BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P34947 (590 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4TNB-A nrPDB 1221 0.0 3NYO-A nrPDB 826 0.0 4YHJ-A nrPDB 777 0.0 3C51-A nrPDB 493 e-140 5UUU-A nrPDB 310 8e-85 3PVW-A nrPDB 310 1e-84 2JDO-A nrPDB 209 2e-54 4RA4-A nrPDB 209 3e-54 3MV5-A nrPDB 207 1e-53 5KCV-A nrPDB 207 1e-53 3PFQ-A nrPDB 204 7e-53 2I0E-A nrPDB 204 9e-53 4L42-A nrPDB 196 2e-50 3A8W-A nrPDB 196 3e-50 3TXO-A nrPDB 194 7e-50 4RLP-A nrPDB 194 1e-49 1VZO-A nrPDB 193 2e-49 5F9E-A nrPDB 190 2e-48 4OTD-A nrPDB 189 2e-48 2Z7Q-A nrPDB 187 8e-48 4CRS-A nrPDB 187 1e-47 3HDN-A nrPDB 185 5e-47 5D9K-A nrPDB 184 6e-47 4FR4-A nrPDB 181 9e-46 4WB7-A nrPDB 179 4e-45 1FOT-A nrPDB 178 6e-45 5X3F-B nrPDB 177 2e-44 5N23-A nrPDB 176 2e-44 3ORZ-A nrPDB 171 7e-43 6BDL-A nrPDB 162 5e-40 6ED6-A nrPDB 161 8e-40 6E9W-A nrPDB 160 1e-39 5DYK-A nrPDB 158 8e-39 3TKU-A nrPDB 156 2e-38 5FET-A nrPDB 155 6e-38 5LOH-A nrPDB 154 2e-37 4AW2-A nrPDB 150 2e-36 2VD5-A nrPDB 148 6e-36 4C0T-A nrPDB 142 4e-34 2JC6-A nrPDB 140 1e-33 1ZWS-A nrPDB 130 2e-30 2A27-A nrPDB 130 2e-30 3GUB-A nrPDB 128 5e-30 6BXI-A nrPDB 128 6e-30 4LQP-A nrPDB 128 9e-30 2YAB-A nrPDB 127 1e-29 3MA6-A nrPDB 126 3e-29 2J90-A nrPDB 126 3e-29 2JAM-A nrPDB 125 7e-29 5JN2-A nrPDB 125 7e-29 3TAC-A nrPDB 121 7e-28 3DXN-A nrPDB 121 9e-28 5XZW-A nrPDB 121 1e-27 4FG9-A nrPDB 121 1e-27 3HZT-A nrPDB 121 1e-27 1KOB-A nrPDB 120 2e-27 4FIE-A nrPDB 119 3e-27 4XBR-A nrPDB 119 5e-27 2Q0N-A nrPDB 119 5e-27 4JDH-A nrPDB 118 6e-27 4PDS-A nrPDB 117 1e-26 4RGJ-A nrPDB 117 1e-26 3DFA-A nrPDB 116 3e-26 4YZB-A nrPDB 116 3e-26 3NCG-A nrPDB 116 3e-26 2Y7J-A nrPDB 114 9e-26 4B6L-A nrPDB 113 2e-25 2X4F-A nrPDB 113 2e-25 5JZN-A nrPDB 113 3e-25 3LIJ-A nrPDB 111 8e-25 2F57-A nrPDB 110 2e-24 3LM0-A nrPDB 110 2e-24 4I6B-A nrPDB 109 3e-24 3Q5I-A nrPDB 108 5e-24 5ES1-A nrPDB 108 5e-24 1PHK-A nrPDB 108 5e-24 2YCR-A nrPDB 108 7e-24 3I6U-A nrPDB 107 1e-23 3H4J-B nrPDB 107 1e-23 4D28-A nrPDB 107 2e-23 3D2K-A nrPDB 107 2e-23 4REW-A nrPDB 107 2e-23 5TQX-A nrPDB 106 3e-23 4CFH-A nrPDB 106 3e-23 4JXF-A nrPDB 105 4e-23 5FG8-A nrPDB 105 5e-23 5KZ7-A nrPDB 105 6e-23 6CMJ-A nrPDB 105 6e-23 4RED-A nrPDB 105 6e-23 2WQN-A nrPDB 104 8e-23 5IG1-A nrPDB 104 1e-22 6C9D-A nrPDB 103 2e-22 2HAK-A nrPDB 103 2e-22 5EZV-A nrPDB 103 3e-22 4CZT-A nrPDB 102 3e-22 4CFF-A nrPDB 102 4e-22 4KIK-B nrPDB 102 5e-22 1KOA-A nrPDB 101 8e-22 5YKS-A nrPDB 101 8e-22 2QNJ-A nrPDB 101 1e-21 3UTO-A nrPDB 101 1e-21 2YZA-A nrPDB 100 2e-21 3KK8-A nrPDB 100 2e-21 2W4O-A nrPDB 100 3e-21 2BDW-A nrPDB 99 4e-21 5YV8-A nrPDB 99 7e-21 4MVF-A nrPDB 98 8e-21 3MN3-A nrPDB 98 9e-21 4YNZ-A nrPDB 98 9e-21 4KS7-A nrPDB 97 1e-20 2VN9-A nrPDB 97 1e-20 4UZD-A nrPDB 97 1e-20 4NIF-A nrPDB 97 1e-20 3BHH-A nrPDB 97 1e-20 3ZDU-A nrPDB 97 2e-20 4B8L-A nrPDB 97 2e-20 4CQG-A nrPDB 97 2e-20 5DBX-A nrPDB 97 2e-20 3Q53-A nrPDB 97 2e-20 6FDY-U nrPDB 96 3e-20 3QA8-A nrPDB 96 3e-20 2VZ6-A nrPDB 96 4e-20 3KN6-A nrPDB 96 5e-20 5U6Y-A nrPDB 96 5e-20 3DB8-A nrPDB 96 6e-20 4WNO-A nrPDB 95 7e-20 6FD3-A nrPDB 95 8e-20 2V7O-A nrPDB 95 8e-20 4D2V-A nrPDB 95 1e-19 2OU7-A nrPDB 94 1e-19 3DAK-A nrPDB 94 1e-19 4JG6-A nrPDB 94 1e-19 5J5T-A nrPDB 94 1e-19 4J52-A nrPDB 94 2e-19 4APC-A nrPDB 93 2e-19 3F3Z-A nrPDB 93 3e-19 4KRC-A nrPDB 92 5e-19 3SOA-A nrPDB 92 6e-19 3IS5-A nrPDB 92 8e-19 6DTL-A nrPDB 92 9e-19 4QMW-A nrPDB 91 1e-18 2BPM-A nrPDB 91 1e-18 4BBM-A nrPDB 91 2e-18 4BGQ-A nrPDB 91 2e-18 1CM8-A nrPDB 90 2e-18 5WAX-A nrPDB 90 3e-18 3COM-A nrPDB 89 4e-18 6QAU-A nrPDB 89 4e-18 2XIK-A nrPDB 89 5e-18 6CCF-A nrPDB 89 5e-18 1TKI-A nrPDB 89 8e-18 4AF3-A nrPDB 88 1e-17 3FXW-A nrPDB 87 1e-17 4LG4-A nrPDB 87 1e-17 5G6V-A nrPDB 87 2e-17 3NIZ-A nrPDB 87 2e-17 6AO5-A nrPDB 87 2e-17 3E7O-A nrPDB 87 3e-17 2HW6-A nrPDB 86 3e-17 3GC9-A nrPDB 86 6e-17 4FZF-B nrPDB 85 1e-16 6CKI-A nrPDB 84 1e-16 4AGU-A nrPDB 84 1e-16 3UC3-A nrPDB 84 2e-16 5D7A-A nrPDB 84 2e-16 3UDB-A nrPDB 84 2e-16 6E2O-A nrPDB 83 3e-16 1G3N-A nrPDB 82 5e-16 1S9I-A nrPDB 82 7e-16 1V0B-A nrPDB 82 8e-16 6HXF-B nrPDB 82 8e-16 5EFQ-A nrPDB 82 1e-15 1JNK-A nrPDB 81 1e-15 3OHT-A nrPDB 81 1e-15 5AWM-A nrPDB 81 1e-15 4MYG-A nrPDB 81 1e-15 6J5U-C nrPDB 81 1e-15 3FI2-A nrPDB 81 1e-15 5TUR-A nrPDB 81 2e-15 5VD3-A nrPDB 80 2e-15 5Y86-A nrPDB 80 2e-15 3ZUT-A nrPDB 80 2e-15 4EWQ-A nrPDB 80 2e-15 1NY3-A nrPDB 80 3e-15 2OZA-A nrPDB 80 3e-15 1UA2-A nrPDB 80 3e-15 4NST-A nrPDB 80 3e-15 3KA0-A nrPDB 80 3e-15 4CSV-A nrPDB 79 4e-15 2XS0-A nrPDB 79 4e-15 4RC3-A nrPDB 79 4e-15 2PMN-X nrPDB 79 4e-15 5ZTN-A nrPDB 79 5e-15 2BRG-A nrPDB 79 6e-15 2XNP-A nrPDB 79 6e-15 3BGP-A nrPDB 79 6e-15 2A1A-B nrPDB 79 6e-15 5B2L-A nrPDB 79 7e-15 4O2Z-A nrPDB 79 7e-15 5TOS-A nrPDB 78 8e-15 6GU6-A nrPDB 77 1e-14 4IDT-A nrPDB 77 1e-14 4QTB-A nrPDB 77 2e-14 4EQM-A nrPDB 77 2e-14 4HVI-A nrPDB 77 2e-14 3UIU-A nrPDB 77 2e-14 3LLT-A nrPDB 76 3e-14 5Z33-A nrPDB 76 4e-14 5AIR-A nrPDB 76 4e-14 4E93-A nrPDB 76 4e-14 5KKR-C nrPDB 76 5e-14 3VN9-A nrPDB 76 5e-14 2PL0-A nrPDB 75 5e-14 3EQC-A nrPDB 75 6e-14 2F9G-A nrPDB 75 8e-14 1ZXE-A nrPDB 75 8e-14 5NGU-A nrPDB 75 1e-13 2DQ7-X nrPDB 75 1e-13 4AN9-A nrPDB 74 1e-13 3FME-A nrPDB 74 1e-13 4QNY-A nrPDB 74 1e-13 5HI2-A nrPDB 74 2e-13 4U41-A nrPDB 74 2e-13 4X7Q-B nrPDB 74 2e-13 4G3E-A nrPDB 74 2e-13 3ALO-A nrPDB 74 2e-13 5L2Q-C nrPDB 74 2e-13 4XLV-A nrPDB 73 3e-13 2W96-B nrPDB 73 3e-13 2UV2-A nrPDB 73 3e-13 6CTH-A nrPDB 73 4e-13 6GVJ-A nrPDB 72 5e-13 3HKO-A nrPDB 72 5e-13 4GS6-A nrPDB 72 6e-13 4AU8-A nrPDB 72 7e-13 4UYA-A nrPDB 72 1e-12 5UIU-A nrPDB 71 1e-12 6F3F-A nrPDB 71 1e-12 5HIE-A nrPDB 71 2e-12 6CQF-A nrPDB 70 2e-12 3CJF-A nrPDB 70 2e-12 3MIA-A nrPDB 70 2e-12 2H8H-A nrPDB 70 2e-12 5AMN-A nrPDB 70 2e-12 2WO6-A nrPDB 70 2e-12 3QUP-A nrPDB 70 2e-12 3OMV-A nrPDB 70 3e-12 4NEU-A nrPDB 70 3e-12 3UIM-A nrPDB 70 3e-12 3HMP-A nrPDB 69 4e-12 2BUJ-A nrPDB 69 4e-12 5AP3-A nrPDB 69 6e-12 4IC8-A nrPDB 69 6e-12 6DBM-A nrPDB 69 7e-12 4ZSG-A nrPDB 69 7e-12 3DLS-A nrPDB 69 7e-12 5SYS-A nrPDB 68 1e-11 2H34-A nrPDB 68 1e-11 6FER-A nrPDB 68 1e-11 6HMD-A nrPDB 68 1e-11 5VO2-A nrPDB 68 1e-11 4YFF-A nrPDB 67 1e-11 6FEX-A nrPDB 67 2e-11 3I81-A nrPDB 67 2e-11 6EII-A nrPDB 67 2e-11 4MD7-E nrPDB 67 2e-11 3A4O-X nrPDB 67 3e-11 5WNO-A nrPDB 67 3e-11 2ZMD-A nrPDB 66 3e-11 2XYN-A nrPDB 66 4e-11 4OLI-A nrPDB 66 4e-11 5XVU-A nrPDB 66 4e-11 1U59-A nrPDB 66 4e-11 4XEY-B nrPDB 66 5e-11 5EG3-A nrPDB 66 5e-11 3ORP-A nrPDB 66 5e-11 2HK5-A nrPDB 65 6e-11 6NPU-A nrPDB 65 6e-11 1FVR-A nrPDB 65 6e-11 4M7I-A nrPDB 65 7e-11 2OZO-A nrPDB 65 7e-11 3C1X-A nrPDB 65 7e-11 4IAN-A nrPDB 65 8e-11 6O6Q-A nrPDB 65 1e-10 4UY9-A nrPDB 65 1e-10 4JLC-A nrPDB 65 1e-10 4E7W-A nrPDB 64 1e-10 4PL5-B nrPDB 64 1e-10 5U6B-A nrPDB 64 1e-10 3E3P-A nrPDB 64 2e-10 1AD5-A nrPDB 64 2e-10 2RIO-A nrPDB 64 2e-10 5H2U-A nrPDB 64 2e-10 4C59-A nrPDB 64 2e-10 5HLW-A nrPDB 64 2e-10 2QKW-B nrPDB 64 2e-10 2FO0-A nrPDB 64 3e-10 3KRL-A nrPDB 63 4e-10 4E20-A nrPDB 63 4e-10 3GQL-A nrPDB 63 4e-10 3OZ6-A nrPDB 63 4e-10 3BEA-A nrPDB 63 4e-10 5A46-A nrPDB 63 4e-10 3ZBF-A nrPDB 63 4e-10 2PSQ-A nrPDB 63 4e-10 3TT0-A nrPDB 62 5e-10 4PWN-A nrPDB 62 6e-10 4OW8-A nrPDB 62 6e-10 5FM2-A nrPDB 62 6e-10 