BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P36887 (351 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5N23-A nrPDB 710 0.0 4WB7-A nrPDB 697 0.0 5X3F-B nrPDB 684 0.0 1FOT-A nrPDB 347 4e-96 6BDL-A nrPDB 285 3e-77 2JDO-A nrPDB 268 3e-72 5KCV-A nrPDB 268 3e-72 3MV5-A nrPDB 267 4e-72 3HDN-A nrPDB 264 4e-71 3TXO-A nrPDB 253 1e-67 5FET-A nrPDB 244 3e-65 4L42-A nrPDB 241 4e-64 4RA4-A nrPDB 240 6e-64 5DYK-A nrPDB 239 1e-63 5D9K-A nrPDB 238 2e-63 2Z7Q-A nrPDB 238 3e-63 4CRS-A nrPDB 237 5e-63 1VZO-A nrPDB 236 1e-62 3PFQ-A nrPDB 234 4e-62 4RLP-A nrPDB 233 6e-62 2I0E-A nrPDB 233 8e-62 4OTD-A nrPDB 229 2e-60 3A8W-A nrPDB 227 7e-60 5F9E-A nrPDB 226 9e-60 6E9W-A nrPDB 222 2e-58 6BXI-A nrPDB 217 8e-57 6ED6-A nrPDB 214 4e-56 4AW2-A nrPDB 213 1e-55 3ORZ-A nrPDB 210 7e-55 3TKU-A nrPDB 208 2e-54 5LOH-A nrPDB 197 5e-51 4FR4-A nrPDB 197 7e-51 2VD5-A nrPDB 193 8e-50 3PVW-A nrPDB 191 4e-49 5UUU-A nrPDB 191 4e-49 4CZT-A nrPDB 177 8e-45 3C51-A nrPDB 176 9e-45 2QNJ-A nrPDB 176 1e-44 2JC6-A nrPDB 176 1e-44 5KZ7-A nrPDB 174 7e-44 5ES1-A nrPDB 173 8e-44 4TNB-A nrPDB 172 1e-43 4REW-A nrPDB 171 3e-43 4CFH-A nrPDB 171 6e-43 4RED-A nrPDB 171 6e-43 2JAM-A nrPDB 169 2e-42 4YHJ-A nrPDB 168 4e-42 4C0T-A nrPDB 167 6e-42 5EZV-A nrPDB 166 1e-41 4CFF-A nrPDB 166 1e-41 2YCR-A nrPDB 165 3e-41 4D28-A nrPDB 164 5e-41 5YKS-A nrPDB 164 6e-41 5JZN-A nrPDB 164 6e-41 4FG9-A nrPDB 163 8e-41 3NYO-A nrPDB 163 1e-40 2YZA-A nrPDB 162 2e-40 3I6U-A nrPDB 162 2e-40 2HAK-A nrPDB 162 2e-40 6C9D-A nrPDB 160 6e-40 4YNZ-A nrPDB 159 1e-39 3HZT-A nrPDB 157 4e-39 3DXN-A nrPDB 157 8e-39 4UZD-A nrPDB 156 1e-38 3D2K-A nrPDB 156 1e-38 4CQG-A nrPDB 155 2e-38 4B8L-A nrPDB 155 2e-38 4D2V-A nrPDB 150 7e-37 4NIF-A nrPDB 150 1e-36 3LIJ-A nrPDB 149 2e-36 4JXF-A nrPDB 148 3e-36 4JG6-A nrPDB 148 3e-36 5XZW-A nrPDB 147 5e-36 3MN3-A nrPDB 147 5e-36 5IG1-A nrPDB 147 7e-36 5FG8-A nrPDB 146 1e-35 4AF3-A nrPDB 145 2e-35 2BDW-A nrPDB 144 6e-35 3KK8-A nrPDB 144 8e-35 2Y7J-A nrPDB 143 1e-34 4PDS-A nrPDB 143 1e-34 6CMJ-A nrPDB 142 2e-34 2VN9-A nrPDB 142 3e-34 4MVF-A nrPDB 141 3e-34 5JN2-A nrPDB 141 3e-34 3MA6-A nrPDB 141 5e-34 2V7O-A nrPDB 141 5e-34 4I6B-A nrPDB 140 1e-33 1PHK-A nrPDB 139 1e-33 4RGJ-A nrPDB 139 2e-33 4YZB-A nrPDB 139 2e-33 4J52-A nrPDB 139 2e-33 2OU7-A nrPDB 139 2e-33 6FDY-U nrPDB 139 3e-33 5U6Y-A nrPDB 138 3e-33 4APC-A nrPDB 138 4e-33 3H4J-B nrPDB 138 4e-33 5WAX-A nrPDB 138 4e-33 2VZ6-A nrPDB 137 5e-33 3BHH-A nrPDB 137 5e-33 1NY3-A nrPDB 137 7e-33 2OZA-A nrPDB 137 8e-33 4B6L-A nrPDB 137 9e-33 3Q5I-A nrPDB 135 2e-32 3DB8-A nrPDB 135 3e-32 3UDB-A nrPDB 135 3e-32 3KA0-A nrPDB 135 3e-32 3SOA-A nrPDB 135 4e-32 3ZUT-A nrPDB 134 5e-32 3KN6-A nrPDB 133 1e-31 4LQP-A nrPDB 132 2e-31 3NCG-A nrPDB 132 2e-31 5YV8-A nrPDB 132 2e-31 2W4O-A nrPDB 132 2e-31 3DFA-A nrPDB 131 4e-31 3FXW-A nrPDB 130 1e-30 3UC3-A nrPDB 129 2e-30 3TAC-A nrPDB 125 2e-29 2UV2-A nrPDB 125 4e-29 3F3Z-A nrPDB 124 5e-29 3Q53-A nrPDB 124 7e-29 4WNO-A nrPDB 123 1e-28 6FD3-A nrPDB 122 2e-28 3COM-A nrPDB 122 2e-28 6HXF-B nrPDB 122 3e-28 6CCF-A nrPDB 121 4e-28 4KS7-A nrPDB 120 8e-28 6AO5-A nrPDB 120 1e-27 4LG4-A nrPDB 120 1e-27 2HW6-A nrPDB 119 2e-27 3M42-A nrPDB 117 7e-27 3GUB-A nrPDB 117 8e-27 6QAU-A nrPDB 117 9e-27 2J90-A nrPDB 117 1e-26 2XNP-A nrPDB 115 2e-26 3ZDU-A nrPDB 114 4e-26 2YAB-A nrPDB 114 4e-26 2F57-A nrPDB 114 8e-26 1ZWS-A nrPDB 113 1e-25 2BRG-A nrPDB 113 2e-25 4XBR-A nrPDB 112 2e-25 4FIE-A nrPDB 111 4e-25 2Q0N-A nrPDB 111 4e-25 4JDH-A nrPDB 111 4e-25 2X4F-A nrPDB 110 6e-25 2A27-A nrPDB 110 7e-25 3UTO-A nrPDB 110 9e-25 1KOA-A nrPDB 110 1e-24 2WQN-A nrPDB 108 3e-24 4BGQ-A nrPDB 108 5e-24 6CKI-A nrPDB 107 6e-24 5TQX-A nrPDB 107 6e-24 1KOB-A nrPDB 107 6e-24 3QA8-A nrPDB 107 7e-24 6E2O-A nrPDB 107 1e-23 3DLS-A nrPDB 105 3e-23 3IS5-A nrPDB 105 3e-23 4QMW-A nrPDB 105 3e-23 4X3F-A nrPDB 105 3e-23 4OW8-A nrPDB 104 5e-23 4FZF-B nrPDB 104 5e-23 6B2Q-A nrPDB 104 6e-23 2WTK-C nrPDB 103 9e-23 3LM0-A nrPDB 103 9e-23 4KIK-B nrPDB 103 1e-22 2XIK-A nrPDB 102 2e-22 6CQF-A nrPDB 102 2e-22 4BBM-A nrPDB 101 6e-22 5KKR-C nrPDB 100 7e-22 3EQC-A nrPDB 100 9e-22 3OHT-A nrPDB 99 3e-21 4AN9-A nrPDB 99 3e-21 4EQM-A nrPDB 97 9e-21 1S9I-A nrPDB 97 1e-20 5J5T-A nrPDB 96 3e-20 4EWQ-A nrPDB 95 4e-20 5D7A-A nrPDB 94 6e-20 6GU6-A nrPDB 94 8e-20 4X7Q-B nrPDB 94 8e-20 4AGU-A nrPDB 93 1e-19 1ZXE-A nrPDB 93 2e-19 5ZTN-A nrPDB 93 2e-19 2BPM-A nrPDB 92 2e-19 4IC8-A nrPDB 91 5e-19 5Z33-A nrPDB 91 7e-19 5O2C-A nrPDB 90 1e-18 4ZSG-A nrPDB 90 1e-18 3PPZ-A nrPDB 90 2e-18 4U41-A nrPDB 90 2e-18 5O2B-A nrPDB 89 2e-18 5X8I-B nrPDB 89 2e-18 2XYN-A nrPDB 89 4e-18 1TKI-A nrPDB 88 7e-18 4TPT-A nrPDB 87 8e-18 4PWN-A nrPDB 87 1e-17 2GCD-A nrPDB 87 1e-17 1U5R-A nrPDB 87 1e-17 4MYG-A nrPDB 86 2e-17 4RC3-A nrPDB 86 2e-17 3GC9-A nrPDB 86 2e-17 3BGP-A nrPDB 86 2e-17 3ORP-A nrPDB 86 2e-17 5AWM-A nrPDB 86 3e-17 5B2L-A nrPDB 86 3e-17 4HVI-A nrPDB 86 3e-17 5TUR-A nrPDB 86 3e-17 3OZ6-A nrPDB 85 5e-17 6NPU-A nrPDB 85 5e-17 5AIR-A nrPDB 85 5e-17 3HKO-A nrPDB 85 5e-17 5VD3-A nrPDB 85 6e-17 3DAK-A nrPDB 84 1e-16 1K9A-A nrPDB 84 1e-16 5DBX-A nrPDB 84 1e-16 5HVK-A nrPDB 83 1e-16 3E3P-A nrPDB 83 2e-16 5EFQ-A nrPDB 83 2e-16 4XEY-B nrPDB 83 2e-16 4NST-A nrPDB 82 3e-16 4UY9-A nrPDB 82 3e-16 1UA2-A nrPDB 82 3e-16 1BYG-A nrPDB 82 4e-16 1CM8-A nrPDB 82 4e-16 5X5O-A nrPDB 82 4e-16 2FO0-A nrPDB 82 5e-16 3E7O-A nrPDB 81 7e-16 4CSV-A nrPDB 81 7e-16 5G6V-A nrPDB 81 8e-16 4JLC-A nrPDB 80 1e-15 6NT9-A nrPDB 80 1e-15 4EUU-A nrPDB 80 1e-15 4E7W-A nrPDB 80 1e-15 4EUT-A nrPDB 80 2e-15 3DTC-A nrPDB 80 2e-15 2A1A-B nrPDB 79 2e-15 6O8B-A nrPDB 79 3e-15 4GS6-A nrPDB 79 3e-15 6FYV-A nrPDB 79 3e-15 2WO6-A nrPDB 79 3e-15 2XS0-A nrPDB 79 3e-15 6DTL-A nrPDB 79 3e-15 2I6L-A nrPDB 79 4e-15 1JNK-A nrPDB 78 5e-15 4QNY-A nrPDB 78 5e-15 2F9G-A nrPDB 78 6e-15 3FI2-A nrPDB 78 7e-15 5UNP-A nrPDB 77 8e-15 4G3E-A nrPDB 77 8e-15 4O2Z-A nrPDB 77 8e-15 4QTB-A nrPDB 77 9e-15 5AMN-A nrPDB 77 1e-14 4Y93-A nrPDB 77 1e-14 4XI2-A nrPDB 77 1e-14 5O0Y-A nrPDB 77 1e-14 6E4F-A nrPDB 77 1e-14 3NIZ-A nrPDB 77 2e-14 5CEK-A nrPDB 76 2e-14 5NGU-A nrPDB 76 2e-14 6DC0-A nrPDB 76 2e-14 1V0B-A nrPDB 76 2e-14 5VO2-A nrPDB 76 2e-14 4IDT-A nrPDB 76 3e-14 3UIU-A nrPDB 76 3e-14 3EB0-A nrPDB 76 3e-14 4UYA-A nrPDB 76 3e-14 3SXS-A nrPDB 75 3e-14 3VN9-A nrPDB 75 3e-14 3LLT-A nrPDB 75 4e-14 4KRC-A nrPDB 75 5e-14 2PMN-X nrPDB 75 5e-14 5Y86-A nrPDB 75 6e-14 1G3N-A nrPDB 75 6e-14 3QUP-A nrPDB 74 9e-14 6DBM-A nrPDB 73 2e-13 4E93-A nrPDB 73 2e-13 3FME-A nrPDB 73 2e-13 4YFF-A nrPDB 73 2e-13 5FM2-A nrPDB 73 2e-13 5HIE-A nrPDB 73 2e-13 3IO7-A nrPDB 73 2e-13 2W1I-A nrPDB 72 3e-13 2H34-A nrPDB 72 3e-13 3ALO-A nrPDB 72 4e-13 3A4O-X nrPDB 72 5e-13 5HI2-A nrPDB 72 5e-13 5L2Q-C nrPDB 71 5e-13 4AU8-A nrPDB 71 6e-13 4OLI-A nrPDB 71 7e-13 4Y83-A nrPDB 70 1e-12 3PP0-A nrPDB 70 1e-12 4M66-A nrPDB 69 2e-12 3RAW-A nrPDB 69 2e-12 3CJF-A nrPDB 69 2e-12 4E20-A nrPDB 69 2e-12 6DBN-A nrPDB 69 3e-12 2J0K-A nrPDB 69 3e-12 2DQ7-X nrPDB 69 3e-12 2H8H-A nrPDB 69 3e-12 5SYS-A nrPDB 69 3e-12 4H1J-A nrPDB 69 4e-12 4EBW-A nrPDB 68 5e-12 5GNK-A nrPDB 68 6e-12 2W96-B nrPDB 68 6e-12 2Y6O-A nrPDB 68 6e-12 3LZB-A nrPDB 68 6e-12 6FER-A nrPDB 68 7e-12 3RP9-A nrPDB 68 7e-12 6O6Q-A nrPDB 67 8e-12 1FVR-A nrPDB 67 9e-12 3N9X-A nrPDB 67 1e-11 3G0E-A nrPDB 67 1e-11 6F3F-A nrPDB 67 1e-11 3DKO-A nrPDB 67 2e-11 5TOS-A nrPDB 66 2e-11 2PSQ-A nrPDB 66 2e-11 5EG3-A nrPDB 66 2e-11 4PDO-A nrPDB 66 2e-11 1JPA-A nrPDB 66 2e-11 6GQK-A nrPDB 66 2e-11 3GC0-A nrPDB 66 2e-11 4XCU-A nrPDB 65 4e-11 1U54-B nrPDB 65 5e-11 3MIA-A nrPDB 65 6e-11 1U59-A nrPDB 64 7e-11 4HZS-A nrPDB 64 7e-11 5X02-A nrPDB 64 8e-11 3GQL-A nrPDB 64 8e-11 6CTH-A nrPDB 64 8e-11 3NIE-A nrPDB 64 9e-11 4XUF-A nrPDB 64 9e-11 3OMV-A nrPDB 64 9e-11 5A46-A nrPDB 64 9e-11 4P5Q-A nrPDB 64 1e-10 2JD5-A nrPDB 64 1e-10 4IAN-A nrPDB 64 1e-10 3BBT-B nrPDB 64 1e-10 3TT0-A nrPDB 64 1e-10 3BEA-A nrPDB 64 1e-10 5L6P-A nrPDB 64 1e-10 3ZBF-A nrPDB 63 2e-10 3PLS-A nrPDB 63 2e-10 2OZO-A nrPDB 63 2e-10 4M7I-A nrPDB 63 2e-10 2CMW-A nrPDB 63 2e-10 2HK5-A nrPDB 62 3e-10 2VWV-A nrPDB 62 3e-10 2R2P-A nrPDB 62 3e-10 4NEU-A nrPDB 62 4e-10 2PZI-A nrPDB 62 4e-10 4K33-A nrPDB 62 4e-10 5C26-A nrPDB 62 4e-10 5U6C-A nrPDB 62 4e-10 4FL3-A nrPDB 62 4e-10 3QGY-A nrPDB 62 5e-10 3KUL-B nrPDB 62 5e-10 3V5Q-A nrPDB 62 5e-10 5M07-A nrPDB 61 6e-10 1AD5-A nrPDB 61 8e-10 3HMP-A nrPDB 61 8e-10 4Y12-A nrPDB 61 9e-10 3PG1-A nrPDB 61 9e-10 5WNL-A nrPDB 60 1e-09 5KMM-A nrPDB 60 1e-09 5UIU-A nrPDB 60 1e-09 5MJB-A nrPDB 60 1e-09 6GVJ-A nrPDB 60 1e-09 5GRN-A nrPDB 60 1e-09 4LRM-A nrPDB 60 1e-09 4AT3-A nrPDB 60 1e-09 5WNO-A nrPDB 60 1e-09 6FEX-A nrPDB 59 2e-09 4XLV-A nrPDB 59 2e-09 2OGV-A nrPDB 59 3e-09 5HLW-A nrPDB 59 3e-09 2ZMD-A nrPDB 59 3e-09 5H2U-A nrPDB 59 3e-09 4F0G-A nrPDB 59 3e-09 4CRL-A nrPDB 59 4e-09 4C59-A nrPDB 59 4e-09 5AP3-A nrPDB 59 4e-09 6J5U-C nrPDB 58 5e-09 4NT4-A nrPDB 58 6e-09 5U6B-A nrPDB 58 6e-09 3HNG-A nrPDB 58 6e-09 6EII-A nrPDB 57 8e-09 6HMD-A nrPDB 57 9e-09 5XVU-A nrPDB 57 9e-09 2BUJ-A nrPDB 57 1e-08 6BSD-A nrPDB 57 1e-08 3VHK-A nrPDB 57 1e-08 3LMG-A nrPDB 57 1e-08 5AR8-A nrPDB 57 1e-08 3KRL-A nrPDB 57 1e-08 4MD7-E nrPDB 57 1e-08 4F9B-A nrPDB 57 1e-08 2CHL-A nrPDB 57 1e-08 3C1X-A nrPDB 57 1e-08 2C47-A nrPDB 57 2e-08 4L00-A nrPDB 56 2e-08 2PL0-A nrPDB 56 2e-08 4LFI-A nrPDB 55 3e-08 4R7H-A nrPDB 55 3e-08 5FQD-C nrPDB 55 3e-08 4TN6-A nrPDB 55 3e-08 3I81-A nrPDB 55 4e-08 5IKW-A nrPDB 54 7e-08 5TE0-A nrPDB 54 8e-08 1LUF-A nrPDB 54 9e-08 5X18-A nrPDB 54 1e-07 5VDK-A nrPDB 54 1e-07 2Y4I-B nrPDB 54 1e-07 3SV0-A nrPDB 52 3e-07 2PVN-A nrPDB 52 4e-07 3AOX-A nrPDB 52 4e-07 5VC6-A nrPDB 52 6e-07 3QD2-B nrPDB 51 7e-07 5LPZ-A nrPDB 51 7e-07 3UIM-A nrPDB 51 8e-07 1PY5-A nrPDB 51 9e-07 5LPV-A nrPDB 51 9e-07 3G2F-A nrPDB 51 9e-07 4PL5-B nrPDB 50 1e-06 5OAT-A nrPDB 50 2e-06 5XD6-A nrPDB 49 3e-06 6HV0-A nrPDB 49 4e-06 4XHL-A nrPDB 49 4e-06 6BFN-A nrPDB 49 5e-06 2QKW-B nrPDB 48 6e-06 4RT7-A nrPDB 48 7e-06 5CLR-A nrPDB 48 7e-06 2RIO-A nrPDB 47 1e-05 4XHH-A nrPDB 47 1e-05 3REP-A nrPDB 45 4e-05 3ZZW-A nrPDB 45 4e-05 4BTK-A nrPDB 45 5e-05 4NFN-A nrPDB 45 5e-05 3Q4U-A nrPDB 44 9e-05 2WTK-B nrPDB 44 1e-04 4JRN-A nrPDB 44 1e-04 3MY0-A nrPDB 43 2e-04 3MDY-A nrPDB 42 3e-04 1CSN-A nrPDB 42 3e-04 4WUA-A nrPDB 42 4e-04 3SOC-A nrPDB 41 6e-04 2QLU-A nrPDB 40 0.001 4WOV-A nrPDB 40 0.002 5C01-A nrPDB 40 0.002 3BYV-A nrPDB 39 0.003 5E8V-A nrPDB 39 0.003 2X7G-A nrPDB 37 0.009 6G4J-A nrPDB 37 0.010 6EQI-C nrPDB 37 0.011 5DMZ-A nrPDB 37 0.017 3DZO-A nrPDB 36 0.025 5X1R-A nrPDB 35 0.035 6BHC-A nrPDB 35 0.051 5UU1-A nrPDB 35 0.051 3Q60-A nrPDB 33 0.20 2RSV-A nrPDB 32 0.30 2LAV-A nrPDB 32 0.33 2W1Z-A nrPDB 32 0.34 3C37-A nrPDB 32 0.36 6J6I-B nrPDB 32 0.46 4IX6-A nrPDB 31 0.64 2JII-A nrPDB 31 0.66 2Z8G-A nrPDB 31 0.80 5N28-B nrPDB 30 1.5 5VE6-A nrPDB 30 1.8 5N1Q-B nrPDB 30 1.9 6EWX-A nrPDB 29 2.3 4CWM-A nrPDB 29 2.6 5A8R-B nrPDB 28 4.3 3ENH-A nrPDB 28 6.5 2BMB-A nrPDB 28 8.0 5VH1-A nrPDB 28 8.7 3II0-A nrPDB 27 8.9 5ZJI-4 nrPDB 27 9.9 >5N23-A nrPDB Length = 352 Score = 710 bits (1832), Expect = 0.0, Method: Compositional matrix adjust. Identities = 342/352 (97%), Positives = 348/352 (98%), Gaps = 1/352 (0%) Query: 1 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML 60 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWE+PAQNTAHLDQFERI+TLGTGSFGRVML Sbjct: 1 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVML 60 Query: 61 VKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMV 120 VKHKETGNH+AMKILDKQKVVKLKQIEHTLNEKRI QAVNFPFLVKLE+SFKDNSNLYMV Sbjct: 61 VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMV 120 Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 +EY PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY Sbjct: 121 LEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 Query: 181 IQVTDFGFAKRVKGRT-WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 I+V DFGFAKRVKGRT WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF Sbjct: 181 IKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 240 Query: 240 FADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 FADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA Sbjct: 241 FADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 300 Query: 300 TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351 TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF Sbjct: 301 TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 352 >4WB7-A nrPDB Length = 405 Score = 697 bits (1799), Expect = 0.0, Method: Compositional matrix adjust. Identities = 334/338 (98%), Positives = 337/338 (99%) Query: 14 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK 73 E VKEFLAKAKEDFLKKWE+PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH+AMK Sbjct: 68 EEVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMK 127 Query: 74 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL 133 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE+SFKDNSNLYMVMEYVPGGEMFSHL Sbjct: 128 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHL 187 Query: 134 RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK 193 RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK Sbjct: 188 RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK 247 Query: 194 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS Sbjct: 248 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 307 Query: 254 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA Sbjct: 308 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 367 Query: 314 PFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351 PFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF Sbjct: 368 PFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 405 >5X3F-B nrPDB Length = 393 Score = 684 bits (1764), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/347 (94%), Positives = 338/347 (97%), Gaps = 3/347 (0%) Query: 5 AAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHK 64 A AKK ++ V+ FLAKAKEDFLKKWE P+QNTA LDQF+RIKTLGTGSFGRVMLVKHK Sbjct: 50 AEAKKLND---VQAFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHK 106 Query: 65 ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYV 124 E+GNH+AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE+SFKDNSNLYMVMEYV Sbjct: 107 ESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYV 166 Query: 125 PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184 GGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT Sbjct: 167 AGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 226 Query: 185 DFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP 244 DFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP Sbjct: 227 DFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP 286 Query: 245 IQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI 304 IQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI Sbjct: 287 IQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI 346 Query: 305 AIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351 AIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEF+EF Sbjct: 347 AIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 393 >1FOT-A nrPDB Length = 318 Score = 347 bits (890), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 153/301 (50%), Positives = 221/301 (73%), Gaps = 1/301 (0%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 L F+ ++TLGTGSFGRV L++ + G ++AMK+L K+ VV+LKQ+EHT +E+ +L V Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVT 64 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 PF++++ +F+D ++M+M+Y+ GGE+FS LR+ RF P A+FYAA++ L EYLHS Sbjct: 65 HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHS 124 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 220 D+IYRDLKPEN+L+D+ G+I++TDFGFAK V T+TLCGTP+Y+APE++ +K YNK++ Sbjct: 125 KDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSI 184 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 280 DWW+ G+LIYEM AGY PF+ ++ YEKI++ ++RFP F+ D+KDLL L+ DL++ Sbjct: 185 DWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQ 244 Query: 281 RFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKF-KGPGDTSNFDDYEEEEIRVS 339 R GNL+NG D+KNH WF W + R +E P+ P +G GDTS FD Y EE+I Sbjct: 245 RLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEEDINYG 304 Query: 340 I 340 + Sbjct: 305 V 305 >6BDL-A nrPDB Length = 347 Score = 285 bits (728), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 140/310 (45%), Positives = 199/310 (64%), Gaps = 5/310 (1%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHK-ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 L F I TLG G FGRV LV+ K E FAMKIL K+ +V +Q EH +EK+I+Q Sbjct: 33 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 92 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 + F+V+L +FKD+ LYM+ME GGE+++ LR G F + RFY A +V F YLH Sbjct: 93 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLH 152 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSKGYN 217 S +IYRDLKPENL++D +GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+KG++ Sbjct: 153 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 212 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQ 275 + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP + + +L++ L + Sbjct: 213 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCR 272 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE 335 + ++R GNLKNGV DI+ HKWF +W + + + P IP P DTSNFD + E+ Sbjct: 273 DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDN 332 Query: 336 IRVSINEKCG 345 ++ G Sbjct: 333 DEPPPDDNSG 342 >2JDO-A nrPDB Length = 342 Score = 268 bits (685), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 128/293 (43%), Positives = 187/293 (63%), Gaps = 3/293 (1%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++ F+ +K LG G+FG+V+LV+ K TG ++AMKIL K+ ++ ++ HT+ E R+LQ Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 68 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 PFL L+Y+F+ + L VMEY GGE+F HL R F+E ARFY A+IV EYLHS Sbjct: 69 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 128 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYN 217 D++YRD+K ENL++D+ G+I++TDFG K G T T CGTPEYLAPE++ Y Sbjct: 129 RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYG 188 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 277 +AVDWW LGV++YEM G PF+ +++E I+ ++RFP S + K LL LL+ D Sbjct: 189 RAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKD 248 Query: 278 LTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 +R G + ++ H++F + +W + Q+K+ PF P+ DT FDD Sbjct: 249 PKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDD 301 >5KCV-A nrPDB Length = 460 Score = 268 bits (685), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 133/294 (45%), Positives = 186/294 (63%), Gaps = 4/294 (1%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +++FE +K LG G+FG+V+LVK K TG ++AMKIL K+ +V ++ HTL E R+LQ Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 220 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 PFL L+YSF+ + L VMEY GGE+F HL R FSE ARFY A+IV +YLHS Sbjct: 221 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 280 Query: 161 -LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGY 216 +++YRDLK ENL++D+ G+I++TDFG K G T T CGTPEYLAPE++ Y Sbjct: 281 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 340 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 +AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL LL+ Sbjct: 341 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 400 Query: 277 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 D +R G +I H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 401 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 454 >3MV5-A nrPDB Length = 342 Score = 267 bits (683), Expect = 4e-72, Method: Compositional matrix adjust. Identities = 133/294 (45%), Positives = 186/294 (63%), Gaps = 4/294 (1%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +++FE +K LG G+FG+V+LVK K TG ++AMKIL K+ +V ++ HTL E R+LQ Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 68 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 PFL L+YSF+ + L VMEY GGE+F HL R FSE ARFY A+IV +YLHS Sbjct: 69 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 128 Query: 161 -LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGY 216 +++YRDLK ENL++D+ G+I++TDFG K G T T CGTPEYLAPE++ Y Sbjct: 129 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 188 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 +AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL LL+ Sbjct: 189 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 248 Query: 277 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 D +R G +I H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 249 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 302 >3HDN-A nrPDB Length = 373 Score = 264 bits (675), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 131/313 (41%), Positives = 199/313 (63%), Gaps = 7/313 (2%) Query: 34 PAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 P+ N A F +K +G GSFG+V+L +HK +A+K+L K+ ++K K+ +H ++E Sbjct: 29 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 88 Query: 93 KRIL-QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151 + +L + V PFLV L +SF+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I Sbjct: 89 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 148 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAP 208 YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP Sbjct: 149 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 208 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268 E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ + Sbjct: 209 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 268 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 328 LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P GP D +F Sbjct: 269 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 327 Query: 329 D-DYEEEEIRVSI 340 D ++ EE + +I Sbjct: 328 DPEFTEEPVPNAI 340 >3TXO-A nrPDB Length = 353 Score = 253 bits (645), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 131/315 (41%), Positives = 196/315 (62%), Gaps = 7/315 (2%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + N +D FE I+ LG GSFG+VML + KETG+ +A+K+L K +++ +E T+ EKR Sbjct: 16 SSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKR 75 Query: 95 ILQ-AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 IL A N PFL +L F+ L+ VME+V GG++ H+++ RF E ARFYAA+I+ Sbjct: 76 ILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 135 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEI 210 +LH +IYRDLK +N+L+D +G+ ++ DFG K G T T CGTP+Y+APEI Sbjct: 136 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 195 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 270 + Y AVDWWA+GVL+YEM G+ PF A+ ++E I++ +V +P+ D +L Sbjct: 196 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGIL 255 Query: 271 RNLLQVDLTKRFGNL-KNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 329 ++ + + T R G+L + G + I H +F DW + R++E PF P+ K D SNFD Sbjct: 256 KSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFD 315 Query: 330 -DY-EEEEIRVSINE 342 D+ +EE + I+E Sbjct: 316 PDFIKEEPVLTPIDE 330 >5FET-A nrPDB Length = 847 Score = 244 bits (624), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 118/300 (39%), Positives = 183/300 (61%), Gaps = 3/300 (1%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 + + E + +G G+FG V LV HK T +A+K + K+ ++ L Q + E+ I Sbjct: 530 VEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAE 589 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + PF+++L +FKD++ Y + E V GGE++ +R++G S+P A+FY I+L EYL Sbjct: 590 NDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYL 649 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK 218 H +++YRDLKPEN+L+D+QGY+++ DFG AK+++GR +TL GTP Y+APE+IL KGY Sbjct: 650 HERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGKGYGC 709 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQP--IQIYEKIVSGKVRFPSHFSS-DLKDLLRNLLQ 275 VD WALGV +YE G PF DQ ++I+ I++G++ FP + S D +L++ LL Sbjct: 710 TVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLMKRLLC 769 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEE 335 R G NG DIK H +F +W + R +E P + K + + + EEE+ Sbjct: 770 RLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQIEEED 829 >4L42-A nrPDB Length = 346 Score = 241 bits (615), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 118/293 (40%), Positives = 175/293 (59%), Gaps = 7/293 (2%) Query: 44 FERIKTLGTGSFGRVMLVKH---KETGNHFAMKILDKQKVVK-LKQIEHTLNEKRILQAV 99 FE ++ LG G +G+V V+ TG FAMK+L K +V+ K HT E+ IL+ V Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 PF+V L Y+F+ LY+++EY+ GGE+F L R G F E A FY A+I + +LH Sbjct: 80 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 139 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGY 216 +IYRDLKPEN++++ QG++++TDFG K T T CGT EY+APEI++ G+ Sbjct: 140 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGH 199 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 N+AVDWW+LG L+Y+M G PPF + + +KI+ K+ P + + + +DLL+ LL+ Sbjct: 200 NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKR 259 Query: 277 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 329 + R G +++ H +F +W + RKVE PF P + D S FD Sbjct: 260 NAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD 312 >4RA4-A nrPDB Length = 355 Score = 240 bits (613), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 123/306 (40%), Positives = 182/306 (59%), Gaps = 7/306 (2%) Query: 32 ENPAQNT--AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT 89 + P+ N L F + LG GSFG+VML K T +A+KIL K V++ +E T Sbjct: 8 KQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECT 67 Query: 90 LNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148 + EKR+L ++ PFL +L F+ LY VMEYV GG++ H++++G+F EP A FYA Sbjct: 68 MVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYA 127 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKG-RTWTLCGTPEY 205 A+I + +LH +IYRDLK +N+++D +G+I++ DFG K + G T T CGTP+Y Sbjct: 128 AEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDY 187 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSD 265 +APEII + Y K+VDWWA GVL+YEM AG PPF + ++++ I+ V +P S + Sbjct: 188 IAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKE 247 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDT 325 + + L+ KR G G D++ H +F DW + R+++ PF PK G G Sbjct: 248 AVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKG-A 306 Query: 326 SNFDDY 331 NFD + Sbjct: 307 ENFDKF 312 >5DYK-A nrPDB Length = 853 Score = 239 bits (610), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 112/283 (39%), Positives = 178/283 (62%), Gaps = 3/283 (1%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 +D+ E + +G G+FG V LV HK T +A+K + K+ ++ L Q + E+ I Sbjct: 536 VEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAE 595 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + PF+++L +FKD+ Y + E V GGE++ +R++G S+ A+FY I+L EYL Sbjct: 596 NDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYL 655 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK 218 H +++YRDLKPEN+L+D+QGY+++ DFG AK+V+GR +TL GTP Y+APE+IL KGY Sbjct: 656 HERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKGYGC 715 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQP--IQIYEKIVSGKVRFPSHFS-SDLKDLLRNLLQ 275 VD WALG+ +YE G PF D+ ++I+ I++G++ FP + + +D +L++ LL Sbjct: 716 TVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKRLLC 775 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 318 R G NG DIK+H +F+ +W + R ++ P + K Sbjct: 776 RLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSK 818 >5D9K-A nrPDB Length = 330 Score = 238 bits (608), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 118/294 (40%), Positives = 186/294 (63%), Gaps = 9/294 (3%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNH----FAMKILDKQKVVKLKQIEHTLNEKRILQA 98 QFE +K LG GSFG+V LVK K +G+ +AMK+L K+ +K++ T E+ IL Sbjct: 31 QFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVE 88 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 VN PF+VKL Y+F+ LY++++++ GG++F+ L + F+E +FY A++ L ++L Sbjct: 89 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 148 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKG 215 HSL +IYRDLKPEN+L+D++G+I++TDFG +K + + ++ CGT EY+APE++ +G Sbjct: 149 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRG 208 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 275 + ++ DWW+ GVL++EM G PF + I+ K+ P S + + LLR L + Sbjct: 209 HTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFK 268 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 329 + R G +GV +IK H +F+T DW +Y+R++ PF P P DT FD Sbjct: 269 RNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFD 322 >2Z7Q-A nrPDB Length = 321 Score = 238 bits (607), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 113/293 (38%), Positives = 187/293 (63%), Gaps = 7/293 (2%) Query: 43 QFERIKTLGTGSFGRVMLVK---HKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 FE +K LG GSFG+V LV+ ++G+ +AMK+L K+ +K++ T E+ IL V Sbjct: 29 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILADV 87 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 N PF+VKL Y+F+ LY++++++ GG++F+ L + F+E +FY A++ L ++LH Sbjct: 88 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 147 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGY 216 SL +IYRDLKPEN+L+D++G+I++TDFG +K + + ++ CGT EY+APE++ +G+ Sbjct: 148 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 207 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 + + DWW+ GVL++EM G PF + I+ K+ P S++ + LLR L + Sbjct: 208 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 267 Query: 277 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 329 + R G+ +G +IK H +++T DW +Y+R+++ PF P P DT FD Sbjct: 268 NPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 320 >4CRS-A nrPDB Length = 341 Score = 237 bits (605), Expect = 5e-63, Method: Compositional matrix adjust. Identities = 125/297 (42%), Positives = 179/297 (60%), Gaps = 7/297 (2%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 +L F L G FG+V+L ++K T FA+K L K +V +++ + EKRI + V Sbjct: 10 NLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 69 Query: 100 N---FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 N PFLV L F+ ++ VMEY GG++ H+ FSEP A FYAA +VL + Sbjct: 70 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVVLGLQ 128 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILS 213 YLH ++YRDLK +NLL+D +G++++ DFG K G RT T CGTPE+LAPE++ Sbjct: 129 YLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE 188 Query: 214 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 Y +AVDWW LGVLIYEM G PF D ++++ IV+ +VR+P S++ ++R L Sbjct: 189 TSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRL 248 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 L+ + +R G + D+K H +F DW A+ +KV+ PFIP +G D SNFDD Sbjct: 249 LRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDD 305 >1VZO-A nrPDB Length = 355 Score = 236 bits (602), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 121/303 (39%), Positives = 185/303 (61%), Gaps = 15/303 (4%) Query: 41 LDQFERIKTLGTGSFGRVMLVKH---KETGNHFAMKILDKQKVV-KLKQIEHTLNEKRIL 96 ++ FE +K LGTG++G+V LV+ +TG +AMK+L K +V K K EHT E+++L Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 97 QAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 + + PFLV L Y+F+ + L+++++Y+ GGE+F+HL + RF+E + Y +IVL Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 172 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEII 211 E+LH L +IYRD+K EN+L+D G++ +TDFG +K R + CGT EY+AP+I+ Sbjct: 173 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIV 232 Query: 212 LS--KGYNKAVDWWALGVLIYEMAAGYPPFFAD----QPIQIYEKIVSGKVRFPSHFSSD 265 G++KAVDWW+LGVL+YE+ G PF D +I +I+ + +P S+ Sbjct: 233 RGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSAL 292 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDT 325 KDL++ LL D KR G ++IK H +F +W + +KV APF P + D Sbjct: 293 AKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDV 352 Query: 326 SNF 328 SNF Sbjct: 353 SNF 355 >3PFQ-A nrPDB Length = 674 Score = 234 bits (597), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 121/303 (39%), Positives = 179/303 (59%), Gaps = 5/303 (1%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 N ++ L F + LG GSFG+VML + K T +A+KIL K V++ +E T+ E Sbjct: 332 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 391 Query: 93 KRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151 KR+L PFL +L F+ LY VMEYV GG++ H++++GRF EPHA FYAA+I Sbjct: 392 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 451 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAP 208 + +L S +IYRDLK +N+++D +G+I++ DFG K T T CGTP+Y+AP Sbjct: 452 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 511 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268 EII + Y K+VDWWA GVL+YEM AG PF + ++++ I+ V +P S + Sbjct: 512 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 571 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 328 + + L+ KR G G DIK H +F DW + +++++ P+ PK G + NF Sbjct: 572 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASG-RNAENF 630 Query: 329 DDY 331 D + Sbjct: 631 DRF 633 >4RLP-A nrPDB Length = 288 Score = 233 bits (595), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 114/283 (40%), Positives = 171/283 (60%), Gaps = 7/283 (2%) Query: 42 DQFERIKTLGTGSFGRVMLVKH---KETGNHFAMKILDKQKVVK-LKQIEHTLNEKRILQ 97 + FE ++ LG G +G+V V+ TG FAMK+L K +V+ K HT E+ IL+ Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 V PF+V L Y+F+ LY+++EY+ GGE+F L R G F E A FY A+I + + Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 124 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSK 214 LH +IYRDLKPEN++++ QG++++TDFG K T T CGT EY+APEI++ Sbjct: 125 LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 184 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLL 274 G+N+AVDWW+LG L+Y+M G PPF + + +KI+ K+ P + + + +DLL+ LL Sbjct: 185 GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLL 244 Query: 275 QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 317 + + R G +++ H +F +W + RKVE PF P Sbjct: 245 KRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >2I0E-A nrPDB Length = 353 Score = 233 bits (594), Expect = 8e-62, Method: Compositional matrix adjust. Identities = 121/303 (39%), Positives = 179/303 (59%), Gaps = 5/303 (1%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 N ++ L F + LG GSFG+VML + K T +A+KIL K V++ +E T+ E Sbjct: 11 NGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 70 Query: 93 KRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151 KR+L PFL +L F+ LY VMEYV GG++ H++++GRF EPHA FYAA+I Sbjct: 71 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 130 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAP 208 + +L S +IYRDLK +N+++D +G+I++ DFG K T T CGTP+Y+AP Sbjct: 131 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAP 190 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268 EII + Y K+VDWWA GVL+YEM AG PF + ++++ I+ V +P S + Sbjct: 191 EIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVA 250 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 328 + + L+ KR G G DIK H +F DW + +++++ P+ PK G + NF Sbjct: 251 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG-RNAENF 309 Query: 329 DDY 331 D + Sbjct: 310 DRF 312 >4OTD-A nrPDB Length = 341 Score = 229 bits (583), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 121/296 (40%), Positives = 180/296 (60%), Gaps = 7/296 (2%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 L+ F+ + LG G FG+V+L + + +G FA+K L K +V ++E + EKRIL AV Sbjct: 11 LEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVT 70 Query: 101 ---FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 PFLV L F+ ++ VMEY GG++ H+ FSEP A FY+A +VL ++ Sbjct: 71 SAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQF 129 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSK 214 LH ++YRDLK +NLL+D +GY+++ DFG K G RT T CGTPE+LAPE++ Sbjct: 130 LHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDT 189 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLL 274 Y +AVDWW LGVL+YEM G PF D ++++ IV+ +VR+P S++ ++R LL Sbjct: 190 SYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLL 249 Query: 275 QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 + + +R G+ + D+K +F T W A+ R++ PF+P G D SNFD+ Sbjct: 250 RRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 305 >3A8W-A nrPDB Length = 345 Score = 227 bits (578), Expect = 7e-60, Method: Compositional matrix adjust. Identities = 121/309 (39%), Positives = 181/309 (58%), Gaps = 14/309 (4%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 A + L F+ ++ +G GS+ +V+LV+ K+T +AMK++ K+ V + I+ EK Sbjct: 2 AMDPLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKH 61 Query: 95 IL-QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 + QA N PFLV L F+ S L+ V+EYV GG++ H++R + E HARFY+A+I L Sbjct: 62 VFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISL 121 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAPEI 210 YLH +IYRDLK +N+L+D +G+I++TD+G K R T T CGTP Y+APEI Sbjct: 122 ALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEI 181 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQ-----IYEKIVSGKVRFPSH 261 + + Y +VDWWALGVL++EM AG PF +D P Q +++ I+ ++R P Sbjct: 182 LRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRS 241 Query: 262 FSSDLKDLLRNLLQVDLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFK 320 S +L++ L D +R G + + G DI+ H +F DW + Q++V PF P Sbjct: 242 LSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNIS 301 Query: 321 GPGDTSNFD 329 G NFD Sbjct: 302 GEFGLDNFD 310 >5F9E-A nrPDB Length = 353 Score = 226 bits (577), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 122/318 (38%), Positives = 184/318 (57%), Gaps = 10/318 (3%) Query: 32 ENPA-QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 E P+ Q ++ FE K LG GSFG+V L + K+T FA+K L K V+ +E T+ Sbjct: 8 ERPSLQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTM 67 Query: 91 NEKRILQ-AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149 EKR+L A PFL + +F+ NL+ VMEY+ GG++ H++ +F A FYAA Sbjct: 68 VEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAA 127 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYL 206 +I+L ++LHS ++YRDLK +N+L+D+ G+I++ DFG K +T CGTP+Y+ Sbjct: 128 EIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYI 187 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL 266 APEI+L + YN +VDWW+ GVL+YEM G PF +++ I +P + Sbjct: 188 APEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEA 247 Query: 267 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTS 326 KDLL L + KR G DI+ H F +W + +++++ PF PK K P D S Sbjct: 248 KDLLVKLFVREPEKRLG----VRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCS 303 Query: 327 NFD-DYEEEEIRVSINEK 343 NFD ++ E+ R+S ++ Sbjct: 304 NFDKEFLNEKPRLSFADR 321 >6E9W-A nrPDB Length = 443 Score = 222 bits (565), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 118/327 (36%), Positives = 189/327 (57%), Gaps = 14/327 (4%) Query: 22 KAKEDFLKKWENPAQNTAHL----DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK 77 K ++FL ++++ L + +E +K +G G+FG V LV+HK T +AMK+L K Sbjct: 78 KNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSK 137 Query: 78 QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG 137 +++K E+ I+ N P++V+L Y+F+D+ LYMVMEY+PGG++ + + Sbjct: 138 FEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD 197 Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW 197 E ARFY A++VL + +HS+ I+RD+KP+N+L+D+ G++++ DFG ++ Sbjct: 198 -VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGM 256 Query: 198 TLC----GTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE 249 C GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD + Y Sbjct: 257 VRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYS 316 Query: 250 KIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL-KNGVNDIKNHKWFATTDWIAIYQ 308 KI++ K +D+ +NL+ LT R L +NGV +IK H +F W Sbjct: 317 KIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETL 376 Query: 309 RKVEAPFIPKFKGPGDTSNFDDYEEEE 335 R AP +P DTSNFDD EE++ Sbjct: 377 RDTVAPVVPDLSSDIDTSNFDDLEEDK 403 >6BXI-A nrPDB Length = 333 Score = 217 bits (552), Expect = 8e-57, Method: Compositional matrix adjust. Identities = 119/333 (35%), Positives = 187/333 (56%), Gaps = 47/333 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 L+ FE +K +G G+FG V LV+ K+TG+ +AMKIL K +++ +Q+ H E+ IL + Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 ++VK+ YSF+D NLY++ME++PGG+M + L + +E +FY A+ VL + +H Sbjct: 65 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 124 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFA-----------------------------KR 191 L I+RD+KP+NLL+D +G+++++DFG + Sbjct: 125 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 184 Query: 192 VKGRTW---------TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 242 K TW + GTP+Y+APE+ + GYNK DWW+LGV++YEM GYPPF ++ Sbjct: 185 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 244 Query: 243 QPIQIYEKIVSGK--VRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 P + Y+K+++ K + FP S KDL+ + R G GV +IK++ +F Sbjct: 245 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFC-CEWEHRIG--APGVEEIKSNSFF 301 Query: 299 ATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331 DW I +R A + K DTSNFD++ Sbjct: 302 EGVDWEHIRERP--AAISIEIKSIDDTSNFDEF 332 >6ED6-A nrPDB Length = 415 Score = 214 bits (545), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 113/327 (34%), Positives = 191/327 (58%), Gaps = 14/327 (4%) Query: 22 KAKEDFLKKWENPAQNTAHL----DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK 77 K ++FL ++E + L + ++ +K +G G+FG V LV+HK + +AMK+L K Sbjct: 64 KNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSK 123 Query: 78 QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG 137 +++K E+ I+ N P++V+L Y+F+D+ LYMVMEY+PGG++ + + Sbjct: 124 FEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD 183 Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW 197 E A+FY A++VL + +HS+ LI+RD+KP+N+L+D+ G++++ DFG ++ Sbjct: 184 -VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGM 242 Query: 198 TLC----GTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE 249 C GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD + Y Sbjct: 243 VHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYS 302 Query: 250 KIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL-KNGVNDIKNHKWFATTDWIAIYQ 308 KI+ K +++ +NL+ LT R L +NGV +I+ H +F W Sbjct: 303 KIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNI 362 Query: 309 RKVEAPFIPKFKGPGDTSNFDDYEEEE 335 R+ AP +P+ D+SNFDD E+++ Sbjct: 363 RETAAPVVPELSSDIDSSNFDDIEDDK 389 >4AW2-A nrPDB Length = 437 Score = 213 bits (542), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 119/320 (37%), Positives = 186/320 (58%), Gaps = 25/320 (7%) Query: 30 KWENP-----AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLK 84 +W P Q H + FE +K +G G+FG V +VK K FAMKIL+K +++K Sbjct: 57 EWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRA 116 Query: 85 QIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPH 143 + E+ +L + ++ L Y+F+D++NLY+VM+Y GG++ + L + R E Sbjct: 117 ETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEM 176 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV----KGRTWTL 199 ARFY A++V+ + +H L ++RD+KP+N+L+D G+I++ DFG ++ ++ Sbjct: 177 ARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVA 236 Query: 200 CGTPEYLAPEIILS----KG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254 GTP+Y++PEI+ + KG Y DWW+LGV +YEM G PF+A+ ++ Y KI++ Sbjct: 237 VGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 296 Query: 255 KVRFP-----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQR 309 K RF + S + KDL+R L+ R G +NG+ D K H +F+ DW I R Sbjct: 297 KERFQFPTQVTDVSENAKDLIRRLI-CSREHRLG--QNGIEDFKKHPFFSGIDWDNI--R 351 Query: 310 KVEAPFIPKFKGPGDTSNFD 329 EAP+IP+ P DTSNFD Sbjct: 352 NCEAPYIPEVSSPTDTSNFD 371 >3ORZ-A nrPDB Length = 316 Score = 210 bits (535), Expect = 7e-55, Method: Compositional matrix adjust. Identities = 103/274 (37%), Positives = 164/274 (59%), Gaps = 6/274 (2%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + F+ K LG GSF V+L + T +A+KIL+K+ ++K ++ + E+ ++ ++ Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 PF VKL + F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216 +I+RDLKPEN+L+++ +IQ+TDFG AK + + R + GT +Y++PE++ K Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 216 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL + Sbjct: 217 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 276 Query: 277 DLTKRFGNLK-NGVNDIKNHKWFATTDWIAIYQR 309 D TKR G + G +K H +F + W ++Q+ Sbjct: 277 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 310 >3TKU-A nrPDB Length = 433 Score = 208 bits (530), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 114/305 (37%), Positives = 182/305 (59%), Gaps = 20/305 (6%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 H + FE IK +G G+FG V +VK K T +AMKIL+K +++K + E+ +L Sbjct: 88 HREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG 147 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYL 158 + ++ L Y+F+D ++LY+VM+Y GG++ + L + + E ARFY ++VL + + Sbjct: 148 DCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSI 207 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEII--L 212 H L ++RD+KP+N+L+D G+I++ DFG ++ ++ GTP+Y++PEI+ + Sbjct: 208 HQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAM 267 Query: 213 SKG---YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSH---FSS 264 G Y DWW+LGV +YEM G PF+A+ ++ Y KI++ + R FPSH S Sbjct: 268 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSE 327 Query: 265 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGD 324 + KDL++ L+ +R G +NG+ D K H +F +W I R +EAP+IP P D Sbjct: 328 EAKDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSD 382 Query: 325 TSNFD 329 TSNFD Sbjct: 383 TSNFD 387 >5LOH-A nrPDB Length = 341 Score = 197 bits (501), Expect = 5e-51, Method: Compositional matrix adjust. Identities = 106/301 (35%), Positives = 170/301 (56%), Gaps = 21/301 (6%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +++F +K + G+FG+V L ++ G +A+K++ K ++ E+ L Sbjct: 35 IEEFSIVKPISRGAFGKVYL--GQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 PF+V L YS + +N+Y+VMEY+ GG++ S L G F E A Y +++ L +YLH Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 152 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---------TWTLCGTPEYLAPEII 211 +I+RDLKP+N+LI +G+I++TDFG +K R T T CGTP+YLAPE++ Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELL 212 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP---SHFSSDLKD 268 L + + AVDWWALGV ++E G PPF + P Q+++ I+ + +P S + + Sbjct: 213 LGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQS 272 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 328 + LL +D TKR G+ ++K H F+ DW + + + PFIP+ DTS F Sbjct: 273 AVEILLTIDDTKR-----AGMKELKRHPLFSDVDWENLQHQTM--PFIPQPDDETDTSYF 325 Query: 329 D 329 + Sbjct: 326 E 326 >4FR4-A nrPDB Length = 384 Score = 197 bits (500), Expect = 7e-51, Method: Compositional matrix adjust. Identities = 97/287 (33%), Positives = 173/287 (60%), Gaps = 12/287 (4%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 + D FE ++ +G GSFG+V +V+ +T +AMK ++KQK V+ ++ + E +I+Q Sbjct: 12 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 71 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + PFLV L YSF+D +++MV++ + GG++ HL++ F E + + ++V+ +YL Sbjct: 72 LEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYL 131 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSK-- 214 + +I+RD+KP+N+L+D+ G++ +TDF A + T T+ GT Y+APE+ S+ Sbjct: 132 QNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKG 191 Query: 215 -GYNKAVDWWALGVLIYEMAAGYPPFF---ADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 270 GY+ AVDWW+LGV YE+ G P+ + +I + V +PS +S ++ LL Sbjct: 192 AGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLL 251 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 317 + LL+ + +RF L +D++N + +W A++Q+++ FIP Sbjct: 252 KKLLEPNPDQRFSQL----SDVQNFPYMNDINWDAVFQKRLIPGFIP 294 >2VD5-A nrPDB Length = 412 Score = 193 bits (491), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 123/352 (34%), Positives = 187/352 (53%), Gaps = 38/352 (10%) Query: 10 GSEQESVKEFLAKAK--EDFLKKWENPA-----QNTAHLDQFERIKTLGTGSFGRVMLVK 62 G QE LA+ K DFL+ W P + D FE +K +G G+F V +VK Sbjct: 23 GVHQELGASELAQDKYVADFLQ-WAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVK 81 Query: 63 HKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVME 122 K+TG +AMKI++K ++K ++ E+ +L + ++ +L ++F+D + LY+VME Sbjct: 82 MKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME 141 Query: 123 YVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI 181 Y GG++ + L + G R ARFY A+IV+ + +H L ++RD+KP+N+L+D+ G+I Sbjct: 142 YYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHI 201 Query: 182 QVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILS-------KGYNKAVDWWALGVLIY 230 ++ DFG +++ R+ GTP+YL+PEI+ + Y DWWALGV Y Sbjct: 202 RLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAY 261 Query: 231 EMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL---------KDLLRNLLQVDLTKR 281 EM G PF+AD + Y KI V + H S L +D ++ LL T R Sbjct: 262 EMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPET-R 316 Query: 282 FGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333 G + G D + H +F DW + R PF P F+G DT NFD E+ Sbjct: 317 LG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGATDTCNFDLVED 364 >3PVW-A nrPDB Length = 695 Score = 191 bits (485), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 108/321 (33%), Positives = 181/321 (56%), Gaps = 15/321 (4%) Query: 30 KWENPAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 +W+N N ++ F + +G G FG V + +TG +AMK LDK+++ K+KQ E Sbjct: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 234 Query: 89 -TLNEKRILQAV---NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA 144 LNE+ +L V + PF+V + Y+F L +++ + GG++ HL + G FSE Sbjct: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM 294 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTP 203 RFYAA+I+L E++H+ ++YRDLKP N+L+D+ G+++++D G A K + GT Sbjct: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH 354 Query: 204 EYLAPEIILSKG--YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE---KIVSGKVRF 258 Y+APE +L KG Y+ + DW++LG +++++ G+ PF + +E ++ V Sbjct: 355 GYMAPE-VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 Query: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 318 P FS +L+ LL LLQ D+ +R G L G ++K +F + DW ++ +K P IP Sbjct: 414 PDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473 Query: 319 FKGPGDTSNFD--DYEEEEIR 337 FD ++EE+ + Sbjct: 474 RGEVNAADAFDIGSFDEEDTK 494 >5UUU-A nrPDB Length = 547 Score = 191 bits (485), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 110/334 (32%), Positives = 186/334 (55%), Gaps = 15/334 (4%) Query: 17 KEFLAKAKEDFLKKWENPAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL 75 ++F+ K +W+N N ++ F + +G G FG V + +TG +AMK L Sbjct: 172 QKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL 231 Query: 76 DKQKVVKLKQIEH-TLNEKRILQAV---NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 DK+++ K+KQ E LNE+ +L V + PF+V + Y+F L +++ + GG++ Sbjct: 232 DKKRI-KMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHY 290 Query: 132 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191 HL + G FSE RFYAA+I+L E++H+ ++YRDLKP N+L+D+ G+++++D G A Sbjct: 291 HLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD 350 Query: 192 V-KGRTWTLCGTPEYLAPEIILSKG--YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY 248 K + GT Y+APE +L KG Y+ + DW++LG +++++ G+ PF + + Sbjct: 351 FSKKKPHASVGTHGYMAPE-VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH 409 Query: 249 E---KIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIA 305 E ++ V P FS +L+ LL LLQ D+ +R G L G ++K +F + DW Sbjct: 410 EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQM 469 Query: 306 IYQRKVEAPFIPKFKGPGDTSNFD--DYEEEEIR 337 ++ +K P IP FD ++EE+ + Sbjct: 470 VFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 503 >4CZT-A nrPDB Length = 464 Score = 177 bits (448), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 88/250 (35%), Positives = 143/250 (57%), Gaps = 6/250 (2%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 + ++E +TLG G+F +V ++ E G++ A+K++DK+KV+K K I E ++ Sbjct: 8 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKL 67 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + P ++++ + +Y V+E+V GGE+F + GR E AR Y Q++ +Y Sbjct: 68 IKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 127 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----RVKGRTWTLCGTPEYLAPEIILS 213 HS + +RDLKPENLL+D G ++V+DFG + R G T CGTP Y+APE+I + Sbjct: 128 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 187 Query: 214 KGYNKA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 KGY+ A D W+ GV+++ + AGY PF +Y+KI + P FS+ K L++ Sbjct: 188 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKR 247 Query: 273 LLQVDLTKRF 282 +L + R Sbjct: 248 ILDPNPATRI 257 >3C51-A nrPDB Length = 543 Score = 176 bits (447), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 105/287 (36%), Positives = 162/287 (56%), Gaps = 11/287 (3%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D F + LG G FG V + K TG +A K L+K+++ K K + + EK+IL V+ Sbjct: 185 DWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHS 244 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR----FSEPHARFYAAQIVLTFEY 157 F+V L Y+F+ ++L +VM + GG++ H+ + F EP A FY AQIV E+ Sbjct: 245 RFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEH 304 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GRTWT--LCGTPEYLAPEIILSK 214 LH ++IYRDLKPEN+L+D G ++++D G A +K G+T T GTP ++APE++L + Sbjct: 305 LHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGE 364 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFAD----QPIQIYEKIVSGKVRFPSHFSSDLKDLL 270 Y+ +VD++ALGV +YEM A PF A + ++ ++++ V +P FS KD Sbjct: 365 EYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFC 424 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 317 LLQ D KR G + ++ H F W + + PF+P Sbjct: 425 EALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVP 471 >2QNJ-A nrPDB Length = 328 Score = 176 bits (446), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 106/311 (34%), Positives = 168/311 (54%), Gaps = 19/311 (6%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 H+ + +KT+G G+F +V L +H TG A+KI+DK ++ ++ E RI++ + Sbjct: 10 HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKIL 68 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 N P +VKL + LY++MEY GGE+F +L GR E AR QIV +Y H Sbjct: 69 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 128 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 +++RDLK ENLL+D I++ DFGF+ V G+ T CG+P Y APE+ K Y+ Sbjct: 129 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 188 Query: 218 KA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D ++LL+ L + Sbjct: 189 GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVL 248 Query: 277 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD-----DY 331 + KR G L+ + D +W A ++ PF+ D D Y Sbjct: 249 NPIKR-GTLEQIMKD----RWIN-----AGHEEDELKPFVEPELDISDQKRIDIMVGMGY 298 Query: 332 EEEEIRVSINE 342 +EEI+ S+++ Sbjct: 299 SQEEIQESLSK 309 >2JC6-A nrPDB Length = 334 Score = 176 bits (446), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 102/290 (35%), Positives = 165/290 (56%), Gaps = 20/290 (6%) Query: 20 LAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQK 79 +A+ + W+ A++ + FE +TLGTG+F V+L + K TG FA+K + K+ Sbjct: 2 MARENGESSSSWKKQAEDIKKI--FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKA 59 Query: 80 VVKLKQIEHTL-NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR 138 LK E ++ NE +L+ + +V LE ++ ++LY+VM+ V GGE+F + G Sbjct: 60 ---LKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGF 116 Query: 139 FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAK-RVKG 194 ++E A Q++ YLH + +++RDLKPENLL D++ I ++DFG +K KG Sbjct: 117 YTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKG 176 Query: 195 RTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253 T CGTP Y+APE++ K Y+KAVD W++GV+ Y + GYPPF+ + +++E+I+ Sbjct: 177 DVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILK 236 Query: 254 GKVRFPSHFSSDL----KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 + F S + D+ KD +RNL++ D KR+ H W A Sbjct: 237 AEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRY-----TCEQAARHPWIA 281 >5KZ7-A nrPDB Length = 346 Score = 174 bits (440), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 109/321 (33%), Positives = 171/321 (53%), Gaps = 16/321 (4%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 A H+ + +KT+G G+F +V L +H TG A+KI+DK ++ ++ E R Sbjct: 26 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVR 84 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 I++ +N P +VKL + LY+VMEY GGE+F +L GR E AR QIV Sbjct: 85 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 144 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIIL 212 +Y H +++RDLK ENLL+D I++ DFGF+ + T CG+P Y APE+ Sbjct: 145 VQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQ 204 Query: 213 SKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 K Y+ VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D ++LL+ Sbjct: 205 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 264 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD- 330 L ++ +KR G L+ + D +W + VE +P +K P T Sbjct: 265 KFLILNPSKR-GTLEQIMKD----RWMNVGHEDDELKPYVEP--LPDYKDPRRTELMVSM 317 Query: 331 -YEEEEIRVSINEKCGKEFSE 350 Y EEI+ S+ G+ ++E Sbjct: 318 GYTREEIQDSL---VGQRYNE 335 >5ES1-A nrPDB Length = 328 Score = 173 bits (439), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 104/313 (33%), Positives = 166/313 (53%), Gaps = 21/313 (6%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 H+ + ++T+G G+F +V L +H TG A+KI+DK ++ ++ E RI++ + Sbjct: 13 HVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLFREVRIMKGL 71 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 N P +VKL + LY+VMEY GE+F +L GR E AR QIV Y H Sbjct: 72 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 131 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 ++++RDLK ENLL+D + I++ DFGF+ + + T CG+P Y APE+ K Y+ Sbjct: 132 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 191 Query: 218 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D + +LR L + Sbjct: 192 GPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVL 251 Query: 277 DLTKRFGNLKNGVNDIKNHKWFATTDWIAI-YQRKVEAPFIPKFKGPGDTSNFD-----D 330 + KR L+ + D WI I Y+ + P+ + GDT + Sbjct: 252 NPAKRC-TLEQIMKD----------KWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMG 300 Query: 331 YEEEEIRVSINEK 343 Y EEI+ S+ + Sbjct: 301 YTREEIKESLTSQ 313 >4TNB-A nrPDB Length = 590 Score = 172 bits (437), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 99/316 (31%), Positives = 168/316 (53%), Gaps = 16/316 (5%) Query: 14 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK 73 E E+L D +W+ + + F + + LG G FG V + + TG +A K Sbjct: 156 EPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK 215 Query: 74 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL 133 L+K+++ K K LNEK+IL+ VN F+V L Y+++ L +V+ + GG++ H+ Sbjct: 216 RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275 Query: 134 RRIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191 +G F E A FYAA+I+ E LH + +YRDLKPEN+L+D G+I+++D G A + Sbjct: 276 YNMGNPGFEEERALFYAAEILCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 Query: 192 ------VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 245 ++GR GT Y+APE++ ++ Y + D+W LG LIYEM G PF + Sbjct: 336 IPEGDLIRGRV----GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK 391 Query: 246 ----QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 ++ +++ + + FS + K + + LL D +R G + ++K H +F Sbjct: 392 VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNM 451 Query: 302 DWIAIYQRKVEAPFIP 317 ++ + ++ PF+P Sbjct: 452 NFKRLEAGMLDPPFVP 467 >4REW-A nrPDB Length = 540 Score = 171 bits (434), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 101/304 (33%), Positives = 160/304 (52%), Gaps = 24/304 (7%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 TLG G+FG+V + KH+ TG+ A+KIL++QK+ L + E + L+ P ++KL Sbjct: 13 TLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 72 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 S+++MVMEYV GGE+F ++ + GR E +R QI+ +Y H +++RDL Sbjct: 73 QVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDL 132 Query: 169 KPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGY-NKAVDWWAL 225 KPEN+L+D ++ DFG + + + T CG+P Y APE+I + Y VD W+ Sbjct: 133 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSS 192 Query: 226 GVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL 285 GV++Y + G PF D +++KI G P + + + LL+++LQVD KR Sbjct: 193 GVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKR---- 248 Query: 286 KNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEK-- 343 + DI+ H+WF +PK+ P D S ++E + EK Sbjct: 249 -ASIKDIREHEWFKQD--------------LPKYLFPEDPSYSSTMIDDEALKEVCEKFE 293 Query: 344 CGKE 347 C +E Sbjct: 294 CSEE 297 >4CFH-A nrPDB Length = 493 Score = 171 bits (432), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 101/304 (33%), Positives = 160/304 (52%), Gaps = 24/304 (7%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 TLG G+FG+V + KH+ TG+ A+KIL++QK+ L + E + L+ P ++KL Sbjct: 40 TLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 99 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 S+++MVMEYV GGE+F ++ + GR E +R QI+ +Y H +++RDL Sbjct: 100 QVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDL 159 Query: 169 KPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGY-NKAVDWWAL 225 KPEN+L+D ++ DFG + + + T CG+P Y APE+I + Y VD W+ Sbjct: 160 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSS 219 Query: 226 GVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL 285 GV++Y + G PF D +++KI G P + + + LL+++LQVD KR Sbjct: 220 GVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKR---- 275 Query: 286 KNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEK-- 343 + DI+ H+WF +PK+ P D S ++E + EK Sbjct: 276 -ATIKDIREHEWFKQD--------------LPKYLFPEDPSYSSTMIDDEALKEVCEKFE 320 Query: 344 CGKE 347 C +E Sbjct: 321 CSEE 324 >4RED-A nrPDB Length = 351 Score = 171 bits (432), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 101/304 (33%), Positives = 160/304 (52%), Gaps = 24/304 (7%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 TLG G+FG+V + KH+ TG+ A+KIL++QK+ L + E + L+ P ++KL Sbjct: 21 TLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 80 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 S+++MVMEYV GGE+F ++ + GR E +R QI+ +Y H +++RDL Sbjct: 81 QVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDL 140 Query: 169 KPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGY-NKAVDWWAL 225 KPEN+L+D ++ DFG + + + T CG+P Y APE+I + Y VD W+ Sbjct: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSS 200 Query: 226 GVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL 285 GV++Y + G PF D +++KI G P + + + LL+++LQVD KR Sbjct: 201 GVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKR---- 256 Query: 286 KNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEK-- 343 + DI+ H+WF +PK+ P D S ++E + EK Sbjct: 257 -ASIKDIREHEWFKQD--------------LPKYLFPEDPSYSTTMIDDEALKEVCEKFE 301 Query: 344 CGKE 347 C +E Sbjct: 302 CSEE 305 >2JAM-A nrPDB Length = 304 Score = 169 bits (427), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 93/255 (36%), Positives = 146/255 (57%), Gaps = 11/255 (4%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 Q T F ++ LG+G+F V LVK + TG FA+K + K + +E NE + Sbjct: 3 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE---NEIAV 59 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ + +V LE ++ ++ Y+VM+ V GGE+F + G ++E A Q++ Sbjct: 60 LKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAV 119 Query: 156 EYLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVK-GRTWTLCGTPEYLAPEII 211 +YLH +++RDLKPENLL ++ I +TDFG +K + G T CGTP Y+APE++ Sbjct: 120 KYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVL 179 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL----K 267 K Y+KAVD W++GV+ Y + GYPPF+ + +++EKI G F S F D+ K Sbjct: 180 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 239 Query: 268 DLLRNLLQVDLTKRF 282 D + +LL+ D +R+ Sbjct: 240 DFICHLLEKDPNERY 254 >4YHJ-A nrPDB Length = 584 Score = 168 bits (425), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 100/288 (34%), Positives = 155/288 (53%), Gaps = 16/288 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + F + LG G FG V + + TG +A K L K+++ K K LNEKRIL+ V Sbjct: 185 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQS 244 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLH 159 F+V L Y+++ L +V+ + GG++ H+ +G F E A FYAA++ E L Sbjct: 245 RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQ 304 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFA------KRVKGRTWTLCGTPEYLAPEIILS 213 ++YRDLKPEN+L+D +G+I+++D G A +RV+GR GT Y+APE++ + Sbjct: 305 RERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRV----GTVGYMAPEVVNN 360 Query: 214 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPI----QIYEKIVSGKVRFPSHFSSDLKDL 269 + Y + DWW LG LIYEM G+ PF + ++ ++I + + FS D K + Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420 Query: 270 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 317 R LL + +KR G G +K H F ++ + +E PF P Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468 >4C0T-A nrPDB Length = 974 Score = 167 bits (423), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 90/269 (33%), Positives = 154/269 (57%), Gaps = 18/269 (6%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVK 106 K LG GS+ V+L K TG +A+K+LDK+ ++K K++++ EK L + N ++ Sbjct: 272 KELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVIS 331 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYR 166 L ++F+D +LY V++Y GE+ + ++R +E R + AQI+ +Y+H +I+R Sbjct: 332 LYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNGVIHR 391 Query: 167 DLKPENLLIDQQGYIQVTDFGFAK------------RVKGRTWTLCGTPEYLAPEIILSK 214 DLKPEN+L+D + IQ+TDFG A+ V R + GT EY++PE++ +K Sbjct: 392 DLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLENK 451 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLL 274 K D WA G +IY+M AG PPF A ++KI + F + F + ++DL++ +L Sbjct: 452 YCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTIIRDLIKKIL 511 Query: 275 QVDLTKRFGNLKNGVNDIKNHKWFATTDW 303 + ++R + +I+ H +F + D+ Sbjct: 512 VLQPSRRA-----TIPEIQKHYFFQSVDF 535 >5EZV-A nrPDB Length = 560 Score = 166 bits (420), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 92/275 (33%), Positives = 150/275 (54%), Gaps = 13/275 (4%) Query: 32 ENPAQNTAH-----LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI 86 ++PA+ H + + TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + Sbjct: 13 QDPAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV 72 Query: 87 EHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 146 E + L+ P ++KL ++ +MVMEYV GGE+F ++ + GR E AR Sbjct: 73 GKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARR 132 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPE 204 QI+ +Y H +++RDLKPEN+L+D ++ DFG + + + T CG+P Sbjct: 133 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 192 Query: 205 YLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS 263 Y APE+I + Y VD W+ GV++Y + G PF + +++KI G P + + Sbjct: 193 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 252 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + LL ++LQVD KR + DI+ H+WF Sbjct: 253 RSVATLLMHMLQVDPLKR-----ATIKDIREHEWF 282 >4CFF-A nrPDB Length = 571 Score = 166 bits (420), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 89/253 (35%), Positives = 142/253 (56%), Gaps = 8/253 (3%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + E + L+ P ++KL Sbjct: 40 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 99 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 ++ +MVMEYV GGE+F ++ + GR E AR QI+ +Y H +++RDL Sbjct: 100 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 159 Query: 169 KPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGY-NKAVDWWAL 225 KPEN+L+D ++ DFG + + + T CG+P Y APE+I + Y VD W+ Sbjct: 160 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 219 Query: 226 GVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL 285 GV++Y + G PF + +++KI G P + + + LL ++LQVD KR Sbjct: 220 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKR---- 275 Query: 286 KNGVNDIKNHKWF 298 + DI+ H+WF Sbjct: 276 -ATIKDIREHEWF 287 >2YCR-A nrPDB Length = 323 Score = 165 bits (417), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 102/280 (36%), Positives = 158/280 (56%), Gaps = 26/280 (9%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQK--VVKLKQIEHTLN---EKRIL 96 D++ KTLG+G+ G V L ++T A+KI+ K+K + ++ + LN E IL Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + +N P ++K++ +F D + Y+V+E + GGE+F + R E + Y Q++L + Sbjct: 70 KKLNHPCIIKIK-NFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 157 YLHSLDLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRTW---TLCGTPEYLAPEI 210 YLH +I+RDLKPEN+L+ Q I++TDFG +K + G T TLCGTP YLAPE+ Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTYLAPEV 187 Query: 211 ILS---KGYNKAVDWWALGVLIYEMAAGYPPFFADQP-IQIYEKIVSGKVRFP----SHF 262 ++S GYN+AVD W+LGV+++ +GYPPF + + + ++I SGK F + Sbjct: 188 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 247 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 S DL++ LL VD RF + H W D Sbjct: 248 SEKALDLVKKLLVVDPKARFTT-----EEALRHPWLQDED 282 >4D28-A nrPDB Length = 446 Score = 164 bits (416), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 90/277 (32%), Positives = 154/277 (55%), Gaps = 10/277 (3%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 + ++E +T+G G+F +V ++ +TG++ A+KI+ K ++K + ++ E I++ V Sbjct: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 P +V+L S +Y+V+E+V GGE+F + GR E +R Y Q+V + H Sbjct: 67 RHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIILSKGY 216 S + +RDLKPENLL+D G ++V+DFG + + L CGTP Y+APE++ +GY Sbjct: 127 SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGY 186 Query: 217 N-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 275 + A D W+ GV+++ + AGY PF +Y KI + + P FS+++K L+ +L Sbjct: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIHRILD 246 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 312 + R + IK WF +++ I R+ E Sbjct: 247 PNPKTRI-----QIQGIKKDPWF-RKNYVPIRAREEE 277 >5YKS-A nrPDB Length = 377 Score = 164 bits (414), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 94/260 (36%), Positives = 144/260 (55%), Gaps = 11/260 (4%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 KTLG G F V L +H TG A+K++DK K+ L H E R ++ V P +V+L Sbjct: 41 KTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLA-TGHLFQEVRCMKLVQHPNIVRL 99 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLHSLDLIYR 166 + LY+++E GG+MF ++ + +E A+ Y AQIV Y H L +++R Sbjct: 100 YEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHR 159 Query: 167 DLKPENLLI-DQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGYNK-AVDW 222 DLKPEN++ ++QG +++TDFGF+ + + + T CG+ Y APEI+L Y+ AVD Sbjct: 160 DLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDI 219 Query: 223 WALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRF 282 W+LGV+++ + G PPF + I+ K PSH S + KDL+ +LQ D +R Sbjct: 220 WSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRR- 278 Query: 283 GNLKNGVNDIKNHKWFATTD 302 + +I+NH W D Sbjct: 279 ----ASLEEIENHPWLQGVD 294 >5JZN-A nrPDB Length = 280 Score = 164 bits (414), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 94/262 (35%), Positives = 146/262 (55%), Gaps = 21/262 (8%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL-NEKRILQAVNFPFLVK 106 +T+G G+F V + T +A+KI+ K K + EH + NE IL+ V P +V Sbjct: 25 RTIGDGNFAVVKECVERSTAREYALKIIKKSKC---RGKEHMIQNEVSILRRVKHPNIVL 81 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYR 166 L + LY+VME V GG++F + +++E A + +YLHSL++++R Sbjct: 82 LIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHR 141 Query: 167 DLKPENLLI----DQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDW 222 D+KPENLL+ D +++ DFG A V G +T+CGTP Y+APEII GY VD Sbjct: 142 DIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDI 201 Query: 223 WALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFPSHF----SSDLKDLLRNLLQ 275 WA GV+ Y + G+PPF DQ + ++++I+ G+V FPS + S K+L+ +L Sbjct: 202 WAAGVITYILLCGFPPFRGSGDDQEV-LFDQILMGQVDFPSPYWDNVSDSAKELITMMLL 260 Query: 276 VDLTKRFGNLKNGVNDIKNHKW 297 VD+ +RF ++ + H W Sbjct: 261 VDVDQRFSAVQ-----VLEHPW 277 >4FG9-A nrPDB Length = 320 Score = 163 bits (413), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 92/268 (34%), Positives = 151/268 (56%), Gaps = 18/268 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL-NEKRILQAVN 100 D ++ LGTG+F V+L + K T A+K + K+ L+ E ++ NE +L + Sbjct: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEA---LEGKEGSMENEIAVLHKIK 74 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 P +V L+ ++ +LY++M+ V GGE+F + G ++E A Q++ +YLH Sbjct: 75 HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHD 134 Query: 161 LDLIYRDLKPENLL---IDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKG 215 L +++RDLKPENLL +D+ I ++DFG +K + T CGTP Y+APE++ K Sbjct: 135 LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKP 194 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL----KDLLR 271 Y+KAVD W++GV+ Y + GYPPF+ + +++E+I+ + F S + D+ KD +R Sbjct: 195 YSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIR 254 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 +L++ D KRF H W A Sbjct: 255 HLMEKDPEKRF-----TCEQALQHPWIA 277 >3NYO-A nrPDB Length = 576 Score = 163 bits (413), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 101/289 (34%), Positives = 156/289 (53%), Gaps = 18/289 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + F + + LG G FG V + + TG +A K L+K+++ K K LNEK+IL+ VN Sbjct: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--FYAAQIVLTFEYLH 159 F+V L Y+++ L +V+ + GG++ H+ +G+ P AR FYAA+I E LH Sbjct: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFA------KRVKGRTWTLCGTPEYLAPEIILS 213 ++YRDLKPEN+L+D G+I+++D G A + +KGR GT Y+APE++ + Sbjct: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV----GTVGYMAPEVVKN 359 Query: 214 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR-----FPSHFSSDLKD 268 + Y + DWWALG L+YEM AG P F + +I + V V+ + FS + Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSP-FQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 317 L LL D +R G ++K H F ++ + +E PF P Sbjct: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 >2YZA-A nrPDB Length = 276 Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 88/253 (34%), Positives = 141/253 (55%), Gaps = 8/253 (3%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + E + L+ P ++KL Sbjct: 18 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 77 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 ++ +MVMEYV GGE+F ++ + GR E AR QI+ +Y H +++RDL Sbjct: 78 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 137 Query: 169 KPENLLIDQQGYIQVTDFGFAKRVKGRTWTL--CGTPEYLAPEIILSKGY-NKAVDWWAL 225 KPEN+L+D ++ DFG + + + CG+P Y APE+I + Y VD W+ Sbjct: 138 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVDIWSC 197 Query: 226 GVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL 285 GV++Y + G PF + +++KI G P + + + LL ++LQVD KR Sbjct: 198 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKR---- 253 Query: 286 KNGVNDIKNHKWF 298 + DI+ H+WF Sbjct: 254 -ATIKDIREHEWF 265 >3I6U-A nrPDB Length = 419 Score = 162 bits (410), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 101/280 (36%), Positives = 158/280 (56%), Gaps = 26/280 (9%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQK--VVKLKQIEHTLN---EKRIL 96 D++ KTLG+G+ G V L ++T A++I+ K+K + ++ + LN E IL Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + +N P ++K++ +F D + Y+V+E + GGE+F + R E + Y Q++L + Sbjct: 195 KKLNHPCIIKIK-NFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 157 YLHSLDLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRTW---TLCGTPEYLAPEI 210 YLH +I+RDLKPEN+L+ Q I++TDFG +K + G T TLCGTP YLAPE+ Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTYLAPEV 312 Query: 211 ILS---KGYNKAVDWWALGVLIYEMAAGYPPFFADQP-IQIYEKIVSGKVRFP----SHF 262 ++S GYN+AVD W+LGV+++ +GYPPF + + + ++I SGK F + Sbjct: 313 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 372 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 S DL++ LL VD RF + H W D Sbjct: 373 SEKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDED 407 >2HAK-A nrPDB Length = 328 Score = 162 bits (409), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 87/231 (37%), Positives = 132/231 (57%), Gaps = 4/231 (1%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 H+ + KT+G G+F +V L +H TG A+KI+DK ++ ++ E RI++ + Sbjct: 13 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKIL 71 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 N P +VKL + LY+VMEY GGE+F +L GR E AR QIV +Y H Sbjct: 72 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 131 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 +++RDLK ENLL+D I++ DFGF+ V + T CG+P Y APE+ K Y+ Sbjct: 132 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYD 191 Query: 218 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 267 VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D + Sbjct: 192 GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCE 242 >6C9D-A nrPDB Length = 459 Score = 160 bits (406), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 86/231 (37%), Positives = 131/231 (56%), Gaps = 4/231 (1%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 H+ + KT+G G+F +V L +H TG A+KI+DK ++ ++ E RI++ + Sbjct: 19 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKIL 77 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 N P +VKL + LY+VMEY GGE+F +L GR E AR QIV +Y H Sbjct: 78 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 137 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 +++RDLK ENLL+D I++ DFGF+ V + CG+P Y APE+ K Y+ Sbjct: 138 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYD 197 Query: 218 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 267 VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D + Sbjct: 198 GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCE 248 >4YNZ-A nrPDB Length = 342 Score = 159 bits (403), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 89/271 (32%), Positives = 148/271 (54%), Gaps = 13/271 (4%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVK--LKQIEHTL 90 P + ++ + KTLG G G V L H T A+KI++++K+ + L ++E Sbjct: 1 GPLGSMQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVE--- 57 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 E IL+ + P ++KL +++ LY+V+E+V GGE+F +L + GR + AR + Q Sbjct: 58 REIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQ 117 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAP 208 I+ ++ HS + +RDLKPENLL+D++ I++ DFG A G + T CG+P Y P Sbjct: 118 IISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACP 177 Query: 209 EIILSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 267 E+I + Y+ + D W+ GV+++ + G PF D Q+ EK+ G P D + Sbjct: 178 EVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQ 237 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 LLR +++VD +R + I+ H W+ Sbjct: 238 SLLRGMIEVDAARRL-----TLEHIQKHIWY 263 >3HZT-A nrPDB Length = 467 Score = 157 bits (398), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 90/267 (33%), Positives = 145/267 (54%), Gaps = 15/267 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++R+K LG+G++G V+L K K TG A+KI+ K V L+E +L+ ++ Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL F+D N Y+VME GGE+F + +FSE A Q++ YLH Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 123 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGY 216 ++++RDLKPENLL++ + I++ DFG + V G+ GT Y+APE +L K Y Sbjct: 124 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPE-VLRKKY 182 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLRN 272 ++ D W+ GV++Y + GYPPF +I +++ GK F + S + K L++ Sbjct: 183 DEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKL 242 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFA 299 +L + +KR + NH W Sbjct: 243 MLTYEPSKRI-----SAEEALNHPWIV 264 >3DXN-A nrPDB Length = 287 Score = 157 bits (396), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 90/267 (33%), Positives = 145/267 (54%), Gaps = 15/267 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++R+K LG+G++G V+L K K TG A+KI+ K V L+E +L+ ++ Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL F+D N Y+VME GGE+F + +FSE A Q++ YLH Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 140 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGY 216 ++++RDLKPENLL++ + I++ DFG + V G+ GT Y+APE +L K Y Sbjct: 141 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPE-VLRKKY 199 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLRN 272 ++ D W+ GV++Y + GYPPF +I +++ GK F + S + K L++ Sbjct: 200 DEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKL 259 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFA 299 +L + +KR + NH W Sbjct: 260 MLTYEPSKRI-----SAEEALNHPWIV 281 >4UZD-A nrPDB Length = 287 Score = 156 bits (395), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 85/264 (32%), Positives = 146/264 (55%), Gaps = 8/264 (3%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-V 99 L+ FE + LG G FG V L + K++ A+K+L K ++ K +EH L + +Q+ + Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEK-AGVEHQLRREVEIQSHL 65 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 P +++L F D + +Y+++EY P G ++ L+++ +F E Y ++ Y H Sbjct: 66 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCH 125 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPEYLAPEIILSKGYNK 218 S +I+RD+KPENLL+ G +++ DFG++ R TLCGT +YL PE+I + +++ Sbjct: 126 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 185 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278 VD W+LGVL YE G PPF A+ + Y++I + FP + +DL+ LL+ + Sbjct: 186 KVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNP 245 Query: 279 TKRFGNLKNGVNDIKNHKWFATTD 302 ++R + ++ H W Sbjct: 246 SQR-----PMLREVLEHPWITANS 264 >3D2K-A nrPDB Length = 272 Score = 156 bits (395), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 84/260 (32%), Positives = 144/260 (55%), Gaps = 8/260 (3%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-V 99 L+ F+ + LG G FG V L + +++ A+K+L K ++ K +EH L + +Q+ + Sbjct: 11 LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEK-AGVEHQLRREVEIQSHL 69 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 P +++L F D + +Y+++EY P G ++ L+++ RF E Y ++ Y H Sbjct: 70 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCH 129 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPEYLAPEIILSKGYNK 218 S +I+RD+KPENLL+ G +++ DFG++ R TLCGT +YL PE+I + +++ Sbjct: 130 SKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 189 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278 VD W+LGVL YE G PPF A + Y +I + FP + +DL+ LL+ + Sbjct: 190 KVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNA 249 Query: 279 TKRFGNLKNGVNDIKNHKWF 298 ++R + ++ H W Sbjct: 250 SQRL-----TLAEVLEHPWI 264 >4CQG-A nrPDB Length = 331 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 89/262 (33%), Positives = 136/262 (51%), Gaps = 12/262 (4%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 L +E +T+GTG F +V L H TG A+KI+DK + + E L+++ Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALKSLR 65 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 + +L + + + ++MV+EY PGGE+F ++ R SE R QI+ Y+HS Sbjct: 66 HQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKGY 216 +RDLKPENLL D+ +++ DFG + KG CG+ Y APE+I K Y Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSY 185 Query: 217 -NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 275 D W++G+L+Y + G+ PF D + +Y+KI+ GK P S LL+ +LQ Sbjct: 186 LGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQ 245 Query: 276 VDLTKRFGNLKNGVNDIKNHKW 297 VD KR + ++ NH W Sbjct: 246 VDPKKRI-----SMRNLLNHPW 262 >4B8L-A nrPDB Length = 286 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 83/259 (32%), Positives = 143/259 (55%), Gaps = 8/259 (3%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-V 99 +D F+ + LG G FG V L + K+ A+K+L K ++ K + +EH L + +Q+ + Sbjct: 14 IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEK-EGVEHQLRREIEIQSHL 72 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 P ++++ F D +Y+++E+ P GE++ L++ GRF E + + ++ Y H Sbjct: 73 RHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCH 132 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-RTWTLCGTPEYLAPEIILSKGYNK 218 +I+RD+KPENLL+ +G +++ DFG++ R T+CGT +YL PE+I K +++ Sbjct: 133 ERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDE 192 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278 VD W GVL YE G PPF + + + +IV+ ++FP S KDL+ LL+ Sbjct: 193 KVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHP 252 Query: 279 TKRFGNLKNGVNDIKNHKW 297 +R + + H W Sbjct: 253 PQRL-----PLKGVMEHPW 266 >4D2V-A nrPDB Length = 356 Score = 150 bits (380), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 97/282 (34%), Positives = 144/282 (51%), Gaps = 15/282 (5%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKV-VKLKQIEHTLNEKRILQAV 99 L +E +T+GTG F +V L H TG A+KI+DK + L +I+ E L+ + Sbjct: 28 LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIK---TEIEALKNL 84 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 + +L + + + ++MV+EY PGGE+F ++ R SE R QIV Y+H Sbjct: 85 RHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVH 144 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG 215 S +RDLKPENLL D+ +++ DFG + KG CG Y APE+I K Sbjct: 145 SQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKS 204 Query: 216 Y-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLL 274 Y D W++G+L+Y + G+ PF D + KI+ GK P S LL+ +L Sbjct: 205 YLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQML 264 Query: 275 QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFI 316 QVD KR ++KN + NH W D+ + + + PFI Sbjct: 265 QVDPKKRI-SMKN----LLNHPWI-MQDYNYPVEWQSKNPFI 300 >4NIF-A nrPDB Length = 333 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 93/282 (32%), Positives = 145/282 (51%), Gaps = 25/282 (8%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 N D + +T+G GS+ HK T +A+K++DK K ++IE Sbjct: 1 GSNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE------I 54 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 +L+ P ++ L+ + D ++Y+V E + GGE+ + R FSE A F I T Sbjct: 55 LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKT 114 Query: 155 FEYLHSLDLIYRDLKPENLL-IDQQG---YIQVTDFGFAKRVK---GRTWTLCGTPEYLA 207 EYLHS +++RDLKP N+L +D+ G +++ DFGFAK+++ G T C T ++A Sbjct: 115 VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 174 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF---ADQPIQIYEKIVSGKVRFP----S 260 PE++ +GY++ D W+LG+L+Y M AGY PF +D P +I +I SGK + Sbjct: 175 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 234 Query: 261 HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 S KDL+ +L VD +R + H W D Sbjct: 235 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWVTQKD 271 >3LIJ-A nrPDB Length = 494 Score = 149 bits (376), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 90/259 (34%), Positives = 144/259 (55%), Gaps = 20/259 (7%) Query: 39 AHLDQ-FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 HL + ++R+K LG+G++G V+L + K T A+KI+ K V L E +L+ Sbjct: 33 GHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSN-SKLLEEVAVLK 91 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 ++ P ++KL F+D N Y+VME GGE+F + +F+E A Q++ Y Sbjct: 92 LLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTY 151 Query: 158 LHSLDLIYRDLKPENLLIDQQ---GYIQVTDFGFA------KRVKGRTWTLCGTPEYLAP 208 LH ++++RDLKPENLL++ + I++ DFG + K++K R GT Y+AP Sbjct: 152 LHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKER----LGTAYYIAP 207 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSS 264 E +L K Y++ D W++GV+++ + AGYPPF +I K+ GK F S + S Sbjct: 208 E-VLRKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSE 266 Query: 265 DLKDLLRNLLQVDLTKRFG 283 KDL++ +LQ D +R Sbjct: 267 GAKDLIKQMLQFDSQRRIS 285 >4JXF-A nrPDB Length = 266 Score = 148 bits (374), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 83/247 (33%), Positives = 132/247 (53%), Gaps = 4/247 (1%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++ F+ LG GSF V + TG A+K++DK+ + K ++ NE +I + Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLH 159 P +++L F+D++ +Y+V+E GEM +L+ R+ FSE AR + QI+ YLH Sbjct: 66 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 125 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGY 216 S +++RDL NLL+ + I++ DFG A ++K + +TLCGTP Y++PEI + Sbjct: 126 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 185 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 D W+LG + Y + G PPF D K+V PS S + KDL+ LL+ Sbjct: 186 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 245 Query: 277 DLTKRFG 283 + R Sbjct: 246 NPADRLS 252 >4JG6-A nrPDB Length = 355 Score = 148 bits (374), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 99/292 (33%), Positives = 149/292 (51%), Gaps = 26/292 (8%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D +E + +G GS+ HK T FA+KI+DK K ++IE +L+ Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIE------ILLRYGQH 88 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++ L+ + D +Y+V E + GGE+ + R FSE A I T EYLH+ Sbjct: 89 PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQ 148 Query: 162 DLIYRDLKPENLL-IDQQG---YIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSK 214 +++RDLKP N+L +D+ G I++ DFGFAK+++ G T C T ++APE++ + Sbjct: 149 GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQ 208 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFPSHF----SSDLK 267 GY+ A D W+LGVL+Y M GY PF D P +I +I SGK + S K Sbjct: 209 GYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAK 268 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ-RKVEAPFIPK 318 DL+ +L VD +R + H W D + YQ + +AP + K Sbjct: 269 DLVSKMLHVDPHQRLTAAL-----VLRHPWIVHWDQLPQYQLNRQDAPHLVK 315 >5XZW-A nrPDB Length = 471 Score = 147 bits (372), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 90/276 (32%), Positives = 142/276 (51%), Gaps = 30/276 (10%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + +G G+F V + TG FA+KI+ K+KV+ ++ E +LQ +N P +V+L Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIG--NMDGVTRELEVLQKLNHPRIVRL 259 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRD 167 + ++D + YMVME+V GG++ + G E R + QI+ +Y+HS+ + +RD Sbjct: 260 KGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRD 319 Query: 168 LKPENLLIDQQG--YIQVTDFGFAKRVKGRTW---TLCGTPEYLAPEIILSKG------- 215 LKP+N+LI+Q +++TDFG AK V+G T CGT Y+APE+I K Sbjct: 320 LKPDNILIEQDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDE 378 Query: 216 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSD 265 Y+ VD W++G L+Y + G+ PF Q+Y++I G S + Sbjct: 379 YEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEE 438 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 +D + +LLQVD R K NH W + Sbjct: 439 ARDFIDSLLQVDPNNRSTAAK-----ALNHPWIVDS 469 >3MN3-A nrPDB Length = 271 Score = 147 bits (372), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 86/263 (32%), Positives = 137/263 (52%), Gaps = 9/263 (3%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 AH+ ++ +KTLG GSFG+V L H TG A+KI++K+ + K E L+ Sbjct: 1 AHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRL 60 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + P ++KL K + MV+EY G E+F ++ + + SE AR + QI+ EY Sbjct: 61 LRHPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYC 119 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGY 216 H +++RDLKPENLL+D+ +++ DFG + + + T CG+P Y APE+I K Y Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 217 -NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 275 VD W+ GV++Y M PF + +++ I +G P S L++ +L Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLI 239 Query: 276 VDLTKRFGNLKNGVNDIKNHKWF 298 V+ R +++I WF Sbjct: 240 VNPLNRI-----SIHEIMQDDWF 257 >5IG1-A nrPDB Length = 344 Score = 147 bits (371), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 90/290 (31%), Positives = 153/290 (52%), Gaps = 15/290 (5%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +D ++ +G G+F V +K TG A+K++ K ++ +I E I ++ Sbjct: 16 VDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVI-ALKSLRSSEINKIKREIGICSSLQ 74 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 +V + +F+D S+ Y+V EYV GGE+F + ++E A QI+ ++ HS Sbjct: 75 HEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHS 134 Query: 161 LDLIYRDLKPENLLI---DQQGYIQVTDFGFAKRV-KGRTW-TLCGTPEYLAPEIILSKG 215 ++I+RDLKPENLL+ D +++TDFG A + +G T+ GTP YL+PE+I Sbjct: 135 KNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVP 194 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLR 271 Y+ AVD WA GV++Y + GYPPF+ + ++Y +I + + FPS ++ K+L++ Sbjct: 195 YDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIK 254 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG 321 +L+ + +R V ++ H W A D R+ + KF Sbjct: 255 AMLEPNPKRR-----PTVQELLQHPWIARRDVPGSVHRQATLEELKKFNA 299 >5FG8-A nrPDB Length = 285 Score = 146 bits (369), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 88/282 (31%), Positives = 148/282 (52%), Gaps = 16/282 (5%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK 93 PA T D ++ + LG G+F V K TG FA KI++ +K+ + + E Sbjct: 6 PAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTA-RDFQKLEREA 64 Query: 94 RILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 RI + ++ P +V+L S ++ + Y+V + V GGE+F + +SE A QI+ Sbjct: 65 RICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILE 124 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQG---YIQVTDFGFAKRVKG--RTW-TLCGTPEYLA 207 + + H +++RDLKPENLL+ + +++ DFG A V+G + W GTP YL+ Sbjct: 125 SVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLS 184 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFS 263 PE++ + Y K+VD WA GV++Y + GYPPF+ + ++Y +I +G +PS + Sbjct: 185 PEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVT 244 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIA 305 + K+L+ +L V+ KR + H W + +A Sbjct: 245 PEAKNLINQMLTVNPNKRI-----TAAEALKHPWICQRERVA 281 >4AF3-A nrPDB Length = 292 Score = 145 bits (367), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 84/259 (32%), Positives = 145/259 (55%), Gaps = 8/259 (3%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-V 99 +D FE + LG G FG V L + K++ A+K+L K ++ K + +EH L + +QA + Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEK-EGVEHQLRREIEIQAHL 80 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 + P +++L F D +Y+++EY P GE++ L++ F E ++ Y H Sbjct: 81 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 140 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-RTWTLCGTPEYLAPEIILSKGYNK 218 +I+RD+KPENLL+ +G +++ DFG++ R T+CGT +YL PE+I + +N+ Sbjct: 141 GKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNE 200 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278 VD W +GVL YE+ G PPF + + Y +IV ++FP+ + +DL+ LL+ + Sbjct: 201 KVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHNP 260 Query: 279 TKRFGNLKNGVNDIKNHKW 297 ++R + + H W Sbjct: 261 SERL-----PLAQVSAHPW 274 >2BDW-A nrPDB Length = 362 Score = 144 bits (363), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 84/250 (33%), Positives = 136/250 (54%), Gaps = 10/250 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D ++ + LG G+F V HK TG FA KI++ +K+ + + E RI + + Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKL-SARDFQKLEREARICRKLQH 87 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+L S ++ S Y+V + V GGE+F + +SE A QI+ + Y HS Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 147 Query: 162 DLIYRDLKPENLLIDQQG---YIQVTDFGFAKRVK-GRTW-TLCGTPEYLAPEIILSKGY 216 +++R+LKPENLL+ + +++ DFG A V W GTP YL+PE++ Y Sbjct: 148 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 207 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLRN 272 +K VD WA GV++Y + GYPPF+ + ++Y +I +G +PS + + K L+ + Sbjct: 208 SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDS 267 Query: 273 LLQVDLTKRF 282 +L V+ KR Sbjct: 268 MLTVNPKKRI 277 >3KK8-A nrPDB Length = 284 Score = 144 bits (362), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 85/255 (33%), Positives = 138/255 (54%), Gaps = 10/255 (3%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 +T D ++ + LG G+F V HK TG FA KI++ +K+ + + E RI Sbjct: 1 STKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKL-SARDFQKLEREARIC 59 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + + P +V+L S ++ S Y+V + V GGE+F + +SE A QI+ + Sbjct: 60 RKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIA 119 Query: 157 YLHSLDLIYRDLKPENLLIDQQG---YIQVTDFGFAKRVK-GRTW-TLCGTPEYLAPEII 211 Y HS +++R+LKPENLL+ + +++ DFG A V W GTP YL+PE++ Sbjct: 120 YCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL 179 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLK 267 Y+K VD WA GV++Y + GYPPF+ + ++Y +I +G +PS + + K Sbjct: 180 KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAK 239 Query: 268 DLLRNLLQVDLTKRF 282 L+ ++L V+ KR Sbjct: 240 SLIDSMLTVNPKKRI 254 >2Y7J-A nrPDB Length = 365 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 92/282 (32%), Positives = 149/282 (52%), Gaps = 21/282 (7%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILD-- 76 F + ED L W A +++ +G G V H+ TG+ FA+KI++ Sbjct: 74 FQSMGPEDELPDW---AAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVT 130 Query: 77 --KQKVVKLKQI-EHTLNEKRIL-QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSH 132 + +L+++ E T E IL Q P ++ L S++ +S +++V + + GE+F + Sbjct: 131 AERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDY 190 Query: 133 LRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV 192 L SE R ++ +LH+ ++++RDLKPEN+L+D I+++DFGF+ + Sbjct: 191 LTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL 250 Query: 193 KG--RTWTLCGTPEYLAPEIILSK------GYNKAVDWWALGVLIYEMAAGYPPFFADQP 244 + + LCGTP YLAPEI+ GY K VD WA GV+++ + AG PPF+ + Sbjct: 251 EPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQ 310 Query: 245 IQIYEKIVSGKVRFPS----HFSSDLKDLLRNLLQVDLTKRF 282 I + I+ G+ +F S SS +KDL+ LLQVD R Sbjct: 311 ILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARL 352 >4PDS-A nrPDB Length = 347 Score = 143 bits (360), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 88/273 (32%), Positives = 140/273 (51%), Gaps = 30/273 (10%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + +G G+F V + TG F++KI+ K+KV+ ++ E +LQ +N P +V+L Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIG--NMDGVTRELEVLQKLNHPRIVRL 94 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRD 167 + ++D + YMVME+V GG++ + G E R + QI+ +Y+HS+ + +RD Sbjct: 95 KGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRD 154 Query: 168 LKPENLLIDQQG--YIQVTDFGFAKRVKGRTW---TLCGTPEYLAPEIILSKG------- 215 LKP+N+LI+Q +++T FG AK V+G T CGT Y+APE+I K Sbjct: 155 LKPDNILIEQDDPVLVKITAFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDE 213 Query: 216 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSD 265 Y+ VD W++G L+Y + G+ PF Q+Y++I G S + Sbjct: 214 YEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEE 273 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 +D + +LLQVD R K NH W Sbjct: 274 ARDFIDSLLQVDPNNRSTAAK-----ALNHPWI 301 >6CMJ-A nrPDB Length = 321 Score = 142 bits (358), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 93/282 (32%), Positives = 142/282 (50%), Gaps = 24/282 (8%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLK--------QIE 87 Q+ LDQ+ +G GS+G V L ++ ++AMK+L K+K+++ IE Sbjct: 28 QDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIE 87 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKD--NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 145 E IL+ ++ P +VKL D +LYMV E V G + + + SE AR Sbjct: 88 QVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQAR 146 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGT 202 FY ++ EYLH +I+RD+KP NLL+ + G+I++ DFG + KG L GT Sbjct: 147 FYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGT 206 Query: 203 PEYLAPEIILSKG---YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP 259 P ++APE + KA+D WA+GV +Y G PF ++ + ++ KI S + FP Sbjct: 207 PAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFP 266 Query: 260 SH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 + DLKDL+ +L + R V +IK H W Sbjct: 267 DQPDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPWVT 303 >2VN9-A nrPDB Length = 301 Score = 142 bits (357), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 85/282 (30%), Positives = 143/282 (50%), Gaps = 16/282 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ + LG G+F V TG +A KI++ +K+ + + E RI + + Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL-SARDHQKLEREARICRLLKH 62 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+L S + Y+V + V GGE+F + +SE A QI+ + + H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKG--RTW-TLCGTPEYLAPEIILSKG 215 +++RDLKPENLL+ + +++ DFG A V+G + W GTP YL+PE++ Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLR 271 Y K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + KDL+ Sbjct: 183 YGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 242 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 +L ++ KR ++ H W +A + E Sbjct: 243 KMLTINPAKRI-----TASEALKHPWICQRSTVASMMHRQET 279 >4MVF-A nrPDB Length = 506 Score = 141 bits (356), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 84/259 (32%), Positives = 142/259 (54%), Gaps = 18/259 (6%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G++G V K T +A+K ++K +LK I E I++ ++ P +VKL Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIK---EEKKDRLKNINRFFQEIEIMKKLDHPNIVKLYE 121 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 169 ++++++ +Y++ME G E+F + G F+E +A QI YLHSL++++RDLK Sbjct: 122 TYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLK 181 Query: 170 PENLLI---DQQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEIILSKGYNKAVDWWA 224 PEN L ++ +++ DFG +K + T T GTP Y+AP+++ K Y+K D W+ Sbjct: 182 PENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGK-YDKKCDIWS 240 Query: 225 LGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRNLLQVDLTK 280 GV++Y + GYPPF+ D ++ +K+ G+ F + SSD K+L+ LL + + Sbjct: 241 SGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNPNE 300 Query: 281 RFGNLKNGVNDIKNHKWFA 299 R + + NH W Sbjct: 301 RC-----TIEEALNHPWIT 314 >5JN2-A nrPDB Length = 525 Score = 141 bits (356), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 89/272 (32%), Positives = 142/272 (52%), Gaps = 23/272 (8%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ + LG GSFG V+L K K TG A+K++ K++V + E L E ++L+ ++ Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL F+D Y+V E GGE+F + RFSE A Q++ Y+H Sbjct: 127 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 186 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGF------AKRVKGRTWTLCGTPEYLAPEIIL 212 +++RDLKPENLL++ + I++ DFG +K++K + GT Y+APE +L Sbjct: 187 KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDK----IGTAYYIAPE-VL 241 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKD 268 Y++ D W+ GV++Y + +G PPF I +K+ GK F S KD Sbjct: 242 HGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKD 301 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 L+R +L + R D +H+W T Sbjct: 302 LIRKMLTYVPSMRI-----SARDALDHEWIQT 328 >3MA6-A nrPDB Length = 298 Score = 141 bits (355), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 88/272 (32%), Positives = 143/272 (52%), Gaps = 23/272 (8%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ + LG GSFG V+L K K TG A+K++ K++V + E L E ++L+ ++ Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 91 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL F+D Y+V E GGE+F + RFSE A Q++ Y+H Sbjct: 92 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 151 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGF------AKRVKGRTWTLCGTPEYLAPEIIL 212 +++RDLKPENLL++ + I++ DFG +K++K + GT Y+APE +L Sbjct: 152 KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKI----GTAYYIAPE-VL 206 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKD 268 Y++ D W+ GV++Y + +G PPF I +K+ GK F S KD Sbjct: 207 HGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKD 266 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 L+R +L +++ D +H+W T Sbjct: 267 LIRKMLTY-----VPSMRISARDALDHEWIQT 293 >2V7O-A nrPDB Length = 336 Score = 141 bits (355), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 86/293 (29%), Positives = 147/293 (50%), Gaps = 16/293 (5%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 +++ A T D ++ + LG G+F V K +A KI++ +K+ + + Sbjct: 20 FQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKL-SARDHQKLE 78 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 E RI + + P +V+L S + Y+V + V GGE+F + +SE A Q Sbjct: 79 REARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQ 138 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKG--RTW-TLCGTPE 204 I+ + ++H D+++RDLKPENLL+ + +++ DFG A V+G + W GTP Sbjct: 139 ILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPG 198 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS---- 260 YL+PE++ Y K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS Sbjct: 199 YLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWD 258 Query: 261 HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 + + K+L+ +L ++ KR + H W +A + E Sbjct: 259 TVTPEAKNLINQMLTINPAKRI-----TADQALKHPWVCQRSTVASMMHRQET 306 >4I6B-A nrPDB Length = 308 Score = 140 bits (352), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 80/260 (30%), Positives = 131/260 (50%), Gaps = 8/260 (3%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ R KTLG G F + + +A KI+ +V K Q E E + + ++ Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHK 88 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 +V+ + F+D N+Y+++EY M L+ +EP R+Y QIV +YLH + Sbjct: 89 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 148 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNKA 219 +++RDLK N I++ ++V DFG A R ++ R T+CGTP YL+PE++ +G+ Sbjct: 149 ILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGAE 208 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLT 279 D WALG ++Y M G PPF + Y I + PS + K L+ ++L + Sbjct: 209 SDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPE 268 Query: 280 KRFGNLKNGVNDIKNHKWFA 299 R ++DI H +F Sbjct: 269 DR-----PSLDDIIRHDFFT 283 >1PHK-A nrPDB Length = 298 Score = 139 bits (351), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 90/272 (33%), Positives = 147/272 (54%), Gaps = 25/272 (9%) Query: 34 PAQNTAH--LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILD--------KQKVVKL 83 P ++ H + +E + LG G V HK T +A+KI+D ++V +L Sbjct: 7 PGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQEL 66 Query: 84 KQIEHTLNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP 142 + E TL E IL+ V+ P +++L+ +++ N+ ++V + + GE+F +L SE Sbjct: 67 R--EATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEK 124 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLC 200 R ++ LH L++++RDLKPEN+L+D I++TDFGF+ ++ + +C Sbjct: 125 ETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVC 184 Query: 201 GTPEYLAPEIILSK------GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254 GTP YLAPEII GY K VD W+ GV++Y + AG PPF+ + + + I+SG Sbjct: 185 GTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSG 244 Query: 255 KVRFPS----HFSSDLKDLLRNLLQVDLTKRF 282 +F S +S +KDL+ L V KR+ Sbjct: 245 NYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRY 276 >4RGJ-A nrPDB Length = 520 Score = 139 bits (350), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 93/320 (29%), Positives = 160/320 (50%), Gaps = 34/320 (10%) Query: 3 NAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQ----------NTAHLDQFERIKTLGT 52 N + K G+E+ +KE + ++ N ++ N +Q++ IK LG Sbjct: 11 NKKSLKGGNERHEMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGK 70 Query: 53 GSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFK 112 GSFG V+L + K TG+ +A+K++ K+ V + E L E +L+ ++ ++KL F+ Sbjct: 71 GSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFFE 130 Query: 113 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 172 DN+ Y+V + GGE+F + RF E A QI+ Y+H ++++RDLKPEN Sbjct: 131 DNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPEN 190 Query: 173 LLIDQQG----YIQVTDFG------FAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDW 222 +L++ + I++ DFG ++K++K + GT Y+AP+ +L Y++ D Sbjct: 191 ILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDK----IGTAYYIAPD-VLHGTYDEKCDI 245 Query: 223 WALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLRNLLQVDL 278 W+ GV++Y + +G PPF I +K+ +GK F S KDL++ +L Sbjct: 246 WSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTS 305 Query: 279 TKRFGNLKNGVNDIKNHKWF 298 R D H+W Sbjct: 306 AVRI-----SARDALEHEWI 320 >4YZB-A nrPDB Length = 491 Score = 139 bits (350), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 93/279 (33%), Positives = 144/279 (51%), Gaps = 23/279 (8%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 A D+++ + LG GSFG V+L K K TG +A+K++ K++V + E L E +L Sbjct: 25 TAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELL 84 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + ++ P ++KL F+D Y+V E GGE+F + RFSE A Q++ Sbjct: 85 KKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGIT 144 Query: 157 YLHSLDLIYRDLKPENLLIDQQ---GYIQVTDFGFA------KRVKGRTWTLCGTPEYLA 207 Y+H +++RDLKPENLL++ + I++ DFG + K++K + GT Y+A Sbjct: 145 YMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDK----IGTAYYIA 200 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFS 263 PE +L Y++ D W+ GV++Y + +G PPF I +K+ GK F S Sbjct: 201 PE-VLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVS 259 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 KDL+R +L T R D H+W TTD Sbjct: 260 EPAKDLIRKMLAYVPTMRI-----SARDALEHEWLKTTD 293 >4J52-A nrPDB Length = 293 Score = 139 bits (349), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 80/254 (31%), Positives = 133/254 (52%), Gaps = 8/254 (3%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G F + + +T FA KI+ K ++K Q E E I +++ +V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 169 F+DN +++V+E + +R +EP AR+Y QIVL +YLH +I+RDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 170 PENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG 226 NL +++ +++ DFG A +V+ R LCGTP Y+APE++ KG++ VD W++G Sbjct: 142 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIG 201 Query: 227 VLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLK 286 ++Y + G PPF + Y +I + P H + L++ +LQ D T R Sbjct: 202 CIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR----- 256 Query: 287 NGVNDIKNHKWFAT 300 +N++ N ++F + Sbjct: 257 PTINELLNDEFFTS 270 >2OU7-A nrPDB Length = 335 Score = 139 bits (349), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 80/254 (31%), Positives = 133/254 (52%), Gaps = 8/254 (3%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G F + + +T FA KI+ K ++K Q E E I +++ +V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 169 F+DN +++V+E + +R +EP AR+Y QIVL +YLH +I+RDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 170 PENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG 226 NL +++ +++ DFG A +V+ R LCGTP Y+APE++ KG++ VD W++G Sbjct: 169 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIG 228 Query: 227 VLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLK 286 ++Y + G PPF + Y +I + P H + L++ +LQ D T R Sbjct: 229 CIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR----- 283 Query: 287 NGVNDIKNHKWFAT 300 +N++ N ++F + Sbjct: 284 PTINELLNDEFFTS 297 >6FDY-U nrPDB Length = 276 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 89/277 (32%), Positives = 149/277 (53%), Gaps = 22/277 (7%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLV-KHKETGNHFAMKILDKQKVVKLKQIEHTLN 91 P LD F + LG+G++ V K+T A+K + K+ + K +E+ L Sbjct: 2 GPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNK-ASVENLLT 60 Query: 92 EKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEM--FSHLRRIGRFSEPHARFYAA 149 E IL+ + P +V+L+ D+ N+Y++ME+ GG++ F H RRI E AR + Sbjct: 61 EIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRI--LPEKVARVFMQ 118 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLID--QQGYIQVTDFGFAKRVKGRTW----TLCGTP 203 Q+ ++LH ++ + DLKP+N+L+ ++ ++++ DFGFA+ + W L G+P Sbjct: 119 QLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMS--PWDEKHVLRGSP 176 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV-RFPSH- 261 Y+APE++ + Y+ VD W++GV++YE G PPF + ++ EKI S +V P Sbjct: 177 LYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRP 236 Query: 262 -FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 S D +DLL+ LL+ D ++R D H W Sbjct: 237 LLSRDCRDLLQRLLERDPSRRI-----SFQDFFAHPW 268 >5U6Y-A nrPDB Length = 461 Score = 138 bits (348), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 82/280 (29%), Positives = 142/280 (50%), Gaps = 16/280 (5%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 ++ + LG G+F V G +A KI++ +K+ + + E RI + + P Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL-SARDHQKLEREARICRLLKHPN 60 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 +V+L S + + Y++ + V GGE+F + +SE A QI+ + H + + Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 164 IYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKG--RTW-TLCGTPEYLAPEIILSKGYN 217 ++RDLKPENLL+ + +++ DFG A V+G + W GTP YL+PE++ Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 180 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLRNL 273 K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + KDL+ + Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 240 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 L ++ +KR + H W + +A + E Sbjct: 241 LTINPSKRI-----TAAEALKHPWISHRSTVASCMHRQET 275 >4APC-A nrPDB Length = 350 Score = 138 bits (347), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 81/244 (33%), Positives = 137/244 (56%), Gaps = 13/244 (5%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++++ R++ +G GSFG+ +LVK E G + +K ++ ++ K+ E + E +L + Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSS-KEREESRREVAVLANMK 81 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL--RRIGRFSEPHARFYAAQIVLTFEYL 158 P +V+ SF++N +LY+VM+Y GG++F + ++ F E + QI L +++ Sbjct: 82 HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHV 141 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC----GTPEYLAPEIILSK 214 H +++RD+K +N+ + + G +Q+ DFG A RV T L GTP YL+PEI +K Sbjct: 142 HDRKILHRDIKSQNIFLTKDGTVQLGDFGIA-RVLNSTVELARACIGTPYYLSPEICENK 200 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS---HFSSDLKDLLR 271 YN D WALG ++YE+ F A + KI+SG FP H+S DL+ L+ Sbjct: 201 PYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGS--FPPVSLHYSYDLRSLVS 258 Query: 272 NLLQ 275 L + Sbjct: 259 QLFK 262 >3H4J-B nrPDB Length = 336 Score = 138 bits (347), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 82/267 (30%), Positives = 135/267 (50%), Gaps = 9/267 (3%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 A + H+ + +TLG GSFG+V L H +T A+K + +Q + K E Sbjct: 2 AISKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREIS 61 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 L+ + P ++KL +++ MV+EY GGE+F ++ R +E R + QI+ Sbjct: 62 YLKLLRHPHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICA 120 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIIL 212 EY H +++RDLKPENLL+D +++ DFG + + + T CG+P Y APE+I Sbjct: 121 IEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIN 180 Query: 213 SKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 K Y VD W+ G+++Y M G PF + +++K+ S P S + L+R Sbjct: 181 GKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIR 240 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWF 298 ++ D +R + +I+ WF Sbjct: 241 RMIVADPMQRI-----TIQEIRRDPWF 262 >5WAX-A nrPDB Length = 310 Score = 138 bits (347), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 144/268 (53%), Gaps = 20/268 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D++E ++ +G+G+FG L++++ G A+K +++ + + +N + ++ Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHR----SLRH 66 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +++ + ++L +VMEY GGE+F + GRFSE ARF+ Q++ Y HS+ Sbjct: 67 PNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 162 DLIYRDLKPENLLID--QQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L K Y+ Sbjct: 127 QVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 186 Query: 218 -KAVDWWALGVLIYEMAAGYPPF-FADQP---IQIYEKIVSGKVRFPS--HFSSDLKDLL 270 K D W+ GV +Y M G PF D+P + ++I+ + P H S + +DL+ Sbjct: 187 GKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQDLI 246 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + + R + +I+NH WF Sbjct: 247 SRIFVANPATRI-----TIPEIRNHPWF 269 >2VZ6-A nrPDB Length = 313 Score = 137 bits (346), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 82/279 (29%), Positives = 142/279 (50%), Gaps = 16/279 (5%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 ++ + LG G+F V G +A KI++ +K+ + + E RI + + P Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL-SARDHQKLEREARICRLLKHPN 82 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 +V+L S + + Y++ + V GGE+F + +SE A QI+ + H + + Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 164 IYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKG--RTW-TLCGTPEYLAPEIILSKGYN 217 ++RDLKPENLL+ + +++ DFG A V+G + W GTP YL+PE++ Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 202 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLRNL 273 K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + KDL+ + Sbjct: 203 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 262 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 312 L ++ +KR + H W + +A + E Sbjct: 263 LTINPSKRI-----TAAEALKHPWISHRSTVASCMHRQE 296 >3BHH-A nrPDB Length = 295 Score = 137 bits (346), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 84/291 (28%), Positives = 148/291 (50%), Gaps = 17/291 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ + +G G+F V TG+ +A KI++ +K+ + + E RI + + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKL-SARDHQKLEREARICRLLKH 62 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 +V+L S + Y+V + V GGE+F + +SE A QI+ + H + Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKG--RTW-TLCGTPEYLAPEIILSKG 215 +++RDLKPENLL+ + +++ DFG A V+G + W GTP YL+PE++ + Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLR 271 Y K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + K+L+ Sbjct: 183 YGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLIN 242 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIA-IYQRKVEAPFIPKFKG 321 +L ++ KR ++ H W +A + R+ + KF Sbjct: 243 QMLTINPAKRI-----TAHEALKHPWVCQRSTVASMMHRQETVECLKKFNA 288 >1NY3-A nrPDB Length = 400 Score = 137 bits (345), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 88/270 (32%), Positives = 142/270 (52%), Gaps = 31/270 (11%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + LG G G+V+ + +K T FA+K+L + + H +A P +V++ Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-------WRASQCPHIVRI 120 Query: 108 ----EYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSL 161 E + L +VME + GGE+FS ++ G F+E A I +YLHS+ Sbjct: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSKGY 216 ++ +RD+KPENLL + +++TDFGFAK T C TP Y+APE++ + Y Sbjct: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIY----EKIVSGKVRFP----SHFSSDLKD 268 +K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP S S ++K Sbjct: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 L+RNLL+ + T+R + + NH W Sbjct: 301 LIRNLLKTEPTQRM-----TITEFMNHPWI 325 >2OZA-A nrPDB Length = 356 Score = 137 bits (344), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 88/270 (32%), Positives = 142/270 (52%), Gaps = 31/270 (11%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + LG G G+V+ + +K T FA+K+L + + H +A P +V++ Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-------WRASQCPHIVRI 76 Query: 108 ----EYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSL 161 E + L +VME + GGE+FS ++ G F+E A I +YLHS+ Sbjct: 77 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 136 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSKGY 216 ++ +RD+KPENLL + +++TDFGFAK T C TP Y+APE++ + Y Sbjct: 137 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 196 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIY----EKIVSGKVRFP----SHFSSDLKD 268 +K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP S S ++K Sbjct: 197 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 256 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 L+RNLL+ + T+R + + NH W Sbjct: 257 LIRNLLKTEPTQRM-----TITEFMNHPWI 281 >4B6L-A nrPDB Length = 281 Score = 137 bits (344), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 79/265 (29%), Positives = 129/265 (48%), Gaps = 11/265 (4%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + LG G F R ETG+ +A+K++ + +V K Q E LNE + + + +V+ Sbjct: 15 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 74 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRD 167 + F+D N+Y+ +E + + EP R+Y QI+ +YLH +++RD Sbjct: 75 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 134 Query: 168 LKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAVDWWA 224 LK N I + ++V DFG A R++ R T+CGTP Y+APE++L +G+ D W+ Sbjct: 135 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWS 194 Query: 225 LGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGN 284 LG ++Y + G PPF + Y I P+ S + LL +L+ R Sbjct: 195 LGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDR--- 251 Query: 285 LKNGVNDIKNHKWFA---TTDWIAI 306 ++ I H +F T D + I Sbjct: 252 --PSIDQILRHDFFTKGYTPDRLPI 274 >3Q5I-A nrPDB Length = 504 Score = 135 bits (341), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 85/257 (33%), Positives = 138/257 (53%), Gaps = 24/257 (9%) Query: 46 RIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVK------LKQIE----HTLNEKRI 95 +++ LG+G++G V+L K K + A+K++ K + K K IE NE + Sbjct: 40 KVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISL 99 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L++++ P ++KL F+D Y+V E+ GGE+F + +F E A QI+ Sbjct: 100 LKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGI 159 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGY---IQVTDFG----FAKRVKGRTWTLCGTPEYLAP 208 YLH ++++RD+KPEN+L++ + I++ DFG F+K K R GT Y+AP Sbjct: 160 CYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRL--GTAYYIAP 217 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSS 264 E +L K YN+ D W+ GV++Y + GYPPF I +K+ GK F + S Sbjct: 218 E-VLKKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISD 276 Query: 265 DLKDLLRNLLQVDLTKR 281 + K+L++ +L D KR Sbjct: 277 EAKELIKLMLTYDYNKR 293 >3DB8-A nrPDB Length = 317 Score = 135 bits (340), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 82/281 (29%), Positives = 141/281 (50%), Gaps = 6/281 (2%) Query: 4 AAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH 63 +AA K S + S K LK+ + + + ++ R + LG G F + + Sbjct: 7 SAAIAKPSAKPSAH---VDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITD 63 Query: 64 KETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEY 123 +T FA K++ K ++K Q E E I ++++ P +V F+D+ +Y+V+E Sbjct: 64 MDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEI 123 Query: 124 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 183 + +R +EP AR++ Q + +YLH+ +I+RDLK NL ++ +++ Sbjct: 124 CRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKI 183 Query: 184 TDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240 DFG A +++ R LCGTP Y+APE++ KG++ VD W+LG ++Y + G PPF Sbjct: 184 GDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFE 243 Query: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + Y +I + P H + L+R +L D T R Sbjct: 244 TSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPTLR 284 >3UDB-A nrPDB Length = 317 Score = 135 bits (339), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 80/268 (29%), Positives = 142/268 (52%), Gaps = 20/268 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D++E +K +G G+FG L++ K+ A+K +++ + + +N + ++ Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHR----SLRH 74 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+ + ++L +VMEY GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 162 DLIYRDLKPENLLID--QQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L K Y+ Sbjct: 135 QVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYD 194 Query: 218 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 270 K D W+ GV +Y M G PF + + + K I++ + P H S + + L+ Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + D KR + +I+NH+WF Sbjct: 255 SRIFVADPAKRI-----SIPEIRNHEWF 277 >3KA0-A nrPDB Length = 320 Score = 135 bits (339), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 87/270 (32%), Positives = 141/270 (52%), Gaps = 31/270 (11%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + LG G G+V+ + +K T FA+K+L + + H +A P +V++ Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-------WRASQCPHIVRI 74 Query: 108 ----EYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSL 161 E + L +VME + GGE+FS ++ G F+E A I +YLHS+ Sbjct: 75 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 134 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRTWTL--CGTPEYLAPEIILSKGY 216 ++ +RD+KPENLL + +++TDFGFAK C TP Y+APE++ + Y Sbjct: 135 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPEKY 194 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIY----EKIVSGKVRFP----SHFSSDLKD 268 +K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP S S ++K Sbjct: 195 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 254 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 L+RNLL+ + T+R + + NH W Sbjct: 255 LIRNLLKTEPTQRM-----TITEFMNHPWI 279 >3SOA-A nrPDB Length = 444 Score = 135 bits (339), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 80/282 (28%), Positives = 143/282 (50%), Gaps = 16/282 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++++ + LG G+F V G +A I++ +K+ + + E RI + + Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKL-SARDHQKLEREARICRLLKH 69 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+L S + + Y++ + V GGE+F + +SE A QI+ + H + Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKG--RTW-TLCGTPEYLAPEIILSKG 215 +++R+LKPENLL+ + +++ DFG A V+G + W GTP YL+PE++ Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLR 271 Y K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + KDL+ Sbjct: 190 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 249 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 +L ++ +KR + H W + +A + E Sbjct: 250 KMLTINPSKRI-----TAAEALKHPWISHRSTVASCMHRQET 286 >3ZUT-A nrPDB Length = 362 Score = 134 bits (338), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 143/268 (53%), Gaps = 20/268 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D++E +K +G+G+FG L++ K++ A+K +++ + + +N + ++ Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR----SLRH 74 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+ + ++L +VMEY GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 Query: 162 DLIYRDLKPENLLIDQQGY--IQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 + +RDLK EN L+D +++ FG++K + + + GTP Y+APE++L K Y+ Sbjct: 135 QVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 Query: 218 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 270 K D W+ GV +Y M G PF + + + K I++ + P H S + + L+ Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + D KR + +I+NH+WF Sbjct: 255 SRIFVADPAKRI-----SIPEIRNHEWF 277 >3KN6-A nrPDB Length = 325 Score = 133 bits (334), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 86/261 (32%), Positives = 132/261 (50%), Gaps = 24/261 (9%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 H D + K LG GSF HK++ FA+KI+ K + +T E L+ Sbjct: 9 HYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISK------RMEANTQKEITALKLC 62 Query: 100 -NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 P +VKL F D + ++VME + GGE+F +++ FSE A + ++V ++ Sbjct: 63 EGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHM 122 Query: 159 HSLDLIYRDLKPENLLIDQQG---YIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIIL 212 H + +++RDLKPENLL + I++ DFGFA+ L C T Y APE++ Sbjct: 123 HDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLN 182 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPF-------FADQPIQIYEKIVSGKVRFPS----H 261 GY+++ D W+LGV++Y M +G PF ++I +KI G F + Sbjct: 183 QNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKN 242 Query: 262 FSSDLKDLLRNLLQVDLTKRF 282 S + KDL++ LL VD KR Sbjct: 243 VSQEAKDLIQGLLTVDPNKRL 263 >4LQP-A nrPDB Length = 508 Score = 132 bits (333), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 61/148 (41%), Positives = 98/148 (66%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + F +K +G G+FG V LV+ K+TG +AMK L K ++ K Q+ H E+ +L + Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P++V L YSF+D LY++ME++PGG++ + L R F+E RFY A+ +L E +H L Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFA 189 I+R +KP+N+LID +G+I+++DFG + Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 58/144 (40%), Positives = 86/144 (59%), Gaps = 8/144 (5%) Query: 197 WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS--G 254 ++ GTP+Y+APEI L +GY + DWW+LG ++YE G+PPF ++ P + Y KI++ Sbjct: 321 YSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQ 380 Query: 255 KVRFPS--HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 312 ++FP H S + +DL+R LL +R G G ++IK+H +F DW I R+VE Sbjct: 381 TLQFPDDIHISYEAEDLIRRLL-THADQRLGR-HGGADEIKSHPFFRGVDWNTI--RQVE 436 Query: 313 APFIPKFKGPGDTSNFDDYEEEEI 336 AP+IPK DT F E E + Sbjct: 437 APYIPKLSSITDTRFFPTDELENV 460 >3NCG-A nrPDB Length = 486 Score = 132 bits (332), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 78/242 (32%), Positives = 132/242 (54%), Gaps = 11/242 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 +++ + LG GSFG V+ K + T +A+K+++K K K L E +L+ ++ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKKLDH 80 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL +D+S+ Y+V E GGE+F + + RFSE A Q+ Y+H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRTWT--LCGTPEYLAPEIILSKGY 216 ++++RDLKPEN+L++ + I++ DFG + + T GT Y+APE +L Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPE-VLRGTY 199 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLRN 272 ++ D W+ GV++Y + +G PPF+ I +++ +GK F S D KDL+R Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 273 LL 274 +L Sbjct: 260 ML 261 >5YV8-A nrPDB Length = 298 Score = 132 bits (332), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 91/296 (30%), Positives = 141/296 (47%), Gaps = 39/296 (13%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLK------------ 84 + L+Q+ +G GS+G V L ++ ++AMK+L K+K+++ Sbjct: 8 DCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTR 67 Query: 85 -----------QIEHTLNEKRILQAVNFPFLVKLEYSFKD--NSNLYMVMEYVPGGEMFS 131 IE E IL+ ++ P +VKL D +LYMV E V G + Sbjct: 68 PAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM- 126 Query: 132 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191 + + SE ARFY ++ EYLH +I+RD+KP NLL+ + G+I++ DFG + Sbjct: 127 EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE 186 Query: 192 VKGRTWTL---CGTPEYLAPEIILSKG---YNKAVDWWALGVLIYEMAAGYPPFFADQPI 245 KG L GTP ++APE + KA+D WA+GV +Y G PF ++ + Sbjct: 187 FKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIM 246 Query: 246 QIYEKIVSGKVRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 ++ KI S + FP + DLKDL+ +L + R V +IK H W Sbjct: 247 CLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPWVT 297 >2W4O-A nrPDB Length = 349 Score = 132 bits (332), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 86/269 (31%), Positives = 141/269 (52%), Gaps = 21/269 (7%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK---QKVVKLKQIE 87 W + + A D FE LG G+ V K K T +A+K+L K +K+V+ Sbjct: 42 WIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVR----- 96 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY 147 E +L ++ P ++KL+ F+ + + +V+E V GGE+F + G +SE A Sbjct: 97 ---TEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADA 153 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQ---QGYIQVTDFGFAKRVKGRTW--TLCGT 202 QI+ YLH +++RDLKPENLL +++ DFG +K V+ + T+CGT Sbjct: 154 VKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGT 213 Query: 203 PEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ-IYEKIVSGKVRFPS- 260 P Y APEI+ Y VD W++G++ Y + G+ PF+ ++ Q ++ +I++ + F S Sbjct: 214 PGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISP 273 Query: 261 ---HFSSDLKDLLRNLLQVDLTKRFGNLK 286 S + KDL+R L+ +D KR + Sbjct: 274 WWDEVSLNAKDLVRKLIVLDPKKRLTTFQ 302 >3DFA-A nrPDB Length = 286 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 78/242 (32%), Positives = 132/242 (54%), Gaps = 11/242 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 +++ + LG GSFG V+ K + T +A+K+++K K K L E +L+ ++ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-KNKDTSTILREVELLKKLDH 80 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL +D+S+ Y+V E GGE+F + + RFSE A Q+ Y+H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRTWT--LCGTPEYLAPEIILSKGY 216 ++++RDLKPEN+L++ + I++ DFG + + T GT Y+APE +L Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPE-VLRGTY 199 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLRN 272 ++ D W+ GV++Y + +G PPF+ I +++ +GK F S D KDL+R Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 273 LL 274 +L Sbjct: 260 ML 261 >3FXW-A nrPDB Length = 336 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 88/269 (32%), Positives = 141/269 (52%), Gaps = 30/269 (11%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + LG G G+V+ H+ TG A+K+L + ++++H QA P +V + Sbjct: 35 QVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKAR-QEVDHHW------QASGGPHIVCI 87 Query: 108 ----EYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSL 161 E L ++ME + GGE+FS ++ G F+E A I ++LHS Sbjct: 88 LDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSH 147 Query: 162 DLIYRDLKPENLLI---DQQGYIQVTDFGFAKRV-KGRTWTLCGTPEYLAPEIILSKGYN 217 ++ +RD+KPENLL ++ +++TDFGFAK + T C TP Y+APE++ + Y+ Sbjct: 148 NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYD 207 Query: 218 KAVDWWALGVLIYEMAAGYPPFFAD--QPIQ--IYEKIVSGKVRFP----SHFSSDLKDL 269 K+ D W+LGV++Y + G+PPF+++ Q I + +I G+ FP S S D K L Sbjct: 208 KSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQL 267 Query: 270 LRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 +R LL+ D T+R + NH W Sbjct: 268 IRLLLKTDPTERL-----TITQFMNHPWI 291 >3UC3-A nrPDB Length = 361 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 137/268 (51%), Gaps = 20/268 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ +K +G+G+FG L++ K T A+K +++ + +N + ++ Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHR----SLRH 75 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+ + ++L ++MEY GGE++ + GRFSE ARF+ Q++ Y HS+ Sbjct: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 Query: 162 DLIYRDLKPENLLID--QQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L + Y+ Sbjct: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 Query: 218 -KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 270 K D W+ GV +Y M G PF + + Y K I+S K P S + L+ Sbjct: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + D R + +IK H WF Sbjct: 256 SRIFVADPATRI-----SIPEIKTHSWF 278 >3TAC-A nrPDB Length = 361 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 85/290 (29%), Positives = 144/290 (49%), Gaps = 27/290 (9%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI--EHTLNEKRILQAV 99 D +E + +G G F V ++ETG FA+KI+D K + E E I + Sbjct: 26 DVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHML 85 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEM-FSHLRRIGR---FSEPHARFYAAQIVLTF 155 P +V+L ++ + LYMV E++ G ++ F ++R +SE A Y QI+ Sbjct: 86 KHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEAL 145 Query: 156 EYLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVKGRTWTLCG----TPEYLAP 208 Y H ++I+RD+KP +L+ + +++ FG A ++ G + + G TP ++AP Sbjct: 146 RYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQL-GESGLVAGGRVGTPHFMAP 204 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSS 264 E++ + Y K VD W GV+++ + +G PF+ + +++E I+ GK + SH S Sbjct: 205 EVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKE-RLFEGIIKGKYKMNPRQWSHISE 263 Query: 265 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAP 314 KDL+R +L +D +R V + NH W D Y K+ P Sbjct: 264 SAKDLVRRMLMLDPAERI-----TVYEALNHPWLKERDR---YAYKIHLP 305 >2UV2-A nrPDB Length = 325 Score = 125 bits (313), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 79/267 (29%), Positives = 143/267 (53%), Gaps = 15/267 (5%) Query: 28 LKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIE 87 +K++E+ ++ D +E I LG G+FG+V ++KET A K++D + +++E Sbjct: 23 MKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSE---EELE 79 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-FSEPHARF 146 + E IL + + P +VKL +F +NL++++E+ GG + + + + R +E + Sbjct: 80 DYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQV 139 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA---KRVKGRTWTLCGTP 203 Q + YLH +I+RDLK N+L G I++ DFG + R R + GTP Sbjct: 140 VCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTP 199 Query: 204 EYLAPEIILS-----KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--- 255 ++APE+++ + Y+ D W+LG+ + EMA PP P+++ KI + Sbjct: 200 YWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPT 259 Query: 256 VRFPSHFSSDLKDLLRNLLQVDLTKRF 282 + PS +SS+ KD L+ L+ ++ R+ Sbjct: 260 LAQPSRWSSNFKDFLKKCLEKNVDARW 286 >3F3Z-A nrPDB Length = 277 Score = 124 bits (312), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 82/259 (31%), Positives = 131/259 (50%), Gaps = 18/259 (6%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 T+G GS+G V + K T A K + K V + ++ E I+++++ P +++L Sbjct: 16 TIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLDHPNIIRLY 72 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 +F+DN+++Y+VME GGE+F + F E A ++ Y H L++ +RDL Sbjct: 73 ETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAHRDL 132 Query: 169 KPENLLI---DQQGYIQVTDFGFAKRVK-GRTW-TLCGTPEYLAPEIILSKGYNKAVDWW 223 KPEN L +++ DFG A R K G+ T GTP Y++P+ +L Y D W Sbjct: 133 KPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQ-VLEGLYGPECDEW 191 Query: 224 ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLRNLLQVDLT 279 + GV++Y + GYPPF A ++ KI G FP + S + L+R LL Sbjct: 192 SAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRRLLTKSPK 251 Query: 280 KRFGNLKNGVNDIKNHKWF 298 +R +L+ H+WF Sbjct: 252 QRITSLQ-----ALEHEWF 265 >3Q53-A nrPDB Length = 306 Score = 124 bits (310), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 72/265 (27%), Positives = 135/265 (50%), Gaps = 10/265 (3%) Query: 23 AKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVK 82 + E+ L+K + ++ R + +G G+ G V TG A++ ++ Q+ K Sbjct: 2 SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPK 61 Query: 83 LKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP 142 + I +NE +++ P +V S+ L++VMEY+ GG + + E Sbjct: 62 KELI---INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEG 117 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTL 199 + + E+LHS +I+RD+K +N+L+ G +++TDFGF ++ + + T+ Sbjct: 118 QIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 177 Query: 200 CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KV 256 GTP ++APE++ K Y VD W+LG++ EM G PP+ + P++ I + ++ Sbjct: 178 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPEL 237 Query: 257 RFPSHFSSDLKDLLRNLLQVDLTKR 281 + P S+ +D L L++D+ KR Sbjct: 238 QNPEKLSAIFRDFLNRCLEMDVEKR 262 >4WNO-A nrPDB Length = 287 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 72/224 (32%), Positives = 122/224 (54%), Gaps = 19/224 (8%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGN-HFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 +F R +G G+F V +H+ + A+K ++K+ + K + + E +IL+ + Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL--LGKEIKILKELKH 76 Query: 102 PFLVKLEYSFKDNSN-LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 +V L Y F++ +N +Y+VMEY GG++ +L + SE R + QI LHS Sbjct: 77 ENIVAL-YDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHS 135 Query: 161 LDLIYRDLKPENLLIDQQG---------YIQVTDFGFAKRVKGRTW--TLCGTPEYLAPE 209 +I+RDLKP+N+L+ +++ DFGFA+ ++ TLCG+P Y+APE Sbjct: 136 KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPE 195 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI---YEK 250 +I+S+ Y+ D W++G ++Y+ G PF A P + YEK Sbjct: 196 VIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEK 239 >6FD3-A nrPDB Length = 300 Score = 122 bits (306), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 68/245 (27%), Positives = 128/245 (52%), Gaps = 10/245 (4%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ R + +G G+ G V TG A+K ++ Q+ K + I +NE +++ P Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI---INEILVMRENKNP 79 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 +V S+ L++VMEY+ GG + + E + + ++LHS Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQ 138 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGYNKA 219 +I+RD+K +N+L+ G +++TDFGF ++ + + T+ GTP ++APE++ K Y Sbjct: 139 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPK 198 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVRFPSHFSSDLKDLLRNLLQV 276 VD W+LG++ EM G PP+ + P++ I + +++ P S+ +D L L++ Sbjct: 199 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEM 258 Query: 277 DLTKR 281 D+ +R Sbjct: 259 DVDRR 263 >3COM-A nrPDB Length = 314 Score = 122 bits (306), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 78/254 (30%), Positives = 129/254 (50%), Gaps = 12/254 (4%) Query: 28 LKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIE 87 LKK + + + F+ ++ LG GS+G V HKETG A+K +V ++ Sbjct: 15 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIK-----QVPVESDLQ 69 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARF 146 + E I+Q + P +VK S+ N++L++VMEY G + +R R +E Sbjct: 70 EIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIAT 129 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTP 203 + EYLH + I+RD+K N+L++ +G+ ++ DFG A ++ + T+ GTP Sbjct: 130 ILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTP 189 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVRFPS 260 ++APE+I GYN D W+LG+ EMA G PP+ P++ I + R P Sbjct: 190 FWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPE 249 Query: 261 HFSSDLKDLLRNLL 274 +S + D ++ L Sbjct: 250 LWSDNFTDFVKQCL 263 >6HXF-B nrPDB Length = 302 Score = 122 bits (305), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 73/240 (30%), Positives = 134/240 (55%), Gaps = 15/240 (6%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 +E + LG G+FG+V K+KETG A K+++ + +++E + E IL + P+ Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSE---EELEDYIVEIEILATCDHPY 77 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLHSLD 162 +VKL ++ + L++++E+ PGG + + + + R +EP + Q++ +LHS Sbjct: 78 IVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKR 137 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGF-AKRVKG--RTWTLCGTPEYLAPEIILSKG---- 215 +I+RDLK N+L+ +G I++ DFG AK +K + + GTP ++APE+++ + Sbjct: 138 IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDT 197 Query: 216 -YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVRFPSHFSSDLKDLLR 271 Y+ D W+LG+ + EMA PP P+++ KI + PS +S + +D L+ Sbjct: 198 PYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 257 >6CCF-A nrPDB Length = 290 Score = 121 bits (304), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 91/293 (31%), Positives = 144/293 (49%), Gaps = 39/293 (13%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVV---------------- 81 + L+Q++ +G G++G V L ++ H+AMK+L K+K++ Sbjct: 1 SMQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQA 60 Query: 82 -------KLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNS--NLYMVMEYVPGGEMFSH 132 +L +E E IL+ ++ +VKL D + NLY+V + + G + Sbjct: 61 AQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVM-E 119 Query: 133 LRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV 192 + FSE AR Y ++L EYLH +++RD+KP NLL+ G++++ DFG + + Sbjct: 120 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 193 KGRTWTL---CGTPEYLAPEIILSKGYN---KAVDWWALGVLIYEMAAGYPPFFADQPIQ 246 +G L GTP ++APE I G + KA+D WA GV +Y G PF D + Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 239 Query: 247 IYEKIVSGKVRFP--SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 ++ KI + V FP S +LKDL+ +L + R GV DIK H W Sbjct: 240 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRI-----GVPDIKLHPW 287 >4KS7-A nrPDB Length = 292 Score = 120 bits (301), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 72/247 (29%), Positives = 134/247 (54%), Gaps = 13/247 (5%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 LD + +I G GS G V L + K +G A+K++D +K ++ E NE I++ Sbjct: 25 LDSYVKI---GEGSTGIVCLAREKHSGRQVAVKMMDLRKQ---QRRELLFNEVVIMRDYQ 78 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 +V++ S+ L+++ME++ GG + + ++ R +E ++ YLH+ Sbjct: 79 HFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAYLHA 137 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGYN 217 +I+RD+K +++L+ G ++++DFGF ++ + +L GTP ++APE+I Y Sbjct: 138 QGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYA 197 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVRFPSHFSSDLKDLLRNLL 274 VD W+LG+++ EM G PP+F+D P+Q +++ K++ S L+D L +L Sbjct: 198 TEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERML 257 Query: 275 QVDLTKR 281 D +R Sbjct: 258 VRDPQER 264 >6AO5-A nrPDB Length = 362 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 74/238 (31%), Positives = 123/238 (51%), Gaps = 12/238 (5%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F+ ++ LG GS+G V HKE+G A+K +V ++ + E I+Q + P+ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIK-----QVPVESDLQEIIKEISIMQQCDSPY 66 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLD 162 +VK S+ N++L++VMEY G + +R R E + EYLH + Sbjct: 67 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 126 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGYNKA 219 I+R++K N+L++ +G+ ++ DFG A ++ + T+ GTP ++APE+I GYN Sbjct: 127 KIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCV 186 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVRFPSHFSSDLKDLLRNLL 274 D W+LG+ EMA G PP+ P++ I + R P +S D D ++ L Sbjct: 187 ADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 244 >4LG4-A nrPDB Length = 299 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 74/238 (31%), Positives = 123/238 (51%), Gaps = 12/238 (5%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F+ ++ LG GS+G V HKE+G A+K +V ++ + E I+Q + P+ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIK-----QVPVESDLQEIIKEISIMQQCDSPY 67 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLD 162 +VK S+ N++L++VMEY G + +R R E + EYLH + Sbjct: 68 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 127 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGYNKA 219 I+R++K N+L++ +G+ ++ DFG A ++ + T+ GTP ++APE+I GYN Sbjct: 128 KIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCV 187 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVRFPSHFSSDLKDLLRNLL 274 D W+LG+ EMA G PP+ P++ I + R P +S D D ++ L Sbjct: 188 ADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 245 >2HW6-A nrPDB Length = 307 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 79/292 (27%), Positives = 136/292 (46%), Gaps = 58/292 (19%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQ----KVVKLKQIE---HTLNEKRILQAVNFP 102 LG G++ +V + G +A+KI++KQ + +++E K IL+ + F Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEF- 79 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 F+D++ Y+V E + GG + +H+++ F+E A + ++LH+ Sbjct: 80 --------FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKG 131 Query: 163 LIYRDLKPENLLI---DQQGYIQVTDFGFAKRVK----------GRTWTLCGTPEYLAPE 209 + +RDLKPEN+L ++ +++ DF +K T CG+ EY+APE Sbjct: 132 IAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPE 191 Query: 210 II-----LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI---------------QIYE 249 ++ + Y+K D W+LGV++Y M +GYPPF +++E Sbjct: 192 VVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFE 251 Query: 250 KIVSGKVRFP----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 I GK FP +H SS+ KDL+ LL D +R + + H W Sbjct: 252 SIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQ-----VLQHPW 298 >3M42-A nrPDB Length = 299 Score = 117 bits (293), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 81/268 (30%), Positives = 132/268 (49%), Gaps = 48/268 (17%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + LG G G+V+ + +K T FA+K+L + + H +A P +V++ Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-------WRASQCPHIVRI 76 Query: 108 ----EYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSL 161 E + L +VME + GGE+FS ++ G F+E A I +YLHS+ Sbjct: 77 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 136 Query: 162 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK 218 ++ +RD+KPENLL + +++TDFGFAK G + Y+K Sbjct: 137 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTG-------------------EKYDK 177 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIY----EKIVSGKVRFP----SHFSSDLKDLL 270 + D W+LGV++Y + GYPPF+++ + I +I G+ FP S S ++K L+ Sbjct: 178 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 237 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 RNLL+ + T+R + + NH W Sbjct: 238 RNLLKTEPTQRM-----TITEFMNHPWI 260 >3GUB-A nrPDB Length = 295 Score = 117 bits (293), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 79/274 (28%), Positives = 134/274 (48%), Gaps = 18/274 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ---IEHTLNEKRILQA 98 D ++ + LG+G F V + K TG +A K + K++ ++ E E IL+ Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + P ++ L +++ +++ ++ E V GGE+F L +E A + QI+ YL Sbjct: 71 IQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130 Query: 159 HSLDLIYRDLKPEN-LLIDQ---QGYIQVTDFGFAKRVK-GRTW-TLCGTPEYLAPEIIL 212 HSL + + DLKPEN +L+D+ + I++ DFG A ++ G + + GTPE++APEI+ Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVN 190 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL----KD 268 + D W++GV+ Y + +G PF D + + + F + S+ KD Sbjct: 191 YEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKD 250 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 +R LL D KR + D H W D Sbjct: 251 FIRRLLVKDPKKRM-----TIQDSLQHPWIKPKD 279 >6QAU-A nrPDB Length = 280 Score = 117 bits (292), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 68/215 (31%), Positives = 118/215 (54%), Gaps = 16/215 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGN-HFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++ + +G G+F V +H++ + A+K ++K+ + K + + E +IL+ + Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKELQH 69 Query: 102 PFLVKLEYSFKDNSN-LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 +V L Y ++ N +++VMEY GG++ +L+ G SE R + QI LHS Sbjct: 70 ENIVAL-YDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHS 128 Query: 161 LDLIYRDLKPENLLIDQQGY---------IQVTDFGFAKRVKGRTWT--LCGTPEYLAPE 209 +I+RDLKP+N+L+ I++ DFGFA+ + LCG+P Y+APE Sbjct: 129 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPE 188 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP 244 +I+S+ Y+ D W++G +IY+ G PPF A+ P Sbjct: 189 VIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSP 223 >2J90-A nrPDB Length = 304 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 74/257 (28%), Positives = 130/257 (50%), Gaps = 19/257 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKV------VKLKQIEHTLNEKRI 95 D +E + LG+G F V + K TG +A K + K+++ V ++IE +N I Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN---I 82 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ + P ++ L F++ +++ +++E V GGE+F L +E A + QI+ Sbjct: 83 LREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGV 142 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGY----IQVTDFGFAKRVKGRTW--TLCGTPEYLAPE 209 YLHS + + DLKPEN+++ + I++ DFG A +++ + GTPE++APE Sbjct: 143 HYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPE 202 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL--- 266 I+ + D W++GV+ Y + +G PF + + I + F + S+ Sbjct: 203 IVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSEL 262 Query: 267 -KDLLRNLLQVDLTKRF 282 KD +R LL D +R Sbjct: 263 AKDFIRRLLVKDPKRRM 279 >2XNP-A nrPDB Length = 279 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 74/250 (29%), Positives = 129/250 (51%), Gaps = 16/250 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + +E + T+GTGS+GR ++ K G K LD + + ++ + ++E +L+ + Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEK-QMLVSEVNLLRELKH 64 Query: 102 PFLVKLEYSFKD--NSNLYMVMEYVPGGEMFSHLRRIGR----FSEPHARFYAAQIVLTF 155 P +V+ D N+ LY+VMEY GG++ S + + + E Q+ L Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 156 EYLHSLD-----LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW---TLCGTPEYLA 207 + H +++RDLKP N+ +D + +++ DFG A+ + T T GTP Y++ Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMS 184 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV-RFPSHFSSDL 266 PE + YN+ D W+LG L+YE+ A PPF A ++ KI GK R P +S +L Sbjct: 185 PEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDEL 244 Query: 267 KDLLRNLLQV 276 +++ +L + Sbjct: 245 NEIITRMLNL 254 >3ZDU-A nrPDB Length = 325 Score = 114 bits (286), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 84/316 (26%), Positives = 146/316 (46%), Gaps = 44/316 (13%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++ +E + +G GS+G VM KHK TG A+KI ++ + +I + E + L+ + Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKI--AMREIKFLKQFH 59 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 LV L F+ +++V E++ + R Y QI+ +YLHS Sbjct: 60 HENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHS 119 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTW-TLCGTPEYLAPEIIL-SKGY 216 ++I+RD+KPEN+L+ Q G ++ DFGFA+ + G + T Y APE++L Y Sbjct: 120 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSY 179 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV------------------------ 252 K VD WALG +I EMA G P + + + KIV Sbjct: 180 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 239 Query: 253 --------SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI 304 + + ++P + L D++ LQ+D R + +D+ +H++F +I Sbjct: 240 LPQVQHPKNARKKYPK-LNGLLADIVHACLQIDPADRISS-----SDLLHHEYFTRDGFI 293 Query: 305 AIYQRKVEAPFIPKFK 320 + +++A + + K Sbjct: 294 EKFMPELKAKLLQEAK 309 >2YAB-A nrPDB Length = 361 Score = 114 bits (286), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 79/284 (27%), Positives = 135/284 (47%), Gaps = 18/284 (6%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ---IEHTLNEKRILQAVNFPFLVK 106 LG+G F V + K TG +A K + K++ ++ E E IL+ V P ++ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYR 166 L +++ +++ +++E V GGE+F L + SE A + QI+ YLH+ + + Sbjct: 80 LHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHF 139 Query: 167 DLKPENLLIDQQG----YIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGYNKAV 220 DLKPEN+++ + +I++ DFG A ++ + GTPE++APEI+ + Sbjct: 140 DLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEA 199 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF---SSDL-KDLLRNLLQV 276 D W++GV+ Y + +G PF D + I + F F +S+L KD +R LL Sbjct: 200 DMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVK 259 Query: 277 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFK 320 + KR + + H W D R+ + FK Sbjct: 260 ETRKRL-----TIQEALRHPWITPVDTQQAMVRRESVVNLENFK 298 >2F57-A nrPDB Length = 317 Score = 114 bits (284), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 75/255 (29%), Positives = 132/255 (51%), Gaps = 13/255 (5%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P +L F +I G GS G V + K TG A+K +D +K ++ E NE Sbjct: 39 SPGDPREYLANFIKI---GEGSTGIVCIATEKHTGKQVAVKKMDLRK---QQRRELLFNE 92 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 I++ + +V + S+ L++VME++ GG + + R +E ++ Sbjct: 93 VVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVL 151 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPE 209 YLH+ +I+RD+K +++L+ G I+++DFGF +V + +L GTP ++APE Sbjct: 152 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 211 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI---VSGKVRFPSHFSSDL 266 +I Y VD W+LG+++ EM G PP+F + P+Q +I + +V+ SS L Sbjct: 212 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 271 Query: 267 KDLLRNLLQVDLTKR 281 + L +L + ++R Sbjct: 272 RGFLDLMLVREPSQR 286 >1ZWS-A nrPDB Length = 288 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 78/269 (28%), Positives = 129/269 (47%), Gaps = 24/269 (8%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKV------VKLKQIEHTLNEKRILQAVNFPF 103 LG+G F V + K TG +A K + K++ V ++IE E IL+ V Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIE---REVSILRQVLHHN 76 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 ++ L +++ +++ +++E V GGE+F L + SE A + QI+ YLH+ + Sbjct: 77 VITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKI 136 Query: 164 IYRDLKPENLLIDQQG----YIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGYN 217 + DLKPEN+++ + +I++ DFG A ++ + GTPE++APEI+ + Sbjct: 137 AHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLG 196 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLRNL 273 D W++GV+ Y + +G PF D + I S F SH S KD +R L Sbjct: 197 LEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHTSELAKDFIRKL 256 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 L + KR + + H W D Sbjct: 257 LVKETRKRL-----TIQEALRHPWITPVD 280 >2BRG-A nrPDB Length = 297 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 69/211 (32%), Positives = 120/211 (56%), Gaps = 12/211 (5%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++ ++ ++TLG G++G V L ++ T A+KI+D ++ V E+ E I + +N Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP--ENIKKEICINKMLN 63 Query: 101 FPFLVKLEYSFKDNSNL-YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 +VK Y + N+ Y+ +EY GGE+F + EP A+ + Q++ YLH Sbjct: 64 HENVVKF-YGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--RVKGRTWTL---CGTPEYLAPEIILSK 214 + + +RD+KPENLL+D++ ++++DFG A R R L CGT Y+APE++ + Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 215 GYN-KAVDWWALGVLIYEMAAGYPPFFADQP 244 ++ + VD W+ G+++ M AG P+ DQP Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPW--DQP 211 >4XBR-A nrPDB Length = 366 Score = 112 bits (280), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 73/255 (28%), Positives = 131/255 (51%), Gaps = 13/255 (5%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P ++LD F +I G GS G V + + +G A+K +D +K ++ E NE Sbjct: 88 DPGDPRSYLDNFIKI---GEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNE 141 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 I++ +V++ S+ L++VME++ GG + + R +E ++ Sbjct: 142 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 200 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPE 209 LH+ +I+RD+K +++L+ G ++++DFGF +V R +L GTP ++APE Sbjct: 201 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 260 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI---VSGKVRFPSHFSSDL 266 +I Y VD W+LG+++ EM G PP+F + P++ + I + +++ S L Sbjct: 261 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 320 Query: 267 KDLLRNLLQVDLTKR 281 K L LL D +R Sbjct: 321 KGFLDRLLVRDPAQR 335 >4FIE-A nrPDB Length = 423 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 74/258 (28%), Positives = 133/258 (51%), Gaps = 19/258 (7%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P ++LD F +I G GS G V + + +G A+K +D + K ++ E NE Sbjct: 145 DPGDPRSYLDNFIKI---GEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNE 198 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGG---EMFSHLRRIGRFSEPHARFYAA 149 I++ +V++ S+ L++VME++ GG ++ +H R +E Sbjct: 199 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR----MNEEQIAAVCL 254 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYL 206 ++ LH+ +I+RD+K +++L+ G ++++DFGF +V R +L GTP ++ Sbjct: 255 AVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWM 314 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI---VSGKVRFPSHFS 263 APE+I Y VD W+LG+++ EM G PP+F + P++ + I + +++ S Sbjct: 315 APELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVS 374 Query: 264 SDLKDLLRNLLQVDLTKR 281 LK L LL D +R Sbjct: 375 PSLKGFLDRLLVRDPAQR 392 >2Q0N-A nrPDB Length = 301 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 74/258 (28%), Positives = 133/258 (51%), Gaps = 19/258 (7%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P ++LD F +I G GS G V + + +G A+K +D +K ++ E NE Sbjct: 23 DPGDPRSYLDNFIKI---GEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNE 76 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGG---EMFSHLRRIGRFSEPHARFYAA 149 I++ +V++ S+ L++VME++ GG ++ +H R +E Sbjct: 77 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTH----TRMNEEQIAAVCL 132 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYL 206 ++ LH+ +I+RD+K +++L+ G ++++DFGF +V R +L GTP ++ Sbjct: 133 AVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWM 192 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI---VSGKVRFPSHFS 263 APE+I Y VD W+LG+++ EM G PP+F + P++ + I + +++ S Sbjct: 193 APELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVS 252 Query: 264 SDLKDLLRNLLQVDLTKR 281 LK L LL D +R Sbjct: 253 PSLKGFLDRLLVRDPAQR 270 >4JDH-A nrPDB Length = 346 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 73/255 (28%), Positives = 131/255 (51%), Gaps = 13/255 (5%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P ++LD F +I G GS G V + + +G A+K +D +K ++ E NE Sbjct: 68 DPGDPRSYLDNFIKI---GEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNE 121 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 I++ +V++ S+ L++VME++ GG + + R +E ++ Sbjct: 122 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIAAVCLAVL 180 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPE 209 LH+ +I+RD+K +++L+ G ++++DFGF +V R +L GTP ++APE Sbjct: 181 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 240 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI---VSGKVRFPSHFSSDL 266 +I Y VD W+LG+++ EM G PP+F + P++ + I + +++ S L Sbjct: 241 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 300 Query: 267 KDLLRNLLQVDLTKR 281 K L LL D +R Sbjct: 301 KGFLDRLLVRDPAQR 315 >2X4F-A nrPDB Length = 373 Score = 110 bits (276), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 65/215 (30%), Positives = 111/215 (51%), Gaps = 8/215 (3%) Query: 46 RIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV 105 + + LG G FG+V + TG A KI+ K +K E NE ++ ++ L+ Sbjct: 93 KTEILGGGRFGQVHKCEETATGLKLAAKII---KTRGMKDKEEVKNEISVMNQLDHANLI 149 Query: 106 KLEYSFKDNSNLYMVMEYVPGGEMFSHL-RRIGRFSEPHARFYAAQIVLTFEYLHSLDLI 164 +L +F+ +++ +VMEYV GGE+F + +E + QI ++H + ++ Sbjct: 150 QLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYIL 209 Query: 165 YRDLKPENLLIDQQG--YIQVTDFGFAKRVKGRTWTLC--GTPEYLAPEIILSKGYNKAV 220 + DLKPEN+L + I++ DFG A+R K R GTPE+LAPE++ + Sbjct: 210 HLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPT 269 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255 D W++GV+ Y + +G PF D + I++ + Sbjct: 270 DMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACR 304 >2A27-A nrPDB Length = 321 Score = 110 bits (276), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 77/269 (28%), Positives = 131/269 (48%), Gaps = 24/269 (8%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKV------VKLKQIEHTLNEKRILQAVNFPF 103 LG+G F V + K TG +A K + K++ V ++IE E IL+ V Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIER---EVSILRQVLHHN 76 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 ++ L +++ +++ +++E V GGE+F L + SE A + QI+ YLH+ + Sbjct: 77 VITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKI 136 Query: 164 IYRDLKPENLLIDQQG----YIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGYN 217 + DLKPEN+++ + +I++ DFG A ++ + GTPE++APEI+ + Sbjct: 137 AHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLG 196 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF---SSDL-KDLLRNL 273 D W++GV+ Y + +G PF D + I + F F +S+L KD +R L Sbjct: 197 LEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKL 256 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 L + KR + + H W D Sbjct: 257 LVKETRKRL-----TIQEALRHPWITPVD 280 >3UTO-A nrPDB Length = 573 Score = 110 bits (275), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 88/318 (27%), Positives = 139/318 (43%), Gaps = 47/318 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL------DKQKVVKLKQIEHTLNEKR 94 LD ++ + LGTG+FG V V + TGN+FA K + DK+ V K E + Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRK---------EIQ 206 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVL 153 + + P LV L +F+D++ + M+ E++ GGE+F + + SE A Y Q+ Sbjct: 207 TMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCK 266 Query: 154 TFEYLHSLDLIYRDLKPENLL--IDQQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPE 209 ++H + ++ DLKPEN++ + +++ DFG + K GT E+ APE Sbjct: 267 GLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE 326 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSD 265 + K D W++GVL Y + +G PF + + + S S S D Sbjct: 327 VAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISED 386 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDT 325 KD +R LL D R + I+Q +E P++ PG Sbjct: 387 GKDFIRKLLLADPNTR----------------------MTIHQ-ALEHPWLTPGNAPGRD 423 Query: 326 SNFDDYEEEEIRVSINEK 343 S +IR SI K Sbjct: 424 SQIPSSRYTKIRDSIKTK 441 >1KOA-A nrPDB Length = 491 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 88/318 (27%), Positives = 139/318 (43%), Gaps = 47/318 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL------DKQKVVKLKQIEHTLNEKR 94 LD ++ + LGTG+FG V V + TGN+FA K + DK+ V K E + Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRK---------EIQ 100 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVL 153 + + P LV L +F+D++ + M+ E++ GGE+F + + SE A Y Q+ Sbjct: 101 TMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCK 160 Query: 154 TFEYLHSLDLIYRDLKPENLL--IDQQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPE 209 ++H + ++ DLKPEN++ + +++ DFG + K GT E+ APE Sbjct: 161 GLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE 220 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSD 265 + K D W++GVL Y + +G PF + + + S S S D Sbjct: 221 VAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISED 280 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDT 325 KD +R LL D R + I+Q +E P++ PG Sbjct: 281 GKDFIRKLLLADPNTR----------------------MTIHQ-ALEHPWLTPGNAPGRD 317 Query: 326 SNFDDYEEEEIRVSINEK 343 S +IR SI K Sbjct: 318 SQIPSSRYTKIRDSIKTK 335 >2WQN-A nrPDB Length = 310 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 78/267 (29%), Positives = 127/267 (47%), Gaps = 17/267 (6%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 +K P L F K +G G F V G A+K + ++ K Sbjct: 19 QKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARAD 78 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGE---MFSHLRRIGRF-SEPHA 144 + E +L+ +N P ++K SF +++ L +V+E G+ M H ++ R E Sbjct: 79 CIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTV 138 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW---TLCG 201 Y Q+ E++HS +++RD+KP N+ I G +++ D G + +T +L G Sbjct: 139 WKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVG 198 Query: 202 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR---- 257 TP Y++PE I GYN D W+LG L+YEMAA PF+ D+ + +Y + K+ Sbjct: 199 TPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDK-MNLYS--LCKKIEQCDY 255 Query: 258 --FPS-HFSSDLKDLLRNLLQVDLTKR 281 PS H+S +L+ L+ + D KR Sbjct: 256 PPLPSDHYSEELRQLVNMCINPDPEKR 282 >4BGQ-A nrPDB Length = 304 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 79/280 (28%), Positives = 138/280 (49%), Gaps = 41/280 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL-DKQKVVKLKQIEHTLNEKRILQAV 99 +++FE + +G G++G V+ +HKET A+K D ++ ++K E TL E ++L+ + Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVK--ETTLRELKMLRTL 68 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH-ARFYAAQIVLTFEYL 158 +V+L+ +F+ LY+V EYV M L + P + Y Q++ + Sbjct: 69 KQENIVELKEAFRRRGKLYLVFEYVEKN-MLELLEEMPNGVPPEKVKSYIYQLIKAIHWC 127 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTL---CGTPEYLAPEIILSK 214 H D+++RD+KPENLLI +++ DFGFA+ + +G T Y +PE++L Sbjct: 128 HKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA 187 Query: 215 GYNKAVDWWALGVLIYEMAAGYP-------------------PFFADQPIQIYEKIVSGK 255 Y K+VD W++G ++ E++ G P P ++Q Y Sbjct: 188 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 247 Query: 256 VRFPSH-------------FSSDLKDLLRNLLQVDLTKRF 282 +RFP+ +S L DL++NLL++D R+ Sbjct: 248 LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRY 287 >6CKI-A nrPDB Length = 316 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 80/290 (27%), Positives = 132/290 (45%), Gaps = 52/290 (17%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQ----KVVKLKQIEHTLNEKRILQAVNFPFL 104 LG G+ RV + T +A+KI++KQ + +++E + Q + Sbjct: 20 VLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVE------MLYQCQGHRNV 73 Query: 105 VKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLI 164 ++L F++ Y+V E + GG + SH+ + F+E A + ++LH+ + Sbjct: 74 LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIA 133 Query: 165 YRDLKPENLLID---QQGYIQVTDFGFAKRVK----------GRTWTLCGTPEYLAPEII 211 +RDLKPEN+L + Q +++ DFG +K T CG+ EY+APE++ Sbjct: 134 HRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVV 193 Query: 212 -----LSKGYNKAVDWWALGVLIYEMAAGYPPFF-------------ADQPIQ--IYEKI 251 + Y+K D W+LGV++Y + +GYPPF A Q ++E I Sbjct: 194 EAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESI 253 Query: 252 VSGKVRFP----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 GK FP +H S KDL+ LL D +R + + H W Sbjct: 254 QEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQ-----VLQHPW 298 >5TQX-A nrPDB Length = 655 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 80/248 (32%), Positives = 120/248 (48%), Gaps = 33/248 (13%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKIL-------DKQKVVKLKQIEHTLNEKRIL 96 +E + LGTG FG V L +H+E A+K ++++ QI LN ++ Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR---IGRFSEPHARFYAAQIVL 153 +A + P E + + + MEY GG++ L + E + I Sbjct: 70 KACDVPE----ELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGS 125 Query: 154 TFEYLHSLDLIYRDLKPENLLI-DQQGYI--QVTDFGFAKRV-KGRTWT-LCGTPEYLAP 208 YLH +I+RDLKPEN+++ D G I ++ D G+AK V +G T GT +YLAP Sbjct: 126 GIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAP 185 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD-QPIQIYEKI-------------VSG 254 E+ +K Y VD+W+ G +++E AGY PF QP +EKI +SG Sbjct: 186 ELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSG 245 Query: 255 KVRFPSHF 262 +VRF SH Sbjct: 246 EVRFSSHL 253 >1KOB-A nrPDB Length = 387 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 70/266 (26%), Positives = 128/266 (48%), Gaps = 17/266 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D ++ ++ LG+G+FG V K TG F K ++ + ++ NE I+ ++ Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK---NEISIMNQLHH 107 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 160 P L+ L +F+D + +++E++ GGE+F + + SE Y Q +++H Sbjct: 108 PKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHE 167 Query: 161 LDLIYRDLKPENLLIDQQ--GYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEIILSKGY 216 +++ D+KPEN++ + + +++ DFG A ++ T E+ APEI+ + Sbjct: 168 HSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREPV 227 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLRN 272 D WA+GVL Y + +G PF + ++ + + F S S + KD ++N Sbjct: 228 GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKN 287 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWF 298 LLQ + KR V+D H W Sbjct: 288 LLQKEPRKRL-----TVHDALEHPWL 308 >3QA8-A nrPDB Length = 676 Score = 107 bits (267), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 83/280 (29%), Positives = 131/280 (46%), Gaps = 36/280 (12%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P+ T +E + LGTG FG V+ H++TG A+K ++ + K E E Sbjct: 5 SPSLPTQTCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQE--LSPKNRERWCLE 62 Query: 93 KRILQAVNFPFLVKLE------YSFKDNSNLYMVMEYVPGGEMFSHLRR---IGRFSEPH 143 +I++ +N P +V N + MEY GG++ +L + E Sbjct: 63 IQIMKKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGP 122 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRV-KGRTWT- 198 R + I YLH +I+RDLKPEN+++ Q+ ++ D G+AK + +G T Sbjct: 123 IRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTE 182 Query: 199 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD-QPIQIYEKI------ 251 GT +YLAPE++ K Y VD+W+ G L +E G+ PF + QP+Q + K+ Sbjct: 183 FVGTLQYLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNE 242 Query: 252 -------VSGKVRF------PSHFSSDLKDLLRNLLQVDL 278 ++G V+F P+H S L L LQ L Sbjct: 243 HIVVYDDLTGAVKFSSVLPTPNHLSGILAGKLERWLQCML 282 >6E2O-A nrPDB Length = 295 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 83/253 (32%), Positives = 128/253 (50%), Gaps = 31/253 (12%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI-------EHTLNEKRILQA-VN 100 LG G++G V +A + L Q + +K+I L+E+ L + Sbjct: 29 VLGKGTYGIV-----------YAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLK 77 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRF--SEPHARFYAAQIVLTFEY 157 +V+ SF +N + + ME VPGG + + LR + G +E FY QI+ +Y Sbjct: 78 HKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKY 137 Query: 158 LHSLDLIYRDLKPENLLIDQ-QGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEII-- 211 LH +++RD+K +N+LI+ G ++++DFG +KR+ G T T GT +Y+APEII Sbjct: 138 LHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDK 197 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIVSGKV--RFPSHFSSDLKD 268 +GY KA D W+LG I EMA G PPF+ +P K+ KV P S++ K Sbjct: 198 GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA 257 Query: 269 LLRNLLQVDLTKR 281 + + D KR Sbjct: 258 FILKCFEPDPDKR 270 >3DLS-A nrPDB Length = 335 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 80/259 (30%), Positives = 131/259 (50%), Gaps = 18/259 (6%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH------TLNEKRIL 96 ++ + LG+G+FG V KE +K + K+KV++ IE TL E IL Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTL-EIAIL 83 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVME-YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 V ++K+ F++ +VME + G ++F+ + R R EP A + Q+V Sbjct: 84 SRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAV 143 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRT-WTLCGTPEYLAPEIILS 213 YL D+I+RD+K EN++I + I++ DFG A + +G+ +T CGT EY APE+++ Sbjct: 144 GYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMG 203 Query: 214 KGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 Y ++ W+LGV +Y + F + P E+ V + P S +L L+ Sbjct: 204 NPYRGPELEMWSLGVTLYTLV------FEENPFCELEETVEAAIHPPYLVSKELMSLVSG 257 Query: 273 LLQVDLTKRFGNLKNGVND 291 LLQ + +R L+ V D Sbjct: 258 LLQ-PVPERRTTLEKLVTD 275 >3IS5-A nrPDB Length = 285 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 73/264 (27%), Positives = 129/264 (48%), Gaps = 22/264 (8%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKV-VKLKQIEHTLNEKRILQAVNFPFLVK 106 + LG+G+FG V LV+ + +G +K ++K + V ++QIE E +L++++ P ++K Sbjct: 28 RKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIE---AEIEVLKSLDHPNIIK 84 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHL----RRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 + F+D N+Y+VME GGE+ + R SE + Q++ Y HS Sbjct: 85 IFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQH 144 Query: 163 LIYRDLKPENLLIDQ---QGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSKGYN 217 ++++DLKPEN+L I++ DFG A+ K + GT Y+APE + + Sbjct: 145 VVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPE-VFKRDVT 203 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH---FSSDLKDLLRNLL 274 D W+ GV++Y + G PF ++ +K + + + DLL+ +L Sbjct: 204 FKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAVDLLKQML 263 Query: 275 QVDLTKRFGNLKNGVNDIKNHKWF 298 D +R + +H+WF Sbjct: 264 TKDPERR-----PSAAQVLHHEWF 282 >4QMW-A nrPDB Length = 310 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 105/207 (50%), Gaps = 6/207 (2%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F +++ +G GSFG V T A+KI+D ++ + E +L + P+ Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 88 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 + K S+ ++ L+++MEY+ GG L G E +I+ +YLHS Sbjct: 89 VTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKK 147 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAV 220 I+RD+K N+L+ + G +++ DFG A ++ + T GTP ++APE+I Y+ Sbjct: 148 IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 207 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQI 247 D W+LG+ E+A G PP P+++ Sbjct: 208 DIWSLGITAIELARGEPPHSELHPMKV 234 >4X3F-A nrPDB Length = 337 Score = 105 bits (261), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 101/212 (47%), Gaps = 9/212 (4%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + + TG G+V G A+K+L + + IE E R +N P + + Sbjct: 18 RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 77 Query: 108 EYSFKDNSN-----LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 + N Y+VME V G + S L+R GR S HA Q + H+ Sbjct: 78 HDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAG 137 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKGYNK 218 L++RD+KP N+LI G +++TDFG AK V +T + GT +Y+APE L + Sbjct: 138 LVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASP 197 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250 A D ++LGV+ YE +G PF D + + K Sbjct: 198 ASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK 229 >4OW8-A nrPDB Length = 283 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 101/212 (47%), Gaps = 9/212 (4%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + + TG G+V G A+K+L + + IE E R +N P + + Sbjct: 17 RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 76 Query: 108 EYSFKDNSN-----LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 + N Y+VME V G + S L+R GR S HA Q + H+ Sbjct: 77 HDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAG 136 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKGYNK 218 L++RD+KP N+LI G +++TDFG AK V +T + GT +Y+APE L + Sbjct: 137 LVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASP 196 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250 A D ++LGV+ YE +G PF D + + K Sbjct: 197 ASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK 228 >4FZF-B nrPDB Length = 283 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 63/207 (30%), Positives = 105/207 (50%), Gaps = 6/207 (2%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F +++ +G GSFG V T A+KI+D ++ + E +L + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSY 67 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 + K S+ S L+++MEY+ GG L R G F E +I+ +YLHS Sbjct: 68 VTKYYGSYLKGSKLWIIMEYLGGGSALD-LLRAGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAV 220 I+RD+K N+L+ +QG +++ FG A ++ + T GTP ++APE+I Y+ Sbjct: 127 IHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 186 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQI 247 D W+LG+ E+A G PP P+++ Sbjct: 187 DIWSLGITAIELAKGEPPNSDMHPMRV 213 >6B2Q-A nrPDB Length = 317 Score = 104 bits (259), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 101/212 (47%), Gaps = 9/212 (4%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + + TG G+V G A+K+L + + IE E R +N P + + Sbjct: 38 RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 97 Query: 108 EYSFKDNSN-----LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 + N Y+VME V G + S L+R GR S HA Q + H+ Sbjct: 98 HDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAG 157 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKGYNK 218 L++RD+KP N+LI G +++TDFG AK V +T + GT +Y+APE L + Sbjct: 158 LVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASP 217 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250 A D ++LGV+ YE +G PF D + + K Sbjct: 218 ASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK 249 >2WTK-C nrPDB Length = 305 Score = 103 bits (258), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 83/268 (30%), Positives = 124/268 (46%), Gaps = 32/268 (11%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKIL----------DKQKVVKLKQIEHTLNEKRILQAV 99 LG GS+G+V V ET A+KIL + V K Q+ L K ++Q Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQ-- 70 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGG--EMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 LV + Y+ ++ +YMVMEY G EM + RF A Y Q++ EY Sbjct: 71 ----LVDVLYN-EEKQKMYMVMEYCVCGMQEMLDSVPE-KRFPVCQAHGYFCQLIDGLEY 124 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEII- 211 LHS ++++D+KP NLL+ G ++++ G A+ + T G+P + PEI Sbjct: 125 LHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIAN 184 Query: 212 -LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 270 L VD W+ GV +Y + G PF D +++E I G P L DLL Sbjct: 185 GLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLL 244 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + +L+ + KRF + I+ H WF Sbjct: 245 KGMLEYEPAKRF-----SIRQIRQHSWF 267 >3LM0-A nrPDB Length = 327 Score = 103 bits (258), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 74/242 (30%), Positives = 119/242 (49%), Gaps = 11/242 (4%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ-AVNFPFLVK 106 K LG G F V K TG +A K L K++ + + E L+E +L+ A + P ++ Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAE-ILHEIAVLELAKSCPRVIN 93 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFS-HLRRIGRF-SEPHARFYAAQIVLTFEYLHSLDLI 164 L +++ S + +++EY GGE+FS L + SE QI+ YLH +++ Sbjct: 94 LHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIV 153 Query: 165 YRDLKPENLLIDQ---QGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIILSKGYNK 218 + DLKP+N+L+ G I++ DFG ++++ G L GTPEYLAPEI+ Sbjct: 154 HLDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPITT 212 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278 A D W +G++ Y + PF + + Y I V + S + L + +Q L Sbjct: 213 ATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLL 272 Query: 279 TK 280 K Sbjct: 273 VK 274 >4KIK-B nrPDB Length = 677 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 81/280 (28%), Positives = 135/280 (48%), Gaps = 36/280 (12%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P+ T +E + LGTG FG V+ ++ETG A+K ++ + + E E Sbjct: 10 SPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQE--LSPRNRERWCLE 67 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNL------YMVMEYVPGGEMFSHLRR---IGRFSEPH 143 +I++ + P +V + NL + MEY GG++ +L + E Sbjct: 68 IQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGA 127 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ--QGYI-QVTDFGFAKRV-KGRTWT- 198 + I YLH +I+RDLKPEN+++ Q Q I ++ D G+AK + +G T Sbjct: 128 ILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTS 187 Query: 199 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD-QPIQIYEKI------ 251 GT +YLAPE++ + Y VD+W+ G L +E G+ PF + QP+Q + K+ Sbjct: 188 FVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEV 247 Query: 252 -------VSGKVRF------PSHFSSDLKDLLRNLLQVDL 278 ++G V+F P++ +S L + L LQ+ L Sbjct: 248 DIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLML 287 >2XIK-A nrPDB Length = 294 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 107/207 (51%), Gaps = 6/207 (2%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F ++ +G GSFG V T A+KI+D ++ + E +L + P+ Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 78 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 + + S+ ++ L+++MEY+ GG L+ G E + +I+ +YLHS Sbjct: 79 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERK 137 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAV 220 I+RD+K N+L+ +QG +++ DFG A ++ + T GTP ++APE+I Y+ Sbjct: 138 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 197 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQI 247 D W+LG+ E+A G PP P+++ Sbjct: 198 DIWSLGITAIELAKGEPPNSDLHPMRV 224 >6CQF-A nrPDB Length = 297 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 106/212 (50%), Gaps = 9/212 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D ++ ++ LG G++G V + K +G+ A+K++ + + ++ E IL+ Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ---KEILILKTCRH 72 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 +V S+ L++ ME+ G + + G SE + +++ YLHS Sbjct: 73 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQ 132 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPE---IILSKG 215 I+RD+K N+LI+ G +++ DFG + ++ R GTP ++APE + L G Sbjct: 133 KKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGG 192 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 YN+ D W+LG+ E+A PP F P+++ Sbjct: 193 YNELCDIWSLGITAIELAELQPPLFDVHPLRV 224 >4BBM-A nrPDB Length = 331 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 74/240 (30%), Positives = 120/240 (50%), Gaps = 34/240 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL---DKQKVVKLKQIEHTLNEKRILQ 97 ++++E + +G GS+G VM ++K+TG A+K D K+VK + + E ++L+ Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVK----KIAMREIKLLK 79 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYV-----------PGGEMFSHLRRIGRFSEPHARF 146 + LV L K Y+V E+V P G + +++ Sbjct: 80 QLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQK----------- 128 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTW-TLCGTP 203 Y QI+ + HS ++I+RD+KPEN+L+ Q G +++ DFGFA+ + G + T Sbjct: 129 YLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATR 188 Query: 204 EYLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPFFADQPI-QIYEKIVSGKVRFPSH 261 Y APE+++ Y KAVD WA+G L+ EM G P F D I Q+Y ++ P H Sbjct: 189 WYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRH 248 >5KKR-C nrPDB Length = 395 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 69/240 (28%), Positives = 119/240 (49%), Gaps = 11/240 (4%) Query: 3 NAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHL--DQFERIKTLGTGSFGRVML 60 N A +K E+ + E K E FL + Q L D FE+I LG G+ G V Sbjct: 31 NLEALQKKLEELELDEQQRKRLEAFLTQ----KQKVGELKDDDFEKISELGAGNGGVVFK 86 Query: 61 VKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMV 120 V HK +G A K++ + +K + E ++L N P++V +F + + + Sbjct: 87 VSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC 144 Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL-DLIYRDLKPENLLIDQQG 179 ME++ GG + L++ GR E + ++ YL +++RD+KP N+L++ +G Sbjct: 145 MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG 204 Query: 180 YIQVTDFGFAKR-VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAG-YP 237 I++ DFG + + + + GT Y++PE + Y+ D W++G+ + EMA G YP Sbjct: 205 EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP 264 >3EQC-A nrPDB Length = 360 Score = 100 bits (249), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 58/199 (29%), Positives = 104/199 (52%), Gaps = 5/199 (2%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D FE+I LG G+ G V V HK +G A K++ + +K + E ++L N Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 90 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P++V +F + + + ME++ GG + L++ GR E + ++ YL Sbjct: 91 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 150 Query: 162 -DLIYRDLKPENLLIDQQGYIQVTDFGFAKR-VKGRTWTLCGTPEYLAPEIILSKGYNKA 219 +++RD+KP N+L++ +G I++ DFG + + + + GT Y++PE + Y+ Sbjct: 151 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQ 210 Query: 220 VDWWALGVLIYEMAAG-YP 237 D W++G+ + EMA G YP Sbjct: 211 SDIWSMGLSLVEMAVGRYP 229 >3OHT-A nrPDB Length = 389 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 90/381 (23%), Positives = 171/381 (44%), Gaps = 50/381 (13%) Query: 2 GNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV 61 G+AAA S +E + + + WE P ++++ + +G+G++G V Sbjct: 21 GSAAAPFTMSHKERPTFYRQELNKTI---WEVP-------ERYQTLSPVGSGAYGSVCSS 70 Query: 62 KHKETGNHFAMKILDK--QKVVKLKQIEHTLNEKRILQAVNFPFLVKL------EYSFKD 113 ++G A+K L + Q ++ K+ T E R+L+ + ++ L S ++ Sbjct: 71 YDVKSGLKIAVKKLSRPFQSIIHAKR---TYRELRLLKHMKHENVIGLLDVFTPATSLEE 127 Query: 114 NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENL 173 +++Y+V + G +++ + + ++ H +F QI+ +Y+HS D+I+RDLKP NL Sbjct: 128 FNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL 185 Query: 174 LIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEM 232 +++ +++ DFG A+ T Y APEI+L+ YN VD W++G ++ E+ Sbjct: 186 AVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAEL 245 Query: 233 AAGYPPFFADQPIQIYEKIV--------SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGN 284 G F I ++I+ S R PSH + ++ + +L Q+ + F + Sbjct: 246 LTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSH---EARNYINSLPQMP-KRNFAD 301 Query: 285 LKNGVN----DIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE-------- 332 + G N D+ TD + P+ ++ P D + Y+ Sbjct: 302 VFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDPDDEPESEPYDQSFESRQL 361 Query: 333 --EEEIRVSINEKCGKEFSEF 351 EE R++ E C E F Sbjct: 362 EIEEWKRLTYEEVCSFETPPF 382 >4AN9-A nrPDB Length = 301 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 107/210 (50%), Gaps = 7/210 (3%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D FE+I LG G+ G V V HK +G A K++ + +K + E ++L N Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 66 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS- 160 P++V +F + + + ME++ GG + L++ GR E + ++ YL Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 126 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-LCGTPEYLAPEIILSKGYNKA 219 +++RD+KP N+L++ +G I++ DFG + ++ GT Y++PE + Y+ Sbjct: 127 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHYSVQ 186 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIYE 249 D W++G+ + EMA G P P+ I+E Sbjct: 187 SDIWSMGLSLVEMAVGRYP---RPPMAIFE 213 >4EQM-A nrPDB Length = 294 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 123/244 (50%), Gaps = 12/244 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMK---ILDKQKVVKLKQIEHTLNEKRILQA 98 ++++ + LG G V L + A+K I ++K LK+ E ++ L Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 N ++ ++ +++ Y+VMEY+ G + ++ G S A + QI+ ++ Sbjct: 71 QNIVSMIDVD---EEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHA 127 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT----LCGTPEYLAPEIILSK 214 H + +++RD+KP+N+LID +++ DFG AK + + T + GT +Y +PE + Sbjct: 128 HDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGE 187 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLL 274 ++ D +++G+++YEM G PPF + + I K + V P+ + KD+ ++L Sbjct: 188 ATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSV--PNVTTDVRKDIPQSLS 245 Query: 275 QVDL 278 V L Sbjct: 246 NVIL 249 >1S9I-A nrPDB Length = 354 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 103/199 (51%), Gaps = 5/199 (2%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D FERI LG G+ G V V+H+ +G A K++ + +K + E ++L N Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE--IKPAIRNQIIRELQVLHECNS 73 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P++V +F + + + ME++ GG + L+ R E + ++ YL Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK 133 Query: 162 -DLIYRDLKPENLLIDQQGYIQVTDFGFAKR-VKGRTWTLCGTPEYLAPEIILSKGYNKA 219 +++RD+KP N+L++ +G I++ DFG + + + + GT Y+APE + Y+ Sbjct: 134 HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQ 193 Query: 220 VDWWALGVLIYEMAAG-YP 237 D W++G+ + E+A G YP Sbjct: 194 SDIWSMGLSLVELAVGRYP 212 >5J5T-A nrPDB Length = 370 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 105/211 (49%), Gaps = 9/211 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + FE I+ +G+G++G V ++ TG A+K++ + ++ E +++ Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQ---QEIIMMKDCKH 60 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V S+ L++ ME+ GG + G SE + + + + YLHS Sbjct: 61 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 120 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSK---G 215 ++RD+K N+L+ G++++ DFG + ++ + GTP ++APE+ + G Sbjct: 121 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 246 YN+ D WA+G+ E+A PP F P++ Sbjct: 181 YNQLCDLWAVGITAIELAELQPPMFDLHPMR 211 >4EWQ-A nrPDB Length = 383 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 114/218 (52%), Gaps = 21/218 (9%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK--QKVVKLKQIEH 88 WE P ++++ + +G+G++G V +TG A+K L + Q ++ K+ Sbjct: 41 WEVP-------ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR--- 90 Query: 89 TLNEKRILQAVNFPFLVKL------EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP 142 T E R+L+ + ++ L S ++ +++Y+V + G +++ + + ++ Sbjct: 91 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM--GADLNNIVKCQKLTDD 148 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGT 202 H +F QI+ +Y+HS D+I+RDLKP NL +++ +++ DFG A+ T Sbjct: 149 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT 208 Query: 203 PEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF 239 Y APEI+L+ YN+ VD W++G ++ E+ G F Sbjct: 209 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLF 246 >5D7A-A nrPDB Length = 308 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 108/222 (48%), Gaps = 25/222 (11%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILD---------KQKVVKLKQIEHTLNEKR 94 FE ++ +G G++G+V +H +TG A+K++D KQ++ LK+ H N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRN--- 75 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI--GRFSEPHARFYAAQIV 152 A + +K D+ L++VME+ G + ++ E + +I+ Sbjct: 76 --IATYYGAFIKKNPPGMDDQ-LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 132 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAPE 209 +LH +I+RD+K +N+L+ + +++ DFG + R GR T GTP ++APE Sbjct: 133 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 192 Query: 210 IILS-----KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 246 +I Y+ D W+LG+ EMA G PP P++ Sbjct: 193 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 234 >6GU6-A nrPDB Length = 302 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 116/217 (53%), Gaps = 19/217 (8%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH-----TLNEKRI 95 ++ + +I+ +G G++G V +HK TG AMK ++L+ E + E + Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK------KIRLESEEEGVPSTAIREISL 59 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI--GRFSEPH-ARFYAAQIV 152 L+ + P +V L+ +S LY++ E++ ++ +L I G++ + + Y QI+ Sbjct: 60 LKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 118 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPE 209 + HS +++RDLKP+NLLID +G I++ DFG A+ + R +T T Y +PE Sbjct: 119 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 178 Query: 210 IIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 245 ++L S Y+ VD W++G + E+A P F D I Sbjct: 179 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 215 >4X7Q-B nrPDB Length = 312 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 69/244 (28%), Positives = 119/244 (48%), Gaps = 19/244 (7%) Query: 50 LGTGSFGRVMLVKHKETGN-HFAMKILDKQKVVKLKQIEHTLN---EKRILQAVN----F 101 LG G FG V H+ T A+K++ + +V+ + ++ E +L V Sbjct: 39 LGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGH 97 Query: 102 PFLVKLEYSFKDNSNLYMVMEY-VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 P +++L F+ +V+E +P ++F ++ G E +R + Q+V ++ HS Sbjct: 98 PGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHS 157 Query: 161 LDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTWT-LCGTPEYLAPEIILSKGYNK 218 +++RD+K EN+LID ++G ++ DFG + +T GT Y PE I Y+ Sbjct: 158 RGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHA 217 Query: 219 -AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 277 W+LG+L+Y+M G PF DQ +I+ ++ FP+H S D L+R L Sbjct: 218 LPATVWSLGILLYDMVCGDIPFERDQ------EILEAELHFPAHVSPDCCALIRRCLAPK 271 Query: 278 LTKR 281 + R Sbjct: 272 PSSR 275 >4AGU-A nrPDB Length = 311 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 62/203 (30%), Positives = 106/203 (52%), Gaps = 9/203 (4%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK-ILDKQKVVKLKQIEHTLNEKRILQAV 99 ++++E+I +G GS+G V ++++TG A+K L+ + +K+I L E R+L+ + Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKI--ALREIRMLKQL 59 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH-ARFYAAQIVLTFEYL 158 P LV L F+ L++V EY + L R R H + Q + + Sbjct: 60 KHPNLVNLLEVFRRKRRLHLVFEYC-DHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFC 118 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIILSKG 215 H + I+RD+KPEN+LI + I++ DFGFA+ + G + T Y +PE+++ Sbjct: 119 HKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 216 -YNKAVDWWALGVLIYEMAAGYP 237 Y VD WA+G + E+ +G P Sbjct: 179 QYGPPVDVWAIGCVFAELLSGVP 201 >1ZXE-A nrPDB Length = 303 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 135/277 (48%), Gaps = 44/277 (15%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 FE I LG G+FG+V+ ++ ++A+K + + +++ L+E +L ++N + Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTE----EKLSTILSEVMLLASLNHQY 63 Query: 104 LVK-----LE--------YSFKDNSNLYMVMEYVPGGEMFS--HLRRIGRFSEPHARFYA 148 +V+ LE + K S L++ MEY ++ H + + + + R + Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--------------G 194 QI+ Y+HS +I+R+LKP N+ ID+ +++ DFG AK V G Sbjct: 124 -QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 195 RTWTLC---GTPEYLAPEIILSKG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250 + L GT Y+A E++ G YN+ +D ++LG++ +EM YP + + I +K Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGMERVNILKK 240 Query: 251 IVSGKVRFPSHFSSDL----KDLLRNLLQVDLTKRFG 283 + S + FP F + K ++R L+ D KR G Sbjct: 241 LRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPG 277 >5ZTN-A nrPDB Length = 429 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 66/212 (31%), Positives = 108/212 (50%), Gaps = 29/212 (13%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL------DKQKVVKLKQIEH-------- 88 ++E +K +G GSFG+V+ + H A+K++ +Q +++ +EH Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 157 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNS-NLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY 147 T+N +L+ NF F + +F+ S NLY +++ + FS P R + Sbjct: 158 TMNVIHMLE--NFTFRNHICMTFELLSMNLYELIKK----------NKFQGFSLPLVRKF 205 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY--IQVTDFGFAKRVKGRTWTLCGTPEY 205 A I+ + LH +I+ DLKPEN+L+ QQG I+V DFG + R +T + Y Sbjct: 206 AHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFY 265 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYP 237 APE+IL Y +D W+LG ++ E+ GYP Sbjct: 266 RAPEVILGARYGMPIDMWSLGCILAELLTGYP 297 >2BPM-A nrPDB Length = 309 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 67/211 (31%), Positives = 112/211 (53%), Gaps = 8/211 (3%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT-LNEKRILQAV 99 ++ F++++ +G G++G V ++K TG A+K + + + + T + E +L+ + Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL 63 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGG-EMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 N P +VKL + LY+V E++ + F + P + Y Q++ + Sbjct: 64 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 123 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIIL-SK 214 HS +++RDLKP+NLLI+ +G I++ DFG A+ V RT+T T Y APEI+L K Sbjct: 124 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 183 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPI 245 Y+ AVD W+LG + EM F D I Sbjct: 184 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 214 >4IC8-A nrPDB Length = 442 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 112/218 (51%), Gaps = 38/218 (17%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ---- 97 D++E I+T+G G++G V + + TG A+K + V + + TL E +IL+ Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDV-VTNAKRTLRELKILKHFKH 113 Query: 98 --AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP----HARFYAAQI 151 + +++ + + ++Y+V++ M S L +I S+P H R++ Q+ Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDL-----MESDLHQIIHSSQPLTLEHVRYFLYQL 168 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE------- 204 + +Y+HS +I+RDLKP NLL+++ +++ DFG A+ LC +P Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR-------GLCTSPAEHQYFMT 221 Query: 205 -------YLAPEIILS-KGYNKAVDWWALGVLIYEMAA 234 Y APE++LS Y +A+D W++G + EM A Sbjct: 222 EYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLA 259 >5Z33-A nrPDB Length = 425 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 79/309 (25%), Positives = 139/309 (44%), Gaps = 55/309 (17%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETG---------NHFAMKILDKQKVVKLKQIEHTLNE 92 +++ K LG G++G V + +T N F+ KIL K+ + ++K ++H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 + N L ++ DN N + E + ++ + +R ++ H + + QI+ Sbjct: 91 R------NITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQIL 144 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-------GRTWTLCGTPEY 205 +Y+HS ++++RDLKP NLL++ +++ DFG A+ G T Y Sbjct: 145 CGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWY 204 Query: 206 LAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIY-------EKIVS 253 APEI+LS + Y KA+D W++G ++ E+ G P F + DQ QI E+ +S Sbjct: 205 RAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLS 264 Query: 254 -----------------GKVRFPSHF---SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIK 293 K FP+ F + D DLL +L D + R +++ + Sbjct: 265 RIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRI-SVEQALEHPY 323 Query: 294 NHKWFATTD 302 H W +D Sbjct: 324 LHIWHDASD 332 >5O2C-A nrPDB Length = 380 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 127/261 (48%), Gaps = 18/261 (6%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL-- 107 LG G+F V ET A L +K+ K +Q + E +L+ + P +V+ Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHPNIVRFYD 91 Query: 108 --EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD--L 163 E K + +V E + G + ++L+R R + QI+ ++LH+ + Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 151 Query: 164 IYRDLKPENLLID-QQGYIQVTDFGFAKRVKGR-TWTLCGTPEYLAPEIILSKGYNKAVD 221 I+RDLK +N+ I G +++ D G A ++ ++ GTPE++APE+ + Y+++VD Sbjct: 152 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEM-YEEHYDESVD 210 Query: 222 WWALGVLIYEMAAG-YPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDL 278 +A G+ + EMA YP QIY K+ SG F ++K+++ ++ + Sbjct: 211 VYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNK 270 Query: 279 TKRFGNLKNGVNDIKNHKWFA 299 ++R + D+ NH +FA Sbjct: 271 SERL-----SIRDLLNHAFFA 286 >4ZSG-A nrPDB Length = 347 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 112/218 (51%), Gaps = 38/218 (17%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ---- 97 D++E I+T+G G++G V + + TG A+K + V + + TL E +IL+ Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDV-VTNAKRTLRELKILKHFKH 65 Query: 98 --AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP----HARFYAAQI 151 + +++ + + ++Y+V++ M S L +I S+P H R++ Q+ Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDL-----MESDLHQIIHSSQPLTLEHVRYFLYQL 120 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE------- 204 + +Y+HS +I+RDLKP NLL+++ +++ DFG A+ LC +P Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR-------GLCTSPAEHQYFMT 173 Query: 205 -------YLAPEIILS-KGYNKAVDWWALGVLIYEMAA 234 Y APE++LS Y +A+D W++G + EM A Sbjct: 174 EYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLA 211 >3PPZ-A nrPDB Length = 309 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 111/211 (52%), Gaps = 13/211 (6%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 +G GSFG V + + G+ A+KIL +Q +++ L E I++ + P +V Sbjct: 45 IGAGSFGTVH--RAEWHGSDVAVKILMEQDF-HAERVNEFLREVAIMKRLRHPNIVLFMG 101 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIG---RFSEPHARFYAAQIVLTFEYLHSLD--LI 164 + NL +V EY+ G ++ L + G + E A + YLH+ + ++ Sbjct: 102 AVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIV 161 Query: 165 YRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW----TLCGTPEYLAPEIILSKGYNKAV 220 +RDLK NLL+D++ ++V DFG + R+K T+ + GTPE++APE++ + N+ Sbjct: 162 HRDLKSPNLLVDKKYTVKVCDFGLS-RLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKS 220 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKI 251 D ++ GV+++E+A P+ P Q+ + Sbjct: 221 DVYSFGVILWELATLQQPWGNLNPAQVVAAV 251 >4U41-A nrPDB Length = 332 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 107/222 (48%), Gaps = 25/222 (11%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILD---------KQKVVKLKQIEHTLNEKR 94 FE ++ +G G++G+V +H +TG A+K++D K ++ LK+ H N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRN--- 82 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI--GRFSEPHARFYAAQIV 152 A + +K D+ L++VME+ G + ++ E + + +I+ Sbjct: 83 --IATYYGAFIKKSPPGHDD-QLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 139 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA---KRVKGRTWTLCGTPEYLAPE 209 +LH +I+RD+K +N+L+ + +++ DFG + R GR T GTP ++APE Sbjct: 140 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 199 Query: 210 IILS-----KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 246 +I Y+ D W+ G+ EMA G PP P++ Sbjct: 200 VIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 241 >5O2B-A nrPDB Length = 285 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 127/261 (48%), Gaps = 18/261 (6%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL-- 107 LG G+F V ET A L +K+ K +Q + E +L+ + P +V+ Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHPNIVRFYD 82 Query: 108 --EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD--L 163 E K + +V E + G + ++L+R R + QI+ ++LH+ + Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 142 Query: 164 IYRDLKPENLLID-QQGYIQVTDFGFAKRVKGR-TWTLCGTPEYLAPEIILSKGYNKAVD 221 I+RDLK +N+ I G +++ D G A ++ ++ GTPE++APE+ + Y+++VD Sbjct: 143 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEM-YEEHYDESVD 201 Query: 222 WWALGVLIYEMAAG-YPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDL 278 +A G+ + EMA YP QIY K+ SG F ++K+++ ++ + Sbjct: 202 VYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNK 261 Query: 279 TKRFGNLKNGVNDIKNHKWFA 299 ++R + D+ NH +FA Sbjct: 262 SERL-----SIRDLLNHAFFA 277 >5X8I-B nrPDB Length = 346 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/226 (30%), Positives = 109/226 (48%), Gaps = 35/226 (15%) Query: 43 QFERIKTLGTGSFGRVM-LVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN- 100 ++E + TLG G+FG+V+ + HK G H A+KI+ + E +E ++L+ +N Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVD----RYCEAARSEIQVLEHLNT 69 Query: 101 ------FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIV 152 F + LE+ F+ + ++ +V E + G + ++ G F H R A QI Sbjct: 70 TDPNSTFRCVQMLEW-FEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQIC 127 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGY-------------------IQVTDFGFAKRVK 193 + +LHS L + DLKPEN+L Q Y I+V DFG A Sbjct: 128 KSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDD 187 Query: 194 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 TL T Y APE+IL+ G+++ D W++G ++ E G+ F Sbjct: 188 EHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVF 233 >2XYN-A nrPDB Length = 292 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 66/246 (26%), Positives = 116/246 (47%), Gaps = 19/246 (7%) Query: 41 LDQFERIKT-------LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK 93 +D++E +T LG G +G V + K+ A+K L + + ++E L E Sbjct: 24 MDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM----EVEEFLKEA 79 Query: 94 RILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQI 151 +++ + P LV+L Y+V EY+P G + +LR R + + A QI Sbjct: 80 AVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQI 139 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY----LA 207 EYL + I+RDL N L+ + ++V DFG ++ + G T+T ++ A Sbjct: 140 SSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA 199 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSD 265 PE + ++ D WA GVL++E+A G P+ Q+Y+ + G ++ P Sbjct: 200 PESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPK 259 Query: 266 LKDLLR 271 + +L+R Sbjct: 260 VYELMR 265 >1TKI-A nrPDB Length = 321 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 105/216 (48%), Gaps = 13/216 (6%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI--LQAVNFPFLVKL 107 LG G FG V + + K VK+K + L +K I L ++ L Sbjct: 13 LGRGEFGIVHRCVETSSKKTYMAKF------VKVKGTDQVLVKKEISILNIARHRNILHL 66 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYR 166 SF+ L M+ E++ G ++F + +E Y Q+ ++LHS ++ + Sbjct: 67 HESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHF 126 Query: 167 DLKPENLL--IDQQGYIQVTDFGFAKRVK-GRTWTLCGT-PEYLAPEIILSKGYNKAVDW 222 D++PEN++ + I++ +FG A+++K G + L T PEY APE+ + A D Sbjct: 127 DIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDM 186 Query: 223 WALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF 258 W+LG L+Y + +G PF A+ QI E I++ + F Sbjct: 187 WSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTF 222 >4TPT-A nrPDB Length = 303 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 102/209 (48%), Gaps = 28/209 (13%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT-LNEKRILQAVNFPFLVK 106 + LG G FG+ + V HK TG MK L + ++ + T L E +++++++ P ++K Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCD----EETQKTFLTEVKVMRSLDHPNVLK 61 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYR 166 + L ++ EY+ GG + LR + F +A I YLHS+ +I+R Sbjct: 62 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 167 DLKPENLLIDQQGYIQVTDFGFAKRV--------------KGRT---------WTLCGTP 203 DL N LI + V DFG ++ + K RT +T+ G P Sbjct: 122 DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNP 181 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEM 232 ++APE++ K Y++ VD ++ G+++ E+ Sbjct: 182 YWMAPEMLNGKSYDETVDIFSFGIVLCEI 210 >4PWN-A nrPDB Length = 274 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 132/263 (50%), Gaps = 23/263 (8%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL-- 107 +G GSF V ET A L +K+ K ++ + E +L+ + P +V+ Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSER-QRFKEEAEMLKGLQHPNIVRFYD 76 Query: 108 --EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD--L 163 E + K + +V E + G + ++L+R R + QI+ ++LH+ + Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPI 136 Query: 164 IYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGYNKAV 220 I+RDLK +N+ I G +++ D G A K ++ ++ GTPE++APE+ K Y+++V Sbjct: 137 IHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEEK-YDESV 195 Query: 221 DWWALGVLIYEMAAG-YPPFFADQPIQIYEKIVSGKVRFPSHFSS----DLKDLLRNLLQ 275 D +A G+ + EMA YP QIY ++ SG V+ P+ F ++K+++ ++ Sbjct: 196 DVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSG-VK-PASFDKVAIPEVKEIIEGCIR 253 Query: 276 VDLTKRFGNLKNGVNDIKNHKWF 298 + +R+ + D+ NH +F Sbjct: 254 QNKDERY-----SIKDLLNHAFF 271 >2GCD-A nrPDB Length = 309 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 95/202 (47%), Gaps = 8/202 (3%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F ++ +G GSFG V + A+K + ++ + + E R LQ + P Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLHSL 161 ++ + ++VMEY G S L + + E + YLHS Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSA--SDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH 134 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG---YNK 218 ++I+RD+K N+L+ + G +++ DFG A + + GTP ++APE+IL+ Y+ Sbjct: 135 NMIHRDVKAGNILLSEPGLVKLGDFGSAS-IMAPANSFVGTPYWMAPEVILAMDEGQYDG 193 Query: 219 AVDWWALGVLIYEMAAGYPPFF 240 VD W+LG+ E+A PP F Sbjct: 194 KVDVWSLGITCIELAERKPPLF 215 >1U5R-A nrPDB Length = 348 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 95/202 (47%), Gaps = 8/202 (3%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F ++ +G GSFG V + A+K + ++ + + E R LQ + P Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLHSL 161 ++ + ++VMEY G S L + + E + YLHS Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSA--SDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH 173 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG---YNK 218 ++I+RD+K N+L+ + G +++ DFG A + + GTP ++APE+IL+ Y+ Sbjct: 174 NMIHRDVKAGNILLSEPGLVKLGDFGSAS-IMAPANSFVGTPYWMAPEVILAMDEGQYDG 232 Query: 219 AVDWWALGVLIYEMAAGYPPFF 240 VD W+LG+ E+A PP F Sbjct: 233 KVDVWSLGITCIELAERKPPLF 254 >4MYG-A nrPDB Length = 372 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 81/313 (25%), Positives = 142/313 (45%), Gaps = 26/313 (8%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDK--QKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 +G+G++G V K +G A+K L + Q + K+ L + +Q N L+ + Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 108 ---EYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSLD 162 S ++ + Y+VM + M + L++I FSE ++ Q++ +Y+HS Sbjct: 111 FTPASSLRNFYDFYLVMPF-----MQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAG 165 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KGYNKAVD 221 +++RDLKP NL +++ +++ DFG A+ T Y APE+ILS YN+ VD Sbjct: 166 VVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVD 225 Query: 222 WWALGVLIYEMAAGYPPF----FADQPIQIYEKIVSGKVRFPSHFSSD-LKDLLRNLLQV 276 W++G ++ EM G F + DQ QI + F + K +++L Q Sbjct: 226 IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 285 Query: 277 ---DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN----FD 329 D T+ F D+ D + + PF F+ P + + FD Sbjct: 286 PRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFD 345 Query: 330 DYEEEEIRVSINE 342 D E E +++++E Sbjct: 346 DSLEHE-KLTVDE 357 >4RC3-A nrPDB Length = 289 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 71/265 (26%), Positives = 129/265 (48%), Gaps = 20/265 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN---EKRILQAV 99 Q++ LG+G FG V A+K ++K ++ ++ + E +L+ V Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 100 N--FPFLVKLEYSFKDNSNLYMVMEYV-PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + F +++L F+ + +++E P ++F + G E AR + Q++ Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 132 Query: 157 YLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTWT-LCGTPEYLAPEIILSK 214 + H+ +++RD+K EN+LID +G +++ DFG +K +T GT Y PE I Sbjct: 133 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 192 Query: 215 GYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 Y+ ++ W+LG+L+Y+M G PF D E+I+ G+V F SS+ + L+R Sbjct: 193 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 246 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWF 298 L + + R +I+NH W Sbjct: 247 LALRPSDR-----PTFEEIQNHPWM 266 >3GC9-A nrPDB Length = 370 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/338 (22%), Positives = 148/338 (43%), Gaps = 32/338 (9%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK--QKVVKLKQIEH 88 WE P + + ++ +G+G++G V A+K L + Q ++ ++ Sbjct: 24 WEVP-------QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR--- 73 Query: 89 TLNEKRILQAVNFPFLVKL------EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP 142 T E R+L+ + ++ L S +D S +Y+V + G +++ + S+ Sbjct: 74 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM--GADLNNIVKSQALSDE 131 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGT 202 H +F Q++ +Y+HS +I+RDLKP N+ +++ +++ DFG A++ T Sbjct: 132 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYVAT 191 Query: 203 PEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIYEKIVSGKVR 257 Y APEI+L+ YN+ VD W++G ++ E+ G F + DQ +I E + + Sbjct: 192 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 251 Query: 258 FPSHFSSDLKDL----LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 + SS+ L + Q DL+ F D+ +D + Sbjct: 252 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAH 311 Query: 314 PFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351 + ++ P D + Y+E V E+ +E+ E Sbjct: 312 AYFSQYHDPEDEPEAEPYDES---VEAKERTLEEWKEL 346 >3BGP-A nrPDB Length = 333 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 71/265 (26%), Positives = 129/265 (48%), Gaps = 20/265 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN---EKRILQAV 99 Q++ LG+G FG V A+K ++K ++ ++ + E +L+ V Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 100 N--FPFLVKLEYSFKDNSNLYMVMEYV-PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + F +++L F+ + +++E P ++F + G E AR + Q++ Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 176 Query: 157 YLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTWT-LCGTPEYLAPEIILSK 214 + H+ +++RD+K EN+LID +G +++ DFG +K +T GT Y PE I Sbjct: 177 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 236 Query: 215 GYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 Y+ ++ W+LG+L+Y+M G PF D E+I+ G+V F SS+ + L+R Sbjct: 237 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 290 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWF 298 L + + R +I+NH W Sbjct: 291 LALRPSDR-----PTFEEIQNHPWM 310 >3ORP-A nrPDB Length = 311 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 96/220 (43%), Gaps = 11/220 (5%) Query: 39 AHL-DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 +HL D++E + LG G V L + A+K+L E + Sbjct: 8 SHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAA 67 Query: 98 AVNFPFLVKL----EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 A+N P +V + E Y+VMEYV G + + G + A A Sbjct: 68 ALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQ 127 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG------RTWTLCGTPEYLA 207 + H +I+RD+KP N++I ++V DFG A+ + +T + GT +YL+ Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLS 187 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 PE + D ++LG ++YE+ G PPF D P+ + Sbjct: 188 PEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSV 227 >5AWM-A nrPDB Length = 394 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 68/246 (27%), Positives = 119/246 (48%), Gaps = 22/246 (8%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK--QKVVKLKQIEHTLNEKRILQAVN 100 ++ ++ +G+G+ G V T + A+K L + Q V K+ E ++++ VN Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR---AYREFKLMKLVN 101 Query: 101 FPFLVKLEYSFKDNSNL------YMVMEYVPGGEMFSHLRRIGRFSEPHAR--FYAAQIV 152 ++ L +F NL Y+VME M ++L ++ + H R + Q++ Sbjct: 102 HKNIIGLLNAFTPQRNLEEFQDVYLVMEL-----MDANLCQVIQMDLDHDRMSYLLYQML 156 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLAPE 209 ++LHS +I+RDLKP N+++ +++ DFG A R G T+ + T Y APE Sbjct: 157 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLA-RTAGTTFMMTPYVVTRYYRAPE 215 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDL 269 +IL GY + VD W++G ++ EM G F I + KI+ F L+ Sbjct: 216 VILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 275 Query: 270 LRNLLQ 275 +RN ++ Sbjct: 276 VRNYVE 281 >5B2L-A nrPDB Length = 324 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 66/256 (25%), Positives = 128/256 (50%), Gaps = 15/256 (5%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 A ++ E + +G+G+ G+V ++ ++TG+ A+K + ++ K + ++ +L++ Sbjct: 14 AEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQM-RRSGNKEENKRILMDLDVVLKS 72 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + P++V+ +F N+++++ ME + R G E IV YL Sbjct: 73 HDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYL 132 Query: 159 -HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEII--- 211 +I+RD+KP N+L+D++G I++ DFG + R+ K +T + G Y+APE I Sbjct: 133 KEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPP 191 Query: 212 --LSKGYNKAVDWWALGVLIYEMAAGYPPF-FADQPIQIYEKIVSGKVR-FPSH--FSSD 265 Y+ D W+LG+ + E+A G P+ ++ K++ + P H FS D Sbjct: 192 DPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGD 251 Query: 266 LKDLLRNLLQVDLTKR 281 + +++ L D KR Sbjct: 252 FQSFVKDCLTKDHRKR 267 >4HVI-A nrPDB Length = 314 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 104/204 (50%), Gaps = 26/204 (12%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT--------LNEKRILQA 98 I LG G+FG V L ++ G+ + +V +KQ++H+ E +IL+A Sbjct: 15 ISQLGKGNFGSVELCRYDPLGD-------NTGALVAVKQLQHSGPDQQRDFQREIQILKA 67 Query: 99 VNFPFLVK---LEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLT 154 ++ F+VK + Y +L +VMEY+P G + L+R R Y++QI Sbjct: 68 LHSDFIVKYRGVSYG-PGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKG 126 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GRTWTLCGTPE-----YLAP 208 EYL S ++RDL N+L++ + ++++ DFG AK + + + + P + AP Sbjct: 127 MEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAP 186 Query: 209 EIILSKGYNKAVDWWALGVLIYEM 232 E + +++ D W+ GV++YE+ Sbjct: 187 ESLSDNIFSRQSDVWSFGVVLYEL 210 >5TUR-A nrPDB Length = 404 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 71/265 (26%), Positives = 129/265 (48%), Gaps = 20/265 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN---EKRILQAV 99 Q++ LG+G FG V A+K ++K ++ ++ + E +L+ V Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 100 N--FPFLVKLEYSFKDNSNLYMVMEYV-PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + F +++L F+ + +++E P ++F + G E AR + Q++ Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 247 Query: 157 YLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTWT-LCGTPEYLAPEIILSK 214 + H+ +++RD+K EN+LID +G +++ DFG +K +T GT Y PE I Sbjct: 248 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 307 Query: 215 GYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 Y+ ++ W+LG+L+Y+M G PF D E+I+ G+V F SS+ + L+R Sbjct: 308 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 361 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWF 298 L + + R +I+NH W Sbjct: 362 LALRPSDR-----PTFEEIQNHPWM 381 >3OZ6-A nrPDB Length = 388 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 71/262 (27%), Positives = 120/262 (45%), Gaps = 58/262 (22%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL--------DKQK-------VVKLKQ 85 L ++E +K LG G++G V + TG A+K + D Q+ + +L Sbjct: 8 LRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 86 IEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP-HA 144 E+ +N +L+A N + ++Y+V +Y+ E H EP H Sbjct: 68 HENIVNLLNVLRADN-------------DRDVYLVFDYM---ETDLHAVIRANILEPVHK 111 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR-VKGRTWT----- 198 ++ Q++ +YLHS L++RD+KP N+L++ + +++V DFG ++ V R T Sbjct: 112 QYVVYQLIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPL 171 Query: 199 ------------------LCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 239 T Y APEI+L S Y K +D W+LG ++ E+ G P F Sbjct: 172 SINENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIF 231 Query: 240 FADQPIQIYEKIVSGKVRFPSH 261 + E+I+ G + FPS+ Sbjct: 232 PGSSTMNQLERII-GVIDFPSN 252 >6NPU-A nrPDB Length = 298 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 68/262 (25%), Positives = 121/262 (46%), Gaps = 21/262 (8%) Query: 36 QNTAHLDQFERIKT-------LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 Q + + D++E +T LG G +G V K+ A+K L + + ++E Sbjct: 13 QGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEE 68 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA---R 145 L E +++ + P LV+L Y++ E++ G + +LR R E +A Sbjct: 69 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLL 127 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY 205 + A QI EYL + I+RDL N L+ + ++V DFG ++ + G T+T ++ Sbjct: 128 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKF 187 Query: 206 ----LAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFP 259 APE + ++ D WA GVL++E+A G P+ Q+YE + ++ P Sbjct: 188 PIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERP 247 Query: 260 SHFSSDLKDLLRNLLQVDLTKR 281 + +L+R Q + + R Sbjct: 248 EGCPEKVYELMRACWQWNPSDR 269 >5AIR-A nrPDB Length = 430 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 116/224 (51%), Gaps = 25/224 (11%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + K +G GSFG V K ++G A+K KV++ K+ ++ E +I++ ++ Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIK-----KVLQDKRFKN--RELQIMRKLDHCN 118 Query: 104 LVKLEYSF------KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP----HARFYAAQIVL 153 +V+L Y F KD L +V++YVP ++ R R + + + Y Q+ Sbjct: 119 IVRLRYFFYSSGEKKDEVYLNLVLDYVPE-TVYRVARHYSRAKQTLPVIYVKLYMYQLFR 177 Query: 154 TFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKR-VKGRTWT--LCGTPEYLAPE 209 + Y+HS + +RD+KP+NLL+D +++ DFG AK+ V+G +C Y APE Sbjct: 178 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAPE 236 Query: 210 IIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI-QIYEKI 251 +I + Y ++D W+ G ++ E+ G P F D + Q+ E I Sbjct: 237 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 280 >3HKO-A nrPDB Length = 345 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 72/295 (24%), Positives = 130/295 (44%), Gaps = 57/295 (19%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKL--KQIEHTLNEKRILQAVNFPFLVK 106 +G GS+G V + +T A+KI++K K+ ++ K +E E R+++ ++ P + + Sbjct: 33 AIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIAR 92 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLR-----RIGRFS--------------------- 140 L ++D + +VME GG + L G+ + Sbjct: 93 LYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAING 152 Query: 141 --------------EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLL--IDQQGYIQVT 184 E QI YLH+ + +RD+KPEN L ++ I++ Sbjct: 153 SIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLV 212 Query: 185 DFGFAKRV----KGRTW---TLCGTPEYLAPEII--LSKGYNKAVDWWALGVLIYEMAAG 235 DFG +K G + T GTP ++APE++ ++ Y D W+ GVL++ + G Sbjct: 213 DFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMG 272 Query: 236 YPPFFADQPIQIYEKIVSGKVRF--PSH--FSSDLKDLLRNLLQVDLTKRFGNLK 286 PF ++++ K+ F P++ S +DLL NLL ++ +RF ++ Sbjct: 273 AVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMR 327 >5VD3-A nrPDB Length = 311 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 75/271 (27%), Positives = 129/271 (47%), Gaps = 23/271 (8%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQ-FERIKTLGTGSFGRVMLVKHKETGNHFAMKIL-- 75 F +A E +P++ + Q F+R+ LG GS+G V V+ KE G +A+K Sbjct: 33 FRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMS 92 Query: 76 ----DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 K + KL ++ + +++ Q P V+LE ++++ LY+ E G + Sbjct: 93 PFRGPKDRARKLAEVG---SHEKVGQ---HPCCVRLEQAWEEGGILYLQTELC-GPSLQQ 145 Query: 132 HLRRIGRFSEPHARF--YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA 189 H G S P A+ Y +L +LHS L++ D+KP N+ + +G ++ DFG Sbjct: 146 HCEAWGA-SLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLL 204 Query: 190 KRV--KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYP-PFFADQPIQ 246 + G G P Y+APE +L Y A D ++LG+ I E+A P + Q Sbjct: 205 VELGTAGAGEVQEGDPRYMAPE-LLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQ 263 Query: 247 IYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 277 + + + + F + SS+L+ +L +L+ D Sbjct: 264 LRQGYLPPE--FTAGLSSELRSVLVMMLEPD 292 >3DAK-A nrPDB Length = 290 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 57/224 (25%), Positives = 103/224 (45%), Gaps = 21/224 (9%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D +E + +G+G+ V A+K ++ +K ++ L E + + + Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKC--QTSMDELLKEIQAMSQCHH 67 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI--------GRFSEPHARFYAAQIVL 153 P +V SF L++VM+ + GG + ++ I G E +++ Sbjct: 68 PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLE 127 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA---------KRVKGRTWTLCGTPE 204 EYLH I+RD+K N+L+ + G +Q+ DFG + R K R T GTP Sbjct: 128 GLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRK-TFVGTPC 186 Query: 205 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 ++APE++ +GY+ D W+ G+ E+A G P+ P+++ Sbjct: 187 WMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKV 230 >1K9A-A nrPDB Length = 450 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 63/264 (23%), Positives = 121/264 (45%), Gaps = 14/264 (5%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 ++ + + ++T+G G FG VML ++ GN A+K + + L E ++ + Sbjct: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQL 243 Query: 100 NFPFLVKL-EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFE 156 LV+L ++ LY+V EY+ G + +LR GR ++ + E Sbjct: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGY 216 YL + ++RDL N+L+ + +V+DFG K T ++ APE + K + Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 Query: 217 NKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLL 274 + D W+ G+L++E+ + G P+ + ++ G K+ P + D+++N Sbjct: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 Query: 275 QVDLTKR--FGNLKNGVNDIKNHK 296 +D R F L+ + I+ H+ Sbjct: 424 HLDAATRPTFLQLREQLEHIRTHE 447 >5DBX-A nrPDB Length = 328 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 103/224 (45%), Gaps = 21/224 (9%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D +E + +G+G+ V K A+K ++ +K ++ L E + + + Sbjct: 11 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKC--QTSMDELLKEIQAMSQCSH 68 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI--------GRFSEPHARFYAAQIVL 153 P +V SF L++VM+ + GG M ++ I G E +++ Sbjct: 69 PNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLE 128 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA---------KRVKGRTWTLCGTPE 204 +YLH I+RDLK N+L+ + G +Q+ DFG + R K R GTP Sbjct: 129 GLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRK-DFVGTPC 187 Query: 205 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 ++APE++ +GY+ D W+ G+ E+A G P+ P+++ Sbjct: 188 WMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKV 231 >5HVK-A nrPDB Length = 315 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 102/206 (49%), Gaps = 23/206 (11%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT-LNEKRILQAVNFPFLVK 106 + LG G FG+ + V H+ETG MK L + ++ + T L E ++++ + P ++K Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFD----EETQRTFLKEVKVMRCLEHPNVLK 75 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 + L + EY+ GG + ++ + ++ +A I YLHS+++I+ Sbjct: 76 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRV-----------------KGRTWTLCGTPEYLAP 208 R+L N L+ + + V DFG A+ + + + +T+ G P ++AP Sbjct: 136 RNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 195 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAA 234 E+I + Y++ VD ++ G+++ E+ Sbjct: 196 EMINGRSYDEKVDVFSFGIVLCEIIG 221 >3E3P-A nrPDB Length = 360 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/255 (29%), Positives = 128/255 (50%), Gaps = 37/255 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ--- 97 +D+F+ + G G+FG V L K K TG A+K KV++ + + E +I+Q Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIK-----KVIQDPRFRN--RELQIMQDLA 74 Query: 98 AVNFPFLVKLEYSF-----KDNSNLYM--VMEYVPGGEMFSHLRRIGRFSEPHA---RFY 147 ++ P +V+L+ F +D ++Y+ VMEYVP R P + + Sbjct: 75 VLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVF 134 Query: 148 AAQIVLTFEYLH--SLDLIYRDLKPENLLIDQ-QGYIQVTDFGFAKRV---KGRTWTLCG 201 Q++ + LH S+++ +RD+KP N+L+++ G +++ DFG AK++ + +C Sbjct: 135 LFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICS 194 Query: 202 TPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI-QIYE--KIVSGKVR 257 Y APE+I ++ Y AVD W++G + EM G P F D Q++E +++ R Sbjct: 195 R-YYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSR 253 Query: 258 ------FPSHFSSDL 266 PSH DL Sbjct: 254 EVLRKLNPSHTDVDL 268 >5EFQ-A nrPDB Length = 347 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 116/234 (49%), Gaps = 32/234 (13%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK--ILDKQK----------VVKLKQIEH 88 +D+F+ I +G G++G+V + K+TG A+K LD +K + L+Q+ H Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 89 --TLNEKRIL----QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP 142 +N K I+ A++F KD Y+V EY+ M + F+E Sbjct: 70 QSIINMKEIVTDKEDALDFK---------KDKGAFYLVFEYMDHDLMGLLESGLVHFNEN 120 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWT- 198 H + + Q++ +Y H + ++RD+K N+L++ +G I++ DFG A+ + R +T Sbjct: 121 HIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTN 180 Query: 199 LCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 251 T Y PE++L + Y A+D W+ G ++ E+ P F A+Q + E I Sbjct: 181 KVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELI 234 >4XEY-B nrPDB Length = 408 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/241 (26%), Positives = 112/241 (46%), Gaps = 14/241 (5%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G +G V K+ A+K L + + ++E L E +++ + P LV+L Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLG 188 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA---RFYAAQIVLTFEYLHSLDLIYR 166 Y++ E++ G + +LR R E +A + A QI EYL + I+R Sbjct: 189 VCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMATQISSAMEYLEKKNFIHR 247 Query: 167 DLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY----LAPEIILSKGYNKAVDW 222 DL N L+ + ++V DFG ++ + G T+T ++ APE + ++ D Sbjct: 248 DLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDV 307 Query: 223 WALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTK 280 WA GVL++E+A G P+ Q+YE + ++ P + +L+R Q + + Sbjct: 308 WAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSD 367 Query: 281 R 281 R Sbjct: 368 R 368 >4NST-A nrPDB Length = 351 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 66/225 (29%), Positives = 111/225 (49%), Gaps = 32/225 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK--ILDKQK----------VVKLKQIEH 88 +D+F+ I +G G++G+V K K+TG A+K LD +K + L+Q+ H Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 89 --TLNEKRIL----QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP 142 +N K I+ A++F KD Y+V EY+ M + FSE Sbjct: 72 RSVVNMKEIVTDKQDALDFK---------KDKGAFYLVFEYMDHDLMGLLESGLVHFSED 122 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWT- 198 H + + Q++ EY H + ++RD+K N+L++ G I++ DFG A+ + R +T Sbjct: 123 HIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTN 182 Query: 199 LCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFAD 242 T Y PE++L + Y A+D W+ G ++ E+ P F A+ Sbjct: 183 KVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 227 >4UY9-A nrPDB Length = 323 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 120/269 (44%), Gaps = 22/269 (8%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ-IEHTLNEKRILQAVNFPFLVK 106 + +G G FG+V + G+ A+K + Q IE+ E ++ + P ++ Sbjct: 15 EIIGIGGFGKVY--RAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 72 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF-YAAQIVLTFEYLHS---LD 162 L NL +VME+ GG + L G+ P +A QI YLH + Sbjct: 73 LRGVCLKEPNLCLVMEFARGGPLNRVLS--GKRIPPDILVNWAVQIARGMNYLHDEAIVP 130 Query: 163 LIYRDLKPENLLIDQQ--------GYIQVTDFGFAKRVKGRT-WTLCGTPEYLAPEIILS 213 +I+RDLK N+LI Q+ +++TDFG A+ T + GT ++APE+I + Sbjct: 131 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRA 190 Query: 214 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF--PSHFSSDLKDLLR 271 ++K D W+ GVL++E+ G PF + + + K+ PS L+ Sbjct: 191 SMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLME 250 Query: 272 NLLQVDLTKR--FGNLKNGVNDIKNHKWF 298 + D R F N+ + + I+ +F Sbjct: 251 DCWNPDPHSRPSFTNILDQLTTIEESGFF 279 >1UA2-A nrPDB Length = 346 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 107/220 (48%), Gaps = 16/220 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ-IEHT-LNEKRILQAVN 100 ++E++ LG G F V + K T A+K + + K I T L E ++LQ ++ Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-----FSEPHARFYAAQIVLTF 155 P ++ L +F SN+ +V ++ M + L I + + H + Y + Sbjct: 71 HPNIIGLLDAFGHKSNISLVFDF-----METDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWT-LCGTPEYLAPEIIL 212 EYLH +++RDLKP NLL+D+ G +++ DFG AK R +T T Y APE++ Sbjct: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Query: 213 -SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 251 ++ Y VD WA+G ++ E+ P D + +I Sbjct: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI 225 >1BYG-A nrPDB Length = 278 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 63/264 (23%), Positives = 121/264 (45%), Gaps = 14/264 (5%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 ++ + + ++T+G G FG VML ++ GN A+K + + L E ++ + Sbjct: 19 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQL 71 Query: 100 NFPFLVKL-EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFE 156 LV+L ++ LY+V EY+ G + +LR GR ++ + E Sbjct: 72 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 131 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGY 216 YL + ++RDL N+L+ + +V+DFG K T ++ APE + K + Sbjct: 132 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 191 Query: 217 NKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLL 274 + D W+ G+L++E+ + G P+ + ++ G K+ P + ++++N Sbjct: 192 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCW 251 Query: 275 QVDLTKR--FGNLKNGVNDIKNHK 296 +D R F L+ + IK H+ Sbjct: 252 HLDAAMRPSFLQLREQLEHIKTHE 275 >1CM8-A nrPDB Length = 367 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 59/235 (25%), Positives = 111/235 (47%), Gaps = 18/235 (7%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMK---------ILDKQKVVKLKQIEHTLNEKR 94 + ++ +G+G++G V TG A+K + K+ +L+ ++H +E Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 95 I-LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 I L V P + + D ++ Y+VM ++ G L + + E +F Q++ Sbjct: 87 IGLLDVFTP-----DETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLK 139 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS 213 Y+H+ +I+RDLKP NL +++ +++ DFG A++ T Y APE+IL+ Sbjct: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILN 199 Query: 214 -KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 267 Y + VD W++G ++ EM G F + ++I+ P+ F L+ Sbjct: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 >5X5O-A nrPDB Length = 310 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 64/249 (25%), Positives = 110/249 (44%), Gaps = 21/249 (8%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D + + G GSFG V + K + + K V +K++ E IL ++ Sbjct: 15 DDLQFFENCGGGSFGSV-----------YRAKWISQDKEVAVKKLLKIEKEAEILSVLSH 63 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARFYAAQIVLTFEYLH 159 +++ + N +V EY G ++ ++ R H +A + YLH Sbjct: 64 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 123 Query: 160 ---SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSK 214 + +I+RDLK N++I G +++ DFG A R T +L GT ++APE+I S Sbjct: 124 MEAPVKVIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVIQSL 182 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF--PSHFSSDLKDLLRN 272 ++ D ++ GV+++EM PF + +Q+ +V R PS +LL Sbjct: 183 PVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQ 242 Query: 273 LLQVDLTKR 281 + D KR Sbjct: 243 CWEADAKKR 251 >2FO0-A nrPDB Length = 495 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 112/241 (46%), Gaps = 14/241 (5%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G +G V K+ A+K L + + ++E L E +++ + P LV+L Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLG 280 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA---RFYAAQIVLTFEYLHSLDLIYR 166 Y++ E++ G + +LR R E +A + A QI EYL + I+R Sbjct: 281 VCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMATQISSAMEYLEKKNFIHR 339 Query: 167 DLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY----LAPEIILSKGYNKAVDW 222 +L N L+ + ++V DFG ++ + G T+T ++ APE + ++ D Sbjct: 340 NLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDV 399 Query: 223 WALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTK 280 WA GVL++E+A G P+ Q+YE + ++ P + +L+R Q + + Sbjct: 400 WAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSD 459 Query: 281 R 281 R Sbjct: 460 R 460 >3E7O-A nrPDB Length = 360 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 66/252 (26%), Positives = 121/252 (48%), Gaps = 30/252 (11%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK------------QKVVKLKQIEH 88 L +++++K +G+G+ G V G + A+K L + +++V LK + H Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--F 146 K I+ +N K F+D +Y+VME M ++L ++ H R + Sbjct: 81 ----KNIISLLNVFTPQKTLEEFQD---VYLVMEL-----MDANLCQVIHMELDHERMSY 128 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TP 203 Q++ ++LHS +I+RDLKP N+++ +++ DFG A R + + T Sbjct: 129 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTASTNFMMTPYVVTR 187 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS 263 Y APE+IL GY + VD W++G ++ E+ G F I + K++ + F Sbjct: 188 YYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFM 247 Query: 264 SDLKDLLRNLLQ 275 + L+ +RN ++ Sbjct: 248 AALQPTVRNYVE 259 >4CSV-A nrPDB Length = 275 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 112/249 (44%), Gaps = 18/249 (7%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT 89 KWE P ER LG+G FG V K + A+K L + + +E Sbjct: 5 KWEIPRSEIT----LER--KLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTM----SVEEF 54 Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARF-Y 147 L E +I++ + P LV+L +Y++ EY+ G + +LR G A Sbjct: 55 LQEAQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDM 114 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY-- 205 AAQ+ YL S + I+RDL N L+ + ++V DFG A+ + +T ++ Sbjct: 115 AAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPI 174 Query: 206 --LAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSG-KVRFPSH 261 APE I ++ D WA G+L++E+ G P+ ++ E++ G ++ P Sbjct: 175 KWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQG 234 Query: 262 FSSDLKDLL 270 ++ +L+ Sbjct: 235 CPEEIYELM 243 >5G6V-A nrPDB Length = 324 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 104/211 (49%), Gaps = 22/211 (10%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH-------TLNEK 93 ++ + ++ LG G++ V K K T N A+K + ++EH + E Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEI---------RLEHEEGAPCTAIREV 51 Query: 94 RILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH-ARFYAAQIV 152 +L+ + +V L +L +V EY+ ++ +L G H + + Q++ Sbjct: 52 SLLKDLKHANIVTLHDIIHTEKSLTLVFEYL-DKDLKQYLDDCGNIINMHNVKLFLFQLL 110 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF--AKRVKGRTW-TLCGTPEYLAPE 209 Y H +++RDLKP+NLLI+++G +++ DFG AK + +T+ T Y P+ Sbjct: 111 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPD 170 Query: 210 IIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 239 I+L S Y+ +D W +G + YEMA G P F Sbjct: 171 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLF 201 >4JLC-A nrPDB Length = 657 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 119/233 (51%), Gaps = 33/233 (14%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G+ V +HK+TG+ +A+K+ + + L+ ++ + E +L+ +N +VKL + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKL-F 72 Query: 110 SFKDNSNL---YMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAA--QIVLTFEYLHSLDL 163 + ++ + ++ME+ P G +++ L + P + F +V +L + Sbjct: 73 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 132 Query: 164 IYRDLKPENLLI----DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI----ILS 213 ++RD+KP N++ D Q ++TDFG A+ ++ + +L GT EYL P++ +L Sbjct: 133 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 192 Query: 214 KGYNK----AVDWWALGVLIYEMAAGYPPFFADQPI-------QIYEKIVSGK 255 K + K VD W++GV Y A G PF +P ++ KI++GK Sbjct: 193 KDHQKKYGATVDLWSVGVTFYHAATGSLPF---RPFEGPRRNKEVMYKIITGK 242 >6NT9-A nrPDB Length = 742 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 119/233 (51%), Gaps = 33/233 (14%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G+ V +HK+TG+ FA+K+ + + L+ ++ + E +L+ +N +VKL + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKL-F 71 Query: 110 SFKDNSNL---YMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAA--QIVLTFEYLHSLDL 163 + ++ + ++ME+ P G +++ L + P + F +V +L + Sbjct: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 Query: 164 IYRDLKPENLLI----DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI----ILS 213 ++R++KP N++ D Q ++TDFG A+ ++ + +L GT EYL P++ +L Sbjct: 132 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 Query: 214 KGYNK----AVDWWALGVLIYEMAAGYPPFFADQPI-------QIYEKIVSGK 255 K + K VD W++GV Y A G PF +P ++ KI++GK Sbjct: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF---RPFEGPRRNKEVMYKIITGK 241 >4EUU-A nrPDB Length = 319 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 119/233 (51%), Gaps = 33/233 (14%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G+ V +HK+TG+ FA+K+ + + L+ ++ + E +L+ +N +VKL + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKL-F 73 Query: 110 SFKDNSNL---YMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAA--QIVLTFEYLHSLDL 163 + ++ + ++ME+ P G +++ L + P + F +V +L + Sbjct: 74 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 164 IYRDLKPENLLI----DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI----ILS 213 ++R++KP N++ D Q ++TDFG A+ ++ + +L GT EYL P++ +L Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 214 KGYNK----AVDWWALGVLIYEMAAGYPPFFADQPI-------QIYEKIVSGK 255 K + K VD W++GV Y A G PF +P ++ KI++GK Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPF---RPFEGPRRNKEVMYKIITGK 243 >4E7W-A nrPDB Length = 394 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 114/224 (50%), Gaps = 26/224 (11%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + K +G GSFG V K E+ + A+K KV++ K+ ++ E +I++ V P Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVES-DEVAIK-----KVLQDKRFKN--RELQIMRIVKHPN 93 Query: 104 LVKLEYSF------KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA----RFYAAQIVL 153 +V L+ F KD L +V+EYVP ++ R + + + Y Q++ Sbjct: 94 VVDLKAFFYSNGDKKDEVFLNLVLEYVPE-TVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 154 TFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPE 209 + Y+HS+ + +RD+KP+NLL+D G +++ DFG AK + + +C Y APE Sbjct: 153 SLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSR-YYRAPE 211 Query: 210 IIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI-QIYEKI 251 +I + Y +D W+ G ++ E+ G P F + I Q+ E I Sbjct: 212 LIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEII 255 >4EUT-A nrPDB Length = 396 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 119/233 (51%), Gaps = 33/233 (14%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G+ V +HK+TG+ FA+K+ + + L+ ++ + E +L+ +N +VKL + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKL-F 73 Query: 110 SFKDNSNL---YMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAA--QIVLTFEYLHSLDL 163 + ++ + ++ME+ P G +++ L + P + F +V +L + Sbjct: 74 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 164 IYRDLKPENLLI----DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI----ILS 213 ++R++KP N++ D Q ++TDFG A+ ++ + +L GT EYL P++ +L Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 214 KGYNK----AVDWWALGVLIYEMAAGYPPFFADQPI-------QIYEKIVSGK 255 K + K VD W++GV Y A G PF +P ++ KI++GK Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPF---RPFEGPRRNKEVMYKIITGK 243 >3DTC-A nrPDB Length = 271 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 62/226 (27%), Positives = 104/226 (46%), Gaps = 18/226 (7%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ-IEHTLNEKRILQAVNFPFLVK 106 + +G G FG+V + G+ A+K + Q IE+ E ++ + P ++ Sbjct: 13 EIIGIGGFGKVY--RAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 70 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF-YAAQIVLTFEYLHS---LD 162 L NL +VME+ GG + L G+ P +A QI YLH + Sbjct: 71 LRGVCLKEPNLCLVMEFARGGPLNRVLS--GKRIPPDILVNWAVQIARGMNYLHDEAIVP 128 Query: 163 LIYRDLKPENLLIDQQ--------GYIQVTDFGFAKRVKGRT-WTLCGTPEYLAPEIILS 213 +I+RDLK N+LI Q+ +++TDFG A+ T + G ++APE+I + Sbjct: 129 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWMAPEVIRA 188 Query: 214 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP 259 ++K D W+ GVL++E+ G PF + + + K+ P Sbjct: 189 SMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP 234 >2A1A-B nrPDB Length = 284 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 104/209 (49%), Gaps = 27/209 (12%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILD------KQKVVKLKQIEHTLNEKRILQ 97 F+ I+ +G+G FG+V KH+ G + +K + +++V L +++H + Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDH-------VN 65 Query: 98 AVNF-----PFLVKLEYSFKDNSN-----LYMVMEYVPGG--EMFSHLRRIGRFSEPHAR 145 V++ F E S K++S L++ ME+ G E + RR + + A Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTP 203 QI +Y+HS LI RDLKP N+ + +++ DFG +K G+ GT Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTL 185 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEM 232 Y++PE I S+ Y K VD +ALG+++ E+ Sbjct: 186 RYMSPEQISSQDYGKEVDLYALGLILAEL 214 >6O8B-A nrPDB Length = 665 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 118/233 (50%), Gaps = 33/233 (14%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G+ V +HK+TG+ FA+K+ + + L+ ++ + E +L+ +N +VKL + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNN--ISFLRPVDVQMREFEVLKKLNHKNIVKL-F 79 Query: 110 SFKDNSNL---YMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAA--QIVLTFEYLHSLDL 163 + ++ + ++ME+ P G +++ L + P + F +V +L + Sbjct: 80 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 139 Query: 164 IYRDLKPENLLI----DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI----ILS 213 ++R++KP N++ D Q ++TDFG A+ ++ + L GT EYL P++ +L Sbjct: 140 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLR 199 Query: 214 