BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P35557 (465 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4DCH-A nrPDB 961 0.0 3W0L-A nrPDB 780 0.0 5HFU-A nrPDB 528 e-150 4FOI-A nrPDB 520 e-148 1BG3-A nrPDB 512 e-145 3HM8-A nrPDB 493 e-140 1BDG-A nrPDB 366 e-101 3O1W-A nrPDB 275 3e-74 5ZQT-A nrPDB 252 3e-67 3B8A-X nrPDB 251 3e-67 4QS9-A nrPDB 244 4e-65 1IG8-A nrPDB 236 1e-62 2YHX-A nrPDB 52 8e-07 1HKG-A nrPDB 52 8e-07 3HYI-A nrPDB 32 0.40 3HYJ-A nrPDB 32 0.83 3F9V-A nrPDB 30 1.6 4FDG-B nrPDB 30 1.7 3N5M-A nrPDB 30 1.7 4A7F-C nrPDB 30 1.7 3E0V-A nrPDB 30 1.9 4R7Y-A nrPDB 30 1.9 2QM1-A nrPDB 30 2.5 >4DCH-A nrPDB Length = 473 Score = 961 bits (2483), Expect = 0.0, Method: Compositional matrix adjust. Identities = 465/465 (100%), Positives = 465/465 (100%) Query: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT 60 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT Sbjct: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT 60 Query: 61 YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE 120 YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE Sbjct: 61 YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE 120 Query: 121 MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN 180 MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN Sbjct: 121 MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN 180 Query: 181 VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN 240 VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN Sbjct: 181 VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN 240 Query: 241 VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE 300 VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE Sbjct: 241 VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE 300 Query: 301 LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS 360 LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS Sbjct: 301 LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS 360 Query: 361 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK 420 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK Sbjct: 361 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK 420 Query: 421 ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 465 ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ Sbjct: 421 ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 465 >3W0L-A nrPDB Length = 458 Score = 780 bits (2013), Expect = 0.0, Method: Compositional matrix adjust. Identities = 369/458 (80%), Positives = 417/458 (91%) Query: 8 MEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPE 67 ME + +V+QIL+EF LQEEDL +M RMQ EM+RGL LET+EEASVKMLPTYVRSTP+ Sbjct: 1 METFDQNEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPD 60 Query: 68 GSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYIS 127 GSEVGDFL+LDLGGTNFRVMLVKVGE EGQW V+TKH+MYSIP DAMTGTAEMLFDYI+ Sbjct: 61 GSEVGDFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIA 120 Query: 128 ECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRD 187 ECISD+LD+ MKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRD Sbjct: 121 ECISDYLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRD 180 Query: 188 AIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGD 247 AIKRRGDFEMDVVAMVNDTVATMISCYYEDH CEVG+IVGTGCNACYMEEM NVELVEG+ Sbjct: 181 AIKRRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGE 240 Query: 248 EGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLL 307 EGRMCVNTEWGAFGD+GEL++F LEYDR+VDE+S NPGQQLYEK+IGGKYMGELVRLVL+ Sbjct: 241 EGRMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLI 300 Query: 308 RLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIV 367 ++V+ENLLF GE+SE+L+TRGAFET+FVSQ+E+DT D KQ NIL TLG++ + DC V Sbjct: 301 KMVNENLLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAV 360 Query: 368 RRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASV 427 R ACESVSTRAA MCSAGLAG++NRMR+SR E+++RITVGVDGSVYKLHPSFK++FHA+V Sbjct: 361 RLACESVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATV 420 Query: 428 RRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 465 +LT CEITFI+SEEGSGRGAAL+SAVA K A M+G Sbjct: 421 LKLTSGCEITFIQSEEGSGRGAALISAVAYKMAVMIGH 458 >5HFU-A nrPDB Length = 923 Score = 528 bits (1359), Expect = e-150, Method: Compositional matrix adjust. Identities = 250/442 (56%), Positives = 334/442 (75%), Gaps = 2/442 (0%) Query: 17 EQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLS 76 ++ L QL + L +V RRM+ EM+RGL ETH A VKMLPTYV +TP+G+E GDFL+ Sbjct: 477 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLA 536 Query: 77 LDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK 136 LDLGGTNFRV+LV+V G+ G V+ +++Y+IP++ M GT + LFD+I +CI+DFL+ Sbjct: 537 LDLGGTNFRVLLVRVRNGKWG--GVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEY 594 Query: 137 HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFE 196 MK LPLGFTFSFP + +D+ ILL WTKGFKASG EG +VV LL++AI RR +F+ Sbjct: 595 MGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFD 654 Query: 197 MDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTE 256 +DVVA+VNDTV TM++C +ED CEVG+IVGTG NACYMEEM+NVELVEG+EGRMCVN E Sbjct: 655 LDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNME 714 Query: 257 WGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLF 316 WGAFGD+G LD+F E+D VDE S NPG+Q +EK+I G Y+GE+VR +L+ LLF Sbjct: 715 WGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLF 774 Query: 317 HGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVST 376 G SE+L+TRG FET+F+SQ+ESD Q+ IL LGL + D IV+ C V+ Sbjct: 775 RGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVAR 834 Query: 377 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEI 436 RAA +C AG+A V++R+RE+R D +++TVGVDG++YKLHP F + H +V+ L P C++ Sbjct: 835 RAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDV 894 Query: 437 TFIESEEGSGRGAALVSAVACK 458 +F++SE+GSG+GAAL++AVAC+ Sbjct: 895 SFLQSEDGSGKGAALITAVACR 916 Score = 528 bits (1359), Expect = e-150, Method: Compositional matrix adjust. Identities = 242/447 (54%), Positives = 340/447 (76%), Gaps = 2/447 (0%) Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 +KV+Q L +L +E L ++ +R +KEM++GL TH A+VKMLPT+VRSTP+G+E G+ Sbjct: 26 QKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGE 85 Query: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 FL+LDLGGTNFRV+ VKV + G V+ ++Q+Y+IPED M G+ LFD+I+EC+++F Sbjct: 86 FLALDLGGTNFRVLWVKVTD--NGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANF 143 Query: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 +DK Q+K KKLPLGFTFSFP +D+ L++WTKGFK+SG EG +VV L+R AI+RRG Sbjct: 144 MDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRG 203 Query: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253 DF++D+VA+VNDTV TM++C Y+DH CE+G+IVGTG NACYMEEM+++++VEGDEGRMC+ Sbjct: 204 DFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCI 263 Query: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 N EWGAFGD G L++ E+D+ +D S NPG+QL+EK+I G YMGELVRL+L+++ E Sbjct: 264 NMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEE 323 Query: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373 LLF G+ S +L G FET+ +S +E + ++ +L LGL P+ DC R C+ Sbjct: 324 LLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQI 383 Query: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433 VSTR+A +C+A LA V+ R++E++ E+ +R T+GVDGSVYK HP F +R H +VRRL P Sbjct: 384 VSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPG 443 Query: 434 CEITFIESEEGSGRGAALVSAVACKKA 460 C++ F+ SE+GSG+GAA+V+AVA + A Sbjct: 444 CDVRFLRSEDGSGKGAAMVTAVAYRLA 470 >4FOI-A nrPDB Length = 917 Score = 520 bits (1340), Expect = e-148, Method: Compositional matrix adjust. Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%) Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69 A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+ Sbjct: 464 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 523 Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129 E GDFL+LDLGGTNFRV+LVK+ G+ + +V+ +++Y+IP + M GT E LFD+I C Sbjct: 524 ENGDFLALDLGGTNFRVLLVKIRSGK--KRTVEMHNKIYAIPIEIMQGTGEELFDHIVSC 581 Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 ISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAI Sbjct: 582 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 641 Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249 KRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G Sbjct: 642 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 701 Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309 +MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+ Sbjct: 702 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 761 Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369 + LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ Sbjct: 762 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 821 Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429 C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+ Sbjct: 822 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 881 Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458 L+P C ++F+ SE+GSG+GAAL++AV + Sbjct: 882 LSPKCNVSFLLSEDGSGKGAALITAVGVR 910 Score = 486 bits (1251), Expect = e-138, Method: Compositional matrix adjust. Identities = 222/447 (49%), Positives = 322/447 (72%), Gaps = 2/447 (0%) Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 +K+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GD Sbjct: 20 KKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 79 Query: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 F++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF Sbjct: 80 FIALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDF 137 Query: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 ++K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RG Sbjct: 138 MEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRG 197 Query: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253 D++ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+ Sbjct: 198 DYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257 Query: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E Sbjct: 258 NTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEG 317 Query: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373 LLF G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C Sbjct: 318 LLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 377 Query: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433 VS R+A++ +A L ++NR+R+++ +R TVGV+GS+YK HP + RFH ++RRL P Sbjct: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTHPQYSRRFHKTLRRLVPD 437 Query: 434 CEITFIESEEGSGRGAALVSAVACKKA 460 ++ F+ SE GSG+GAA+V+AVA + A Sbjct: 438 SDVRFLLSESGSGKGAAMVTAVAYRLA 464 >1BG3-A nrPDB Length = 918 Score = 512 bits (1319), Expect = e-145, Method: Compositional matrix adjust. Identities = 236/449 (52%), Positives = 338/449 (75%), Gaps = 2/449 (0%) Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69 A + ++E+ LA F+L ++ L +V +R++ EM+ GLR ET+ +A+VKMLP++VRS P+G+ Sbjct: 464 AEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGT 523 Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129 E GDFL+LDLGGTNFRV+LVK+ G+ + +V+ +++YSIP + M GT + LFD+I C Sbjct: 524 EHGDFLALDLGGTNFRVLLVKIRSGK--KRTVEMHNKIYSIPLEIMQGTGDELFDHIVSC 581 Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 ISDFLD +K ++PLGFTFSFP ++D GIL++WTKGFKA+ EG++V LLRDA+ Sbjct: 582 ISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAV 641 Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249 KRR +F++DVVA+VNDTV TM++C YE+ CE+G+IVGTG NACYMEEM+NVE+VEG++G Sbjct: 642 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQG 701 Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309 +MC+N EWGAFGD+G LD+ ++D++VDE S N G+Q +EK+I G Y+GE+VR +L+ Sbjct: 702 QMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDF 761 Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369 + LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ Sbjct: 762 TKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 821 Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429 C VS RAA +C AG+A V+ ++RE+R D + +TVGVDG++YKLHP F H +V+ Sbjct: 822 VCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKE 881 Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458 L+P C ++F+ SE+GSG+GAAL++AV + Sbjct: 882 LSPKCTVSFLLSEDGSGKGAALITAVGVR 910 Score = 481 bits (1238), Expect = e-136, Method: Compositional matrix adjust. Identities = 224/447 (50%), Positives = 325/447 (72%), Gaps = 2/447 (0%) Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 +K+++ L +L +E L ++ R +KEM GL + + ASVKMLPT+VRS P+GSE GD Sbjct: 20 KKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGD 79 Query: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 F++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD++++C+ DF Sbjct: 80 FIALDLGGSSFRILRVQVNH--EKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDF 137 Query: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 ++K ++K KKLP+GFTFSFP R ID+ +L+ WTK FKASG EG +VV LL AIK+RG Sbjct: 138 MEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRG 197 Query: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253 D++ ++VA+VNDTV TM++C Y+D QCEVG+I+GTG NACYMEE+++++LVEGDEGRMC+ Sbjct: 198 DYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257 Query: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G YMGELVRL+L+++ E Sbjct: 258 NTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEG 317 Query: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373 LLF G + +L TRG F T VS +E D + IL+ LG+ PS DC V+ C Sbjct: 318 LLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTI 377 Query: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433 VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK+HP + RFH ++RRL P Sbjct: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD 437 Query: 434 CEITFIESEEGSGRGAALVSAVACKKA 460 ++ F+ SE G+G+GAA+V+AVA + A Sbjct: 438 SDVRFLLSESGTGKGAAMVTAVAYRLA 464 >3HM8-A nrPDB Length = 445 Score = 493 bits (1269), Expect = e-140, Method: Compositional matrix adjust. Identities = 235/445 (52%), Positives = 321/445 (72%), Gaps = 9/445 (2%) Query: 16 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 75 +E+ LA F+L + L V +M+K M +GLR E +S++MLPT+VR+TP+GSE GDFL Sbjct: 6 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERGDFL 62 Query: 76 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 135 +LDLGGTNFRV+LV+V G V+ ++YSIPE G+ + LFD+I +CI DF Sbjct: 63 ALDLGGTNFRVLLVRVTTG------VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQ 116 Query: 136 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 195 K + + LPLGFTFSFP R +D+GILLNWTKGFKAS EG +VV LLR+AI RR Sbjct: 117 KQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAV 176 Query: 196 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 255 E++VVA+VNDTV TM+SC YED +CE+G+IVGTG NACYMEE++NV V GD GRMC+N Sbjct: 177 ELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINM 236 Query: 256 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 315 EWGAFGD G L +D VD++S NPG+Q +EK+I G Y+GE+VR +LL L +L Sbjct: 237 EWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVL 296 Query: 316 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 375 F G+ ++L+TR F+T+F+S++ESD+ +Q+ IL LGL ++ D +V C++VS Sbjct: 297 FRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVS 356 Query: 376 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 435 RAA +C AG+A V+ ++RE+R + + ++VGVDG++YKLHP F A+VR L P C Sbjct: 357 QRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCV 416 Query: 436 ITFIESEEGSGRGAALVSAVACKKA 460 +TF++SE+GSG+GAALV+AVAC+ A Sbjct: 417 VTFLQSEDGSGKGAALVTAVACRLA 441 >1BDG-A nrPDB Length = 451 Score = 366 bits (939), Expect = e-101, Method: Compositional matrix adjust. Identities = 199/451 (44%), Positives = 289/451 (64%), Gaps = 25/451 (5%) Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 EKV +IL F L D +++ RM + M GL+ T+E++S+KM P+YV TP G+E G+ Sbjct: 10 EKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGN 69 Query: 74 FLSLDLGGTNFRVMLVKV-GEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISD 132 FL+LDLGGTN+RV+ V + G+G+ S + + + Y IP + M+G+ LF YI+E ++D Sbjct: 70 FLALDLGGTNYRVLSVTLEGKGK----SPRIQERTYCIPAEKMSGSGTELFKYIAETLAD 125 Query: 133 FLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR 192 FL+ + MK KK LGFTFSFP + + L+ WTKGF A G EG+NV LL+ + +R Sbjct: 126 FLENNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKR 185 Query: 193 GDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG-DEGRM 251 + + VA+VNDTV T+ SC ED +C VG+IVGTG N Y+E+ VEL++G E + Sbjct: 186 -ELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEV 244 Query: 252 CVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVD 311 +NTEWGAFG+ GELD + ++D+ +D S +PG+QLYEK++ G Y+GELVR +++ LV+ Sbjct: 245 VINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVE 304 Query: 312 ENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNI-------LSTLGLRPSTTDC 364 + +LF G+ E+L+ R + TR+++ VE D +YN L + P D Sbjct: 305 QKILFRGDLPERLKVRNSLLTRYLTDVERDPA--HLLYNTHYMLTDDLHVPVVEP--IDN 360 Query: 365 DIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFH 424 IVR ACE V RAA++ AG+A ++ R+ +RSE +TVGVDGS+YK HP F ER Sbjct: 361 RIVRYACEMVVKRAAYLAGAGIACILRRI--NRSE----VTVGVDGSLYKFHPKFCERMT 414 Query: 425 ASVRRLTP-SCEITFIESEEGSGRGAALVSA 454 V +L P + SE+GSG+GAA ++A Sbjct: 415 DMVDKLKPKNTRFCLRLSEDGSGKGAAAIAA 445 >3O1W-A nrPDB Length = 485 Score = 275 bits (703), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 150/472 (31%), Positives = 265/472 (56%), Gaps = 33/472 (6%) Query: 6 ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 65 A + A E++ + F + E ++ +++ E+D+GL + + ++ M+P +V Sbjct: 17 ADVPANLMEQIHGLETLFTVSSEKMRSIVKHFISELDKGL---SKKGGNIPMIPGWVVEY 73 Query: 66 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDY 125 P G E GDFL+LDLGGTN RV+LVK+G G T Y +P+ TGT+E L+ + Sbjct: 74 PTGKETGDFLALDLGGTNLRVVLVKLG----GNHDFDTTQNKYRLPDHLRTGTSEQLWSF 129 Query: 126 ISECISDFLDKHQMK--HKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVG 183 I++C+ +F+D+ + LPLGFTFS+P + I+ G+L WTKGF G EG++VV Sbjct: 130 IAKCLKEFVDEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVP 189 Query: 184 LLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVEL 243 +L++ I++ + ++VVA++NDT T+++ Y D Q ++G+I+GTG N Y + + +E Sbjct: 190 MLQEQIEKL-NIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEK 248 Query: 244 VEG-------DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGK 296 +EG + M +N E+G+F D+ L +YD ++DE S PGQQ +EK+ G Sbjct: 249 LEGLLPEDIGPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGY 307 Query: 297 YMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNIL--ST 354 Y+GE++RLVLL L D +F + +L+ +T + S++E D + + + L + Sbjct: 308 YLGEIMRLVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTN 367 Query: 355 LGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYK 414 L + + + ++R+ E V TRAA + G++ + ++ + + DGSV+ Sbjct: 368 LNIETTVVERKLIRKLAELVGTRAARLTVCGVSAICDKRGYKTAH------IAADGSVFN 421 Query: 415 LHPSFKERFHASVRRL-------TPSCEITFIESEEGSGRGAALVSAVACKK 459 +P +KE+ +++ + I + +E+GSG GAA+++ + K+ Sbjct: 422 RYPGYKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQKR 473 >5ZQT-A nrPDB Length = 473 Score = 252 bits (643), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 168/476 (35%), Positives = 253/476 (53%), Gaps = 29/476 (6%) Query: 5 RARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRS 64 R M AA E+VEQ F L+ + M +EM+RGLR + H A +KML +YV + Sbjct: 8 RIPMAAAVIEEVEQ---RFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDN 62 Query: 65 TPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFD 124 P G E G F +LDLGGTNFRV+ V++G G E + V +++ +IP M GT+ LFD Sbjct: 63 LPTGDEHGLFYALDLGGTNFRVIRVQLG-GREKR-VVSQQYEEVAIPPHLMVGTSMELFD 120 Query: 125 YISECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGN 179 +I+ + F+ D H + ++ LGFTFSFPV I G L+ WTKGF +G G Sbjct: 121 FIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGE 180 Query: 180 NVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQ 239 +VV L A++R+G +M V A+VNDTV T+ Y D+ +I+GTG NA Y+E Sbjct: 181 DVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHAN 239 Query: 240 NVELVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGK 296 + G G M +N EWG F S L +YD +D S NPG+Q+YEK+I G Sbjct: 240 AIPKWTGLLPRSGNMVINMEWGNF-KSERLPRS--DYDNALDFESLNPGEQIYEKMISGM 296 Query: 297 YMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTG-DRKQI-YNILST 354 Y+GE+VR +LL+L + LF +L R T +S + DT D K + + Sbjct: 297 YLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDI 356 Query: 355 LGLRPSTTDCD-IVRRACESVSTRAAHMCSAGLAGVINRMRESR----SEDVMRITVGVD 409 LG+ ++ + I C+ V+ R A + +AG+ G++ ++ R R + +D Sbjct: 357 LGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALD 416 Query: 410 GSVYKLHPSFKERFHASVRRLT---PSCEITFIESEEGSGRGAALVSAVACKKACM 462 G +Y+ + F+ A++ L + + + +GSG GAAL++A + A + Sbjct: 417 GGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 472 >3B8A-X nrPDB Length = 485 Score = 251 bits (642), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 156/466 (33%), Positives = 261/466 (56%), Gaps = 37/466 (7%) Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 +++ Q+ F + E L+KV++ E+++GL T + ++ M+P +V P G E G+ Sbjct: 25 DEIHQLEDMFTVDSETLRKVVKHFIDELNKGL---TKKGGNIPMIPGWVMEFPTGKESGN 81 Query: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDA-MTGTAEMLFDYISECISD 132 +L++DLGGTN RV+LVK+ G + T Y +P D T E L+ +I++ + D Sbjct: 82 YLAIDLGGTNLRVVLVKL----SGNHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKD 137 Query: 133 FLDKHQMKHKK--LPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIK 190 F+ + ++ + K LPLGFTFS+P I++GIL WTKGF EG++VV LL++ I Sbjct: 138 FMVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEIS 197 Query: 191 RRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG---- 246 +R + +++VA++NDTV T+I+ YY D + ++G+I GTG N + + + ++E +EG Sbjct: 198 KR-ELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLAD 256 Query: 247 ---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVR 303 M +N E+G+F D+ L +YD VDE S PGQQ +EK+ G Y+GEL+R Sbjct: 257 DIPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLR 315 Query: 304 LVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT----GDRKQIYNILSTLGLRP 359 LVLL L ++ L+ + +L+ +T + +++E D D I+ G++ Sbjct: 316 LVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQ--KDFGVKT 373 Query: 360 STTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSF 419 + + ++RR CE + TRAA + G+A + + + DGSVY +P F Sbjct: 374 TLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGH------IAADGSVYNKYPGF 427 Query: 420 KERFHASVRRL------TPSCEITFIESEEGSGRGAALVSAVACKK 459 KE +R + IT + +E+GSG GAA+++A++ K+ Sbjct: 428 KEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEKR 473 >4QS9-A nrPDB Length = 474 Score = 244 bits (624), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 162/465 (34%), Positives = 255/465 (54%), Gaps = 35/465 (7%) Query: 15 KVEQILAEFQLQEED-------LKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPE 67 K ++LA + EED L++V M EM GL + + +KML +YV + P Sbjct: 11 KWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGL--ASDGGSKLKMLISYVDNLPS 68 Query: 68 GSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYIS 127 G E G F +LDLGGTNFRVM V +G +E VK + + SIP MTG ++ LF++I+ Sbjct: 69 GDEKGLFYALDLGGTNFRVMRVLLGGKQE--RVVKQEFEEVSIPPHLMTGGSDELFNFIA 126 Query: 128 ECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVV 182 E ++ F+ D H + ++ LGFTF+FPV+ + G L+ WTKGF A G +VV Sbjct: 127 EALAKFVATECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVV 186 Query: 183 GLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVE 242 G L A++R G +M + A+VNDTV T+ Y + +I+GTG NA Y+E + Sbjct: 187 GALNKALERVG-LDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIP 245 Query: 243 LVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMG 299 G G M +N EWG F S L L E+D +D S NPG+Q+ EK+I G Y+G Sbjct: 246 KWHGLLPKSGEMVINMEWGNF-RSSHLP--LTEFDHTLDFESLNPGEQILEKIISGMYLG 302 Query: 300 ELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTG-DRKQIYNILSTLGLR 358 E++R VLL++ ++ F +LR T +S + +DT D K + + + + Sbjct: 303 EILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV 362 Query: 359 PSTTDC--DIVRRACESVSTRAAHMCSAGLAGVINRM--RESRSEDVMRITVGVDGSVYK 414 P+T+ +V C ++TR A + +AG+ G++ ++ ++ E+V + + +DG +++ Sbjct: 363 PTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFE 422 Query: 415 LHPSFKERFHASVRRL-----TPSCEITFIESEEGSGRGAALVSA 454 + F E +S++ L + S E+T S +GSG GAAL++A Sbjct: 423 HYTQFSECMESSLKELLGDEASGSVEVT--HSNDGSGIGAALLAA 465 >1IG8-A nrPDB Length = 486 Score = 236 bits (603), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 133/430 (30%), Positives = 233/430 (54%), Gaps = 29/430 (6%) Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 +++E F + E L+ V + E+++GL + + ++ M+P +V P G E GD Sbjct: 25 QQIENFEKIFTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDFPTGKESGD 81 Query: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAM--TGTAEMLFDYISECIS 131 FL++DLGGTN RV+LVK+G G + T Y +P DAM T + L+++I++ + Sbjct: 82 FLAIDLGGTNLRVVLVKLG----GDRTFDTTQSKYRLP-DAMRTTQNPDELWEFIADSLK 136 Query: 132 DFLDKH--QMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 F+D+ Q + +PLGFTFSFP I++GIL WTKGF E ++VV +L+ I Sbjct: 137 AFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQI 196 Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG--- 246 +R + ++VVA++NDT T+++ YY D + ++G+I GTG N Y + ++E ++G Sbjct: 197 TKR-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLS 255 Query: 247 ----DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELV 302 M +N E+G+F D+ + +YD +DE S PGQQ +EK+ G Y+GE++ Sbjct: 256 DDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEIL 314 Query: 303 RLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNIL--STLGLRPS 360 RL L+ + + +F + + +T + +++E D + + + L + G+ + Sbjct: 315 RLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTT 374 Query: 361 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK 420 + ++RR E + RAA + G+A + + + DGSVY +P FK Sbjct: 375 VQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH------IAADGSVYNRYPGFK 428 Query: 421 ERFHASVRRL 430 E+ +++ + Sbjct: 429 EKAANALKDI 438 >2YHX-A nrPDB Length = 457 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 44/184 (23%), Positives = 75/184 (40%), Gaps = 14/184 (7%) Query: 55 VKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQW----SVKTKHQMYSI 110 + M+P +V G++ G FL++ +GG + V+L+ + +E S+ +I Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTTAI 103 Query: 111 PEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKG 170 P D A + + +PLGFTF E + KG + Sbjct: 104 PSDLWGNXAX-------SNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 171 FKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGC 230 F S A ++ + +A GD VA + D+ + Y D ++G+I G+G Sbjct: 157 F--SLAXLXKLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 231 NACY 234 NA Y Sbjct: 214 NAAY 217 >1HKG-A nrPDB Length = 457 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 45/184 (24%), Positives = 75/184 (40%), Gaps = 14/184 (7%) Query: 55 VKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQW----SVKTKHQMYSI 110 + M+P +V GS+ G FL++ +GG + V+L+ + +E S+ +I Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103 Query: 111 PEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKG 170 P D A + + +PLGFTF E + KG + Sbjct: 104 PSDLWGNXAX-------SNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 171 FKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGC 230 F S A ++ + +A GD VA + D+ + Y D ++G+I G+G Sbjct: 157 F--SLAXLXKLISAMXNAXFPAGD-XXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 231 NACY 234 NA Y Sbjct: 214 NAAY 217 >3HYI-A nrPDB Length = 295 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 27/149 (18%), Positives = 62/149 (41%), Gaps = 14/149 (9%) Query: 97 GQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL--DKHQMKHK--KLPLGFTFSF 152 G VK++H ++S+ A + L Y+S+ +S+ + H +K + K+ ++ SF Sbjct: 40 GDLDVKSRHIVFSLHSFAASRRLLNLMKYLSKPVSEIIVEKSHNIKKRYIKITAEYSESF 99 Query: 153 PVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMIS 212 V D + +++ +G SG N R + +++ +T+A Sbjct: 100 MVIEPFFDVALFVSFLRGLFLSGGSMTNP----------RYHYHLEINLFEEETLALTRK 149 Query: 213 CYYEDHQCEVGMIVGTGCNACYMEEMQNV 241 + G+I Y++ ++++ Sbjct: 150 SLKDFFNINAGIIELRNTRKLYIKSIKDI 178 >3HYJ-A nrPDB Length = 198 Score = 31.6 bits (70), Expect = 0.83, Method: Compositional matrix adjust. Identities = 27/149 (18%), Positives = 62/149 (41%), Gaps = 14/149 (9%) Query: 97 GQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL--DKHQMKHK--KLPLGFTFSF 152 G VK++H ++S+ A + L Y+S+ +S+ + H +K + K+ ++ SF Sbjct: 40 GDLDVKSRHIVFSLHSFAASRRLLNLMKYLSKPVSEIIVEKSHNIKKRYIKITAEYSESF 99 Query: 153 PVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMIS 212 V D + +++ +G SG N R + +++ +T+A Sbjct: 100 MVIEPFFDVALFVSFLRGLFLSGGSMTN----------PRYHYHLEINLFEEETLALTRK 149 Query: 213 CYYEDHQCEVGMIVGTGCNACYMEEMQNV 241 + G+I Y++ ++++ Sbjct: 150 SLKDFFNINAGIIELRNTRKLYIKSIKDI 178 >3F9V-A nrPDB Length = 595 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 39/87 (44%), Gaps = 3/87 (3%) Query: 379 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITF 438 H+ G+ VI +R+ RS D+ ++ + +DG + K+ P + + A+ + + P C F Sbjct: 90 VHVRIVGIPRVIE-LRKIRSTDIGKL-ITIDGILVKVTPVKERIYKATYKHIHPDCMQEF 147 Query: 439 IESEEGSGRGAALVSAVACKKACMLGQ 465 E E L C K GQ Sbjct: 148 -EWPEDEEMPEVLEMPTICPKCGKPGQ 173 >4FDG-B nrPDB Length = 692 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 39/87 (44%), Gaps = 3/87 (3%) Query: 379 AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITF 438 H+ G+ VI +R+ RS D+ ++ + +DG + K+ P + + A+ + + P C F Sbjct: 102 VHVRIVGIPRVIE-LRKIRSTDIGKL-ITIDGILVKVTPVKERIYKATYKHIHPDCMQEF 159 Query: 439 IESEEGSGRGAALVSAVACKKACMLGQ 465 E E L C K GQ Sbjct: 160 -EWPEDEEMPEVLEMPTICPKCGKPGQ 185 >3N5M-A nrPDB Length = 452 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 34/158 (21%), Positives = 57/158 (36%), Gaps = 26/158 (16%) Query: 226 VGTGCNACYMEEMQNVELVEGDEGRMCVNTEWG-------AFGDSGELDEFLLEYDRLVD 278 VG C++E++Q ++G G CVN+ +G A+ L F + Sbjct: 34 VGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSYFPM------- 86 Query: 279 ESSANPGQQLYEKL---IGGKYM------GELVRLVLLRLVDENLLFHGEASE---QLRT 326 S P +L EKL +GG+Y+ G ++ + GE R Sbjct: 87 SQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRY 146 Query: 327 RGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDC 364 RG + + R+ Y ++ L + DC Sbjct: 147 RGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPDC 184 >4A7F-C nrPDB Length = 697 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 28/107 (26%), Positives = 50/107 (46%), Gaps = 14/107 (13%) Query: 256 EWGAFGDS--GELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 ++ A G G++ +LLE R+V + ++ +++ G +L L Sbjct: 167 QFNAVGSPIGGKITNYLLEKSRVVGRTQGERSFHIFYQMLKGLSQSKLDEL--------G 218 Query: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS 360 L + A E L+ G F+ VS ++ D+G+ K I + TLGL+ S Sbjct: 219 LTPNAPAYEYLKKSGCFD---VSTID-DSGEFKIIVKAMETLGLKES 261 >3E0V-A nrPDB Length = 539 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 25/57 (43%), Gaps = 6/57 (10%) Query: 237 EMQNVELVEGD----EGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLY 289 E++ + V GD G C T AF D G D+F ++Y L PG +Y Sbjct: 129 EIRTGQFVGGDAVMERGATCYVTTDPAFADKGTKDKFYIDYQNL--SKVVRPGNYIY 183 >4R7Y-A nrPDB Length = 613 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 23/86 (26%), Positives = 39/86 (45%), Gaps = 3/86 (3%) Query: 380 HMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFI 439 H+ G+ VI +R+ RS D+ ++ + +DG + K+ P + + A+ + + P C F Sbjct: 98 HVRIVGIPRVIE-LRKIRSTDIGKL-ITIDGILVKVTPVKERIYKATYKHIHPDCMQEF- 154 Query: 440 ESEEGSGRGAALVSAVACKKACMLGQ 465 E E L C K GQ Sbjct: 155 EWPEDEEMPEVLEMPTICPKCGKPGQ 180 >2QM1-A nrPDB Length = 326 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 45/100 (45%), Gaps = 17/100 (17%) Query: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 + +DLGGT + ++ + +WS++T +I ED + + I E I Sbjct: 8 IIGIDLGGTTIKFAILTTDGVVQQKWSIET-----NILED-----GKHIVPSIIESIRHR 57 Query: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGIL-----LNWT 168 +D + MK + +G P DI+KG + LNWT Sbjct: 58 