3GC0-A nrPDB 62 6e-10 1JPA-A nrPDB 62 6e-10 4K33-A nrPDB 62 7e-10 1K9A-A nrPDB 62 7e-10 4X3F-A nrPDB 62 7e-10 4EUT-A nrPDB 62 7e-10 2WTK-C nrPDB 62 7e-10 2OGV-A nrPDB 62 7e-10 1BYG-A nrPDB 62 8e-10 6BSD-A nrPDB 62 8e-10 6NT9-A nrPDB 62 8e-10 2R2P-A nrPDB 62 9e-10 3PPZ-A nrPDB 62 9e-10 4EUU-A nrPDB 62 1e-09 5U6C-A nrPDB 61 1e-09 6HV0-A nrPDB 61 1e-09 5LPZ-A nrPDB 61 1e-09 5LPV-A nrPDB 61 1e-09 4CRL-A nrPDB 61 1e-09 3DTC-A nrPDB 61 1e-09 6B2Q-A nrPDB 61 1e-09 6O8B-A nrPDB 61 2e-09 2W1I-A nrPDB 60 2e-09 5GRN-A nrPDB 60 2e-09 5HVK-A nrPDB 60 2e-09 6FYV-A nrPDB 60 2e-09 2I6L-A nrPDB 60 2e-09 2PVN-A nrPDB 60 2e-09 6DBN-A nrPDB 60 2e-09 5X02-A nrPDB 60 2e-09 1LUF-A nrPDB 60 3e-09 4XUF-A nrPDB 60 3e-09 3IO7-A nrPDB 60 3e-09 3M42-A nrPDB 60 3e-09 5X5O-A nrPDB 60 3e-09 3QGY-A nrPDB 60 4e-09 4FL3-A nrPDB 60 4e-09 3VHK-A nrPDB 59 4e-09 2VWV-A nrPDB 59 5e-09 3DKO-A nrPDB 59 5e-09 4R7H-A nrPDB 59 6e-09 2GCD-A nrPDB 59 6e-09 6GQK-A nrPDB 59 6e-09 5C26-A nrPDB 59 6e-09 1U5R-A nrPDB 59 6e-09 3RAW-A nrPDB 59 7e-09 4TPT-A nrPDB 58 1e-08 3SOC-A nrPDB 58 1e-08 3PP0-A nrPDB 58 1e-08 2Y6O-A nrPDB 58 1e-08 3ZZW-A nrPDB 58 1e-08 3PLS-A nrPDB 57 2e-08 3RP9-A nrPDB 57 2e-08 3PG1-A nrPDB 57 2e-08 4AT3-A nrPDB 57 2e-08 5X8I-B nrPDB 57 2e-08 5TE0-A nrPDB 57 2e-08 4EBW-A nrPDB 57 3e-08 3QD2-B nrPDB 56 3e-08 2J0K-A nrPDB 56 3e-08 3AOX-A nrPDB 56 4e-08 6BFN-A nrPDB 56 4e-08 4M66-A nrPDB 56 4e-08 4Y93-A nrPDB 56 4e-08 4Y83-A nrPDB 56 5e-08 4XCU-A nrPDB 56 5e-08 4H1J-A nrPDB 55 6e-08 6E4F-A nrPDB 55 6e-08 2JD5-A nrPDB 55 7e-08 3BBT-B nrPDB 55 7e-08 4RT7-A nrPDB 55 8e-08 4P5Q-A nrPDB 55 8e-08 3HNG-A nrPDB 55 9e-08 5IKW-A nrPDB 55 9e-08 5O0Y-A nrPDB 55 1e-07 4XI2-A nrPDB 55 1e-07 5UNP-A nrPDB 54 2e-07 3N9X-A nrPDB 54 2e-07 4LFI-A nrPDB 54 3e-07 3G0E-A nrPDB 54 3e-07 6DC0-A nrPDB 53 4e-07 5GNK-A nrPDB 53 4e-07 3MY0-A nrPDB 53 4e-07 5L6P-A nrPDB 53 5e-07 5CEK-A nrPDB 53 5e-07 3SXS-A nrPDB 53 5e-07 3KUL-B nrPDB 52 5e-07 4HZS-A nrPDB 52 6e-07 3V5Q-A nrPDB 52 6e-07 3LZB-A nrPDB 52 7e-07 1U54-B nrPDB 52 7e-07 4PDO-A nrPDB 52 7e-07 2QLU-A nrPDB 52 9e-07 5WNL-A nrPDB 52 9e-07 3NIE-A nrPDB 52 9e-07 5MJB-A nrPDB 50 3e-06 5AR8-A nrPDB 50 3e-06 3LMG-A nrPDB 50 3e-06 4BTK-A nrPDB 50 4e-06 4NFN-A nrPDB 49 4e-06 5XD6-A nrPDB 49 5e-06 5VDK-A nrPDB 49 7e-06 2PZI-A nrPDB 47 2e-05 4LRM-A nrPDB 47 2e-05 3EB0-A nrPDB 47 2e-05 5KMM-A nrPDB 47 2e-05 4Y12-A nrPDB 47 2e-05 2CMW-A nrPDB 47 3e-05 5DMZ-A nrPDB 46 4e-05 1PY5-A nrPDB 46 4e-05 4L68-A nrPDB 46 4e-05 3Q4U-A nrPDB 46 5e-05 5X18-A nrPDB 46 6e-05 2Y4I-B nrPDB 45 7e-05 3MDY-A nrPDB 45 7e-05 5E8V-A nrPDB 45 9e-05 2C47-A nrPDB 45 1e-04 3G2F-A nrPDB 44 2e-04 4NT4-A nrPDB 44 2e-04 4XHH-A nrPDB 44 2e-04 3SV0-A nrPDB 44 3e-04 2CHL-A nrPDB 44 3e-04 6EQI-C nrPDB 43 3e-04 4TN6-A nrPDB 42 8e-04 4XHL-A nrPDB 42 0.001 5VC6-A nrPDB 41 0.001 4F9B-A nrPDB 41 0.001 5OAT-A nrPDB 41 0.001 5FQD-C nrPDB 41 0.002 5CLR-A nrPDB 40 0.003 6J6I-B nrPDB 39 0.006 1CSN-A nrPDB 39 0.006 3REP-A nrPDB 37 0.019 2X7G-A nrPDB 37 0.025 4I94-A nrPDB 36 0.051 4JRN-A nrPDB 36 0.060 2RSV-A nrPDB 35 0.080 4O1O-A nrPDB 35 0.10 2LAV-A nrPDB 35 0.11 4CYJ-A nrPDB 35 0.13 1R6K-A nrPDB 34 0.16 4IX6-A nrPDB 33 0.45 6EWX-A nrPDB 33 0.48 4WUA-A nrPDB 32 0.79 4AZV-A nrPDB 32 1.1 5M07-A nrPDB 31 1.2 2IHB-B nrPDB 31 1.5 6BHC-A nrPDB 31 1.6 6G4J-A nrPDB 31 1.8 4AZW-A nrPDB 31 1.8 2I59-A nrPDB 31 1.9 5VE6-A nrPDB 29 5.8 4V6W-AT nrPDB 29 7.0 >4TNB-A nrPDB Length = 590 Score = 1221 bits (3159), Expect = 0.0, Method: Compositional matrix adjust. Identities = 587/590 (99%), Positives = 588/590 (99%) Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ Sbjct: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60 Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGK+IMTKYLTPKSPVFIAQ Sbjct: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKKIMTKYLTPKSPVFIAQ 120 Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP Sbjct: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180 Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 DLH ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC Sbjct: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480 KMLLTKDAKQRLGCQEE AAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI Sbjct: 421 KMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480 Query: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN 540 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN Sbjct: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN 540 Query: 541 HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS 590 HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS Sbjct: 541 HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS 590 >3NYO-A nrPDB Length = 576 Score = 826 bits (2134), Expect = 0.0, Method: Compositional matrix adjust. Identities = 403/558 (72%), Positives = 470/558 (84%), Gaps = 1/558 (0%) Query: 2 ELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQP 61 ELENIVANTVLLKAREGGGG RKGKSKKW+++L+FPHISQCE+LR +++RDY SLC++QP Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQP 61 Query: 62 IGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQV 121 IGRLLFR+FC TRP L + FLD VAEYEVTPD+K G+++ +L+ P I +V Sbjct: 62 IGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEV 121 Query: 122 GQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPV 181 + LV+ ++L Q PCK+LF + HEYL PF +YLDS++F+RFLQWKWLERQPV Sbjct: 122 PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPV 181 Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK+LEKKRIKKRKGE+MALNEKQILEKV Sbjct: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 NS+FVV+LAYAYETKDALCLVLT+MNGGDLKFHIY+MG GF E RA+FYAAEI CGLED Sbjct: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 LHRE VYRDLKPENILLDD+GHIRISDLGLAV +PEG I+GRVGTVGYMAPEV+ N+R Sbjct: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 Y SPD+W LGCL+YEMI GQSPF+ RK+K+KREEV+R V E E YS +FS +A+S+C Sbjct: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIE 481 LL KD +RLGC+ A EVK HP F+ +NFKRL AGML+PPF PDP+A+YCKDVLDIE Sbjct: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE 481 Query: 482 QFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLN-RN 540 QFSTVKGV L+ TD DFY KF+TGSV IPWQNEM+ETECF+ELNVFG +G++PPDL+ + Sbjct: 482 QFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKG 541 Query: 541 HPPEPPKKGLLQRLFKRQ 558 PP PPKKGLLQRLF RQ Sbjct: 542 QPPAPPKKGLLQRLFSRQ 559 >4YHJ-A nrPDB Length = 584 Score = 777 bits (2006), Expect = 0.0, Method: Compositional matrix adjust. Identities = 381/560 (68%), Positives = 458/560 (81%), Gaps = 3/560 (0%) Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60 MELENIVAN++LLKAR+GG GK+ G+SKKWKEIL P +SQC +LR +I++DY SLCDKQ Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60 Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120 PIGR LFRQFC+T+P L+ +I+FLD+VAEYEV DE + G I+ ++ K + + Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120 Query: 121 VGQDLVSQTEEKLLQK-PCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179 + D+V++ L ++ P K+ F C + H YLRGEPF EY +S +F +FLQWKWLERQ Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180 Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACK+L+KKRIKKRKGE+MALNEK+ILE Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 KV S+FVV+LAYAYETKDALCLVLTIMNGGDLKFHIYN+GNPGF+E+RA+FYAAE+ CGL Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 EDL RE VYRDLKPENILLDD GHIRISDLGLA +IPEG +RGRVGTVGYMAPEV+NN Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 ++Y SPD+WGLGCLIYEMI+G SPF+ KEKVK EEVD+R+ E YS KFSE+AKSI Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479 C+MLLTK+ +RLGC+ EGAA VK+HP F+++NF+RLEA ML+PPF PDP AVYCKDVLD Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480 Query: 480 IEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNR 539 IEQFS VKG+ LD D+DFY++F+TG VSIPWQNEMIE+ CFK++N LP DL++ Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540 Query: 540 N--HPPEPPKKGLLQRLFKR 557 N P P +G RLF+R Sbjct: 541 NIHTPVSRPNRGFFYRLFRR 560 >3C51-A nrPDB Length = 543 Score = 493 bits (1270), Expect = e-140, Method: Compositional matrix adjust. Identities = 254/536 (47%), Positives = 361/536 (67%), Gaps = 11/536 (2%) Query: 3 LENIVANTVLLKAREGGGGKRKG---KSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDK 59 LE +VAN+ + AR G G + +K+ LK P +S+CE LR ++D + +C + Sbjct: 6 LETVVANSAFIAAR-GSFDASSGPASRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLE 64 Query: 60 QPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIA 119 QPIG+ LF+QF T +Q + +Y+ D +K + + YL P++ +F + Sbjct: 65 QPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCS 124 Query: 120 QVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179 + + V++ LF ++V +L PF E+LDS++F RFLQWKWLE Q Sbjct: 125 FLDAETVARARAG----AGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQ 180 Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P+ ++ F +RVLG+GGFGEV ACQ++ATGK+YACK+L KKR+KKRKG A+ EK+IL Sbjct: 181 PMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILA 240 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALFYAAEILC 297 KV+S+F+V+LAYA+ETK LCLV+TIMNGGD+++HIYN+ NPGF+E RA+FY A+I+ Sbjct: 241 KVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS 300 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-IRGRVGTVGYMAPEV 356 GLE LH+ N +YRDLKPEN+LLDD G++RISDLGLAV++ G +G GT G+MAPE+ Sbjct: 301 GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL 360 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 L + Y S DY+ LG +YEMI + PFR R EKV+ +E+ +RVLE Y KFS + Sbjct: 361 LLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPAS 420 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKD 476 K C+ LL KD ++RLG ++ ++ HP FR++++++LEAGML PPFVPD R VY K+ Sbjct: 421 KDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKN 480 Query: 477 VLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGT 532 + D+ FSTVKGV + D +F+ +F++G+ IPWQ EMIET F +LNV+ P+G Sbjct: 481 IQDVGAFSTVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDGV 536 >5UUU-A nrPDB Length = 547 Score = 310 bits (795), Expect = 8e-85, Method: Compositional matrix adjust. Identities = 188/481 (39%), Positives = 271/481 (56%), Gaps = 24/481 (4%) Query: 60 QPIGRLLFRQFC-----ETRPGLECYIQFLDSVAEYE-VTPDEKLGEKGKEIMTKYLTPK 113 Q +G LLFR FC E RP ++F + + +YE + +E+ + +EI Y+ + Sbjct: 70 QKLGYLLFRDFCLNHLEEARP----LVEFYEEIKKYEKLETEEERVARSREIFDSYIMKE 125 Query: 114 SPVFIAQVGQDLVSQTEEKLLQKPCK-ELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQ 172 + + L +K +LF + + + LRG+ F ++++S F RF Q Sbjct: 126 LLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQ 185 Query: 173 WKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231 WK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE++A Sbjct: 186 WKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 245 Query: 232 LNEKQILEKVNS---QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA 288 LNE+ +L V++ F+V ++YA+ T D L +L +MNGGDL +H+ G F E Sbjct: 246 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADM 303 Query: 289 LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT 348 FYAAEI+ GLE +H VYRDLKP NILLD++GH+RISDLGLA + VGT Sbjct: 304 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGT 362 Query: 349 VGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 GYMAPEVL Y S D++ LGC++++++ G SPFR K K K E+DR L Sbjct: 363 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVE 421 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 FS E +S+ + LL +D +RLGC GA EVK PFFR+++++ + PP +P Sbjct: 422 LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 481 Query: 468 DPRAVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELN 525 V D DI F KG+ L +D + Y F ++S WQ E+ ET F +N Sbjct: 482 PRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTIN 539 Query: 526 V 526 Sbjct: 540 A 540 >3PVW-A nrPDB Length = 695 Score = 310 bits (793), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 202/542 (37%), Positives = 295/542 (54%), Gaps = 30/542 (5%) Query: 2 ELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSL--CDK 59 +LE ++A+ L A E ++ K K +L P I + DR + Sbjct: 3 DLEAVLADVSYLMAMEKSKATPAARASK-KILLPEPSIRSVMQ-KYLEDRGEVTFEKIFS 60 Query: 60 QPIGRLLFRQFC-----ETRPGLECYIQFLDSVAEYEV--TPDEKLGEKGKEIMTKYLTP 112 Q +G LLFR FC E +P ++F + + +YE T +E+L +EI Y+ Sbjct: 61 QKLGYLLFRDFCLKHLEEAKP----LVEFYEEIKKYEKLETEEERLV-CSREIFDTYIMK 115 Query: 113 KSPVFIAQVGQDLVSQTEEKLLQKPCK-ELFSACAQSVHEYLRGEPFHEYLDSMFFDRFL 171 + + + + L++K +LF + + + LRG+ F ++++S F RF Sbjct: 116 ELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFC 175 Query: 172 QWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM 230 QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE++ Sbjct: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 Query: 231 ALNEKQILEKVNS---QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEER 287 ALNE+ +L V++ F+V ++YA+ T D L +L +MNGGDL +H+ G F E Sbjct: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEAD 293 Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG 347 FYAAEI+ GLE +H VYRDLKP NILLD++GH+RISDLGLA + VG Sbjct: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVG 352 Query: 348 TVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEE 406 T GYMAPEVL Y S D++ LGC++++++ G SPFR K K K E+DR L Sbjct: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAV 411 Query: 407 VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFV 466 FS E +S+ + LL +D +RLGC GA EVK PFFR+++++ + PP + Sbjct: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLI 471 Query: 467 PDPRAVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKEL 524 P V D DI F KG+ L +D + Y F ++S WQ E+ ET F + Sbjct: 472 PPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTI 529 Query: 525 NV 526 N Sbjct: 530 NA 531 >2JDO-A nrPDB Length = 342 Score = 209 bits (533), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 119/288 (41%), Positives = 167/288 (57%), Gaps = 7/288 (2%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 VT N F ++LGKG FG+V + +ATG+ YA K L K+ I + + + E ++L+ Sbjct: 7 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 66 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 F+ L YA++T D LC V+ NGG+L FH+ F EERA FY AEI+ LE Sbjct: 67 TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVSALE 124 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNN 359 LH + VYRD+K EN++LD GHI+I+D GL + I +G ++ GT Y+APEVL + Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 184 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 YG + D+WGLG ++YEM+ G+ PF + E + +L E + S EAKS+ Sbjct: 185 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHERLFELILMEEIRFPRTLSPEAKSL 240 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 LL KD KQRLG A EV H FF ++N++ + L PPF P Sbjct: 241 LAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 288 >4RA4-A nrPDB Length = 355 Score = 209 bits (532), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 117/294 (39%), Positives = 174/294 (59%), Gaps = 10/294 (3%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 L+R +T F VLGKG FG+V + T ++YA K L+K + + + EK Sbjct: 14 LDRVKLTDFNFLM--VLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK 71 Query: 236 QILEKVNSQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 ++L ++ F+ L ++T D L V+ +NGGDL +HI +G F+E +A+FYAAE Sbjct: 72 RVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAE 129 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMA 353 I GL LH+ +YRDLK +N++LD GHI+I+D G+ + + +G R GT Y+A Sbjct: 130 ISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIA 189 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 PE++ Q YG S D+W G L+YEM+ GQ PF G E +E+ + ++E Y S Sbjct: 190 PEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKSLS 245 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 +EA SICK L+TK +RLGC EG +V+ H FFR +++++LE + PPF P Sbjct: 246 KEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP 299 >3MV5-A nrPDB Length = 342 Score = 207 bits (527), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 118/289 (40%), Positives = 169/289 (58%), Gaps = 8/289 (2%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + + L E ++L+ Sbjct: 7 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 66 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 F+ L Y+++T D LC V+ NGG+L FH+ F E+RA FY AEI+ L+ Sbjct: 67 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 124 Query: 301 DLHRE-NTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358 LH E N VYRDLK EN++LD GHI+I+D GL + I +G ++ GT Y+APEVL Sbjct: 125 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 184 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + YG + D+WGLG ++YEM+ G+ PF + E++ +L E + EAKS Sbjct: 185 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPEAKS 240 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 + LL KD KQRLG E A E+ +H FF + ++ + L PPF P Sbjct: 241 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 289 >5KCV-A nrPDB Length = 460 Score = 207 bits (526), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 118/289 (40%), Positives = 169/289 (58%), Gaps = 8/289 (2%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + + L E ++L+ Sbjct: 159 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 218 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 F+ L Y+++T D LC V+ NGG+L FH+ F E+RA FY AEI+ L+ Sbjct: 219 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 276 Query: 301 DLHRE-NTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358 LH E N VYRDLK EN++LD GHI+I+D GL + I +G ++ GT Y+APEVL Sbjct: 277 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 336 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + YG + D+WGLG ++YEM+ G+ PF + E++ +L E + EAKS Sbjct: 337 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPEAKS 392 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 + LL KD KQRLG E A E+ +H FF + ++ + L PPF P Sbjct: 393 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 441 >3PFQ-A nrPDB Length = 674 Score = 204 bits (520), Expect = 7e-53, Method: Compositional matrix adjust. Identities = 111/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE-KVNSQ 244 F VLGKG FG+V + + T ++YA K L+K + + + EK++L Sbjct: 343 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 402 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 F+ L ++T D L V+ +NGGDL +HI +G F+E A+FYAAEI GL L Sbjct: 403 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 460 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 + +YRDLK +N++LD GHI+I+D G+ + I +G + GT Y+APE++ Q YG Sbjct: 461 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 520 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 S D+W G L+YEM+ GQ+PF G E +E+ + ++E Y S+EA +ICK L Sbjct: 521 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 576 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 +TK +RLGC EG ++K H FFR +++++LE + PP+ P Sbjct: 577 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 620 >2I0E-A nrPDB Length = 353 Score = 204 bits (519), Expect = 9e-53, Method: Compositional matrix adjust. Identities = 111/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ- 244 F VLGKG FG+V + + T ++YA K L+K + + + EK++L Sbjct: 22 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 81 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 F+ L ++T D L V+ +NGGDL +HI +G F+E A+FYAAEI GL L Sbjct: 82 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 139 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 + +YRDLK +N++LD GHI+I+D G+ + I +G + GT Y+APE++ Q YG Sbjct: 140 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 199 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 S D+W G L+YEM+ GQ+PF G E +E+ + ++E Y S+EA +ICK L Sbjct: 200 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 255 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 +TK +RLGC EG ++K H FFR +++++LE + PP+ P Sbjct: 256 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 299 >4L42-A nrPDB Length = 346 Score = 196 bits (498), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 120/325 (36%), Positives = 184/325 (56%), Gaps = 22/325 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRA-----TGKMYACKRLEKKRI-KKRKGESMALNEKQILE 239 F RVLGKGG+G+V QVR TGK++A K L+K I + K + E+ ILE Sbjct: 20 FELLRVLGKGGYGKVF--QVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 77 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +V F+V+L YA++T L L+L ++GG+L + G F E+ A FY AEI L Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI--FMEDTACFYLAEISMAL 135 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358 LH++ +YRDLKPENI+L+ GH++++D GL + I +G + GT+ YMAPE+L Sbjct: 136 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + + D+W LG L+Y+M+ G PF G R++ ++L+ + ++EA+ Sbjct: 196 RSGHNRAVDWWSLGALMYDMLTGAPPFTGE----NRKKTIDKILKCKLNLPPYLTQEARD 251 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVL 478 + K LL ++A RLG A EV+ HPFFR++N++ L A ++PPF P + Sbjct: 252 LLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP-----LLQSEE 306 Query: 479 DIEQFST--VKGVNLDHTDDDFYSK 501 D+ QF + + +D DD S+ Sbjct: 307 DVSQFDSKFTRQTPVDSPDDSTLSE 331 >3A8W-A nrPDB Length = 345 Score = 196 bits (498), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 117/330 (35%), Positives = 179/330 (54%), Gaps = 12/330 (3%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P+ F RV+G+G + +V +++ T ++YA K ++K+ + + EK + E Sbjct: 5 PLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE 64 Query: 240 