KGYNK----AVDWWALGVLIYEMAAGYPPFFADQPI-------QIYEKIVSGK 255 K + K VD W++GV Y A G PF +P ++ KI++GK Sbjct: 200 KDHQKKYGATVDLWSIGVTFYHAATGSLPF---RPFEGPRRNKEVMYKIITGK 249 >4GS6-A nrPDB Length = 315 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 101/210 (48%), Gaps = 28/210 (13%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT------LNEKRIL 96 + E + +G G+FG V K + K V +KQIE + E R L Sbjct: 10 EIEVEEVVGRGAFGVVCKAKWR-------------AKDVAIKQIESESERKAFIVELRQL 56 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR---RIGRFSEPHARFYAAQIVL 153 VN P +VKL Y N + +VMEY GG +++ L + ++ HA + Q Sbjct: 57 SRVNHPNIVKL-YGACLNP-VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 154 TFEYLHSLD---LIYRDLKPENLLIDQQGYI-QVTDFGFAKRVKGRTWTLCGTPEYLAPE 209 YLHS+ LI+RDLKP NLL+ G + ++ DFG A ++ G+ ++APE Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPE 174 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 + Y++ D ++ G++++E+ PF Sbjct: 175 VFEGSNYSEKCDVFSWGIILWEVITRRKPF 204 >6FYV-A nrPDB Length = 337 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 65/226 (28%), Positives = 108/226 (47%), Gaps = 35/226 (15%) Query: 43 QFERIKTLGTGSFGRVM-LVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN- 100 ++E + TLG G+FG+V+ + H G H A+KI+ + V + + E +E ++L+ +N Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIV--KNVGRYR--EAARSEIQVLEHLNS 70 Query: 101 ------FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIV 152 F + LE+ F + ++ +V E + G + ++ F H R A QI Sbjct: 71 TDPNSVFRCVQMLEW-FDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGY-------------------IQVTDFGFAKRVK 193 + +LH L + DLKPEN+L + Y I+V DFG A Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDD 188 Query: 194 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 TL T Y APE+IL+ G+++ D W++G ++ E G+ F Sbjct: 189 EHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVF 234 >2WO6-A nrPDB Length = 382 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/234 (26%), Positives = 113/234 (48%), Gaps = 17/234 (7%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +D++E +G GSFG+V+ + A+KI+ +K + E R+L+ +N Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAF----LNQAQIEVRLLELMN 108 Query: 101 FP------FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIV 152 ++V L+ F ++L +V E + ++ LR S R +A Q+ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEML-SYNLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 153 LTFEYLHS--LDLIYRDLKPENLLI--DQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAP 208 +L + L +I+ DLKPEN+L+ ++ I++ DFG + ++ R + + Y +P Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSP 227 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF 262 E++L Y+ A+D W+LG ++ EM G P F + KIV P+H Sbjct: 228 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI 281 >2XS0-A nrPDB Length = 386 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 112/225 (49%), Gaps = 22/225 (9%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK--------QKVVKLKQIEHTLNE 92 L +++ +K +G+G+ G V + A+K L + ++ + + +N Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--FYAAQ 150 K I+ +N + + S ++ ++Y+VME M ++L ++ + H R + Q Sbjct: 85 KNIIGLLN---VFTPQKSLEEFQDVYIVMEL-----MDANLCQVIQMELDHERMSYLLYQ 136 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLA 207 ++ ++LHS +I+RDLKP N+++ +++ DFG A R G ++ + T Y A Sbjct: 137 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMVPFVVTRYYRA 195 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252 PE+IL GY + VD W++G ++ EM G F I + K++ Sbjct: 196 PEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVI 240 >6DTL-A nrPDB Length = 364 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 99/205 (48%), Gaps = 18/205 (8%) Query: 47 IKTLGTGSFGRVMLVKHKET---------GNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 I +G G++G V + ET N F KI K+ + ++K + H +E + Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIV-- 92 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 A+ L +F D Y +M+ ++ +R SE H +++ QI+ +Y Sbjct: 93 AIRDIIPPPLRNAFNDVYIAYELMD----TDLHQIIRSNQALSEEHCQYFLYQILRGLKY 148 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL--CGTPEYLAPEIIL-SK 214 +HS ++++RDLKP NLL++ +++ DFG A+ + T Y APE++L S Sbjct: 149 IHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSS 208 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPF 239 Y A+D W++G + E+ P F Sbjct: 209 DYTAAIDVWSVGCIFMELMDRKPLF 233 >2I6L-A nrPDB Length = 320 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 27/215 (12%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ +K LG G G V + A+K K + + ++H L E +I++ ++ Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIK---KIVLTDPQSVKHALREIKIIRRLDHD 68 Query: 103 FLVKL--------------EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148 +VK+ S + +++Y+V EY+ +++ G E HAR + Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETD--LANVLEQGPLLEEHARLFM 126 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI-QVTDFGFAKRV------KGRTWTLCG 201 Q++ +Y+HS ++++RDLKP NL I+ + + ++ DFG A+ + KG Sbjct: 127 YQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLV 186 Query: 202 TPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAG 235 T Y +P ++LS Y KA+D WA G + EM G Sbjct: 187 TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTG 221 >1JNK-A nrPDB Length = 423 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 63/248 (25%), Positives = 117/248 (47%), Gaps = 22/248 (8%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK--------QKVVKLKQIEHTLNE 92 L +++ +K +G+G+ G V + A+K L + ++ + + +N Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--FYAAQ 150 K I+ +N K F+D +Y+VME M ++L ++ + H R + Q Sbjct: 121 KNIISLLNVFTPQKTLEEFQD---VYLVMEL-----MDANLCQVIQMELDHERMSYLLYQ 172 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLA 207 ++ ++LHS +I+RDLKP N+++ +++ DFG A R G ++ + T Y A Sbjct: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRA 231 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 267 PE+IL GY + VD W++G ++ EM F I + K++ F L+ Sbjct: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 Query: 268 DLLRNLLQ 275 +RN ++ Sbjct: 292 PTVRNYVE 299 >4QNY-A nrPDB Length = 354 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 109/220 (49%), Gaps = 13/220 (5%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHF-AMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ERI +G GS+G V+ + ++ N AMK ++K+ ++ + L E ++L N Sbjct: 24 LERI--IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDD 81 Query: 103 FLVKLE--YSFKDNSNL---YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 ++ L + +D N Y+VM+ + ++ LR +E H +F+ Q + Sbjct: 82 NIIGLRNILTPEDPENFDHFYIVMD-IMETDLKQVLRSGQELTEAHIQFFIYQALRALHI 140 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPE-YLAPEIIL-S 213 +HS +I+RD+ P N+L++ +++ DFG AK +G T T Y APE+++ Sbjct: 141 IHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMED 200 Query: 214 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253 K Y+ +D W +G ++ E+ P F + +KIV Sbjct: 201 KDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVD 240 >2F9G-A nrPDB Length = 353 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 109/220 (49%), Gaps = 33/220 (15%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK--QKVVKLKQIEHTLNEKRIL----- 96 F+ LG G++G V HK TG A+K ++ + + L+ TL E +IL Sbjct: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR----TLREIKILKHFKH 68 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI---GRFSEPHARFYAAQIVL 153 + + F ++ SF++ + +Y++ E M + L R+ S+ H +++ Q + Sbjct: 69 ENIITIFNIQRPDSFENFNEVYIIQEL-----MQTDLHRVISTQMLSDDHIQYFIYQTLR 123 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR-------TWTLCGTPEYL 206 + LH ++I+RDLKP NLLI+ ++V DFG A+ + T G EY+ Sbjct: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 Query: 207 ------APEIILSKG-YNKAVDWWALGVLIYEMAAGYPPF 239 APE++L+ Y++A+D W+ G ++ E+ P F Sbjct: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 >3FI2-A nrPDB Length = 353 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 63/248 (25%), Positives = 117/248 (47%), Gaps = 22/248 (8%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK--------QKVVKLKQIEHTLNE 92 L +++ +K +G+G+ G V + A+K L + ++ + + +N Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--FYAAQ 150 K I+ +N K F+D +Y+VME M ++L ++ + H R + Q Sbjct: 83 KNIISLLNVFTPQKTLEEFQD---VYLVMEL-----MDANLCQVIQMELDHERMSYLLYQ 134 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLA 207 ++ ++LHS +I+RDLKP N+++ +++ DFG A R G ++ + T Y A Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRA 193 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 267 PE+IL GY + VD W++G ++ EM F I + K++ F L+ Sbjct: 194 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 253 Query: 268 DLLRNLLQ 275 +RN ++ Sbjct: 254 PTVRNYVE 261 >5UNP-A nrPDB Length = 369 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 102/226 (45%), Gaps = 33/226 (14%) Query: 42 DQFERIKTLGTGSFGRVM-LVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +++E + TLG G+FGRV+ V H+ G A+KI+ + V K K+ E +L+ +N Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKII--KNVEKYKEAARL--EINVLEKIN 89 Query: 101 FP------FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP--HARFYAAQIV 152 V++ F + ++ + E + G F L+ P R A Q+ Sbjct: 90 EKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLC 148 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGY-------------------IQVTDFGFAKRVK 193 ++LH L + DLKPEN+L Y ++V DFG A Sbjct: 149 QAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDH 208 Query: 194 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 T+ T Y APE+IL G+++ D W++G +I+E G+ F Sbjct: 209 EHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLF 254 >4G3E-A nrPDB Length = 352 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 99/199 (49%), Gaps = 17/199 (8%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 +G GSFG V +K K+TG A+K K++ + E ++ P +V L Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVK--------KVRLEVFRVEELVACAGLSSPRIVPLYG 133 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 169 + ++ + + ME + GG + ++++G E A +Y Q + EYLH+ +++ D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVK 193 Query: 170 PENLLIDQQGY-IQVTDFGFAKRVK----GRTWT----LCGTPEYLAPEIILSKGYNKAV 220 +N+L+ G + DFG A ++ G++ + GT ++APE+++ K + V Sbjct: 194 ADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKV 253 Query: 221 DWWALGVLIYEMAAGYPPF 239 D W+ ++ M G P+ Sbjct: 254 DIWSSCCMMLHMLNGCHPW 272 >4O2Z-A nrPDB Length = 377 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 17/210 (8%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMK--------ILDKQKVVKLKQIEHTLNEKR 94 ++ +K LG G++G +TG ++K + D ++V++ + + + Sbjct: 46 KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHEN 105 Query: 95 ILQAVNFPFLVKLEY-SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 +L VN +K EY SF+D + +M+ +M LR E H +++ QI+ Sbjct: 106 LLNVVNILPPLKREYHSFEDVYVVTPLMDV----DMNVVLRSRQVLEESHMQYFVYQILR 161 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLAPEI 210 +YLHS ++ +RDLKP NL+ + +++ DFG ++ V L T Y PE+ Sbjct: 162 GLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPEL 221 Query: 211 IL-SKGYNKAVDWWALGVLIYEMAAGYPPF 239 +L + Y+ AVD W++G + EM P F Sbjct: 222 LLENTNYSTAVDIWSVGCIFAEMYNRKPVF 251 >4QTB-A nrPDB Length = 380 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 102/213 (47%), Gaps = 24/213 (11%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH------TLNEKRIL 96 ++ +++ +G G++G V A+K K+ EH TL E +IL Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK--------KISPFEHQTYCQRTLREIQIL 93 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI---GRFSEPHARFYAAQIVL 153 ++ + + ++ M Y+ M + L ++ + S H ++ QI+ Sbjct: 94 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILR 153 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV------KGRTWTLCGTPEYLA 207 +Y+HS ++++RDLKP NLLI+ +++ DFG A+ G T Y A Sbjct: 154 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 213 Query: 208 PEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 239 PEI+L SKGY K++D W++G ++ EM + P F Sbjct: 214 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 246 >5AMN-A nrPDB Length = 299 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 70/281 (24%), Positives = 125/281 (44%), Gaps = 44/281 (15%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKL------ 83 KWE P +N KTLG G FG+V+ K T H + VK+ Sbjct: 17 KWEFPRKNLV------LGKTLGEGEFGKVV----KATAFHLKGRAGYTTVAVKMLKENAS 66 Query: 84 -KQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE- 141 ++ L+E +L+ VN P ++KL + + L +++EY G + LR + Sbjct: 67 PSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPG 126 Query: 142 -PHARF--------YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFG----- 187 P R +A QI +YL + L++RDL N+L+ + ++++DFG Sbjct: 127 YPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV 186 Query: 188 -----FAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFA 241 + KR +GR +++A E + Y D W+ GVL++E+ G P+ Sbjct: 187 YEEDSYVKRSQGRI-----PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 241 Query: 242 DQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 P +++ + +G ++ P + S ++ L+ + + KR Sbjct: 242 IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 282 >4Y93-A nrPDB Length = 446 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/227 (26%), Positives = 112/227 (49%), Gaps = 15/227 (6%) Query: 47 IKTLGTGSFGRVMLVKHKETGNH-FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV 105 +K LGTG FG V K + G + A+K++ + + + + IE E +++ ++ LV Sbjct: 193 LKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIE----EAKVMMNLSHEKLV 246 Query: 106 KLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLI 164 +L ++++ EY+ G + ++LR + RF + EYL S + Sbjct: 247 QLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFL 306 Query: 165 YRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY----LAPEIILSKGYNKAV 220 +RDL N L++ QG ++V+DFG + V +T ++ +PE+++ ++ Sbjct: 307 HRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKS 366 Query: 221 DWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKVRFP-SHFSSD 265 D WA GVL++E+ + G P+ + E I G +R P H +S+ Sbjct: 367 DIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQG-LRLPRPHLASE 412 >4XI2-A nrPDB Length = 446 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 109/225 (48%), Gaps = 11/225 (4%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 +K LGTG FG V K + + A+K++ + + + + IE E +++ ++ LV+ Sbjct: 192 LKELGTGQFGVVKYGKWRGQYD-VAIKMIREGSMSEDEFIE----EAKVMMNLSHEKLVQ 246 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 L ++++ EY+ G + ++LR + RF + EYL S ++ Sbjct: 247 LYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLH 306 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLA----PEIILSKGYNKAVD 221 RDL N L++ QG ++V+DFG ++ V +T ++ PE+++ ++ D Sbjct: 307 RDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSD 366 Query: 222 WWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSD 265 WA GVL++E+ + G P+ + E I G + H +S+ Sbjct: 367 IWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE 411 >5O0Y-A nrPDB Length = 579 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 65/197 (32%), Positives = 98/197 (49%), Gaps = 26/197 (13%) Query: 88 HTLNEKRILQAVNFPFLVKL-EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 146 H E RI + ++ P +VKL +Y D + V+EY G ++ +L++ SE AR Sbjct: 334 HACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARS 393 Query: 147 YAAQIVLTFEYLHSLD--LIYRDLKPENLLI---DQQGYIQVTDFGFAK--------RVK 193 QIV +YL+ + +I+ DLKP N+L+ G I++TDFG +K V Sbjct: 394 IIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVD 453 Query: 194 GRTWTL--CGTPEYLAPEIIL-----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 246 G T GT YL PE + K NK VD W++GV+ Y+ G PF +Q Q Sbjct: 454 GMELTSQGAGTYWYLPPECFVVGKEPPKISNK-VDVWSVGVIFYQCLYGRKPFGHNQSQQ 512 Query: 247 --IYEKIV--SGKVRFP 259 + E + + +V+FP Sbjct: 513 DILQENTILKATEVQFP 529 >6E4F-A nrPDB Length = 290 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 109/225 (48%), Gaps = 11/225 (4%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 +K LGTG FG V K + + A+K++ + + + + IE E +++ ++ LV+ Sbjct: 36 LKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIE----EAKVMMNLSHEKLVQ 90 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 L ++++ EY+ G + ++LR + RF + EYL S ++ Sbjct: 91 LYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLH 150 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLA----PEIILSKGYNKAVD 221 RDL N L++ QG ++V+DFG ++ V +T ++ PE+++ ++ D Sbjct: 151 RDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSD 210 Query: 222 WWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSD 265 WA GVL++E+ + G P+ + E I G + H +S+ Sbjct: 211 IWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE 255 >3NIZ-A nrPDB Length = 311 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 73/318 (22%), Positives = 133/318 (41%), Gaps = 85/318 (26%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI----------EHTL 90 ++++++++ +G G++G V K + ++V LK+I + Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQG------------RIVALKRIRLDAEDEGIPSTAI 67 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-----GRFSEPHAR 145 E +L+ ++ P +V L L +V E+ M L+++ + + Sbjct: 68 REISLLKELHHPNIVSLIDVIHSERCLTLVFEF-----MEKDLKKVLDENKTGLQDSQIK 122 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGT 202 Y Q++ + H +++RDLKP+NLLI+ G +++ DFG A+ + R++T T Sbjct: 123 IYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVT 182 Query: 203 PEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYP------------------------ 237 Y AP++++ SK Y+ +VD W++G + EM G P Sbjct: 183 LWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPR 242 Query: 238 --------PFFADQPIQIYEK-----IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGN 284 P + + Q++EK I+ G F + DLL N+L D KR Sbjct: 243 EWPQVQELPLWKQRTFQVFEKKPWSSIIPG-------FCQEGIDLLSNMLCFDPNKRI-- 293 Query: 285 LKNGVNDIKNHKWFATTD 302 D NH +F D Sbjct: 294 ---SARDAMNHPYFKDLD 308 >5CEK-A nrPDB Length = 263 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 94/210 (44%), Gaps = 24/210 (11%) Query: 111 FKDNSNLYMVMEYVPG------------GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 +SN+ ++E + G G+M S++R R E A QIV + Sbjct: 57 LPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHC 116 Query: 159 HSLDLIYRDLKPENLL--IDQQGYIQVTDFGFAKRVKGRTWTLC---GTPEYLAPEIILS 213 H ++ DLK + +++ +++ +KG L G P Y++PEI+ + Sbjct: 117 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNT 176 Query: 214 KGY--NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 G KA D W+LGV++Y + G PF P ++ KI G+ P H S + L+R Sbjct: 177 TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIR 236 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 +LL+ + ++R +I H WF + Sbjct: 237 SLLRREPSERL-----TAPEILLHPWFESV 261 >5NGU-A nrPDB Length = 381 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 40/114 (35%), Positives = 64/114 (56%), Gaps = 7/114 (6%) Query: 133 LRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV 192 L + S H ++ QI+ +Y+HS ++++RDLKP NLL++ +++ DFG A+ Sbjct: 134 LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVA 193 Query: 193 ------KGRTWTLCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 239 G T Y APEI+L SKGY K++D W++G ++ EM + P F Sbjct: 194 DPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 247 >6DC0-A nrPDB Length = 292 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 94/210 (44%), Gaps = 24/210 (11%) Query: 111 FKDNSNLYMVMEYVPG------------GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 +SN+ ++E + G G+M S++R R E A QIV + Sbjct: 54 LPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHC 113 Query: 159 HSLDLIYRDLKPENLL--IDQQGYIQVTDFGFAKRVKGRTWTLC---GTPEYLAPEIILS 213 H ++ DLK + +++ +++ +KG L G P Y++PEI+ + Sbjct: 114 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNT 173 Query: 214 KGY--NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 G KA D W+LGV++Y + G PF P ++ KI G+ P H S + L+R Sbjct: 174 TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIR 233 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 +LL+ + ++R +I H WF + Sbjct: 234 SLLRREPSERL-----TAPEILLHPWFESV 258 >1V0B-A nrPDB Length = 288 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 113/221 (51%), Gaps = 20/221 (9%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++++ ++ +G G++G V+ G FA+K + +K + T+ E IL+ + Sbjct: 1 MEKYHGLEKIGEGTYG-VVYKAQNNYGETFALKKIRLEKEDE-GIPSTTIREISILKELK 58 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-----GRFSEPHARFYAAQIVLTF 155 +VKL L +V E++ L+++ G A+ + Q++ Sbjct: 59 HSNIVKLYDVIHTKKRLVLVFEHLD-----QDLKKLLDVCEGGLESVTAKSFLLQLLNGI 113 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIIL 212 Y H +++RDLKP+NLLI+++G +++ DFG A+ + R +T T Y AP++++ Sbjct: 114 AYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLM 173 Query: 213 -SKGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIY 248 SK Y+ +D W++G + EM G P F ADQ ++I+ Sbjct: 174 GSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIF 214 >5VO2-A nrPDB Length = 300 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/248 (25%), Positives = 114/248 (45%), Gaps = 24/248 (9%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 WE P ++ ++ +G+G+ G V L + G A+K K + +K I+H Sbjct: 7 WEVP------FEEILDLQWVGSGAQGAVFLGRFH--GEEVAVK---KVRDLKETDIKH-- 53 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF-YAA 149 L+ + P ++ + ++ME+ G+++ LR GR P ++ Sbjct: 54 -----LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRPVTPSLLVDWSM 107 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLA 207 I YLH +I+RDLK N+LI ++++DFG +K + K + GT ++A Sbjct: 108 GIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMA 167 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF--PSHFSSD 265 PE+I ++ ++ VD W+ GV+++E+ G P+ I + S + PS Sbjct: 168 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDG 227 Query: 266 LKDLLRNL 273 K LLR Sbjct: 228 FKILLRQC 235 >4IDT-A nrPDB Length = 356 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 95/199 (47%), Gaps = 17/199 (8%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG GSFG V ++ K+TG A+K K++ E + P +V L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVK--------KVRLEVFRAEELMACAGLTSPRIVPLYG 133 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 169 + ++ + + ME + GG + ++ G E A +Y Q + EYLHS +++ D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 193 Query: 170 PENLLIDQQG-YIQVTDFGFAKRVK----GRTWT----LCGTPEYLAPEIILSKGYNKAV 220 +N+L+ G + + DFG A ++ G+ + GT ++APE++L + + V Sbjct: 194 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKV 253 Query: 221 DWWALGVLIYEMAAGYPPF 239 D W+ ++ M G P+ Sbjct: 254 DVWSSCCMMLHMLNGCHPW 272 >3UIU-A nrPDB Length = 306 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 100/215 (46%), Gaps = 26/215 (12%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILD------KQKVVKLKQIEHT-------- 89 F+ I+ +G+G FG+V KH+ G + ++ + +++V L +++H Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAEREVKALAKLDHVNIVHYNGC 73 Query: 90 --------LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGG--EMFSHLRRIGRF 139 L++ ++ S L++ ME+ G E + RR + Sbjct: 74 WDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKL 133 Query: 140 SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTW 197 + A QI +Y+HS LI+RDLKP N+ + +++ DFG +K G+ Sbjct: 134 DKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRT 193 Query: 198 TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232 GT Y++PE I S+ Y K VD +ALG+++ E+ Sbjct: 194 RSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL 228 >3EB0-A nrPDB Length = 383 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 70/249 (28%), Positives = 113/249 (45%), Gaps = 50/249 (20%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 KTLGTGSFG V V E+G FA+K + + K ++ L+ ++L VN LV Sbjct: 13 KTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRE----LDIMKVLDHVNIIKLVDY 68 Query: 108 EYSFKD-----------------------------------NSNLYMVMEYVPGG--EMF 130 Y+ D N L ++MEYVP ++ Sbjct: 69 FYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVL 128 Query: 131 SHLRRIGRFSEPH--ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ-GYIQVTDFG 187 R GR S P Y Q+ ++HSL + +RD+KP+NLL++ + +++ DFG Sbjct: 129 KSFIRSGR-SIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFG 187 Query: 188 FAKRV---KGRTWTLCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQ 243 AK++ + +C Y APE++L + Y ++D W++G + E+ G P F + Sbjct: 188 SAKKLIPSEPSVAYICSR-FYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGET 246 Query: 244 PIQIYEKIV 252 I +I+ Sbjct: 247 SIDQLVRII 255 >4UYA-A nrPDB Length = 340 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 61/233 (26%), Positives = 106/233 (45%), Gaps = 21/233 (9%) Query: 44 FERIKT---LGTGSFGRVMLVKHKETGNHFAMKILDKQ-KVVKLKQIEHTLNEKRILQAV 99 FER++ +G G FG+V + G A+K + + E E R+ + Sbjct: 25 FERLELKELIGAGGFGQVY--RATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 82 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF-YAAQIVLTFEYL 158 P +++L +L +V+E+ GG + L GR PH +A QI YL Sbjct: 83 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL--AGRRIPPHVLVNWAVQIARGMLYL 140 Query: 159 HS---LDLIYRDLKPENLLIDQQ--------GYIQVTDFGFAKRVKGRT-WTLCGTPEYL 206 H + +++RDLK N+L+ ++ +++TDFG A+ T G ++ Sbjct: 141 HEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWM 200 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP 259 APE+I S ++K D W+ GVL++E+ G P+ + + + K+ P Sbjct: 201 APEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP 253 >3SXS-A nrPDB Length = 268 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 109/230 (47%), Gaps = 11/230 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++ +K LG+G FG V L K K + A+K++ + + + + E + + ++ Sbjct: 8 EEITLLKELGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSE----DEFFQEAQTMMKLSH 62 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF-YAAQIVLTFEYLHS 160 P LVK +Y+V EY+ G + ++LR G+ EP + +L S Sbjct: 63 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 122 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW-TLCGTP---EYLAPEIILSKGY 216 I+RDL N L+D+ ++V+DFG + V + + GT ++ APE+ Y Sbjct: 123 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKY 182 Query: 217 NKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSD 265 + D WA G+L++E+ + G P+ ++ K+ G + H +SD Sbjct: 183 SSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASD 232 >3VN9-A nrPDB Length = 340 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 70/260 (26%), Positives = 124/260 (47%), Gaps = 28/260 (10%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL----- 96 D E I LG G++G V ++H +G A+K +++ ++ +KR+L Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVK--------RIRATVNSQEQKRLLMDLDI 102 Query: 97 --QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGG--EMFSHLRRIGR-FSEPHARFYAAQI 151 + V+ PF V + ++++ ME + + + + G+ E A I Sbjct: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 Query: 152 VLTFEYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAK-RVKGRTWTL-CGTPEYLAP 208 V E+LHS L +I+RD+KP N+LI+ G +++ DFG + V T+ G Y+AP Sbjct: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 222 Query: 209 EII----LSKGYNKAVDWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIV-SGKVRFPS-H 261 E I KGY+ D W+LG+ + E+A P+ + P Q +++V + P+ Sbjct: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 Query: 262 FSSDLKDLLRNLLQVDLTKR 281 FS++ D L+ + +R Sbjct: 283 FSAEFVDFTSQCLKKNSKER 302 >3LLT-A nrPDB Length = 360 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 105/222 (47%), Gaps = 29/222 (13%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL-DKQKVVKLKQIEHTLNEKRILQAVN 100 + F I+ +G G+FGRV+L +H + ++A+K++ + +K + +IE + +K +N Sbjct: 35 NAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDIN 94 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR--IGRFSEPHARFYAAQIVLTFEYL 158 +VK F ++ ++ E + G ++ + R F + Y +I+ YL Sbjct: 95 NNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 159 HSLDLIYRDLKPENLLIDQQGY-------------------------IQVTDFGFAKRVK 193 + L + DLKPEN+L+D + I++ DFG A Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKS 213 Query: 194 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAG 235 ++ T +Y APE+IL+ G++ + D W+ G ++ E+ G Sbjct: 214 DYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTG 255 >4KRC-A nrPDB Length = 317 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 108/212 (50%), Gaps = 23/212 (10%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT----LNEKRILQA 98 QF++++ LG G++ V +K TG + A+K VKL E T + E +++ Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALK------EVKLDSEEGTPSTAIREISLMKE 59 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGG-EMFSHLRRIGRFSEPHA------RFYAAQI 151 + +V+L + L +V E++ + + R +G + P +++ Q+ Sbjct: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVG--NTPRGLELNLVKYFQWQL 117 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLAP 208 + + H +++RDLKP+NLLI+++G +++ DFG A+ T T Y AP Sbjct: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 209 EIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 239 ++++ S+ Y+ ++D W+ G ++ EM G P F Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 >2PMN-X nrPDB Length = 348 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 60/258 (23%), Positives = 120/258 (46%), Gaps = 42/258 (16%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHF-AMKILDKQKVVKLKQIEHTLNEK----- 93 +++ + I+TL G F +++L E N F A+K +K + K + + N+K Sbjct: 29 YINDYRIIRTLNQGKFNKIILC---EKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKS 85 Query: 94 ---------RILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA 144 +I+ + + + E + +Y++ EY+ + + + Sbjct: 86 KYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYT 145 Query: 145 RFYAAQIVL--------TFEYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFG-----FAK 190 F Q++ +F Y+H+ ++ +RD+KP N+L+D+ G ++++DFG K Sbjct: 146 CFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDK 205 Query: 191 RVKGRTWTLCGTPEYLAPEIILSK-GYNKA-VDWWALGVLIYEMAAGYPPF-FADQPIQI 247 ++KG GT E++ PE ++ YN A VD W+LG+ +Y M PF +++ Sbjct: 206 KIKGSR----GTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVEL 261 Query: 248 YEKIVSGKVRFP---SHF 262 + I + + +P +HF Sbjct: 262 FNNIRTKNIEYPLDRNHF 279 >5Y86-A nrPDB Length = 588 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 107/207 (51%), Gaps = 15/207 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL------DKQKVVKLKQIEHTLNEKRIL 96 ++E +K +G GSFG+V V + + A+K++ +Q +++ +EH L ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEH-LKKQDKT 266 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR--IGRFSEPHARFYAAQIVLT 154 ++N ++ + SF +++ M E + +++ +++ FS R +A I+ + Sbjct: 267 GSMN---VIHMLESFTFRNHVCMAFELL-SIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQG--YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 212 + LH +I+ DLKPEN+L+ G +V DFG + + +T + Y APEIIL Sbjct: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIIL 382 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPF 239 Y+ +D W+ G ++ E+ G P F Sbjct: 383 GSRYSTPIDIWSFGCILAELLTGQPLF 409 >1G3N-A nrPDB Length = 326 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 107/223 (47%), Gaps = 15/223 (6%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFA----MKILDKQKVVKLKQIEHTLNEKRILQA 98 Q+E + +G G++G+V + + G F +++ ++ + L I + R L+ Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIRE-VAVLRHLET 70 Query: 99 VNFPFLVKL----EYSFKDN-SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF--YAAQI 151 P +V+L S D + L +V E+V ++ ++L ++ P Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPE 209 + ++LHS +++RDLKP+N+L+ G I++ DFG A+ + ++ T Y APE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252 ++L Y VD W++G + EM P F + KI+ Sbjct: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 >3QUP-A nrPDB Length = 323 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 71/289 (24%), Positives = 127/289 (43%), Gaps = 25/289 (8%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHF---AMKILDKQKVVKLKQIEHTLNEKRILQAV 99 QF + LG G FG V + K+ F A+K+L K ++ IE L E ++ Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKML-KADIIASSDIEEFLREAACMKEF 82 Query: 100 NFPFLVKL-EYSFKDNSN-----LYMVMEYVPGGEMFSHL--RRIGR--FSEPHARF--Y 147 + P + KL S + + +++ ++ G++ + L RIG F+ P + Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP---- 203 I EYL S + I+RDL N ++ + + V DFG ++++ + G Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 204 -EYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPS 260 ++LA E + Y D WA GV ++E M G P+ + +IY ++ G +++ P Sbjct: 203 VKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPP 262 Query: 261 HFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFATTDWIAIY 307 ++ DL+ D +R F L+ + +I H +T +Y Sbjct: 263 ECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLY 311 >6DBM-A nrPDB Length = 318 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 66/219 (30%), Positives = 99/219 (45%), Gaps = 24/219 (10%) Query: 31 WENPAQNTA-HLDQFERIKTLGTGSFGRVMLVKHKET----GNHFAMKILDK----QKVV 81 ++ P T H ++I+ LG G FG+V L + T G A+K L Q Sbjct: 19 FQGPGDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRS 78 Query: 82 KLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDN--SNLYMVMEYVPGGEMFSHLRRIGRF 139 KQ E IL+ + ++K + +D ++L +VMEYVP G + +L R Sbjct: 79 GWKQ------EIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPR-HSI 131 Query: 140 SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----- 194 +A QI YLHS I+RDL N+L+D +++ DFG AK V Sbjct: 132 GLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYY 191 Query: 195 RTWTLCGTPEY-LAPEIILSKGYNKAVDWWALGVLIYEM 232 R +P + APE + + A D W+ GV +YE+ Sbjct: 192 RVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYEL 230 >4E93-A nrPDB Length = 377 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 97/220 (44%), Gaps = 14/220 (6%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 +G G+FG V + + A+K + LK L E RIL+ + P +V+L Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLK--AKFLQEARILKQYSHPNIVRLIG 179 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 +Y+VME V GG+ + LR G R EYL S I+RDL Sbjct: 180 VCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDL 239 Query: 169 KPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG----TP-EYLAPEIILSKGYNKAVDWW 223 N L+ ++ ++++DFG ++ + G P ++ APE + Y+ D W Sbjct: 240 AARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVW 299 Query: 224 ALGVLIYEM----AAGYPPFFADQPIQIYEKIVSGKVRFP 259 + G+L++E A+ YP Q + EK G++ P Sbjct: 300 SFGILLWETFSLGASPYPNLSNQQTREFVEK--GGRLPCP 337 >3FME-A nrPDB Length = 290 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 68/260 (26%), Positives = 122/260 (46%), Gaps = 28/260 (10%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL----- 96 D E I LG G++G V ++H +G A+K +++ ++ +KR+L Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVK--------RIRATVNSQEQKRLLMDLDI 58 Query: 97 --QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGG--EMFSHLRRIGR-FSEPHARFYAAQI 151 + V+ PF V + ++++ ME + + + + G+ E A I Sbjct: 59 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 118 Query: 152 VLTFEYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAP 208 V E+LHS L +I+RD+KP N+LI+ G +++ DFG + + G Y+AP Sbjct: 119 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAP 178 Query: 209 EII----LSKGYNKAVDWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIV-SGKVRFPSH- 261 E I KGY+ D W+LG+ + E+A P+ + P Q +++V + P+ Sbjct: 179 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 238 Query: 262 FSSDLKDLLRNLLQVDLTKR 281 FS++ D L+ + +R Sbjct: 239 FSAEFVDFTSQCLKKNSKER 258 >4YFF-A nrPDB Length = 311 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/271 (22%), Positives = 115/271 (42%), Gaps = 11/271 (4%) Query: 2 GNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV 61 G+ + S +K + + L + P+ L + E + +G+GSFG+V Sbjct: 2 GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVY-- 59 Query: 62 KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK-LEYSFKDNSNLYMV 120 K + A+K ++ E IL +N P +++ + D S +V Sbjct: 60 KGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIV 119 Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFY-AAQIVLTFEYLHSLD--LIYRDLKPENLLIDQ 177 +Y+ GG +FS L R + ++ A + EYLH+L +I+RDL N+L+ + Sbjct: 120 TQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYE 179 Query: 178 QGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEM 232 G+ V DFG ++ ++ G ++APE+ Y D ++ + ++E+ Sbjct: 180 DGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEI 239 Query: 233 AAGYPPFFADQPIQIYEKIVSGKVRFPSHFS 263 G PF +P + +R P +S Sbjct: 240 LTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 270 >5FM2-A nrPDB Length = 355 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 71/295 (24%), Positives = 127/295 (43%), Gaps = 58/295 (19%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKL------ 83 KWE P +N KTLG G FG+V+ K T H + VK+ Sbjct: 58 KWEFPRKNLV------LGKTLGEGEFGKVV----KATAFHLKGRAGYTTVAVKMLKENAS 107 Query: 84 -KQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR---RIG-- 137 ++ L+E +L+ VN P ++KL + + L +++EY G + LR ++G Sbjct: 108 PSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPG 167 Query: 138 -----------RFSEPHARF--------YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ 178 P R +A QI +YL + L++RDL N+L+ + Sbjct: 168 YLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEG 227 Query: 179 GYIQVTDFG----------FAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVL 228 ++++DFG + KR +GR +++A E + Y D W+ GVL Sbjct: 228 RKMKISDFGLSRDVYEEDSYVKRSQGRIPV-----KWMAIESLFDHIYTTQSDVWSFGVL 282 Query: 229 IYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 ++E+ G P+ P +++ + +G ++ P + S ++ L+ + + KR Sbjct: 283 LWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 337 >5HIE-A nrPDB Length = 302 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 70/249 (28%), Positives = 115/249 (46%), Gaps = 31/249 (12%) Query: 2 GNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV 61 G+ GSE + + L + D WE P Q + +G+GSFG V Sbjct: 4 GSHHHHHHGSEDRNRMKTLGR--RDSSDDWEIPD------GQITVGQRIGSGSFGTV--Y 53 Query: 62 KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVM 121 K K G+ A+K+L Q++ K L + R + + F + YS K L +V Sbjct: 54 KGKWHGD-VAVKMLTPQQLQAFKNEVGVLRKTRHVNILLF-----MGYSTK--PQLAIVT 105 Query: 122 EYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 ++ G ++ HL I +F A Q +YLH+ +I+RDLK N+ + + Sbjct: 106 QWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLT 165 Query: 181 IQVTDFGFAKRVKGRTWT-------LCGTPEYLAPEIILSKG---YNKAVDWWALGVLIY 230 +++ DFG A VK R W+ L G+ ++APE+I + Y+ D +A G+++Y Sbjct: 166 VKIGDFGLAT-VKSR-WSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLY 223 Query: 231 EMAAGYPPF 239 E+ G P+ Sbjct: 224 ELMTGQLPY 232 >3IO7-A nrPDB Length = 313 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 101/213 (47%), Gaps = 17/213 (7%) Query: 36 QNTAHLDQFER-----IKTLGTGSFGRVMLVKHK----ETGNHFAMKILDKQKVVKLKQI 86 + + ++ QFE ++ LG G+FG V + ++ TG A+K L L+ Sbjct: 17 RGSHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDF 76 Query: 87 EHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHAR 145 E + + LQ N + YS NL ++MEY+P G + +L++ R Sbjct: 77 EREIEILKSLQHDNIVKYKGVCYS-AGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL 135 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPE 204 Y +QI EYL + I+RDL N+L++ + +++ DFG K + + + + P Sbjct: 136 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPG 195 Query: 205 -----YLAPEIILSKGYNKAVDWWALGVLIYEM 232 + APE + ++ A D W+ GV++YE+ Sbjct: 196 ESPIFWYAPESLTESKFSVASDVWSFGVVLYEL 228 >2W1I-A nrPDB Length = 326 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 94/197 (47%), Gaps = 12/197 (6%) Query: 47 IKTLGTGSFGRVMLVKHK----ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ LG G+FG V + ++ TG A+K L L+ E + + LQ N Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIV 105 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHSL 161 + YS NL ++MEY+P G + +L++ R Y +QI EYL + Sbjct: 106 KYKGVCYS-AGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK 164 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPE-----YLAPEIILSKG 215 I+RDL N+L++ + +++ DFG K + + + + P + APE + Sbjct: 165 RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK 224 Query: 216 YNKAVDWWALGVLIYEM 232 ++ A D W+ GV++YE+ Sbjct: 225 FSVASDVWSFGVVLYEL 241 >2H34-A nrPDB Length = 309 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 86/199 (43%), Gaps = 15/199 (7%) Query: 60 LVKHKETGNHFAMKILDKQKVVKLKQIEHTLN-----------EKRILQAVNFPFLVKLE 108 LV G+ + + ++++V LK + TL+ E R + P +V + Sbjct: 41 LVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIH 100 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 + + LY+ M + G ++ + LRR G + P A QI + H+ +RD+ Sbjct: 101 DFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDV 160 Query: 169 KPENLLIDQQGYIQVTDFGFAKRVKGRTWT----LCGTPEYLAPEIILSKGYNKAVDWWA 224 KPEN+L+ + + DFG A T GT Y+APE D +A Sbjct: 161 KPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIYA 220 Query: 225 LGVLIYEMAAGYPPFFADQ 243 L ++YE G PP+ DQ Sbjct: 221 LTCVLYECLTGSPPYQGDQ 239 >3ALO-A nrPDB Length = 327 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 48/201 (23%), Positives = 101/201 (50%), Gaps = 12/201 (5%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 +G G++G V + HK +G A+K + + V + +Q + ++ ++++ + P++V+ Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYG 88 Query: 110 SFKDNSNLYMVMEYVPGG--EMFSHLRRIGRFSEPH---ARFYAAQIVLTFEYLHSLDLI 164 + + ++ ME + + + ++ + P + A + +L +I Sbjct: 89 ALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKII 148 Query: 165 YRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL--CGTPEYLAPEII----LSKGYNK 218 +RD+KP N+L+D+ G I++ DFG + ++ G Y+APE I +GY+ Sbjct: 149 HRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDV 208 Query: 219 AVDWWALGVLIYEMAAGYPPF 239 D W+LG+ +YE+A G P+ Sbjct: 209 RSDVWSLGITLYELATGRFPY 229 >3A4O-X nrPDB Length = 286 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 61/273 (22%), Positives = 114/273 (41%), Gaps = 38/273 (13%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 WE P ++ + +K LG G FG V + + A+K L + ++ L Sbjct: 8 WEIPRES------IKLVKRLGAGQFGEVWM-GYYNNSTKVAVKTLKPGTM----SVQAFL 56 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI--GRFSEPHARFYA 148 E +++ + LV+L +Y++ EY+ G + L+ G+ P ++ Sbjct: 57 EEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFS 116 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY--- 205 AQI Y+ + I+RDL+ N+L+ + ++ DFG A+ ++ +T ++ Sbjct: 117 AQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIK 176 Query: 206 -LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSS 264 APE I + D W+ G+L+YE+ + GK+ +P ++ Sbjct: 177 WTAPEAINFGCFTIKSDVWSFGILLYEI------------------VTYGKIPYPGRTNA 218 Query: 265 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 D++ L Q R N + + DI W Sbjct: 219 ---DVMTALSQGYRMPRVENCPDELYDIMKMCW 248 >5HI2-A nrPDB Length = 283 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 101/202 (50%), Gaps = 25/202 (12%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLE 108 +G+GSFG V K K G+ A+K+L Q++ K NE +L+ + L+ + Sbjct: 28 IGSGSFGTV--YKGKWHGD-VAVKMLTPQQLQAFK------NEVGVLRKTRHVNILLFMG 78 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRD 167 YS K L +V ++ G ++ HL +F A Q +YLH+ +I+RD Sbjct: 79 YSTK--PQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRD 136 Query: 168 LKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-------LCGTPEYLAPEIIL---SKGYN 217 LK N+ + + +++ DFG A VK R W+ L G+ ++APE+I S Y+ Sbjct: 137 LKSNNIFLHEDNTVKIGDFGLAT-VKSR-WSGSHQFEQLSGSILWMAPEVIRMQDSNPYS 194 Query: 218 KAVDWWALGVLIYEMAAGYPPF 239 D +A G+++YE+ G P+ Sbjct: 195 FQSDVYAFGIVLYELMTGQLPY 216 >5L2Q-C nrPDB Length = 320 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 44/153 (28%), Positives = 79/153 (51%), Gaps = 7/153 (4%) Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVKGRT 196 R SE +V E LH ++++RDLK N++++++ + I +T+F K + Sbjct: 149 RLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEG 208 Query: 197 WTL---CGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252 L G+P Y++P+++ + Y K D WALGV+++ M G PF+ P +++ KI Sbjct: 209 DLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIK 268 Query: 253 SGKVRFP--SHFSSDLKDLLRNLLQVDLTKRFG 283 + + P S + L+R LL +D +R Sbjct: 269 AAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLA 301 >4AU8-A nrPDB Length = 296 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 105/206 (50%), Gaps = 13/206 (6%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMK---ILDKQKVVKLKQIEHTLNEKRILQAV 99 ++E+++ +G G++G V K++ET A+K + D + V L E +L+ + Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVP----SSALREICLLKEL 62 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH-ARFYAAQIVLTFEYL 158 +V+L + L +V E+ ++ + +P + + Q++ + Sbjct: 63 KHKNIVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 121 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIIL-SK 214 HS ++++RDLKP+NLLI++ G +++ DFG A+ + R ++ T Y P+++ +K Sbjct: 122 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFF 240 Y+ ++D W+ G + E+A P F Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLF 207 >4OLI-A nrPDB Length = 645 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 99/219 (45%), Gaps = 25/219 (11%) Query: 32 ENPAQNTA--HLDQFERIKTLGTGSFGRVMLVKHKET----GNHFAMKIL----DKQKVV 81 ++PA + H ++I+ LG G FG+V L + T G A+K L Q Sbjct: 341 DSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRS 400 Query: 82 KLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNS--NLYMVMEYVPGGEMFSHLRRIGRF 139 KQ E IL+ + ++K + +D +L +VMEYVP G + +L R Sbjct: 401 GWKQ------EIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPR-HSI 453 Query: 140 SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----- 194 +A QI YLHS I+R+L N+L+D +++ DFG AK V Sbjct: 454 GLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYY 513 Query: 195 RTWTLCGTPEY-LAPEIILSKGYNKAVDWWALGVLIYEM 232 R +P + APE + + A D W+ GV +YE+ Sbjct: 514 RVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYEL 552 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 48/176 (27%), Positives = 73/176 (41%), Gaps = 17/176 (9%) Query: 119 MVMEYVPGGEMFSHLRRIGRFSEPHA--RFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 MV EYV G + LRR R P A A Q+ YL + +L++ ++ N+L+ Sbjct: 143 MVTEYVEHGPLDVWLRR-ERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 201 Query: 177 QQG-------YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK---AVDWWALG 226 + G +I+++D G R + P +LAPE L G N A+D W G Sbjct: 202 RLGLAEGTSPFIKLSDPGVGLGALSREERVERIP-WLAPE-CLPGGANSLSTAMDKWGFG 259 Query: 227 VLIYEMA-AGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + E+ G P + P + E + R P L L L + T+R Sbjct: 260 ATLLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR 314 >4Y83-A nrPDB Length = 332 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/254 (23%), Positives = 109/254 (42%), Gaps = 24/254 (9%) Query: 53 GSFGRVMLVKHKETGNHFAMKILD----KQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 G+FG+V L + +T A K++ K V+++ N + AV + Sbjct: 84 GAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLW------- 136 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 +++ ME GG + L G E + ++ ++LHS +I+ D+ Sbjct: 137 -----GETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDI 191 Query: 169 KPENLLIDQQGYIQVTDFGFAKRVKGRTW---TLCGTPEYLAPEIILSKGYNKAVDWWAL 225 KP N++ + V DFG + ++ + L GT Y++PE+IL +G++ D ++L Sbjct: 192 KPSNIVFMSTKAVLV-DFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSL 250 Query: 226 GVLIYEMAAGYPPFFADQPIQIYEK---IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRF 282 G + M G PP+ P Y I+ + + D +R L++ L +R Sbjct: 251 GATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASL-ERN 309 Query: 283 GNLKNGVNDIKNHK 296 N + D+ H+ Sbjct: 310 PNHRPRAADLLKHE 323 >3PP0-A nrPDB Length = 338 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 98/208 (47%), Gaps = 14/208 (6%) Query: 43 QFERIKTLGTGSFGRVM----LVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 + ++K LG+G+FG V + + A+K+L + K + L+E ++ Sbjct: 18 ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANK--EILDEAYVMAG 75 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEY 157 V P++ +L S + +V + +P G + H+R GR + QI Y Sbjct: 76 VGSPYVSRL-LGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSY 134 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--RVKGRTWTLCG--TP-EYLAPEIIL 212 L + L++RDL N+L+ ++++TDFG A+ + + G P +++A E IL Sbjct: 135 LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL 194 Query: 213 SKGYNKAVDWWALGVLIYE-MAAGYPPF 239 + + D W+ GV ++E M G P+ Sbjct: 195 RRRFTHQSDVWSYGVTVWELMTFGAKPY 222 >4M66-A nrPDB Length = 325 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 111/232 (47%), Gaps = 19/232 (8%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVV-KLKQIEHTLNEKRILQAVN 100 ++ ++++ +G G FG V H+ + A+KI++ +K+ ++K + + NE +L Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLL--- 76 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 L++ F S +V ++ G + L+ P ++VL YLHS Sbjct: 77 LGVTEDLQWDFV--SGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHS 134 Query: 161 LD--LIYRDLKPENLLIDQQGYIQVTDFGFAK---------RVKGRTWTLCGTPEYLAPE 209 LD L++RDLKP N+L+D + + ++ DFG + + GT YL PE Sbjct: 135 LDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPE 194 Query: 210 II--LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP 259 ++ ++ +KA D ++ G+L++ + AG D+ I E + + R P Sbjct: 195 LLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPP 246 >3RAW-A nrPDB Length = 381 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/255 (24%), Positives = 108/255 (42%), Gaps = 45/255 (17%) Query: 42 DQFERIKTLGTGSFGRVM-LVKHKETGNHFAMKILD---------KQKVVKLKQIEHTLN 91 +++E + LG G+FG+V+ + H + A+KI+ + ++ LK+I+ Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDK 110 Query: 92 EKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR--IGRFSEPHARFYAA 149 E + L V + F + ++ + E + G F L+ + PH R A Sbjct: 111 ENKFL-------CVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAY 162 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-------------------IQVTDFGFAK 190 Q+ +LH L + DLKPEN+L + I+V DFG A Sbjct: 163 QLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSAT 222 Query: 191 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD---QPIQI 247 T+ T Y PE+IL G+ + D W++G +++E G+ F + + + Sbjct: 223 FDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVM 282 Query: 248 YEKIVSGKVRFPSHF 262 EKI+ PSH Sbjct: 283 MEKILGP---IPSHM 294 >3CJF-A nrPDB Length = 309 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/269 (24%), Positives = 121/269 (44%), Gaps = 45/269 (16%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVML-----VKHKETGNHFAMKILDK------- 77 KWE P D+ K LG G+FG+V+ + T A+K+L + Sbjct: 21 KWEFPR------DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEH 74 Query: 78 ----QKVVKLKQIEHTLNEKRILQAVN---FPFLVKLEYSFKDNSNLYMVM---EYVPGG 127 ++ L I H LN +L A P +V +E+ N + Y+ E+VP Sbjct: 75 RALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYK 134 Query: 128 EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFG 187 +++ + H Y+ Q+ E+L S I+RDL N+L+ ++ +++ DFG Sbjct: 135 DLYKDF-----LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFG 189 Query: 188 FAKRV-KGRTWTLCGTP----EYLAPEIILSKGYNKAVDWWALGVLIYEM----AAGYPP 238 A+ + K + G +++APE I + Y D W+ GVL++E+ A+ YP Sbjct: 190 LARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPG 249 Query: 239 FFADQPIQIYEKIVSG-KVRFPSHFSSDL 266 D+ + ++ G ++R P + + ++ Sbjct: 250 VKIDE--EFCRRLKEGTRMRAPDYTTPEM 276 >4E20-A nrPDB Length = 290 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 94/205 (45%), Gaps = 15/205 (7%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKET----GNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 H ++I+ LG G FG+V L + T G A+K L + +L+ E I Sbjct: 6 HKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ--REIEI 63 Query: 96 LQAVNFPFLVKLEYSFKDNS--NLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 L+ + +VK + +D ++ +VMEYVP G + +L R +A QI Sbjct: 64 LRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQICE 122 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTPEY-LA 207 YLH+ I+R L N+L+D +++ DFG AK V R +P + A Sbjct: 123 GMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYA 182 Query: 208 PEIILSKGYNKAVDWWALGVLIYEM 232 PE + + A D W+ GV +YE+ Sbjct: 183 PECLKECKFYYASDVWSFGVTLYEL 207 >6DBN-A nrPDB Length = 316 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 61/250 (24%), Positives = 117/250 (46%), Gaps = 36/250 (14%) Query: 44 FERIKTLGTGSFGRVMLVKHK----ETGNHFAMKILDKQK----VVKLKQIEHTLNEKRI 95 +RI+ LG G FG+V L ++ TG A+K L + + LK+ E I Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKK------EIEI 90 Query: 96 LQAVNFPFLVKLE-YSFKDNSN-LYMVMEYVPGGEMFSHL-RRIGRFSEPHARFYAAQIV 152 L+ + +VK + +D N + ++ME++P G + +L + + + YA QI Sbjct: 91 LRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQIC 150 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPE----YL 206 +YL S ++RDL N+L++ + +++ DFG K ++ +T+ + + Sbjct: 151 KGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY 210 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD---QPIQIYEKIVSGKVRFPSHFS 263 APE ++ + A D W+ GV ++E+ + D P+ ++ K++ P+H Sbjct: 211 APECLMQSKFYIASDVWSFGVTLHELLT-----YCDSDSSPMALFLKMIG-----PTHGQ 260 Query: 264 SDLKDLLRNL 273 + L+ L Sbjct: 261 MTVTRLVNTL 270 >2J0K-A nrPDB Length = 656 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 67/264 (25%), Positives = 119/264 (45%), Gaps = 16/264 (6%) Query: 43 QFERI---KTLGTGSFGRVMLVKHKETGN-HFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 Q ERI + +G G FG V + N A+ I + E L E ++ Sbjct: 388 QRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQ 447 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF--YAAQIVLTFE 156 + P +VKL +N ++++ME GE+ S L+ + +FS A YA Q+ Sbjct: 448 FDHPHIVKLIGVITENP-VWIIMELCTLGELRSFLQ-VRKFSLDLASLILYAYQLSTALA 505 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----EYLAPEIIL 212 YL S ++RD+ N+L+ +++ DFG ++ ++ T+ +++APE I Sbjct: 506 YLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESIN 565 Query: 213 SKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 + + A D W GV ++E + G PF + + +I +G ++ P + L L+ Sbjct: 566 FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLM 625 Query: 271 RNLLQVDLTK--RFGNLKNGVNDI 292 D ++ RF LK ++ I Sbjct: 626 TKCWAYDPSRRPRFTELKAQLSTI 649 >2DQ7-X nrPDB Length = 283 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 22/260 (8%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGN-HFAMKILDKQKVVKLKQIEHT 89 WE P ++ + IK LG G FG V + GN A+K L + E Sbjct: 4 WEIPRES------LQLIKRLGNGQFGEVWM--GTWNGNTKVAIKTLKPGTMSP----ESF 51 Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GR-FSEPHARFY 147 L E +I++ + LV+L Y+ +Y+V EY+ G + L+ GR P+ Sbjct: 52 LEEAQIMKKLKHDKLVQL-YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDM 110 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY-- 205 AAQ+ Y+ ++ I+RDL+ N+L+ ++ DFG A+ ++ +T ++ Sbjct: 111 AAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPI 170 Query: 206 --LAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSH 261 APE L + D W+ G+L+ E+ G P+ ++ E++ G ++ P Sbjct: 171 KWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQD 230 Query: 262 FSSDLKDLLRNLLQVDLTKR 281 L +L+ + + D +R Sbjct: 231 CPISLHELMIHCWKKDPEER 250 >2H8H-A nrPDB Length = 535 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/229 (24%), Positives = 104/229 (45%), Gaps = 14/229 (6%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G FG V + T A+K L + E L E ++++ + LV+L Y Sbjct: 275 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQL-Y 328 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSE-PHARFYAAQIVLTFEYLHSLDLIYRD 167 + +Y+V EY+ G + L+ G++ P AAQI Y+ ++ ++RD Sbjct: 329 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 388 Query: 168 LKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY----LAPEIILSKGYNKAVDWW 223 L+ N+L+ + +V DFG A+ ++ +T ++ APE L + D W Sbjct: 389 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 448 Query: 224 ALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 + G+L+ E+ G P+ ++ +++ G ++ P L DL+ Sbjct: 449 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 497 >5SYS-A nrPDB Length = 286 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 58/240 (24%), Positives = 108/240 (45%), Gaps = 14/240 (5%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G FG + T A+K L + E L E ++++ + LV+L Y Sbjct: 26 LGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQL-Y 79 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSE-PHARFYAAQIVLTFEYLHSLDLIYRD 167 + +Y+V EY+ G + L+ +G++ P AAQI Y+ ++ ++RD Sbjct: 80 AVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 139 Query: 168 LKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY----LAPEIILSKGYNKAVDWW 223 L+ N+L+ + +V DFG A+ ++ +T ++ APE L + D W Sbjct: 140 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 199 Query: 224 ALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + G+L+ E+ G P+ ++ +++ G ++ P L DL+ + D +R Sbjct: 200 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEER 259 >4H1J-A nrPDB Length = 293 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 97/202 (48%), Gaps = 12/202 (5%) Query: 48 KTLGTGSFGRV---MLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFL 104 + LG G FG V + HK + A+K K L E ++E I++ ++ P + Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKD--CTLDNKEKFMSEAVIMKNLDHPHI 87 Query: 105 VKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLDL 163 VKL + +++ME P GE+ +L R Y+ QI YL S++ Sbjct: 88 VKL-IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINC 146 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW---TLCGTP-EYLAPEIILSKGYNKA 219 ++RD+ N+L+ +++ DFG ++ ++ + ++ P ++++PE I + + A Sbjct: 147 VHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTA 206 Query: 220 VDWWALGVLIYEMAA-GYPPFF 240 D W V ++E+ + G PFF Sbjct: 207 SDVWMFAVCMWEILSFGKQPFF 228 >4EBW-A nrPDB Length = 304 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 66/264 (25%), Positives = 119/264 (45%), Gaps = 16/264 (6%) Query: 43 QFERI---KTLGTGSFGRVMLVKHKETGN-HFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 Q ERI + +G G FG V + N A+ I + E L E ++ Sbjct: 36 QRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQ 95 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF--YAAQIVLTFE 156 + P +VKL +N ++++ME GE+ S L+ + ++S A YA Q+ Sbjct: 96 FDHPHIVKLIGVITENP-VWIIMELCTLGELRSFLQ-VRKYSLDLASLILYAYQLSTALA 153 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----EYLAPEIIL 212 YL S ++RD+ N+L+ +++ DFG ++ ++ T+ +++APE I Sbjct: 154 YLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESIN 213 Query: 213 SKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 + + A D W GV ++E + G PF + + +I +G ++ P + L L+ Sbjct: 214 FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLM 273 Query: 271 RNLLQVDLTK--RFGNLKNGVNDI 292 D ++ RF LK ++ I Sbjct: 274 TKCWAYDPSRRPRFTELKAQLSTI 297 >5GNK-A nrPDB Length = 297 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 96/214 (44%), Gaps = 26/214 (12%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ--KVVKLKQIEHTLNEKRILQAVN 100 +F++IK LG+G+FG V G + + K+ + K + L+E ++ +V+ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 79 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLH 159 P + +L S + ++M+ +P G + ++R + + QI YL Sbjct: 80 NPHVCRL-LGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE 138 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE-------------YL 206 L++RDL N+L+ ++++TDFG AK L G E ++ Sbjct: 139 DRRLVHRDLAARNVLVKTPQHVKITDFGLAK--------LLGAEEKEYHAEGGKVPIKWM 190 Query: 207 APEIILSKGYNKAVDWWALGVLIYE-MAAGYPPF 239 A E IL + Y D W+ GV ++E M G P+ Sbjct: 191 ALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 224 >2W96-B nrPDB Length = 306 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 109/226 (48%), Gaps = 20/226 (8%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMK---ILDKQKVVKLKQIEHTLNEKRILQAV 99 ++E + +G G++G V + +G+ A+K + + ++ + + + +R L+A Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRR-LEAF 63 Query: 100 NFPFLVKL----EYSFKDNS-NLYMVMEYVPGGEMFSHLRRIGRFSEPHARF--YAAQIV 152 P +V+L S D + +V E+V ++ ++L + P Q + Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPE 209 ++LH+ +++RDLKPEN+L+ G +++ DFG A R+ L T Y APE Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-RIYSYQMALDPVVVTLWYRAPE 181 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQIYEKI 251 ++L Y VD W++G + EM P F ADQ +I++ I Sbjct: 182 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 227 >2Y6O-A nrPDB Length = 291 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 63/253 (24%), Positives = 111/253 (43%), Gaps = 14/253 (5%) Query: 48 KTLGTGSFGRVMLVKHKETGNH-FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 K +G G FG V + K G + I + KQ L+E I+ + P ++ Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIH 79 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 LE + ++ EY+ G + + LR+ GRF+ I +YL + ++ Sbjct: 80 LEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVH 139 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTP---EYLAPEIILSKGYNKA 219 RDL N+L++ +V+DFG ++ ++ +T G + APE I + + A Sbjct: 140 RDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSA 199 Query: 220 VDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSD--LKDLLRNLLQV 276 D W+ G++++E M+ G P++ D Q K + R P L L+ + Q Sbjct: 200 SDVWSYGIVMWEVMSYGERPYW-DMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQK 258 Query: 277 DLTKR--FGNLKN 287 + + R FG + N Sbjct: 259 ERSDRPKFGQIVN 271 >3LZB-A nrPDB Length = 327 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 60/257 (23%), Positives = 111/257 (43%), Gaps = 27/257 (10%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ--KVVKLKQIEHTLNEKRILQAVN 100 +F++IK LG+G+FG V G + + K+ + K + L+E ++ +V+ Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 75 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLH 159 P + +L S + ++ + +P G + ++R + + QI YL Sbjct: 76 NPHVCRL-LGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE 134 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE-------------YL 206 L++RDL N+L+ ++++TDFG AK L G E ++ Sbjct: 135 DRRLVHRDLAARNVLVKTPQHVKITDFGLAK--------LLGAEEKEYHAEGGKVPIKWM 186 Query: 207 APEIILSKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSS 264 A E IL + Y D W+ GV ++E M G P+ +I + G ++ P + Sbjct: 187 ALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTI 246 Query: 265 DLKDLLRNLLQVDLTKR 281 D+ ++R +D R Sbjct: 247 DVYMIMRKCWMIDADSR 263 >6FER-A nrPDB Length = 309 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 60/227 (26%), Positives = 97/227 (42%), Gaps = 39/227 (17%) Query: 50 LGTGSFGRVMLVK----HKETGNHFAMKILDKQKV-VKLKQIEHTLN---------EKRI 95 LG G FG V L + K FA+ + Q V V +K + N E +I Sbjct: 17 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKI 76 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR----------IGRFSEPHAR 145 + + P ++ L + L M+ EY+ G++ L R + S + + Sbjct: 77 MSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLK 136 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--------RVKGRTW 197 F A QI +YL SL+ ++RDL N L+ + I++ DFG ++ R++GR Sbjct: 137 FMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAV 196 Query: 198 TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP 244 +++ E IL + A D WA GV ++E F +QP Sbjct: 197 L---PIRWMSWESILLGKFTTASDVWAFGVTLWETFT----FCQEQP 236 >3RP9-A nrPDB Length = 458 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 102/231 (44%), Gaps = 46/231 (19%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVK----LKQIEHTLNEKRILQ 97 D++E +GTGS+G V E + +++ +K+++ L + L E IL Sbjct: 53 DRYEIRHLIGTGSYGHVC-----EAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILN 107 Query: 98 AVNFPFLVK-----LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 +N +VK + + LY+V+E + + R +E H + ++ Sbjct: 108 RLNHDHVVKVLDIVIPKDVEKFDELYVVLE-IADSDFKKLFRTPVYLTELHIKTLLYNLL 166 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-------------------- 192 + +Y+HS +++RDLKP N L++Q ++V DFG A+ V Sbjct: 167 VGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMN 226 Query: 193 -------KGRTWTLCG---TPEYLAPE-IILSKGYNKAVDWWALGVLIYEM 232 K L G T Y APE I+L + Y +A+D W++G + E+ Sbjct: 227 LVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAEL 277 >6O6Q-A nrPDB Length = 335 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 114/244 (46%), Gaps = 46/244 (18%) Query: 25 EDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLK 84 +D KW NP +N +E ++ LG G + V L E +K+L K VK K Sbjct: 31 DDLNIKW-NPQEN------YEILRKLGRGKYSEVFLGIDLEKREKVVIKVL---KPVKRK 80 Query: 85 QIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYV------PGGEMFSHLRRIG- 137 +I+ ++ IL+ + D N+ +++ V G +F H+ I Sbjct: 81 KIKREIS---ILK------------NLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDF 125 Query: 138 -----RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ-QGYIQVTDFGFAKR 191 F++ RFY +++ +Y HS+ +++RD+KP N++ID + +++ D+G A+ Sbjct: 126 RSLYPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEY 185 Query: 192 VK-GRTWTLCGTPEYL-APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQ 243 G + + Y PE+++ + Y+ ++D W+ G ++ M PFF DQ Sbjct: 186 YHPGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQ 245 Query: 244 PIQI 247 +QI Sbjct: 246 LVQI 249 >1FVR-A nrPDB Length = 327 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 56/249 (22%), Positives = 104/249 (41%), Gaps = 31/249 (12%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKL 107 +G G+FG+V+ + K+ G I ++ E +L + + P ++ L Sbjct: 32 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINL 91 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRR----------------IGRFSEPHARFYAAQI 151 + + LY+ +EY P G + LR+ S +AA + Sbjct: 92 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADV 151 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFG-------FAKRVKGRTWTLCGTPE 204 +YL I+RDL N+L+ + ++ DFG + K+ GR Sbjct: 152 ARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRL-----PVR 206 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHF 262 ++A E + Y D W+ GVL++E+ + G P+ ++YEK+ G ++ P + Sbjct: 207 WMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNC 266 Query: 263 SSDLKDLLR 271 ++ DL+R Sbjct: 267 DDEVYDLMR 275 >3N9X-A nrPDB Length = 432 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/216 (25%), Positives = 101/216 (46%), Gaps = 37/216 (17%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDK--QKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 +G GS+G V L K T + A+K +++ + ++ K+I L E IL + ++++L Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRI---LREITILNRLKSDYIIRL 90 Query: 108 -EYSFKDN----SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 + D+ LY+V+E + ++ + +E H + ++L ++H Sbjct: 91 YDLIIPDDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEEHIKTILYNLLLGENFIHESG 149 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFA-------------------------KRVKGRTW 197 +I+RDLKP N L++Q ++V DFG A K +K + Sbjct: 150 IIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLT 209 Query: 198 TLCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEM 232 + T Y APE+IL + Y K++D W+ G + E+ Sbjct: 210 SHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAEL 245 >3G0E-A nrPDB Length = 336 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 68/287 (23%), Positives = 128/287 (44%), Gaps = 46/287 (16%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVM------LVKHKETGNHFAMKILDKQKVVKL 83 KWE P ++ KTLG G+FG+V+ L+K + A+K+L + L Sbjct: 40 KWEFPR------NRLSFGKTLGAGAFGKVVEATAYGLIK-SDAAMTVAVKML--KPSAHL 90 Query: 84 KQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-----IG 137 + E ++E ++L + N +V L + ++ EY G++ + LRR I Sbjct: 91 TEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFIC 150 Query: 138 RFSEPHARF-------------YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184 + P ++ Q+ +L S + I+RDL N+L+ ++ Sbjct: 151 SKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKIC 210 Query: 185 DFGFAKRVKGRT-WTLCGTP----EYLAPEIILSKGYNKAVDWWALGVLIYEM----AAG 235 DFG A+ +K + + + G +++APE I + Y D W+ G+ ++E+ ++ Sbjct: 211 DFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP 270 Query: 236 YPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 YP D + Y+ I G ++ P H +++ D+++ D KR Sbjct: 271 YPGMPVDS--KFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKR 315 >6F3F-A nrPDB Length = 455 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 104/229 (45%), Gaps = 14/229 (6%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G FG V + T A+K L + E L E ++++ + LV+L Y Sbjct: 195 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQL-Y 248 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSE-PHARFYAAQIVLTFEYLHSLDLIYRD 167 + +Y+V EY+ G + L+ G++ P +AQI Y+ ++ ++RD Sbjct: 249 AVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRD 308 Query: 168 LKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY----LAPEIILSKGYNKAVDWW 223 L+ N+L+ + +V DFG A+ ++ +T ++ APE L + D W Sbjct: 309 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 368 Query: 224 ALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 + G+L+ E+ G P+ ++ +++ G ++ P L DL+ Sbjct: 369 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 417 >3DKO-A nrPDB Length = 318 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/244 (23%), Positives = 108/244 (44%), Gaps = 10/244 (4%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKV-VKLKQIEHTLNEKRILQAVNFPFLVK 106 + +G G FG V + K G + KV KQ L E I+ + P +V Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVH 108 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 LE + +V+E++ G + + LR+ G+F+ I YL + ++ Sbjct: 109 LEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVH 168 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTP---EYLAPEIILSKGYNKA 219 RDL N+L++ +V+DFG ++ ++ +T G + APE I + + A Sbjct: 169 RDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSA 228 Query: 220 VDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVD 277 D W+ G++++E M+ G P++ + + I G ++ P + L L+ + Q + Sbjct: 229 SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKE 288 Query: 278 LTKR 281 +R Sbjct: 289 RAER 292 >5TOS-A nrPDB Length = 395 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 50/158 (31%), Positives = 80/158 (50%), Gaps = 13/158 (8%) Query: 90 LNEKRILQAVNFPFLVKL-EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148 L E L ++ P LVKL Y +D L +V E++ G + +HL R G + +P F Sbjct: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 Query: 149 AQIVLT----FEYLHS--LDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----RVKGRTW 197 + L +LHS + +IYRD+K N+L+D +++DFG A+ + + Sbjct: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 Query: 198 TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAG 235 + GT Y APE + S N D ++ GVL+ E+ +G Sbjct: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 >2PSQ-A nrPDB Length = 370 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 65/275 (23%), Positives = 123/275 (44%), Gaps = 41/275 (14%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLV--------KHKETGNHFAMKILDKQKVV 81 KWE P D+ K LG G FG+V++ K KE A+K+L Sbjct: 75 KWEFPR------DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT-VAVKMLKDDATE 127 Query: 82 KLKQIEHTLNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR----- 135 K + ++E +++ + ++ L + + LY+++EY G + +LR Sbjct: 128 K--DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPG 185 Query: 136 ------IGRFSEPHARF-----YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184 I R E F Q+ EYL S I+RDL N+L+ + +++ Sbjct: 186 MEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIA 245 Query: 185 DFGFAKRVKG----RTWTLCGTP-EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPP 238 DFG A+ + + T P +++APE + + Y D W+ GVL++E+ G P Sbjct: 246 DFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSP 305 Query: 239 FFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRN 272 + ++++ + G ++ P++ +++L ++R+ Sbjct: 306 YPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRD 340 >5EG3-A nrPDB Length = 334 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 67/273 (24%), Positives = 120/273 (43%), Gaps = 37/273 (13%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLV--------KHKETGNHFAMKILDKQKVV 81 KWE P D+ K LG G+FG+V++ K KE A+K+L Sbjct: 29 KWEFPR------DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVT-VAVKMLKDDATE 81 Query: 82 K-----------LKQIEHTLNEKRILQAV--NFPFLVKLEYSFKDNSNLYMVMEYVPGGE 128 K +K I N +L A + P V + Y+ K N Y+ PG E Sbjct: 82 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGME 141 Query: 129 MFSHLRRIGRFSEPHARFYAA--QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF 186 + + R+ + Q+ EYL S I+RDL N+L+ + +++ DF Sbjct: 142 LSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 201 Query: 187 GFAKRVKG----RTWTLCGTP-EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFF 240 G A+ + + T P +++APE + + Y D W+ GVL++E+ G P+ Sbjct: 202 GLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 261 Query: 241 ADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRN 272 ++++ + G ++ P++ +++L ++R+ Sbjct: 262 GIPVEELFKLLKEGHRMDKPANCTNELYMMMRD 294 >4PDO-A nrPDB Length = 299 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 62/268 (23%), Positives = 115/268 (42%), Gaps = 17/268 (6%) Query: 31 WENPAQ------NTAHLDQFERIKTLGTGSFGRVM--LVKHKETGNHFAMKILDKQKVVK 82 +E+P Q H R K +G G FG V ++K + I + Sbjct: 17 YEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYT 76 Query: 83 LKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSE 141 KQ L E I+ + +++LE + ++ EY+ G + LR + G FS Sbjct: 77 EKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSV 136 Query: 142 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWT 198 I +YL +++ ++RDL N+L++ +V+DFG ++ ++ T+T Sbjct: 137 LQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYT 196 Query: 199 LCGTP---EYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG 254 G + APE I + + A D W+ G++++E M G P++ ++ + I G Sbjct: 197 TSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDG 256 Query: 255 -KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 ++ P S + L+ Q + +R Sbjct: 257 FRLPTPMDCPSAIYQLMMQCWQQERARR 284 >1JPA-A nrPDB Length = 312 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 64/260 (24%), Positives = 115/260 (44%), Gaps = 20/260 (7%) Query: 48 KTLGTGSFGRVMLVKHKETGNH---FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFL 104 + +G G FG V K G A+K L + KQ L+E I+ + P + Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTL--KSGYTEKQRRDFLSEASIMGQFDHPNV 96 Query: 105 VKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLDL 163 + LE ++ + ++ E++ G + S LR+ G+F+ I +YL ++ Sbjct: 97 IHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNY 156 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP--------EYLAPEIILSKG 215 ++RDL N+L++ +V+DFG ++ ++ T T + APE I + Sbjct: 157 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRK 216 Query: 216 YNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS--SDLKDLLRN 272 + A D W+ G++++E M+ G P++ D Q + R P S L L+ + Sbjct: 217 FTSASDVWSYGIVMWEVMSYGERPYW-DMTNQDVINAIEQDYRLPPPMDCPSALHQLMLD 275 Query: 273 LLQVDLTKR--FGNLKNGVN 290 Q D R FG + N ++ Sbjct: 276 CWQKDRNHRPKFGQIVNTLD 295 >6GQK-A nrPDB Length = 328 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 70/297 (23%), Positives = 130/297 (43%), Gaps = 45/297 (15%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVM------LVKHKETGNHFAMKILDKQKVVKL 83 KWE P ++ KTLG G+FG+V+ L+K + A+K+L + Sbjct: 35 KWEFPR------NRLSFGKTLGAGAFGKVVEATAQGLIK-SDAAMTVAVKML--KPSAHS 85 Query: 84 KQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP 142 + E ++E ++L + N +V L + ++ EY G++ + LRR P Sbjct: 86 TEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVP 145 Query: 143 ----------------HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF 186 H ++ Q+ +L S + I+RDL N+L+ ++ DF Sbjct: 146 YKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDF 205 Query: 187 GFAKRVKGRT-WTLCGTP----EYLAPEIILSKGYNKAVDWWALGVLIYEM----AAGYP 237 G A+ +K + + G +++APE I + Y D W+ G+ ++E+ ++ YP Sbjct: 206 GLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYP 265 Query: 238 PFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIK 293 D + Y+ I G ++ P + +++ D+++ D KR K V DI+ Sbjct: 266 GMPVDS--KFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKR-PTFKQIVQDIE 319 >3GC0-A nrPDB Length = 329 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 107/231 (46%), Gaps = 21/231 (9%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH-----T 89 A + +D++ RI LG G++G V T A+K ++L+ E Sbjct: 27 APSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIK------RIRLEHEEEGVPGTA 80 Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149 + E +L+ + +++L+ N L+++ EY ++ ++ + S + + Sbjct: 81 IREVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLY 139 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLI-----DQQGYIQVTDFGFAKR--VKGRTWTL-CG 201 Q++ + HS ++RDLKP+NLL+ + +++ DFG A+ + R +T Sbjct: 140 QLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEII 199 Query: 202 TPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 251 T Y PEI+L S+ Y+ +VD W++ + EM P F D I KI Sbjct: 200 TLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKI 250 >4XCU-A nrPDB Length = 300 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 68/280 (24%), Positives = 118/280 (42%), Gaps = 44/280 (15%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 WE P D+ K LG G FG+V V+ + G A D+ V +K ++ Sbjct: 12 WEFPR------DRLVLGKPLGEGCFGQV--VRAEAFGMDPARP--DQASTVAVKMLKDNA 61 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNL----------YMVMEYVPGGEMFSHLR------ 134 ++K + V+ ++KL K+ NL Y+++E G + LR Sbjct: 62 SDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPG 121 Query: 135 -RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV- 192 G S P A Q+ +YL S I+RDL N+L+ + +++ DFG A+ V Sbjct: 122 SSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH 181 Query: 193 ---------KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFAD 242 GR +++APE + + Y D W+ G+L++E+ G P+ Sbjct: 182 HIDYYKKTSNGRLPV-----KWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI 236 Query: 243 QPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 +++ + G ++ P H +L L+R ++R Sbjct: 237 PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQR 276 >1U54-B nrPDB Length = 291 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 61/242 (25%), Positives = 99/242 (40%), Gaps = 15/242 (6%) Query: 32 ENPAQNTAHL---DQFERIKTLGTGSFGRVMLVKHKETGN---HFAMKILDKQKVVKLKQ 85 E P Q+ L ++ LG GSFG V + A+K L + + + Sbjct: 5 EGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEA 64 Query: 86 IEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHA 144 ++ + E + +++ L++L Y + MV E P G + LR+ G F Sbjct: 65 MDDFIREVNAMHSLDHRNLIRL-YGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTL 123 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE 204 YA Q+ YL S I+RDL NLL+ + +++ DFG + + Sbjct: 124 SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEH 183 Query: 205 ------YLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKVR 257 + APE + ++ ++ A D W GV ++EM G P+ QI KI R Sbjct: 184 RKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGER 243 Query: 258 FP 259 P Sbjct: 244 LP 245 >3MIA-A nrPDB Length = 351 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 50/225 (22%), Positives = 102/225 (45%), Gaps = 41/225 (18%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK--------------ILDKQKVVKLKQI 86 + ++E++ +G G+FG V +H++TG A+K L + K+++L + Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 Query: 87 EHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPG--GEMFSHLRRIGRFSEPHA 144 E+ +N I + P+ + ++Y+V ++ + S++ + +F+ Sbjct: 76 ENVVNLIEICRTKASPY-------NRCKGSIYLVFDFCEHDLAGLLSNV--LVKFTLSEI 126 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----------RVK 193 + ++ Y+H +++RD+K N+LI + G +++ DFG A+ R Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 Query: 194 GRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYP 237 R TL Y PE++L + Y +D W G ++ EM P Sbjct: 187 NRVVTLW----YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 >1U59-A nrPDB Length = 287 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 62/242 (25%), Positives = 113/242 (46%), Gaps = 28/242 (11%) Query: 50 LGTGSFGRVM--LVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 LG G+FG V + + ++ A+K+L KQ K E + E +I+ ++ P++V+L Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 75 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA---QIVLTFEYLHSLDLI 164 L +VME GG + L +G+ E A Q+ + +YL + + Sbjct: 76 -IGVCQAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 165 YRDLKPENLLIDQQGYIQVTDFGFAK-----------RVKGRTWTLCGTPEYLAPEIILS 213 +RDL N+L+ + Y +++DFG +K R G+ W L ++ APE I Sbjct: 133 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPL----KWYAPECINF 187 Query: 214 KGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGK-VRFPSHFSSDLKDLLR 271 + ++ D W+ GV ++E ++ G P+ + ++ I GK + P +L L+ Sbjct: 188 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 247 Query: 272 NL 273 + Sbjct: 248 DC 249 >4HZS-A nrPDB Length = 341 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 57/224 (25%), Positives = 94/224 (41%), Gaps = 12/224 (5%) Query: 47 IKTLGTGSFGRVMLVKHKETGN---HFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 ++ LG GSFG V + A+K L + + + ++ + E + +++ Sbjct: 17 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 76 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLD 162 L++L Y + MV E P G + LR+ G F YA Q+ YL S Sbjct: 77 LIRL-YGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKR 135 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE------YLAPEIILSKGY 216 I+RDL NLL+ + +++ DFG + + + APE + ++ + Sbjct: 136 FIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTF 195 Query: 217 NKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKVRFP 259 + A D W GV ++EM G P+ QI KI R P Sbjct: 196 SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLP 239 >5X02-A nrPDB Length = 347 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 68/296 (22%), Positives = 134/296 (45%), Gaps = 45/296 (15%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH---KETGNHFAMKILDKQKVVKLKQI 86 KWE P +N E K LG+G+FG+VM +TG + + ++ + Sbjct: 42 KWEFPREN------LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER 95 Query: 87 EHTLNE-KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHA 144 E ++E K + Q + +V L + + +Y++ EY G++ ++LR + +FSE Sbjct: 96 EALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEI 155 Query: 145 RF----------------------YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQ 182 + +A Q+ E+L ++RDL N+L+ ++ Sbjct: 156 EYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVK 215 Query: 183 VTDFGFAKRVKGRT-WTLCGTP----EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGY 236 + DFG A+ + + + + G +++APE + Y D W+ G+L++E+ + G Sbjct: 216 ICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGV 275 Query: 237 PPFFADQPI--QIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKN 287 P + P+ Y+ I +G K+ P + + ++ ++++ D KR F NL + Sbjct: 276 NP-YPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTS 330 >3GQL-A nrPDB Length = 326 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 72/282 (25%), Positives = 125/282 (44%), Gaps = 37/282 (13%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVK----HKETGNHF---AMKILDKQKVVK 82 +WE P D+ K LG G+FG+V+L + K+ N A+K+L K Sbjct: 22 RWELPR------DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 75 Query: 83 -----------LKQIEHTLNEKRILQAV--NFPFLVKLEYSFKDNSNLYMVMEYVPGGEM 129 +K I N +L A + P V +EY+ K N Y+ PG E Sbjct: 76 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEY 135 Query: 130 F---SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF 186 SH + S A Q+ EYL S I+RDL N+L+ + +++ DF Sbjct: 136 CYNPSH-NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 194 Query: 187 GFAKRVKGRTW---TLCG--TPEYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFF 240 G A+ + + T G +++APE + + Y D W+ GVL++E+ G P+ Sbjct: 195 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 254 Query: 241 ADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 ++++ + G ++ PS+ +++L ++R+ ++R Sbjct: 255 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR 296 >6CTH-A nrPDB Length = 309 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 53/194 (27%), Positives = 94/194 (48%), Gaps = 11/194 (5%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G FG V +++ + A+K + + +K+ +E +I+ + LVKL Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYA---SEVKIISRLRHKNLVKLIG 79 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ-IVLTFEYLHSLD---LIY 165 + L +V E++ G + SH+ + R+ + + YLH +++ Sbjct: 80 WCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCVLH 139 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTL-CGTPEYLAPEIILSKGYNKAVD 221 RD+K N+++D ++ DFG A+ V KG TL GT Y+APE + S +K D Sbjct: 140 RDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKASKESD 199 Query: 222 WWALGVLIYEMAAG 235 ++ GV+ E+A+G Sbjct: 200 VYSFGVVALEIASG 213 >3NIE-A nrPDB Length = 429 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 53/231 (22%), Positives = 99/231 (42%), Gaps = 48/231 (20%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D +E +G GS+G V L K + A+K +++ E ++ KRIL+ + Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRM-------FEDLIDCKRILREITI 80 Query: 102 PFLVKLEYSFKDNS-----------NLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 +K +Y + + LY+V+E + ++ + +E H + Sbjct: 81 LNRLKSDYIIRLHDLIIPEDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEQHVKTILYN 139 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA--------------------- 189 ++L +++H +I+RDLKP N L++Q +++ DFG A Sbjct: 140 LLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEEN 199 Query: 190 -------KRVKGRTWTLCGTPEYLAPE-IILSKGYNKAVDWWALGVLIYEM 232 K +K + + T Y APE I+L + Y ++D W+ G + E+ Sbjct: 200 EEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAEL 250 >4XUF-A nrPDB Length = 297 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 68/296 (22%), Positives = 134/296 (45%), Gaps = 45/296 (15%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH---KETGNHFAMKILDKQKVVKLKQI 86 KWE P +N E K LG+G+FG+VM +TG + + ++ + Sbjct: 3 KWEFPREN------LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER 56 Query: 87 EHTLNE-KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHA 144 E ++E K + Q + +V L + + +Y++ EY G++ ++LR + +FSE Sbjct: 57 EALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEI 116 Query: 145 RF----------------------YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQ 182 + +A Q+ E+L ++RDL N+L+ ++ Sbjct: 117 EYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVK 176 Query: 183 VTDFGFAKRVKGRT-WTLCGTP----EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGY 236 + DFG A+ + + + + G +++APE + Y D W+ G+L++E+ + G Sbjct: 177 ICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGV 236 Query: 237 PPFFADQPI--QIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKN 287 P + P+ Y+ I +G K+ P + + ++ ++++ D KR F NL + Sbjct: 237 NP-YPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTS 291 >3OMV-A nrPDB Length = 307 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 61/204 (29%), Positives = 104/204 (50%), Gaps = 24/204 (11%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVV--KLKQIEHTLNEKRILQAV-NFPFLVK 106 +G+GSFG V K K G+ A+KIL KVV +Q + NE +L+ + L+ Sbjct: 44 IGSGSFGTVY--KGKWHGD-VAVKIL---KVVDPTPEQFQAFRNEVAVLRKTRHVNILLF 97 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 + Y KDN L +V ++ G ++ HL + +F A Q +YLH+ ++I+ Sbjct: 98 MGYMTKDN--LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIH 155 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-------LCGTPEYLAPEIILSKGYNK 218 RD+K N+ + + +++ DFG A VK R W+ G+ ++APE+I + N Sbjct: 156 RDMKSNNIFLHEGLTVKIGDFGLAT-VKSR-WSGSQQVEQPTGSVLWMAPEVIRMQDNNP 213 Query: 219 ---AVDWWALGVLIYEMAAGYPPF 239 D ++ G+++YE+ G P+ Sbjct: 214 FSFQSDVYSYGIVLYELMTGELPY 237 >5A46-A nrPDB Length = 386 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 75/289 (25%), Positives = 121/289 (41%), Gaps = 51/289 (17%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVK----HKETGNHF---AMKILDKQKVVK 82 +WE P D+ K LG G FG+V+L + K+ N A+K+L K Sbjct: 34 RWELPR------DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 87 Query: 83 -----------LKQIEHTLNEKRILQAV--NFPFLVKLEYSFKDNSNLYMVMEYVPGGEM 129 +K I N +L A + P V +EY+ K N Y+ PG E Sbjct: 88 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEY 147 Query: 130 F---SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF 186 SH + S A Q+ EYL S I+RDL N+L+ + +++ DF Sbjct: 148 CYNPSH-NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 206 Query: 187 GFA----------KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM--AA 234 G A K GR +++APE + + Y D W+ GVL++E+ Sbjct: 207 GLARDIHHIDYYKKTTNGRLPV-----KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLG 261 Query: 235 GYPPFFADQPIQIYEKIVSGKVRF--PSHFSSDLKDLLRNLLQVDLTKR 281 G P + P++ K++ R PS+ +++L ++R+ ++R Sbjct: 262 GSP--YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR 308 >4P5Q-A nrPDB Length = 361 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/250 (23%), Positives = 111/250 (44%), Gaps = 22/250 (8%) Query: 48 KTLGTGSFGRVMLVKHK-ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 K +G G FG V + K + ++ I + KQ L E I+ + P +++ Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIR 98 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF-------EYLH 159 LE + + +V EY+ G + S LR+ A+F Q+V +YL Sbjct: 99 LEGVVTKSKPVMIVTEYMENGSLDSFLRK------HDAQFTVIQLVGMLRGIASGMKYLS 152 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTP---EYLAPEIILS 213 + ++RDL N+LI+ +V+DFG ++ ++ +T G + +PE I Sbjct: 153 DMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAY 212 Query: 214 KGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLR 271 + + A D W+ G++++E M+ G P++ + + + G ++ P + L L+ Sbjct: 213 RKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLML 272 Query: 272 NLLQVDLTKR 281 + Q D R Sbjct: 273 DCWQKDRNNR 282 >2JD5-A nrPDB Length = 373 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 92/208 (44%), Gaps = 19/208 (9%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVK---------LKQIEHTLNEKRILQ 97 ++ LG G F V L K H AMKI+ KV L+++ N K Sbjct: 24 VRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSM 83 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEY-VPGGEMFSHLRRIGRFSEP--HARFYAAQIVLT 154 N + ++ K + +++VM + V G + + +++ P + + + Q++L Sbjct: 84 GANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLG 143 Query: 155 FEYLHS-LDLIYRDLKPENLLID------QQGYIQVTDFGFAKRVKGRTWTLCGTPEYLA 207 +Y+H +I+ D+KPEN+L++ I++ D G A T EY + Sbjct: 144 LDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQTREYRS 203 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAG 235 PE++L + D W+ LI+E+ G Sbjct: 204 PEVLLGAPWGCGADIWSTACLIFELITG 231 >4IAN-A nrPDB Length = 358 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 31/94 (32%), Positives = 54/94 (57%), Gaps = 2/94 (2%) Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI-QVTDFGFAKRVKGRTWT-LCG 201 R Y+ Q+ L + L ++++ D+KP+N+L+++ I ++ DFG A V T Sbjct: 137 VRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLV 196 Query: 202 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAG 235 + Y APEII+ K Y+ +D W++G +YE+ G Sbjct: 197 SRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTG 230 >3BBT-B nrPDB Length = 328 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 106/221 (47%), Gaps = 19/221 (8%) Query: 35 AQNTAHL-----DQFERIKTLGTGSFGRV---MLVKHKETGN-HFAMKILDKQKVVKLKQ 85 A N A L + +R+K LG+G+FG V + V ET A+KIL++ K Sbjct: 3 APNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPK-AN 61 Query: 86 IEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHA 144 +E ++E I+ +++ P LV+L + + +V + +P G + ++ Sbjct: 62 VEF-MDEALIMASMDHPHLVRL-LGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLL 119 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGT 202 + QI YL L++RDL N+L+ ++++TDFG A+ ++G + + G Sbjct: 120 LNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGG 179 Query: 203 P---EYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPF 239 +++A E I + + D W+ GV I+E M G P+ Sbjct: 180 KMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY 220 >3TT0-A nrPDB Length = 382 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 72/282 (25%), Positives = 125/282 (44%), Gaps = 37/282 (13%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVK----HKETGNHF---AMKILDKQKVVK 82 +WE P D+ K LG G+FG+V+L + K+ N A+K+L K Sbjct: 63 RWELPR------DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 116 Query: 83 -----------LKQIEHTLNEKRILQAV--NFPFLVKLEYSFKDNSNLYMVMEYVPGGEM 129 +K I N +L A + P V +EY+ K N Y+ PG E Sbjct: 117 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEY 176 Query: 130 F---SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF 186 SH + S A Q+ EYL S I+RDL N+L+ + +++ DF Sbjct: 177 SYNPSH-NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 235 Query: 187 GFAKRVKGRTW---TLCG--TPEYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFF 240 G A+ + + T G +++APE + + Y D W+ GVL++E+ G P+ Sbjct: 236 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 295 Query: 241 ADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 ++++ + G ++ PS+ +++L ++R+ ++R Sbjct: 296 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR 337 >3BEA-A nrPDB Length = 333 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 109/248 (43%), Gaps = 36/248 (14%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ 78 F+ + + +KWE P N QF KTLG G+FG+V+ G A+ K Sbjct: 29 FIDPTQLPYNEKWEFPRNNL----QFG--KTLGAGAFGKVVEATAFGLGKEDAVL---KV 79 Query: 79 KVVKLKQIEHT------LNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 V LK H ++E +I+ + +V L + + ++ EY G++ + Sbjct: 80 AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLN 139 Query: 132 HLRRIGRFSEPHARF--------------YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ 177 LRR R E F +++Q+ +L S + I+RD+ N+L+ Sbjct: 140 FLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN 199 Query: 178 QGYIQVTDFGFAKRVKGRT-WTLCGTP----EYLAPEIILSKGYNKAVDWWALGVLIYEM 232 ++ DFG A+ + + + + G +++APE I Y D W+ G+L++E+ Sbjct: 200 GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEI 259 Query: 233 -AAGYPPF 239 + G P+ Sbjct: 260 FSLGLNPY 267 >5L6P-A nrPDB Length = 298 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/258 (24%), Positives = 115/258 (44%), Gaps = 15/258 (5%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKV-VKLKQIEHTLNEKRILQAVNFPFLVK 106 + +G G FG V + K+ G + KV +Q L+E I+ + P +++ Sbjct: 25 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIR 84 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 LE + + ++ E++ + S LR G+F+ I +YL ++ ++ Sbjct: 85 LEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVH 144 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKGR------TWTLCG-TP-EYLAPEIILSKGYN 217 RDL N+L++ +V+DFG ++ ++ T +L G P + APE I + + Sbjct: 145 RDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFT 204 Query: 218 KAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 A D W+ G++++E M+ G P++ D Q V R P D L L+ + Sbjct: 205 SASDVWSYGIVMWEVMSYGERPYW-DMSNQDVINAVEQDYRLPPPM--DCPTALHQLM-L 260 Query: 277 DLTKRFGNLKNGVNDIKN 294 D R NL+ + I N Sbjct: 261 DCWVRDRNLRPKFSQIVN 278 >3ZBF-A nrPDB Length = 322 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 111/247 (44%), Gaps = 29/247 (11%) Query: 50 LGTGSFGRV---MLVKHKETGN---HFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 LG+G+FG V V G+ A+K L K + ++IE L E ++ N P Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQ-EKIEF-LKEAHLMSKFNHPN 98 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARFY-----AAQIVLTFE 156 ++K N Y+++E + GG++ ++LR R+ F P I Sbjct: 99 ILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCV 158 Query: 157 YLHSLDLIYRDLKPENLLIDQQGY-----IQVTDFGFAKRV------KGRTWTLCGTPEY 205 YL + I+RDL N L+ + Y +++ DFG A+ + + R L + Sbjct: 159 YLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPV-RW 217 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKI-VSGKVRFPSHFS 263 +APE ++ + D W+ G+LI+E + G+ P+ A + + + G++ P + Sbjct: 218 MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCP 277 Query: 264 SDLKDLL 270 DL +L+ Sbjct: 278 DDLWNLM 284 >3PLS-A nrPDB Length = 298 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/228 (22%), Positives = 101/228 (44%), Gaps = 22/228 (9%) Query: 48 KTLGTGSFGRVMLVKHKE----TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + +G G FG +V H E N I ++ +++Q+E L E +++ +N P Sbjct: 27 RVIGKGHFG---VVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPN 83 Query: 104 LVKLEYSFKDNSNL-YMVMEYVPGGEMFSHLRRIGRFSEPHAR---FYAAQIVLTFEYLH 159 ++ L L ++++ Y+ G++ +R R P + + Q+ EYL Sbjct: 84 VLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQR--NPTVKDLISFGLQVARGMEYLA 141 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG-------TPEYLAPEIIL 212 ++RDL N ++D+ ++V DFG A+ + R + ++ A E + Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQ 201 Query: 213 SKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGKVRFP 259 + + D W+ GVL++E+ G PP+ P + + G+ R P Sbjct: 202 TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGR-RLP 248 >2OZO-A nrPDB Length = 613 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 67/278 (24%), Positives = 123/278 (44%), Gaps = 47/278 (16%) Query: 50 LGTGSFGRVM--LVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 LG G+FG V + + ++ A+K+L KQ K E + E +I+ ++ P++V+L Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 401 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA---QIVLTFEYLHSLDLI 164 L +VME GG + L +G+ E A Q+ + +YL + + Sbjct: 402 -IGVCQAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Query: 165 YRDLKPENLLIDQQGYIQVTDFGFAK-----------RVKGRTWTLCGTPEYLAPEIILS 213 +R+L N+L+ + Y +++DFG +K R G+ W L ++ APE I Sbjct: 459 HRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPL----KWYAPECINF 513 Query: 214 KGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGK-VRFPSHFSSDLKDLLR 271 + ++ D W+ GV ++E ++ G P+ + ++ I GK + P +L L+ Sbjct: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM- 572 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQR 309 +D +KW D++ + QR Sbjct: 573 ------------------SDCWIYKWEDRPDFLTVEQR 592 >4M7I-A nrPDB Length = 299 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/256 (24%), Positives = 110/256 (42%), Gaps = 40/256 (15%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK--ILDKQKVVKLKQIEHTLNEKRILQ 97 +L FE I+ LG G FG V K+K ++A+K L +++ + E + E + L Sbjct: 3 YLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAR----EKVMREVKALA 58 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI----------GRFS-EPHARF 146 + P +V+ ++ + + + P ++ ++ GR + E R Sbjct: 59 KLEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERS 118 Query: 147 YAAQIVL----TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--------- 193 I L E+LHS L++RDLKP N+ ++V DFG + Sbjct: 119 VCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVL 178 Query: 194 ------GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 R GT Y++PE I Y+ VD ++LG++++E+ YP F+ Q ++ Sbjct: 179 TPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL--YP--FSTQMERV 234 Query: 248 YEKIVSGKVRFPSHFS 263 ++FP F+ Sbjct: 235 RTLTDVRNLKFPPLFT 250 >2CMW-A nrPDB Length = 310 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 78/297 (26%), Positives = 127/297 (42%), Gaps = 38/297 (12%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 K +G G+FG + L K+ T + A+K+ + +E+ ++ P + Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYF 65 Query: 108 EYSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 K N+ MV+E + P E +F R F+ A Q++ EY+HS +LIY Sbjct: 66 GPCGKYNA---MVLELLGPSLEDLFDLCDRT--FTLKTVLMIAIQLLSRMEYVHSKNLIY 120 Query: 166 RDLKPENLLIDQQG-----YIQVTDFGFAKR-VKGRT---------WTLCGTPEYLAPEI 210 RD+KPEN LI +QG I + DFG AK + T +L GT Y++ Sbjct: 121 RDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINT 180 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFP-----SHF 262 L K ++ D ALG + G P AD + Y+KI K P +F Sbjct: 181 HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENF 240 Query: 263 SSDLKDLLRNLLQVDLTKR--FGNLKNGVNDI---KNHKWFATTDWIAIYQRKVEAP 314 ++ LR + ++D ++ + L+ D+ K + + DW+ R + P Sbjct: 241 PEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVG---RPIPTP 294 >2HK5-A nrPDB Length = 270 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 49/210 (23%), Positives = 95/210 (45%), Gaps = 13/210 (6%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 K WE A + + K LG G FG V + + + A+K + + +E Sbjct: 3 KPWEKDAWEIPR-ESLKLEKKLGAGQFGEVWMATYNKH-TKVAVKTMKPGSM----SVEA 56 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF-- 146 L E +++ + LVKL ++ +Y++ E++ G + L+ +P + Sbjct: 57 FLAEANVMKTLQHDKLVKL-HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 115 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTP 203 ++AQI ++ + I+RDL+ N+L+ ++ DFG A+ ++ +T P Sbjct: 116 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP 175 Query: 204 -EYLAPEIILSKGYNKAVDWWALGVLIYEM 232 ++ APE I + D W+ G+L+ E+ Sbjct: 176 IKWTAPEAINFGSFTIKSDVWSFGILLMEI 205 >2VWV-A nrPDB Length = 302 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 111/249 (44%), Gaps = 18/249 (7%) Query: 48 KTLGTGSFGRVMLVKHKETG---NHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFL 104 + +G G FG V + K G + A+K L + +Q L+E I+ P + Sbjct: 22 EVIGAGEFGEVCRGRLKAPGKKESCVAIKTL--KGGYTERQRREFLSEASIMGQFEHPNI 79 Query: 105 VKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 ++LE ++ + ++ E++ G + S LR G+F+ I YL + Sbjct: 80 IRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSY 139 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVK------GRTWTLCG-TP-EYLAPEIILSKG 215 ++RDL N+L++ +V+DFG ++ ++ T +L G P + APE I + Sbjct: 140 VHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAFRK 199 Query: 216 YNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGKVRF--PSHFSSDLKDLLRN 272 + A D W+ G++++E M+ G P++ D Q + R P + L L+ + Sbjct: 200 FTSASDAWSYGIVMWEVMSFGERPYW-DMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLD 258 Query: 273 LLQVDLTKR 281 Q D R Sbjct: 259 CWQKDRNAR 267 >2R2P-A nrPDB Length = 295 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 100/222 (45%), Gaps = 10/222 (4%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKV-VKLKQIEHTLNEKRILQAVNFPFLVK 106 + +G G FG V + K G + KV KQ L E I+ + P ++ Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIH 87 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 LE + + +V EY+ G + + L++ G+F+ I +YL + ++ Sbjct: 88 LEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVH 147 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTP---EYLAPEIILSKGYNKA 219 RDL N+LI+ +V+DFG ++ ++ +T G + APE I + + A Sbjct: 148 RDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSA 207 Query: 220 VDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGKVRFPS 260 D W+ G++++E+ + G P++ + Q K V R PS Sbjct: 208 SDVWSYGIVMWEVVSYGERPYW-EMTNQDVIKAVEEGYRLPS 248 >4NEU-A nrPDB Length = 333 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 94/210 (44%), Gaps = 24/210 (11%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 L +G FG+V L H+ G MK + K ++ E L E +++ + +VKL Sbjct: 32 LDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNC-IEHNEALLEEAKMMNRLRHSRVVKLLG 89 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA--RFYAAQIVLTFEYLHSLDLIYRD 167 + +VMEY+ G + L+ S P + +I+ YLH +I++D Sbjct: 90 VIIEEGKYSLVMEYMEKGNLMHVLK--AEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKD 147 Query: 168 LKPENLLIDQQGYIQVTDFGFA----------------KRVKGRTWTLCGTPEYLAPEII 211 LKPEN+L+D +I++ D G A + V G GT Y+APE + Sbjct: 148 LKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHL 207 Query: 212 --LSKGYNKAVDWWALGVLIYEMAAGYPPF 239 ++ + D ++ V+++ + A P+ Sbjct: 208 NDVNAKPTEKSDVYSFAVVLWAIFANKEPY 237 >2PZI-A nrPDB Length = 681 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 44/151 (29%), Positives = 80/151 (52%), Gaps = 12/151 (7%) Query: 93 KRILQAVNFPFLVKLEYSFKDNSNL------YMVMEYVPGGEMFSHLRRIGRFSEPHARF 146 ++ L V P +V++ ++F ++++ Y+VMEYV GG+ + + A Sbjct: 130 RQFLAEVVHPSIVQI-FNFVEHTDRHGDPVGYIVMEYV-GGQSLKR-SKGQKLPVAEAIA 186 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYL 206 Y +I+ YLHS+ L+Y DLKPEN+++ ++ +++ D G R+ + L GTP + Sbjct: 187 YLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY-LYGTPGFQ 244 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYP 237 APEI+ + G A D + +G + + P Sbjct: 245 APEIVRT-GPTVATDIYTVGRTLAALTLDLP 274 >4K33-A nrPDB Length = 325 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 67/288 (23%), Positives = 124/288 (43%), Gaps = 38/288 (13%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 K LG G+FG+V++ + A K + V +K ++ +K + V+ ++K+ Sbjct: 42 KPLGEGAFGQVVMAEAIGIDKDRAAKPV----TVAVKMLKDDATDKDLSDLVSEMEMMKM 97 Query: 108 EYSFKDNSNL----------YMVMEYVPGGEMFSHLRR-----------IGRFSEPHARF 146 K+ NL Y+++EY G + LR + E F Sbjct: 98 IGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTF 157 Query: 147 -----YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW---T 198 A Q+ EYL S I+RDL N+L+ + +++ DFG A+ V + T Sbjct: 158 KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKET 217 Query: 199 LCG--TPEYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSG- 254 G +++APE + + Y D W+ GVL++E+ G P+ ++++ + G Sbjct: 218 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH 277 Query: 255 KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 ++ P++ + DL ++R ++R K V D+ +TD Sbjct: 278 RMDKPANCTHDLYMIMRECWHAAPSQR-PTFKQLVEDLDRVLTVTSTD 324 >5C26-A nrPDB Length = 299 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 62/263 (23%), Positives = 123/263 (46%), Gaps = 18/263 (6%) Query: 48 KTLGTGSFGRVM--LVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV 105 K LG+G+FG V + K+ A+KIL K + + L E ++Q ++ P++V Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIV 91 Query: 106 KLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 ++ + + +VME G + +L++ + + Q+ + +YL + ++ Sbjct: 92 RM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 150 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTP-EYLAPEIILSKGYNKA 219 RDL N+L+ Q Y +++DFG +K ++ + T P ++ APE I ++ Sbjct: 151 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 210 Query: 220 VDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVD 277 D W+ GVL++E + G P+ + ++ + G ++ P+ ++ DL+ D Sbjct: 211 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 270 Query: 278 LTKRFG------NLKNGVNDIKN 294 + R G L+N D+ N Sbjct: 271 VENRPGFAAVELRLRNYYYDVVN 293 >5U6C-A nrPDB Length = 315 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 60/255 (23%), Positives = 118/255 (46%), Gaps = 22/255 (8%) Query: 48 KTLGTGSFGRVM---LVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFL 104 K LG G FG VM L + T A+K + K ++IE L+E ++ + P + Sbjct: 42 KILGEGEFGSVMEGNLKQEDGTSLKVAVKTM-KLDNSSQREIEEFLSEAACMKDFSHPNV 100 Query: 105 VKL-----EYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP-HARF-----YAAQIVL 153 ++L E S + +++ ++ G++ ++L + P H + I L Sbjct: 101 MRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIAL 160 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTP-EYLAP 208 EYL + + ++RDL N ++ + V DFG +K++ R + P +++A Sbjct: 161 GMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAI 220 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDL 266 E + + Y D WA GV ++E+A G P+ Q ++Y+ ++ G +++ P +L Sbjct: 221 ESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDEL 280 Query: 267 KDLLRNLLQVDLTKR 281 +++ + + D R Sbjct: 281 YEIMYSCWRTDPLDR 295 >4FL3-A nrPDB Length = 635 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 49/219 (22%), Positives = 103/219 (47%), Gaps = 15/219 (6%) Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149 L E ++Q ++ P++V++ + + +VME G + +L++ + + Sbjct: 418 LAEANVMQQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH 476 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTP- 203 Q+ + +YL + ++RDL N+L+ Q Y +++DFG +K ++ + T P Sbjct: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSH 261 ++ APE I ++ D W+ GVL++E + G P+ + ++ + G ++ P+ Sbjct: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG 596 Query: 262 FSSDLKDLLRNLLQVDLTKRFG------NLKNGVNDIKN 294 ++ DL+ D+ R G L+N D+ N Sbjct: 597 CPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 >3QGY-A nrPDB Length = 286 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 102/214 (47%), Gaps = 11/214 (5%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 ++ +G+G FG V L + + A+K + + + + IE E ++ ++ P LV+ Sbjct: 32 VQEIGSGQFGLVHL-GYWLNKDKVAIKTIKEGSMSEDDFIE----EAEVMMKLSHPKLVQ 86 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 L + + + +V E++ G + +LR + G F+ + YL +I+ Sbjct: 87 LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH 146 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-LCGTP---EYLAPEIILSKGYNKAVD 221 RDL N L+ + I+V+DFG + V +T GT ++ +PE+ Y+ D Sbjct: 147 RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD 206 Query: 222 WWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSG 254 W+ GVL++E+ + G P+ ++ E I +G Sbjct: 207 VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTG 240 >3KUL-B nrPDB Length = 325 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 52/204 (25%), Positives = 94/204 (46%), Gaps = 13/204 (6%) Query: 48 KTLGTGSFGRVMLVKHKETGNH---FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFL 104 K +G+G G V + + G A+K L + +Q L+E I+ + P + Sbjct: 55 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKAL--KAGYTERQRRDFLSEASIMGQFDHPNI 112 Query: 105 VKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 ++LE +V EY+ G + + LR G+F+ + YL L Sbjct: 113 IRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGY 172 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTP---EYLAPEIILSKGYN 217 ++RDL N+L+D +V+DFG ++ ++ +T G + APE I + ++ Sbjct: 173 VHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFS 232 Query: 218 KAVDWWALGVLIYE-MAAGYPPFF 240 A D W+ GV+++E +A G P++ Sbjct: 233 SASDVWSFGVVMWEVLAYGERPYW 256 >3V5Q-A nrPDB Length = 297 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 62/267 (23%), Positives = 106/267 (39%), Gaps = 32/267 (11%) Query: 48 KTLGTGSFGRVMLVKHKETGNH-----FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 + LG G+FG+V L + A+K L + K + E +L + Sbjct: 21 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQ---REAELLTNLQHE 77 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR----------------IGRFSEPHARF 146 +VK D L MV EY+ G++ LR G Sbjct: 78 HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLH 137 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP--- 203 A+QI YL S ++RDL N L+ +++ DFG ++ V + G Sbjct: 138 IASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTML 197 Query: 204 --EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKV-RFP 259 ++ PE I+ + + D W+ GV+++E+ G P+F ++ E I G+V P Sbjct: 198 PIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERP 257 Query: 260 SHFSSDLKDLLRNLLQVDLTKRFGNLK 286 ++ D++ Q + +R N+K Sbjct: 258 RVCPKEVYDVMLGCWQREPQQRL-NIK 283 >5M07-A nrPDB Length = 276 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 59/253 (23%), Positives = 101/253 (39%), Gaps = 35/253 (13%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 ++ LG + G V LV+H A+K+L + E + + P +++ Sbjct: 35 VRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPHILE 94 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE--PHARFYA--AQIVLTFEYLHSLD 162 + + + L++ M+YV G + H+ RF P A + +Y H Sbjct: 95 VHDRGEFDGQLWIAMDYVDGIDATQHM--ADRFPAVLPVGEVLAIVTAVAGALDYAHQRG 152 Query: 163 LIYRDLKPENLLIDQQGY----IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK 218 L++RD+ P N+++ Q I + DFG A + P Y APE+ + Sbjct: 153 LLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------PSYPAPELSAGADVDG 201 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP--SHFSSDLKDL---LRNL 273 D +AL + + AG PP ++ +G ++ P S F DL L L Sbjct: 202 RADQYALALTAIHLFAGAPPV---------DRSHTGPLQPPKLSAFRPDLARLDGVLSRA 252 Query: 274 LQVDLTKRFGNLK 286 L RFG+ + Sbjct: 253 LATAPADRFGSCR 265 >1AD5-A nrPDB Length = 438 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 92/211 (43%), Gaps = 21/211 (9%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 K WE A + + K LG G FG V + + + A+K + + +E Sbjct: 170 KPWEKDAWEIPR-ESLKLEKKLGAGQFGEVWMATYNKH-TKVAVKTMKPGSM----SVEA 223 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF-- 146 L E +++ + LVKL ++ +Y++ E++ G + L+ +P + Sbjct: 224 FLAEANVMKTLQHDKLVKL-HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID 282 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---TWTLCGTP 203 ++AQI ++ + I+RDL+ N+L+ ++ DFG A RV + WT Sbjct: 283 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLA-RVGAKFPIKWT----- 336 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAA 234 APE I + D W+ G+L+ E+ Sbjct: 337 ---APEAINFGSFTIKSDVWSFGILLMEIVT 364 >3HMP-A nrPDB Length = 342 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 86/186 (46%), Gaps = 21/186 (11%) Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 +YMVME ++ S L++ + Y ++ +H +++ DLKP N LI Sbjct: 131 IYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI- 188 Query: 177 QQGYIQVTDFGFAKRVKGRTWTLC-----GTPEYLAPEIILSKGYNK-----------AV 220 G +++ DFG A +++ T ++ GT Y+ PE I ++ Sbjct: 189 VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKS 248 Query: 221 DWWALGVLIYEMAAGYPPF--FADQPIQIYEKI-VSGKVRFPSHFSSDLKDLLRNLLQVD 277 D W+LG ++Y M G PF +Q +++ I + ++ FP DL+D+L+ L+ D Sbjct: 249 DVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRD 308 Query: 278 LTKRFG 283 +R Sbjct: 309 PKQRIS 314 >4Y12-A nrPDB Length = 375 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 44/151 (29%), Positives = 80/151 (52%), Gaps = 12/151 (7%) Query: 93 KRILQAVNFPFLVKLEYSFKDNSNL------YMVMEYVPGGEMFSHLRRIGRFSEPHARF 146 ++ L V P +V++ ++F ++++ Y+VMEYV GG+ + + A Sbjct: 169 RQFLAEVVHPSIVQI-FNFVEHTDRHGDPVGYIVMEYV-GGQSLKR-SKGQKLPVAEAIA 225 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYL 206 Y +I+ YLHS+ L+Y DLKPEN+++ ++ +++ D G R+ + L GTP + Sbjct: 226 YLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY-LYGTPGFQ 283 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYP 237 APEI+ + G A D + +G + + P Sbjct: 284 APEIVRT-GPTVATDIYTVGRTLAALTLDLP 313 >3PG1-A nrPDB Length = 362 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 88/201 (43%), Gaps = 15/201 (7%) Query: 89 TLNEKRILQAVNFPFLVKLEYSF-----KDNSNLYMVMEYVPGG-EMFSHLRRIGRFSEP 142 L E R+L + P ++ L F LY+V E + H +RI S Sbjct: 76 VLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIV-ISPQ 134 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTLC 200 H +++ I+L LH +++RDL P N+L+ I + DF A+ Sbjct: 135 HIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYV 194 Query: 201 GTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPF----FADQPIQIYEKIVSGK 255 Y APE+++ KG+ K VD W+ G ++ EM F F +Q +I E + + K Sbjct: 195 THRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPK 254 Query: 256 VRFPSHFSS-DLKDLLRNLLQ 275 + FSS +D LRN L Sbjct: 255 IEDVVMFSSPSARDYLRNSLS 275 >5WNL-A nrPDB Length = 342 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 108/228 (47%), Gaps = 25/228 (10%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 +F + +G+G FG+V V+H A+K V +++E L E + ++ F Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERME-LLEEAKKMEMAKFR 79 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP---HARF---YAAQIVLTFE 156 +++ + ++ L VMEY+ G + L SEP RF + + + F Sbjct: 80 YILPVYGICQEPVGL--VMEYMETGSLEKLLA-----SEPLPWDLRFRIVHETAVGMNFL 132 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-------LCGTPEYLAPE 209 + S L++ +LKP N+L+D +++++DFG AK G + + L GT YL PE Sbjct: 133 HCMSPPLLHLNLKPANILLDAHYHVKISDFGLAK-CNGMSHSHDLSMDGLFGTIAYLPPE 191 Query: 210 IILSKG--YNKAVDWWALGVLIYEMAAGYPPFFADQPI-QIYEKIVSG 254 I K ++ D ++ ++I+ + PF ++ I I K+V G Sbjct: 192 RIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKG 239 >5KMM-A nrPDB Length = 329 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/268 (23%), Positives = 109/268 (40%), Gaps = 48/268 (17%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVV--KLKQIEHTLN-----EKRILQAVNFP 102 LG G+FG+V L + H + DK V LK+ + E +L + Sbjct: 43 LGEGAFGKVFLAE-----CHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQ 97 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA-------------- 148 +V+ + L MV EY+ G++ LR G P A+ A Sbjct: 98 HIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHG----PDAKLLAGGEDVAPGPLGLGQ 153 Query: 149 -----AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--------RVKGR 195 +Q+ YL L ++RDL N L+ Q +++ DFG ++ RV GR Sbjct: 154 LLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR 213 Query: 196 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSG 254 T ++ PE IL + + D W+ GV+++E+ G P++ + + I G Sbjct: 214 TML---PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQG 270 Query: 255 K-VRFPSHFSSDLKDLLRNLLQVDLTKR 281 + + P ++ ++R Q + +R Sbjct: 271 RELERPRACPPEVYAIMRGCWQREPQQR 298 >5UIU-A nrPDB Length = 323 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 92/198 (46%), Gaps = 14/198 (7%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK-RILQAVNFPFLVKLE 108 +G G FG V K A+K L + ++++ +++ +++ LV+L Sbjct: 55 MGEGGFGVVY--KGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 112 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP---HARFYAAQIVLT-FEYLHSLDLI 164 D +L +V Y+P G + L + + P H R AQ +LH I Sbjct: 113 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDG-TPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 165 YRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTPEYLAPEIILSKGYNKA 219 +RD+K N+L+D+ +++DFG A+ + T + GT Y+APE + + K+ Sbjct: 172 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKS 231 Query: 220 VDWWALGVLIYEMAAGYP 237 D ++ GV++ E+ G P Sbjct: 232 -DIYSFGVVLLEIITGLP 248 >5MJB-A nrPDB Length = 305 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/253 (22%), Positives = 109/253 (43%), Gaps = 31/253 (12%) Query: 1 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML 60 MG+ E+V+EF + F+K E +G G FG V Sbjct: 1 MGHHHHHHGSDPNEAVREFAKEIDVSFVKIEE----------------VIGAGEFGEVYK 44 Query: 61 VKHKETGN---HFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNL 117 + K G + A+K L + KQ L+E I+ + +++LE + + Sbjct: 45 GRLKLPGKREIYVAIKTL--KAGYSEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPV 102 Query: 118 YMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 ++ E++ + S LR+ G+F+ I +YL ++ ++RDL N+L++ Sbjct: 103 MIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVN 162 Query: 177 QQGYIQVTDFGFAKRVKGRTWTLCGTPE--------YLAPEIILSKGYNKAVDWWALGVL 228 +V+DFG ++ ++ T T + APE I + + A D W+ G++ Sbjct: 163 SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIV 222 Query: 229 IYE-MAAGYPPFF 240 ++E M+ G P++ Sbjct: 223 MWEVMSFGERPYW 235 >6GVJ-A nrPDB Length = 429 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 86/186 (46%), Gaps = 21/186 (11%) Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 +YMVME ++ S L++ + Y ++ +H +++ DLKP N LI Sbjct: 219 IYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI- 276 Query: 177 QQGYIQVTDFGFAKRVKGRTWTLC-----GTPEYLAPEIILSKGYNK-----------AV 220 G +++ DFG A +++ T ++ GT Y+ PE I ++ Sbjct: 277 VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKS 336 Query: 221 DWWALGVLIYEMAAGYPPF--FADQPIQIYEKI-VSGKVRFPSHFSSDLKDLLRNLLQVD 277 D W+LG ++Y M G PF +Q +++ I + ++ FP DL+D+L+ L+ D Sbjct: 337 DVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRD 396 Query: 278 LTKRFG 283 +R Sbjct: 397 PKQRIS 402 >5GRN-A nrPDB Length = 356 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/296 (21%), Positives = 126/296 (42%), Gaps = 56/296 (18%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVML-VKHKETGNHFAMKILDK--QKVVKLKQI 86 +WE P D + LG+G+FG+V+ + + + MK+ K + + + Sbjct: 40 RWEFPR------DGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEK 93 Query: 87 EHTLNEKRILQAVNFPFL--VKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHA 144 + ++E +I+ + P L V L + + +Y++ EY G++ ++L + H Sbjct: 94 QALMSELKIMTHLG-PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHK 152 Query: 145 R--------------------------FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ 178 + + Q+ E+L S + ++RDL N+L+ Q Sbjct: 153 KKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG 212 Query: 179 GYIQVTDFGFAKRV--------KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIY 230 +++ DFG A+ + KG T+ +++APE I Y D W+ G+L++ Sbjct: 213 KIVKICDFGLARDIMHDSNYVSKGSTFLPV---KWMAPESIFDNLYTTLSDVWSYGILLW 269 Query: 231 EM----AAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 E+ YP D Y KI SG ++ P H +S++ +++ + KR Sbjct: 270 EIFSLGGTPYPGMMVDS--TFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKR 323 >4LRM-A nrPDB Length = 334 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 98/209 (46%), Gaps = 13/209 (6%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ--KVVKLKQIEHTLNEKRILQAVN 100 +F++IK LG+G+FG V G + + K+ + K + L+E ++ +V+ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 79 Query: 101 FP---FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFE 156 P + +L S + ++ + +P G + ++R + + QI Sbjct: 80 NPGNPHVCRL-LGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMN 138 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCG--TP-EYLAPEII 211 YL L++RDL N+L+ ++++TDFG AK + + + G P +++A E I Sbjct: 139 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 198 Query: 212 LSKGYNKAVDWWALGVLIYE-MAAGYPPF 239 L + Y D W+ GV ++E M G P+ Sbjct: 199 LHRIYTHQSDVWSYGVTVWELMTFGSKPY 227 >4AT3-A nrPDB Length = 299 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/236 (22%), Positives = 99/236 (41%), Gaps = 33/236 (13%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR--------ILQAV 99 + LG G+FG+V L + + + + +V +K ++ + R +L + Sbjct: 19 RELGEGAFGKVFLAEC------YNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNL 72 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-------------RFSEPHARF 146 +VK + L MV EY+ G++ LR G ++ Sbjct: 73 QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH 132 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP--- 203 A QI YL S ++RDL N L+ + +++ DFG ++ V + G Sbjct: 133 IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTML 192 Query: 204 --EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKV 256 ++ PE I+ + + D W+LGV+++E+ G P++ ++ E I G+V Sbjct: 193 PIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV 248 >5WNO-A nrPDB Length = 330 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/234 (24%), Positives = 102/234 (43%), Gaps = 10/234 (4%) Query: 48 KTLGTGSFGRVML-VKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 K LG G+FG V + + + + + + K Q + L E + + L+K Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLK 87 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 + + L +V Y P G + + L+ Y QI +YL +++ Sbjct: 88 IIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVH 147 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP-----EYLAPEIILSKGYNKAV 220 RDL N+L+ + ++++TDFG +K +K ++ ++LA EI Y A Sbjct: 148 RDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHAS 207 Query: 221 DWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDL-KDLLR 271 D WA GV +E+ G P+ I+ + G ++ P + S DL ++LLR Sbjct: 208 DVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLR 261 >6FEX-A nrPDB Length = 321 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 38/218 (17%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKI-LDKQK------VVKLKQIEHT-------LNEKRI 95 LG G FG V L + + ++ L+ +K VK+ + + T L E +I Sbjct: 24 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKI 83 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-------------IGRFSEP 142 + + P +++L + L M+ +Y+ G++ L S P Sbjct: 84 MSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDPTISYP 143 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--------RVKG 194 AAQI YL +L+ ++RDL N L+ + I++ DFG ++ RV+G Sbjct: 144 MLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQG 203 Query: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232 R ++A E IL + A D WA GV ++E+ Sbjct: 204 RAVL---PIRWMAWECILMGKFTTASDVWAFGVTLWEV 238 >4XLV-A nrPDB Length = 328 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/262 (22%), Positives = 115/262 (43%), Gaps = 34/262 (12%) Query: 47 IKTLGTGSFGRVML-----VKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++ LG GSFG V + E A+K +++ ++ ++IE LNE +++ Sbjct: 44 LRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLR-ERIEF-LNEASVMKGFTC 101 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE-----PHARF-----YAAQI 151 +V+L +VME + G++ S+LR + +E P AA+I Sbjct: 102 HHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEI 161 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP-----EYL 206 YL++ ++RDL N ++ +++ DFG + + + G ++ Sbjct: 162 ADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM 221 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ--IYEKIV-----SGKVRFP 259 APE + + + D W+ GV+++E+ + A+QP Q E+++ G + P Sbjct: 222 APESLKDGVFTTSSDMWSFGVVLWEITS-----LAEQPYQGLSNEQVLKFVMDGGYLDQP 276 Query: 260 SHFSSDLKDLLRNLLQVDLTKR 281 + + DL+R Q + R Sbjct: 277 DNCPERVTDLMRMCWQFNPNMR 298 >2OGV-A nrPDB Length = 317 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/244 (25%), Positives = 109/244 (44%), Gaps = 32/244 (13%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ 78 F+ + + +KWE P N QF KTLG G+FG+V+ G A+ K Sbjct: 21 FIDPTQLPYNEKWEFPRNNL----QFG--KTLGAGAFGKVVEATAFGLGKEDAVL---KV 71 Query: 79 KVVKLKQIEHT------LNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 V LK H ++E +I+ + +V L + + ++ EY G++ + Sbjct: 72 AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLN 131 Query: 132 HLRRI---------GRFSEPHARF-YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI 181 LRR GR E +++Q+ +L S + I+RD+ N+L+ Sbjct: 132 FLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA 191 Query: 182 QVTDFGFAKRVKGRT-WTLCGTP----EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAG 235 ++ DFG A+ + + + + G +++APE I Y D W+ G+L++E+ + G Sbjct: 192 KIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLG 251 Query: 236 YPPF 239 P+ Sbjct: 252 LNPY 255 >5HLW-A nrPDB Length = 299 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/233 (22%), Positives = 106/233 (45%), Gaps = 19/233 (8%) Query: 48 KTLGTGSFGRV---MLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP-F 103 + +G G FG V L+ + H A+K L++ + + ++ L E I++ + P Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHPNV 83 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR---FYAAQIVLTFEYLHS 160 L L + + +V+ Y+ G++ + +R P + + Q+ +YL S Sbjct: 84 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRN--ETHNPTVKDLIGFGLQVAKGMKYLAS 141 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW------TLCGTP-EYLAPEIILS 213 ++RDL N ++D++ ++V DFG A+ + + + T P +++A E + + Sbjct: 142 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQT 201 Query: 214 KGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSD 265 + + D W+ GVL++E M G PP+ I ++ G+ + D Sbjct: 202 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD 254 >2ZMD-A nrPDB Length = 390 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 47/186 (25%), Positives = 85/186 (45%), Gaps = 21/186 (11%) Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 +YMVME ++ S L++ + Y ++ +H +++ DLKP N LI Sbjct: 131 IYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI- 188 Query: 177 QQGYIQVTDFGFAKRVKGRTWTLC-----GTPEYLAPEIILSKGYNK-----------AV 220 G +++ DFG A +++ T ++ G Y+ PE I ++ Sbjct: 189 VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKS 248 Query: 221 DWWALGVLIYEMAAGYPPF--FADQPIQIYEKI-VSGKVRFPSHFSSDLKDLLRNLLQVD 277 D W+LG ++Y M G PF +Q +++ I + ++ FP DL+D+L+ L+ D Sbjct: 249 DVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRD 308 Query: 278 LTKRFG 283 +R Sbjct: 309 PKQRIS 314 >5H2U-A nrPDB Length = 267 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/204 (23%), Positives = 95/204 (46%), Gaps = 10/204 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++F + LG+G FG V K+ A+K++ + ++ + ++ +E + ++ + Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDRVQ-VAIKVISRDNLLHQQMLQ---SEIQAMKKLRH 61 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY--AAQIVLTFEYLH 159 ++ L +Y++ E + G + LR P + A Q+ YL Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL--CGTP-EYLAPEIILSKGY 216 S + I+RDL N+L+ + +V DFG A+ +K + P ++ APE + Y Sbjct: 122 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHY 181 Query: 217 NKAVDWWALGVLIYEM-AAGYPPF 239 + D W+ G+L++EM + G P+ Sbjct: 182 STKSDVWSFGILLHEMFSRGQVPY 205 >4F0G-A nrPDB Length = 287 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 105/217 (48%), Gaps = 26/217 (11%) Query: 42 DQFERIKTLGTGSFGRV---MLVKHKETGNHFAMKILDKQKVVKL-KQIEHTLNEKRILQ 97 ++ E K +G G FG V LVK K ++ + D + ++ ++ + E I+ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ------I 151 +N P +VKL Y N MVME+VP G+++ L + H ++ + I Sbjct: 79 NLNHPNIVKL-YGLMHNPP-RMVMEFVPCGDLYHRL-----LDKAHPIKWSVKLRLMLDI 131 Query: 152 VLTFEYLHSLD--LIYRDLKPENLL---IDQQGYI--QVTDFGFAKRVKGRTWTLCGTPE 204 L EY+ + + +++RDL+ N+ +D+ + +V DFG +++ L G + Sbjct: 132 ALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQ 191 Query: 205 YLAPEIILS--KGYNKAVDWWALGVLIYEMAAGYPPF 239 ++APE I + + Y + D ++ +++Y + G PF Sbjct: 192 WMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPF 228 >4CRL-A nrPDB Length = 406 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 49/188 (26%), Positives = 87/188 (46%), Gaps = 27/188 (14%) Query: 83 LKQIEHT------LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI 136 LKQIE T E +L+ + P ++ L+ F +++ + + + H+ + Sbjct: 54 LKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKF 113 Query: 137 GRFSEPH----------ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI----DQQGYIQ 182 R S+ + + QI+ YLH+ +++RDLKP N+L+ ++G ++ Sbjct: 114 HRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVK 173 Query: 183 VTDFGFAKRVKGRTWTLCG------TPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAG 235 + D GFA+ L T Y APE++L ++ Y KA+D WA+G + E+ Sbjct: 174 IADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTS 233 Query: 236 YPPFFADQ 243 P F Q Sbjct: 234 EPIFHCRQ 241 >4C59-A nrPDB Length = 340 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 46/140 (32%), Positives = 67/140 (47%), Gaps = 24/140 (17%) Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTW------------TLCGTPEYLA 207 +I+RDLK ENLL+ QG I++ DFG A + +W T TP Y Sbjct: 158 IIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRT 217 Query: 208 PEII-LSKGY--NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS- 263 PEII L + + D WALG ++Y + PF + +IV+GK P H + Sbjct: 218 PEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL----RIVNGKYSIPPHDTQ 273 Query: 264 -SDLKDLLRNLLQVDLTKRF 282 + L+R +LQV+ +R Sbjct: 274 YTVFHSLIRAMLQVNPEERL 293 >5AP3-A nrPDB Length = 313 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 47/186 (25%), Positives = 85/186 (45%), Gaps = 21/186 (11%) Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 +YMVME ++ L++ + Y ++ +H +++ DLKP N LI Sbjct: 103 IYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI- 160 Query: 177 QQGYIQVTDFGFAKRVKGRTWTLC-----GTPEYLAPEIILSKGYNK-----------AV 220 G +++ DFG A +++ T ++ GT Y+ PE I ++ Sbjct: 161 VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKS 220 Query: 221 DWWALGVLIYEMAAGYPPF--FADQPIQIYEKI-VSGKVRFPSHFSSDLKDLLRNLLQVD 277 D W+LG ++Y M G PF +Q +++ I + ++ FP DL+D+L+ L+ D Sbjct: 221 DVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRD 280 Query: 278 LTKRFG 283 +R Sbjct: 281 PKQRIS 286 >6J5U-C nrPDB Length = 426 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 91/212 (42%), Gaps = 25/212 (11%) Query: 44 FERIKTLGTGSFGRV---------MLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 F + LG G FG V + +G A+K L + K+ L E Sbjct: 86 FRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEW---LTEVN 142 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV-- 152 L ++ P LV L + N +V E++P G + +HL R R ++P ++ Sbjct: 143 YLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFR--RGAQPLTWAIRMKVAVG 200 Query: 153 ----LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-----LCGTP 203 LTF + +IYRD K N+L+D +++DFG AK T + GT Sbjct: 201 AAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAG 235 Y APE + + D ++ GV++ E+ +G Sbjct: 261 GYAAPEYVATGRLTAKSDVYSFGVVLLELISG 292 >4NT4-A nrPDB Length = 312 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 100/240 (41%), Gaps = 24/240 (10%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 K +G G+FG + L K+ H A+K+ + +E+ + A N P + Sbjct: 18 KKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPR 77 Query: 108 EYSFKDNSNLY--MVMEYVPGG--EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 Y Y MV+E + ++F+ R +FS A Q++ EY+HS L Sbjct: 78 IYHLGTCGGRYNAMVLELLGLSLEDLFNICAR--KFSLKTVLMIAKQLLHRIEYVHSRHL 135 Query: 164 IYRDLKPENLLID-----QQGYIQVTDFGFAK---------RVKGRTW-TLCGTPEYLAP 208 IYRD+KPEN LI ++ I + DFG AK + R +L GT Y++ Sbjct: 136 IYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSI 195 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFPSHFSSD 265 + + ++ D ALG + G P AD + Y+KI K P D Sbjct: 196 NTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCD 255 >5U6B-A nrPDB Length = 307 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 58/255 (22%), Positives = 117/255 (45%), Gaps = 22/255 (8%) Query: 48 KTLGTGSFGRVM--LVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV 105 KTLG G FG VM + ++ A+K + K + ++E L+E ++ + P ++ Sbjct: 29 KTLGEGEFGAVMEGQLNQDDSILKVAVKTM-KIAICTRSELEDFLSEAVCMKEFDHPNVM 87 Query: 106 KL-EYSFKDNSN-----LYMVMEYVPGGEMFSHL--RRIGR----FSEPHARFYAAQIVL 153 +L F+ + +++ ++ G++ S L R+G + A I Sbjct: 88 RLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIAS 147 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTP-EYLAP 208 EYL + I+RDL N ++++ + V DFG +K++ R + P +++A Sbjct: 148 GMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAI 207 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDL 266 E + + Y D W+ GV ++E+A G P+ + +IY+ + G +++ P+ L Sbjct: 208 ESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGL 267 Query: 267 KDLLRNLLQVDLTKR 281 L+ +++ R Sbjct: 268 YALMSRCWELNPQDR 282 >3HNG-A nrPDB Length = 360 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 41/159 (25%), Positives = 78/159 (49%), Gaps = 16/159 (10%) Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTP-- 203 Y+ Q+ E+L S I+RDL N+L+ + +++ DFG A+ + K + G Sbjct: 204 YSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRL 263 Query: 204 --EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSG-----K 255 +++APE I K Y+ D W+ GVL++E+ + G P+ +Q+ E S + Sbjct: 264 PLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPG---VQMDEDFCSRLREGMR 320 Query: 256 VRFPSHFSSDLKDLLRNLLQVDLTK--RFGNLKNGVNDI 292 +R P + + ++ ++ + D + RF L + D+ Sbjct: 321 MRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDL 359 >6EII-A nrPDB Length = 352 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 59/100 (59%), Gaps = 4/100 (4%) Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK-GRTWTLCGT 202 RFY +I+ +Y HS+ +++RD+KP N++ID + +++ D+G A+ G+ + + Sbjct: 157 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 216 Query: 203 PEYL-APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF 240 Y PE+++ + Y+ ++D W+LG ++ M PFF Sbjct: 217 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 256 >6HMD-A nrPDB Length = 365 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 37/129 (28%), Positives = 71/129 (55%), Gaps = 7/129 (5%) Query: 119 MVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-Q 177 +V EY+ + F L +I ++ RFY +++ +Y HS +++RD+KP N++ID Q Sbjct: 127 LVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQ 183 Query: 178 QGYIQVTDFGFAKRVK-GRTWTLCGTPEYL-APEIILS-KGYNKAVDWWALGVLIYEMAA 234 Q +++ D+G A+ + + + Y PE+++ + Y+ ++D W+LG ++ M Sbjct: 184 QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 243 Query: 235 GYPPFFADQ 243 PFF Q Sbjct: 244 RREPFFHGQ 252 >5XVU-A nrPDB Length = 332 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 34/119 (28%), Positives = 67/119 (56%), Gaps = 9/119 (7%) Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-YIQVTDFGFAKRVK-GR 195 +F++ R+Y QI+ +Y HS +++RD+KP N++ID + I++ +G A+ G+ Sbjct: 121 KFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQ 180 Query: 196 TWTL-CGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFA-----DQPIQI 247 + + + Y PE+++ + Y+ ++D W+LG ++ M PFF DQ ++I Sbjct: 181 EYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKI 239 >2BUJ-A nrPDB Length = 317 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 65/264 (24%), Positives = 118/264 (44%), Gaps = 35/264 (13%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMK-ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV 105 I+ LG G F V LV+ G+ +A+K IL ++ + E E + + N P ++ Sbjct: 34 IQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQ----QDREEAQREADMHRLFNHPNIL 89 Query: 106 KL-EYSFKDNS---NLYMVMEYVPGGEMFSHLRRI---GRF-SEPHARFYAAQIVLTFEY 157 +L Y ++ ++++ + G +++ + R+ G F +E + I E Sbjct: 90 RLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEA 149 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR----VKGRTWTLC--------GTPEY 205 +H+ +RDLKP N+L+ +G + D G + V+G L T Y Sbjct: 150 IHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISY 209 Query: 206 LAPEIILSKGY---NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI---VSGKVRFP 259 APE+ + + ++ D W+LG ++Y M G P+ D Q + + V ++ P Sbjct: 210 RAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY--DMVFQKGDSVALAVQNQLSIP 267 Query: 260 S--HFSSDLKDLLRNLLQVDLTKR 281 SS L LL +++ VD +R Sbjct: 268 QSPRHSSALWQLLNSMMTVDPHQR 291 >6BSD-A nrPDB Length = 876 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 94/224 (41%), Gaps = 44/224 (19%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKI-LDKQK------VVKLKQIEHT-------LNEKRI 95 LG G FG V L + + ++ L+ +K VK+ + + T L E +I Sbjct: 579 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKI 638 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-------------------RI 136 + + P +++L + L M+ +Y+ G++ L + Sbjct: 639 MSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQG 698 Query: 137 GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK------ 190 S P AAQI YL +L+ ++RDL N L+ + I++ DFG ++ Sbjct: 699 PTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGD 758 Query: 191 --RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232 RV+GR ++A E IL + A D WA GV ++E+ Sbjct: 759 YYRVQGRAVLPI---RWMAWECILMGKFTTASDVWAFGVTLWEV 799 >3VHK-A nrPDB Length = 368 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 69/134 (51%), Gaps = 12/134 (8%) Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCG 201 H Y+ Q+ E+L S I+RDL N+L+ ++ +++ DFG A+ + K + G Sbjct: 201 HLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG 260 Query: 202 TP----EYLAPEIILSKGYNKAVDWWALGVLIYEM----AAGYPPFFADQPIQIYEKIVS 253 +++APE I + Y D W+ GVL++E+ A+ YP D+ + ++ Sbjct: 261 DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDE--EFCRRLKE 318 Query: 254 G-KVRFPSHFSSDL 266 G ++R P + + ++ Sbjct: 319 GTRMRAPDYTTPEM 332 >3LMG-A nrPDB Length = 344 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 95/210 (45%), Gaps = 18/210 (8%) Query: 43 QFERIKTLGTGSFGRVMLVKHKET--GNHFAMKILDKQKVVKLKQ----IEHTLNEKRIL 96 + ++K LG+G FG V HK ++KI KV++ K + + + Sbjct: 32 ELRKLKVLGSGVFGTV----HKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI 87 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF-YAAQIVLTF 155 +++ +V+L S+L +V +Y+P G + H+R+ P + QI Sbjct: 88 GSLDHAHIVRL-LGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGM 146 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV----KGRTWTLCGTP-EYLAPEI 210 YL +++R+L N+L+ +QV DFG A + K ++ TP +++A E Sbjct: 147 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 206 Query: 211 ILSKGYNKAVDWWALGVLIYE-MAAGYPPF 239 I Y D W+ GV ++E M G P+ Sbjct: 207 IHFGKYTHQSDVWSYGVTVWELMTFGAEPY 236 >5AR8-A nrPDB Length = 326 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/231 (23%), Positives = 99/231 (42%), Gaps = 29/231 (12%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 ++ L G+ G V +H + A+K L + + + L E IL F +++ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE---PHARFYAAQIVLTFEYLHSLD- 162 + + L +V EY+P G + L R + + P +I L YLH++ Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 163 -LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC--------------GTPEYLA 207 L++ DLK +N+L+D + ++++ DFG +K W + GT Y+ Sbjct: 157 PLLHHDLKTQNILLDNEFHVKIADFGLSK------WRMMSLSQSRSSKSAPEGGTIIYMP 210 Query: 208 PEIILSKGYNKAV---DWWALGVLIYEMAAGYPPFF-ADQPIQIYEKIVSG 254 PE ++A D ++ V+ +E+ + PF P+QI + G Sbjct: 211 PENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQG 261 >3KRL-A nrPDB Length = 335 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 59/250 (23%), Positives = 108/250 (43%), Gaps = 38/250 (15%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ 78 F+ + + +KWE P N QF KTLG G+FG+V+ G A+ K Sbjct: 29 FIDPTQLPYNEKWEFPRNNL----QFG--KTLGAGAFGKVVEATAFGLGKEDAVL---KV 79 Query: 79 KVVKLKQIEHT------LNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 V LK H ++E +I+ + +V L + + ++ EY G++ + Sbjct: 80 AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLN 139 Query: 132 HLRRIG----------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI 175 LRR + S +++Q+ +L S + I+RD+ N+L+ Sbjct: 140 FLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL 199 Query: 176 DQQGYIQVTDFGFAKRVKGRT-WTLCGTP----EYLAPEIILSKGYNKAVDWWALGVLIY 230 ++ DFG A+ + + + + G +++APE I Y D W+ G+L++ Sbjct: 200 TNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLW 259 Query: 231 EM-AAGYPPF 239 E+ + G P+ Sbjct: 260 EIFSLGLNPY 269 >4MD7-E nrPDB Length = 391 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 59/100 (59%), Gaps = 4/100 (4%) Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK-GRTWTLCGT 202 RFY +I+ +Y HS+ +++RD+KP N++ID + +++ D+G A+ G+ + + Sbjct: 134 RFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVA 193 Query: 203 PEYL-APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF 240 Y PE+++ + Y+ ++D W+LG ++ M PFF Sbjct: 194 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF 233 >4F9B-A nrPDB Length = 361 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 62/263 (23%), Positives = 113/263 (42%), Gaps = 56/263 (21%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ 78 LA K+D K +E Q + + F+ +G G+F V L + +++ ++ Sbjct: 1 MLAGVKKDIEKLYEAVPQLS---NVFKIEDKIGEGTFSSVYLATAQ-------LQVGPEE 50 Query: 79 KVVKLKQIEHTLNEKRI---LQAVNFPF----LVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 K+ LK + T + RI LQ + ++ ++Y F+ N ++ + M Y+ E S Sbjct: 51 KIA-LKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYL---EHES 106 Query: 132 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ-GYIQVTDFGFAK 190 L + S R Y + + +H +++RD+KP N L +++ + DFG A+ Sbjct: 107 FLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQ 166 Query: 191 --------------------RVKGRTWTLC-----------GTPEYLAPEIILSKGYNK- 218 R ++C GTP + APE +L+K N+ Sbjct: 167 GTHDTKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPE-VLTKCPNQT 225 Query: 219 -AVDWWALGVLIYEMAAGYPPFF 240 A+D W+ GV+ + +G PF+ Sbjct: 226 TAIDMWSAGVIFLSLLSGRYPFY 248 >2CHL-A nrPDB Length = 351 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 80/317 (25%), Positives = 134/317 (42%), Gaps = 38/317 (11%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 K +G G+FG + L K+ T + A+K+ + +E+ K++ P + Sbjct: 36 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIPQVYYF 94 Query: 108 EYSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 K N+ MV+E + P E +F R FS A Q++ EY+HS +LIY Sbjct: 95 GPCGKYNA---MVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHSKNLIY 149 Query: 166 RDLKPENLLIDQQG-----YIQVTDFGFAKR-VKGRT---------WTLCGTPEYLAPEI 210 RD+KPEN LI + G I + DF AK + T +L GT Y++ Sbjct: 150 RDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINT 209 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFPSHFSS--- 264 L K ++ D ALG + G P AD + Y+KI K P Sbjct: 210 HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF 269 Query: 265 -DLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFA---TTDWIAIYQRKVEAPFIPK 318 ++ LR + ++D ++ + L+ D+ + K + DWI +++ P Sbjct: 270 PEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIG---KQLPTPVGAV 326 Query: 319 FKGPGDTSNFDDYEEEE 335 + P +SN + ++ + Sbjct: 327 QQDPALSSNREAHQHRD 343 >3C1X-A nrPDB Length = 373 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 48/207 (23%), Positives = 99/207 (47%), Gaps = 19/207 (9%) Query: 48 KTLGTGSFGRV---MLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP-F 103 + +G G FG V L+ + H A+K L++ + + ++ L E I++ + P Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHPNV 152 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR---FYAAQIVLTFEYLHS 160 L L + + +V+ Y+ G++ + +R P + + Q+ ++L S Sbjct: 153 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRN--ETHNPTVKDLIGFGLQVAKGMKFLAS 210 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW------TLCGTP-EYLAPEIILS 213 ++RDL N ++D++ ++V DFG A+ + + + T P +++A E + + Sbjct: 211 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQT 270 Query: 214 KGYNKAVDWWALGVLIYE-MAAGYPPF 239 + + D W+ GVL++E M G PP+ Sbjct: 271 QKFTTKSDVWSFGVLLWELMTRGAPPY 297 >2C47-A nrPDB Length = 313 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 69/255 (27%), Positives = 110/255 (43%), Gaps = 31/255 (12%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 K +G G+FG + L K+ T + A+K+ + +E+ K++ P + Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFY-KQLSATEGVPQVYYF 68 Query: 108 EYSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 K N+ MV+E + P E +F R F+ A Q++ EY+H+ LIY Sbjct: 69 GPCGKYNA---MVLELLGPSLEDLFDLCDRT--FTLKTVLMIAIQLITRMEYVHTKSLIY 123 Query: 166 RDLKPENLLIDQQGY-----IQVTDFGFAKR-VKGRT---------WTLCGTPEYLAPEI 210 RD+KPEN L+ + G I + DFG AK + T +L GT Y++ Sbjct: 124 RDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINT 183 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFP-----SHF 262 L K ++ D ALG + G P AD + Y+KI K P +F Sbjct: 184 HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF 243 Query: 263 SSDLKDLLRNLLQVD 277 ++ LR + ++D Sbjct: 244 PEEMATYLRYVRRLD 258 >4L00-A nrPDB Length = 304 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 84/182 (46%), Gaps = 13/182 (7%) Query: 110 SFKDNSNLYMVMEYVPGG--EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRD 167 +D N+ MV E+V GG ++F H R+ + P A Q+ YL DL++ + Sbjct: 101 CVRDVENI-MVEEFVEGGPLDLFMH-RKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGN 158 Query: 168 LKPENLLIDQQG-------YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL-SKGYNKA 219 + +NLL+ ++G +I+++D G V R + P ++APE + SK + A Sbjct: 159 VCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP-WIAPECVEDSKNLSVA 217 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLT 279 D W+ G ++E+ D+ + E+ + R + +L DL+ + D Sbjct: 218 ADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPN 277 Query: 280 KR 281 +R Sbjct: 278 QR 279 >2PL0-A nrPDB Length = 289 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/252 (22%), Positives = 108/252 (42%), Gaps = 24/252 (9%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT 89 +WE P + + ++ LG G FG V + + A+K L + + + Sbjct: 17 EWEVPRET------LKLVERLGAGQFGEVWM-GYYNGHTKVAVKSLKQGSMSP----DAF 65 Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF--Y 147 L E +++ + LV+L Y+ +Y++ EY+ G + L+ + Sbjct: 66 LAEANLMKQLQHQRLVRL-YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDM 124 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTP- 203 AAQI ++ + I+RDL+ N+L+ ++ DFG A+ ++ +T P Sbjct: 125 AAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPI 184 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAA----GYPPFFADQPIQIYEKIVSGKVRFP 259 ++ APE I + D W+ G+L+ E+ YP + IQ E+ ++ P Sbjct: 185 KWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLER--GYRMVRP 242 Query: 260 SHFSSDLKDLLR 271 + +L L+R Sbjct: 243 DNCPEELYQLMR 254 >4LFI-A nrPDB Length = 374 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 47/204 (23%) Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-YIQVTDFGFAK--RVKG 194 + ++ RFY +++ +Y HS+ +++RD+KP N++ID + +++ D+G A+ V Sbjct: 168 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 227 Query: 195 RTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI- 247 + + PE+++ + Y+ ++D W+ G ++ M PFF DQ ++I Sbjct: 228 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 287 Query: 248 -------YEK-IVSGKVRFPSHF------------------------SSDLKDLLRNLLQ 275 +EK ++ ++ P F + ++ DL+ NLL+ Sbjct: 288 KVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 347 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFA 299 D +R + H WFA Sbjct: 348 YDHQERL-----TAKEAMGHPWFA 366 >4R7H-A nrPDB Length = 343 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 60/257 (23%), Positives = 109/257 (42%), Gaps = 45/257 (17%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ 78 F+ + + +KWE P N QF KTLG G+FG+V+ G A+ K Sbjct: 33 FIDPTQLPYNEKWEFPRNNL----QFG--KTLGAGAFGKVVEATAFGLGKEDAVL---KV 83 Query: 79 KVVKLKQIEHT------LNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 V LK H ++E +I+ + +V L + + ++ EY G++ + Sbjct: 84 AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLN 143 Query: 132 HLRR-----IGRFSEPHAR------------------FYAAQIVLTFEYLHSLDLIYRDL 168 LRR +G P +++Q+ +L S + I+RD+ Sbjct: 144 FLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDV 203 Query: 169 KPENLLIDQQGYIQVTDFGFAKRVKGRT-WTLCGTP----EYLAPEIILSKGYNKAVDWW 223 N+L+ ++ DFG A+ + + + + G +++APE I Y D W Sbjct: 204 AARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVW 263 Query: 224 ALGVLIYEM-AAGYPPF 239 + G+L++E+ + G P+ Sbjct: 264 SYGILLWEIFSLGLNPY 280 >5FQD-C nrPDB Length = 341 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 65/234 (27%), Positives = 107/234 (45%), Gaps = 22/234 (9%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-VNF 101 +++ ++ +G+GSFG + L + G A+K L+ QK + Q+ + +ILQ V Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKA-RHPQLLYESKLYKILQGGVGI 77 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++ KD + L M + ++F+ R RF+ A Q++ EY+H+ Sbjct: 78 PH-IRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMKTVLMLADQMISRIEYVHTK 134 Query: 162 DLIYRDLKPENLLIDQQGYIQ---VTDFGFAKRVK-GRTW---------TLCGTPEYLAP 208 + I+RD+KP+N L+ + + DFG AK+ + RT L GT Y + Sbjct: 135 NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASI 194 Query: 209 EIILSKGYNKAVDWWALG-VLIYEMAAGYP--PFFADQPIQIYEKIVSGKVRFP 259 L ++ D +LG VL+Y P A Q YEKI K+ P Sbjct: 195 NAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTP 248 >4TN6-A nrPDB Length = 318 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 103/233 (44%), Gaps = 30/233 (12%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK--RILQA-VNFPFL 104 + +G+GSFG + L G A+K+ + VK K + + K +++Q V P Sbjct: 13 RKIGSGSFGDIYLGTDIAAGEEVAIKL----ECVKTKHPQLHIESKIYKMMQGGVGIP-- 66 Query: 105 VKLEYSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 + + + MVME + P E +F+ R +FS A Q++ EY+HS + Sbjct: 67 -TIRWCGAEGDYNVMVMELLGPSLEDLFNFCSR--KFSLKTVLLLADQMISRIEYIHSKN 123 Query: 163 LIYRDLKPENLLID---QQGYIQVTDFGFAKRVK-GRTW---------TLCGTPEYLAPE 209 I+RD+KP+N L+ + + + DFG AK+ + RT L GT Y + Sbjct: 124 FIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASIN 183 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKVRFP 259 L ++ D +LG ++ G P A Q YE+I K+ P Sbjct: 184 THLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTP 236 >3I81-A nrPDB Length = 315 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 97/219 (44%), Gaps = 27/219 (12%) Query: 48 KTLGTGSFGRVML-----VKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 + LG GSFG V V E A+K +++ ++ ++IE LNE +++ N Sbjct: 24 RELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMR-ERIEF-LNEASVMKEFNCH 81 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF----------YAAQIV 152 +V+L ++ME + G++ S+LR + E + A +I Sbjct: 82 HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIA 141 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP-----EYLA 207 YL++ ++RDL N ++ + +++ DFG + + + G +++ Sbjct: 142 DGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMS 201 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 246 PE + + D W+ GV+++E+A A+QP Q Sbjct: 202 PESLKDGVFTTYSDVWSFGVVLWEIAT-----LAEQPYQ 235 >5IKW-A nrPDB Length = 310 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 82/198 (41%), Gaps = 36/198 (18%) Query: 110 SFKDNS-NLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLHSLD--LI 164 S DN + ++MEY G++ + + + + F+EP LH +I Sbjct: 83 SISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPII 142 Query: 165 YRDLKPENLLIDQQGYIQVTDFGFA----------------KRVKGRTWTLCGTPEYLAP 208 +RDLK EN+L++ G + DFG A + +K T T Y AP Sbjct: 143 HRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT-----TLSYRAP 197 Query: 209 EIIL---SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP--SHFS 263 E+I K D WALG L+Y++ PF Q I G P S +S Sbjct: 198 EMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ-----VAICDGNFTIPDNSRYS 252 Query: 264 SDLKDLLRNLLQVDLTKR 281 ++ L+R +L+ D R Sbjct: 253 RNIHCLIRFMLEPDPEHR 270 >5TE0-A nrPDB Length = 347 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 51/188 (27%), Positives = 82/188 (43%), Gaps = 31/188 (16%) Query: 117 LYMVMEYVPGGEMFSHL--RRIGRFSEPHARFYAAQIVLTFEYLHSLD--LIYRDLKPEN 172 + ++M++ GG++ + + R F+E LH +I+RDLK EN Sbjct: 97 VLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVEN 156 Query: 173 LLIDQQGYIQVTDFGFAK------RVKG--------RTWTLCGTPEYLAPEII---LSKG 215 +L+ +G+ + DFG A + +G + +T T Y APE++ K Sbjct: 157 ILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT---TLSYRAPEMVNLYSGKI 213 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP--SHFSSDLKDLLRNL 273 D WALG L+Y++ PF Q I G P S +S D+ L+R + Sbjct: 214 ITTKADIWALGCLLYKLCYFTLPFGESQ-----VAICDGNFTIPDNSRYSQDMHCLIRYM 268 Query: 274 LQVDLTKR 281 L+ D KR Sbjct: 269 LEPDPDKR 276 >1LUF-A nrPDB Length = 343 Score = 53.9 bits (128), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 54/266 (20%), Positives = 106/266 (39%), Gaps = 38/266 (14%) Query: 42 DQFERIKTLGTGSFGRVMLVKHK-----ETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 + E ++ +G G+FGRV + E A+K+L ++ ++ E ++ Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQA--DFQREAALM 104 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI----------------GRFS 140 + P +VKL + ++ EY+ G++ LR + R S Sbjct: 105 AEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVS 164 Query: 141 EP--------HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV 192 P A Q+ YL ++RDL N L+ + +++ DFG ++ + Sbjct: 165 SPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI 224 Query: 193 KGRTWTLC----GTP-EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQ 246 + P ++ PE I Y D WA GV+++E+ + G P++ + Sbjct: 225 YSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEE 284 Query: 247 IYEKIVSGKV-RFPSHFSSDLKDLLR 271 + + G + P + +L +L+R Sbjct: 285 VIYYVRDGNILACPENCPLELYNLMR 310 >5X18-A nrPDB Length = 295 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 96/226 (42%), Gaps = 30/226 (13%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVK 106 K +G GSFG +L + N + I + + + Q+ +IL N P+ Sbjct: 13 KKIGEGSFG--VLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPY--- 67 Query: 107 LEYSFKDNS--NLYMVMEYVPGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 Y F N+ ++ P E +F R +FS A Q++ E LH+ DL Sbjct: 68 -AYYFGQEGLHNILVIDLLGPSLEDLFDWCGR--KFSVKTVVQVAVQMITLIEDLHAHDL 124 Query: 164 IYRDLKPENLLIDQQGY-----IQVTDFGFAKRVKG----------RTWTLCGTPEYLAP 208 IYRD+KP+N LI + G I + DFG AK+ + +L GT Y++ Sbjct: 125 IYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSI 184 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKI 251 L + ++ D ALG + + G+ P A Q YEKI Sbjct: 185 NTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKI 230 >5VDK-A nrPDB Length = 297 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/276 (23%), Positives = 109/276 (39%), Gaps = 49/276 (17%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV--- 99 +F ++ +G G FG V + G +A+K +K NE L V Sbjct: 16 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIK-------RSMKTFTELSNENSALHEVYAH 68 Query: 100 ----NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL----RRIGRFSEPHARFYAAQI 151 + P +V+ S+ ++ ++ + EY GG + + + + F EP + QI Sbjct: 69 AVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQI 128 Query: 152 VLTFEYLHSLDLIYRDLKPENLLI------DQQGYIQ-----------------VTDFGF 188 L Y+H+ +++ D+KP N+ I + G I+ + D G Sbjct: 129 SLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGH 188 Query: 189 AKRVKGRTWTLCGTPEYLAPEIILSKGYNK--AVDWWALGVLIYEMAAGYPPFFADQPIQ 246 A + + G +LA E IL + Y D +ALG+ I +AAG + Sbjct: 189 ATSIN-KPKVEEGDSRFLANE-ILQEDYRHLPKADIFALGLTI-AVAAGAESLPTNG--A 243 Query: 247 IYEKIVSGKV-RFPSHFSSDLKDLLRNLLQVDLTKR 281 + I G P S LL+N++Q D +R Sbjct: 244 AWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQR 279 >2Y4I-B nrPDB Length = 319 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 109/256 (42%), Gaps = 53/256 (20%) Query: 15 SVKEFLAKAKED--FLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAM 72 S + F KA + FL++W+ P +Q E + +G G FG+V H A+ Sbjct: 10 SARSFPRKASQTSIFLQEWDIP------FEQLEIGELIGKGRFGQVY---HGRWHGEVAI 60 Query: 73 KILD------------KQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMV 120 +++D K++V+ +Q H N + A P + + S LY V Sbjct: 61 RLIDIERDNEDQLKAFKREVMAYRQTRHE-NVVLFMGACMSPPHLAIITSLCKGRTLYSV 119 Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 + + R+I A +IV YLH+ ++++DLK +N+ D G Sbjct: 120 VRDAKIVLDVNKTRQI-----------AQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGK 167 Query: 181 IQVTDFGF--------AKRVKGRTWTLCGTPEYLAPEII--LSKG-------YNKAVDWW 223 + +TDFG A R + + G +LAPEII LS ++K D + Sbjct: 168 VVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVF 227 Query: 224 ALGVLIYEMAAGYPPF 239 ALG + YE+ A PF Sbjct: 228 ALGTIWYELHAREWPF 243 >3SV0-A nrPDB Length = 483 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 68/257 (26%), Positives = 113/257 (43%), Gaps = 47/257 (18%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK--RILQA- 98 ++F + +G+GSFG + L + +T A+K+ + VK K + K RILQ Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLEN----VKTKHPQLLYESKIYRILQGG 62 Query: 99 VNFP----FLVKLEYSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIV 152 P F V+ +Y+ +VM+ + P E +F+ R + S A Q++ Sbjct: 63 TGIPNVRWFGVEGDYNV-------LVMDLLGPSLEDLFNFCSR--KLSLKTVLMLADQMI 113 Query: 153 LTFEYLHSLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKGRTW----------TL 199 E++HS ++RD+KP+N L+ + + + DFG AK+ + + L Sbjct: 114 NRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNL 173 Query: 200 CGTPEYLAPEIILSKGYNKAVDWWALG-VLIYEMAAGYP--PFFADQPIQIYEKIVSGKV 256 GT Y + L ++ D +LG VL+Y + P A Q YEKI KV Sbjct: 174 TGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKV 233 Query: 257 R---------FPSHFSS 264 +P+ F+S Sbjct: 234 ATSIEALCRGYPTEFAS 250 >2PVN-A nrPDB Length = 352 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 57/100 (57%), Gaps = 4/100 (4%) Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ-GYIQVTDFGFAKRVK-GRTWTLCGT 202 R+Y +++ +Y HS +++RD+KP N++ID + +++ D+G A+ G+ + + Sbjct: 149 RYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVA 208 Query: 203 PEYL-APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF 240 Y PE+++ + Y+ ++D W+LG + M PFF Sbjct: 209 SRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFF 248 >3AOX-A nrPDB Length = 344 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 101/231 (43%), Gaps = 27/231 (11%) Query: 47 IKTLGTGSFG-----RVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 I+ LG G+FG +V + + + A+K L + V + L E I+ N Sbjct: 52 IRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE--VCSEQDELDFLMEALIISKFNH 109 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHAR------FYAAQIVLT 154 +V+ + ++++E + GG++ S LR R S+P + A I Sbjct: 110 QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACG 169 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQG---YIQVTDFGFAKRV-------KGRTWTLCGTPE 204 +YL I+RD+ N L+ G ++ DFG A+ + KG L + Sbjct: 170 CQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAML--PVK 227 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSG 254 ++ PE + + D W+ GVL++E+ + GY P+ + ++ E + SG Sbjct: 228 WMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG 278 >5VC6-A nrPDB Length = 289 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 58/273 (21%), Positives = 113/273 (41%), Gaps = 47/273 (17%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV--- 99 +F ++ +G+G FG V + G +A+K + K K + +++E+ L+ V Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIK---RSK----KPLAGSVDEQNALREVYAH 64 Query: 100 ----NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL----RRIGRFSEPHARFYAAQI 151 +V+ ++ ++ ++ + EY GG + + R + F E + Q+ Sbjct: 65 AVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQV 124 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQG-------------------YIQVTDFGFAKRV 192 Y+HS+ L++ D+KP N+ I + ++ D G R+ Sbjct: 125 GRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRI 184 Query: 193 KGRTWTLCGTPEYLAPEIILSKGYNK--AVDWWALGVLIYEMAAGYP-PFFADQPIQIYE 249 G +LA E +L + Y D +AL + + A P P DQ + Sbjct: 185 SS-PQVEEGDSRFLANE-VLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQ----WH 238 Query: 250 KIVSGKV-RFPSHFSSDLKDLLRNLLQVDLTKR 281 +I G++ R P S + +LL+ ++ D +R Sbjct: 239 EIRQGRLPRIPQVLSQEFTELLKVMIHPDPERR 271 >3QD2-B nrPDB Length = 332 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 15/102 (14%) Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---------------G 194 QI E+LHS L++RDLKP N+ ++V DFG + Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 231 Query: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGY 236 GT Y++PE I Y+ VD ++LG++++E+ + Sbjct: 232 THTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYSF 273 >5LPZ-A nrPDB Length = 332 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 32/98 (32%), Positives = 50/98 (51%), Gaps = 10/98 (10%) Query: 155 FEYLH---SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTPEYL 206 +LH S +I+RD+K N+L+D+ +V+DFG A+ + TL GTP Y+ Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP 244 PE S + D ++ GV++ E+ G P D P Sbjct: 190 PPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP--TDSP 225 >3UIM-A nrPDB Length = 326 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 92/209 (44%), Gaps = 14/209 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D F LG G FG+V + + G A+K L K++ + +++ + I AV+ Sbjct: 30 DNFSNKNILGRGGFGKVYKGRLAD-GTLVAVKRL-KEERTQGGELQFQTEVEMISMAVHR 87 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT----FEY 157 L + L +V Y+ G + S LR P +I L Y Sbjct: 88 NLLRLRGFCMTPTERL-LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAY 146 Query: 158 LHS---LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR----TWTLCGTPEYLAPEI 210 LH +I+RD+K N+L+D++ V DFG AK + + T + GT ++APE Sbjct: 147 LHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEY 206 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 + + ++ D + GV++ E+ G F Sbjct: 207 LSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >1PY5-A nrPDB Length = 326 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 90/215 (41%), Gaps = 40/215 (18%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 +++G G FG V + K G A+KI ++ E I Q V L Sbjct: 35 ESIGKGRFGEVW--RGKWRGEEVAVKIFSS------REERSWFREAEIYQTVMLRHENIL 86 Query: 108 EYSFKDN------SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 + DN + L++V +Y G +F +L R E + A +LH + Sbjct: 87 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKL-ALSTASGLAHLH-M 144 Query: 162 DLI---------YRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL-------CGTPEY 205 +++ +RDLK +N+L+ + G + D G A R T T+ GT Y Sbjct: 145 EIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY 204 Query: 206 LAPEIILSKGYN-------KAVDWWALGVLIYEMA 233 +APE +L N K D +A+G++ +E+A Sbjct: 205 MAPE-VLDDSINMKHFESFKRADIYAMGLVFWEIA 238 >5LPV-A nrPDB Length = 296 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 32/98 (32%), Positives = 50/98 (51%), Gaps = 10/98 (10%) Query: 155 FEYLH---SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTPEYL 206 +LH S +I+RD+K N+L+D+ +V+DFG A+ + TL GTP Y+ Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP 244 PE S + D ++ GV++ E+ G P D P Sbjct: 190 PPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP--TDSP 225 >3G2F-A nrPDB Length = 336 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 59/244 (24%), Positives = 99/244 (40%), Gaps = 45/244 (18%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI----- 95 LD + ++ +G G +G V +K + + + + KV ++ +NEK I Sbjct: 12 LDNLKLLELIGRGRYGAV----YKGSLDERPVAV----KVFSFANRQNFINEKNIYRVPL 63 Query: 96 LQAVNFP-FLVKLEYSFKDNSNLYM-VMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 ++ N F+V E D Y+ VMEY P G + +L R A + Sbjct: 64 MEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRL-AHSVTR 122 Query: 154 TFEYLHS---------LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR--------- 195 YLH+ + +RDL N+L+ G ++DFG + R+ G Sbjct: 123 GLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEED 182 Query: 196 --TWTLCGTPEYLAPEIILSKGYN--------KAVDWWALGVLIYEMAAGYPPFFADQPI 245 + GT Y+APE +L N K VD +ALG++ +E+ F + + Sbjct: 183 NAAISEVGTIRYMAPE-VLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESV 241 Query: 246 QIYE 249 Y+ Sbjct: 242 PEYQ 245 >4PL5-B nrPDB Length = 435 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/153 (27%), Positives = 75/153 (49%), Gaps = 24/153 (15%) Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLI---DQQGYIQ--VTDFGFAKRVK------GRTWT 198 Q +LHSL++++RDLKP N+L+ + G I+ ++DFG K++ R Sbjct: 129 QTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSG 188 Query: 199 LCGTPEYLAPEIILSKGYNK---AVDWWALG-VLIYEMAAGYPPFFADQPIQIYEKIVSG 254 + GT ++APE++ + VD ++ G V Y ++ GY PF + +Q I+ G Sbjct: 189 VPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF--GKSLQRQANILLG 246 Query: 255 KVRFPSHFSSD------LKDLLRNLLQVDLTKR 281 F SD ++L+ ++ +D +R Sbjct: 247 ACNLDC-FHSDKHEDVIARELIEKMIAMDPQQR 278 >5OAT-A nrPDB Length = 411 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 38/140 (27%), Positives = 65/140 (46%), Gaps = 21/140 (15%) Query: 163 LIYRDLKPENLLID----QQGYIQVTDFG--FAKRVKGRTWTLC-------GTPEYLAPE 209 + +RDLK +NLL+D + + ++DFG A + G + G +APE Sbjct: 174 IAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPE 233 Query: 210 IILSK-------GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF 262 II K Y+KA D WA+G + YE+ + PF+ ++ + + P Sbjct: 234 IICQKPGTFSVLNYSKA-DLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEV 292 Query: 263 SSDLKDLLRNLLQVDLTKRF 282 + ++ L+ NLL+ + KR Sbjct: 293 PTVIQALVANLLKRNPNKRL 312 >5XD6-A nrPDB Length = 305 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 91/215 (42%), Gaps = 22/215 (10%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D + +G GS+GRV K +G A+K LD K + + L + ++ + Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSK----QPDQEFLAQVSMVSRLRQ 76 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFS--HLRRIGRFSEP------HARF-YAAQIV 152 +V L D + EY P G + H R+ + ++P H R A Sbjct: 77 ENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAA 136 Query: 153 LTFEYLH---SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPE 204 EYLH + +I+RD+K N+L+ ++ DF + + + + + GT Sbjct: 137 RGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFG 196 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 Y APE ++ + D ++ GV++ E+ G P Sbjct: 197 YHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPV 231 >6HV0-A nrPDB Length = 416 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 41/152 (26%), Positives = 72/152 (47%), Gaps = 22/152 (14%) Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLI---DQQGYIQ--VTDFGFAKRVK------GRTWT 198 Q +LHSL++++RDLKP N+LI + G I+ ++DFG K++ R Sbjct: 110 QTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSG 169 Query: 199 LCGTPEYLAPEII---LSKGYNKAVDWWALG-VLIYEMAAGYPPFFADQPIQIYEKIVSG 254 + GT ++APE++ + VD ++ G V Y ++ G PF + +Q I+ G Sbjct: 170 VPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF--GKSLQRQANILLG 227 Query: 255 KVRFPS-----HFSSDLKDLLRNLLQVDLTKR 281 H ++L+ ++ +D KR Sbjct: 228 ACSLDCLHPEKHEDVIARELIEKMIAMDPQKR 259 >4XHL-A nrPDB Length = 394 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 101/228 (44%), Gaps = 26/228 (11%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-VNFPFLVK 106 + +G+GSFG + + +G A+++ + + Q+++ R L V PF+ Sbjct: 13 RKIGSGSFGDIYHGTNLISGEEVAIRLESIRS--RHPQLDYESRVYRYLSGGVGIPFIRW 70 Query: 107 LEYSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLI 164 + N+ MV++ + P E +F++ R RFS A Q+ +Y+H I Sbjct: 71 FGREGEYNA---MVIDLLGPSLEDLFNYCHR--RFSFKTVIMLALQMFCRIQYIHGRSFI 125 Query: 165 YRDLKPENLLID---QQGYIQVTDFGFAKRVKG----------RTWTLCGTPEYLAPEII 211 +RD+KP+N L+ + + V DFG +K+ + +L GT Y + Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTH 185 Query: 212 LSKGYNKAVDWWALG-VLIYEMAAGYP--PFFADQPIQIYEKIVSGKV 256 L ++ D +LG VLIY P A Q Y++I+ K+ Sbjct: 186 LGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKL 233 >6BFN-A nrPDB Length = 342 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 88/205 (42%), Gaps = 21/205 (10%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT-LNEKRILQAVNFPFLVKLE 108 +G G FG V + T +A+K L + ++ ++ + L E L P +V Sbjct: 30 IGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFA 87 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL----TFEYLH--SLD 162 N +V ++P G + L + P + I+L ++LH S Sbjct: 88 GYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPS 147 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAK--RVKG----------RTWTLCGTPEYLAPEI 210 LI+ D+K N+L+D++ ++ DFG A+ R G RT T+ GT YL E Sbjct: 148 LIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 207 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAG 235 I + D ++ GV++ E AG Sbjct: 208 IKTGRLAVDTDTFSFGVVVLETLAG 232 >2QKW-B nrPDB Length = 321 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 36/158 (22%), Positives = 69/158 (43%), Gaps = 9/158 (5%) Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT- 154 L P LV L + + + ++ +Y+ G + HL + + +I + Sbjct: 89 LSFCRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGA 148 Query: 155 ---FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-----LCGTPEYL 206 YLH+ +I+RD+K N+L+D+ ++TDFG +K+ T + GT Y+ Sbjct: 149 ARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYI 208 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP 244 PE + + D ++ GV+++E+ P Sbjct: 209 DPEYFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLP 246 >4RT7-A nrPDB Length = 415 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 37/152 (24%), Positives = 76/152 (50%), Gaps = 12/152 (7%) Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT-WTLCGTP-- 203 +A Q+ E+L ++RDL N+L+ +++ DFG A+ + + + + G Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 307 Query: 204 --EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPI--QIYEKIVSG-KVR 257 +++APE + Y D W+ G+L++E+ + G P + P+ Y+ I +G K+ Sbjct: 308 PVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP-YPGIPVDANFYKLIQNGFKMD 366 Query: 258 FPSHFSSDLKDLLRNLLQVDLTKR--FGNLKN 287 P + + ++ ++++ D KR F NL + Sbjct: 367 QPFYATEEIYIIMQSCWAFDSRKRPSFPNLTS 398 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 10/109 (9%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH---KETGNHFAMKILDKQKVVKLKQI 86 KWE P +N E K LG+G+FG+VM +TG + + ++ + Sbjct: 59 KWEFPREN------LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER 112 Query: 87 EHTLNE-KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR 134 E ++E K + Q + +V L + + +Y++ EY G++ ++LR Sbjct: 113 EALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLR 161 >5CLR-A nrPDB Length = 451 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 30/87 (34%), Positives = 45/87 (51%), Gaps = 12/87 (13%) Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFA---KRVKGRTWTLCGTPEYLAPEIILSK- 214 H L LI+RDLKP N+++D + DFG + K K +W GT YLAPE+ + Sbjct: 193 HELGLIHRDLKPGNIMLDADMQCHLVDFGSSSSDKEPKPASW---GTASYLAPELNAQED 249 Query: 215 --GYNKAVDWWALGVLIYEMAAGYPPF 239 +++ D +AL Y + + PF Sbjct: 250 FIAFSQVSDLFALA---YSLDELFNPF 273 >2RIO-A nrPDB Length = 434 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 34/118 (28%), Positives = 57/118 (48%), Gaps = 28/118 (23%) Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLI--------DQQG-----YIQVTDFGFAKRVKGRT 196 QI +LHSL +I+RDLKP+N+L+ DQQ I ++DFG K++ Sbjct: 123 QIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQ 182 Query: 197 WTL-------CGTPEYLAPEII-------LSKGYNKAVDWWALG-VLIYEMAAGYPPF 239 + GT + APE++ + +++D +++G V Y ++ G PF Sbjct: 183 SSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF 240 >4XHH-A nrPDB Length = 403 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/236 (22%), Positives = 105/236 (44%), Gaps = 32/236 (13%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ----A 98 +F + +G+GSFG + + +G A+++ + + Q+++ E R+ + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRS--RHPQLDY---ESRVYKYLSGG 62 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYV-PGGE-MFSHLRRIGRFSEPHARFYAAQIVLTFE 156 V PF+ + N+ MV++ + P E +F++ R +FS A Q++ + Sbjct: 63 VGIPFIRWFGREGEYNA---MVIDLLGPSLEDLFNYCHR--KFSFKTVIMLALQMICRVQ 117 Query: 157 YLHSLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKG----------RTWTLCGTP 203 Y+H I+RD+KP+N L+ + + V DFG +K+ + +L GT Sbjct: 118 YIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTA 177 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP---FFADQPIQIYEKIVSGKV 256 Y + L ++ D +LG ++ G P A Q Y++I+ K+ Sbjct: 178 RYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKL 233 >3REP-A nrPDB Length = 271 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 80/174 (45%), Gaps = 15/174 (8%) Query: 119 MVMEYVPGGEMFSHLRRIGRF--SEPHARFYAAQIVLTFEYLHSLD-LIYRD-LKPENLL 174 ++ ++P G +++ L F + A +A + +LH+L+ LI R L +++ Sbjct: 86 LITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVM 145 Query: 175 IDQQ--GYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYN---KAVDWWALGVLI 229 ID+ I + D F+ + GR + P ++APE + K + ++ D W+ VL+ Sbjct: 146 IDEDMTARISMADVKFSFQSPGRMYA----PAWVAPEALQKKPEDTNRRSADMWSFAVLL 201 Query: 230 YEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSHFSSDLKDLLRNLLQVDLTKR 281 +E+ PF ++I K+ +R P S + L++ + D KR Sbjct: 202 WELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDPAKR 255 >3ZZW-A nrPDB Length = 289 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 58/115 (50%), Gaps = 6/115 (5%) Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTP--- 203 AQI EYL S ++++DL N+L+ + ++++D G + V + L G Sbjct: 134 VAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLP 193 Query: 204 -EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKV 256 ++APE I+ ++ D W+ GV+++E+ + G P+ + E I + +V Sbjct: 194 IRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 248 >4BTK-A nrPDB Length = 337 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 95/214 (44%), Gaps = 22/214 (10%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ +K +G G FG + T + A+K+ Q+ ++ ++E + +K LQ + Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKK--LQGKDH 113 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI---GRFSEPHARFYAAQIVLTFEYL 158 + + ++ Y+VM+ G + LRR G F+ QI+ + E + Sbjct: 114 --VCRFIGCGRNEKFNYVVMQL--QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 169 Query: 159 HSLDLIYRDLKPENLLIDQ--QGY--IQVTDFGFAKRVKGRTWTL---------CGTPEY 205 HS+ ++RD+KP N + + Y + DFG A++ T + GT Y Sbjct: 170 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 229 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 + ++ + D W+L ++ E A G P+ Sbjct: 230 ASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW 263 >4NFN-A nrPDB Length = 309 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 95/214 (44%), Gaps = 22/214 (10%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ +K +G G FG + T + A+K+ Q+ ++ ++E + +K LQ + Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKK--LQGKDH 78 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI---GRFSEPHARFYAAQIVLTFEYL 158 + + ++ Y+VM+ G + LRR G F+ QI+ + E + Sbjct: 79 --VCRFIGCGRNEKFNYVVMQLQ--GRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 134 Query: 159 HSLDLIYRDLKPENLLIDQ--QGY--IQVTDFGFAKRVKGRTWTL---------CGTPEY 205 HS+ ++RD+KP N + + Y + DFG A++ T + GT Y Sbjct: 135 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 194 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 + ++ + D W+L ++ E A G P+ Sbjct: 195 ASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW 228 >3Q4U-A nrPDB Length = 301 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 54/234 (23%), Positives = 98/234 (41%), Gaps = 44/234 (18%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMKIL---DKQKVVKLKQIEHT--LNEKRILQAVNF 101 ++ +G G +G V + G + A+KI D++ + ++ +T L + IL Sbjct: 13 LECVGKGRYGEVW--RGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILG---- 66 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH-- 159 F+ S ++ L+++ Y G ++ +L+ + R + I +LH Sbjct: 67 -FIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLS-IASGLAHLHIE 124 Query: 160 ------SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL-------CGTPEYL 206 + +RDLK +N+L+ + G + D G A T L GT Y+ Sbjct: 125 IFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYM 184 Query: 207 APEI----ILSKGYN--KAVDWWALGVLIYEMAAGY----------PPFFADQP 244 APE+ I ++ K VD WA G++++E+A PPF+ P Sbjct: 185 APEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVP 238 >2WTK-B nrPDB Length = 373 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 44/231 (19%), Positives = 103/231 (44%), Gaps = 21/231 (9%) Query: 44 FERIKTLGTG--SFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 +E + +G G V L ++K TG + ++ ++ + + + E + + N Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSN-EMVTFLQGELHVSKLFNH 69 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGE----MFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 P +V +F ++ L++V ++ G + +H + +E + ++ +Y Sbjct: 70 PNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHF--MDGMNELAIAYILQGVLKALDY 127 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDF--GFAKRVKG-RTWTLCGTPEY-------LA 207 +H + ++R +K ++LI G + ++ + G R + P+Y L+ Sbjct: 128 IHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLS 187 Query: 208 PEIILS--KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV 256 PE++ +GY+ D +++G+ E+A G+ PF Q+ + ++G V Sbjct: 188 PEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTV 238 >4JRN-A nrPDB Length = 372 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 38/150 (25%), Positives = 65/150 (43%), Gaps = 22/150 (14%) Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY 205 + ++Q + + + +++ D+KP N L+ + G + + DFG R+ GTP Y Sbjct: 206 YLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG-TYRINNSVGRAIGTPGY 264 Query: 206 LAPEIILSK---GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF 262 PE Y D W LG+ +Y + P AD I++ + HF Sbjct: 265 EPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPAD---GIWDYL---------HF 312 Query: 263 SSD------LKDLLRNLLQVDLTKRFGNLK 286 + ++DL+R+LL D KR L+ Sbjct: 313 ADCPSTPELVQDLIRSLLNRDPQKRMLPLQ 342 >3MY0-A nrPDB Length = 305 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/217 (23%), Positives = 93/217 (42%), Gaps = 34/217 (15%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL---DKQKVVKLKQIEHTLNEKRILQAV 99 Q ++ +G G +G V + G A+KI D+Q + +I +T+ +L+ Sbjct: 9 QVALVECVGKGRYGEVW--RGLWHGESVAVKIFSSRDEQSWFRETEIYNTV----LLRHD 62 Query: 100 NFPFLVKLEYSFKDNSN-LYMVMEYVPGGEMFSHLRRIGRFSEPH-ARFYAAQIVLTFEY 157 N + + + +++S L+++ Y G ++ L+R + EPH A A + Sbjct: 63 NILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQR--QTLEPHLALRLAVSAACGLAH 120 Query: 158 LH--------SLDLIYRDLKPENLLIDQQGYIQVTDFGFA-KRVKGRTW------TLCGT 202 LH + +RD K N+L+ + D G A +G + GT Sbjct: 121 LHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGT 180 Query: 203 PEYLAPEIILSKGYN------KAVDWWALGVLIYEMA 233 Y+APE++ + K D WA G++++E+A Sbjct: 181 KRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA 217 >3MDY-A nrPDB Length = 337 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 44/215 (20%), Positives = 96/215 (44%), Gaps = 30/215 (13%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL-DKQKVVKLKQIEHTLNEKRILQAVNF 101 Q + +K +G G +G V + K + G A+K+ ++ ++ E + + +++ N Sbjct: 38 QIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETE--IYQTVLMRHENI 93 Query: 102 PFLVKLEYSFKDN-SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 + + + + LY++ +Y G ++ +L+ ++ + A V +LH+ Sbjct: 94 LGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKL-AYSSVSGLCHLHT 152 Query: 161 --------LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT-------WTLCGTPEY 205 + +RDLK +N+L+ + G + D G A + T T GT Y Sbjct: 153 EIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRY 212 Query: 206 LAPEIILSKGYNK-------AVDWWALGVLIYEMA 233 + PE +L + N+ D ++ G++++E+A Sbjct: 213 MPPE-VLDESLNRNHFQSYIMADMYSFGLILWEVA 246 >1CSN-A nrPDB Length = 298 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/140 (27%), Positives = 57/140 (40%), Gaps = 18/140 (12%) Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ-----QGYIQVTDFGFAKRV 192 +FS A Q++ + +H L+YRD+KP+N LI + I V DFG K Sbjct: 102 KFSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFY 161 Query: 193 KGRTW----------TLCGTPEYLAPEIILSKGYNKAVDWWALG-VLIYEMAAGYP--PF 239 + L GT Y++ L + ++ D ALG V +Y + P Sbjct: 162 RDPVTKQHIPYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGL 221 Query: 240 FADQPIQIYEKIVSGKVRFP 259 A Q YE+I K P Sbjct: 222 KAATNKQKYERIGEKKQSTP 241 >4WUA-A nrPDB Length = 401 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 53/257 (20%), Positives = 97/257 (37%), Gaps = 69/257 (26%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV--- 99 ++ I+ LG G F V L + AMK++ + E L+E R+L++V Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAE----HYTETALDEIRLLKSVRNS 97 Query: 100 -----NFPFLVKLEYSFK----DNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYA 148 N +V+L FK + +++ MV E V G + + + P + Sbjct: 98 DPNDPNREMVVQLLDDFKISGVNGTHICMVFE-VLGHHLLKWIIKSNYQGLPLPCVKKII 156 Query: 149 AQIVLTFEYLHS-LDLIYRDLKPENLLID------------------------------- 176 Q++ +YLH+ +I+ D+KPEN+L+ Sbjct: 157 QQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVST 216 Query: 177 ------------------QQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK 218 ++ +++ D G A V T +Y + E+++ GYN Sbjct: 217 APATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNT 276 Query: 219 AVDWWALGVLIYEMAAG 235 D W+ + +E+A G Sbjct: 277 PADIWSTACMAFELATG 293 >3SOC-A nrPDB Length = 322 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 49/100 (49%), Gaps = 12/100 (12%) Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGF-----AKRVKGRTWTLCGTPEYLAPEII-- 211 H + +RD+K +N+L+ + DFG A + G T GT Y+APE++ Sbjct: 148 HKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEG 207 Query: 212 ---LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY 248 + +D +A+G++++E+A+ AD P+ Y Sbjct: 208 AINFQRDAFLRIDMYAMGLVLWELASRCTA--ADGPVDEY 245 >2QLU-A nrPDB Length = 314 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 48/100 (48%), Gaps = 12/100 (12%) Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-----GRTWTLCGTPEYLAPEII-- 211 H + +RD K +N+L+ + DFG A R + G T GT Y+APE++ Sbjct: 140 HKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEG 199 Query: 212 ---LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY 248 + +D +A+G++++E+ + AD P+ Y Sbjct: 200 AINFQRDAFLRIDMYAMGLVLWELVSRCKA--ADGPVDEY 237 >4WOV-A nrPDB Length = 317 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 48/176 (27%), Positives = 73/176 (41%), Gaps = 17/176 (9%) Query: 119 MVMEYVPGGEMFSHLRRIGRFSEPHA--RFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 MV EYV G + LRR R P A A Q+ YL + +L++ ++ N+L+ Sbjct: 133 MVTEYVEHGPLDVWLRR-ERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 191 Query: 177 QQG-------YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK---AVDWWALG 226 + G +I+++D G R + P +LAPE L G N A+D W G Sbjct: 192 RLGLAEGTSPFIKLSDPGVGLGALSREERVERIP-WLAPE-CLPGGANSLSTAMDKWGFG 249 Query: 227 VLIYEMA-AGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + E+ G P + P + E + R P L L L + T+R Sbjct: 250 ATLLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR 304 >5C01-A nrPDB Length = 342 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 48/176 (27%), Positives = 73/176 (41%), Gaps = 17/176 (9%) Query: 119 MVMEYVPGGEMFSHLRRIGRFSEPHA--RFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 MV EYV G + LRR R P A A Q+ YL + +L++ ++ N+L+ Sbjct: 156 MVTEYVEHGPLDVWLRR-ERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 214 Query: 177 QQG-------YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK---AVDWWALG 226 + G +I+++D G R + P +LAPE L G N A+D W G Sbjct: 215 RLGLAEGTSPFIKLSDPGVGLGALSREERVERIP-WLAPE-CLPGGANSLSTAMDKWGFG 272 Query: 227 VLIYEMA-AGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + E+ G P + P + E + R P L L L + T+R Sbjct: 273 ATLLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR 327 >3BYV-A nrPDB Length = 377 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/140 (25%), Positives = 58/140 (41%), Gaps = 11/140 (7%) Query: 143 HARF-YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG 201 HAR Q++ LH L++ L+P ++++DQ+G + +T F R R + Sbjct: 206 HARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGARVVSSVS 265 Query: 202 ----TPEYLAPEIILSKGYNK------AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 251 PE A +S ++ + D WALG++IY + P D + E I Sbjct: 266 RGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEWI 325 Query: 252 VSGKVRFPSHFSSDLKDLLR 271 P + L+ LR Sbjct: 326 FRSCKNIPQPVRALLEGFLR 345 >5E8V-A nrPDB Length = 316 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 46/242 (19%) Query: 50 LGTGSFGRVMLVKHKE-TGNHF---AMKILDKQKVVKLKQIEHTLNEKRILQAVNFP--- 102 +G G F V K K+ T F A+KI ++ K EK I +N Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWK------TEKDIFSDINLKHEN 70 Query: 103 ---FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 FL E + +++ + G + +L R S R + + +LH Sbjct: 71 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTR-HVISWEDLRKLGSSLARGIAHLH 129 Query: 160 S---------LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL--------CGT 202 S + +++RDLK N+L+ + DFG + R+ T ++ GT Sbjct: 130 SDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDP-TLSVDDLANSGQVGT 188 Query: 203 PEYLAPEIILSKGYN-------KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255 Y+APE +L+ N K D +++ ++++EM + A ++ YE K Sbjct: 189 ARYMAPE-VLASAMNLENVESFKQTDVYSMALVLWEMTSRCN---AVGEVKDYEPPFGSK 244 Query: 256 VR 257 VR Sbjct: 245 VR 246 >2X7G-A nrPDB Length = 389 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 53/255 (20%), Positives = 94/255 (36%), Gaps = 67/255 (26%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV--- 99 ++ I+ LG G F V L + AMK++ + E L+E ++L+ V Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQ----HYTETALDEIKLLKCVRES 87 Query: 100 -----NFPFLVKLEYSFK----DNSNLYMVMEYVPGGEMFSHLRRIGRFSEP--HARFYA 148 N +V+L FK + ++ MV E V G + + + P + Sbjct: 88 DPSDPNKDMVVQLIDDFKISGMNGIHVCMVFE-VLGHHLLKWIIKSNYQGLPVRCVKSII 146 Query: 149 AQIVLTFEYLHS-LDLIYRDLKPENLLID-QQGYIQ------------------------ 182 Q++ +YLHS +I+ D+KPEN+L+ Y++ Sbjct: 147 RQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVST 206 Query: 183 ----------------------VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 220 + D G A V T +Y + E+++ GY+ Sbjct: 207 APAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPA 266 Query: 221 DWWALGVLIYEMAAG 235 D W+ + +E+A G Sbjct: 267 DIWSTACMAFELATG 281 >6G4J-A nrPDB Length = 315 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 59/138 (42%), Gaps = 23/138 (16%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 K LG G+ G V L + + H A+K+ D + +E +L++ + V + Sbjct: 32 KQLGKGANGIVYLAETSD--GHVALKVSDDSLSI--------TSEVNVLKSFSKAQSVTM 81 Query: 108 EYSFKDNSNLYM----------VMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 SF D + Y+ MEY+ G + ++ G P Q++ + Sbjct: 82 GPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIP---VLMIQLLSSLSV 138 Query: 158 LHSLDLIYRDLKPENLLI 175 LH I+ DLKP+NL++ Sbjct: 139 LHQQGWIFGDLKPDNLIV 156 >6EQI-C nrPDB Length = 433 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 25/144 (17%) Query: 162 DLIYRDLKPENLLID-QQG----YIQVTDFGFAKRVKGRTWTLC---------GTPEYLA 207 ++ +RDLK +N+L+D +G I +TDFG K + G +A Sbjct: 187 NISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMA 246 Query: 208 PEIILSK-------GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRF 258 PEI +K Y K+ D WA+G + YE+ PF+ D+ +++ K + Sbjct: 247 PEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFNIDNPFY-DKTMKLLSKSYKEEDLPEL 304 Query: 259 PSHFSSDLKDLLRNLLQVDLTKRF 282 P +++L+ N+L KR Sbjct: 305 PDTIPFIIRNLVSNMLSRSTNKRL 328 >5DMZ-A nrPDB Length = 365 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 23/105 (21%), Positives = 50/105 (47%), Gaps = 16/105 (15%) Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLI-----------DQQGYIQVTDFGFAKRV--- 192 +A +++ E +H ++I+ D+KP+N ++ D + + D G + + Sbjct: 177 FAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLF 236 Query: 193 -KGRTWTL-CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAG 235 KG +T C T + E++ +K +N +D++ + +Y M G Sbjct: 237 PKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFG 281 >3DZO-A nrPDB Length = 413 Score = 35.8 bits (81), Expect = 0.025, Method: Compositional matrix adjust. Identities = 35/139 (25%), Positives = 55/139 (39%), Gaps = 10/139 (7%) Query: 143 HARF-YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG 201 HAR Q++ LH L++ L+P ++++DQ+G + +T F R + G Sbjct: 211 HARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGASAVSPIG 270 Query: 202 ---TPEYLAPEIILSKGYNK------AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252 P E +L G + A D W LG+ IY + P D + E I Sbjct: 271 RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIF 330 Query: 253 SGKVRFPSHFSSDLKDLLR 271 P + L+ LR Sbjct: 331 RSCKNIPQPVRALLEGFLR 349 >5X1R-A nrPDB Length = 302 Score = 35.4 bits (80), Expect = 0.035, Method: Compositional matrix adjust. Identities = 38/196 (19%), Positives = 76/196 (38%), Gaps = 32/196 (16%) Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS-HLRRIGRFSEPHARFYA 148 + E R+L + P L+ + +++N YM ++ G + + ++ + E R Sbjct: 87 IQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEAWIRRLL 146 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAP 208 + +H ++RD+ +N+ I + + DFG A++ G Sbjct: 147 PPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDET-------- 198 Query: 209 EIILSKGYNKA--------------VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254 EI+L G+ D +ALG +++ + G PP P+ + I Sbjct: 199 EIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVRSIEDS 253 Query: 255 ----KVRFPSHFSSDL 266 R P+ +S +L Sbjct: 254 YQPLTERRPAGYSPEL 269 >6BHC-A nrPDB Length = 438 Score = 35.0 bits (79), Expect = 0.051, Method: Compositional matrix adjust. Identities = 27/79 (34%), Positives = 39/79 (49%), Gaps = 3/79 (3%) Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP--SHFS 263 LAPEII + Y K D + G+LIYEM PF + ++ E + R P S +S Sbjct: 264 LAPEIITATQYKKC-DEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSPYS 322 Query: 264 SDLKDLLRNLLQVDLTKRF 282 L+ L LL + ++R Sbjct: 323 RGLQQLASCLLNPNPSERI 341 >5UU1-A nrPDB Length = 324 Score = 35.0 bits (79), Expect = 0.051, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 74/163 (45%), Gaps = 22/163 (13%) Query: 48 KTLGTGSFGRVML----------------VKHKETGNHFAMKILDKQKVVKLKQIEHTLN 91 K +G+G FG + L V+++E G F+ ++ Q+V K I+ + Sbjct: 22 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFS-ELKFYQRVAKKDCIKKWI- 79 Query: 92 EKRILQAVNFPFLVKLEYS-FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 E++ L + P + FK S +MVME + G ++ + G F + + Sbjct: 80 ERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKKSTVLQLGIR 138 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV--TDFGFAKR 191 ++ EY+H + ++ D+K NLL+ + QV D+G + R Sbjct: 139 MLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR 181 >3Q60-A nrPDB Length = 371 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 40/94 (42%), Gaps = 4/94 (4%) Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAP 208 AQ++ L S L++ P+NL I G + + D +V G P AP Sbjct: 201 AQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKV-GTRGPASSVPVTYAP 259 Query: 209 EIIL---SKGYNKAVDWWALGVLIYEMAAGYPPF 239 L + + A++ W LG+ IY + + PF Sbjct: 260 REFLNASTATFTHALNAWQLGLSIYRVWCLFLPF 293 >2RSV-A nrPDB Length = 403 Score = 32.3 bits (72), Expect = 0.30, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 2/56 (3%) Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV--TDFGFAKR 191 RFS + +I+ EY+H + ++ D+K NLL++ + QV D+G A R Sbjct: 155 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 210 >2LAV-A nrPDB Length = 361 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 2/56 (3%) Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV--TDFGFAKR 191 RFS + +I+ EY+H + ++ D+K NLL++ + QV D+G A R Sbjct: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 >2W1Z-A nrPDB Length = 368 Score = 32.3 bits (72), Expect = 0.34, Method: Compositional matrix adjust. Identities = 33/139 (23%), Positives = 55/139 (39%), Gaps = 10/139 (7%) Query: 143 HARF-YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG 201 HAR Q++ L L++ D + N+L+DQ+G + +T F R + G Sbjct: 191 HARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGFEHLVRDGASAVSPIG 250 Query: 202 ----TPEYLAPEIILSKGYNKAV-----DWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252 PE A ++ + ++ + D W LG+ IY + P D + E I Sbjct: 251 RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPNTEDAELGGIEWIY 310 Query: 253 SGKVRFPSHFSSDLKDLLR 271 P + L+ LR Sbjct: 311 RRCKNIPQPVRALLEGFLR 329 >3C37-A nrPDB Length = 253 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 25/84 (29%), Positives = 48/84 (57%), Gaps = 13/84 (15%) Query: 55 FGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE--KRIL---QAVNFPFLVKLEY 109 F + + + KE GN FA++I +Q+ V +++ +++ KR+L +AV F ++ K+ Sbjct: 11 FNMISIEQEKELGNKFAVEIEKQQQPVNDPEVQRYVDKVGKRLLSGARAVEFDYVFKV-- 68 Query: 110 SFKDNS-NLYMVMEYVPGGEMFSH 132 KD+S N + +PGG ++ H Sbjct: 69 -VKDDSVNAFA----IPGGRVYVH 87 >6J6I-B nrPDB Length = 351 Score = 32.0 bits (71), Expect = 0.46, Method: Compositional matrix adjust. Identities = 23/101 (22%), Positives = 48/101 (47%), Gaps = 10/101 (9%) Query: 150 QIVLTFEYLHSL---DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRT-----WTLC 200 +I YLH+ +I+RD+KP ++ +D+ +++D F+ + +G++ W L Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVL- 229 Query: 201 GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA 241 GT Y+ P + + D ++ G+ + + G P Sbjct: 230 GTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKPAIMT 270 >4IX6-A nrPDB Length = 350 Score = 31.2 bits (69), Expect = 0.64, Method: Compositional matrix adjust. Identities = 12/42 (28%), Positives = 26/42 (61%), Gaps = 2/42 (4%) Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQ--GYIQVTDFGFA 189 +++ + LH +++RD+KP NL+ ++ G +++ D G A Sbjct: 151 ELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA 192 >2JII-A nrPDB Length = 352 Score = 31.2 bits (69), Expect = 0.66, Method: Compositional matrix adjust. Identities = 24/104 (23%), Positives = 50/104 (48%), Gaps = 12/104 (11%) Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT--DFGFAKR----------VKGR 195 A +++ E+LH + ++ ++ EN+ +D + QVT +GFA R V+G Sbjct: 165 ACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGS 224 Query: 196 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 G E+++ ++ G ++ D +LG + + G+ P+ Sbjct: 225 RSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPW 268 >2Z8G-A nrPDB Length = 549 Score = 31.2 bits (69), Expect = 0.80, Method: Compositional matrix adjust. Identities = 20/104 (19%), Positives = 42/104 (40%), Gaps = 5/104 (4%) Query: 28 LKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIE 87 +K PA ++ + D F + G G ++ + + + VK+ + Sbjct: 42 VKVQTTPASSSLYYDSFVYLAIPGNGMSDQLQYTQGYNQTQAWTSFLYSHDATVKISRNG 101 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 + N +++ + F V+ DN ++Y+ + Y P G FS Sbjct: 102 SSANSNVVIRPTSLNFPVRY-----DNQSVYITVPYSPTGYRFS 140 >5N28-B nrPDB Length = 444 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 20/36 (55%) Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 E A F + +FE LH L L Y+ L +NL+ID Sbjct: 219 EQTAMFEMGDAIGSFERLHLLGLAYQGLNADNLVID 254 >5VE6-A nrPDB Length = 492 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 37/125 (29%), Positives = 53/125 (42%), Gaps = 21/125 (16%) Query: 170 PENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY--------LAPEIILSKGYNKAVD 221 PE Q + +++F AK+ G GTP LAPEI+ + Y K D Sbjct: 287 PEGPREKQLPRLIISNFLKAKQKPG------GTPNLQQKKSQARLAPEIVSASQYRK-FD 339 Query: 222 WWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLRNLLQVD 277 + G+LIYE+ PF Q+ E+ + P S +S L+ L LL+ D Sbjct: 340 EFQTGILIYELLHQPNPFEVR--AQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEAD 397 Query: 278 LTKRF 282 KR Sbjct: 398 PIKRI 402 >5N1Q-B nrPDB Length = 443 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 20/36 (55%) Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 E A F + +FE +H L L Y+ L +NL+ID Sbjct: 219 EQTAMFEMGDAIGSFERMHLLGLAYQGLNSDNLVID 254 >6EWX-A nrPDB Length = 484 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 7/81 (8%) Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SH 261 LAPEI+ + Y K D + G+LIYE+ PF Q+ E+ + P S Sbjct: 317 LAPEIVSASQYRK-FDEFQTGILIYELLHQPNPFEVR--AQLRERDYRREDLPPLPTLSL 373 Query: 262 FSSDLKDLLRNLLQVDLTKRF 282 +S L+ L LL+ D KR Sbjct: 374 YSPGLQQLAHLLLEADPIKRI 394 >4CWM-A nrPDB Length = 269 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 5/73 (6%) Query: 188 FAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 +A +VK W C T + P+I S+G A DW GV + F++ PI + Sbjct: 189 WADQVK--RWETC-TKKTACPDIYASEGIQAACDWAYKGVTEGDTLED-EYFYSRLPI-V 243 Query: 248 YEKIVSGKVRFPS 260 Y+++ G VR + Sbjct: 244 YQRLAQGGVRLAA 256 >5A8R-B nrPDB Length = 443 Score = 28.5 bits (62), Expect = 4.3, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 17/36 (47%) Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 E A F V FE +H L L Y+ L NLL D Sbjct: 219 EQTAMFETGDAVGAFERMHLLGLAYQGLNANNLLFD 254 >3ENH-A nrPDB Length = 540 Score = 28.1 bits (61), Expect = 6.5, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 18/33 (54%), Gaps = 2/33 (6%) Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 190 LH D+I+ DL N + D+ YI DFG K Sbjct: 447 LHKNDVIHNDLTTSNFIFDKDLYI--IDFGLGK 477 >2BMB-A nrPDB Length = 545 Score = 27.7 bits (60), Expect = 8.0, Method: Compositional matrix adjust. Identities = 17/71 (23%), Positives = 32/71 (45%), Gaps = 5/71 (7%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHF-----AMKILDKQKVVKLKQIEHTLNEK 93 +H+ + +G GS+ R L G+ F A+++L ++K VKL+ I + Sbjct: 2 SHMASMTGGQQMGRGSWKRAFLAFGSNIGDRFKHIQMALQLLSREKTVKLRNISSIFESE 61 Query: 94 RILQAVNFPFL 104 + PF+ Sbjct: 62 PMYFKDQTPFM 72 >5VH1-A nrPDB Length = 178 Score = 27.7 bits (60), Expect = 8.7, Method: Compositional matrix adjust. Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 1/61 (1%) Query: 191 RVKGRTWTLCGTPEYLAPEIILSKG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE 249 RV+G TW P Y +L +G Y W L + A + P A IQ++E Sbjct: 41 RVEGGTWVAYERPNYSGNMYVLRRGEYPDYHHWMGLNDRLGSCKAVHIPSGAQGHIQVFE 100 Query: 250 K 250 K Sbjct: 101 K 101 >3II0-A nrPDB Length = 422 Score = 27.3 bits (59), Expect = 8.9, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 45/106 (42%), Gaps = 20/106 (18%) Query: 10 GSEQESVKEFLAKAKEDFLKKWENPAQNTAHL--------DQFE-----------RIKTL 50 G E ES+ + L++ ++ W NP A + + FE RI T+ Sbjct: 263 GKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTM 322 Query: 51 GTGSFGRVMLVKHKETGNHFAMKI-LDKQKVVKLKQIEHTLNEKRI 95 + R+ +K T NH +I + + KQ+E+ +NEK I Sbjct: 323 RSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLVNEKHI 368 >5ZJI-4 nrPDB Length = 252 Score = 27.3 bits (59), Expect = 9.9, Method: Compositional matrix adjust. Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 11/57 (19%) Query: 170 PENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG 226 PENL + Y+Q A+ V GR W + G L PE++ G A W+ G Sbjct: 86 PENL----RWYVQ------AELVNGR-WAMLGVAGMLIPEVLTKAGLINAPQWYDAG 131 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5N23-A nrPDB 499 e-141 4WB7-A nrPDB 483 e-137 5X3F-B nrPDB 483 e-137 1FOT-A nrPDB 375 e-104 5KCV-A nrPDB 347 6e-96 2JDO-A nrPDB 346 6e-96 3MV5-A nrPDB 346 9e-96 3TXO-A nrPDB 341 2e-94 4L42-A nrPDB 341 2e-94 6BDL-A nrPDB 338 2e-93 5D9K-A nrPDB 337 3e-93 3HDN-A nrPDB 337 5e-93 2Z7Q-A nrPDB 336 8e-93 5FET-A nrPDB 332 2e-91 4RA4-A nrPDB 331 2e-91 5F9E-A nrPDB 326 1e-89 4RLP-A nrPDB 325 2e-89 5DYK-A nrPDB 324 4e-89 3PFQ-A nrPDB 322 1e-88 3A8W-A nrPDB 318 2e-87 2I0E-A nrPDB 318 2e-87 1VZO-A nrPDB 318 2e-87 5ES1-A nrPDB 316 8e-87 6E9W-A nrPDB 315 1e-86 4REW-A nrPDB 315 2e-86 5KZ7-A nrPDB 314 3e-86 2QNJ-A nrPDB 313 6e-86 4OTD-A nrPDB 313 8e-86 6ED6-A nrPDB 309 9e-85 4CFH-A nrPDB 309 1e-84 4RED-A nrPDB 309 2e-84 3TKU-A nrPDB 306 1e-83 4AW2-A nrPDB 304 3e-83 4CFF-A nrPDB 304 5e-83 4CRS-A nrPDB 303 6e-83 3HZT-A nrPDB 303 9e-83 5EZV-A nrPDB 302 1e-82 3DXN-A nrPDB 302 1e-82 5JN2-A nrPDB 301 4e-82 4D28-A nrPDB 300 7e-82 4TNB-A nrPDB 299 9e-82 5LOH-A nrPDB 299 1e-81 4CZT-A nrPDB 297 3e-81 5FG8-A nrPDB 297 6e-81 2VN9-A nrPDB 296 1e-80 3C51-A nrPDB 296 1e-80 3ORZ-A nrPDB 296 1e-80 4MVF-A nrPDB 295 2e-80 5IG1-A nrPDB 294 3e-80 3MA6-A nrPDB 294 3e-80 5UUU-A nrPDB 294 6e-80 2V7O-A nrPDB 293 9e-80 3PVW-A nrPDB 292 1e-79 3NYO-A nrPDB 292 2e-79 2BDW-A nrPDB 292 2e-79 2VD5-A nrPDB 292 2e-79 3MN3-A nrPDB 291 2e-79 2JC6-A nrPDB 291 5e-79 4UZD-A nrPDB 290 5e-79 5U6Y-A nrPDB 290 7e-79 3BHH-A nrPDB 289 9e-79 2VZ6-A nrPDB 289 1e-78 2YZA-A nrPDB 289 1e-78 3KK8-A nrPDB 289 2e-78 2HAK-A nrPDB 288 2e-78 5YKS-A nrPDB 288 3e-78 4YZB-A nrPDB 288 3e-78 4RGJ-A nrPDB 287 4e-78 3D2K-A nrPDB 287 4e-78 3NCG-A nrPDB 287 5e-78 6BXI-A nrPDB 287 6e-78 3LIJ-A nrPDB 287 6e-78 4FG9-A nrPDB 287 7e-78 3H4J-B nrPDB 286 1e-77 3DFA-A nrPDB 286 1e-77 6C9D-A nrPDB 286 1e-77 3OHT-A nrPDB 284 3e-77 3SOA-A nrPDB 284 4e-77 3DB8-A nrPDB 283 7e-77 4FR4-A nrPDB 283 7e-77 4D2V-A nrPDB 282 2e-76 4JXF-A nrPDB 282 2e-76 2JAM-A nrPDB 281 2e-76 4CQG-A nrPDB 281 2e-76 3COM-A nrPDB 281 3e-76 5JZN-A nrPDB 281 4e-76 4YHJ-A nrPDB 280 4e-76 5WAX-A nrPDB 278 2e-75 4YNZ-A nrPDB 277 5e-75 4JG6-A nrPDB 276 1e-74 2YAB-A nrPDB 275 2e-74 4NIF-A nrPDB 275 2e-74 6FDY-U nrPDB 274 3e-74 4I6B-A nrPDB 274 5e-74 4CSV-A nrPDB 273 7e-74 4C0T-A nrPDB 273 1e-73 4B8L-A nrPDB 272 1e-73 3Q5I-A nrPDB 272 2e-73 5XZW-A nrPDB 272 2e-73 4B6L-A nrPDB 272 2e-73 3ZUT-A nrPDB 272 2e-73 6FD3-A nrPDB 272 2e-73 2J90-A nrPDB 272 2e-73 3UC3-A nrPDB 271 3e-73 2W4O-A nrPDB 271 4e-73 3GUB-A nrPDB 270 4e-73 4LG4-A nrPDB 270 4e-73 3UDB-A nrPDB 270 7e-73 2A27-A nrPDB 270 8e-73 4AF3-A nrPDB 269 1e-72 3F3Z-A nrPDB 269 1e-72 6AO5-A nrPDB 268 3e-72 2OU7-A nrPDB 267 5e-72 1ZWS-A nrPDB 267 6e-72 2YCR-A nrPDB 266 1e-71 4J52-A nrPDB 265 1e-71 3TAC-A nrPDB 264 4e-71 4FIE-A nrPDB 264 6e-71 4PDS-A nrPDB 264 6e-71 6CMJ-A nrPDB 264 6e-71 3Q53-A nrPDB 263 7e-71 3GC9-A nrPDB 263 9e-71 2Q0N-A nrPDB 263 1e-70 4JDH-A nrPDB 262 1e-70 4EWQ-A nrPDB 262 2e-70 2UV2-A nrPDB 262 2e-70 4XBR-A nrPDB 262 2e-70 3I6U-A nrPDB 262 2e-70 2Y7J-A nrPDB 261 3e-70 2F57-A nrPDB 260 8e-70 4KS7-A nrPDB 259 2e-69 5YV8-A nrPDB 257 5e-69 4QMW-A nrPDB 257 5e-69 2BPM-A nrPDB 257 6e-69 1PHK-A nrPDB 256 8e-69 4APC-A nrPDB 256 9e-69 2WQN-A nrPDB 255 2e-68 5MJB-A nrPDB 255 2e-68 4FZF-B nrPDB 255 3e-68 1CM8-A nrPDB 254 3e-68 6HXF-B nrPDB 254 4e-68 2XYN-A nrPDB 253 1e-67 5J5T-A nrPDB 252 1e-67 2XIK-A nrPDB 252 2e-67 3UTO-A nrPDB 251 3e-67 2FO0-A nrPDB 251 4e-67 4XEY-B nrPDB 251 4e-67 2H8H-A nrPDB 250 5e-67 1JPA-A nrPDB 249 1e-66 1KOA-A nrPDB 249 2e-66 6F3F-A nrPDB 248 2e-66 4P5Q-A nrPDB 248 2e-66 6NPU-A nrPDB 248 2e-66 3IS5-A nrPDB 248 3e-66 3KN6-A nrPDB 248 3e-66 2X4F-A nrPDB 247 5e-66 1K9A-A nrPDB 247 6e-66 4EBW-A nrPDB 246 9e-66 3NIZ-A nrPDB 246 9e-66 2Y6O-A nrPDB 246 9e-66 1BYG-A nrPDB 246 1e-65 4WNO-A nrPDB 245 2e-65 3V5Q-A nrPDB 245 2e-65 4MYG-A nrPDB 244 3e-65 3DAK-A nrPDB 244 4e-65 6GU6-A nrPDB 244 4e-65 3PPZ-A nrPDB 244 5e-65 3DKO-A nrPDB 244 5e-65 3TT0-A nrPDB 244 6e-65 5SYS-A nrPDB 244 6e-65 2VWV-A nrPDB 243 9e-65 5L6P-A nrPDB 243 9e-65 6GQK-A nrPDB 243 1e-64 2DQ7-X nrPDB 243 1e-64 4AT3-A nrPDB 243 1e-64 2HW6-A nrPDB 242 1e-64 1NY3-A nrPDB 242 1e-64 1KOB-A nrPDB 242 2e-64 5A46-A nrPDB 242 2e-64 2R2P-A nrPDB 242 2e-64 2J0K-A nrPDB 242 2e-64 4E93-A nrPDB 242 2e-64 2OZA-A nrPDB 241 3e-64 3A4O-X nrPDB 241 4e-64 3GQL-A nrPDB 241 4e-64 4UY9-A nrPDB 241 4e-64 3ZDU-A nrPDB 240 5e-64 4AGU-A nrPDB 240 5e-64 3FXW-A nrPDB 240 6e-64 3KA0-A nrPDB 240 7e-64 2PSQ-A nrPDB 240 7e-64 5D7A-A nrPDB 240 8e-64 4XLV-A nrPDB 239 1e-63 6CCF-A nrPDB 239 1e-63 5KMM-A nrPDB 239 1e-63 5AMN-A nrPDB 239 1e-63 6CQF-A nrPDB 239 1e-63 3QUP-A nrPDB 239 2e-63 6QAU-A nrPDB 239 2e-63 4AN9-A nrPDB 238 2e-63 4XCU-A nrPDB 238 3e-63 6CKI-A nrPDB 238 3e-63 5H2U-A nrPDB 238 3e-63 3DTC-A nrPDB 237 5e-63 2PL0-A nrPDB 237 5e-63 3BEA-A nrPDB 237 5e-63 5FM2-A nrPDB 237 6e-63 4K33-A nrPDB 237 7e-63 2XNP-A nrPDB 237 8e-63 2OGV-A nrPDB 236 1e-62 3KUL-B nrPDB 236 1e-62 4PDO-A nrPDB 236 1e-62 4BGQ-A nrPDB 235 2e-62 5KKR-C nrPDB 235 3e-62 5DBX-A nrPDB 234 4e-62 4BBM-A nrPDB 234 4e-62 5VO2-A nrPDB 234 5e-62 2HK5-A nrPDB 234 5e-62 3KRL-A nrPDB 233 6e-62 4R7H-A nrPDB 233 8e-62 4KRC-A nrPDB 233 9e-62 5EG3-A nrPDB 232 1e-61 4XUF-A nrPDB 231 3e-61 3HKO-A nrPDB 231 3e-61 3G0E-A nrPDB 231 3e-61 4GS6-A nrPDB 231 3e-61 3LM0-A nrPDB 231 3e-61 1U5R-A nrPDB 231 4e-61 5X02-A nrPDB 230 6e-61 3QGY-A nrPDB 230 7e-61 4H1J-A nrPDB 230 8e-61 5X5O-A nrPDB 230 1e-60 4HZS-A nrPDB 230 1e-60 1AD5-A nrPDB 229 1e-60 2GCD-A nrPDB 229 1e-60 1LUF-A nrPDB 229 1e-60 1U54-B nrPDB 229 1e-60 1FVR-A nrPDB 229 1e-60 6E2O-A nrPDB 228 2e-60 4AU8-A nrPDB 228 4e-60 3CJF-A nrPDB 227 4e-60 3EQC-A nrPDB 227 4e-60 5GRN-A nrPDB 227 5e-60 3SXS-A nrPDB 227 6e-60 4X7Q-B nrPDB 227 7e-60 4IC8-A nrPDB 226 9e-60 5TUR-A nrPDB 226 1e-59 4UYA-A nrPDB 226 1e-59 6FEX-A nrPDB 226 1e-59 1UA2-A nrPDB 226 1e-59 3ORP-A nrPDB 226 1e-59 3E7O-A nrPDB 225 2e-59 3BGP-A nrPDB 225 2e-59 4YFF-A nrPDB 225 2e-59 4QNY-A nrPDB 225 2e-59 6BSD-A nrPDB 225 2e-59 1G3N-A nrPDB 225 2e-59 5AWM-A nrPDB 225 2e-59 3BBT-B nrPDB 225 2e-59 3OZ6-A nrPDB 224 3e-59 1V0B-A nrPDB 224 4e-59 3I81-A nrPDB 224 4e-59 2WTK-C nrPDB 224 5e-59 2F9G-A nrPDB 224 5e-59 4ZSG-A nrPDB 224 5e-59 2BRG-A nrPDB 223 6e-59 2XS0-A nrPDB 223 6e-59 1JNK-A nrPDB 223 7e-59 4U41-A nrPDB 223 7e-59 4XI2-A nrPDB 223 8e-59 5NGU-A nrPDB 223 8e-59 6E4F-A nrPDB 223 9e-59 5U6B-A nrPDB 223 1e-58 4Y93-A nrPDB 222 1e-58 4NST-A nrPDB 222 2e-58 4RC3-A nrPDB 222 2e-58 1U59-A nrPDB 222 2e-58 3ZBF-A nrPDB 222 3e-58 6DBM-A nrPDB 222 3e-58 5EFQ-A nrPDB 221 3e-58 2OZO-A nrPDB 221 3e-58 6DTL-A nrPDB 221 3e-58 5O2B-A nrPDB 221 4e-58 3GC0-A nrPDB 220 6e-58 4OLI-A nrPDB 220 6e-58 5O2C-A nrPDB 220 9e-58 3PP0-A nrPDB 220 1e-57 3LZB-A nrPDB 219 1e-57 5G6V-A nrPDB 219 1e-57 3DLS-A nrPDB 219 1e-57 4QTB-A nrPDB 219 2e-57 3PLS-A nrPDB 219 2e-57 3FI2-A nrPDB 218 3e-57 5GNK-A nrPDB 217 5e-57 4EQM-A nrPDB 217 5e-57 5Z33-A nrPDB 217 7e-57 5HLW-A nrPDB 217 8e-57 6DBN-A nrPDB 216 1e-56 5HI2-A nrPDB 216 1e-56 4PWN-A nrPDB 215 2e-56 5U6C-A nrPDB 215 3e-56 3M42-A nrPDB 215 3e-56 4X3F-A nrPDB 214 4e-56 4OW8-A nrPDB 214 4e-56 3VN9-A nrPDB 214 4e-56 5HIE-A nrPDB 214 4e-56 4O2Z-A nrPDB 214 4e-56 3C1X-A nrPDB 214 4e-56 6B2Q-A nrPDB 214 4e-56 4FL3-A nrPDB 213 7e-56 2W1I-A nrPDB 213 9e-56 1TKI-A nrPDB 213 1e-55 3ALO-A nrPDB 213 1e-55 3IO7-A nrPDB 213 1e-55 4E20-A nrPDB 212 1e-55 3MIA-A nrPDB 212 2e-55 1S9I-A nrPDB 212 2e-55 5AIR-A nrPDB 212 2e-55 3FME-A nrPDB 212 2e-55 4LRM-A nrPDB 212 3e-55 3AOX-A nrPDB 210 6e-55 1ZXE-A nrPDB 209 1e-54 4HVI-A nrPDB 209 2e-54 2W96-B nrPDB 208 2e-54 3QA8-A nrPDB 208 2e-54 4KIK-B nrPDB 208 3e-54 6FER-A nrPDB 207 4e-54 5C26-A nrPDB 206 1e-53 5Y86-A nrPDB 206 1e-53 5VD3-A nrPDB 205 2e-53 5TQX-A nrPDB 205 2e-53 3OMV-A nrPDB 205 3e-53 5WNO-A nrPDB 205 3e-53 2I6L-A nrPDB 205 3e-53 4TPT-A nrPDB 203 9e-53 4E7W-A nrPDB 203 9e-53 5HVK-A nrPDB 203 1e-52 6GVJ-A nrPDB 202 2e-52 5B2L-A nrPDB 202 3e-52 5ZTN-A nrPDB 201 3e-52 4F0G-A nrPDB 199 1e-51 3E3P-A nrPDB 199 1e-51 3HMP-A nrPDB 197 5e-51 5O0Y-A nrPDB 197 5e-51 3RP9-A nrPDB 197 7e-51 5X8I-B nrPDB 196 2e-50 5AP3-A nrPDB 195 2e-50 2WO6-A nrPDB 195 2e-50 3N9X-A nrPDB 195 2e-50 2ZMD-A nrPDB 195 3e-50 4M7I-A nrPDB 195 3e-50 4IDT-A nrPDB 194 4e-50 4NEU-A nrPDB 193 1e-49 3ZZW-A nrPDB 192 2e-49 3LMG-A nrPDB 192 3e-49 3NIE-A nrPDB 191 3e-49 6CTH-A nrPDB 191 3e-49 4Y83-A nrPDB 191 3e-49 3PG1-A nrPDB 191 5e-49 5UIU-A nrPDB 190 6e-49 6FYV-A nrPDB 189 1e-48 2A1A-B nrPDB 189 2e-48 3EB0-A nrPDB 188 4e-48 4C59-A nrPDB 188 4e-48 5TOS-A nrPDB 185 3e-47 4G3E-A nrPDB 184 4e-47 3UIU-A nrPDB 184 4e-47 6J5U-C nrPDB 183 1e-46 2WTK-B nrPDB 182 2e-46 4LQP-A nrPDB 182 2e-46 2CHL-A nrPDB 181 3e-46 2H34-A nrPDB 180 6e-46 4JLC-A nrPDB 180 6e-46 4EUU-A nrPDB 180 1e-45 5WNL-A nrPDB 179 2e-45 4EUT-A nrPDB 178 2e-45 5UNP-A nrPDB 178 2e-45 5TE0-A nrPDB 177 5e-45 5LPZ-A nrPDB 176 8e-45 3HNG-A nrPDB 176 9e-45 5LPV-A nrPDB 176 1e-44 6NT9-A nrPDB 176 2e-44 6O8B-A nrPDB 175 2e-44 2Y4I-B nrPDB 175 2e-44 2BUJ-A nrPDB 174 6e-44 6O6Q-A nrPDB 174 7e-44 5VC6-A nrPDB 173 7e-44 2PMN-X nrPDB 173 8e-44 5AR8-A nrPDB 173 1e-43 3Q4U-A nrPDB 173 1e-43 3RAW-A nrPDB 173 1e-43 5IKW-A nrPDB 172 2e-43 5CEK-A nrPDB 171 4e-43 6DC0-A nrPDB 171 4e-43 5FQD-C nrPDB 171 5e-43 3UIM-A nrPDB 170 6e-43 5XD6-A nrPDB 170 1e-42 3MY0-A nrPDB 169 2e-42 4TN6-A nrPDB 168 2e-42 3MDY-A nrPDB 168 3e-42 3SV0-A nrPDB 168 3e-42 2CMW-A nrPDB 167 6e-42 5VDK-A nrPDB 167 7e-42 6BFN-A nrPDB 166 9e-42 4MD7-E nrPDB 165 3e-41 2JD5-A nrPDB 165 3e-41 4M66-A nrPDB 165 3e-41 1PY5-A nrPDB 165 4e-41 2RIO-A nrPDB 164 5e-41 2C47-A nrPDB 164 6e-41 6HMD-A nrPDB 163 7e-41 2QKW-B nrPDB 163 1e-40 4PL5-B nrPDB 162 3e-40 4CRL-A nrPDB 161 4e-40 3VHK-A nrPDB 161 6e-40 6HV0-A nrPDB 160 6e-40 3LLT-A nrPDB 160 7e-40 2PVN-A nrPDB 160 1e-39 5XVU-A nrPDB 159 1e-39 5L2Q-C nrPDB 159 2e-39 6EII-A nrPDB 158 2e-39 3REP-A nrPDB 156 9e-39 4NT4-A nrPDB 156 1e-38 4IAN-A nrPDB 155 3e-38 3G2F-A nrPDB 154 6e-38 3QD2-B nrPDB 153 1e-37 1CSN-A nrPDB 152 2e-37 5X18-A nrPDB 151 3e-37 4WUA-A nrPDB 151 3e-37 5M07-A nrPDB 150 9e-37 4XHH-A nrPDB 150 9e-37 4BTK-A nrPDB 149 2e-36 4NFN-A nrPDB 148 4e-36 4RT7-A nrPDB 148 5e-36 4L00-A nrPDB 147 8e-36 4LFI-A nrPDB 145 2e-35 4XHL-A nrPDB 145 3e-35 4F9B-A nrPDB 142 2e-34 3SOC-A nrPDB 142 3e-34 2PZI-A nrPDB 135 3e-32 4WOV-A nrPDB 135 3e-32 4Y12-A nrPDB 135 3e-32 2QLU-A nrPDB 133 1e-31 4JRN-A nrPDB 129 1e-30 5OAT-A nrPDB 123 9e-29 5CLR-A nrPDB 93 2e-19 Sequences not found previously or not previously below threshold: 5E8V-A nrPDB 150 1e-36 2X7G-A nrPDB 147 6e-36 4M69-B nrPDB 145 4e-35 4BTF-A nrPDB 144 5e-35 4MWI-A nrPDB 137 9e-33 5USZ-A nrPDB 136 1e-32 5C01-A nrPDB 136 1e-32 5X1R-A nrPDB 131 5e-31 5J0A-A nrPDB 124 6e-29 4I94-A nrPDB 109 2e-24 6EQI-C nrPDB 106 2e-23 5UV4-A nrPDB 104 4e-23 4L68-A nrPDB 101 4e-22 6J6I-B nrPDB 100 9e-22 5UU1-A nrPDB 98 4e-21 2RSV-A nrPDB 90 1e-18 2LAV-A nrPDB 90 2e-18 6EAS-A nrPDB 81 6e-16 6G4J-A nrPDB 79 2e-15 4O1O-A nrPDB 78 8e-15 5DMZ-A nrPDB 77 1e-14 6BHC-A nrPDB 74 1e-13 6EWX-A nrPDB 70 2e-12 4IX6-A nrPDB 70 2e-12 4OAU-C nrPDB 67 1e-11 6M7Z-A nrPDB 66 2e-11 2JII-A nrPDB 65 6e-11 4CI6-B nrPDB 63 2e-10 5GZ9-A nrPDB 61 6e-10 5GZA-A nrPDB 60 2e-09 3BYV-A nrPDB 57 1e-08 3DZO-A nrPDB 56 3e-08 2W1Z-A nrPDB 55 5e-08 4CZY-B nrPDB 55 6e-08 6G38-A nrPDB 54 9e-08 4AZV-A nrPDB 54 1e-07 4AZW-A nrPDB 54 1e-07 4CYJ-A nrPDB 53 2e-07 5VE6-A nrPDB 50 2e-06 4WWA-A nrPDB 49 3e-06 3Q60-A nrPDB 48 8e-06 5YK0-A nrPDB 47 1e-05 3ENH-A nrPDB 47 1e-05 4BWP-A nrPDB 45 6e-05 1TQM-A nrPDB 40 0.002 6G18-v nrPDB 38 0.008 6FDN-A nrPDB 37 0.013 4BVU-A nrPDB 36 0.022 6G5I-z nrPDB 33 0.21 4OTP-A nrPDB 33 0.22 3LV4-A nrPDB 32 0.52 2X8T-A nrPDB 31 0.67 4GYG-A nrPDB 31 0.76 4IFQ-A nrPDB 31 0.88 >5N23-A nrPDB Length = 352 Score = 499 bits (1284), Expect = e-141, Method: Composition-based stats. Identities = 342/352 (97%), Positives = 348/352 (98%), Gaps = 1/352 (0%) Query: 1 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML 60 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWE+PAQNTAHLDQFERI+TLGTGSFGRVML Sbjct: 1 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVML 60 Query: 61 VKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMV 120 VKHKETGNH+AMKILDKQKVVKLKQIEHTLNEKRI QAVNFPFLVKLE+SFKDNSNLYMV Sbjct: 61 VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMV 120 Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 +EY PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY Sbjct: 121 LEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 Query: 181 IQVTDFGFAKRVKGRT-WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 I+V DFGFAKRVKGRT WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF Sbjct: 181 IKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 240 Query: 240 FADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 FADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA Sbjct: 241 FADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 300 Query: 300 TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351 TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF Sbjct: 301 TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 352 >4WB7-A nrPDB Length = 405 Score = 483 bits (1245), Expect = e-137, Method: Composition-based stats. Identities = 334/338 (98%), Positives = 337/338 (99%) Query: 14 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK 73 E VKEFLAKAKEDFLKKWE+PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH+AMK Sbjct: 68 EEVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMK 127 Query: 74 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL 133 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE+SFKDNSNLYMVMEYVPGGEMFSHL Sbjct: 128 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHL 187 Query: 134 RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK 193 RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK Sbjct: 188 RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK 247 Query: 194 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS Sbjct: 248 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 307 Query: 254 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA Sbjct: 308 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 367 Query: 314 PFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351 PFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF Sbjct: 368 PFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 405 >5X3F-B nrPDB Length = 393 Score = 483 bits (1244), Expect = e-137, Method: Composition-based stats. Identities = 325/336 (96%), Positives = 332/336 (98%) Query: 16 VKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL 75 V+ FLAKAKEDFLKKWE P+QNTA LDQF+RIKTLGTGSFGRVMLVKHKE+GNH+AMKIL Sbjct: 58 VQAFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKIL 117 Query: 76 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR 135 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE+SFKDNSNLYMVMEYV GGEMFSHLRR Sbjct: 118 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRR 177 Query: 136 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR 195 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR Sbjct: 178 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR 237 Query: 196 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK Sbjct: 238 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 297 Query: 256 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPF 315 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPF Sbjct: 298 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPF 357 Query: 316 IPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351 IPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEF+EF Sbjct: 358 IPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 393 >1FOT-A nrPDB Length = 318 Score = 375 bits (964), Expect = e-104, Method: Composition-based stats. Identities = 153/301 (50%), Positives = 221/301 (73%), Gaps = 1/301 (0%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 L F+ ++TLGTGSFGRV L++ + G ++AMK+L K+ VV+LKQ+EHT +E+ +L V Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVT 64 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 PF++++ +F+D ++M+M+Y+ GGE+FS LR+ RF P A+FYAA++ L EYLHS Sbjct: 65 HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHS 124 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 220 D+IYRDLKPEN+L+D+ G+I++TDFGFAK V T+TLCGTP+Y+APE++ +K YNK++ Sbjct: 125 KDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSI 184 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 280 DWW+ G+LIYEM AGY PF+ ++ YEKI++ ++RFP F+ D+KDLL L+ DL++ Sbjct: 185 DWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQ 244 Query: 281 RFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKF-KGPGDTSNFDDYEEEEIRVS 339 R GNL+NG D+KNH WF W + R +E P+ P +G GDTS FD Y EE+I Sbjct: 245 RLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEEDINYG 304 Query: 340 I 340 + Sbjct: 305 V 305 >5KCV-A nrPDB Length = 460 Score = 347 bits (890), Expect = 6e-96, Method: Composition-based stats. Identities = 132/299 (44%), Positives = 188/299 (62%), Gaps = 4/299 (1%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 ++ +++FE +K LG G+FG+V+LVK K TG ++AMKIL K+ +V ++ HTL E R+ Sbjct: 156 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 215 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 LQ PFL L+YSF+ + L VMEY GGE+F HL R FSE ARFY A+IV Sbjct: 216 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 275 Query: 156 EYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR-VKG--RTWTLCGTPEYLAPEII 211 +YLHS +++YRDLK ENL++D+ G+I++TDFG K +K T CGTPEYLAPE++ Sbjct: 276 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 335 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 Y +AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL Sbjct: 336 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 395 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 LL+ D +R G +I H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 396 GLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 454 >2JDO-A nrPDB Length = 342 Score = 346 bits (889), Expect = 6e-96, Method: Composition-based stats. Identities = 127/312 (40%), Positives = 192/312 (61%), Gaps = 4/312 (1%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 ++ F+ +K LG G+FG+V+LV+ K TG ++AMKIL K+ ++ ++ HT+ E R+ Sbjct: 4 DPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRV 63 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 LQ PFL L+Y+F+ + L VMEY GGE+F HL R F+E ARFY A+IV Sbjct: 64 LQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---TWTLCGTPEYLAPEIIL 212 EYLHS D++YRD+K ENL++D+ G+I++TDFG K T CGTPEYLAPE++ Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 Y +AVDWW LGV++YEM G PF+ +++E I+ ++RFP S + K LL Sbjct: 184 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAG 243 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD-Y 331 LL+ D +R G + ++ H++F + +W + Q+K+ PF P+ DT FDD + Sbjct: 244 LLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 303 Query: 332 EEEEIRVSINEK 343 + I ++ ++ Sbjct: 304 TAQSITITPPDR 315 >3MV5-A nrPDB Length = 342 Score = 346 bits (888), Expect = 9e-96, Method: Composition-based stats. Identities = 132/299 (44%), Positives = 186/299 (62%), Gaps = 4/299 (1%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 +++FE +K LG G+FG+V+LVK K TG ++AMKIL K+ +V ++ HTL E R+ Sbjct: 4 DPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 63 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 LQ PFL L+YSF+ + L VMEY GGE+F HL R FSE ARFY A+IV Sbjct: 64 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 123 Query: 156 EYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR-VKG--RTWTLCGTPEYLAPEII 211 +YLHS +++YRDLK ENL++D+ G+I++TDFG K +K T CGTPEYLAPE++ Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 Y +AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL Sbjct: 184 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 243 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 LL+ D +R G +I H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 244 GLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 302 >3TXO-A nrPDB Length = 353 Score = 341 bits (876), Expect = 2e-94, Method: Composition-based stats. Identities = 128/315 (40%), Positives = 190/315 (60%), Gaps = 7/315 (2%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + N +D FE I+ LG GSFG+VML + KETG+ +A+K+L K +++ +E T+ EKR Sbjct: 16 SSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKR 75 Query: 95 ILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 IL N PFL +L F+ L+ VME+V GG++ H+++ RF E ARFYAA+I+ Sbjct: 76 ILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 135 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEI 210 +LH +IYRDLK +N+L+D +G+ ++ DFG K T T CGTP+Y+APEI Sbjct: 136 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 195 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 270 + Y AVDWWA+GVL+YEM G+ PF A+ ++E I++ +V +P+ D +L Sbjct: 196 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGIL 255 Query: 271 RNLLQVDLTKRFGNLKNGVND-IKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 329 ++ + + T R G+L G I H +F DW + R++E PF P+ K D SNFD Sbjct: 256 KSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFD 315 Query: 330 D--YEEEEIRVSINE 342 +EE + I+E Sbjct: 316 PDFIKEEPVLTPIDE 330 >4L42-A nrPDB Length = 346 Score = 341 bits (875), Expect = 2e-94, Method: Composition-based stats. Identities = 120/321 (37%), Positives = 182/321 (56%), Gaps = 8/321 (2%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHK---ETGNHFAMKILDKQKVVK-LKQIEHTL 90 + FE ++ LG G +G+V V+ TG FAMK+L K +V+ K HT Sbjct: 11 GPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTK 70 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 E+ IL+ V PF+V L Y+F+ LY+++EY+ GGE+F L R G F E A FY A+ Sbjct: 71 AERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAE 130 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---TWTLCGTPEYLA 207 I + +LH +IYRDLKPEN++++ QG++++TDFG K T T CGT EY+A Sbjct: 131 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 190 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 267 PEI++ G+N+AVDWW+LG L+Y+M G PPF + + +KI+ K+ P + + + + Sbjct: 191 PEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEAR 250 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN 327 DLL+ LL+ + R G +++ H +F +W + RKVE PF P + D S Sbjct: 251 DLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQ 310 Query: 328 FDD-YEEEEIRVSINEKCGKE 347 FD + + S ++ E Sbjct: 311 FDSKFTRQTPVDSPDDSTLSE 331 >6BDL-A nrPDB Length = 347 Score = 338 bits (867), Expect = 2e-93, Method: Composition-based stats. Identities = 140/312 (44%), Positives = 199/312 (63%), Gaps = 5/312 (1%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHK-ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 L F I TLG G FGRV LV+ K E FAMKIL K+ +V +Q EH +EK+I+Q Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 90 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 + F+V+L +FKD+ LYM+ME GGE+++ LR G F + RFY A +V F Y Sbjct: 91 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 150 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSKG 215 LHS +IYRDLKPENL++D +GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+KG Sbjct: 151 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKG 210 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNL 273 ++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP + + +L++ L Sbjct: 211 HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKL 270 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333 + + ++R GNLKNGV DI+ HKWF +W + + + P IP P DTSNFD + E Sbjct: 271 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE 330 Query: 334 EEIRVSINEKCG 345 + ++ G Sbjct: 331 DNDEPPPDDNSG 342 >5D9K-A nrPDB Length = 330 Score = 337 bits (866), Expect = 3e-93, Method: Composition-based stats. Identities = 116/294 (39%), Positives = 182/294 (61%), Gaps = 7/294 (2%) Query: 43 QFERIKTLGTGSFGRVMLVKHK---ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 QFE +K LG GSFG+V LVK + +AMK+L K + K++ T E+ IL V Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL-KVRDRVRTKMERDILVEV 89 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 N PF+VKL Y+F+ LY++++++ GG++F+ L + F+E +FY A++ L ++LH Sbjct: 90 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 149 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGY 216 SL +IYRDLKPEN+L+D++G+I++TDFG +K + + ++ CGT EY+APE++ +G+ Sbjct: 150 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGH 209 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 ++ DWW+ GVL++EM G PF + I+ K+ P S + + LLR L + Sbjct: 210 TQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKR 269 Query: 277 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 + R G +GV +IK H +F+T DW +Y+R++ PF P P DT FD Sbjct: 270 NPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 323 >3HDN-A nrPDB Length = 373 Score = 337 bits (864), Expect = 5e-93, Method: Composition-based stats. Identities = 129/311 (41%), Positives = 197/311 (63%), Gaps = 6/311 (1%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + A F +K +G GSFG+V+L +HK +A+K+L K+ ++K K+ +H ++E+ Sbjct: 31 SNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERN 90 Query: 95 IL-QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 +L + V PFLV L +SF+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I Sbjct: 91 VLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIAS 150 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAPEI 210 YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAPE+ Sbjct: 151 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV 210 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 270 + + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ + LL Sbjct: 211 LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLL 270 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD- 329 LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P GP D +FD Sbjct: 271 EGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 329 Query: 330 DYEEEEIRVSI 340 ++ EE + +I Sbjct: 330 EFTEEPVPNAI 340 >2Z7Q-A nrPDB Length = 321 Score = 336 bits (862), Expect = 8e-93, Method: Composition-based stats. Identities = 113/294 (38%), Positives = 186/294 (63%), Gaps = 7/294 (2%) Query: 43 QFERIKTLGTGSFGRVMLVKHK---ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 FE +K LG GSFG+V LV+ ++G+ +AMK+L K + K++ T E+ IL V Sbjct: 29 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL-KVRDRVRTKMERDILADV 87 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 N PF+VKL Y+F+ LY++++++ GG++F+ L + F+E +FY A++ L ++LH Sbjct: 88 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 147 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGY 216 SL +IYRDLKPEN+L+D++G+I++TDFG +K + + ++ CGT EY+APE++ +G+ Sbjct: 148 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 207 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 + + DWW+ GVL++EM G PF + I+ K+ P S++ + LLR L + Sbjct: 208 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 267 Query: 277 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 + R G+ +G +IK H +++T DW +Y+R+++ PF P P DT FD Sbjct: 268 NPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 321 >5FET-A nrPDB Length = 847 Score = 332 bits (851), Expect = 2e-91, Method: Composition-based stats. Identities = 118/307 (38%), Positives = 183/307 (59%), Gaps = 3/307 (0%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 + + E + +G G+FG V LV HK T +A+K + K+ ++ L Q + E+ I Sbjct: 527 DTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREI 586 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 + PF+++L +FKD++ Y + E V GGE++ +R++G S+P A+FY I+L Sbjct: 587 TAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAI 646 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG 215 EYLH +++YRDLKPEN+L+D+QGY+++ DFG AK+++GR +TL GTP Y+APE+IL KG Sbjct: 647 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGKG 706 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQP--IQIYEKIVSGKVRFPSHFSS-DLKDLLRN 272 Y VD WALGV +YE G PF DQ ++I+ I++G++ FP + S D +L++ Sbjct: 707 YGCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLMKR 766 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 332 LL R G NG DIK H +F +W + R +E P + K + + + E Sbjct: 767 LLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQIE 826 Query: 333 EEEIRVS 339 EE+ Sbjct: 827 EEDALNE 833 >4RA4-A nrPDB Length = 355 Score = 331 bits (850), Expect = 2e-91, Method: Composition-based stats. Identities = 121/299 (40%), Positives = 179/299 (59%), Gaps = 5/299 (1%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 + L F + LG GSFG+VML K T +A+KIL K V++ +E T+ EKR+L Sbjct: 15 DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVL 74 Query: 97 QAVNFP-FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 ++ P FL +L F+ LY VMEYV GG++ H++++G+F EP A FYAA+I + Sbjct: 75 ALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGL 134 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEIIL 212 +LH +IYRDLK +N+++D +G+I++ DFG K + G T T CGTP+Y+APEII Sbjct: 135 FFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 194 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 + Y K+VDWWA GVL+YEM AG PPF + ++++ I+ V +P S + + + Sbjct: 195 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKG 254 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331 L+ KR G G D++ H +F DW + R+++ PF PK G G NFD + Sbjct: 255 LMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKG-AENFDKF 312 >5F9E-A nrPDB Length = 353 Score = 326 bits (835), Expect = 1e-89, Method: Composition-based stats. Identities = 121/318 (38%), Positives = 183/318 (57%), Gaps = 10/318 (3%) Query: 32 ENPA-QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 E P+ Q ++ FE K LG GSFG+V L + K+T FA+K L K V+ +E T+ Sbjct: 8 ERPSLQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTM 67 Query: 91 NEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149 EKR+L PFL + +F+ NL+ VMEY+ GG++ H++ +F A FYAA Sbjct: 68 VEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAA 127 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYL 206 +I+L ++LHS ++YRDLK +N+L+D+ G+I++ DFG K +T CGTP+Y+ Sbjct: 128 EIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYI 187 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL 266 APEI+L + YN +VDWW+ GVL+YEM G PF +++ I +P + Sbjct: 188 APEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEA 247 Query: 267 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTS 326 KDLL L + KR G DI+ H F +W + +++++ PF PK K P D S Sbjct: 248 KDLLVKLFVREPEKRLGVR----GDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCS 303 Query: 327 NFD-DYEEEEIRVSINEK 343 NFD ++ E+ R+S ++ Sbjct: 304 NFDKEFLNEKPRLSFADR 321 >4RLP-A nrPDB Length = 288 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 114/283 (40%), Positives = 171/283 (60%), Gaps = 7/283 (2%) Query: 42 DQFERIKTLGTGSFGRVMLVKHK---ETGNHFAMKILDKQKVVK-LKQIEHTLNEKRILQ 97 + FE ++ LG G +G+V V+ TG FAMK+L K +V+ K HT E+ IL+ Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 V PF+V L Y+F+ LY+++EY+ GGE+F L R G F E A FY A+I + + Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 124 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---TWTLCGTPEYLAPEIILSK 214 LH +IYRDLKPEN++++ QG++++TDFG K T T CGT EY+APEI++ Sbjct: 125 LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 184 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLL 274 G+N+AVDWW+LG L+Y+M G PPF + + +KI+ K+ P + + + +DLL+ LL Sbjct: 185 GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLL 244 Query: 275 QVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 317 + + R G +++ H +F +W + RKVE PF P Sbjct: 245 KRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >5DYK-A nrPDB Length = 853 Score = 324 bits (830), Expect = 4e-89, Method: Composition-based stats. Identities = 112/299 (37%), Positives = 179/299 (59%), Gaps = 3/299 (1%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 +D+ E + +G G+FG V LV HK T +A+K + K+ ++ L Q + E+ I Sbjct: 533 DTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREI 592 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 + PF+++L +FKD+ Y + E V GGE++ +R++G S+ A+FY I+L Sbjct: 593 TAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAI 652 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG 215 EYLH +++YRDLKPEN+L+D+QGY+++ DFG AK+V+GR +TL GTP Y+APE+IL KG Sbjct: 653 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKG 712 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFAD--QPIQIYEKIVSGKVRFPSHFSS-DLKDLLRN 272 Y VD WALG+ +YE G PF D ++I+ I++G++ FP + + D +L++ Sbjct: 713 YGCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKR 772 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331 LL R G NG DIK+H +F+ +W + R ++ P + K + + + Sbjct: 773 LLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDIDIKQI 831 >3PFQ-A nrPDB Length = 674 Score = 322 bits (826), Expect = 1e-88, Method: Composition-based stats. Identities = 120/315 (38%), Positives = 181/315 (57%), Gaps = 7/315 (2%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 ++ L F + LG GSFG+VML + K T +A+KIL K V++ +E T+ EKR+ Sbjct: 335 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 394 Query: 96 LQA-VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 L PFL +L F+ LY VMEYV GG++ H++++GRF EPHA FYAA+I + Sbjct: 395 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 454 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEII 211 +L S +IYRDLK +N+++D +G+I++ DFG K T T CGTP+Y+APEII Sbjct: 455 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 514 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 + Y K+VDWWA GVL+YEM AG PF + ++++ I+ V +P S + + + Sbjct: 515 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 574 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331 L+ KR G G DIK H +F DW + +++++ P+ PK G NFD + Sbjct: 575 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRN-AENFDRF 633 Query: 332 --EEEEIRVSINEKC 344 + +++ Sbjct: 634 FTRHPPVLTPPDQEV 648 >3A8W-A nrPDB Length = 345 Score = 318 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 121/323 (37%), Positives = 186/323 (57%), Gaps = 15/323 (4%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 A + L F+ ++ +G GS+ +V+LV+ K+T +AMK++ K+ V + I+ EK Sbjct: 2 AMDPLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKH 61 Query: 95 IL-QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 + QA N PFLV L F+ S L+ V+EYV GG++ H++R + E HARFY+A+I L Sbjct: 62 VFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISL 121 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAPEI 210 YLH +IYRDLK +N+L+D +G+I++TD+G K R T T CGTP Y+APEI Sbjct: 122 ALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEI 181 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQ-----IYEKIVSGKVRFPSH 261 + + Y +VDWWALGVL++EM AG PF +D P Q +++ I+ ++R P Sbjct: 182 LRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRS 241 Query: 262 FSSDLKDLLRNLLQVDLTKRFGNLKNG-VNDIKNHKWFATTDWIAIYQRKVEAPFIPKFK 320 S +L++ L D +R G DI+ H +F DW + Q++V PF P Sbjct: 242 LSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNIS 301 Query: 321 GPGDTSNFDD-YEEEEIRVSINE 342 G NFD + E ++++ ++ Sbjct: 302 GEFGLDNFDSQFTNEPVQLTPDD 324 >2I0E-A nrPDB Length = 353 Score = 318 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 120/315 (38%), Positives = 181/315 (57%), Gaps = 7/315 (2%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 ++ L F + LG GSFG+VML + K T +A+KIL K V++ +E T+ EKR+ Sbjct: 14 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 73 Query: 96 LQA-VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 L PFL +L F+ LY VMEYV GG++ H++++GRF EPHA FYAA+I + Sbjct: 74 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 133 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEII 211 +L S +IYRDLK +N+++D +G+I++ DFG K T T CGTP+Y+APEII Sbjct: 134 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 193 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 + Y K+VDWWA GVL+YEM AG PF + ++++ I+ V +P S + + + Sbjct: 194 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICK 253 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331 L+ KR G G DIK H +F DW + +++++ P+ PK G NFD + Sbjct: 254 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRN-AENFDRF 312 Query: 332 --EEEEIRVSINEKC 344 + +++ Sbjct: 313 FTRHPPVLTPPDQEV 327 >1VZO-A nrPDB Length = 355 Score = 318 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 121/307 (39%), Positives = 185/307 (60%), Gaps = 15/307 (4%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHK---ETGNHFAMKILDKQKVV-KLKQIEHTLNE 92 ++ FE +K LGTG++G+V LV+ +TG +AMK+L K +V K K EHT E Sbjct: 49 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 108 Query: 93 KRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151 +++L+ + PFLV L Y+F+ + L+++++Y+ GGE+F+HL + RF+E + Y +I Sbjct: 109 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 168 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV----KGRTWTLCGTPEYLA 207 VL E+LH L +IYRD+K EN+L+D G++ +TDFG +K R + CGT EY+A Sbjct: 169 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMA 228 Query: 208 PEIILSK--GYNKAVDWWALGVLIYEMAAGYPPFFAD----QPIQIYEKIVSGKVRFPSH 261 P+I+ G++KAVDWW+LGVL+YE+ G PF D +I +I+ + +P Sbjct: 229 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 288 Query: 262 FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG 321 S+ KDL++ LL D KR G ++IK H +F +W + +KV APF P + Sbjct: 289 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 348 Query: 322 PGDTSNF 328 D SNF Sbjct: 349 ELDVSNF 355 >5ES1-A nrPDB Length = 328 Score = 316 bits (811), Expect = 8e-87, Method: Composition-based stats. Identities = 103/323 (31%), Positives = 167/323 (51%), Gaps = 22/323 (6%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 + H+ + ++T+G G+F +V L +H TG A+KI+DK ++ ++ E RI Sbjct: 9 EEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN-PSSLQKLFREVRI 67 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 ++ +N P +VKL + LY+VMEY GE+F +L GR E AR QIV Sbjct: 68 MKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAV 127 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILS 213 Y H ++++RDLK ENLL+D + I++ DFGF+ + T CG+P Y APE+ Sbjct: 128 HYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQG 187 Query: 214 KGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 K Y+ VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D + +LR Sbjct: 188 KKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRR 247 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD--- 329 L ++ KR + I KW Y+ + P+ + GDT + Sbjct: 248 FLVLNPAKRC-----TLEQIMKDKWI-----NIGYEGEELKPYTEPEEDFGDTKRIEVMV 297 Query: 330 --DYEEEEIRVSINEKCGKEFSE 350 Y EEI+ S+ ++++E Sbjct: 298 GMGYTREEIKESL---TSQKYNE 317 >6E9W-A nrPDB Length = 443 Score = 315 bits (808), Expect = 1e-86, Method: Composition-based stats. Identities = 121/339 (35%), Positives = 192/339 (56%), Gaps = 20/339 (5%) Query: 13 QESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAM 72 +++ FL++ K+ K + +E +K +G G+FG V LV+HK T +AM Sbjct: 77 NKNIDNFLSRYKDTINK----IRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAM 132 Query: 73 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSH 132 K+L K +++K E+ I+ N P++V+L Y+F+D+ LYMVMEY+PGG++ + Sbjct: 133 KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL 192 Query: 133 LRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV 192 + E ARFY A++VL + +HS+ I+RD+KP+N+L+D+ G++++ DFG ++ Sbjct: 193 MSNYD-VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKM 251 Query: 193 KG----RTWTLCGTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQP 244 R T GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD Sbjct: 252 NKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSL 311 Query: 245 IQIYEKIVSGK--VRFPS--HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 + Y KI++ K + FP S + K+L+ L D R G +NGV +IK H +F Sbjct: 312 VGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLT-DREVRLG--RNGVEEIKRHLFFKN 368 Query: 301 TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVS 339 W R AP +P DTSNFDD EE++ Sbjct: 369 DQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEE 407 >4REW-A nrPDB Length = 540 Score = 315 bits (807), Expect = 2e-86, Method: Composition-based stats. Identities = 101/316 (31%), Positives = 163/316 (51%), Gaps = 24/316 (7%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 + + + TLG G+FG+V + KH+ TG+ A+KIL++QK+ L + E + L Sbjct: 1 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNL 60 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + P ++KL S+++MVMEYV GGE+F ++ + GR E +R QI+ + Sbjct: 61 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSK 214 Y H +++RDLKPEN+L+D ++ DFG + + + T CG+P Y APE+I + Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 180 Query: 215 GY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 Y VD W+ GV++Y + G PF D +++KI G P + + + LL+++ Sbjct: 181 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 240 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333 LQVD KR + DI+ H+WF +PK+ P D S + Sbjct: 241 LQVDPMKR-----ASIKDIREHEWFKQD--------------LPKYLFPEDPSYSSTMID 281 Query: 334 EEIRVSINEK--CGKE 347 +E + EK C +E Sbjct: 282 DEALKEVCEKFECSEE 297 >5KZ7-A nrPDB Length = 346 Score = 314 bits (806), Expect = 3e-86, Method: Composition-based stats. Identities = 107/321 (33%), Positives = 168/321 (52%), Gaps = 16/321 (4%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 A H+ + +KT+G G+F +V L +H TG A+KI+DK ++ ++ E R Sbjct: 26 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS-LQKLFREVR 84 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 I++ +N P +VKL + LY+VMEY GGE+F +L GR E AR QIV Sbjct: 85 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 144 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIIL 212 +Y H +++RDLK ENLL+D I++ DFGF+ + T CG+P Y APE+ Sbjct: 145 VQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQ 204 Query: 213 SKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 K Y+ VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D ++LL+ Sbjct: 205 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 264 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD- 330 L ++ +KR + I +W + VE +P +K P T Sbjct: 265 KFLILNPSKR-----GTLEQIMKDRWMNVGHEDDELKPYVEP--LPDYKDPRRTELMVSM 317 Query: 331 -YEEEEIRVSINEKCGKEFSE 350 Y EEI+ S+ G+ ++E Sbjct: 318 GYTREEIQDSL---VGQRYNE 335 >2QNJ-A nrPDB Length = 328 Score = 313 bits (803), Expect = 6e-86, Method: Composition-based stats. Identities = 103/316 (32%), Positives = 165/316 (52%), Gaps = 19/316 (6%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + H+ + +KT+G G+F +V L +H TG A+KI+DK ++ ++ E R Sbjct: 5 SDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTS-LQKLFREVR 63 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 I++ +N P +VKL + LY++MEY GGE+F +L GR E AR QIV Sbjct: 64 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSA 123 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIIL 212 +Y H +++RDLK ENLL+D I++ DFGF+ G+ T CG+P Y APE+ Sbjct: 124 VQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQ 183 Query: 213 SKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 K Y+ VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D ++LL+ Sbjct: 184 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 243 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD-- 329 L ++ KR + I +W A ++ PF+ D D Sbjct: 244 RFLVLNPIKR-----GTLEQIMKDRWI-----NAGHEEDELKPFVEPELDISDQKRIDIM 293 Query: 330 ---DYEEEEIRVSINE 342 Y +EEI+ S+++ Sbjct: 294 VGMGYSQEEIQESLSK 309 >4OTD-A nrPDB Length = 341 Score = 313 bits (802), Expect = 8e-86, Method: Composition-based stats. Identities = 120/302 (39%), Positives = 181/302 (59%), Gaps = 7/302 (2%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 ++ L+ F+ + LG G FG+V+L + + +G FA+K L K +V ++E + EKR Sbjct: 5 RKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKR 64 Query: 95 ILQAV---NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151 IL AV PFLV L F+ ++ VMEY GG++ H+ FSEP A FY+A + Sbjct: 65 ILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACV 123 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAP 208 VL ++LH ++YRDLK +NLL+D +GY+++ DFG K RT T CGTPE+LAP Sbjct: 124 VLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268 E++ Y +AVDWW LGVL+YEM G PF D ++++ IV+ +VR+P S++ Sbjct: 184 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 243 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 328 ++R LL+ + +R G+ + D+K +F T W A+ R++ PF+P G D SNF Sbjct: 244 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 303 Query: 329 DD 330 D+ Sbjct: 304 DE 305 >6ED6-A nrPDB Length = 415 Score = 309 bits (793), Expect = 9e-85, Method: Composition-based stats. Identities = 116/330 (35%), Positives = 192/330 (58%), Gaps = 20/330 (6%) Query: 22 KAKEDFLKKWENPAQNTAHL----DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK 77 K ++FL ++E + L + ++ +K +G G+FG V LV+HK + +AMK+L K Sbjct: 64 KNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSK 123 Query: 78 QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG 137 +++K E+ I+ N P++V+L Y+F+D+ LYMVMEY+PGG++ + + Sbjct: 124 FEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD 183 Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW 197 E A+FY A++VL + +HS+ LI+RD+KP+N+L+D+ G++++ DFG ++ Sbjct: 184 -VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGM 242 Query: 198 ----TLCGTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE 249 T GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD + Y Sbjct: 243 VHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYS 302 Query: 250 KIVSGK--VRFPS--HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIA 305 KI+ K + FP S K+L+ L D R G +NGV +I+ H +F W Sbjct: 303 KIMDHKNSLCFPEDAEISKHAKNLICAFLT-DREVRLG--RNGVEEIRQHPFFKNDQWHW 359 Query: 306 IYQRKVEAPFIPKFKGPGDTSNFDDYEEEE 335 R+ AP +P+ D+SNFDD E+++ Sbjct: 360 DNIRETAAPVVPELSSDIDSSNFDDIEDDK 389 >4CFH-A nrPDB Length = 493 Score = 309 bits (791), Expect = 1e-84, Method: Composition-based stats. Identities = 101/317 (31%), Positives = 162/317 (51%), Gaps = 24/317 (7%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 + + TLG G+FG+V + KH+ TG+ A+KIL++QK+ L + E + Sbjct: 27 DGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQN 86 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ P ++KL S+++MVMEYV GGE+F ++ + GR E +R QI+ Sbjct: 87 LKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 146 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILS 213 +Y H +++RDLKPEN+L+D ++ DFG + + + T CG+P Y APE+I Sbjct: 147 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 214 KGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 + Y VD W+ GV++Y + G PF D +++KI G P + + + LL++ Sbjct: 207 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 266 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 332 +LQVD KR + DI+ H+WF +PK+ P D S Sbjct: 267 MLQVDPMKR-----ATIKDIREHEWFKQD--------------LPKYLFPEDPSYSSTMI 307 Query: 333 EEEIRVSINEK--CGKE 347 ++E + EK C +E Sbjct: 308 DDEALKEVCEKFECSEE 324 >4RED-A nrPDB Length = 351 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 101/316 (31%), Positives = 163/316 (51%), Gaps = 24/316 (7%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 + + + TLG G+FG+V + KH+ TG+ A+KIL++QK+ L + E + L Sbjct: 9 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNL 68 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + P ++KL S+++MVMEYV GGE+F ++ + GR E +R QI+ + Sbjct: 69 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 128 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSK 214 Y H +++RDLKPEN+L+D ++ DFG + + + T CG+P Y APE+I + Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 Query: 215 GY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 Y VD W+ GV++Y + G PF D +++KI G P + + + LL+++ Sbjct: 189 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 248 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333 LQVD KR + DI+ H+WF +PK+ P D S + Sbjct: 249 