IDLYNMKKEDF-VGIGMGTP-GSVDIEKGTVVGAYNLNWT 95 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4DCH-A nrPDB 680 0.0 4FOI-A nrPDB 674 0.0 1BG3-A nrPDB 672 0.0 5HFU-A nrPDB 663 0.0 3W0L-A nrPDB 655 0.0 3HM8-A nrPDB 605 e-173 3O1W-A nrPDB 571 e-163 3B8A-X nrPDB 543 e-155 1IG8-A nrPDB 542 e-154 1BDG-A nrPDB 538 e-153 5ZQT-A nrPDB 522 e-148 4QS9-A nrPDB 495 e-140 2YHX-A nrPDB 203 1e-52 1HKG-A nrPDB 195 4e-50 Sequences not found previously or not previously below threshold: 2C7B-A nrPDB 29 3.8 4WGK-A nrPDB 29 4.7 1R6M-A nrPDB 29 5.5 1WZC-A nrPDB 28 6.1 CONVERGED! >4DCH-A nrPDB Length = 473 Score = 680 bits (1754), Expect = 0.0, Method: Composition-based stats. Identities = 465/465 (100%), Positives = 465/465 (100%) Query: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT 60 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT Sbjct: 1 MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT 60 Query: 61 YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE 120 YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE Sbjct: 61 YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE 120 Query: 121 MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN 180 MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN Sbjct: 121 MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN 180 Query: 181 VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN 240 VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN Sbjct: 181 VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN 240 Query: 241 VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE 300 VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE Sbjct: 241 VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE 300 Query: 301 LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS 360 LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS Sbjct: 301 LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS 360 Query: 361 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK 420 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK Sbjct: 361 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK 420 Query: 421 ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 465 ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ Sbjct: 421 ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 465 >4FOI-A nrPDB Length = 917 Score = 674 bits (1739), Expect = 0.0, Method: Composition-based stats. Identities = 244/450 (54%), Positives = 334/450 (74%), Gaps = 2/450 (0%) Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69 A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+ Sbjct: 464 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 523 Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129 E GDFL+LDLGGTNFRV+LVK+ G+ + +V+ +++Y+IP + M GT E LFD+I C Sbjct: 524 ENGDFLALDLGGTNFRVLLVKIRSGK--KRTVEMHNKIYAIPIEIMQGTGEELFDHIVSC 581 Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 ISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAI Sbjct: 582 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 641 Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249 KRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G Sbjct: 642 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 701 Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309 +MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+ Sbjct: 702 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 761 Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369 + LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ Sbjct: 762 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 821 Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429 C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+ Sbjct: 822 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 881 Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACKK 459 L+P C ++F+ SE+GSG+GAAL++AV + Sbjct: 882 LSPKCNVSFLLSEDGSGKGAALITAVGVRL 911 Score = 520 bits (1340), Expect = e-148, Method: Composition-based stats. Identities = 222/450 (49%), Positives = 323/450 (71%), Gaps = 2/450 (0%) Query: 11 AKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE 70 + +K+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE Sbjct: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76 Query: 71 VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECI 130 GDF++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ Sbjct: 77 KGDFIALDLGGSSFRILRVQV--NHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECL 134 Query: 131 SDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIK 190 DF++K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK Sbjct: 135 GDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIK 194 Query: 191 RRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR 250 +RGD++ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGR Sbjct: 195 KRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGR 254 Query: 251 MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLV 310 MC+NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ Sbjct: 255 MCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMA 314 Query: 311 DENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRA 370 E LLF G + +L TRG F T VS +E + IL+ LG+ PS DC V+ Sbjct: 315 KEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHV 374 Query: 371 CESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL 430 C VS R+A++ +A L ++NR+R+++ +R TVGV+GS+YK HP + RFH ++RRL Sbjct: 375 CTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTHPQYSRRFHKTLRRL 434 Query: 431 TPSCEITFIESEEGSGRGAALVSAVACKKA 460 P ++ F+ SE GSG+GAA+V+AVA + A Sbjct: 435 VPDSDVRFLLSESGSGKGAAMVTAVAYRLA 464 >1BG3-A nrPDB Length = 918 Score = 672 bits (1735), Expect = 0.0, Method: Composition-based stats. Identities = 236/450 (52%), Positives = 338/450 (75%), Gaps = 2/450 (0%) Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69 A + ++E+ LA F+L ++ L +V +R++ EM+ GLR ET+ +A+VKMLP++VRS P+G+ Sbjct: 464 AEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGT 523 Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129 E GDFL+LDLGGTNFRV+LVK+ G+ + +V+ +++YSIP + M GT + LFD+I C Sbjct: 524 EHGDFLALDLGGTNFRVLLVKIRSGK--KRTVEMHNKIYSIPLEIMQGTGDELFDHIVSC 581 Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 ISDFLD +K ++PLGFTFSFP ++D GIL++WTKGFKA+ EG++V LLRDA+ Sbjct: 582 ISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAV 641 Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249 KRR +F++DVVA+VNDTV TM++C YE+ CE+G+IVGTG NACYMEEM+NVE+VEG++G Sbjct: 642 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQG 701 Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309 +MC+N EWGAFGD+G LD+ ++D++VDE S N G+Q +EK+I G Y+GE+VR +L+ Sbjct: 702 QMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDF 761 Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369 + LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ Sbjct: 762 TKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 821 Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429 C VS RAA +C AG+A V+ ++RE+R D + +TVGVDG++YKLHP F H +V+ Sbjct: 822 VCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKE 881 Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACKK 459 L+P C ++F+ SE+GSG+GAAL++AV + Sbjct: 882 LSPKCTVSFLLSEDGSGKGAALITAVGVRL 911 Score = 513 bits (1321), Expect = e-146, Method: Composition-based stats. Identities = 224/450 (49%), Positives = 326/450 (72%), Gaps = 2/450 (0%) Query: 11 AKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSE 70 + +K+++ L +L +E L ++ R +KEM GL + + ASVKMLPT+VRS P+GSE Sbjct: 17 DQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSE 76 Query: 71 VGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECI 130 GDF++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD++++C+ Sbjct: 77 KGDFIALDLGGSSFRILRVQV--NHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCL 134 Query: 131 SDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIK 190 DF++K ++K KKLP+GFTFSFP R ID+ +L+ WTK FKASG EG +VV LL AIK Sbjct: 135 GDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIK 194 Query: 191 RRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR 250 +RGD++ ++VA+VNDTV TM++C Y+D QCEVG+I+GTG NACYMEE+++++LVEGDEGR Sbjct: 195 KRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGR 254 Query: 251 MCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLV 310 MC+NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G YMGELVRL+L+++ Sbjct: 255 MCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMA 314 Query: 311 DENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRA 370 E LLF G + +L TRG F T VS +E D + IL+ LG+ PS DC V+ Sbjct: 315 KEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHI 374 Query: 371 CESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL 430 C VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK+HP + RFH ++RRL Sbjct: 375 CTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRL 434 Query: 431 TPSCEITFIESEEGSGRGAALVSAVACKKA 460 P ++ F+ SE G+G+GAA+V+AVA + A Sbjct: 435 VPDSDVRFLLSESGTGKGAAMVTAVAYRLA 464 >5HFU-A nrPDB Length = 923 Score = 663 bits (1711), Expect = 0.0, Method: Composition-based stats. Identities = 251/449 (55%), Positives = 336/449 (74%), Gaps = 2/449 (0%) Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69 A + ++ L QL + L +V RRM+ EM+RGL ETH A VKMLPTYV +TP+G+ Sbjct: 470 ADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGT 529 Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129 E GDFL+LDLGGTNFRV+LV+V G+ G V+ +++Y+IP++ M GT + LFD+I +C Sbjct: 530 EKGDFLALDLGGTNFRVLLVRVRNGKWG--GVEMHNKIYAIPQEVMHGTGDELFDHIVQC 587 Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 I+DFL+ MK LPLGFTFSFP + +D+ ILL WTKGFKASG EG +VV LL++AI Sbjct: 588 IADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAI 647 Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249 RR +F++DVVA+VNDTV TM++C +ED CEVG+IVGTG NACYMEEM+NVELVEG+EG Sbjct: 648 HRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEG 707 Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309 RMCVN EWGAFGD+G LD+F E+D VDE S NPG+Q +EK+I G Y+GE+VR +L+ Sbjct: 708 RMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDF 767 Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369 LLF G SE+L+TRG FET+F+SQ+ESD Q+ IL LGL + D IV+ Sbjct: 768 TKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKE 827 Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429 C V+ RAA +C AG+A V++R+RE+R D +++TVGVDG++YKLHP F + H +V+ Sbjct: 828 VCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKD 887 Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458 L P C+++F++SE+GSG+GAAL++AVAC+ Sbjct: 888 LAPKCDVSFLQSEDGSGKGAALITAVACR 916 Score = 562 bits (1449), Expect = e-161, Method: Composition-based stats. Identities = 242/451 (53%), Positives = 342/451 (75%), Gaps = 2/451 (0%) Query: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69 + + +KV+Q L +L +E L ++ +R +KEM++GL TH A+VKMLPT+VRSTP+G+ Sbjct: 22 SDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGT 81 Query: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129 E G+FL+LDLGGTNFRV+ VKV + G V+ ++Q+Y+IPED M G+ LFD+I+EC Sbjct: 82 EHGEFLALDLGGTNFRVLWVKVTD--NGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAEC 139 Query: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 +++F+DK Q+K KKLPLGFTFSFP +D+ L++WTKGFK+SG EG +VV L+R AI Sbjct: 140 LANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAI 199 Query: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249 +RRGDF++D+VA+VNDTV TM++C Y+DH CE+G+IVGTG NACYMEEM+++++VEGDEG Sbjct: 200 QRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEG 259 Query: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309 RMC+N EWGAFGD G L++ E+D+ +D S NPG+QL+EK+I G YMGELVRL+L+++ Sbjct: 260 RMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKM 319 Query: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369 E LLF G+ S +L G FET+ +S +E + ++ +L LGL P+ DC R Sbjct: 320 AKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHR 379 Query: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429 C+ VSTR+A +C+A LA V+ R++E++ E+ +R T+GVDGSVYK HP F +R H +VRR Sbjct: 380 ICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRR 439 Query: 430 LTPSCEITFIESEEGSGRGAALVSAVACKKA 460 L P C++ F+ SE+GSG+GAA+V+AVA + A Sbjct: 440 LVPGCDVRFLRSEDGSGKGAAMVTAVAYRLA 470 >3W0L-A nrPDB Length = 458 Score = 655 bits (1691), Expect = 0.0, Method: Composition-based stats. Identities = 369/458 (80%), Positives = 417/458 (91%) Query: 8 MEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPE 67 ME + +V+QIL+EF LQEEDL +M RMQ EM+RGL LET+EEASVKMLPTYVRSTP+ Sbjct: 1 METFDQNEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPD 60 Query: 68 GSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYIS 127 GSEVGDFL+LDLGGTNFRVMLVKVGE EGQW V+TKH+MYSIP DAMTGTAEMLFDYI+ Sbjct: 61 GSEVGDFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIA 120 Query: 128 ECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRD 187 ECISD+LD+ MKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRD Sbjct: 121 ECISDYLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRD 180 Query: 188 AIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGD 247 AIKRRGDFEMDVVAMVNDTVATMISCYYEDH CEVG+IVGTGCNACYMEEM NVELVEG+ Sbjct: 181 AIKRRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGE 240 Query: 248 EGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLL 307 EGRMCVNTEWGAFGD+GEL++F LEYDR+VDE+S NPGQQLYEK+IGGKYMGELVRLVL+ Sbjct: 241 EGRMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLI 300 Query: 308 RLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIV 367 ++V+ENLLF GE+SE+L+TRGAFET+FVSQ+E+DT D KQ NIL TLG++ + DC V Sbjct: 301 KMVNENLLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAV 360 Query: 368 RRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASV 427 R ACESVSTRAA MCSAGLAG++NRMR+SR E+++RITVGVDGSVYKLHPSFK++FHA+V Sbjct: 361 RLACESVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATV 420 Query: 428 RRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 465 +LT CEITFI+SEEGSGRGAAL+SAVA K A M+G Sbjct: 421 LKLTSGCEITFIQSEEGSGRGAALISAVAYKMAVMIGH 458 >3HM8-A nrPDB Length = 445 Score = 605 bits (1559), Expect = e-173, Method: Composition-based stats. Identities = 235/447 (52%), Positives = 322/447 (72%), Gaps = 9/447 (2%) Query: 16 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 75 +E+ LA F+L + L V +M+K M +GLR E +S++MLPT+VR+TP+GSE GDFL Sbjct: 6 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERGDFL 62 Query: 76 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 135 +LDLGGTNFRV+LV+V G V+ ++YSIPE G+ + LFD+I +CI DF Sbjct: 63 ALDLGGTNFRVLLVRVTTG------VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQ 116 Query: 136 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 195 K + + LPLGFTFSFP R +D+GILLNWTKGFKAS EG +VV LLR+AI RR Sbjct: 117 KQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAV 176 Query: 196 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 255 E++VVA+VNDTV TM+SC YED +CE+G+IVGTG NACYMEE++NV V GD GRMC+N Sbjct: 177 ELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINM 236 Query: 256 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 315 EWGAFGD G L +D VD++S NPG+Q +EK+I G Y+GE+VR +LL L +L Sbjct: 237 EWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVL 296 Query: 316 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 375 F G+ ++L+TR F+T+F+S++ESD+ +Q+ IL LGL ++ D +V C++VS Sbjct: 297 FRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVS 356 Query: 376 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 435 RAA +C AG+A V+ ++RE+R + + ++VGVDG++YKLHP F A+VR L P C Sbjct: 357 QRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCV 416 Query: 436 ITFIESEEGSGRGAALVSAVACKKACM 462 +TF++SE+GSG+GAALV+AVAC+ A + Sbjct: 417 VTFLQSEDGSGKGAALVTAVACRLAQL 443 >3O1W-A nrPDB Length = 485 Score = 571 bits (1472), Expect = e-163, Method: Composition-based stats. Identities = 150/472 (31%), Positives = 265/472 (56%), Gaps = 33/472 (6%) Query: 6 ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 