KV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + N F+V L ++T+ L V+ +NGGDL FH+ EE A FY+AEI Sbjct: 65 QASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRK--LPEEHARFYSAEISLA 122 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVL 357 L LH +YRDLK +N+LLD GHI+++D G+ + + GD GT Y+APE+L Sbjct: 123 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 182 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFR--GRKEKVKREEVD---RRVLETEEVYSHKF 412 + YG S D+W LG L++EM+ G+SPF G + + D + +LE + Sbjct: 183 RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSL 242 Query: 413 SEEAKSICKMLLTKDAKQRLGCQ-EEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRA 471 S +A S+ K L KD K+RLGC + G A+++ HPFFRN+++ +E + PPF P+ Sbjct: 243 SVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISG 302 Query: 472 VYCKDVLDIEQFSTVKGVNLDHTDDDFYSK 501 + D D QF T + V L DDD K Sbjct: 303 EFGLDNFD-SQF-TNEPVQLTPDDDDIVRK 330 >3TXO-A nrPDB Length = 353 Score = 194 bits (494), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 110/287 (38%), Positives = 160/287 (55%), Gaps = 9/287 (3%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-N 242 + F RVLGKG FG+V +V+ TG +YA K L+K I + + EK+IL N Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 F+ L ++T D L V+ +NGGDL FHI + F+E RA FYAAEI+ L L Sbjct: 83 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK--SRRFDEARARFYAAEIISALMFL 140 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQR 361 H + +YRDLK +N+LLD GH +++D G+ + I G GT Y+APE+L Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 200 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 YG + D+W +G L+YEM+ G +PF E +++ +L E VY E+A I K Sbjct: 201 YGPAVDWWAMGVLLYEMLCGHAPFEAENE----DDLFEAILNDEVVYPTWLHEDATGILK 256 Query: 422 MLLTKDAKQRLGCQEEGAAE-VKRHPFFRNMNFKRLEAGMLDPPFVP 467 +TK+ RLG +G + RHPFF+ +++ +L ++PPF P Sbjct: 257 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 303 >4RLP-A nrPDB Length = 288 Score = 194 bits (492), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 113/289 (39%), Positives = 171/289 (59%), Gaps = 15/289 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRA-----TGKMYACKRLEKKRI-KKRKGESMALNEKQILE 239 F RVLGKGG+G+V QVR TGK++A K L+K I + K + E+ ILE Sbjct: 7 FELLRVLGKGGYGKVF--QVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +V F+V+L YA++T L L+L ++GG+L + G F E+ A FY AEI L Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI--FMEDTACFYLAEISMAL 122 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358 LH++ +YRDLKPENI+L+ GH++++D GL + I +G + GT+ YMAPE+L Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + + D+W LG L+Y+M+ G PF G R++ ++L+ + ++EA+ Sbjct: 183 RSGHNRAVDWWSLGALMYDMLTGAPPFTGE----NRKKTIDKILKCKLNLPPYLTQEARD 238 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 + K LL ++A RLG A EV+ HPFFR++N++ L A ++PPF P Sbjct: 239 LLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >1VZO-A nrPDB Length = 355 Score = 193 bits (491), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 116/307 (37%), Positives = 170/307 (55%), Gaps = 16/307 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRA---TGKMYACKRLEKKRI-KKRKGESMALNEKQILEKV 241 F +VLG G +G+V + + TGK+YA K L+K I +K K E+Q+LE + Sbjct: 56 FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHI 115 Query: 242 -NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 S F+V L YA++T+ L L+L +NGG+L H+ F E Y EI+ LE Sbjct: 116 RQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQ--RERFTEHEVQIYVGEIVLALE 173 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR--VGTVGYMAPEVLN 358 LH+ +YRD+K ENILLD GH+ ++D GL+ + + R GT+ YMAP+++ Sbjct: 174 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIVR 233 Query: 359 NQRYGL--SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 G + D+W LG L+YE++ G SPF EK + E+ RR+L++E Y + S A Sbjct: 234 GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALA 293 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKD 476 K + + LL KD K+RLGC A E+K H FF+ +N+ L A + PF P +D Sbjct: 294 KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP-----VIRD 348 Query: 477 VLDIEQF 483 LD+ F Sbjct: 349 ELDVSNF 355 >5F9E-A nrPDB Length = 353 Score = 190 bits (482), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 106/290 (36%), Positives = 165/290 (56%), Gaps = 12/290 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ- 244 F +++LGKG FG+V + + T + +A K L+K + + EK++L Sbjct: 21 FELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP 80 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 F+ ++ ++TK+ L V+ +NGGDL +HI + F+ RA FYAAEI+ GL+ LH Sbjct: 81 FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK--FDLSRATFYAAEIILGLQFLHS 138 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV-GTVGYMAPEVLNNQRYG 363 + VYRDLK +NILLD GHI+I+D G+ + GD GT Y+APE+L Q+Y Sbjct: 139 KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYN 198 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 S D+W G L+YEM+ GQSPF G+ E EE+ + Y +EAK + L Sbjct: 199 HSVDWWSFGVLLYEMLIGQSPFHGQDE----EELFHSIRMDNPFYPRWLEKEAKDLLVKL 254 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVY 473 ++ ++RLG + ++++HP FR +N++ LE +DPPF P ++ + Sbjct: 255 FVREPEKRLGVR----GDIRQHPLFREINWEELERKEIDPPFRPKVKSPF 300 >4OTD-A nrPDB Length = 341 Score = 189 bits (481), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 119/296 (40%), Positives = 173/296 (58%), Gaps = 11/296 (3%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK Sbjct: 4 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 63 Query: 236 QILEKVNSQ---FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 +IL V S F+VNL ++T + +C V+ GGDL HI++ F E RA+FY+ Sbjct: 64 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 120 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGY 351 A ++ GL+ LH VYRDLK +N+LLD G+++I+D GL + + GD GT + Sbjct: 121 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 180 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 +APEVL + Y + D+WGLG L+YEM+ G+SPF G E EEV ++ E Y Sbjct: 181 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 236 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 S EA I + LL ++ ++RLG E A +VK+ PFFR + ++ L A L PPFVP Sbjct: 237 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 292 >2Z7Q-A nrPDB Length = 321 Score = 187 bits (476), Expect = 8e-48, Method: Compositional matrix adjust. Identities = 110/286 (38%), Positives = 160/286 (55%), Gaps = 11/286 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRA---TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 F +VLG+G FG+V + +G +YA K L+K +K R + E+ IL VN Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-ERDILADVN 88 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 FVV L YA++T+ L L+L + GGDL + F EE FY AE+ GL+ L Sbjct: 89 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALGLDHL 146 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQR 361 H +YRDLKPENILLD+ GHI+++D GL+ + I GTV YMAPEV+N Q Sbjct: 147 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 206 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 + S D+W G L++EM+ G PF+G+ R+E +L+ + S EA+S+ + Sbjct: 207 HSHSADWWSYGVLMFEMLTGSLPFQGK----DRKETMTLILKAKLGMPQFLSTEAQSLLR 