BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P35184 (431 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5AMS-A nrPDB 889 0.0 2HES-X nrPDB 46 2e-05 5NNZ-B nrPDB 39 0.004 4AEZ-A nrPDB 39 0.006 6QX9-5O nrPDB 39 0.006 2YNP-A nrPDB 39 0.006 3MKQ-A nrPDB 39 0.006 6ID0-T nrPDB 37 0.012 5NZU-C nrPDB 37 0.015 6F3T-A nrPDB 37 0.023 6MZM-G nrPDB 36 0.028 5OPT-p nrPDB 36 0.038 5MZH-A nrPDB 35 0.070 4V8M-A7 nrPDB 34 0.14 5GAN-H nrPDB 34 0.16 6EMK-B nrPDB 33 0.34 6QX9-4B nrPDB 32 0.37 5FL8-q nrPDB 32 0.39 5M25-A nrPDB 32 0.41 6F1U-h nrPDB 32 0.51 5FVM-C nrPDB 32 0.67 5WLC-SG nrPDB 32 0.69 5WLC-LS nrPDB 32 0.78 2H9P-A nrPDB 31 0.84 4V7E-Bg nrPDB 31 1.2 3FM0-A nrPDB 31 1.3 2JIS-A nrPDB 31 1.3 5Y88-O nrPDB 30 1.4 3I2N-A nrPDB 30 1.9 6GMH-W nrPDB 30 1.9 6Q8F-A nrPDB 30 2.6 4J0X-A nrPDB 30 2.6 6EOJ-D nrPDB 29 4.2 4IMM-A nrPDB 29 4.2 3ACP-A nrPDB 29 4.7 5WLC-LK nrPDB 28 5.3 1NR0-A nrPDB 28 5.9 5WYJ-BC nrPDB 28 6.1 1BVU-A nrPDB 28 7.2 3EF1-A nrPDB 28 8.3 4BH6-A nrPDB 28 9.3 >5AMS-A nrPDB Length = 431 Score = 889 bits (2296), Expect = 0.0, Method: Compositional matrix adjust. Identities = 431/431 (100%), Positives = 431/431 (100%) Query: 1 MEPQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTY 60 MEPQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTY Sbjct: 1 MEPQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTY 60 Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE Sbjct: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW Sbjct: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 Query: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ 240 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ Sbjct: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ 240 Query: 241 LFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTV 300 LFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTV Sbjct: 241 LFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTV 300 Query: 301 IELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMF 360 IELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMF Sbjct: 301 IELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMF 360 Query: 361 DNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQKRKVITAGD 420 DNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQKRKVITAGD Sbjct: 361 DNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQKRKVITAGD 420 Query: 421 EGVSLVFEVPN 431 EGVSLVFEVPN Sbjct: 421 EGVSLVFEVPN 431 >2HES-X nrPDB Length = 330 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 35/238 (14%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPK-----FAGTLTGYGESVISCSFT 118 H ++ ++ P+ L+ G D+ +W + + G+ V +++ Sbjct: 57 HKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS 116 Query: 119 SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQE----VEEIVWLKTHPTIARTFAFGA 174 ++G +L T V + + G +++ S +QE V+ ++W HP+ A A + Sbjct: 117 NDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIW---HPSEA-LLASSS 172 Query: 175 TDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 D +V ++ + D +++G H+ +F DK E L + S DST+ W Sbjct: 173 YDDTVRIWKDYDDDWECVAVLNG--HEGTVWSSDF---DKTEGVFRLCSGSDDSTVRVWK 227 Query: 235 CFTGQQLFKITQAEIKGLEAPWISLSLAPETLTK-------GNSGVVACGSNNGLLAV 285 + G + + W+ ++ P+ + G +G++A +G+LAV Sbjct: 228 -YMGDD---------EDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAV 275 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 19/85 (22%), Positives = 39/85 (45%), Gaps = 4/85 (4%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 ++ +H+ V + HP+ L+ + D+ +W + + L G+ +V S F Sbjct: 146 ISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDF 205 Query: 118 -TSEGGFLVTA---DMSGKVLVHMG 138 +EG F + + D + +V +MG Sbjct: 206 DKTEGVFRLCSGSDDSTVRVWKYMG 230 >5NNZ-B nrPDB Length = 415 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 2/75 (2%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 F HT + + +P LV TG D A LW + + TL G+ +IS SF + Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY--TLRGHSAEIISLSFNTS 230 Query: 121 GGFLVTADMSGKVLV 135 G ++T V+V Sbjct: 231 GDRIITGSFDHTVVV 245 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 16/73 (21%), Positives = 32/73 (43%), Gaps = 2/73 (2%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 + + + H + I +P + TG D A +W +Q + L G+ + + Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW--DAQTGQCLQVLEGHTDEIF 391 Query: 114 SCSFTSEGGFLVT 126 SC+F +G ++T Sbjct: 392 SCAFNYKGNIVIT 404 >4AEZ-A nrPDB Length = 401 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 29/135 (21%), Positives = 56/135 (41%), Gaps = 4/135 (2%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYG 109 +V ++N+ + H+ V + + + +GG DN+ +W + S PKF T T + Sbjct: 202 DVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKF--TKTNHN 259 Query: 110 ESVISCSFTS-EGGFLVTADMSGKVLVHMGQKG-GAQWKLASQMQEVEEIVWLKTHPTIA 167 +V + ++ + L T + +H GA+ +V ++W I Sbjct: 260 AAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIM 319 Query: 168 RTFAFGATDGSVWCY 182 T F + S+W Y Sbjct: 320 STHGFPDNNLSIWSY 334 >6QX9-5O nrPDB Length = 357 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 30/124 (24%), Positives = 51/124 (41%), Gaps = 4/124 (3%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H V+ HPN + + G D L LW + +A TL G+ +V+ + ++G Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYA-TLKGHSGAVMELHYNTDGSM 123 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 L +A V V + G +L V + P + T G+ DG+V + Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT---GSDDGTVKLWD 180 Query: 184 INEQ 187 I ++ Sbjct: 181 IRKK 184 Score = 35.4 bits (80), Expect = 0.043, Method: Compositional matrix adjust. Identities = 30/141 (21%), Positives = 54/141 (38%), Gaps = 9/141 (6%) Query: 35 NDDDDEMMND--DEEALEVDMSNNSLTY-FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHL 91 ND D++++ D + D+ N LTY H DSV + + + DN + Sbjct: 202 NDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRV 261 Query: 92 WTSHSQPPK------FAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQW 145 W PK F G + + ++++ CS++ +G + V V + Sbjct: 262 WDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILY 321 Query: 146 KLASQMQEVEEIVWLKTHPTI 166 KL + E+ + P I Sbjct: 322 KLPGHAGSINEVAFHPDEPII 342 >2YNP-A nrPDB Length = 604 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 59/250 (23%), Positives = 93/250 (37%), Gaps = 34/250 (13%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 F+ H D + +I HP P V +G D LW + T G+ V+ +F + Sbjct: 93 FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENN-WALEQTFEGHEHFVMCVAFNPK 151 Query: 121 GGFLVTA---DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG 177 + D + KV +GQ Q + V ++ +P + + A+D Sbjct: 152 DPSTFASGCLDRTVKVW-SLGQSTPNFTLTTGQERGVN---YVDYYPLPDKPYMITASDD 207 Query: 178 ---SVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLE-LVTCSLDSTIVAW 233 +W YQ +LE H + S F TL +++ S D T+ W Sbjct: 208 LTIKIWDYQTKSCVATLEG------HMSNVSFAVF------HPTLPIIISGSEDGTLKIW 255 Query: 234 NCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGA 293 N T +K+ + GLE W T G +A G +NG V++ N Sbjct: 256 NSST----YKVEKTLNVGLERSW-----CIATHPTGRKNYIASGFDNG-FTVLSLGNDEP 305 Query: 294 ILHLSTVIEL 303 L L V +L Sbjct: 306 TLSLDPVGKL 315 >3MKQ-A nrPDB Length = 814 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 59/250 (23%), Positives = 93/250 (37%), Gaps = 34/250 (13%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 F+ H D + +I HP P V +G D LW + T G+ V+ +F + Sbjct: 93 FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWA-LEQTFEGHEHFVMCVAFNPK 151 Query: 121 GGFLVTA---DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG 177 + D + KV +GQ Q + V ++ +P + + A+D Sbjct: 152 DPSTFASGCLDRTVKVW-SLGQSTPNFTLTTGQERGVN---YVDYYPLPDKPYMITASDD 207 Query: 178 ---SVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLE-LVTCSLDSTIVAW 233 +W YQ +LE H + S F TL +++ S D T+ W Sbjct: 208 LTIKIWDYQTKSCVATLEG------HMSNVSFAVF------HPTLPIIISGSEDGTLKIW 255 Query: 234 NCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGA 293 N T +K+ + GLE W T G +A G +NG V++ N Sbjct: 256 NSST----YKVEKTLNVGLERSW-----CIATHPTGRKNYIASGFDNG-FTVLSLGNDEP 305 Query: 294 ILHLSTVIEL 303 L L V +L Sbjct: 306 TLSLDPVGKL 315 >6ID0-T nrPDB Length = 514 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 41/193 (21%), Positives = 77/193 (39%), Gaps = 17/193 (8%) Query: 55 NNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVIS 114 N + ++ H +V+ + HP + ++ T D+ A +W ++ TL+G+ +V + Sbjct: 278 NKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTK--ASVHTLSGHTNAVAT 335 Query: 115 CSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGA 174 + ++T + + G + L + + V +V H TFA G+ Sbjct: 336 VRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRH----YTFASGS 391 Query: 175 TDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 D Q DGS Q +SG INT + LV+ + + T+ W+ Sbjct: 392 PDN---IKQWKFPDGSFIQNLSGH--------NAIINTLTVNSDGVLVSGADNGTMHLWD 440 Query: 235 CFTGQQLFKITQA 247 TG ++ A Sbjct: 441 WRTGYNFQRVHAA 453 >5NZU-C nrPDB Length = 905 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 27/99 (27%), Positives = 42/99 (42%), Gaps = 9/99 (9%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H +V HP LP++ TG D +W HS + TL YG + C + G Sbjct: 228 HAQNVSCASFHPELPIIITGSEDGTVRIW--HSSTYRLESTL-NYGMERVWCVASLRGSN 284 Query: 124 LVTADM-SGKVLVHMGQKGGAQWKLASQMQEVEEIVWLK 161 V G ++V +G++ + A M +I+W K Sbjct: 285 NVALGYDEGSIIVKLGRE-----EPAMSMDANGKIIWAK 318 Score = 32.3 bits (72), Expect = 0.36, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 16/32 (50%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW 92 F+ H+D + I HP P + T D L LW Sbjct: 95 FEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126 >6F3T-A nrPDB Length = 608 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 24/78 (30%), Positives = 31/78 (39%), Gaps = 2/78 (2%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 L F H V HPN V TG D LW + TG+ + S +F Sbjct: 428 LRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG--NCVRIFTGHKGPIHSLTF 485 Query: 118 TSEGGFLVTADMSGKVLV 135 + G FL T G+VL+ Sbjct: 486 SPNGRFLATGATDGRVLL 503 Score = 32.3 bits (72), Expect = 0.44, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 4/82 (4%) Query: 53 MSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-TSHSQPPKFAGTLTGYGES 111 ++ N + F H + ++ PN + TG D LW H G L G+ ++ Sbjct: 465 LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL---MVGELKGHTDT 521 Query: 112 VISCSFTSEGGFLVTADMSGKV 133 V S F+ +G L + M V Sbjct: 522 VCSLRFSRDGEILASGSMDNTV 543 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 65/178 (36%), Gaps = 21/178 (11%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-TSHSQPPK-FAGTLTGYGESVISCS-F 117 + H V+ P +GG D +A LW T H QP + FAG L ++C+ F Sbjct: 389 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD-----VNCTRF 443 Query: 118 TSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG 177 ++ T V + G + + T R A GATDG Sbjct: 444 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL----TFSPNGRFLATGATDG 499 Query: 178 SVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNC 235 V + I LM G + ++ + GE L + S+D+T+ W+ Sbjct: 500 RVLLWDIG------HGLMVGELKGHTDTVCSLRFSRDGE---ILASGSMDNTVRLWDA 548 >6MZM-G nrPDB Length = 800 Score = 36.2 bits (82), Expect = 0.028, Method: Compositional matrix adjust. Identities = 24/78 (30%), Positives = 31/78 (39%), Gaps = 2/78 (2%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 L F H V HPN V TG D LW + TG+ + S +F Sbjct: 620 LRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG--NCVRIFTGHKGPIHSLTF 677 Query: 118 TSEGGFLVTADMSGKVLV 135 + G FL T G+VL+ Sbjct: 678 SPNGRFLATGATDGRVLL 695 Score = 32.3 bits (72), Expect = 0.45, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 34/82 (41%), Gaps = 4/82 (4%) Query: 53 MSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-TSHSQPPKFAGTLTGYGES 111 ++ N + F H + ++ PN + TG D LW H G L G+ ++ Sbjct: 657 LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL---MVGELKGHTDT 713 Query: 112 VISCSFTSEGGFLVTADMSGKV 133 V S F+ +G L + M V Sbjct: 714 VCSLRFSRDGEILASGSMDNTV 735 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 42/181 (23%), Positives = 66/181 (36%), Gaps = 21/181 (11%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-TSHSQPPK-FAGTLTGYGESVISC 115 L + H V+ P +GG D +A LW T H QP + FAG L ++C Sbjct: 578 LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD-----VNC 632 Query: 116 S-FTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGA 174 + F ++ T V + G + + + R A GA Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPN----GRFLATGA 688 Query: 175 TDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 TDG V + I LM G + ++ + GE L + S+D+T+ W+ Sbjct: 689 TDGRVLLWDIG------HGLMVGELKGHTDTVCSLRFSRDGEI---LASGSMDNTVRLWD 739 Query: 235 C 235 Sbjct: 740 A 740 >5OPT-p nrPDB Length = 318 Score = 35.8 bits (81), Expect = 0.038, Method: Compositional matrix adjust. Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 4/88 (4%) Query: 64 HTDSVFAIGHHPNL--PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEG 121 HTD V + P+L PL+ +GG DNL +W S + L G+ + S + + +G Sbjct: 151 HTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASG--RLLTDLKGHTNYITSVTVSPDG 208 Query: 122 GFLVTADMSGKVLVHMGQKGGAQWKLAS 149 ++D G + KG A ++A+ Sbjct: 209 SLCASSDKDGVARLWDLTKGEALSEMAA 236 >5MZH-A nrPDB Length = 452 Score = 35.0 bits (79), Expect = 0.070, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 49/115 (42%), Gaps = 5/115 (4%) Query: 16 EIVPTVEVEQDVPVDIEGENDDDDEMMND--DEEALEVDMSNNSLTYFDK-HTDSVFAIG 72 E V T+E ++V I N D+++ D+ D L Y K H + + Sbjct: 127 EEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLS 186 Query: 73 HHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTA 127 +P ++ TG DN A LW + + TL G+ ++S F + G +VT Sbjct: 187 FNPQSTIIATGSMDNTAKLWDVETGQER--ATLAGHRAEIVSLGFNTGGDLIVTG 239 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 11/59 (18%) Query: 220 ELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGS 278 ++VT S D T W+ +TGQ + +KG + + LS P+ S ++A GS Sbjct: 151 KIVTGSFDKTCKLWDAYTGQLYYT-----LKGHQTEIVCLSFNPQ------STIIATGS 198 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 15/64 (23%), Positives = 27/64 (42%), Gaps = 2/64 (3%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H + + +P + T D LW + + L G+ + + SC+F EG F Sbjct: 346 HEGEISKVAFNPQGTRLITASSDKTCRLWDCDT--GECLQVLEGHTDEIFSCAFNYEGDF 403 Query: 124 LVTA 127 ++T Sbjct: 404 IITG 407 >4V8M-A7 nrPDB Length = 318 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 24/88 (27%), Positives = 42/88 (47%), Gaps = 4/88 (4%) Query: 64 HTDSVFAIGHHPNL--PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEG 121 HTD V + P+L P++ +GG DNL +W + + L G+ V S + + +G Sbjct: 151 HTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATG--RLVTDLKGHTNYVTSVTVSPDG 208 Query: 122 GFLVTADMSGKVLVHMGQKGGAQWKLAS 149 ++D G + KG A ++A+ Sbjct: 209 SLCASSDKDGVARLWDLTKGEALSEMAA 236 >5GAN-H nrPDB Length = 465 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 41/182 (22%), Positives = 72/182 (39%), Gaps = 33/182 (18%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H VF++ + LVC+GG D+L+ LW S TL G+ + + + +++ G Sbjct: 306 HDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVM--TLAGHSKPIYTVAWSPNGYQ 363 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQ-EVEEIVWLKTHPTIARTFAFGATDGS---V 179 + T G + V W + + + ++ +I+ H I F DG V Sbjct: 364 VATGGGDGIINV---------WDIRKRDEGQLNQIL---AHRNIVTQVRFSKEDGGKKLV 411 Query: 180 WCYQINEQDGSLEQLMSGFVHQQDCSMG-------EFINTDKGENTLELVTCSLDSTIVA 232 C + L++ + MG + I+ D N+ LV+ D +I Sbjct: 412 SC--------GYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKL 463 Query: 233 WN 234 WN Sbjct: 464 WN 465 >6EMK-B nrPDB Length = 303 Score = 32.7 bits (73), Expect = 0.34, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 1/70 (1%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 +T F H+ + I ++ + T D+ A +W S K TL G+ V C+F Sbjct: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVW-SIDDDFKLETTLDGHQRWVWDCAF 258 Query: 118 TSEGGFLVTA 127 +++ +LVTA Sbjct: 259 SADSAYLVTA 268 >6QX9-4B nrPDB Length = 522 Score = 32.3 bits (72), Expect = 0.37, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 35/84 (41%), Gaps = 5/84 (5%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 + + + H ++ I PN + TG GDN +W + + T+ + V F Sbjct: 400 IMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQR--RCVYTIPAHQNLVTGVKF 457 Query: 118 TS-EGGFLVTA--DMSGKVLVHMG 138 G FL+T D + K+ H G Sbjct: 458 EPIHGNFLLTGAYDNTAKIWTHPG 481 >5FL8-q nrPDB Length = 515 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 24/104 (23%), Positives = 43/104 (41%), Gaps = 5/104 (4%) Query: 33 GENDDDDE--MMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLP-LVCTGGGDNLA 89 G N +D+ ++ +V S + H ++ P+ + TG GDN A Sbjct: 109 GYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTA 168 Query: 90 HLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKV 133 +W +Q P TL G+ V+ S++ +G + T M + Sbjct: 169 RIWDCDTQTPMH--TLKGHYNWVLCVSWSPDGEVIATGSMDNTI 210 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 21/88 (23%), Positives = 34/88 (38%), Gaps = 8/88 (9%) Query: 6 EFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTYFDKHT 65 +FI+T V V D + + D ++ + L VD+ H Sbjct: 435 KFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPG--------HK 486 Query: 66 DSVFAIGHHPNLPLVCTGGGDNLAHLWT 93 D V+ + + VC+GG D + LWT Sbjct: 487 DEVYTVDWSVDGKRVCSGGKDKMVRLWT 514 >5M25-A nrPDB Length = 434 Score = 32.3 bits (72), Expect = 0.41, Method: Compositional matrix adjust. Identities = 16/64 (25%), Positives = 33/64 (51%), Gaps = 2/64 (3%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 HT +V ++ PN + + D L +W ++ KF T++G+ + +++S+ Sbjct: 144 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSNL 201 Query: 124 LVTA 127 LV+A Sbjct: 202 LVSA 205 >6F1U-h nrPDB Length = 612 Score = 32.0 bits (71), Expect = 0.51, Method: Compositional matrix adjust. Identities = 25/119 (21%), Positives = 45/119 (37%), Gaps = 17/119 (14%) Query: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNN 280 VT S D T+ W+ + L+ + W + + + AC Sbjct: 471 FVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMW----------SPTHPALFACVDGM 520 Query: 281 GLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYD 339 G L + N NN + S +E P ++ + W+ +A+G G+I++YD Sbjct: 521 GRLDLWNLNNDTEVPTASISVEGNP-------ALNRVRWTHSGREIAVGDSEGQIVIYD 572 >5FVM-C nrPDB Length = 303 Score = 31.6 bits (70), Expect = 0.67, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 +T F HT + + ++ + T D+ A +W + TL G+ V C+F Sbjct: 200 VTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNY-QLETTLDGHQRWVWDCAF 258 Query: 118 TSEGGFLVTA 127 +++ +LVTA Sbjct: 259 SADSAYLVTA 268 >5WLC-SG nrPDB Length = 573 Score = 31.6 bits (70), Expect = 0.69, Method: Compositional matrix adjust. Identities = 30/125 (24%), Positives = 49/125 (39%), Gaps = 6/125 (4%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHS-QPPKFAGTLTGYGESVISCSFTSEGG 122 H D + + P+ V TGG D +W++ S P K T GE V+S +F Sbjct: 235 HYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGE-VLSLAFRKNSD 293 Query: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 L + K+ + + L VE+I L + R GA D + + Sbjct: 294 QLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISAL----AMERCVTVGARDRTAMLW 349 Query: 183 QINEQ 187 +I ++ Sbjct: 350 KIPDE 354 >5WLC-LS nrPDB Length = 594 Score = 31.6 bits (70), Expect = 0.78, Method: Compositional matrix adjust. Identities = 22/111 (19%), Positives = 49/111 (44%), Gaps = 12/111 (10%) Query: 67 SVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVT 126 ++ ++ HP+ PL+ TGG D ++ + +L G + +C+F + Sbjct: 250 AIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTF-----YTSL 304 Query: 127 ADMSGKVLVHMGQKGGAQ-WKLA------SQMQEVEEIVWLKTHPTIARTF 170 ++ + + + G++ W L+ SQ ++E+ L H + R+F Sbjct: 305 SNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSF 355 >2H9P-A nrPDB Length = 329 Score = 31.2 bits (69), Expect = 0.84, Method: Compositional matrix adjust. Identities = 16/64 (25%), Positives = 33/64 (51%), Gaps = 2/64 (3%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 HT +V ++ PN + + D L +W ++ KF T++G+ + +++S+ Sbjct: 39 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSNL 96 Query: 124 LVTA 127 LV+A Sbjct: 97 LVSA 100 >4V7E-Bg nrPDB Length = 380 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 72/173 (41%), Gaps = 35/173 (20%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWK-LASQMQEVEEIVWLKT 162 TL G+ V S +T E ++V+A G+++V W L SQ +K Sbjct: 61 TLQGHSGKVYSLDWTPEKNWIVSASQDGRLIV---------WNALTSQKTHA-----IKL 106 Query: 163 HPTIARTFAFGATDGSVWCYQIN------------EQDGSL--EQLMSGFVHQQDCSMGE 208 H AF SV C ++ ++DG++ ++++G H+ S + Sbjct: 107 HCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTG--HKGYASSCQ 164 Query: 209 FINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSL 261 ++ + L+T S D T V W+ TGQ++ G A +SLS+ Sbjct: 165 YVP----DQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSI 213 >3FM0-A nrPDB Length = 345 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 26/129 (20%), Positives = 53/129 (41%), Gaps = 8/129 (6%) Query: 64 HTDS-VFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLT-GYGESVISCSFTSEG 121 H DS + + +P L+ + GGD +W + L+ G+ +V +++ G Sbjct: 14 HPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCG 73 Query: 122 GFLVTADMSGKVLVHMGQKGGAQW--KLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 +L +A + + + L EV+ + W + A + D SV Sbjct: 74 NYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS----GNLLATCSRDKSV 129 Query: 180 WCYQINEQD 188 W ++++E+D Sbjct: 130 WVWEVDEED 138 >2JIS-A nrPDB Length = 515 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 25/84 (29%), Positives = 40/84 (47%), Gaps = 9/84 (10%) Query: 266 LTKGNSGVVACGSNNGLLAVIN-CNNGGAILHL-----STVIELKPEQDELDA--SIESI 317 L SG G+ + L A+ + C G LH+ +V+ + + LD +S+ Sbjct: 262 LVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSV 321 Query: 318 SWSSKFSLMAIGLVCGEILLYDTS 341 +W+ L+A GL C +LL DTS Sbjct: 322 AWNPH-KLLAAGLQCSALLLQDTS 344 >5Y88-O nrPDB Length = 451 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 15/45 (33%), Positives = 22/45 (48%), Gaps = 2/45 (4%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGY 108 H V + HP L L+ T G D++ LW ++ P TL G+ Sbjct: 223 HLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVI--TLVGH 265 >3I2N-A nrPDB Length = 357 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 22/91 (24%), Positives = 44/91 (48%), Gaps = 9/91 (9%) Query: 300 VIELKPEQDELDASIESISWSSKFS----LMAIGLVCGEILLYDTSAWRVRHKFVLEDSV 355 V ++P Q E ++++ + ++ ++ G G+I L+D +R + +++ V Sbjct: 153 VANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNGV 212 Query: 356 TKLMFDNDD-----LFASCINGKVYQFNART 381 L FD D L A+ + GK + F+ RT Sbjct: 213 CSLEFDRKDISMNKLVATSLEGKFHVFDMRT 243 >6GMH-W nrPDB Length = 305 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 50/224 (22%), Positives = 98/224 (43%), Gaps = 36/224 (16%) Query: 212 TDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNS 271 T+K EN+ +VT SLD + W + ++L Q ++G + +S+ ++ TL Sbjct: 26 TNKKENSETVVTGSLDDLVKVWK-WRDERL--DLQWSLEGHQLGVVSVDIS-HTLP---- 77 Query: 272 GVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLV 331 + A S + + + + NG I I+ P +DA + S S++ +A G Sbjct: 78 -IAASSSLDAHIRLWDLENGKQI----KSIDAGP----VDAWTLAFSPDSQY--LATGTH 126 Query: 332 CGEILLYDTSAWR------VRHKFVLEDSVTKLMFDNDDLFASCINGKVYQFNARTGQEK 385 G++ ++ + + R KF+L + + D L + I+G + F+ TG+ Sbjct: 127 VGKVNIFGVESGKKEYSLDTRGKFILSIAYSP---DGKYLASGAIDGIINIFDIATGKLL 183 Query: 386 FVCVGHNMGVLDFILLHPVANTGTEQKRKVITAGDEGVSLVFEV 429 GH M + T + + ++TA D+G +++V Sbjct: 184 HTLEGHAMPIRSL--------TFSPDSQLLVTASDDGYIKIYDV 219 >6Q8F-A nrPDB Length = 514 Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust. Identities = 12/29 (41%), Positives = 14/29 (48%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLW 92 H V I HHP+ L+ T D L LW Sbjct: 484 HEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 >4J0X-A nrPDB Length = 451 Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust. Identities = 30/125 (24%), Positives = 49/125 (39%), Gaps = 6/125 (4%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHS-QPPKFAGTLTGYGESVISCSFTSEGG 122 H D + + P+ V TGG D +W++ S P K T GE V+S +F Sbjct: 113 HYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGE-VLSLAFRKNSD 171 Query: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 L + K+ + + L VE+I L + R GA D + + Sbjct: 172 QLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISAL----AMERCVTVGARDRTAMLW 227 Query: 183 QINEQ 187 +I ++ Sbjct: 228 KIPDE 232 >6EOJ-D nrPDB Length = 470 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 51/230 (22%), Positives = 88/230 (38%), Gaps = 36/230 (15%) Query: 77 LPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI-SCSFTSEGGFLVTADMSGKVLV 135 +P G D + +L P KF + + VI + +T EG LV A SG+ + Sbjct: 66 MPPNAYRGRDRVINL------PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSL 119 Query: 136 HMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLM 195 + + + MQ + V + + G DG + +Q N Sbjct: 120 W----NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN---------- 165 Query: 196 SGFVHQQDCSMGEFI-NTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEA 254 V + D + E I + N + VTCS D+ + WN G+Q + + G Sbjct: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ-----ERVLSGHHW 220 Query: 255 PWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELK 304 S PE G++A S + L+ + + +G I S++++ K Sbjct: 221 DVKSCDWHPEM------GLIASASKDNLVKLWDPRSGNCI---SSILKFK 261 >4IMM-A nrPDB Length = 399 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 45/206 (21%), Positives = 77/206 (37%), Gaps = 58/206 (28%) Query: 141 GGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGS-----------VWCYQINEQDG 189 G W+ A+Q+ K ART G DG VW ++ G Sbjct: 181 GATVWQYATQVPNTSVRGMAKPLALDARTVLIGGADGRIHALDTMTGAPVWTRRVGLAMG 240 Query: 190 S--LEQL------------------MSGFVHQQDCSMGEFINTDKGENTLELVT------ 223 S ++QL SG + D + G + + +T +L T Sbjct: 241 SGEIDQLRDIDGTPTVVDHYLYAASYSGQLAGFDMTTGRTMFVSELSSTKKLTTLADAVI 300 Query: 224 -CSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGL 282 S D +VA+N TG++L++ + +GL P +T G +A G +G+ Sbjct: 301 GSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNP----------VTIGT--YIAVGDADGV 348 Query: 283 LAVIN--------CNNGGAILHLSTV 300 + ++N N GA+ +L+ + Sbjct: 349 VHILNHQGQIISRANTKGALTNLTVI 374 >3ACP-A nrPDB Length = 417 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 40/95 (42%), Gaps = 10/95 (10%) Query: 154 VEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTD 213 V EI LK P+ + D + + + +DGS + + G ++ + D Sbjct: 136 VSEITKLKFFPS-GEALISSSQDMQLKIWSV--KDGSNPRTLIG----HRATVTDIAIID 188 Query: 214 KGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAE 248 +G N L + SLD TI W C TG + + E Sbjct: 189 RGRNVL---SASLDGTIRLWECGTGTTIHTFNRKE 220 >5WLC-LK nrPDB Length = 575 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 30/137 (21%), Positives = 53/137 (38%), Gaps = 20/137 (14%) Query: 57 SLTYFDKHTDSV--FAIGHHPNLPLVCTGGGDNLAHLWTSHSQPP-KFAGTLTGYGESVI 113 + T D D + F I H LVC + + S +P K++ ++ + Sbjct: 163 TFTLVDGKDDEIVHFQILHQNGTLLVCIITKQMVYIVDPSKRRPSTKYSFEISD----AV 218 Query: 114 SCSFTSEGGFLVTADMSGKVLVHMGQKGG--AQWKLASQMQEVEEIVWLKTHPTIARTFA 171 +C F+S+G +L+ A+ + + + W V +KT T+ Sbjct: 219 ACEFSSDGKYLLIANNEELIAYDLKEDSKLIQSWP-----------VQVKTLKTLDDLIM 267 Query: 172 FGATDGSVWCYQINEQD 188 TDG + Y+I E D Sbjct: 268 ALTTDGKINNYKIGEAD 284 >1NR0-A nrPDB Length = 611 Score = 28.5 bits (62), Expect = 5.9, Method: Compositional matrix adjust. Identities = 36/157 (22%), Positives = 59/157 (37%), Gaps = 9/157 (5%) Query: 79 LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMG 138 V GG D+ H++ T+ E + S +F++ G FLV D S KV+ + Sbjct: 462 FVAVGGQDSKVHVYKLSGASVSEVKTIVHPAE-ITSVAFSNNGAFLVATDQSRKVIPYSV 520 Query: 139 QKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGF 198 S ++ + P R A G+ D SV + +N+ S ++ Sbjct: 521 ANNFELAHTNSWTFHTAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKP--SDHPIIIKG 577 Query: 199 VHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNC 235 H +N+ N +V+ DS I WN Sbjct: 578 AHAMSS-----VNSVIWLNETTIVSAGQDSNIKFWNV 609 >5WYJ-BC nrPDB Length = 817 Score = 28.5 bits (62), Expect = 6.1, Method: Compositional matrix adjust. Identities = 35/156 (22%), Positives = 52/156 (33%), Gaps = 30/156 (19%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H + A+ PN + T D +W + + + TL + + SF Sbjct: 490 HEKDINALSVSPNDSIFATASYDKTCKIW--NLENGELEATLANHKRGLWDVSFCQYDKL 547 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLA--SQMQEVEEIVWLKTHPTIARTFAFGATDGSVWC 181 L T+ G K W L S M+ +E G T+ C Sbjct: 548 LATSS---------GDKTVKIWSLDTFSVMKTLE-----------------GHTNAVQRC 581 Query: 182 YQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGEN 217 IN+Q + G + DCS GE + T G N Sbjct: 582 SFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHN 617 >1BVU-A nrPDB Length = 418 Score = 28.1 bits (61), Expect = 7.2, Method: Compositional matrix adjust. Identities = 16/61 (26%), Positives = 23/61 (37%) Query: 140 KGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFV 199 KGG +W + V+ + T T +G G V C D E+L G+V Sbjct: 68 KGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGVICNPKEMSDREKERLARGYV 127 Query: 200 H 200 Sbjct: 128 R 128 >3EF1-A nrPDB Length = 442 Score = 28.1 bits (61), Expect = 8.3, Method: Compositional matrix adjust. Identities = 17/40 (42%), Positives = 25/40 (62%), Gaps = 1/40 (2%) Query: 19 PTVEVEQDVPVDI-EGENDDDDEMMNDDEEALEVDMSNNS 57 P E EQ +P++I + E D DE+ ++EE E D SN+S Sbjct: 196 PLPEQEQLIPLEIPKDEPDSVDEINEENEETPEYDSSNSS 235 >4BH6-A nrPDB Length = 308 Score = 27.7 bits (60), Expect = 9.3, Method: Compositional matrix adjust. Identities = 22/102 (21%), Positives = 44/102 (43%), Gaps = 12/102 (11%) Query: 238 GQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHL 297 G+Q +I + + L+AP ++ + ++ V+A + + NN G ++HL Sbjct: 1 GKQFRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIF--LTDNNTGDVVHL 58 Query: 298 STVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYD 339 + + S+SW S +A+G G + +YD Sbjct: 59 C----------DTENEYTSLSWIGAGSHLAVGQANGLVEIYD 90 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5AMS-A nrPDB 