65 A + A E++ + F + E ++ +++ E+D+GL + + ++ M+P +V Sbjct: 17 ADVPANLMEQIHGLETLFTVSSEKMRSIVKHFISELDKGL---SKKGGNIPMIPGWVVEY 73 Query: 66 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDY 125 P G E GDFL+LDLGGTN RV+LVK+G G T Y +P+ TGT+E L+ + Sbjct: 74 PTGKETGDFLALDLGGTNLRVVLVKLG----GNHDFDTTQNKYRLPDHLRTGTSEQLWSF 129 Query: 126 ISECISDFLDKHQMKH--KKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVG 183 I++C+ +F+D+ + LPLGFTFS+P + I+ G+L WTKGF G EG++VV Sbjct: 130 IAKCLKEFVDEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVP 189 Query: 184 LLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVEL 243 +L++ I++ + ++VVA++NDT T+++ Y D Q ++G+I+GTG N Y + + +E Sbjct: 190 MLQEQIEKL-NIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEK 248 Query: 244 VEG-------DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGK 296 +EG + M +N E+G+F D+ L +YD ++DE S PGQQ +EK+ G Sbjct: 249 LEGLLPEDIGPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGY 307 Query: 297 YMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNIL--ST 354 Y+GE++RLVLL L D +F + +L+ +T + S++E D + + + L + Sbjct: 308 YLGEIMRLVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTN 367 Query: 355 LGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYK 414 L + + + ++R+ E V TRAA + G++ + ++ + + DGSV+ Sbjct: 368 LNIETTVVERKLIRKLAELVGTRAARLTVCGVSAICDKRGYKTAH------IAADGSVFN 421 Query: 415 LHPSFKERFHASVRRL-------TPSCEITFIESEEGSGRGAALVSAVACKK 459 +P +KE+ +++ + I + +E+GSG GAA+++ + K+ Sbjct: 422 RYPGYKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQKR 473 >3B8A-X nrPDB Length = 485 Score = 543 bits (1399), Expect = e-155, Method: Composition-based stats. Identities = 155/472 (32%), Positives = 264/472 (55%), Gaps = 33/472 (6%) Query: 6 ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 65 A + +++ Q+ F + E L+KV++ E+++GL T + ++ M+P +V Sbjct: 17 ADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGL---TKKGGNIPMIPGWVMEF 73 Query: 66 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDA-MTGTAEMLFD 124 P G E G++L++DLGGTN RV+LVK+ G + T Y +P D T E L+ Sbjct: 74 PTGKESGNYLAIDLGGTNLRVVLVKL----SGNHTFDTTQSKYKLPHDMRTTKHQEELWS 129 Query: 125 YISECISDFLDKHQMKHKK--LPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVV 182 +I++ + DF+ + ++ + K LPLGFTFS+P I++GIL WTKGF EG++VV Sbjct: 130 FIADSLKDFMVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVV 189 Query: 183 GLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVE 242 LL++ I +R + +++VA++NDTV T+I+ YY D + ++G+I GTG N + + + ++E Sbjct: 190 PLLQNEISKR-ELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIE 248 Query: 243 LVEGD-------EGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGG 295 +EG M +N E+G+F D+ L +YD VDE S PGQQ +EK+ G Sbjct: 249 KLEGKLADDIPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSG 307 Query: 296 KYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNIL--S 353 Y+GEL+RLVLL L ++ L+ + +L+ +T + +++E D + + + + Sbjct: 308 YYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQK 367 Query: 354 TLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVY 413 G++ + + ++RR CE + TRAA + G+A + + + DGSVY Sbjct: 368 DFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGH------IAADGSVY 421 Query: 414 KLHPSFKERFHASVRRL------TPSCEITFIESEEGSGRGAALVSAVACKK 459 +P FKE +R + IT + +E+GSG GAA+++A++ K+ Sbjct: 422 NKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEKR 473 >1IG8-A nrPDB Length = 486 Score = 542 bits (1396), Expect = e-154, Method: Composition-based stats. Identities = 132/457 (28%), Positives = 238/457 (52%), Gaps = 34/457 (7%) Query: 6 ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 65 A + +++E F + E L+ V + E+++GL + + ++ M+P +V Sbjct: 17 ADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDF 73 Query: 66 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDA-MTGTAEMLFD 124 P G E GDFL++DLGGTN RV+LVK+G G + T Y +P+ T + L++ Sbjct: 74 PTGKESGDFLAIDLGGTNLRVVLVKLG----GDRTFDTTQSKYRLPDAMRTTQNPDELWE 129 Query: 125 YISECISDFLDKHQMKH--KKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVV 182 +I++ + F+D+ + + +PLGFTFSFP I++GIL WTKGF E ++VV Sbjct: 130 FIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVV 189 Query: 183 GLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVE 242 +L+ I +R + ++VVA++NDT T+++ YY D + ++G+I GTG N Y + ++E Sbjct: 190 PMLQKQITKR-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIE 248 Query: 243 LVEG-------DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGG 295 ++G M +N E+G+F D+ + +YD +DE S PGQQ +EK+ G Sbjct: 249 KLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSG 307 Query: 296 KYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNIL--S 353 Y+GE++RL L+ + + +F + + +T + +++E D + + + L + Sbjct: 308 YYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQN 367 Query: 354 TLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVY 413 G+ + + ++RR E + RAA + G+A + + + DGSVY Sbjct: 368 EFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH------IAADGSVY 421 Query: 414 KLHPSFKERFHASVRRL-------TPSCEITFIESEE 443 +P FKE+ +++ + I + +E+ Sbjct: 422 NRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAED 458 >1BDG-A nrPDB Length = 451 Score = 538 bits (1386), Expect = e-153, Method: Composition-based stats. Identities = 195/452 (43%), Positives = 284/452 (62%), Gaps = 19/452 (4%) Query: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 EKV +IL F L D +++ RM + M GL+ T+E++S+KM P+YV TP G+E G+ Sbjct: 10 EKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGN 69 Query: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 FL+LDLGGTN+RV+ V + S + + + Y IP + M+G+ LF YI+E ++DF Sbjct: 70 FLALDLGGTNYRVLSVTLEGK---GKSPRIQERTYCIPAEKMSGSGTELFKYIAETLADF 126 Query: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 L+ + MK KK LGFTFSFP + + L+ WTKGF A G EG+NV LL+ + +R Sbjct: 127 LENNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKR- 185 Query: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG-DEGRMC 252 + + VA+VNDTV T+ SC ED +C VG+IVGTG N Y+E+ VEL++G E + Sbjct: 186 ELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEVV 245 Query: 253 VNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDE 312 +NTEWGAFG+ GELD + ++D+ +D S +PG+QLYEK++ G Y+GELVR +++ LV++ Sbjct: 246 INTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQ 305 Query: 313 NLLFHGEASEQLRTRGAFETRFVSQVESDTGDRK-----QIYNILSTLGLRPSTTDCDIV 367 +LF G+ E+L+ R + TR+++ VE D + + L + P D IV Sbjct: 306 KILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEP--IDNRIV 363 Query: 368 RRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASV 427 R ACE V RAA++ AG+A ++ R+ +RSE +TVGVDGS+YK HP F ER V Sbjct: 364 RYACEMVVKRAAYLAGAGIACILRRI--NRSE----VTVGVDGSLYKFHPKFCERMTDMV 417 Query: 428 RRLTPS-CEITFIESEEGSGRGAALVSAVACK 458 +L P SE+GSG+GAA ++A + Sbjct: 418 DKLKPKNTRFCLRLSEDGSGKGAAAIAASCTR 449 >5ZQT-A nrPDB Length = 473 Score = 522 bits (1345), Expect = e-148, Method: Composition-based stats. Identities = 168/476 (35%), Positives = 252/476 (52%), Gaps = 29/476 (6%) Query: 5 RARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRS 64 R M AA E+VEQ F L+ + M +EM+RGLR + H A +KML +YV + Sbjct: 8 RIPMAAAVIEEVEQ---RFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDN 62 Query: 65 TPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFD 124 P G E G F +LDLGGTNFRV+ V++G E + V +++ +IP M GT+ LFD Sbjct: 63 LPTGDEHGLFYALDLGGTNFRVIRVQLGGRE--KRVVSQQYEEVAIPPHLMVGTSMELFD 120 Query: 125 YISECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGN 179 +I+ + F+ D H + ++ LGFTFSFPV I G L+ WTKGF +G G Sbjct: 121 FIAAELESFVKTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGE 180 Query: 180 NVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQ 239 +VV L A++R+G +M V A+VNDTV T+ Y D+ +I+GTG NA Y+E Sbjct: 181 DVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHAN 239 Query: 240 NVELVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGK 296 + G G M +N EWG F S L +YD +D S NPG+Q+YEK+I G Sbjct: 240 AIPKWTGLLPRSGNMVINMEWGNF-KSERL--PRSDYDNALDFESLNPGEQIYEKMISGM 296 Query: 297 YMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTG-DRKQIYNILST- 354 Y+GE+VR +LL+L + LF +L R T +S + DT D K + L Sbjct: 297 YLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDI 356 Query: 355 LGLRPSTTDCD-IVRRACESVSTRAAHMCSAGLAGVINRMRESR----SEDVMRITVGVD 409 LG+ ++ + I C+ V+ R A + +AG+ G++ ++ R R + +D Sbjct: 357 LGVADTSLEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALD 416 Query: 410 GSVYKLHPSFKERFHASVRRLTP---SCEITFIESEEGSGRGAALVSAVACKKACM 462 G +Y+ + F+ A++ L + + + +GSG GAAL++A + A + Sbjct: 417 GGLYEHYKKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 472 >4QS9-A nrPDB Length = 474 Score = 495 bits (1274), Expect = e-140, Method: Composition-based stats. Identities = 158/466 (33%), Positives = 248/466 (53%), Gaps = 31/466 (6%) Query: 15 KVEQILAEFQLQEED-------LKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPE 67 K ++LA + EED L++V M EM GL + + +KML +YV + P Sbjct: 11 KWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGL--ASDGGSKLKMLISYVDNLPS 68 Query: 68 GSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYIS 127 G E G F +LDLGGTNFRVM V +G +E VK + + SIP MTG ++ LF++I+ Sbjct: 69 GDEKGLFYALDLGGTNFRVMRVLLGGKQE--RVVKQEFEEVSIPPHLMTGGSDELFNFIA 126 Query: 128 ECISDFL-----DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVV 182 E ++ F+ D H + ++ LGFTF+FPV+ + G L+ WTKGF A G +VV Sbjct: 127 EALAKFVATECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVV 186 Query: 183 GLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVE 242 G L A++R G +M + A+VNDTV T+ Y + +I+GTG NA Y+E + Sbjct: 187 GALNKALERVG-LDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIP 245 Query: 243 LVEG---DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMG 299 G G M +N EWG F S L E+D +D S NPG+Q+ EK+I G Y+G Sbjct: 246 KWHGLLPKSGEMVINMEWGNF-RSSHLPL--TEFDHTLDFESLNPGEQILEKIISGMYLG 302 Query: 300 ELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTG-DRKQIYNILSTLGLR 358 E++R VLL++ ++ F +LR T +S + +DT D K + + + + Sbjct: 303 EILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV 362 Query: 359 PSTTD--CDIVRRACESVSTRAAHMCSAGLAGVINRMRESR--SEDVMRITVGVDGSVYK 414 P+T+ +V C ++TR A + +AG+ G++ ++ E+V + + +DG +++ Sbjct: 363 PTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFE 422 Query: 415 LHPSFKERFHASVRRLTPSC---EITFIESEEGSGRGAALVSAVAC 457 + F E +S++ L + S +GSG GAAL++A Sbjct: 423 HYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHS 468 >2YHX-A nrPDB Length = 457 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 82/467 (17%), Positives = 158/467 (33%), Gaps = 42/467 (8%) Query: 9 EAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEG 68 A VE F + L+ V+ + AS+ M+P +V G Sbjct: 2 AAXDXSLVEVHXXVFIVPPXILQAVVSILTTRX----DDXDSSAASIPMVPGWVLKQVSG 57 Query: 69 SEVGDFLSLDLGGTNFRVMLVKVGEGEEG----QWSVKTKHQMYSIPEDAMTGTAEMLFD 124 ++ G FL++ +GG + V+L+ + +E S+ +IP D A Sbjct: 58 AQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTTAIPSDLWGNXA----- 112 Query: 125 YISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGL 184 + + +PLGFTF E + KG + F S A ++ Sbjct: 113 --XSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAF--SLAXLXKLISA 168 Query: 185 LRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNV--- 241 + +A GD VA + D+ + Y D ++G+I G+G NA Y + + Sbjct: 169 MXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWCDSTXIGDA 227 Query: 242 --ELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMG 299 G G M + + +F + Y ++ S + + K K G Sbjct: 228 ADGGXXGGAGXMXICCDQSSF-RKAFPSLPQIXYLXTLNXXSPXAXK-TFXKNSXAKNXG 285 Query: 300 ELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GDRKQIYNILS-TLGL 357 + +R VL+ H + T + ++++ D + ++ G+ Sbjct: 286 QSLRDVLMXFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFDLRXXXDLFXGDQGI 344 Query: 358 RPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHP 417 T +VRR ++ A + + + + S + GS + + Sbjct: 345 AXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSGH------IAAXGSX-RSYS 397 Query: 418 SFKERFHASVRRL-------TPSCEITFIESEEGSGRGAALVSAVAC 457 F + S I + +G G + ++ ++A Sbjct: 398 GFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIAS 444 >1HKG-A nrPDB Length = 457 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 76/421 (18%), Positives = 145/421 (34%), Gaps = 38/421 (9%) Query: 55 VKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEG----QWSVKTKHQMYSI 110 + M+P +V GS+ G FL++ +GG + V+L+ + +E S+ +I Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103 Query: 111 PEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKG 170 P D A + + +PLGFTF E + KG + Sbjct: 104 PSDLWGNXA-------XSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 171 FKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGC 230 F S A ++ + +A GD VA + D+ + Y D ++G+I G+G Sbjct: 157 F--SLAXLXKLISAMXNAXFPAGDX-XXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 231 NACYMEEMQNV-----ELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPG 285 NA Y + + G G M V +F + Y ++ S Sbjct: 214 NAAYWCDSTXIADAADAGXXGGAGXMXVCCXQDSF-RKAFPSLPQIXYXXTLNXXSPXAX 272 Query: 286 QQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT-GD 344 + +EK K G+ +R VL+ H + + + ++++ D Sbjct: 273 K-TFEKNSXAKNXGQSLRDVLMXYKXXGQX-HXXXAXDFXAANVENSSYPAKIQKLPHFD 330 Query: 345 RKQIYNILS-TLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMR 403 + ++ G+ T +VRR ++ A + + + + S Sbjct: 331 LRXXXDLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSGH---- 386 Query: 404 ITVGVDGSVYKLHPSFKERFHASVRRL-------TPSCEITFIESEEGSGRGAALVSAVA 456 + GS + + F + S I + +G G ++ ++A Sbjct: 387 --IAAXGSX-RDYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIA 443 Query: 457 C 457 Sbjct: 444 S 444 >2C7B-A nrPDB Length = 311 Score = 29.2 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 31/91 (34%), Gaps = 13/91 (14%) Query: 316 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 375 + R A E +F + VE K + + LG+ P D V Sbjct: 102 LSDSVVVSVDYRLAPEYKFPTAVEDAYAALKWVADRADELGVDP---DRIAV-------- 150 Query: 376 TRAAHMCSAGLAGVINRMRESRSEDVMRITV 406 A LA V++ + + E +++ V Sbjct: 151 --AGDSAGGNLAAVVSILDRNSGEKLVKKQV 179 >4WGK-A nrPDB Length = 688 Score = 28.8 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 23/59 (38%) Query: 17 EQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 75 + A QL K + + RG ++ V ++P+ V P+G GD L Sbjct: 503 HTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIPSIVDRAPKGRTFGDVL 561 >1R6M-A nrPDB Length = 239 Score = 28.8 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 29/72 (40%), Gaps = 8/72 (11%) Query: 351 ILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLA-----GVINRMRESRSEDVMRIT 405 LS LG DCD+++ TR A + A +A V+ + + + ++ Sbjct: 104 DLSKLGENTLYIDCDVIQADG---GTRTASITGATVALIDALAVLKKRGALKGNPLKQMV 160 Query: 406 VGVDGSVYKLHP 417 V +Y+ P Sbjct: 161 AAVSVGIYQGVP 172 >1WZC-A nrPDB Length = 249 Score = 28.4 bits (62), Expect = 6.1, Method: Composition-based stats. Identities = 16/112 (14%), Positives = 42/112 (37%), Gaps = 12/112 (10%) Query: 12 KKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEV 71 E+++ + E + +KE++ + +++ + Y +G EV Sbjct: 25 IIEELKDMGFEIIFNSSKTRAEQEYYRKELEVETPFISENGSAIFIPKGYFPFDVKGKEV 84 Query: 72 GDFLSLDLGGTNFRVMLVK---------VGEGEEGQWSVKTKHQMYSIPEDA 114 G+++ ++LG RV ++ G G + + + +P + Sbjct: 85 GNYIVIELG---IRVEKIREELKKLENIYGLKYYGNSTKEEIEKFTGMPPEL 133 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.317 0.138 0.364 Lambda K H 0.267 0.0422 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,274,509 Number of Sequences: 36641 Number of extensions: 712762 Number of successful extensions: 2078 Number of sequences better than 10.0: 20 Number of HSP's better than 10.0 without gapping: 30 Number of HSP's successfully gapped in prelim test: 17 Number of HSP's that attempted gapping in prelim test: 1916 Number of HSP's gapped (non-prelim): 58 length of query: 465 length of database: 10,336,785 effective HSP length: 101 effective length of query: 364 effective length of database: 6,636,044 effective search space: 2415520016 effective search space used: 2415520016 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 61 (28.1 bits)