LQVDPMKR-----ASIKDIREHEWFKQD--------------LPKYLFPEDPSYSTTMID 289 Query: 334 EEIRVSINEK--CGKE 347 +E + EK C +E Sbjct: 290 DEALKEVCEKFECSEE 305 >3TKU-A nrPDB Length = 433 Score = 306 bits (783), Expect = 1e-83, Method: Composition-based stats. Identities = 114/334 (34%), Positives = 186/334 (55%), Gaps = 25/334 (7%) Query: 20 LAKAKEDFLKKWENP-----AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKI 74 +W P + H + FE IK +G G+FG V +VK K T +AMKI Sbjct: 63 RRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKI 122 Query: 75 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR 134 L+K +++K + E+ +L + ++ L Y+F+D ++LY+VM+Y GG++ + L Sbjct: 123 LNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLS 182 Query: 135 RI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK 193 + + E ARFY ++VL + +H L ++RD+KP+N+L+D G+I++ DFG ++ Sbjct: 183 KFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMN 242 Query: 194 GR----TWTLCGTPEYLAPEIILS-----KGYNKAVDWWALGVLIYEMAAGYPPFFADQP 244 + GTP+Y++PEI+ + Y DWW+LGV +YEM G PF+A+ Sbjct: 243 DDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESL 302 Query: 245 IQIYEKIVSG--KVRFPSH---FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 ++ Y KI++ + +FPSH S + KDL++ L+ +R G +NG+ D K H +F Sbjct: 303 VETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICS-RERRLG--QNGIEDFKKHAFFE 359 Query: 300 TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333 +W I R +EAP+IP P DTSNFD ++ Sbjct: 360 GLNWENI--RNLEAPYIPDVSSPSDTSNFDVDDD 391 >4AW2-A nrPDB Length = 437 Score = 304 bits (780), Expect = 3e-83, Method: Composition-based stats. Identities = 117/324 (36%), Positives = 185/324 (57%), Gaps = 25/324 (7%) Query: 30 KWENP-----AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLK 84 +W P Q H + FE +K +G G+FG V +VK K FAMKIL+K +++K Sbjct: 57 EWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRA 116 Query: 85 QIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPH 143 + E+ +L + ++ L Y+F+D++NLY+VM+Y GG++ + L + R E Sbjct: 117 ETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEM 176 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR----TWTL 199 ARFY A++V+ + +H L ++RD+KP+N+L+D G+I++ DFG ++ + Sbjct: 177 ARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVA 236 Query: 200 CGTPEYLAPEIIL-----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254 GTP+Y++PEI+ Y DWW+LGV +YEM G PF+A+ ++ Y KI++ Sbjct: 237 VGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 296 Query: 255 K--VRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQR 309 K +FP + S + KDL+R L+ R G +NG+ D K H +F+ DW I R Sbjct: 297 KERFQFPTQVTDVSENAKDLIRRLICS-REHRLG--QNGIEDFKKHPFFSGIDWDNI--R 351 Query: 310 KVEAPFIPKFKGPGDTSNFDDYEE 333 EAP+IP+ P DTSNFD ++ Sbjct: 352 NCEAPYIPEVSSPTDTSNFDVDDD 375 >4CFF-A nrPDB Length = 571 Score = 304 bits (778), Expect = 5e-83, Method: Composition-based stats. Identities = 96/311 (30%), Positives = 157/311 (50%), Gaps = 22/311 (7%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 + + TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + E + Sbjct: 27 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 86 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ P ++KL ++ +MVMEYV GGE+F ++ + GR E AR QI+ Sbjct: 87 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 146 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILS 213 +Y H +++RDLKPEN+L+D ++ DFG + + + T CG+P Y APE+I Sbjct: 147 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 214 KGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 + Y VD W+ GV++Y + G PF + +++KI G P + + + LL + Sbjct: 207 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 266 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 332 +LQVD KR + DI+ H+WF +P + P D S + Sbjct: 267 MLQVDPLKR-----ATIKDIREHEWFKQD--------------LPSYLFPEDPSYDANVI 307 Query: 333 EEEIRVSINEK 343 ++E + EK Sbjct: 308 DDEAVKEVCEK 318 >4CRS-A nrPDB Length = 341 Score = 303 bits (777), Expect = 6e-83, Method: Composition-based stats. Identities = 127/311 (40%), Positives = 181/311 (58%), Gaps = 9/311 (2%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 +L F L G FG+V+L ++K T FA+K L K +V +++ + EKRI + V Sbjct: 10 NLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 69 Query: 100 N---FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 N PFLV L F+ ++ VMEY GG++ H+ FSEP A FYAA +VL + Sbjct: 70 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVVLGLQ 128 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILS 213 YLH ++YRDLK +NLL+D +G++++ DFG K RT T CGTPE+LAPE++ Sbjct: 129 YLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE 188 Query: 214 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 Y +AVDWW LGVLIYEM G PF D ++++ IV+ +VR+P S++ ++R L Sbjct: 189 TSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRL 248 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD--Y 331 L+ + +R G + D+K H +F DW A+ +KV+ PFIP +G D SNFDD Sbjct: 249 LRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFT 308 Query: 332 EEEEIRVSINE 342 E I E Sbjct: 309 SEAPILTPPRE 319 >3HZT-A nrPDB Length = 467 Score = 303 bits (776), Expect = 9e-83, Method: Composition-based stats. Identities = 88/266 (33%), Positives = 144/266 (54%), Gaps = 15/266 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++R+K LG+G++G V+L K K TG A+KI+ K V L+E +L+ ++ Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL F+D N Y+VME GGE+F + +FSE A Q++ YLH Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 123 Query: 162 DLIYRDLKPENLLID---QQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGY 216 ++++RDLKPENLL++ + I++ DFG + + G+ GT Y+APE++ K Y Sbjct: 124 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR-KKY 182 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRN 272 ++ D W+ GV++Y + GYPPF +I +++ GK F S + K L++ Sbjct: 183 DEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKL 242 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWF 298 +L + +KR + NH W Sbjct: 243 MLTYEPSKRI-----SAEEALNHPWI 263 >5EZV-A nrPDB Length = 560 Score = 302 bits (774), Expect = 1e-82, Method: Composition-based stats. Identities = 99/320 (30%), Positives = 163/320 (50%), Gaps = 27/320 (8%) Query: 32 ENPAQNTAH-----LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI 86 ++PA+ H + + TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + Sbjct: 13 QDPAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV 72 Query: 87 EHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 146 E + L+ P ++KL ++ +MVMEYV GGE+F ++ + GR E AR Sbjct: 73 GKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARR 132 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPE 204 QI+ +Y H +++RDLKPEN+L+D ++ DFG + + + T CG+P Sbjct: 133 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 192 Query: 205 YLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS 263 Y APE+I + Y VD W+ GV++Y + G PF + +++KI G P + + Sbjct: 193 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 252 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPG 323 + LL ++LQVD KR + DI+ H+WF +P + P Sbjct: 253 RSVATLLMHMLQVDPLKR-----ATIKDIREHEWFKQD--------------LPSYLFPE 293 Query: 324 DTSNFDDYEEEEIRVSINEK 343 D S + ++E + EK Sbjct: 294 DPSYDANVIDDEAVKEVCEK 313 >3DXN-A nrPDB Length = 287 Score = 302 bits (774), Expect = 1e-82, Method: Composition-based stats. Identities = 88/266 (33%), Positives = 144/266 (54%), Gaps = 15/266 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++R+K LG+G++G V+L K K TG A+KI+ K V L+E +L+ ++ Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL F+D N Y+VME GGE+F + +FSE A Q++ YLH Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 140 Query: 162 DLIYRDLKPENLLID---QQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGY 216 ++++RDLKPENLL++ + I++ DFG + + G+ GT Y+APE++ K Y Sbjct: 141 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR-KKY 199 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRN 272 ++ D W+ GV++Y + GYPPF +I +++ GK F S + K L++ Sbjct: 200 DEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKL 259 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWF 298 +L + +KR + NH W Sbjct: 260 MLTYEPSKRI-----SAEEALNHPWI 280 >5JN2-A nrPDB Length = 525 Score = 301 bits (770), Expect = 4e-82, Method: Composition-based stats. Identities = 88/280 (31%), Positives = 141/280 (50%), Gaps = 15/280 (5%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 D+++ + LG GSFG V+L K K TG A+K++ K++V + E L E ++ Sbjct: 61 STAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQL 120 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ ++ P ++KL F+D Y+V E GGE+F + RFSE A Q++ Sbjct: 121 LKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGI 180 Query: 156 EYLHSLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI 210 Y+H +++RDLKPENLL++ + I++ DFG + + + GT Y+APE+ Sbjct: 181 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 240 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF--PSH--FSSDL 266 + Y++ D W+ GV++Y + +G PPF I +K+ GK F P S Sbjct: 241 LHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESA 299 Query: 267 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAI 306 KDL+R +L + R D +H+W T I Sbjct: 300 KDLIRKMLTYVPSMRI-----SARDALDHEWIQTYTKEQI 334 >4D28-A nrPDB Length = 446 Score = 300 bits (768), Expect = 7e-82, Method: Composition-based stats. Identities = 91/293 (31%), Positives = 158/293 (53%), Gaps = 10/293 (3%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 + + ++E +T+G G+F +V ++ +TG++ A+KI+ K ++K + ++ E I Sbjct: 3 KKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 ++ V P +V+L S +Y+V+E+V GGE+F + GR E +R Y Q+V Sbjct: 63 MKIVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAV 122 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIIL 212 + HS + +RDLKPENLL+D G ++V+DFG + + L CGTP Y+APE++ Sbjct: 123 AHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLS 182 Query: 213 SKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 +GY+ A D W+ GV+++ + AGY PF +Y KI + + P FS+++K L+ Sbjct: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIH 242 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGD 324 +L + R + IK WF +++ I R+ E + + D Sbjct: 243 RILDPNPKTRI-----QIQGIKKDPWFRK-NYVPIRAREEEEVNLDDIRAVFD 289 >4TNB-A nrPDB Length = 590 Score = 299 bits (767), Expect = 9e-82, Method: Composition-based stats. Identities = 98/326 (30%), Positives = 169/326 (51%), Gaps = 8/326 (2%) Query: 4 AAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH 63 A + + E E+L D +W+ + + F + + LG G FG V + Sbjct: 146 AQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQV 205 Query: 64 KETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEY 123 + TG +A K L+K+++ K K LNEK+IL+ VN F+V L Y+++ L +V+ Sbjct: 206 RATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTI 265 Query: 124 VPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI 181 + GG++ H+ +G F E A FYAA+I+ E LH + +YRDLKPEN+L+D G+I Sbjct: 266 MNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVYRDLKPENILLDDYGHI 325 Query: 182 QVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 +++D G A ++ GT Y+APE++ ++ Y + D+W LG LIYEM G PF Sbjct: 326 RISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 Query: 240 FADQPI----QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNH 295 + ++ +++ + + FS + K + + LL D +R G + ++K H Sbjct: 386 RGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRH 445 Query: 296 KWFATTDWIAIYQRKVEAPFIPKFKG 321 +F ++ + ++ PF+P + Sbjct: 446 PFFRNMNFKRLEAGMLDPPFVPDPRA 471 >5LOH-A nrPDB Length = 341 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 113/341 (33%), Positives = 183/341 (53%), Gaps = 26/341 (7%) Query: 2 GNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV 61 G GS++E A E+ + + P + +++F +K + G+FG+V L Sbjct: 1 GPHMDPTAGSKKEPGG---GAATEEGVNRIAVPKPPS--IEEFSIVKPISRGAFGKVYLG 55 Query: 62 KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVM 121 + + G +A+K++ K ++ E+ L PF+V L YS + +N+Y+VM Sbjct: 56 Q--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVM 113 Query: 122 EYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI 181 EY+ GG++ S L G F E A Y +++ L +YLH +I+RDLKP+N+LI +G+I Sbjct: 114 EYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHI 173 Query: 182 QVTDFGFAKRVKGR---------TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232 ++TDFG +K R T T CGTP+YLAPE++L + + AVDWWALGV ++E Sbjct: 174 KLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEF 233 Query: 233 AAGYPPFFADQPIQIYEKIVSGKVRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGV 289 G PPF + P Q+++ I+ + +P S + + + LL +D TKR G+ Sbjct: 234 LTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKR-----AGM 288 Query: 290 NDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 ++K H F+ DW + + + PFIP+ DTS F+ Sbjct: 289 KELKRHPLFSDVDWENLQHQTM--PFIPQPDDETDTSYFEA 327 >4CZT-A nrPDB Length = 464 Score = 297 bits (762), Expect = 3e-81, Method: Composition-based stats. Identities = 89/270 (32%), Positives = 148/270 (54%), Gaps = 11/270 (4%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 + ++E +TLG G+F +V ++ E G++ A+K++DK+KV+K K I E Sbjct: 5 SGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 64 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 ++ + P ++++ + +Y V+E+V GGE+F + GR E AR Y Q++ Sbjct: 65 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 124 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----RVKGRTWTLCGTPEYLAPEI 210 +Y HS + +RDLKPENLL+D G ++V+DFG + R G T CGTP Y+APE+ Sbjct: 125 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 184 Query: 211 ILSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDL 269 I +KGY+ D W+ GV+++ + AGY PF +Y+KI + P FS+ K L Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL 244 Query: 270 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 ++ +L + R ++ ++WF Sbjct: 245 IKRILDPNPATRI-----TFAEVIENEWFK 269 >5FG8-A nrPDB Length = 285 Score = 297 bits (760), Expect = 6e-81, Method: Composition-based stats. Identities = 86/277 (31%), Positives = 144/277 (51%), Gaps = 16/277 (5%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK 93 PA T D ++ + LG G+F V K TG FA KI++ +K+ + + E Sbjct: 6 PAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTA-RDFQKLEREA 64 Query: 94 RILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 RI + ++ P +V+L S ++ + Y+V + V GGE+F + +SE A QI+ Sbjct: 65 RICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILE 124 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGY---IQVTDFGFAKRVKGRT---WTLCGTPEYLA 207 + + H +++RDLKPENLL+ + +++ DFG A V+G + GTP YL+ Sbjct: 125 SVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLS 184 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FS 263 PE++ + Y K+VD WA GV++Y + GYPPF+ + ++Y +I +G +PS + Sbjct: 185 PEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVT 244 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 + K+L+ +L V+ KR + H W Sbjct: 245 PEAKNLINQMLTVNPNKRI-----TAAEALKHPWICQ 276 >2VN9-A nrPDB Length = 301 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 84/282 (29%), Positives = 142/282 (50%), Gaps = 16/282 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ + LG G+F V TG +A KI++ +K+ + + E RI + + Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSA-RDHQKLEREARICRLLKH 62 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+L S + Y+V + V GGE+F + +SE A QI+ + + H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 162 DLIYRDLKPENLLIDQQGY---IQVTDFGFAKRVKGRT---WTLCGTPEYLAPEIILSKG 215 +++RDLKPENLL+ + +++ DFG A V+G + GTP YL+PE++ Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLR 271 Y K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + KDL+ Sbjct: 183 YGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 242 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 +L ++ KR ++ H W +A + E Sbjct: 243 KMLTINPAKRI-----TASEALKHPWICQRSTVASMMHRQET 279 >3C51-A nrPDB Length = 543 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 108/317 (34%), Positives = 168/317 (52%), Gaps = 11/317 (3%) Query: 13 QESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAM 72 Q +EFL +W+ D F + LG G FG V + K TG +A Sbjct: 156 QAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYAC 215 Query: 73 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSH 132 K L+K+++ K K + + EK+IL V+ F+V L Y+F+ ++L +VM + GG++ H Sbjct: 216 KKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYH 275 Query: 133 LRRIGR----FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF 188 + + F EP A FY AQIV E+LH ++IYRDLKPEN+L+D G ++++D G Sbjct: 276 IYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGL 335 Query: 189 AKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD--- 242 A +K +T GTP ++APE++L + Y+ +VD++ALGV +YEM A PF A Sbjct: 336 AVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEK 395 Query: 243 -QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 + ++ ++++ V +P FS KD LLQ D KR G + ++ H F Sbjct: 396 VENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDI 455 Query: 302 DWIAIYQRKVEAPFIPK 318 W + + PF+P Sbjct: 456 SWRQLEAGMLTPPFVPD 472 >3ORZ-A nrPDB Length = 316 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 104/279 (37%), Positives = 165/279 (59%), Gaps = 8/279 (2%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + F+ K LG GSF V+L + T +A+KIL+K+ ++K ++ + E+ ++ ++ Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 PF VKL + F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216 +I+RDLKPEN+L+++ +IQ+TDFG AK + + R + GT +Y++PE++ K Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 216 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL + Sbjct: 217 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 276 Query: 277 DLTKRFGNLK-NGVNDIKNHKWFATTDWIAIYQRKVEAP 314 D TKR G + G +K H +F + W ++Q+ P Sbjct: 277 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 313 >4MVF-A nrPDB Length = 506 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 85/268 (31%), Positives = 144/268 (53%), Gaps = 18/268 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D++ + LG G++G V K T +A+K K +LK I E I++ ++ Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKD---RLKNINRFFQEIEIMKKLDH 113 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +VKL ++++++ +Y++ME G E+F + G F+E +A QI YLHSL Sbjct: 114 PNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSL 173 Query: 162 DLIYRDLKPENLLI---DQQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSKGY 216 ++++RDLKPEN L ++ +++ DFG +K + T T GTP Y+AP+++ K Y Sbjct: 174 NIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGK-Y 232 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRN 272 +K D W+ GV++Y + GYPPF+ D ++ +K+ G+ F + SSD K+L+ Sbjct: 233 DKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITK 292 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 LL + +R + + NH W Sbjct: 293 LLTYNPNERC-----TIEEALNHPWITQ 315 >5IG1-A nrPDB Length = 344 Score = 294 bits (754), Expect = 3e-80, Method: Composition-based stats. Identities = 86/283 (30%), Positives = 147/283 (51%), Gaps = 15/283 (5%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 +G G+F V +K TG A+K++ + + + +I E I ++ +V + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSL-RSSEINKIKREIGICSSLQHEHIVSMR 82 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 +F+D S+ Y+V EYV GGE+F + ++E A QI+ ++ HS ++I+RDL Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDL 142 Query: 169 KPENLLI---DQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGYNKAVDWW 223 KPENLL+ D +++TDFG A ++ + GTP YL+PE+I Y+ AVD W Sbjct: 143 KPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPYDTAVDVW 202 Query: 224 ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRNLLQVDLT 279 A GV++Y + GYPPF+ + ++Y +I + + FPS ++ K+L++ +L+ + Sbjct: 203 ACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEPNPK 262 Query: 280 KRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP 322 +R V ++ H W A D R+ + KF Sbjct: 263 RR-----PTVQELLQHPWIARRDVPGSVHRQATLEELKKFNAR 300 >3MA6-A nrPDB Length = 298 Score = 294 bits (754), Expect = 3e-80, Method: Composition-based stats. Identities = 87/279 (31%), Positives = 140/279 (50%), Gaps = 15/279 (5%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 D+++ + LG GSFG V+L K K TG A+K++ K++V + E L E ++ Sbjct: 26 STAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQL 85 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ ++ P ++KL F+D Y+V E GGE+F + RFSE A Q++ Sbjct: 86 LKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGI 145 Query: 156 EYLHSLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI 210 Y+H +++RDLKPENLL++ + I++ DFG + + + GT Y+APE+ Sbjct: 146 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 205 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF--PSH--FSSDL 266 + Y++ D W+ GV++Y + +G PPF I +K+ GK F P S Sbjct: 206 LHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESA 264 Query: 267 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIA 305 KDL+R +L + R D +H+W T Sbjct: 265 KDLIRKMLTYVPSMRI-----SARDALDHEWIQTYTKEQ 298 >5UUU-A nrPDB Length = 547 Score = 294 bits (752), Expect = 6e-80, Method: Composition-based stats. Identities = 103/333 (30%), Positives = 180/333 (54%), Gaps = 11/333 (3%) Query: 16 VKEFLAKAKEDFLKKWENPAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKI 74 ++F+ K +W+N N ++ F + +G G FG V + +TG +AMK Sbjct: 171 FQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKC 230 Query: 75 LDKQKVVKLKQIEHTLNEKRILQAV---NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 LDK+++ + LNE+ +L V + PF+V + Y+F L +++ + GG++ Sbjct: 231 LDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHY 290 Query: 132 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191 HL + G FSE RFYAA+I+L E++H+ ++YRDLKP N+L+D+ G+++++D G A Sbjct: 291 HLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD 350 Query: 192 V-KGRTWTLCGTPEYLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE 249 K + GT Y+APE++ Y+ + DW++LG +++++ G+ PF + +E Sbjct: 351 FSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE 410 Query: 250 ---KIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAI 306 ++ V P FS +L+ LL LLQ D+ +R G L G ++K +F + DW + Sbjct: 411 IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMV 470 Query: 307 YQRKVEAPFIPKFKGPGDTSNFD--DYEEEEIR 337 + +K P IP FD ++EE+ + Sbjct: 471 FLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 503 >2V7O-A nrPDB Length = 336 Score = 293 bits (750), Expect = 9e-80, Method: Composition-based stats. Identities = 85/293 (29%), Positives = 146/293 (49%), Gaps = 16/293 (5%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 +++ A T D ++ + LG G+F V K +A KI++ +K+ + + Sbjct: 20 FQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSA-RDHQKLE 78 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 E RI + + P +V+L S + Y+V + V GGE+F + +SE A Q Sbjct: 79 REARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQ 138 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGY---IQVTDFGFAKRVKGRT---WTLCGTPE 204 I+ + ++H D+++RDLKPENLL+ + +++ DFG A V+G + GTP Sbjct: 139 ILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPG 198 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH--- 261 YL+PE++ Y K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS Sbjct: 199 YLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWD 258 Query: 262 -FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 + + K+L+ +L ++ KR + H W +A + E Sbjct: 259 TVTPEAKNLINQMLTINPAKRI-----TADQALKHPWVCQRSTVASMMHRQET 306 >3PVW-A nrPDB Length = 695 Score = 292 bits (749), Expect = 1e-79, Method: Composition-based stats. Identities = 103/333 (30%), Positives = 180/333 (54%), Gaps = 11/333 (3%) Query: 16 VKEFLAKAKEDFLKKWENPAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKI 74 ++F+ K +W+N N ++ F + +G G FG V + +TG +AMK Sbjct: 162 FQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKC 221 Query: 75 LDKQKVVKLKQIEHTLNEKRILQAV---NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 LDK+++ + LNE+ +L V + PF+V + Y+F L +++ + GG++ Sbjct: 222 LDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHY 281 Query: 132 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191 HL + G FSE RFYAA+I+L E++H+ ++YRDLKP N+L+D+ G+++++D G A Sbjct: 282 HLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD 341 Query: 192 V-KGRTWTLCGTPEYLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE 249 K + GT Y+APE++ Y+ + DW++LG +++++ G+ PF + +E Sbjct: 342 FSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE 401 Query: 250 ---KIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAI 306 ++ V P FS +L+ LL LLQ D+ +R G L G ++K +F + DW + Sbjct: 402 IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMV 461 Query: 307 YQRKVEAPFIPKFKGPGDTSNFD--DYEEEEIR 337 + +K P IP FD ++EE+ + Sbjct: 462 FLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 >3NYO-A nrPDB Length = 576 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 99/327 (30%), Positives = 162/327 (49%), Gaps = 10/327 (3%) Query: 15 SVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKI 74 ++L + +W+ + + F + + LG G FG V + + TG +A K Sbjct: 157 PFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKK 216 Query: 75 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR 134 L+K+++ K K LNEK+IL+ VN F+V L Y+++ L +V+ + GG++ H+ Sbjct: 217 LEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY 276 Query: 135 RIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV 192 +G+ F E A FYAA+I E LH ++YRDLKPEN+L+D G+I+++D G A V Sbjct: 277 HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV 336 Query: 193 KG--RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI----Q 246 GT Y+APE++ ++ Y + DWWALG L+YEM AG PF + + Sbjct: 337 PEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE 396 Query: 247 IYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAI 306 + + + FS + L LL D +R G ++K H F ++ + Sbjct: 397 VERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRL 456 Query: 307 YQRKVEAPFIPKFKGP--GDTSNFDDY 331 +E PF P + D + + + Sbjct: 457 GAGMLEPPFKPDPQAIYCKDVLDIEQF 483 >2BDW-A nrPDB Length = 362 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 91/320 (28%), Positives = 152/320 (47%), Gaps = 28/320 (8%) Query: 3 NAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVK 62 + A+ G + EF+ A F D ++ + LG G+F V Sbjct: 3 HMASMTGGQQMGRGSEFMMNASTKFS-------------DNYDVKEELGKGAFSVVRRCV 49 Query: 63 HKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVME 122 HK TG FA KI++ +K+ + + E RI + + P +V+L S ++ S Y+V + Sbjct: 50 HKTTGLEFAAKIINTKKLSA-RDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFD 108 Query: 123 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-- 180 V GGE+F + +SE A QI+ + Y HS +++R+LKPENLL+ + Sbjct: 109 LVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGA 168 Query: 181 -IQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYP 237 +++ DFG A V GTP YL+PE++ Y+K VD WA GV++Y + GYP Sbjct: 169 AVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYP 228 Query: 238 PFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIK 293 PF+ + ++Y +I +G +PS + + K L+ ++L V+ KR + Sbjct: 229 PFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRI-----TADQAL 283 Query: 294 NHKWFATTDWIAIYQRKVEA 313 W + +A + + Sbjct: 284 KVPWICNRERVASAIHRQDT 303 >2VD5-A nrPDB Length = 412 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 120/348 (34%), Positives = 185/348 (53%), Gaps = 30/348 (8%) Query: 10 GSEQESVKEFLAKAK--EDFLKKWENP-----AQNTAHLDQFERIKTLGTGSFGRVMLVK 62 G QE LA+ K DFL +W P + D FE +K +G G+F V +VK Sbjct: 23 GVHQELGASELAQDKYVADFL-QWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVK 81 Query: 63 HKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVME 122 K+TG +AMKI++K ++K ++ E+ +L + ++ +L ++F+D + LY+VME Sbjct: 82 MKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME 141 Query: 123 YVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI 181 Y GG++ + L + G R ARFY A+IV+ + +H L ++RD+KP+N+L+D+ G+I Sbjct: 142 YYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHI 201 Query: 182 QVTDFGFAKRVKG----RTWTLCGTPEYLAPEIIL-------SKGYNKAVDWWALGVLIY 230 ++ DFG +++ R+ GTP+YL+PEI+ + Y DWWALGV Y Sbjct: 202 RLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAY 261 Query: 231 EMAAGYPPFFADQPIQIYEKIV--SGKVRFP---SHFSSDLKDLLRNLLQVDLTKRFGNL 285 EM G PF+AD + Y KIV + P + +D ++ LL R G Sbjct: 262 EMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLG-- 318 Query: 286 KNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333 + G D + H +F DW + R PF P F+G DT NFD E+ Sbjct: 319 RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGATDTCNFDLVED 364 >3MN3-A nrPDB Length = 271 Score = 291 bits (746), Expect = 2e-79, Method: Composition-based stats. Identities = 86/264 (32%), Positives = 136/264 (51%), Gaps = 9/264 (3%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 AH+ ++ +KTLG GSFG+V L H TG A+KI++K+ + K E L+ Sbjct: 1 AHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRL 60 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + P ++KL K + MV+EY G E+F ++ + + SE AR + QI+ EY Sbjct: 61 LRHPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYC 119 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSKGY 216 H +++RDLKPENLL+D+ +++ DFG + + T CG+P Y APE+I K Y Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 217 -NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 275 VD W+ GV++Y M PF + +++ I +G P S L++ +L Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLI 239 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFA 299 V+ R +++I WF Sbjct: 240 VNPLNRI-----SIHEIMQDDWFK 258 >2JC6-A nrPDB Length = 334 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 98/292 (33%), Positives = 162/292 (55%), Gaps = 20/292 (6%) Query: 20 LAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQK 79 +A+ + W+ A++ + FE +TLGTG+F V+L + K TG FA+K + K+ Sbjct: 2 MARENGESSSSWKKQAEDIKKI--FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKA 59 Query: 80 VVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRF 139 + + NE +L+ + +V LE ++ ++LY+VM+ V GGE+F + G + Sbjct: 60 LKGKE--SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFY 117 Query: 140 SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVKGR- 195 +E A Q++ YLH + +++RDLKPENLL D++ I ++DFG +K ++G+ Sbjct: 118 TEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSK-MEGKG 176 Query: 196 --TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253 T CGTP Y+APE++ K Y+KAVD W++GV+ Y + GYPPF+ + +++E+I+ Sbjct: 177 DVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILK 236 Query: 254 GKVRFPS----HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 + F S S KD +RNL++ D KR+ H W A Sbjct: 237 AEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTC-----EQAARHPWIAGD 283 >4UZD-A nrPDB Length = 287 Score = 290 bits (743), Expect = 5e-79, Method: Composition-based stats. Identities = 83/261 (31%), Positives = 140/261 (53%), Gaps = 6/261 (2%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 L+ FE + LG G FG V L + K++ A+K+L K ++ K E I + Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 P +++L F D + +Y+++EY P G ++ L+++ +F E Y ++ Y HS Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 126 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GRTWTLCGTPEYLAPEIILSKGYNKA 219 +I+RD+KPENLL+ G +++ DFG++ R TLCGT +YL PE+I + +++ Sbjct: 127 KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEK 186 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLT 279 VD W+LGVL YE G PPF A+ + Y++I + FP + +DL+ LL+ + + Sbjct: 187 VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPS 246 Query: 280 KRFGNLKNGVNDIKNHKWFAT 300 +R + ++ H W Sbjct: 247 QR-----PMLREVLEHPWITA 262 >5U6Y-A nrPDB Length = 461 Score = 290 bits (742), Expect = 7e-79, Method: Composition-based stats. Identities = 81/280 (28%), Positives = 141/280 (50%), Gaps = 16/280 (5%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 ++ + LG G+F V G +A KI++ +K+ + + E RI + + P Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSA-RDHQKLEREARICRLLKHPN 60 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 +V+L S + + Y++ + V GGE+F + +SE A QI+ + H + + Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 164 IYRDLKPENLLIDQQGY---IQVTDFGFAKRVKGRT---WTLCGTPEYLAPEIILSKGYN 217 ++RDLKPENLL+ + +++ DFG A V+G + GTP YL+PE++ Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 180 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRNL 273 K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + KDL+ + Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 240 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 L ++ +KR + H W + +A + E Sbjct: 241 LTINPSKRI-----TAAEALKHPWISHRSTVASCMHRQET 275 >3BHH-A nrPDB Length = 295 Score = 289 bits (741), Expect = 9e-79, Method: Composition-based stats. Identities = 81/282 (28%), Positives = 143/282 (50%), Gaps = 16/282 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ + +G G+F V TG+ +A KI++ +K+ + + E RI + + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSA-RDHQKLEREARICRLLKH 62 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 +V+L S + Y+V + V GGE+F + +SE A QI+ + H + Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 162 DLIYRDLKPENLLIDQQGY---IQVTDFGFAKRVKGRT---WTLCGTPEYLAPEIILSKG 215 +++RDLKPENLL+ + +++ DFG A V+G + GTP YL+PE++ + Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLR 271 Y K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + K+L+ Sbjct: 183 YGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLIN 242 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 +L ++ KR ++ H W +A + E Sbjct: 243 QMLTINPAKRI-----TAHEALKHPWVCQRSTVASMMHRQET 279 >2VZ6-A nrPDB Length = 313 Score = 289 bits (740), Expect = 1e-78, Method: Composition-based stats. Identities = 81/280 (28%), Positives = 141/280 (50%), Gaps = 16/280 (5%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 ++ + LG G+F V G +A KI++ +K+ + + E RI + + P Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSA-RDHQKLEREARICRLLKHPN 82 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 +V+L S + + Y++ + V GGE+F + +SE A QI+ + H + + Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 164 IYRDLKPENLLIDQQGY---IQVTDFGFAKRVKGRT---WTLCGTPEYLAPEIILSKGYN 217 ++RDLKPENLL+ + +++ DFG A V+G + GTP YL+PE++ Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 202 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRNL 273 K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + KDL+ + Sbjct: 203 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 262 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 L ++ +KR + H W + +A + E Sbjct: 263 LTINPSKRI-----TAAEALKHPWISHRSTVASCMHRQET 297 >2YZA-A nrPDB Length = 276 Score = 289 bits (740), Expect = 1e-78, Method: Composition-based stats. Identities = 88/269 (32%), Positives = 143/269 (53%), Gaps = 8/269 (2%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 + + TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + E + Sbjct: 5 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 64 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ P ++KL ++ +MVMEYV GGE+F ++ + GR E AR QI+ Sbjct: 65 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 124 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILS 213 +Y H +++RDLKPEN+L+D ++ DFG + + + CG+P Y APE+I Sbjct: 125 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISG 184 Query: 214 KGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 + Y VD W+ GV++Y + G PF + +++KI G P + + + LL + Sbjct: 185 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 244 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 +LQVD KR + DI+ H+WF Sbjct: 245 MLQVDPLKR-----ATIKDIREHEWFKQD 268 >3KK8-A nrPDB Length = 284 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 86/286 (30%), Positives = 144/286 (50%), Gaps = 15/286 (5%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 +T D ++ + LG G+F V HK TG FA KI++ +K+ + + E RI Sbjct: 1 STKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSA-RDFQKLEREARIC 59 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + + P +V+L S ++ S Y+V + V GGE+F + +SE A QI+ + Sbjct: 60 RKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIA 119 Query: 157 YLHSLDLIYRDLKPENLLIDQQGY---IQVTDFGFAKRVKGRT--WTLCGTPEYLAPEII 211 Y HS +++R+LKPENLL+ + +++ DFG A V GTP YL+PE++ Sbjct: 120 YCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL 179 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLK 267 Y+K VD WA GV++Y + GYPPF+ + ++Y +I +G +PS + + K Sbjct: 180 KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAK 239 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 L+ ++L V+ KR + W + +A + + Sbjct: 240 SLIDSMLTVNPKKRI-----TADQALKVPWICNRERVASAIHRQDT 280 >2HAK-A nrPDB Length = 328 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 100/313 (31%), Positives = 159/313 (50%), Gaps = 19/313 (6%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 H+ + KT+G G+F +V L +H TG A+KI+DK ++ ++ E RI Sbjct: 9 DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTS-LQKLFREVRI 67 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 ++ +N P +VKL + LY+VMEY GGE+F +L GR E AR QIV Sbjct: 68 MKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 127 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILS 213 +Y H +++RDLK ENLL+D I++ DFGF+ + T CG+P Y APE+ Sbjct: 128 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQG 187 Query: 214 KGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 K Y+ VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D ++LL+ Sbjct: 188 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 247 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD--- 329 LL ++ KR + I +W ++ + P+ DT D Sbjct: 248 LLVLNPIKR-----GSLEQIMKDRWM-----NVGHEEEELKPYTEPDPDFNDTKRIDIMV 297 Query: 330 --DYEEEEIRVSI 340 + +EI ++ Sbjct: 298 TMGFARDEINDAL 310 >5YKS-A nrPDB Length = 377 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 94/264 (35%), Positives = 145/264 (54%), Gaps = 11/264 (4%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 ++ KTLG G F V L +H TG A+K++DK K+ L H E R ++ V P Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLA-TGHLFQEVRCMKLVQHPN 95 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLHSLD 162 +V+L + LY+++E GG+MF ++ + +E A+ Y AQIV Y H L Sbjct: 96 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 155 Query: 163 LIYRDLKPENL-LIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSKGYN-K 218 +++RDLKPEN+ ++QG +++TDFGF+ + + + T CG+ Y APEI+L Y+ Sbjct: 156 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 215 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278 AVD W+LGV+++ + G PPF + I+ K PSH S + KDL+ +LQ D Sbjct: 216 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDP 275 Query: 279 TKRFGNLKNGVNDIKNHKWFATTD 302 +R + +I+NH W D Sbjct: 276 KRR-----ASLEEIENHPWLQGVD 294 >4YZB-A nrPDB Length = 491 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 90/276 (32%), Positives = 141/276 (51%), Gaps = 15/276 (5%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 A D+++ + LG GSFG V+L K K TG +A+K++ K++V + E L E + Sbjct: 24 STAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVEL 83 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ ++ P ++KL F+D Y+V E GGE+F + RFSE A Q++ Sbjct: 84 LKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGI 143 Query: 156 EYLHSLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI 210 Y+H +++RDLKPENLL++ + I++ DFG + + + GT Y+APE+ Sbjct: 144 TYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEV 203 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDL 266 + Y++ D W+ GV++Y + +G PPF I +K+ GK F S Sbjct: 204 LHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPA 262 Query: 267 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 KDL+R +L T R D H+W TTD Sbjct: 263 KDLIRKMLAYVPTMRI-----SARDALEHEWLKTTD 293 >4RGJ-A nrPDB Length = 520 Score = 287 bits (736), Expect = 4e-78, Method: Composition-based stats. Identities = 89/317 (28%), Positives = 156/317 (49%), Gaps = 26/317 (8%) Query: 3 NAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHL----------DQFERIKTLGT 52 N + K G+E+ +KE + ++ N ++ + +Q++ IK LG Sbjct: 11 NKKSLKGGNERHEMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGK 70 Query: 53 GSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFK 112 GSFG V+L + K TG+ +A+K++ K+ V + E L E +L+ ++ ++KL F+ Sbjct: 71 GSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFFE 130 Query: 113 DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPEN 172 DN+ Y+V + GGE+F + RF E A QI+ Y+H ++++RDLKPEN Sbjct: 131 DNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPEN 190 Query: 173 LLID----QQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG 226 +L++ + I++ DFG + + + GT Y+AP+++ Y++ D W+ G Sbjct: 191 ILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHG-TYDEKCDIWSCG 249 Query: 227 VLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLRNLLQVDLTKRF 282 V++Y + +G PPF I +K+ +GK F S KDL++ +L R Sbjct: 250 VILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRI 309 Query: 283 GNLKNGVNDIKNHKWFA 299 D H+W Sbjct: 310 -----SARDALEHEWIK 321 >3D2K-A nrPDB Length = 272 Score = 287 bits (735), Expect = 4e-78, Method: Composition-based stats. Identities = 82/262 (31%), Positives = 138/262 (52%), Gaps = 6/262 (2%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 L+ F+ + LG G FG V L + +++ A+K+L K ++ K E I + Sbjct: 10 TLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHL 69 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 P +++L F D + +Y+++EY P G ++ L+++ RF E Y ++ Y H Sbjct: 70 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCH 129 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GRTWTLCGTPEYLAPEIILSKGYNK 218 S +I+RD+KPENLL+ G +++ DFG++ R TLCGT +YL PE+I + +++ Sbjct: 130 SKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 189 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278 VD W+LGVL YE G PPF A + Y +I + FP + +DL+ LL+ + Sbjct: 190 KVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNA 249 Query: 279 TKRFGNLKNGVNDIKNHKWFAT 300 ++R + ++ H W Sbjct: 250 SQRL-----TLAEVLEHPWIKA 266 >3NCG-A nrPDB Length = 486 Score = 287 bits (735), Expect = 5e-78, Method: Composition-based stats. Identities = 80/270 (29%), Positives = 137/270 (50%), Gaps = 16/270 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 +++ + LG GSFG V+ K + T +A+K+++K K K L E +L+ ++ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKAS-AKNKDTSTILREVELLKKLDH 80 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL +D+S+ Y+V E GGE+F + + RFSE A Q+ Y+H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 162 DLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSKGY 216 ++++RDLKPEN+L+ ++ I++ DFG + + + GT Y+APE++ Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-TY 199 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF--PSH--FSSDLKDLLRN 272 ++ D W+ GV++Y + +G PPF+ I +++ +GK F P S D KDL+R Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 +L + R H W Sbjct: 260 MLTFHPSLRI-----TATQCLEHPWIQKYS 284 >6BXI-A nrPDB Length = 333 Score = 287 bits (734), Expect = 6e-78, Method: Composition-based stats. Identities = 118/338 (34%), Positives = 185/338 (54%), Gaps = 47/338 (13%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 L+ FE +K +G G+FG V LV+ K+TG+ +AMKIL K +++ +Q+ H E+ IL Sbjct: 1 TRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDIL 60 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + ++VK+ YSF+D NLY++ME++PGG+M + L + +E +FY A+ VL + Sbjct: 61 VEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAID 120 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT------------------ 198 +H L I+RD+KP+NLL+D +G+++++DFG +K T Sbjct: 121 SIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 199 --------------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP 238 GTP+Y+APE+ + GYNK DWW+LGV++YEM GYPP Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 239 FFADQPIQIYEKIVSGK--VRFPSHF--SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKN 294 F ++ P + Y+K+++ K + FP S KDL+ + R G GV +IK+ Sbjct: 241 FCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILR-FCCEWEHRIGA--PGVEEIKS 297 Query: 295 HKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 332 + +F DW I +R A + K DTSNFD++ Sbjct: 298 NSFFEGVDWEHIRER--PAAISIEIKSIDDTSNFDEFP 333 >3LIJ-A nrPDB Length = 494 Score = 287 bits (734), Expect = 6e-78, Method: Composition-based stats. Identities = 86/268 (32%), Positives = 141/268 (52%), Gaps = 16/268 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + ++R+K LG+G++G V+L + K T A+KI+ K V L E +L+ ++ Sbjct: 37 EMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSN-SKLLEEVAVLKLLDH 95 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL F+D N Y+VME GGE+F + +F+E A Q++ YLH Sbjct: 96 PNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKH 155 Query: 162 DLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSKGY 216 ++++RDLKPENLL+ ++ I++ DFG + + + GT Y+APE++ K Y Sbjct: 156 NIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVLR-KKY 214 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLRN 272 ++ D W++GV+++ + AGYPPF +I K+ GK F S + S KDL++ Sbjct: 215 DEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQ 274 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 +LQ D +R H W Sbjct: 275 MLQFDSQRRI-----SAQQALEHPWIKE 297 >4FG9-A nrPDB Length = 320 Score = 287 bits (734), Expect = 7e-78, Method: Composition-based stats. Identities = 93/281 (33%), Positives = 149/281 (53%), Gaps = 18/281 (6%) Query: 32 ENPAQNTAH--LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT 89 E P A D ++ LGTG+F V+L + K T A+K + K+ + + Sbjct: 6 EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEG--SM 63 Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149 NE +L + P +V L+ ++ +LY++M+ V GGE+F + G ++E A Sbjct: 64 ENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIF 123 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLL---IDQQGYIQVTDFGFAKRVKGRT--WTLCGTPE 204 Q++ +YLH L +++RDLKPENLL +D+ I ++DFG +K + T CGTP Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPG 183 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS---- 260 Y+APE++ K Y+KAVD W++GV+ Y + GYPPF+ + +++E+I+ + F S Sbjct: 184 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWD 243 Query: 261 HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 S KD +R+L++ D KRF H W A Sbjct: 244 DISDSAKDFIRHLMEKDPEKRFTC-----EQALQHPWIAGD 279 >3H4J-B nrPDB Length = 336 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 82/268 (30%), Positives = 134/268 (50%), Gaps = 9/268 (3%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 A + H+ + +TLG GSFG+V L H +T A+K + +Q + K E Sbjct: 2 AISKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREIS 61 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 L+ + P ++KL +++ MV+EY GGE+F ++ R +E R + QI+ Sbjct: 62 YLKLLRHPHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICA 120 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIIL 212 EY H +++RDLKPENLL+D +++ DFG + + T CG+P Y APE+I Sbjct: 121 IEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIN 180 Query: 213 SKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 K Y VD W+ G+++Y M G PF + +++K+ S P S + L+R Sbjct: 181 GKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIR 240 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 ++ D +R + +I+ WF Sbjct: 241 RMIVADPMQRI-----TIQEIRRDPWFN 263 >3DFA-A nrPDB Length = 286 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 80/270 (29%), Positives = 137/270 (50%), Gaps = 16/270 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 +++ + LG GSFG V+ K + T +A+K+++K K K L E +L+ ++ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKAS-AKNKDTSTILREVELLKKLDH 80 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++KL +D+S+ Y+V E GGE+F + + RFSE A Q+ Y+H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 162 DLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSKGY 216 ++++RDLKPEN+L+ ++ I++ DFG + + + GT Y+APE++ Y Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-TY 199 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF--PSH--FSSDLKDLLRN 272 ++ D W+ GV++Y + +G PPF+ I +++ +GK F P S D KDL+R Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 +L + R H W Sbjct: 260 MLTFHPSLRI-----TATQCLEHPWIQKYS 284 >6C9D-A nrPDB Length = 459 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 99/313 (31%), Positives = 158/313 (50%), Gaps = 19/313 (6%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 H+ + KT+G G+F +V L +H TG A+KI+DK ++ ++ E RI Sbjct: 15 DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTS-LQKLFREVRI 73 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 ++ +N P +VKL + LY+VMEY GGE+F +L GR E AR QIV Sbjct: 74 MKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 133 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILS 213 +Y H +++RDLK ENLL+D I++ DFGF+ + CG+P Y APE+ Sbjct: 134 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQG 193 Query: 214 KGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 272 K Y+ VD W+LGV++Y + +G PF ++ E+++ GK R P + S+D ++LL+ Sbjct: 194 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 253 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD--- 329 LL ++ KR + I +W ++ + P+ DT D Sbjct: 254 LLVLNPIKR-----GSLEQIMKDRWM-----NVGHEEEELKPYTEPDPDFNDTKRIDIMV 303 Query: 330 --DYEEEEIRVSI 340 + +EI ++ Sbjct: 304 TMGFARDEINDAL 316 >3OHT-A nrPDB Length = 389 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 81/375 (21%), Positives = 160/375 (42%), Gaps = 38/375 (10%) Query: 2 GNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV 61 G+AAA S +E + + + WE P ++++ + +G+G++G V Sbjct: 21 GSAAAPFTMSHKERPTFYRQELNKTI---WEVP-------ERYQTLSPVGSGAYGSVCSS 70 Query: 62 KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF------KDNS 115 ++G A+K L + + + T E R+L+ + ++ L F ++ + Sbjct: 71 YDVKSGLKIAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFN 129 Query: 116 NLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI 175 ++Y+V + G +++ + + ++ H +F QI+ +Y+HS D+I+RDLKP NL + Sbjct: 130 DVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV 187 Query: 176 DQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAA 234 ++ +++ DFG A+ T Y APEI+L+ YN VD W++G ++ E+ Sbjct: 188 NEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLT 247 Query: 235 GYPPFFADQPIQIYEKIVSGKVRFPSHF-----SSDLKDLLR---NLLQVDLTKRFGNLK 286 G F I ++I+ P+ S + ++ + + + + F Sbjct: 248 GRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGAN 307 Query: 287 NGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE----------EEEI 336 D+ TD + P+ ++ P D + Y+ EE Sbjct: 308 PLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDPDDEPESEPYDQSFESRQLEIEEWK 367 Query: 337 RVSINEKCGKEFSEF 351 R++ E C E F Sbjct: 368 RLTYEEVCSFETPPF 382 >3SOA-A nrPDB Length = 444 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 80/287 (27%), Positives = 143/287 (49%), Gaps = 16/287 (5%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 T ++++ + LG G+F V G +A I++ +K+ + + E RI Sbjct: 6 CTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSA-RDHQKLEREARIC 64 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + + P +V+L S + + Y++ + V GGE+F + +SE A QI+ Sbjct: 65 RLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 124 Query: 157 YLHSLDLIYRDLKPENLLIDQQGY---IQVTDFGFAKRVKGRT---WTLCGTPEYLAPEI 210 + H + +++R+LKPENLL+ + +++ DFG A V+G + GTP YL+PE+ Sbjct: 125 HCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 184 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDL 266 + Y K VD WA GV++Y + GYPPF+ + ++Y++I +G FPS + + Sbjct: 185 LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 244 Query: 267 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 KDL+ +L ++ +KR + H W + +A + E Sbjct: 245 KDLINKMLTINPSKRI-----TAAEALKHPWISHRSTVASCMHRQET 286 >3DB8-A nrPDB Length = 317 Score = 283 bits (725), Expect = 7e-77, Method: Composition-based stats. Identities = 84/300 (28%), Positives = 149/300 (49%), Gaps = 11/300 (3%) Query: 4 AAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH 63 +AA K S + S K LK+ + + + ++ R + LG G F + + Sbjct: 7 SAAIAKPSAKPSAH---VDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITD 63 Query: 64 KETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEY 123 +T FA K++ K ++K Q E E I ++++ P +V F+D+ +Y+V+E Sbjct: 64 MDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEI 123 Query: 124 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 183 + +R +EP AR++ Q + +YLH+ +I+RDLK NL ++ +++ Sbjct: 124 CRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKI 183 Query: 184 TDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240 DFG A +++ R LCGTP Y+APE++ KG++ VD W+LG ++Y + G PPF Sbjct: 184 GDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFE 243 Query: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 + Y +I + P H + L+R +L D T L+ V ++ ++F + Sbjct: 244 TSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPT-----LRPSVAELLTDEFFTS 298 >4FR4-A nrPDB Length = 384 Score = 283 bits (725), Expect = 7e-77, Method: Composition-based stats. Identities = 101/315 (32%), Positives = 178/315 (56%), Gaps = 14/315 (4%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 + D FE ++ +G GSFG+V +V+ +T +AMK ++KQK V+ ++ + E Sbjct: 6 FDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKE 65 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 +I+Q + PFLV L YSF+D +++MV++ + GG++ HL++ F E + + ++V Sbjct: 66 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELV 125 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEI 210 + +YL + +I+RD+KP+N+L+D+ G++ +TDF A + T T+ GT Y+APE+ Sbjct: 126 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 185 Query: 211 ILSKG---YNKAVDWWALGVLIYEMAAGYPPFF---ADQPIQIYEKIVSGKVRFPSHFSS 264 S+ Y+ AVDWW+LGV YE+ G P+ + +I + V +PS +S Sbjct: 186 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQ 245 Query: 265 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGD 324 ++ LL+ LL+ + +RF L +D++N + +W A++Q+++ FIP Sbjct: 246 EMVSLLKKLLEPNPDQRFSQL----SDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNC 301 Query: 325 TSNFDDYEEEEIRVS 339 F+ EE I S Sbjct: 302 DPTFE--LEEMILES 314 >4D2V-A nrPDB Length = 356 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 93/281 (33%), Positives = 139/281 (49%), Gaps = 13/281 (4%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 L +E +T+GTG F +V L H TG A+KI+DK + + E L+ + Sbjct: 28 LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLR 85 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 + +L + + + ++MV+EY PGGE+F ++ R SE R QIV Y+HS Sbjct: 86 HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 145 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL----CGTPEYLAPEIILSKGY 216 +RDLKPENLL D+ +++ DFG + KG CG Y APE+I K Y Sbjct: 146 QGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSY 205 Query: 217 -NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 275 D W++G+L+Y + G+ PF D + KI+ GK P S LL+ +LQ Sbjct: 206 LGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQ 265 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFI 316 VD KR + ++ NH W D+ + + + PFI Sbjct: 266 VDPKKRI-----SMKNLLNHPWIMQ-DYNYPVEWQSKNPFI 300 >4JXF-A nrPDB Length = 266 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 83/265 (31%), Positives = 138/265 (52%), Gaps = 9/265 (3%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 ++ F+ LG GSF V + TG A+K++DK+ + K ++ NE +I + Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYL 158 P +++L F+D++ +Y+V+E GEM +L+ R+ FSE AR + QI+ YL Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKG 215 HS +++RDL NLL+ + I++ DFG A ++ + +TLCGTP Y++PEI Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA 184 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 275 + D W+LG + Y + G PPF D K+V PS S + KDL+ LL+ Sbjct: 185 HGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLR 244 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFAT 300 + R ++ + +H + + Sbjct: 245 RNPADRL-----SLSSVLDHPFMSR 264 >2JAM-A nrPDB Length = 304 Score = 281 bits (720), Expect = 2e-76, Method: Composition-based stats. Identities = 96/273 (35%), Positives = 148/273 (54%), Gaps = 16/273 (5%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 Q T F ++ LG+G+F V LVK + TG FA+K + K + +E NE + Sbjct: 3 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE---NEIAV 59 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ + +V LE ++ ++ Y+VM+ V GGE+F + G ++E A Q++ Sbjct: 60 LKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAV 119 Query: 156 EYLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAK-RVKGRTWTLCGTPEYLAPEII 211 +YLH +++RDLKPENLL ++ I +TDFG +K G T CGTP Y+APE++ Sbjct: 120 KYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVL 179 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF----SSDLK 267 K Y+KAVD W++GV+ Y + GYPPF+ + +++EKI G F S F S K Sbjct: 180 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 239 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 D + +LL+ D +R+ K +H W Sbjct: 240 DFICHLLEKDPNERYTCEK-----ALSHPWIDG 267 >4CQG-A nrPDB Length = 331 Score = 281 bits (720), Expect = 2e-76, Method: Composition-based stats. Identities = 91/280 (32%), Positives = 142/280 (50%), Gaps = 13/280 (4%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 L +E +T+GTG F +V L H TG A+KI+DK + + E L+++ Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALKSLR 65 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 + +L + + + ++MV+EY PGGE+F ++ R SE R QI+ Y+HS Sbjct: 66 HQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL----CGTPEYLAPEIILSKGY 216 +RDLKPENLL D+ +++ DFG + KG CG+ Y APE+I K Y Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSY 185 Query: 217 -NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 275 D W++G+L+Y + G+ PF D + +Y+KI+ GK P S LL+ +LQ Sbjct: 186 LGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQ 245 Query: 276 VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPF 315 VD KR + ++ NH W D+ + + + P Sbjct: 246 VDPKKRI-----SMRNLLNHPWVMQ-DYSCPVEWQSKTPL 279 >3COM-A nrPDB Length = 314 Score = 281 bits (719), Expect = 3e-76, Method: Composition-based stats. Identities = 80/289 (27%), Positives = 136/289 (47%), Gaps = 17/289 (5%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ 78 L LKK + + + F+ ++ LG GS+G V HKETG A+K + + Sbjct: 6 QLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE 65 Query: 79 KVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIG 137 ++ + E I+Q + P +VK S+ N++L++VMEY G + +R R Sbjct: 66 S-----DLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNK 120 Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--- 194 +E + EYLH + I+RD+K N+L++ +G+ ++ DFG A ++ Sbjct: 121 TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 180 Query: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254 + T+ GTP ++APE+I GYN D W+LG+ EMA G PP+ P++ I + Sbjct: 181 KRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN 240 Query: 255 K---VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 R P +S + D ++ L +R + H + + Sbjct: 241 PPPTFRKPELWSDNFTDFVKQCLVKSPEQR-----ATATQLLQHPFVRS 284 >5JZN-A nrPDB Length = 280 Score = 281 bits (719), Expect = 4e-76, Method: Composition-based stats. Identities = 91/269 (33%), Positives = 144/269 (53%), Gaps = 17/269 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++++ +T+G G+F V + T +A+KI+ K K + + NE IL+ V Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM--IQNEVSILRRVKH 76 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V L + LY+VME V GG++F + +++E A + +YLHSL Sbjct: 77 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSL 136 Query: 162 DLIYRDLKPENLLI----DQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYN 217 ++++RD+KPENLL+ D +++ DFG A V G +T+CGTP Y+APEII GY Sbjct: 137 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYG 196 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQ--IYEKIVSGKVRFPS----HFSSDLKDLLR 271 VD WA GV+ Y + G+PPF Q ++++I+ G+V FPS + S K+L+ Sbjct: 197 LKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELIT 256 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 +L VD+ +RF + H W Sbjct: 257 MMLLVDVDQRF-----SAVQVLEHPWVND 280 >4YHJ-A nrPDB Length = 584 Score = 280 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 100/316 (31%), Positives = 160/316 (50%), Gaps = 8/316 (2%) Query: 14 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK 73 E +E+ + +W+ + + F + LG G FG V + + TG +A K Sbjct: 157 EPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACK 216 Query: 74 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL 133 L K+++ K K LNEKRIL+ V F+V L Y+++ L +V+ + GG++ H+ Sbjct: 217 KLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHI 276 Query: 134 RRIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191 +G F E A FYAA++ E L ++YRDLKPEN+L+D +G+I+++D G A Sbjct: 277 YNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE 336 Query: 192 VKG--RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI---- 245 + R GT Y+APE++ ++ Y + DWW LG LIYEM G+ PF + Sbjct: 337 IPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWE 396 Query: 246 QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIA 305 ++ ++I + + FS D K + R LL + +KR G G +K H F ++ Sbjct: 397 EVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRR 456 Query: 306 IYQRKVEAPFIPKFKG 321 + +E PF P Sbjct: 457 LEANMLEPPFCPDPHA 472 >5WAX-A nrPDB Length = 310 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 79/268 (29%), Positives = 142/268 (52%), Gaps = 20/268 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D++E ++ +G+G+FG L++++ G A+K +++ + + E+ E +++ Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKID----ENVQREIINHRSLRH 66 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +++ + ++L +VMEY GGE+F + GRFSE ARF+ Q++ Y HS+ Sbjct: 67 PNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 162 DLIYRDLKPENLLIDQQG--YIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L K Y+ Sbjct: 127 QVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 186 Query: 218 KAV-DWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 270 V D W+ GV +Y M G PF + + K I+ + P H S + +DL+ Sbjct: 187 GKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQDLI 246 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + + R + +I+NH WF Sbjct: 247 SRIFVANPATRI-----TIPEIRNHPWF 269 >4YNZ-A nrPDB Length = 342 Score = 277 bits (709), Expect = 5e-75, Method: Composition-based stats. Identities = 87/268 (32%), Positives = 145/268 (54%), Gaps = 9/268 (3%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK 93 P + ++ + KTLG G G V L H T A+KI++++K+ + + E Sbjct: 2 PLGSMQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSE-SVLMKVEREI 60 Query: 94 RILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 IL+ + P ++KL +++ LY+V+E+V GGE+F +L + GR + AR + QI+ Sbjct: 61 AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIIS 120 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEII 211 ++ HS + +RDLKPENLL+D++ I++ DFG A G + T CG+P Y PE+I Sbjct: 121 ALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVI 180 Query: 212 LSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 270 + Y+ + D W+ GV+++ + G PF D Q+ EK+ G P D + LL Sbjct: 181 RGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLL 240 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 R +++VD +R + I+ H W+ Sbjct: 241 RGMIEVDAARRL-----TLEHIQKHIWY 263 >4JG6-A nrPDB Length = 355 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 99/299 (33%), Positives = 149/299 (49%), Gaps = 26/299 (8%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + D +E + +G GS+ HK T FA+KI+DK K ++IE Sbjct: 28 RNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIE------I 81 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 +L+ P ++ L+ + D +Y+V E + GGE+ + R FSE A I T Sbjct: 82 LLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKT 141 Query: 155 FEYLHSLDLIYRDLKPENLL-IDQQGY---IQVTDFGFAKRV---KGRTWTLCGTPEYLA 207 EYLH+ +++RDLKP N+L +D+ G I++ DFGFAK++ G T C T ++A Sbjct: 142 VEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVA 201 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPF---FADQPIQIYEKIVSGKVRFP----S 260 PE++ +GY+ A D W+LGVL+Y M GY PF D P +I +I SGK + Sbjct: 202 PEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWN 261 Query: 261 HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ-RKVEAPFIPK 318 S KDL+ +L VD +R + H W D + YQ + +AP + K Sbjct: 262 SVSDTAKDLVSKMLHVDPHQRLTAAL-----VLRHPWIVHWDQLPQYQLNRQDAPHLVK 315 >2YAB-A nrPDB Length = 361 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 79/292 (27%), Positives = 136/292 (46%), Gaps = 18/292 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ---IEHTLNEKRILQA 98 D ++ + LG+G F V + K TG +A K + K++ ++ E E IL+ Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQ 71 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 V P ++ L +++ +++ +++E V GGE+F L + SE A + QI+ YL Sbjct: 72 VLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 159 HSLDLIYRDLKPENLLIDQQG----YIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIIL 212 H+ + + DLKPEN+++ + +I++ DFG A ++ + GTPE++APEI+ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF----SSDLKD 268 + D W++GV+ Y + +G PF D + I + F F S KD Sbjct: 192 YEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKD 251 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFK 320 +R LL + KR + + H W D R+ + FK Sbjct: 252 FIRKLLVKETRKRL-----TIQEALRHPWITPVDTQQAMVRRESVVNLENFK 298 >4NIF-A nrPDB Length = 333 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 94/288 (32%), Positives = 146/288 (50%), Gaps = 25/288 (8%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 N D + +T+G GS+ HK T +A+K++DK K ++IE Sbjct: 1 GSNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE------I 54 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 +L+ P ++ L+ + D ++Y+V E + GGE+ + R FSE A F I T Sbjct: 55 LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKT 114 Query: 155 FEYLHSLDLIYRDLKPENLL-IDQQGY---IQVTDFGFAKRV---KGRTWTLCGTPEYLA 207 EYLHS +++RDLKP N+L +D+ G +++ DFGFAK++ G T C T ++A Sbjct: 115 VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 174 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPF---FADQPIQIYEKIVSGKVRFP----S 260 PE++ +GY++ D W+LG+L+Y M AGY PF +D P +I +I SGK + Sbjct: 175 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 234 Query: 261 HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ 308 S KDL+ +L VD +R + H W D + Q Sbjct: 235 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWVTQKDKLPQSQ 277 >6FDY-U nrPDB Length = 276 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 81/274 (29%), Positives = 143/274 (52%), Gaps = 14/274 (5%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVK-HKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 P LD F + LG+G++ V K+T A+K + K+ + K +E+ L E Sbjct: 3 PGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKAS-VENLLTE 61 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 IL+ + P +V+L+ D+ N+Y++ME+ GG++ + E AR + Q+ Sbjct: 62 IEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLA 121 Query: 153 LTFEYLHSLDLIYRDLKPENLLID--QQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAP 208 ++LH ++ + DLKP+N+L+ ++ ++++ DFGFA+ + L G+P Y+AP Sbjct: 122 SALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAP 181 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK---VRFPSHFSSD 265 E++ + Y+ VD W++GV++YE G PPF + ++ EKI S + + S D Sbjct: 182 EMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRD 241 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 +DLL+ LL+ D ++R D H W Sbjct: 242 CRDLLQRLLERDPSRRI-----SFQDFFAHPWVD 270 >4I6B-A nrPDB Length = 308 Score = 274 bits (700), Expect = 5e-74, Method: Composition-based stats. Identities = 80/267 (29%), Positives = 132/267 (49%), Gaps = 8/267 (2%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 + ++ R KTLG G F + + +A KI+ +V K Q E E + Sbjct: 23 DPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELH 82 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + ++ +V+ + F+D N+Y+++EY M L+ +EP R+Y QIV + Sbjct: 83 RILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLK 142 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILS 213 YLH ++++RDLK N I++ ++V DFG A R++ R T+CGTP YL+PE++ Sbjct: 143 YLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNK 202 Query: 214 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 +G+ D WALG ++Y M G PPF + Y I + PS + K L+ ++ Sbjct: 203 QGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASM 262 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFAT 300 L + R ++DI H +F Sbjct: 263 LSKNPEDR-----PSLDDIIRHDFFTQ 284 >4CSV-A nrPDB Length = 275 Score = 273 bits (699), Expect = 7e-74, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 114/266 (42%), Gaps = 18/266 (6%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 KWE P + + LG+G FG V K + A+K L + + +E Sbjct: 4 DKWEIPRS------EITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS----VEE 53 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARF 146 L E +I++ + P LV+L +Y++ EY+ G + +LR + Sbjct: 54 FLQEAQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLD 113 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP--- 203 AAQ+ YL S + I+RDL N L+ + ++V DFG A+ + +T Sbjct: 114 MAAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFP 173 Query: 204 -EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPS 260 ++ APE I ++ D WA G+L++E+ G P+ ++ E++ G ++ P Sbjct: 174 IKWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQ 233 Query: 261 HFSSDLKDLLRNLLQVDLTKRFGNLK 286 ++ +L+ +R + Sbjct: 234 GCPEEIYELMLQCWNKSPEERPTFAE 259 >4C0T-A nrPDB Length = 974 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 92/297 (30%), Positives = 164/297 (55%), Gaps = 19/297 (6%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 ++ F+ K LG GS+ V+L K TG +A+K+LDK+ ++K K++++ EK L Sbjct: 262 RRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALN 321 Query: 98 AVNFP-FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 ++ ++ L ++F+D +LY V++Y GE+ + ++R +E R + AQI+ + Sbjct: 322 RLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG------------RTWTLCGTPE 204 Y+H +I+RDLKPEN+L+D + IQ+TDFG A+ ++ R + GT E Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSS 264 Y++PE++ +K K D WA G +IY+M AG PPF A ++KI + F + F + Sbjct: 442 YVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPT 501 Query: 265 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ-RKVEAPFIPKFK 320 ++DL++ +L + ++R + +I+ H +F + D+ + P I +K Sbjct: 502 IIRDLIKKILVLQPSRR-----ATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYK 553 >4B8L-A nrPDB Length = 286 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 81/268 (30%), Positives = 137/268 (51%), Gaps = 6/268 (2%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 +D F+ + LG G FG V L + K+ A+K+L K ++ K E I + Sbjct: 13 TIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHL 72 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 P ++++ F D +Y+++E+ P GE++ L++ GRF E + + ++ Y H Sbjct: 73 RHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCH 132 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-RTWTLCGTPEYLAPEIILSKGYNK 218 +I+RD+KPENLL+ +G +++ DFG++ R T+CGT +YL PE+I K +++ Sbjct: 133 ERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDE 192 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278 VD W GVL YE G PPF + + + +IV+ ++FP S KDL+ LL+ Sbjct: 193 KVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHP 252 Query: 279 TKRFGNLKNGVNDIKNHKWFATTDWIAI 306 +R + + H W + Sbjct: 253 PQRLP-----LKGVMEHPWVKANSRRVL 275 >3Q5I-A nrPDB Length = 504 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 81/279 (29%), Positives = 140/279 (50%), Gaps = 25/279 (8%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVK----------LKQIEHTLN 91 + + +++ LG+G++G V+L K K + A+K++ K + K K E N Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 92 EKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151 E +L++++ P ++KL F+D Y+V E+ GGE+F + +F E A QI Sbjct: 96 EISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQI 155 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQG---YIQVTDFGFAKRVKG--RTWTLCGTPEYL 206 + YLH ++++RD+KPEN+L++ + I++ DFG + + GT Y+ Sbjct: 156 LSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYI 215 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHF 262 APE++ K YN+ D W+ GV++Y + GYPPF I +K+ GK F + Sbjct: 216 APEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNI 274 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 S + K+L++ +L D KR + N +W Sbjct: 275 SDEAKELIKLMLTYDYNKRC-----TAEEALNSRWIKKY 308 >5XZW-A nrPDB Length = 471 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 93/292 (31%), Positives = 146/292 (50%), Gaps = 31/292 (10%) Query: 34 PAQNTAHLDQFERI-KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 A T F I + +G G+F V + TG FA+KI+ K+KV+ ++ E Sbjct: 187 VANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIG--NMDGVTRE 244 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 +LQ +N P +V+L+ ++D + YMVME+V GG++ + G E R + QI+ Sbjct: 245 LEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQIL 304 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGY--IQVTDFGFAKRVKGR---TWTLCGTPEYLA 207 +Y+HS+ + +RDLKP+N+LI+Q +++TDFG AK V+G T CGT Y+A Sbjct: 305 TAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAK-VQGNGSFMKTFCGTLAYVA 363 Query: 208 PEIILSKG-------------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254 PE+I K Y+ VD W++G L+Y + G+ PF Q+Y++I G Sbjct: 364 PEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG 423 Query: 255 KVR----FPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 S + +D + +LLQVD R + NH W + Sbjct: 424 SYHEGPLKDFRISEEARDFIDSLLQVDPNNR-----STAAKALNHPWIVDSS 470 >4B6L-A nrPDB Length = 281 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 76/259 (29%), Positives = 127/259 (49%), Gaps = 8/259 (3%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + + + LG G F R ETG+ +A+K++ + +V K Q E LNE + + + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 +V+ + F+D N+Y+ +E + + EP R+Y QI+ +YLH + Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 130 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAV 220 ++RDLK N I + ++V DFG A R++ R T+CGTP Y+APE++L +G+ Sbjct: 131 LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEA 190 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 280 D W+LG ++Y + G PPF + Y I P+ S + LL +L+ Sbjct: 191 DVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRD 250 Query: 281 RFGNLKNGVNDIKNHKWFA 299 R ++ I H +F Sbjct: 251 R-----PSIDQILRHDFFT 264 >3ZUT-A nrPDB Length = 362 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 80/268 (29%), Positives = 144/268 (53%), Gaps = 20/268 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D++E +K +G+G+FG L++ K++ A+K +++ + + E+ E +++ Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID----ENVKREIINHRSLRH 74 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+ + ++L +VMEY GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 Query: 162 DLIYRDLKPENLLIDQQ--GYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 + +RDLK EN L+D +++ FG++K + + + GTP Y+APE++L K Y+ Sbjct: 135 QVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 Query: 218 KAV-DWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 270 V D W+ GV +Y M G PF + + + K I++ + P H S + + L+ Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + D KR + +I+NH+WF Sbjct: 255 SRIFVADPAKRI-----SIPEIRNHEWF 277 >6FD3-A nrPDB Length = 300 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 72/285 (25%), Positives = 138/285 (48%), Gaps = 15/285 (5%) Query: 21 AKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKV 80 + E+ L+K + ++ R + +G G+ G V TG A+K ++ Q+ Sbjct: 1 SMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQ 60 Query: 81 VKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140 K E +NE +++ P +V S+ L++VMEY+ GG + + Sbjct: 61 PKK---ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MD 116 Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTW 197 E + + ++LHS +I+RD+K +N+L+ G +++TDFGF ++ + + Sbjct: 117 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 176 Query: 198 TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--- 254 T+ GTP ++APE++ K Y VD W+LG++ EM G PP+ + P++ I + Sbjct: 177 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 236 Query: 255 KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 +++ P S+ +D L L++D+ +R ++ H + Sbjct: 237 ELQNPERLSAVFRDFLNRCLEMDVDRR-----GSAKELLQHPFLK 276 >2J90-A nrPDB Length = 304 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 74/282 (26%), Positives = 130/282 (46%), Gaps = 18/282 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ---IEHTLNEKRILQA 98 D +E + LG+G F V + K TG +A K + K+++ ++ E E IL+ Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + P ++ L F++ +++ +++E V GGE+F L +E A + QI+ YL Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 145 Query: 159 HSLDLIYRDLKPENLLIDQQG----YIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIIL 212 HS + + DLKPEN+++ + I++ DFG A +++ + GTPE++APEI+ Sbjct: 146 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVN 205 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF----SSDLKD 268 + D W++GV+ Y + +G PF + + I + F + S KD Sbjct: 206 YEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKD 265 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRK 310 +R LL D +R + H W + Sbjct: 266 FIRRLLVKDPKRRM-----TIAQSLEHSWIKAIRRRNVRGED 302 >3UC3-A nrPDB Length = 361 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 79/268 (29%), Positives = 137/268 (51%), Gaps = 20/268 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D+++ +K +G+G+FG L++ K T A+K +++ + E+ E +++ Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID----ENVQREIINHRSLRH 75 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+ + ++L ++MEY GGE++ + GRFSE ARF+ Q++ Y HS+ Sbjct: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 Query: 162 DLIYRDLKPENLLIDQQ--GYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L + Y+ Sbjct: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 Query: 218 KA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 270 D W+ GV +Y M G PF + + Y K I+S K P S + L+ Sbjct: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + D R + +IK H WF Sbjct: 256 SRIFVADPATRI-----SIPEIKTHSWF 278 >2W4O-A nrPDB Length = 349 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 87/280 (31%), Positives = 140/280 (50%), Gaps = 20/280 (7%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 W + + A D FE LG G+ V K K T +A+K+L K K+ Sbjct: 42 WIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI-----VR 96 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 E +L ++ P ++KL+ F+ + + +V+E V GGE+F + G +SE A Q Sbjct: 97 TEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQ 156 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQ---QGYIQVTDFGFAKRVKGR--TWTLCGTPEY 205 I+ YLH +++RDLKPENLL +++ DFG +K V+ + T+CGTP Y Sbjct: 157 ILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGY 216 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ-IYEKIVSGKVRF--P--S 260 APEI+ Y VD W++G++ Y + G+ PF+ ++ Q ++ +I++ + F P Sbjct: 217 CAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD 276 Query: 261 HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 S + KDL+R L+ +D KR + H W Sbjct: 277 EVSLNAKDLVRKLIVLDPKKRLTTFQ-----ALQHPWVTG 311 >3GUB-A nrPDB Length = 295 Score = 270 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 132/290 (45%), Gaps = 18/290 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ---IEHTLNEKRILQA 98 D ++ + LG+G F V + K TG +A K + K++ ++ E E IL+ Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 + P ++ L +++ +++ ++ E V GGE+F L +E A + QI+ YL Sbjct: 71 IQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130 Query: 159 HSLDLIYRDLKPENLLIDQQG----YIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIIL 212 HSL + + DLKPEN+++ + I++ DFG A ++ + GTPE++APEI+ Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVN 190 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF----SSDLKD 268 + D W++GV+ Y + +G PF D + + + F + S+ KD Sbjct: 191 YEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKD 250 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 318 +R LL D KR + D H W D P K Sbjct: 251 FIRRLLVKDPKKRM-----TIQDSLQHPWIKPKDTQQALSSAWSHPQFEK 295 >4LG4-A nrPDB Length = 299 Score = 270 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 75/273 (27%), Positives = 131/273 (47%), Gaps = 17/273 (6%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + + F+ ++ LG GS+G V HKE+G A+K + + ++ + E Sbjct: 4 SLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES-----DLQEIIKEIS 58 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVL 153 I+Q + P++VK S+ N++L++VMEY G + +R R E + Sbjct: 59 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 118 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEI 210 EYLH + I+R++K N+L++ +G+ ++ DFG A ++ + T+ GTP ++APE+ Sbjct: 119 GLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 178 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK---VRFPSHFSSDLK 267 I GYN D W+LG+ EMA G PP+ P++ I + R P +S D Sbjct: 179 IQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFT 238 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 D ++ L + +R + H + Sbjct: 239 DFVKKCLVKNPEQR-----ATATQLLQHPFIKN 266 >3UDB-A nrPDB Length = 317 Score = 270 bits (690), Expect = 7e-73, Method: Composition-based stats. Identities = 81/268 (30%), Positives = 143/268 (53%), Gaps = 20/268 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D++E +K +G G+FG L++ K+ A+K +++ + + E+ E +++ Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKID----ENVKREIINHRSLRH 74 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V+ + ++L +VMEY GGE+F + GRFSE ARF+ Q++ Y H++ Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 162 DLIYRDLKPENLLIDQQ--GYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYN 217 + +RDLK EN L+D +++ DFG++K + + + GTP Y+APE++L K Y+ Sbjct: 135 QVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYD 194 Query: 218 KAV-DWWALGVLIYEMAAGYPPFFADQPIQIYEK----IVSGKVRFPS--HFSSDLKDLL 270 V D W+ GV +Y M G PF + + + K I++ + P H S + + L+ Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + D KR + +I+NH+WF Sbjct: 255 SRIFVADPAKRI-----SIPEIRNHEWF 277 >2A27-A nrPDB Length = 321 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 137/300 (45%), Gaps = 18/300 (6%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ---IEHTL 90 P + D ++ + LG+G F V + K TG +A K + K++ ++ E Sbjct: 4 PFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIE 63 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 E IL+ V ++ L +++ +++ +++E V GGE+F L + SE A + Q Sbjct: 64 REVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQG----YIQVTDFGFAKRVKG--RTWTLCGTPE 204 I+ YLH+ + + DLKPEN+++ + +I++ DFG A ++ + GTPE Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF-- 262 ++APEI+ + D W++GV+ Y + +G PF D + I + F F Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFS 243 Query: 263 --SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFK 320 S KD +R LL + KR + + H W D R+ + F+ Sbjct: 244 QTSELAKDFIRKLLVKETRKRL-----TIQEALRHPWITPVDNQQAMVRRESVVNLENFR 298 >4AF3-A nrPDB Length = 292 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 84/276 (30%), Positives = 141/276 (51%), Gaps = 12/276 (4%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 +D FE + LG G FG V L + K++ A+K+L K ++ K E I + Sbjct: 21 TIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL 80 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 + P +++L F D +Y+++EY P GE++ L++ F E ++ Y H Sbjct: 81 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 140 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-RTWTLCGTPEYLAPEIILSKGYNK 218 +I+RD+KPENLL+ +G +++ DFG++ R T+CGT +YL PE+I + +N+ Sbjct: 141 GKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNE 200 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 278 VD W +GVL YE+ G PPF + + Y +IV ++FP+ + +DL+ LL+ + Sbjct: 201 KVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHNP 260 Query: 279 TKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAP 314 ++R + H W R+V P Sbjct: 261 SERLPLAQVSA-----HPWVRA------NSRRVLPP 285 >3F3Z-A nrPDB Length = 277 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 79/265 (29%), Positives = 130/265 (49%), Gaps = 18/265 (6%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + T+G GS+G V + K T A K + K ++ ++ E I+++++ P Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPK---YFVEDVDRFKQEIEIMKSLDHPN 67 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 +++L +F+DN+++Y+VME GGE+F + F E A ++ Y H L++ Sbjct: 68 IIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127 Query: 164 IYRDLKPENLLI---DQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSKGYNK 218 +RDLKPEN L +++ DFG A R K T GTP Y++P+++ Y Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG-LYGP 186 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLRNLL 274 D W+ GV++Y + GYPPF A ++ KI G FP + S + L+R LL Sbjct: 187 ECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRRLL 246 Query: 275 QVDLTKRFGNLKNGVNDIKNHKWFA 299 +R +L+ H+WF Sbjct: 247 TKSPKQRITSLQ-----ALEHEWFE 266 >6AO5-A nrPDB Length = 362 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 75/273 (27%), Positives = 131/273 (47%), Gaps = 17/273 (6%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + + F+ ++ LG GS+G V HKE+G A+K + + ++ + E Sbjct: 3 SLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES-----DLQEIIKEIS 57 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVL 153 I+Q + P++VK S+ N++L++VMEY G + +R R E + Sbjct: 58 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 117 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEI 210 EYLH + I+R++K N+L++ +G+ ++ DFG A ++ + T+ GTP ++APE+ Sbjct: 118 GLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 177 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK---VRFPSHFSSDLK 267 I GYN D W+LG+ EMA G PP+ P++ I + R P +S D Sbjct: 178 IQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFT 237 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 D ++ L + +R + H + Sbjct: 238 DFVKKCLVKNPEQR-----ATATQLLQHPFIKN 265 >2OU7-A nrPDB Length = 335 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 80/254 (31%), Positives = 133/254 (52%), Gaps = 8/254 (3%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G F + + +T FA KI+ K ++K Q E E I +++ +V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 169 F+DN +++V+E + +R +EP AR+Y QIVL +YLH +I+RDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 170 PENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG 226 NL +++ +++ DFG A +V+ R LCGTP Y+APE++ KG++ VD W++G Sbjct: 169 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIG 228 Query: 227 VLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLK 286 ++Y + G PPF + Y +I + P H + L++ +LQ D T R Sbjct: 229 CIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR----- 283 Query: 287 NGVNDIKNHKWFAT 300 +N++ N ++F + Sbjct: 284 PTINELLNDEFFTS 297 >1ZWS-A nrPDB Length = 288 Score = 267 bits (683), Expect = 6e-72, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 134/290 (46%), Gaps = 18/290 (6%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ---IEHTL 90 P + D ++ + LG+G F V + K TG +A K + K++ ++ E Sbjct: 4 PFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIE 63 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 E IL+ V ++ L +++ +++ +++E V GGE+F L + SE A + Q Sbjct: 64 REVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQG----YIQVTDFGFAKRVKG--RTWTLCGTPE 204 I+ YLH+ + + DLKPEN+++ + +I++ DFG A ++ + GTPE Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF-- 262 ++APEI+ + D W++GV+ Y + +G PF D + I S F F Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFS 243 Query: 263 --SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRK 310 S KD +R LL + KR + + H W D R+ Sbjct: 244 HTSELAKDFIRKLLVKETRKRL-----TIQEALRHPWITPVDNQQAMVRR 288 >2YCR-A nrPDB Length = 323 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 103/308 (33%), Positives = 160/308 (51%), Gaps = 28/308 (9%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIE-----HTLNEKRIL 96 D++ KTLG+G+ G V L ++T A+KI+ K+K E + E IL Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + +N P ++K++ F D + Y+V+E + GGE+F + R E + Y Q++L + Sbjct: 70 KKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 157 YLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEII 211 YLH +I+RDLKPEN+L+ ++ I++TDFG +K + TLCGTP YLAPE++ Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 188 Query: 212 LS---KGYNKAVDWWALGVLIYEMAAGYPPF-FADQPIQIYEKIVSGKVRF-PS---HFS 263 +S GYN+AVD W+LGV+++ +GYPPF + + ++I SGK F P S Sbjct: 189 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVS 248 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD----WIAIYQRKVEAPFIPKF 319 DL++ LL VD RF + H W D + + + E+ P+ Sbjct: 249 EKALDLVKKLLVVDPKARFTT-----EEALRHPWLQDEDMKRKFQDLLSEENESTAKPQV 303 Query: 320 KGPGDTSN 327 TS Sbjct: 304 LAQPSTSR 311 >4J52-A nrPDB Length = 293 Score = 265 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 80/254 (31%), Positives = 133/254 (52%), Gaps = 8/254 (3%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG G F + + +T FA KI+ K ++K Q E E I +++ +V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 169 F+DN +++V+E + +R +EP AR+Y QIVL +YLH +I+RDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 170 PENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG 226 NL +++ +++ DFG A +V+ R LCGTP Y+APE++ KG++ VD W++G Sbjct: 142 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIG 201 Query: 227 VLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLK 286 ++Y + G PPF + Y +I + P H + L++ +LQ D T R Sbjct: 202 CIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR----- 256 Query: 287 NGVNDIKNHKWFAT 300 +N++ N ++F + Sbjct: 257 PTINELLNDEFFTS 270 >3TAC-A nrPDB Length = 361 Score = 264 bits (676), Expect = 4e-71, Method: Composition-based stats. Identities = 81/295 (27%), Positives = 138/295 (46%), Gaps = 25/295 (8%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI--EHTLNEK 93 + D +E + +G G F V ++ETG FA+KI+D K + E E Sbjct: 20 DDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREA 79 Query: 94 RILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR----FSEPHARFYAA 149 I + P +V+L ++ + LYMV E++ G ++ + + +SE A Y Sbjct: 80 SICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMR 139 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVKGR---TWTLCGTP 203 QI+ Y H ++I+RD+KP +L+ + +++ FG A ++ GTP Sbjct: 140 QILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTP 199 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS--- 260 ++APE++ + Y K VD W GV+++ + +G PF+ +++E I+ GK + Sbjct: 200 HFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQW 258 Query: 261 -HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAP 314 H S KDL+R +L +D +R V + NH W D Y K+ P Sbjct: 259 SHISESAKDLVRRMLMLDPAERI-----TVYEALNHPWLKERDR---YAYKIHLP 305 >4FIE-A nrPDB Length = 423 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 139/293 (47%), Gaps = 18/293 (6%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHF 70 S Q + + L+ +P ++LD F +G GS G V + + +G Sbjct: 123 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLV 179 Query: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMF 130 A+K +D + K ++ E NE I++ +V++ S+ L++VME++ GG + Sbjct: 180 AVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALT 236 Query: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 190 + R +E ++ LH+ +I+RD+K +++L+ G ++++DFGF Sbjct: 237 D-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 295 Query: 191 RVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 +V R +L GTP ++APE+I Y VD W+LG+++ EM G PP+F + P++ Sbjct: 296 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 355 Query: 248 YEKIVSG---KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 + I +++ S LK L LL D +R ++ H + Sbjct: 356 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR-----ATAAELLKHPF 403 >4PDS-A nrPDB Length = 347 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 91/289 (31%), Positives = 144/289 (49%), Gaps = 31/289 (10%) Query: 34 PAQNTAHLDQFERI-KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 A T F I + +G G+F V + TG F++KI+ K+KV+ ++ E Sbjct: 22 VANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIG--NMDGVTRE 79 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 +LQ +N P +V+L+ ++D + YMVME+V GG++ + G E R + QI+ Sbjct: 80 LEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQIL 139 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGY--IQVTDFGFAKRVKGR---TWTLCGTPEYLA 207 +Y+HS+ + +RDLKP+N+LI+Q +++T FG AK V+G T CGT Y+A Sbjct: 140 TAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAK-VQGNGSFMKTFCGTLAYVA 198 Query: 208 PEIILSKG-------------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254 PE+I K Y+ VD W++G L+Y + G+ PF Q+Y++I G Sbjct: 199 PEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG 258 Query: 255 KVR----FPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 S + +D + +LLQVD R + NH W Sbjct: 259 SYHEGPLKDFRISEEARDFIDSLLQVDPNNR-----STAAKALNHPWIK 302 >6CMJ-A nrPDB Length = 321 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 92/283 (32%), Positives = 141/283 (49%), Gaps = 24/283 (8%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ--------IE 87 Q+ LDQ+ +G GS+G V L ++ ++AMK+L K+K+++ IE Sbjct: 28 QDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIE 87 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKD--NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 145 E IL+ ++ P +VKL D +LYMV E V G + + + SE AR Sbjct: 88 QVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQAR 146 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT---WTLCGT 202 FY ++ EYLH +I+RD+KP NLL+ + G+I++ DFG + KG GT Sbjct: 147 FYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGT 206 Query: 203 PEYLAPEIILSKG---YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP 259 P ++APE + KA+D WA+GV +Y G PF ++ + ++ KI S + FP Sbjct: 207 PAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFP 266 Query: 260 --SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 + DLKDL+ +L + R V +IK H W Sbjct: 267 DQPDIAEDLKDLITRMLDKNPESRIV-----VPEIKLHPWVTR 304 >3Q53-A nrPDB Length = 306 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 73/284 (25%), Positives = 139/284 (48%), Gaps = 15/284 (5%) Query: 22 KAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVV 81 + E+ L+K + ++ R + +G G+ G V TG A++ ++ Q+ Sbjct: 1 MSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQP 60 Query: 82 KLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE 141 K E +NE +++ P +V S+ L++VMEY+ GG + + E Sbjct: 61 KK---ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDE 116 Query: 142 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWT 198 + + E+LHS +I+RD+K +N+L+ G +++TDFGF ++ + + T Sbjct: 117 GQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 176 Query: 199 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---K 255 + GTP ++APE++ K Y VD W+LG++ EM G PP+ + P++ I + + Sbjct: 177 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPE 236 Query: 256 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 ++ P S+ +D L L++D+ KR ++ H++ Sbjct: 237 LQNPEKLSAIFRDFLNRCLEMDVEKR-----GSAKELIQHQFLK 275 >3GC9-A nrPDB Length = 370 Score = 263 bits (672), Expect = 9e-71, Method: Composition-based stats. Identities = 78/359 (21%), Positives = 147/359 (40%), Gaps = 30/359 (8%) Query: 10 GSEQESVKEFLAKAKEDFLKK--WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETG 67 GS + A L K WE P + + ++ +G+G++G V Sbjct: 1 GSHMLEMSGPRAGFYRQELNKTVWEVP-------QRLQGLRPVGSGAYGSVCSAYDARLR 53 Query: 68 NHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF------KDNSNLYMVM 121 A+K L + L T E R+L+ + ++ L F +D S +Y+V Sbjct: 54 QKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVT 112 Query: 122 EYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI 181 + G +++ + S+ H +F Q++ +Y+HS +I+RDLKP N+ +++ + Sbjct: 113 TLM--GADLNNIVKSQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSEL 170 Query: 182 QVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF 240 ++ DFG A++ T Y APEI+L+ YN+ VD W++G ++ E+ G F Sbjct: 171 RILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFP 230 Query: 241 ADQPIQIYEKIVSGKVRFPSHF-----SSDLKDLLRN---LLQVDLTKRFGNLKNGVNDI 292 I ++I+ S + +++ + Q DL+ F D+ Sbjct: 231 GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDL 290 Query: 293 KNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351 +D + + ++ P D + Y+E V E+ +E+ E Sbjct: 291 LGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDES---VEAKERTLEEWKEL 346 >2Q0N-A nrPDB Length = 301 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 139/293 (47%), Gaps = 18/293 (6%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHF 70 S Q + + L+ +P ++LD F +G GS G V + + +G Sbjct: 1 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLV 57 Query: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMF 130 A+K +D + K ++ E NE I++ +V++ S+ L++VME++ GG + Sbjct: 58 AVKKMDLR---KQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALT 114 Query: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 190 + R +E ++ LH+ +I+RD+K +++L+ G ++++DFGF Sbjct: 115 D-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 173 Query: 191 RVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 +V R +L GTP ++APE+I Y VD W+LG+++ EM G PP+F + P++ Sbjct: 174 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 233 Query: 248 YEKIVSG---KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 + I +++ S LK L LL D +R ++ H + Sbjct: 234 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR-----ATAAELLKHPF 281 >4JDH-A nrPDB Length = 346 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 139/293 (47%), Gaps = 18/293 (6%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHF 70 S Q + + L+ +P ++LD F +G GS G V + + +G Sbjct: 46 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLV 102 Query: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMF 130 A+K +D + K ++ E NE I++ +V++ S+ L++VME++ GG + Sbjct: 103 AVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALT 159 Query: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 190 + R +E ++ LH+ +I+RD+K +++L+ G ++++DFGF Sbjct: 160 D-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 218 Query: 191 RVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 +V R +L GTP ++APE+I Y VD W+LG+++ EM G PP+F + P++ Sbjct: 219 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 278 Query: 248 YEKIVSG---KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 + I +++ S LK L LL D +R ++ H + Sbjct: 279 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR-----ATAAELLKHPF 326 >4EWQ-A nrPDB Length = 383 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 71/371 (19%), Positives = 153/371 (41%), Gaps = 38/371 (10%) Query: 6 AAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKE 65 + + QE + + + WE P ++++ + +G+G++G V + Sbjct: 19 YFQSNASQERPTFYRQELNKTI---WEVP-------ERYQNLSPVGSGAYGSVCAAFDTK 68 Query: 66 TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF------KDNSNLYM 119 TG A+K L + + + T E R+L+ + ++ L F ++ +++Y+ Sbjct: 69 TGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYL 127 Query: 120 VMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG 179 V + G +++ + + ++ H +F QI+ +Y+HS D+I+RDLKP NL +++ Sbjct: 128 VTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDC 185 Query: 180 YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPP 238 +++ DFG A+ T Y APEI+L+ YN+ VD W++G ++ E+ G Sbjct: 186 ELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTL 245 Query: 239 FFADQPIQIYEKIVSGKVRFPSHF-----SSDLKDLLR---NLLQVDLTKRFGNLKNGVN 290 F I + I+ + S ++ ++ + +++ F Sbjct: 246 FPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAV 305 Query: 291 DIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE----------EEEIRVSI 340 D+ +D + + + ++ P D D Y+ +E ++ Sbjct: 306 DLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTY 365 Query: 341 NEKCGKEFSEF 351 +E Sbjct: 366 DEVISFVPPPL 376 >2UV2-A nrPDB Length = 325 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 80/284 (28%), Positives = 147/284 (51%), Gaps = 20/284 (7%) Query: 28 LKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIE 87 +K++E+ ++ D +E I LG G+FG+V ++KET A K++D + +++E Sbjct: 23 MKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKS---EEELE 79 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-FSEPHARF 146 + E IL + + P +VKL +F +NL++++E+ GG + + + + R +E + Sbjct: 80 DYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQV 139 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA---KRVKGRTWTLCGTP 203 Q + YLH +I+RDLK N+L G I++ DFG + R R + GTP Sbjct: 140 VCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTP 199 Query: 204 EYLAPEIIL-----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--- 255 ++APE+++ + Y+ D W+LG+ + EMA PP P+++ KI + Sbjct: 200 YWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPT 259 Query: 256 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 + PS +SS+ KD L+ L+ ++ R+ + + H + Sbjct: 260 LAQPSRWSSNFKDFLKKCLEKNVDARWTT-----SQLLQHPFVT 298 >4XBR-A nrPDB Length = 366 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 139/293 (47%), Gaps = 18/293 (6%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHF 70 S Q + + L+ +P ++LD F +G GS G V + + +G Sbjct: 66 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLV 122 Query: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMF 130 A+K +D + K ++ E NE I++ +V++ S+ L++VME++ GG + Sbjct: 123 AVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALT 179 Query: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 190 + R +E ++ LH+ +I+RD+K +++L+ G ++++DFGF Sbjct: 180 D-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 238 Query: 191 RVK---GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 247 +V R +L GTP ++APE+I Y VD W+LG+++ EM G PP+F + P++ Sbjct: 239 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 298 Query: 248 YEKIVSG---KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 + I +++ S LK L LL D +R ++ H + Sbjct: 299 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR-----ATAAELLKHPF 346 >3I6U-A nrPDB Length = 419 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 99/285 (34%), Positives = 153/285 (53%), Gaps = 24/285 (8%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIE-----HTLNEKRIL 96 D++ KTLG+G+ G V L ++T A++I+ K+K E + E IL Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + +N P ++K++ F D + Y+V+E + GGE+F + R E + Y Q++L + Sbjct: 195 KKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 157 YLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEII 211 YLH +I+RDLKPEN+L+ ++ I++TDFG +K + TLCGTP YLAPE++ Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 313 Query: 212 LS---KGYNKAVDWWALGVLIYEMAAGYPPF-FADQPIQIYEKIVSGKVRF-PS---HFS 263 +S GYN+AVD W+LGV+++ +GYPPF + + ++I SGK F P S Sbjct: 314 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVS 373 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ 308 DL++ LL VD RF + H W D +Q Sbjct: 374 EKALDLVKKLLVVDPKARFTT-----EEALRHPWLQDEDMKRKFQ 413 >2Y7J-A nrPDB Length = 365 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 99/318 (31%), Positives = 157/318 (49%), Gaps = 29/318 (9%) Query: 4 AAAAKKGSEQESVKE---FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML 60 A A K Q E F + ED L W A +++ +G G V Sbjct: 56 AEAKKLNDAQPKGTENLYFQSMGPEDELPDW---AAAKEFYQKYDPKDVIGRGVSSVVRR 112 Query: 61 VKHKETGNHFAMKILD-KQKVVKLKQIEH----TLNEKRILQAV-NFPFLVKLEYSFKDN 114 H+ TG+ FA+KI++ + + +Q+E T E IL+ V P ++ L S++ + Sbjct: 113 CVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESS 172 Query: 115 SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLL 174 S +++V + + GE+F +L SE R ++ +LH+ ++++RDLKPEN+L Sbjct: 173 SFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENIL 232 Query: 175 IDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSK------GYNKAVDWWALG 226 +D I+++DFGF+ ++ + LCGTP YLAPEI+ GY K VD WA G Sbjct: 233 LDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACG 292 Query: 227 VLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF----SSDLKDLLRNLLQVDLTKRF 282 V+++ + AG PPF+ + I + I+ G+ +F S SS +KDL+ LLQVD R Sbjct: 293 VILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARL 352 Query: 283 GNLKNGVNDIKNHKWFAT 300 H +F Sbjct: 353 -----TAEQALQHPFFER 365 >2F57-A nrPDB Length = 317 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 75/273 (27%), Positives = 134/273 (49%), Gaps = 18/273 (6%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P +L F +G GS G V + K TG A+K +D + K ++ E NE Sbjct: 39 SPGDPREYLANFI---KIGEGSTGIVCIATEKHTGKQVAVKKMDLR---KQQRRELLFNE 92 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 I++ + +V + S+ L++VME++ GG + + R +E ++ Sbjct: 93 VVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVL 151 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPE 209 YLH+ +I+RD+K +++L+ G I+++DFGF +V + +L GTP ++APE Sbjct: 152 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 211 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS---GKVRFPSHFSSDL 266 +I Y VD W+LG+++ EM G PP+F + P+Q +I +V+ SS L Sbjct: 212 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 271 Query: 267 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 + L +L + ++R ++ H + Sbjct: 272 RGFLDLMLVREPSQR-----ATAQELLGHPFLK 299 >4KS7-A nrPDB Length = 292 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 73/273 (26%), Positives = 137/273 (50%), Gaps = 18/273 (6%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 LD + +G GS G V L + K +G A+K++D + K ++ E NE Sbjct: 19 GDPRLLLDSYV---KIGEGSTGIVCLAREKHSGRQVAVKMMDLR---KQQRRELLFNEVV 72 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 I++ +V++ S+ L+++ME++ GG + + R +E ++ Sbjct: 73 IMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQA 131 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEII 211 YLH+ +I+RD+K +++L+ G ++++DFGF ++ + +L GTP ++APE+I Sbjct: 132 LAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI 191 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS---GKVRFPSHFSSDLKD 268 Y VD W+LG+++ EM G PP+F+D P+Q +++ K++ S L+D Sbjct: 192 SRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRD 251 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 L +L D +R ++ +H + T Sbjct: 252 FLERMLVRDPQER-----ATAQELLDHPFLLQT 279 >5YV8-A nrPDB Length = 298 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 90/299 (30%), Positives = 141/299 (47%), Gaps = 39/299 (13%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ--------- 85 + + L+Q+ +G GS+G V L ++ ++AMK+L K+K+++ Sbjct: 6 SGDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRG 65 Query: 86 --------------IEHTLNEKRILQAVNFPFLVKLEYSFKD--NSNLYMVMEYVPGGEM 129 IE E IL+ ++ P +VKL D +LYMV E V G + Sbjct: 66 TRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV 125 Query: 130 FSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA 189 + + SE ARFY ++ EYLH +I+RD+KP NLL+ + G+I++ DFG + Sbjct: 126 ME-VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS 184 Query: 190 KRVKGRT---WTLCGTPEYLAPEIILSKG---YNKAVDWWALGVLIYEMAAGYPPFFADQ 243 KG GTP ++APE + KA+D WA+GV +Y G PF ++ Sbjct: 185 NEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDER 244 Query: 244 PIQIYEKIVSGKVRFP--SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 + ++ KI S + FP + DLKDL+ +L + R V +IK H W Sbjct: 245 IMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIV-----VPEIKLHPWVTR 298 >4QMW-A nrPDB Length = 310 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 125/272 (45%), Gaps = 12/272 (4%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F +++ +G GSFG V T A+KI+D ++ + E +L + P+ Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 88 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 + K S+ ++ L+++MEY+ GG L G E +I+ +YLHS Sbjct: 89 VTKYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSEKK 147 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAV 220 I+RD+K N+L+ + G +++ DFG A ++ + T GTP ++APE+I Y+ Sbjct: 148 IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKA 207 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS-HFSSDLKDLLRNLLQVDLT 279 D W+LG+ E+A G PP P+++ I ++S LK+ + L + + Sbjct: 208 DIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPS 267 Query: 280 KRFGNLKNGVNDIKNHKWFATTDWIAIYQRKV 311 + ++ HK+ Y ++ Sbjct: 268 -----FRPTAKELLKHKFILRNAKKTSYLTEL 294 >2BPM-A nrPDB Length = 309 Score = 257 bits (656), Expect = 6e-69, Method: Composition-based stats. Identities = 79/312 (25%), Positives = 129/312 (41%), Gaps = 42/312 (13%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 ++ F++++ +G G++G V ++K TG A+K + + + E +L Sbjct: 2 PLVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLL 60 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL--RRIGRFSEPHARFYAAQIVLT 154 + +N P +VKL + LY+V E++ ++ + + P + Y Q++ Sbjct: 61 KELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQG 119 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEII 211 + HS +++RDLKP+NLLI+ +G I++ DFG A+ V RT+T T Y APEI+ Sbjct: 120 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 179 Query: 212 LS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---------------- 254 L K Y+ AVD W+LG + EM F D I +I Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 239 Query: 255 --KVRFP-----------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 K FP D + LL +L D KR H +F Sbjct: 240 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 294 Query: 302 DWIAIYQRKVEA 313 + R Sbjct: 295 TKPVPHLRLERP 306 >1PHK-A nrPDB Length = 298 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 88/285 (30%), Positives = 142/285 (49%), Gaps = 24/285 (8%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK------QKVVKLKQIEHT 89 + +E + LG G V HK T +A+KI+D + E T Sbjct: 11 STHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREAT 70 Query: 90 LNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148 L E IL+ V+ P +++L+ +++ N+ ++V + + GE+F +L SE R Sbjct: 71 LKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIM 130 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYL 206 ++ LH L++++RDLKPEN+L+D I++TDFGF+ ++ + +CGTP YL Sbjct: 131 RALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190 Query: 207 APEIILSK------GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF-- 258 APEII GY K VD W+ GV++Y + AG PPF+ + + + I+SG +F Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 250 Query: 259 PSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 P +S +KDL+ L V KR+ + H +F Sbjct: 251 PEWDDYSDTVKDLVSRFLVVQPQKRY-----TAEEALAHPFFQQY 290 >4APC-A nrPDB Length = 350 Score = 256 bits (655), Expect = 9e-69, Method: Composition-based stats. Identities = 81/265 (30%), Positives = 139/265 (52%), Gaps = 12/265 (4%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++++ R++ +G GSFG+ +LVK E G + +K ++ ++ K+ E + E +L + Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSS-KEREESRREVAVLANMK 81 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYL 158 P +V+ SF++N +LY+VM+Y GG++F + F E + QI L +++ Sbjct: 82 HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHV 141 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT---WTLCGTPEYLAPEIILSKG 215 H +++RD+K +N+ + + G +Q+ DFG A+ + GTP YL+PEI +K Sbjct: 142 HDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKP 201 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS-HFSSDLKDLLRNLL 274 YN D WALG ++YE+ F A + KI+SG S H+S DL+ L+ L Sbjct: 202 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLF 261 Query: 275 QVDLTKRFGNLKNGVNDIKNHKWFA 299 + + R VN I + A Sbjct: 262 KRNPRDR-----PSVNSILEKGFIA 281 >2WQN-A nrPDB Length = 310 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 73/264 (27%), Positives = 121/264 (45%), Gaps = 11/264 (4%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 +K P L F K +G G F V G A+K + ++ K Sbjct: 19 QKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARAD 78 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR----FSEPHA 144 + E +L+ +N P ++K SF +++ L +V+E G++ ++ + E Sbjct: 79 CIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTV 138 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW---TLCG 201 Y Q+ E++HS +++RD+KP N+ I G +++ D G + +T +L G Sbjct: 139 WKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVG 198 Query: 202 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD--QPIQIYEKIVSGKVR-- 257 TP Y++PE I GYN D W+LG L+YEMAA PF+ D + +KI Sbjct: 199 TPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPL 258 Query: 258 FPSHFSSDLKDLLRNLLQVDLTKR 281 H+S +L+ L+ + D KR Sbjct: 259 PSDHYSEELRQLVNMCINPDPEKR 282 >5MJB-A nrPDB Length = 305 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 123/308 (39%), Gaps = 37/308 (12%) Query: 1 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML 60 MG+ E+V+EF + F+K + +G G FG V Sbjct: 1 MGHHHHHHGSDPNEAVREFAKEIDVSFVK----------------IEEVIGAGEFGEVYK 44 Query: 61 VKHKETGNH---FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNL 117 + K G A+K L KQ L+E I+ + +++LE + + Sbjct: 45 GRLKLPGKREIYVAIKTLK--AGYSEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPV 102 Query: 118 YMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 ++ E++ + S LR+ G+F+ I +YL ++ ++RDL N+L++ Sbjct: 103 MIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVN 162 Query: 177 QQGYIQVTDFGFAKRVKGRTWTLCGT--------PEYLAPEIILSKGYNKAVDWWALGVL 228 +V+DFG ++ ++ T T + APE I + + A D W+ G++ Sbjct: 163 SNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIV 222 Query: 229 IYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLK 286 ++E M+ G P++ + I ++ P + L L+ + Q D R Sbjct: 223 MWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSR----- 277 Query: 287 NGVNDIKN 294 +I N Sbjct: 278 PRFAEIVN 285 >4FZF-B nrPDB Length = 283 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 71/272 (26%), Positives = 124/272 (45%), Gaps = 12/272 (4%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F +++ +G GSFG V T A+KI+D ++ + E +L + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSY 67 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 + K S+ S L+++MEY+ GG LR G F E +I+ +YLHS Sbjct: 68 VTKYYGSYLKGSKLWIIMEYLGGGSALDLLR-AGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAV 220 I+RD+K N+L+ +QG +++ FG A ++ + T GTP ++APE+I Y+ Sbjct: 127 IHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA 186 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKI-VSGKVRFPSHFSSDLKDLLRNLLQVDLT 279 D W+LG+ E+A G PP P+++ I + F+ K+ + L D + Sbjct: 187 DIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPS 246 Query: 280 KRFGNLKNGVNDIKNHKWFATTDWIAIYQRKV 311 + ++ HK+ Y ++ Sbjct: 247 -----FRPTAKELLKHKFIVKNSKKTSYLTEL 273 >1CM8-A nrPDB Length = 367 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 70/331 (21%), Positives = 133/331 (40%), Gaps = 28/331 (8%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + ++ +G+G++G V TG A+K L + + E R+L+ + Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHEN 85 Query: 104 LVKLEYSFK------DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 ++ L F D ++ Y+VM ++ G L + + E +F Q++ Y Sbjct: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KGY 216 +H+ +I+RDLKP NL +++ +++ DFG A++ T Y APE+IL+ Y Sbjct: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRY 203 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF-----SSDLKDLLR 271 + VD W++G ++ EM G F + ++I+ P+ F S + K+ ++ Sbjct: 204 TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMK 263 Query: 272 NLLQ---VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN- 327 L + D N ++ + + P+ D Sbjct: 264 GLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQV 323 Query: 328 ------FDDYE---EEEIRVSINEKCGKEFS 349 FDD + +E RV+ E + Sbjct: 324 QKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 >6HXF-B nrPDB Length = 302 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 74/284 (26%), Positives = 147/284 (51%), Gaps = 20/284 (7%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT 89 ++E+ ++ + +E + LG G+FG+V K+KETG A K+++ + +++E Sbjct: 7 EYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKS---EEELEDY 63 Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-FSEPHARFYA 148 + E IL + P++VKL ++ + L++++E+ PGG + + + + R +EP + Sbjct: 64 IVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVC 123 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEY 205 Q++ +LHS +I+RDLK N+L+ +G I++ DFG + + + + GTP + Sbjct: 124 RQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYW 183 Query: 206 LAPEIILSK-----GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS---GKVR 257 +APE+++ + Y+ D W+LG+ + EMA PP P+++ KI + Sbjct: 184 MAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLL 243 Query: 258 FPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 PS +S + +D L+ L + R + H + ++ Sbjct: 244 TPSKWSVEFRDFLKIALDKNPETR-----PSAAQLLEHPFVSSI 282 >2XYN-A nrPDB Length = 292 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 67/262 (25%), Positives = 115/262 (43%), Gaps = 18/262 (6%) Query: 28 LKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIE 87 + KWE LG G +G V + K+ A+K L + + ++E Sbjct: 24 MDKWE------MERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM----EVE 73 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHAR 145 L E +++ + P LV+L Y+V EY+P G + +LR R + Sbjct: 74 EFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLL 133 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP-- 203 + A QI EYL + I+RDL N L+ + ++V DFG ++ + G T+T Sbjct: 134 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKF 193 Query: 204 --EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFP 259 ++ APE + ++ D WA GVL++E+A G P+ Q+Y+ + G ++ P Sbjct: 194 PIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP 253 Query: 260 SHFSSDLKDLLRNLLQVDLTKR 281 + +L+R + R Sbjct: 254 EGCPPKVYELMRACWKWSPADR 275 >5J5T-A nrPDB Length = 370 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 131/306 (42%), Gaps = 22/306 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + FE I+ +G+G++G V ++ TG A+K++ + ++ E +++ Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ---EIIMMKDCKH 60 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P +V S+ L++ ME+ GG + G SE + + + + YLHS Sbjct: 61 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 120 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEII---LSKG 215 ++RD+K N+L+ G++++ DFG + ++ + GTP ++APE+ G Sbjct: 121 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS-----HFSSDLKDLL 270 YN+ D WA+G+ E+A PP F P++ + + P +S+ + Sbjct: 181 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 240 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 + L + KR + H + ++ ++ P D FDD Sbjct: 241 KMALTKNPKKR-----PTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHD---FDD 292 Query: 331 YEEEEI 336 + E + Sbjct: 293 DDPEPL 298 >2XIK-A nrPDB Length = 294 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 70/272 (25%), Positives = 125/272 (45%), Gaps = 12/272 (4%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F ++ +G GSFG V T A+KI+D ++ + E +L + P+ Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 78 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 + + S+ ++ L+++MEY+ GG L + G E + +I+ +YLHS Sbjct: 79 ITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATILREILKGLDYLHSERK 137 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAV 220 I+RD+K N+L+ +QG +++ DFG A ++ + T GTP ++APE+I Y+ Sbjct: 138 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 197 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH-FSSDLKDLLRNLLQVDLT 279 D W+LG+ E+A G PP P+++ I S K+ + L D Sbjct: 198 DIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDP- 256 Query: 280 KRFGNLKNGVNDIKNHKWFATTDWIAIYQRKV 311 RF + ++ HK+ + ++ Sbjct: 257 -RF---RPTAKELLKHKFITRYTKKTSFLTEL 284 >3UTO-A nrPDB Length = 573 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 82/312 (26%), Positives = 130/312 (41%), Gaps = 35/312 (11%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 LD ++ + LGTG+FG V V + TGN+FA K + E E + + + Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETVRKEIQTMSVLR 212 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL-RRIGRFSEPHARFYAAQIVLTFEYLH 159 P LV L +F+D++ + M+ E++ GGE+F + + SE A Y Q+ ++H Sbjct: 213 HPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMH 272 Query: 160 SLDLIYRDLKPENLLID--QQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEIILSKG 215 + ++ DLKPEN++ + +++ DFG + + GT E+ APE+ K Sbjct: 273 ENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKP 332 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLR 271 D W++GVL Y + +G PF + + + S S S D KD +R Sbjct: 333 VGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIR 392 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331 LL D R ++ H W PG S Sbjct: 393 KLLLADPNTRM-----TIHQALEHPWLT------------------PGNAPGRDSQIPSS 429 Query: 332 EEEEIRVSINEK 343 +IR SI K Sbjct: 430 RYTKIRDSIKTK 441 >2FO0-A nrPDB Length = 495 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 114/272 (41%), Gaps = 23/272 (8%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 KWE LG G +G V K+ A+K L + + ++E Sbjct: 210 DKWE------MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEE 259 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--F 146 L E +++ + P LV+L Y++ E++ G + +LR R + Sbjct: 260 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLY 319 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP--- 203 A QI EYL + I+R+L N L+ + ++V DFG ++ + G T+T Sbjct: 320 MATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFP 379 Query: 204 -EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPS 260 ++ APE + ++ D WA GVL++E+A G P+ Q+YE + ++ P Sbjct: 380 IKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPE 439 Query: 261 HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 + +L+R Q + + R +I Sbjct: 440 GCPEKVYELMRACWQWNPSDR-----PSFAEI 466 >4XEY-B nrPDB Length = 408 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 114/272 (41%), Gaps = 23/272 (8%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 KWE LG G +G V K+ A+K L + + ++E Sbjct: 118 DKWE------MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEE 167 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--F 146 L E +++ + P LV+L Y++ E++ G + +LR R + Sbjct: 168 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLY 227 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP--- 203 A QI EYL + I+RDL N L+ + ++V DFG ++ + G T+T Sbjct: 228 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFP 287 Query: 204 -EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPS 260 ++ APE + ++ D WA GVL++E+A G P+ Q+YE + ++ P Sbjct: 288 IKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPE 347 Query: 261 HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 + +L+R Q + + R +I Sbjct: 348 GCPEKVYELMRACWQWNPSDR-----PSFAEI 374 >2H8H-A nrPDB Length = 535 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 115/271 (42%), Gaps = 22/271 (8%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 WE P ++ + E LG G FG V + T A+K L + E L Sbjct: 262 WEIPRESL----RLEV--KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFL 310 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARFYA 148 E ++++ + LV+L +Y+V EY+ G + L+ P A Sbjct: 311 QEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 369 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----E 204 AQI Y+ ++ ++RDL+ N+L+ + +V DFG A+ ++ +T + Sbjct: 370 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 429 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHF 262 + APE L + D W+ G+L+ E+ G P+ ++ +++ G ++ P Sbjct: 430 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 489 Query: 263 SSDLKDLLRNLLQVDLTKR--FGNLKNGVND 291 L DL+ + + +R F L+ + D Sbjct: 490 PESLHDLMCQCWRKEPEERPTFEYLQAFLED 520 >1JPA-A nrPDB Length = 312 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 125/302 (41%), Gaps = 34/302 (11%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH- 69 E+V+EF + +K + +G G FG V K G Sbjct: 18 DPNEAVREFAKEIDISCVK----------------IEQVIGAGEFGEVCSGHLKLPGKRE 61 Query: 70 --FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGG 127 A+K L KQ L+E I+ + P ++ LE ++ + ++ E++ G Sbjct: 62 IFVAIKTLK--SGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENG 119 Query: 128 EMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF 186 + S LR+ G+F+ I +YL ++ ++RDL N+L++ +V+DF Sbjct: 120 SLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDF 179 Query: 187 GFAKRVKGRTWTLCGT--------PEYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYP 237 G ++ ++ T T + APE I + + A D W+ G++++E M+ G Sbjct: 180 GLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGER 239 Query: 238 PFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKN 294 P++ + I ++ P S L L+ + Q D R FG + N ++ + Sbjct: 240 PYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIR 299 Query: 295 HK 296 + Sbjct: 300 NP 301 >1KOA-A nrPDB Length = 491 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 82/312 (26%), Positives = 130/312 (41%), Gaps = 35/312 (11%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 LD ++ + LGTG+FG V V + TGN+FA K + E E + + + Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTPHESDKETVRKEIQTMSVLR 106 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL-RRIGRFSEPHARFYAAQIVLTFEYLH 159 P LV L +F+D++ + M+ E++ GGE+F + + SE A Y Q+ ++H Sbjct: 107 HPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMH 166 Query: 160 SLDLIYRDLKPENLLID--QQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEIILSKG 215 + ++ DLKPEN++ + +++ DFG + + GT E+ APE+ K Sbjct: 167 ENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKP 226 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLKDLLR 271 D W++GVL Y + +G PF + + + S S S D KD +R Sbjct: 227 VGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIR 286 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331 LL D R ++ H W PG S Sbjct: 287 KLLLADPNTRM-----TIHQALEHPWLT------------------PGNAPGRDSQIPSS 323 Query: 332 EEEEIRVSINEK 343 +IR SI K Sbjct: 324 RYTKIRDSIKTK 335 >6F3F-A nrPDB Length = 455 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 115/271 (42%), Gaps = 22/271 (8%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 WE P ++ + E LG G FG V + T A+K L + E L Sbjct: 182 WEIPRESL----RLEV--KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFL 230 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARFYA 148 E ++++ + LV+L +Y+V EY+ G + L+ P + Sbjct: 231 QEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMS 289 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----E 204 AQI Y+ ++ ++RDL+ N+L+ + +V DFG A+ ++ +T + Sbjct: 290 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 349 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHF 262 + APE L + D W+ G+L+ E+ G P+ ++ +++ G ++ P Sbjct: 350 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 409 Query: 263 SSDLKDLLRNLLQVDLTKR--FGNLKNGVND 291 L DL+ + + +R F L+ + D Sbjct: 410 PESLHDLMCQCWRKEPEERPTFEYLQAFLED 440 >4P5Q-A nrPDB Length = 361 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 58/251 (23%), Positives = 106/251 (42%), Gaps = 14/251 (5%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNH---FAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 K +G G FG V + K A+K L KQ L E I+ Sbjct: 34 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLK--VGYTEKQRRDFLGEASIMGQF 91 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYL 158 + P +++LE + + +V EY+ G + S LR+ +F+ I +YL Sbjct: 92 DHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL 151 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP------EYLAPEIIL 212 + ++RDL N+LI+ +V+DFG ++ ++ T + +PE I Sbjct: 152 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA 211 Query: 213 SKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 + + A D W+ G++++E M+ G P++ + + + G ++ P + L L+ Sbjct: 212 YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLM 271 Query: 271 RNLLQVDLTKR 281 + Q D R Sbjct: 272 LDCWQKDRNNR 282 >6NPU-A nrPDB Length = 298 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 65/261 (24%), Positives = 117/261 (44%), Gaps = 19/261 (7%) Query: 36 QNTAHLDQFERIK-------TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 Q + + D++E + LG G +G V K+ A+K L + + ++E Sbjct: 13 QGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEE 68 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--F 146 L E +++ + P LV+L Y++ E++ G + +LR R + Sbjct: 69 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLY 128 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP--- 203 A QI EYL + I+RDL N L+ + ++V DFG ++ + G T+T Sbjct: 129 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFP 188 Query: 204 -EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPS 260 ++ APE + ++ D WA GVL++E+A G P+ Q+YE + ++ P Sbjct: 189 IKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPE 248 Query: 261 HFSSDLKDLLRNLLQVDLTKR 281 + +L+R Q + + R Sbjct: 249 GCPEKVYELMRACWQWNPSDR 269 >3IS5-A nrPDB Length = 285 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 72/271 (26%), Positives = 127/271 (46%), Gaps = 20/271 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D F + LG+G+FG V LV+ + +G +K ++K + +E E +L++++ Sbjct: 22 DLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVP--MEQIEAEIEVLKSLDH 79 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR----RIGRFSEPHARFYAAQIVLTFEY 157 P ++K+ F+D N+Y+VME GGE+ + R SE + Q++ Y Sbjct: 80 PNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAY 139 Query: 158 LHSLDLIYRDLKPENLLIDQ---QGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIIL 212 HS ++++DLKPEN+L I++ DFG A+ K + GT Y+APE+ Sbjct: 140 FHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFK 199 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF---SSDLKDL 269 + D W+ GV++Y + G PF ++ +K + + + DL Sbjct: 200 -RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAVDL 258 Query: 270 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 L+ +L D +R + +H+WF Sbjct: 259 LKQMLTKDPERR-----PSAAQVLHHEWFKQ 284 >3KN6-A nrPDB Length = 325 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 84/253 (33%), Positives = 129/253 (50%), Gaps = 24/253 (9%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVK 106 K LG GSF HK++ FA+KI+ K + +T E L+ P +VK Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK------RMEANTQKEITALKLCEGHPNIVK 70 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYR 166 L F D + ++VME + GGE+F +++ FSE A + ++V ++H + +++R Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 130 Query: 167 DLKPENLLI---DQQGYIQVTDFGFAKRVKGRT---WTLCGTPEYLAPEIILSKGYNKAV 220 DLKPENLL + I++ DFGFA+ T C T Y APE++ GY+++ Sbjct: 131 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESC 190 Query: 221 DWWALGVLIYEMAAGYPPFF-------ADQPIQIYEKIVSGKVRFP----SHFSSDLKDL 269 D W+LGV++Y M +G PF ++I +KI G F + S + KDL Sbjct: 191 DLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDL 250 Query: 270 LRNLLQVDLTKRF 282 ++ LL VD KR Sbjct: 251 IQGLLTVDPNKRL 263 >2X4F-A nrPDB Length = 373 Score = 247 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 71/262 (27%), Positives = 125/262 (47%), Gaps = 17/262 (6%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + LG G FG+V + TG A KI+ + + K E NE ++ ++ L++L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGM---KDKEEVKNEISVMNQLDHANLIQL 151 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHL-RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYR 166 +F+ +++ +VMEYV GGE+F + +E + QI ++H + +++ Sbjct: 152 YDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHL 211 Query: 167 DLKPENLLIDQQ--GYIQVTDFGFAKRVKGRTWTLC--GTPEYLAPEIILSKGYNKAVDW 222 DLKPEN+L + I++ DFG A+R K R GTPE+LAPE++ + D Sbjct: 212 DLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDM 271 Query: 223 WALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRNLLQVDL 278 W++GV+ Y + +G PF D + I++ + S + K+ + LL + Sbjct: 272 WSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEK 331 Query: 279 TKRFGNLKNGVNDIKNHKWFAT 300 + R ++ H W + Sbjct: 332 SWRI-----SASEALKHPWLSD 348 >1K9A-A nrPDB Length = 450 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 121/266 (45%), Gaps = 14/266 (5%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 ++ + + ++T+G G FG VML ++ GN A+K + + L E ++ Sbjct: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQ 242 Query: 99 VNFPFLVKLEYSF-KDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTF 155 + LV+L ++ LY+V EY+ G + +LR GR ++ + Sbjct: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG 215 EYL + ++RDL N+L+ + +V+DFG K T ++ APE + K Sbjct: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKK 362 Query: 216 YNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNL 273 ++ D W+ G+L++E+ + G P+ + ++ G K+ P + D+++N Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 Query: 274 LQVDLTKR--FGNLKNGVNDIKNHKW 297 +D R F L+ + I+ H+ Sbjct: 423 WHLDAATRPTFLQLREQLEHIRTHEL 448 >4EBW-A nrPDB Length = 304 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 113/272 (41%), Gaps = 15/272 (5%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGN---HFAMKILDKQKVVKLKQIEHTLN 91 ++ E + +G G FG V + N A+K E L Sbjct: 31 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN--CTSDSVREKFLQ 88 Query: 92 EKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQ 150 E ++ + P +VKL +N ++++ME GE+ S L+ R YA Q Sbjct: 89 EALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQ 147 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG----TPEYL 206 + YL S ++RD+ N+L+ +++ DFG ++ ++ T+ +++ Sbjct: 148 LSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 207 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSS 264 APE I + + A D W GV ++E+ G PF + + +I +G ++ P + Sbjct: 208 APESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPP 267 Query: 265 DLKDLLRNLLQVDLTK--RFGNLKNGVNDIKN 294 L L+ D ++ RF LK ++ I Sbjct: 268 TLYSLMTKCWAYDPSRRPRFTELKAQLSTILE 299 >3NIZ-A nrPDB Length = 311 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 124/297 (41%), Gaps = 43/297 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++++++++ +G G++G V K + G A+K + + E +L+ ++ Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDA-EDEGIPSTAIREISLLKELH 77 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLH 159 P +V L L +V E++ ++ L + + Y Q++ + H Sbjct: 78 HPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCH 136 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIILS-KG 215 +++RDLKP+NLLI+ G +++ DFG A+ + R++T T Y AP++++ K Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS-----GKVRFP----------- 259 Y+ +VD W++G + EM G P F KI S +P Sbjct: 197 YSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR 256 Query: 260 --------------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 F + DLL N+L D KR D NH +F D Sbjct: 257 TFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRI-----SARDAMNHPYFKDLD 308 >2Y6O-A nrPDB Length = 291 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 116/266 (43%), Gaps = 16/266 (6%) Query: 45 ERIKTLGTGSFGRVMLVKHKETGNH---FAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + K +G G FG V + K G A+K L KQ L+E I+ + Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLK--AGYTDKQRRDFLSEASIMGQFDH 74 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHS 160 P ++ LE + ++ EY+ G + + LR+ GRF+ I +YL Sbjct: 75 PNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSD 134 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP------EYLAPEIILSK 214 + ++RDL N+L++ +V+DFG ++ ++ T + APE I + Sbjct: 135 MSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYR 194 Query: 215 GYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRN 272 + A D W+ G++++E M+ G P++ + + I G ++ P L L+ + Sbjct: 195 KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLD 254 Query: 273 LLQVDLTKR--FGNLKNGVNDIKNHK 296 Q + + R FG + N ++ + + Sbjct: 255 CWQKERSDRPKFGQIVNMLDKLIRNP 280 >1BYG-A nrPDB Length = 278 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 121/266 (45%), Gaps = 14/266 (5%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 ++ + + ++T+G G FG VML ++ GN A+K + + L E ++ Sbjct: 18 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQ 70 Query: 99 VNFPFLVKLEYSF-KDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTF 155 + LV+L ++ LY+V EY+ G + +LR GR ++ + Sbjct: 71 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 130 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG 215 EYL + ++RDL N+L+ + +V+DFG K T ++ APE + K Sbjct: 131 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKK 190 Query: 216 YNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNL 273 ++ D W+ G+L++E+ + G P+ + ++ G K+ P + ++++N Sbjct: 191 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNC 250 Query: 274 LQVDLTKR--FGNLKNGVNDIKNHKW 297 +D R F L+ + IK H+ Sbjct: 251 WHLDAAMRPSFLQLREQLEHIKTHEL 276 >4WNO-A nrPDB Length = 287 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 81/283 (28%), Positives = 141/283 (49%), Gaps = 24/283 (8%) Query: 32 ENPAQNTAHLDQFERIKT--LGTGSFGRVMLVKHKETGN-HFAMKILDKQKVVKLKQIEH 88 E T + +FE + +G G+F V +H+ + A+K ++K+ + K + + Sbjct: 6 EPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL-- 63 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148 E +IL+ + +V L + +++Y+VMEY GG++ +L + SE R + Sbjct: 64 LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFL 123 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQG---------YIQVTDFGFAKRVKGRTW-- 197 QI LHS +I+RDLKP+N+L+ +++ DFGFA+ ++ Sbjct: 124 QQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAA 183 Query: 198 TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI---YEKIVSG 254 TLCG+P Y+APE+I+S+ Y+ D W++G ++Y+ G PF A P + YEK + Sbjct: 184 TLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTL 243 Query: 255 KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 P S+ L+ LL LLQ + R ++ +H + Sbjct: 244 VPTIPRETSAPLRQLLLALLQRNHKDRMD-----FDEFFHHPF 281 >3V5Q-A nrPDB Length = 297 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 59/268 (22%), Positives = 103/268 (38%), Gaps = 31/268 (11%) Query: 43 QFERIKTLGTGSFGRVMLVKH-----KETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 + LG G+FG+V L + + A+K L + K E +L Sbjct: 16 DIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD---FQREAELLT 72 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR----------------FSE 141 + +VK D L MV EY+ G++ LR G Sbjct: 73 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 142 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG 201 A+QI YL S ++RDL N L+ +++ DFG ++ V + G Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVG 192 Query: 202 -----TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGK 255 ++ PE I+ + + D W+ GV+++E+ G P+F ++ E I G+ Sbjct: 193 GHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGR 252 Query: 256 -VRFPSHFSSDLKDLLRNLLQVDLTKRF 282 + P ++ D++ Q + +R Sbjct: 253 VLERPRVCPKEVYDVMLGCWQREPQQRL 280 >4MYG-A nrPDB Length = 372 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 137/321 (42%), Gaps = 24/321 (7%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 +G+G++G V K +G A+K L + + E +L+ + ++ L Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHENVIGLLD 109 Query: 110 SFKDNSNL------YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 F S+L Y+VM ++ ++ + FSE ++ Q++ +Y+HS + Sbjct: 110 VFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGV 166 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KGYNKAVDW 222 ++RDLKP NL +++ +++ DFG A+ T Y APE+ILS YN+ VD Sbjct: 167 VHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDI 226 Query: 223 WALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF-----SSDLKDLLRNLLQ-- 275 W++G ++ EM G F + +I+ + F K +++L Q Sbjct: 227 WSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP 286 Query: 276 -VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN----FDD 330 D T+ F D+ D + + PF F+ P + + FDD Sbjct: 287 RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDD 346 Query: 331 YEEEEIRVSINEKCGKEFSEF 351 E E +++++E + E Sbjct: 347 SLEHE-KLTVDEWKQHIYKEI 366 >3DAK-A nrPDB Length = 290 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 63/291 (21%), Positives = 120/291 (41%), Gaps = 38/291 (13%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 + + D +E + +G+G+ V A+K ++ +K ++ L E + + Sbjct: 6 SINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTS--MDELLKEIQAMS 63 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL--------RRIGRFSEPHARFYAA 149 + P +V SF L++VM+ + GG + + + G E Sbjct: 64 QCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILR 123 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--------KGRTWTLCG 201 +++ EYLH I+RD+K N+L+ + G +Q+ DFG + + T G Sbjct: 124 EVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVG 183 Query: 202 TPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS 260 TP ++APE++ +GY+ D W+ G+ E+A G P+ P+++ + PS Sbjct: 184 TPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQN--DPPS 241 Query: 261 ------------HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 + + ++ LQ D KR ++ HK+F Sbjct: 242 LETGVQDKEMLKKYGKSFRKMISLCLQKDPEKR-----PTAAELLRHKFFQ 287 >6GU6-A nrPDB Length = 302 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 74/302 (24%), Positives = 128/302 (42%), Gaps = 43/302 (14%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 ++ + +I+ +G G++G V +HK TG AMK + + + + E +L Sbjct: 2 PLGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLL 60 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR---FSEPHARFYAAQIVL 153 + + P +V L+ +S LY++ E++ ++ +L I + Y QI+ Sbjct: 61 KELRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 119 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEI 210 + HS +++RDLKP+NLLID +G I++ DFG A+ + R +T T Y +PE+ Sbjct: 120 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 179 Query: 211 ILSK-GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK-- 267 +L Y+ VD W++G + E+A P F D I +I + +++ Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 239 Query: 268 ---------------------------DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 DLL +L D KR NH +F Sbjct: 240 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM-----ALNHPYFND 294 Query: 301 TD 302 D Sbjct: 295 LD 296 >3PPZ-A nrPDB Length = 309 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 123/268 (45%), Gaps = 16/268 (5%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 + +G GSFG V + G+ A+KIL ++ +++ L E I++ + P Sbjct: 38 DLNIKEKIGAGSFGTVHRAEW--HGSDVAVKIL-MEQDFHAERVNEFLREVAIMKRLRHP 94 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG---RFSEPHARFYAAQIVLTFEYLH 159 +V + NL +V EY+ G ++ L + G + E A + YLH Sbjct: 95 NIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLH 154 Query: 160 SLD--LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---TWTLCGTPEYLAPEIILSK 214 + + +++RDLK NLL+D++ ++V DFG ++ + + GTPE++APE++ + Sbjct: 155 NRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDE 214 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI--VSGKVRFPSHFSSDLKDLLRN 272 N+ D ++ GV+++E+A P+ P Q+ + ++ P + + + ++ Sbjct: 215 PSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEG 274 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 + KR + D+ + Sbjct: 275 CWTNEPWKRPSFA--TIMDLLR-PLIKS 299 >3DKO-A nrPDB Length = 318 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 116/267 (43%), Gaps = 16/267 (5%) Query: 31 WENPAQNTAHLDQ------FERIKTLGTGSFGRVMLVKHKETGNH-FAMKILDKQKVVKL 83 +E+P + + + + +G G FG V + K G A+ I + Sbjct: 26 YEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTE 85 Query: 84 KQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEP 142 KQ L E I+ + P +V LE + +V+E++ G + + LR+ G+F+ Sbjct: 86 KQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVI 145 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---TWTL 199 I YL + ++RDL N+L++ +V+DFG ++ ++ +T Sbjct: 146 QLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTT 205 Query: 200 CGTP---EYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG- 254 G + APE I + + A D W+ G++++E M+ G P++ + + I G Sbjct: 206 TGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGY 265 Query: 255 KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 ++ P + L L+ + Q + +R Sbjct: 266 RLPAPMDCPAGLHQLMLDCWQKERAER 292 >3TT0-A nrPDB Length = 382 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 134/316 (42%), Gaps = 43/316 (13%) Query: 11 SEQESVKEFLAKAKEDFLK---KWENPAQNTAHLDQFERIKTLGTGSFGRVMLV------ 61 +E + LA E L +WE P D+ K LG G+FG+V+L Sbjct: 41 TENLYFQGMLAGVSEYELPEDPRWELPR------DRLVLGKPLGEGAFGQVVLAEAIGLD 94 Query: 62 KHKETG-NHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYM 119 K K A+K+L K + ++E +++ + ++ L + + LY+ Sbjct: 95 KDKPNRVTKVAVKMLKSDA--TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYV 152 Query: 120 VMEYVPGGEMFSHLRRIGR----------------FSEPHARFYAAQIVLTFEYLHSLDL 163 ++EY G + +L+ S A Q+ EYL S Sbjct: 153 IVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKC 212 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGT-----PEYLAPEIILSKGYNK 218 I+RDL N+L+ + +++ DFG A+ + + T +++APE + + Y Sbjct: 213 IHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTH 272 Query: 219 AVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQV 276 D W+ GVL++E+ G P+ ++++ + G ++ PS+ +++L ++R+ Sbjct: 273 QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHA 332 Query: 277 DLTKRFGNLKNGVNDI 292 ++R K V D+ Sbjct: 333 VPSQR-PTFKQLVEDL 347 >5SYS-A nrPDB Length = 286 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 114/271 (42%), Gaps = 22/271 (8%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 WE P ++ + E LG G FG + T A+K L + E L Sbjct: 13 WEIPRESL----RLEV--KLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSP----EAFL 61 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR--IGRFSEPHARFYA 148 E ++++ + LV+L +Y+V EY+ G + L+ P A Sbjct: 62 QEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 120 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----E 204 AQI Y+ ++ ++RDL+ N+L+ + +V DFG A+ ++ +T + Sbjct: 121 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 180 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHF 262 + APE L + D W+ G+L+ E+ G P+ ++ +++ G ++ P Sbjct: 181 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 240 Query: 263 SSDLKDLLRNLLQVDLTKR--FGNLKNGVND 291 L DL+ + D +R F L+ + D Sbjct: 241 PESLHDLMCQCWRKDPEERPTFEYLQAFLED 271 >2VWV-A nrPDB Length = 302 Score = 243 bits (621), Expect = 9e-65, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 116/285 (40%), Gaps = 32/285 (11%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH- 69 E+V+EF + ++K + +G G FG V + K G Sbjct: 1 DPNEAVREFAKEIDVSYVK----------------IEEVIGAGEFGEVCRGRLKAPGKKE 44 Query: 70 --FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGG 127 A+K L +Q L+E I+ P +++LE ++ + ++ E++ G Sbjct: 45 SCVAIKTLKGG--YTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENG 102 Query: 128 EMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF 186 + S LR G+F+ I YL + ++RDL N+L++ +V+DF Sbjct: 103 ALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDF 162 Query: 187 GFAKRVKGRTWTLCGT--------PEYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYP 237 G ++ ++ + T + APE I + + A D W+ G++++E M+ G Sbjct: 163 GLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGER 222 Query: 238 PFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 P++ + I ++ P + L L+ + Q D R Sbjct: 223 PYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNAR 267 >5L6P-A nrPDB Length = 298 Score = 243 bits (621), Expect = 9e-65, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 122/303 (40%), Gaps = 34/303 (11%) Query: 10 GSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH 69 E+V+EF + +K + +G G FG V + K+ G Sbjct: 3 SDPNEAVREFAKEIDVSCVK----------------IEEVIGAGEFGEVCRGRLKQPGRR 46 Query: 70 ---FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPG 126 A+K L +Q L+E I+ + P +++LE + + ++ E++ Sbjct: 47 EVFVAIKTLK--VGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMEN 104 Query: 127 GEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTD 185 + S LR G+F+ I +YL ++ ++RDL N+L++ +V+D Sbjct: 105 CALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSD 164 Query: 186 FGFAKRVKGRTWTLCGT--------PEYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGY 236 FG ++ ++ T + APE I + + A D W+ G++++E M+ G Sbjct: 165 FGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGE 224 Query: 237 PPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIK 293 P++ + + ++ P + L L+ + D R F + N ++ + Sbjct: 225 RPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLI 284 Query: 294 NHK 296 + Sbjct: 285 RNP 287 >6GQK-A nrPDB Length = 328 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 127/307 (41%), Gaps = 39/307 (12%) Query: 18 EFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV-----KHKETGNHFAM 72 ++ + + KWE P ++ KTLG G+FG+V+ + A+ Sbjct: 23 SYIDPTQLPYDHKWEFPR------NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAV 76 Query: 73 KILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 K+L + E ++E ++L + N +V L + ++ EY G++ + Sbjct: 77 KMLKPSA--HSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLN 134 Query: 132 HLRRI----------------GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI 175 LRR + H ++ Q+ +L S + I+RDL N+L+ Sbjct: 135 FLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILL 194 Query: 176 DQQGYIQVTDFGFAKRVK-GRTWTLCGTPE----YLAPEIILSKGYNKAVDWWALGVLIY 230 ++ DFG A+ +K + G ++APE I + Y D W+ G+ ++ Sbjct: 195 THGNITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLW 254 Query: 231 EMAA-GYPPFFADQ-PIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKN 287 E+ + G P+ + Y+ I G ++ P + +++ D+++ D KR K Sbjct: 255 ELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKR-PTFKQ 313 Query: 288 GVNDIKN 294 V DI+ Sbjct: 314 IVQDIEK 320 >2DQ7-X nrPDB Length = 283 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 117/271 (43%), Gaps = 22/271 (8%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 WE P ++ + IK LG G FG V + A+K L + E L Sbjct: 4 WEIPRES------LQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSP----ESFL 52 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARFYA 148 E +I++ + LV+L +Y+V EY+ G + L+ P+ A Sbjct: 53 EEAQIMKKLKHDKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMA 111 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----E 204 AQ+ Y+ ++ I+RDL+ N+L+ ++ DFG A+ ++ +T + Sbjct: 112 AQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIK 171 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHF 262 + APE L + D W+ G+L+ E+ G P+ ++ E++ G ++ P Sbjct: 172 WTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDC 231 Query: 263 SSDLKDLLRNLLQVDLTKR--FGNLKNGVND 291 L +L+ + + D +R F L++ + D Sbjct: 232 PISLHELMIHCWKKDPEERPTFEYLQSFLED 262 >4AT3-A nrPDB Length = 299 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 58/261 (22%), Positives = 104/261 (39%), Gaps = 28/261 (10%) Query: 46 RIKTLGTGSFGRVMLVKHKE-----TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 + LG G+FG+V L + A+K L K E +L + Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD---FHREAELLTNLQ 73 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-------------FSEPHARFY 147 +VK + L MV EY+ G++ LR G ++ Sbjct: 74 HEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHI 133 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG-----T 202 A QI YL S ++RDL N L+ + +++ DFG ++ V + G Sbjct: 134 AQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 193 Query: 203 PEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGK-VRFPS 260 ++ PE I+ + + D W+LGV+++E+ G P++ ++ E I G+ ++ P Sbjct: 194 IRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPR 253 Query: 261 HFSSDLKDLLRNLLQVDLTKR 281 ++ +L+ Q + R Sbjct: 254 TCPQEVYELMLGCWQREPHMR 274 >2HW6-A nrPDB Length = 307 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 134/305 (43%), Gaps = 47/305 (15%) Query: 35 AQNTAHLDQFERI-KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK 93 + D ++ + LG G++ +V + G +A+KI++KQ ++ E Sbjct: 5 SLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRV---FREV 61 Query: 94 RILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 L +++L F+D++ Y+V E + GG + +H+++ F+E A + Sbjct: 62 ETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVA 121 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVK----------GRTWTL 199 ++LH+ + +RDLKPEN+L + +++ DF +K T Sbjct: 122 AALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTP 181 Query: 200 CGTPEYLAPEII-----LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ-------- 246 CG+ EY+APE++ + Y+K D W+LGV++Y M +GYPPF Sbjct: 182 CGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEV 241 Query: 247 -------IYEKIVSGKVRFPS----HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNH 295 ++E I GK FP H SS+ KDL+ LL D +R + H Sbjct: 242 CRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL-----SAAQVLQH 296 Query: 296 KWFAT 300 W Sbjct: 297 PWVQG 301 >1NY3-A nrPDB Length = 400 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 93/315 (29%), Positives = 157/315 (49%), Gaps = 40/315 (12%) Query: 41 LDQFERI-KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL-QA 98 +D ++ + LG G G+V+ + +K T FA+K+L + E + +A Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 111 Query: 99 VNFPFLVKLEYSFKD----NSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIV 152 P +V++ +++ L +VME + GGE+FS ++ G F+E A I Sbjct: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQ---QGYIQVTDFGFAKRVKGRT--WTLCGTPEYLA 207 +YLHS+++ +RD+KPENLL +++TDFGFAK T C TP Y+A Sbjct: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI----YEKIVSGKVRFP---- 259 PE++ + Y+K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP Sbjct: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 Query: 260 SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKF 319 S S ++K L+RNLL+ + T+R + + NH W + + + P Sbjct: 292 SEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQSTKVP------QTPLHTSR 340 Query: 320 KGPGDTSNFDDYEEE 334 D ++D +EE Sbjct: 341 VLKEDKERWEDVKEE 355 >1KOB-A nrPDB Length = 387 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 76/312 (24%), Positives = 135/312 (43%), Gaps = 36/312 (11%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 D ++ ++ LG+G+FG V K TG F K ++ + ++ NE I+ ++ Sbjct: 50 YDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK---NEISIMNQLH 106 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLH 159 P L+ L +F+D + +++E++ GGE+F + + SE Y Q +++H Sbjct: 107 HPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMH 166 Query: 160 SLDLIYRDLKPENLLIDQQ--GYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSKG 215 +++ D+KPEN++ + + +++ DFG A ++ T E+ APEI+ + Sbjct: 167 EHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREP 226 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLR 271 D WA+GVL Y + +G PF + ++ + + F S + KD ++ Sbjct: 227 VGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIK 286 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331 NLLQ + KR V+D H W TS Sbjct: 287 NLLQKEPRKRL-----TVHDALEHPWLKGDH-------------------SNLTSRIPSS 322 Query: 332 EEEEIRVSINEK 343 +IR I EK Sbjct: 323 RYNKIRQKIKEK 334 >5A46-A nrPDB Length = 386 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 126/295 (42%), Gaps = 40/295 (13%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV------KHKETG-NHFAMKILDKQKVV 81 +WE P D+ K LG G FG+V+L K K A+K+L Sbjct: 33 PRWELPR------DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA-- 84 Query: 82 KLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-- 138 K + ++E +++ + ++ L + + LY+++EY G + +L+ Sbjct: 85 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 144 Query: 139 --------------FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184 S A Q+ EYL S I+RDL N+L+ + +++ Sbjct: 145 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 204 Query: 185 DFGFAKRVKGRTWTLCGT-----PEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPP 238 DFG A+ + + T +++APE + + Y D W+ GVL++E+ G P Sbjct: 205 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 264 Query: 239 FFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 + ++++ + G ++ PS+ +++L ++R+ ++R K V D+ Sbjct: 265 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR-PTFKQLVEDL 318 >2R2P-A nrPDB Length = 295 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 61/283 (21%), Positives = 116/283 (40%), Gaps = 25/283 (8%) Query: 31 WENPAQNTAHLDQ------FERIKTLGTGSFGRVMLVKHKETGNH---FAMKILDKQKVV 81 +E+P Q + + +G G FG V + K G A+K L Sbjct: 5 YEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLK--VGY 62 Query: 82 KLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFS 140 KQ L E I+ + P ++ LE + + +V EY+ G + + L++ G+F+ Sbjct: 63 TEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFT 122 Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC 200 I +YL + ++RDL N+LI+ +V+DFG ++ ++ Sbjct: 123 VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 182 Query: 201 GTP------EYLAPEIILSKGYNKAVDWWALGVLIYEMA-AGYPPFFADQPIQIYEKIVS 253 T + APE I + + A D W+ G++++E+ G P++ + + + Sbjct: 183 TTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEE 242 Query: 254 G-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNH 295 G ++ P + L L+ + Q + R ++I N Sbjct: 243 GYRLPSPMDCPAALYQLMLDCWQKERNSR-----PKFDEIVNM 280 >2J0K-A nrPDB Length = 656 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 113/272 (41%), Gaps = 15/272 (5%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGN---HFAMKILDKQKVVKLKQIEHTLN 91 ++ E + +G G FG V + N A+K E L Sbjct: 383 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKN--CTSDSVREKFLQ 440 Query: 92 EKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQ 150 E ++ + P +VKL +N ++++ME GE+ S L+ R YA Q Sbjct: 441 EALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQ 499 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG----TPEYL 206 + YL S ++RD+ N+L+ +++ DFG ++ ++ T+ +++ Sbjct: 500 LSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 559 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSS 264 APE I + + A D W GV ++E+ G PF + + +I +G ++ P + Sbjct: 560 APESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPP 619 Query: 265 DLKDLLRNLLQVDLTK--RFGNLKNGVNDIKN 294 L L+ D ++ RF LK ++ I Sbjct: 620 TLYSLMTKCWAYDPSRRPRFTELKAQLSTILE 651 >4E93-A nrPDB Length = 377 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 61/263 (23%), Positives = 107/263 (40%), Gaps = 12/263 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + + +G G+FG V + + A+K + LK L E RIL+ + Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLK--AKFLQEARILKQYSH 171 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 160 P +V+L +Y+VME V GG+ + LR G R EYL S Sbjct: 172 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 231 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE-----YLAPEIILSKG 215 I+RDL N L+ ++ ++++DFG ++ + G + APE + Sbjct: 232 KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR 291 Query: 216 YNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVS-GKVRFPSHFSSDLKDLLRNL 273 Y+ D W+ G+L++E + G P+ Q E + G++ P + L+ Sbjct: 292 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 351 Query: 274 LQVDLTKR--FGNLKNGVNDIKN 294 + +R F + + I+ Sbjct: 352 WAYEPGQRPSFSTIYQELQSIRK 374 >2OZA-A nrPDB Length = 356 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 93/315 (29%), Positives = 157/315 (49%), Gaps = 40/315 (12%) Query: 41 LDQFERI-KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL-QA 98 +D ++ + LG G G+V+ + +K T FA+K+L + E + +A Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 67 Query: 99 VNFPFLVKLEYSFKD----NSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIV 152 P +V++ +++ L +VME + GGE+FS ++ G F+E A I Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQ---QGYIQVTDFGFAKRVKGRT--WTLCGTPEYLA 207 +YLHS+++ +RD+KPENLL +++TDFGFAK T C TP Y+A Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 187 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI----YEKIVSGKVRFP---- 259 PE++ + Y+K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP Sbjct: 188 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 247 Query: 260 SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKF 319 S S ++K L+RNLL+ + T+R + + NH W + + + P Sbjct: 248 SEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQSTKVP------QTPLHTSR 296 Query: 320 KGPGDTSNFDDYEEE 334 D ++D +EE Sbjct: 297 VLKEDKERWEDVKEE 311 >3A4O-X nrPDB Length = 286 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 120/273 (43%), Gaps = 23/273 (8%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 WE P ++ + +K LG G FG V + + + A+K L + ++ L Sbjct: 8 WEIPRESI------KLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMS----VQAFL 56 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARFYA 148 E +++ + LV+L +Y++ EY+ G + L+ G+ P ++ Sbjct: 57 EEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFS 116 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----E 204 AQI Y+ + I+RDL+ N+L+ + ++ DFG A+ ++ +T + Sbjct: 117 AQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIK 176 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGKVRFP--SH 261 + APE I + D W+ G+L+YE+ G P+ + + G R P + Sbjct: 177 WTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQG-YRMPRVEN 235 Query: 262 FSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDI 292 +L D+++ + +R F L++ ++D Sbjct: 236 CPDELYDIMKMCWKEKAEERPTFDYLQSVLDDF 268 >3GQL-A nrPDB Length = 326 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 127/295 (43%), Gaps = 40/295 (13%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV------KHKETG-NHFAMKILDKQKVV 81 +WE P D+ K LG G+FG+V+L K K A+K+L Sbjct: 21 PRWELPR------DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA-- 72 Query: 82 KLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-- 138 K + ++E +++ + ++ L + + LY+++EY G + +L+ Sbjct: 73 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 132 Query: 139 --------------FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184 S A Q+ EYL S I+RDL N+L+ + +++ Sbjct: 133 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 192 Query: 185 DFGFAKRVKGRTWTLCGT-----PEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPP 238 DFG A+ + + T +++APE + + Y D W+ GVL++E+ G P Sbjct: 193 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 252 Query: 239 FFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 + ++++ + G ++ PS+ +++L ++R+ ++R K V D+ Sbjct: 253 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR-PTFKQLVEDL 306 >4UY9-A nrPDB Length = 323 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 69/274 (25%), Positives = 115/274 (41%), Gaps = 20/274 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ-IEHTLNEKRILQAVNF 101 + + +G G FG+V G+ A+K + Q IE+ E ++ + Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++ L NL +VME+ GG + L R +A QI YLH Sbjct: 68 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYLHDE 126 Query: 162 DL---IYRDLKPENLLID--------QQGYIQVTDFGFAKRVKGRT-WTLCGTPEYLAPE 209 + I+RDLK N+LI +++TDFG A+ T + GT ++APE Sbjct: 127 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPE 186 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPSHFSSDLK 267 +I + ++K D W+ GVL++E+ G PF + + + K + PS Sbjct: 187 VIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFA 246 Query: 268 DLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFA 299 L+ + D R F N+ + + I+ +F Sbjct: 247 KLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFE 280 >3ZDU-A nrPDB Length = 325 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 85/315 (26%), Positives = 142/315 (45%), Gaps = 42/315 (13%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++ +E + +G GS+G VM KHK TG A+KI ++ + +I + E + L+ + Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKI--AMREIKFLKQFH 59 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 LV L F+ +++V E++ + R Y QI+ +YLHS Sbjct: 60 HENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHS 119 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTW-TLCGTPEYLAPE-IILSKGY 216 ++I+RD+KPEN+L+ Q G ++ DFGFA+ + G + T Y APE ++ Y Sbjct: 120 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSY 179 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH----FSSD------- 265 K VD WALG +I EMA G P + + + KIV H FS Sbjct: 180 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 239 Query: 266 --------------------LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIA 305 L D++ LQ+D R + +D+ +H++F +I Sbjct: 240 LPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISS-----SDLLHHEYFTRDGFIE 294 Query: 306 IYQRKVEAPFIPKFK 320 + +++A + + K Sbjct: 295 KFMPELKAKLLQEAK 309 >4AGU-A nrPDB Length = 311 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 131/310 (42%), Gaps = 43/310 (13%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++++E+I +G GS+G V ++++TG A+K + + + + + L E R+L+ + Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIK-KIALREIRMLKQLK 60 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 P LV L F+ L++V EY + R E + Q + + H Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHK 120 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIILS-KGY 216 + I+RD+KPEN+LI + I++ DFGFA+ + G + T Y +PE+++ Y Sbjct: 121 HNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQY 180 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---------------------- 254 VD WA+G + E+ +G P + + I Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 255 ----------KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI 304 +++FP + S LL+ L +D T+R + +H +F I Sbjct: 241 IPDPEDMEPLELKFP-NISYPALGLLKGCLHMDPTERLTC-----EQLLHHPYFENIREI 294 Query: 305 AIYQRKVEAP 314 ++ + P Sbjct: 295 EDLAKEHDKP 304 >3FXW-A nrPDB Length = 336 Score = 240 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 92/312 (29%), Positives = 156/312 (50%), Gaps = 37/312 (11%) Query: 42 DQFER-IKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 D ++ + LG G G+V+ H+ TG A+K+L ++++H QA Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLY-DSPKARQEVDHHW------QASG 80 Query: 101 FPFLVKLEYSFKDNSN----LYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLT 154 P +V + +++ + L ++ME + GGE+FS ++ G F+E A I Sbjct: 81 GPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTA 140 Query: 155 FEYLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAKRV-KGRTWTLCGTPEYLAPEI 210 ++LHS ++ +RD+KPENLL ++ +++TDFGFAK + T C TP Y+APE+ Sbjct: 141 IQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEV 200 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI----YEKIVSGKVRFP----SHF 262 + + Y+K+ D W+LGV++Y + G+PPF+++ I +I G+ FP S Sbjct: 201 LGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEV 260 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP 322 S D K L+R LL+ D T+R + NH W + + + P Sbjct: 261 SEDAKQLIRLLLKTDPTERL-----TITQFMNHPWINQSMVVP------QTPLHTARVLQ 309 Query: 323 GDTSNFDDYEEE 334 D ++D+ +EE Sbjct: 310 EDKDHWDEVKEE 321 >3KA0-A nrPDB Length = 320 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 92/315 (29%), Positives = 156/315 (49%), Gaps = 40/315 (12%) Query: 41 LDQFERI-KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL-QA 98 +D ++ + LG G G+V+ + +K T FA+K+L + E + +A Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 65 Query: 99 VNFPFLVKLEYSFKD----NSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIV 152 P +V++ +++ L +VME + GGE+FS ++ G F+E A I Sbjct: 66 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 125 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQ---QGYIQVTDFGFAKRVKGRT--WTLCGTPEYLA 207 +YLHS+++ +RD+KPENLL +++TDFGFAK C TP Y+A Sbjct: 126 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVA 185 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI----YEKIVSGKVRFP---- 259 PE++ + Y+K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP Sbjct: 186 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 245 Query: 260 SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKF 319 S S ++K L+RNLL+ + T+R + + NH W + + + P Sbjct: 246 SEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQSTKVP------QTPLHTSR 294 Query: 320 KGPGDTSNFDDYEEE 334 D ++D +EE Sbjct: 295 VLKEDKERWEDVKEE 309 >2PSQ-A nrPDB Length = 370 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 125/295 (42%), Gaps = 40/295 (13%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV----KHKETGNH---FAMKILDKQKVV 81 KWE P D+ K LG G FG+V++ K+ A+K+L Sbjct: 74 PKWEFPR------DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA-- 125 Query: 82 KLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-- 138 K + ++E +++ + ++ L + + LY+++EY G + +LR Sbjct: 126 TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPG 185 Query: 139 --------------FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184 + Q+ EYL S I+RDL N+L+ + +++ Sbjct: 186 MEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIA 245 Query: 185 DFGFAKRVKGRTWTLCGT-----PEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPP 238 DFG A+ + + T +++APE + + Y D W+ GVL++E+ G P Sbjct: 246 DFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSP 305 Query: 239 FFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 + ++++ + G ++ P++ +++L ++R+ ++R K V D+ Sbjct: 306 YPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR-PTFKQLVEDL 359 >5D7A-A nrPDB Length = 308 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 62/276 (22%), Positives = 121/276 (43%), Gaps = 28/276 (10%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFP 102 FE ++ +G G++G+V +H +TG A+K++D V + E E +L+ + Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTGDEEEEIKQEINMLKKYSHHR 74 Query: 103 FLVKLEYSFKDNSN------LYMVMEYVPGGEMFSHLR--RIGRFSEPHARFYAAQIVLT 154 + +F + L++VME+ G + ++ + E + +I+ Sbjct: 75 NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 134 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEII 211 +LH +I+RD+K +N+L+ + +++ DFG + ++ GR T GTP ++APE+I Sbjct: 135 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 194 Query: 212 L-----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSHFSS 264 Y+ D W+LG+ EMA G PP P++ I +S Sbjct: 195 ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSK 254 Query: 265 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 + + + L + ++R + H + Sbjct: 255 KFQSFIESCLVKNHSQR-----PATEQLMKHPFIRD 285 >4XLV-A nrPDB Length = 328 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 63/312 (20%), Positives = 125/312 (40%), Gaps = 27/312 (8%) Query: 23 AKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML--VKHKETGN---HFAMKILDK 77 A + F P + ++ ++ LG GSFG V + G A+K +++ Sbjct: 20 ASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNE 79 Query: 78 QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG 137 L++ LNE +++ +V+L +VME + G++ S+LR + Sbjct: 80 SA--SLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLR 137 Query: 138 RFSE----------PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFG 187 +E AA+I YL++ ++RDL N ++ +++ DFG Sbjct: 138 PEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFG 197 Query: 188 FAKRVKGRTWTLCG-----TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFA 241 + + + G ++APE + + + D W+ GV+++E+ + P+ Sbjct: 198 MTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG 257 Query: 242 DQPIQIYEKIVSGKV-RFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWF 298 Q+ + ++ G P + + DL+R Q + R F + N + D H F Sbjct: 258 LSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDL-HPSF 316 Query: 299 ATTDWIAIYQRK 310 + + K Sbjct: 317 PEVSFFHSEENK 328 >6CCF-A nrPDB Length = 290 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 89/295 (30%), Positives = 139/295 (47%), Gaps = 39/295 (13%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK-------------------- 77 + L+Q++ +G G++G V L ++ H+AMK+L K Sbjct: 1 SMQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQA 60 Query: 78 ---QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKD--NSNLYMVMEYVPGGEMFSH 132 +L +E E IL+ ++ +VKL D NLY+V + + G + Sbjct: 61 AQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME- 119 Query: 133 LRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV 192 + FSE AR Y ++L EYLH +++RD+KP NLL+ G++++ DFG + + Sbjct: 120 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 193 KGRT---WTLCGTPEYLAPEIILSKGYN---KAVDWWALGVLIYEMAAGYPPFFADQPIQ 246 +G + GTP ++APE I G + KA+D WA GV +Y G PF D + Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 239 Query: 247 IYEKIVSGKVRFP--SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 ++ KI + V FP S +LKDL+ +L + R G V DIK H W Sbjct: 240 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIG-----VPDIKLHPWVT 289 >5KMM-A nrPDB Length = 329 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 54/260 (20%), Positives = 101/260 (38%), Gaps = 30/260 (11%) Query: 49 TLGTGSFGRVMLVKHKE-----TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 LG G+FG+V L + A+K L + + E +L + Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE---ASESARQDFQREAELLTMLQHQH 98 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR---------------FSEPHARFYA 148 +V+ + L MV EY+ G++ LR G A Sbjct: 99 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVA 158 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----- 203 +Q+ YL L ++RDL N L+ Q +++ DFG ++ + + G Sbjct: 159 SQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPI 218 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGK-VRFPSH 261 ++ PE IL + + D W+ GV+++E+ G P++ + + I G+ + P Sbjct: 219 RWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA 278 Query: 262 FSSDLKDLLRNLLQVDLTKR 281 ++ ++R Q + +R Sbjct: 279 CPPEVYAIMRGCWQREPQQR 298 >5AMN-A nrPDB Length = 299 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 124/275 (45%), Gaps = 30/275 (10%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV-----KHKETGNHFAMKILDKQKVVKL 83 KWE P +N KTLG G FG+V+ K + A+K+L + Sbjct: 16 PKWEFPRKNLV------LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SP 67 Query: 84 KQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR----- 138 ++ L+E +L+ VN P ++KL + + L +++EY G + LR + Sbjct: 68 SELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGY 127 Query: 139 -----FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK 193 + +A QI +YL + L++RDL N+L+ + ++++DFG ++ V Sbjct: 128 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 187 Query: 194 GRTWTLCGT-----PEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQI 247 + + +++A E + Y D W+ GVL++E+ G P+ P ++ Sbjct: 188 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 247 Query: 248 YEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + + +G ++ P + S ++ L+ + + KR Sbjct: 248 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 282 >6CQF-A nrPDB Length = 297 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 65/271 (23%), Positives = 123/271 (45%), Gaps = 14/271 (5%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 N D ++ ++ LG G++G V + K +G+ A+K++ + + ++ E IL Sbjct: 11 NRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK---EILIL 67 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + +V S+ L++ ME+ G + + G SE + +++ Sbjct: 68 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 127 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPE---I 210 YLHS I+RD+K N+LI+ G +++ DFG + ++ R GTP ++APE + Sbjct: 128 YLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAV 187 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS-----HFSSD 265 L GYN+ D W+LG+ E+A PP F P+++ + + P +S+ Sbjct: 188 ALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAA 247 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHK 296 + ++ L KR K + + + Sbjct: 248 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQP 278 >3QUP-A nrPDB Length = 323 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 125/310 (40%), Gaps = 28/310 (9%) Query: 22 KAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETG---NHFAMKILDKQ 78 ++ +K E+ QF + LG G FG V + K+ A+K+L K Sbjct: 6 GISDELKEKLEDVLIPEQ---QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKML-KA 61 Query: 79 KVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF---KDNSNL---YMVMEYVPGGEMFSH 132 ++ IE L E ++ + P + KL + L +++ ++ G++ + Sbjct: 62 DIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAF 121 Query: 133 LRRIG------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF 186 L + I EYL S + I+RDL N ++ + + V DF Sbjct: 122 LLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADF 181 Query: 187 GFAKRVKGRTWTLCGTP-----EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFF 240 G ++++ + G ++LA E + Y D WA GV ++E+ G P+ Sbjct: 182 GLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYA 241 Query: 241 ADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKW 297 + +IY ++ G +++ P ++ DL+ D +R F L+ + +I H Sbjct: 242 GIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLS 301 Query: 298 FATTDWIAIY 307 +T +Y Sbjct: 302 VLSTSQDPLY 311 >6QAU-A nrPDB Length = 280 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 81/273 (29%), Positives = 136/273 (49%), Gaps = 22/273 (8%) Query: 43 QFERIKTLGTGSFGRVMLVKHK-ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++ + +G G+F V +H+ +T A+K ++K+ + K + + E +IL+ + Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKELQH 69 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 +V L + +++++VMEY GG++ +L+ G SE R + QI LHS Sbjct: 70 ENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSK 129 Query: 162 DLIYRDLKPENLLIDQQG---------YIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEI 210 +I+RDLKP+N+L+ I++ DFGFA+ + LCG+P Y+APE+ Sbjct: 130 GIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEV 189 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI---YEKIVSGKVRFPSHFSSDLK 267 I+S+ Y+ D W++G +IY+ G PPF A+ P + YEK S P S L Sbjct: 190 IMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLA 249 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 +LL LLQ + R +H + Sbjct: 250 NLLLGLLQRNQKDRMD-----FEAFFSHPFLEQ 277 >4AN9-A nrPDB Length = 301 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 68/265 (25%), Positives = 126/265 (47%), Gaps = 11/265 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D FE+I LG G+ G V V HK +G A K++ + +K + E ++L N Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNS 66 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL-HS 160 P++V +F + + + ME++ GG + L++ GR E + ++ YL Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 126 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT-WTLCGTPEYLAPEIILSKGYNKA 219 +++RD+KP N+L++ +G I++ DFG + ++ GT Y++PE + Y+ Sbjct: 127 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHYSVQ 186 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV-SGKVRFPS-HFSSDLKDLLRNLLQVD 277 D W++G+ + EMA G P ++ + IV + PS FS + +D + L + Sbjct: 187 SDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKN 246 Query: 278 LTKRFGNLKNGVNDIKNHKWFATTD 302 +R + + H + +D Sbjct: 247 PAER-----ADLKQLMVHAFIKRSD 266 >4XCU-A nrPDB Length = 300 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 62/273 (22%), Positives = 115/273 (42%), Gaps = 30/273 (10%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVK-------HKETGNHFAMKILDKQKVVKL 83 WE P D+ K LG G FG+V+ + + + A+K+L Sbjct: 12 WEFPR------DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA--SD 63 Query: 84 KQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-------R 135 K + ++E +++ + ++ L LY+++E G + LR Sbjct: 64 KDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSS 123 Query: 136 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR 195 G S P A Q+ +YL S I+RDL N+L+ + +++ DFG A+ V Sbjct: 124 EGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHI 183 Query: 196 TW---TLCG--TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYE 249 + T G +++APE + + Y D W+ G+L++E+ G P+ +++ Sbjct: 184 DYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS 243 Query: 250 KIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + G ++ P H +L L+R ++R Sbjct: 244 LLREGHRMDRPPHCPPELYGLMRECWHAAPSQR 276 >6CKI-A nrPDB Length = 316 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 78/301 (25%), Positives = 127/301 (42%), Gaps = 47/301 (15%) Query: 39 AHLDQFERIK-TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 D ++ + LG G+ RV + T +A+KI++KQ E +L Sbjct: 9 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG---HIRSRVFREVEMLY 65 Query: 98 AVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 +++L F++ Y+V E + GG + SH+ + F+E A + + Sbjct: 66 QCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALD 125 Query: 157 YLHSLDLIYRDLKPENLLIDQQGY---IQVTDFGFAKRVK----------GRTWTLCGTP 203 +LH+ + +RDLKPEN+L + +++ DFG +K T CG+ Sbjct: 126 FLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSA 185 Query: 204 EYLAPEII-----LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ------------ 246 EY+APE++ + Y+K D W+LGV++Y + +GYPPF Sbjct: 186 EYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPAC 245 Query: 247 ---IYEKIVSGKVRFPS----HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 ++E I GK FP H S KDL+ LL D +R + H W Sbjct: 246 QNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQ 300 Query: 300 T 300 Sbjct: 301 G 301 >5H2U-A nrPDB Length = 267 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 114/263 (43%), Gaps = 13/263 (4%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++F + LG+G FG V K+ A+K++ + ++ + ++ +E + ++ + Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQ---SEIQAMKKLRH 61 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLH 159 ++ L +Y++ E + G + LR A Q+ YL Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLAPEIILSKGY 216 S + I+RDL N+L+ + +V DFG A+ +K + ++ APE + Y Sbjct: 122 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHY 181 Query: 217 NKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLL 274 + D W+ G+L++EM + G P+ + + ++ +G ++ P + L+ Sbjct: 182 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCW 241 Query: 275 QVDLTKR--FGNLKNGVNDIKNH 295 D +R F L+ ++ +H Sbjct: 242 CRDPEQRPTFKALRERLSSFTSH 264 >3DTC-A nrPDB Length = 271 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 67/267 (25%), Positives = 111/267 (41%), Gaps = 20/267 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ-IEHTLNEKRILQAVNF 101 + + +G G FG+V G+ A+K + Q IE+ E ++ + Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 P ++ L NL +VME+ GG + L R +A QI YLH Sbjct: 66 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYLHDE 124 Query: 162 DL---IYRDLKPENLLID--------QQGYIQVTDFGFAKRVKGRT-WTLCGTPEYLAPE 209 + I+RDLK N+LI +++TDFG A+ T + G ++APE Sbjct: 125 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWMAPE 184 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPSHFSSDLK 267 +I + ++K D W+ GVL++E+ G PF + + + K + PS Sbjct: 185 VIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFA 244 Query: 268 DLLRNLLQVDLTKR--FGNLKNGVNDI 292 L+ + D R F N+ + + I Sbjct: 245 KLMEDCWNPDPHSRPSFTNILDQLTTI 271 >2PL0-A nrPDB Length = 289 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 115/274 (41%), Gaps = 22/274 (8%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 +WE P + + ++ LG G FG V + + A+K L + + + Sbjct: 16 DEWEVPRET------LKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLKQGSMSP----DA 64 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARF 146 L E +++ + LV+L +Y++ EY+ G + L+ + + Sbjct: 65 FLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTINKLLD 123 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP--- 203 AAQI ++ + I+RDL+ N+L+ ++ DFG A+ ++ +T Sbjct: 124 MAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP 183 Query: 204 -EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPS 260 ++ APE I + D W+ G+L+ E+ G P+ ++ + + G ++ P Sbjct: 184 IKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPD 243 Query: 261 HFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDI 292 + +L L+R + R F L++ + D Sbjct: 244 NCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDF 277 >3BEA-A nrPDB Length = 333 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 127/310 (40%), Gaps = 41/310 (13%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH- 69 S + + F+ + + +KWE P + + KTLG G+FG+V+ G Sbjct: 21 SYEGNSYTFIDPTQLPYNEKWEFPR------NNLQFGKTLGAGAFGKVVEATAFGLGKED 74 Query: 70 ----FAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYV 124 A+K+L + E ++E +I+ + +V L + + ++ EY Sbjct: 75 AVLKVAVKMLK--STAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 132 Query: 125 PGGEMFSHLRRIGR--------------FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 170 G++ + LRR R S +++Q+ +L S + I+RD+ Sbjct: 133 CYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAA 192 Query: 171 ENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPE----YLAPEIILSKGYNKAVDWWAL 225 N+L+ ++ DFG A+ + + + G ++APE I Y D W+ Sbjct: 193 RNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSY 252 Query: 226 GVLIYEMAA-GYPPFFAD-QPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRF 282 G+L++E+ + G P+ + Y+ + G ++ P+ ++ +++ ++ T R Sbjct: 253 GILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR- 311 Query: 283 GNLKNGVNDI 292 I Sbjct: 312 ----PTFQQI 317 >5FM2-A nrPDB Length = 355 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 134/318 (42%), Gaps = 49/318 (15%) Query: 5 AAAKKGSEQESVKEFLAKAKEDFLK-----KWENPAQNTAHLDQFERIKTLGTGSFGRVM 59 + + G+ + S+ + D K KWE P +N KTLG G FG+V+ Sbjct: 28 SYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLV------LGKTLGEGEFGKVV 81 Query: 60 LV-----KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDN 114 K + A+K+L + ++ L+E +L+ VN P ++KL + + Sbjct: 82 KATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLSEFNVLKQVNHPHVIKLYGACSQD 139 Query: 115 SNLYMVMEYVPGGEMFSHLRRIGR------------------------FSEPHARFYAAQ 150 L +++EY G + LR + + +A Q Sbjct: 140 GPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQ 199 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGT-----PEY 205 I +YL + L++RDL N+L+ + ++++DFG ++ V + + ++ Sbjct: 200 ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKW 259 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFS 263 +A E + Y D W+ GVL++E+ G P+ P +++ + +G ++ P + S Sbjct: 260 MAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS 319 Query: 264 SDLKDLLRNLLQVDLTKR 281 ++ L+ + + KR Sbjct: 320 EEMYRLMLQCWKQEPDKR 337 >4K33-A nrPDB Length = 325 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 67/333 (20%), Positives = 133/333 (39%), Gaps = 40/333 (12%) Query: 1 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML 60 MG++ S+ +++ + KWE + K LG G+FG+V++ Sbjct: 1 MGSSHHHHHHSQDPPTLANVSELELPADPKWELSRA------RLTLGKPLGEGAFGQVVM 54 Query: 61 VKHKETGN-------HFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFK 112 + A+K+L K + ++E +++ + ++ L + Sbjct: 55 AEAIGIDKDRAAKPVTVAVKMLKDDA--TDKDLSDLVSEMEMMKMIGKHKNIINLLGACT 112 Query: 113 DNSNLYMVMEYVPGGEMFSHLRRIGR----------------FSEPHARFYAAQIVLTFE 156 LY+++EY G + LR + A Q+ E Sbjct: 113 QGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGME 172 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGT-----PEYLAPEII 211 YL S I+RDL N+L+ + +++ DFG A+ V + T +++APE + Sbjct: 173 YLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEAL 232 Query: 212 LSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDL 269 + Y D W+ GVL++E+ G P+ ++++ + G ++ P++ + DL + Sbjct: 233 FDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMI 292 Query: 270 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 +R ++R K V D+ +TD Sbjct: 293 MRECWHAAPSQR-PTFKQLVEDLDRVLTVTSTD 324 >2XNP-A nrPDB Length = 279 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 76/278 (27%), Positives = 134/278 (48%), Gaps = 21/278 (7%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 + + +E + T+GTGS+GR ++ K G K LD + + ++ + ++E +L+ Sbjct: 2 PSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEK-QMLVSEVNLLR 60 Query: 98 AVNFPFLVKLEYSFKDNSN--LYMVMEYVPGGEMFSHL----RRIGRFSEPHARFYAAQI 151 + P +V+ D +N LY+VMEY GG++ S + + E Q+ Sbjct: 61 ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL 120 Query: 152 VLTFEYLHSLD-----LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT---WTLCGTP 203 L + H +++RDLKP N+ +D + +++ DFG A+ + T T GTP Sbjct: 121 TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP 180 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV-RFPSHF 262 Y++PE + YN+ D W+LG L+YE+ A PPF A ++ KI GK R P + Sbjct: 181 YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY 240 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 S +L +++ +L + + V +I + Sbjct: 241 SDELNEIITRMLNLK-----DYHRPSVEEILENPLILE 273 >2OGV-A nrPDB Length = 317 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 125/306 (40%), Gaps = 37/306 (12%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH- 69 S + + F+ + + +KWE P + + KTLG G+FG+V+ G Sbjct: 13 SYEGNSYTFIDPTQLPYNEKWEFPR------NNLQFGKTLGAGAFGKVVEATAFGLGKED 66 Query: 70 ----FAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYV 124 A+K+L + E ++E +I+ + +V L + + ++ EY Sbjct: 67 AVLKVAVKMLK--STAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 124 Query: 125 PGGEMFSHLRRI----------GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLL 174 G++ + LRR +++Q+ +L S + I+RD+ N+L Sbjct: 125 CYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVL 184 Query: 175 IDQQGYIQVTDFGFAKRV-KGRTWTLCGTPE----YLAPEIILSKGYNKAVDWWALGVLI 229 + ++ DFG A+ + + + G ++APE I Y D W+ G+L+ Sbjct: 185 LTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILL 244 Query: 230 YEMAA-GYPPFFAD-QPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLK 286 +E+ + G P+ + Y+ + G ++ P+ ++ +++ ++ T R Sbjct: 245 WEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR----- 299 Query: 287 NGVNDI 292 I Sbjct: 300 PTFQQI 305 >3KUL-B nrPDB Length = 325 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 14/251 (5%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNH---FAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 + K +G+G G V + + G A+K L +Q L+E I+ Sbjct: 50 RIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALK--AGYTERQRRDFLSEASIMGQF 107 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYL 158 + P +++LE +V EY+ G + + LR G+F+ + YL Sbjct: 108 DHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYL 167 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---TWTLCG---TPEYLAPEIIL 212 L ++RDL N+L+D +V+DFG ++ ++ +T G + APE I Sbjct: 168 SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA 227 Query: 213 SKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 + ++ A D W+ GV+++E +A G P++ + + G ++ P L L+ Sbjct: 228 FRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLM 287 Query: 271 RNLLQVDLTKR 281 + D +R Sbjct: 288 LDCWHKDRAQR 298 >4PDO-A nrPDB Length = 299 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 115/270 (42%), Gaps = 21/270 (7%) Query: 31 WENPAQ------NTAHLDQFERIKTLGTGSFGRVMLVKHK-ETGNH---FAMKILDKQKV 80 +E+P Q H R K +G G FG V K +G A+K L Sbjct: 17 YEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLK--AG 74 Query: 81 VKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRF 139 KQ L E I+ + +++LE + ++ EY+ G + LR G F Sbjct: 75 YTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEF 134 Query: 140 SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---T 196 S I +YL +++ ++RDL N+L++ +V+DFG ++ ++ T Sbjct: 135 SVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAT 194 Query: 197 WTLCG---TPEYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIV 252 +T G + APE I + + A D W+ G++++E M G P++ ++ + I Sbjct: 195 YTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAIN 254 Query: 253 SG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 G ++ P S + L+ Q + +R Sbjct: 255 DGFRLPTPMDCPSAIYQLMMQCWQQERARR 284 >4BGQ-A nrPDB Length = 304 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 80/297 (26%), Positives = 132/297 (44%), Gaps = 44/297 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +++FE + +G G++G V+ +HKET A+K K + E TL E ++L+ + Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKF-KDSEENEEVKETTLRELKMLRTLK 69 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH-ARFYAAQIVLTFEYLH 159 +V+L+ +F+ LY+V EYV M L + P + Y Q++ + H Sbjct: 70 QENIVELKEAFRRRGKLYLVFEYVEK-NMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 128 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV----KGRTWTLCGTPEYLAPEIILSKG 215 D+++RD+KPENLLI +++ DFGFA+ + T Y +PE++L Sbjct: 129 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAP 188 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH-------------- 261 Y K+VD W++G ++ E++ G P F + I I PS Sbjct: 189 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 248 Query: 262 ------------------FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 +S L DL++NLL++D R+ NH F T Sbjct: 249 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLT-----EQCLNHPTFQT 300 >5KKR-C nrPDB Length = 395 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 76/346 (21%), Positives = 141/346 (40%), Gaps = 55/346 (15%) Query: 3 NAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVK 62 N A +K E+ + E K E FL + + + D FE+I LG G+ G V V Sbjct: 31 NLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKD--DDFEKISELGAGNGGVVFKVS 88 Query: 63 HKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVME 122 HK +G A K++ + +K + E ++L N P++V +F + + + ME Sbjct: 89 HKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICME 146 Query: 123 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL-HSLDLIYRDLKPENLLIDQQGYI 181 ++ GG + L++ GR E + ++ YL +++RD+KP N+L++ +G I Sbjct: 147 HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI 206 Query: 182 QVTDFGFAKR-VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240 ++ DFG + + + + GT Y++PE + Y+ D W++G+ + EMA G P Sbjct: 207 KLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIP 266 Query: 241 ---------------------------------------ADQPIQIYEKIVSGKVRFPSH 261 + P+ I+E + P Sbjct: 267 PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPK 326 Query: 262 FSS-----DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 S + +D + L + +R + + H + +D Sbjct: 327 LPSAVFSLEFQDFVNKCLIKNPAER-----ADLKQLMVHAFIKRSD 367 >5DBX-A nrPDB Length = 328 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 121/303 (39%), Gaps = 35/303 (11%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 D +E + +G+G+ V K A+K ++ +K ++ L E + + Sbjct: 7 PICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS--MDELLKEIQAMS 64 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL--------RRIGRFSEPHARFYAA 149 + P +V SF L++VM+ + GG M + + G E Sbjct: 65 QCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK 124 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--------KGRTWTLCG 201 +++ +YLH I+RDLK N+L+ + G +Q+ DFG + + G Sbjct: 125 EVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVG 184 Query: 202 TPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS 260 TP ++APE++ +GY+ D W+ G+ E+A G P+ P+++ + Sbjct: 185 TPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLE 244 Query: 261 ----------HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF-ATTDWIAIYQR 309 + + LL LQ D +KR ++ K+F + + ++ Sbjct: 245 TGVEDKEMMKKYGKSFRKLLSLCLQKDPSKR-----PTAAELLKCKFFQKAKNREYLIEK 299 Query: 310 KVE 312 + Sbjct: 300 LLT 302 >4BBM-A nrPDB Length = 331 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 78/308 (25%), Positives = 134/308 (43%), Gaps = 43/308 (13%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT-LNEKRILQAV 99 ++++E + +G GS+G VM ++K+TG A+K + K ++ + E ++L+ + Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKF--LESDDDKMVKKIAMREIKLLKQL 81 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 LV L K Y+V E+V + + Y QI+ + H Sbjct: 82 RHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCH 141 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTW-TLCGTPEYLAPEIILSK-G 215 S ++I+RD+KPEN+L+ Q G +++ DFGFA+ + G + T Y APE+++ Sbjct: 142 SHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVK 201 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG-------------------KV 256 Y KAVD WA+G L+ EM G P F D I I+ V Sbjct: 202 YGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV 261 Query: 257 RFP------------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI 304 R P S + DL + L +D KR ++ +H +F + Sbjct: 262 RLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKR-----PFCAELLHHDFFQMDGFA 316 Query: 305 AIYQRKVE 312 + ++++ Sbjct: 317 ERFSQELQ 324 >5VO2-A nrPDB Length = 300 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 67/309 (21%), Positives = 127/309 (41%), Gaps = 31/309 (10%) Query: 31 WENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 WE P ++ ++ +G+G+ G V L + G A+K + K +K Sbjct: 7 WEVP------FEEILDLQWVGSGAQGAVFLGRF--HGEEVAVKKVRDLKETDIKH----- 53 Query: 91 NEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 150 L+ + P ++ + ++ME+ G+++ LR + ++ Sbjct: 54 -----LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMG 108 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAP 208 I YLH +I+RDLK N+LI ++++DFG +K + ++ + GT ++AP Sbjct: 109 IAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAP 168 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF--PSHFSSDL 266 E+I ++ ++ VD W+ GV+++E+ G P+ I + S + PS Sbjct: 169 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGF 228 Query: 267 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTS 326 K LLR R I H A+ D + E F + + + Sbjct: 229 KILLRQCWNSKPRNR-----PSFRQILLHLDIASAD---VLSTPQETYFKSQAEWREEVK 280 Query: 327 -NFDDYEEE 334 +F+ + E Sbjct: 281 LHFEKIKSE 289 >2HK5-A nrPDB Length = 270 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 56/275 (20%), Positives = 117/275 (42%), Gaps = 17/275 (6%) Query: 28 LKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIE 87 K WE A + + K LG G FG V + + + A+K + + +E Sbjct: 2 QKPWEKDAWEIPR-ESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS----VE 55 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHAR 145 L E +++ + LVKL +Y++ E++ G + L+ + P Sbjct: 56 AFLAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLI 114 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP-- 203 ++AQI ++ + I+RDL+ N+L+ ++ DFG A+ ++ +T Sbjct: 115 DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKF 174 Query: 204 --EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFP 259 ++ APE I + D W+ G+L+ E+ G P+ ++ + G ++ P Sbjct: 175 PIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP 234 Query: 260 SHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDI 292 + +L +++ + +R F +++ ++D Sbjct: 235 ENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDF 269 >3KRL-A nrPDB Length = 335 Score = 233 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 60/301 (19%), Positives = 125/301 (41%), Gaps = 38/301 (12%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH- 69 S + + F+ + + +KWE P + + KTLG G+FG+V+ G Sbjct: 21 SYEGNSYTFIDPTQLPYNEKWEFPR------NNLQFGKTLGAGAFGKVVEATAFGLGKED 74 Query: 70 ----FAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYV 124 A+K+L + E ++E +I+ + +V L + + ++ EY Sbjct: 75 AVLKVAVKMLK--STAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 132 Query: 125 PGGEMFSHLRRIGR----------------FSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 G++ + LRR S +++Q+ +L S + I+RD+ Sbjct: 133 CYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDV 192 Query: 169 KPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPE----YLAPEIILSKGYNKAVDWW 223 N+L+ ++ DFG A+ + + + G ++APE I Y D W Sbjct: 193 AARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVW 252 Query: 224 ALGVLIYEMAA-GYPPFFAD-QPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTK 280 + G+L++E+ + G P+ + Y+ + G ++ P+ ++ +++ ++ T Sbjct: 253 SYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTH 312 Query: 281 R 281 R Sbjct: 313 R 313 >4R7H-A nrPDB Length = 343 Score = 233 bits (595), Expect = 8e-62, Method: Composition-based stats. Identities = 59/315 (18%), Positives = 125/315 (39%), Gaps = 45/315 (14%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH- 69 S + + F+ + + +KWE P + + KTLG G+FG+V+ G Sbjct: 25 SYEGNSYTFIDPTQLPYNEKWEFPR------NNLQFGKTLGAGAFGKVVEATAFGLGKED 78 Query: 70 ----FAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYV 124 A+K+L + E ++E +I+ + +V L + + ++ EY Sbjct: 79 AVLKVAVKMLK--STAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 136 Query: 125 PGGEMFSHLRRI-----------------------GRFSEPHARFYAAQIVLTFEYLHSL 161 G++ + LRR +++Q+ +L S Sbjct: 137 TYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASK 196 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPE----YLAPEIILSKGY 216 + I+RD+ N+L+ ++ DFG A+ + + + G ++APE I Y Sbjct: 197 NCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVY 256 Query: 217 NKAVDWWALGVLIYEMAA-GYPPFFAD-QPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNL 273 D W+ G+L++E+ + G P+ + Y+ + G ++ P+ ++ +++ Sbjct: 257 TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQAC 316 Query: 274 LQVDLTKRFGNLKNG 288 ++ T R + Sbjct: 317 WALEPTHRPTFQQIT 331 >4KRC-A nrPDB Length = 317 Score = 233 bits (595), Expect = 9e-62, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 123/303 (40%), Gaps = 52/303 (17%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 QF++++ LG G++ V +K TG + A+K + + E +++ + Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST--AIREISLMKELKHE 63 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG------RFSEPHARFYAAQIVLTFE 156 +V+L + L +V E++ ++ ++ +++ Q++ Sbjct: 64 NIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIILS 213 + H +++RDLKP+NLLI+++G +++ DFG A+ T T Y AP++++ Sbjct: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 Query: 214 -KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI--VSG---------------- 254 + Y+ ++D W+ G ++ EM G P F + + I + G Sbjct: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 Query: 255 ----KVRFPSHFSSDLK------------DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + R P L+ D L LLQ++ R +H WF Sbjct: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHPWF 297 Query: 299 ATT 301 A Sbjct: 298 AEY 300 >5EG3-A nrPDB Length = 334 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 124/295 (42%), Gaps = 40/295 (13%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV----KHKETGNH---FAMKILDKQKVV 81 KWE P D+ K LG G+FG+V++ K+ A+K+L Sbjct: 28 PKWEFPR------DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA-- 79 Query: 82 KLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-- 138 K + ++E +++ + ++ L + + LY+++ Y G + +LR Sbjct: 80 TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPG 139 Query: 139 --------------FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184 + Q+ EYL S I+RDL N+L+ + +++ Sbjct: 140 MELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIA 199 Query: 185 DFGFAKRVKG-----RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPP 238 DFG A+ + T +++APE + + Y D W+ GVL++E+ G P Sbjct: 200 DFGLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSP 259 Query: 239 FFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 + ++++ + G ++ P++ +++L ++R+ ++R K V D+ Sbjct: 260 YPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR-PTFKQLVEDL 313 >4XUF-A nrPDB Length = 297 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 62/289 (21%), Positives = 128/289 (44%), Gaps = 45/289 (15%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH---KETG--NHFAMKILDKQKVVKLK 84 KWE P + E K LG+G+FG+VM +TG A+K+L ++ Sbjct: 3 KWEFPR------ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA--DSS 54 Query: 85 QIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEP 142 + E ++E +++ + + +V L + + +Y++ EY G++ ++LR + +FSE Sbjct: 55 EREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSED 114 Query: 143 HARF----------------------YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 + +A Q+ E+L ++RDL N+L+ Sbjct: 115 EIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKV 174 Query: 181 IQVTDFGFAKRV-KGRTWTLCGTPE----YLAPEIILSKGYNKAVDWWALGVLIYEMAA- 234 +++ DFG A+ + + + G ++APE + Y D W+ G+L++E+ + Sbjct: 175 VKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSL 234 Query: 235 GYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 G P+ + K++ K+ P + + ++ ++++ D KR Sbjct: 235 GVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKR 283 >3HKO-A nrPDB Length = 345 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 75/318 (23%), Positives = 133/318 (41%), Gaps = 62/318 (19%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVK--LKQIEHTLNEKRILQAV 99 ++ +G GS+G V + +T A+KI++K K+ + K +E E R+++ + Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL-------------------------- 133 + P + +L ++D + +VME GG + L Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 134 ------------RRIGRF--SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI--DQ 177 R F E QI YLH+ + +RD+KPEN L ++ Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNK 205 Query: 178 QGYIQVTDFGFAKRV----KGRTW---TLCGTPEYLAPEIIL--SKGYNKAVDWWALGVL 228 I++ DFG +K G + T GTP ++APE++ ++ Y D W+ GVL Sbjct: 206 SFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVL 265 Query: 229 IYEMAAGYPPFFADQPIQIYEKIVSGKVRF--PSH--FSSDLKDLLRNLLQVDLTKRFGN 284 ++ + G PF ++++ K+ F P++ S +DLL NLL ++ +RF Sbjct: 266 LHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDA 325 Query: 285 LKNGVNDIKNHKWFATTD 302 ++ H W + Sbjct: 326 MR-----ALQHPWISQFS 338 >3G0E-A nrPDB Length = 336 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 123/308 (39%), Gaps = 45/308 (14%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV-----KHKETGNHFAMK 73 ++ + + KWE P ++ KTLG G+FG+V+ + A+K Sbjct: 29 YIDPTQLPYDHKWEFPR------NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVK 82 Query: 74 ILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSH 132 +L L + E ++E ++L + N +V L + ++ EY G++ + Sbjct: 83 MLKPSA--HLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNF 140 Query: 133 LRRIG------------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLL 174 LRR ++ Q+ +L S + I+RDL N+L Sbjct: 141 LRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNIL 200 Query: 175 IDQQGYIQVTDFGFAKRVK-GRTWTLCGTPE----YLAPEIILSKGYNKAVDWWALGVLI 229 + ++ DFG A+ +K + + G ++APE I + Y D W+ G+ + Sbjct: 201 LTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFL 260 Query: 230 YEMAA-GYPPFFADQ-PIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLK 286 +E+ + G P+ + Y+ I G ++ P H +++ D+++ D KR Sbjct: 261 WELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKR----- 315 Query: 287 NGVNDIKN 294 I Sbjct: 316 PTFKQIVQ 323 >4GS6-A nrPDB Length = 315 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 63/264 (23%), Positives = 118/264 (44%), Gaps = 24/264 (9%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 + E + +G G+FG V K + A+K ++ + + + + E R L VN Sbjct: 8 YKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESES-----ERKAFIVELRQLSRVN 60 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRF---SEPHARFYAAQIVLTFEY 157 P +VKL + + + +VMEY GG +++ L + HA + Q Y Sbjct: 61 HPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAY 118 Query: 158 LHSLD---LIYRDLKPENLLIDQQGYI-QVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS 213 LHS+ LI+RDLKP NLL+ G + ++ DFG A ++ G+ ++APE+ Sbjct: 119 LHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEG 178 Query: 214 KGYNKAVDWWALGVLIYEMAAGYPPFF--ADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 Y++ D ++ G++++E+ PF +I + +G + + ++ L+ Sbjct: 179 SNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLM 238 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKN 294 D ++R + +I Sbjct: 239 TRCWSKDPSQR-----PSMEEIVK 257 >3LM0-A nrPDB Length = 327 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 83/325 (25%), Positives = 142/325 (43%), Gaps = 34/325 (10%) Query: 36 QNTAHLDQFERI--KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK 93 Q+ + + F + K LG G F V K TG +A K L K++ + + E L+E Sbjct: 21 QSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAE-ILHEI 79 Query: 94 RILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL--RRIGRFSEPHARFYAAQ 150 +L+ P ++ L +++ S + +++EY GGE+FS SE Q Sbjct: 80 AVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQ 139 Query: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQ---QGYIQVTDFGFAKRVKG--RTWTLCGTPEY 205 I+ YLH ++++ DLKP+N+L+ G I++ DFG ++++ + GTPEY Sbjct: 140 ILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEY 199 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH---- 261 LAPEI+ A D W +G++ Y + PF + + Y I V + Sbjct: 200 LAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSS 259 Query: 262 FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG 321 S D +++LL + KR +H W D+ ++ Sbjct: 260 VSQLATDFIQSLLVKNPEKR-----PTAEICLSHSWLQQWDFENLFH------------- 301 Query: 322 PGDTSNFDDYEEEEIRVSINEKCGK 346 P +TS+ ++ +R S +K K Sbjct: 302 PEETSSSSQTQDHSVRSS-EDKTSK 325 >1U5R-A nrPDB Length = 348 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 61/264 (23%), Positives = 109/264 (41%), Gaps = 15/264 (5%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F ++ +G GSFG V + A+K + ++ + + E R LQ + P Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGG--EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 ++ + ++VMEY G ++ E + YLHS Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLEV--HKKPLQEVEIAAVTHGALQGLAYLHSH 173 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL---SKGYNK 218 ++I+RD+K N+L+ + G +++ DFG A + + GTP ++APE+IL Y+ Sbjct: 174 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP-ANSFVGTPYWMAPEVILAMDEGQYDG 232 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSHFSSDLKDLLRNLLQV 276 VD W+LG+ E+A PP F + I + H+S ++ + + LQ Sbjct: 233 KVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQK 292 Query: 277 DLTKRFGNLKNGVNDIKNHKWFAT 300 R + H++ Sbjct: 293 IPQDR-----PTSEVLLKHRFVLR 311 >5X02-A nrPDB Length = 347 Score = 230 bits (588), Expect = 6e-61, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 132/314 (42%), Gaps = 54/314 (17%) Query: 26 DFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH---KETG--NHFAMKILDKQKV 80 ++ KWE P + E K LG+G+FG+VM +TG A+K+L ++ Sbjct: 38 EYDLKWEFPR------ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA- 90 Query: 81 VKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGR 138 + E ++E +++ + + +V L + + +Y++ EY G++ ++LR + + Sbjct: 91 -DSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREK 149 Query: 139 FSEPHARF----------------------YAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 FSE + +A Q+ E+L ++RDL N+L+ Sbjct: 150 FSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVT 209 Query: 177 QQGYIQVTDFGFAKRV-KGRTWTLCGTPE----YLAPEIILSKGYNKAVDWWALGVLIYE 231 +++ DFG A+ + + + G ++APE + Y D W+ G+L++E Sbjct: 210 HGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWE 269 Query: 232 MAA-GYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDLTKR------- 281 + + G P+ + K++ K+ P + + ++ ++++ D KR Sbjct: 270 IFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLT 329 Query: 282 --FGNLKNGVNDIK 293 G + Sbjct: 330 SFLGCQLADAEEAM 343 >3QGY-A nrPDB Length = 286 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 57/259 (22%), Positives = 118/259 (45%), Gaps = 14/259 (5%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 + ++ +G+G FG V L + A+K + + + + + + E ++ ++ P Sbjct: 28 ELTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIKEGSMSE----DDFIEEAEVMMKLSHP 82 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSL 161 LV+L + + + +V E++ G + +LR + G F+ + YL Sbjct: 83 KLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEA 142 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-LCGTP---EYLAPEIILSKGYN 217 +I+RDL N L+ + I+V+DFG + V +T GT ++ +PE+ Y+ Sbjct: 143 CVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYS 202 Query: 218 KAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQ 275 D W+ GVL++E+ + G P+ ++ E I +G ++ P S+ + ++ + + Sbjct: 203 SKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWK 262 Query: 276 VDLTKR--FGNLKNGVNDI 292 R F L + +I Sbjct: 263 ERPEDRPAFSRLLRQLAEI 281 >4H1J-A nrPDB Length = 293 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 61/261 (23%), Positives = 116/261 (44%), Gaps = 15/261 (5%) Query: 48 KTLGTGSFGRVMLVK---HKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFL 104 + LG G FG V HK + A+K K + K E ++E I++ ++ P + Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK--EKFMSEAVIMKNLDHPHI 87 Query: 105 VKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLHSLDL 163 VKL ++ +++ME P GE+ +L R Y+ QI YL S++ Sbjct: 88 VKLIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINC 146 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC-GTP---EYLAPEIILSKGYNKA 219 ++RD+ N+L+ +++ DFG ++ ++ + T ++++PE I + + A Sbjct: 147 VHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTA 206 Query: 220 VDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVD 277 D W V ++E+ + G PFF + + + G ++ P L L+ D Sbjct: 207 SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYD 266 Query: 278 LTK--RFGNLKNGVNDIKNHK 296 + RF L ++D+ + Sbjct: 267 PSDRPRFTELVCSLSDVYQME 287 >5X5O-A nrPDB Length = 310 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 61/252 (24%), Positives = 105/252 (41%), Gaps = 19/252 (7%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 D + + G GSFG V K A+K L K E IL Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-----------IEKEAEILS 59 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARFYAAQIVLTF 155 ++ +++ + N +V EY G ++ ++ R H +A + Sbjct: 60 VLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGM 119 Query: 156 EYLHSL---DLIYRDLKPENLLIDQQGYIQVTDFGFAK-RVKGRTWTLCGTPEYLAPEII 211 YLH +I+RDLK N++I G +++ DFG ++ +L GT ++APE+I Sbjct: 120 HYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVI 179 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDL 269 S ++ D ++ GV+++EM PF + +Q+ +V ++ PS +L Sbjct: 180 QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 239 Query: 270 LRNLLQVDLTKR 281 L + D KR Sbjct: 240 LHQCWEADAKKR 251 >4HZS-A nrPDB Length = 341 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 58/253 (22%), Positives = 102/253 (40%), Gaps = 14/253 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVK-HKETGNHF--AMKILDKQKVVKLKQIEHTLNEKRILQA 98 ++ LG GSFG V + +G A+K L + + + ++ + E + + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEY 157 ++ L++L + MV E P G + LR+ G F YA Q+ Y Sbjct: 72 LDHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGY 130 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC------GTPEYLAPEII 211 L S I+RDL NLL+ + +++ DFG + + + APE + Sbjct: 131 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 190 Query: 212 LSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVS--GKVRFPSHFSSDLKD 268 ++ ++ A D W GV ++EM G P+ QI KI ++ P D+ + Sbjct: 191 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 250 Query: 269 LLRNLLQVDLTKR 281 ++ R Sbjct: 251 VMVQCWAHKPEDR 263 >1AD5-A nrPDB Length = 438 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 59/293 (20%), Positives = 120/293 (40%), Gaps = 19/293 (6%) Query: 6 AAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKE 65 KKG++ K + K WE A + + K LG G FG V + + + Sbjct: 147 HYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPR-ESLKLEKKLGAGQFGEVWMATYNK 205 Query: 66 TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVP 125 A+K + + +E L E +++ + LVKL +Y++ E++ Sbjct: 206 -HTKVAVKTMKPGSMS----VEAFLAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMA 259 Query: 126 GGEMFSHLR--RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 183 G + L+ + P ++AQI ++ + I+RDL+ N+L+ ++ Sbjct: 260 KGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKI 319 Query: 184 TDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFAD 242 DFG A+ ++ APE I + D W+ G+L+ E+ G P+ Sbjct: 320 ADFGLARVGAKFP------IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGM 373 Query: 243 QPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDI 292 ++ + G ++ P + +L +++ + +R F +++ ++D Sbjct: 374 SNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDF 426 >2GCD-A nrPDB Length = 309 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 61/264 (23%), Positives = 109/264 (41%), Gaps = 15/264 (5%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F ++ +G GSFG V + A+K + ++ + + E R LQ + P Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGG--EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 ++ + ++VMEY G ++ E + YLHS Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEV--HKKPLQEVEIAAVTHGALQGLAYLHSH 134 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL---SKGYNK 218 ++I+RD+K N+L+ + G +++ DFG A + + GTP ++APE+IL Y+ Sbjct: 135 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP-ANSFVGTPYWMAPEVILAMDEGQYDG 193 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSHFSSDLKDLLRNLLQV 276 VD W+LG+ E+A PP F + I + H+S ++ + + LQ Sbjct: 194 KVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQK 253 Query: 277 DLTKRFGNLKNGVNDIKNHKWFAT 300 R + H++ Sbjct: 254 IPQDR-----PTSEVLLKHRFVLR 272 >1LUF-A nrPDB Length = 343 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 52/280 (18%), Positives = 103/280 (36%), Gaps = 38/280 (13%) Query: 42 DQFERIKTLGTGSFGRVMLVKHK-----ETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 + E ++ +G G+FGRV + E A+K+L ++ ++ E ++ Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQ--ADFQREAALM 104 Query: 97 QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-------------------- 136 + P +VKL + ++ EY+ G++ LR + Sbjct: 105 AEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVS 164 Query: 137 ----GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV 192 S A Q+ YL ++RDL N L+ + +++ DFG ++ + Sbjct: 165 SPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI 224 Query: 193 KGRTWTLCG-----TPEYLAPEIILSKGYNKAVDWWALGVLIYEMA-AGYPPFFADQPIQ 246 + ++ PE I Y D WA GV+++E+ G P++ + Sbjct: 225 YSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEE 284 Query: 247 IYEKIVSGK-VRFPSHFSSDLKDLLRNLLQVDLTKRFGNL 285 + + G + P + +L +L+R R Sbjct: 285 VIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFC 324 >1U54-B nrPDB Length = 291 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 62/268 (23%), Positives = 107/268 (39%), Gaps = 17/268 (6%) Query: 32 ENPAQNTAHL---DQFERIKTLGTGSFGRVMLVK-HKETGNHF--AMKILDKQKVVKLKQ 85 E P Q+ L ++ LG GSFG V + +G A+K L + + + Sbjct: 5 EGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEA 64 Query: 86 IEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHA 144 ++ + E + +++ L++L + MV E P G + LR+ G F Sbjct: 65 MDDFIREVNAMHSLDHRNLIRLYGVVLT-PPMKMVTELAPLGSLLDRLRKHQGHFLLGTL 123 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC---- 200 YA Q+ YL S I+RDL NLL+ + +++ DFG + + Sbjct: 124 SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEH 183 Query: 201 --GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVS--GK 255 + APE + ++ ++ A D W GV ++EM G P+ QI KI + Sbjct: 184 RKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGER 243 Query: 256 VRFPSHFSSDLKDLLRNLLQVDLTKRFG 283 + P D+ +++ R Sbjct: 244 LPRPEDCPQDIYNVMVQCWAHKPEDRPT 271 >1FVR-A nrPDB Length = 327 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 113/272 (41%), Gaps = 25/272 (9%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHF--AMKILDKQKVVKLKQIEHTLNEKRILQAV 99 + + +G G+FG+V+ + K+ G A+K + + E +L + Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK--EYASKDDHRDFAGELEVLCKL 82 Query: 100 -NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG----------------RFSEP 142 + P ++ L + + LY+ +EY P G + LR+ S Sbjct: 83 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG- 201 +AA + +YL I+RDL N+L+ + ++ DFG ++ + G Sbjct: 143 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGR 202 Query: 202 -TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRF 258 ++A E + Y D W+ GVL++E+ + G P+ ++YEK+ G ++ Sbjct: 203 LPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEK 262 Query: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 290 P + ++ DL+R + +R + V+ Sbjct: 263 PLNCDDEVYDLMRQCWREKPYERPSFAQILVS 294 >6E2O-A nrPDB Length = 295 Score = 228 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 78/258 (30%), Positives = 127/258 (49%), Gaps = 15/258 (5%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 LG G++G V + A+K + ++ + + E + + + +V+ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPER---DSRYSQPLHEEIALHKHLKHKNIVQYL 85 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRI---GRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 SF +N + + ME VPGG + + LR + +E FY QI+ +YLH +++ Sbjct: 86 GSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVH 145 Query: 166 RDLKPENLLIDQ-QGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILS--KGYNKA 219 RD+K +N+LI+ G ++++DFG +KR+ G T T GT +Y+APEII +GY KA Sbjct: 146 RDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKA 205 Query: 220 VDWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIVSGKV--RFPSHFSSDLKDLLRNLLQV 276 D W+LG I EMA G PPF+ +P K+ KV P S++ K + + Sbjct: 206 ADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEP 265 Query: 277 DLTKRFGNLKNGVNDIKN 294 D KR V++ Sbjct: 266 DPDKRACANDLLVDEFLK 283 >4AU8-A nrPDB Length = 296 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 127/293 (43%), Gaps = 42/293 (14%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++E+++ +G G++G V K++ET A+K + L E +L+ + Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKHK 65 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHSL 161 +V+L + L +V E+ ++ + G + + Q++ + HS Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 124 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIILSKG-YN 217 ++++RDLKP+NLLI++ G +++ DFG A+ + R ++ T Y P+++ Y+ Sbjct: 125 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 184 Query: 218 KAVDWWALGVLIYEMA-AGYPPFFADQPIQIYEKI-----------------VSGKVRFP 259 ++D W+ G + E+A AG P F + ++I + +P Sbjct: 185 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 244 Query: 260 ------------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 ++ +DLL+NLL+ + +R + H +F+ Sbjct: 245 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSD 292 >3CJF-A nrPDB Length = 309 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 40/294 (13%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVK-----HKETGNHFAMKILDKQKVVKL 83 KWE P D+ K LG G+FG+V+ T A+K+L + Sbjct: 20 SKWEFPR------DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGA--TH 71 Query: 84 KQIEHTLNEKRILQAV-NFPFLVKLEYSFKD-NSNLYMVMEYVPGGEMFSHLRRIGR--- 138 + ++E +IL + + +V L + L +++E+ G + ++LR Sbjct: 72 SEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV 131 Query: 139 ---------FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA 189 + H Y+ Q+ E+L S I+RDL N+L+ ++ +++ DFG A Sbjct: 132 PYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 191 Query: 190 KRV-KGRTWTLCGTPE----YLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQ 243 + + K + G ++APE I + Y D W+ GVL++E+ + G P+ + Sbjct: 192 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 251 Query: 244 PIQIY-EKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNH 295 + + ++ G ++R P + + ++ + + + ++R +++ H Sbjct: 252 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR-----PTFSELVEH 300 >3EQC-A nrPDB Length = 360 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 74/340 (21%), Positives = 138/340 (40%), Gaps = 55/340 (16%) Query: 9 KGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGN 68 K E+ + E K E FL + + + D FE+I LG G+ G V V HK +G Sbjct: 2 KKLEELELDEQQRKRLEAFLTQKQKVGELKD--DDFEKISELGAGNGGVVFKVSHKPSGL 59 Query: 69 HFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGE 128 A K++ + +K + E ++L N P++V +F + + + ME++ GG Sbjct: 60 VMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGS 117 Query: 129 MFSHLRRIGRFSEPHARFYAAQIVLTFEYL-HSLDLIYRDLKPENLLIDQQGYIQVTDFG 187 + L++ GR E + ++ YL +++RD+KP N+L++ +G I++ DFG Sbjct: 118 LDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFG 177 Query: 188 FAKR-VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF------ 240 + + + + GT Y++PE + Y+ D W++G+ + EMA G P Sbjct: 178 VSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 237 Query: 241 ---------------------------------ADQPIQIYEKIVSGKVRFPSHFSS--- 264 + P+ I+E + P S Sbjct: 238 LELMFGCQVEGDAAETPPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVF 297 Query: 265 --DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 + +D + L + +R + + H + +D Sbjct: 298 SLEFQDFVNKCLIKNPAER-----ADLKQLMVHAFIKRSD 332 >5GRN-A nrPDB Length = 356 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 62/311 (19%), Positives = 126/311 (40%), Gaps = 48/311 (15%) Query: 11 SEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVK-----HKE 65 S ++ + + +WE P D + LG+G+FG+V+ + Sbjct: 21 SPDGHEYIYVDPMQLPYDSRWEFPR------DGLVLGRVLGSGAFGKVVEGTAYGLSRSQ 74 Query: 66 TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYV 124 A+K+L KQ ++E +I+ + +V L + + +Y++ EY Sbjct: 75 PVMKVAVKMLKPTARSSEKQ--ALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYC 132 Query: 125 PGGEMFSHLRR--------------------------IGRFSEPHARFYAAQIVLTFEYL 158 G++ ++L + + + Q+ E+L Sbjct: 133 FYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFL 192 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGT----PEYLAPEIILS 213 S + ++RDL N+L+ Q +++ DFG A+ + + G+ +++APE I Sbjct: 193 ASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFD 252 Query: 214 KGYNKAVDWWALGVLIYEMAA-GYPPFFADQ-PIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 Y D W+ G+L++E+ + G P+ Y KI SG ++ P H +S++ +++ Sbjct: 253 NLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIM 312 Query: 271 RNLLQVDLTKR 281 + KR Sbjct: 313 VKCWNSEPEKR 323 >3SXS-A nrPDB Length = 268 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 64/263 (24%), Positives = 120/263 (45%), Gaps = 16/263 (6%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNH-FAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++ +K LG+G FG V L K K G + A+K++ + + + + E + + ++ Sbjct: 8 EEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSE----DEFFQEAQTMMKLS 61 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP-HARFYAAQIVLTFEYLH 159 P LVK +Y+V EY+ G + ++LR G+ EP + +L Sbjct: 62 HPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLE 121 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW-TLCGTP---EYLAPEIILSKG 215 S I+RDL N L+D+ ++V+DFG + V + + GT ++ APE+ Sbjct: 122 SHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFK 181 Query: 216 YNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGKVRFPSHF-SSDLKDLLRNL 273 Y+ D WA G+L++E+ + G P+ ++ K+ G + H S + ++ + Sbjct: 182 YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSC 241 Query: 274 LQVDLTKR--FGNLKNGVNDIKN 294 KR F L + + ++ Sbjct: 242 WHELPEKRPTFQQLLSSIEPLRE 264 >4X7Q-B nrPDB Length = 312 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 74/292 (25%), Positives = 127/292 (43%), Gaps = 30/292 (10%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN---EKRILQAV 99 ++ LG G FG V A+K++ + +V+ + ++ E +L V Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 100 N----FPFLVKLEYSFKDNSNLYMVMEY-VPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 P +++L F+ +V+E +P ++F ++ G E +R + Q+V Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 155 FEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTWT-LCGTPEYLAPEIIL 212 ++ HS +++RD+K EN+LID ++G ++ DFG + +T GT Y PE I Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWIS 211 Query: 213 SKGYNK-AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 271 Y+ W+LG+L+Y+M G PF DQ I+ ++ FP+H S D L+R Sbjct: 212 RHQYHALPATVWSLGILLYDMVCGDIPFERDQE------ILEAELHFPAHVSPDCCALIR 265 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPG 323 L + R + +I W T + P P GP Sbjct: 266 RCLAPKPSSR-----PSLEEILLDPWMQTP--------AEDVPLNPSKGGPA 304 >4IC8-A nrPDB Length = 442 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 75/377 (19%), Positives = 153/377 (40%), Gaps = 31/377 (8%) Query: 4 AAAAKKGSEQESVKEFLAKAKEDF-LKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVK 62 +A + E + A ++ L K + D++E I+T+G G++G V + Sbjct: 16 SAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSAR 75 Query: 63 HKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFK------DNSN 116 + TG A+K + V + + TL E +IL+ ++ ++ + + + Sbjct: 76 RRLTGQQVAIKKIPNAFDV-VTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKS 134 Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 +Y+V++ + ++ + + H R++ Q++ +Y+HS +I+RDLKP NLL++ Sbjct: 135 VYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN 193 Query: 177 QQGYIQVTDFGFAKRV-------KGRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVL 228 + +++ DFG A+ + + T Y APE++LS Y +A+D W++G + Sbjct: 194 ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCI 253 Query: 229 IYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF-----SSDLKDLLRNLLQVDL---TK 280 EM A F + + I+ + ++ +++L Sbjct: 254 FGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWET 313 Query: 281 RFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN----FD-DYEEEE 335 + + + PF+ K+ P D + FD ++ E Sbjct: 314 VYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREA 373 Query: 336 -IRVSINEKCGKEFSEF 351 R I E E +F Sbjct: 374 LTRERIKEAIVAEIEDF 390 >5TUR-A nrPDB Length = 404 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 73/278 (26%), Positives = 132/278 (47%), Gaps = 21/278 (7%) Query: 34 PAQNTAHLD-QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN- 91 P + L+ Q++ LG+G FG V A+K ++K ++ ++ + Sbjct: 118 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 177 Query: 92 --EKRILQAVNFPF--LVKLEYSFKDNSNLYMVMEYV-PGGEMFSHLRRIGRFSEPHARF 146 E +L+ V+ F +++L F+ + +++E P ++F + G E AR Sbjct: 178 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 237 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTWT-LCGTPE 204 + Q++ + H+ +++RD+K EN+LID +G +++ DFG +K +T GT Sbjct: 238 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 297 Query: 205 YLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS 263 Y PE I Y ++ W+LG+L+Y+M G PF D E+I+ G+V F S Sbjct: 298 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVS 351 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 S+ + L+R L + + R +I+NH W Sbjct: 352 SECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 384 >4UYA-A nrPDB Length = 340 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 61/256 (23%), Positives = 107/256 (41%), Gaps = 18/256 (7%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ-KVVKLKQIEHTLNEKRILQAV 99 ++ E + +G G FG+V + G A+K + + E E R+ + Sbjct: 25 FERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAML 82 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 P +++L +L +V+E+ GG + L R +A QI YLH Sbjct: 83 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL-AGRRIPPHVLVNWAVQIARGMLYLH 141 Query: 160 SLD---LIYRDLKPENLLIDQ--------QGYIQVTDFGFAKRVKGRTWTLC-GTPEYLA 207 +++RDLK N+L+ + +++TDFG A+ T G ++A Sbjct: 142 EEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWMA 201 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSHFSSD 265 PE+I S ++K D W+ GVL++E+ G P+ + + + K+ PS Sbjct: 202 PEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEP 261 Query: 266 LKDLLRNLLQVDLTKR 281 L++ Q D R Sbjct: 262 FAKLMKECWQQDPHIR 277 >6FEX-A nrPDB Length = 321 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 106/310 (34%), Gaps = 49/310 (15%) Query: 32 ENPAQNTAHLDQFERIKTLGTGSFGRVMLVK----------------HKETGNHFAMKIL 75 + P + + + LG G FG V L + K A+KIL Sbjct: 6 DGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL 65 Query: 76 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR 135 + L E +I+ + P +++L + L M+ +Y+ G++ L Sbjct: 66 RPDATKNARN--DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSA 123 Query: 136 IG-------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQ 182 S P AAQI YL +L+ ++RDL N L+ + I+ Sbjct: 124 HQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 183 Query: 183 VTDFGFAKRVKGRTWTLCGTP-----EYLAPEIILSKGYNKAVDWWALGVLIYE--MAAG 235 + DFG ++ + + ++A E IL + A D WA GV ++E M Sbjct: 184 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 243 Query: 236 YPPFFADQPIQIYEKI--------VSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGN--- 284 PF Q+ E + P L +L+ + +R Sbjct: 244 AQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 303 Query: 285 LKNGVNDIKN 294 + D N Sbjct: 304 HRFLAEDALN 313 >1UA2-A nrPDB Length = 346 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 122/294 (41%), Gaps = 41/294 (13%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ--IEHTLNEKRILQAV 99 ++E++ LG G F V + K T A+K + + K L E ++LQ + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYL 158 + P ++ L +F SN+ +V +++ ++ ++ + H + Y + EYL Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTL-CGTPEYLAPEIILS-K 214 H +++RDLKP NLL+D+ G +++ DFG AK R +T T Y APE++ + Sbjct: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS-----GKVRFPSHFS------ 263 Y VD WA+G ++ E+ P D + +I + ++P S Sbjct: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 Query: 264 -----------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 DL DL++ L + R K+F+ Sbjct: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSN 297 >3ORP-A nrPDB Length = 311 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 110/267 (41%), Gaps = 14/267 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D++E + LG G V L + A+K+L E + A+N Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 102 PFLVKLEYSFKDNSN----LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 P +V + + + + Y+VMEYV G + + G + A A + Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNF 131 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC------GTPEYLAPEII 211 H +I+RD+KP N++I ++V DFG A+ + ++ GT +YL+PE Sbjct: 132 SHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQA 191 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI-YEKIVSGKVRFP---SHFSSDLK 267 + D ++LG ++YE+ G PPF D P+ + Y+ + + S+DL Sbjct: 192 RGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLD 251 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKN 294 ++ L + R+ D+ Sbjct: 252 AVVLKALAKNPENRYQTAAEMRADLVR 278 >3E7O-A nrPDB Length = 360 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 68/343 (19%), Positives = 131/343 (38%), Gaps = 61/343 (17%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 L +++++K +G+G+ G V G + A+K L + + E +L+ VN Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSR-PFQNQTHAKRAYRELVLLKCVN 79 Query: 101 FPFLVKLEYSF------KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 ++ L F ++ ++Y+VME + + + + Q++ Sbjct: 80 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH--MELDHERMSYLLYQMLCG 136 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEIIL 212 ++LHS +I+RDLKP N+++ +++ DFG A+ T Y APE+IL Sbjct: 137 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVIL 196 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF---------- 262 GY + VD W++G ++ E+ G F I + K++ + F Sbjct: 197 GMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRN 256 Query: 263 --------------------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVN 290 +S +DLL +L +D KR V+ Sbjct: 257 YVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRI-----SVD 311 Query: 291 DIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333 + H + W + + P I + ++++E Sbjct: 312 EALRHPYITV--WYDPAEAEAPPPQIYDAQLEEREHAIEEWKE 352 >3BGP-A nrPDB Length = 333 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 73/278 (26%), Positives = 132/278 (47%), Gaps = 21/278 (7%) Query: 34 PAQNTAHLD-QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN- 91 P + L+ Q++ LG+G FG V A+K ++K ++ ++ + Sbjct: 47 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 106 Query: 92 --EKRILQAVNFPF--LVKLEYSFKDNSNLYMVMEYV-PGGEMFSHLRRIGRFSEPHARF 146 E +L+ V+ F +++L F+ + +++E P ++F + G E AR Sbjct: 107 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 166 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTWT-LCGTPE 204 + Q++ + H+ +++RD+K EN+LID +G +++ DFG +K +T GT Sbjct: 167 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 226 Query: 205 YLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS 263 Y PE I Y ++ W+LG+L+Y+M G PF D E+I+ G+V F S Sbjct: 227 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVS 280 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 S+ + L+R L + + R +I+NH W Sbjct: 281 SECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 313 >4YFF-A nrPDB Length = 311 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 119/305 (39%), Gaps = 15/305 (4%) Query: 2 GNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV 61 G+ + S +K + + L + P+ L + E + +G+GSFG+V Sbjct: 2 GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG 61 Query: 62 KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFK-DNSNLYMV 120 + + A+K ++ E IL +N P +++ + D S +V Sbjct: 62 RCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIV 119 Query: 121 MEYVPGGEMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLHS--LDLIYRDLKPENLLIDQ 177 +Y+ GG +FS L R A + EYLH+ +I+RDL N+L+ + Sbjct: 120 TQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYE 179 Query: 178 QGYIQVTDFGFAKRVK----GRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEM 232 G+ V DFG ++ ++ G ++APE+ Y D ++ + ++E+ Sbjct: 180 DGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEI 239 Query: 233 AAGYPPFFADQPIQIYEKIVSGKVRFPSHFS--SDLKDLLRNLLQVDLTKR--FGNLKNG 288 G PF +P + +R P +S + LL R F + Sbjct: 240 LTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMK 299 Query: 289 VNDIK 293 + + Sbjct: 300 LEECL 304 >4QNY-A nrPDB Length = 354 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 73/346 (21%), Positives = 143/346 (41%), Gaps = 28/346 (8%) Query: 32 ENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH-KETGNHFAMKILDKQKVVKLKQIEHTL 90 E A+ D++ + +G GS+G V+ + K AMK ++K+ ++ + L Sbjct: 10 ELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRIL 69 Query: 91 NEKRILQAVNFPFLVKLEYSF-----KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 145 E ++L N ++ L ++ + Y+VM+ + ++ LR +E H + Sbjct: 70 REIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQELTEAHIQ 128 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR---TWTLCGT 202 F+ Q + +HS +I+RD+ P N+L++ +++ DFG AK + Sbjct: 129 FFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTM 188 Query: 203 PEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH 261 Y APE+++ K Y+ +D W +G ++ E+ P F + +KIV Sbjct: 189 RWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEE 248 Query: 262 F-----SSDLKDLLRN---LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 313 SS + L+ Q D +R+ D+ H + + Sbjct: 249 DINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRH 308 Query: 314 PFIPKFKGPGDT------SNFDDYEEE---EIRVSINEKCGKEFSE 350 PF+ + D FD+ E++ +++ +I E+ K +E Sbjct: 309 PFLEQLHDDADDNLSYALFRFDENEQKTIVDVKRAIYEESVKFHNE 354 >6BSD-A nrPDB Length = 876 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 63/316 (19%), Positives = 106/316 (33%), Gaps = 55/316 (17%) Query: 32 ENPAQNTAHLDQFERIKTLGTGSFGRVMLVK----------------HKETGNHFAMKIL 75 + P + + + LG G FG V L + K A+KIL Sbjct: 561 DGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL 620 Query: 76 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR 135 + L E +I+ + P +++L + L M+ +Y+ G++ L Sbjct: 621 RPDATKNARN--DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSA 678 Query: 136 IG-------------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 S P AAQI YL +L+ ++RDL N L+ Sbjct: 679 HQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG 738 Query: 177 QQGYIQVTDFGFAKRVKGRTWTLCGTP-----EYLAPEIILSKGYNKAVDWWALGVLIYE 231 + I++ DFG ++ + + ++A E IL + A D WA GV ++E Sbjct: 739 ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWE 798 Query: 232 --MAAGYPPFFADQPIQIYEKI--------VSGKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 M PF Q+ E + P L +L+ + +R Sbjct: 799 VLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 858 Query: 282 FGN---LKNGVNDIKN 294 + D N Sbjct: 859 PPFSQLHRFLAEDALN 874 >1G3N-A nrPDB Length = 326 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 70/312 (22%), Positives = 128/312 (41%), Gaps = 47/312 (15%) Query: 43 QFERIKTLGTGSFGRVMLVKH-KETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN- 100 Q+E + +G G++G+V + K G A+K + Q + + T+ E +L+ + Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLS-TIREVAVLRHLET 70 Query: 101 --FPFLVKLEYSFK-----DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH--ARFYAAQI 151 P +V+L + L +V E+V ++ ++L ++ P + Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPE 209 + ++LHS +++RDLKP+N+L+ G I++ DFG A+ + ++ T Y APE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS-----GKVRFPSHFS- 263 ++L Y VD W++G + EM P F + KI+ G+ +P + Sbjct: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 Query: 264 --------------------SDL-KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 +L KDLL L + KR +H +F + Sbjct: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDLE 304 Query: 303 WIAIYQRKVEAP 314 P Sbjct: 305 RCKENLDSHLPP 316 >5AWM-A nrPDB Length = 394 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 66/336 (19%), Positives = 130/336 (38%), Gaps = 64/336 (19%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ ++ +G+G+ G V T + A+K L + + + E ++++ VN Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHK 103 Query: 103 FLVKLEYSF------KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 ++ L +F ++ ++Y+VME + + ++ + Q++ + Sbjct: 104 NIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQ--MDLDHDRMSYLLYQMLCGIK 160 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEIILSK 214 +LHS +I+RDLKP N+++ +++ DFG A+ T Y APE+IL Sbjct: 161 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM 220 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF------------ 262 GY + VD W++G ++ EM G F I + KI+ F Sbjct: 221 GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYV 280 Query: 263 -------------------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVND 291 +SD ++LL +L +D +R V++ Sbjct: 281 ENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SVDE 335 Query: 292 IKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN 327 H++ + +V+AP + D Sbjct: 336 ALKHEYIN----VWYDAEEVDAPAPEPYDHSVDERE 367 >3BBT-B nrPDB Length = 328 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 65/317 (20%), Positives = 130/317 (41%), Gaps = 22/317 (6%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHF----AMKILDKQKVVKLKQIEHTLNEKRILQA 98 + +R+K LG+G+FG V G A+KIL+ + K ++E I+ + Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN--ETTGPKANVEFMDEALIMAS 73 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEY 157 ++ P LV+L + + +V + +P G + ++ + QI Y Sbjct: 74 MDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMY 132 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCG---TPEYLAPEIIL 212 L L++RDL N+L+ ++++TDFG A+ ++G + + G +++A E I Sbjct: 133 LEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIH 192 Query: 213 SKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 + + D W+ GV I+E+ G P+ +I + + G ++ P + D+ ++ Sbjct: 193 YRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVM 252 Query: 271 RNLLQVDLTKRF------GNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGD 324 +D R D + + D + + ++ F D Sbjct: 253 VKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPN-DSKFFQNLLDEED 311 Query: 325 TSNFDDYEEEEIRVSIN 341 + D EE + + N Sbjct: 312 LEDMMDAEEYLVPQAFN 328 >3OZ6-A nrPDB Length = 388 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 77/370 (20%), Positives = 137/370 (37%), Gaps = 88/370 (23%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + L ++E +K LG G++G V + TG A+K + + T E Sbjct: 2 RVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIF-DAFQNSTDAQRTFREIM 60 Query: 95 ILQAVN-FPFLVKLEYSFK--DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151 IL ++ +V L + ++ ++Y+V +Y+ ++ + +R H ++ Q+ Sbjct: 61 ILTELSGHENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVIRANI-LEPVHKQYVVYQL 118 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV------------------- 192 + +YLHS L++RD+KP N+L++ + +++V DFG ++ Sbjct: 119 IKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTE 178 Query: 193 -----KGRTWTLCGTPEYLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 246 + T Y APEI+L Y K +D W+LG ++ E+ G P F + Sbjct: 179 NFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMN 238 Query: 247 IYEKIVSGKVRFPSH--------------------------------------------- 261 E+I+ G + FPS+ Sbjct: 239 QLERII-GVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINP 297 Query: 262 ---FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW---FATTDWIAIYQRKVEAPF 315 + + DLL LLQ + KR ND H + F + + P Sbjct: 298 KADCNEEALDLLDKLLQFNPNKRI-----SANDALKHPFVSIFHNPNEEPNCDHIITIPI 352 Query: 316 IPKFKGPGDT 325 K D Sbjct: 353 NDNVKHSIDD 362 >1V0B-A nrPDB Length = 288 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 127/296 (42%), Gaps = 42/296 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++++ ++ +G G++G V ++ G FA+K + +K T+ E IL+ + Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEK-EDEGIPSTTIREISILKELK 58 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLH 159 +VKL L +V E++ ++ L G A+ + Q++ Y H Sbjct: 59 HSNIVKLYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCH 117 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIILS-KG 215 +++RDLKP+NLLI+++G +++ DFG A+ + R +T T Y AP++++ K Sbjct: 118 DRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI--------------VSGKVRFPSH 261 Y+ +D W++G + EM G P F +I V+ ++ + Sbjct: 178 YSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPN 237 Query: 262 FS---------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 F+ DLL +L++D +R H +F + Sbjct: 238 FTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRI-----TAKQALEHAYFKENN 288 >3I81-A nrPDB Length = 315 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 121/303 (39%), Gaps = 27/303 (8%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHK-----ETGNHFAMKILDKQKVVKLKQIEH 88 P + ++ + LG GSFG V K E A+K ++ + +++ Sbjct: 10 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN--EAASMRERIE 67 Query: 89 TLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE------- 141 LNE +++ N +V+L ++ME + G++ S+LR + E Sbjct: 68 FLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAP 127 Query: 142 ---PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT 198 A +I YL++ ++RDL N ++ + +++ DFG + + + Sbjct: 128 PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYY 187 Query: 199 LCGTP-----EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIV 252 G +++PE + + D W+ GV+++E+A P+ Q+ ++ Sbjct: 188 RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVM 247 Query: 253 SGK-VRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFATTDWIAIYQR 309 G + P + L +L+R Q + R F + + + + F + + Sbjct: 248 EGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME-PGFREVSFYYSEEN 306 Query: 310 KVE 312 K+E Sbjct: 307 KME 309 >2WTK-C nrPDB Length = 305 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 85/306 (27%), Positives = 138/306 (45%), Gaps = 20/306 (6%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIE-HTLNEKRILQAV 99 + ++ LG GS+G+V V ET A+KIL K+K+ ++ E + E ++L+ + Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 100 NFPFLVKLEYSF--KDNSNLYMVMEYVPGG--EMFSHLRRIGRFSEPHARFYAAQIVLTF 155 +++L ++ +YMVMEY G EM + RF A Y Q++ Sbjct: 64 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPE-KRFPVCQAHGYFCQLIDGL 122 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-----GRTWTLCGTPEYLAPEI 210 EYLHS ++++D+KP NLL+ G ++++ G A+ + T G+P + PEI Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 211 ILSKG--YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 268 VD W+ GV +Y + G PF D +++E I G P L D Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 242 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 328 LL+ +L+ + KRF + I+ H WF + V P P K + Sbjct: 243 LLKGMLEYEPAKRF-----SIRQIRQHSWFRK--KHPPAEAPVPIPPSPDTKDRWRSMTV 295 Query: 329 DDYEEE 334 Y E+ Sbjct: 296 VPYLED 301 >2F9G-A nrPDB Length = 353 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 70/344 (20%), Positives = 140/344 (40%), Gaps = 39/344 (11%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 F+ LG G++G V HK TG A+K + + K TL E +IL+ Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHE 69 Query: 103 FLVKLE-----YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 ++ + SF++ + +Y++ E + ++ + S+ H +++ Q + + Sbjct: 70 NIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI-STQMLSDDHIQYFIYQTLRAVKV 127 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-------------KGRTWTLCGTPE 204 LH ++I+RDLKP NLLI+ ++V DFG A+ + + T Sbjct: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 Query: 205 YLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPFFA----DQPIQIYEKIVSGKVRFP 259 Y APE++L+ Y++A+D W+ G ++ E+ P F Q + I+ I + Sbjct: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Query: 260 SHF--SSDLKDLLRNLLQVDL---TKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAP 314 S ++ +++L K F + D+ + +E P Sbjct: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 Query: 315 FIPKFKGPGDTSN-------FDDYEEEEIRVSINEKCGKEFSEF 351 ++ + P D F +++ + ++ + ++E Sbjct: 308 YLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 >4ZSG-A nrPDB Length = 347 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 70/338 (20%), Positives = 142/338 (42%), Gaps = 30/338 (8%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D++E I+T+G G++G V + + TG A+K + V + + TL E +IL+ Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDV-VTNAKRTLRELKILKHFKH 65 Query: 102 PFLVKLEYSFK------DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 ++ ++ + + ++Y+V++ + ++ + + H R++ Q++ Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-------KGRTWTLCGTPEYLAP 208 +Y+HS +I+RDLKP NLL+++ +++ DFG A+ + + T Y AP Sbjct: 125 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 209 EIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF----- 262 E++LS Y +A+D W++G + EM A F + + I+ Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 244 Query: 263 SSDLKDLLRNLLQVDL---TKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKF 319 + ++ +++L + + + PF+ K+ Sbjct: 245 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 304 Query: 320 KGPGDTSN----FD-DYEEEE-IRVSINEKCGKEFSEF 351 P D + FD ++ E R I E E +F Sbjct: 305 HDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 342 >2BRG-A nrPDB Length = 297 Score = 223 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 75/272 (27%), Positives = 136/272 (50%), Gaps = 16/272 (5%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 ++ ++ ++TLG G++G V L ++ T A+KI+D ++ V E+ E I + Sbjct: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP--ENIKKEICINKM 61 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 +N +VK ++ + Y+ +EY GGE+F + EP A+ + Q++ YL Sbjct: 62 LNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL 121 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--RVKGRTWTL---CGTPEYLAPEIILS 213 H + + +RD+KPENLL+D++ ++++DFG A R R L CGT Y+APE++ Sbjct: 122 HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR 181 Query: 214 KGYN-KAVDWWALGVLIYEMAAGYPPF--FADQPIQIYEKIVSGKVRFP-SHFSSDLKDL 269 + ++ + VD W+ G+++ M AG P+ +D + + P S L Sbjct: 182 REFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLAL 241 Query: 270 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 L +L + + R + DIK +W+ Sbjct: 242 LHKILVENPSARI-----TIPDIKKDRWYNKP 268 >2XS0-A nrPDB Length = 386 Score = 223 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 69/366 (18%), Positives = 135/366 (36%), Gaps = 61/366 (16%) Query: 18 EFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK 77 +++ E L +++ +K +G+G+ G V + A+K L + Sbjct: 2 SMSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR 61 Query: 78 QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF------KDNSNLYMVMEYVPGGEMFS 131 + E +++ VN ++ L F ++ ++Y+VME + + Sbjct: 62 -PFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQ 119 Query: 132 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191 ++ + Q++ ++LHS +I+RDLKP N+++ +++ DFG A+ Sbjct: 120 VIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART 177 Query: 192 VKGRTWT--LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE 249 T Y APE+IL GY + VD W++G ++ EM G F I + Sbjct: 178 AGTSFMMVPFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWN 237 Query: 250 KIVSGKVRFPSHF------------------------------------------SSDLK 267 K++ F +S + Sbjct: 238 KVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQAR 297 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN 327 DLL +L +D +KR V++ H + W + + P IP + Sbjct: 298 DLLSKMLVIDASKRI-----SVDEALQHPYINV--WYDPSEAEAPPPKIPDKQLDEREHT 350 Query: 328 FDDYEE 333 ++++E Sbjct: 351 IEEWKE 356 >1JNK-A nrPDB Length = 423 Score = 223 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 130/352 (36%), Gaps = 61/352 (17%) Query: 32 ENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN 91 E L +++ +K +G+G+ G V + A+K L + + Sbjct: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYR 110 Query: 92 EKRILQAVNFPFLVKLEYSF------KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 145 E +++ VN ++ L F ++ ++Y+VME + + ++ Sbjct: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDHERMS 167 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR--TWTLCGTP 203 + Q++ ++LHS +I+RDLKP N+++ +++ DFG A+ T Sbjct: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--------- 254 Y APE+IL GY + VD W++G ++ EM F I + K++ Sbjct: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 Query: 255 ------------------KVRFPSHFSSD---------------LKDLLRNLLQVDLTKR 281 + FP F +DLL +L +D KR Sbjct: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 Query: 282 FGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333 V+D H + W + + P I + ++++E Sbjct: 348 I-----SVDDALQHPYINV--WYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 >4U41-A nrPDB Length = 332 Score = 223 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 62/279 (22%), Positives = 118/279 (42%), Gaps = 34/279 (12%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFP 102 FE ++ +G G++G+V +H +TG A+K++D V + E E +L+ + Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTEDEEEEIKLEINMLKKYSHHR 81 Query: 103 FLVKLEYSFKD------NSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARFYAAQIVLT 154 + +F + L++VME+ G + ++ + E + + +I+ Sbjct: 82 NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 141 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEII 211 +LH +I+RD+K +N+L+ + +++ DFG + ++ GR T GTP ++APE+I Sbjct: 142 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 201 Query: 212 L-----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF---- 262 Y+ D W+ G+ EMA G PP P++ I P Sbjct: 202 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN---PPPRLKSKK 258 Query: 263 -SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 S + L + +R + H + Sbjct: 259 WSKKFFSFIEGCLVKNYMQR-----PSTEQLLKHPFIRD 292 >4XI2-A nrPDB Length = 446 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 115/248 (46%), Gaps = 14/248 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNH-FAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +K LGTG FG V K + G + A+K++ + + + + + E +++ ++ Sbjct: 187 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSE----DEFIEEAKVMMNLS 240 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLH 159 LV+L ++++ EY+ G + ++LR RF + EYL Sbjct: 241 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 300 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-LCGTP---EYLAPEIILSKG 215 S ++RDL N L++ QG ++V+DFG ++ V +T G+ + PE+++ Sbjct: 301 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 360 Query: 216 YNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGKVRFPSHFSSD-LKDLLRNL 273 ++ D WA GVL++E+ + G P+ + E I G + H +S+ + ++ + Sbjct: 361 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSC 420 Query: 274 LQVDLTKR 281 +R Sbjct: 421 WHEKADER 428 >5NGU-A nrPDB Length = 381 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 66/335 (19%), Positives = 135/335 (40%), Gaps = 30/335 (8%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ + +G G++G V A+K + + TL E +IL Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS--PFEHQTYCQRTLREIKILLRFRHE 100 Query: 103 FLVKLEYSF-----KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 ++ + + ++Y+V + + +++ L + S H ++ QI+ +Y Sbjct: 101 NIIGINDIIRAPTIEQMKDVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKY 158 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT------WTLCGTPEYLAPEI- 210 +HS ++++RDLKP NLL++ +++ DFG A+ T Y APEI Sbjct: 159 IHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH-----FSSD 265 + SKGY K++D W++G ++ EM + P F + I+ + Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 266 LKDLLRNLLQVD--LTKR-FGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP 322 ++ L +L + R F N + D+ + ++ + P++ ++ P Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 338 Query: 323 GDTS------NFDDYEEEEIRVSINEKCGKEFSEF 351 D FD ++ + + E +E + F Sbjct: 339 SDEPIAEAPFKFDMELDDLPKEKLKELIFEETARF 373 >6E4F-A nrPDB Length = 290 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 60/248 (24%), Positives = 115/248 (46%), Gaps = 14/248 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNH-FAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +K LGTG FG V K + G + A+K++ + + + + IE E +++ ++ Sbjct: 31 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEFIE----EAKVMMNLS 84 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLH 159 LV+L ++++ EY+ G + ++LR RF + EYL Sbjct: 85 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 144 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-LCGTP---EYLAPEIILSKG 215 S ++RDL N L++ QG ++V+DFG ++ V +T G+ + PE+++ Sbjct: 145 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 204 Query: 216 YNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNL 273 ++ D WA GVL++E+ + G P+ + E I G ++ P S + ++ + Sbjct: 205 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 264 Query: 274 LQVDLTKR 281 +R Sbjct: 265 WHEKADER 272 >5U6B-A nrPDB Length = 307 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 116/272 (42%), Gaps = 24/272 (8%) Query: 46 RIKTLGTGSFGRVMLVKHKETG--NHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 KTLG G FG VM + + A+K + K + ++E L+E ++ + P Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTM-KIAICTRSELEDFLSEAVCMKEFDHPN 85 Query: 104 LVKLEYSFKDNSNL------YMVMEYVPGGEMFSHL------RRIGRFSEPHARFYAAQI 151 +++L S +++ ++ G++ S L + + A I Sbjct: 86 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145 Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG-----TPEYL 206 EYL + I+RDL N ++++ + V DFG +K++ + G +++ Sbjct: 146 ASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI 205 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSS 264 A E + + Y D W+ GV ++E+A G P+ + +IY+ + G +++ P+ Sbjct: 206 AIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLD 265 Query: 265 DLKDLLRNLLQVDLTKR--FGNLKNGVNDIKN 294 L L+ +++ R F L+ + + Sbjct: 266 GLYALMSRCWELNPQDRPSFTELREDLENTLK 297 >4Y93-A nrPDB Length = 446 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 115/248 (46%), Gaps = 14/248 (5%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNH-FAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +K LGTG FG V K + G + A+K++ + + + + + E +++ ++ Sbjct: 188 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSE----DEFIEEAKVMMNLS 241 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLH 159 LV+L ++++ EY+ G + ++LR RF + EYL Sbjct: 242 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 301 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-LCGTP---EYLAPEIILSKG 215 S ++RDL N L++ QG ++V+DFG + V +T G+ ++ +PE+++ Sbjct: 302 SKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSK 361 Query: 216 YNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNL 273 ++ D WA GVL++E+ + G P+ + E I G ++ P S + ++ + Sbjct: 362 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYSC 421 Query: 274 LQVDLTKR 281 +R Sbjct: 422 WHEKADER 429 >4NST-A nrPDB Length = 351 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 74/332 (22%), Positives = 132/332 (39%), Gaps = 58/332 (17%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 +D+F+ I +G G++G+V K K+TG A+K + K + E +I Sbjct: 7 WGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDN-EKEGFPITAIREIKI 65 Query: 96 LQAVNFPFLVKLEYSFKDNSN----------LYMVMEYVPGGEMFSHLRRI-GRFSEPHA 144 L+ + +V ++ D + Y+V EY+ ++ L FSE H Sbjct: 66 LRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHI 124 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT----WTLC 200 + + Q++ EY H + ++RD+K N+L++ G I++ DFG A+ Sbjct: 125 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 184 Query: 201 GTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI-------- 251 T Y PE++L + Y A+D W+ G ++ E+ P F A+ + E I Sbjct: 185 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 244 Query: 252 -------------------VSGKVRFPSHFS---SDLKDLLRNLLQVDLTKRFGNLKNGV 289 + R FS S DLL ++L +D +KR + Sbjct: 245 PAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQ 304 Query: 290 NDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG 321 +D + K+ P +P ++ Sbjct: 305 SDFLK----------DVELSKMAPPDLPHWQD 326 >4RC3-A nrPDB Length = 289 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 71/268 (26%), Positives = 128/268 (47%), Gaps = 20/268 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN---EKRILQAV 99 Q++ LG+G FG V A+K ++K ++ ++ + E +L+ V Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 100 NFPF--LVKLEYSFKDNSNLYMVMEYV-PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + F +++L F+ + +++E P ++F + G E AR + Q++ Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 132 Query: 157 YLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTWT-LCGTPEYLAPEIILSK 214 + H+ +++RD+K EN+LID +G +++ DFG +K +T GT Y PE I Sbjct: 133 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 192 Query: 215 GY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 Y ++ W+LG+L+Y+M G PF D E+I+ G+V F SS+ + L+R Sbjct: 193 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 246 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFATT 301 L + + R +I+NH W Sbjct: 247 LALRPSDR-----PTFEEIQNHPWMQDV 269 >1U59-A nrPDB Length = 287 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 53/244 (21%), Positives = 106/244 (43%), Gaps = 14/244 (5%) Query: 49 TLGTGSFGRVMLVKHKETGNH--FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 LG G+FG V ++ A+K+L + + E + E +I+ ++ P++V+ Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK--QGTEKADTEEMMREAQIMHQLDNPYIVR 74 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 L + + L +VME GG + L + + Q+ + +YL + ++ Sbjct: 75 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG------TPEYLAPEIILSKGYNKA 219 RDL N+L+ + Y +++DFG +K + ++ APE I + ++ Sbjct: 134 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 193 Query: 220 VDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGK-VRFPSHFSSDLKDLLRNLLQVD 277 D W+ GV ++E ++ G P+ + ++ I GK + P +L L+ + Sbjct: 194 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 253 Query: 278 LTKR 281 R Sbjct: 254 WEDR 257 >3ZBF-A nrPDB Length = 322 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 112/270 (41%), Gaps = 27/270 (10%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKE-----TGN-HFAMKILDKQKVVKLKQIEHTLNEKRI 95 ++ LG+G+FG V + +G A+K L K + K L E + Sbjct: 33 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI--EFLKEAHL 90 Query: 96 LQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-------RFSEPHARFYA 148 + N P ++K N Y+++E + GG++ ++LR+ + Sbjct: 91 MSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLC 150 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-----IQVTDFGFAKRV-KGRTWTLCG- 201 I YL + I+RDL N L+ + Y +++ DFG A+ + K + G Sbjct: 151 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGE 210 Query: 202 ---TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKI-VSGKV 256 ++APE ++ + D W+ G+LI+E+ G+ P+ A + + + G++ Sbjct: 211 GLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRL 270 Query: 257 RFPSHFSSDLKDLLRNLLQVDLTKRFGNLK 286 P + DL +L+ + +R + Sbjct: 271 EPPRNCPDDLWNLMTQCWAQEPDQRPTFHR 300 >6DBM-A nrPDB Length = 318 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 119/282 (42%), Gaps = 32/282 (11%) Query: 31 WENPAQNTAHLDQF-ERIKTLGTGSFGRVMLV----KHKETGNHFAMKILDKQKVVKLKQ 85 ++ P T ++ ++I+ LG G FG+V L + TG A+K L + Sbjct: 19 FQGPGDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAG--PQH 76 Query: 86 IEHTLNEKRILQAVNFPFLVKLEYSFKDNS--NLYMVMEYVPGGEMFSHLRRIGRFSEPH 143 E IL+ + ++K + +D +L +VMEYVP G + +L R Sbjct: 77 RSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRH-SIGLAQ 135 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLC-- 200 +A QI YLHS I+RDL N+L+D +++ DFG AK V +G + Sbjct: 136 LLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRE 195 Query: 201 ---GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGY-----PPFF----------AD 242 + APE + + A D W+ GV +YE+ PP Sbjct: 196 DGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQM 255 Query: 243 QPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFG 283 +++ E + G ++ P +++ L++N + + + R Sbjct: 256 TVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPT 297 >5EFQ-A nrPDB Length = 347 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 67/335 (20%), Positives = 131/335 (39%), Gaps = 58/335 (17%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 + +D+F+ I +G G++G+V + K+TG A+K + K + E Sbjct: 2 DIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDN-EKEGFPITAIRE 60 Query: 93 KRILQAVNFPFLVKLEYSFKDNSN----------LYMVMEYVPGGEMFSHLRRI-GRFSE 141 +IL+ + ++ ++ D + Y+V EY+ ++ L F+E Sbjct: 61 IKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNE 119 Query: 142 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT----W 197 H + + Q++ +Y H + ++RD+K N+L++ +G I++ DFG A+ Sbjct: 120 NHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYT 179 Query: 198 TLCGTPEYLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS-GK 255 T Y PE++L + Y A+D W+ G ++ E+ P F A+Q + E I Sbjct: 180 NKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICG 239 Query: 256 VRFPSHFSSDLK-----------------------------DLLRNLLQVDLTKRFGNLK 286 P+ + +K DL +L +D +KR Sbjct: 240 SPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRC---- 295 Query: 287 NGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG 321 ++ K+ P +P ++ Sbjct: 296 -TAEQALQCEFLRDV-----EPSKMPPPDLPLWQD 324 >2OZO-A nrPDB Length = 613 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 52/244 (21%), Positives = 106/244 (43%), Gaps = 14/244 (5%) Query: 49 TLGTGSFGRVMLVKHKETGNH--FAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 LG G+FG V ++ A+K+L + + E + E +I+ ++ P++V+ Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK--QGTEKADTEEMMREAQIMHQLDNPYIVR 400 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIY 165 L + + L +VME GG + L + + Q+ + +YL + ++ Sbjct: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 Query: 166 RDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG------TPEYLAPEIILSKGYNKA 219 R+L N+L+ + Y +++DFG +K + ++ APE I + ++ Sbjct: 460 RNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 Query: 220 VDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGK-VRFPSHFSSDLKDLLRNLLQVD 277 D W+ GV ++E ++ G P+ + ++ I GK + P +L L+ + Sbjct: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 579 Query: 278 LTKR 281 R Sbjct: 580 WEDR 583 >6DTL-A nrPDB Length = 364 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 123/307 (40%), Gaps = 46/307 (14%) Query: 47 IKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 106 I +G G++G V + ET A+K + K+ + TL E ++L+ ++ +V Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI-DAKRTLREIKLLRHMDHENIVA 93 Query: 107 LEYSFKDN-----SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 + +++Y+ E + ++ +R SE H +++ QI+ +Y+HS Sbjct: 94 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 152 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEIILS-KGYNK 218 ++++RDLKP NLL++ +++ DFG A+ T Y APE++L+ Y Sbjct: 153 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 212 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS-----------------GKV--RFP 259 A+D W++G + E+ P F + ++ + + P Sbjct: 213 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 272 Query: 260 SH-----------FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ 308 + DL+ +L D +R L D H + + + Sbjct: 273 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL-----DALAHPYLNSLH-DISDE 326 Query: 309 RKVEAPF 315 + PF Sbjct: 327 PECTIPF 333 >5O2B-A nrPDB Length = 285 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 68/264 (25%), Positives = 128/264 (48%), Gaps = 18/264 (6%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 LG G+F V ET A L +K+ K +Q + E +L+ + P +V+ Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHPNIVRFY 81 Query: 109 YSFKD----NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD-- 162 S++ + +V E + G + ++L+R R + QI+ ++LH+ Sbjct: 82 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 163 LIYRDLKPENLLID-QQGYIQVTDFGFAKRVK-GRTWTLCGTPEYLAPEIILSKGYNKAV 220 +I+RDLK +N+ I G +++ D G A ++ ++ GTPE++APE+ + Y+++V Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMY-EEHYDESV 200 Query: 221 DWWALGVLIYEMAAGYPPF-FADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVD 277 D +A G+ + EMA P+ QIY K+ SG F ++K+++ ++ + Sbjct: 201 DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQN 260 Query: 278 LTKRFGNLKNGVNDIKNHKWFATT 301 ++R + D+ NH +FA Sbjct: 261 KSERL-----SIRDLLNHAFFAED 279 >3GC0-A nrPDB Length = 329 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 125/310 (40%), Gaps = 46/310 (14%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 A + +D++ RI LG G++G V T A+K + + + + E Sbjct: 27 APSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEH-EEEGVPGTAIREVS 85 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 +L+ + +++L+ N L+++ EY ++ ++ + S + + Q++ Sbjct: 86 LLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLING 144 Query: 155 FEYLHSLDLIYRDLKPENLLI-----DQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYL 206 + HS ++RDLKP+NLL+ + +++ DFG A+ + R +T T Y Sbjct: 145 VNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYR 204 Query: 207 APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG----------- 254 PEI+L + Y+ +VD W++ + EM P F D I KI Sbjct: 205 PPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPG 264 Query: 255 -------KVRFPSHFSSDLKDLL------------RNLLQVDLTKRFGNLKNGVNDIKNH 295 K FP LK +L +L++D KR + H Sbjct: 265 VTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRI-----SAKNALEH 319 Query: 296 KWFATTDWIA 305 +F+ D+ Sbjct: 320 PYFSHNDFDP 329 >4OLI-A nrPDB Length = 645 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 69/280 (24%), Positives = 117/280 (41%), Gaps = 33/280 (11%) Query: 32 ENPAQNTA--HLDQFERIKTLGTGSFGRVMLV----KHKETGNHFAMKILDKQKVVKLKQ 85 ++PA + H ++I+ LG G FG+V L + TG A+K L + Sbjct: 341 DSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD--CGPQH 398 Query: 86 IEHTLNEKRILQAVNFPFLVKLEYSFKDNSN--LYMVMEYVPGGEMFSHLRRIGRFSEPH 143 E IL+ + ++K + +D L +VMEYVP G + +L R Sbjct: 399 RSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH-SIGLAQ 457 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLC-- 200 +A QI YLHS I+R+L N+L+D +++ DFG AK V +G + Sbjct: 458 LLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRE 517 Query: 201 ---GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGY-----PPFF----------AD 242 + APE + + A D W+ GV +YE+ PP Sbjct: 518 DGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQM 577 Query: 243 QPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 +++ E + G ++ P ++ L++N + + + R Sbjct: 578 TVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFR 617 Score = 133 bits (336), Expect = 8e-32, Method: Composition-based stats. Identities = 51/244 (20%), Positives = 90/244 (36%), Gaps = 19/244 (7%) Query: 61 VKHKETGNHFAMKILDKQKVVKLKQIEHTLNE-KRILQAVNFPFLVKLEYSFKDNSNLYM 119 + + +K+LD I E ++ V+ L + M Sbjct: 88 GRDRGQELRVVLKVLDPSH----HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIM 143 Query: 120 VMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ 178 V EYV G + LRR G A Q+ YL + +L++ ++ N+L+ + Sbjct: 144 VTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 203 Query: 179 G-------YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK--GYNKAVDWWALGVLI 229 G +I+++D G R + P +LAPE + + A+D W G + Sbjct: 204 GLAEGTSPFIKLSDPGVGLGALSREERVERIP-WLAPECLPGGANSLSTAMDKWGFGATL 262 Query: 230 YEMAA-GYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNG 288 E+ G P + P + E + R P L L L + T+R + + Sbjct: 263 LEICFDGEAPLQSRSPSEK-EHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR-PSFRTI 320 Query: 289 VNDI 292 + D+ Sbjct: 321 LRDL 324 >5O2C-A nrPDB Length = 380 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 73/313 (23%), Positives = 138/313 (44%), Gaps = 29/313 (9%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 LG G+F V ET A L +K+ K +Q + E +L+ + P +V+ Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHPNIVRFY 90 Query: 109 YSFKD----NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD-- 162 S++ + +V E + G + ++L+R R + QI+ ++LH+ Sbjct: 91 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 163 LIYRDLKPENLLID-QQGYIQVTDFGFAKRVK-GRTWTLCGTPEYLAPEIILSKGYNKAV 220 +I+RDLK +N+ I G +++ D G A ++ ++ GTPE++APE+ + Y+++V Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMY-EEHYDESV 209 Query: 221 DWWALGVLIYEMAAGYPPF-FADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVD 277 D +A G+ + EMA P+ QIY K+ SG F ++K+++ ++ + Sbjct: 210 DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQN 269 Query: 278 LTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIR 337 ++R + D+ NH +FA + + D SN + Sbjct: 270 KSERL-----SIRDLLNHAFFAE-----------DTGLRVELAEEDDCSNSSLALRLWVE 313 Query: 338 VSINEKCGKEFSE 350 K + +E Sbjct: 314 DPKKLKGKHKDNE 326 >3PP0-A nrPDB Length = 338 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 131/305 (42%), Gaps = 23/305 (7%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHF----AMKILDKQKVVKLKQIEHTLNEKRILQA 98 + ++K LG+G+FG V G + A+K+L ++ K + L+E ++ Sbjct: 18 ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVL--RENTSPKANKEILDEAYVMAG 75 Query: 99 VNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEY 157 V P++ +L ++ + +V + +P G + H+R GR + QI Y Sbjct: 76 VGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSY 134 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK--RVKGRTWTLCG---TPEYLAPEIIL 212 L + L++RDL N+L+ ++++TDFG A+ + + G +++A E IL Sbjct: 135 LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL 194 Query: 213 SKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 270 + + D W+ GV ++E+ G P+ +I + + G ++ P + D+ ++ Sbjct: 195 RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIM 254 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 330 +D R + V++ + Q + P P D++ + Sbjct: 255 VKCWMIDSECR-PRFRELVSEFSRMA--RDPQRFVVIQNEDLGP-----ASPLDSTFYRS 306 Query: 331 YEEEE 335 E++ Sbjct: 307 LLEDD 311 >3LZB-A nrPDB Length = 327 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 120/265 (45%), Gaps = 18/265 (6%) Query: 32 ENPAQNTAHL---DQFERIKTLGTGSFGRVMLVKHKETGNHF----AMKILDKQKVVKLK 84 E P Q + +F++IK LG+G+FG V G A+K L ++ K Sbjct: 2 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL--REATSPK 59 Query: 85 QIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPH 143 + L+E ++ +V+ P + +L ++ + ++ + +P G + ++R + Sbjct: 60 ANKEILDEAYVMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQY 118 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCG 201 + QI YL L++RDL N+L+ ++++TDFG AK + + + + G Sbjct: 119 LLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG 178 Query: 202 ---TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KV 256 +++A E IL + Y D W+ GV ++E+ G P+ +I + G ++ Sbjct: 179 GKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERL 238 Query: 257 RFPSHFSSDLKDLLRNLLQVDLTKR 281 P + D+ ++R +D R Sbjct: 239 PQPPICTIDVYMIMRKCWMIDADSR 263 >5G6V-A nrPDB Length = 324 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 118/296 (39%), Gaps = 43/296 (14%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 ++ + ++ LG G++ V K K T N A+K + + + E +L+ + Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCT--AIREVSLLKDLK 58 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRF-SEPHARFYAAQIVLTFEYLH 159 +V L +L +V EY+ ++ +L G + + + + Q++ Y H Sbjct: 59 HANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 117 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIILSK-G 215 +++RDLKP+NLLI+++G +++ DFG A+ T T T Y P+I+L Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTD 177 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS-------------------GKV 256 Y+ +D W +G + YEMA G P F + I Sbjct: 178 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 237 Query: 257 RFP-----------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 +P SD DLL LLQ + R D H +F + Sbjct: 238 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRI-----SAEDAMKHPFFLSL 288 >3DLS-A nrPDB Length = 335 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 76/284 (26%), Positives = 129/284 (45%), Gaps = 26/284 (9%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH-----TLNEKR 94 + ++ + LG+G+FG V KE +K + K+KV++ IE E Sbjct: 22 YSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIA 81 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVME-YVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 IL V ++K+ F++ +VME + G ++F+ + R R EP A + Q+V Sbjct: 82 ILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVS 141 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEII 211 YL D+I+RD+K EN++I + I++ DFG A ++ +T CGT EY APE++ Sbjct: 142 AVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVL 201 Query: 212 LSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 270 + Y ++ W+LGV +Y + PF E+ V + P S +L L+ Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPFCE------LEETVEAAIHPPYLVSKELMSLV 255 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWFA------TTDWIAIYQ 308 LLQ +R + + W W +++ Sbjct: 256 SGLLQPVPERR-----TTLEKLVTDPWVTQPVNLADYTWEEVFR 294 >4QTB-A nrPDB Length = 380 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 72/338 (21%), Positives = 142/338 (42%), Gaps = 36/338 (10%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ +++ +G G++G V A+K + + TL E +IL Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHE 99 Query: 103 FLVKLEYSF-----KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 ++ + + ++Y+V + + +++ L+ + S H ++ QI+ +Y Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKS-QQLSNDHICYFLYQILRGLKY 157 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT------WTLCGTPEYLAPEI- 210 +HS ++++RDLKP NLLI+ +++ DFG A+ T Y APEI Sbjct: 158 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 270 + SKGY K++D W++G ++ EM + P F + I+ G + PS DL ++ Sbjct: 218 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GILGSPSQ--EDLNCII 274 Query: 271 ----RNLLQVDLT-------KRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKF 319 RN LQ + K F + D+ + + + + P++ ++ Sbjct: 275 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 334 Query: 320 KGPGDTS------NFDDYEEEEIRVSINEKCGKEFSEF 351 P D F ++ + + E +E + F Sbjct: 335 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARF 372 >3PLS-A nrPDB Length = 298 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 114/261 (43%), Gaps = 18/261 (6%) Query: 48 KTLGTGSFGRVMLVKHKE---TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFL 104 + +G G FG V ++ + A+K L + + +++Q+E L E +++ +N P + Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR--ITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 105 VKLEYSFKDNSNL-YMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLHSLD 162 + L L ++++ Y+ G++ +R R + + Q+ EYL Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG-------TPEYLAPEIILSKG 215 ++RDL N ++D+ ++V DFG A+ + R + ++ A E + + Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 216 YNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNL 273 + D W+ GVL++E+ G PP+ P + + G ++ P + L +++ Sbjct: 205 FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQC 264 Query: 274 LQVDLTKR--FGNLKNGVNDI 292 + D R F L V I Sbjct: 265 WEADPAVRPTFRVLVGEVEQI 285 >3FI2-A nrPDB Length = 353 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 65/318 (20%), Positives = 119/318 (37%), Gaps = 59/318 (18%) Query: 32 ENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN 91 E L +++ +K +G+G+ G V + A+K L + + Sbjct: 14 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYR 72 Query: 92 EKRILQAVNFPFLVKLEYSF------KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 145 E +++ VN ++ L F ++ ++Y+VME + + ++ Sbjct: 73 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDHERMS 129 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR--TWTLCGTP 203 + Q++ ++LHS +I+RDLKP N+++ +++ DFG A+ T Sbjct: 130 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 189 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--------- 254 Y APE+IL GY + VD W++G ++ EM F I + K++ Sbjct: 190 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 249 Query: 255 ------------------KVRFPSHFSSD---------------LKDLLRNLLQVDLTKR 281 + FP F +DLL +L +D KR Sbjct: 250 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 309 Query: 282 FGNLKNGVNDIKNHKWFA 299 V+D H + Sbjct: 310 I-----SVDDALQHPYIN 322 >5GNK-A nrPDB Length = 297 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 120/265 (45%), Gaps = 18/265 (6%) Query: 32 ENPAQNTAHL---DQFERIKTLGTGSFGRVMLVKHKETGNHF----AMKILDKQKVVKLK 84 E P Q + +F++IK LG+G+FG V G A+K L ++ K Sbjct: 6 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL--REATSPK 63 Query: 85 QIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPH 143 + L+E ++ +V+ P + +L ++ + ++M+ +P G + ++R + Sbjct: 64 ANKEILDEAYVMASVDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQY 122 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCG 201 + QI YL L++RDL N+L+ ++++TDFG AK + + + + G Sbjct: 123 LLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG 182 Query: 202 ---TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KV 256 +++A E IL + Y D W+ GV ++E+ G P+ +I + G ++ Sbjct: 183 GKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERL 242 Query: 257 RFPSHFSSDLKDLLRNLLQVDLTKR 281 P + D+ ++ +D R Sbjct: 243 PQPPICTIDVYMIMVKCWMIDADSR 267 >4EQM-A nrPDB Length = 294 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 119/260 (45%), Gaps = 9/260 (3%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++++ + LG G V L + A+K + K + ++ E ++ Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 +V + +++ Y+VMEY+ G + ++ G S A + QI+ ++ H + Sbjct: 71 QNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDM 130 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC----GTPEYLAPEIILSKGYN 217 +++RD+KP+N+LID +++ DFG AK + + T GT +Y +PE + + Sbjct: 131 RIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATD 190 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV-----RFPSHFSSDLKDLLRN 272 + D +++G+++YEM G PPF + + I K + V L +++ Sbjct: 191 ECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSLSNVILR 250 Query: 273 LLQVDLTKRFGNLKNGVNDI 292 + D R+ ++ +D+ Sbjct: 251 ATEKDKANRYKTIQEMKDDL 270 >5Z33-A nrPDB Length = 425 Score = 217 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 76/343 (22%), Positives = 131/343 (38%), Gaps = 60/343 (17%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN- 100 +++ K LG G++G V + +T A+K + K + L E ++LQ Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTN-VFSKKILAKRALREIKLLQHFRG 89 Query: 101 FPFLVKLEYS-FKDNSNL---YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 + L N Y+ E + ++ + +R ++ H + + QI+ + Sbjct: 90 HRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAHFQSFIYQILCGLK 148 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-------GRTWTLCGTPEYLAPE 209 Y+HS ++++RDLKP NLL++ +++ DFG A+ G T Y APE Sbjct: 149 YIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPE 208 Query: 210 IILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV---------------- 252 I+LS + Y KA+D W++G ++ E+ G P F + +I+ Sbjct: 209 IMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGS 268 Query: 253 ------------SGKVRFPSHFS---SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHK- 296 K FP+ F D DLL +L D + R V H Sbjct: 269 PRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRI-----SVEQALEHPY 323 Query: 297 ---WFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 336 W +D + F F+ D +E+ Sbjct: 324 LHIWHDASD-----EPDCPTTFNFDFEVVEDVGEMRKMILDEV 361 >5HLW-A nrPDB Length = 299 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 50/262 (19%), Positives = 112/262 (42%), Gaps = 21/262 (8%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVK---HKETGNHFAMKILDKQKVVKLKQIEHTL 90 P+ H + + +G G FG V + H A+K L++ + + ++ L Sbjct: 17 PSSLIVHFN-----EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFL 69 Query: 91 NEKRILQAVNFPFLVKLEYSF-KDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYA 148 E I++ + P ++ L + + +V+ Y+ G++ + +R + + Sbjct: 70 TEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFG 129 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----- 203 Q+ +YL S ++RDL N ++D++ ++V DFG A+ + + + Sbjct: 130 LQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKL 189 Query: 204 --EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFP 259 +++A E + ++ + D W+ GVL++E+ G PP+ I ++ G ++ P Sbjct: 190 PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQP 249 Query: 260 SHFSSDLKDLLRNLLQVDLTKR 281 + L +++ R Sbjct: 250 EYCPDPLYEVMLKCWHPKAEMR 271 >6DBN-A nrPDB Length = 316 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 129/320 (40%), Gaps = 39/320 (12%) Query: 10 GSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQ--FERIKTLGTGSFGRVMLVKHKE-- 65 GS + + + + +K + H ++ +RI+ LG G FG+V L ++ Sbjct: 1 GSIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEG 60 Query: 66 --TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSN--LYMVM 121 TG A+K L + I E IL+ + +VK + ++ + ++M Sbjct: 61 DNTGEQVAVKSLKPESGG--NHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIM 118 Query: 122 EYVPGGEMFSHL-RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 E++P G + +L + + + YA QI +YL S ++RDL N+L++ + Sbjct: 119 EFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ 178 Query: 181 IQVTDFGFAKRVKGRTWTLCG------TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA 234 +++ DFG K ++ + APE ++ + A D W+ GV ++E+ Sbjct: 179 VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT 238 Query: 235 GYPPFFADQPIQIYEKIV------------------SGKVRFPSHFSSDLKDLLRNLLQV 276 P+ ++ K++ ++ P + ++ L+R + Sbjct: 239 YCD--SDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEF 296 Query: 277 DLTKR--FGNLKNGVNDIKN 294 + R F NL G + Sbjct: 297 QPSNRTSFQNLIEGFEALLK 316 >5HI2-A nrPDB Length = 283 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 68/305 (22%), Positives = 121/305 (39%), Gaps = 46/305 (15%) Query: 5 AAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHK 64 GS D WE P Q + +G+GSFG V K Sbjct: 2 HHHHHGS-------------RDSSDDWEIPD------GQITVGQRIGSGSFGTVYKGKWH 42 Query: 65 ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYV 124 A+K+L +Q++ NE +L+ ++ L + L +V ++ Sbjct: 43 GD---VAVKML------TPQQLQAFKNEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWC 92 Query: 125 PGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 183 G ++ HL +F A Q +YLH+ +I+RDLK N+ + + +++ Sbjct: 93 EGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKI 152 Query: 184 TDFGFA----KRVKGRTWT-LCGTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEMAAG 235 DFG A + + L G+ ++APE+I S Y+ D +A G+++YE+ G Sbjct: 153 GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTG 212 Query: 236 YPPFFADQPI-QIYEKIVSGKVRFP-----SHFSSDLKDLLRNLLQVDLTKR--FGNLKN 287 P+ QI E + G + S+ +K L+ L+ +R F + Sbjct: 213 QLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILA 272 Query: 288 GVNDI 292 + ++ Sbjct: 273 EIEEL 277 >4PWN-A nrPDB Length = 274 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 67/266 (25%), Positives = 127/266 (47%), Gaps = 23/266 (8%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 +G GSF V ET A L +K+ K + + E +L+ + P +V+ Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTK-SERQRFKEEAEMLKGLQHPNIVRFY 75 Query: 109 YSFKD----NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD-- 162 S++ + +V E + G + ++L+R R + QI+ ++LH+ Sbjct: 76 DSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 163 LIYRDLKPENLLID-QQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGYNKA 219 +I+RDLK +N+ I G +++ D G A K ++ GTPE++APE+ + Y+++ Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY-EEKYDES 194 Query: 220 VDWWALGVLIYEMAAGYPPF-FADQPIQIYEKIVSGKVRFPSHFS----SDLKDLLRNLL 274 VD +A G+ + EMA P+ QIY ++ SG P+ F ++K+++ + Sbjct: 195 VDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSG--VKPASFDKVAIPEVKEIIEGCI 252 Query: 275 QVDLTKRFGNLKNGVNDIKNHKWFAT 300 + + +R+ + D+ NH +F Sbjct: 253 RQNKDERY-----SIKDLLNHAFFQE 273 >5U6C-A nrPDB Length = 315 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 124/296 (41%), Gaps = 27/296 (9%) Query: 22 KAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKE---TGNHFAMKILDKQ 78 + E+ K E+ + L K LG G FG VM K+ T A+K + Sbjct: 19 QGSEELQNKLEDVVIDRNLL---ILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLD 75 Query: 79 KVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDN-----SNLYMVMEYVPGGEMFSHL 133 ++IE L+E ++ + P +++L + +++ ++ G++ ++L Sbjct: 76 N-SSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYL 134 Query: 134 RRI------GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFG 187 + I L EYL + + ++RDL N ++ + V DFG Sbjct: 135 LYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFG 194 Query: 188 FAKRVKGRTWTLCG-----TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFA 241 +K++ + G +++A E + + Y D WA GV ++E+A G P+ Sbjct: 195 LSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 254 Query: 242 DQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKN 294 Q ++Y+ ++ G +++ P +L +++ + + D R F L+ + + Sbjct: 255 VQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 310 >3M42-A nrPDB Length = 299 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 86/313 (27%), Positives = 147/313 (46%), Gaps = 57/313 (18%) Query: 41 LDQFERI-KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL-QA 98 +D ++ + LG G G+V+ + +K T FA+K+L + E + +A Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 67 Query: 99 VNFPFLVKLEYSFKD----NSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIV 152 P +V++ +++ L +VME + GGE+FS ++ G F+E A I Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQ---QGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPE 209 +YLHS+++ +RD+KPENLL +++TDFGFAK G Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTG--------------- 172 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI----YEKIVSGKVRFP----SH 261 + Y+K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP S Sbjct: 173 ----EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 228 Query: 262 FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKG 321 S ++K L+RNLL+ + T+R + + NH W + + + P Sbjct: 229 VSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQSTKVP------QTPLHTSRVL 277 Query: 322 PGDTSNFDDYEEE 334 D ++D +EE Sbjct: 278 KEDKERWEDVKEE 290 >4X3F-A nrPDB Length = 337 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 71/268 (26%), Positives = 118/268 (44%), Gaps = 10/268 (3%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P ++ + + TG G+V G A+K+L + + IE E Sbjct: 3 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 62 Query: 93 KRILQAVNFPFLVKLEYSFK-----DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY 147 R +N P + + + + Y+VME V G + S L+R GR S HA Sbjct: 63 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 122 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT----LCGTP 203 Q + H+ L++RD+KP N+LI G +++TDFG AK V T + GT Sbjct: 123 LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTA 182 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI-YEKIVSGKVRFPSHF 262 +Y+APE L + A D ++LGV+ YE +G PF D + + + I P Sbjct: 183 QYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDL 242 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVN 290 ++++L+ L + R+ + + Sbjct: 243 PPNVRELIEITLVKNPAMRYRSGGPFAD 270 >4OW8-A nrPDB Length = 283 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 71/268 (26%), Positives = 118/268 (44%), Gaps = 10/268 (3%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P ++ + + TG G+V G A+K+L + + IE E Sbjct: 2 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 61 Query: 93 KRILQAVNFPFLVKLEYSFK-----DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY 147 R +N P + + + + Y+VME V G + S L+R GR S HA Sbjct: 62 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 121 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT----LCGTP 203 Q + H+ L++RD+KP N+LI G +++TDFG AK V T + GT Sbjct: 122 LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTA 181 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI-YEKIVSGKVRFPSHF 262 +Y+APE L + A D ++LGV+ YE +G PF D + + + I P Sbjct: 182 QYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDL 241 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVN 290 ++++L+ L + R+ + + Sbjct: 242 PPNVRELIEITLVKNPAMRYRSGGPFAD 269 >3VN9-A nrPDB Length = 340 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 119/272 (43%), Gaps = 21/272 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D E I LG G++G V ++H +G A+K + + V +Q ++ ++ V+ Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDC 109 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSH----LRRIGRFSEPHARFYAAQIVLTFEY 157 PF V + ++++ ME + + + + E A IV E+ Sbjct: 110 PFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 Query: 158 LHSL-DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEII--- 211 LHS +I+RD+KP N+LI+ G +++ DFG + + G Y+APE I Sbjct: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 Query: 212 -LSKGYNKAVDWWALGVLIYEMAAGYPPF--FADQPIQIYEKIVSGKVRFP-SHFSSDLK 267 KGY+ D W+LG+ + E+A P+ + Q+ + + + P FS++ Sbjct: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 D L+ + +R ++ H +F Sbjct: 289 DFTSQCLKKNSKER-----PTYPELMQHPFFT 315 >5HIE-A nrPDB Length = 302 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 122/295 (41%), Gaps = 33/295 (11%) Query: 2 GNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV 61 G+ GSE + + L + D WE P Q + +G+GSFG V Sbjct: 4 GSHHHHHHGSEDRNRMKTLGR--RDSSDDWEIPD------GQITVGQRIGSGSFGTVYKG 55 Query: 62 KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVM 121 K A+K+L +Q++ NE +L+ ++ L + L +V Sbjct: 56 KWHGD---VAVKML------TPQQLQAFKNEVGVLRKTRHVNIL-LFMGYSTKPQLAIVT 105 Query: 122 EYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 ++ G ++ HL I +F A Q +YLH+ +I+RDLK N+ + + Sbjct: 106 QWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLT 165 Query: 181 IQVTDFGFA----KRVKGRTWT-LCGTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEM 232 +++ DFG A + + L G+ ++APE+I Y+ D +A G+++YE+ Sbjct: 166 VKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYEL 225 Query: 233 AAGYPPFFADQPI-QIYEKIVSGKVRFP-----SHFSSDLKDLLRNLLQVDLTKR 281 G P+ QI + G + S+ +K L+ L+ +R Sbjct: 226 MTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDER 280 >4O2Z-A nrPDB Length = 377 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 121/314 (38%), Gaps = 48/314 (15%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ +K LG G++G +TG ++K + ++ + L E +++ + Sbjct: 46 KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKC-RDVFRDVEDGKRVLREIDMMRFFHHE 104 Query: 103 FLVK-------LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 L+ L+ + ++Y+V + +M LR E H +++ QI+ Sbjct: 105 NLLNVVNILPPLKREYHSFEDVYVVTPLMD-VDMNVVLRSRQVLEESHMQYFVYQILRGL 163 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIIL 212 +YLHS ++ +RDLKP NL+ + +++ DFG ++ V T Y PE++L Sbjct: 164 KYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLL 223 Query: 213 SK-GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF--------- 262 Y+ AVD W++G + EM P F + I + P+ Sbjct: 224 ENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEK 283 Query: 263 --------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302 +++ D L + +D +KR D+ H + A Sbjct: 284 LNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKR-----PTAADMLAHPYLAHLH 338 Query: 303 WIAIYQRKVEAPFI 316 + PF+ Sbjct: 339 -DEEDEPTCPCPFL 351 >3C1X-A nrPDB Length = 373 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 49/262 (18%), Positives = 112/262 (42%), Gaps = 21/262 (8%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVK---HKETGNHFAMKILDKQKVVKLKQIEHTL 90 P+ H + + +G G FG V + H A+K L++ + + ++ L Sbjct: 86 PSSLIVHFN-----EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFL 138 Query: 91 NEKRILQAVNFPFLVKLEYSF-KDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYA 148 E I++ + P ++ L + + +V+ Y+ G++ + +R + + Sbjct: 139 TEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFG 198 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTP----- 203 Q+ ++L S ++RDL N ++D++ ++V DFG A+ + + + Sbjct: 199 LQVAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKL 258 Query: 204 --EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFP 259 +++A E + ++ + D W+ GVL++E+ G PP+ I ++ G ++ P Sbjct: 259 PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQP 318 Query: 260 SHFSSDLKDLLRNLLQVDLTKR 281 + L +++ R Sbjct: 319 EYCPDPLYEVMLKCWHPKAEMR 340 >6B2Q-A nrPDB Length = 317 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 71/268 (26%), Positives = 118/268 (44%), Gaps = 10/268 (3%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P ++ + + TG G+V G A+K+L + + IE E Sbjct: 23 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 82 Query: 93 KRILQAVNFPFLVKLEYSFK-----DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY 147 R +N P + + + + Y+VME V G + S L+R GR S HA Sbjct: 83 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 142 Query: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT----LCGTP 203 Q + H+ L++RD+KP N+LI G +++TDFG AK V T + GT Sbjct: 143 LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTA 202 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI-YEKIVSGKVRFPSHF 262 +Y+APE L + A D ++LGV+ YE +G PF D + + + I P Sbjct: 203 QYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDL 262 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVN 290 ++++L+ L + R+ + + Sbjct: 263 PPNVRELIEITLVKNPAMRYRSGGPFAD 290 >4FL3-A nrPDB Length = 635 Score = 213 bits (544), Expect = 7e-56, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 129/302 (42%), Gaps = 21/302 (6%) Query: 12 EQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERI----KTLGTGSFGRVMLVKHK-ET 66 Q + E E +LD+ + + K LG+G+FG V ++ + Sbjct: 336 PQREALPMDTEVFESPFADPEEIRPKEVYLDR-KLLTLEDKELGSGNFGTVKKGYYQMKK 394 Query: 67 GNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPG 126 + K + + L E ++Q ++ P++V++ + S + +VME Sbjct: 395 VVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAEL 453 Query: 127 GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF 186 G + +L++ + + Q+ + +YL + ++RDL N+L+ Q Y +++DF Sbjct: 454 GPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDF 513 Query: 187 GFAKRVK-GRTWTLCGT-----PEYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPF 239 G +K ++ + T ++ APE I ++ D W+ GVL++E + G P+ Sbjct: 514 GLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 Query: 240 FADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFG------NLKNGVNDI 292 + ++ + G ++ P+ ++ DL+ D+ R G L+N D+ Sbjct: 574 RGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 Query: 293 KN 294 N Sbjct: 634 VN 635 >2W1I-A nrPDB Length = 326 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 62/278 (22%), Positives = 119/278 (42%), Gaps = 34/278 (12%) Query: 35 AQNTAHLDQ-FERIKTLGTGSFGRVMLVKHKE----TGNHFAMKILDKQKVVKLKQIEHT 89 T ++ + ++ LG G+FG V + ++ TG A+K L L+ E Sbjct: 33 RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE-- 90 Query: 90 LNEKRILQAVNFPFLVKLEYSFKD--NSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARF 146 E IL+++ +VK + NL ++MEY+P G + +L++ R Sbjct: 91 -REIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQ 149 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPE- 204 Y +QI EYL + I+RDL N+L++ + +++ DFG K + + + + P Sbjct: 150 YTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE 209 Query: 205 ----YLAPEIILSKGYNKAVDWWALGVLIYEMAA-----GYPP--FFADQPIQ------I 247 + APE + ++ A D W+ GV++YE+ PP F + Sbjct: 210 SPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIV 269 Query: 248 YEKIV----SGKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + I +G++ P ++ ++ ++ +R Sbjct: 270 FHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQR 307 >1TKI-A nrPDB Length = 321 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 67/269 (24%), Positives = 117/269 (43%), Gaps = 18/269 (6%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +++ + LG G FG V + + K + VK E IL Sbjct: 4 YEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVK----VKGTDQVLVKKEISILNIAR 59 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLH 159 ++ L SF+ L M+ E++ G ++F + +E Y Q+ ++LH Sbjct: 60 HRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLH 119 Query: 160 SLDLIYRDLKPENLL--IDQQGYIQVTDFGFAKRVK-GRTWTLCGT-PEYLAPEIILSKG 215 S ++ + D++PEN++ + I++ +FG A+++K G + L T PEY APE+ Sbjct: 120 SHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDV 179 Query: 216 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS----HFSSDLKDLLR 271 + A D W+LG L+Y + +G PF A+ QI E I++ + F S + D + Sbjct: 180 VSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVD 239 Query: 272 NLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 LL + R ++ H W Sbjct: 240 RLLVKERKSRM-----TASEALQHPWLKQ 263 >3ALO-A nrPDB Length = 327 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 65/307 (21%), Positives = 133/307 (43%), Gaps = 29/307 (9%) Query: 18 EFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDK 77 E K K + W+ A + + + +G G++G V + HK +G A+K + + Sbjct: 4 ESSGKLKISPEQHWDFTA------EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI-R 56 Query: 78 QKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGG--EMFSHLRR 135 V + +Q + ++ ++++ + P++V+ + + ++ ME + + + ++ Sbjct: 57 STVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYS 116 Query: 136 I--GRFSEPHARFYAAQIVLTFEYL-HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV 192 + E V +L +L +I+RD+KP N+L+D+ G I++ DFG + ++ Sbjct: 117 VLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQL 176 Query: 193 KGR--TWTLCGTPEYLAPEII----LSKGYNKAVDWWALGVLIYEMAAGYPPFFA-DQPI 245 G Y+APE I +GY+ D W+LG+ +YE+A G P+ + Sbjct: 177 VDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVF 236 Query: 246 QIYEKIVSGKVRFPS-----HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 ++V G S FS + + L D +KR ++ H + Sbjct: 237 DQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKR-----PKYKELLKHPFILM 291 Query: 301 TDWIAIY 307 + A+ Sbjct: 292 YEERAVE 298 >3IO7-A nrPDB Length = 313 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 116/269 (43%), Gaps = 33/269 (12%) Query: 43 QFERIKTLGTGSFGRVMLVKHKE----TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 + ++ LG G+FG V + ++ TG A+K L L+ E E IL++ Sbjct: 29 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE---REIEILKS 85 Query: 99 VNFPFLVKLEYSFKD--NSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTF 155 + +VK + NL ++MEY+P G + +L++ R Y +QI Sbjct: 86 LQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 145 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPE-----YLAPE 209 EYL + I+RDL N+L++ + +++ DFG K + + + + P + APE Sbjct: 146 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 205 Query: 210 IILSKGYNKAVDWWALGVLIYEMAA-----GYPP--FFADQPIQ------IYEKIV---- 252 + ++ A D W+ GV++YE+ PP F ++ I Sbjct: 206 SLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKN 265 Query: 253 SGKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 +G++ P ++ ++ ++ +R Sbjct: 266 NGRLPRPDGCPDEIYMIMTECWNNNVNQR 294 >4E20-A nrPDB Length = 290 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 118/285 (41%), Gaps = 33/285 (11%) Query: 40 HLDQFERIKTLGTGSFGRVMLV----KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 H ++I+ LG G FG+V L + TG A+K L + +L+ E I Sbjct: 6 HKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLR--SGWQREIEI 63 Query: 96 LQAVNFPFLVKLEYSFKDNSN--LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153 L+ + +VK + +D + +VMEYVP G + +L R +A QI Sbjct: 64 LRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQICE 122 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLC-----GTPEYLA 207 YLH+ I+R L N+L+D +++ DFG AK V +G + + A Sbjct: 123 GMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYA 182 Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAA----GYPPFF-----------ADQPIQIYEKIV 252 PE + + A D W+ GV +YE+ P +++ E + Sbjct: 183 PECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLE 242 Query: 253 SG-KVRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKN 294 G ++ P ++ L++N + + + R F NL + + Sbjct: 243 RGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQE 287 >3MIA-A nrPDB Length = 351 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 64/310 (20%), Positives = 121/310 (39%), Gaps = 60/310 (19%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 + ++E++ +G G+FG V +H++TG A+K + + K L E +ILQ + Sbjct: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLL 73 Query: 100 NFPFLVKLEYSFKDN--------SNLYMVMEYVPG---GEMFSHLRRIGRFSEPHARFYA 148 +V L + ++Y+V ++ G + + L + F+ + Sbjct: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVM 130 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-------KGRTWTLCG 201 ++ Y+H +++RD+K N+LI + G +++ DFG A+ R Sbjct: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Query: 202 TPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS--GKVRF 258 T Y PE++L + Y +D W G ++ EM P + I G + Sbjct: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 Query: 259 ---PSHFSSDLK---------------------------DLLRNLLQVDLTKRFGNLKNG 288 P+ + +L DL+ LL +D +R + Sbjct: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS---- 306 Query: 289 VNDIKNHKWF 298 +D NH +F Sbjct: 307 -DDALNHDFF 315 >1S9I-A nrPDB Length = 354 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 124/309 (40%), Gaps = 57/309 (18%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D FERI LG G+ G V V+H+ +G A K++ + +K + E ++L N Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE--IKPAIRNQIIRELQVLHECNS 73 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL-HS 160 P++V +F + + + ME++ GG + L+ R E + ++ YL Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK 133 Query: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR-VKGRTWTLCGTPEYLAPEIILSKGYNKA 219 +++RD+KP N+L++ +G I++ DFG + + + + GT Y+APE + Y+ Sbjct: 134 HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQ 193 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPI---------------------------------- 245 D W++G+ + E+A G P Sbjct: 194 SDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSG 253 Query: 246 ------------QIYEKIVSGKVRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVND 291 ++ + IV+ + F+ D ++ + L + +R + Sbjct: 254 HGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAER-----ADLKM 308 Query: 292 IKNHKWFAT 300 + NH + Sbjct: 309 LTNHTFIKR 317 >5AIR-A nrPDB Length = 430 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 76/339 (22%), Positives = 132/339 (38%), Gaps = 56/339 (16%) Query: 7 AKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQ--FERIKTLGTGSFGRVMLVKHK 64 ++ S S+K + K P Q + + K +G GSFG V K Sbjct: 27 VQQPSAFGSMKVSIDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLC 86 Query: 65 ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF------KDNSNLY 118 ++G A+K + + K K E +I++ ++ +V+L Y F KD L Sbjct: 87 DSGELVAIKKVLQDKRFKN-------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLN 139 Query: 119 MVMEYVP---GGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI 175 +V++YVP + R + + Y Q+ + Y+HS + +RD+KP+NLL+ Sbjct: 140 LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 199 Query: 176 DQQGYI-QVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYE 231 D + ++ DFG AK++ + + Y APE+I Y ++D W+ G ++ E Sbjct: 200 DPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAE 259 Query: 232 MAAGYPPFFADQPIQIYEKIVSG-----------------KVRFP------------SHF 262 + G P F D + +I+ + +FP Sbjct: 260 LLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRT 319 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 + L LL+ T R L+ H +F Sbjct: 320 PPEAIALCSRLLEYTPTARLTPLEACA-----HSFFDEL 353 >3FME-A nrPDB Length = 290 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 119/272 (43%), Gaps = 21/272 (7%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D E I LG G++G V ++H +G A+K + + V +Q ++ ++ V+ Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDC 65 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSH----LRRIGRFSEPHARFYAAQIVLTFEY 157 PF V + ++++ ME + + + + E A IV E+ Sbjct: 66 PFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 124 Query: 158 LHSL-DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEII--- 211 LHS +I+RD+KP N+LI+ G +++ DFG + + G Y+APE I Sbjct: 125 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPE 184 Query: 212 -LSKGYNKAVDWWALGVLIYEMAAGYPPF--FADQPIQIYEKIVSGKVRFP-SHFSSDLK 267 KGY+ D W+LG+ + E+A P+ + Q+ + + + P FS++ Sbjct: 185 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 244 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 D L+ + +R ++ H +F Sbjct: 245 DFTSQCLKKNSKER-----PTYPELMQHPFFT 271 >4LRM-A nrPDB Length = 334 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 60/268 (22%), Positives = 119/268 (44%), Gaps = 21/268 (7%) Query: 32 ENPAQNTAHL---DQFERIKTLGTGSFGRVMLVKHKETGNHF----AMKILDKQKVVKLK 84 E P Q + +F++IK LG+G+FG V G A+K L ++ K Sbjct: 6 EAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL--REATSPK 63 Query: 85 QIEHTLNEKRILQAVNFP---FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFS 140 + L+E ++ +V+ P + +L ++ + ++ + +P G + ++R Sbjct: 64 ANKEILDEAYVMASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIG 122 Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWT 198 + + QI YL L++RDL N+L+ ++++TDFG AK + + + + Sbjct: 123 SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYH 182 Query: 199 LCG---TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG 254 G +++A E IL + Y D W+ GV ++E+ G P+ +I + G Sbjct: 183 AEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG 242 Query: 255 -KVRFPSHFSSDLKDLLRNLLQVDLTKR 281 ++ P + D+ ++ +D R Sbjct: 243 ERLPQPPICTIDVYMIMVKCWMIDADSR 270 >3AOX-A nrPDB Length = 344 Score = 210 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 109/272 (40%), Gaps = 30/272 (11%) Query: 32 ENPAQNTAHLDQFERIKTLGTGSFGRVMLVK-----HKETGNHFAMKILDKQKVVKLKQI 86 E P +N I+ LG G+FG V + + + A+K L +V + Sbjct: 43 EVPRKNI------TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP--EVCSEQDE 94 Query: 87 EHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-------F 139 L E I+ N +V+ + ++++E + GG++ S LR Sbjct: 95 LDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSL 154 Query: 140 SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG---YIQVTDFGFAKRVKGRT 196 + A I +YL I+RD+ N L+ G ++ DFG A+ + + Sbjct: 155 AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAS 214 Query: 197 WTLCG-----TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEK 250 + G +++ PE + + D W+ GVL++E+ + GY P+ + ++ E Sbjct: 215 YYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEF 274 Query: 251 IVS-GKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + S G++ P + + ++ Q R Sbjct: 275 VTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR 306 >1ZXE-A nrPDB Length = 303 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 133/313 (42%), Gaps = 49/313 (15%) Query: 37 NTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL 96 + + FE I LG G+FG+V+ ++ ++A+K + +++ L+E +L Sbjct: 1 SLRYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH----TEEKLSTILSEVMLL 56 Query: 97 QAVNFPFLVKLEYSFKDNSN-------------LYMVMEYVPGGEMFSHLRRIG-RFSEP 142 ++N ++V+ ++ + N L++ MEY ++ + Sbjct: 57 ASLNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRD 116 Query: 143 HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--------- 193 QI+ Y+HS +I+R+LKP N+ ID+ +++ DFG AK V Sbjct: 117 EYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLD 176 Query: 194 --------GRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-ADQ 243 + GT Y+A E++ YN+ +D ++LG++ +EM PF + Sbjct: 177 SQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGME 233 Query: 244 PIQIYEKIVSGKVRFPSHFSSDL----KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 + I +K+ S + FP F + K ++R L+ D KR G + N W Sbjct: 234 RVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKR-----PGARTLLNSGWLP 288 Query: 300 TTDWIAIYQRKVE 312 + + ++ Sbjct: 289 VKHQDEVIKEALK 301 >4HVI-A nrPDB Length = 314 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 63/268 (23%), Positives = 112/268 (41%), Gaps = 32/268 (11%) Query: 43 QFERIKTLGTGSFGRVMLVKHKE----TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 + I LG G+FG V L ++ TG A+K L Q E +IL+A Sbjct: 11 HLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSG---PDQQRDFQREIQILKA 67 Query: 99 VNFPFLVKLEYSFKDNSN--LYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTF 155 ++ F+VK L +VMEY+P G + L+R R Y++QI Sbjct: 68 LHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGM 127 Query: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GRTWTLCGTPE-----YLAPE 209 EYL S ++RDL N+L++ + ++++ DFG AK + + + + P + APE Sbjct: 128 EYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPE 187 Query: 210 IILSKGYNKAVDWWALGVLIYEMAA----GYPP---FFADQPIQ---------IYEKIVS 253 + +++ D W+ GV++YE+ P F + + Sbjct: 188 SLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEG 247 Query: 254 GKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 ++ P +++ +L++ R Sbjct: 248 QRLPAPPACPAEVHELMKLCWAPSPQDR 275 >2W96-B nrPDB Length = 306 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 116/294 (39%), Gaps = 46/294 (15%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-- 100 ++E + +G G++G V + +G+ A+K + + I T+ E +L+ + Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPIS-TVREVALLRRLEAF 63 Query: 101 -FPFLVKLEYSFKDNS-----NLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIV 152 P +V+L + + +V E+V ++ ++L + + Q + Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEI 210 ++LH+ +++RDLKPEN+L+ G +++ DFG A+ + + T Y APE+ Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS----------------G 254 +L Y VD W++G + EM P F + KI Sbjct: 183 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 242 Query: 255 KVRFPSHFSSDLKD-----------LLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297 + FP ++ LL +L + KR + H + Sbjct: 243 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR-----ALQHSY 291 >3QA8-A nrPDB Length = 676 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 70/237 (29%), Positives = 113/237 (47%), Gaps = 17/237 (7%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P+ T +E + LGTG FG V+ H++TG A+K ++ + K E E Sbjct: 5 SPSLPTQTCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQE--LSPKNRERWCLE 62 Query: 93 KRILQAVNFPFLVKLEYS------FKDNSNLYMVMEYVPGGEMFSHLRRIGR---FSEPH 143 +I++ +N P +V N + MEY GG++ +L + E Sbjct: 63 IQIMKKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGP 122 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKGRT--WT 198 R + I YLH +I+RDLKPEN+++ Q+ ++ D G+AK + Sbjct: 123 IRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTE 182 Query: 199 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD-QPIQIYEKIVSG 254 GT +YLAPE++ K Y VD+W+ G L +E G+ PF + QP+Q + K+ Sbjct: 183 FVGTLQYLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREK 239 >4KIK-B nrPDB Length = 677 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 73/287 (25%), Positives = 130/287 (45%), Gaps = 40/287 (13%) Query: 33 NPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE 92 +P+ T +E + LGTG FG V+ ++ETG A+K ++ + + E E Sbjct: 10 SPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQE--LSPRNRERWCLE 67 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNL------YMVMEYVPGGEMFSHLRRIGR---FSEPH 143 +I++ + P +V + NL + MEY GG++ +L + E Sbjct: 68 IQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGA 127 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI---DQQGYIQVTDFGFAKRVKGRT--WT 198 + I YLH +I+RDLKPEN+++ +Q+ ++ D G+AK + + + Sbjct: 128 ILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTS 187 Query: 199 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD-QPIQIYEKIVSG--- 254 GT +YLAPE++ + Y VD+W+ G L +E G+ PF + QP+Q + K+ Sbjct: 188 FVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEV 247 Query: 255 ----------------KVRFPSHFSSDLKDLLRN----LLQVDLTKR 281 + +P++ +S L + L +L +R Sbjct: 248 DIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQR 294 >6FER-A nrPDB Length = 309 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 58/290 (20%), Positives = 103/290 (35%), Gaps = 48/290 (16%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGN----------------HFAMKILDKQKVVKLKQIE 87 + LG G FG V L + + A+K+L + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARN-- 68 Query: 88 HTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--------- 138 L E +I+ + P ++ L + L M+ EY+ G++ L R Sbjct: 69 DFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVR 128 Query: 139 -FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW 197 S + +F A QI +YL SL+ ++RDL N L+ + I++ DFG ++ + + Sbjct: 129 TVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDY 188 Query: 198 TLCGTP-----EYLAPEIILSKGYNKAVDWWALGVLIYE--MAAGYPPFFADQPIQIYEK 250 +++ E IL + A D WA GV ++E P+ Q+ E Sbjct: 189 YRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIEN 248 Query: 251 I--------VSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 + P+ + L+ + + D R +I Sbjct: 249 TGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNR-----PSFQEI 293 >5C26-A nrPDB Length = 299 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 60/282 (21%), Positives = 126/282 (44%), Gaps = 21/282 (7%) Query: 32 ENPAQNTAHLDQFERI----KTLGTGSFGRVMLVKHK-ETGNHFAMKILDKQKVVKLKQI 86 E +LD+ + + K LG+G+FG V ++ + + K + Sbjct: 14 EEIRPKEVYLDR-KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK 72 Query: 87 EHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 146 + L E ++Q ++ P++V++ + S + +VME G + +L++ + + Sbjct: 73 DELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIE 131 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GRTWTLCGT--- 202 Q+ + +YL + ++RDL N+L+ Q Y +++DFG +K ++ + T Sbjct: 132 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 191 Query: 203 --PEYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRF 258 ++ APE I ++ D W+ GVL++E + G P+ + ++ + G ++ Sbjct: 192 WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC 251 Query: 259 PSHFSSDLKDLLRNLLQVDLTKRFG------NLKNGVNDIKN 294 P+ ++ DL+ D+ R G L+N D+ N Sbjct: 252 PAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 293 >5Y86-A nrPDB Length = 588 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 127/335 (37%), Gaps = 81/335 (24%) Query: 34 PAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEK 93 P + A+ ++E +K +G GSFG+V V + + A+K++ +K + E E Sbjct: 201 PRDHLAY--RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE----EI 254 Query: 94 RILQAVN------FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHAR 145 RIL+ + ++ + SF +++ M E + +++ +++ FS R Sbjct: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVR 313 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY--IQVTDFGFAKRVKGRTWTLCGTP 203 +A I+ + + LH +I+ DLKPEN+L+ G +V DFG + + +T + Sbjct: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR 373 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQ---------------PIQIY 248 Y APEIIL Y+ +D W+ G ++ E+ G P F + P ++ Sbjct: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL 433 Query: 249 EKIVSGKV-----RFPSHFSSD-------------------------------------- 265 E+ K P + S Sbjct: 434 EQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 493 Query: 266 -LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 + L+ L D + R H W + Sbjct: 494 LFIEFLKRCLHWDPSARLTP-----AQALRHPWIS 523 >5VD3-A nrPDB Length = 311 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 74/290 (25%), Positives = 122/290 (42%), Gaps = 11/290 (3%) Query: 13 QESVKEFLAKAKEDFLKKWENPAQNTAHLDQ-FERIKTLGTGSFGRVMLVKHKETGNHFA 71 Q F +A E +P++ + Q F+R+ LG GS+G V V+ KE G +A Sbjct: 27 QPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYA 86 Query: 72 MKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMF 130 +K K L E + V P V+LE ++++ LY+ E G + Sbjct: 87 VKR-SMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELC-GPSLQ 144 Query: 131 SHLRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA 189 H G E Y +L +LHS L++ D+KP N+ + +G ++ DFG Sbjct: 145 QHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLL 204 Query: 190 KRV--KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAG-YPPFFADQPIQ 246 + G G P Y+APE +L Y A D ++LG+ I E+A P + Q Sbjct: 205 VELGTAGAGEVQEGDPRYMAPE-LLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQ 263 Query: 247 IYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHK 296 + + + + + SS+L+ +L +L+ D R + Sbjct: 264 LRQGYLPPEFT--AGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQP 311 >5TQX-A nrPDB Length = 655 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 84/294 (28%), Positives = 131/294 (44%), Gaps = 44/294 (14%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 +E + LGTG FG V L +H+E A+K + + K E +E +I++ +N Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLE--LSTKNRERWCHEIQIMKKLNHAN 67 Query: 104 LVKLEYSFKD-----NSNLYMVMEYVPGGEMFSHLRR---IGRFSEPHARFYAAQIVLTF 155 +VK ++ + + MEY GG++ L + E + I Sbjct: 68 VVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGI 127 Query: 156 EYLHSLDLIYRDLKPENLLI-DQQGYI--QVTDFGFAKRVKGRT--WTLCGTPEYLAPEI 210 YLH +I+RDLKPEN+++ D G I ++ D G+AK V GT +YLAPE+ Sbjct: 128 RYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPEL 187 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD-QPIQIYEKIVS-------------GKV 256 +K Y VD+W+ G +++E AGY PF QP +EKI G+V Sbjct: 188 FENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEV 247 Query: 257 RFPSHFSS--DLKDLL--------RNLLQVDLTKRFGNLKNGVND-----IKNH 295 RF SH L L+ + +L D +R G + + + +H Sbjct: 248 RFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDH 301 >3OMV-A nrPDB Length = 307 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 120/291 (41%), Gaps = 29/291 (9%) Query: 22 KAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVV 81 + + D WE A + +G+GSFG V K A+KIL K Sbjct: 22 RGQRDSSYYWEIEASEVMLSTR------IGSGSFGTVYKGKWHGD---VAVKIL-KVVDP 71 Query: 82 KLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFS 140 +Q + NE +L+ ++ L + NL +V ++ G ++ HL + +F Sbjct: 72 TPEQFQAFRNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQ 130 Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----RVKGR 195 A Q +YLH+ ++I+RD+K N+ + + +++ DFG A + Sbjct: 131 MFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQ 190 Query: 196 TWTLCGTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252 G+ ++APE+I + ++ D ++ G+++YE+ G P+ +V Sbjct: 191 VEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMV 250 Query: 253 SGKVRFPS------HFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNH 295 P + +K L+ + ++ +R F + + + ++ H Sbjct: 251 GRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI-ELLQH 300 >5WNO-A nrPDB Length = 330 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 61/252 (24%), Positives = 101/252 (40%), Gaps = 17/252 (6%) Query: 45 ERIKTLGTGSFGRVMLVKH-----KETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 + K LG G+FG V + K A+K+ Q + L E + + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ----TDQSQTDEMLEEATNMFRL 80 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYL 158 L+K+ + L +V Y P G + + L+ Y QI +YL Sbjct: 81 RHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYL 140 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC-----GTPEYLAPEIILS 213 +++RDL N+L+ + ++++TDFG +K +K ++ ++LA EI Sbjct: 141 EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 214 KGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLR 271 Y A D WA GV +E+ G P+ I+ + G ++ P + S DL L Sbjct: 201 HCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELL 260 Query: 272 NLLQVDLTKRFG 283 D R G Sbjct: 261 RCWMADPKSRPG 272 >2I6L-A nrPDB Length = 320 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 126/313 (40%), Gaps = 62/313 (19%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ +K LG G G V + A+K + + + ++H L E +I++ ++ Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALREIKIIRRLDHD 68 Query: 103 FLVKLE--------------YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYA 148 +VK+ S + +++Y+V EY+ ++ + L G E HAR + Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVL-EQGPLLEEHARLFM 126 Query: 149 AQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRV------KGRTWTLCG 201 Q++ +Y+HS ++++RDLKP NL I+ + +++ DFG A+ + KG Sbjct: 127 YQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLV 186 Query: 202 TPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS------- 253 T Y +P ++LS Y KA+D WA G + EM G F ++ + I+ Sbjct: 187 TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHE 246 Query: 254 ---------------GKVRFP--------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 290 + P S + D L +L R Sbjct: 247 EDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRL-----TAE 301 Query: 291 DIKNHKWFATTDW 303 + +H + + + Sbjct: 302 EALSHPYMSIYSF 314 >4TPT-A nrPDB Length = 303 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 118/277 (42%), Gaps = 33/277 (11%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 + LG G FG+ + V HK TG MK L + + + L E +++++++ P Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIR---CDEETQKTFLTEVKVMRSLDHP 57 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 ++K + L ++ EY+ GG + LR + F +A I YLHS+ Sbjct: 58 NVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMC 117 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----------------------KGRTWTL 199 +I+RDL N LI + V DFG ++ + + + +T+ Sbjct: 118 IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTV 177 Query: 200 CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV--- 256 G P ++APE++ K Y++ VD ++ G+++ E+ G D + + ++ K+ Sbjct: 178 VGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQVYADPDCLPRTLDFGLNVKLFWE 236 Query: 257 -RFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVN 290 P+ L +++ R F L++ Sbjct: 237 KFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFE 273 >4E7W-A nrPDB Length = 394 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 73/317 (23%), Positives = 124/317 (39%), Gaps = 58/317 (18%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + K +G GSFG V K E+ A+K + + K K E +I++ V P Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN-------RELQIMRIVKHPN 93 Query: 104 LVKLEYSFKDNSN------LYMVMEYVP---GGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 +V L+ F N + L +V+EYVP + + + Y Q++ + Sbjct: 94 VVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRS 153 Query: 155 FEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEII 211 Y+HS+ + +RD+KP+NLL+D G +++ DFG AK + + + Y APE+I Sbjct: 154 LAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELI 213 Query: 212 LS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---------------- 254 Y +D W+ G ++ E+ G P F + I +I+ Sbjct: 214 FGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNY 273 Query: 255 -KVRFP------------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 + +FP D DL+ LL+ + R + H +F Sbjct: 274 MEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARL-----TAIEALCHPFFDEL 328 Query: 302 DW---IAIYQRKVEAPF 315 R++ F Sbjct: 329 RTGEARMPNGRELPPLF 345 >5HVK-A nrPDB Length = 315 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 120/276 (43%), Gaps = 26/276 (9%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 + LG G FG+ + V H+ETG MK L + + L E ++++ + P Sbjct: 15 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR---FDEETQRTFLKEVKVMRCLEHP 71 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHSL 161 ++K + L + EY+ GG + ++ + ++ +A I YLHS+ Sbjct: 72 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM 131 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----------------RTWTLCGTPE 204 ++I+R+L N L+ + + V DFG A+ + + +T+ G P Sbjct: 132 NIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPY 191 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYP--PFFADQPIQIYEKIVSGKVRF-PSH 261 ++APE+I + Y++ VD ++ G+++ E+ P + + + + R+ P + Sbjct: 192 WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPN 251 Query: 262 FSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNH 295 + +D KR F L++ + ++ H Sbjct: 252 CPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMH 287 >6GVJ-A nrPDB Length = 429 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 124/277 (44%), Gaps = 30/277 (10%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV--NF 101 + +K +G+G +V V + E +A+K ++ ++ + ++ NE L + + Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHS 203 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 +++L + +YMVME ++ S L++ + Y ++ +H Sbjct: 204 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 262 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL-----CGTPEYLAPEIILSKGY 216 +++ DLKP N LI G +++ DFG A +++ T ++ GT Y+ PE I Sbjct: 263 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 321 Query: 217 NKA-----------VDWWALGVLIYEMAAGYPPFFA--DQPIQIYEKIV-SGKVRFPSHF 262 ++ D W+LG ++Y M G PF +Q +++ I + ++ FP Sbjct: 322 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 381 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 DL+D+L+ L+ D +R + ++ H + Sbjct: 382 EKDLQDVLKCCLKRDPKQRI-----SIPELLAHPYVQ 413 >5B2L-A nrPDB Length = 324 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 133/281 (47%), Gaps = 18/281 (6%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 A ++ E + +G+G+ G+V ++ ++TG+ A+K + ++ K + ++ +L+ Sbjct: 13 QAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQM-RRSGNKEENKRILMDLDVVLK 71 Query: 98 AVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 + + P++V+ +F N+++++ ME + R G E IV Y Sbjct: 72 SHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYY 131 Query: 158 L-HSLDLIYRDLKPENLLIDQQGYIQVTDFGFA-KRVKGRTWT-LCGTPEYLAPEII--- 211 L +I+RD+KP N+L+D++G I++ DFG + + V + T G Y+APE I Sbjct: 132 LKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPP 191 Query: 212 --LSKGYNKAVDWWALGVLIYEMAAGYPPFF-ADQPIQIYEKIVSGKVR-FPSH--FSSD 265 Y+ D W+LG+ + E+A G P+ ++ K++ + P H FS D Sbjct: 192 DPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGD 251 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAI 306 + +++ L D KR N + H + + + + Sbjct: 252 FQSFVKDCLTKDHRKR-----PKYNKLLEHSFIKRYETLEV 287 >5ZTN-A nrPDB Length = 429 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 73/327 (22%), Positives = 124/327 (37%), Gaps = 79/327 (24%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV--- 99 ++E +K +G GSFG+V+ + H A+K++ +K + E E RIL+ + Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAE----EIRILEHLRKQ 153 Query: 100 ---NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLT 154 N ++ + +F +++ M E + ++ +++ FS P R +A I+ Sbjct: 154 DKDNTMNVIHMLENFTFRNHICMTFELLS-MNLYELIKKNKFQGFSLPLVRKFAHSILQC 212 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGY--IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 212 + LH +I+ DLKPEN+L+ QQG I+V DFG + R +T + Y APE+IL Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVIL 272 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS------------------- 253 Y +D W+LG ++ E+ GYP + ++ Sbjct: 273 GARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNF 332 Query: 254 -----------------------------GKVRFPSHF-----------SSDLKDLLRNL 273 GK+R P D L+ Sbjct: 333 VSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQC 392 Query: 274 LQVDLTKRFGNLKNGVNDIKNHKWFAT 300 L+ D R + H W Sbjct: 393 LEWDPAVRMTPGQ-----ALRHPWLRR 414 >4F0G-A nrPDB Length = 287 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 62/283 (21%), Positives = 123/283 (43%), Gaps = 24/283 (8%) Query: 32 ENPAQNTAHL--DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKIL----DKQKVVKLKQ 85 E P L ++ E K +G G FG V + + + A+K L + + +++ Sbjct: 7 EFPKSRLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEK 66 Query: 86 IEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSH-LRRIGRFSEPHA 144 + E I+ +N P +VKL + MVME+VP G+++ L + Sbjct: 67 FQEFQREVFIMSNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVK 124 Query: 145 RFYAAQIVLTFEYLHSLD--LIYRDLKPENLL---IDQQGYI--QVTDFGFAKRVKGRTW 197 I L EY+ + + +++RDL+ N+ +D+ + +V DFG +++ Sbjct: 125 LRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVS 184 Query: 198 TLCGTPEYLAPEII--LSKGYNKAVDWWALGVLIYEMAAGYPPF--FADQPIQIYEKIVS 253 L G +++APE I + Y + D ++ +++Y + G PF ++ I+ I Sbjct: 185 GLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIRE 244 Query: 254 GKVRF--PSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDI 292 +R P L++++ D KR F + ++++ Sbjct: 245 EGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKELSEL 287 >3E3P-A nrPDB Length = 360 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 64/341 (18%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRI 95 ++ +D+F+ + G G+FG V L K K TG A+K + + + ++++ + Sbjct: 17 RSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQD---- 72 Query: 96 LQAVNFPFLVKLEYSF-----KDNSNLYM--VMEYVP---GGEMFSHLRRIGRFSEPHAR 145 L ++ P +V+L+ F +D ++Y+ VMEYVP ++ RR + Sbjct: 73 LAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIK 132 Query: 146 FYAAQIVLTFEYLH--SLDLIYRDLKPENLLIDQ-QGYIQVTDFGFAKRVKGRTWTLCG- 201 + Q++ + LH S+++ +RD+KP N+L+++ G +++ DFG AK++ + Sbjct: 133 VFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYI 192 Query: 202 -TPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF- 258 + Y APE+I + Y AVD W++G + EM G P F D +IV Sbjct: 193 CSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPS 252 Query: 259 --------PSH----------------FSS-------DLKDLLRNLLQVDLTKRFGNLKN 287 PSH FS + DLL LLQ +R Sbjct: 253 REVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKP--- 309 Query: 288 GVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 328 + H +F ++ + P P D F Sbjct: 310 --YEALCHPYF-----DELHDPATKLPNNKDL--PEDLFRF 341 >3HMP-A nrPDB Length = 342 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 124/277 (44%), Gaps = 30/277 (10%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV--NF 101 + +K +G+G +V V + E +A+K ++ ++ + ++ NE L + + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHS 115 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 +++L + +YMVME ++ S L++ + Y ++ +H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL-----CGTPEYLAPEIILSKGY 216 +++ DLKP N LI G +++ DFG A +++ T ++ GT Y+ PE I Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 233 Query: 217 NKA-----------VDWWALGVLIYEMAAGYPPFFA--DQPIQIYEKIV-SGKVRFPSHF 262 ++ D W+LG ++Y M G PF +Q +++ I + ++ FP Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 DL+D+L+ L+ D +R + ++ H + Sbjct: 294 EKDLQDVLKCCLKRDPKQRI-----SIPELLAHPYVQ 325 >5O0Y-A nrPDB Length = 579 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 68/258 (26%), Positives = 109/258 (42%), Gaps = 30/258 (11%) Query: 55 FGRVMLVKHKETGNHFAMKI--LDKQKVVKLKQ--IEHTLNEKRILQAVNFPFLVKLEYS 110 F V + A+KI L+K + K+ +H E RI + ++ P +VKL Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 111 FK-DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD--LIYRD 167 F D + V+EY G ++ +L++ SE AR QIV +YL+ + +I+ D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 168 LKPENLLIDQQ---GYIQVTDFGFAKRVKGRTWTLC----------GTPEYLAPEIILSK 214 LKP N+L+ G I++TDFG +K + ++ GT YL PE + Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG 476 Query: 215 ----GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ------IYEKIVSGKVRFPSHFSS 264 + VD W++GV+ Y+ G PF +Q Q K + + Sbjct: 477 KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTP 536 Query: 265 DLKDLLRNLLQVDLTKRF 282 + K +R L R Sbjct: 537 EAKAFIRRCLAYRKEDRI 554 >3RP9-A nrPDB Length = 458 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 83/451 (18%), Positives = 152/451 (33%), Gaps = 134/451 (29%) Query: 2 GNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV 61 G ++ ++ +K P + D++E +GTGS+G V Sbjct: 15 GTQHTVSGSQQEGQQRKQHHSSKPTASMP--RPHSDWQIPDRYEIRHLIGTGSYGHVCEA 72 Query: 62 KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF-----KDNSN 116 K A+K + + L + L E IL +N +VK+ + Sbjct: 73 YDKLEKRVVAIKKI-LRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKDVEKFDE 131 Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID 176 LY+V+E + + R +E H + +++ +Y+HS +++RDLKP N L++ Sbjct: 132 LYVVLE-IADSDFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVN 190 Query: 177 QQGYIQVTDFGFAK------------------------------RVKGRTWTLCGTPEYL 206 Q ++V DFG A+ +K + T Y Sbjct: 191 QDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYR 250 Query: 207 APEII-LSKGYNKAVDWWALGVLIYEMAA-----------GYPPFFA------------- 241 APE+I L + Y +A+D W++G + E+ P F Sbjct: 251 APELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAG 310 Query: 242 -------------------------DQPIQIYEKIVSGKV--------------RFPSHF 262 ++ I+ EK + + RFP+ Sbjct: 311 NDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGTDLAERFPAS- 369 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT------------------DWI 304 S+D LL+ +L + KR +N+ H +F DW+ Sbjct: 370 SADAIHLLKRMLVFNPNKRI-----TINECLAHPFFKEVRIAEVETNATEKVRLPFNDWM 424 Query: 305 AIYQRKVEAPFI-------PKFKGPGDTSNF 328 + + ++ F+ P+ + P + N Sbjct: 425 NMDEPQLRYAFVKEIQRYHPEIQLPRRSPNR 455 >5X8I-B nrPDB Length = 346 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 80/329 (24%), Positives = 134/329 (40%), Gaps = 82/329 (24%) Query: 43 QFERIKTLGTGSFGRVMLVK-HKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN- 100 ++E + TLG G+FG+V+ HK G H A+KI+ + E +E ++L+ +N Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN----VDRYCEAARSEIQVLEHLNT 69 Query: 101 -FPF----LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVL 153 P V++ F+ + ++ +V E + G + ++ G F H R A QI Sbjct: 70 TDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGY-------------------IQVTDFGFAKRVKG 194 + +LHS L + DLKPEN+L Q Y I+V DFG A Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDE 188 Query: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ---IYEKI 251 TL T Y APE+IL+ G+++ D W++G ++ E G+ F + + E+I Sbjct: 189 HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERI 248 Query: 252 VSG------------------KVRFPSHFS-----------------------SDLKDLL 270 + ++ + H S L DL+ Sbjct: 249 LGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLI 308 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 + +L+ D KR + + H +F Sbjct: 309 QKMLEYDPAKRI-----TLREALKHPFFD 332 >5AP3-A nrPDB Length = 313 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 60/277 (21%), Positives = 123/277 (44%), Gaps = 30/277 (10%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV--NF 101 + +K +G+G +V V + E +A+K ++ ++ + ++ NE L + + Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHS 87 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 +++L + +YMVME ++ L++ + Y ++ +H Sbjct: 88 DKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 146 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL-----CGTPEYLAPEIILSKGY 216 +++ DLKP N LI G +++ DFG A +++ T ++ GT Y+ PE I Sbjct: 147 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 205 Query: 217 NKA-----------VDWWALGVLIYEMAAGYPPFFA--DQPIQIYEKIV-SGKVRFPSHF 262 ++ D W+LG ++Y M G PF +Q +++ I + ++ FP Sbjct: 206 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 265 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 DL+D+L+ L+ D +R + ++ H + Sbjct: 266 EKDLQDVLKCCLKRDPKQRI-----SIPELLAHPYVQ 297 >2WO6-A nrPDB Length = 382 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 63/238 (26%), Positives = 112/238 (47%), Gaps = 17/238 (7%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +D++E +G GSFG+V+ + A+KI+ +K + E R+L+ +N Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAF----LNQAQIEVRLLELMN 108 Query: 101 -FP-----FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIV 152 ++V L+ F ++L +V E + ++ LR S R +A Q+ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 153 LTFEYLH--SLDLIYRDLKPENLLI--DQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAP 208 +L L +I+ DLKPEN+L+ ++ I++ DFG + ++ R + + Y +P Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSP 227 Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDL 266 E++L Y+ A+D W+LG ++ EM G P F + KIV P+H Sbjct: 228 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQA 285 Score = 31.8 bits (71), Expect = 0.45, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 12/36 (33%), Gaps = 5/36 (13%) Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 KDL+ +L D R H +F T Sbjct: 349 FKDLILRMLDYDPKTRIQPYY-----ALQHSFFKKT 379 >3N9X-A nrPDB Length = 432 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 69/367 (18%), Positives = 127/367 (34%), Gaps = 100/367 (27%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D + +G GS+G V L K T + A+K +++ L + L E IL + Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRM-FEDLIDCKRILREITILNRLKS 84 Query: 102 PFLVKLEYSFKDNS-----NLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 ++++L + LY+V+E + ++ + +E H + ++L Sbjct: 85 DYIIRLYDLIIPDDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEEHIKTILYNLLLGEN 143 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT------------------ 198 ++H +I+RDLKP N L++Q ++V DFG A+ + T Sbjct: 144 FIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203 Query: 199 -------LCGTPEYLAPEII-LSKGYNKAVDWWALGVLIYEMA-----------AGYPPF 239 T Y APE+I L + Y K++D W+ G + E+ +P F Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLF 263 Query: 240 FAD-----------------------------------------QPIQIYEKIVSGKVRF 258 ++ + I R Sbjct: 264 PGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRK 323 Query: 259 P-------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ--- 308 P S D +LL ++L+ + KR ++ +H + + Sbjct: 324 PINLKQKYPSISDDGINLLESMLKFNPNKRI-----TIDQALDHPYLKDVRKKKLENFST 378 Query: 309 RKVEAPF 315 +K+ PF Sbjct: 379 KKIILPF 385 >2ZMD-A nrPDB Length = 390 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 60/277 (21%), Positives = 123/277 (44%), Gaps = 30/277 (10%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV--NF 101 + +K +G+G +V V + E +A+K ++ ++ + ++ NE L + + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHS 115 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161 +++L + +YMVME ++ S L++ + Y ++ +H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL-----CGTPEYLAPEIILSKGY 216 +++ DLKP N LI G +++ DFG A +++ T ++ G Y+ PE I Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSS 233 Query: 217 NKA-----------VDWWALGVLIYEMAAGYPPFFA--DQPIQIYEKIV-SGKVRFPSHF 262 ++ D W+LG ++Y M G PF +Q +++ I + ++ FP Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 DL+D+L+ L+ D +R + ++ H + Sbjct: 294 EKDLQDVLKCCLKRDPKQRI-----SIPELLAHPYVQ 325 >4M7I-A nrPDB Length = 299 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 117/298 (39%), Gaps = 44/298 (14%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA 98 +L FE I+ LG G FG V K+K ++A+K + + E + E + L Sbjct: 2 RYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRL--PNRELAREKVMREVKALAK 59 Query: 99 VNFPFLVKLEYSFKDNS------------NLYMVMEYVPGGEMFSHLRRIGRFSEPH--- 143 + P +V+ ++ + + LY+ M+ + + E Sbjct: 60 LEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSV 119 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK---------- 193 QI E+LHS L++RDLKP N+ ++V DFG + Sbjct: 120 CLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLT 179 Query: 194 -----GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY 248 R GT Y++PE I Y+ VD ++LG++++E+ PF + Q ++ Sbjct: 180 PMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLY---PF-STQMERVR 235 Query: 249 EKIVSGKVRFPSHFS---SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDW 303 ++FP F+ +++++L +R +I + F D+ Sbjct: 236 TLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMER-----PEAINIIENAVFEDLDF 288 >4IDT-A nrPDB Length = 356 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 113/279 (40%), Gaps = 22/279 (7%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 LG GSFG V ++ K+TG A+K + + E + P +V L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE--------ELMACAGLTSPRIVPLYG 133 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 169 + ++ + + ME + GG + ++ G E A +Y Q + EYLHS +++ D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 193 Query: 170 PENLLIDQQG-YIQVTDFGFAKRVKGR--------TWTLCGTPEYLAPEIILSKGYNKAV 220 +N+L+ G + + DFG A ++ + GT ++APE++L + + V Sbjct: 194 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKV 253 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV---RFPSHFSSDLKDLLRNLLQVD 277 D W+ ++ M G P+ + KI S P + ++ L+ + Sbjct: 254 DVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKE 313 Query: 278 LTKRFGNLKNG--VNDIKNHKWFATTDWIAIYQRKVEAP 314 R + G VN + W Y+ P Sbjct: 314 PIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPP 352 >4NEU-A nrPDB Length = 333 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 111/275 (40%), Gaps = 28/275 (10%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 L +G FG+V L H+ G MK + K ++ E L E +++ + +VKL Sbjct: 31 ELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNC-IEHNEALLEEAKMMNRLRHSRVVKLL 88 Query: 109 YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 + +VMEY+ G + L+ +I+ YLH +I++DL Sbjct: 89 GVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDL 148 Query: 169 KPENLLIDQQGYIQVTDFGFA----------------KRVKGRTWTLCGTPEYLAPEIIL 212 KPEN+L+D +I++ D G A + V G GT Y+APE + Sbjct: 149 KPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLN 208 Query: 213 S--KGYNKAVDWWALGVLIYEMAAGYPPFF-ADQPIQIYEKIVSGKV----RFPSHFSSD 265 + D ++ V+++ + A P+ A Q+ I SG + + Sbjct: 209 DVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPRE 268 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 + L++ + + R G+ + K ++ + Sbjct: 269 IISLMKLCWEANPEARPT--FPGIEE-KFRPFYLS 300 >3ZZW-A nrPDB Length = 289 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 55/276 (19%), Positives = 102/276 (36%), Gaps = 35/276 (12%) Query: 45 ERIKTLGTGSFGRVMLVK--HKETGNH---FAMKILDKQKVVKLKQIEHTLNEKRILQAV 99 ++ LG FG+V G A+K L + L+ E +E + + Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLR--EEFRHEAMLRARL 69 Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR----------------FSEPH 143 P +V L + L M+ Y G++ L P Sbjct: 70 QHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPD 129 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-LCGT 202 AQI EYL S ++++DL N+L+ + ++++D G + V + L G Sbjct: 130 FVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGN 189 Query: 203 ----PEYLAPEIILSKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGK-V 256 ++APE I+ ++ D W+ GV+++E + G P+ + E I + + + Sbjct: 190 SLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVL 249 Query: 257 RFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 P + + L+ ++R DI Sbjct: 250 PCPDDCPAWVYALMIECWNEFPSRR-----PRFKDI 280 >3LMG-A nrPDB Length = 344 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 55/281 (19%), Positives = 116/281 (41%), Gaps = 20/281 (7%) Query: 26 DFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH----FAMKILDKQKVV 81 D +K + ++K LG+G FG V G +K+++ + Sbjct: 15 DPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGR 74 Query: 82 KLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFS 140 + + + + +++ +V+L S+L +V +Y+P G + H+R+ G Sbjct: 75 QS--FQAVTDHMLAIGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQHRGALG 131 Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT---- 196 + QI YL +++R+L N+L+ +QV DFG A + Sbjct: 132 PQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLL 191 Query: 197 WTLCGTP-EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG 254 ++ TP +++A E I Y D W+ GV ++E+ G P+ + ++ + + G Sbjct: 192 YSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKG 251 Query: 255 -KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKN 294 ++ P + D+ ++ +D N++ ++ N Sbjct: 252 ERLAQPQICTIDVYMVMVKCWMID-----ENIRPTFKELAN 287 >3NIE-A nrPDB Length = 429 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 64/371 (17%), Positives = 135/371 (36%), Gaps = 76/371 (20%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D +E +G GS+G V L K + A+K +++ L + L E IL + Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRM-FEDLIDCKRILREITILNRLKS 86 Query: 102 PFLVKLEYSF-----KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 ++++L LY+V+E + ++ + +E H + ++L + Sbjct: 87 DYIIRLHDLIIPEDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEQHVKTILYNLLLGEK 145 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT-------------------- 196 ++H +I+RDLKP N L++Q +++ DFG A+ + Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 197 --------WTLCGTPEYLAPEII-LSKGYNKAVDWWALGVLIYEMA-----------AGY 236 + T Y APE+I L + Y ++D W+ G + E+ + Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 237 PPFFA---------DQPIQIYEK--------IVSGKVRFPSH-----FSSDLKDLLRNLL 274 P F +++EK I + P ++ ++ Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFP 325 Query: 275 QV---DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 331 DL+K++ ++ D+ + + P++ + N +++ Sbjct: 326 TRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE----NLENF 381 Query: 332 EEEEIRVSINE 342 E+I + ++ Sbjct: 382 STEKIILPFDD 392 >6CTH-A nrPDB Length = 309 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 51/202 (25%), Positives = 92/202 (45%), Gaps = 11/202 (5%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 F LG G FG V +++ + A+K + + + I+ +E +I+ + Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSR---ASKQGIKEYASEVKIISRLRHK 72 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF-YAAQIVLTFEYLHSL 161 LVKL + L +V E++ G + SH+ + R+ + YLH Sbjct: 73 NLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEE 132 Query: 162 D---LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSK 214 +++RD+K N+++D ++ DFG A+ V + L GT Y+APE + S Sbjct: 133 GDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSG 192 Query: 215 GYNKAVDWWALGVLIYEMAAGY 236 +K D ++ GV+ E+A+G Sbjct: 193 KASKESDVYSFGVVALEIASGR 214 >4Y83-A nrPDB Length = 332 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 103/255 (40%), Gaps = 24/255 (9%) Query: 52 TGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF 111 G+FG+V L + +T A K++ + I + +L + Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD--------VEIQACFRHENIAELYGAV 134 Query: 112 KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPE 171 +++ ME GG + L G E + ++ ++LHS +I+ D+KP Sbjct: 135 LWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 194 Query: 172 NLLIDQQGYIQVTDFGFAKRVKGRTW---TLCGTPEYLAPEIILSKGYNKAVDWWALGVL 228 N++ + + DFG + ++ + L GT Y++PE+IL +G++ D ++LG Sbjct: 195 NIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 253 Query: 229 IYEMAAGYPPF---FADQPIQIYEKIVSGKVRFPSH----FSSDLKDLLRNLLQVDLTKR 281 + M G PP+ + Y I+ + S +++L+ L+ + R Sbjct: 254 LIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 313 Query: 282 FGNLKNGVNDIKNHK 296 D+ H+ Sbjct: 314 -----PRAADLLKHE 323 >3PG1-A nrPDB Length = 362 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 117/310 (37%), Gaps = 28/310 (9%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKIL-----DKQKVVKLKQ---IEHTLNEKRI 95 + + + +GS+G V E G A+K + D + V L + L E R+ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 96 LQAVNFPFLVKLEYSFKDNSN-----LYMVMEYVPGGEMFSHLR-RIGRFSEPHARFYAA 149 L + P ++ L F LY+V E + ++ + + S H +++ Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQRIVISPQHIQYFMY 141 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR-VKGRTWTLCGT-PEYLA 207 I+L LH +++RDL P N+L+ I + DF A+ T T Y A Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRA 201 Query: 208 PEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS--GKVRFPSHF-- 262 PE+++ KG+ K VD W+ G ++ EM F KIV G + Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMF 261 Query: 263 -SSDLKDLLRNLLQVDLTKRFGNLKNGVN----DIKNHKWFATTDWIAIYQRKVEAPFIP 317 S +D LRN L + + + + D+ ++ + P+ Sbjct: 262 SSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFE 321 Query: 318 KFKGPGDTSN 327 P D + Sbjct: 322 SLFDPLDLTE 331 >5UIU-A nrPDB Length = 323 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 95/257 (36%), Gaps = 27/257 (10%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI-EHTLNEKRILQAVNFPFLVKL 107 +G G FG V T A+K L + +++ + E +++ LV+L Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRRIG---RFSEPHARFYAAQIVLTFEYLHSLDLI 164 D +L +V Y+P G + L + S A +LH I Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 165 YRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL-----CGTPEYLAPEIILSKGYNKA 219 +RD+K N+L+D+ +++DFG A+ + T+ GT Y+APE + + Sbjct: 172 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-TPK 230 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIY---------------EKIVSGKVRFPSHFSS 264 D ++ GV++ E+ G P + Q+ + I S Sbjct: 231 SDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVE 290 Query: 265 DLKDLLRNLLQVDLTKR 281 + + L KR Sbjct: 291 AMYSVASQCLHEKKNKR 307 >6FYV-A nrPDB Length = 337 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 75/329 (22%), Positives = 130/329 (39%), Gaps = 82/329 (24%) Query: 43 QFERIKTLGTGSFGRVMLVKHKE-TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++E + TLG G+FG+V+ G H A+KI+ + E +E ++L+ +N Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYR----EAARSEIQVLEHLNS 70 Query: 102 --PF----LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVL 153 P V++ F + ++ +V E + G + ++ F H R A QI Sbjct: 71 TDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQ 129 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQ-------------------QGYIQVTDFGFAKRVKG 194 + +LH L + DLKPEN+L + I+V DFG A Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDE 189 Query: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ---IYEKI 251 TL T Y APE+IL+ G+++ D W++G ++ E G+ F + + E+I Sbjct: 190 HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERI 249 Query: 252 VS------------------GKVRFPSHFS-----------------------SDLKDLL 270 + ++ + H S L DL+ Sbjct: 250 LGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLV 309 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWFA 299 R +L+ D T+R +++ H +F Sbjct: 310 RRMLEYDPTQRI-----TLDEALQHPFFD 333 >2A1A-B nrPDB Length = 284 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 64/262 (24%), Positives = 107/262 (40%), Gaps = 37/262 (14%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 F+ I+ +G+G FG+V KH+ G + +K + E E + L ++ Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-------EKAEREVKALAKLDHV 64 Query: 103 FLVKLEYSF----------------KDNSNLYMVMEYVPGGEMFSHL--RRIGRFSEPHA 144 +V + L++ ME+ G + + RR + + A Sbjct: 65 NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 124 Query: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGT 202 QI +Y+HS LI RDLKP N+ + +++ DFG +K G+ GT Sbjct: 125 LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGT 184 Query: 203 PEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI---YEKIVSGKVRFP 259 Y++PE I S+ Y K VD +ALG+++ E+ D + + + G + Sbjct: 185 LRYMSPEQISSQDYGKEVDLYALGLILAELL-----HVCDTAFETSKFFTDLRDGIIS-- 237 Query: 260 SHFSSDLKDLLRNLLQVDLTKR 281 F K LL+ LL R Sbjct: 238 DIFDKKEKTLLQKLLSKKPEDR 259 >3EB0-A nrPDB Length = 383 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 81/367 (22%), Positives = 135/367 (36%), Gaps = 89/367 (24%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 ++ KTLGTGSFG V V E+G FA+K + + K E I++ ++ Sbjct: 7 KKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN-------RELDIMKVLDH 59 Query: 102 PFLVKLEYSFKD--------------------------------------NSNLYMVMEY 123 ++KL F N L ++MEY Sbjct: 60 VNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEY 119 Query: 124 VP---GGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQG 179 VP + S +R Y Q+ ++HSL + +RD+KP+NLL++ + Sbjct: 120 VPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDN 179 Query: 180 YIQVTDFGFAKRVKGRTWTLCG--TPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGY 236 +++ DFG AK++ ++ + Y APE++L Y ++D W++G + E+ G Sbjct: 180 TLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK 239 Query: 237 PPFFADQPIQIYEKIVS-----------------GKVRF------------PSHFSSDLK 267 P F + I +I+ +VRF P S Sbjct: 240 PLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAI 299 Query: 268 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT--DWIAIYQRKVEAPFIPKFKGPGDT 325 DLL +L+ + R + H +F + + + P P Sbjct: 300 DLLEQILRYEPDLRINP-----YEAMAHPFFDHLRNSYESEVKNNSNFPHGVNQNIPQ-L 353 Query: 326 SNFDDYE 332 NF YE Sbjct: 354 FNFSPYE 360 >4C59-A nrPDB Length = 340 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 67/275 (24%), Positives = 112/275 (40%), Gaps = 42/275 (15%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-F 101 + + L G F V + +G +A+K L + K + I + E ++ ++ Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAI---IQEVCFMKKLSGH 84 Query: 102 PFLVKL--------EYSFKDNSNLYMVMEYVPGGEMFSHLRR---IGRFSEPHARFYAAQ 150 P +V+ E S + ++ E G++ L++ G S Q Sbjct: 85 PNIVQFCSAASIGKEESDTGQAEFLLLTELCK-GQLVEFLKKMESRGPLSCDTVLKIFYQ 143 Query: 151 IVLTFEYLHSLD--LIYRDLKPENLLIDQQGYIQVTDFGFA---------------KRVK 193 +++H +I+RDLK ENLL+ QG I++ DFG A + + Sbjct: 144 TCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALV 203 Query: 194 GRTWTLCGTPEYLAPEII-LSKGY--NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250 T TP Y PEII L + + D WALG ++Y + PF + + Sbjct: 204 EEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL----R 259 Query: 251 IVSGKVRFPSHFSS--DLKDLLRNLLQVDLTKRFG 283 IV+GK P H + L+R +LQV+ +R Sbjct: 260 IVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLS 294 >5TOS-A nrPDB Length = 395 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 63/280 (22%), Positives = 109/280 (38%), Gaps = 43/280 (15%) Query: 43 QFERIKTLGTGSFGRVMLV---------KHKETGNHFAMKILDKQKVVKLKQIEHTLNEK 93 F +G G FG V TG A+K L+++ + L E Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG---FQGHREWLTEI 122 Query: 94 RILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY----AA 149 L ++ P LVKL ++ + +V E++ G + +HL R G + +P F A Sbjct: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 Query: 150 QIVLTFEYLHS--LDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----RVKGRTWTLCGT 202 +LHS + +IYRD+K N+L+D +++DFG A+ + + + GT Sbjct: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 Query: 203 PEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP----------------IQ 246 Y APE + S N D ++ GVL+ E+ +G ++P + Sbjct: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 Query: 247 IYEKIVSGKVRFPSHFSSDL---KDLLRNLLQVDLTKRFG 283 IV ++ + + + L + R Sbjct: 303 KVLLIVDNRLDT-QYLPEEAVRMASVAVQCLSFEPKSRPT 341 >4G3E-A nrPDB Length = 352 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 50/199 (25%), Positives = 95/199 (47%), Gaps = 17/199 (8%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 +G GSFG V +K K+TG A+K + + + E ++ P +V L Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR--------VEELVACAGLSSPRIVPLYG 133 Query: 110 SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 169 + ++ + + ME + GG + ++++G E A +Y Q + EYLH+ +++ D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVK 193 Query: 170 PENLLIDQQG-YIQVTDFGFAKRVKGR--------TWTLCGTPEYLAPEIILSKGYNKAV 220 +N+L+ G + DFG A ++ + GT ++APE+++ K + V Sbjct: 194 ADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKV 253 Query: 221 DWWALGVLIYEMAAGYPPF 239 D W+ ++ M G P+ Sbjct: 254 DIWSSCCMMLHMLNGCHPW 272 >3UIU-A nrPDB Length = 306 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 63/275 (22%), Positives = 108/275 (39%), Gaps = 50/275 (18%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 F+ I+ +G+G FG+V KH+ G + ++ + E E + L ++ Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNN-------EKAEREVKALAKLDHV 65 Query: 103 FLVKLEYSF-----------------------------KDNSNLYMVMEYVPGGEMFSHL 133 +V + L++ ME+ G + + Sbjct: 66 NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWI 125 Query: 134 --RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191 RR + + A QI +Y+HS LI+RDLKP N+ + +++ DFG Sbjct: 126 EKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS 185 Query: 192 VK--GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI-- 247 +K G+ GT Y++PE I S+ Y K VD +ALG+++ E+ D + Sbjct: 186 LKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL-----HVCDTAFETSK 240 Query: 248 -YEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKR 281 + + G + F K LL+ LL R Sbjct: 241 FFTDLRDGIIS--DIFDKKEKTLLQKLLSKKPEDR 273 >6J5U-C nrPDB Length = 426 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 43/278 (15%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKET---------GNHFAMKILDKQKVVKLKQIEHTLNE 92 F + LG G FG V +T G A+K L + K+ L E Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKE---WLTE 140 Query: 93 KRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY--AAQ 150 L ++ P LV L + N +V E++P G + +HL R G A A Sbjct: 141 VNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVG 200 Query: 151 IVLTFEYLHSLD--LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC-----GTP 203 +LH +IYRD K N+L+D +++DFG AK T GT Sbjct: 201 AAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYP------------------PFFADQPI 245 Y APE + + D ++ GV++ E+ +G P+ D Sbjct: 261 GYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGD--K 318 Query: 246 QIYEKIVSGKV--RFPSHFSSDLKDLLRNLLQVDLTKR 281 + +I+ K+ ++P + +L L D R Sbjct: 319 RKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLR 356 >2WTK-B nrPDB Length = 373 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 57/348 (16%), Positives = 121/348 (34%), Gaps = 71/348 (20%) Query: 44 FERIKTLGTGSF---GRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +E + +G G F V L ++K TG + ++ ++ + + + E + + N Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEAC-SNEMVTFLQGELHVSKLFN 68 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI--GRFSEPHARFYAAQIVLTFEYL 158 P +V +F ++ L++V ++ G + +E + ++ +Y+ Sbjct: 69 HPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYI 128 Query: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDF--GFA--------KRVKGRTWTLCGTPEYLAP 208 H + ++R +K ++LI G + ++ + + V +L+P Sbjct: 129 HHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSP 188 Query: 209 EIILS--KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF-------- 258 E++ +GY+ D +++G+ E+A G+ PF Q+ + ++G V Sbjct: 189 EVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIP 248 Query: 259 ---------------------------------PSH-----FSSDLKDLLRNLLQVDLTK 280 PSH FS + LQ + Sbjct: 249 AEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDA 308 Query: 281 RFGNLKNGVNDIKNHKWFATTDWIAIYQ-RKVEAPFIPKFKGPGDTSN 327 R + + NH +F A ++ P P G S Sbjct: 309 R-----PSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQ 351 >4LQP-A nrPDB Length = 508 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 64/185 (34%), Positives = 106/185 (57%) Query: 14 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMK 73 E K + ++ + L+ F +K +G G+FG V LV+ K+TG +AMK Sbjct: 74 EERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMK 133 Query: 74 ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL 133 L K ++ K Q+ H E+ +L + P++V L YSF+D LY++ME++PGG++ + L Sbjct: 134 TLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTML 193 Query: 134 RRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK 193 R F+E RFY A+ +L E +H L I+R +KP+N+LID +G+I+++DFG + Sbjct: 194 IRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFH 253 Query: 194 GRTWT 198 + Sbjct: 254 KTHDS 258 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 59/149 (39%), Positives = 86/149 (57%), Gaps = 8/149 (5%) Query: 197 WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV--SG 254 ++ GTP+Y+APEI L +GY + DWW+LG ++YE G+PPF ++ P + Y KI+ Sbjct: 321 YSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQ 380 Query: 255 KVRFPS--HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 312 ++FP H S + +DL+R LL +R G G ++IK+H +F DW I R+VE Sbjct: 381 TLQFPDDIHISYEAEDLIRRLLTH-ADQRLGRH-GGADEIKSHPFFRGVDWNTI--RQVE 436 Query: 313 APFIPKFKGPGDTSNFDDYEEEEIRVSIN 341 AP+IPK DT F E E + S Sbjct: 437 APYIPKLSSITDTRFFPTDELENVPDSPA 465 >2CHL-A nrPDB Length = 351 Score = 181 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 76/322 (23%), Positives = 131/322 (40%), Gaps = 38/322 (11%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 F K +G G+FG + L K+ T + A+K+ + +E+ K++ P Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY-KQLGSGDGIP 89 Query: 103 FLVKLEYSFKDNSNLYMVMEYV--PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 ++ Y MV+E + ++F R FS A Q++ EY+HS Sbjct: 90 ---QVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FSLKTVLMIAIQLISRMEYVHS 144 Query: 161 LDLIYRDLKPENLLIDQQG-----YIQVTDFGFAKRVKG----------RTWTLCGTPEY 205 +LIYRD+KPEN LI + G I + DF AK +L GT Y Sbjct: 145 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARY 204 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFPSHF 262 ++ L K ++ D ALG + G P+ D + Y+KI K P Sbjct: 205 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 264 Query: 263 ----SSDLKDLLRNLLQVDLTKR--FGNLKNGVNDI---KNHKWFATTDWIAIYQRKVEA 313 ++ LR + ++D ++ + L+ D+ K + + DWI +++ Sbjct: 265 LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIG---KQLPT 321 Query: 314 PFIPKFKGPGDTSNFDDYEEEE 335 P + P +SN + ++ + Sbjct: 322 PVGAVQQDPALSSNREAHQHRD 343 >2H34-A nrPDB Length = 309 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 54/260 (20%), Positives = 95/260 (36%), Gaps = 7/260 (2%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 ++ + + +G G G V + A+K++ + E R Sbjct: 27 SREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREAR 86 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 + P +V + + + LY+ M + G ++ + LRR G + P A QI Sbjct: 87 TAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSA 146 Query: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT----LCGTPEYLAPEI 210 + H+ +RD+KPEN+L+ + + DFG A T GT Y+APE Sbjct: 147 LDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER 206 Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP---SHFSSDLK 267 D +AL ++YE G PP+ DQ + I R Sbjct: 207 FSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFD 266 Query: 268 DLLRNLLQVDLTKRFGNLKN 287 ++ + + R+ + Sbjct: 267 AVIARGMAKNPEDRYVTCGD 286 >4JLC-A nrPDB Length = 657 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 59/230 (25%), Positives = 110/230 (47%), Gaps = 25/230 (10%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 LG G+ V +HK+TG+ +A+K+ + ++ ++ + E +L+ +N +VKL Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 72 Query: 109 YSFKDNSNLY--MVMEYVPGGEMFSHLRRIGR---FSEPHARFYAAQIVLTFEYLHSLDL 163 ++ + + ++ME+ P G +++ L E +V +L + Sbjct: 73 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 132 Query: 164 IYRDLKPENLL--IDQQGY--IQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIIL----- 212 ++RD+KP N++ I + G ++TDFG A+ ++ +L GT EYL P++ Sbjct: 133 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 192 Query: 213 ---SKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQIYEKIVSGK 255 K Y VD W++GV Y A G PF + ++ KI++GK Sbjct: 193 KDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 242 >4EUU-A nrPDB Length = 319 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 59/230 (25%), Positives = 110/230 (47%), Gaps = 25/230 (10%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 LG G+ V +HK+TG+ FA+K+ + ++ ++ + E +L+ +N +VKL Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 73 Query: 109 YSFKDNSNLY--MVMEYVPGGEMFSHLRRIGR---FSEPHARFYAAQIVLTFEYLHSLDL 163 ++ + + ++ME+ P G +++ L E +V +L + Sbjct: 74 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 164 IYRDLKPENLL--IDQQGY--IQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIIL----- 212 ++R++KP N++ I + G ++TDFG A+ ++ +L GT EYL P++ Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 213 ---SKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQIYEKIVSGK 255 K Y VD W++GV Y A G PF + ++ KI++GK Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 243 >5WNL-A nrPDB Length = 342 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 115/281 (40%), Gaps = 27/281 (9%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT 89 +W T +F + +G+G FG+V V+H A+K V +++E Sbjct: 8 RWALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERME-L 66 Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149 L E + ++ F +++ + ++ + +VMEY+ G + L Sbjct: 67 LEEAKKMEMAKFRYILPVYGICQE--PVGLVMEYMETGSLEKLLAS-EPLPWDLRFRIVH 123 Query: 150 QIVLTFEYLH--SLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWT---LCG 201 + + +LH S L++ +LKP N+L+D +++++DFG AK + L G Sbjct: 124 ETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFG 183 Query: 202 TPEYLAPEIILSKG--YNKAVDWWALGVLIYEMAAGYPPFFADQP-IQIYEKIVSG-KVR 257 T YL PE I K ++ D ++ ++I+ + PF ++ + I K+V G + Sbjct: 184 TIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPE 243 Query: 258 FPSHFSS------DLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 P L L++ D R +I Sbjct: 244 LPPICRPRPRACASLIGLMQRCWHADPQVR-----PTFQEI 279 >4EUT-A nrPDB Length = 396 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 59/230 (25%), Positives = 110/230 (47%), Gaps = 25/230 (10%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 LG G+ V +HK+TG+ FA+K+ + ++ ++ + E +L+ +N +VKL Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 73 Query: 109 YSFKDNSNLY--MVMEYVPGGEMFSHLRRIGR---FSEPHARFYAAQIVLTFEYLHSLDL 163 ++ + + ++ME+ P G +++ L E +V +L + Sbjct: 74 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 164 IYRDLKPENLL--IDQQGY--IQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIIL----- 212 ++R++KP N++ I + G ++TDFG A+ ++ +L GT EYL P++ Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 213 ---SKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQIYEKIVSGK 255 K Y VD W++GV Y A G PF + ++ KI++GK Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 243 >5UNP-A nrPDB Length = 369 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 75/332 (22%), Positives = 130/332 (39%), Gaps = 82/332 (24%) Query: 42 DQFERIKTLGTGSFGRVMLVK-HKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +++E + TLG G+FGRV+ H+ G A+KI+ + K E E +L+ +N Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYK----EAARLEINVLEKIN 89 Query: 101 -----FPFL-VKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP--HARFYAAQIV 152 L V++ F + ++ + E + G F L+ P R A Q+ Sbjct: 90 EKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLC 148 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGY-------------------IQVTDFGFAKRVK 193 ++LH L + DLKPEN+L Y ++V DFG A Sbjct: 149 QAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDH 208 Query: 194 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ---IYEK 250 T+ T Y APE+IL G+++ D W++G +I+E G+ F + + E+ Sbjct: 209 EHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMER 268 Query: 251 IV------------------SGKVRFPSHFSS-----------------------DLKDL 269 I+ G++ + + S+ L DL Sbjct: 269 ILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDL 328 Query: 270 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 + ++L+ + KR + + H +FA Sbjct: 329 IESMLEYEPAKRL-----TLGEALQHPFFARL 355 >5TE0-A nrPDB Length = 347 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 63/262 (24%), Positives = 108/262 (41%), Gaps = 38/262 (14%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-FPFLVK 106 + L G F V LV+ G A+K + V ++ E +I++ ++ +V Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMF---VNNEHDLQVCKREIQIMRDLSGHKNIVG 80 Query: 107 LEYSFKDN---SNLY---MVMEYVPGGEMFSHLRRI--GRFSEPHARFYAAQIVLTFEYL 158 S +N +++ ++M++ GG++ + + + F+E L Sbjct: 81 YIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARL 140 Query: 159 HSLD--LIYRDLKPENLLIDQQGYIQVTDFGFAK------------RVKGRTWTLCGTPE 204 H +I+RDLK EN+L+ +G+ + DFG A V+ T Sbjct: 141 HQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT-TLS 199 Query: 205 YLAPEIIL---SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH 261 Y APE++ K D WALG L+Y++ PF Q I G P + Sbjct: 200 YRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA-----ICDGNFTIPDN 254 Query: 262 --FSSDLKDLLRNLLQVDLTKR 281 +S D+ L+R +L+ D KR Sbjct: 255 SRYSQDMHCLIRYMLEPDPDKR 276 >5LPZ-A nrPDB Length = 332 Score = 176 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 57/240 (23%), Positives = 97/240 (40%), Gaps = 23/240 (9%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F +G+G FG V K+ G+ A+K L ++ + E + + Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDRE---FMAEMETIGKIKHRN 74 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR----FSEPHARFYAAQIVLTFEYLH 159 LV L K +V E++ G + L + + R A +LH Sbjct: 75 LVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 160 ---SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW-----TLCGTPEYLAPEII 211 S +I+RD+K N+L+D+ +V+DFG A+ + TL GTP Y+ PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY 194 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPP-----FFADQPIQIYEKIVSGKVRFPSHFSSDL 266 S + D ++ GV++ E+ G P F + + ++ K+R F +L Sbjct: 195 QSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQ--HAKLRISDVFDPEL 252 >3HNG-A nrPDB Length = 360 Score = 176 bits (448), Expect = 9e-45, Method: Composition-based stats. Identities = 71/347 (20%), Positives = 129/347 (37%), Gaps = 88/347 (25%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV-----KHKETGNHFAMKILDKQKVVK- 82 KWE ++ + K+LG G+FG+V+ K T A+K+L + Sbjct: 20 SKWEFAR------ERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASE 73 Query: 83 ----------LKQIEHTLNEKRILQAV---NFPFLVKLEYS--------FKDNSNLYMV- 120 L I H LN +L A P +V +EY K +L+ + Sbjct: 74 YKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLN 133 Query: 121 -------------ME-------------------YVPGG-----EMFSHLRRIG------ 137 ME + G + Sbjct: 134 KDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYK 193 Query: 138 -RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGR 195 + Y+ Q+ E+L S I+RDL N+L+ + +++ DFG A+ + K Sbjct: 194 EPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNP 253 Query: 196 TWTLCG----TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIY-E 249 + G +++APE I K Y+ D W+ GVL++E+ + G P+ Q + + Sbjct: 254 DYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCS 313 Query: 250 KIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTK--RFGNLKNGVNDIK 293 ++ G ++R P + + ++ ++ + D + RF L + D+ Sbjct: 314 RLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 360 >5LPV-A nrPDB Length = 296 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 57/240 (23%), Positives = 97/240 (40%), Gaps = 23/240 (9%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 F +G+G FG V K+ G+ A+K L ++ + E + + Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDRE---FMAEMETIGKIKHRN 74 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR----FSEPHARFYAAQIVLTFEYLH 159 LV L K +V E++ G + L + + R A +LH Sbjct: 75 LVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 160 ---SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW-----TLCGTPEYLAPEII 211 S +I+RD+K N+L+D+ +V+DFG A+ + TL GTP Y+ PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY 194 Query: 212 LSKGYNKAVDWWALGVLIYEMAAGYPP-----FFADQPIQIYEKIVSGKVRFPSHFSSDL 266 S + D ++ GV++ E+ G P F + + ++ K+R F +L Sbjct: 195 QSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQ--HAKLRISDVFDPEL 252 >6NT9-A nrPDB Length = 742 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 59/230 (25%), Positives = 110/230 (47%), Gaps = 25/230 (10%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 LG G+ V +HK+TG+ FA+K+ + ++ ++ + E +L+ +N +VKL Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 71 Query: 109 YSFKDNSNLY--MVMEYVPGGEMFSHLRRIGR---FSEPHARFYAAQIVLTFEYLHSLDL 163 ++ + + ++ME+ P G +++ L E +V +L + Sbjct: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 Query: 164 IYRDLKPENLL--IDQQGY--IQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIIL----- 212 ++R++KP N++ I + G ++TDFG A+ ++ +L GT EYL P++ Sbjct: 132 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 Query: 213 ---SKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQIYEKIVSGK 255 K Y VD W++GV Y A G PF + ++ KI++GK Sbjct: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241 >6O8B-A nrPDB Length = 665 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 59/230 (25%), Positives = 109/230 (47%), Gaps = 25/230 (10%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 108 LG G+ V +HK+TG+ FA+K+ + ++ ++ + E +L+ +N +VKL Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 79 Query: 109 YSFKDNSNLY--MVMEYVPGGEMFSHLRRIGR---FSEPHARFYAAQIVLTFEYLHSLDL 163 ++ + + ++ME+ P G +++ L E +V +L + Sbjct: 80 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 139 Query: 164 IYRDLKPENLL--IDQQGY--IQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIIL----- 212 ++R++KP N++ I + G ++TDFG A+ ++ L GT EYL P++ Sbjct: 140 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLR 199 Query: 213 ---SKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQIYEKIVSGK 255 K Y VD W++GV Y A G PF + ++ KI++GK Sbjct: 200 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 249 >2Y4I-B nrPDB Length = 319 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 68/325 (20%), Positives = 129/325 (39%), Gaps = 49/325 (15%) Query: 15 SVKEFLAKAKED--FLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAM 72 S + F KA + FL++W+ P +Q E + +G G FG+V + A+ Sbjct: 10 SARSFPRKASQTSIFLQEWDIP------FEQLEIGELIGKGRFGQVYHGRWHG---EVAI 60 Query: 73 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSH 132 +++D ++ + Q++ E + +V + +L ++ G ++S Sbjct: 61 RLIDIERDNED-QLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSV 119 Query: 133 LRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF--- 188 +R R A +IV YLH+ ++++DLK +N+ D G + +TDFG Sbjct: 120 VRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSI 178 Query: 189 -----AKRVKGRTWTLCGTPEYLAPEIILS---------KGYNKAVDWWALGVLIYEMAA 234 A R + + G +LAPEII ++K D +ALG + YE+ A Sbjct: 179 SGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA 238 Query: 235 GYPPFFADQPIQIYEKIVSGKVRFPSHFSS-----DLKDLLRNLLQVDLTKRFGNLKNGV 289 PF I ++ +G + S ++ D+L + +R Sbjct: 239 REWPFKTQPAEAIIWQMGTG---MKPNLSQIGMGKEISDILLFCWAFEQEER-----PTF 290 Query: 290 NDIKNHKWFATTDWIAIYQRKVEAP 314 + + + + R++ P Sbjct: 291 TKLMDM-----LEKLPKRNRRLSHP 310 >2BUJ-A nrPDB Length = 317 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 60/268 (22%), Positives = 111/268 (41%), Gaps = 33/268 (12%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + I+ LG G F V LV+ G+ +A+K + + + E E + + N Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI---LCHEQQDREEAQREADMHRLFNH 85 Query: 102 PFLVKLEYSFKDNS----NLYMVMEYVPGGEMFSHLRRIGR----FSEPHARFYAAQIVL 153 P +++L ++++ + G +++ + R+ +E + I Sbjct: 86 PNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICR 145 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF----AKRVKGRTWTLC--------G 201 E +H+ +RDLKP N+L+ +G + D G V+G L Sbjct: 146 GLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRC 205 Query: 202 TPEYLAPEIILSKGY---NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI---VSGK 255 T Y APE+ + + ++ D W+LG ++Y M G P+ D Q + + V + Sbjct: 206 TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY--DMVFQKGDSVALAVQNQ 263 Query: 256 VRFP--SHFSSDLKDLLRNLLQVDLTKR 281 + P SS L LL +++ VD +R Sbjct: 264 LSIPQSPRHSSALWQLLNSMMTVDPHQR 291 >6O6Q-A nrPDB Length = 335 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 62/321 (19%), Positives = 124/321 (38%), Gaps = 65/321 (20%) Query: 25 EDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLK 84 +D KW + +E ++ LG G + V L E +K+L K K+K Sbjct: 31 DDLNIKW-------NPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIK 83 Query: 85 QIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLY--MVMEYVPGGEMFSHLRRIGRFSE 141 E IL+ + + P ++ + ++ + ++ E++ + S F++ Sbjct: 84 ------REISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL---YPTFTD 134 Query: 142 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVKG--RTWT 198 RFY +++ +Y HS+ +++RD+KP N++ID +++ D+G A+ Sbjct: 135 YDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNV 194 Query: 199 LCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFA-----DQPIQIYEKIV 252 + + PE+++ + Y+ ++D W+ G ++ M PFF DQ +QI + Sbjct: 195 RVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLG 254 Query: 253 SGKVRF--------------------------------PSHFSSDLKDLLRNLLQVDLTK 280 S + S + DL+ LL+ D + Sbjct: 255 SKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQE 314 Query: 281 RFGNLKNGVNDIKNHKWFATT 301 R + H +F Sbjct: 315 RL-----TAKEAMKHAYFDPI 330 >5VC6-A nrPDB Length = 289 Score = 173 bits (440), Expect = 7e-44, Method: Composition-based stats. Identities = 54/278 (19%), Positives = 112/278 (40%), Gaps = 33/278 (11%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + + + +F ++ +G+G FG V + G +A+K K+ + ++ L E Sbjct: 4 SMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR-SKKPLAGSVDEQNALREVY 62 Query: 95 ILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR----FSEPHARFYAA 149 + +V+ ++ ++ ++ + EY GG + + R F E + Sbjct: 63 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLL 122 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQG-------------------YIQVTDFGFAK 190 Q+ Y+HS+ L++ D+KP N+ I + ++ D G Sbjct: 123 QVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVT 182 Query: 191 RVKGRTWTLCGTPEYLAPEIILSKGYNK--AVDWWALGVLIYEMAAGYPPFFADQPIQIY 248 R+ G +LA E++ + Y D +AL + + AAG P + + Sbjct: 183 RI-SSPQVEEGDSRFLANEVL-QENYTHLPKADIFALALTV-VCAAGAEPLP--RNGDQW 237 Query: 249 EKIVSGKV-RFPSHFSSDLKDLLRNLLQVDLTKRFGNL 285 +I G++ R P S + +LL+ ++ D +R + Sbjct: 238 HEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAM 275 >2PMN-X nrPDB Length = 348 Score = 173 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 58/323 (17%), Positives = 133/323 (41%), Gaps = 53/323 (16%) Query: 32 ENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQI----- 86 + + +++ + I+TL G F +++L + + +A+K +K + K + Sbjct: 21 KYVKEKDKYINDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNN 78 Query: 87 ---------EHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG 137 + NE +I+ + + + E + +Y++ EY+ + Sbjct: 79 DKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFF 138 Query: 138 RFSEPHARFYAAQIVLTF--------EYLH-SLDLIYRDLKPENLLIDQQGYIQVTDFGF 188 + + F Q++ Y+H ++ +RD+KP N+L+D+ G ++++DFG Sbjct: 139 VLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGE 198 Query: 189 AKRVKGRT-WTLCGTPEYLAPEIILSKGY--NKAVDWWALGVLIYEMAAGYPPFF-ADQP 244 ++ + + GT E++ PE ++ VD W+LG+ +Y M PF Sbjct: 199 SEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISL 258 Query: 245 IQIYEKIVSGKVRFP-------------------SHFSSDLKDLLRNLLQVDLTKRFGNL 285 ++++ I + + +P + S++ D L+ L+ + +R + Sbjct: 259 VELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITS- 317 Query: 286 KNGVNDIKNHKWFATTDWIAIYQ 308 D H+W A T+ + + Sbjct: 318 ----EDALKHEWLADTNIEDLRE 336 >5AR8-A nrPDB Length = 326 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 114/281 (40%), Gaps = 25/281 (8%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 A T + ++ L G+ G V +H + A+K L + + + L E Sbjct: 25 ALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAE 84 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE---PHARFYAAQI 151 IL F +++ + + L +V EY+P G + L R + + P +I Sbjct: 85 ILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEI 144 Query: 152 VLTFEYLHSLD--LIYRDLKPENLLIDQQGYIQVTDFGFAK--------RVKGRTWTLCG 201 L YLH++ L++ DLK +N+L+D + ++++ DFG +K ++ G Sbjct: 145 ALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGG 204 Query: 202 TPEYLAPEIILSKGYNKAV---DWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIVSG--- 254 T Y+ PE ++A D ++ V+ +E+ + PF P+QI + G Sbjct: 205 TIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRP 264 Query: 255 ---KVRFPSHFSSDLK--DLLRNLLQVDLTKRFGNLKNGVN 290 + P + L+ + + +R LK + Sbjct: 265 VINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIE 305 >3Q4U-A nrPDB Length = 301 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 55/293 (18%), Positives = 107/293 (36%), Gaps = 58/293 (19%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ--AVN 100 ++ +G G +G V + G + A+KI + + E + + Sbjct: 9 DITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSS------RDEKSWFRETELYNTVMLR 60 Query: 101 FPFLVKLE----YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 ++ S ++ L+++ Y G ++ +L+ + R I Sbjct: 61 HENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLR-IVLSIASGLA 119 Query: 157 YLH--------SLDLIYRDLKPENLLIDQQGYIQVTDFGFA-------KRVKGRTWTLCG 201 +LH + +RDLK +N+L+ + G + D G A ++ G Sbjct: 120 HLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVG 179 Query: 202 TPEYLAPEIILSKGY------NKAVDWWALGVLIYEMAAG----------YPPFFA---- 241 T Y+APE++ K VD WA G++++E+A PPF+ Sbjct: 180 TKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPN 239 Query: 242 DQPIQIYEKIV---SGKVRFPSHFSSD-----LKDLLRNLLQVDLTKRFGNLK 286 D + K+V + P+ + SD L L++ + + R L+ Sbjct: 240 DPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALR 292 >3RAW-A nrPDB Length = 381 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 120/332 (36%), Gaps = 82/332 (24%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGN-HFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 +++E + LG G+FG+V+ G A+KI+ K E E +L+ + Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVG----KYREAARLEINVLKKIK 106 Query: 101 FP------FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI--GRFSEPHARFYAAQIV 152 V + F + ++ + E + G F L+ + PH R A Q+ Sbjct: 107 EKDKENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLC 165 Query: 153 LTFEYLHSLDLIYRDLKPENLLIDQ-------------------QGYIQVTDFGFAKRVK 193 +LH L + DLKPEN+L I+V DFG A Sbjct: 166 HALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH 225 Query: 194 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ---IYEK 250 T+ T Y PE+IL G+ + D W++G +++E G+ F + + + EK Sbjct: 226 EHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEK 285 Query: 251 IV------------------SGKVRFPSHFSS-----------------------DLKDL 269 I+ G + + + S L DL Sbjct: 286 ILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDL 345 Query: 270 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 +R +L+ D +R + + H +FA Sbjct: 346 MRRMLEFDPAQRI-----TLAEALLHPFFAGL 372 >5IKW-A nrPDB Length = 310 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 107/263 (40%), Gaps = 35/263 (13%) Query: 45 ERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-FPF 103 ++L G F V LV+ G A+K + V + + E I++ ++ Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMY---VNNMPDLNVCKREITIMKELSGHKN 72 Query: 104 LVKLEYSFKDN--SNLY---MVMEYVPGGEMFSHLRRI--GRFSEPHARFYAAQIVLTFE 156 +V ++ N++ ++MEY G++ + + + F+EP Sbjct: 73 IVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 132 Query: 157 YLHSLD--LIYRDLKPENLLIDQQGYIQVTDFGFA--KRVKGRTWTLCG---------TP 203 LH +I+RDLK EN+L++ G + DFG A K + + + T Sbjct: 133 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 192 Query: 204 EYLAPEIIL---SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS 260 Y APE+I K D WALG L+Y++ PF Q I G P Sbjct: 193 SYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA-----ICDGNFTIPD 247 Query: 261 H--FSSDLKDLLRNLLQVDLTKR 281 + +S ++ L+R +L+ D R Sbjct: 248 NSRYSRNIHCLIRFMLEPDPEHR 270 >5CEK-A nrPDB Length = 263 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 62/252 (24%), Positives = 107/252 (42%), Gaps = 23/252 (9%) Query: 58 VMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR-ILQAVNFPFLVKLEYSFKDNSN 116 V TG K+ I+H ++ R +Q + + + + Sbjct: 25 VSRALCIHTGRELRCKVFP---------IKHYQDKIRPYIQLPSHSNITGIVEVILGETK 75 Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI- 175 Y+ E G+M S++R R E A QIV + H ++ DLK + Sbjct: 76 AYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFS 134 Query: 176 -DQQGYIQVTDFGFAKRVKGRTWTLC---GTPEYLAPEIILSKG-YN-KAVDWWALGVLI 229 +++ +++ +KG L G P Y++PEI+ + G Y+ KA D W+LGV++ Sbjct: 135 TEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVML 194 Query: 230 YEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV 289 Y + G PF P ++ KI G+ P H S + L+R+LL+ + ++R Sbjct: 195 YTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-----TA 249 Query: 290 NDIKNHKWFATT 301 +I H WF + Sbjct: 250 PEILLHPWFESV 261 >6DC0-A nrPDB Length = 292 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 62/252 (24%), Positives = 107/252 (42%), Gaps = 23/252 (9%) Query: 58 VMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR-ILQAVNFPFLVKLEYSFKDNSN 116 V TG K+ I+H ++ R +Q + + + + Sbjct: 22 VSRALCIHTGRELRCKVFP---------IKHYQDKIRPYIQLPSHSNITGIVEVILGETK 72 Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI- 175 Y+ E G+M S++R R E A QIV + H ++ DLK + Sbjct: 73 AYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFS 131 Query: 176 -DQQGYIQVTDFGFAKRVKGRTWTLC---GTPEYLAPEIILSKG-YN-KAVDWWALGVLI 229 +++ +++ +KG L G P Y++PEI+ + G Y+ KA D W+LGV++ Sbjct: 132 TEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVML 191 Query: 230 YEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV 289 Y + G PF P ++ KI G+ P H S + L+R+LL+ + ++R Sbjct: 192 YTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-----TA 246 Query: 290 NDIKNHKWFATT 301 +I H WF + Sbjct: 247 PEILLHPWFESV 258 >5FQD-C nrPDB Length = 341 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 124/297 (41%), Gaps = 36/297 (12%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-VNF 101 +++ ++ +G+GSFG + L + G A+K+ ++ + Q+ + +ILQ V Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKA--RHPQLLYESKLYKILQGGVGI 77 Query: 102 PFLVKLEYSFKDNSNLYMVMEYV--PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 P + + ++ +VM+ + ++F+ R RF+ A Q++ EY+H Sbjct: 78 PHI---RWYGQEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMKTVLMLADQMISRIEYVH 132 Query: 160 SLDLIYRDLKPENLLIDQQGYIQ---VTDFGFAKRVKG----------RTWTLCGTPEYL 206 + + I+RD+KP+N L+ + + DFG AK+ + L GT Y Sbjct: 133 TKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYA 192 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFPSH-- 261 + L ++ D +LG ++ P+ Q YEKI K+ P Sbjct: 193 SINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVL 252 Query: 262 ---FSSDLKDLLRNL--LQVDLTKRFGNLKNGVNDI---KNHKWFATTDWIAIYQRK 310 F ++ L L+ + + L+ + NH++ T DW + Q+ Sbjct: 253 CKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKA 309 >3UIM-A nrPDB Length = 326 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 50/216 (23%), Positives = 87/216 (40%), Gaps = 14/216 (6%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 + D F LG G FG+V + G A+K L +++ + E Sbjct: 23 RELQVASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGEL--QFQTEVE 79 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG----RFSEPHARFYAAQ 150 ++ L++L + +V Y+ G + S LR P + A Sbjct: 80 MISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALG 139 Query: 151 IVLTFEYLHSL---DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC----GTP 203 YLH +I+RD+K N+L+D++ V DFG AK + + + GT Sbjct: 140 SARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTI 199 Query: 204 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 239 ++APE + + ++ D + GV++ E+ G F Sbjct: 200 GHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >5XD6-A nrPDB Length = 305 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 51/224 (22%), Positives = 84/224 (37%), Gaps = 23/224 (10%) Query: 33 NPAQNTAHL-DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLN 91 PA + D + +G GS+GRV K +G A+K LD K + L Sbjct: 12 IPADELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD----QEFLA 66 Query: 92 EKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR---------FSEP 142 + ++ + +V L D + EY P G + L S Sbjct: 67 QVSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWH 126 Query: 143 HARFYAAQIVLTFEYLHSL---DLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----- 194 A EYLH +I+RD+K N+L+ ++ DF + + Sbjct: 127 QRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARL 186 Query: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP 238 + + GT Y APE ++ + D ++ GV++ E+ G P Sbjct: 187 HSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >3MY0-A nrPDB Length = 305 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 56/302 (18%), Positives = 104/302 (34%), Gaps = 60/302 (19%) Query: 46 RIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA--VNFPF 103 ++ +G G +G V G A+KI + + E I + Sbjct: 12 LVECVGKGRYGEVWRG--LWHGESVAVKIFSS------RDEQSWFRETEIYNTVLLRHDN 63 Query: 104 LVKLE----YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 ++ S ++ L+++ Y G ++ L+R A A +LH Sbjct: 64 ILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT-LEPHLALRLAVSAACGLAHLH 122 Query: 160 --------SLDLIYRDLKPENLLIDQQGYIQVTDFGFA-KRVKGRTW------TLCGTPE 204 + +RD K N+L+ + D G A +G + GT Sbjct: 123 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR 182 Query: 205 YLAPEIILSKGYN------KAVDWWALGVLIYEMAAG----------YPPFFA----DQP 244 Y+APE++ + K D WA G++++E+A PPF+ D Sbjct: 183 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPS 242 Query: 245 IQIYEKIV---SGKVRFPSHFSSD-----LKDLLRNLLQVDLTKRFGNLK--NGVNDIKN 294 + +K+V P+ ++D L ++R + + R L+ + I N Sbjct: 243 FEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISN 302 Query: 295 HK 296 Sbjct: 303 SP 304 >4TN6-A nrPDB Length = 318 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 122/306 (39%), Gaps = 36/306 (11%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-VN 100 +++ + +G+GSFG + L G A+K+ + IE + +++Q V Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIY--KMMQGGVG 64 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYV--PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 P + + + MVME + ++F+ R +FS A Q++ EY+ Sbjct: 65 IPTI---RWCGAEGDYNVMVMELLGPSLEDLFNFCSR--KFSLKTVLLLADQMISRIEYI 119 Query: 159 HSLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKG----------RTWTLCGTPEY 205 HS + I+RD+KP+N L+ + + + DFG AK+ + L GT Y Sbjct: 120 HSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARY 179 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFPSHF 262 + L ++ D +LG ++ G P+ Q YE+I K+ P Sbjct: 180 ASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEV 239 Query: 263 -----SSDLKDLLRNL--LQVDLTKRFGNLKNGVNDIKNHKWFATT---DWIAIYQRKVE 312 S+ L L+ D + L+ ++ + + F+ DW + Sbjct: 240 LCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASR 299 Query: 313 APFIPK 318 A +P+ Sbjct: 300 AALVPR 305 >3MDY-A nrPDB Length = 337 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 112/294 (38%), Gaps = 58/294 (19%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-- 99 Q + +K +G G +G V + K + G A+K+ + E I Q V Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASW------FRETEIYQTVLM 88 Query: 100 NFPFLVKLEYSFKDNS----NLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 ++ + + LY++ +Y G ++ +L+ A V Sbjct: 89 RHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT-LDAKSMLKLAYSSVSGL 147 Query: 156 EYLHS--------LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT-------WTLC 200 +LH+ + +RDLK +N+L+ + G + D G A + T T Sbjct: 148 CHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRV 207 Query: 201 GTPEYLAPEII---LSKGYNKA---VDWWALGVLIYEMAAG----------YPPF----F 240 GT Y+ PE++ L++ + ++ D ++ G++++E+A P+ Sbjct: 208 GTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVP 267 Query: 241 ADQPIQIYEK---IVSGKVRFPSHFSSD-----LKDLLRNLLQVDLTKRFGNLK 286 +D + + I + FP+ +SSD + L+ + R L+ Sbjct: 268 SDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALR 321 >3SV0-A nrPDB Length = 483 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 70/342 (20%), Positives = 132/342 (38%), Gaps = 39/342 (11%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ-AVN 100 ++F + +G+GSFG + L + +T A+K+ + + K Q+ + RILQ Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVK--TKHPQLLYESKIYRILQGGTG 64 Query: 101 FPFLVKLEYSFKDNSNLYMVMEYV--PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 P V+ + +VM+ + ++F+ R + S A Q++ E++ Sbjct: 65 IPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSR--KLSLKTVLMLADQMINRVEFV 119 Query: 159 HSLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKG----------RTWTLCGTPEY 205 HS ++RD+KP+N L+ + + + DFG AK+ + L GT Y Sbjct: 120 HSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARY 179 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFPSH- 261 + L ++ D +LG ++ G P+ Q YEKI KV Sbjct: 180 ASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEA 239 Query: 262 ----FSSDLKDLLRNL--LQVDLTKRFGNLKNGVNDIKNHKWFA---TTDWIAIYQRKVE 312 + ++ L+ D + LK D+ + F DW + ++ + Sbjct: 240 LCRGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLFIREGFQFDYVFDWTILKYQQSQ 299 Query: 313 ---APFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351 AP G G + + + + ++E +S Sbjct: 300 IASAPPRAVGHGAGPSGLAPPALQNDRQSGVDEGRTSGWSSM 341 >2CMW-A nrPDB Length = 310 Score = 167 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 123/303 (40%), Gaps = 42/303 (13%) Query: 45 ERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF--P 102 K +G G+FG + L K+ T + A+K+ + + E R + + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHL-----EYRFYKQLGSAGE 57 Query: 103 FLVKLEYSFKDNSNLYMVMEYV--PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 L ++ Y MV+E + ++F R F+ A Q++ EY+HS Sbjct: 58 GLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FTLKTVLMIAIQLLSRMEYVHS 115 Query: 161 LDLIYRDLKPENLLIDQQG-----YIQVTDFGFAKRVKG----------RTWTLCGTPEY 205 +LIYRD+KPEN LI +QG I + DFG AK +L GT Y Sbjct: 116 KNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 175 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFP--- 259 ++ L K ++ D ALG + G P+ D + Y+KI K P Sbjct: 176 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEA 235 Query: 260 --SHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDI---KNHKWFATTDWIAIYQRKVE 312 +F ++ LR + ++D ++ + L+ D+ K + + DW+ R + Sbjct: 236 LCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVG---RPIP 292 Query: 313 APF 315 P Sbjct: 293 TPV 295 >5VDK-A nrPDB Length = 297 Score = 167 bits (423), Expect = 7e-42, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 111/275 (40%), Gaps = 37/275 (13%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ 97 + + +F ++ +G G FG V + G +A+K + +L L+E Sbjct: 11 SRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHA 69 Query: 98 AV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL----RRIGRFSEPHARFYAAQIV 152 + + P +V+ S+ ++ ++ + EY GG + + + + F EP + QI Sbjct: 70 VLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQIS 129 Query: 153 LTFEYLHSLDLIYRDLKPENLLI------DQQGYI-----------------QVTDFGFA 189 L Y+H+ +++ D+KP N+ I + G I ++ D G A Sbjct: 130 LGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHA 189 Query: 190 KRVKGRTWTLCGTPEYLAPEIILSKGYNK--AVDWWALGVLIYEMAAGYPPFFADQPIQI 247 + + G +LA E IL + Y D +ALG+ I +AAG Sbjct: 190 TSIN-KPKVEEGDSRFLANE-ILQEDYRHLPKADIFALGLTIA-VAAGAESLP--TNGAA 244 Query: 248 YEKIVSGKV-RFPSHFSSDLKDLLRNLLQVDLTKR 281 + I G P S LL+N++Q D +R Sbjct: 245 WHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQR 279 >6BFN-A nrPDB Length = 342 Score = 166 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 50/207 (24%), Positives = 82/207 (39%), Gaps = 21/207 (10%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH-TLNEKRILQAVNFPFLVKL 107 +G G FG V + T +A+K L + ++ ++ L E L P +V Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 108 EYSFKDNSNLYMVMEYVPGGEMFSHLRRIG----RFSEPHARFYAAQIVLTFEYLH--SL 161 N +V ++P G + L S P ++LH S Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKR------------VKGRTWTLCGTPEYLAPE 209 LI+ D+K N+L+D++ ++ DFG A+ + RT T+ GT YL E Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE 206 Query: 210 IILSKGYNKAVDWWALGVLIYEMAAGY 236 I + D ++ GV++ E AG Sbjct: 207 YIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >4MD7-E nrPDB Length = 391 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 63/346 (18%), Positives = 122/346 (35%), Gaps = 60/346 (17%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D ++ ++ LG G + V + K++K + + E +IL+ + Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLRG 90 Query: 102 -PFLVKLEYSFKDN--SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 P ++ L KD +V E+V + ++ RFY +I+ +Y Sbjct: 91 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 147 Query: 159 HSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK-GRTWTL-CGTPEYLAPEIIL-SK 214 HS+ +++RD+KP N++ID + +++ D+G A+ G+ + + + + PE+++ + Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 207 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPI--------------QIYEKIVSGKVRFPS 260 Y+ ++D W+LG ++ M PFF +Y+ I + Sbjct: 208 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 267 Query: 261 HF------------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHK 296 F S + D L LL+ D R + H Sbjct: 268 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAMEHP 322 Query: 297 WFATTDWIAIYQRKVEAPFI-PKFKGPGDTSNFDDYEEEEIRVSIN 341 +F T P S E E + Sbjct: 323 YFYTVVKDQARMGSSSMPGGSEPVSSANMMSGISSVPEPEPLGPLA 368 >2JD5-A nrPDB Length = 373 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 77/366 (21%), Positives = 133/366 (36%), Gaps = 87/366 (23%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF- 101 ++ ++ LG G F V L K H AMKI+ KV E +E ++LQ VN Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVY----TEAAEDEIKLLQRVNDA 75 Query: 102 ----------PFLVKLEYSFKDNS----NLYMVMEYVPGGEMFSHLRRIGRFSEPHA--R 145 ++KL F ++ MV E V G + + +++ P + Sbjct: 76 DNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFE-VLGENLLALIKKYEHRGIPLIYVK 134 Query: 146 FYAAQIVLTFEYLHSL-DLIYRDLKPENLLID------QQGYIQVTDFGFAKRVKGRTWT 198 + Q++L +Y+H +I+ D+KPEN+L++ I++ D G A Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTN 194 Query: 199 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF----------ADQPIQI- 247 T EY +PE++L + D W+ LI+E+ G F D QI Sbjct: 195 SIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQII 254 Query: 248 -------------------------------------YEKIVSGKVRFPSHFSSDLKDLL 270 E +++ K +F + ++ D L Sbjct: 255 ELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFL 314 Query: 271 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN-FD 329 +LQ+D KR + NH W T + ++ P + D F+ Sbjct: 315 SPMLQLDPRKR-----ADAGGLVNHPWLKDT----LGMEEIRVPDRELYGSGSDIPGWFE 365 Query: 330 DYEEEE 335 + + + Sbjct: 366 EVRDHK 371 >4M66-A nrPDB Length = 325 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 123/290 (42%), Gaps = 39/290 (13%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 A ++ ++++ +G G FG V H+ + A+KI++ +K+ E + Sbjct: 13 AVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW---------EVK 63 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLY-----MVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149 + + ++ L +D + +V ++ G + L+ P Sbjct: 64 AMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQ 123 Query: 150 QIVLTFEYLHSLD--LIYRDLKPENLLIDQQGYIQVTDFGFAKR---------VKGRTWT 198 ++VL YLHSLD L++RDLKP N+L+D + + ++ DFG + + Sbjct: 124 EVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRD 183 Query: 199 LCGTPEYLAPEIIL--SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV 256 GT YL PE++ + +KA D ++ G+L++ + AG D+ I E + + Sbjct: 184 SGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQS 243 Query: 257 RFP----SHFSSD------LKDLLRNLLQVDLTKR--FGNLKNGVNDIKN 294 R P S + LK+L+ + R F + + N++ N Sbjct: 244 RPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYN 293 >1PY5-A nrPDB Length = 326 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 60/290 (20%), Positives = 110/290 (37%), Gaps = 58/290 (20%) Query: 46 RIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ--AVNFPF 103 +++G G FG V K + G A+KI ++ E I Q + Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSS------REERSWFREAEIYQTVMLRHEN 84 Query: 104 LVKLEYSFKDNS----NLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 ++ + ++ L++V +Y G +F +L R E + A +LH Sbjct: 85 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIK-LALSTASGLAHLH 143 Query: 160 --------SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL-------CGTPE 204 + +RDLK +N+L+ + G + D G A R T T+ GT Sbjct: 144 MEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKR 203 Query: 205 YLAPEI----ILSKGYN--KAVDWWALGVLIYEMAAG----------YPPFFA----DQP 244 Y+APE+ I K + K D +A+G++ +E+A P++ D Sbjct: 204 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPS 263 Query: 245 IQIYEKIV---SGKVRFPSHF-SSDL----KDLLRNLLQVDLTKRFGNLK 286 ++ K+V + P+ + S + ++R + R L+ Sbjct: 264 VEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALR 313 >2RIO-A nrPDB Length = 434 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 64/326 (19%), Positives = 119/326 (36%), Gaps = 66/326 (20%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRIL-QAVNFPFLVK 106 K LG GS G V+ + G A+K + + L E ++L ++ + P +++ Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFC------DIALMEIKLLTESDDHPNVIR 73 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR-------FYAAQIVLTFEYLH 159 S + LY+ +E + + E QI +LH Sbjct: 74 YYCSETTDRFLYIALELC-NLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLH 132 Query: 160 SLDLIYRDLKPENLLID-------------QQGYIQVTDFGFAKRVKGRTWTLC------ 200 SL +I+RDLKP+N+L+ + I ++DFG K++ + Sbjct: 133 SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNP 192 Query: 201 -GTPEYLAPEIILS-------KGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKI 251 GT + APE++ + +++D +++G + Y + + G PF + I Sbjct: 193 SGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE--SNI 250 Query: 252 VSGKVRFPS-------HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI 304 + G ++ DL+ ++ D KR + H F Sbjct: 251 IRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKR-----PTAMKVLRHPLF------ 299 Query: 305 AIYQRKVEAPFIPKFKGPGDTSNFDD 330 +K+E F+ K + N D Sbjct: 300 WPKSKKLE--FLLKVSDRLEIENRDP 323 >2C47-A nrPDB Length = 313 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 71/309 (22%), Positives = 121/309 (39%), Gaps = 39/309 (12%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 F K +G G+FG + L K+ T + A+K+ + +E+ K++ P Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFY-KQLSATEGVP 63 Query: 103 FLVKLEYSFKDNSNLYMVMEYV--PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 ++ Y MV+E + ++F R F+ A Q++ EY+H+ Sbjct: 64 ---QVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT--FTLKTVLMIAIQLITRMEYVHT 118 Query: 161 LDLIYRDLKPENLLIDQQGY-----IQVTDFGFAKRVKG----------RTWTLCGTPEY 205 LIYRD+KPEN L+ + G I + DFG AK +L GT Y Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 178 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFP--- 259 ++ L K ++ D ALG + G P+ D + Y+KI K P Sbjct: 179 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 238 Query: 260 --SHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWF---ATTDWIAIYQRKVE 312 +F ++ LR + ++D ++ + L+ D+ + F DW + + Sbjct: 239 LCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAG---KPLP 295 Query: 313 APFIPKFKG 321 P Sbjct: 296 TPIGTVHTD 304 >6HMD-A nrPDB Length = 365 Score = 163 bits (414), Expect = 7e-41, Method: Composition-based stats. Identities = 63/317 (19%), Positives = 124/317 (39%), Gaps = 59/317 (18%) Query: 30 KWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHT 89 +E + + D ++ ++ LG G + V + K++K + + Sbjct: 41 DYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNER------VVVKILKPVKKKKI 94 Query: 90 LNEKRILQAVNFP-FLVKLEYSFKDN--SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 146 E +IL+ + ++KL + KD +V EY+ + F L +I ++ RF Sbjct: 95 KREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRF 151 Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ-QGYIQVTDFGFAKRVKG--RTWTLCGTP 203 Y +++ +Y HS +++RD+KP N++ID Q +++ D+G A+ + Sbjct: 152 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASR 211 Query: 204 EYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI--------------QIY 248 + PE+++ + Y+ ++D W+LG ++ M PFF Q ++Y Sbjct: 212 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 271 Query: 249 EKIVSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGN 284 + + HF S + DLL LL+ D +R Sbjct: 272 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-- 329 Query: 285 LKNGVNDIKNHKWFATT 301 + H +F Sbjct: 330 ---TAKEAMEHPYFYPV 343 >2QKW-B nrPDB Length = 321 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 50/224 (22%), Positives = 93/224 (41%), Gaps = 17/224 (7%) Query: 24 KEDFLKKWENPAQNTAHLDQ----FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQK 79 +L +E+ L++ F+ +G G FG+V ++ G A+K ++ Sbjct: 17 SSSYLVPFESYRVPLVDLEEATNNFDHKFLIGHGVFGKVYKGVLRD-GAKVALK---RRT 72 Query: 80 VVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIG-- 137 + IE E L P LV L + + + ++ +Y+ G + HL Sbjct: 73 PESSQGIEEFETEIETLSFCRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLP 132 Query: 138 --RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR 195 S YLH+ +I+RD+K N+L+D+ ++TDFG +K+ Sbjct: 133 TMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTEL 192 Query: 196 TWT-----LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA 234 T + GT Y+ PE + + D ++ GV+++E+ Sbjct: 193 DQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVLC 236 >4PL5-B nrPDB Length = 435 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 55/273 (20%), Positives = 108/273 (39%), Gaps = 39/273 (14%) Query: 49 TLGTGSFGR-VMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-FPFLVK 106 LG G+ G V A+K + + E ++L+ + P +++ Sbjct: 34 VLGHGAEGTIVYKGMF--DNRDVAVKRIL------PECFSFADREVQLLRESDEHPNVIR 85 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP-HARFYAAQIVLTFEYLHSLDLIY 165 + KD Y+ +E + ++ + Q +LHSL++++ Sbjct: 86 YFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVH 144 Query: 166 RDLKPENLLI---DQQGYIQ--VTDFGFAKRVK------GRTWTLCGTPEYLAPEIILS- 213 RDLKP N+L+ + G I+ ++DFG K++ R + GT ++APE++ Sbjct: 145 RDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSED 204 Query: 214 --KGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGKVRFPSHFSSD----- 265 VD ++ G + Y + + GY PF + +Q I+ G S Sbjct: 205 CKDNPTYTVDIFSAGCVFYYVISEGYHPF--GKSLQRQANILLGACNLDCFHSDKHEDVI 262 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 ++L+ ++ +D +R + H +F Sbjct: 263 ARELIEKMIAMDPQQR-----PSAKHVLKHPFF 290 >4CRL-A nrPDB Length = 406 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 69/353 (19%), Positives = 133/353 (37%), Gaps = 85/353 (24%) Query: 21 AKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNH--FAMKILDKQ 78 K DF K + + L ++E K G G++G V K K+ + +A+K ++ Sbjct: 2 DKMDYDFKVKLSSERERVEDLFEYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEGT 60 Query: 79 KVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDN--SNLYMVMEYVPGGEMFSHLR-- 134 + E +L+ + P ++ L+ F + ++++ +Y +++ ++ Sbjct: 61 GISMS-----ACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFH 114 Query: 135 -------RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI----DQQGYIQV 183 + + + QI+ YLH+ +++RDLKP N+L+ ++G +++ Sbjct: 115 RASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKI 174 Query: 184 TDFGFAKRVKG------RTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGY 236 D GFA+ + T Y APE++L + Y KA+D WA+G + E+ Sbjct: 175 ADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSE 234 Query: 237 PPFFADQ---------PIQIYEKIVSGKVRFP-----------SHFSSDLKD-------- 268 P F Q ++I + + FP S+ +KD Sbjct: 235 PIFHCRQEDIKTSNPYHHDQLDRIFNV-MGFPADKDWEDIKKMPEHSTLMKDFRRNTYTN 293 Query: 269 --------------------LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 LL+ LL +D KR + +F Sbjct: 294 CSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITS-----EQAMQDPYFLED 341 >3VHK-A nrPDB Length = 368 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 36/168 (21%), Positives = 79/168 (47%), Gaps = 13/168 (7%) Query: 136 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KG 194 + H Y+ Q+ E+L S I+RDL N+L+ ++ +++ DFG A+ + K Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKD 253 Query: 195 RTWTLCGTPE----YLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIY- 248 + G ++APE I + Y D W+ GVL++E+ + G P+ + + + Sbjct: 254 PDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFC 313 Query: 249 EKIVSG-KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNH 295 ++ G ++R P + + ++ + + + ++R +++ H Sbjct: 314 RRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR-----PTFSELVEH 356 Score = 81.1 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 15/117 (12%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLV-----KHKETGNHFAMKILDKQKVVKL 83 KWE P D+ + K LG G+FG+V+ T A+K+L + Sbjct: 22 SKWEFPR------DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGA--TH 73 Query: 84 KQIEHTLNEKRILQAV-NFPFLVKLEYSFKD-NSNLYMVMEYVPGGEMFSHLRRIGR 138 + ++E +IL + + +V L + L +++E+ G + ++LR Sbjct: 74 SEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRN 130 >6HV0-A nrPDB Length = 416 Score = 160 bits (406), Expect = 6e-40, Method: Composition-based stats. Identities = 57/304 (18%), Positives = 116/304 (38%), Gaps = 47/304 (15%) Query: 49 TLGTGSFGR-VMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-FPFLVK 106 LG G+ G V A+K + + E ++L+ + P +++ Sbjct: 15 VLGHGAEGTIVYRGMF--DNRDVAVKRIL------PECFSFADREVQLLRESDEHPNVIR 66 Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP-HARFYAAQIVLTFEYLHSLDLIY 165 + KD Y+ +E + ++ + Q +LHSL++++ Sbjct: 67 YFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVH 125 Query: 166 RDLKPENLLI---DQQGYIQ--VTDFGFAKRVK------GRTWTLCGTPEYLAPEIILS- 213 RDLKP N+LI + G I+ ++DFG K++ R + GT ++APE++ Sbjct: 126 RDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSED 185 Query: 214 --KGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGKVRFPSHFSSD----- 265 + VD ++ G + Y + + G PF + +Q I+ G Sbjct: 186 CKENPTYTVDIFSAGCVFYYVISEGSHPF--GKSLQRQANILLGACSLDCLHPEKHEDVI 243 Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDT 325 ++L+ ++ +D KR + H +F +++++ F + Sbjct: 244 ARELIEKMIAMDPQKR-----PSAKHVLKHPFF------WSLEKQLQ--FFQDVSDRIEK 290 Query: 326 SNFD 329 + D Sbjct: 291 ESLD 294 >3LLT-A nrPDB Length = 360 Score = 160 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 108/257 (42%), Gaps = 37/257 (14%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + F I+ +G G+FGRV+L +H + ++A+K++ K K E IL+ + Sbjct: 35 NAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIK----KYTRSAKIEADILKKIQN 90 Query: 102 PFL-----VKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR--IGRFSEPHARFYAAQIVLT 154 + VK F ++ ++ E + G ++ + R F + Y +I+ Sbjct: 91 DDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEILKA 149 Query: 155 FEYLHSLDLIYRDLKPENLLIDQ-------------------------QGYIQVTDFGFA 189 YL + L + DLKPEN+L+D I++ DFG A Sbjct: 150 LNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCA 209 Query: 190 KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE 249 ++ T +Y APE+IL+ G++ + D W+ G ++ E+ G F + ++ Sbjct: 210 TFKSDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLA 269 Query: 250 KIVSGKVRFPSHFSSDL 266 + S P + + Sbjct: 270 MMESIIQPIPKNMLYEA 286 >2PVN-A nrPDB Length = 352 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 59/339 (17%), Positives = 123/339 (36%), Gaps = 59/339 (17%) Query: 9 KGSEQESVKEFLAKAKEDFLKKWENPAQNTA--HLDQFERIKTLGTGSFGRVMLVKHKET 66 +GS + + + W+ A D +E ++ +G G + V + Sbjct: 17 RGSHMSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNN 76 Query: 67 GNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKD--NSNLYMVMEYV 124 + + +K+ + K + P +VKL +D + ++ EYV Sbjct: 77 NEKC-----IIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYV 131 Query: 125 PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQV 183 + F L ++ R+Y +++ +Y HS +++RD+KP N++ID + +++ Sbjct: 132 NNTD-FKVL--YPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRL 188 Query: 184 TDFGFAKRVK-GRTWTL-CGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPP-F 239 D+G A+ G+ + + + + PE+++ + Y+ ++D W+LG + M P F Sbjct: 189 IDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFF 248 Query: 240 FADQPIQIYEKIVSG-------------KVRFPSH------------------------F 262 + KI ++ Sbjct: 249 YGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLV 308 Query: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 S + D L LL+ D +R L + H +F Sbjct: 309 SPEAIDFLDKLLRYDHQERLTAL-----EAMTHPYFQQV 342 >5XVU-A nrPDB Length = 332 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 127/322 (39%), Gaps = 66/322 (20%) Query: 25 EDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLK 84 ++ +W P +++E +K +G G + V E A KV+K Sbjct: 21 DNLELQWNKP-------NRYEIMKKIGRGKYSEVFNGYDTECNRPCA------IKVLKPV 67 Query: 85 QIEHTLNEKRILQAVNF-PFLVKLEYSFKDN--SNLYMVMEYVPGGEMFSHLRRIGRFSE 141 + + E +ILQ +N P ++KL KD ++ EY+ + + +F++ Sbjct: 68 KKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL---YPKFTD 124 Query: 142 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVK-GRTWTL 199 R+Y QI+ +Y HS +++RD+KP N++ID + I++ +G A+ G+ + + Sbjct: 125 KDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNV 184 Query: 200 -CGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-ADQPIQIYEKIVS--- 253 + Y PE+++ + Y+ ++D W+LG ++ M PFF KI Sbjct: 185 RVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLG 244 Query: 254 --------GKVRF---PSHFS-----------------------SDLKDLLRNLLQVDLT 279 K P + + ++ DL+ +L D Sbjct: 245 TEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHA 304 Query: 280 KRFGNLKNGVNDIKNHKWFATT 301 KR + H +F Sbjct: 305 KRIAP-----KEAMEHPYFREV 321 >5L2Q-C nrPDB Length = 320 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 117/280 (41%), Gaps = 49/280 (17%) Query: 59 MLVKHKETGNHFAMKILDKQK-----VVKLKQIEHTL---NEKRILQAVN-FPFLVKLEY 109 L + T + + +KIL ++ + ++ + + E +L ++ +V Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 110 SFKD------------------NSNLYMVMEYVPGGE----------MFSHLRRIGRFSE 141 F+D + +V++ + + + ++ + R SE Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 142 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVKGR---TW 197 +V E LH ++++RDLK N++++++ + I +T+F K + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 198 TLCGTPEYLAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV 256 G+P Y++P+++ + Y K D WALGV+++ M G PF+ P +++ KI + + Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 257 RFPS--HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKN 294 P S + L+R LL +D +R D+ Sbjct: 273 TIPEDGRVSENTVCLIRKLLVLDPQQRLA-----AADVLE 307 >6EII-A nrPDB Length = 352 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 117/305 (38%), Gaps = 59/305 (19%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 D ++ ++ LG G + V + K++K + + E +IL+ + Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLRG 113 Query: 102 -PFLVKLEYSFKDN--SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 P ++ L KD +V E+V + ++ RFY +I+ +Y Sbjct: 114 GPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYC 170 Query: 159 HSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVK-GRTWTL-CGTPEYLAPEIIL-SK 214 HS+ +++RD+KP N++ID + +++ D+G A+ G+ + + + + PE+++ + Sbjct: 171 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ 230 Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPI--------------QIYEKIVSGKVRFPS 260 Y+ ++D W+LG ++ M PFF +Y+ I + Sbjct: 231 MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDP 290 Query: 261 HF------------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHK 296 F S + D L LL+ D R + H Sbjct: 291 RFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAMEHP 345 Query: 297 WFATT 301 +F T Sbjct: 346 YFYTV 350 >3REP-A nrPDB Length = 271 Score = 156 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 51/254 (20%), Positives = 107/254 (42%), Gaps = 20/254 (7%) Query: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 Q + L G + + + GN +K+L + K E L+ + Sbjct: 9 FKQLNFLTKLNENHSGELWKGRWQ--GNDIVVKVLKVRDWSTRKS-RDFNEECPRLRIFS 65 Query: 101 FPFLVKLEYSFKDNS--NLYMVMEYVPGGEMFSHLRRIGRF--SEPHARFYAAQIVLTFE 156 P ++ + + + + ++ ++P G +++ L F + A +A + Sbjct: 66 HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMA 125 Query: 157 YLHSLD-LIYRD-LKPENLLIDQQGYIQV--TDFGFAKRVKGRTWTLCGTPEYLAPEIIL 212 +LH+L+ LI R L +++ID+ ++ D F+ + GR + P ++APE + Sbjct: 126 FLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYA----PAWVAPEALQ 181 Query: 213 SKGYN---KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI-VSG-KVRFPSHFSSDLK 267 K + ++ D W+ VL++E+ PF ++I K+ + G + P S + Sbjct: 182 KKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVS 241 Query: 268 DLLRNLLQVDLTKR 281 L++ + D KR Sbjct: 242 KLMKICMNEDPAKR 255 >4NT4-A nrPDB Length = 312 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 71/292 (24%), Positives = 112/292 (38%), Gaps = 32/292 (10%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 F K +G G+FG + L K+ H A+K+ + +E+ + A N P Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 72 Query: 103 FLVKLEYSFKDNSNLY--MVMEYVPGGEMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLH 159 + Y Y MV+E + G + R FS A Q++ EY+H Sbjct: 73 DGIPRIYHLGTCGGRYNAMVLELL-GLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVH 131 Query: 160 SLDLIYRDLKPENLLIDQQGY-----IQVTDFGFAKRVKG----------RTWTLCGTPE 204 S LIYRD+KPEN LI + I + DFG AK +L GT Sbjct: 132 SRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTAR 191 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFPSH 261 Y++ + + ++ D ALG + G P+ D + Y+KI K P Sbjct: 192 YMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIE 251 Query: 262 F-----SSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHKWFAT---TDW 303 + LR + ++D + + L+ D+ + K + DW Sbjct: 252 VLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFDRKGYTDEGEFDW 303 >4IAN-A nrPDB Length = 358 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 99/224 (44%), Gaps = 17/224 (7%) Query: 51 GTGSFGRVMLVKHK-ETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP------F 103 G G F V+ + A+KI+ ++++ L E L+ +N Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG----LKELEFLKKLNDADPDDKFH 94 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR---FSEPHARFYAAQIVLTFEYLHS 160 ++L F +L +V E + + L++ G+ R Y+ Q+ L + L Sbjct: 95 CLRLFRHFYHKQHLCLVFEPLS-MNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKR 153 Query: 161 LDLIYRDLKPENLLIDQQGYI-QVTDFGFAKRVKGRTWT-LCGTPEYLAPEIILSKGYNK 218 ++++ D+KP+N+L+++ I ++ DFG A V T + Y APEII+ K Y+ Sbjct: 154 CNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDY 213 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF 262 +D W++G +YE+ G F + + + K + P+ Sbjct: 214 GIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKM 257 Score = 31.0 bits (69), Expect = 0.73, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 15/35 (42%), Gaps = 5/35 (14%) Query: 266 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 LKDLL +L +D KR +N H + Sbjct: 321 LKDLLDQILMLDPAKRI-----SINQALQHAFIQE 350 >3G2F-A nrPDB Length = 336 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 60/321 (18%), Positives = 113/321 (35%), Gaps = 71/321 (22%) Query: 35 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKR 94 ++ + LD + ++ +G G +G V E A+K+ ++ +NEK Sbjct: 6 SEPSLDLDNLKLLELIGRGRYGAVYKGSLDE--RPVAVKVFS------FANRQNFINEKN 57 Query: 95 ILQ--AVNFPFLVKL----EYSFKDNSNLYM-VMEYVPGGEMFSHLRRIGRFSEPHARFY 147 I + + + + E D Y+ VMEY P G + +L R Sbjct: 58 IYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCR-L 116 Query: 148 AAQIVLTFEYLHS---------LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW- 197 A + YLH+ + +RDL N+L+ G ++DFG + R+ G Sbjct: 117 AHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLV 176 Query: 198 ----------TLCGTPEYLAPEIILS-------KGYNKAVDWWALGVLIYEMAAGYP-PF 239 + GT Y+APE++ + K VD +ALG++ +E+ F Sbjct: 177 RPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLF 236 Query: 240 FADQ-------------------PIQIYEKIVSGKVRFPSHFSS------DLKDLLRNLL 274 + +Q+ + +FP + LK+ + + Sbjct: 237 PGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCW 296 Query: 275 QVDLTKRFG--NLKNGVNDIK 293 D R + + ++ Sbjct: 297 DQDAEARLTAQCAEERMAELM 317 >3QD2-B nrPDB Length = 332 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 62/341 (18%), Positives = 116/341 (34%), Gaps = 87/341 (25%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILD-----------KQKVVKLKQI 86 + +L FE I+ +G G FG V K+K ++A+K + ++V L ++ Sbjct: 2 SRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL 61 Query: 87 EH--------------------TLNEKRI------------------------LQAVNFP 102 EH ++E + + + Sbjct: 62 EHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTK 121 Query: 103 FLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH---ARFYAAQIVLTFEYLH 159 V LY+ M+ + + R + QI E+LH Sbjct: 122 NTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLH 181 Query: 160 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT---------------WTLCGTPE 204 S L++RDLKP N+ ++V DFG + GT Sbjct: 182 SKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKL 241 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-VRFPSHFS 263 Y++PE I Y+ VD ++LG++++E+ + ++ I + ++FP F+ Sbjct: 242 YMSPEQIHGNNYSHKVDIFSLGLILFELLYSFS-----TQMERVRIITDVRNLKFPLLFT 296 Query: 264 ---SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 +++++L T+R DI + F Sbjct: 297 QKYPQEHMMVQDMLSPSPTER-----PEATDIIENAIFENL 332 >1CSN-A nrPDB Length = 298 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 103/279 (36%), Gaps = 33/279 (11%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-NF 101 ++ + +G GSFG + + A+K ++ Q+ ++L Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRS--DAPQLRDEYRTYKLLAGCTGI 68 Query: 102 PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAAQIVLTFEYLHS 160 P + Y ++ + +V++ + G + L GR FS A Q++ + +H Sbjct: 69 PNV---YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHE 124 Query: 161 LDLIYRDLKPENLLIDQQG-----YIQVTDFGFAKRVKG----------RTWTLCGTPEY 205 L+YRD+KP+N LI + I V DFG K + L GT Y Sbjct: 125 KSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARY 184 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFP--- 259 ++ L + ++ D ALG + G P+ Q YE+I K P Sbjct: 185 MSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRE 244 Query: 260 --SHFSSDLKDLLRNL--LQVDLTKRFGNLKNGVNDIKN 294 + F + + L D T + L+ + + Sbjct: 245 LCAGFPEEFYKYMHYARNLAFDATPDYDYLQGLFSKVLE 283 >5X18-A nrPDB Length = 295 Score = 151 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 63/251 (25%), Positives = 108/251 (43%), Gaps = 32/251 (12%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 ++ K +G GSFG + + G A+K ++ + Q+ +IL P Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRK--TEAPQLRDEYKTYKILNGT--P 63 Query: 103 FLVKLEYSFKDNSNLYMVMEYV--PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 + Y ++ + +V++ + ++F R +FS A Q++ E LH+ Sbjct: 64 NIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGR--KFSVKTVVQVAVQMITLIEDLHA 121 Query: 161 LDLIYRDLKPENLLIDQQGY-----IQVTDFGFAKRVKG----------RTWTLCGTPEY 205 DLIYRD+KP+N LI + G I + DFG AK+ + +L GT Y Sbjct: 122 HDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARY 181 Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKVRFPSHF 262 ++ L + ++ D ALG + + G+ P+ Q YEKI K Sbjct: 182 MSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKR------ 235 Query: 263 SSDLKDLLRNL 273 S+++ DL + L Sbjct: 236 STNVYDLAQGL 246 >4WUA-A nrPDB Length = 401 Score = 151 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 65/410 (15%), Positives = 128/410 (31%), Gaps = 128/410 (31%) Query: 10 GSEQESVKEFLAKAKEDFLKK--------WENPAQNTAHLDQFERIKTLGTGSFGRVMLV 61 GS +E + + +D + + ++ I+ LG G F V L Sbjct: 1 GSHMPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLS 60 Query: 62 KHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF--PF------LVKLEYSFK- 112 + AMK++ + E L+E R+L++V P +V+L FK Sbjct: 61 WDIQGKKFVAMKVVKSAEHY----TETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKI 116 Query: 113 ---DNSNLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSL-DLIYRD 167 + +++ MV E + + ++ P + Q++ +YLH+ +I+ D Sbjct: 117 SGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTD 176 Query: 168 LKPENLLID-------------------------------------------------QQ 178 +KPEN+L+ ++ Sbjct: 177 IKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEK 236 Query: 179 GYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP 238 +++ D G A V T +Y + E+++ GYN D W+ + +E+A G Sbjct: 237 LKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYL 296 Query: 239 FFADQP-------------------------------IQIYEK----------------- 250 F + + K Sbjct: 297 FEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFE 356 Query: 251 IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 ++ K + ++ D L +L++ KR + H W + Sbjct: 357 VLVEKYEWSQEEAAGFTDFLLPMLELIPEKR-----ATAAECLRHPWLNS 401 >5M07-A nrPDB Length = 276 Score = 150 bits (379), Expect = 9e-37, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 99/262 (37%), Gaps = 32/262 (12%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + ++ LG + G V LV+H A+K+L + E + + P Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 104 LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLHSL 161 ++++ + + L++ M+YV G + H+ + +Y H Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQR 151 Query: 162 DLIYRDLKPENLLIDQ----QGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYN 217 L++RD+ P N+++ I + DFG A + P Y APE+ + Sbjct: 152 GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------PSYPAPELSAGADVD 200 Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP--SHFSSDLKDL---LRN 272 D +AL + + AG PP ++ +G ++ P S F DL L L Sbjct: 201 GRADQYALALTAIHLFAGAPP---------VDRSHTGPLQPPKLSAFRPDLARLDGVLSR 251 Query: 273 LLQVDLTKRFGNLKNGVNDIKN 294 L RFG+ + D N Sbjct: 252 ALATAPADRFGSCRE-FADAMN 272 >4XHH-A nrPDB Length = 403 Score = 150 bits (379), Expect = 9e-37, Method: Composition-based stats. Identities = 51/267 (19%), Positives = 110/267 (41%), Gaps = 31/267 (11%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-VNF 101 +F + +G+GSFG + + +G A+++ + + Q+++ + L V Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRS--RHPQLDYESRVYKYLSGGVGI 65 Query: 102 PFLVKLEYSFKDNSNLYMVMEYV--PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 PF+ + ++ MV++ + ++F++ R +FS A Q++ +Y+H Sbjct: 66 PFI---RWFGREGEYNAMVIDLLGPSLEDLFNYCHR--KFSFKTVIMLALQMICRVQYIH 120 Query: 160 SLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKG----------RTWTLCGTPEYL 206 I+RD+KP+N L+ + + V DFG +K+ + +L GT Y Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYA 180 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKV-----RF 258 + L ++ D +LG ++ G P+ Q Y++I+ K+ Sbjct: 181 SVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETL 240 Query: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNL 285 + + + + + +R L Sbjct: 241 CAGLPLEFSEYMNYCRNLKFDERPDYL 267 >5E8V-A nrPDB Length = 316 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 50/293 (17%), Positives = 106/293 (36%), Gaps = 59/293 (20%) Query: 45 ERIKTLGTGSFGRVMLVKHKETG----NHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100 E +G G F V K K+ A+KI ++ K + ++ + Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN----LK 67 Query: 101 FPFLVKLEYSFKDNSNL----YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 +++ + + + L +++ + G + +L R S R + + Sbjct: 68 HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLGSSLARGIA 126 Query: 157 YLHS---------LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT-------LC 200 +LHS + +++RDLK N+L+ + DFG + R+ Sbjct: 127 HLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQV 186 Query: 201 GTPEYLAPEIILS-------KGYNKAVDWWALGVLIYEMAAG----------YPPF---- 239 GT Y+APE++ S + + K D +++ ++++EM + PPF Sbjct: 187 GTARYMAPEVLASAMNLENVESF-KQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKV 245 Query: 240 -FADQPIQIYEKIV--SGKVRFPSHFSSD-----LKDLLRNLLQVDLTKRFGN 284 + + ++ +G+ PS + + + + L D R Sbjct: 246 REHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTA 298 >4BTK-A nrPDB Length = 337 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 50/260 (19%), Positives = 99/260 (38%), Gaps = 24/260 (9%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 ++ + N D+++ +K +G G FG + T + A+K+ Q+ ++ ++ Sbjct: 43 EQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM-- 100 Query: 89 TLNEKRILQAVNF-PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR--IGRFSEPHAR 145 E +L+ + + + ++ Y+VM+ G + R G F+ Sbjct: 101 ---EVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTL 156 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENL----LIDQQGYIQVTDFGFAKRVKGRTW---- 197 QI+ + E +HS+ ++RD+KP N L + DFG A++ T Sbjct: 157 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRP 216 Query: 198 -----TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252 GT Y + ++ + D W+L ++ E A G P+ + + I Sbjct: 217 PRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIK 276 Query: 253 SGKVR--FPSHFSSDLKDLL 270 H S+ L Sbjct: 277 EKYEHRMLLKHMPSEFHLFL 296 >4NFN-A nrPDB Length = 309 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 50/260 (19%), Positives = 99/260 (38%), Gaps = 24/260 (9%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEH 88 ++ + N D+++ +K +G G FG + T + A+K+ Q+ ++ ++ Sbjct: 8 EQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM-- 65 Query: 89 TLNEKRILQAVNF-PFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRR--IGRFSEPHAR 145 E +L+ + + + ++ Y+VM+ G + R G F+ Sbjct: 66 ---EVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTL 121 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENL----LIDQQGYIQVTDFGFAKRVKGRTW---- 197 QI+ + E +HS+ ++RD+KP N L + DFG A++ T Sbjct: 122 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRP 181 Query: 198 -----TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252 GT Y + ++ + D W+L ++ E A G P+ + + I Sbjct: 182 PRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIK 241 Query: 253 SGKVR--FPSHFSSDLKDLL 270 H S+ L Sbjct: 242 EKYEHRMLLKHMPSEFHLFL 261 >4RT7-A nrPDB Length = 415 Score = 148 bits (373), Expect = 5e-36, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 83/221 (37%), Gaps = 25/221 (11%) Query: 91 NEKRILQAVNFPFLVKLEY-SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149 E +I + + L SF + EY + + + +A Sbjct: 198 REVQI--HPDSDQISGLHGNSFHSEDEI----EYENQKRLEEE-EDLNVLTFEDLLCFAY 250 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPE---- 204 Q+ E+L ++RDL N+L+ +++ DFG A+ + + + G Sbjct: 251 QVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVK 310 Query: 205 YLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG--KVRFPSH 261 ++APE + Y D W+ G+L++E+ + G P+ + K++ K+ P + Sbjct: 311 WMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFY 370 Query: 262 FSSDLKDLLRNLLQVDLTKR---------FGNLKNGVNDIK 293 + ++ ++++ D KR G + Sbjct: 371 ATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAM 411 Score = 97.2 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 28/119 (23%), Positives = 57/119 (47%), Gaps = 14/119 (11%) Query: 26 DFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKH---KETG--NHFAMKILDKQKV 80 ++ KWE P + E K LG+G+FG+VM +TG A+K+L ++ Sbjct: 55 EYDLKWEFPR------ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA- 107 Query: 81 VKLKQIEHTLNEKRILQAV-NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR 138 + E ++E +++ + + +V L + + +Y++ EY G++ ++LR Sbjct: 108 -DSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKRE 165 >2X7G-A nrPDB Length = 389 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 59/367 (16%), Positives = 114/367 (31%), Gaps = 118/367 (32%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF- 101 ++ I+ LG G F V L + AMK++ E L+E ++L+ V Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK----SAQHYTETALDEIKLLKCVRES 87 Query: 102 ----PF---LVKLEYSFKDNS----NLYMVMEYVPGGEMFSHLRR-IGRFSEPHARFYAA 149 P +V+L FK + ++ MV E + + ++ + Sbjct: 88 DPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIR 147 Query: 150 QIVLTFEYLHSL-DLIYRDLKPENLLI--------------------------------- 175 Q++ +YLHS +I+ D+KPEN+L+ Sbjct: 148 QVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTA 207 Query: 176 --------------DQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVD 221 + +++ D G A V T +Y + E+++ GY+ D Sbjct: 208 PAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPAD 267 Query: 222 WWALGVLIYEMAAGYPPFFADQP-------------------------------IQIYEK 250 W+ + +E+A G F + + + Sbjct: 268 IWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNR 327 Query: 251 -----------------IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIK 293 ++ K +P ++ D L +L++ KR + Sbjct: 328 RGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKR-----ASAGECL 382 Query: 294 NHKWFAT 300 H W + Sbjct: 383 RHPWLNS 389 >4L00-A nrPDB Length = 304 Score = 147 bits (371), Expect = 8e-36, Method: Composition-based stats. Identities = 60/268 (22%), Positives = 110/268 (41%), Gaps = 20/268 (7%) Query: 42 DQFERIKTLGTGS-----FGRVMLVKHKE-TGNHFAMKILDKQKVVKLKQIEHTLNEK-R 94 + + LG G+ G +M K E T +K++ K + I E Sbjct: 25 KDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAAS 84 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVL 153 +++ V+ +V L + MV E+V GG + + R + P A Q+ Sbjct: 85 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLAS 144 Query: 154 TFEYLHSLDLIYRDLKPENLLIDQQG-------YIQVTDFGFAKRVKGRTWTLCGTPEYL 206 YL DL++ ++ +NLL+ ++G +I+++D G V R + P ++ Sbjct: 145 ALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP-WI 203 Query: 207 APEIILS-KGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGKVRFPSHFSS 264 APE + K + A D W+ G ++E+ G P I+ E+ + R + Sbjct: 204 APECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEK-ERFYESRCRPVTPSCK 262 Query: 265 DLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 +L DL+ + D +R + + DI Sbjct: 263 ELADLMTRCMNYDPNQR-PFFRAIMRDI 289 >4LFI-A nrPDB Length = 374 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 57/341 (16%), Positives = 118/341 (34%), Gaps = 85/341 (24%) Query: 38 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAM-----------------------KI 74 + + +E +G G + V ++ + + Sbjct: 36 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 95 Query: 75 LDKQKVVKLKQIEHTLNEKRILQAVN----------FPFLVKLEYSFKDN--SNLYMVME 122 + + K +T ++ +L+ + ++ L KD +V E Sbjct: 96 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 155 Query: 123 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ-QGYI 181 YV + + ++ RFY +++ +Y HS+ +++RD+KP N++ID + Sbjct: 156 YVDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 212 Query: 182 QVTDFGFAK--RVKGRTWTLCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPP 238 ++ D+G A+ V + + PE+++ + Y+ ++D W+ G ++ M P Sbjct: 213 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 272 Query: 239 FF-ADQPIQIYEKIVSG-------------KVRFPSHF---------------------- 262 FF KIV ++ P F Sbjct: 273 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 332 Query: 263 --SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301 + ++ DL+ NLL+ D +R + H WFA Sbjct: 333 SGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPI 368 >4XHL-A nrPDB Length = 394 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 113/276 (40%), Gaps = 33/276 (11%) Query: 43 QFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQA-VNF 101 +F + +G+GSFG + + +G A+++ + + Q+++ R L V Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRS--RHPQLDYESRVYRYLSGGVGI 65 Query: 102 PFLVKLEYSFKDNSNLYMVMEYV--PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 PF+ + ++ MV++ + ++F++ R RFS A Q+ +Y+H Sbjct: 66 PFI---RWFGREGEYNAMVIDLLGPSLEDLFNYCHR--RFSFKTVIMLALQMFCRIQYIH 120 Query: 160 SLDLIYRDLKPENLLID---QQGYIQVTDFGFAKRVKG----------RTWTLCGTPEYL 206 I+RD+KP+N L+ + + V DFG +K+ + +L GT Y Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYA 180 Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGKV-----RF 258 + L ++ D +LG ++ G P+ Q Y++I+ K+ Sbjct: 181 SVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETL 240 Query: 259 PSHFSSDLKDLLRNL--LQVDLTKRFGNLKNGVNDI 292 S + ++ + L+ D + L D+ Sbjct: 241 CSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDL 276 >4M69-B nrPDB Length = 283 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 37/228 (16%), Positives = 90/228 (39%), Gaps = 16/228 (7%) Query: 70 FAMKILDKQKVVKLKQIEHTLN-EKRILQAVNFPFLVKLEYSFKD----NSNLYMVMEYV 124 +K+ + + + + T N E + ++ + P ++++ D +VMEY Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 94 Query: 125 PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184 G + L R + + LH + ++R++ + L+ +++ Sbjct: 95 ELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLA 154 Query: 185 DFGFAKRVKGRTWTLCGTPE-------YLAPEIILS--KGYNKAVDWWALGVLIYEMAAG 235 F +K + T T Y++PE + + Y+ + ++ G++++E+A G Sbjct: 155 GFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATG 214 Query: 236 YPPFFADQPIQIYEKIVSGKVRFP--SHFSSDLKDLLRNLLQVDLTKR 281 PF +I E + K + P L++++ + ++R Sbjct: 215 KIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQR 262 >4BTF-A nrPDB Length = 469 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 37/228 (16%), Positives = 90/228 (39%), Gaps = 16/228 (7%) Query: 70 FAMKILDKQKVVKLKQIEHTLN-EKRILQAVNFPFLVKLEYSFKD----NSNLYMVMEYV 124 +K+ + + + + T N E + ++ + P ++++ D +VMEY Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 280 Query: 125 PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184 G + L R + + LH + ++R++ + L+ +++ Sbjct: 281 ELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLA 340 Query: 185 DFGFAKRVKGRTWTLCGTPE-------YLAPEIILS--KGYNKAVDWWALGVLIYEMAAG 235 F +K + T T Y++PE + + Y+ + ++ G++++E+A G Sbjct: 341 GFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATG 400 Query: 236 YPPFFADQPIQIYEKIVSGKVRFP--SHFSSDLKDLLRNLLQVDLTKR 281 PF +I E + K + P L++++ + ++R Sbjct: 401 KIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQR 448 >4F9B-A nrPDB Length = 361 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 53/266 (19%), Positives = 98/266 (36%), Gaps = 54/266 (20%) Query: 19 FLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ 78 LA K+D K +E Q + + F+ +G G+F V L + + + Sbjct: 1 MLAGVKKDIEKLYEAVPQLS---NVFKIEDKIGEGTFSSVYLATAQL--------QVGPE 49 Query: 79 KVVKLKQIEHTLNEKRILQAVNF-------PFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 + + LK + T + RI + ++ ++Y F+ N ++ + M Y+ Sbjct: 50 EKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLD 109 Query: 132 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ-GYIQVTDFGFAK 190 L S R Y + + +H +++RD+KP N L +++ + DFG A+ Sbjct: 110 ILNS---LSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQ 166 Query: 191 RVKGRTWTL-------------------------------CGTPEYLAPEIILSKG-YNK 218 L GTP + APE++ Sbjct: 167 GTHDTKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTT 226 Query: 219 AVDWWALGVLIYEMAAGYPPFFADQP 244 A+D W+ GV+ + +G PF+ Sbjct: 227 AIDMWSAGVIFLSLLSGRYPFYKASD 252 >3SOC-A nrPDB Length = 322 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 50/288 (17%), Positives = 104/288 (36%), Gaps = 54/288 (18%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + ++ G FG V + + A+KI ++ KQ E L + Sbjct: 26 LQLLEVKARGRFGCVWKAQLL--NEYVAVKIFP----IQDKQSWQNEYEVYSLPGMKHEN 79 Query: 104 LVKLEYSFKDNS----NLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 +++ + K + +L+++ + G + L + S A + YLH Sbjct: 80 ILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL-KANVVSWNELCHIAETMARGLAYLH 138 Query: 160 S----------LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-----GRTWTLCGTPE 204 + +RD+K +N+L+ + DFG A + + G T GT Sbjct: 139 EDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRR 198 Query: 205 YLAPEII-----LSKGYNKAVDWWALGVLIYEMAAGY-----------PPFFAD----QP 244 Y+APE++ + +D +A+G++++E+A+ PF + Sbjct: 199 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPS 258 Query: 245 IQIYEKIVSGKVRFP--SHFSSD------LKDLLRNLLQVDLTKRFGN 284 ++ +++V K + P + L + + D R Sbjct: 259 LEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >4MWI-A nrPDB Length = 294 Score = 137 bits (345), Expect = 9e-33, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 92/244 (37%), Gaps = 25/244 (10%) Query: 70 FAMKILDKQKVVKLKQIEHTLN-EKRILQAVNFPFLVKLEYSFKDNS----NLYMVMEYV 124 A+K+ K + + + T N E + ++ P ++++ D + +VMEY Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 125 PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL--IYRDLKPENLLIDQQGYIQ 182 G + L R + LH + ++ ++ N L+ Q ++ Sbjct: 110 ELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVK 169 Query: 183 VTDFGFAKRVKG-------RTWTLCGTPEYLAP---EIILSKGYNKAVDWWALGVLIYEM 232 + F K + YL+P E + + Y+ + ++ G++++E+ Sbjct: 170 LAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQ-YDVKSEIYSFGIVLWEI 228 Query: 233 AAGYPPFFADQPIQIYEKIVSGKVRFP--SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 290 A G PF +I + + + + P S+L++++ D + R V+ Sbjct: 229 ATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVR-----PSVD 283 Query: 291 DIKN 294 +I Sbjct: 284 EILK 287 >5USZ-A nrPDB Length = 289 Score = 136 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 109/269 (40%), Gaps = 24/269 (8%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGN-------HFAMKILDKQKVVKLKQIEHTLNEKR 94 + ++LG G+F ++ +E G+ +K+LDK E Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK---AHRNYSESFFEAAS 64 Query: 95 ILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-FSEPHARFYAAQIVL 153 ++ ++ LV +V E+V G + ++L++ + A Q+ Sbjct: 65 MMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAA 124 Query: 154 TFEYLHSLDLIYRDLKPENLLI--------DQQGYIQVTDFGFAKRVKGRTWTLCGTPEY 205 +L LI+ ++ +N+L+ +I+++D G + V + P + Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIP-W 183 Query: 206 LAPEIILS-KGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSGKVRFPSHFS 263 + PE I + K N A D W+ G ++E+ + G P A + + + + P+ + Sbjct: 184 VPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQ-FYEDRHQLPAPKA 242 Query: 264 SDLKDLLRNLLQVDLTKRFGNLKNGVNDI 292 ++L +L+ N + + R + + + D+ Sbjct: 243 AELANLINNCMDYEPDHR-PSFRAIIRDL 270 >5C01-A nrPDB Length = 342 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 51/244 (20%), Positives = 90/244 (36%), Gaps = 19/244 (7%) Query: 61 VKHKETGNHFAMKILDKQKVVKLKQIEHTLNE-KRILQAVNFPFLVKLEYSFKDNSNLYM 119 + + +K+LD I E ++ V+ L + M Sbjct: 101 GRDRGQELRVVLKVLDPSH----HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIM 156 Query: 120 VMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ 178 V EYV G + LRR G A Q+ YL + +L++ ++ N+L+ + Sbjct: 157 VTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 216 Query: 179 G-------YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK--GYNKAVDWWALGVLI 229 G +I+++D G R + P +LAPE + + A+D W G + Sbjct: 217 GLAEGTSPFIKLSDPGVGLGALSREERVERIP-WLAPECLPGGANSLSTAMDKWGFGATL 275 Query: 230 YEMAA-GYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNG 288 E+ G P + P + E + R P L L L + T+R + + Sbjct: 276 LEICFDGEAPLQSRSPSEK-EHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR-PSFRTI 333 Query: 289 VNDI 292 + D+ Sbjct: 334 LRDL 337 >2PZI-A nrPDB Length = 681 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 103/264 (39%), Gaps = 35/264 (13%) Query: 43 QFERIKTLGTGSFGRVMLVKHKE-TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 Q+E + G G + L + G +K L + + + + L V Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFLAEVVH 138 Query: 102 PFLVKLEYSFKDNSNL-----YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 P +V++ + Y+VMEYV G + + + A Y +I+ Sbjct: 139 PSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPALS 196 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGY 216 YLHS+ L+Y DLKPEN+++ ++ +++ D G R+ + L GTP + APEI+ + Sbjct: 197 YLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY-LYGTPGFQAPEIVRTGP- 253 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSHFSSDLKD------ 268 A D + +G + + P +G+ P LK Sbjct: 254 TVATDIYTVGRTLAALTLDLP-------------TRNGRYVDGLPED-DPVLKTYDSYGR 299 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDI 292 LLR + D +RF + + Sbjct: 300 LLRRAIDPDPRQRFTTAEEMSAQL 323 >4WOV-A nrPDB Length = 317 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 51/244 (20%), Positives = 90/244 (36%), Gaps = 19/244 (7%) Query: 61 VKHKETGNHFAMKILDKQKVVKLKQIEHTLNE-KRILQAVNFPFLVKLEYSFKDNSNLYM 119 + + +K+LD I E ++ V+ L + M Sbjct: 78 GRDRGQELRVVLKVLDPSH----HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIM 133 Query: 120 VMEYVPGGEMFSHLRR-IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ 178 V EYV G + LRR G A Q+ YL + +L++ ++ N+L+ + Sbjct: 134 VTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 193 Query: 179 G-------YIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK--GYNKAVDWWALGVLI 229 G +I+++D G R + P +LAPE + + A+D W G + Sbjct: 194 GLAEGTSPFIKLSDPGVGLGALSREERVERIP-WLAPECLPGGANSLSTAMDKWGFGATL 252 Query: 230 YEMAA-GYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNG 288 E+ G P + P + E + R P L L L + T+R + + Sbjct: 253 LEICFDGEAPLQSRSPSEK-EHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR-PSFRTI 310 Query: 289 VNDI 292 + D+ Sbjct: 311 LRDL 314 >4Y12-A nrPDB Length = 375 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 103/264 (39%), Gaps = 35/264 (13%) Query: 43 QFERIKTLGTGSFGRVMLVKHKE-TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 Q+E + G G + L + G +K L + + + + L V Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFLAEVVH 177 Query: 102 PFLVKLEYSFKDNSNL-----YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 P +V++ + Y+VMEYV G + + + A Y +I+ Sbjct: 178 PSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPALS 235 Query: 157 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGY 216 YLHS+ L+Y DLKPEN+++ ++ +++ D G R+ + L GTP + APEI+ + Sbjct: 236 YLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY-LYGTPGFQAPEIVRTGP- 292 Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSHFSSDLKD------ 268 A D + +G + + P +G+ P LK Sbjct: 293 TVATDIYTVGRTLAALTLDLP-------------TRNGRYVDGLPED-DPVLKTYDSYGR 338 Query: 269 LLRNLLQVDLTKRFGNLKNGVNDI 292 LLR + D +RF + + Sbjct: 339 LLRRAIDPDPRQRFTTAEEMSAQL 362 >2QLU-A nrPDB Length = 314 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 54/291 (18%), Positives = 104/291 (35%), Gaps = 59/291 (20%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQ--AVNF 101 + ++ G FG V + + A+KI L+ + +E+ I + Sbjct: 17 LQLLEIKARGRFGCVWKAQ--LMNDFVAVKIFP------LQDKQSWQSEREIFSTPGMKH 68 Query: 102 PFLVKLEYSFKDNSNL----YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 157 L++ + K SNL +++ + G + +L + + A + Y Sbjct: 69 ENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSRGLSY 127 Query: 158 LHS-----------LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-----GRTWTLCG 201 LH + +RD K +N+L+ + DFG A R + G T G Sbjct: 128 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG 187 Query: 202 TPEYLAPEIILS-----KGYNKAVDWWALGVLIYEMAAGY-----------PPFFAD--- 242 T Y+APE++ + +D +A+G++++E+ + PF + Sbjct: 188 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ 247 Query: 243 --QPIQIYEKIVSGKVRFP--SHF--SSDLKDL---LRNLLQVDLTKRFGN 284 ++ E +V K+R H+ L L + D R Sbjct: 248 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >5X1R-A nrPDB Length = 302 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 48/280 (17%), Positives = 97/280 (34%), Gaps = 34/280 (12%) Query: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQ-------------- 85 ++FE + +G G FG V + A+K + K Sbjct: 19 RFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKT 78 Query: 86 ----IEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSH-LRRIGRFS 140 + + E R+L + P L+ + +++N YM ++ G + + ++ + Sbjct: 79 FQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKID 138 Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTW 197 E R + +H ++RD+ +N+ I + + DFG A++ G Sbjct: 139 EAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDET 198 Query: 198 TLCGTPEYLAPEII---LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254 + P + E D +ALG +++ + G PP P+ + I Sbjct: 199 EIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVRSIEDS 253 Query: 255 ----KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 290 R P+ +S +L + L + R + Sbjct: 254 YQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAE 293 >4JRN-A nrPDB Length = 372 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 52/275 (18%), Positives = 91/275 (33%), Gaps = 44/275 (16%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-------- 100 LG+G F V ET A+K+ +K + + E + + Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 101 ---FPFLVKLEYSFKDNSN------LYMVMEYVPG---------GEMFSHLR-------- 134 F+V + + + + +VP +M + Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 135 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG 194 F + ++Q + + + +++ D+KP N L+ + G + + DFG R+ Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG-TYRINN 253 Query: 195 RTWTLCGTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 251 GTP Y PE Y D W LG+ +Y + P AD Sbjct: 254 SVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLH-- 311 Query: 252 VSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLK 286 ++DL+R+LL D KR L+ Sbjct: 312 ----FADCPSTPELVQDLIRSLLNRDPQKRMLPLQ 342 >5J0A-A nrPDB Length = 300 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 43/214 (20%), Positives = 83/214 (38%), Gaps = 26/214 (12%) Query: 48 KTLGTGSFGR---VMLVKHKETGNH---FAMKILDKQKVVKLKQI--EHTLNEKRILQAV 99 + LG FG V L+K G +A+K ++ + + + ++E +IL+++ Sbjct: 15 QKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL 71 Query: 100 NFPFLVKLEYSFK-DNSNLYMVMEYVPGGEMFSHLRRI-----GRFSEPHARFYAAQIVL 153 + P +V + ++ +L + MEY + + F A + Sbjct: 72 HHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMAR 131 Query: 154 TFEYLHS-LDLIYRDLKPENLLIDQQG-YIQVTDFGFA------KRVKGRTWTLCGTPEY 205 +YLH L++ D+K N++I I++ D G + V GT + Sbjct: 132 GLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPW 191 Query: 206 LAPEIILSKGY-NKAVDWWALGVLIYEMAAGYPP 238 E + G D +A G+ ++EM P Sbjct: 192 KPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP 225 >5OAT-A nrPDB Length = 411 Score = 123 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 115/309 (37%), Gaps = 63/309 (20%) Query: 36 QNTAHLDQFERIKTLGTGSFGRVM--LVKHKETGNH---FAMKILDKQKVVK--LKQIEH 88 N L+ K + G+ G V VK ET ++ FA+K++ + + ++ ++ Sbjct: 5 SNPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKA 64 Query: 89 TLNE---KRIL---QAVN---------------FPFLVKLEYSFKDNSNLYMVMEYVPGG 127 E R+ +N P +V + F D + P G Sbjct: 65 MYRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEG 124 Query: 128 -----EMFSHLRRIG---------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENL 173 +F ++R S + AQ++ ++ + + +RDLK +NL Sbjct: 125 EGRNMSLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNL 184 Query: 174 LID----QQGYIQVTDFG---------FAKRVKGRTWTLCGTPEYLAPEIILSKG----- 215 L+D + + ++DFG + G +APEII K Sbjct: 185 LLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSV 244 Query: 216 --YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 Y+ D WA+G + YE+ + PF+ ++ + + P + ++ L+ NL Sbjct: 245 LNYS-KADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVANL 303 Query: 274 LQVDLTKRF 282 L+ + KR Sbjct: 304 LKRNPNKRL 312 >4I94-A nrPDB Length = 300 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 43/234 (18%), Positives = 84/234 (35%), Gaps = 14/234 (5%) Query: 57 RVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSN 116 V K E A+K +++ +Q L E + + + + L ++ Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSRQ---FLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHA--RFYAAQIVLTFEYLHSLD-LIYRDLKPENL 173 ++ E++P + HL A A I EY S +Y DL + Sbjct: 100 RLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 174 LIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA 233 L D +++ FG K + + + PE + + ++ G L+ ++ Sbjct: 160 LFDDDANPRLSCFGLMKNSRDG-KSYSTNLAFTPPEYLRTGRVTPESVIYSFGTLLLDLL 218 Query: 234 AGY--PPFFADQPI--QIYEKIVSGKVR--FPSHFSSDLKDLLRNLLQVDLTKR 281 +G PP A I + + ++ + F S ++L L LQ + +R Sbjct: 219 SGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRER 272 >6EQI-C nrPDB Length = 433 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 55/321 (17%), Positives = 106/321 (33%), Gaps = 77/321 (23%) Query: 39 AHLDQFERIKTLGTGSFGRVMLVKHKETG-----NHFAMKILDKQKVVKLKQ--IEHTLN 91 A+LD+ + + + G V K K + A+K++ V ++ Sbjct: 12 ANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYR 71 Query: 92 E---------------KRILQAVN-----FPFLVKLEYSFKD------------------ 113 E + P +V++ F D Sbjct: 72 ETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPP 131 Query: 114 ---------NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLI 164 N +L++VM+ + +LR + + +Q++ +++ ++ Sbjct: 132 RINPEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP-NMRSSILLLSQLLEAVAHMNIHNIS 189 Query: 165 YRDLKPENLLIDQQ-----GYIQVTDF---------GFAKRVKGRTWTLCGTPEYLAPEI 210 +RDLK +N+L+D I +TDF G + G +APEI Sbjct: 190 HRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEI 249 Query: 211 ILSKGYN------KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV-RFPSHFS 263 +K K D WA+G + YE+ PF+ + + + P Sbjct: 250 ANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPELPDTIP 309 Query: 264 SDLKDLLRNLLQVDLTKRFGN 284 +++L+ N+L KR Sbjct: 310 FIIRNLVSNMLSRSTNKRLDC 330 >5UV4-A nrPDB Length = 311 Score = 104 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 42/204 (20%), Positives = 73/204 (35%), Gaps = 19/204 (9%) Query: 48 KTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + +G G + G +K L + K+ E + L +V P LV L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKE---FSREIKKLGSVRHPNLVPL 86 Query: 108 --EYSFKDNSNLYMVMEYVPGGEMFSHL-----RRIGRFSEPHARFYAAQIVLTFEYLHS 160 Y M+ +Y + ++L R + S A I +YLH+ Sbjct: 87 RGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHN 146 Query: 161 LDLI-YRDLKPENLLI-DQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSK 214 +I + ++K N+LI + VTD+ + + G Y PE + Sbjct: 147 ERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTS 206 Query: 215 GY--NKAVDWWALGVLIYEMAAGY 236 + D +A GV++ E+ G Sbjct: 207 KPCPSLKSDVYAFGVILLELLTGK 230 >4L68-A nrPDB Length = 340 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 36/191 (18%), Positives = 67/191 (35%), Gaps = 16/191 (8%) Query: 56 GRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNS 115 G G+ A+K L K+ + + E L + L L Sbjct: 54 GTTYKA-LLPDGSALAVKHLSTCKLGERE----FRYEMNQLWELRHSNLAPLLGFCVVEE 108 Query: 116 NLYMVMEYVPGGEMFSHL-RRIGRFSEPHARFYAAQIVLTFEYLHS---LDLIYRDLKPE 171 ++V +Y+ G + S L G +LH ++++++ Sbjct: 109 EKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSS 168 Query: 172 NLLIDQQGYIQVTDFGFAKRVKGRTWTLC-------GTPEYLAPEIILSKGYNKAVDWWA 224 +LID+ ++ D G A+ + G Y+APE + + D + Sbjct: 169 VILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYG 228 Query: 225 LGVLIYEMAAG 235 LGV++ E+A G Sbjct: 229 LGVVLLELATG 239 >6J6I-B nrPDB Length = 351 Score = 100 bits (250), Expect = 9e-22, Method: Composition-based stats. Identities = 28/183 (15%), Positives = 66/183 (36%), Gaps = 15/183 (8%) Query: 70 FAMKILDKQKVVKLKQIEHTLNEKRIL--QAVNFPFLVKLEYSFKDNSNLYMVMEYVPGG 127 + +K + ++ + + +L + N ++L + +V E+ G Sbjct: 84 YMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAEHG 143 Query: 128 EMFSH---LRRIGR--FSEPHARFYAAQIVLTFEYLHS---LDLIYRDLKPENLLIDQQG 179 M + +I YLH+ +I+RD+KP ++ +D+ Sbjct: 144 AMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNW 203 Query: 180 YIQVTDFGFAKRVKGRTWT-----LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA 234 +++D F+ + + GT Y+ P + + D ++ G+ + + Sbjct: 204 TAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIIT 263 Query: 235 GYP 237 G P Sbjct: 264 GKP 266 >5UU1-A nrPDB Length = 324 Score = 98.4 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 42/231 (18%), Positives = 85/231 (36%), Gaps = 34/231 (14%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFA---MKILDKQKVVKLKQIEHTLN------- 91 +Q+ K +G+G FG + L A +K+ ++ +++ Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 75 Query: 92 ----EKRILQAVNFPFLVKLEYS----FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143 E++ L + P S FK S +MVME + G ++ + G F + Sbjct: 76 KKWIERKQLDYLGIP---LFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKKST 131 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID--QQGYIQVTDFGFAKRV--------- 192 +++ EY+H + ++ D+K NLL+ + + D+G + R Sbjct: 132 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQY 191 Query: 193 -KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 242 + GT E+ + + ++ D LG + G P+ + Sbjct: 192 QENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 242 >5CLR-A nrPDB Length = 451 Score = 93.0 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 40/208 (19%), Positives = 81/208 (38%), Gaps = 23/208 (11%) Query: 59 MLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSN-- 116 V + G + +K + + + + NEK L + +L +F + Sbjct: 96 FKVYALDDGKTYFLKSVK----IDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQV 146 Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSE-----PHARFYAAQIVLTFEYLHSLDLIYRDLKPE 171 Y++ ++ G ++ + + + + + H L LI+RDLKP Sbjct: 147 HYILTTFIKGIDLSRY-KNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPG 205 Query: 172 NLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG---YNKAVDWWALGVL 228 N+++D + DFG + K GT YLAPE+ + +++ D +AL Sbjct: 206 NIMLDADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYS 265 Query: 229 IYEMAAGYPPFFADQPIQIYEKIVSGKV 256 + E+ PF + ++ I + + Sbjct: 266 LDELFN---PFRQVKFAKVDIGIKNKHL 290 >2RSV-A nrPDB Length = 403 Score = 90.3 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 45/268 (16%), Positives = 98/268 (36%), Gaps = 49/268 (18%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHF------AMKILDK------------QKVVKL 83 +++ +G G FG + L + +K+ Q+ K Sbjct: 42 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 100 Query: 84 KQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSN----LYMVMEYVPGGEMFSHLRRI--G 137 +QI+ + ++ L+ + P K S + N +M+M+ G + Sbjct: 101 EQIQKWIRTRK-LKYLGVP---KYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYEANAK 154 Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID--QQGYIQVTDFGFAKRV--- 192 RFS + +I+ EY+H + ++ D+K NLL++ + + D+G A R Sbjct: 155 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 214 Query: 193 -------KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 245 + GT E+ + + ++ D LG + + G+ P+ + + Sbjct: 215 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDNL 272 Query: 246 QIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 + + + K+R+ + L+ Sbjct: 273 KDPKYVRDSKIRYRENI----ASLMDKC 296 >2LAV-A nrPDB Length = 361 Score = 89.5 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 45/268 (16%), Positives = 98/268 (36%), Gaps = 49/268 (18%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHF------AMKILDK------------QKVVKL 83 +++ +G G FG + L + +K+ Q+ K Sbjct: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 Query: 84 KQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSN----LYMVMEYVPGGEMFSHLRRI--G 137 +QI+ + ++ L+ + P K S + N +M+M+ G + Sbjct: 94 EQIQKWIRTRK-LKYLGVP---KYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYEANAK 147 Query: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID--QQGYIQVTDFGFAKRV--- 192 RFS + +I+ EY+H + ++ D+K NLL++ + + D+G A R Sbjct: 148 RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 Query: 193 -------KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 245 + GT E+ + + ++ D LG + + G+ P+ + + Sbjct: 208 GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--EDNL 265 Query: 246 QIYEKIVSGKVRFPSHFSSDLKDLLRNL 273 + + + K+R+ + L+ Sbjct: 266 KDPKYVRDSKIRYRENI----ASLMDKC 289 >6EAS-A nrPDB Length = 308 Score = 81.1 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 51/253 (20%), Positives = 89/253 (35%), Gaps = 35/253 (13%) Query: 53 GSFGRVMLVKHK-ETGNHFAMK--ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEY 109 GS ML K +G A+ ++ K + + L V+ + L Sbjct: 49 GSTSTCMLYKGTLSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLG 108 Query: 110 SFKDNSNL--YMVMEYVPGGEMFSHL--RRIGRFSEPHARFYAAQIVLTFEYLHSLDL-- 163 ++ MV EY P G +F HL R + + I E++H L Sbjct: 109 YCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPA 168 Query: 164 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAP--EIILSKGYNKAVD 221 R+ + + +V+D F KG T + +P E I+ K Sbjct: 169 ALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELAF-SPDMEDIVRK------- 220 Query: 222 WWALGVLIYEMAAGYPP-FFADQPIQIY-EKIVSGKVR-----------FPSHFSSDLKD 268 G+++ E+ G P D P++ + + G +R FP + L + Sbjct: 221 ---YGMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCE 277 Query: 269 LLRNLLQVDLTKR 281 ++R+ + D KR Sbjct: 278 VVRSCIDRDPKKR 290 >6G4J-A nrPDB Length = 315 Score = 79.1 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 83/235 (35%), Gaps = 45/235 (19%) Query: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101 + + K LG G+ G V L + + H A+K+ D + +E +L++ + Sbjct: 26 NTYTLRKQLGKGANGIVYLAE--TSDGHVALKVSDDSLSIT--------SEVNVLKSFSK 75 Query: 102 PFLVKLEYSFKDNSNLYM----------VMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151 V + SF D + Y+ MEY+ G + ++ G Q+ Sbjct: 76 AQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIPVLMIQL 132 Query: 152 VLTFEYLHSLDLIYRDLKPEN-LLIDQQGYIQVTDFGFA----------KRVKGRTWTLC 200 + + LH I+ DLKP+N ++ I+ D G R + Sbjct: 133 LSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGY 192 Query: 201 GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255 GT + Y D +A+ +++ +QP + ++ G Sbjct: 193 GTRK-------AEPSY----DLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIEGN 236 >4O1O-A nrPDB Length = 717 Score = 77.6 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 89/251 (35%), Gaps = 52/251 (20%) Query: 67 GNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVP 125 A+K + + E LQ+ +V S D S L++ + Sbjct: 369 DQEVAVKRFSEGSTRGQQ-------EVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCE 421 Query: 126 GGEMFSHLRRIGRFSEPH-----ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180 + HL + P+ AR + + LH ++DL+P+N+LID + Sbjct: 422 Y-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNG 480 Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG-VLIYEMAAGYPPF 239 + DF + + P+ I D ALG +++Y + G F Sbjct: 481 TFLADFDKSIKWAED------------PQKIKR-------DLEALGLLVLYVVKKGDISF 521 Query: 240 FADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV--DLTKRFGNLKNGVNDIKNHKW 297 + Q +E+++ G + +DL+ +L ++ R + + H + Sbjct: 522 ETLKN-QSFEEVIQGSPD------EETRDLIHHLFHPGDNVEDRLSS-------LLAHPF 567 Query: 298 FATTDWIAIYQ 308 F W + Y+ Sbjct: 568 F--WSWESRYR 576 >5DMZ-A nrPDB Length = 365 Score = 77.2 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 38/243 (15%), Positives = 86/243 (35%), Gaps = 44/243 (18%) Query: 30 KWENPAQNTAHLDQFERIKTL-------GTGSFGRVMLVK-----HKETGNHFAMKILDK 77 +W+ +F+ L G G+F +V + F +K+ Sbjct: 46 EWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKV--- 102 Query: 78 QKVVKLKQIEHTLNEKRILQAVN----FPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHL 133 K ++++ + F +K + + +V E G + + + Sbjct: 103 ---QKPANPWEFYIGTQLMERLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAI 158 Query: 134 RRIGRFSEP-----HARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ----------- 177 E +A +++ E +H ++I+ D+KP+N ++ Sbjct: 159 NLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDL 218 Query: 178 QGYIQVTDFGFAKRV----KGRTWTL-CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232 + + D G + + KG +T C T + E++ +K +N +D++ + +Y M Sbjct: 219 SAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCM 278 Query: 233 AAG 235 G Sbjct: 279 LFG 281 >6BHC-A nrPDB Length = 438 Score = 73.8 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 100/268 (37%), Gaps = 55/268 (20%) Query: 64 KETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF------------ 111 K+ N++A+KI K K + +Q H+L ++ L + + F Sbjct: 80 KDPLNNYAVKIC-KSKAKESQQYYHSLAVRQSLAV--HFNIQQDCGHFLAEVPNRLLPWE 136 Query: 112 ----KDNSNLYMVMEYVPGGEMFSHLR-------RIGRFSEPHARFYAAQIVLTFEYLHS 160 K S++ ++ VP + +R + E Q+ E+L Sbjct: 137 DPSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKP 196 Query: 161 LDLIYRDLKPENLLIDQ---------------------QGYIQVTDFGFAKR---VKGRT 196 + + DL+ ENLL+ + V++F AK+ + Sbjct: 197 YHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPE 256 Query: 197 WTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV 256 + LAPEII + Y K D + G+LIYEM PF + ++ E + Sbjct: 257 ILRDQSR--LAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLP 313 Query: 257 RFP--SHFSSDLKDLLRNLLQVDLTKRF 282 R P S +S L+ L LL + ++R Sbjct: 314 RIPFRSPYSRGLQQLASCLLNPNPSERI 341 >6EWX-A nrPDB Length = 484 Score = 69.9 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 46/223 (20%), Positives = 75/223 (33%), Gaps = 53/223 (23%) Query: 112 KDNSNLYMVMEYVPGGEMFSHLRRI-------GRFSEPHARFYAAQIVLTFEYLHSLDLI 164 ++ + ++ VP +R E F Q+ E+L +I Sbjct: 173 QEQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGII 232 Query: 165 YRDLKPENLLIDQQG-----------------------------------------YIQV 183 +RDL ENLL+ + + Sbjct: 233 HRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLII 292 Query: 184 TDFGFAKRVKGRTWTL--CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA 241 ++F AK+ G T L + LAPEI+ + Y + D + G+LIYE+ PF Sbjct: 293 SNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY-RKFDEFQTGILIYELLHQPNPFEV 351 Query: 242 DQPIQIYEKIVSGKVRFP--SHFSSDLKDLLRNLLQVDLTKRF 282 ++ + P S +S L+ L LL+ D KR Sbjct: 352 RAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRI 394 >4IX6-A nrPDB Length = 350 Score = 69.5 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 54/328 (16%), Positives = 97/328 (29%), Gaps = 90/328 (27%) Query: 49 TLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF----L 104 LG+G+FG V K + L K + E E + V Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV-HANAKGTC 81 Query: 105 VKLEYSFK----DNSNLY--MVME---YV---PGGEMFSHLRRIGRFSEPHA-------- 144 + + D +Y + E + G L R G A Sbjct: 82 ARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATE 141 Query: 145 ----RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ--GYIQVTDFGFAKR---VKGR 195 + +++ + LH +++RD+KP NL+ ++ G +++ D G A + Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPET 201 Query: 196 TWTLCG----TPEY--------LAP--------------EIILSKGYNKAVDWWALGVLI 229 G P Y L P E ++ W+ G ++ Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS----WSAGCVM 257 Query: 230 YEMAA-------GYPPFFAD-----QPIQIYEKIVSGKVRFPSHFSSDL-----KDLLRN 272 ++A G F AD + + SG+ + D DL + Sbjct: 258 LQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGWDLCQR 317 Query: 273 LLQVDLTKRFGNLKNGVNDIKNHKWFAT 300 L++ + R +H +F Sbjct: 318 LMEAERDAR-----ASCEAALSHAFFDA 340 >4OAU-C nrPDB Length = 699 Score = 66.8 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 79/239 (33%), Gaps = 45/239 (18%) Query: 67 GNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVN-FPFLVKLEYSFKDNSNLYMVMEYVP 125 A+K + E LQ+ LV S +L++ + Sbjct: 366 KQEVAVKTFCEGSP-------RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE 418 Query: 126 -GGEMFSHLRRIGRFSEPH---ARFYAAQIVLTFEYLH-SLDLIYRDLKPENLLIDQQGY 180 E + R AR + I + LH S ++DL+P+N+LID + Sbjct: 419 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 478 Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALG-VLIYEMAAGYPPF 239 + DF + + G + D LG +++Y + G F Sbjct: 479 AHLADFDKSIKWAGDPQEV-------------------KRDLEDLGRLVLYVVKKGSISF 519 Query: 240 FADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 298 + E + ++ + KDL+ L ++++ ++D+ H +F Sbjct: 520 EDLKAQSNEEVV---QLSP----DEETKDLIHRLFHP-----GEHVRDCLSDLLGHPFF 566 >6M7Z-A nrPDB Length = 319 Score = 66.4 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 45/302 (14%), Positives = 96/302 (31%), Gaps = 58/302 (19%) Query: 46 RIKTLGTGSFGRVMLVKHKETGNHF---AMKILDKQKVVKLKQIEHTLNEKRILQAVNFP 102 +K L +GSF L + T + A +++ + +Q E + R++ ++ Sbjct: 34 ILKRLLSGSF----LRRDGSTTVNVRVPARELVRLLSLTPEQQREGVSAKVRLINLLDPK 89 Query: 103 FLVK----LEYSFKDNSNLYM-------------VMEYVPGGEMFSHLRRIGRFSEPHAR 145 + V S L + + + G + L S P + Sbjct: 90 YSVYEPYLYREILPKRSPLLLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGR--SHPDVQ 147 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---- 201 AA +V + LH+L L++R ++ + + G + + A + T G Sbjct: 148 VLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFFGQ 207 Query: 202 -TPEYLAPEI---------ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 251 T APEI + + D ++LGV + + + + Sbjct: 208 ET----APEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLV--QLLGNGNLGPEDRGAV 261 Query: 252 VSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKV 311 + S + +++ + R + +I F ++ I + K Sbjct: 262 RQDHLELLDKLS-------QKMIEEEPGNR-----PTIEEIMKDPLFEGLNFEDIEEGKA 309 Query: 312 EA 313 Sbjct: 310 RP 311 >2JII-A nrPDB Length = 352 Score = 64.9 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 28/147 (19%), Positives = 63/147 (42%), Gaps = 15/147 (10%) Query: 107 LEYSFKDNSNLYMVMEYVPGGEMFSHL--RRIGRFSEPHARFYAAQIVLTFEYLHSLDLI 164 + + + ++V+ + G + S L SE A +++ E+LH + + Sbjct: 123 MGFGVHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 181 Query: 165 YRDLKPENLLID--QQGYIQVTDFGFAKR----------VKGRTWTLCGTPEYLAPEIIL 212 + ++ EN+ +D Q + + +GFA R V+G G E+++ ++ Sbjct: 182 HGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHK 241 Query: 213 SKGYNKAVDWWALGVLIYEMAAGYPPF 239 G ++ D +LG + + G+ P+ Sbjct: 242 GCGPSRRSDLQSLGYCMLKWLYGFLPW 268 >4CI6-B nrPDB Length = 643 Score = 63.0 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 41/226 (18%), Positives = 81/226 (35%), Gaps = 40/226 (17%) Query: 64 KETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAV-----NFPFLVKLEY--SFKDNSN 116 K+ A K+ + H E + + P L + + Sbjct: 66 KDKQRLVA-------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNR 118 Query: 117 LY--MVMEYVPG-------GEMFSHLRRIGRFSEP---HARFYAAQIVLTFEYLHSLDLI 164 Y ++M+ V G + ++ SE +F A +++ +L ++ Sbjct: 119 YYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIV 178 Query: 165 YRDLKPENLLIDQ-QGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEI-ILSKGYNKAVDW 222 + D+KP N++ D+ G V D G R + T + APE+ + + G ++ D Sbjct: 179 HNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGF--TESFKAPELGVGNLGASEKSDV 236 Query: 223 WALGVLIYEMAAGYPPFFAD---QPIQIYEKIVSGKVRFPSHFSSD 265 + +++ + G F D +P Q I S P+H + Sbjct: 237 F---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSE----PAHVMDE 275 >5GZ9-A nrPDB Length = 305 Score = 61.4 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 45/211 (21%), Positives = 79/211 (37%), Gaps = 41/211 (19%) Query: 45 ERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFL 104 ++K +G G+ RV L + KE + A+ ++ +L+ E L+ ++L+++ + Sbjct: 37 RQLKRVGEGAVKRVFLSEWKE--HKVAL-----SRLTRLEMKEDFLHGLQMLKSLQSEHV 89 Query: 105 VKLEYSFKDNSNLYMVMEYVPGGEM------FSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 V L +++ ++ EY P G + + + H A + V YL Sbjct: 90 VTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYL 147 Query: 159 HSLDLIYRDLKPEN--------LLIDQQGYIQVTDFGFAKRVKGRTWTL--CGTPE---- 204 H L R + N L+ I D V + L CG E Sbjct: 148 HHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGD 207 Query: 205 YLAPEII------------LSKGYNKAVDWW 223 ++APE + L YN+ VD W Sbjct: 208 FVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >5GZA-A nrPDB Length = 290 Score = 59.5 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 44/210 (20%), Positives = 74/210 (35%), Gaps = 40/210 (19%) Query: 45 ERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFL 104 R+K +G G+ +V L + + G A+ +L + L+ +L+A+ + Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLSSDQYAD-----DFLHGLSMLRALQSSHV 80 Query: 105 VKLEYSFKDNSNLYMVMEYVPGGEMFSHL------RRIGRFSEPHARFYAAQIVLTFEYL 158 V L ++++ V EY P G + + R R S A V YL Sbjct: 81 VTLVGVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYL 138 Query: 159 HSLDLIYRDLKPEN--------LLIDQQGYIQVTDF-GFAKRVKGRTWTLCG----TPEY 205 HS R + N L+ + D + KG CG T ++ Sbjct: 139 HSSPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDF 198 Query: 206 LAPEII------------LSKGYNKAVDWW 223 +APE + GY++ D W Sbjct: 199 VAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >3BYV-A nrPDB Length = 377 Score = 57.2 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 98/247 (39%), Gaps = 37/247 (14%) Query: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF---LVK------LEYSFKDNSNLYMVM 121 A+K + K++V++L+ + N+K+ + F F LVK + D +++++ Sbjct: 116 AIKQM-KEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLS 174 Query: 122 EYVPGGEMFSHLRRIGRFSEPHA-----------RFYAAQIVLTFEYLHSLDLIYRDLKP 170 + M S+L+ G H+ Q++ LH L++ L+P Sbjct: 175 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRP 234 Query: 171 ENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEI------ILSKG-----YNKA 219 ++++DQ+G + +T F R R + + + PE+ I + Sbjct: 235 VDIVLDQRGGVFLTGFEHLVRDGARVVSSV-SRGFEPPELEARRATISYHRDRRTLMTFS 293 Query: 220 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLT 279 D WALG++IY + P D + E I R + ++ LL L+ Sbjct: 294 FDAWALGLVIYWIWCADLPITKDAALGGSEWI----FRSCKNIPQPVRALLEGFLRYPKE 349 Query: 280 KRFGNLK 286 R L+ Sbjct: 350 DRLLPLQ 356 >3DZO-A nrPDB Length = 413 Score = 56.0 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 94/246 (38%), Gaps = 36/246 (14%) Query: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF---LVK------LEYSFKDNSNLYMVM 121 A+K + K++V++L+ + N+K+ + F F LVK + D +++++ Sbjct: 121 AIKQM-KEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLS 179 Query: 122 EYVPGGEMFSHLRRIGRFSEPHA-----------RFYAAQIVLTFEYLHSLDLIYRDLKP 170 + M S+L+ G H+ Q++ LH L++ L+P Sbjct: 180 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRP 239 Query: 171 ENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKG----------YNKAV 220 ++++DQ+G + +T F R + G + PE + A Sbjct: 240 VDIVLDQRGGVFLTGFEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAF 298 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 280 D W LG+ IY + P D + E I R + ++ LL L+ Sbjct: 299 DTWTLGLAIYWIWCADLPNTDDAALGGSEWI----FRSCKNIPQPVRALLEGFLRYPKED 354 Query: 281 RFGNLK 286 R L+ Sbjct: 355 RLLPLQ 360 >2W1Z-A nrPDB Length = 368 Score = 54.9 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 87/246 (35%), Gaps = 36/246 (14%) Query: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV---------KLEYSFKDNSNLYMVM 121 A+K L +Q V++L+ + N+++ + F F + K+ D +++++ Sbjct: 101 AIKQLSEQ-VLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLS 159 Query: 122 EY-----------VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKP 170 + + G + SH Q++ L L++ D + Sbjct: 160 RFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQV 219 Query: 171 ENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK--GY--------NKAV 220 N+L+DQ+G + +T F R + G + PE + Y Sbjct: 220 RNILLDQRGGVFLTGFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPF 278 Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTK 280 D W LG+ IY + P D + E I R + ++ LL L+ Sbjct: 279 DTWTLGLAIYWIWCADLPNTEDAELGGIEWI----YRRCKNIPQPVRALLEGFLRYSKED 334 Query: 281 RFGNLK 286 R L+ Sbjct: 335 RLLPLQ 340 >4CZY-B nrPDB Length = 429 Score = 54.9 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 87/234 (37%), Gaps = 40/234 (17%) Query: 59 MLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNE-KRILQAVNFPFLVKLEYSFKD---- 113 ++ + G HFA++ ++ ++ K I + E K+I+ A +V + +F Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEWKKIINA----NIVTVHEAFTTEFFG 116 Query: 114 NSNLYMVMEYVPGGE-MFSH----------LRRIGRFSEPHARFYAAQIVLTFEYLHSLD 162 +S+L V ++ P E ++ H LR + E Y QI +H+ Sbjct: 117 DSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAK 176 Query: 163 LIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDW 222 L R L+ + I + I++ A + + E + + + K Sbjct: 177 LAARCLELSKI-IWENNRIRLA----ACSILDVLHHDSPNRK--TIEELQQEDFVK---- 225 Query: 223 WALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276 G +I +A + P + I + +S+ L+ +L L++ Sbjct: 226 --FGRIILALAT-------NTPTLNFNNIDAALATIVPRYSTQLRGVLEWLIKP 270 >6G38-A nrPDB Length = 357 Score = 54.1 bits (129), Expect = 9e-08, Method: Composition-based stats. Identities = 36/190 (18%), Positives = 60/190 (31%), Gaps = 48/190 (25%) Query: 29 KKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQ-----KVVKL 83 +K P + ++ +R + +G G FG V T A+KI+ + Sbjct: 28 QKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQ 85 Query: 84 KQIEHTLNEKRILQA-----------------VNFPFLVKLEYS---------------- 110 K E L E I + +N V+ Y Sbjct: 86 KTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGS 145 Query: 111 ------FKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH-SLDL 163 F + L++V+E+ GG +R S A+ Q+ + SL Sbjct: 146 ANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLS-SLATAKSILHQLTASLAVAEASLRF 204 Query: 164 IYRDLKPENL 173 +RDL N+ Sbjct: 205 EHRDLHWGNV 214 >4AZV-A nrPDB Length = 569 Score = 53.7 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 32/70 (45%), Gaps = 3/70 (4%) Query: 118 YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ 177 ++VME +PG + L E ++ + L + D++P N+++D Sbjct: 318 WLVMEKLPGRLLSDMLAAGE---EIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDA 374 Query: 178 QGYIQVTDFG 187 + + ++ DFG Sbjct: 375 RQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 53.7 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 32/70 (45%), Gaps = 3/70 (4%) Query: 118 YMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ 177 ++VME +PG + L E ++ + L + D++P N+++D Sbjct: 318 WLVMEKLPGRLLSDMLAAGE---EIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDA 374 Query: 178 QGYIQVTDFG 187 + + ++ DFG Sbjct: 375 RQHARLIDFG 384 >4CYJ-A nrPDB Length = 438 Score = 53.0 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 27/147 (18%), Positives = 55/147 (37%), Gaps = 20/147 (13%) Query: 55 FGR---VMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSF 111 FG V ++ G H+A++ L + +L + LN + + + +V + F Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRL---EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVF 121 Query: 112 KD----NSNLYMVMEYVPGGEMF----------SHLRRIGRFSEPHARFYAAQIVLTFEY 157 +S+L ++ P + + R E Y QI + Sbjct: 122 TTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKT 181 Query: 158 LHSLDLIYRDLKPENLLIDQQGYIQVT 184 +HS L R L+P +++ I+++ Sbjct: 182 IHSNRLAARCLEPSKIILTDINRIRLS 208 >5VE6-A nrPDB Length = 492 Score = 49.9 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 18/35 (51%) Query: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI 175 E F Q+ E+L +I+RDL ENLL+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 46.0 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 24/79 (30%), Positives = 36/79 (45%), Gaps = 3/79 (3%) Query: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP--SHFS 263 LAPEI+ + Y + D + G+LIYE+ PF ++ + P S +S Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPALSLYS 383 Query: 264 SDLKDLLRNLLQVDLTKRF 282 L+ L LL+ D KR Sbjct: 384 PGLQQLAHLLLEADPIKRI 402 >4WWA-A nrPDB Length = 261 Score = 49.1 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 57/148 (38%), Gaps = 18/148 (12%) Query: 59 MLVKHKETGNHFAMKILDKQKVVKLKQIE-----HTLNEKRILQAVN-FPFLV--KLEYS 110 L + K++ + +K ++ + + TLNE R+L + P L +L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 111 FKDNSNLYMVM--EYVPGGEMFSHLRRIGRFSEPH-----ARFYAAQIVLTFEYLHSLDL 163 N +++ E +PGG FS+L+ + ++ LH D Sbjct: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDY 157 Query: 164 IYRDLKPENLLIDQQG---YIQVTDFGF 188 + DL N+++ + G + DFG Sbjct: 158 CHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >3Q60-A nrPDB Length = 371 Score = 47.6 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 33/157 (21%), Positives = 55/157 (35%), Gaps = 23/157 (14%) Query: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYL 206 AQ++ L S L++ P+NL I G + + D +V R Y Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPVTYA 258 Query: 207 APEIILSK--GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS---- 260 E + + + A++ W LG+ IY + + PF P + G + PS Sbjct: 259 PREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPG------IKGSWKRPSLRVP 312 Query: 261 -----------HFSSDLKDLLRNLLQVDLTKRFGNLK 286 +K L+ L D +R L+ Sbjct: 313 GTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLE 349 >5YK0-A nrPDB Length = 452 Score = 47.2 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 26/176 (14%), Positives = 54/176 (30%), Gaps = 40/176 (22%) Query: 56 GRVMLVKHKETGNHFAMKILDKQKVVKLK-QIEHTLNEKRILQAV----NFPFLVK---- 106 G+V G A+KI L+ ++ +L+ + + +V Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 107 -----------------LEYSFKDNSNL-----------YMVMEYVPGGEMFSHLRRIGR 138 ++ D+ ++ E++ G M +R Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 139 FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG 194 A++ F+ L L++ D P N ++ G + + DFG + G Sbjct: 265 EQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFGAVAPMPG 318 >3ENH-A nrPDB Length = 540 Score = 47.2 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 28/146 (19%), Positives = 53/146 (36%), Gaps = 17/146 (11%) Query: 50 LGTGSFGRVMLVKHKETGNHFAMK-ILDK----QKVVKLKQIEHTLNEKRILQAVNFPFL 104 +G G+ + + +K + K +++ + + T E R L V + Sbjct: 344 IGKGA--EADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 105 VKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLI 164 D N ++M Y+ G ++ + A +I LH D+I Sbjct: 402 PAPYIFDVDLDNKRIMMSYING--------KLAKDVIEDNLDIAYKIGEIVGKLHKNDVI 453 Query: 165 YRDLKPENLLIDQQGYIQVTDFGFAK 190 + DL N + D+ + + DFG K Sbjct: 454 HNDLTTSNFIFDKD--LYIIDFGLGK 477 >4BWP-A nrPDB Length = 448 Score = 44.9 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 21/166 (12%), Positives = 49/166 (29%), Gaps = 43/166 (25%) Query: 59 MLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKD----N 114 H TG + ++ + ++ K + + + + +V+L F + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTK----CMTLVEMWKKLQHTNVVQLREVFTTKAFGD 122 Query: 115 SNLYMVMEYVPG-----------------------GEMFSHLRRIG--------RFSEPH 143 ++L +V +Y PG GE + E Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ----GYIQVTD 185 Q+ + +H L + L P +++ + ++D Sbjct: 183 IWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >1TQM-A nrPDB Length = 282 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 32/168 (19%), Positives = 65/168 (38%), Gaps = 30/168 (17%) Query: 46 RIKTLGTGS-----------FGRVMLVKHKETGNHFAMKILDKQKVV-----KLKQIEHT 89 K +G G FG ++ HK F K + +++ + I Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSF--KKVKEKRDYGDLHFSVLAIRSA 151 Query: 90 LNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149 NE R LQ + + K+ +++ N+ ++ME + E++ R+ + Sbjct: 152 RNEFRALQKLQGLAVPKVY-AWEGNA---VLMELIDAKELY----RVRVENPDEVLDM-- 201 Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW 197 I+ + +++ DL N+L+ ++G I + DF + V W Sbjct: 202 -ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGEEGW 247 >6G18-v nrPDB Length = 552 Score = 37.5 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 29/75 (38%), Gaps = 8/75 (10%) Query: 113 DNSNLYMVMEYVPGGEMFSHLRRIGRFSE-PHARFYAAQIVLTFEYLHSLDLIYRDLKPE 171 D + +VME + G + S A ++ + LI+ D Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNEF 232 Query: 172 NLLIDQQGYIQVTDF 186 NL++D+ +I + DF Sbjct: 233 NLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 37.2 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 29/75 (38%), Gaps = 8/75 (10%) Query: 113 DNSNLYMVMEYVPGGEMFSHLRRIGRFSE-PHARFYAAQIVLTFEYLHSLDLIYRDLKPE 171 D + +VME + G + S A ++ + LI+ D Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNEF 232 Query: 172 NLLIDQQGYIQVTDF 186 NL++D+ +I + DF Sbjct: 233 NLILDESDHITMIDF 247 >4BVU-A nrPDB Length = 211 Score = 36.0 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 30/186 (16%), Positives = 59/186 (31%), Gaps = 30/186 (16%) Query: 46 RIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV 105 K +G GS + + + + K I + NE + Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY-----------KKYDLIGNQYNEILEMAWQESELFN 92 Query: 106 KLEY-----SFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 + ++Y+ M VPG + + Y I L+ Sbjct: 93 AFYGDEASVVIQYGGDVYLRMLRVPGTPLSDI--DTADIPDNIESLYLQLICK----LNE 146 Query: 161 LDLIYRDLKPENLLIDQQGY-IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKA 219 L +I+ DL N+L D++ + DF + + + + EII + + Sbjct: 147 LSIIHYDLNTGNMLYDKESESLFPIDF---RNIYAEYYAATKKDK----EIIDRRLQMRT 199 Query: 220 VDWWAL 225 D+++L Sbjct: 200 NDFYSL 205 >6G5I-z nrPDB Length = 568 Score = 32.9 bits (74), Expect = 0.21, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 32/68 (47%), Gaps = 2/68 (2%) Query: 119 MVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDQ 177 +VM ++ +M + L + + SE AR Q++ ++ L++ DL N ++ Sbjct: 275 LVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFN-MLYH 333 Query: 178 QGYIQVTD 185 G + + D Sbjct: 334 GGGVYIID 341 >4OTP-A nrPDB Length = 352 Score = 32.9 bits (74), Expect = 0.22, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 32/68 (47%), Gaps = 2/68 (2%) Query: 119 MVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDQ 177 +VM ++ +M + L + + SE AR Q++ ++ L++ DL N ++ Sbjct: 133 LVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFN-MLYH 191 Query: 178 QGYIQVTD 185 G + + D Sbjct: 192 GGGVYIID 199 >3LV4-A nrPDB Length = 456 Score = 31.8 bits (71), Expect = 0.52, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 15/43 (34%) Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP 142 P +V F N L+MV GG + + F P Sbjct: 142 KHPNVVDPHTFFDQNGKLWMVYGSYSGGIFILEMDKKTGFPLP 184 >2X8T-A nrPDB Length = 471 Score = 31.4 bits (70), Expect = 0.67, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 11/28 (39%) Query: 100 NFPFLVKLEYSFKDNSNLYMVMEYVPGG 127 P +V F + L+MV GG Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGG 192 >4GYG-A nrPDB Length = 397 Score = 31.0 bits (69), Expect = 0.76, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 25/78 (32%), Gaps = 16/78 (20%) Query: 119 MVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ 178 +VM + L S P A ++ L LI+ D N+LI ++ Sbjct: 188 IVM------SLVDALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREE 241 Query: 179 GYIQ----------VTDF 186 + + DF Sbjct: 242 KDAEDPSSITLTPIIIDF 259 >4IFQ-A nrPDB Length = 970 Score = 31.0 bits (69), Expect = 0.88, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 35/89 (39%), Gaps = 8/89 (8%) Query: 67 GNHFAMK-ILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVP 125 A + IL ++++ L + ILQ V+ F+V F +++ LY E + Sbjct: 86 DEIVACELILSGDTTANNGKVQYFLRRQYILQIVS--FIVN---CFHEDTELY--QELIK 138 Query: 126 GGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 G + S++ +F QI Sbjct: 139 NGALVSNILSAFKFIHTQLSEIKQQINKA 167 >3NPK-A nrPDB Length = 291 Score = 30.6 bits (68), Expect = 0.94, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 19/38 (50%) Query: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 L + + ++P A + L E++H+ LI+ DL Sbjct: 45 QLLLSVVQSNKPELLNQALDVALALEFIHTYSLIHDDL 82 >6FAI-l nrPDB Length = 425 Score = 30.6 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 35/167 (20%), Positives = 54/167 (32%), Gaps = 31/167 (18%) Query: 44 FERIKTLGTGSFGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 + T+G G + V K MKI + + K+ Q N+ Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 104 LVKL----EYSFK--------------DNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 145 L +L EY F DNS +VME + G M LR+ Sbjct: 154 LSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMR-RLRKHKNIP----- 207 Query: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLI------DQQGYIQVTDF 186 + ++ L + LI+ D N++I + V DF Sbjct: 208 KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >2QG7-A nrPDB Length = 458 Score = 29.8 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 36/105 (34%), Gaps = 18/105 (17%) Query: 66 TGNHFAMKILDKQKVV-------KLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLY 118 T +K + KQ K +I + EK+I + + K Y F N Sbjct: 121 TNILIKVKDMSKQAKYLIRLYGPKTDEIINREREKKISCILYNKNIAKKIYVFFTNGR-- 178 Query: 119 MVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 + E++ G + + +F + I + LH + L Sbjct: 179 -IEEFMDGYALSREDIKNPKFQKL--------IAKNLKLLHDIKL 214 >6EF6-A nrPDB Length = 354 Score = 29.8 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 12/28 (42%), Positives = 15/28 (53%), Gaps = 3/28 (10%) Query: 162 DLIYRDLKPENLLIDQQG---YIQVTDF 186 LI+ DL+ NLL+D I V DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >4ESA-B nrPDB Length = 146 Score = 29.5 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 20/51 (39%), Gaps = 5/51 (9%) Query: 53 GSFGRVMLVKHKETGNHFA---MKILD--KQKVVKLKQIEHTLNEKRILQA 98 GSFG + + A +K+L + V + I+ E IL + Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILHS 93 >4PKU-A nrPDB Length = 519 Score = 29.1 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 15/105 (14%), Positives = 42/105 (40%), Gaps = 7/105 (6%) Query: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL---LQVDLTKRFGNLKNGVNDIKNHKW 297 A + +EKI + S + + LL+ L ++ +L ++ Sbjct: 3 ALSRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQ 62 Query: 298 FATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINE 342 ++D+++ +++ F+ K + S ++ +E R+ ++ Sbjct: 63 IDSSDFLSTEEKE----FLKKLQIDIRDSLSEEEKELLNRIQVDS 103 >5Z96-A nrPDB Length = 755 Score = 28.7 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 31/193 (16%), Positives = 66/193 (34%), Gaps = 12/193 (6%) Query: 7 AKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKET 66 KK S ++ V L + P AH + +E IK L V Sbjct: 118 HKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLL-------VQKGVSVPR 170 Query: 67 GNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPG 126 + ++ + + H+ + I +A+ P L+ L + + E Sbjct: 171 PHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQEL 230 Query: 127 GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLI--YRDLKPENLLIDQQGYIQVT 184 ++ + + + +A ++ L++I YRD +N LI++Q + Sbjct: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRD---DNSLIEEQSGNDLA 287 Query: 185 DFGFAKRVKGRTW 197 A + + + + Sbjct: 288 RLKLAIKYRQKEF 300 >4WO8-A nrPDB Length = 716 Score = 28.7 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 18/32 (56%), Gaps = 2/32 (6%) Query: 188 FAKRVKGRTWTLCGTPEYLAPEIILSKGYNKA 219 AK ++G + C T +YL PEII K Y+ Sbjct: 372 LAKLLEGASIEKCYTRKYLTPEII--KKYDGK 401 >1PWU-A nrPDB Length = 776 Score = 28.7 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 14/103 (13%), Positives = 41/103 (39%), Gaps = 7/103 (6%) Query: 243 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL---LQVDLTKRFGNLKNGVNDIKNHKWFA 299 + +EKI + S + + LL+ L ++ +L ++ Sbjct: 266 SRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQID 325 Query: 300 TTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINE 342 ++D+++ +++ F+ K + S ++ +E R+ ++ Sbjct: 326 SSDFLSTEEKE----FLKKLQIDIRDSLSEEEKELLNRIQVDS 364 >3N98-A nrPDB Length = 562 Score = 28.3 bits (62), Expect = 5.6, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 40/105 (38%), Gaps = 24/105 (22%) Query: 231 EMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV- 289 E+ G F+ P + E++ F L+ LL + ++FG V Sbjct: 303 EVGLGEKEFYD--PDKAMERVEEHARHF--------VSLVERLL-REHEEKFGEKGIIVA 351 Query: 290 ---NDIKNHKWFATTDWIA-----IYQRKVEAP----FIPKFKGP 322 ++ H WF W+ +YQR VE P F+ ++ G Sbjct: 352 PYDTELFGHWWFEGVKWLGRVLELLYQRGVETPTLSRFLEEYSGE 396 >1IYN-A nrPDB Length = 295 Score = 27.9 bits (61), Expect = 6.3, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 23/44 (52%), Gaps = 1/44 (2%) Query: 178 QGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVD 221 + + ++++ G AK ++L G+P APE ++ Y+ D Sbjct: 253 EAHAKLSNLG-AKFGPAEGFSLEGSPAGAAPEKFVAAKYSTGKD 295 >3CRC-A nrPDB Length = 265 Score = 27.9 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 7/36 (19%), Positives = 18/36 (50%) Query: 55 FGRVMLVKHKETGNHFAMKILDKQKVVKLKQIEHTL 90 F V L +H T A++ +++ + +++E + Sbjct: 201 FATVNLARHLGTKAEIALQKANEKFERRFREVERIV 236 >6G1K-A nrPDB Length = 921 Score = 27.9 bits (61), Expect = 7.7, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 36/102 (35%), Gaps = 9/102 (8%) Query: 7 AKKGS-EQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKE 65 KK S E++ L K DF P AH + +E IK L V Sbjct: 118 HKKPSGEKQVPPILLDKQFSDFTPDI-TPIILAAHTNNYEIIKML-------VQKGVSVP 169 Query: 66 TGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 107 + ++ + + H+ + I +A+ P L+ L Sbjct: 170 QPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIAL 211 >1Z7A-A nrPDB Length = 308 Score = 27.5 bits (60), Expect = 7.8, Method: Composition-based stats. Identities = 14/57 (24%), Positives = 24/57 (42%), Gaps = 2/57 (3%) Query: 75 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFS 131 +D Q + + ++ EH L RIL + V + +VME GG ++ Sbjct: 131 IDYQYMDEAQEREHMLEAIRILTELTGQRPVGWYTGRTGPNTRRLVME--EGGFLYD 185 >6GL3-A nrPDB Length = 386 Score = 27.5 bits (60), Expect = 9.8, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 26/66 (39%), Gaps = 10/66 (15%) Query: 129 MFSHLRRIGRFSEP---HARFYAAQIVLT---FEYLHSLDLIYRDLKPENLLIDQQGYIQ 182 + L+ G ++ A+ Q YL + + N+L+D +G+I Sbjct: 219 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGHII 274 Query: 183 VTDFGF 188 DFGF Sbjct: 275 HIDFGF 280 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.153 0.463 Lambda K H 0.267 0.0469 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,212,110 Number of Sequences: 36641 Number of extensions: 753699 Number of successful extensions: 6860 Number of sequences better than 10.0: 533 Number of HSP's better than 10.0 without gapping: 932 Number of HSP's successfully gapped in prelim test: 83 Number of HSP's that attempted gapping in prelim test: 2794 Number of HSP's gapped (non-prelim): 1131 length of query: 351 length of database: 10,336,785 effective HSP length: 98 effective length of query: 253 effective length of database: 6,745,967 effective search space: 1706729651 effective search space used: 1706729651 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.5 bits)