823 0.0 2HES-X nrPDB 295 2e-80 Sequences not found previously or not previously below threshold: 3FM0-A nrPDB 157 1e-38 5M25-A nrPDB 79 5e-15 2H9P-A nrPDB 79 5e-15 3MKQ-A nrPDB 78 7e-15 2YNP-A nrPDB 78 7e-15 5FL8-q nrPDB 78 9e-15 5MZH-A nrPDB 74 9e-14 1VYH-C nrPDB 71 1e-12 5NNZ-B nrPDB 69 5e-12 6QX9-5O nrPDB 65 7e-11 6QX9-4B nrPDB 65 7e-11 5NZU-C nrPDB 62 4e-10 4YCZ-A nrPDB 62 5e-10 4AEZ-A nrPDB 62 6e-10 5GAN-H nrPDB 62 6e-10 6HQA-B nrPDB 61 8e-10 6ID0-T nrPDB 61 9e-10 4L9O-A nrPDB 61 1e-09 4V7E-Bg nrPDB 60 2e-09 5Z56-q nrPDB 60 2e-09 4LG8-A nrPDB 60 2e-09 6MZM-G nrPDB 60 2e-09 3JRO-A nrPDB 60 2e-09 6BX3-A nrPDB 59 3e-09 5WYJ-BC nrPDB 59 4e-09 5WJC-A nrPDB 59 4e-09 6F3T-A nrPDB 59 5e-09 3BG0-A nrPDB 58 7e-09 3JRP-A nrPDB 58 8e-09 4J0W-A nrPDB 57 2e-08 4BZK-B nrPDB 57 2e-08 4V8M-A7 nrPDB 57 2e-08 6EOJ-D nrPDB 56 3e-08 5LCW-Q nrPDB 56 5e-08 5G04-R nrPDB 56 5e-08 4N14-A nrPDB 56 5e-08 4GGA-A nrPDB 56 5e-08 5L9T-R nrPDB 55 7e-08 4XYI-A nrPDB 54 9e-08 6EMK-B nrPDB 54 1e-07 5A9Q-7 nrPDB 54 1e-07 3JB9-g nrPDB 54 2e-07 6HHQ-h nrPDB 53 2e-07 5OPT-p nrPDB 53 2e-07 3DM0-A nrPDB 53 2e-07 5WLC-LO nrPDB 53 2e-07 5I2T-A nrPDB 53 2e-07 6CHG-A nrPDB 53 3e-07 4V6W-Ag nrPDB 52 4e-07 5OQL-J nrPDB 52 7e-07 5XYI-g nrPDB 51 1e-06 3F3P-A nrPDB 51 1e-06 5K1B-B nrPDB 50 1e-06 4XFV-A nrPDB 50 2e-06 6QDV-o nrPDB 50 2e-06 5YZG-W nrPDB 50 2e-06 5WYK-BB nrPDB 50 2e-06 5Y88-O nrPDB 49 3e-06 2PM9-A nrPDB 49 6e-06 3JAP-g nrPDB 49 6e-06 5A31-R nrPDB 48 6e-06 4BH6-A nrPDB 48 6e-06 5FVM-C nrPDB 48 8e-06 3JB9-L nrPDB 48 9e-06 4A11-B nrPDB 47 1e-05 2P9P-C nrPDB 47 2e-05 6G51-g nrPDB 46 3e-05 1NR0-A nrPDB 46 3e-05 6N9G-C nrPDB 46 4e-05 3C9C-A nrPDB 46 4e-05 5WLC-LW nrPDB 46 4e-05 6Q8F-A nrPDB 46 4e-05 5OQL-d nrPDB 46 4e-05 6GMH-W nrPDB 45 4e-05 3CFV-B nrPDB 45 5e-05 2AQ5-A nrPDB 45 7e-05 5OQL-L nrPDB 44 1e-04 5Y1U-A nrPDB 44 2e-04 3JZG-A nrPDB 43 3e-04 6J6H-n nrPDB 42 3e-04 5UZ7-B nrPDB 42 4e-04 5WLC-SG nrPDB 42 4e-04 4J0X-A nrPDB 42 4e-04 5N4A-A nrPDB 42 7e-04 3ACP-A nrPDB 41 0.001 1PI6-A nrPDB 39 0.003 4OWR-A nrPDB 39 0.003 3ODT-A nrPDB 39 0.003 3W15-A nrPDB 39 0.005 6E29-D nrPDB 39 0.005 5TF2-A nrPDB 38 0.009 6ELZ-p nrPDB 37 0.012 5BJS-A nrPDB 37 0.013 5WBU-D nrPDB 37 0.020 5FA5-B nrPDB 37 0.021 4BTS-AR nrPDB 36 0.024 5A9Q-0 nrPDB 36 0.037 4U1E-I nrPDB 36 0.040 6CHG-D nrPDB 36 0.041 6EM1-m nrPDB 35 0.044 6CB1-s nrPDB 35 0.044 6C0F-s nrPDB 35 0.044 3DWL-C nrPDB 35 0.060 5WLC-LS nrPDB 35 0.068 5CXC-A nrPDB 34 0.13 2XOT-A nrPDB 34 0.13 5MWJ-A nrPDB 34 0.13 3JB9-S nrPDB 34 0.13 5OQL-X nrPDB 34 0.14 5K0Y-T nrPDB 33 0.23 3EF1-A nrPDB 33 0.23 6F1U-h nrPDB 33 0.32 5WLC-LU nrPDB 33 0.33 5CXB-B nrPDB 32 0.39 5OV3-A nrPDB 32 0.56 1P49-A nrPDB 32 0.70 6BX3-B nrPDB 32 0.73 5A9Q-2 nrPDB 31 1.3 3I2N-A nrPDB 31 1.3 5WLC-LH nrPDB 30 2.0 4PSX-B nrPDB 30 2.1 2HNK-A nrPDB 29 3.1 5K19-A nrPDB 29 3.3 3VX8-B nrPDB 29 3.8 5WLC-LK nrPDB 29 4.2 2JIS-A nrPDB 29 4.3 5WLC-LN nrPDB 29 5.4 5LTD-A nrPDB 28 8.7 6HQA-J nrPDB 28 9.7 5UJS-A nrPDB 28 10.0 >5AMS-A nrPDB Length = 431 Score = 823 bits (2127), Expect = 0.0, Method: Composition-based stats. Identities = 431/431 (100%), Positives = 431/431 (100%) Query: 1 MEPQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTY 60 MEPQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTY Sbjct: 1 MEPQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTY 60 Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE Sbjct: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW Sbjct: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 Query: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ 240 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ Sbjct: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ 240 Query: 241 LFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTV 300 LFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTV Sbjct: 241 LFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTV 300 Query: 301 IELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMF 360 IELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMF Sbjct: 301 IELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLMF 360 Query: 361 DNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQKRKVITAGD 420 DNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQKRKVITAGD Sbjct: 361 DNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQKRKVITAGD 420 Query: 421 EGVSLVFEVPN 431 EGVSLVFEVPN Sbjct: 421 EGVSLVFEVPN 431 >2HES-X nrPDB Length = 330 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 47/238 (19%), Positives = 99/238 (41%), Gaps = 35/238 (14%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPK-----FAGTLTGYGESVISCSFT 118 H ++ ++ P+ L+ G D+ +W + + G+ V +++ Sbjct: 57 HKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS 116 Query: 119 SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQE----VEEIVWLKTHPTIARTFAFGA 174 ++G +L T V + + G +++ S +QE V+ ++W HP+ A A + Sbjct: 117 NDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIW---HPSEA-LLASSS 172 Query: 175 TDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 D +V ++ + D +++G H+ +F DK E L + S DST+ W Sbjct: 173 YDDTVRIWKDYDDDWECVAVLNG--HEGTVWSSDF---DKTEGVFRLCSGSDDSTVRVWK 227 Query: 235 CFTGQQLFKITQAEIKGLEAPWISLSLAPETLTK-------GNSGVVACGSNNGLLAV 285 + G + + W+ ++ P+ + G +G++A +G+LAV Sbjct: 228 -YMGDD---------EDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAV 275 Score = 67.1 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 22/160 (13%), Positives = 53/160 (33%), Gaps = 12/160 (7%) Query: 46 EEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF--AG 103 EE+ + + L + H + V + + + T D +W + ++ Sbjct: 88 EESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECIS 147 Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 L + + V + L ++ V + + W+ + + E VW Sbjct: 148 VLQEHSQDVKHVIWHPSEALLASSSYDDTVRIW--KDYDDDWECVAVLNGHEGTVWSSDF 205 Query: 164 PTIARTF--AFGATDGSVWCYQ------INEQDGSLEQLM 195 F G+ D +V ++ ++Q+ E ++ Sbjct: 206 DKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAIL 245 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 28/183 (15%), Positives = 58/183 (31%), Gaps = 9/183 (4%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 ++ +H+ V + HP+ L+ + D+ +W + + L G+ +V S F Sbjct: 146 ISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDF 205 Query: 118 TSEGGFLVTADMSG----KVLVHMGQKGG--AQWKLASQMQEVEEIVWLKTHPTIARTFA 171 G S +V +MG +W + + +V + A Sbjct: 206 DKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIA 265 Query: 172 FGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIV 231 DG + Y+ + + + H + + L T D + Sbjct: 266 SVGADGVLAVYEEVDGEWKVFA-KRALCH--GVYEINVVKWLELNGKTILATGGDDGIVN 322 Query: 232 AWN 234 W+ Sbjct: 323 FWS 325 >3FM0-A nrPDB Length = 345 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 74/209 (35%), Gaps = 19/209 (9%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H +V + P + + D +W + + TL G+ V S ++ G Sbjct: 60 HQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNL 119 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQM----QEVEEIVWLKTHPTIARTFAFGATDGSV 179 L T V V + +++ S + Q+V+ +VW HP+ A + D +V Sbjct: 120 LATCSRDKSVWVWEVDEE-DEYECVSVLNSHTQDVKHVVW---HPSQ-ELLASASYDDTV 174 Query: 180 WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQ 239 Y+ E D + G H+ F + + L +CS D T+ W + Sbjct: 175 KLYREEEDDWVCCATLEG--HESTVWSLAFDPSGQ-----RLASCSDDRTVRIWRQYLPG 227 Query: 240 QLFKITQAEIKGLEAPWISLSLAPETLTK 268 + + G + W + ++ Sbjct: 228 NEQGVACS---GSDPSWKCICTLSGFHSR 253 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 39/205 (19%), Positives = 71/205 (34%), Gaps = 25/205 (12%) Query: 50 EVDMSNN--SLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTG 107 EVD + ++ + HT V + HP+ L+ + D+ L+ TL G Sbjct: 133 EVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEG 192 Query: 108 YGESVISCSFTSEGGFLVTADMSGKVLVHM----GQKGG-------AQWKLASQM----- 151 + +V S +F G L + V + G + G WK + Sbjct: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHS 252 Query: 152 QEVEEIVWLKTHPTIARTFAFGATDGSVWCYQI--NEQDGSLEQLMSGFVHQQDCSMGEF 209 + + +I W + + A D ++ +Q N ++ +HQ Sbjct: 253 RTIYDIAWCQ----LTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308 Query: 210 INTDKGENTLELVTCSLDSTIVAWN 234 + + E L L +CS D + W Sbjct: 309 VAWNPKEPGL-LASCSDDGEVAFWK 332 Score = 72.8 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 39/245 (15%), Positives = 79/245 (32%), Gaps = 31/245 (12%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-TSHSQPPKFAGTLTGYGESVISCS 116 +T + H + V ++ P+ L+ T D +W + L + + V Sbjct: 98 VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVV 157 Query: 117 FTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATD 176 + L +A V ++ ++ W + ++ E VW + A + D Sbjct: 158 WHPSQELLASASYDDTVKLYREEE--DDWVCCATLEGHESTVWSLAFDPSGQRLASCSDD 215 Query: 177 GSVWCYQIN-------------EQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 +V ++ + +SGF H + + T L T Sbjct: 216 RTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGF-HSRTIYDIAWCQL-----TGALAT 269 Query: 224 CSLDSTIVAW----NCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSN 279 D I + N Q F +T + ++ P+ G++A S+ Sbjct: 270 ACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK-----EPGLLASCSD 324 Query: 280 NGLLA 284 +G +A Sbjct: 325 DGEVA 329 Score = 32.8 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 18/105 (17%), Positives = 32/105 (30%), Gaps = 9/105 (8%) Query: 159 WLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENT 218 W A D + + + ++S HQ+ + Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-EGHQRTVRKVAWSPCGN---- 74 Query: 219 LELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAP 263 L + S D+T W Q F+ ++G E S++ AP Sbjct: 75 -YLASASFDATTCIWK--KNQDDFECVTT-LEGHENEVKSVAWAP 115 >5M25-A nrPDB Length = 434 Score = 78.6 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 37/192 (19%), Positives = 73/192 (38%), Gaps = 19/192 (9%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 HT +V ++ PN + + D L +W ++ KF T++G+ + +++S+ Sbjct: 144 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSNL 201 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 LV+A + + G K ++ V+ + G+ D SV + Sbjct: 202 LVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 257 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFK 243 + + G + + H S F + +L +V+ S D W+ +GQ L Sbjct: 258 V--KTGKCLKTL--PAHSDPVSAVHFNR----DGSL-IVSSSYDGLCRIWDTASGQCL-- 306 Query: 244 ITQAEIKGLEAP 255 + I P Sbjct: 307 --KTLIDDDNPP 316 Score = 69.0 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 40/219 (18%), Positives = 88/219 (40%), Gaps = 17/219 (7%) Query: 30 DIEGENDDDDEMMNDDEEALEV-DMSNNS-LTYFDKHTDSVFAIGHHPNLPLVCTGGGDN 87 D+ +D + + D++ L++ D+S+ L H++ VF +P L+ +G D Sbjct: 192 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 251 Query: 88 LAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKL 147 +W + K TL + + V + F +G +V++ G + G + Sbjct: 252 SVRIW--DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG----QC 305 Query: 148 ASQMQEVEE--IVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCS 205 + + + + ++K P A D ++ + + G + +G +++ C Sbjct: 306 LKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLW-DYSK-GKCLKTYTGHKNEKYCI 362 Query: 206 MGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKI 244 F T +V+ S D+ + WN T + + K+ Sbjct: 363 FANFSVT----GGKWIVSGSEDNLVYIWNLQTKEIVQKL 397 >2H9P-A nrPDB Length = 329 Score = 78.6 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 37/192 (19%), Positives = 73/192 (38%), Gaps = 19/192 (9%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 HT +V ++ PN + + D L +W ++ KF T++G+ + +++S+ Sbjct: 39 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSNL 96 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 LV+A + + G K ++ V+ + G+ D SV + Sbjct: 97 LVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 152 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFK 243 + + G + + H S F + +L +V+ S D W+ +GQ L Sbjct: 153 V--KTGKCLKTL--PAHSDPVSAVHFNR----DGSL-IVSSSYDGLCRIWDTASGQCL-- 201 Query: 244 ITQAEIKGLEAP 255 + I P Sbjct: 202 --KTLIDDDNPP 211 Score = 69.0 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 40/219 (18%), Positives = 88/219 (40%), Gaps = 17/219 (7%) Query: 30 DIEGENDDDDEMMNDDEEALEV-DMSNNS-LTYFDKHTDSVFAIGHHPNLPLVCTGGGDN 87 D+ +D + + D++ L++ D+S+ L H++ VF +P L+ +G D Sbjct: 87 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 146 Query: 88 LAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKL 147 +W + K TL + + V + F +G +V++ G + G + Sbjct: 147 SVRIW--DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG----QC 200 Query: 148 ASQMQEVEE--IVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCS 205 + + + + ++K P A D ++ + + G + +G +++ C Sbjct: 201 LKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLW-DYSK-GKCLKTYTGHKNEKYCI 257 Query: 206 MGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKI 244 F T +V+ S D+ + WN T + + K+ Sbjct: 258 FANFSVT----GGKWIVSGSEDNLVYIWNLQTKEIVQKL 292 >3MKQ-A nrPDB Length = 814 Score = 78.2 bits (191), Expect = 7e-15, Method: Composition-based stats. Identities = 52/245 (21%), Positives = 93/245 (37%), Gaps = 24/245 (9%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT-S 119 F+ H D + +I HP P V +G D LW + T G+ V+ +F Sbjct: 93 FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNW-ALEQTFEGHEHFVMCVAFNPK 151 Query: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG-S 178 + + + V V + + L + + + ++ +P + + A+D + Sbjct: 152 DPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQE--RGVNYVDYYPLPDKPYMITASDDLT 209 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 + + Q S + G H + S F T +++ S D T+ WN T Sbjct: 210 IKIW-DY-QTKSCVATLEG--HMSNVSFAVFHPT-----LPIIISGSEDGTLKIWNSST- 259 Query: 239 QQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLS 298 +K+ + GLE W ++ T G +A G +NG V++ N L L Sbjct: 260 ---YKVEKTLNVGLERSW-CIA----THPTGRKNYIASGFDNG-FTVLSLGNDEPTLSLD 310 Query: 299 TVIEL 303 V +L Sbjct: 311 PVGKL 315 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 38/191 (19%), Positives = 65/191 (34%), Gaps = 13/191 (6%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 F +D V I HP P V T +W +Q ++ V + F + Sbjct: 9 FSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVE--VRSIQVTETPVRAGKFIAR 66 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 +++ ++ V G K+ + I + HPT G+ D +V Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGE---KVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTVK 122 Query: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ 240 + E + +LEQ G H+ F D + LD T+ W+ Sbjct: 123 LWN-WENNWALEQTFEG--HEHFVMCVAFNPKDPST----FASGCLDRTVKVWSLGQSTP 175 Query: 241 LFKITQAEIKG 251 F +T + +G Sbjct: 176 NFTLTTGQERG 186 >2YNP-A nrPDB Length = 604 Score = 78.2 bits (191), Expect = 7e-15, Method: Composition-based stats. Identities = 52/245 (21%), Positives = 93/245 (37%), Gaps = 24/245 (9%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT-S 119 F+ H D + +I HP P V +G D LW + T G+ V+ +F Sbjct: 93 FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNW-ALEQTFEGHEHFVMCVAFNPK 151 Query: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG-S 178 + + + V V + + L + + + ++ +P + + A+D + Sbjct: 152 DPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQE--RGVNYVDYYPLPDKPYMITASDDLT 209 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 + + Q S + G H + S F T +++ S D T+ WN T Sbjct: 210 IKIW-DY-QTKSCVATLEG--HMSNVSFAVFHPT-----LPIIISGSEDGTLKIWNSST- 259 Query: 239 QQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLS 298 +K+ + GLE W ++ T G +A G +NG V++ N L L Sbjct: 260 ---YKVEKTLNVGLERSW-CIA----THPTGRKNYIASGFDNG-FTVLSLGNDEPTLSLD 310 Query: 299 TVIEL 303 V +L Sbjct: 311 PVGKL 315 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 39/191 (20%), Positives = 65/191 (34%), Gaps = 13/191 (6%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 F +D V I HP P V T LW +Q ++ V + F + Sbjct: 9 FSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVE--VRSIQVTETPVRAGKFIAR 66 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 +++ ++ V G K+ + I + HPT G+ D +V Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGE---KVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTVK 122 Query: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ 240 + E + +LEQ G H+ F D + LD T+ W+ Sbjct: 123 LWN-WENNWALEQTFEG--HEHFVMCVAFNPKDPST----FASGCLDRTVKVWSLGQSTP 175 Query: 241 LFKITQAEIKG 251 F +T + +G Sbjct: 176 NFTLTTGQERG 186 >5FL8-q nrPDB Length = 515 Score = 77.8 bits (190), Expect = 9e-15, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 80/213 (37%), Gaps = 27/213 (12%) Query: 33 GENDDDDE--MMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLP-LVCTGGGDNLA 89 G N +D+ ++ +V S + H ++ P+ + TG GDN A Sbjct: 109 GYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTA 168 Query: 90 HLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKG---GAQWK 146 +W +Q P TL G+ V+ S++ +G + T M + + + G G + Sbjct: 169 RIWDCDTQTP--MHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALR 226 Query: 147 LASQMQEVEEIVWLKTH---PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQD 203 S+ + + W H P A + DG++ + + + MSG + Sbjct: 227 GHSKW--ITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSR--VCQYTMSGHTNSVS 282 Query: 204 C--SMGEFINTDKGENTLELVTCSLDSTIVAWN 234 C G+ + L + S D T+ W+ Sbjct: 283 CVKWGGQGL----------LYSGSHDRTVRVWD 305 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 24/155 (15%), Positives = 58/155 (37%), Gaps = 14/155 (9%) Query: 79 LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMG 138 ++ T D LW K +TG+ + V +F+ +G ++V+A + + G Sbjct: 373 MMVTASDDYTMFLWNPLKST-KPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDG 431 Query: 139 QKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGF 198 + G + V ++ W + R + D ++ + + + S++ + G Sbjct: 432 RDGKFISTFRGHVASVYQVAW----SSDCRLLVSCSKDTTLKVWDVRTRKLSVD--LPG- 484 Query: 199 VHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAW 233 H+ + ++ K + + D + W Sbjct: 485 -HKDEVYTVDWSVDGK-----RVCSGGKDKMVRLW 513 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 36/179 (20%), Positives = 61/179 (34%), Gaps = 18/179 (10%) Query: 9 TTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMM---NDDEEALEVD--MSNNSLTYFDK 63 T EE +++ + E I +N + +EMM +DD + S + Sbjct: 348 TPEEAQKKALENYE-------KICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTG 400 Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H V + P+ + + DN LW KF T G+ SV +++S+ Sbjct: 401 HQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDG--KFISTFRGHVASVYQVAWSSDCRL 458 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 LV+ + V + L EV + W + G D V + Sbjct: 459 LVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDW----SVDGKRVCSGGKDKMVRLW 513 Score = 32.4 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 29/126 (23%), Positives = 49/126 (38%), Gaps = 20/126 (15%) Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDC--SMGEFINTDKGENTLEL 221 P + GA D + + + Q + + G + C + GE + Sbjct: 153 PHTSSRMVTGAGDNTARIWDCDTQ--TPMHTLKGHYNWVLCVSWSPD------GE---VI 201 Query: 222 VTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWI-SLSLAP-ETLTKGNSGVVACGSN 279 T S+D+TI W+ +GQ L + K WI SLS P + G+ +A S Sbjct: 202 ATGSMDNTIRLWDPKSGQCLGDALRGHSK-----WITSLSWEPIHLVKPGSKPRLASSSK 256 Query: 280 NGLLAV 285 +G + + Sbjct: 257 DGTIKI 262 Score = 32.4 bits (72), Expect = 0.42, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 16/30 (53%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWT 93 H D V+ + + VC+GG D + LWT Sbjct: 485 HKDEVYTVDWSVDGKRVCSGGKDKMVRLWT 514 >5MZH-A nrPDB Length = 452 Score = 74.4 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 38/179 (21%), Positives = 72/179 (40%), Gaps = 16/179 (8%) Query: 61 FDKHTDSVFAIGHH-PNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS 119 + H + V+AI + P + TG D LW +++ + TL G+ ++ SF Sbjct: 132 LEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTG--QLYYTLKGHQTEIVCLSFNP 189 Query: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 + + T M + + G + LA E+ + + T G+ D Sbjct: 190 QSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFN----TGGDLIVTGSFDHDS 245 Query: 180 WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 + + + G ++SG H+ + S +F TL +V+ S+D T W+ +G Sbjct: 246 RLWDV--RTGQCVHVLSG--HRGEVSSTQFNYA----GTL-VVSGSIDCTSRLWDVRSG 295 Score = 68.2 bits (165), Expect = 6e-12, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 66/192 (34%), Gaps = 15/192 (7%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H V + + LV +G D + LW S + G+ + V+ +F + G Sbjct: 262 HRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSG--RCLSVKQGHTDEVLDVAFDAAGTK 319 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 +V+A G ++ G Q L E+ ++ + +P R + D + + Sbjct: 320 MVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAF---NPQGTRLITASS-DKTCRLWD 375 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFK 243 G Q++ G H + F E ++T S D+T W T Sbjct: 376 C--DTGECLQVLEG--HTDEIFSCAFNY----EGDF-IITGSKDNTCRIWKALTASSQPA 426 Query: 244 ITQAEIKGLEAP 255 GL P Sbjct: 427 GPGGAGGGLARP 438 Score = 63.6 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 93/265 (35%), Gaps = 52/265 (19%) Query: 16 EIVPTVEVEQDVPVDIEGENDDDDEMMND--DEEALEVDMSNNSLTYFDK-HTDSVFAIG 72 E V T+E ++V I N D+++ D+ D L Y K H + + Sbjct: 127 EEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLS 186 Query: 73 HHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGK 132 +P ++ TG DN A LW + + TL G+ ++S F + G +VT Sbjct: 187 FNPQSTIIATGSMDNTAKLWDVETGQER--ATLAGHRAEIVSLGFNTGGDLIVTGSFDHD 244 Query: 133 VLVHM--------------GQKGGAQW------------KLASQMQEVEE---IVWLKTH 163 + G+ Q+ S++ +V + + H Sbjct: 245 SRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGH 304 Query: 164 PTIARTFAF---------GATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDK 214 AF + DGS Y + G + + G H+ + S F Sbjct: 305 TDEVLDVAFDAAGTKMVSASADGSARLY--HTLTGVCQHTLVG--HEGEISKVAFNP--- 357 Query: 215 GENTLELVTCSLDSTIVAWNCFTGQ 239 + T L+T S D T W+C TG+ Sbjct: 358 -QGT-RLITASSDKTCRLWDCDTGE 380 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 21/130 (16%), Positives = 43/130 (33%), Gaps = 6/130 (4%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 S L+ HTD V + + + D A L+ H+ TL G+ + Sbjct: 294 SGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLY--HTLTGVCQHTLVGHEGEIS 351 Query: 114 SCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFG 173 +F +G L+TA + G + ++ + ++ G Sbjct: 352 KVAFNPQGTRLITASSDKTCRLWDCDTG----ECLQVLEGHTDEIFSCAFNYEGDFIITG 407 Query: 174 ATDGSVWCYQ 183 + D + ++ Sbjct: 408 SKDNTCRIWK 417 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 52/235 (22%), Positives = 88/235 (37%), Gaps = 40/235 (17%) Query: 170 FAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINT--DKGENTLELVTCSLD 227 F G+ D + + G + G H+ F N DK +VT S D Sbjct: 109 FITGSYDRTCKVWNTFT--GEEVFTLEG--HKNVVYAIAFNNPYGDK------IVTGSFD 158 Query: 228 STIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVIN 287 T W+ +TGQ + +KG + + LS P+ S ++A GS + + + Sbjct: 159 KTCKLWDAYTGQLYYT-----LKGHQTEIVCLSFNPQ------STIIATGSMDNTAKLWD 207 Query: 288 CNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRH 347 G L+ A I S+ +++ L+ G + L+D + H Sbjct: 208 VETGQERATLAG----------HRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVH 257 Query: 348 KFVL-----EDSVTKLMFDNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLD 397 VL E S T+ + + + I+ ++ R+G+ V GH VLD Sbjct: 258 --VLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLD 310 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 67/333 (20%), Positives = 115/333 (34%), Gaps = 62/333 (18%) Query: 101 FAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWL 160 L + + +C+F G +T V G + L V I + Sbjct: 86 LFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFN 145 Query: 161 KTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLE 220 + G+ D + + G L + G HQ + F Sbjct: 146 NPY---GDKIVTGSFDKTCKLWDAYT--GQLYYTLKG--HQTEIVCLSFNPQSTI----- 193 Query: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNN 280 + T S+D+T W+ TGQ+ +A + G A +SL G + Sbjct: 194 IATGSMDNTAKLWDVETGQE-----RATLAGHRAEIVSL---------GFN-------TG 232 Query: 281 GLLAVINCNNGGAILHLSTVIELKPEQ--DELDASIESISWSSKFSLMAIGLVCGEILLY 338 G L V G+ H S + +++ Q L +S S++F+ +V G I Sbjct: 233 GDLIVT-----GSFDHDSRLWDVRTGQCVHVLSGHRGEVS-STQFNYAGTLVVSGSI--- 283 Query: 339 DTSA--WRVRHKFVLE------DSVTKLMFD--NDDLFASCINGKVYQFNARTGQEKFVC 388 D ++ W VR L D V + FD + ++ +G ++ TG + Sbjct: 284 DCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTL 343 Query: 389 VGHNMGVLDFILLHPVANTGTEQKRKVITAGDE 421 VGH G + + +P Q ++ITA + Sbjct: 344 VGHE-GEISKVAFNP-------QGTRLITASSD 368 >1VYH-C nrPDB Length = 410 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 44/243 (18%), Positives = 86/243 (35%), Gaps = 24/243 (9%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H V + HP ++ + D +W + F TL G+ +SV SF G Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG--DFERTLKGHTDSVQDISFDHSGKL 164 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 L + + + Q ++ M + V + + D ++ ++ Sbjct: 165 LASCSADMTIKLWDFQG----FECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWE 220 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFK 243 + Q G + +G H++ M + TL + +CS D T+ W T + + Sbjct: 221 V--QTGYCVKTFTG--HREWVRM----VRPNQDGTL-IASCSNDQTVRVWVVATKECKAE 271 Query: 244 ITQAEIKGLEAPW--------ISLSLAPETLTKGNSG-VVACGSNNGLLAVINCNNGGAI 294 + + W IS + ET G G + GS + + + + + G + Sbjct: 272 LREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCL 331 Query: 295 LHL 297 + L Sbjct: 332 MTL 334 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 34/106 (32%), Gaps = 6/106 (5%) Query: 78 PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHM 137 P + +G D +W TL G+ V F S G F+++ + V Sbjct: 309 PFLLSGSRDKTIKMW--DVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366 Query: 138 GQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 + + + E V A G+ D +V ++ Sbjct: 367 YKNK----RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 48/236 (20%), Positives = 82/236 (34%), Gaps = 36/236 (15%) Query: 98 PPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEI 157 P K+A L+G+ V F +V+A + V + G + L V++I Sbjct: 99 PEKYA--LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDI 156 Query: 158 VWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGEN 217 + + + A + D ++ + Q + M G H S+ N D Sbjct: 157 SFDHS----GKLLASCSADMTIKLWDF--QGFECIRTMHGHDHNVS-SVSIMPNGD---- 205 Query: 218 TLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACG 277 +V+ S D TI W TG + T W+ + + ++A Sbjct: 206 --HIVSASRDKTIKMWEVQTGYCVKTFTG------HREWVRM-----VRPNQDGTLIASC 252 Query: 278 SNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCG 333 SN+ + V + E K E E +E ISW+ + S +I G Sbjct: 253 SNDQTVRV----------WVVATKECKAELREHRHVVECISWAPESSYSSISEATG 298 Score = 49.3 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 30/197 (15%), Positives = 62/197 (31%), Gaps = 39/197 (19%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 F H + V + + + L+ + D +W ++ K L + V S+ E Sbjct: 230 FTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECK--AELREHRHVVECISWAPE 287 Query: 121 --------------------GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWL 160 G FL++ + + G M V W+ Sbjct: 288 SSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG------MCLMTLVGHDNWV 341 Query: 161 KT--HPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENT 218 + + + A D ++ + + + ++ H+ + +F T Sbjct: 342 RGVLFHSGGKFILSCADDKTLRVW-DYKNK-RCMKTLNA--HEHFVTSLDFHKTAP---- 393 Query: 219 LELVTCSLDSTIVAWNC 235 +VT S+D T+ W C Sbjct: 394 -YVVTGSVDQTVKVWEC 409 >5NNZ-B nrPDB Length = 415 Score = 68.6 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 44/214 (20%), Positives = 69/214 (32%), Gaps = 43/214 (20%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 F HT + + +P LV TG D A LW + + TL G+ +IS SF + Sbjct: 173 FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY--TLRGHSAEIISLSFNTS 230 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 G ++T V+V G L E+ + G+ D + Sbjct: 231 GDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNW----DCSLILTGSMDKTCK 286 Query: 181 CYQINEQDGSLEQLMSGFVHQ--QDC--SMGEFINTDKGENTLE---------------- 220 + + +G ++G + C G+ I T + T Sbjct: 287 LW--DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGH 344 Query: 221 ---------------LVTCSLDSTIVAWNCFTGQ 239 L+T S D T W+ TGQ Sbjct: 345 EGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378 Score = 64.4 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 43/198 (21%), Positives = 76/198 (38%), Gaps = 16/198 (8%) Query: 54 SNNSLTYFDKHTDSVFAIGHH-PNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESV 112 S L + H + V+AI + P + TG D LW+ + K T G+ + Sbjct: 123 SGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG--KCYHTFRGHTAEI 180 Query: 113 ISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAF 172 + SF + + T M + Q G + L E I+ L + + R Sbjct: 181 VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAE---IISLSFNTSGDRII-T 236 Query: 173 GATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVA 232 G+ D +V + + G ++ G H + S F N D ++T S+D T Sbjct: 237 GSFDHTVVVW--DADTGRKVNILIG--HCAEISSASF-NWDCS----LILTGSMDKTCKL 287 Query: 233 WNCFTGQQLFKITQAEIK 250 W+ G+ + +T + + Sbjct: 288 WDATNGKCVATLTGHDDE 305 Score = 52.4 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 18/120 (15%), Positives = 41/120 (34%), Gaps = 6/120 (5%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H D + L+ T D A ++++ ++ K L G+ + SF +G Sbjct: 302 HDDEILDSCFDYTGKLIATASADGTARIFSAATR--KCIAKLEGHEGEISKISFNPQGNH 359 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 L+T + Q G + ++ + ++ G+ D + ++ Sbjct: 360 LLTGSSDKTARIWDAQTG----QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 30.1 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 18/39 (46%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW 92 + L + HTD +F+ + +V TG DN +W Sbjct: 376 TGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 >6QX9-5O nrPDB Length = 357 Score = 64.7 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 34/171 (19%), Positives = 65/171 (38%), Gaps = 14/171 (8%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H V+ HPN + + G D L LW + + TL G+ +V+ + ++G Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNY-ATLKGHSGAVMELHYNTDGSM 123 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 L +A V V + G +L V + P + G+ DG+V + Sbjct: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP---QLVCTGSDDGTVKLWD 180 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 I ++ + F + F +T ++++ +D+ I W+ Sbjct: 181 IRKK-----AAIQTFQNTYQVLAVTFNDTSD-----QIISGGIDNDIKVWD 221 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 30/149 (20%), Positives = 57/149 (38%), Gaps = 12/149 (8%) Query: 35 NDDDDEMMND--DEEALEVDMSNNSLTYFDK-HTDSVFAIGHHPNLPLVCTGGGDNLAHL 91 ND D++++ D + D+ N LTY + H DSV + + + DN + Sbjct: 202 NDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRV 261 Query: 92 WTSHSQPPK------FAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQW 145 W PK F G + + ++++ CS++ +G + V V + Sbjct: 262 WDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILY 321 Query: 146 KLASQMQEVEEIVWLKTHPTIARTFAFGA 174 KL + E+ + HP + + Sbjct: 322 KLPGHAGSINEVAF---HPDEPIIISASS 347 Score = 51.7 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 27/124 (21%), Positives = 50/124 (40%), Gaps = 6/124 (4%) Query: 63 KHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGG 122 ++T V A+ + + +GG DN +W K T+ G+ +SV S +SEG Sbjct: 191 QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN--KLTYTMRGHADSVTGLSLSSEGS 248 Query: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQ----EVEEIVWLKTHPTIARTFAFGATDGS 178 +L++ M V V + + + Q E+ + + A G+ D Sbjct: 249 YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRF 308 Query: 179 VWCY 182 V+ + Sbjct: 309 VYVW 312 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 28/172 (16%), Positives = 56/172 (32%), Gaps = 26/172 (15%) Query: 76 NLPLVCTGGGDNLAHLWTS-----HSQPPKFAGT------LTGYGESVISCSFTSEGGFL 124 + L+ G G + + PP+ + L+G+ V C F G L Sbjct: 22 HELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTL 81 Query: 125 VTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQI 184 +A +L+ + + ++ V + T +TD +V + Sbjct: 82 ASAGFDRLILLWNVYGDCDNY---ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVW-- 136 Query: 185 NEQDGSLEQLMSGFVHQQDCSMGEFINT--DKGENTLELVTCSLDSTIVAWN 234 + + G + + G F+N+ + T S D T+ W+ Sbjct: 137 DSETGERVKRLKGH--------TSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 11/75 (14%), Positives = 30/75 (40%), Gaps = 2/75 (2%) Query: 65 TDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFL 124 ++ P+ + G D ++W + S+ + L G+ S+ +F + + Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSR--RILYKLPGHAGSINEVAFHPDEPII 342 Query: 125 VTADMSGKVLVHMGQ 139 ++A ++ + Q Sbjct: 343 ISASSDKRLYMGEIQ 357 Score = 34.3 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 20/89 (22%), Positives = 34/89 (38%), Gaps = 9/89 (10%) Query: 156 EIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKG 215 E+ K HP T A D + + + G + + H M NTD Sbjct: 68 EVYCCKFHPN-GSTLASAGFDRLILLWNVY---GDCDNYATLKGHSGAV-MELHYNTDGS 122 Query: 216 ENTLELVTCSLDSTIVAWNCFTGQQLFKI 244 L + S D T+ W+ TG+++ ++ Sbjct: 123 ----MLFSASTDKTVAVWDSETGERVKRL 147 >6QX9-4B nrPDB Length = 522 Score = 64.7 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 32/170 (18%), Positives = 59/170 (34%), Gaps = 14/170 (8%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H+ V+ I H + L TGG D +W + + L G+ + + +F+ G Sbjct: 364 HSMGVYDIAFHQDGSLAGTGGLDAFGRVW--DLRTGRCIMFLEGHLKEIYGINFSPNGYH 421 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 + T V ++ + + + V + K P GA D + + Sbjct: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGV---KFEPIHGNFLLTGAYDNTAKIWT 478 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAW 233 S + ++G H+ + D + + TCS D T W Sbjct: 479 --HPGWSPLKTLAG--HEGKV-----MGLDISSDGQLIATCSYDRTFKLW 519 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 19/77 (24%), Positives = 31/77 (40%), Gaps = 3/77 (3%) Query: 64 HTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGG 122 H + V + P + + TG DN A +WT P TL G+ V+ +S+G Sbjct: 448 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSP--LKTLAGHEGKVMGLDISSDGQ 505 Query: 123 FLVTADMSGKVLVHMGQ 139 + T + M + Sbjct: 506 LIATCSYDRTFKLWMAE 522 Score = 51.3 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 26/128 (20%), Positives = 46/128 (35%), Gaps = 11/128 (8%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 + + + H ++ I PN + TG GDN +W + + T+ + V F Sbjct: 400 IMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQR--RCVYTIPAHQNLVTGVKF 457 Query: 118 TS-EGGFLVTA--DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGA 174 G FL+T D + K+ H G W + E V + + A + Sbjct: 458 EPIHGNFLLTGAYDNTAKIWTHPG------WSPLKTLAGHEGKVMGLDISSDGQLIATCS 511 Query: 175 TDGSVWCY 182 D + + Sbjct: 512 YDRTFKLW 519 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 35/187 (18%), Positives = 58/187 (31%), Gaps = 23/187 (12%) Query: 56 NSLTYFDKHTDSVFAIGHHPNLPL--------VCTGGGDNLAHLWTSHSQPPKFAGTLTG 107 N L H +V AI HP + + + D LW+ S P + G Sbjct: 264 NLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEP--VADIEG 321 Query: 108 YGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIA 167 + V + G FL T + + AQ ++ Q + + H Sbjct: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE---AQEEILHQEGHSMGVYDIAFH-QDG 377 Query: 168 RTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLD 227 G D + + + G + G H ++ F N + T S D Sbjct: 378 SLAGTGGLDAFGRVWDL--RTGRCIMFLEG--HLKEIYGINF-----SPNGYHIATGSGD 428 Query: 228 STIVAWN 234 +T W+ Sbjct: 429 NTCKVWD 435 >5NZU-C nrPDB Length = 905 Score = 62.4 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 47/226 (20%), Positives = 80/226 (35%), Gaps = 24/226 (10%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT-S 119 F+ H+D + I HP P + T D L LW + + G+ V+ Sbjct: 95 FEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKW-SCSQVFEGHTHYVMQIVINPK 153 Query: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 + +A + + V + L + V I + GA D V Sbjct: 154 DNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSG--GDKPYLISGADDRLV 211 Query: 180 WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQ 239 + Q+ + Q + G H Q+ S F ++T S D T+ W+ T Sbjct: 212 KIW-DY-QNKTCVQTLEG--HAQNVSCASFHPE-----LPIIITGSEDGTVRIWHSST-- 260 Query: 240 QLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAV 285 +++ G+E W SL +G++ VA G + G + V Sbjct: 261 --YRLESTLNYGMERVWCVASL------RGSNN-VALGYDEGSIIV 297 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 33/172 (19%), Positives = 60/172 (34%), Gaps = 17/172 (9%) Query: 65 TDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFL 124 +D V ++ HP P + + +W +Q T V + F + ++ Sbjct: 15 SDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQT--LVKTFEVCDLPVRAAKFVARKNWV 72 Query: 125 VTA--DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 VT DM +V + + ++ S + I + HPT D + + Sbjct: 73 VTGADDMQIRVFNYNTLERVHMFEAHS-----DYIRCIAVHPTQPFILTSSD-DMLIKLW 126 Query: 183 QINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 ++ S Q+ G H + + + K N + SLD TI W Sbjct: 127 -DWDKKWSCSQVFEGHTH----YVMQIVINPKDNNQF--ASASLDRTIKVWQ 171 >4YCZ-A nrPDB Length = 876 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 47/263 (17%), Positives = 92/263 (34%), Gaps = 29/263 (11%) Query: 80 VCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE--GGFLVTADMSGKVLVHM 137 + T D ++ + + TL G+ +V S+ G L +A GKVL+ Sbjct: 33 LATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWR 92 Query: 138 GQKGGAQ--WKLASQMQEVEEIVWLKTHPTIAR-TFAFGATDGSVWCYQINEQDGSLEQL 194 G Q + A V + W P A A ++DG+V + + Sbjct: 93 ELNGAWQRIFDFALHKASVNVVSWS---PHEAGCLLACASSDGNVSVLEFRDNSWEHSIF 149 Query: 195 ------MSGFVHQQDCSMGEFINTD---KGENTLELVTCSLDSTIVAWNCFTGQQLFKIT 245 ++ S G +++ K VT D+ + W +K+ Sbjct: 150 HAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLE 209 Query: 246 QAEIKGLEAPWI-SLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELK 304 + + G W+ ++ +P L K +A S + + + + + V+ Sbjct: 210 REPLTG-HTDWVRDVAWSPTVLQKSY---IASASEDRTVRIWTSDPANPLQWNCKVL--- 262 Query: 305 PEQDELDASIESISWSSKFSLMA 327 DA++ +SWS +++A Sbjct: 263 ----NFDAAVWRVSWSLSGNVLA 281 Score = 41.6 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 23/205 (11%), Positives = 49/205 (23%), Gaps = 72/205 (35%) Query: 61 FDKHTDSVFAIGHHPNLP--LVCTGGGDNLAHL------------------------WTS 94 F H SV + P+ L+ D + W Sbjct: 104 FALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAP 163 Query: 95 HSQPPKFAGT---------------------------------------LTGYGESVISC 115 + P + LTG+ + V Sbjct: 164 ATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDV 223 Query: 116 SFTS---EGGFLVTADMSGKVLVHMGQKGGA-QWKLASQMQEVEEIVWLKTHPTIARTFA 171 +++ + ++ +A V + QW ++ + VW + A Sbjct: 224 AWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNC--KVLNFDAAVWRVSWSLSGNVLA 281 Query: 172 FGATDGSVWCYQIN-EQDGSLEQLM 195 D V ++ N + + + + Sbjct: 282 ASGGDNKVTLWKENLKGEWECVKTI 306 >4AEZ-A nrPDB Length = 401 Score = 61.7 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 38/199 (19%), Positives = 74/199 (37%), Gaps = 19/199 (9%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYG 109 +V ++N+ + H+ V + + + +GG DN+ +W + S PKF T T + Sbjct: 202 DVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKF--TKTNHN 259 Query: 110 ESVISCSFTS-EGGFLVT--ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTI 166 +V + ++ + L T M ++ GA+ +V ++W I Sbjct: 260 AAVKAVAWCPWQSNLLATGGGTMDKQIHFWNA-ATGARVNTVDAGSQVTSLIWSPHSKEI 318 Query: 167 ARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGE--FINTDKGENTLELVTC 224 T F + S+W Y SG Q D + + + + L T Sbjct: 319 MSTHGFPDNNLSIWSYSS-----------SGLTKQVDIPAHDTRVLYSALSPDGRILSTA 367 Query: 225 SLDSTIVAWNCFTGQQLFK 243 + D + W + G + + Sbjct: 368 ASDENLKFWRVYDGDHVKR 386 Score = 44.7 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 22/133 (16%), Positives = 43/133 (32%), Gaps = 12/133 (9%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQ--PPKFAGTLTGYGES 111 S L H V + + + ++ +G H H GTL G+ Sbjct: 165 SQTKLRTMAGHQARVGCLSWNRH--VLSSGSRSGAIH---HHDVRIANHQIGTLQGHSSE 219 Query: 112 VISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFA 171 V ++ S+G L + V + + ++ + V+ + W P + A Sbjct: 220 VCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWC---PWQSNLLA 276 Query: 172 F--GATDGSVWCY 182 G D + + Sbjct: 277 TGGGTMDKQIHFW 289 >5GAN-H nrPDB Length = 465 Score = 61.7 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 37/183 (20%), Positives = 71/183 (38%), Gaps = 15/183 (8%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 ++ L + H VF++ + LVC+GG D+L+ LW S TL G+ + + Sbjct: 296 THQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVM--TLAGHSKPIY 353 Query: 114 SCSFTSEGGFLVTADMSGKVLVHMGQK--GGAQWKLASQMQEVEEIVWLKTHPTIARTFA 171 + +++ G + T G + V +K G ++ + V ++ + K + Sbjct: 354 TVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDG--GKKLV 411 Query: 172 FGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIV 231 D + Y ++G + I+ D N+ LV+ D +I Sbjct: 412 SCGYDNLINVYS--SDTWLKMGSLAGHTDK-------IISLDISNNSHFLVSGGWDRSIK 462 Query: 232 AWN 234 WN Sbjct: 463 LWN 465 Score = 35.9 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 99/257 (38%), Gaps = 33/257 (12%) Query: 112 VISCSFTSEGGFLVTADMSGKVLVHMGQK-GGAQWKLASQMQEVEEIVWLKTHPTIARTF 170 + + S +++ + T +G + V Q KL S + ++ I W HP Sbjct: 178 ISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDW---HPDSNNQM 234 Query: 171 AFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTI 230 A DG + +Q + ++G L L H++ S ++ + K + S D T Sbjct: 235 ISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIG-----SASHDMTW 289 Query: 231 VAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNN 290 W+ T Q+L +G + SLS + +V G + L + + + Sbjct: 290 RLWDASTHQELLL-----QEGHDKGVFSLSFQCD------GSLVCSGGMDSLSMLWDIRS 338 Query: 291 GGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDT---SAWRVRH 347 G ++ L+ KP I +++WS +A G G I ++D ++ Sbjct: 339 GSKVMTLAG--HSKP--------IYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQ 388 Query: 348 KFVLEDSVTKLMFDNDD 364 + VT++ F +D Sbjct: 389 ILAHRNIVTQVRFSKED 405 >6HQA-B nrPDB Length = 722 Score = 61.3 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 45/296 (15%), Positives = 100/296 (33%), Gaps = 54/296 (18%) Query: 27 VPVDIEGEND--DDDEMMNDDEEALEVDMSNNSLT-----YFDKHTDSVFAIGHHPNLPL 79 +P+ ++ D +D M+ D +++ + SL F + + + + + + Sbjct: 345 LPLPLKSAQDLRNDIAMIQDSRAKIKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTM 404 Query: 80 VCTGGGDNLAHLWTSHSQPPKFA-------------------GTLTGYGESVISCSFTSE 120 V +G D+ LW+ P + L G+ +V F+ + Sbjct: 405 VASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPD 464 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 +L++ V + + + VW + FA + D + Sbjct: 465 NRYLISCSEDKTVRLWSLDT----YTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTAR 520 Query: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQ- 239 + ++ +G ++ DC EF N+ L T S D T W+ G+ Sbjct: 521 LWSC--DHIYPLRIFAGHLNDVDCV--EFHP-----NSTYLFTGSSDKTARMWDIARGEC 571 Query: 240 -QLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAI 294 ++F I L+++P+ +A + ++ + + + G I Sbjct: 572 VRVFMGHSGAIN-------CLAVSPD------GRWLASAGEDSVVCLWDISTGRRI 614 Score = 42.0 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 36/82 (43%), Gaps = 3/82 (3%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYG-ESVISCSFTS 119 F H+ ++ + P+ + + G D++ LW + + G+G S+ S +F+ Sbjct: 575 FMGHSGAINCLAVSPDGRWLASAGEDSVVCLW--DISTGRRIKAMRGHGRSSIYSLAFSR 632 Query: 120 EGGFLVTADMSGKVLVHMGQKG 141 EG LV+ V V +K Sbjct: 633 EGTVLVSTGADNSVRVWDVKKN 654 >6ID0-T nrPDB Length = 514 Score = 60.9 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 41/197 (20%), Positives = 80/197 (40%), Gaps = 17/197 (8%) Query: 55 NNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVIS 114 N + ++ H +V+ + HP + ++ T D+ A +W ++ TL+G+ +V + Sbjct: 278 NKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKAS--VHTLSGHTNAVAT 335 Query: 115 CSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGA 174 + ++T + + G + L + + V +V H TFA G+ Sbjct: 336 VRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRH----YTFASGS 391 Query: 175 TDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 D + ++ DGS Q +SG INT + LV+ + + T+ W+ Sbjct: 392 PDN-IKQWKF--PDGSFIQNLSGH--------NAIINTLTVNSDGVLVSGADNGTMHLWD 440 Query: 235 CFTGQQLFKITQAEIKG 251 TG ++ A G Sbjct: 441 WRTGYNFQRVHAAVQPG 457 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 33/184 (17%), Positives = 62/184 (33%), Gaps = 17/184 (9%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H V I P TG D +W K +LTG+ +V ++ + Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIW--DLASGKLKLSLTGHISTVRGVIVSTRSPY 260 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQ-EVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 L + +V + K+ + + L HPTI + D + + Sbjct: 261 LFSCGEDKQVKCWDLEYN----KVIRHYHGHLSAVYGLDLHPTI-DVLVTCSRDSTARIW 315 Query: 183 QINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLF 242 + + + +SG H + + +++T S D+TI W+ G+ Sbjct: 316 DVRTK--ASVHTLSG--HTNAVATVRCQAAEP-----QIITGSHDTTIRLWDLVAGKTRV 366 Query: 243 KITQ 246 +T Sbjct: 367 TLTN 370 Score = 37.8 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 47/141 (33%), Gaps = 15/141 (10%) Query: 98 PPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEI 157 P K ++G+ V + + VT + + G + L + V + Sbjct: 193 PWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV 252 Query: 158 VWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGF-VHQQDCSMGEFINTDKGE 216 + P F+ G D V C+ D +++ + H + T Sbjct: 253 IVSTRSP---YLFSCGE-DKQVKCW-----DLEYNKVIRHYHGHLSAVYGLDLHPT---- 299 Query: 217 NTLELVTCSLDSTIVAWNCFT 237 LVTCS DST W+ T Sbjct: 300 -IDVLVTCSRDSTARIWDVRT 319 >4L9O-A nrPDB Length = 349 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 26/139 (18%), Positives = 44/139 (31%), Gaps = 12/139 (8%) Query: 64 HTDSVFAIGHHP-----NLPLVCTGGGDNLAHLWTSHSQPPKFAG--TLTGYGESVISCS 116 H V A P N +GG DNL +W F G+ + V + Sbjct: 204 HAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVA 263 Query: 117 FTSE---GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQE-VEEIVWLKTHPTIARTFAF 172 ++ ++ TA VL+ +W+ +E ++ W + A Sbjct: 264 WSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAI 323 Query: 173 GATDGSVWCYQINEQ-DGS 190 D V ++ N Q Sbjct: 324 SGGDNKVTLWKENIQGKWE 342 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 70/208 (33%), Gaps = 18/208 (8%) Query: 80 VCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE--GGFLVTADMSGKVLVHM 137 + T D ++ + + TL G+ V ++ G L + GKVL+ Sbjct: 84 LATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK 143 Query: 138 GQKG--GAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLM 195 G + + V + W A DG + + + G+LE ++ Sbjct: 144 EDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASS--DGKISIVE-FKDGGALEPIV 200 Query: 196 SGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLE-- 253 H + + +NT V+ D+ + W T E + + Sbjct: 201 I-QGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRY----DDAAKTFIEEEAFQGH 255 Query: 254 APWI-SLSLAPETLTKGNSGVVACGSNN 280 + W+ ++ +P L+K +A S + Sbjct: 256 SDWVRDVAWSPSRLSKSY---IATASQD 280 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 40/203 (19%), Positives = 69/203 (33%), Gaps = 21/203 (10%) Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVW--LKTHPTIARTFAFGATDGS 178 G L T + + G +L + E VW HP A + DG Sbjct: 81 GRRLATCSSDKTIKIFEID--GENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGK 138 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDS-TIVAWNCFT 237 V ++ E +G ++ VHQ + + + G + L S +IV + Sbjct: 139 VLIWK--EDNGVWNKVAEHSVHQASVNSVSWAPHEYGP--VLLCASSDGKISIVEFKDGG 194 Query: 238 GQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHL 297 + I I A W +SL P+ + G + L+ + ++ Sbjct: 195 ALEPIVIQGHAIGVNAASWAPISL-PDNTRR-----FVSGGCDNLVKIWRYDDAA----- 243 Query: 298 STVIELKPEQDELDASIESISWS 320 T IE + Q D + ++WS Sbjct: 244 KTFIEEEAFQGHSDW-VRDVAWS 265 >4V7E-Bg nrPDB Length = 380 Score = 60.1 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 52/278 (18%), Positives = 98/278 (35%), Gaps = 34/278 (12%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPK-----FAGTLTGYGESVISCSFT 118 H V PN V GG D+ ++ SQ + + LTG+ SC + Sbjct: 107 HCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYV 166 Query: 119 SEG-GFLVTADMSGKVLVHMGQKG------GAQWKLASQMQEVEEIVWLKTHPTIARTFA 171 + L+T ++ G G+++ +++ L + A F Sbjct: 167 PDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSG----HTADVLSLSINSLNANMFI 222 Query: 172 FGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIV 231 G+ D +V + + + + + H+ D + +F + T S D T Sbjct: 223 SGSCDTTVRLW---DLRITSRAVRTYHGHEGDINSVKFFPDGQ-----RFGTGSDDGTCR 274 Query: 232 AWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNG 291 ++ TG QL + + I S+A + ++ G +NG V + Sbjct: 275 LFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGR----LLFAGYSNGDCYVWDTLLA 330 Query: 292 GAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIG 329 +L+L T+ Q+ + I + SS S + G Sbjct: 331 EMVLNLGTL------QNSHEGRISCLGLSSDGSALCTG 362 Score = 52.0 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 36/163 (22%), Positives = 71/163 (43%), Gaps = 15/163 (9%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 TL G+ V S +T E ++V+A G+++V + V E + Sbjct: 61 TLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPN- 119 Query: 164 PTIARTFAFGATDGSVWCYQIN---EQDGSL--EQLMSGFVHQQDCSMGEFINTDKGENT 218 ++ A G D + + ++ ++DG++ ++++G H+ S +++ + Sbjct: 120 ---GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTG--HKGYASSCQYVPDQET--- 171 Query: 219 LELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSL 261 L+T S D T V W+ TGQ++ G A +SLS+ Sbjct: 172 -RLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSI 213 >5Z56-q nrPDB Length = 504 Score = 60.1 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 35/192 (18%), Positives = 65/192 (33%), Gaps = 35/192 (18%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 S L HT V ++ HP+ LV + D +W+ + + + +V Sbjct: 253 SEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS--CVQVVRAHESAVT 310 Query: 114 SCSFTSEGGFLVTADMS----------GKVLVHMGQK-GGAQWKLASQMQEVEEIVWLKT 162 S + G +L+++ G+VL + + G A + Sbjct: 311 GLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA------------QF 358 Query: 163 HPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELV 222 HP F G D + + + E+ + + H + F EN L Sbjct: 359 HP-DGLIFGTGTMDSQIKIWDLKER----TNVANFPGHSGPITSIAF-----SENGYYLA 408 Query: 223 TCSLDSTIVAWN 234 T + DS++ W+ Sbjct: 409 TAADDSSVKLWD 420 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 45/115 (39%), Gaps = 15/115 (13%) Query: 74 HPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKV 133 HP+ + TG D+ +W + G+ + S +F+ G +L TA V Sbjct: 359 HPDGLIFGTGTMDSQIKIWDLKERTN--VANFPGHSGPITSIAFSENGYYLATAADDSSV 416 Query: 134 LVHMGQKGGAQWKLASQMQ-----EVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 + +K K +Q EV+ +++ ++ A G TD ++ + Sbjct: 417 KLWDLRK----LKNFKTLQLDNNFEVKSLIFDQS----GTYLALGGTDVQIYICK 463 >4LG8-A nrPDB Length = 354 Score = 60.1 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 35/192 (18%), Positives = 65/192 (33%), Gaps = 35/192 (18%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 S L HT V ++ HP+ LV + D +W+ + + + +V Sbjct: 103 SEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNAS--CVQVVRAHESAVT 160 Query: 114 SCSFTSEGGFLVTADMS----------GKVLVHMGQK-GGAQWKLASQMQEVEEIVWLKT 162 S + G +L+++ G+VL + + G A + Sbjct: 161 GLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA------------QF 208 Query: 163 HPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELV 222 HP F G D + + + E+ + + H + F EN L Sbjct: 209 HP-DGLIFGTGTMDSQIKIWDLKER----TNVANFPGHSGPITSIAF-----SENGYYLA 258 Query: 223 TCSLDSTIVAWN 234 T + DS++ W+ Sbjct: 259 TAADDSSVKLWD 270 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 45/115 (39%), Gaps = 15/115 (13%) Query: 74 HPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKV 133 HP+ + TG D+ +W + G+ + S +F+ G +L TA V Sbjct: 209 HPDGLIFGTGTMDSQIKIWDLKERTN--VANFPGHSGPITSIAFSENGYYLATAADDSSV 266 Query: 134 LVHMGQKGGAQWKLASQMQ-----EVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 + +K K +Q EV+ +++ ++ A G TD ++ + Sbjct: 267 KLWDLRK----LKNFKTLQLDNNFEVKSLIFDQS----GTYLALGGTDVQIYICK 313 >6MZM-G nrPDB Length = 800 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 30/125 (24%), Positives = 45/125 (36%), Gaps = 6/125 (4%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 L F H V HPN V TG D LW + TG+ + S +F Sbjct: 620 LRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG--NCVRIFTGHKGPIHSLTF 677 Query: 118 TSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG 177 + G FL T G+VL+ G + +++ + V A G+ D Sbjct: 678 SPNGRFLATGATDGRVLLWDIGHG----LMVGELKGHTDTVCSLRFSRDGEILASGSMDN 733 Query: 178 SVWCY 182 +V + Sbjct: 734 TVRLW 738 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 36/177 (20%), Positives = 56/177 (31%), Gaps = 15/177 (8%) Query: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 L + H V+ P +GG D +A LW + P G+ V F Sbjct: 578 LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQP--LRIFAGHLADVNCTRF 635 Query: 118 TSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG 177 ++ T V + G + + T R A GATDG Sbjct: 636 HPNSNYVATGSADRTVRLWDVLNG----NCVRIFTGHKGPIHSLTFSPNGRFLATGATDG 691 Query: 178 SVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 V + I G + + G H F + L + S+D+T+ W+ Sbjct: 692 RVLLWDIGH--GLMVGELKG--HTDTVCSLRFSRDGEI-----LASGSMDNTVRLWD 739 Score = 51.3 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 47/236 (19%), Positives = 86/236 (36%), Gaps = 34/236 (14%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 L G+ V SF+ + +L+++ G V + Q + + VW Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT----FTCLVGYKGHNYPVWDTQF 593 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 F G D + ++ +G H D + F N+ + T Sbjct: 594 SPYGYYFVSGGHDRVARLWAT--DHYQPLRIFAG--HLADVNCTRFHP-----NSNYVAT 644 Query: 224 CSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLL 283 S D T+ W+ G + T G + P SL+ +P N +A G+ +G + Sbjct: 645 GSADRTVRLWDVLNGNCVRIFT-----GHKGPIHSLTFSP------NGRFLATGATDGRV 693 Query: 284 AVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYD 339 + + +G V ELK D ++ S+ +S ++A G + + L+D Sbjct: 694 LLWDIGHG------LMVGELKGHTD----TVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 21/94 (22%), Positives = 36/94 (38%), Gaps = 2/94 (2%) Query: 53 MSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESV 112 ++ N + F H + ++ PN + TG D LW G L G+ ++V Sbjct: 657 LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW--DIGHGLMVGELKGHTDTV 714 Query: 113 ISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWK 146 S F+ +G L + M V + K + Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLE 748 >3JRO-A nrPDB Length = 753 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 35/194 (18%), Positives = 63/194 (32%), Gaps = 33/194 (17%) Query: 62 DKHTDSVFAIGHHPNL-------------PLVCTGGGDNLAHLWTSHSQPPKFA--GTLT 106 D H V + P TGG DNL +W +S + TL Sbjct: 142 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLE 201 Query: 107 GYGESVISCSFTSE---GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVE--EIVWLK 161 G+ + V +++ +L + ++ WK + ++E + +++W Sbjct: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK-KTLLKEEKFPDVLWRA 260 Query: 162 THPTIARTFAFGATDGSVWCYQIN-EQDGSLEQLMSGFVHQ-------QDCSMGEFINTD 213 + A D V ++ N E +G VHQ + EF Sbjct: 261 SWSLSGNVLALSGGDNKVTLWKENLEGKWE----PAGEVHQGGGGSGGGGATSKEFDGPC 316 Query: 214 KGENTLELVTCSLD 227 + E L C+ + Sbjct: 317 QNEIDLLFSECNDE 330 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 34/212 (16%), Positives = 68/212 (32%), Gaps = 18/212 (8%) Query: 80 VCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE--GGFLVTADMSGKVLVHM 137 + T D ++ + K TLTG+ V + G L + GKVL+ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 138 GQKGGAQWKLASQ----MQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQ 193 + G +W + V + W A SV ++ N + Sbjct: 84 EENG--RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII 141 Query: 194 LMSGFVHQQDCSMGEFINTD----KGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEI 249 I D + + + VT D+ + W + + ++ + Sbjct: 142 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK-YNSDAQTYVLESTL 200 Query: 250 KGLEAPWI-SLSLAPETLTKGNSGVVACGSNN 280 +G + W+ ++ +P L + +A S + Sbjct: 201 EG-HSDWVRDVAWSPTVLLRSY---LASVSQD 228 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 38/207 (18%), Positives = 62/207 (29%), Gaps = 11/207 (5%) Query: 101 FAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWL 160 + E + G L T + + + G KL + E VW Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWR 58 Query: 161 K--THPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENT 218 HP A + DG V ++ S + + VH + ++ + G Sbjct: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHA--VHSASVNSVQWAPHEYGP-- 114 Query: 219 LELVTCSLDSTIVAWNCFTGQQLFKITQAEIKG-LEAPWISLSLAPETLTKGN--SGVVA 275 L LV S V G I A G A W ++ + G S Sbjct: 115 LLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 174 Query: 276 CGSNNGLLAVINCNNGGAILHLSTVIE 302 G + L+ + N+ L + +E Sbjct: 175 TGGADNLVKIWKYNSDAQTYVLESTLE 201 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 41/250 (16%), Positives = 74/250 (29%), Gaps = 54/250 (21%) Query: 64 HTDSVFAIGH-HPNL-PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE- 120 H V+ + HP ++ + D +W + + SV S + Sbjct: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHE 111 Query: 121 -GGFLVTADMSGKVLVHMGQKGG----------------AQWKLASQMQEVEEIVWLKTH 163 G L+ A GKV V ++ G A W A+ ++ E Sbjct: 112 YGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEH-----NG 166 Query: 164 PTIARTFAFGATDGSVWCYQINEQ--DGSLEQLMSGFVHQQDCSMGEFINTDKGENTLEL 221 +R F G D V ++ N LE + G + + + L Sbjct: 167 TKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSD----WVRDVAWSPTVLLRSYL 222 Query: 222 VTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPW----ISLSLAPETLTKGN-----SG 272 + S D T + W + PW + P+ L + + + Sbjct: 223 ASVSQDRTCIIW--------------TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNV 268 Query: 273 VVACGSNNGL 282 + G +N + Sbjct: 269 LALSGGDNKV 278 >6BX3-A nrPDB Length = 314 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 37/199 (18%), Positives = 64/199 (32%), Gaps = 27/199 (13%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYG 109 +++ S T H + P+ + T D + T G+ Sbjct: 39 DINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEII---HLSYGLLHTFIGHT 95 Query: 110 ESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIART 169 VIS +F +G L T+ M + + G+ K S E +V + + Sbjct: 96 APVISLTFNRKGNLLFTSSMDESIKIWDT-LNGSLMKTISAHSEA--VVSVDVPMNDSSI 152 Query: 170 FAFGATDGSVWCYQ----------INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTL 219 + G+ DG + + ++D E +G V EN Sbjct: 153 LSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE---NGVVPISQVKFS--------ENAR 201 Query: 220 ELVTCSLDSTIVAWNCFTG 238 L+ SLD + W+C G Sbjct: 202 YLLVKSLDGVVKIWDCIGG 220 >5WYJ-BC nrPDB Length = 817 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 71/200 (35%), Gaps = 16/200 (8%) Query: 36 DDDDEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSH 95 D ++ N + LE ++N H ++ + L+ T GD +W+ Sbjct: 512 DKTCKIWNLENGELEATLAN--------HKRGLWDVSFCQYDKLLATSSGDKTVKIWSLD 563 Query: 96 SQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVE 155 + TL G+ +V CSF ++ L++ G + + G + + Sbjct: 564 TFS--VMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSG----ECLKTLDGHN 617 Query: 156 EIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVH-QQDCSMGEFINTDK 214 +W + DG ++ + E+ + +Q+ S+ +++ Sbjct: 618 NRLWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQSLQNYMSKGD 677 Query: 215 GENTLELVTCSLDSTIVAWN 234 N L+ +LD + +N Sbjct: 678 WTNAF-LLAMTLDHPMRLFN 696 Score = 58.6 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 43/245 (17%), Positives = 88/245 (35%), Gaps = 35/245 (14%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF--AGTLTGYGESVISCSFT 118 ++ H D + ++ + + T DN A +W + KF G+ +V + Sbjct: 384 YEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLP 443 Query: 119 S---EGG--FLVTADMSGKV--LVHMGQKGGAQWKLASQMQEVEE-----IVWLKTHPTI 166 + +G FL+TA + + ++ + I L P Sbjct: 444 NIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPND 503 Query: 167 ARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSL 226 + FA + D + + N ++G LE ++ H++ F DK L T S Sbjct: 504 