY 154 +G S I LR + FP+VD I++ L E + L Sbjct: 248 ALASGLS-WIRFLRADARHLPRFFPEVDRILANPPHGLRLGRKEGLFHLYWDFLRGALAL 306 Query: 155 LVEGGLI 161 L GG + Sbjct: 307 LPPGGRV 313 >2XVM-A nrPDB Length = 199 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 55/143 (38%), Gaps = 18/143 (12%) Query: 19 SEQHYF-NSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAA 77 +++YF + Y+ H E+L+ K + K LD+GCG G S++ A Sbjct: 6 RDENYFTDKYELTRTHSEVLE-------------AVKVVKPGKT-LDLGCGNGRNSLYLA 51 Query: 78 KHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYF 137 +G V D +++ E ++ D + L ++ + D I+S + F Sbjct: 52 ANGYD-VDAWDKNAMSIANVERIKSIENLDNLHTRVVDLNNLTF-DRQYDFILSTVVLMF 109 Query: 138 LLYESMMDTVLYARDHYLVEGGL 160 L + ++ GG Sbjct: 110 LE-AKTIPGLIANMQRCTKPGGY 131 >4QDJ-A nrPDB Length = 238 Score = 37.4 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 6/76 (7%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS--IIEMAKELVELNGFSDKITLLRG 114 +V D GCG G LS+ A+ GA V G D+S + E ++ E+ + ++ T + Sbjct: 61 LPGLLVCDAGCGVGSLSIPLAQAGA-LVYGSDISEKMVGEAQQKAQEVLAYGNQPTFMTQ 119 Query: 115 KLEDVHLPFPKVDIII 130 L + K D +I Sbjct: 120 DLAQL---GGKYDTVI 132 >3VC2-A nrPDB Length = 312 Score = 37.1 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 37/119 (31%), Gaps = 5/119 (4%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKELVELNGFSDK 108 + D ++D GCG G + A + V GV +S+ + D Sbjct: 109 MDHLGQAGPDDTLVDAGCGRGGSMVMAHRRFGSRVEGVTLSAAQADFGNRRARELRIDDH 168 Query: 109 ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCS 167 + + + PF K + S W +Y + + +L GG Sbjct: 169 VRSRVCNM--LDTPFDKGAVTAS-WNNESTMY-VDLHDLFSEHSRFLKVGGRYVTITGC 223 >1R74-A nrPDB Length = 294 Score = 37.1 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 32/79 (40%), Gaps = 2/79 (2%) Query: 21 QHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG 80 Y + + RT Y+ ++ + VLDV CGTG+ S+ + G Sbjct: 19 DQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEG 78 Query: 81 AKHVIGVDMSS-IIEMAKE 98 V VD S +++ A + Sbjct: 79 FS-VTSVDASDKMLKYALK 96 >2OXT-A nrPDB Length = 265 Score = 37.1 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 48/130 (36%), Gaps = 9/130 (6%) Query: 4 TAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVL 63 T K + +T E+ + G+ + + R + V+ Sbjct: 26 TRYKRAGVMETDRKEARDYLKRGDGKTGLSVSRGTAKLAWMEERGYVELTG------RVV 79 Query: 64 DVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVE-LNGFSDKITLLRGKLEDVHLP 122 D+GCG G S +AA HV+ V ++ E+ + I + +++ LP Sbjct: 80 DLGCGRGGWSYYAASR--PHVMDVRAYTLGVGGHEVPRITESYGWNIVKFKSRVDIHTLP 137 Query: 123 FPKVDIIISE 132 + D+I+ + Sbjct: 138 VERTDVIMCD 147 >2H1R-A nrPDB Length = 299 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 52/221 (23%), Positives = 80/221 (36%), Gaps = 41/221 (18%) Query: 19 SEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAK 78 E YF G H ++ + II + IVL++GCGTG L++ Sbjct: 14 RENLYFQ-----GQHL------LKNPGILDKIIYAAKIKSSDIVLEIGCGTGNLTVKLLP 62 Query: 79 HGAKHVIGVDM-SSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDII-------I 130 AK VI +D+ S +I K+ G+++ + + G P K D+ I Sbjct: 63 L-AKKVITIDIDSRMISEVKKRCLYEGYNN-LEVYEGDAIKTVFP--KFDVCTANIPYKI 118 Query: 131 SEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNY----- 185 S + + L+ + A + E LA + DS Y +N Sbjct: 119 SSPLIFKLISHRPLFKC--AVLMFQKE-------FAERMLANVGDSNYSRLTINVKLFCK 169 Query: 186 WQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFD 226 V + S F P P VD+V + S L FD Sbjct: 170 VTKVCNVNRSSFNP----PPKVDSVIVKLIPKESSFLTNFD 206 >1KP9-A nrPDB Length = 287 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 40/115 (34%), Gaps = 7/115 (6%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI-IEMAKELV-ELNGFSDKITLL 112 L +LDVGCG G M A + +V+G+ +S ++LV K LL Sbjct: 61 GLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVANSENLRSKRVLL 120 Query: 113 RGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCS 167 G VD I+S +E D L G++ + Sbjct: 121 AG----WEQFDEPVDRIVSIGAFEHFGHER-YDAFFSLAHRLLPADGVMLLHTIT 170 >1O54-A nrPDB Length = 277 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 30/188 (15%), Positives = 69/188 (36%), Gaps = 27/188 (14%) Query: 35 EMLQDTVRTLSYR----NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG--AKHVIGVD 88 E++ RT + I D+ + ++D G G+G + A+ + V + Sbjct: 85 EIMNMKRRTQIVYPKDSSFIAMMLDVKEGDRIIDTGVGSGAMCAVLARAVGSSGKVFAYE 144 Query: 89 M-SSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTV 147 ++A+ + G +++T+ K+ D+ F + D+ L+ + D Sbjct: 145 KREEFAKLAESNLTKWGLIERVTI---KVRDISEGFDEKDV--------DALFLDVPDPW 193 Query: 148 LYARDHY--LVEGGL---IFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVL 202 Y + L GG + P + + + ++ W+ + + P+ P+ Sbjct: 194 NYIDKCWEALKGGGRFATVCPTTNQVQETLKKLQELPFIRIEVWESL----FRPYKPVPE 249 Query: 203 HEPIVDTV 210 VD + Sbjct: 250 RLRPVDRM 257 >5KPG-A nrPDB Length = 397 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 29/145 (20%), Positives = 55/145 (37%), Gaps = 10/145 (6%) Query: 56 LFKDKIVLDVGCGTGILSMFAA-KHGAKHVIGVDMS-SIIEMAKELVELNGFSDKITLLR 113 + + +LD+GCG G L++ A K+ V G+ S S E + + S+ + ++ Sbjct: 166 IKDGQSILDLGCGHGSLTLHVAQKYRGCKVTGITNSVSQKEFIMDQCKKLDLSN-VEIIL 224 Query: 114 GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGL 173 + I + + YE + V ++ + GL+F + H + Sbjct: 225 EDVTKFETEITYDRIFAVALIEHMKNYELFLKKV----STWIAQDGLLFVEH---HCHKV 277 Query: 174 EDSQYKDEKLNYWQDVYGFDYSPFV 198 QY+ + W Y F V Sbjct: 278 FAYQYEPLDEDDWYTEYIFPSGTLV 302 >2QQH-A nrPDB Length = 334 Score = 36.7 bits (83), Expect = 0.014, Method: Composition-based stats. Identities = 31/131 (23%), Positives = 52/131 (39%), Gaps = 11/131 (8%) Query: 8 DSATEKTKLSESEQHYFNSYDHYGIHEEMLQDT-VRTLSYRNA---IIQNKDLFKDKIVL 63 DS +E+ + E+++ Y+ H E L DT + + Y NA + + K D + Sbjct: 61 DSTSERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLSKVKKDKSDSFGV 120 Query: 64 DVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPF 123 +G G + +GV S EL + N T + K++ H Sbjct: 121 TIGIGPAGSPLLVG-------VGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKM 173 Query: 124 PKVDIIISEWM 134 K DI++ E M Sbjct: 174 RKDDIMLDEGM 184 >1XCL-A nrPDB Length = 235 Score = 36.7 bits (83), Expect = 0.015, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 52/151 (34%), Gaps = 7/151 (4%) Query: 25 NSYDHYGIHEEMLQDTV--RTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAK 82 +YD H ++L V R + + + VL+VG G I + + K Sbjct: 24 AAYDTSDTHLQILGKPVMERWETPYMHSLAAAAASRGGRVLEVGFGMAIAASRVQQAPIK 83 Query: 83 HVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDV--HLPFPKVDIIISE--WMGYFL 138 ++ + + + L K+ L+G E+V LP D I+ + + Sbjct: 84 EHWIIECNDGVFQRLQNWALKQP-HKVVPLKGLWEEVAPTLPDGHFDGILYDTYPLSEET 142 Query: 139 LYESMMDTVLYARDHYLVEGGLIFPDKCSIH 169 + + + L GG++ + Sbjct: 143 WHTHQFNFIKTHAFRLLKPGGILTYCNLTSW 173 >4QNV-A nrPDB Length = 323 Score = 36.7 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 28/116 (24%), Positives = 46/116 (39%), Gaps = 5/116 (4%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVEL-NGFS 106 + DL + +LDVGCG+G GA +G+D + + E V G Sbjct: 113 RVLPHLSDLT-GRTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGND 171 Query: 107 DKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + LL +E + D + S MG S ++ + +D + EG L+ Sbjct: 172 QRAHLLPLGIEQLPA-LKAFDTVFS--MGVLYHRRSPLEHLWQLKDQLVNEGELVL 224 >3ELU-A nrPDB Length = 300 Score = 36.7 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 67/202 (33%), Gaps = 38/202 (18%) Query: 16 LSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMF 75 + + ++ GI +R + + L VLD+GCG G S + Sbjct: 45 RTAARRYLKEGRTDVGISVSRGAAKIRW------LHERGYLRITGRVLDLGCGRGGWSYY 98 Query: 76 AAKHGAKHVIGVDMSSI-IEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWM 134 AA K V+ V ++ IE ++ + + I + K +P D ++ Sbjct: 99 AA--AQKEVMSVKGYTLGIEGHEKPIHMQTLGWNIVKFKDKSNVFTMPTEPSDTLL---- 152 Query: 135 GYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDY 194 + ES + ++ RD + E W+ V ++ Sbjct: 153 --CDIGESSSNPLVE-RDRTMK----------------------VLENFERWKHVNTENF 187 Query: 195 SPFVPLVLHEPIVDTVERNNVN 216 V H +++ +ER + Sbjct: 188 CVKVLAPYHPDVIEKLERLQLR 209 >5M58-A nrPDB Length = 230 Score = 36.7 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 44/113 (38%), Gaps = 10/113 (8%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGAK-HVIGVDMS-SIIEMAKELVELNGFSDKITLL 112 + + V+D+ CG+G L + +++GVD+S ++ +A++ G + Sbjct: 36 GIADGQTVVDLCCGSGELEIILTSRFPSLNLVGVDLSEDMVRIARDYAAEQGKE--LEFR 93 Query: 113 RGKLED---VHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 G + + K D+++S + L + + GG I Sbjct: 94 HGDAQSPAGMEDLLGKADLVVSRHAFHRLTR---LPAGFDTMLRLVKPGGAIL 143 >3OJY-A nrPDB Length = 554 Score = 35.9 bits (81), Expect = 0.024, Method: Composition-based stats. Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 11/131 (8%) Query: 8 DSATEKTKLSESEQHYFNSYDHYGIHEEMLQDT-VRTLSYRNA---IIQNKDLFKDKIVL 63 DS E+ + E+++ Y+ H E L DT + + Y NA + + K D + Sbjct: 161 DSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLSKVKKDKSDSFGV 220 Query: 64 DVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPF 123 +G G + +GV S EL + N T + K++ H Sbjct: 221 TIGIGPAGSPLLVG-------VGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKM 273 Query: 124 PKVDIIISEWM 134 K DI++ E M Sbjct: 274 RKDDIMLDEGM 284 >6DCC-A nrPDB Length = 309 Score = 35.9 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 13/91 (14%) Query: 15 KLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQN--KDLFKDKIVLDVGCGTGIL 72 K + + Y N +YG R S + ++ + F+ + VLD+GC G L Sbjct: 27 KKQQRKFQYGNYCKYYGY---------RNPSCEDGRLRVLKPEWFRGRDVLDLGCNVGHL 77 Query: 73 SMFAA-KHGAKHVIGVDM-SSIIEMAKELVE 101 ++ A K G ++G+D+ S +I A++ + Sbjct: 78 TLSIACKWGPSRMVGLDIDSRLIHSARQNIR 108 >2RD7-A nrPDB Length = 367 Score = 35.9 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 11/131 (8%) Query: 8 DSATEKTKLSESEQHYFNSYDHYGIHEEMLQDT-VRTLSYRNA---IIQNKDLFKDKIVL 63 DS E+ + E+++ Y+ H E L DT + + Y NA + + K D + Sbjct: 66 DSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLSKVKKDKSDSFGV 125 Query: 64 DVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPF 123 +G G + +GV S EL + N T + K++ H Sbjct: 126 TIGIGPAGSPLLVG-------VGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKM 178 Query: 124 PKVDIIISEWM 134 K DI++ E M Sbjct: 179 RKDDIMLDEGM 189 >1D2C-A nrPDB Length = 292 Score = 35.9 bits (81), Expect = 0.028, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 31/79 (39%), Gaps = 2/79 (2%) Query: 21 QHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG 80 Y + + RT Y+ ++ VLDV CGTG+ S+ + G Sbjct: 19 DQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEG 78 Query: 81 AKHVIGVDMSS-IIEMAKE 98 V VD S +++ A + Sbjct: 79 FS-VTSVDASDKMLKYALK 96 >5MGZ-A nrPDB Length = 236 Score = 35.9 bits (81), Expect = 0.029, Method: Composition-based stats. Identities = 22/119 (18%), Positives = 50/119 (42%), Gaps = 16/119 (13%) Query: 55 DLFKDKIVLDVGCGTGILS-MFAAKHGAKHVIGVDMS-SIIEMAKELVELNGFSDKITLL 112 + + V+D+ CG+G L + +++ + +++GVD+S ++ +A+E G + + Sbjct: 36 GIADGQTVVDLCCGSGELEVILSSRFPSLNLVGVDLSEDMVRIAREYAAEQGKA--LEFR 93 Query: 113 RGK------LEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDK 165 G +ED+ K D+++S + L + GG + Sbjct: 94 HGDAQLLAGMEDL---AGKADLVVSRNAFHRLTR---LPAAFDTMLRLAKPGGAVLNCS 146 >1ZQ9-A nrPDB Length = 285 Score = 35.9 bits (81), Expect = 0.029, Method: Composition-based stats. Identities = 22/88 (25%), Positives = 42/88 (47%), Gaps = 4/88 (4%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFS 106 N+II L +VL+VG GTG +++ + AK V+ ++ ++ + V+ + Sbjct: 18 NSIIDKAALRPTDVVLEVGPGTGNMTVKLLEK-AKKVVACELDPRLVAELHKRVQGTPVA 76 Query: 107 DKITLLRGKLEDVHLPFPKVDIIISEWM 134 K+ +L G + LPF D ++ Sbjct: 77 SKLQVLVGDVLKTDLPF--FDTCVANLP 102 >3I9F-A nrPDB Length = 170 Score = 35.5 bits (80), Expect = 0.033, Method: Composition-based stats. Identities = 21/111 (18%), Positives = 40/111 (36%), Gaps = 14/111 (12%) Query: 54 KDLFKDK--IVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITL 111 ++F+ K +++D GCG G + + A + +D++ I + F ITL Sbjct: 11 PNIFEGKKGVIVDYGCGNGFYCKYLLEF-ATKLYCIDINVIALKEVK----EKFDSVITL 65 Query: 112 LRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + +P VD I+ V+ L + G + Sbjct: 66 ----SDPKEIPDNSVDFIL---FANSFHDMDDKQHVISEVKRILKDDGRVI 109 >6C5B-A nrPDB Length = 341 Score = 35.5 bits (80), Expect = 0.034, Method: Composition-based stats. Identities = 33/191 (17%), Positives = 65/191 (34%), Gaps = 25/191 (13%) Query: 13 KTKLSESEQHYFNSY-DHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKD-------KIVLD 64 +T + E+ + SY + H E D V + Q D K V+D Sbjct: 123 QTGETAFEKEFGTSYFGYLAKHPE--ADRVFNEAQAGYTKQVAHAVVDAYDFSPFKTVID 180 Query: 65 VGCGTGIL--SMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLP 122 +G G G L ++ ++ A+ ++ D + + A + + G D+ + G V +P Sbjct: 181 IGAGYGPLLSAILRSQPEARGIL-FDQPHVAQAAGKRLAEAGVGDRCGTVGGDFF-VEVP 238 Query: 123 FPKVDIIISEWMGYFLLYESMMDTVLYARD-HYLVEGGLIFPDKCSIHLAGLEDSQYKDE 181 D+ I + + R L P + + L + ++ Sbjct: 239 ADG-DVYILSLL---------LHDWDDQRSIEILRNCRRAMPAHGKLLIVELVLPEGEEP 288 Query: 182 KLNYWQDVYGF 192 W D++ Sbjct: 289 FFGKWLDLHML 299 >6M83-A nrPDB Length = 263 Score = 35.5 bits (80), Expect = 0.037, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 46/131 (35%), Gaps = 7/131 (5%) Query: 32 IHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS 91 +H+ +D R + A+++ + K +LDV CGTG +H A V+ Sbjct: 25 VHQGKGKDYHREAADLAALVR-RHSPKAASLLDVACGTG----MHLRHLADSFGTVEGLE 79 