262 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 L ++ RLG +GA E+KRH F+ +++ +L + PPF P Sbjct: 263 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 308 >4CRS-A nrPDB Length = 341 Score = 187 bits (474), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 120/290 (41%), Positives = 168/290 (57%), Gaps = 11/290 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS-- 243 FR VL +G FG+V + + T +M+A K L+K I R + EK+I E VNS Sbjct: 14 FRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR 73 Query: 244 -QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 F+VNL ++TK+ +C V+ GGDL HI+ F E RA+FYAA ++ GL+ L Sbjct: 74 HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT---DVFSEPRAVFYAACVVLGLQYL 130 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQR 361 H VYRDLK +N+LLD G ++I+D GL + + GD GT ++APEVL Sbjct: 131 HEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS 190 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 Y + D+WGLG LIYEM+ G+SPF G E EEV ++ E Y S EA SI + Sbjct: 191 YTRAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRFLSTEAISIMR 246 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRA 471 LL ++ ++RLG E+ A +VK+HPFFR +++ L + PPF+P R Sbjct: 247 RLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRG 296 >3HDN-A nrPDB Length = 373 Score = 185 bits (470), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 111/285 (38%), Positives = 159/285 (55%), Gaps = 9/285 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK-VNSQ 244 F +V+GKG FG+V + +A YA K L+KK I K+K E ++E+ +L K V Sbjct: 40 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP 99 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 F+V L ++++T D L VL +NGG+L +H+ F E RA FYAAEI L LH Sbjct: 100 FLVGLHFSFQTADKLYFVLDYINGGELFYHL--QRERCFLEPRARFYAAEIASALGYLHS 157 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 N VYRDLKPENILLD GHI ++D GL + I GT Y+APEVL+ Q Y Sbjct: 158 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 217 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 + D+W LG ++YEM+ G PF R + + + L+ + + A+ + + L Sbjct: 218 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP----NITNSARHLLEGL 273 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPD 468 L KD +RLG +++ E+K H FF +N+ L + PPF P+ Sbjct: 274 LQKDRTKRLGAKDD-FMEIKSHVFFSLINWDDLINKKITPPFNPN 317 >5D9K-A nrPDB Length = 330 Score = 184 bits (468), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 108/289 (37%), Positives = 163/289 (56%), Gaps = 13/289 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATG----KMYACKRLEKKRIKKRKGESMALNEKQILE 239 + F +VLG+G FG+V + + +G ++YA K L+K +K R + E+ IL Sbjct: 30 SQFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRVRTKM-ERDILV 87 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +VN F+V L YA++T+ L L+L + GGDL + F EE FY AE+ L Sbjct: 88 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALAL 145 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358 + LH +YRDLKPENILLD+ GHI+++D GL+ + I GTV YMAPEV+N Sbjct: 146 DHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN 205 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + + S D+W G L++EM+ G PF+G+ R+E +L+ + S EA+S Sbjct: 206 RRGHTQSADWWSFGVLMFEMLTGTLPFQGK----DRKETMTMILKAKLGMPQFLSPEAQS 261 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 + +ML ++ RLG +G E+KRH FF +++ +L + PPF P Sbjct: 262 LLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP 310 >4FR4-A nrPDB Length = 384 Score = 181 bits (458), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 97/310 (31%), Positives = 168/310 (54%), Gaps = 12/310 (3%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 E + V + F R +GKG FG+VC Q T KMYA K + K++ +R E Q Sbjct: 8 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQ 67 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ + F+VNL Y+++ ++ + +V+ ++ GGDL++H+ N F+EE + E++ Sbjct: 68 IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFKEETVKLFICELV 125 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 L+ L + ++RD+KP+NILLD++GH+ I+D +A +P I GT YMAPE+ Sbjct: 126 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 185 Query: 357 LNNQR---YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV-YSHKF 412 ++++ Y + D+W LG YE++ G+ P+ R +E V ET V Y + Sbjct: 186 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIV--HTFETTVVTYPSAW 243 Query: 413 SEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAV 472 S+E S+ K LL + QR ++V+ P+ ++N+ + L P F+P+ + Sbjct: 244 SQEMVSLLKKLLEPNPDQRFS----QLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRL 299 Query: 473 YCKDVLDIEQ 482 C ++E+ Sbjct: 300 NCDPTFELEE 309 >4WB7-A nrPDB Length = 405 Score = 179 bits (453), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 101/317 (31%), Positives = 170/317 (53%), Gaps = 16/317 (5%) Query: 155 GEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYAC 214 GE E+L D +W+ + + F + + LG G FG V + + TG YA Sbjct: 67 GEEVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAM 126 Query: 215 KRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH 274 K L+K+++ K K LNEK+IL+ VN F+V L ++++ L +V+ + GG++ H Sbjct: 127 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSH 186 Query: 275 IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV 334 + +G F E A FYAA+I+ E LH + +YRDLKPEN+L+D G+I+++D G A Sbjct: 187 LRRIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 244 Query: 335 KIPEGDLIRGRV----GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390 + ++GR GT Y+APE++ ++ Y + D+W LG LIYEM G PF + Sbjct: 245 R------VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQP 298 Query: 391 KVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 ++ +++ + + FS + K + + LL D +R G + G ++K H +F Sbjct: 299 I----QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 354 Query: 451 MNFKRLEAGMLDPPFVP 467 ++ + ++ PF+P Sbjct: 355 TDWIAIYQRKVEAPFIP 371 >1FOT-A nrPDB Length = 318 Score = 178 bits (451), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 98/282 (34%), Positives = 155/282 (54%), Gaps = 8/282 (2%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F+ R LG G FG V + R G+ YA K L+K+ + + K +E+ +L V F Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++ + ++ + +++ + GG+L F + F A FYAAE+ LE LH + Sbjct: 68 IIRMWGTFQDAQQIFMIMDYIEGGEL-FSLLRKSQ-RFPNPVAKFYAAEVCLALEYLHSK 125 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLS 365 + +YRDLKPENILLD GHI+I+D G A +P D+ GT Y+APEV++ + Y S Sbjct: 126 DIIYRDLKPENILLDKNGHIKITDFGFAKYVP--DVTYTLCGTPDYIAPEVVSTKPYNKS 183 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLT 425 D+W G LIYEM+ G +PF E ++L E + F+E+ K + L+T Sbjct: 184 IDWWSFGILIYEMLAGYTPFYDSNTMKTYE----KILNAELRFPPFFNEDVKDLLSRLIT 239 Query: 426 KDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 +D QRLG + G +VK HP+F+ + +++L + ++ P+ P Sbjct: 240 RDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEP 281 >5X3F-B nrPDB Length = 393 Score = 177 bits (448), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 96/304 (31%), Positives = 165/304 (54%), Gaps = 16/304 (5%) Query: 168 DRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG 227 D +W+ + + F + + LG G FG V + + +G YA K L+K+++ K