S-IFATASYDKTCKIW--NLENGELEATLAN--HKRGLWDVSFCQYDKL-----LATSSG 553 Query: 227 DSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVI 286 D T+ W+ F + + A + + +++C +GL+ + Sbjct: 554 DKTVKIWSL----DTFSVMKTLEGHTNAVQRCSFINKQKQ------LISC-GADGLIKIW 602 Query: 287 NCNNG 291 +C++G Sbjct: 603 DCSSG 607 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 23/133 (17%), Positives = 50/133 (37%), Gaps = 13/133 (9%) Query: 107 GYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTI 166 + + + + S + TA + + G +L + + + +W + Sbjct: 489 AHEKDINALSVSPNDSIFATASYDKTCKIWNLENG----ELEATLANHKRGLWDVSFCQY 544 Query: 167 ARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSL 226 + A + D +V + + S+ + + G H FIN K +L++C Sbjct: 545 DKLLATSSGDKTVKIWSL--DTFSVMKTLEG--HTNAVQRCSFINKQK-----QLISCGA 595 Query: 227 DSTIVAWNCFTGQ 239 D I W+C +G+ Sbjct: 596 DGLIKIWDCSSGE 608 >5WJC-A nrPDB Length = 430 Score = 59.0 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 45/108 (41%), Gaps = 12/108 (11%) Query: 39 DEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTSHSQ 97 D +N +EEA +V H+ ++ A+ +P N L+ T D LW Sbjct: 264 DTRLNPEEEAPKV---------IQAHSKAINAVAINPFNDYLLATASADKTVALW-DLRN 313 Query: 98 PPKFAGTLTGYGESVISCSFT-SEGGFLVTADMSGKVLVHMGQKGGAQ 144 P + TL G+ + V ++ + L ++ +V + +K G + Sbjct: 314 PYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEE 361 Score = 47.8 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 32/209 (15%), Positives = 74/209 (35%), Gaps = 28/209 (13%) Query: 61 FDKHTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTS----HSQPPKFAGTLTGYGESVISC 115 + +HTD V + HP + L+ + D + + + PK + + +++ + Sbjct: 231 YHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPK---VIQAHSKAINAV 287 Query: 116 SFTS-EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGA 174 + L TA V + +L + +E+ L+ P A + Sbjct: 288 AINPFNDYLLATASADKTVALW--DLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSS 345 Query: 175 TDGSVWCYQINE----------QDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTC 224 TD V + + + +DGS E L H S + ++ + + Sbjct: 346 TDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNER----WVVGSL 401 Query: 225 SLDSTIVAW---NCFTGQQLFKITQAEIK 250 + D+ + W G+ +++ +++ Sbjct: 402 ADDNILQIWSPSRVIWGRDHVQVSPRDLE 430 >6F3T-A nrPDB Length = 608 Score = 58.6 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 62/356 (17%), Positives = 120/356 (33%), Gaps = 70/356 (19%) Query: 19 PTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSL------TYFDKHTDSVFAIG 72 P + +P+ ++D D++MN E V + + L T+ + + + A+ Sbjct: 227 PNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAY-QGLTAVD 285 Query: 73 HHPNLPLVCTGGGDNLAHLWT------------------SHSQPPKF-----------AG 103 + L+ G D+ +W+ Sbjct: 286 VTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELK 345 Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 L G+ V SF+ + +L+++ G V + Q + + VW Sbjct: 346 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT----FTCLVGYKGHNYPVWDTQF 401 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 F G D + ++ +G H D + F N+ + T Sbjct: 402 SPYGYYFVSGGHDRVARLWAT--DHYQPLRIFAG--HLADVNCTRFHP-----NSNYVAT 452 Query: 224 CSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLL 283 S D T+ W+ G + T G + P SL+ +P N +A G+ +G + Sbjct: 453 GSADRTVRLWDVLNGNCVRIFT-----GHKGPIHSLTFSP------NGRFLATGATDGRV 501 Query: 284 AVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYD 339 + + +G V ELK D ++ S+ +S ++A G + + L+D Sbjct: 502 LLWDIGHG------LMVGELKGHTD----TVCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 21/94 (22%), Positives = 36/94 (38%), Gaps = 2/94 (2%) Query: 53 MSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESV 112 ++ N + F H + ++ PN + TG D LW G L G+ ++V Sbjct: 465 LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW--DIGHGLMVGELKGHTDTV 522 Query: 113 ISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWK 146 S F+ +G L + M V + K + Sbjct: 523 CSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLE 556 >3BG0-A nrPDB Length = 316 Score = 58.2 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 24/143 (16%), Positives = 46/143 (32%), Gaps = 9/143 (6%) Query: 72 GHHPN-LPLVCTGGGDNLAHLWTSHSQPP-KFAGTLTGYGESVISCSFTSEGGF----LV 125 G PN + +GG DNL LW K L + + V ++ G + Sbjct: 173 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 Query: 126 TADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQIN 185 + G+V + + + + ++VW + A A D V ++ + Sbjct: 233 SCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 Query: 186 -EQDGSLEQLMSGFVHQQDCSMG 207 + ++ Q S Sbjct: 293 VDGQWVCISDVNKG--QGSVSAS 313 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 36/248 (14%), Positives = 78/248 (31%), Gaps = 27/248 (10%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE--G 121 H D + + T D ++ + L G+ V ++ G Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 122 GFLVTADMSGKVLVHMGQKGGAQ--WKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 L + KV++ + G + + A V + W A G++DG++ Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPH--DYGLILACGSSDGAI 129 Query: 180 WCYQ-INEQDGSLEQLMSGFVHQQDC------------SMGEFINTDKGENTLELVTCSL 226 E ++++ + H C S+ + + K + Sbjct: 130 SLLTYTGEGQWEVKKINNA--HTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGC 187 Query: 227 DSTIVAWNCFTGQQLFKITQAEIKGLEAPWI-SLSLAPETLTKGNSGVVACGSNNGLLAV 285 D+ I W Q + + E W+ ++ AP + +A S +G + + Sbjct: 188 DNLIKLWKEEEDGQWKEEQKLEAHSD---WVRDVAWAPSIGLP--TSTIASCSQDGRVFI 242 Query: 286 INCNNGGA 293 C++ + Sbjct: 243 WTCDDASS 250 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 39/192 (20%), Positives = 64/192 (33%), Gaps = 20/192 (10%) Query: 106 TGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVW--LKTH 163 T + + + G L T V + + GG L + ++ E VW H Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQ--ILIADLRGHEGPVWQVAWAH 67 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 P A + D V ++ +G H + + D G L L Sbjct: 68 PMYGNILASCSYDRKVIIWREENGTWEKSHEHAG--HDSSVNSVCWAPHDYG---LILAC 122 Query: 224 CSLDSTIVAWNCFTGQ---QLFKITQAEIKGLEAPWISLSLAPETLTKGNSGV------- 273 S D I +TG+ ++ KI A G A + ++ P +L SG Sbjct: 123 GSSDGAISLL-TYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKR 181 Query: 274 VACGSNNGLLAV 285 A G + L+ + Sbjct: 182 FASGGCDNLIKL 193 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 37/102 (36%), Gaps = 13/102 (12%) Query: 61 FDKHTDSVFAIGHHPN----LPLVCTGGGDNLAHLWT-----SHSQPPKFAGTLTGYGES 111 + H+D V + P+ + + D +WT S++ PK L + + Sbjct: 208 LEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKL---LHKFNDV 264 Query: 112 VISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQE 153 V S++ L + KV + G QW S + + Sbjct: 265 VWHVSWSITANILAVSGGDNKVTLWKESVDG-QWVCISDVNK 305 >3JRP-A nrPDB Length = 379 Score = 57.8 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 35/194 (18%), Positives = 63/194 (32%), Gaps = 33/194 (17%) Query: 62 DKHTDSVFAIGHHPNL-------------PLVCTGGGDNLAHLWTSHSQPPKFA--GTLT 106 D H V + P TGG DNL +W +S + TL Sbjct: 144 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLE 203 Query: 107 GYGESVISCSFTSE---GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVE--EIVWLK 161 G+ + V +++ +L + ++ WK + ++E + +++W Sbjct: 204 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK-KTLLKEEKFPDVLWRA 262 Query: 162 THPTIARTFAFGATDGSVWCYQIN-EQDGSLEQLMSGFVHQ-------QDCSMGEFINTD 213 + A D V ++ N E +G VHQ + EF Sbjct: 263 SWSLSGNVLALSGGDNKVTLWKENLEGKWE----PAGEVHQGGGGSGGGGATSKEFDGPC 318 Query: 214 KGENTLELVTCSLD 227 + E L C+ + Sbjct: 319 QNEIDLLFSECNDE 332 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 34/212 (16%), Positives = 68/212 (32%), Gaps = 18/212 (8%) Query: 80 VCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE--GGFLVTADMSGKVLVHM 137 + T D ++ + K TLTG+ V + G L + GKVL+ Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 85 Query: 138 GQKGGAQWKLASQ----MQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQ 193 + G +W + V + W A SV ++ N + Sbjct: 86 EENG--RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII 143 Query: 194 LMSGFVHQQDCSMGEFINTD----KGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEI 249 I D + + + VT D+ + W + + ++ + Sbjct: 144 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK-YNSDAQTYVLESTL 202 Query: 250 KGLEAPWI-SLSLAPETLTKGNSGVVACGSNN 280 +G + W+ ++ +P L + +A S + Sbjct: 203 EG-HSDWVRDVAWSPTVLLRSY---LASVSQD 230 Score = 52.0 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 38/207 (18%), Positives = 62/207 (29%), Gaps = 11/207 (5%) Query: 101 FAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWL 160 + E + G L T + + + G KL + E VW Sbjct: 3 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWR 60 Query: 161 K--THPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENT 218 HP A + DG V ++ S + + VH + ++ + G Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHA--VHSASVNSVQWAPHEYGP-- 116 Query: 219 LELVTCSLDSTIVAWNCFTGQQLFKITQAEIKG-LEAPWISLSLAPETLTKGN--SGVVA 275 L LV S V G I A G A W ++ + G S Sbjct: 117 LLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 176 Query: 276 CGSNNGLLAVINCNNGGAILHLSTVIE 302 G + L+ + N+ L + +E Sbjct: 177 TGGADNLVKIWKYNSDAQTYVLESTLE 203 Score = 44.7 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 38/248 (15%), Positives = 74/248 (29%), Gaps = 50/248 (20%) Query: 64 HTDSVFAIGH-HPNL-PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE- 120 H V+ + HP ++ + D +W + + SV S + Sbjct: 54 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHE 113 Query: 121 -GGFLVTADMSGKVLVHMGQKGG----------------AQWKLASQMQEVEEIVWLKTH 163 G L+ A GKV V ++ G A W A+ ++ E Sbjct: 114 YGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEH-----NG 168 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 +R F G D V ++ N + ++ + + + + L + Sbjct: 169 TKESRKFVTGGADNLVKIWKYNSD--AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLAS 226 Query: 224 CSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPW----ISLSLAPETLTKGN-----SGVV 274 S D T + W + PW + P+ L + + + + Sbjct: 227 VSQDRTCIIW--------------TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLA 272 Query: 275 ACGSNNGL 282 G +N + Sbjct: 273 LSGGDNKV 280 >4J0W-A nrPDB Length = 343 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 55/272 (20%), Positives = 96/272 (35%), Gaps = 34/272 (12%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H+ V + + + +G L +W +Q + T TG+ ++V +F Sbjct: 66 HSSHVLCMAISSDGKYLASGDRSKLILIW--EAQSCQHLYTFTGHRDAVSGLAFRRGTHQ 123 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 L + V V A+ + ++ V + G DG+V ++ Sbjct: 124 LYSTSHDRSVKVWNV----AENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 179 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFK 243 I E E + + HQ IN + +V+ + D ++ W + L Sbjct: 180 IPE-----ESQLVFYGHQGSIDCIHLINEE------HMVSGADDGSVALWGLSKKRPLAL 228 Query: 244 ITQAE----IKGLEAP-WISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLS 298 +A GLE P WIS N+ +VA GS++ + + C G L L Sbjct: 229 QREAHGLRGEPGLEQPFWIS-----SVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLL 283 Query: 299 TVIELKPEQDELDASIESISWSSKFSLMAIGL 330 I L I S+ +SS + G+ Sbjct: 284 CDIPLV-------GFINSLKFSSSGDFLVAGV 308 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 36/201 (17%), Positives = 60/201 (29%), Gaps = 38/201 (18%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 S L F H D+V + + + D +W + TL G+ ++V Sbjct: 98 SCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENS--YVETLFGHQDAVA 155 Query: 114 SCSFTSEGGFLVTADMSGKVLVHMGQKGGA--------QWKLASQMQEVEEIVWLKTHPT 165 + S + G V V + + E E +V Sbjct: 156 ALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINE-EHMV------- 207 Query: 166 IARTFAFGATDGSVWCYQINEQ-----DGSLEQLMSGFVHQQDCSMGE---FINTDKGEN 217 GA DGSV + ++++ L +Q + +NTD Sbjct: 208 ------SGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDL--- 258 Query: 218 TLELVTCSLDSTIVAWNCFTG 238 + T S S + W C G Sbjct: 259 ---VATGSHSSCVRLWQCGEG 276 >4BZK-B nrPDB Length = 297 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 30/161 (18%), Positives = 54/161 (33%), Gaps = 26/161 (16%) Query: 62 DKHTDSVFAIGHHPNL-------------PLVCTGGGDNLAHLWTSHSQPPKFA--GTLT 106 D H V + P TGG DNL +W +S + TL Sbjct: 142 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLE 201 Query: 107 GYGESVISCSFTSE---GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVE--EIVWLK 161 G+ + V +++ +L + ++ WK + ++E + +++W Sbjct: 202 GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK-KTLLKEEKFPDVLWRA 260 Query: 162 THPTIARTFAFGATDGSVWCYQIN-EQDGSLEQLMSGFVHQ 201 + A D V ++ N E +G VHQ Sbjct: 261 SWSLSGNVLALSGGDNKVTLWKENLEGKWE----PAGEVHQ 297 Score = 55.1 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 34/212 (16%), Positives = 68/212 (32%), Gaps = 18/212 (8%) Query: 80 VCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE--GGFLVTADMSGKVLVHM 137 + T D ++ + K TLTG+ V + G L + GKVL+ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 138 GQKGGAQWKLASQ----MQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQ 193 + G +W + V + W A SV ++ N + Sbjct: 84 EENG--RWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII 141 Query: 194 LMSGFVHQQDCSMGEFINTD----KGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEI 249 I D + + + VT D+ + W + + ++ + Sbjct: 142 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK-YNSDAQTYVLESTL 200 Query: 250 KGLEAPWI-SLSLAPETLTKGNSGVVACGSNN 280 +G + W+ ++ +P L + +A S + Sbjct: 201 EG-HSDWVRDVAWSPTVLLRSY---LASVSQD 228 Score = 51.3 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 38/207 (18%), Positives = 62/207 (29%), Gaps = 11/207 (5%) Query: 101 FAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWL 160 + E + G L T + + + G KL + E VW Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVE--GETHKLIDTLTGHEGPVWR 58 Query: 161 K--THPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENT 218 HP A + DG V ++ S + + VH + ++ + G Sbjct: 59 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHA--VHSASVNSVQWAPHEYGP-- 114 Query: 219 LELVTCSLDSTIVAWNCFTGQQLFKITQAEIKG-LEAPWISLSLAPETLTKGN--SGVVA 275 L LV S V G I A G A W ++ + G S Sbjct: 115 LLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 174 Query: 276 CGSNNGLLAVINCNNGGAILHLSTVIE 302 G + L+ + N+ L + +E Sbjct: 175 TGGADNLVKIWKYNSDAQTYVLESTLE 201 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 38/248 (15%), Positives = 74/248 (29%), Gaps = 50/248 (20%) Query: 64 HTDSVFAIGH-HPNL-PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE- 120 H V+ + HP ++ + D +W + + SV S + Sbjct: 52 HEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHE 111 Query: 121 -GGFLVTADMSGKVLVHMGQKGG----------------AQWKLASQMQEVEEIVWLKTH 163 G L+ A GKV V ++ G A W A+ ++ E Sbjct: 112 YGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEH-----NG 166 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 +R F G D V ++ N + ++ + + + + L + Sbjct: 167 TKESRKFVTGGADNLVKIWKYNSD--AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLAS 224 Query: 224 CSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPW----ISLSLAPETLTKGN-----SGVV 274 S D T + W + PW + P+ L + + + + Sbjct: 225 VSQDRTCIIW--------------TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLA 270 Query: 275 ACGSNNGL 282 G +N + Sbjct: 271 LSGGDNKV 278 >4V8M-A7 nrPDB Length = 318 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 33/194 (17%), Positives = 73/194 (37%), Gaps = 21/194 (10%) Query: 105 LTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 L G+ V + ++ G F V+A + + Q G Q+K ++V + + + Sbjct: 63 LEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDN- 121 Query: 165 TIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTC 224 R G D ++ + + G +S H S F + +V+ Sbjct: 122 ---RQIVSGGRDNALRVWNV---KGECMHTLSRGAHTDWVSCVRFSPSLDAP---VIVSG 172 Query: 225 SLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLA 284 D+ + W+ TG+ ++KG S++++P+ + A +G+ Sbjct: 173 GWDNLVKVWDLATGR-----LVTDLKGHTNYVTSVTVSPD------GSLCASSDKDGVAR 221 Query: 285 VINCNNGGAILHLS 298 + + G A+ ++ Sbjct: 222 LWDLTKGEALSEMA 235 Score = 38.9 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 37/227 (16%), Positives = 70/227 (30%), Gaps = 54/227 (23%) Query: 52 DMSNNSLTY-FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQ------------- 97 ++ N Y F HT V ++ P+ + +GG DN +W + Sbjct: 95 NLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTLSRGAHTDW 154 Query: 98 -----------PP-------------------KFAGTLTGYGESVISCSFTSEGGFLVTA 127 P + L G+ V S + + +G ++ Sbjct: 155 VSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASS 214 Query: 128 DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 D G + KG + S+M I + P R + AT+ + + + + Sbjct: 215 DKDGVARLWDLTKG----EALSEMAAGAPINQICFSPN--RYWMCAATEKGIRIFDLENK 268 Query: 188 DGSLEQLMSGFVHQQDCSM-GEFINTDKGENTLELVTCSLDSTIVAW 233 D + HQ + E ++ + L + D+ I W Sbjct: 269 D---IIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVW 312 >6EOJ-D nrPDB Length = 470 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 46/122 (37%), Gaps = 7/122 (5%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 HT+S+ + N T DN+ +W + K L+G+ V SC + E G Sbjct: 176 HTESIRDMAFSSNDSKFVTCSDDNILKIW--NFSNGKQERVLSGHHWDVKSCDWHPEMGL 233 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEE-IVWLKTHPTIARTFAFGATDGSVWCY 182 + +A V + + G S + + + ++ + PT + D S + Sbjct: 234 IASASKDNLVKLWDPRSG----NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 Query: 183 QI 184 I Sbjct: 290 DI 291 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 40/193 (20%), Positives = 75/193 (38%), Gaps = 27/193 (13%) Query: 112 VISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFA 171 + + +T EG LV A SG+ + + + + MQ + V + + Sbjct: 96 IPAIQWTPEGRRLVVATYSGEFSLW----NASSFTFETLMQAHDSAVTTMKYSHDSDWMI 151 Query: 172 FGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIV 231 G DG + +Q N S+ + + H + F + D + VTCS D+ + Sbjct: 152 SGDADGMIKIWQPN---FSMVKEIDA-AHTESIRDMAFSSNDS-----KFVTCSDDNILK 202 Query: 232 AWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNG 291 WN G+Q ++ W PE G++A S + L+ + + +G Sbjct: 203 IWNFSNGKQERVLSGHHWDVKSCDW-----HPEM------GLIASASKDNLVKLWDPRSG 251 Query: 292 GAILHLSTVIELK 304 I S++++ K Sbjct: 252 NCI---SSILKFK 261 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 29/171 (16%), Positives = 55/171 (32%), Gaps = 12/171 (7%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT-SEGG 122 H V + HP + L+ + DNL LW S ++ + +V+ F ++G Sbjct: 218 HHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG--NCISSILKFKHTVLKTRFQPTKGN 275 Query: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 L+ V + + + + W HP F DGS+ + Sbjct: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEW---HPINESMFTLACYDGSLKHF 332 Query: 183 QINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAW 233 + + + + H + + + T + D TI W Sbjct: 333 DLLQNLNEPILTIP-YAHDKCITSLSYNPVGHI-----FATAAKDRTIRFW 377 >5LCW-Q nrPDB Length = 374 Score = 55.5 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 35/171 (20%), Positives = 56/171 (32%), Gaps = 9/171 (5%) Query: 68 VFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTA 127 + ++ + G LW Q K +T + V S S+ S L + Sbjct: 104 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNS--YILSSG 159 Query: 128 DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 SG +H A+ +A+ +E+ L+ P R A G D V + Sbjct: 160 SRSGH--IHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPG 216 Query: 188 DGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 +G L + HQ + N L + D I WN +G Sbjct: 217 EGGWVPLQTFTQHQGAVKAVAWCPWQ--SNVLATGGGTSDRHIRIWNVCSG 265 Score = 44.7 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 65/192 (33%), Gaps = 17/192 (8%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF--AGTLTG 107 +V ++ + + H+ V + P+ + +GG DNL ++W S + T T Sbjct: 169 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 228 Query: 108 YGESVISCSFTS-EGGFLVT--ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 + +V + ++ + L T + + GA +V I+W + Sbjct: 229 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC-SGACLSAVDAHSQVCSILWSPHYK 287 Query: 165 TIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTC 224 + F +W Y + + G ++ + + + Sbjct: 288 ELISGHGFAQNQLVIWKYPTMAK----VAELKGH-------TSRVLSLTMSPDGATVASA 336 Query: 225 SLDSTIVAWNCF 236 + D T+ W CF Sbjct: 337 AADETLRLWRCF 348 >5G04-R nrPDB Length = 499 Score = 55.5 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 35/171 (20%), Positives = 56/171 (32%), Gaps = 9/171 (5%) Query: 68 VFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTA 127 + ++ + G LW Q K +T + V S S+ S L + Sbjct: 229 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNS--YILSSG 284 Query: 128 DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 SG +H A+ +A+ +E+ L+ P R A G D V + Sbjct: 285 SRSGH--IHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPG 341 Query: 188 DGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 +G L + HQ + N L + D I WN +G Sbjct: 342 EGGWVPLQTFTQHQGAVKAVAWCPWQ--SNVLATGGGTSDRHIRIWNVCSG 390 Score = 44.7 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 65/192 (33%), Gaps = 17/192 (8%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF--AGTLTG 107 +V ++ + + H+ V + P+ + +GG DNL ++W S + T T Sbjct: 294 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 353 Query: 108 YGESVISCSFTS-EGGFLVT--ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 + +V + ++ + L T + + GA +V I+W + Sbjct: 354 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC-SGACLSAVDAHSQVCSILWSPHYK 412 Query: 165 TIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTC 224 + F +W Y + + G ++ + + + Sbjct: 413 ELISGHGFAQNQLVIWKYPTMAK----VAELKGH-------TSRVLSLTMSPDGATVASA 461 Query: 225 SLDSTIVAWNCF 236 + D T+ W CF Sbjct: 462 AADETLRLWRCF 473 >4N14-A nrPDB Length = 314 Score = 55.5 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 35/171 (20%), Positives = 56/171 (32%), Gaps = 9/171 (5%) Query: 68 VFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTA 127 + ++ + G LW Q K +T + V S S+ S L + Sbjct: 66 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNS--YILSSG 121 Query: 128 DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 SG +H A+ +A+ +E+ L+ P R A G D V + Sbjct: 122 SRSGH--IHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPG 178 Query: 188 DGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 +G L + HQ + N L + D I WN +G Sbjct: 179 EGGWVPLQTFTQHQGAVKAVAWCPWQ--SNVLATGGGTSDRHIRIWNVCSG 227 Score = 44.7 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 65/192 (33%), Gaps = 17/192 (8%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF--AGTLTG 107 +V ++ + + H+ V + P+ + +GG DNL ++W S + T T Sbjct: 131 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 190 Query: 108 YGESVISCSFTS-EGGFLVT--ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 + +V + ++ + L T + + GA +V I+W + Sbjct: 191 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC-SGACLSAVDAHSQVCSILWSPHYK 249 Query: 165 TIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTC 224 + F +W Y + + G ++ + + + Sbjct: 250 ELISGHGFAQNQLVIWKYPTMAK----VAELKGH-------TSRVLSLTMSPDGATVASA 298 Query: 225 SLDSTIVAWNCF 236 + D T+ W CF Sbjct: 299 AADETLRLWRCF 310 >4GGA-A nrPDB Length = 420 Score = 55.5 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 35/171 (20%), Positives = 56/171 (32%), Gaps = 9/171 (5%) Query: 68 VFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTA 127 + ++ + G LW Q K +T + V S S+ S L + Sbjct: 150 ISSVAWIKEGNYLAVGTSSAEVQLWDVQQQ--KRLRNMTSHSARVGSLSWNS--YILSSG 205 Query: 128 DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 SG +H A+ +A+ +E+ L+ P R A G D V + Sbjct: 206 SRSGH--IHHHDVRVAEHHVATLSGHSQEVCGLRWAP-DGRHLASGGNDNLVNVWPSAPG 262 Query: 188 DGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 +G L + HQ + N L + D I WN +G Sbjct: 263 EGGWVPLQTFTQHQGAVKAVAWCPWQ--SNVLATGGGTSDRHIRIWNVCSG 311 Score = 44.7 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 65/192 (33%), Gaps = 17/192 (8%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF--AGTLTG 107 +V ++ + + H+ V + P+ + +GG DNL ++W S + T T Sbjct: 215 DVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQ 274 Query: 108 YGESVISCSFTS-EGGFLVT--ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 + +V + ++ + L T + + GA +V I+W + Sbjct: 275 HQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC-SGACLSAVDAHSQVCSILWSPHYK 333 Query: 165 TIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTC 224 + F +W Y + + G ++ + + + Sbjct: 334 ELISGHGFAQNQLVIWKYPTMAK----VAELKGH-------TSRVLSLTMSPDGATVASA 382 Query: 225 SLDSTIVAWNCF 236 + D T+ W CF Sbjct: 383 AADETLRLWRCF 394 >5L9T-R nrPDB Length = 493 Score = 54.7 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 37/189 (19%), Positives = 61/189 (32%), Gaps = 32/189 (16%) Query: 66 DSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLV 125 DSV ++G LV G +W + K L G+ V + ++ +E L Sbjct: 230 DSVTSVGWSERGNLVAVGTHKGFVQIW--DAAAGKKLSMLEGHTARVGALAWNAEQ--LS 285 Query: 126 TADMSGKVLVHM--GQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY- 182 + +L ++ +L QEV + W H + A G D + + Sbjct: 286 SGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH----QLLASGGNDNKLLVWN 341 Query: 183 -------QINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNC 235 Q + + + ++ HQ L + D I WN Sbjct: 342 HSSLSPVQQYTEHLAAVKAIAWSPHQ--------------HGLLASGGGTADRCIRFWNT 387 Query: 236 FTGQQLFKI 244 TGQ L I Sbjct: 388 LTGQPLQCI 396 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 38/179 (21%), Positives = 63/179 (35%), Gaps = 21/179 (11%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT-SEGG 122 H V + + L+ +GG DN +W S P T + +V + +++ + G Sbjct: 312 HRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSP--VQQYTEHLAAVKAIAWSPHQHG 369 Query: 123 FLV----TADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGS 178 L TAD + + G + +V + W K + T + Sbjct: 370 LLASGGGTADRCIRFWNTLT---GQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQIL 426 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFT 237 VW Y SL Q+ H + GE +VT + D T+ WN F+ Sbjct: 427 VWKYP------SLTQVAKLTGHSYRVLY--LAMSPDGEA---IVTGAGDETLRFWNVFS 474 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 34/196 (17%), Positives = 68/196 (34%), Gaps = 19/196 (9%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 + L+ + HT V A+ N + +G D + + P + L G+ + V Sbjct: 260 AGKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVC 317 Query: 114 SCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAF- 172 ++++ L + K+LV + + V+ I W P A Sbjct: 318 GLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWS---PHQHGLLASG 374 Query: 173 -GATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT--CSLDST 229 G D + + ++G Q + + N ++ ELV+ + Sbjct: 375 GGTADRCIRFWN----------TLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQ 424 Query: 230 IVAWNCFTGQQLFKIT 245 I+ W + Q+ K+T Sbjct: 425 ILVWKYPSLTQVAKLT 440 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 28/154 (18%), Positives = 62/154 (40%), Gaps = 20/154 (12%) Query: 43 NDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNL-PLVCTGGG--DNLAHLWTSHSQPP 99 ND++ + S + + + +H +V AI P+ L+ +GGG D W + + P Sbjct: 333 NDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQP 392 Query: 100 KFAGTLTGYGESVISCSFTSEGGFLVTAD--MSGKVLVHMGQKGGAQWKLASQMQEVE-- 155 TG V + +++ LV+ ++LV ++ +Q+ ++ Sbjct: 393 -LQCIDTG--SQVCNLAWSKHANELVSTHGYSQNQILVW-------KYPSLTQVAKLTGH 442 Query: 156 --EIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 +++L P GA D ++ + + + Sbjct: 443 SYRVLYLAMSP-DGEAIVTGAGDETLRFWNVFSK 475 Score = 37.4 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 25/153 (16%), Positives = 47/153 (30%), Gaps = 17/153 (11%) Query: 84 GGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGA 143 G +LW++ + L+ G+SV S ++ G + G V + G Sbjct: 204 GLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKK 263 Query: 144 QWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQ-- 201 L V + W A + G+ D + I E+ + G + Sbjct: 264 LSMLEGHTARVGALAWN------AEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVC 317 Query: 202 QDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 + L + D+ ++ WN Sbjct: 318 GLKWSTDHQL---------LASGGNDNKLLVWN 341 >4XYI-A nrPDB Length = 430 Score = 54.3 bits (129), Expect = 9e-08, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 52/144 (36%), Gaps = 14/144 (9%) Query: 64 HTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT-SEG 121 H V + +P N L+ T D+ LW + TL G+ + V + ++ + Sbjct: 280 HEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRL-HTLEGHEDEVYNVQWSPHDE 338 Query: 122 GFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVW-----------LKTHPTIARTF 170 LVT+ +V V K G + + E+++ L +P Sbjct: 339 PILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVL 398 Query: 171 AFGATDGSVWCYQINEQDGSLEQL 194 A A D + + ++ + + L Sbjct: 399 ASLADDNILQIWSPSKVIWASDSL 422 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 31/100 (31%), Gaps = 14/100 (14%) Query: 55 NNSLTYFDKHTDSVFAIGHHPN-LPLVCTGGGDNLAHLW------------TSHSQPPKF 101 N L + H D V+ + P+ P++ T D +W S P+ Sbjct: 315 NQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPEL 374 Query: 102 AGTLTGYGESVISCSFT-SEGGFLVTADMSGKVLVHMGQK 140 G+ V S+ + L + + + K Sbjct: 375 MFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSK 414 >6EMK-B nrPDB Length = 303 Score = 54.3 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 38/188 (20%), Positives = 65/188 (34%), Gaps = 11/188 (5%) Query: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGES 111 D+ + S+ KH V + HPN + + D +W T S Sbjct: 103 DVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED-DTS 161 Query: 112 VISCSFTSEGGFLVTADMSGKVLVHM--GQKGGAQWKLASQMQEVEEIVWLKTHPTIART 169 + S S S+G L A+ G V + K ++ + + + + Sbjct: 162 LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH 221 Query: 170 FAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDST 229 A + D + + I + D LE + G HQ+ F ++ LVT S D Sbjct: 222 LATCSADHTARVWSI-DDDFKLETTLDG--HQRWVWDCAF-----SADSAYLVTASSDHY 273 Query: 230 IVAWNCFT 237 + W+ T Sbjct: 274 VRLWDLST 281 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 42/221 (19%), Positives = 71/221 (32%), Gaps = 55/221 (24%) Query: 79 LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMG 138 L+ T G N L+ + P + G+ +V S SF + ++VT+ G + V Sbjct: 46 LLATAGHQN-VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 