Query: 92 IIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYAR 151 + + + G + D L + L ++ +D L Sbjct: 80 LSADMLAIARRRNPDAVL--HHGDMRDFSLGRRFSAVTCMFSAIGHLAGQAELDAALERF 137 Query: 152 DHYLVEGGLIF 162 +++ G++ Sbjct: 138 AAHVLPDGVVV 148 >1VBF-A nrPDB Length = 231 Score = 35.5 bits (80), Expect = 0.038, Method: Composition-based stats. Identities = 34/167 (20%), Positives = 59/167 (35%), Gaps = 23/167 (13%) Query: 3 KTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEM-LQDTVRTLSYRNAIIQNK--DLFKD 59 KT A K S Y + HE + + + T + I DL K Sbjct: 12 KTQELAEAFNKVDRSLFLPENLKDYAYAHTHEALPILPGINTTALNLGIFMLDELDLHKG 71 Query: 60 KIVLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKELVELNGFSDKITLLRGKLE- 117 + VL++G G G + A+ V+ V+++ + A +L+ I L+ G Sbjct: 72 QKVLEIGTGIGYYTALIAEIV-DKVVSVEINEKMYNYASKLLSYYN---NIKLILGDGTL 127 Query: 118 --DVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + P+ +V + + YE L EGG++ Sbjct: 128 GYEEEKPYDRVVVWATAPTLLCKPYEQ------------LKEGGIMI 162 >5BP9-A nrPDB Length = 281 Score = 35.1 bits (79), Expect = 0.042, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 44/112 (39%), Gaps = 15/112 (13%) Query: 61 IVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSD--KITLLRGKLED 118 +LDVG G+G ++ A + K V +D+S + E+++L G D ++ L + Sbjct: 104 TILDVGAGSGCHAL-ALQESGKEVSAIDISPLS---VEVMKLRGVKDARQVNLFDERFA- 158 Query: 119 VHLPFPKVDIIISEWMGYFLLY--ESMMDTVLYARDHYLVEGGLIFPDKCSI 168 D I+ G ++ E+M L G I D + Sbjct: 159 -----ATFDTILMLMNGSGIIGRLENM-PLFFRKMKQLLRPDGCILMDSSDL 204 >3P9N-A nrPDB Length = 189 Score = 35.1 bits (79), Expect = 0.044, Method: Composition-based stats. Identities = 37/137 (27%), Positives = 62/137 (45%), Gaps = 12/137 (8%) Query: 37 LQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGV--DMSSIIE 94 D VR S N + +DL VLD+ G+G L + A GA V+ V D S Sbjct: 25 TTDRVR-ESLFNIVTARRDLT-GLAVLDLYAGSGALGLEALSRGAASVLFVESDQRSAAV 82 Query: 95 MAKELVELNGFSDKITLLRGKLEDVHLPF--PKVDIIISEWMGYFLLYESMMDTVLYAR- 151 +A+ +E G S TL RG + V VD+++++ Y + + +D +L A Sbjct: 83 IAR-NIEALGLS-GATLRRGAVAAVVAAGTTSPVDLVLADPP-YNVD-SADVDAILAALG 138 Query: 152 -DHYLVEGGLIFPDKCS 167 + + EG + ++ + Sbjct: 139 TNGWTREGTVAVVERAT 155 >1KR5-A nrPDB Length = 226 Score = 35.1 bits (79), Expect = 0.048, Method: Composition-based stats. Identities = 28/128 (21%), Positives = 49/128 (38%), Gaps = 11/128 (8%) Query: 39 DTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHG--AKHVIGVD-MSSIIEM 95 +Y ++ ++ L + LDVG G+GIL+ A+ VIG+D + +++ Sbjct: 59 SAPHMHAYALELLFDQ-LHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDD 117 Query: 96 AKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYES-MMDTVLYARDHY 154 + V D L G+ V L + +E Y ++ V A Sbjct: 118 SVNNVRK---DDPTLLSSGR---VQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQ 171 Query: 155 LVEGGLIF 162 L GG + Sbjct: 172 LKPGGRLI 179 >1TPY-A nrPDB Length = 287 Score = 34.8 bits (78), Expect = 0.052, Method: Composition-based stats. Identities = 28/136 (20%), Positives = 49/136 (36%), Gaps = 8/136 (5%) Query: 34 EEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI- 92 E+M + + A+ + L +LD+GCG G A +V+G+ +S Sbjct: 41 EDMTLEEAQIAKIDLALGKLG-LQPGMTLLDIGCGWGATMRRAIAQYDVNVVGLTLSKNQ 99 Query: 93 -IEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYAR 151 + K E++ D+ LL G VD I+S ++ D A Sbjct: 100 AAHVQKSFDEMDTPRDRRVLLAG----WEQFNEPVDRIVSIGAFEHFGHDRHADFFARAH 155 Query: 152 DHYLVEGGLIFPDKCS 167 L G++ + Sbjct: 156 -KILPPDGVLLLHTIT 170 >6AW7-A nrPDB Length = 228 Score = 34.8 bits (78), Expect = 0.054, Method: Composition-based stats. Identities = 27/159 (16%), Positives = 62/159 (38%), Gaps = 14/159 (8%) Query: 61 IVLDVGCGTGILSMFAAKH---GAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLE 117 +VL++G G ++ A+ GA+ + + ++++ G DK+T+L G + Sbjct: 61 LVLELGAYCGYSAVRMARLLSPGARLLTMEKNPDYAAITQQMLNFAGLQDKVTILIGASQ 120 Query: 118 DVHLPFPKVD------IIISEWMGYFLLYESMMDTV-LYARDHYLVEGGLIFPDKCS--I 168 D+ K D + + W +L +++ L + L+ +I P Sbjct: 121 DLIPQLKKYDVDTLDLVFLDHWKDRYLPDTILLEECGLLRKGTVLLADNVIVPGTPDFLA 180 Query: 169 HLAGLEDSQ--YKDEKLNYWQDVYGFDYSPFVPLVLHEP 205 ++ G + + L Y + V G + + + + Sbjct: 181 YVRGSSSFECTHYSSYLEYMKVVDGLEKAVYKGPSSPKQ 219 >1XTP-A nrPDB Length = 254 Score = 34.8 bits (78), Expect = 0.054, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 51/147 (34%), Gaps = 10/147 (6%) Query: 63 LDVGCGTGILSMFAAKHGAKHVIGV-DMSSIIEMAKELVELNGFSDKI-TLLRGKLEDVH 120 LD G G G ++ K+ + D+ ++ E + + + +E Sbjct: 98 LDCGAGIGRIT----KNLLTKLYATTDLLEPVKHMLEEAKRELAGMPVGKFILASMETAT 153 Query: 121 LPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSI---HLAGLEDSQ 177 LP D+I+ +W +L + + + G + F + CS L EDS Sbjct: 154 LPPNTYDLIVIQWTAIYLTDADFVKFFKHCQQALTPNGYIFFKENCSTGDRFLVDKEDSS 213 Query: 178 YKDEKLNYWQDVYGFDYSPFVPLVLHE 204 ++Y + ++ V E Sbjct: 214 LTRSDIHY-KRLFNESGVRVVKEAFQE 239 >5F8E-A nrPDB Length = 377 Score = 34.4 bits (77), Expect = 0.068, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 41/110 (37%), Gaps = 9/110 (8%) Query: 56 LFKDKIVLDVGCGTG-ILSMFAAKHGAKHVIGVDMSSIIEMA-KELVELNGFSDKITLLR 113 L V D GCG+G + + A GA G+D S A E G ++ T R Sbjct: 185 LRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANA-TFER 243 Query: 114 GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDT-VLYARDHYLVEGGLIF 162 L ++ D+I + +++ VL L GG++ Sbjct: 244 HDLAELD-KVGAYDVITV----FDAIHDQAQPARVLQNIYRALRPGGVLL 288 >1MJF-A nrPDB Length = 281 Score = 34.4 bits (77), Expect = 0.076, Method: Composition-based stats. Identities = 34/152 (22%), Positives = 53/152 (34%), Gaps = 19/152 (12%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM--------SSIIEMAKELVEL--NGFSD 107 K K VL +G G G +H VI V++ +I++ L+E NG + Sbjct: 75 KPKRVLVIGGGDGGTVREVLQHDVDEVIMVEIDEDVIMVSKDLIKIDNGLLEAMLNGKHE 134 Query: 108 KITLLRGKLEDVHLPFPKVDIIISE-----WMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 K L G + D+II++ L E V A L G+ Sbjct: 135 KAKLTIGDGFEFIKNNRGFDVIIADSTDPVGPAKVLFSEEFYRYVYDA----LNNPGIYV 190 Query: 163 PDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDY 194 S++L E E + VY + + Sbjct: 191 TQAGSVYLFTDELISAYKEMKKVFDRVYYYSF 222 >2B25-A nrPDB Length = 336 Score = 34.4 bits (77), Expect = 0.078, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 31/82 (37%), Gaps = 13/82 (15%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA--KHVIGVD--------MSSIIEMAK 97 N I+ D+ VL+ G G+G +S+F +K VI + + + Sbjct: 95 NMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWR 154 Query: 98 ELVEL---NGFSDKITLLRGKL 116 + +L + D + + + Sbjct: 155 DSWKLSHVEEWPDNVDFIHKDI 176 >1Y8C-A nrPDB Length = 246 Score = 34.4 bits (77), Expect = 0.080, Method: Composition-based stats. Identities = 34/154 (22%), Positives = 66/154 (42%), Gaps = 15/154 (9%) Query: 52 QNKDLFKDKIVLDVGCGTGILSM-FAAKHGAKHVIGVDMS-SIIEMAKELVELNGFSDKI 109 +N +F D LD+ CGTG L+ K K+ VD+S ++ A+ G ++ Sbjct: 33 ENNLVFDD--YLDLACGTGNLTENLCPKF--KNTWAVDLSQEMLSEAENKFRSQGLKPRL 88 Query: 110 TLLRGKLEDVHLPFPKVDIIISEWMGY-FLLYESMMDTVLYARDHYLVEGGLIFPDKCSI 168 + ++++ K D+I +++ + A ++L EGG+ D S Sbjct: 89 AC--QDISNLNI-NRKFDLITCCLDSTNYIIDSDDLKKYFKAVSNHLKEGGVFIFDINSY 145 Query: 169 H----LAGLEDSQYKDEKL-NYWQDVYGFDYSPF 197 + + G D Y D+++ YW++ + D Sbjct: 146 YKLSQVLGNNDFNYDDDEVFYYWENQFEDDLVSM 179 >1P91-A nrPDB Length = 269 Score = 34.4 bits (77), Expect = 0.081, Method: Composition-based stats. Identities = 27/110 (24%), Positives = 42/110 (38%), Gaps = 15/110 (13%) Query: 31 GIHEEMLQ------DTVRTLSYRNAII-QNKDLFKDKI--VLDVGCGTGILSMFAAKHGA 81 G EM+Q D R+AI+ Q ++ DK VLD+GCG G + A Sbjct: 49 GDSAEMMQARRAFLDAGHYQPLRDAIVAQLRERLDDKATAVLDIGCGEGYYTHAFADALP 108 Query: 82 K-HVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIII 130 + G+D+S + A ++T + +D II Sbjct: 109 EITTFGLDVSKVAIKA-----AAKRYPQVTFCVASSHRLPFSDTSMDAII 153 >5XJ2-A nrPDB Length = 454 Score = 34.4 bits (77), Expect = 0.082, Method: Composition-based stats. Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 3/63 (4%) Query: 46 YRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNG 104 Y+ AI +L KD +++D G G + + AKH K V GV++ +E +++ LN Sbjct: 293 YQTAIDF-AELKKDDVIIDAYSGIGTIGLSVAKHV-KEVYGVELIPEAVENSQKNASLNK 350 Query: 105 FSD 107 ++ Sbjct: 351 ITN 353 >1P1B-A nrPDB Length = 199 Score = 34.4 bits (77), Expect = 0.085, Method: Composition-based stats. Identities = 21/133 (15%), Positives = 44/133 (33%), Gaps = 5/133 (3%) Query: 41 VRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELV 100 R + + + VL+VG G I + + K ++ + + + Sbjct: 6 ERWETPYMHSLAAAAASRGGRVLEVGFGMAIAASRVQQAPIKEHWIIECNDGVFQRLQNW 65 Query: 101 ELNGFSDKITLLRGKLEDV--HLPFPKVDIIISE--WMGYFLLYESMMDTVLYARDHYLV 156 L K+ L+G E+V LP D I+ + + + + + L Sbjct: 66 ALKQP-HKVVPLKGLWEEVAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKTHAFRLLK 124 Query: 157 EGGLIFPDKCSIH 169 GG++ + Sbjct: 125 PGGILTYCNLTSW 137 >2FHP-A nrPDB Length = 187 Score = 34.4 bits (77), Expect = 0.086, Method: Composition-based stats. Identities = 17/103 (16%), Positives = 42/103 (40%), Gaps = 6/103 (5%) Query: 38 QDTVRTLSYRNAII-QNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEM 95 T + +I F + LD+ G+G L++ A G I ++ + + +++ Sbjct: 23 NTRPTTDKVKESIFNMIGPYFDGGMALDLYSGSGGLAIEAVSRGMDKSICIEKNFAALKV 82 Query: 96 AKELVELNGFSDKITLLRGK----LEDVHLPFPKVDIIISEWM 134 KE + + +K + + LE + + D+++ + Sbjct: 83 IKENIAITKEPEKFEVRKMDANRALEQFYEEKLQFDLVLLDPP 125 >2YXE-A nrPDB Length = 215 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 22/111 (19%), Positives = 42/111 (37%), Gaps = 13/111 (11%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAK-HGAKH-VIGVD-MSSIIEMAKELVELNGFSDKITL 111 DL VL++G G G + A+ G V+ ++ + + E A+ + G+ + I + Sbjct: 74 DLKPGMKVLEIGTGCGYHAAVTAEIVGEDGLVVSIERIPELAEKAERTLRKLGYDNVI-V 132 Query: 112 LRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + G + P D I + G + L +GG + Sbjct: 133 IVGDGTLGYEPLAPYDRIYTTAAG---------PKIPEPLIRQLKDGGKLL 174 >5Z7M-A nrPDB Length = 546 Score = 33.6 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 33/164 (20%), Positives = 49/164 (29%), Gaps = 13/164 (7%) Query: 172 GLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVK 231 Q + + W D Y ++ + L P + + T SD Sbjct: 208 PFAALQKAQKGVTAWDDPYKGNFGQLMALKQAHPDLKILPSIGGWTLSDPFFFM------ 261 Query: 232 ISDLAFKSNFKLTAKRQDMINGIVTWFDI--VFPAPKGKRPVEFSTGPHAPYTHWKQTIF 289 D + F + K DI FP KG P S Y + + Sbjct: 262 -GDKVKRDRFVGSVKEFLQTWKFFDGVDIAWEFPGGKGANPNLGSPQDGETYVLLMKELR 320 Query: 290 YFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGID 333 D L ETG E S + D+ K++Y N +D Sbjct: 321 AMLDQLSVETGRKYELTSAISAGK----DMIDKVAYNVAQNSMD 360 >3HEM-A nrPDB Length = 302 Score = 33.6 bits (75), Expect = 0.14, Method: Composition-based stats. Identities = 23/128 (17%), Positives = 44/128 (34%), Gaps = 3/128 (2%) Query: 47 RNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFS 106 R + +L +LD+GCG G A +VIG+ +S + A + + Sbjct: 61 RKLALDKLNLEPGMTLLDIGCGWGSTMRHAVAEYDVNVIGLTLSEN-QYAHDKAMFDEVD 119 Query: 107 DKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKC 166 +++ VD I+S + + D D + + + PD Sbjct: 120 SPRRKEV-RIQGWEEFDEPVDRIVS-LGAFEHFADGAGDAGFERYDTFFKKFYNLTPDDG 177 Query: 167 SIHLAGLE 174 + L + Sbjct: 178 RMLLHTIT 185 >4LEC-A nrPDB Length = 212 Score = 33.6 bits (75), Expect = 0.14, Method: Composition-based stats. Identities = 15/47 (31%), Positives = 25/47 (53%), Gaps = 1/47 (2%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELN 103 + + +++G GTG++ + AA GA HV D +E K V+ N Sbjct: 58 LRGRSAVELGAGTGLVGIVAALLGA-HVTITDRKVALEFLKSNVQAN 103 >2YVL-A nrPDB Length = 248 Score = 33.2 bits (74), Expect = 0.15, Method: Composition-based stats. Identities = 19/126 (15%), Positives = 45/126 (35%), Gaps = 10/126 (7%) Query: 56 LFKDKIVLDVGCGTG-ILSMFAAKHGAKHVI-GVDMSSIIEMAKELVELNGFSDKITLLR 113 L K+K VL+ G G+G +L++ + G V+ + A++ ++ + Sbjct: 89 LNKEKRVLEFGTGSGALLAVLSEVAGEVWTFEAVE--EFYKTAQKNLKKFNLGKNVKFFN 146 Query: 114 GKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGL 173 +D +P + + E + +++ G + P + + L Sbjct: 147 VDFKDAEVPEGIFHAAFVDVREPWHYLEKVHKSLMEGA-----PVGFLLP-TANQVIKLL 200 Query: 174 EDSQYK 179 E + Sbjct: 201 ESIENY 206 >3M70-A nrPDB Length = 286 Score = 33.2 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 28/150 (18%), Positives = 49/150 (32%), Gaps = 5/150 (3%) Query: 25 NSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHV 84 + Y E+ T + ++ + VLD+GCG G S++ + G V Sbjct: 87 CTLGFYCKKEDYFSKKYNTTAIHGDVVDAAKIISPCKVLDLGCGQGRNSLYLSLLGYD-V 145 Query: 85 IGVDMSSI-IEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESM 143 D + I E E + L ++ D I+S + FL E + Sbjct: 146 TSWDHNENSIAFLNETKEKENLNISTALYDINAANIQ---ENYDFIVSTVVFMFLNRERV 202 Query: 144 MDTVLYARDHYLVEGGLIFPDKCSIHLAGL 173 + ++H V G + S Sbjct: 203 PSIIKNMKEHTNVGGYNLIVAAMSTDDVPC 232 >6F5Z-A nrPDB Length = 231 Score = 33.2 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 30/158 (18%), Positives = 58/158 (36%), Gaps = 24/158 (15%) Query: 56 LFKDKIVLDVGCGTGILSMFAAK--HGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLR 113 + + V+D+G G+G ++ A + G G+D S + +D ++ L Sbjct: 36 VEEGDTVVDLGTGSG-YALRALRDTKGIGRGFGLDGSP---EMVQNARAYTDTDDLSFLV 91 Query: 114 GKLEDVHLPFPKVDIIIS-EWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAG 172 G +D+ VD + S E Y ++ + L GG + C++ Sbjct: 92 GDFDDLPFDDDSVDHVWSMEAFYYAADPHHTLEEI----ARILKPGGTFY---CAV---- 140 Query: 173 LEDSQYKDEKLNY--WQDVYGFDYSPFVPLVLHEPIVD 208 Y +E ++ WQ+ D + + E D Sbjct: 141 ----NYYEENVHSHEWQEHISIDMTRWSHAEYREAFRD 174 >3HP7-A nrPDB Length = 291 Score = 33.2 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 15/119 (12%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLE 117 +D I +D+G TG + ++GAK V VD+ +LV D++ +E Sbjct: 85 EDMITIDIGASTGGFTDVMLQNGAKLVYAVDVG-----TNQLVWKLRQDDRV----RSME 135 Query: 118 DVHLP-FPKVDIIISEWMGYFLLYES---MMDTVLYARDHYLVEGGLIFPDKCSIHLAG 172 + VD +E + F + ++ +L A LV+GG + AG Sbjct: 136 QYNFRYAEPVD--FTEGLPSFASIDVSFISLNLILPALAKILVDGGQVVALVKPQFEAG 192 >4MTL-A nrPDB Length = 244 Score = 32.8 bits (73), Expect = 0.20, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 23/37 (62%), Gaps = 1/37 (2%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSII 93 F+D +L++G G G++S+ A+ GA V D+ ++ Sbjct: 91 FQDAKILEIGAGPGLVSIVASILGA-QVTATDLPDVL 126 >4G1P-A nrPDB Length = 487 Score = 32.8 bits (73), Expect = 0.20, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 41/110 (37%), Gaps = 3/110 (2%) Query: 27 YDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIG 86 Y HY + L+D T ++ I + K + K + V D TG L + A G Sbjct: 100 YGHYDVQPAQLEDGWDTEPFKLVIDEAKGIMKGRGVTD---DTGPLLSWINVVDAFKASG 156 Query: 87 VDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGY 136 + + E +E +G L++ + V I + W+G Sbjct: 157 QEFPVNLVTCFEGMEESGSLKLDELIKKEANGYFKGVDAVCISDNYWLGT 206 >3C3P-A nrPDB Length = 210 Score = 32.8 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 37/85 (43%), Gaps = 3/85 (3%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA--KHVIGVDMS-SIIEMAKELVELNG 104 + + + ++V+ G G G S + A+ + V+ +D +E A+ ++ NG Sbjct: 46 RLLYLLARIKQPQLVVVPGDGLGCASWWFARAISISSRVVMIDPDRDNVEHARRMLHDNG 105 Query: 105 FSDKITLLRGKLEDVHLPFPKVDII 129 D++ L G + +DI+ Sbjct: 106 LIDRVELQVGDPLGIAAGQRDIDIL 130 >5EHG-A nrPDB Length = 276 Score = 32.8 bits (73), Expect = 0.23, Method: Composition-based stats. Identities = 32/136 (23%), Positives = 59/136 (43%), Gaps = 19/136 (13%) Query: 13 KTKLSESEQHYFNSYDHYGIHE----EMLQDTVRTLSYRNAIIQNKD----------LFK 58 K KL++ + F+ Y GI E E + R + +A+ + + Sbjct: 14 KKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAVSRGSAKLQWFVERNMVIP 73 Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFS-DKITLLRGKL 116 + V+D+GCG G S + A G K V V + +E V ++ + + + L+ GK Sbjct: 74 EGRVIDLGCGRGGWSYYCA--GLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGK- 130 Query: 117 EDVHLPFPKVDIIISE 132 + +LP K D ++ + Sbjct: 131 DVFYLPPEKCDTLLCD 146 >3OPN-A nrPDB Length = 232 Score = 32.8 bits (73), Expect = 0.23, Method: Composition-based stats. Identities = 13/46 (28%), Positives = 21/46 (45%) Query: 44 LSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM 89 L A+ + K LD+G TG + ++GAK V +D+ Sbjct: 23 LKLEKALKEFHLEINGKTCLDIGSSTGGFTDVMLQNGAKLVYALDV 68 >4DZR-A nrPDB Length = 215 Score = 32.8 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 27/59 (45%), Gaps = 2/59 (3%) Query: 48 NAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAK-HVIGVDMS-SIIEMAKELVELNG 104 AI K + V+DVG G+G +++ A V VD+S + +A+ E G Sbjct: 20 EAIRFLKRMPSGTRVIDVGTGSGCIAVSIALACPGVSVTAVDLSMDALAVARRNAERFG 78 >3G5T-A nrPDB Length = 299 Score = 32.4 bits (72), Expect = 0.27, Method: Composition-based stats. Identities = 33/208 (15%), Positives = 71/208 (34%), Gaps = 21/208 (10%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGA--KHVIGVDMSSIIEMAKELVELNGFSD--KIT 110 + K+++DVGCG G ++ A+ + +IG D+S+ + E+++ ++ Sbjct: 33 HDGERKLLVDVGCGPGTATLQMAQELKPFEQIIGSDLSATMIKTAEVIKEGSPDTYKNVS 92 Query: 111 LLRGKLEDVHL------PFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGL---- 160 +D K+D+I + ++ +E + A + +G + Sbjct: 93 FKISSSDDFKFLGADSVDKQKIDMITAVECAHWFDFEKFQRS---AYANLRKDGTIAIWG 149 Query: 161 ----IFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVN 216 IFPD +E K YW+ + +P + + + Sbjct: 150 YADPIFPDYPEFDDLMIEVPYGKQGLGPYWEQPGRSRLRNMLKDSHLDPELFHDIQVSYF 209 Query: 217 TTSDKLIEFDLNTVKISDLAFKSNFKLT 244 D + L+ L + L Sbjct: 210 CAEDVRDKVKLHQHTKKPLLIRKQVTLV 237 >4UEJ-A nrPDB Length = 346 Score = 32.4 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 15/36 (41%), Positives = 24/36 (66%), Gaps = 2/36 (5%) Query: 58 KDKIVLDVGCGT-GILSMFAAKH-GAKHVIGVDMSS 91 ++K V+ +G GT G+L++ A GAK V +D+SS Sbjct: 160 ENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISS 195 >3E23-A nrPDB Length = 211 Score = 32.4 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 38/125 (30%), Gaps = 13/125 (10%) Query: 40 TVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKEL 99 R +L +L++GCG G + A V D S E+A E Sbjct: 25 AERQPRSATLTKFLGELPAGAKILELGCGAGYQA-EAMLAAGFDVDATDGSP--ELAAEA 81 Query: 100 VELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLY--ESMMDTVLYARDHYLVE 157 G + L +D + W LL+ + VL L Sbjct: 82 SRRLGRPVRTMLFH--------QLDAIDAYDAVWAHACLLHVPRDELADVLKLIWRALKP 133 Query: 158 GGLIF 162 GGL + Sbjct: 134 GGLFY 138 >1R18-A nrPDB Length = 227 Score = 32.4 bits (72), Expect = 0.32, Method: Composition-based stats. Identities = 16/53 (30%), Positives = 23/53 (43%), Gaps = 5/53 (9%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSI---IEMAKELVELNG 104 L +LDVG G+G L+ ++ GVD + IE ELV + Sbjct: 81 HLKPGARILDVGSGSGYLTACFYRYIKAK--GVDADTRIVGIEHQAELVRRSK 131 >2PWY-A nrPDB Length = 258 Score = 32.1 bits (71), Expect = 0.36, Method: Composition-based stats. Identities = 20/83 (24%), Positives = 34/83 (40%), Gaps = 3/83 (3%) Query: 55 DLFKDKIVLDVGCGTGILSMFAAKHGAKH--VIGVDMSS-IIEMAKELVELNGFSDKITL 111 DL VL+ G G+G L++F A+ + V + + A+ V + + Sbjct: 93 DLAPGMRVLEAGTGSGGLTLFLARAVGEKGLVESYEARPHHLAQAERNVRAFWQVENVRF 152 Query: 112 LRGKLEDVHLPFPKVDIIISEWM 134 GKLE+ L D + + M Sbjct: 153 HLGKLEEAELEEAAYDGVALDLM 175 >2PLW-A nrPDB Length = 201 Score = 32.1 bits (71), Expect = 0.37, Method: Composition-based stats. Identities = 27/116 (23%), Positives = 50/116 (43%), Gaps = 21/116 (18%) Query: 45 SYRNAIIQNKDLF--KDKIVLDVGCGTGILS---MFAAKHGAKHVIGVDMS--------- 90 +Y+ + NK LF K+KI+LD+GC G + K+ +IG+D Sbjct: 7 AYKLIELDNKYLFLKKNKIILDIGCYPGSWCQVILERTKNYKNKIIGIDKKIMDPIPNVY 66 Query: 91 ----SIIEMAKELVELNGFSDKI--TLLRGKLEDVHLPFPKVDIIISEWMGYFLLY 140 I + ++ + D + + KL+++ L K+DII+S+ + Sbjct: 67 FIQGEIGKDNMNNIKNINYIDNMNNNSVDYKLKEI-LQDKKIDIILSDAAVPCIGN 121 >3TFW-A nrPDB Length = 248 Score = 32.1 bits (71), Expect = 0.37, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 48/114 (42%), Gaps = 14/114 (12%) Query: 56 LFKDKIVLDVGCGTGILSMFAAKH--GAKHVIGVDMSSI-IEMAKELVELNGFSDKITLL 112 L + K +L++G G +++ A+ ++ ++ + ++A+E ++L G ++TL Sbjct: 61 LTQAKRILEIGTLGGYSTIWMARELPADGQLLTLEADAHHAQVARENLQLAGVDQRVTLR 120 Query: 113 RGK-LEDVHL--PFPKVDIIISEWMGYFLLYES-MMDTVLYARDHYLVEGGLIF 162 G L+ + P D+I F+ + L Y G LI Sbjct: 121 EGPALQSLESLGECPAFDLI-------FIDADKPNNPHYLRWALRYSRPGTLII 