K Sbjct: 68 DFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQ 127 Query: 228 ESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEER 287 LNEK+IL+ VN F+V L ++++ L +V+ + GG++ H+ +G F E Sbjct: 128 IEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGR--FSEPH 185 Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV- 346 A FYAA+I+ E LH + +YRDLKPEN+L+D G+I+++D G A + ++GR Sbjct: 186 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR------VKGRTW 239 Query: 347 ---GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 GT Y+APE++ ++ Y + D+W LG LIYEM G PF + ++ +++ Sbjct: 240 TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI----QIYEKIVS 295 Query: 404 TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDP 463 + + FS + K + + LL D +R G + G ++K H +F ++ + ++ Sbjct: 296 GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEA 355 Query: 464 PFVP 467 PF+P Sbjct: 356 PFIP 359 >5N23-A nrPDB Length = 352 Score = 176 bits (447), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 100/312 (32%), Positives = 166/312 (53%), Gaps = 7/312 (2%) Query: 156 EPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK 215 E E+L D +W+ + + F + R LG G FG V + + TG YA K Sbjct: 14 ESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMK 73 Query: 216 RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275 L+K+++ K K LNEK+I + VN F+V L ++++ L +VL GG++ H+ Sbjct: 74 ILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHL 133 Query: 276 YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 +G F E A FYAA+I+ E LH + +YRDLKPEN+L+D G+I+++D G A + Sbjct: 134 RRIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKR 191 Query: 336 IPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE 395 + +G GT Y+APE++ ++ Y + D+W LG LIYEM G PF + Sbjct: 192 V-KGRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI---- 246 Query: 396 EVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR 455 ++ +++ + + FS + K + + LL D +R G + G ++K H +F ++ Sbjct: 247 QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIA 306 Query: 456 LEAGMLDPPFVP 467 + ++ PF+P Sbjct: 307 IYQRKVEAPFIP 318 >3ORZ-A nrPDB Length = 316 Score = 171 bits (434), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 98/275 (35%), Positives = 156/275 (56%), Gaps = 10/275 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F+ ++LG+G F V + AT + YA K LEK+ I K E+ ++ +++ F Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 98 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 V L + ++ + L L+ G+L +I +G+ F+E FY AEI+ LE LH + Sbjct: 99 FVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGS--FDETCTRFYTAEIVSALEYLHGK 156 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLA-VKIPEGDLIRGR--VGTVGYMAPEVLNNQRY 362 ++RDLKPENILL++ HI+I+D G A V PE R VGT Y++PE+L + Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 216 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKM 422 S D W LGC+IY+++ G PFR E + + +++++ E + KF +A+ + + Sbjct: 217 CKSSDLWALGCIIYQLVAGLPPFRAGNEYL----IFQKIIKLEYDFPEKFFPKARDLVEK 272 Query: 423 LLTKDAKQRLGCQE-EGAAEVKRHPFFRNMNFKRL 456 LL DA +RLGC+E EG +K HPFF ++ ++ L Sbjct: 273 LLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 307 >6BDL-A nrPDB Length = 347 Score = 162 bits (409), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 92/283 (32%), Positives = 154/283 (54%), Gaps = 5/283 (1%) Query: 186 FRQYRVLGKGGFGEVCACQVRAT-GKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F LG GGFG V Q+++ K +A K L+K+ I + + +EKQI++ +S Sbjct: 36 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 95 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 F+V L ++ L +++ GG+L + + G+ FE+ FY A ++ LH Sbjct: 96 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGS--FEDSTTRFYTACVVEAFAYLHS 153 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 + +YRDLKPEN++LD G+ ++ D G A KI G GT Y+APE++ N+ + + Sbjct: 154 KGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI 213 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLL 424 S DYW LG L+YE++ G PF G + +K + R ++ E + K ++ A ++ K L Sbjct: 214 SADYWSLGILMYELLTGSPPFSG-PDPMKTYNIILRGIDMIE-FPKKIAKNAANLIKKLC 271 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 + +RLG + G ++++H +F N++ L G L PP +P Sbjct: 272 RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIP 314 >6ED6-A nrPDB Length = 415 Score = 161 bits (407), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 105/319 (32%), Positives = 162/319 (50%), Gaps = 35/319 (10%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 +V+G+G FGEV + +A+ K+YA K L K + KR + E+ I+ NS +VV L Sbjct: 94 KVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL 153 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 YA++ L +V+ M GGDL + M N E+ A FY AE++ L+ +H ++ Sbjct: 154 FYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIH 210 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR--GRVGTVGYMAPEVLNNQR----YG 363 RD+KP+N+LLD +GH++++D G +K+ E ++ VGT Y++PEVL +Q YG Sbjct: 211 RDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYG 270 Query: 364 LSPDYWGLGCLIYEMIEGQSPFR-----GRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 D+W +G +YEM+ G +PF G K+ + E E+ H AK+ Sbjct: 271 RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKH-----AKN 325 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVL 478 + LT D + RLG G E+++HPFF+N + P VP Sbjct: 326 LICAFLT-DREVRLG--RNGVEEIRQHPFFKNDQWHWDNIRETAAPVVP----------- 371 Query: 479 DIEQFSTVKGVNLDHTDDD 497 E S + N D +DD Sbjct: 372 --ELSSDIDSSNFDDIEDD 388 >6E9W-A nrPDB Length = 443 Score = 160 bits (406), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 102/295 (34%), Positives = 156/295 (52%), Gaps = 32/295 (10%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 +V+G+G FGEV + ++T K+YA K L K + KR + E+ I+ NS +VV L Sbjct: 108 KVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL 167 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 YA++ L +V+ M GGDL + M N E+ A FY AE++ L+ +H ++ Sbjct: 168 FYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIH 224 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR--GRVGTVGYMAPEVLNNQ----RYG 363 RD+KP+N+LLD GH++++D G +K+ + ++R VGT Y++PEVL +Q YG Sbjct: 225 RDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG 284 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK----------FS 413 D+W +G +YEM+ G +PF D V ++ +HK S Sbjct: 285 RECDWWSVGVFLYEMLVGDTPFYA----------DSLVGTYSKIMNHKNSLTFPDDNDIS 334 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPD 468 +EAK++ LT D + RLG G E+KRH FF+N + P VPD Sbjct: 335 KEAKNLICAFLT-DREVRLG--RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPD 386 >5DYK-A nrPDB Length = 853 Score = 158 bits (399), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 99/299 (33%), Positives = 157/299 (52%), Gaps = 17/299 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R++G+G FG V + T YA K + K+ I ++ E++I + + F++ L Sbjct: 545 RIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRL 604 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 ++ + ++ GG+L I +G + +A FY I+ +E LH N VY Sbjct: 605 VRTFKDSKYFYFLTELVTGGELYDAIRKLG--LLSKSQAQFYLGSIILAIEYLHERNIVY 662 