Query: 139 QKGG--AQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQIN----------E 186 + +K + + EV HP DG++ + + E Sbjct: 105 RSPSIPRNYKHNAPVNEV------VIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPE 157 Query: 187 QDGSLEQL--------MSGFVHQQDCSMGEFIN-TDKGE--------------------- 216 D SL+ L ++ + +C + E N TD Sbjct: 158 DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS 217 Query: 217 NTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWI 257 + L TCS D T W+ FK+ W+ Sbjct: 218 DVKHLATCSADHTARVWSI---DDDFKLETTL--DGHQRWV 253 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 43/247 (17%), Positives = 81/247 (32%), Gaps = 40/247 (16%) Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 LV+A + G + +Q + V + A V Y Sbjct: 5 LVSAGYDHTIRFWEALTG----VCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYD 59 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFK 243 I + + G H+ + + F ++ +VT S D TI W + Sbjct: 60 IRTTNPNPVASFEG--HRGNVTSVSFQQDNRW-----MVTSSEDGTIKVW------DVRS 106 Query: 244 ITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIEL 303 + AP E + N G + +G + + + +L Sbjct: 107 PSIPRNYKHNAP------VNEVVIHPNQGELISCDRDGNIRIWDLGEN------QCTHQL 154 Query: 304 KPEQDELDASIESISWSSKFSLMAIGLVCGEILLY------DTSAWRVRHKFVLEDS-VT 356 PE D S++S+S +S S++A G ++ D S + KF + +T Sbjct: 155 TPED---DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYIT 211 Query: 357 KLMFDND 363 +++ +D Sbjct: 212 RILLSSD 218 >5A9Q-7 nrPDB Length = 360 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 33/183 (18%), Positives = 63/183 (34%), Gaps = 15/183 (8%) Query: 108 YGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKT--HPT 165 + + + SF G + T V V + G W + + VW T HP Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESG-DWHCTASWKTHSGSVWRVTWAHPE 69 Query: 166 IARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVH--------QQDCSMGEFINTDKGEN 217 + A + D + ++ E G + G H S+ + K Sbjct: 70 FGQVLASCSFDRTAAVWE--EIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMG 127 Query: 218 TLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACG 277 + L TCS D + + L + + + +S P + ++ +S ++A G Sbjct: 128 LM-LATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSS-SRAHSPMIAVG 185 Query: 278 SNN 280 S++ Sbjct: 186 SDD 188 Score = 46.6 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 28/183 (15%), Positives = 56/183 (30%), Gaps = 20/183 (10%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPP-KFAGTLTGYGESVISCSFTSE-- 120 H D + + + + T D +W + + SV ++ Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIAR----------TF 170 G L + V G + KL Q V+ + + ++ Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 171 AFGATDGSVWCYQINE----QDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSL 226 A + DG V Y+ + SL+ +S + CS + + ++ + S Sbjct: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKL---SCSCISWNPSSSRAHSPMIAVGSD 187 Query: 227 DST 229 DS+ Sbjct: 188 DSS 190 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 28/174 (16%), Positives = 55/174 (31%), Gaps = 27/174 (15%) Query: 51 VDMSNNSLTYFDKHTDSVFAIGHHP-----NLPLVCTGGGDNL------AHLWTSHSQPP 99 +++S SL + S I +P + P++ G D+ ++ + Sbjct: 148 MNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTR 207 Query: 100 KFAG--TLTGYGESVISCSFTSEGG----FLVTADMSGKVLV------HMGQKGGA---Q 144 K+A TL + V +F G L A ++ + GG + Sbjct: 208 KYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFE 267 Query: 145 WKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ-INEQDGSLEQLMSG 197 + +Q VW + A DG V ++ + ++ G Sbjct: 268 IHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKG 321 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 23/57 (40%), Gaps = 1/57 (1%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPP-KFAGTLTGYGESVISCS 116 FD H V+ + + ++ + G D LW ++ K G L G G V S Sbjct: 274 FDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSS 330 >3JB9-g nrPDB Length = 558 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 76/226 (33%), Gaps = 29/226 (12%) Query: 64 HTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGG 122 HT + + P + L+ +G DN +W + T G+ + SF+ +G Sbjct: 265 HTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDR-SLLRTFQGHARPIRDLSFSQDGR 323 Query: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQ--EVEEIVWLKTHPTIARTFAFGATDGSVW 180 ++ + + + G K + + V + P F G D + Sbjct: 324 SFLSTSFDKTIKLWDTELG----KCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRIL 379 Query: 181 CYQINEQDGSLEQLMSGFVHQ-QDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQ 239 + I D ++ + H + F+ EN VT S DS++ W T Sbjct: 380 QFDIRSPD-----IVQAYDHHLGGINSITFL-----ENGKRFVTTSDDSSMRFWEYGTPV 429 Query: 240 QLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAV 285 + + I++ P + N +AC S + + V Sbjct: 430 PIKFVAD----------IAMHSMPRVALRPNGKSIACQSLDNCIYV 465 >6HHQ-h nrPDB Length = 319 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 46/249 (18%), Positives = 89/249 (35%), Gaps = 35/249 (14%) Query: 67 SVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF---AGTLTGYGESVISCSFTSEGGF 123 S+ PN L+ + D W KF + G+ V C+ T++G + Sbjct: 22 SLATSAGQPN--LLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAY 79 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 ++A + + G + +V + K A G+ D ++ + Sbjct: 80 ALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKK----ASMIISGSRDKTIKVWT 135 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKG-ENTLELVTCSLDSTIVAWNCFTGQQLF 242 I G + G H S + +K ++++ +++ D + AWN Sbjct: 136 I---KGQCLATLLG--HNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWN-------- 182 Query: 243 KITQAEIKGLEAPWISLSLAPETLTKGNSG-VVACGSNNGLLAVINCNNGGAILHLSTVI 301 + Q +I+ +I + TLT G ++A +G + + N A+ LS Sbjct: 183 -LNQFQIEAD---FIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSA-- 236 Query: 302 ELKPEQDEL 310 QDE+ Sbjct: 237 -----QDEV 240 Score = 33.9 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 24/160 (15%), Positives = 54/160 (33%), Gaps = 9/160 (5%) Query: 80 VCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQ 139 + + G D + W + + G+ ++ + + + +G + +A G++++ Sbjct: 169 IISAGNDKMVKAWNLNQF--QIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLA 226 Query: 140 KGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFV 199 A + L++Q +E+ L P A AT V+ L +G+ Sbjct: 227 AKKAMYTLSAQ----DEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYS 282 Query: 200 HQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQ 239 + + G+ D+ I W T Sbjct: 283 KAAEPHAVSLAWSADGQTLF---AGYTDNVIRVWQVMTAN 319 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 18/128 (14%), Positives = 36/128 (28%), Gaps = 13/128 (10%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF--- 117 F H V ++ ++ +G D +WT Q TL G+ + V Sbjct: 103 FVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQC---LATLLGHNDWVSQVRVVPN 159 Query: 118 ---TSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGA 174 + +++A V + + + + T A Sbjct: 160 EKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTL----TASPDGTLIASAG 215 Query: 175 TDGSVWCY 182 DG + + Sbjct: 216 KDGEIMLW 223 >5OPT-p nrPDB Length = 318 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 32/194 (16%), Positives = 73/194 (37%), Gaps = 21/194 (10%) Query: 105 LTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 L G+ V + ++ G F V+A + + Q G Q K ++V + + + Sbjct: 63 LEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDN- 121 Query: 165 TIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTC 224 R G D ++ + + G + H S F + + +V+ Sbjct: 122 ---RQIVSGGRDNALRVWNV---KGECLHTLGRGAHTDWVSCVRFSPSLETP---LIVSG 172 Query: 225 SLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLA 284 D+ + W+ +G+ L ++KG S++++P+ + A +G+ Sbjct: 173 GWDNLVKVWDIASGRLL-----TDLKGHTNYITSVTVSPD------GSLCASSDKDGVAR 221 Query: 285 VINCNNGGAILHLS 298 + + G A+ ++ Sbjct: 222 LWDLTKGEALSEMA 235 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 35/217 (16%), Positives = 69/217 (31%), Gaps = 51/217 (23%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWT-------------------------SH 95 F HT V ++ P+ + +GG DN +W S Sbjct: 105 FLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSL 164 Query: 96 SQP------------------PKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHM 137 P + L G+ + S + + +G ++D G + Sbjct: 165 ETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWD 224 Query: 138 GQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSG 197 KG + S+M I + P R + AT+ + + + +D +E ++ Sbjct: 225 LTKG----EALSEMAAGAPINQICFSPN--RYWMCAATEKGIRIFDLENKDVIVE--LAP 276 Query: 198 FVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 Q+ E ++ + L + D+ I W+ Sbjct: 277 EAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWS 313 Score = 35.9 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 48/142 (33%), Gaps = 19/142 (13%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW--TSHSQPPKFAGTLTGYGES 111 S LT HT+ + ++ P+ L + D +A LW T + A G Sbjct: 185 SGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA-----GAP 239 Query: 112 VISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQ-------EVEEIVWLKTHP 164 + F+ ++ A + + + +LA + Q E I W Sbjct: 240 INQICFSPNRYWMCAAT-EKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAW----S 294 Query: 165 TIARTFAFGATDGSVWCYQINE 186 T G TD + + ++E Sbjct: 295 ADGNTLYSGYTDNVIRVWSVSE 316 >3DM0-A nrPDB Length = 694 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 94/243 (38%), Gaps = 33/243 (13%) Query: 64 HTDSVFAIGHH-PNLPLVCTGGGDNLAHLWTSHSQPPKFAGT----LTGYGESVISCSFT 118 HTD V AI N ++ + D LW ++ K G LTG+ V + Sbjct: 381 HTDMVTAIATPIDNADIIVSASRDKSIILW-KLTKDDKAYGVAQRRLTGHSHFVEDVVLS 439 Query: 119 SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGS 178 S+G F ++ G++ + G + + ++V + + + R + D + Sbjct: 440 SDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDN----RQIVSASRDRT 495 Query: 179 VWCYQINEQDGSLEQLMS--GFVHQQDCSMGEFINTDKGENTLE--LVTCSLDSTIVAWN 234 + + G + +S G H+ S F NTL+ +V+ S D T+ WN Sbjct: 496 IKLWNTL---GECKYTISEGGEGHRDWVSCVRF-----SPNTLQPTIVSASWDKTVKVWN 547 Query: 235 CFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAI 294 + T A G + +++++P+ + A G +G++ + + G + Sbjct: 548 --LSNCKLRSTLAGHTGYVS---TVAVSPD------GSLCASGGKDGVVLLWDLAEGKKL 596 Query: 295 LHL 297 L Sbjct: 597 YSL 599 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 29/180 (16%), Positives = 66/180 (36%), Gaps = 34/180 (18%) Query: 82 TGGGDNLAHLW--TSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMG- 138 +G D LW + +F G+ + V+S +F+ + +V+A + + Sbjct: 447 SGSWDGELRLWDLAAGVSTRRFV----GHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTL 502 Query: 139 -------QKGGAQWKLASQMQEVEEIVWLKTHP-TIARTFAFGATDGSVWCYQINEQDGS 190 +GG + + + ++ P T+ T + D +V + N + Sbjct: 503 GECKYTISEGGEGHR--------DWVSCVRFSPNTLQPTIVSASWDKTVKVW--NLSNCK 552 Query: 191 LEQLMSGFVHQQDCSMGEFINTDKGENTLELV-TCSLDSTIVAWNCFTGQQLFKITQAEI 249 L ++G H S ++ D L + D ++ W+ G++L+ + + Sbjct: 553 LRSTLAG--HTGYVSTVA-VSPDGS-----LCASGGKDGVVLLWDLAEGKKLYSLEANSV 604 Score = 30.1 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 22/134 (16%), Positives = 37/134 (27%), Gaps = 49/134 (36%) Query: 61 FDKHTDSVFAI------------------------------------GHH---------P 75 F HT V ++ GH P Sbjct: 468 FVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSP 527 Query: 76 NL--PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKV 133 N P + + D +W + K TL G+ V + + + +G + G V Sbjct: 528 NTLQPTIVSASWDKTVKVW--NLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVV 585 Query: 134 LVHMGQKGGAQWKL 147 L+ +G + L Sbjct: 586 LLWDLAEGKKLYSL 599 >5WLC-LO nrPDB Length = 923 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 59/300 (19%), Positives = 106/300 (35%), Gaps = 38/300 (12%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H DS ++ + P+ V T D +W T + SV + F G Sbjct: 344 HFDSTNSLAYSPDGSRVVTASEDGKIKVW--DITSGFCLATFEEHTSSVTAVQFAKRGQV 401 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVW--LKTHPTIARTFAFGATDGSVWC 181 + ++ + G V +++ E I + L P+ A + + Sbjct: 402 MFSSSLDGTVRAWDL----IRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHV 457 Query: 182 YQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQL 241 + + Q G L +SG H+ S F + L + S D TI W+ F Sbjct: 458 WSV--QTGQLLDALSG--HEGPVSCLSFSQENSV-----LASASWDKTIRIWSIF----- 503 Query: 242 FKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNG---GAILHLS 298 + Q E + + ++LS+ P+ VA + G +++ N + G I Sbjct: 504 GRSQQVEPIEVYSDVLALSMRPDGKE------VAVSTLKGQISIFNIEDAKQVGNIDCRK 557 Query: 299 TVIELKPEQDELDASIESIS---WSSKFSLMAIGLVCG----EILLYDTSAWRVRHKFVL 351 +I + QD A S + +S + +V G I LYD + +F++ Sbjct: 558 DIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIV 617 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 41/205 (20%), Positives = 68/205 (33%), Gaps = 28/205 (13%) Query: 84 GGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGA 143 G L L Q + G+ +S S +++ +G +VTA GK+ V G Sbjct: 320 GSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG-- 377 Query: 144 QWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQD 203 + +E V + + DG+V + L + + Sbjct: 378 --FCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW-------DLIRYRNFRTFTGT 428 Query: 204 --CSMGEFINTDKGENTLELVTCSLDS-TIVAWNCFTGQQLFKITQAEIKGLEAPWISLS 260 GE SLD+ I W+ TGQ L ++ G E P LS Sbjct: 429 ERIQFNCLAVDPSGEVV---CAGSLDNFDIHVWSVQTGQLLDALS-----GHEGPVSCLS 480 Query: 261 LAPETLTKGNSGVVACGSNNGLLAV 285 + E + V+A S + + + Sbjct: 481 FSQE------NSVLASASWDKTIRI 499 Score = 44.7 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 29/75 (38%), Gaps = 1/75 (1%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGT-LTGYGESVISCSFTSEGG 122 H + ++ + + T D A +W+ S+ A T G+ + V+ F+ + Sbjct: 145 HFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQE 204 Query: 123 FLVTADMSGKVLVHM 137 + T G V V Sbjct: 205 KIYTVSKDGAVFVWE 219 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 48/237 (20%), Positives = 79/237 (33%), Gaps = 34/237 (14%) Query: 50 EVDMSNNSLTYFDKH-----TDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPP-KFAG 103 EVD+S S KH V + HP L+ G L+ P Sbjct: 240 EVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLY---DLPDFTLIQ 296 Query: 104 TLTGYGESVISCSFTSEGGFLV-TADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKT 162 L+ V + S G +L + G++LV+ Q ++ + Q + L Sbjct: 297 QLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQ---SESYILKQQGHFDSTNSLAY 353 Query: 163 HPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELV 222 P +R + DG + + I G H + +F +G+ Sbjct: 354 SPDGSRVV-TASEDGKIKVWDITS--GFCLATFE--EHTSSVTAVQFAK--RGQVMF--- 403 Query: 223 TCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSN 279 + SLD T+ AW+ + T E + L++ P SG V C + Sbjct: 404 SSSLDGTVRAWDLIRYRNFRTFTGTE----RIQFNCLAVDP-------SGEVVCAGS 449 Score = 35.1 bits (79), Expect = 0.067, Method: Composition-based stats. Identities = 18/149 (12%), Positives = 49/149 (32%), Gaps = 9/149 (6%) Query: 42 MNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-TSHSQPPK 100 +++D A+ V+ ++ + + A+ P+ L G +W T + Sbjct: 73 IDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDR 131 Query: 101 FAG------TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEV 154 G+ + + S +++ + F++T + + A+ Sbjct: 132 QFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVD-SEEKNLAATTFNGH 190 Query: 155 EEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 + V + DG+V+ ++ Sbjct: 191 RDYVMGAFFSHDQEKIYTVSKDGAVFVWE 219 >5I2T-A nrPDB Length = 742 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 59/300 (19%), Positives = 106/300 (35%), Gaps = 38/300 (12%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H DS ++ + P+ V T D +W T + SV + F G Sbjct: 369 HFDSTNSLAYSPDGSRVVTASEDGKIKVW--DITSGFCLATFEEHTSSVTAVQFAKRGQV 426 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVW--LKTHPTIARTFAFGATDGSVWC 181 + ++ + G V +++ E I + L P+ A + + Sbjct: 427 MFSSSLDGTVRAWDL----IRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHV 482 Query: 182 YQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQL 241 + + Q G L +SG H+ S F + L + S D TI W+ F Sbjct: 483 WSV--QTGQLLDALSG--HEGPVSCLSFSQENSV-----LASASWDKTIRIWSIF----- 528 Query: 242 FKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNG---GAILHLS 298 + Q E + + ++LS+ P+ VA + G +++ N + G I Sbjct: 529 GRSQQVEPIEVYSDVLALSMRPDGKE------VAVSTLKGQISIFNIEDAKQVGNIDCRK 582 Query: 299 TVIELKPEQDELDASIESIS---WSSKFSLMAIGLVCG----EILLYDTSAWRVRHKFVL 351 +I + QD A S + +S + +V G I LYD + +F++ Sbjct: 583 DIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIV 642 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 41/205 (20%), Positives = 68/205 (33%), Gaps = 28/205 (13%) Query: 84 GGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGA 143 G L L Q + G+ +S S +++ +G +VTA GK+ V G Sbjct: 345 GSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSG-- 402 Query: 144 QWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQD 203 + +E V + + DG+V + L + + Sbjct: 403 --FCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW-------DLIRYRNFRTFTGT 453 Query: 204 --CSMGEFINTDKGENTLELVTCSLDS-TIVAWNCFTGQQLFKITQAEIKGLEAPWISLS 260 GE SLD+ I W+ TGQ L ++ G E P LS Sbjct: 454 ERIQFNCLAVDPSGEVV---CAGSLDNFDIHVWSVQTGQLLDALS-----GHEGPVSCLS 505 Query: 261 LAPETLTKGNSGVVACGSNNGLLAV 285 + E + V+A S + + + Sbjct: 506 FSQE------NSVLASASWDKTIRI 524 Score = 44.7 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 29/75 (38%), Gaps = 1/75 (1%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGT-LTGYGESVISCSFTSEGG 122 H + ++ + + T D A +W+ S+ A T G+ + V+ F+ + Sbjct: 170 HFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQE 229 Query: 123 FLVTADMSGKVLVHM 137 + T G V V Sbjct: 230 KIYTVSKDGAVFVWE 244 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 48/237 (20%), Positives = 79/237 (33%), Gaps = 34/237 (14%) Query: 50 EVDMSNNSLTYFDKH-----TDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPP-KFAG 103 EVD+S S KH V + HP L+ G L+ P Sbjct: 265 EVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLY---DLPDFTLIQ 321 Query: 104 TLTGYGESVISCSFTSEGGFLV-TADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKT 162 L+ V + S G +L + G++LV+ Q ++ + Q + L Sbjct: 322 QLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQ---SESYILKQQGHFDSTNSLAY 378 Query: 163 HPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELV 222 P +R + DG + + I G H + +F +G+ Sbjct: 379 SPDGSRVV-TASEDGKIKVWDITS--GFCLATFE--EHTSSVTAVQFAK--RGQVMF--- 428 Query: 223 TCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSN 279 + SLD T+ AW+ + T E + L++ P SG V C + Sbjct: 429 SSSLDGTVRAWDLIRYRNFRTFTGTE----RIQFNCLAVDP-------SGEVVCAGS 474 Score = 35.1 bits (79), Expect = 0.067, Method: Composition-based stats. Identities = 18/149 (12%), Positives = 49/149 (32%), Gaps = 9/149 (6%) Query: 42 MNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-TSHSQPPK 100 +++D A+ V+ ++ + + A+ P+ L G +W T + Sbjct: 98 IDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDR 156 Query: 101 FAG------TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEV 154 G+ + + S +++ + F++T + + A+ Sbjct: 157 QFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVD-SEEKNLAATTFNGH 215 Query: 155 EEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 + V + DG+V+ ++ Sbjct: 216 RDYVMGAFFSHDQEKIYTVSKDGAVFVWE 244 >6CHG-A nrPDB Length = 312 Score = 52.8 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 37/234 (15%), Positives = 78/234 (33%), Gaps = 28/234 (11%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H + + + P+ + +G D + +H + + G+ VIS + ++G Sbjct: 53 HKECINCLCWSPDSKCIASGSEDFTVEI--THIIYGRIRRLM-GHTAPVISICYNNKGNI 109 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 L ++ M + G A L + + +V + + + G+ DG + + Sbjct: 110 LCSSSMDESIKEWHVLSGTA---LKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFD 166 Query: 184 ----------INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAW 233 ++D E G V LV SLD+ + W Sbjct: 167 TESGHCLKTLTYDKDWIAE---DGVVPISTVKFSR-------NGKFLLVK-SLDNVVKLW 215 Query: 234 NCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVIN 287 +T + + + +A +G +V G+++G + V N Sbjct: 216 E-YTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWN 268 >4V6W-Ag nrPDB Length = 318 Score = 52.4 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 29/194 (14%), Positives = 63/194 (32%), Gaps = 27/194 (13%) Query: 82 TGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKG 141 +G D LW K G+ + V+S +F+++ +V+ + + Sbjct: 81 SGSWDQTLRLW--DLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLA- 137 Query: 142 GAQWKLASQMQEVEEIVW---LKTHPTIAR-TFAFGATDGSVWCYQINEQDGSLEQLMSG 197 + +QE W ++ P + D +V + + + + + Sbjct: 138 ----ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL----ANCKLKNNH 189 Query: 198 FVHQQDCSMGEFINTDKGENTLELVT-CSLDSTIVAWNCFTGQQLFKITQAEIKGL---- 252 H ++NT L T DS + W+ G+ L+ + +I Sbjct: 190 HGHNG------YLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDIINALCFS 243 Query: 253 -EAPWISLSLAPET 265 W+ ++ P Sbjct: 244 PNRYWLCVAYGPSI 257 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 26/176 (14%), Positives = 54/176 (30%), Gaps = 15/176 (8%) Query: 64 HTDSVFAIGHHPNLP-LVCTGGGDNLAHLWTSHSQPPKFAGT----LTGYGESVISCSFT 118 H V I +P P + + D +W G L G+ + + Sbjct: 14 HNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLS 73 Query: 119 SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGS 178 S+G + ++ + + G + ++V + + + R G+ D + Sbjct: 74 SDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADN----RQIVSGSRDKT 129 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 + + + + H S F +V+C D T+ WN Sbjct: 130 IKLWNTL---AECKFTIQEDGHTDWVSCVRFSPNHSNP---IIVSCGWDRTVKVWN 179 Score = 36.2 bits (82), Expect = 0.024, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 38/100 (38%), Gaps = 8/100 (8%) Query: 45 DEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-------TSHSQ 97 D +AL D+++ Y +H D + A+ PN +C G + +W + Sbjct: 214 DSKALLWDLNDGKNLYTLEHNDIINALCFSPNRYWLCVAYGPS-IKIWDLACKKTVEELR 272 Query: 98 PPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHM 137 P + T +S +++++G L + V Sbjct: 273 PEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQ 312 Score = 35.5 bits (80), Expect = 0.041, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 30/78 (38%), Gaps = 3/78 (3%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT-- 118 F+ HT V ++ + + +G D LW + ++ KF G+ + V F+ Sbjct: 102 FEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLAEC-KFTIQEDGHTDWVSCVRFSPN 160 Query: 119 SEGGFLVTADMSGKVLVH 136 +V+ V V Sbjct: 161 HSNPIIVSCGWDRTVKVW 178 Score = 32.4 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 52/129 (40%), Gaps = 15/129 (11%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H + + P+ L +GG D+ A LW + K TL + + + + F+ + Sbjct: 192 HNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDG--KNLYTLE-HNDIINALCFSPNRYW 248 Query: 124 LVTA-DMSGKVLVHMGQKGGAQW--KLASQMQEVEE-----IVWLKTHPTIARTFAFGAT 175 L A S K+ +K + ++ S + ++ + W T +T G + Sbjct: 249 LCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAW----STDGQTLFAGYS 304 Query: 176 DGSVWCYQI 184 D ++ +Q+ Sbjct: 305 DNTIRVWQV 313 >5OQL-J nrPDB Length = 912 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 52/263 (19%), Positives = 95/263 (36%), Gaps = 46/263 (17%) Query: 64 HTDSVFA--IGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFA--GTLTGYGESVISCSF-- 117 H D V + + + + +G DN A LW + TG+ ESV + + Sbjct: 432 HEDIVMSLDVDWSGH--WIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPK 489 Query: 118 -----TSEGG---------FLVTADMSGKV----LVHMGQKGGAQWKLASQMQEVEEIVW 159 SE FL++ V + QKGG ++ ++I Sbjct: 490 VVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINA 549 Query: 160 LKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEF-------INT 212 L P + FA + D +V + + + ++ ++ G H++ F I Sbjct: 550 LDISPN-GKLFASASQDKTVKIWDV--EKLEVQGILRG--HKRGVWTVRFAPLNTPVIQG 604 Query: 213 DKGENTLE--LVTCSLDSTIVAWNC--FTGQQLFKITQAEIKGLEAPWISLSLAPETLTK 268 ++G + ++T S D TI WN +T + F+ + L+ W+ +S Sbjct: 605 EQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNV--LKVVWLHISRDDSITKT 662 Query: 269 GNSGVVACGSNNGLLAVINCNNG 291 A + L+ V + N G Sbjct: 663 KVQ--FASAGADTLVKVWDANTG 683 Score = 49.7 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 82/272 (30%), Gaps = 51/272 (18%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT----- 118 H + A+ PN L + D +W + G L G+ V + F Sbjct: 543 HDKDINALDISPNGKLFASASQDKTVKIWDVEKL--EVQGILRGHKRGVWTVRFAPLNTP 600 Query: 119 ---------SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQ----EVEEIVWLKTHPT 165 S G ++T + + + + + V ++VWL Sbjct: 601 VIQGEQGSVSGRGVVLTGSGDKTIKLWNL----SDYTCIRTFEGHSHNVLKVVWLHISRD 656 Query: 166 IART-----FAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLE 220 + T FA D V + N + H+ + N Sbjct: 657 DSITKTKVQFASAGADTLVKVWDANTGETECTL----DNHEDRLWT---LAVHSKTNI-- 707 Query: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNN 280 L + DS + W T + QA +K +E + + A + Sbjct: 708 LASAGSDSKVTFWRDTTAETQAAAAQAALKLVEQEQTLE-----------NYIHAGAYRD 756 Query: 281 GLLAVINCNNGGAILHLST--VIELKPEQDEL 310 ++ + N+ G +L+L T V P+ D L Sbjct: 757 AIVLALQLNHPGRLLNLFTNVVTTRNPDPDSL 788 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 37/169 (21%), Positives = 62/169 (36%), Gaps = 19/169 (11%) Query: 32 EGENDDDDEMMN--------DDEEALEVDMSNNSLT--YFD------KHTDSVFAIGHHP 75 +G+NDD DE+ + D D+ + T Y D H +V I + P Sbjct: 183 KGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP 242 Query: 76 NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLV 135 + +G D LW + GT E + S F +EG ++ +A SG + + Sbjct: 243 EQHALLSGSRDKTMTLWLWRDGI--WQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRI 300 Query: 136 HMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQI 184 K E E I+ + P + A D ++ Y++ Sbjct: 301 WDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQA-DFTLVLYRV 348 Score = 35.9 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 21/152 (13%), Positives = 45/152 (29%), Gaps = 24/152 (15%) Query: 102 AGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQ----MQEVEEI 157 L G+ + V+S G ++ + + + + ++ V + Sbjct: 426 VALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAV 485 Query: 158 VWLKTHP---TIA---------RTFAFGATDGSVW---CYQINEQDGSLEQLMSGFVHQQ 202 K P + A G+ D V + ++ G L + H + Sbjct: 486 ALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDK 545 Query: 203 DCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 D + + K + S D T+ W+ Sbjct: 546 DINALDISPNGKL-----FASASQDKTVKIWD 572 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 28/194 (14%), Positives = 63/194 (32%), Gaps = 27/194 (13%) Query: 100 KFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHM----GQKGGAQWKLASQMQEVE 155 K + G GE + + + T G L+ S + ++ + L + Sbjct: 52 KRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHA 111 Query: 156 EIVWLKTHPTIARTFAFGATDGSVWCYQI---------------------NEQDGSLEQL 194 V + + A GA DG++ + I E + E Sbjct: 112 TPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQ 171 Query: 195 MSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCF--TGQQLFKITQAEIKGL 252 S ++ G+ + D+ + L + D I ++ + T ++ + + + Sbjct: 172 SSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAH 231 Query: 253 EAPWISLSLAPETL 266 E+ ++ +PE Sbjct: 232 ESNVQCIAYSPEQH 245 Score = 29.3 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 7/32 (21%), Positives = 14/32 (43%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW 92 D H D ++ + H ++ + G D+ W Sbjct: 689 LDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 >5XYI-g nrPDB Length = 335 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 23/138 (16%), Positives = 54/138 (39%), Gaps = 12/138 (8%) Query: 98 PPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKL-ASQMQEVEE 156 P+ T G+ ++ S +E +LV+A LV + QW +++ Sbjct: 24 APR--ATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNH 81 Query: 157 IVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGE 216 V + A + D ++ + ++ + + ++L G H++D F ++ Sbjct: 82 FVSDVSLSRDASHLLTSSWDSTLRLWDLSTR--TTKKLFLG--HKKDVLGVTFSPCNR-- 135 Query: 217 NTLELVTCSLDSTIVAWN 234 +++ D+ + WN Sbjct: 136 ---RIISVGRDNQVKIWN 150 >3F3P-A nrPDB Length = 351 Score = 50.9 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 50/283 (17%), Positives = 91/283 (32%), Gaps = 48/283 (16%) Query: 106 TGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQ----EVEEIVWLK 161 +G+ + V + G + T + V K + W+L+ + + I W Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 162 THPTIARTFAFGATDGSVWCYQINEQDGSLE-----QLMSGFVHQQDCSMGEFINTDKG- 215 P R A + D +V ++ + +L + + +F G Sbjct: 68 --PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 125 Query: 216 -------ENTLELVTCSLDSTIVAWNCFTGQQLFKITQAE--IKGLEAPWISLSLAPETL 266 + L L S + +W + ++ I A W +PE L Sbjct: 126 KLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKL 185 Query: 267 TKG--NSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSK-- 322 ++ +G LH++ + P L I SISW+ Sbjct: 186 AVSALEQAIIYQRGKDGK------------LHVAAKL---PGHKSL---IRSISWAPSIG 227 Query: 323 --FSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKL-MFDN 362 + L+A G G I ++ + E+S+T MFDN Sbjct: 228 RWYQLIATGCKDGRIRIFKIT--EKLSPLASEESLTNSNMFDN 268 Score = 37.8 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 39/85 (45%), Gaps = 5/85 (5%) Query: 26 DVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGG 85 DV +D +G +D + E + + L+V++ L+ D H V+++ + ++ + G Sbjct: 271 DVDMDAQGRSDSNTEEKAELQSNLQVEL----LSEHDDHNGEVWSVSWNLTGTILSSAGD 326 Query: 86 DNLAHLW-TSHSQPPKFAGTLTGYG 109 D LW ++S K +T Sbjct: 327 DGKVRLWKATYSNEFKCMSVITAQQ 351 Score = 34.3 bits (77), Expect = 0.097, Method: Composition-based stats. Identities = 24/151 (15%), Positives = 47/151 (31%), Gaps = 31/151 (20%) Query: 64 HTDSVFAIGHHPNL----PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS 119 H + +I P++ L+ TG D ++ + A ES+ T+ Sbjct: 213 HKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS-----EESL-----TN 262 Query: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQ------------EVEEIVWLKTHPTIA 167 F +AD+ + +L S +Q EV + W T Sbjct: 263 SNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLT----G 318 Query: 168 RTFAFGATDGSVWCYQ-INEQDGSLEQLMSG 197 + DG V ++ + +++ Sbjct: 319 TILSSAGDDGKVRLWKATYSNEFKCMSVITA 349 >5K1B-B nrPDB Length = 677 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 29/184 (15%), Positives = 64/184 (34%), Gaps = 18/184 (9%) Query: 62 DKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEG 121 + HTD V I N + + D +W +H TL + + V + ++ + Sbjct: 72 EHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGF--CMSTLRTHKDYVKALAYAKDK 129 Query: 122 GFLVTADMSGKVLVHMGQ-----KGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATD 176 + +A + ++ + S + ++ ++ + G+T+ Sbjct: 130 ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTE 189 Query: 177 GSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCF 236 + + + +LM H + +N D + ++ S D TI W+ Sbjct: 190 KVLRVW----DPRTCAKLMKLKGHTDNV-KALLLNRDGTQ----CLSGSSDGTIRLWS-- 238 Query: 237 TGQQ 240 GQQ Sbjct: 239 LGQQ 242 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 27/150 (18%), Positives = 53/150 (35%), Gaps = 15/150 (10%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLW-------TSHSQPPKFAGTLTGYGESVISCS 116 H D V A+ + + LV + G D LW + S +L+G +S+ S + Sbjct: 116 HKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLA 175 Query: 117 FTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATD 176 G +V+ + V + KL V+ ++ + G++D Sbjct: 176 MNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNR----DGTQCLSGSSD 231 Query: 177 GSVWCYQINEQDGSLEQLMSGFVHQQDCSM 206 G++ + + +Q VH + Sbjct: 232 GTIRLWSLGQQ--RCIATYR--VHDEGVWA 257 Score = 34.3 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 33/79 (41%), Gaps = 7/79 (8%) Query: 160 LKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTL 219 L+ P + R F G D + + +N+ ++ H D + + + G+ Sbjct: 36 LQLDPALNRLFTAGR-DSIIRIWSVNQHKQD--PYIASMEHHTD-WVNDIVLCCNGKT-- 89 Query: 220 ELVTCSLDSTIVAWNCFTG 238 L++ S D+T+ WN G Sbjct: 90 -LISASSDTTVKVWNAHKG 107 >4XFV-A nrPDB Length = 792 Score = 50.5 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 29/134 (21%), Positives = 46/134 (34%), Gaps = 14/134 (10%) Query: 79 LVCTGGGDNLAHLWTSHSQPPK-FAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHM 137 +V G G LW K TL G+ V F + F+V+A V + Sbjct: 33 IVAFGAG-KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 91 Query: 138 -GQKGGAQWKLASQMQEV-EEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLM 195 + +Q + IV L P+ + G DG++ ++ N Q+ Sbjct: 92 FTDYS--HLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEF---- 142 Query: 196 SGFVHQQDCSMGEF 209 G H+ G F Sbjct: 143 -GLAHEFTIKKGFF 155 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 39/250 (15%), Positives = 74/250 (29%), Gaps = 78/250 (31%) Query: 61 FDKHTDSVFAIGHH----PNLPLVCTGGGDNLAHLWT---------SHSQPPK------- 100 + H D V ++ P L+C+G D LW S K Sbjct: 202 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNK 261 Query: 101 ---------------FAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQW 145 F + G+ + + S + L+ A ++V + W Sbjct: 262 QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIW 321 Query: 146 KLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCS 205 + ++ E+ + + A G++ G S F H++ Sbjct: 322 VCSLRLGEMS---------SKGASTATGSSGGF----------WSCLW----FTHERM-- 356 Query: 206 MGEFINTDKGENTLELVTCSL---------------DSTIVAWNCFTGQQLFKITQAEIK 250 +F T+ + + D T +AW+ +G+ L + + Sbjct: 357 --DFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSP-SGEYLLATSLDQTT 413 Query: 251 GLEAPWISLS 260 L APWI + Sbjct: 414 RLFAPWIYDA 423 Score = 31.2 bits (69), Expect = 0.95, Method: Composition-based stats. Identities = 15/92 (16%), Positives = 33/92 (35%), Gaps = 6/92 (6%) Query: 108 YGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVE-EIVW-LKTHPT 165 + ++ F+ +G FL++ K + ++L + ++ I+W P Sbjct: 609 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 668 Query: 166 I-ARTFAFGATDGSVWCY---QINEQDGSLEQ 193 F + D +V + + D LE Sbjct: 669 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEA 700 >6QDV-o nrPDB Length = 513 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 79/232 (34%), Gaps = 31/232 (13%) Query: 64 HTDSVFAIGHHP---NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 HT V A+ P +L L C D LW + + + T G+ ++V F + Sbjct: 221 HTKGVSAVRLFPLSGHLLLSC--SMDCKIKLWEVYGER-RCLRTFIGHSKAVRDICFNTA 277 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIAR--TFAFGATDGS 178 G ++A + + + G + S+ + +K +P + F G +D Sbjct: 278 GTQFLSAAYDRYLKLWDTETG----QCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKK 333 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 + + I + G + Q H + F++ ++ V+ S D ++ W Sbjct: 334 IVQWDI--RSGEIVQEYD--RHLGAVNTIVFVDENR-----RFVSTSDDKSLRVWEWDIP 384 Query: 239 QQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNN 290 I + + P N +AC S + + + N Sbjct: 385 VDFKYIAEPSMHS----------MPAVTLSPNGKWLACQSMDNQILIFGAQN 426 >5YZG-W nrPDB Length = 579 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 79/232 (34%), Gaps = 31/232 (13%) Query: 64 HTDSVFAIGHHP---NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 HT V A+ P +L L C D LW + + + T G+ ++V F + Sbjct: 287 HTKGVSAVRLFPLSGHLLLSC--SMDCKIKLWEVYGER-RCLRTFIGHSKAVRDICFNTA 343 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIAR--TFAFGATDGS 178 G ++A + + + G + S+ + +K +P + F G +D Sbjct: 344 GTQFLSAAYDRYLKLWDTETG----QCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKK 399 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 + + I + G + Q H + F++ ++ V+ S D ++ W Sbjct: 400 IVQWDI--RSGEIVQEYD--RHLGAVNTIVFVDENR-----RFVSTSDDKSLRVWEWDIP 450 Query: 239 QQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNN 290 I + + P N +AC S + + + N Sbjct: 451 VDFKYIAEPSMHS----------MPAVTLSPNGKWLACQSMDNQILIFGAQN 492 >5WYK-BB nrPDB Length = 943 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 73/195 (37%), Gaps = 27/195 (13%) Query: 12 EVEQEIVPTVEVEQDVPVDIEGENDDDDEMMND--------DEEALEVDMSNNSLTYF-- 61 +VE +VP + + +PV ++ +D E+ +D D+ L + + +N++ F Sbjct: 503 KVENSLVPGTK-NKFLPV-LKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFL 560 Query: 62 DKHTDSVFAIGHHPNLPLVCTG-GGDNLAHLWTSHSQPPKFAGT--------LTGYGESV 112 D + GH LP++ D+ + +S + K G L + +S+ Sbjct: 561 DSMKFYLSLYGHK--LPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSI 618 Query: 113 ISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAF 172 ++ F + + V G +++ ++ + VW T Sbjct: 619 MNVKFLPQSHNFFSCSKDAVVKYWD----GEKFECIQKLYAHQSEVWALAVATDGGFVVS 674 Query: 173 GATDGSVWCYQINEQ 187 + D S+ ++ E Sbjct: 675 SSHDHSIRIWEETED 689 Score = 41.6 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 54/176 (30%), Gaps = 28/176 (15%) Query: 59 TYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT 118 TY + H D L+ G D + +W S+ G+ ++ F Sbjct: 83 TYLEAHKD----------TDLLAVGYADGVIKVWDLMSKT--VLLNFNGHKAAITLLQFD 130 Query: 119 SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGS 178 G L++ ++V +KL S + W + + DG Sbjct: 131 GTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITG-FWCQGE----DWLISTSKDGM 185 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 + + + + + H +C G + D L+T DS + W Sbjct: 186 IKLWDLKTH--QCIE--THIAHTGECW-GLAVKDDL------LITTGTDSQVKIWK 230 Score = 33.9 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 80/234 (34%), Gaps = 35/234 (14%) Query: 29 VDIEGENDDDDEMMNDDEEALEVDMSNNSLTYFD-KHTDSVFAI--------GHHPNLPL 79 ++++G+ D + D+ L SN SL ++ K + P L Sbjct: 385 IELQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKTHKCIRTFECGYALTCKFLPGGLL 444 Query: 80 VCTGGGDNLAHLWTSHSQPPKFAGTLT-GYGESVISCSFTSEGGFLVTADMSGKVLVHMG 138 V G + L+ S T+ + ++ S TS+G LVT V Sbjct: 445 VILGTRNGELQLFDLASSS--LLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDF 502 Query: 139 QKG-----GAQWKLASQ--------MQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQIN 185 + G + K ++ ++I+ ++ P R A D +V + ++ Sbjct: 503 KVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDD-RYLAISLLDNTVKVFFLD 561 Query: 186 EQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQ 239 S++ +S + H+ + K ++T S D I W G Sbjct: 562 ----SMKFYLSLYGHKLPVLSIDISFDSKM-----IITSSADKNIKIWGLDFGD 606 Score = 32.8 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 32/79 (40%), Gaps = 10/79 (12%) Query: 156 EIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKG 215 E +L+ H A G DG + + S L++ H+ ++ +F T Sbjct: 81 ECTYLEAH-KDTDLLAVGYADGVIKVW----DLMSKTVLLNFNGHKAAITLLQFDGTGT- 134 Query: 216 ENTLELVTCSLDSTIVAWN 234 L++ S DS I+ W+ Sbjct: 135 ----RLISGSKDSNIIVWD 149 >5Y88-O nrPDB Length = 451 Score = 49.3 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 30/184 (16%), Positives = 62/184 (33%), Gaps = 16/184 (8%) Query: 64 HTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGG 122 H V + P + TG D +W K TL G+ +V + + Sbjct: 138 HLGWVRCVAIDPVDNEWFITGSNDTTMKVW--DLATGKLKTTLAGHVMTVRDVAVSDRHP 195 Query: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 +L + V +K + V + HPT+ A D + + Sbjct: 196 YLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTV---SIHPTL-DLIATAGRDSVIKLW 251 Query: 183 QINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLF 242 + + +++ H+ + + D ++V+ S D+T+ W+ G+ + Sbjct: 252 DMRTR----IPVITLVGHKGPINQVQCTPVDP-----QVVSSSTDATVRLWDVVAGKTMK 302 Query: 243 KITQ 246 +T Sbjct: 303 VLTH 306 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 41/212 (19%), Positives = 70/212 (33%), Gaps = 48/212 (22%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H V + HP L L+ T G D++ LW ++ P TL G+ + T Sbjct: 223 HLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVI--TLVGHKGPINQVQCTPVDPQ 280 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY- 182 +V++ V + G L + V HP + A TD + + Sbjct: 281 VVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRAT---ALHPKE-FSVASACTDD-IRSWG 335 Query: 183 ---------------------QINEQD----GSLEQLMSGFVHQ-----QDCSMGEFINT 212 IN+ D G ++S + ++ Q + E + + Sbjct: 336 LAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGS 395 Query: 213 DKGENT----------LELVTCSLDSTIVAWN 234 +GE + L L+T D +I W Sbjct: 396 LEGERSVLCSTFDKTGLRLITGEADKSIKIWK 427 Score = 30.1 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 23/141 (16%), Positives = 45/141 (31%), Gaps = 13/141 (9%) Query: 53 MSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESV 112 ++ ++ H SV A HP V + D++ + LT + Sbjct: 296 VAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGS------LLTNFESEK 349 Query: 113 ISC--SFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEV-----EEIVWLKTHPT 165 + + ++ A VL K G +++ + + V E V T Sbjct: 350 TGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDK 409 Query: 166 IARTFAFGATDGSVWCYQINE 186 G D S+ ++ +E Sbjct: 410 TGLRLITGEADKSIKIWKQDE 430 >2PM9-A nrPDB Length = 416 Score = 48.6 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 37/207 (17%), Positives = 78/207 (37%), Gaps = 21/207 (10%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNL-PLVCTGGGDNLAHLWTSH---SQPPKFAGTL 105 E + + NS+ F H+ SV + + ++ +GG + +W + P + Sbjct: 98 EANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLT 157 Query: 106 TGYG----ESVISCSFTSE-GGFLVTADMSGKVLVHMGQKGGAQWKLA------SQMQEV 154 G + VIS ++ +A S + + L+ Q++ Sbjct: 158 PGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQL 217 Query: 155 EEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDK 214 + W + T T D S+ + + + L+ L G HQ+ ++ + D+ Sbjct: 218 SVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQG--HQKGILSLDWCHQDE 275 Query: 215 GENTLELVTCSLDSTIVAWNCFTGQQL 241 L++ D+T++ WN + +QL Sbjct: 276 H----LLLSSGRDNTVLLWNPESAEQL 298 Score = 31.6 bits (70), Expect = 0.76, Method: Composition-based stats. Identities = 16/117 (13%), Positives = 44/117 (37%), Gaps = 10/117 (8%) Query: 76 NLPLVCTGGGDN-LAHLWTSHSQPPKF--AGTLTGYGESVISCSFTS-EGGFLVTADMSG 131 + + G DN L++++ + + SV + F + + L + +G Sbjct: 77 HNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNG 136 Query: 132 KVLVHMGQ---KGGAQWKLAS---QMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 ++ + + + + + M V+E++ L + ++A FA + + Sbjct: 137 EIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIW 193 >3JAP-g nrPDB Length = 326 Score = 48.6 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 33/244 (13%), Positives = 83/244 (34%), Gaps = 26/244 (10%) Query: 67 SVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTL---TGYGESVISCSFTSEGGF 123 S+ PN L+ +G D W +F + G+ V +++G + Sbjct: 23 SLSTSAAQPN--LLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNY 80 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 V+A + + G ++ + +V + + + D ++ + Sbjct: 81 AVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDAN----SSKIISASRDKTIRVWN 136 Query: 184 INEQDGSLEQLMSG---FVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ 240 G ++ G +V + + + + + + V+ +D + +W+ + Sbjct: 137 TV---GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWS--LNED 191 Query: 241 LFKITQAEIKGLEAPWISLSLAPETLTKGNSG-VVACGSNNGLLAVINCNNGGAILHLST 299 ++I EA +I + + G + A +G + V N + A ++ Sbjct: 192 SYRI--------EADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA 243 Query: 300 VIEL 303 E+ Sbjct: 244 KDEV 247 Score = 41.6 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 25/160 (15%), Positives = 53/160 (33%), Gaps = 11/160 (6%) Query: 82 TGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKG 141 + G D + W+ + + G+ + + +G +A G++ V + Sbjct: 176 SAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHK 235 Query: 142 GAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ--DGSLEQLMSGFV 199 A ++ +E+ L P+ R + AT + Y + + L+ +G+ Sbjct: 236 SAFMNFDAK----DEVFALAFSPS--RFWLTAATASGIKIYDLENEVLIDELKPEFAGYT 289 Query: 200 HQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQ 239 QD + G+ D+ I W T Sbjct: 290 KAQDPHAVSLAWSADGQTLF---AGYTDNVIRVWQVMTAN 326 >5A31-R nrPDB Length = 386 Score = 48.2 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 31/190 (16%), Positives = 68/190 (35%), Gaps = 17/190 (8%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYG 109 +V M + + HT V + + + +GG DN+ H++ S+ P T + Sbjct: 199 DVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPIL--TFDEHK 256 Query: 110 ESVISCSFT-SEGGFLVT--ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTI 166 +V + +++ + G L T ++ + + S Q + +VW K + Sbjct: 257 AAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ-ICNMVWSKNTNEL 315 Query: 167 ARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSL 226 + + + ++W + ++ G H N +V+ + Sbjct: 316 VTSHGYSKYNLTLWDCNSMDP----IAILKG--HSFRVLHLTLSNDGTT-----VVSGAG 364 Query: 227 DSTIVAWNCF 236 D T+ W F Sbjct: 365 DETLRYWKLF 374 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 59/152 (38%), Gaps = 18/152 (11%) Query: 43 NDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNL-PLVCTGGG--DNLAHLWTSHSQPP 99 ND+ + S + + FD+H +V A+ P+ ++ TGGG D +W ++ Sbjct: 234 NDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSI- 292 Query: 100 KFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKL-----ASQMQEV 154 K + +G + + ++ LVT+ K + + W + ++ Sbjct: 293 KMSDIDSG--SQICNMVWSKNTNELVTSHGYSKYNLTL-------WDCNSMDPIAILKGH 343 Query: 155 EEIVWLKTHPTIARTFAFGATDGSVWCYQINE 186 V T T GA D ++ +++ + Sbjct: 344 SFRVLHLTLSNDGTTVVSGAGDETLRYWKLFD 375 >4BH6-A nrPDB Length = 308 Score = 48.2 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 31/190 (16%), Positives = 68/190 (35%), Gaps = 17/190 (8%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYG 109 +V M + + HT V + + + +GG DN+ H++ S+ P T + Sbjct: 130 DVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPIL--TFDEHK 187 Query: 110 ESVISCSFT-SEGGFLVT--ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTI 166 +V + +++ + G L T ++ + + S Q + +VW K + Sbjct: 188 AAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ-ICNMVWSKNTNEL 246 Query: 167 ARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSL 226 + + + ++W + ++ G H N +V+ + Sbjct: 247 VTSHGYSKYNLTLWDCNSMDP----IAILKG--HSFRVLHLTLSNDGTT-----VVSGAG 295 Query: 227 DSTIVAWNCF 236 D T+ W F Sbjct: 296 DETLRYWKLF 305 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 28/153 (18%), Positives = 60/153 (39%), Gaps = 18/153 (11%) Query: 43 NDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNL-PLVCTGGG--DNLAHLWTSHSQPP 99 ND+ + S + + FD+H +V A+ P+ ++ TGGG D +W ++ Sbjct: 165 NDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSI- 223 Query: 100 KFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKL-----ASQMQEV 154 K + +G + + ++ LVT+ K + + W + ++ Sbjct: 224 KMSDIDSG--SQICNMVWSKNTNELVTSHGYSKYNLTL-------WDCNSMDPIAILKGH 274 Query: 155 EEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 V T T GA D ++ +++ ++ Sbjct: 275 SFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDK 307 >5FVM-C nrPDB Length = 303 Score = 47.8 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 36/191 (18%), Positives = 67/191 (35%), Gaps = 13/191 (6%) Query: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGES 111 D+ + S+ KH V + HPN + + D +W + LT + Sbjct: 103 DVRSPSVQRNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDLGEN--QCTNQLTPEDNT 160 Query: 112 -VISCSFTSEGGFLVTADMSGKVLVHMG--QKGGAQWKLASQMQEVEEIVWLKTHPTIAR 168 + S S S+G LV + G V + + ++ + + + + Sbjct: 161 PLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVK 220 Query: 169 TFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDS 228 A + D + + I E + LE + G HQ+ F ++ LVT D Sbjct: 221 NLATCSADHTARVWNI-EDNYQLETTLDG--HQRWVWDCAF-----SADSAYLVTACSDH 272 Query: 229 TIVAWNCFTGQ 239 + W+ T + Sbjct: 273 YVRLWDLSTSE 283 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 32/204 (15%), Positives = 65/204 (31%), Gaps = 18/204 (8%) Query: 56 NSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISC 115 N ++ F+ H +V +I + + D +W S + V Sbjct: 66 NPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPS---VQRNYKHNAPVNEV 122 Query: 116 SFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQ-EVEEIVWLKTHPTIARTFAFGA 174 + G L++ D G + + + + +Q+ E + + + G Sbjct: 123 AIHPNQGELISCDQDGNIRIWDLGEN----QCTNQLTPEDNTPLQSLSVASDGSMLVAGN 178 Query: 175 TDGSVWCYQI-NEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAW 233 G+ + +++ + D S + ++ F ++ D L TCS D T W Sbjct: 179 NKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSAD----VKNLATCSADHTARVW 234 Query: 234 NCFTGQQLFKITQAEIKGLEAPWI 257 N QL W+ Sbjct: 235 NIEDNYQLETTL-----DGHQRWV 253 >3JB9-L nrPDB Length = 340 Score = 47.8 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 22/141 (15%), Positives = 53/141 (37%), Gaps = 12/141 (8%) Query: 52 DMSNNSLTYFDK-HTDSVFAIGHHPNLPLVCTGGGDNLAHLW------TSHSQPPKFAGT 104 D+ NN ++ K H D + ++ + + + DN ++ ++ Q F G Sbjct: 205 DLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGA 264 Query: 105 LTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 + G +++ +++ F+ V V G ++ L V + HP Sbjct: 265 IHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVW-SATGDLRYVLPGHEGSVNHV---DFHP 320 Query: 165 TIARTFAFGATDGSVWCYQIN 185 + + D +++ ++N Sbjct: 321 HQDIILSCSS-DRTIFLGELN 340 Score = 32.4 bits (72), Expect = 0.44, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 110/308 (35%), Gaps = 46/308 (14%) Query: 107 GYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTI 166 G+ V+ F G + + M ++L+ + + + + Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNY---GVLNGCKGAITDLQWSRD 104 Query: 167 ARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSL 226 +R ++D + + S +++ H + + + + L + S Sbjct: 105 SRVVYCSSSDTHLMSW----DAVSGQKIRKHKGHAGVVNALDVLKV----GSELLTSVSD 156 Query: 227 DSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVI 286 D T+ W+ + IK +E + ++A +G + G +G + + Sbjct: 157 DCTMKVWDSRSKD--------CIKTIEEKYPLTAVA--IAQQGTQVFI--GGIDGAIKIW 204 Query: 287 NCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYD----TSA 342 + N H S V LK +D I S++ S S + + + ++D SA Sbjct: 205 DLRNN----HCSHV--LKGHKD----IITSLAISKDGSSLLSNSMDNTVRIFDVKPFASA 254 Query: 343 WRVRHKFV-----LEDSVTKLMFDNDDLF--ASCINGKVYQFNARTGQEKFVCVGHNMGV 395 R F E ++ + + + F A + VY ++A TG ++V GH G Sbjct: 255 QRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSA-TGDLRYVLPGHE-GS 312 Query: 396 LDFILLHP 403 ++ + HP Sbjct: 313 VNHVDFHP 320 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 103/308 (33%), Gaps = 73/308 (23%) Query: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGES 111 D++ +L F HT V P+ +GG D LW + G L G + Sbjct: 38 DLNVPNLQMFG-HTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNY-GVLNGCKGA 95 Query: 112 VISCSFTSEGGFLVTADMSGKVLVHMGQKG---------------------GAQWKLASQ 150 + ++ + + + ++ G G++ L S Sbjct: 96 ITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSEL-LTSV 154 Query: 151 MQEVEEIVW-----------LKTHPTIARTFA-------FGATDGSVWCYQINEQDGSLE 192 + VW + +P A A G DG++ + + Sbjct: 155 SDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNN--HCS 212 Query: 193 QLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNC---FTGQQLFKITQAEI 249 ++ G +D I+ D L++ S+D+T+ ++ + Q+ +I + I Sbjct: 213 HVLKG---HKDIITSLAISKDGSS----LLSNSMDNTVRIFDVKPFASAQRQLQIFEGAI 265 Query: 250 KGLEAPWISLSLAPETLTKGNSGVVACGSNN---------GLLAVINCNNGGAILHLSTV 300 G E + ++ + NS V GS++ G L + + G++ H Sbjct: 266 HGQEHNLLGVAWSR------NSRFVGAGSSDKNVYVWSATGDLRYVLPGHEGSVNH---- 315 Query: 301 IELKPEQD 308 ++ P QD Sbjct: 316 VDFHPHQD 323 >4A11-B nrPDB Length = 408 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 33/189 (17%), Positives = 58/189 (30%), Gaps = 15/189 (7%) Query: 62 DKHTDSVFAIGHHPN-LPLVCTGGGDNLAHLWTSH--SQPPKFAGTLTGYGESVISCSFT 118 D H SV + +P+ + + D +W ++ F T Y + + Sbjct: 96 DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPV--S 153 Query: 119 SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGS 178 ++ + KV + + G L QE+ + W P A + D Sbjct: 154 TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS---PRYDYILATASADSR 210 Query: 179 VWCYQINEQDGSLEQL-MSGFVHQQDCSMGEFINTDKGENT------LELVTCSLDSTIV 231 V + + G L L Q + K L L+T D+ + Sbjct: 211 VKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMR 270 Query: 232 AWNCFTGQQ 240 WN G+ Sbjct: 271 LWNSSNGEN 279 Score = 28.5 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 11/79 (13%), Positives = 28/79 (35%), Gaps = 16/79 (20%) Query: 120 EGGFLVTADMSGKVLVHMGQKGGAQ--WKLASQMQ-----------EVEEIVWLKTHPTI 166 EG ++++ G ++++ + Q + + VE + W +P Sbjct: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW---YPHD 111 Query: 167 ARTFAFGATDGSVWCYQIN 185 F + D ++ + N Sbjct: 112 TGMFTSSSFDKTLKVWDTN 130 >2P9P-C nrPDB Length = 372 Score = 46.6 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 97/283 (34%), Gaps = 27/283 (9%) Query: 72 GHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSG 131 + + + ++ H++ L + V + + +VT Sbjct: 15 AWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVTCGTDR 74 Query: 132 KVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW-CYQINEQDGS 190 V + G WK + + + FA G+ + CY E D Sbjct: 75 NAYVWTLK--GRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQENDWW 132 Query: 191 LEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIK 250 + + H + ++ D N++ L S D ++ + I + E + Sbjct: 133 VCK------HIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAY-------IKEVEER 179 Query: 251 GLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDEL 310 PW S E + +CG +G+ N + + H STV ++ Sbjct: 180 PAPTPWGSKMPFGELM---FESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMA 236 Query: 311 DASIES-------ISWSSKFSLMAIGLVCGEILL-YDTSAWRV 345 A++ S +++ ++ SL+A G C +L YD++A ++ Sbjct: 237 VATLASETLPLLAVTFITESSLVAAGHDCFPVLFTYDSAAGKL 279 Score = 36.2 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 18/124 (14%), Positives = 39/124 (31%), Gaps = 2/124 (1%) Query: 63 KHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGG 122 +H V + P+ + T G D A++WT + K + + + Sbjct: 50 EHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEK 109 Query: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEE-IVWLKTHPTIARTFAFGATDGSVWC 181 S + + ++ W + + ++ L HP + A G+ D Sbjct: 110 KFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPN-SVLLAAGSCDFKCRI 168 Query: 182 YQIN 185 + Sbjct: 169 FSAY 172 >6G51-g nrPDB Length = 317 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 82/244 (33%), Gaps = 34/244 (13%) Query: 64 HTDSVFAIGHHPNLP-LVCTGGGDNLAHLW------TSHSQPPKFAGTLTGYGESVISCS 116 H V I P P ++ + D +W T++ P + L G+ V Sbjct: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR---ALRGHSHFVSDVV 70 Query: 117 FTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATD 176 +S+G F ++ G + + G + ++V + + + R G+ D Sbjct: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF----SSDNRQIVSGSRD 126 Query: 177 GSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCF 236 ++ + G + + H + S F +V+C D + WN Sbjct: 127 KTIKLWNTL---GVCKYTVQDESHSEWVSCVRFSPNSSNP---IIVSCGWDKLVKVWN-- 178 Query: 237 TGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILH 296 K G +++++P+ + A G +G + + N G H Sbjct: 179 LANCKLKTNHIGHTGYLN---TVTVSPD------GSLCASGGKDGQAMLWDLNEGK---H 226 Query: 297 LSTV 300 L T+ Sbjct: 227 LYTL 230 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 28/196 (14%), Positives = 63/196 (32%), Gaps = 31/196 (15%) Query: 82 TGGGDNLAHLW--TSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQ 139 +G D LW T+ + +F G+ + V+S +F+S+ +V+ + + Sbjct: 80 SGSWDGTLRLWDLTTGTTTRRFV----GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL 135 Query: 140 KGGAQWKLASQMQEVEEIVW---LKTHPTIAR-TFAFGATDGSVWCYQINEQDGSLEQLM 195 +Q+ W ++ P + D V + + + + Sbjct: 136 GV-----CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL----ANCKLKT 186 Query: 196 SGFVHQQDCSMGEFINTDKGENTLELV-TCSLDSTIVAWNCFTGQQLFKITQAEIKGL-- 252 + H ++NT L + D + W+ G+ L+ + +I Sbjct: 187 NHIGHTG------YLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240 Query: 253 ---EAPWISLSLAPET 265 W+ + P Sbjct: 241 FSPNRYWLCAATGPSI 256 Score = 35.5 bits (80), Expect = 0.043, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 45/140 (32%), Gaps = 12/140 (8%) Query: 52 DMSNNSLTY-FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGE 110 D++ + T F HT V ++ + + +G D LW + K+ + E Sbjct: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVC-KYTVQDESHSE 149 Query: 111 SVISCSFT--SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLK--THPTI 166 V F+ S +V+ V V + + +L T Sbjct: 150 WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA------NCKLKTNHIGHTGYLNTVTVSPD 203 Query: 167 ARTFAFGATDGSVWCYQINE 186 A G DG + +NE Sbjct: 204 GSLCASGGKDGQAMLWDLNE 223 >1NR0-A nrPDB Length = 611 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 33/156 (21%), Positives = 58/156 (37%), Gaps = 9/156 (5%) Query: 79 LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMG 138 V GG D+ H++ T+ + + S +F++ G FLV D S KV+ + Sbjct: 462 FVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQSRKVIPYSV 520 Query: 139 QKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGF 198 S ++ + P R A G+ D SV + +N+ ++ G Sbjct: 521 ANNFELAHTNSWTFHTAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKPSDHPI-IIKGA 578 Query: 199 VHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 + ++N +V+ DS I WN Sbjct: 579 HAMSSVNSVIWLNETT------IVSAGQDSNIKFWN 608 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 32/83 (38%), Gaps = 9/83 (10%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLT-------GYGESVI 113 F +HT V ++ ++P+ L + GGD L+ G + SV Sbjct: 186 FGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTK--TGVFEDDSLKNVAHSGSVF 243 Query: 114 SCSFTSEGGFLVTADMSGKVLVH 136 +++ +G + +A + + Sbjct: 244 GLTWSPDGTKIASASADKTIKIW 266 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 30/82 (36%), Gaps = 5/82 (6%) Query: 56 NSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYG-ESVIS 114 NS T+ HT V + P+ + TG DN +W + + SV S Sbjct: 530 NSWTF---HTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS 586 Query: 115 CSFTSEGGFLVTADMSGKVLVH 136 + +E +V+A + Sbjct: 587 VIWLNETT-IVSAGQDSNIKFW 607 Score = 37.0 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 38/204 (18%), Positives = 66/204 (32%), Gaps = 51/204 (25%) Query: 65 TDSVFAIGHHPNLPLVCTGGG--DNLAHLWTSHSQPPKFAGTLTGYGESVISC------- 115 +F + +L +V GG D+ + S P +V +C Sbjct: 378 KGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIY 437 Query: 116 -----------------SFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIV 158 + +++ F+ KV H+ + GA + EV+ IV Sbjct: 438 SHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKV--HVYKLSGAS------VSEVKTIV 489 Query: 159 WLKTHPTIARTFAFG-------ATDGSVWCYQIN-EQDGSLEQLMSGFVHQQDCSMGEFI 210 HP + AF ATD S + + L S H + + Sbjct: 490 ----HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWS 545 Query: 211 NTDKGENTLELVTCSLDSTIVAWN 234 + + L T SLD++++ WN Sbjct: 546 PDN-----VRLATGSLDNSVIVWN 564 Score = 34.3 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 48/304 (15%), Positives = 99/304 (32%), Gaps = 42/304 (13%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQM--QEVEEIVWLK 161 T + + G + + D+ G V + + K + V++I W Sbjct: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 Query: 162 THPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLEL 221 IA G V+ + +G+L + + +F K + Sbjct: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG------QARAMNSVDF----KPSRPFRI 163 Query: 222 VTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWI-SLSLAPETLTKGNSGVVACGSNN 280 ++ S D+T+ + + G ++ S+ P+ + A + Sbjct: 164 ISGSDDNTVAIF------EGPPFKFKSTFGEHTKFVHSVRYNPD------GSLFASTGGD 211 Query: 281 GLLAVINCNNGGAILHLSTVIELKPEQDEL-----DASIESISWSSKFSLMAIGLVCGEI 335 G + + N +G + V E D L S+ ++WS + +A I Sbjct: 212 GTIVLYNGVDGTK----TGVF----EDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTI 263 Query: 336 LLYDTSAWRVRHKFV----LEDSVTKLMFDNDDLFASCINGKVYQFNARTGQEKFVCVGH 391 +++ + +V +ED +++ L + NG + N G V GH Sbjct: 264 KIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGH 323 Query: 392 NMGV 395 N + Sbjct: 324 NKAI 327 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 39/271 (14%), Positives = 69/271 (25%), Gaps = 59/271 (21%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 + +H+ P+ +G +W + T+ + V S+ SE Sbjct: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 Query: 121 GGFLVTA----DMSGKVLVHMGQKG----------------------------------- 141 + + G V + Sbjct: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAI 174 Query: 142 --GAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFV 199 G +K S E + V + FA DG++ Y N DG+ + Sbjct: 175 FEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY--NGVDGTKTGVFEDDS 232 Query: 200 HQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAP---W 256 + G + ++ + S D TI WN T + I + W Sbjct: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 Query: 257 ISLSLAPETLTKGNSGVVACGSNNGLLAVIN 