167 >4HG2-A nrPDB Length = 257 Score = 32.1 bits (71), Expect = 0.40, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 28/70 (40%), Gaps = 7/70 (10%) Query: 63 LDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLP 122 LD GCG+G S+ A+ + V VD + ++T ED LP Sbjct: 44 LDCGCGSGQASLGLAEFFER-VHAVDPGE------AQIRQALRHPRVTYAVAPAEDTGLP 96 Query: 123 FPKVDIIISE 132 VD+ I+ Sbjct: 97 PASVDVAIAA 106 >3NDI-A nrPDB Length = 416 Score = 32.1 bits (71), Expect = 0.41, Method: Composition-based stats. Identities = 26/153 (16%), Positives = 59/153 (38%), Gaps = 16/153 (10%) Query: 14 TKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILS 73 T+ + + Y ++ ++++ L+ + + D ++++GC GI+ Sbjct: 65 TEEVPRDLMFHEVYPYHSSGSSVMREHFAMLA--RDFLATELTGPDPFIVEIGCNDGIML 122 Query: 74 MFAAKHGAKHVIGVDMSS-IIEMAKE---LVELNGFSDKITLLRGKLEDVHLPFPKVDII 129 + G +H +G + SS + A+E V + F + +DV ++I Sbjct: 123 RTIQEAGVRH-LGFEPSSGVAAKAREKGIRVRTDFFE------KATADDVRRTEGPANVI 175 Query: 130 ISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + L + + +VL D L G+ Sbjct: 176 YA---ANTLCHIPYVQSVLEGVDALLAPDGVFV 205 >4V0R-A nrPDB Length = 892 Score = 32.1 bits (71), Expect = 0.42, Method: Composition-based stats. Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 5/85 (5%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFS-D 107 ++ + + V+D+GCG G S + A G K V V + +E V ++ + + Sbjct: 62 FVERNMVIPEGRVIDLGCGRGGWSYYCA--GLKKVTEVRGYTKGGPGHEEPVPMSTYGWN 119 Query: 108 KITLLRGKLEDVHLPFPKVDIIISE 132 + L+ GK + +LP K D ++ + Sbjct: 120 IVKLMSGK-DVFYLPPEKCDTLLCD 143 >5IKM-A nrPDB Length = 269 Score = 31.7 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 16/45 (35%), Positives = 22/45 (48%), Gaps = 3/45 (6%) Query: 43 TLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGV 87 T R + +N + K V+D+GCG G S + A G K V V Sbjct: 62 TAKLRWFVERNLVKPEGK-VIDLGCGRGGWSYYCA--GLKKVTEV 103 >3TR6-A nrPDB Length = 225 Score = 31.7 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 42/169 (24%), Positives = 64/169 (37%), Gaps = 29/169 (17%) Query: 5 AVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLD 64 ++ S E L+E + S+ Y +Q +++ L + K V+D Sbjct: 19 LLQVSLREPPLLAELREETTRSFSTYA-----MQTAPEQAQLLALLVK---LMQAKKVID 70 Query: 65 VGCGTGI----LSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLED-- 118 +G TG + + K G VD S +AKE E G SDKI L +D Sbjct: 71 IGTFTGYSAIAMGLALPKDGTLITCDVDEKSTA-LAKEYWEKAGLSDKIGLRLSPAKDTL 129 Query: 119 ---VHLPFP-KVDIII--SEWMGYFLLYESMMDTVLYARDHYLVEGGLI 161 +H + D+I ++ L YE + L EGGLI Sbjct: 130 AELIHAGQAWQYDLIYIDADKANTDLYYEESL--------KLLREGGLI 170 >5ZL9-A nrPDB Length = 618 Score = 31.3 bits (69), Expect = 0.62, Method: Composition-based stats. Identities = 33/173 (19%), Positives = 47/173 (27%), Gaps = 22/173 (12%) Query: 172 GLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVK 231 Q + + W D Y ++ + L P + + T SD Sbjct: 208 PFAALQKAQKGVTAWDDPYKGNFGQLMALKQAHPDLKILPSIGGWTLSDPFFFM------ 261 Query: 232 ISDLAFKSNFKLTAKRQDMINGIVTWFDI--VFPAPKGKRPVEFSTGPHAPYTHWKQTIF 289 D + F + K DI FP KG P S Y + + Sbjct: 262 -GDKVKRDRFVGSVKEFLQTWKFFDGVDIDWEFPGGKGANPNLGSPQDGETYVLLMKELR 320 Query: 290 YFPDDLDAETGDTIEGELVCSPNEK-------------NNRDLNIKISYKFES 329 D L ETG E S + N+ D +SY F Sbjct: 321 AMLDQLSVETGRKYELTSAISAGKDKIDKFYSFVNVAQNSMDHIFLMSYDFYG 373 >4DCM-A nrPDB Length = 375 Score = 31.3 bits (69), Expect = 0.63, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 27/62 (43%), Gaps = 3/62 (4%) Query: 47 RNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA-KHVIGVDMSSIIEM-AKELVELNG 104 R + + + +IV D+GCG G++ + V+ VD S + ++ VE N Sbjct: 212 RFFMQHLPENLEGEIV-DLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNM 270 Query: 105 FS 106 Sbjct: 271 PE 272 >6GFK-A nrPDB Length = 251 Score = 31.3 bits (69), Expect = 0.64, Method: Composition-based stats. Identities = 16/67 (23%), Positives = 28/67 (41%), Gaps = 6/67 (8%) Query: 53 NKDLFKDKIVL----DVGCG-TGILSMFAAKHGAKHVIGVDMSSII-EMAKELVELNGFS 106 DK L D+G G + I + A + + ++ + AK+ VE N S Sbjct: 53 IGHQDSDKSTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQNNLS 112 Query: 107 DKITLLR 113 D I +++ Sbjct: 113 DLIKVVK 119 >6DU5-A nrPDB Length = 313 Score = 31.3 bits (69), Expect = 0.64, Method: Composition-based stats. Identities = 16/67 (23%), Positives = 28/67 (41%), Gaps = 6/67 (8%) Query: 53 NKDLFKDKIVL----DVGCG-TGILSMFAAKHGAKHVIGVDMSSII-EMAKELVELNGFS 106 DK L D+G G + I + A + + ++ + AK+ VE N S Sbjct: 96 IGHQDSDKSTLRRGIDIGTGASCIYPLLGATLNGWYFLATEVDDMCFNYAKKNVEQNNLS 155 Query: 107 DKITLLR 113 D I +++ Sbjct: 156 DLIKVVK 162 >6G4W-q nrPDB Length = 281 Score = 30.9 bits (68), Expect = 0.76, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 2/39 (5%) Query: 62 VLDVGCGTGILSMFAAKHGAKHVIGVDMSS-IIEMAKEL 99 +LD+GCGTG+ + + G V G+D+S +++ A + Sbjct: 57 LLDIGCGTGLSGSYLSDEGHYWV-GLDISPAMLDEAVDR 94 >1RQX-A nrPDB Length = 338 Score = 30.9 bits (68), Expect = 0.77, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 34/83 (40%), Gaps = 13/83 (15%) Query: 70 GILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFP--KVD 127 G++ FAA A VIGVD S+ +E + + R E V L + D Sbjct: 205 GMVVGFAADGRADRVIGVDASAKPAQTREQITR--------IARQTAEKVGLERDIMRAD 256 Query: 128 IIISEWMG---YFLLYESMMDTV 147 +++ E Y L E ++ + Sbjct: 257 VVLDERFAGPEYGLPNEGTLEAI 279 >3O4F-A nrPDB Length = 294 Score = 30.9 bits (68), Expect = 0.77, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 52/164 (31%), Gaps = 11/164 (6%) Query: 46 YRNAIIQNKDLFKD--KIVLDVGCGTGILSMFAAKH-GAKHVIGVDMS----SIIEMAKE 98 Y + L K VL +G G G + +H + + V++ S Sbjct: 69 YHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLP 128 Query: 99 LVELNGFSDK--ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYAR-DHYL 155 + D ++ + V+ D+IIS+ ES+ + Y L Sbjct: 129 NHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCL 188 Query: 156 VEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVP 199 GG+ L E + +Y+ DV GF + Sbjct: 189 NPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDV-GFYQAAIPT 231 >3NJR-A nrPDB Length = 204 Score = 30.9 bits (68), Expect = 0.77, Method: Composition-based stats. Identities = 18/111 (16%), Positives = 45/111 (40%), Gaps = 8/111 (7%) Query: 58 KDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLE 117 + +++ D+G G+G +S+ G + + + IE ++ ++ G S ++ ++G Sbjct: 55 RGELLWDIGGGSGSVSVEWCLAGGRAITIEPRADRIENIQKNIDTYGLSPRMRAVQGTA- 113 Query: 118 DVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSI 168 P D+ + E F+ + +L G I + ++ Sbjct: 114 ----PAALADLPLPE--AVFIGG-GGSQALYDRLWEWLAPGTRIVANAVTL 157 >3LST-A nrPDB Length = 348 Score = 30.9 bits (68), Expect = 0.78, Method: Composition-based stats. Identities = 18/120 (15%), Positives = 39/120 (32%), Gaps = 8/120 (6%) Query: 1 MSKTAVKDSATEKTKLS----ESEQHYFNSYDHY-GIHEEMLQDTVRTLSYRNAIIQNKD 55 MS E+ + S YF+ ++ E ++ + + D Sbjct: 124 MSHRVASALGPERPAFADIFGSSLDAYFDGDAEVEALYYEGMETVSAAE--HLILARAGD 181 Query: 56 LFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGK 115 V DVG G G + + + GV + +A+ ++ + + ++ G Sbjct: 182 FPATGTVADVGGGRGGFLLTVLREHPG-LQGVLLDRAEVVARHRLDAPDVAGRWKVVEGD 240 >3R9X-B nrPDB Length = 248 Score = 30.9 bits (68), Expect = 0.79, Method: Composition-based stats. Identities = 11/66 (16%), Positives = 28/66 (42%), Gaps = 4/66 (6%) Query: 56 LFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGK 115 + + V++VG GTG L+ +H K + +++ E ++ G +++ ++ Sbjct: 28 IEEGNTVVEVGGGTGNLTKVLLQHPLKKLYVIELDR---EMVENLKSIG-DERLEVINED 83 Query: 116 LEDVHL 121 Sbjct: 84 ASKFPF 89 >2ZIG-A nrPDB Length = 297 Score = 30.9 bits (68), Expect = 0.96, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 28/59 (47%), Gaps = 2/59 (3%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM-SSIIEMAKELVELNGFSDKITLLRG 114 F +VLD GTG + AA+ G + +GV++ ++AKE + +L G Sbjct: 234 FVGDVVLDPFAGTGTTLIAAARWG-RRALGVELVPRYAQLAKERFAREVPGFSLEVLDG 291 >2ZFU-A nrPDB Length = 215 Score = 30.5 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 28/86 (32%), Gaps = 10/86 (11%) Query: 102 LNGFSDKITLLRGKLEDVHLPFPKVDIII--SEWMGYFLLYESMMDTVLYARDHYLVEGG 159 L ++T+ + V L VD+ + MG + L + L GG Sbjct: 94 LASLDPRVTVC--DMAQVPLEDESVDVAVFCLSLMGTNI------RDFLEEANRVLKPGG 145 Query: 160 LIFPDKCSIHLAGLEDSQYKDEKLNY 185 L+ + S + KL + Sbjct: 146 LLKVAEVSSRFEDVRTFLRAVTKLGF 171 >3BXO-A nrPDB Length = 239 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 14/109 (12%) Query: 58 KDKIVLDVGCGTGI-LSMFAAKHGAKHVIGVDMS-SIIEMAKELVELNGFSDKITLLRGK 115 + +LDV CGTG L F + G G+++S ++ A++ + TL +G Sbjct: 40 EASSLLDVACGTGTHLEHFTKEFGDTA--GLELSEDMLTHARKRLPDA------TLHQGD 91 Query: 116 LEDVHLPFPKVDIIISEW--MGYFLLYESMMDTVLYARDHYLVEGGLIF 162 + D L K ++S + +GY E + V +H L GG++ Sbjct: 92 MRDFRLGR-KFSAVVSMFSSVGYLKTTEELGAAVASFAEH-LEPGGVVV 138 >3EVC-A nrPDB Length = 277 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 18/38 (47%), Gaps = 2/38 (5%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGV 87 + + + V+D+GCG G +AA K V GV Sbjct: 66 FHERGYVKLEGRVIDLGCGRGGWCYYAA--AQKEVSGV 101 >3G7U-A nrPDB Length = 376 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 27/57 (47%), Gaps = 2/57 (3%) Query: 62 VLDVGCGTGILSMFAAKHG--AKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKL 116 V+D+ G G LS+ AA+ G K + +D +I A + ++LL ++ Sbjct: 5 VIDLFSGVGGLSLGAARAGFDVKMAVEIDQHAINTHAINFPRSLHVQEDVSLLNAEI 61 >4DMG-A nrPDB Length = 393 Score = 30.1 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 18/34 (52%), Gaps = 1/34 (2%) Query: 56 LFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDM 89 + + VLDV G ++ AA+ GA + + VD Sbjct: 212 VRPGERVLDVYSYVGGFALRAARKGA-YALAVDK 244 >2VDV-E nrPDB Length = 246 Score = 30.1 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 11/29 (37%), Positives = 16/29 (55%), Gaps = 2/29 (6%) Query: 44 LSYRNAIIQNKDLFKDKIVLDVGCGTGIL 72 Y+NA +N + K + D+GCG G L Sbjct: 37 PYYKNA--ENGQMTKKVTIADIGCGFGGL 63 >3UFB-A nrPDB Length = 530 Score = 30.1 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 37/94 (39%), Gaps = 18/94 (19%) Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKE-----------LVELNGFSD 107 + VLD CGTG + A +H + V+ +++ + LV++N Sbjct: 218 GESVLDPACGTGGFLVEAFEHLERQCKTVEDREVLQESSIFGGEAKSLPYLLVQMNLLLH 277 Query: 108 KITLLRGKLED-VHLP------FPKVDIIISEWM 134 + R E+ + P +VD+I++ Sbjct: 278 GLEYPRIDPENSLRFPLREMGDKDRVDVILTNPP 311 >5JWY-A nrPDB Length = 259 Score = 30.1 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 14/36 (38%), Gaps = 2/36 (5%) Query: 138 LLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGL 173 L E + L R H+ E G FP ++ A Sbjct: 137 LAEEKNIPQYL--RSHWQKETGFAFPSGHTMFAASW 170 >5UBB-A nrPDB Length = 222 Score = 30.1 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 28/106 (26%), Positives = 47/106 (44%), Gaps = 13/106 (12%) Query: 63 LDVGCGTGILSMFAAKHGAKHVI-GVDMSSIIEMAKELVELNGF----SDKIT-LLRGKL 116 LD G G G +S KH V V++ ++E L+E + DK+ L Sbjct: 65 LDCGSGIGRVS----KHVLLPVFNSVELVDMMESF--LLEAQNYLQVKGDKVESYHCYSL 118 Query: 117 EDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIF 162 ++ PF + D+I +W+ L + ++ + RD L E G+I Sbjct: 119 QEFTPPFRRYDVIWIQWVSGHLTDKDLLAFLSRCRDG-LKENGIII 163 >3GCZ-A nrPDB Length = 282 Score = 30.1 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 46/136 (33%), Gaps = 22/136 (16%) Query: 50 IIQNKDLFKDKIVLDVGCGTGILSMFAA-----KHGAKHVIGVDM--SSIIEMAKE--LV 100 + + + IV+D+GCG G S +AA K +GV I+ L+ Sbjct: 82 MEERGYVKPTGIVVDLGCGRGGWSYYAASLKNVKKVMAFTLGVQGHEKPIMRTTLGWNLI 141 Query: 101 ELNGFSDK--ITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEG 158 +D + ++ G + I + E + + VL +L EG Sbjct: 142 RFKDKTDVFNMEVIPGDTLLCDIGESSPSIAVEE--------QRTLR-VLNCAKQWLQEG 192 Query: 159 GLIFPDKCSIHLAGLE 174 + + C L Sbjct: 193 N--YTEFCIKVLCPYT 206 >2ZLB-A nrPDB Length = 223 Score = 29.7 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 50/110 (45%), Gaps = 7/110 (6%) Query: 61 IVLDVGCGTGILSMFAAKH---GAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLE 117 +VL++G G ++ A+ GA+ + + ++++ G DK+T+L G + Sbjct: 63 LVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQ 122 Query: 118 DVHLPFPKVDIIISEWMGYFLLY---ESMMDTVLYARDHYLVEGGLIFPD 164 D+ +P K + FL + + DT+L + L +G ++ D Sbjct: 123 DL-IPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLAD 171 >3JWJ-A nrPDB Length = 202 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 42/86 (48%), Gaps = 12/86 (13%) Query: 39 DTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTG-ILSMFAAKHGAKHVIGVDMS-SIIEMA 96 + R A+ Q+ + V+D+GCG G +L + + + GVD+S +E+A Sbjct: 4 NQQRMNGVVAALKQSNA----RRVIDLGCGQGNLLKILLKDSFFEQITGVDVSYRSLEIA 59 Query: 97 KELVE-----LNGFSDKITLLRGKLE 117 +E ++ N + ++ L++G L Sbjct: 60 QERLDRLRLPRNQWE-RLQLIQGALT 84 >4TS7-A nrPDB Length = 210 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 29/85 (34%), Gaps = 3/85 (3%) Query: 146 TVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEP 205 V A Y+ I PD + + Y NYW+D + + Sbjct: 119 EVKTATLQYIKPAAKIIPDYYAEEIVSWAWFMYP---WNYWEDEINLVNKILIERKTKDI 175 Query: 206 IVDTVERNNVNTTSDKLIEFDLNTV 230 ++ ++RN V + + L+ + Sbjct: 176 DINELKRNFVESYGIENPPISLDKI 200 >5CVU-A nrPDB Length = 368 Score = 29.7 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 28/130 (21%), Positives = 49/130 (37%), Gaps = 19/130 (14%) Query: 43 TLSYRNAIIQNKDLFKDKIVLDVGCGTG-ILSMFAAKHGAKHVIGVDMSSIIEMAKELVE 101 T++ + + ++DVG GTG + SM AK+ + + I D+ +I+ A Sbjct: 188 TITMKKILEMYNGFEGLTTIVDVGGGTGAVASMIVAKYPSINAINFDLPHVIQDAPAF-- 245 Query: 102 LNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLI 161 + L G + D PK D I +W+ + E + L Sbjct: 246 -----SGVEHLGGDMFD---GVPKGDAIFIKWICHDWSDEHCL--------KLLKNCYAA 289 Query: 162 FPDKCSIHLA 171 PD + +A Sbjct: 290 LPDHGKVIVA 299 >2B3T-A nrPDB Length = 276 Score = 29.7 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 39/104 (37%), Gaps = 24/104 (23%) Query: 61 IVLDVGCGTGILSMFAAKHGAK-HVIGVD-MSSIIEMAKELVELNGFSDKITLLRGKLED 118 +LD+G GTG +++ A +I VD M + +A+ + Sbjct: 112 RILDLGTGTGAIALALASERPDCEIIAVDRMPDAVSLAQRNAQ----------------- 154 Query: 119 VHLPFPKVDIIISEWMGYFLLYESMM----DTVLYARDHYLVEG 158 HL + I+ S+W + M + +D +L +G Sbjct: 155 -HLAIKNIHILQSDWFSALAGQQFAMIVSNPPYIDEQDPHLQQG 197 >1ECF-A nrPDB Length = 504 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 36/97 (37%), Gaps = 6/97 (6%) Query: 29 HYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDV------GCGTGILSMFAAKHGAK 82 + G M +R S R + N+ F+DK VL V G + + A + GAK Sbjct: 329 YVGRTFIMPGQQLRRKSVRRKLNANRAEFRDKNVLLVDDSIVRGTTSEQIIEMAREAGAK 388 Query: 83 HVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDV 119 V + I + ++ +++++ Sbjct: 389 KVYLASAAPEIRFPNVYGIDMPSATELIAHGREVDEI 425 >5N5D-A nrPDB Length = 226 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 23/169 (13%), Positives = 55/169 (32%), Gaps = 16/169 (9%) Query: 33 HEEM-LQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGA--KHVIGVD- 88 H E L D + + L + + +L++G G S++ A+ ++ ++ Sbjct: 35 HREFDLPDLAVSAPQGKLLHLLARLRQARRILEIGTFGGYSSIWLARALPPDGRLVTIEW 94 Query: 89 MSSIIEMAKELVELNGFSDKITLLRGK----LEDVHLPFP-KVDIIISEWMGYFLLYESM 143 S E A + G + + G+ L + P D++ + + Sbjct: 95 ERSFAESAASRLAEAGVAHLVEQHVGRALDILPTLDRPGTAPFDMVFVD------ANKPD 148 Query: 144 MDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGF 192 + G ++ D + A + D + D + + + Sbjct: 149 IPEYFTWALKLSRPGAVVVVDNVVLGGA-VTDPDHPDAGVQGVRRFHEM 196 >2RBB-A nrPDB Length = 141 Score = 29.4 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 8/33 (24%), Positives = 13/33 (39%) Query: 273 FSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEG 305 P+ Y HW Q + P+ + +EG Sbjct: 103 LIKAPYETYYHWYQAVLLDPERNVFRINNVLEG 135 >5GQB-A nrPDB Length = 553 Score = 29.4 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 44/137 (32%), Gaps = 9/137 (6%) Query: 172 GLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVK 231 Q + L+ W + Y ++ + L +P + + T +D F Sbjct: 224 PWAALQKPQKGLSSWNEPYKGNFGQLMMLKQAKPDLKILPSIGGWTLADPFFFF------ 277 Query: 232 ISDLAFKSNFKLTAKRQDMINGIVTWFDI--VFPAPKGKRPVEFSTGPHAPYTHWKQTIF 289 +D + F + K DI FP KG P S Y + + Sbjct: 278 -TDETKRRRFVASVKDFLQTWKFFDGVDIDWEFPGGKGANPNLGSPKDGEIYVLLMKELR 336 Query: 290 YFPDDLDAETGDTIEGE 306 ++L AETG E Sbjct: 337 EMLNELSAETGRKYELT 353 >2PXA-A nrPDB Length = 269 Score = 29.4 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 17/38 (44%), Gaps = 6/38 (15%) Query: 40 TVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAA 77 +R L R + V+D+GCG G S +AA Sbjct: 61 KLRWLVERRFVQPIG------KVVDLGCGRGGWSYYAA 92 >4PEM-A nrPDB Length = 286 Score = 29.0 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 17/37 (45%), Gaps = 1/37 (2%) Query: 248 QDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHW 284 Q +G+ W D V +P P +FST P HW Sbjct: 120 QGYADGMNAWIDKVNASPDKLLPQQFSTFGFKPK-HW 155 >4PEL-A nrPDB Length = 222 Score = 29.0 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 17/37 (45%), Gaps = 1/37 (2%) Query: 248 QDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHW 284 Q +G+ W D V +P P +FST P HW Sbjct: 120 QGYADGMNAWIDKVNASPDKLLPQQFSTFGFKPK-HW 155 >5EOV-A nrPDB Length = 220 Score = 29.0 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 14/31 (45%) Query: 59 DKIVLDVGCGTGILSMFAAKHGAKHVIGVDM 89 + LD G TG + GA HV+ D+ Sbjct: 35 GRRCLDAGASTGGFTEVLLDRGAAHVVAADV 65 >5X7F-A nrPDB Length = 235 Score = 28.6 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 21/135 (15%), Positives = 48/135 (35%), Gaps = 18/135 (13%) Query: 43 TLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAA----KHGAKHVIGVDMSSIIEMAKE 98 T + + L K V +VG G G+ ++ G I ++ + +A++ Sbjct: 63 TPAVGALLCLLAKLSGGKAVAEVGTGAGVSGLWLLSGMRDDGVLTTIDIE-PEHLRLARQ 121 Query: 99 LVELNGFS-DKITLLRGKLEDV--HLPFPKVDIII--SEWMGYFLLYESMMDTVLYARDH 153 G + L+ G+ ++V L D++ ++ + + Sbjct: 122 AFAEAGIGPSRTRLISGRAQEVLTRLADASYDLVFIDADPIDQ--------PDYVAEGVR 173 Query: 154 YLVEGGLIFPDKCSI 168 L GG+I + ++ Sbjct: 174 LLRSGGVIVVHRAAL 188 >5DF0-A nrPDB Length = 545 Score = 28.2 bits (61), Expect = 4.9, Method: Composition-based stats. Identities = 17/101 (16%), Positives = 32/101 (31%), Gaps = 9/101 (8%) Query: 172 GLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVK 231 Q + ++ W + Y ++ + L P + + T SD Sbjct: 221 PWAAVQKPQKSVSAWNEPYKGNFGQLMAAKLANPHLKILPSIGGWTLSDPFYFM------ 274 Query: 232 ISDLAFKSNFKLTAKRQDMINGIVTWFDI--VFPAPKGKRP 270 D+ ++ F + K + D+ FP KG P Sbjct: 275 -HDVEKRNVFVDSVKEFLQVWKFFDGVDVDWEFPGGKGANP 314 >5WMM-A nrPDB Length = 926 Score = 28.2 bits (61), Expect = 5.1, Method: Composition-based stats. Identities = 27/124 (21%), Positives = 51/124 (41%), Gaps = 4/124 (3%) Query: 42 RTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMS-SIIEMAKELV 100 +R+++++ + + +L++G G+G+L A + G D S +IE + V Sbjct: 539 EMRRWRDSVVEEVRGLRARRILEIGVGSGLLLGPLAPEAEAY-WGTDFSLPVIERLEVQV 597 Query: 101 ELNGFSDKITLLRGKLEDVH--LPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEG 158 + + LR + DV LP D +I + + + + VL L G Sbjct: 598 GTDPCLKEKVSLRCQHADVADGLPVKYFDTVILNSVVQYFPDAAYLSRVLDVALDRLAPG 657 Query: 159 GLIF 162 G I Sbjct: 658 GRIL 661 >3PT9-A nrPDB Length = 873 Score = 28.2 bits (61), Expect = 5.5, Method: Composition-based stats. Identities = 11/54 (20%), Positives = 19/54 (35%), Gaps = 4/54 (7%) Query: 57 FKDKIVLDVGCGTGILSMFAAKHGAKH-VIGVDMSSIIEMAKELVELNGFSDKI 109 LDV G G LS + G + ++ + + A + LN + Sbjct: 410 LPKLRTLDVFSGCGGLSEGFHQAGISETLWAIE---MWDPAAQAFRLNNPGTTV 460 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.125 0.314 Lambda K H 0.267 0.0385 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,848,061 Number of Sequences: 36641 Number of extensions: 456580 Number of successful extensions: 1761 Number of sequences better than 10.0: 214 Number of HSP's better than 10.0 without gapping: 154 Number of HSP's successfully gapped in prelim test: 160 Number of HSP's that attempted gapping in prelim test: 1463 Number of HSP's gapped (non-prelim): 323 length of query: 348 length of database: 10,336,785 effective HSP length: 98 effective length of query: 250 effective length of database: 6,745,967 effective search space: 1686491750 effective search space used: 1686491750 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.4 bits)