287 +L S NG + +N Sbjct: 293 TKQALV-------------SISANGFINFVN 310 >6N9G-C nrPDB Length = 353 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 42/198 (21%), Positives = 69/198 (34%), Gaps = 20/198 (10%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 TL G+G V+ + + +V++ GKV+V + + ++ Sbjct: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEH---AVTMPCTWVMACAYA 114 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFV--HQQDCSMGEFINTDKGENTLEL 221 P+ A G D Y + V H S F N+D +++ Sbjct: 115 PS-GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSD-----MQI 168 Query: 222 VTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNG 281 +T S D T W+ +GQ L G A + L LAP GN+ V G + Sbjct: 169 LTASGDGTCALWDVESGQLL-----QSFHGHGADVLCLDLAPS--ETGNTFV--SGGCDK 219 Query: 282 LLAVINCNNGGAILHLST 299 V + +G + T Sbjct: 220 KAMVWDMRSGQCVQAFET 237 Score = 37.8 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 34/207 (16%), Positives = 65/207 (31%), Gaps = 43/207 (20%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI--SCSFTSEG 121 HT+ + A + + T GD LW S + + G+G V+ + + G Sbjct: 152 HTNYLSACSFTNSDMQILTASGDGTCALWDVESG--QLLQSFHGHGADVLCLDLAPSETG 209 Query: 122 GFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWC 181 V+ K +V + G + + E V + FA G+ D + Sbjct: 210 NTFVSGGCDKKAMVWDMRSG----QCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRL 265 Query: 182 YQINEQ------------------DGSLE-QLMSGFVHQQDCSMGEFINTDKGE------ 216 Y + D SL +L+ + ++ + + + Sbjct: 266 YDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHE 325 Query: 217 ---NTLEL-------VTCSLDSTIVAW 233 +TL + + S D T+ W Sbjct: 326 NRVSTLRVSPDGTAFCSGSWDHTLRVW 352 >3C9C-A nrPDB Length = 432 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 25/161 (15%), Positives = 54/161 (33%), Gaps = 18/161 (11%) Query: 44 DDEEALEVDMSNNSLT----YFDKHTDSVFAIGHHPNLP-LVCTGGGDNLAHLWTSHSQP 98 DD++ + D NN+ + D HT V + +P ++ TG D LW + Sbjct: 254 DDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 313 Query: 99 PKFAGTLTGYGESVISCSFT-SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEI 157 K + + + ++ L ++ ++ V K G + E+ Sbjct: 314 LKLHS-FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPEL 372 Query: 158 VWL-----------KTHPTIARTFAFGATDGSVWCYQINEQ 187 +++ +P + D + +Q+ E Sbjct: 373 LFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 413 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 28/167 (16%), Positives = 57/167 (34%), Gaps = 22/167 (13%) Query: 82 TGGGDNLAHLWTSHSQPPKFAGT------LTGYGESVISCSFT-SEGGFLVTADMSGKVL 134 T D L +T H P+ +G L G+ + S+ + G+L++A + Sbjct: 150 TPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTIC 209 Query: 135 VHMGQKGGAQWKLASQ-------MQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 + + ++ VE++ W H + F A D + + Sbjct: 210 LWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES---LFGSVADDQKLMIW-DTRN 265 Query: 188 DGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 + + + + H + + F + L T S D T+ W+ Sbjct: 266 NNTSKPSHTVDAHTAEVNCLSFNPYSE----FILATGSADKTVALWD 308 >5WLC-LW nrPDB Length = 554 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 28/153 (18%), Positives = 51/153 (33%), Gaps = 14/153 (9%) Query: 70 AIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADM 129 A+ +P ++ G + LW S S P L+ G V S + G ++ T Sbjct: 237 AMAQNPWNAVMHLGHSNGTVSLW-SPSMPEPLVKLLSARG-PVNSIAIDRSGYYMATTGA 294 Query: 130 SGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIART-FAFGATDGSVWCYQI---- 184 + + + Q+ VE + T+ +I+ T + V ++ Sbjct: 295 DRSMKIWDIRN-------FKQLHSVESLPTPGTNVSISDTGLLALSRGPHVTLWKDALKL 347 Query: 185 NEQDGSLEQLMSGFVHQQDCSMGEFINTDKGEN 217 + M G H+ M +K EN Sbjct: 348 SGDSKPCFGSMGGNPHRNTPYMSHLFAGNKVEN 380 >6Q8F-A nrPDB Length = 514 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 89/253 (35%), Gaps = 16/253 (6%) Query: 31 IEGENDDDDEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAH 90 + G D E+ N + D+ + F D+V + + ++ TG D Sbjct: 231 VTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIK 290 Query: 91 LWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQ 150 +W + + V SF+ + +++A + +H G K G K + Sbjct: 291 VW-KIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIH-GLKSG---KTLKE 345 Query: 151 MQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFI 210 + V T ++DG+V + + + S G D ++ I Sbjct: 346 FRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVI 405 Query: 211 NTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGN 270 K V C+ +T+V N GQ + + + +G ++ +L+P +G Sbjct: 406 LLPKNPEHF--VVCNRSNTVVIMN-MQGQIVRSFSSGKREG--GDFVCCALSP----RGE 456 Query: 271 SGVVACGSNNGLL 283 + C + +L Sbjct: 457 --WIYCVGEDFVL 467 Score = 45.1 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 35/183 (19%), Positives = 66/183 (36%), Gaps = 19/183 (10%) Query: 70 AIGHHPNLPLVCTG------GGDNLAHLWTSHSQPPKFAGTLT-GYGESVISCSFTSEGG 122 A+ + L+ G G P + + + G V F+ +G Sbjct: 169 ALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQ 228 Query: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQE----VEEIVWLKTHPTIARTFAFGATDGS 178 +LVT + G + V G + L Q Q+ +++ V A GA DG Sbjct: 229 YLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGK 288 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 + ++I Q G + H + + F +++ ++++ S D TI +G Sbjct: 289 IKVWKI--QSGQCLRRFE-RAHSKGVTCLSF-----SKDSSQILSASFDQTIRIHGLKSG 340 Query: 239 QQL 241 + L Sbjct: 341 KTL 343 Score = 34.3 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 12/29 (41%), Positives = 14/29 (48%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLW 92 H V I HHP+ L+ T D L LW Sbjct: 484 HEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 Score = 29.3 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 42/184 (22%), Positives = 74/184 (40%), Gaps = 27/184 (14%) Query: 221 LVTCSLDSTIVAWNCFTG---QQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACG 277 LVT S+D I WN TG + L Q ++ + + + +T ++A G Sbjct: 230 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTE------MLATG 283 Query: 278 SNNGLLAVINCNNGGAI-----LHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVC 332 + +G + V +G + H V L +D S + +S S ++ GL Sbjct: 284 AQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKD----SSQILSASFDQTIRIHGLKS 339 Query: 333 GEILLYDTSAWRVRHKFVLEDSVTKLMFDNDDLFASCINGKVYQFNARTGQ--EKFVCVG 390 G+ L +R FV E + T+ D + ++ +G V +N +T + F +G Sbjct: 340 GKTL----KEFRGHSSFVNEATFTQ---DGHYIISASSDGTVKIWNMKTTECSNTFKSLG 392 Query: 391 HNMG 394 G Sbjct: 393 STAG 396 >5OQL-d nrPDB Length = 446 Score = 45.9 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 47/123 (38%), Gaps = 11/123 (8%) Query: 64 HTDSVFAIGHHPN-LPLVCTGGGDNLAHLW---TSHSQPPKFAGTLTGYGESVISCSFTS 119 H V+++ N L + +G GD + +W T + + A + V +FT+ Sbjct: 65 HVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAA----HNNIVKGLTFTN 120 Query: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 + L++ G + + + + QE L H + A TFA + G + Sbjct: 121 DKK-LLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRS-ANTFAASSGQGCI 177 Query: 180 WCY 182 + Sbjct: 178 RIW 180 Score = 33.5 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 30/174 (17%), Positives = 56/174 (32%), Gaps = 21/174 (12%) Query: 70 AIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADM 129 ++ H + G +W A + +++ F V + Sbjct: 158 SLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQ-----VETSV 212 Query: 130 SGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH-----PTIARTFAFGATDGSVWCYQI 184 G V + + L + M ++ ++ + P A A + D +++ + Sbjct: 213 IGSV---ATDRSIILFDLRTNMPVIKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDA 269 Query: 185 NEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 D +L + G H EF T + ELV+ S D TI W G Sbjct: 270 RNFDKAL-NIQKG--HVAAVMDVEFSPTGE-----ELVSGSYDRTIRLWRRDAG 315 >6GMH-W nrPDB Length = 305 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 39/227 (17%), Positives = 83/227 (36%), Gaps = 30/227 (13%) Query: 64 HTDSVFAIGH----HPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS 119 H D+++++ N V TG D+L +W + +L G+ V+S + Sbjct: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74 Query: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179 ++ + + + + G K + W ++ A G G V Sbjct: 75 TLPIAASSSLDAHIRLWDLENG----KQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKV 130 Query: 180 WCYQINEQDGSLEQLMSGFVHQQDCSMGEFI-NTDKGENTLELVTCSLDSTIVAWNCFTG 238 + + SG + G+FI + + L + ++D I ++ TG Sbjct: 131 NIF----------GVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180 Query: 239 QQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAV 285 + L ++G P SL+ +P+ S ++ S++G + + Sbjct: 181 KLLHT-----LEGHAMPIRSLTFSPD------SQLLVTASDDGYIKI 216 Score = 45.1 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 34/177 (19%), Positives = 68/177 (38%), Gaps = 19/177 (10%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 D + +I + P+ + +G D + +++ K TL G+ + S +F+ + Sbjct: 144 LDTRGKFILSIAYSPDGKYLASGAIDGIINIF--DIATGKLLHTLEGHAMPIRSLTFSPD 201 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLK--THPTIARTFAFGATDGS 178 LVTA G + ++ Q L+ V + + TH F ++D S Sbjct: 202 SQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH------FVSSSSDKS 255 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNC 235 V + G+ + + F HQ ++ N ++V+ D I ++C Sbjct: 256 VKVW----DVGTRTCVHTFFDHQDQVWGVKYNG-----NGSKIVSVGDDQEIHIYDC 303 >3CFV-B nrPDB Length = 414 Score = 45.5 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 25/161 (15%), Positives = 55/161 (34%), Gaps = 18/161 (11%) Query: 44 DDEEALEVDMSNNSLT----YFDKHTDSVFAIGHHPNLP-LVCTGGGDNLAHLWTSHSQP 98 DD++ + D +N+ + D HT V + +P ++ TG D LW + Sbjct: 250 DDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 309 Query: 99 PKFAGTLTGYGESVISCSFT-SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEI 157 K T + + + ++ L ++ ++ V K G + E+ Sbjct: 310 LKL-HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPEL 368 Query: 158 VWL-----------KTHPTIARTFAFGATDGSVWCYQINEQ 187 +++ +P + D + +Q+ E Sbjct: 369 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAEN 409 Score = 44.7 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 33/180 (18%), Positives = 60/180 (33%), Gaps = 22/180 (12%) Query: 69 FAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGT------LTGYGESVISCSF-TSEG 121 + +P++ T D L +T H P +G L G+ + S+ ++ Sbjct: 133 RYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLS 192 Query: 122 GFLVTADMSGKVLVHMGQKGGAQWKLASQMQ-------EVEEIVWLKTHPTIARTFAFGA 174 G L++A V + G + K+ VE++ W H + F A Sbjct: 193 GHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES---LFGSVA 249 Query: 175 TDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 D + + S + H + + F + L T S D T+ W+ Sbjct: 250 DDQKLMIWDTRSNTTSKPSHLV-DAHTAEVNCLSFNPYSE----FILATGSADKTVALWD 304 >2AQ5-A nrPDB Length = 402 Score = 45.1 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 16/82 (19%), Positives = 35/82 (42%), Gaps = 1/82 (1%) Query: 61 FDKHTDSVFAIGHHPNL-PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS 119 + HT V + HP ++ + G DN+ +W + + +++ S ++ Sbjct: 127 LEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSR 186 Query: 120 EGGFLVTADMSGKVLVHMGQKG 141 +G + T+ +V V +KG Sbjct: 187 DGALICTSCRDKRVRVIEPRKG 208 Score = 35.5 bits (80), Expect = 0.043, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 32/90 (35%), Gaps = 13/90 (14%) Query: 64 HTDSVFAIGHHPNL-PLVCTGGGDNLAHLWTSHSQPPKFAG--------TLTGYGESVIS 114 HT V I P+ ++ +G D +W P TL G+ + V Sbjct: 80 HTAPVLDIAWCPHNDNVIASGSEDCTVMVW---EIPDGGLVLPLREPVITLEGHTKRVGI 136 Query: 115 CSF-TSEGGFLVTADMSGKVLVHMGQKGGA 143 ++ + L++A +LV G A Sbjct: 137 VAWHPTAQNVLLSAGCDNVILVWDVGTGAA 166 >5OQL-L nrPDB Length = 557 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 40/193 (20%), Positives = 76/193 (39%), Gaps = 31/193 (16%) Query: 155 EEIVWL-KTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTD 213 ++ VW+ K PT T + D +V + + D + +L +G H G F+ Sbjct: 144 KQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPT--RLFTG--HTDYVRCGAFMPGS 199 Query: 214 KGENTLELVTCSLDSTIVAWNCFT-GQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSG 272 N LV+ S D T+ W+ G + A+ + P L G + Sbjct: 200 ANSNL--LVSGSYDETVRVWDARAPGGAVMTFKHADPIED--------VLP--LPSGTTL 247 Query: 273 VVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVC 332 + A G+ +L ++ L L T ++ S+S +S+ + G + Sbjct: 248 LAASGNAISVLDLV----AAKPLRLIT---------NHQKTVTSLSLASQGRRVVSGSLD 294 Query: 333 GEILLYDTSAWRV 345 G + +++T++W V Sbjct: 295 GHVKVFETTSWNV 307 >5Y1U-A nrPDB Length = 456 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 26/168 (15%), Positives = 56/168 (33%), Gaps = 17/168 (10%) Query: 33 GENDDDDEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLP-LVCTGGGDNLAHL 91 G DD ++M D + ++S+ D HT V + +P ++ TG D L Sbjct: 275 GSVADDQKLMIWDTRSNNTSKPSHSV---DAHTAEVNCLSFNPYSEFILATGSADKTVAL 331 Query: 92 WTSHSQPPKFAGTLTGYGESVISCSFT-SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQ 150 W + K + + + ++ L ++ ++ V K G + Sbjct: 332 WDLRNLKLKLHS-FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 390 Query: 151 MQEVEEIVWL-----------KTHPTIARTFAFGATDGSVWCYQINEQ 187 E++++ +P + D + +Q+ E Sbjct: 391 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 438 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 33/188 (17%), Positives = 60/188 (31%), Gaps = 25/188 (13%) Query: 64 HTDSVFAIGHHPNLPLVCTG---GGDNLAHLWTSHSQPPKFAGT------LTGYGESVIS 114 H V + P P + D L +T H P +G L G+ + Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 115 CSFT-SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQ-------MQEVEEIVWLKTHPTI 166 S+ + G L++A + + + K+ VE++ W H + Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES- 272 Query: 167 ARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSL 226 F A D + + + + + S H + + F + L T S Sbjct: 273 --LFGSVADDQKLMIW-DTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE----FILATGSA 325 Query: 227 DSTIVAWN 234 D T+ W+ Sbjct: 326 DKTVALWD 333 >3JZG-A nrPDB Length = 402 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 44/234 (18%), Positives = 89/234 (38%), Gaps = 38/234 (16%) Query: 56 NSLTYFDKHTDSVFAIGHHPNL----PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGY--- 108 NSL + H +F + + + PLV G N L+ HSQ L Y Sbjct: 47 NSLK--EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGE--IRLLQSYVDA 102 Query: 109 --GESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVW------- 159 E+ +C++T + ++ S +L G +G + MQ ++ V Sbjct: 103 DADENFYTCAWTYD------SNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINE 156 Query: 160 LKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFV-HQQDCSMGEFINTDKGENT 218 LK HP + D ++ + I +L + G H+ + ++ + Sbjct: 157 LKFHPRDPNLLLSVSKDHALRLWNIQTD--TLVAIFGGVEGHRDEVLSADYDLLGE---- 210 Query: 219 LELVTCSLDSTIVAWNCFTGQQLFKITQA---EIKGLEAPWISLSL-APETLTK 268 ++++C +D ++ W + + + I ++ P+IS + P+ T+ Sbjct: 211 -KIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 263 >6J6H-n nrPDB Length = 455 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 31/202 (15%), Positives = 71/202 (35%), Gaps = 16/202 (7%) Query: 36 DDDDEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLP-LVCTGGGDNLAHLWTS 94 +D D + ++ + + + + H + A+ P L+ +GG D+ +W Sbjct: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 Query: 95 HSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWK--LASQMQ 152 + G+ + + + FT + +++ V + + G + + L S Sbjct: 193 YHDYE-CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 Query: 153 EVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINT 212 +VE + PT F G ++ + Y + G V D + + Sbjct: 252 DVE------SRPTNPHEFIVGLSNSKILHYDDRVSENQ------GLVQTYDHHLSSILAL 299 Query: 213 DKGENTLELVTCSLDSTIVAWN 234 + + ++ S D T+ W Sbjct: 300 KYFPDGSKFISSSEDKTVRIWE 321 Score = 34.7 bits (78), Expect = 0.090, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 60/171 (35%), Gaps = 13/171 (7%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 F H + A+ + + D +W + + K L V S T+ Sbjct: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP-TNP 260 Query: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQM-QEVEEIVWLKTHPTIARTFAFGATDGSV 179 F+V S ++H + L + I+ LK P ++ F + D +V Sbjct: 261 HEFIVGLSNSK--ILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSK-FISSSEDKTV 317 Query: 180 WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTI 230 ++ N+ + ++Q+ H F+N +N S+D+ I Sbjct: 318 RIWE-NQINVPIKQISDTAQH-----SMPFLNVHPSQNYF--CAQSMDNRI 360 Score = 31.2 bits (69), Expect = 0.97, Method: Composition-based stats. Identities = 19/118 (16%), Positives = 39/118 (33%), Gaps = 19/118 (16%) Query: 74 HPNLPLVCTGGGDNLA---HLWTSHSQPPKFAGTLTGYGESV--ISCSFTSEGGFLVTAD 128 HP+ C DN L + + PK G+ + IS +F+ +G ++ + D Sbjct: 345 HPSQNYFCAQSMDNRIYSFSLKPKYKRHPK--KIFKGHSSAGYGISLAFSGDGRYICSGD 402 Query: 129 MSGKVLVHMGQKGGAQWKLASQMQEV-----EEIVWLKTHPTIARTFAFGATDGSVWC 181 ++ W + + + + I + HP G ++ Sbjct: 403 SKSRLFTW-------DWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYV 453 >5UZ7-B nrPDB Length = 351 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 61/173 (35%), Gaps = 17/173 (9%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 HT V ++ P+ L +G D A LW + T TG+ + + F G Sbjct: 194 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR--QTFTGHESDINAICFFPNGNA 251 Query: 124 LVTADMSGKVLVHM--GQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWC 181 T + + + + + + + + K+ R G D + Sbjct: 252 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS----GRLLLAGYDDFNCNV 307 Query: 182 YQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWN 234 + + D + +++G ++ C TD G + + T S DS + WN Sbjct: 308 WDALKADRA--GVLAGHDNRVSC----LGVTDDG---MAVATGSWDSFLKIWN 351 Score = 37.4 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 60/162 (37%), Gaps = 15/162 (9%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 TL G+ + + + ++ LV+A GK+++ K+ + ++ Sbjct: 61 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN---KVHAIPLRSSWVMTCAYA 117 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 P+ A G D Y + ++G++ H S F++ + ++VT Sbjct: 118 PS-GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN------QIVT 170 Query: 224 CSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPET 265 S D+T W G +SLSLAP+T Sbjct: 171 SSGDTTCALW-----DIETGQQTTTFTGHTGDVMSLSLAPDT 207 >5WLC-SG nrPDB Length = 573 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 41/215 (19%), Positives = 80/215 (37%), Gaps = 18/215 (8%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H D + + P+ V TGG D +W++ S P V+S +F Sbjct: 235 HYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQ 294 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 L + K+ + Q+ + +IV + + R GA D + ++ Sbjct: 295 LYASCADFKIRTYSIN----QFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 350 Query: 184 INEQD-------GSLEQLMSGFVHQ--QDCSMGEFINTDKGENTLELVTCSLD--STIVA 232 I ++ ++L+ ++ + ++ GE D+ E L S+D S + Sbjct: 351 IPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDD 410 Query: 233 WNCFTGQQLFKI---TQAEIKGLEAPWISLSLAPE 264 ++ TG I + A+ K + I+ + PE Sbjct: 411 FHFITGSDNGNICLWSLAKKKPIFTERIAHGILPE 445 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 59/158 (37%), Gaps = 15/158 (9%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 T G+ + +++ + + +G ++VT K++V + + K+ E++ L Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWST-ESLSPVKVIPTKDRRGEVLSLAFR 289 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELV- 222 + +A A D + Y IN+ S +++ G H I D +E Sbjct: 290 KNSDQLYASCA-DFKIRTYSINQ--FSQLEILYGH-HD--------IVEDISALAMERCV 337 Query: 223 -TCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISL 259 + D T + W +L E + L W+ Sbjct: 338 TVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKE 375 >4J0X-A nrPDB Length = 451 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 41/215 (19%), Positives = 80/215 (37%), Gaps = 18/215 (8%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 H D + + P+ V TGG D +W++ S P V+S +F Sbjct: 113 HYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQ 172 Query: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 L + K+ + Q+ + +IV + + R GA D + ++ Sbjct: 173 LYASCADFKIRTYSIN----QFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 228 Query: 184 INEQD-------GSLEQLMSGFVHQ--QDCSMGEFINTDKGENTLELVTCSLD--STIVA 232 I ++ ++L+ ++ + ++ GE D+ E L S+D S + Sbjct: 229 IPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDD 288 Query: 233 WNCFTGQQLFKI---TQAEIKGLEAPWISLSLAPE 264 ++ TG I + A+ K + I+ + PE Sbjct: 289 FHFITGSDNGNICLWSLAKKKPIFTERIAHGILPE 323 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 59/158 (37%), Gaps = 15/158 (9%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 T G+ + +++ + + +G ++VT K++V + + K+ E++ L Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWST-ESLSPVKVIPTKDRRGEVLSLAFR 167 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELV- 222 + +A A D + Y IN+ S +++ G H I D +E Sbjct: 168 KNSDQLYASCA-DFKIRTYSINQ--FSQLEILYGH-HD--------IVEDISALAMERCV 215 Query: 223 -TCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISL 259 + D T + W +L E + L W+ Sbjct: 216 TVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKE 253 >5N4A-A nrPDB Length = 771 Score = 41.6 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 46/236 (19%), Positives = 80/236 (33%), Gaps = 32/236 (13%) Query: 73 HHPNLPLVCTGGGDNLAHLWTSH------SQPPKFAGTLTGYGESVISCSFTSEGGFLVT 126 +P GG ++ + + S+ + ++ G+ + IS ++ +G L T Sbjct: 62 WYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALAT 121 Query: 127 ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINE 186 A G V + + G + LA V IVW A D CY Sbjct: 122 AGEDGSVKIW-SRNGMLRSTLAQADSPVYSIVW--------------AYDCDQLCYCT-- 164 Query: 187 QDGSLEQLMS-GFVHQQDCSM---GEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLF 242 GS + S +Q+ G + D ++T D W+ F G+ LF Sbjct: 165 --GSNVVIKSLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSF-GRLLF 221 Query: 243 KITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLS 298 + + W G + + C + I+ N+ G+I+ LS Sbjct: 222 QSGLFDYPVTSVAWAPSGELFAV--GGFNTLQLCDRMGWAYSKIHLNDTGSIMTLS 275 >3ACP-A nrPDB Length = 417 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 28/111 (25%), Positives = 45/111 (40%), Gaps = 10/111 (9%) Query: 154 VEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTD 213 V EI LK P+ + D + + + +DGS + + G H+ + D Sbjct: 136 VSEITKLKFFPS-GEALISSSQDMQLKIWSV--KDGSNPRTLIG--HRATV--TDIAIID 188 Query: 214 KGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPE 264 +G N L + SLD TI W C TG + + E I+L + + Sbjct: 189 RGRNVL---SASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTD 236 Score = 32.4 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 30/79 (37%), Gaps = 4/79 (5%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWT-SHSQPPKFAGTLTGYGESVISCSFTSEGG 122 H + + P+ + + D +W+ P+ TL G+ +V + G Sbjct: 135 HVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPR---TLIGHRATVTDIAIIDRGR 191 Query: 123 FLVTADMSGKVLVHMGQKG 141 +++A + G + + G Sbjct: 192 NVLSASLDGTIRLWECGTG 210 >1PI6-A nrPDB Length = 615 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 78/390 (20%), Positives = 129/390 (33%), Gaps = 105/390 (26%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPP-KFAGTLTGY---G 109 S NSL H+ + A + P+ GD+ + ++ + PP KF+ + + G Sbjct: 149 SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVF--YQGPPFKFSASDRTHHKQG 206 Query: 110 ESVISCSFTSE-GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQE-----VEEIVWLKTH 163 V F+ + G F++T K+ G K G K QE + + WL Sbjct: 207 SFVRDVEFSPDSGEFVITVGSDRKISCFDG-KSGEFLKYIEDDQEPVQGGIFALSWL--- 262 Query: 164 PTIARTFAFGATDGSVWCYQINE----QDGSLEQLMSGFVHQQDCSMGE----FINTDKG 215 ++ FA D ++ + + Q +L++ G + G ++ D Sbjct: 263 --DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGT 320 Query: 216 ENTLEL------------------------VTCSLDSTIVAWNCFTGQQLFKITQAEIKG 251 N EL ++ S D I+ W+ + Q + Sbjct: 321 LNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDN 380 Query: 252 LEAPWISLSLAPET--------LTKGNSGVVACGSNNGLLAV------------------ 285 +A S +T G+ VA +N+G AV Sbjct: 381 SKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDII 440 Query: 286 --INCNNGGAILHLST--------------VIELKPEQDELD------ASIESISWSSKF 323 + N+ G+ + LS V +L + D A IS S Sbjct: 441 KSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSE 500 Query: 324 SLMAIGLVCGEILLYD-------TSAWRVR 346 + +A G V G+ILLYD TS W R Sbjct: 501 TYIAAGDVMGKILLYDLQSREVKTSRWAFR 530 >4OWR-A nrPDB Length = 339 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 18/120 (15%), Positives = 37/120 (30%), Gaps = 6/120 (5%) Query: 66 DSVFAIGHHPNL---PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGG 122 DS+ + P + G N W + V+ ++ +G Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 70 Query: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 + TA + ++A V+ I W+K P + G+ D ++ + Sbjct: 71 KVFTASCDKTAKMWDL-SSNQAIQIAQHDAPVKTIHWIKA-PNYSCVM-TGSWDKTLKFW 127 Score = 35.5 bits (80), Expect = 0.048, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 22/60 (36%), Gaps = 2/60 (3%) Query: 45 DEEALEVDMSNNSLTYFDKHTDSVFAIGH--HPNLPLVCTGGGDNLAHLWTSHSQPPKFA 102 D+ A D+S+N +H V I PN V TG D W + S P Sbjct: 78 DKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMV 137 Score = 29.3 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 27/84 (32%), Gaps = 2/84 (2%) Query: 45 DEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGT 104 D + SN + T + +V I HP + T G D W ++ T Sbjct: 224 DNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTK--LKT 281 Query: 105 LTGYGESVISCSFTSEGGFLVTAD 128 + + +C F G A Sbjct: 282 SEQLDQPISACCFNHNGNIFAYAS 305 >3ODT-A nrPDB Length = 313 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 37/214 (17%), Positives = 74/214 (34%), Gaps = 44/214 (20%) Query: 70 AIGHHPNLPLVCTGGGDNLAH---LWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVT 126 ++ + L+ GG D + + L+ + + P TL G+ +V CS + + G +++ Sbjct: 64 SVCYDSEKELLLFGGKDTMINGVPLFATSGEDP--LYTLIGHQGNV--CSLSFQDGVVIS 119 Query: 127 ADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIART-FAFGATDGSVWCYQIN 185 V + L +Q VW + + F + D ++ +Q + Sbjct: 120 GSWDKTAKVW------KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQND 173 Query: 186 E-------------------QDGSLEQLMS-GFVHQQDCSMGEFINTDKGENTL------ 219 + DG + G + D G+ + T +G + Sbjct: 174 KVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKL 233 Query: 220 ----ELVTCSLDSTIVAWNCFTGQQLFKITQAEI 249 ++V+C D T+ W+ G IT I Sbjct: 234 LPNGDIVSCGEDRTVRIWSKENGSLKQVITLPAI 267 >3W15-A nrPDB Length = 368 Score = 38.9 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 27/154 (17%), Positives = 53/154 (34%), Gaps = 17/154 (11%) Query: 53 MSNNSLTYFDKHTDSVFAIGHHPN-LPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGY-GE 110 + S T K+ + V+ P+ LV + G++ A L+ K + G Sbjct: 164 LKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGL 223 Query: 111 SVISCSFTS-EGGFLVTADMSGKVLVH---MGQKGGAQWKLASQMQEV--------EEIV 158 ++C F + T + + + M K Q +S + E+ ++ Sbjct: 224 EALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVT 283 Query: 159 WLKTHPTIARTFAFGATDGSVWCYQINEQDGSLE 192 W H I + D + ++ DG+ E Sbjct: 284 WSPHHSNI---LMSASYDMTCRIWRDLSNDGAKE 314 >6E29-D nrPDB Length = 345 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Query: 79 LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMG 138 + +G D +W + A L G+ +++ S S++ G +L++A KV++ Sbjct: 39 FLASGRVDGTVVIWDLETMG--VARKLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDL 96 Query: 139 QKG 141 Q G Sbjct: 97 QDG 99 >5TF2-A nrPDB Length = 407 Score = 37.8 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 28/127 (22%), Positives = 45/127 (35%), Gaps = 22/127 (17%) Query: 47 EALEVDMSNNSLTYFDKHTDSVFAIG--HHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGT 104 E LE+ + N D +D + + +H N L+ TGG D +W + P Sbjct: 153 EGLELRVENLQAVQTDFSSDPLQKVVCFNHDNT-LLATGGTDGYVRVW----KVPSLEKV 207 Query: 105 LT--GYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKT 162 L + + + +G LVT K V Q V ++ W + Sbjct: 208 LEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVWQKD------------QLVTQLHWQEN 254 Query: 163 HPTIART 169 PT + T Sbjct: 255 GPTFSST 261 Score = 28.5 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 18/36 (50%), Gaps = 4/36 (11%) Query: 169 TFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDC 204 A G TDG V +++ SLE+++ H+ + Sbjct: 186 LLATGGTDGYVRVWKVP----SLEKVLEFKAHEGEI 217 >6ELZ-p nrPDB Length = 460 Score = 37.4 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 36/208 (17%), Positives = 72/208 (34%), Gaps = 39/208 (18%) Query: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF---------- 101 D+S N + H+ + A+ + N LV G D LW + + K Sbjct: 131 DLSGNVQKQYSGHSGPIRAVKYISNTRLVSAGN-DRTLRLWKTKNDDLKLTSQQQAQEDD 189 Query: 102 -----------AGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQ 150 L G+ V+S S+ +++A + +K + Sbjct: 190 DDEVNIEDGKTLAILEGHKAPVVSID-VSDNSRILSASYDNSIGFWSTI-----YKEMTV 243 Query: 151 MQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFI 210 + +E+I +P + A ++ +DG++ + + + + E + Sbjct: 244 VDPLEDI----NNPNNKISTAARKRR------KLTMKDGTIRRRAPLSLLESHTAPVEQV 293 Query: 211 NTDKGENTLELVTCSLDSTIVAWNCFTG 238 D +NT+ + S D TI W+ T Sbjct: 294 IFDSTDNTVGY-SVSQDHTIKTWDLVTA 320 Score = 35.9 bits (81), Expect = 0.038, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 35/83 (42%), Gaps = 8/83 (9%) Query: 64 HTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTSHSQPPKFAGTLT------GYGESVISCS 116 H + V ++ P N ++C+G D +W S P + T G + V + Sbjct: 374 HKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVK 433 Query: 117 FTSEGGFLVTADMSGKVLVHMGQ 139 + + G +++A K+ ++ G Sbjct: 434 WAEKVG-IISAGQDKKIQINKGD 455 Score = 31.2 bits (69), Expect = 0.83, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 26/75 (34%), Gaps = 13/75 (17%) Query: 172 FGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIV 231 G+ DG V + +SG V +Q I K + LV+ D T+ Sbjct: 120 SGSYDGIVRTWD-----------LSGNVQKQYSGHSGPIRAVKYISNTRLVSAGNDRTLR 168 Query: 232 AWNCFTGQQLFKITQ 246 W T K+T Sbjct: 169 LWK--TKNDDLKLTS 181 >5BJS-A nrPDB Length = 605 Score = 37.4 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 16/134 (11%), Positives = 43/134 (32%), Gaps = 13/134 (9%) Query: 64 HTDSVFAIGHHPNLP-LVCTGGGDNLAHLWT----SHSQPPKFAGTLTGYGESVISCSFT 118 H + + P P ++ + D +W+ QP G+ ++S +F Sbjct: 177 HGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFH 236 Query: 119 SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAF------ 172 G ++++A + + + + + + H + AF Sbjct: 237 DNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLIL 296 Query: 173 --GATDGSVWCYQI 184 + ++ ++I Sbjct: 297 SRACHEDTIVLWRI 310 Score = 29.7 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 50/154 (32%), Gaps = 31/154 (20%) Query: 85 GDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKV--LVHMGQKGG 142 D + ++ PP FA T + + C T T D ++ + + G Sbjct: 81 FDVKFYPYSPPGAPPVFAATSKKH---AVICRLTQ------TTDKDANPCEIIQLIRDDG 131 Query: 143 AQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQ 202 + AS W K T +G+V Y + E G +++ Sbjct: 132 NEANCAS--------CWSKDPITDQPLLCIAGNEGNVKVYNVTE----------GKLYRT 173 Query: 203 DCSMGEFINTDKGE--NTLELVTCSLDSTIVAWN 234 G IN N + + S D+TI W+ Sbjct: 174 LVGHGGGINDLATSPANPYIIASASDDTTIRIWS 207 >5WBU-D nrPDB Length = 328 Score = 36.6 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 19/95 (20%), Positives = 34/95 (35%), Gaps = 8/95 (8%) Query: 59 TYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLW-TSHSQPPKFAGTLTGY-GESVIS-- 114 T HT P+ L+ T D +W TS+ +G GES Sbjct: 216 TKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWM 275 Query: 115 --CSFTSEGGFLVTADMS--GKVLVHMGQKGGAQW 145 C+F+ + ++VTA ++ + ++ Sbjct: 276 WGCAFSGDSQYIVTASSDNLARLWCVETGEIKREY 310 Score = 36.2 bits (82), Expect = 0.026, Method: Composition-based stats. Identities = 21/129 (16%), Positives = 44/129 (34%), Gaps = 5/129 (3%) Query: 63 KHTDS-VFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEG 121 +H DS V A+ P+ ++ G + ++ +S P + G +++ S F +G Sbjct: 41 QHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDG 99 Query: 122 GFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWC 181 ++ T + + Q I + HP A G G++ Sbjct: 100 RWMYTGGEDCTARIW--DLRSRNLQCQRIFQVNAPINCVCLHPNQAELIV-GDQSGAIHI 156 Query: 182 YQINEQDGS 190 + + Sbjct: 157 WDLKTDHNE 165 Score = 28.5 bits (62), Expect = 6.4, Method: Composition-based stats. Identities = 7/82 (8%), Positives = 23/82 (28%), Gaps = 4/82 (4%) Query: 105 LTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLA----SQMQEVEEIVWL 160 + + + C F+ + L T + +L+ + + +W Sbjct: 218 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWG 277 Query: 161 KTHPTIARTFAFGATDGSVWCY 182 ++ ++D + Sbjct: 278 CAFSGDSQYIVTASSDNLARLW 299 >5FA5-B nrPDB Length = 367 Score = 36.6 bits (83), Expect = 0.021, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 51/147 (34%), Gaps = 14/147 (9%) Query: 63 KHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFT--SE 120 +H D V + + +G D +W Q + + V + + + Sbjct: 148 EHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV--VLSSYRAHAAQVTCVAASPHKD 205 Query: 121 GGFLVTADMSGKVLVHMGQ--KGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGS 178 FL + ++L+ + K +Q ++ + W HP + F FG +G+ Sbjct: 206 SVFL-SCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAW---HPQQSEVFVFGDENGT 261 Query: 179 VWCYQINEQDGSLEQLMSGFVHQQDCS 205 V S ++S VH Q + Sbjct: 262 VSLV----DTKSTSCVLSSAVHSQCVT 284 >4BTS-AR nrPDB Length = 343 Score = 36.2 bits (82), Expect = 0.024, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 24/64 (37%), Gaps = 3/64 (4%) Query: 74 HPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKV 133 P P + G D +W ++ Q T + +V S + G ++ T K+ Sbjct: 181 QPFAPYFASVGWDGRLKVWNTNFQ---IRYTFKAHESNVNHLSISPNGKYIATGGKDKKL 237 Query: 134 LVHM 137 L+ Sbjct: 238 LIWD 241 Score = 34.3 bits (77), Expect = 0.096, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 41/101 (40%), Gaps = 11/101 (10%) Query: 166 IARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFIN--TDKGENTLELVT 223 + G+ D +V +++ E++ + G H+ F++ EN + + Sbjct: 38 DSPVLISGSRDKTVMIWKLYEEE---QNGYFGIPHKALTGHNHFVSDLALSQENCFAI-S 93 Query: 224 CSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPE 264 S D T+ W+ TG T G ++ S++ +P+ Sbjct: 94 SSWDKTLRLWDLRTG-----TTYKRFVGHQSEVYSVAFSPD 129 Score = 30.1 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 33/180 (18%), Positives = 63/180 (35%), Gaps = 29/180 (16%) Query: 25 QDVPVDIEGENDDDDEM--MNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCT 82 +D PV I G D + + ++E+ + + +LT H V + + Sbjct: 37 EDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALT---GHNHFVSDLALSQENCFAIS 93 Query: 83 GGGDNLAHLW--TSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQK 140 D LW + + +F G+ V S +F+ + +++A ++ + Sbjct: 94 SSWDKTLRLWDLRTGTTYKRFV----GHQSEVYSVAFSPDNRQILSAGAEREIKLWNIL- 148 Query: 141 GGAQWKLASQMQEVEEIVWL-------------KTHPTIARTFAFGATDGSVWCYQINEQ 187 + K +S +E W+ K P A FA DG + + N Q Sbjct: 149 --GECKFSSAEKE-NHSDWVSCVRYSPIMKSANKVQP-FAPYFASVGWDGRLKVWNTNFQ 204 >5A9Q-0 nrPDB Length = 380 Score = 35.9 bits (81), Expect = 0.037, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 23/70 (32%), Gaps = 3/70 (4%) Query: 71 IGHHPNLP-LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF-TSEGGFLVTAD 128 + HPN +V TGG D + +W Q L + + F S L T Sbjct: 223 VDRHPNQQHVVATGGQDGMLSIWDVR-QGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCS 281 Query: 129 MSGKVLVHMG 138 G + Sbjct: 282 EDGSLWHWDA 291 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 44/115 (38%), Gaps = 8/115 (6%) Query: 124 LVTADMSGKVLVHM-GQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 ++T + G++ + Q+G ++ S + + + HP A G DG + + Sbjct: 186 ILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIW 245 Query: 183 QINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFT 237 Q L+ H+ + F + N L TCS D ++ W+ T Sbjct: 246 -DVRQGTMPVSLLKA--HEAEMWEVHFHPS----NPEHLFTCSEDGSLWHWDAST 293 >4U1E-I nrPDB Length = 347 Score = 35.9 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 26/89 (29%), Gaps = 6/89 (6%) Query: 105 LTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHP 164 LTG+ + + EG L + V G + + +W Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNG----ERLGTLDGHTGTIWSIDVD 61 Query: 165 TIARTFAFGATDGSVWCYQINEQDGSLEQ 193 + G+ D S+ + + +G Sbjct: 62 CFTKYCVTGSADYSIKLWDV--SNGQCVA 88 >6CHG-D nrPDB Length = 439 Score = 35.9 bits (81), Expect = 0.041, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 48/129 (37%), Gaps = 12/129 (9%) Query: 71 IGHHPNLPLVCTGGGDNLAHLWTSHS-QPPKFAGTLTG-YGESVISCSFTSEGGFLVTAD 128 + P + G + ++ S +P GT +G + SV S ++++G +L ++ Sbjct: 33 VKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWSSG 92 Query: 129 MSGKVLVH-MGQ--KGGAQWKLASQMQEVEEIVW------LKTHPTIARTFAFGATDGSV 179 + M Q K Q+K + + W + PT A + Sbjct: 93 RDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEPT-AYVLTLTDRQNAF 151 Query: 180 WCYQINEQD 188 C+ + EQD Sbjct: 152 HCFPLLEQD 160 >6EM1-m nrPDB Length = 807 Score = 35.5 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 27/56 (48%), Gaps = 5/56 (8%) Query: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWI-SLSLAPETLTKGNSGVVA 275 L T S D T+ W TG+++++ T + + I + P+ N+G++A Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPD----ANNGILA 503 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 16/100 (16%), Positives = 34/100 (34%), Gaps = 11/100 (11%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF-------A 102 ++D+++ H +V ++ H LPL + D H++ + Sbjct: 708 DLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPL 767 Query: 103 GTLTGYG--ES--VISCSFTSEGGFLVTADMSGKVLVHMG 138 LTG+ S V+ + +L +A + Sbjct: 768 KKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWTT 807 Score = 31.6 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 18/49 (36%) Query: 98 PPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWK 146 P + + G+ V + S G +L T G V V G ++ Sbjct: 426 PIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYR 474 >6CB1-s nrPDB Length = 569 Score = 35.5 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 27/56 (48%), Gaps = 5/56 (8%) Query: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWI-SLSLAPETLTKGNSGVVA 275 L T S D T+ W TG+++++ T + + I + P+ N+G++A Sbjct: 214 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPD----ANNGILA 265 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 16/100 (16%), Positives = 34/100 (34%), Gaps = 11/100 (11%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF-------A 102 ++D+++ H +V ++ H LPL + D H++ + Sbjct: 470 DLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPL 529 Query: 103 GTLTGYG--ES--VISCSFTSEGGFLVTADMSGKVLVHMG 138 LTG+ S V+ + +L +A + Sbjct: 530 KKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWTT 569 Score = 31.6 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 18/49 (36%) Query: 98 PPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWK 146 P + + G+ V + S G +L T G V V G ++ Sbjct: 188 PIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYR 236 >6C0F-s nrPDB Length = 807 Score = 35.5 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 27/56 (48%), Gaps = 5/56 (8%) Query: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWI-SLSLAPETLTKGNSGVVA 275 L T S D T+ W TG+++++ T + + I + P+ N+G++A Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPD----ANNGILA 503 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 16/100 (16%), Positives = 34/100 (34%), Gaps = 11/100 (11%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKF-------A 102 ++D+++ H +V ++ H LPL + D H++ + Sbjct: 708 DLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPL 767 Query: 103 GTLTGYG--ES--VISCSFTSEGGFLVTADMSGKVLVHMG 138 LTG+ S V+ + +L +A + Sbjct: 768 KKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWTT 807 Score = 31.6 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 18/49 (36%) Query: 98 PPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWK 146 P + + G+ V + S G +L T G V V G ++ Sbjct: 426 PIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYR 474 >3DWL-C nrPDB Length = 377 Score = 35.1 bits (79), Expect = 0.060, Method: Composition-based stats. Identities = 15/103 (14%), Positives = 31/103 (30%) Query: 87 NLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWK 146 N L+ K A T + + + V + + +VT V+ + G + Sbjct: 33 NQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQ 92 Query: 147 LASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDG 189 ++ +++ P + CY E D Sbjct: 93 TLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDW 135 Score = 32.0 bits (71), Expect = 0.50, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 33/77 (42%), Gaps = 3/77 (3%) Query: 68 VFAIGHHPNLPLVCTGGGDNLAHLW--TSHSQPPKFAGTLTGYGESVISCSFTSEGGFLV 125 V A+G P+ + G D+ + ++ QPP+ T+ + S + +E +V Sbjct: 208 VHAVGFSPSGNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLWANESA-IV 266 Query: 126 TADMSGKVLVHMGQKGG 142 A + ++ G + G Sbjct: 267 AAGYNYSPILLQGNESG 283 Score = 28.5 bits (62), Expect = 5.4, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 30/66 (45%), Gaps = 13/66 (19%) Query: 43 NDDEEALEVDMSNNSLTYFDKHTD-------------SVFAIGHHPNLPLVCTGGGDNLA 89 N+D+ A+ S+ YF++ D ++ ++ HPN L+ G D A Sbjct: 111 NEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKA 170 Query: 90 HLWTSH 95 ++ +++ Sbjct: 171 YVLSAY 176 >5WLC-LS nrPDB Length = 594 Score = 35.1 bits (79), Expect = 0.068, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 25/51 (49%) Query: 67 SVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 ++ ++ HP+ PL+ TGG D ++ + +L G + +C+F Sbjct: 250 AIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTF 300 >5CXC-A nrPDB Length = 510 Score = 33.9 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 26/83 (31%), Gaps = 14/83 (16%) Query: 163 HPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQ---DCSMGEFINTDKGENTL 219 P R + DG + + GS+ H +F+ +D Sbjct: 155 QPGQERVL-SASYDGLLRIW---NASGSVIATSPSGSHGGHTASIKAAKFLTSD------ 204 Query: 220 ELVTCSLDSTIVAWNCFTGQQLF 242 L + +D T+ W +T F Sbjct: 205 RLASAGMDRTVRVWK-YTESDHF 226 Score = 31.2 bits (69), Expect = 0.78, Method: Composition-based stats. Identities = 48/258 (18%), Positives = 84/258 (32%), Gaps = 47/258 (18%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLT------GYGESVISCSF 117 HT S+ A + + G D +W +++ F G L G+ SV Sbjct: 191 HTASIKA-AKFLTSDRLASAGMDRTVRVW-KYTESDHFTGELKPTLELYGHTGSVDWLDV 248 Query: 118 TSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDG 177 ++TA G + K A AS + + + A + A G Sbjct: 249 DGHSKHILTASADGAIGFWSASKASAPEPDASLLPGA-HV----SKRRKATSSVSTAQRG 303 Query: 178 SVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFT 237 + + I H + F D+ + S D T+ + T Sbjct: 304 PLGLWSI---------------HTAPATAAIFDPRDRTVAY----SASQDHTVRTLDLTT 344 Query: 238 GQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAIL-- 295 GQ + +T L P +SLS T S ++A G++ + +++ A Sbjct: 345 GQVVSTLT------LTHPLLSLSALTRAGT--TSPLLAAGTSARHITMVDPRASSATTSV 396 Query: 296 -----HLSTVIELKPEQD 308 H + V+ L P + Sbjct: 397 MTLRGHANKVVSLSPSPE 414 >2XOT-A nrPDB Length = 361 Score = 33.9 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 27/117 (23%), Positives = 51/117 (43%), Gaps = 14/117 (11%) Query: 186 EQDGSLEQLMSGFVHQQDCSMGEF------INTDKGENTLEL----VTCSLDSTIVAWNC 235 E D L QL S + ++Q S+ +F +++ K N L + +S AW Sbjct: 202 ECDCKLYQLFSHWQYRQLSSVMDFQEDLYCMHSKKLHNIFSLDFFNCSEYKES---AWEA 258 Query: 236 FTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGG 292 G L + +G+ W+S S + L++G++G V+ + + + +GG Sbjct: 259 HLGDTLTIRCDTKQQGMTKVWVSPS-NEQVLSQGSNGSVSVRNGDLFFKKVQVEDGG 314 >5MWJ-A nrPDB Length = 337 Score = 33.9 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 16/119 (13%), Positives = 35/119 (29%), Gaps = 4/119 (3%) Query: 68 VFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTA 127 + + P+ + GG + +W + P+ LT + + + + + + Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 159 Query: 128 DMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINE 186 G + V L Q Q + G D +V + + E Sbjct: 160 CSDGNIAVWDLHNQ----TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE 214 Score = 33.9 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 64/185 (34%), Gaps = 23/185 (12%) Query: 67 SVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVT 126 + +A+ P+ + + D +W H+Q G+ + +++G L T Sbjct: 143 ACYALAISPDSKVCFSCCSDGNIAVWDLHNQT--LVRQFQGHTDGASCIDISNDGTKLWT 200 Query: 127 ADMSGKVLVHMGQKGGAQWKLASQMQE---VEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 + V ++G Q+Q+ +I L PT A G +V Sbjct: 201 GGLDNTVRSWDLREG-------RQLQQHDFTSQIFSLGYCPT-GEWLAVGMESSNVEVLH 252 Query: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFK 243 +N+ D L H+ +F K V+ D+ + AW G +F+ Sbjct: 253 VNKPDKYQLHL-----HESCVLSLKFAYCGKW-----FVSTGKDNLLNAWRTPYGASIFQ 302 Query: 244 ITQAE 248 ++ Sbjct: 303 SKESS 307 Score = 32.0 bits (71), Expect = 0.51, Method: Composition-based stats. Identities = 20/133 (15%), Positives = 49/133 (36%), Gaps = 11/133 (8%) Query: 109 GESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIAR 168 + SC +G L+ + + + ++ +++ + ++ Sbjct: 97 DNYIRSCKLLPDGCTLIVGGEASTLSIW--DLAAPTPRIKAELTSSAPACYALAISPDSK 154 Query: 169 TFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDS 228 +DG++ + ++ Q +L + G C D + +L T LD+ Sbjct: 155 VCFSCCSDGNIAVWDLHNQ--TLVRQFQGHTDGASC-------IDISNDGTKLWTGGLDN 205 Query: 229 TIVAWNCFTGQQL 241 T+ +W+ G+QL Sbjct: 206 TVRSWDLREGRQL 218 >3JB9-S nrPDB Length = 488 Score = 33.9 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 29/129 (22%), Positives = 48/129 (37%), Gaps = 11/129 (8%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPN-LPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESV 112 S N LT F H+ V + N LV T D+ +W + + V Sbjct: 364 SGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKS--ELVQKIP-LQTKV 420 Query: 113 ISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQ--MQEVEEIVWLKTHPTIARTF 170 + S LV++D + VH+ K W+ SQ + + +VWL Sbjct: 421 AAVSLDITSQLLVSSD-GETLYVHIYVKSSKSWRCMSQTHVSSISNLVWL----NELHQL 475 Query: 171 AFGATDGSV 179 F ++G++ Sbjct: 476 LFSTSNGAI 484 >5OQL-X nrPDB Length = 630 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 9/80 (11%), Positives = 24/80 (30%), Gaps = 2/80 (2%) Query: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 F +H D+V + + + D +W+ + TL G+ + ++ + Sbjct: 284 FTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELA--YVETLFGHQDEILDIDALGQ 341 Query: 121 GGFLVTADMSGKVLVHMGQK 140 + + Sbjct: 342 ERCVSVGARDRTARYWKVPE 361 Score = 33.5 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 28/163 (17%), Positives = 56/163 (34%), Gaps = 26/163 (15%) Query: 79 LVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMG 138 LV GGG+ + H PP + S+ + + F VT +G + + Sbjct: 365 LVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMF-VTGSDNGDLALWSI 423 Query: 139 QKGGAQWKLASQMQEVEEIVWLKTH-------PTI-----------------ARTFAFGA 174 Q+ + ++ +E + L+ + P+I + G+ Sbjct: 424 QRK-KPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGS 482 Query: 175 TDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGEN 217 DG + ++++E LE + V + C I+ N Sbjct: 483 WDGCIRVWRLSEDKRKLEAVGILGVGSETCENSTNISNGATSN 525 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 20/131 (15%), Positives = 47/131 (35%), Gaps = 13/131 (9%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 T G+ ++ + + +G F+VT +++V+ A K + + V Sbjct: 241 TYQGHLKAPLVVKASQDGKFVVTGGADKRLVVY----NAADLKPIKAFTQHRDAVTGLAF 296 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 + D +V + ++E L + + F HQ + + + ++ + Sbjct: 297 RRGTNQLYSCSKDRTVKVWSLDE----LAYVETLFGHQDEILDIDALGQERCVSV----- 347 Query: 224 CSLDSTIVAWN 234 + D T W Sbjct: 348 GARDRTARYWK 358 >5K0Y-T nrPDB Length = 329 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 25/138 (18%), Positives = 38/138 (27%), Gaps = 55/138 (39%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTH 163 L G+ S+ + EG L T V V G Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNG---------------------- 42 Query: 164 PTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVT 223 R + G+VWC + D + ++ T Sbjct: 43 ---ERLGTYMGHTGAVWCV---DADWDTKHVL---------------------------T 69 Query: 224 CSLDSTIVAWNCFTGQQL 241 S D++ W+C TG+QL Sbjct: 70 GSADNSCRLWDCETGKQL 87 >3EF1-A nrPDB Length = 442 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 5/60 (8%) Query: 3 PQEEFITTEEVEQEIV----PTVEVEQDVPVDI-EGENDDDDEMMNDDEEALEVDMSNNS 57 P E F+ ++ + P E EQ +P++I + E D DE+ ++EE E D SN+S Sbjct: 176 PYEFFVGIGDINSNFLAKSTPLPEQEQLIPLEIPKDEPDSVDEINEENEETPEYDSSNSS 235 >6F1U-h nrPDB Length = 612 Score = 32.8 bits (73), Expect = 0.32, Method: Composition-based stats. Identities = 15/111 (13%), Positives = 30/111 (27%), Gaps = 9/111 (8%) Query: 83 GGGDNLAHLWTSHSQPPKFAGTLTGYGESVIS------CSFTSEGGFLVTADMSGKVLVH 136 G + + H + G+ + VT+ V + Sbjct: 424 GSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLW 483 Query: 137 MGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 + + V +++W THP FA G + + +N Sbjct: 484 STKNNKPLYSFEDNAGYVYDVMWSPTHPA---LFACVDGMGRLDLWNLNND 531 >5WLC-LU nrPDB Length = 489 Score = 32.8 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 28/147 (19%), Positives = 50/147 (34%), Gaps = 23/147 (15%) Query: 170 FAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCS--------MGEFINTDKGENTLEL 221 A G+ DG + + ++ + E+ +S H + + K +N + Sbjct: 83 LATGSADGVIKYWNMSTR----EEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNF--M 136 Query: 222 VTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNG 281 ++CS D T+ W+ ++ + E L + G A + Sbjct: 137 LSCSDDKTVKLWSINV-DDYSNKNSSDNDSVTNE--------EGLIRTFDGESAFQGIDS 187 Query: 282 LLAVINCNNGGAILHLSTVIELKPEQD 308 GGA +HL V LKP D Sbjct: 188 HRENSTFATGGAKIHLWDVNRLKPVSD 214 >5CXB-B nrPDB Length = 369 Score = 32.4 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 17/72 (23%), Positives = 28/72 (38%), Gaps = 3/72 (4%) Query: 59 TYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF- 117 T F H V ++ P + TGG D +W + ++ L G E+V + + Sbjct: 15 TIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNTVRWR 73 Query: 118 -TSEGGFLVTAD 128 T + L A Sbjct: 74 PTKDTFILAAAA 85 Score = 31.6 bits (70), Expect = 0.64, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 22/71 (30%), Gaps = 1/71 (1%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQE-VEEIVWLKT 162 G+ V S + G L T G V V G W + E V + W T Sbjct: 16 IFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPT 75 Query: 163 HPTIARTFAFG 173 T A G Sbjct: 76 KDTFILAAAAG 86 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 34/100 (34%), Gaps = 12/100 (12%) Query: 50 EVDMSNNSLTYFDKHTDSVFAIGHHP-NLPLVCTGGGDNLAHLWTSHSQPPKF------- 101 ++D+SN HT+++ A+ H LPL D ++ + Sbjct: 270 DLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVP 329 Query: 102 AGTLTGYGE----SVISCSFTSEGGFLVTADMSGKVLVHM 137 L G+ V+ + + V+A G + M Sbjct: 330 VKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLWM 369 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 18/34 (52%), Gaps = 3/34 (8%) Query: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEA 254 L T D T+ W TG+Q++ + ++ G EA Sbjct: 36 LATGGDDGTVRVWELLTGRQVWSV---KLNGDEA 66 >5OV3-A nrPDB Length = 381 Score = 32.0 bits (71), Expect = 0.56, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 32/87 (36%), Gaps = 6/87 (6%) Query: 78 PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHM 137 L+ G D +W ++ A ++ + V S ++ +G LV+A V Sbjct: 38 TLLAVGCNDGRIVIWDFLTRG--IAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWD 95 Query: 138 GQKGGAQWKLASQMQEVEEIVWLKTHP 164 G + + I+ ++ HP Sbjct: 96 VLSG----DCDQRFRFPSPILKVQYHP 118 >1P49-A nrPDB Length = 562 Score = 31.6 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 1/58 (1%) Query: 75 PNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTG-YGESVISCSFTSEGGFLVTADMSG 131 PN+ + +GG HL S P A +TG Y S++ G FL TA G Sbjct: 32 PNIDRLASGGVKLTQHLAASPLATPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGG 89 >6BX3-B nrPDB Length = 412 Score = 31.6 bits (70), Expect = 0.73, Method: Composition-based stats. Identities = 27/130 (20%), Positives = 46/130 (35%), Gaps = 12/130 (9%) Query: 39 DEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHH-----PNLP--LVCTGGGDNLAHL 91 D + E +++ + S LT K+ D + + + N LV + G + L Sbjct: 234 DRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHEL 293 Query: 92 WTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTAD---MSGKVLVHMGQKGGAQWKLA 148 + + L G E +I ++ + + SG V V LA Sbjct: 294 YIWETTSGTLVRVLEGAEEELIDINW--DFYSMSIVSNGFESGNVYVWSVVIPPKWSALA 351 Query: 149 SQMQEVEEIV 158 +EVEE V Sbjct: 352 PDFEEVEENV 361 Score = 29.7 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 16/37 (43%) Query: 104 TLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQK 140 L + + S +++ +G L+T+ + + K Sbjct: 66 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSK 102 Score = 29.7 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 21/54 (38%), Gaps = 2/54 (3%) Query: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 H + +I P+ L+ T D LW S+P K + + + C + Sbjct: 70 HVRPITSIAWSPDGRLLLTSSRDWSIKLW-DLSKPSKPLKEIR-FDSPIWGCQW 121 >5A9Q-2 nrPDB Length = 326 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 25/109 (22%), Positives = 40/109 (36%), Gaps = 21/109 (19%) Query: 137 MGQKGGAQWKLASQMQE---VEEIVW-----LKTHPTIARTFAFGATDGSVWCYQINEQD 188 G Q+K V+ I W L + P + + F A D + + + QD Sbjct: 55 EADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIK-FCTSAADMKIRLFTSDLQD 113 Query: 189 GSLEQLMSGFVHQQDCSMGEFINT---DKGENTLELVTCSLDSTIVAWN 234 + +++ G +FIN D E E+ + S D T WN Sbjct: 114 KNEYKVLEGH--------TDFINGLVFDPKEGQ-EIASVSDDHTCRIWN 153 >3I2N-A nrPDB Length = 357 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 22/91 (24%), Positives = 44/91 (48%), Gaps = 9/91 (9%) Query: 300 VIELKPEQDELDASIESISWSSKFS----LMAIGLVCGEILLYDTSAWRVRHKFVLEDSV 355 V ++P Q E ++++ + ++ ++ G G+I L+D +R + +++ V Sbjct: 153 VANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNGV 212 Query: 356 TKLMFDNDD-----LFASCINGKVYQFNART 381 L FD D L A+ + GK + F+ RT Sbjct: 213 CSLEFDRKDISMNKLVATSLEGKFHVFDMRT 243 >5WLC-LH nrPDB Length = 896 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 12/57 (21%), Positives = 25/57 (43%) Query: 51 VDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTG 107 V +++ + H DSV ++ + + +GG + + LW + +F L G Sbjct: 283 VSLADLQIRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNG 339 Score = 28.5 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 35/89 (39%), Gaps = 6/89 (6%) Query: 57 SLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCS 116 SL+Y ++ S+ L + G ++ L L + +SV+S S Sbjct: 251 SLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSL------ADLQIRLLKWHIDSVLSLS 304 Query: 117 FTSEGGFLVTADMSGKVLVHMGQKGGAQW 145 F+ +G +L++ + + + Q+ Sbjct: 305 FSHDGSYLLSGGWEKVMSLWQLETNSQQF 333 >4PSX-B nrPDB Length = 401 Score = 30.1 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 41/116 (35%), Gaps = 20/116 (17%) Query: 139 QKGGAQWK-----------LASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQ 187 ++ G +++ + ++ + EEI + P A G+ + Y +E Sbjct: 92 EEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG 151 Query: 188 DGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFK 243 S + H+ + F KG L++ S D T+ W +G K Sbjct: 152 LQSTLKF-----HKDNGYALSFSTLVKG----RLLSGSDDHTVALWEVGSGGDPTK 198 >2HNK-A nrPDB Length = 239 Score = 29.3 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 30/136 (22%), Positives = 51/136 (37%), Gaps = 10/136 (7%) Query: 47 EALEVDMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFA--GT 104 E+LE + NS+ D G + + ++ T S + GT Sbjct: 10 ESLEEYIFRNSVREPDSFLKLRKETGTLAQANMQISPEEGQFLNILTKISGAKRIIEIGT 69 Query: 105 LTGYGESVISCSFTSEGGFLVTADMS-------GKVLVHMGQKGGAQWKLASQMQEVEEI 157 TGY + + +G L D+S K G + KL S ++ ++ + Sbjct: 70 FTGYSSLCFASALPEDGKILC-CDVSEEWTNVARKYWKENGLENKIFLKLGSALETLQVL 128 Query: 158 VWLKTHPTIARTFAFG 173 + K+ P+ A FAFG Sbjct: 129 IDSKSAPSWASDFAFG 144 >5K19-A nrPDB Length = 569 Score = 29.3 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 30/83 (36%), Gaps = 2/83 (2%) Query: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 + N L + ++ P+ + D ++ S + GT+ Y ++ Sbjct: 209 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSV--ELHGTMKSYFGGLL 266 Query: 114 SCSFTSEGGFLVTADMSGKVLVH 136 ++ +G ++VT V V Sbjct: 267 CVCWSPDGKYIVTGGEDDLVTVW 289 >3VX8-B nrPDB Length = 292 Score = 28.9 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 10/88 (11%) Query: 25 QDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTYFDKHTDSVFAIGHHP-NLPLVCTG 83 Q +P GE DDD M + +EA V + N+ T S + + H P + ++ T Sbjct: 119 QSIPTYFGGEEDDDIPDMEEFDEADNV-VENDPATL-----QSTYLVAHEPDDDNILRTR 172 Query: 84 GGDNLAHLWTSHSQPPKFAGTLTGYGES 111 D L+ + + Q P+ LTGY ES Sbjct: 173 TYD-LSITYDKYYQTPRVW--LTGYDES 197 >5WLC-LK nrPDB Length = 575 Score = 28.9 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 41/224 (18%), Positives = 86/224 (38%), Gaps = 27/224 (12%) Query: 3 PQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNS----- 57 P + ++IV ++ ++++ + + D+ D + D ++ ++ NNS Sbjct: 107 PDGRIVVYSSNGKDIVNIIKNKKEI---LGADTDESDIWILDSDKVVKKLQYNNSKPLKT 163 Query: 58 LTYFDKHTDSV--FAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISC 115 T D D + F I H LVC + ++ + P + ++C Sbjct: 164 FTLVDGKDDEIVHFQILHQNGTLLVCIIT-KQMVYIVDPSKRRPSTKYSFE--ISDAVAC 220 Query: 116 SFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGAT 175 F+S+G +L+ A+ + + + KL V +KT T+ T Sbjct: 221 EFSSDGKYLLIANNEELIAYDLKEDS----KLIQSWP-----VQVKTLKTLDDLIMALTT 271 Query: 176 DGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTL 219 DG + Y+I E D +++ +D + +F + + L Sbjct: 272 DGKINNYKIGEADKVCSIVVN-----EDLEIIDFTPINSKQQVL 310 >2JIS-A nrPDB Length = 515 Score = 28.9 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 24/79 (30%), Positives = 39/79 (49%), Gaps = 9/79 (11%) Query: 271 SGVVACGSNNGLLAVIN-CNNGGAILHLS-----TVIELKPEQDELDA--SIESISWSSK 322 SG G+ + L A+ + C G LH+ +V+ + + LD +S++W+ Sbjct: 267 SGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPH 326 Query: 323 FSLMAIGLVCGEILLYDTS 341 L+A GL C +LL DTS Sbjct: 327 -KLLAAGLQCSALLLQDTS 344 >5WLC-LN nrPDB Length = 776 Score = 28.5 bits (62), Expect = 5.4, Method: Composition-based stats. Identities = 25/102 (24%), Positives = 46/102 (45%), Gaps = 7/102 (6%) Query: 287 NCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVR 346 N N G +LH V + K E + S+ + + +A G G I +D + Sbjct: 218 NDENMGRLLHTMKVDKAKKES----TLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLN 273 Query: 347 HKFVLEDS-VTKLMFDNDD--LFASCINGKVYQFNARTGQEK 385 F D+ V L D D+ +F++ ++ K++QF+ T + + Sbjct: 274 QSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQ 315 >5LTD-A nrPDB Length = 525 Score = 27.8 bits (60), Expect = 8.7, Method: Composition-based stats. Identities = 15/86 (17%), Positives = 34/86 (39%), Gaps = 1/86 (1%) Query: 103 GTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKT 162 + + S+ + + + +G L TA G ++ G + + +I L Sbjct: 216 SVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAF 275 Query: 163 HPTIARTFAFGATDGSVWCYQINEQD 188 P A AT+ +V +++ E++ Sbjct: 276 SPDNRFVIASSATE-TVHIFRLGEEE 300 >6HQA-J nrPDB Length = 553 Score = 27.8 bits (60), Expect = 9.7, Method: Composition-based stats. Identities = 16/42 (38%), Positives = 26/42 (61%), Gaps = 4/42 (9%) Query: 8 ITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEAL 49 I T++ E+E V++ V +DIEG+ +DD + D+EE L Sbjct: 431 IATKQKERE---EQRVQKRVTLDIEGQ-EDDGKSKQDNEEVL 468 >5UJS-A nrPDB Length = 442 Score = 27.8 bits (60), Expect = 10.0, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 21/37 (56%) Query: 14 EQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALE 50 E E+V EV +D ++I+G D+ E+ D E LE Sbjct: 211 EPEVVQLCEVLKDAGLEIKGIGTDELEIYGSDGELLE 247 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.130 0.368 Lambda K H 0.267 0.0401 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,673,930 Number of Sequences: 36641 Number of extensions: 737063 Number of successful extensions: 3126 Number of sequences better than 10.0: 144 Number of HSP's better than 10.0 without gapping: 120 Number of HSP's successfully gapped in prelim test: 91 Number of HSP's that attempted gapping in prelim test: 2156 Number of HSP's gapped (non-prelim): 675 length of query: 431 length of database: 10,336,785 effective HSP length: 100 effective length of query: 331 effective length of database: 6,672,685 effective search space: 2208658735 effective search space used: 2208658735 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 60 (27.8 bits)