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR----VGTVGYMAPEVLNNQRYGLS 365 RDLKPENILLD G++++ D G A K ++GR VGT YMAPEV+ + YG + Sbjct: 663 RDLKPENILLDKQGYVKLIDFGCAKK------VQGRAYTLVGTPHYMAPEVILGKGYGCT 716 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE-EAKSICKMLL 424 D W LG +YE I G PF +E + E+ R +L + + ++ ++ ++ K LL Sbjct: 717 VDIWALGICLYEFICGPLPFGNDEE--DQLEIFRDILTGQLTFPDYVTDTDSINLMKRLL 774 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF 483 + + R+GC G ++K HPFF N N+ +L +LDPP V Y +D+ DI+Q Sbjct: 775 CRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSET-YAEDI-DIKQI 831 >3TKU-A nrPDB Length = 433 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 97/320 (30%), Positives = 173/320 (54%), Gaps = 27/320 (8%) Query: 166 FFDRFLQW-----KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK 220 + FL+W + ++ + + F +V+G+G FGEV +++ T ++YA K L K Sbjct: 67 YVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKW 126 Query: 221 RIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN 280 + KR + E+ +L + Q++ L YA++ ++ L LV+ GGDL + + Sbjct: 127 EMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDL-LTLLSKFE 185 Query: 281 PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD 340 E+ A FY E++ ++ +H+ + V+RD+KP+N+LLD GHIR++D G +K+ + Sbjct: 186 DKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDG 245 Query: 341 LIRGR--VGTVGYMAPEVLNNQ-----RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVK 393 ++ VGT Y++PE+L +YG D+W LG +YEM+ G++PF Sbjct: 246 TVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE----S 301 Query: 394 REEVDRRVLETEEVY---SH--KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 E +++ EE + SH SEEAK + + L+ ++RLG + G + K+H FF Sbjct: 302 LVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICS-RERRLG--QNGIEDFKKHAFF 358 Query: 449 RNMNFKRLEAGMLDPPFVPD 468 +N++ + L+ P++PD Sbjct: 359 EGLNWENIRN--LEAPYIPD 376 >5FET-A nrPDB Length = 847 Score = 155 bits (391), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 100/306 (32%), Positives = 159/306 (51%), Gaps = 17/306 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R++G+G FG V + T YA K + K+ I ++ E++I + + F++ L Sbjct: 539 RIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRL 598 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 ++ + + ++ GG+L I +G + +A FY I+ +E LH N VY Sbjct: 599 VRTFKDSNCFYFLTELVTGGELYDAIRKLG--LLSKPQAQFYLGSIILAIEYLHERNIVY 656 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR----VGTVGYMAPEVLNNQRYGLS 365 RDLKPENILLD G++++ D G A K I+GR VGT YMAPEV+ + YG + Sbjct: 657 RDLKPENILLDKQGYVKLIDFGCAKK------IQGRAYTLVGTPHYMAPEVILGKGYGCT 710 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS-EEAKSICKMLL 424 D W LG +YE I G PF +E + E+ R +L + + S +++ ++ K LL Sbjct: 711 VDIWALGVCLYEFICGPLPFGNDQE--DQLEIFRDILTGQLTFPDYVSDQDSINLMKRLL 768 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFS 484 + + R+GC G ++K H FF N N+ +L +L+PP V Y +D+ DI+Q Sbjct: 769 CRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGET-YAEDI-DIKQIE 826 Query: 485 TVKGVN 490 +N Sbjct: 827 EEDALN 832 >5LOH-A nrPDB Length = 341 Score = 154 bits (388), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 94/300 (31%), Positives = 162/300 (54%), Gaps = 23/300 (7%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 +P + F + + +G FG+V Q GK+YA K ++K + + E+ L Sbjct: 31 KPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDAL 88 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLK--FHIYNMGNPGFEEERALFYAAEIL 296 S F+V+L Y+ ++ + + LV+ + GGD+K HIY F+EE A+ Y +E+ Sbjct: 89 ALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGY----FDEEMAVKYISEVA 144 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV-----KIPEGDLIRGRV--GTV 349 L+ LHR ++RDLKP+N+L+ + GHI+++D GL+ I D++ R GT Sbjct: 145 LALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTP 204 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS 409 Y+APE+L + +G + D+W LG ++E + G PF + + + +R + E Sbjct: 205 DYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPE-GE 263 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDP 469 K S+ A+S ++LLT D +R G + E+KRHP F +++++ L+ + PF+P P Sbjct: 264 EKLSDNAQSAVEILLTIDDTKRAGMK-----ELKRHPLFSDVDWENLQHQTM--PFIPQP 316 >4AW2-A nrPDB Length = 437 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 91/298 (30%), Positives = 159/298 (53%), Gaps = 22/298 (7%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + F +V+G+G FGEV +++ K++A K L K + KR + E+ +L + Sbjct: 73 REDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 S+++ L YA++ + L LV+ GGDL + + EE A FY AE++ ++ + Sbjct: 133 SKWITTLHYAFQDDNNLYLVMDYYVGGDL-LTLLSKFEDRLPEEMARFYLAEMVIAIDSV 191 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR--VGTVGYMAPEVLNNQ 360 H+ + V+RD+KP+NIL+D GHIR++D G +K+ E ++ VGT Y++PE+L Sbjct: 192 HQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAM 251 Query: 361 -----RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH----- 410 RYG D+W LG +YEM+ G++PF E +++ +E + Sbjct: 252 EGGKGRYGPECDWWSLGVCMYEMLYGETPFYAE----SLVETYGKIMNHKERFQFPTQVT 307 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPD 468 SE AK + + L+ + RLG + G + K+HPFF +++ + + P++P+ Sbjct: 308 DVSENAKDLIRRLICS-REHRLG--QNGIEDFKKHPFFSGIDWDNIRN--CEAPYIPE 360 >2VD5-A nrPDB Length = 412 Score = 148 bits (374), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 101/318 (31%), Positives = 159/318 (50%), Gaps = 29/318 (9%) Query: 170 FLQWK-----WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK 224 FLQW L+ + ++ F +V+G+G F EV +++ TG++YA K + K + K Sbjct: 42 FLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLK 101 Query: 225 RKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE 284 R S E+ +L + +++ L +A++ ++ L LV+ GGDL + G Sbjct: 102 RGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGER-IP 160 Query: 285 EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG 344 E A FY AEI+ ++ +HR V+RD+KP+NILLD GHIR++D G +K+ +R Sbjct: 161 AEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRS 220 Query: 345 --RVGTVGYMAPEVLNNQRYGLSP-------DYWGLGCLIYEMIEGQSPFRGRKEKVKRE 395 VGT Y++PE+L G D+W LG YEM GQ+PF Sbjct: 221 LVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTA---- 276 Query: 396 EVDRRVLETEE-----VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 E +++ +E + EEA+ + LL + RLG GA + + HPFF Sbjct: 277 ETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLG--RGGAGDFRTHPFFFG 333 Query: 451 MNFKRLEAGMLDPPFVPD 468 +++ L + PPF PD Sbjct: 334 LDWDGLRDSV--PPFTPD 349 >4C0T-A nrPDB Length = 974 Score = 142 bits (358), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 94/313 (30%), Positives = 160/313 (51%), Gaps = 28/313 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F+ + LG+G + V + TGK YA K L+K+ I K K EK L +++++ Sbjct: 268 FKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRL 327 Query: 246 -VVNLAYAYETKDALCLVLTIMNGGDLKFHI--YNMGNPGFEEERALFYAAEILCGLEDL 302 V++L + ++ KD+L VL + G+L I YN N EE + A+IL ++ + Sbjct: 328 GVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLN----EECTRHFGAQILDAIKYM 383 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKI----------PEGDLIRGRVGTVGYM 352 H ++RDLKPENILLDD I+I+D G A + P + VGT Y+ Sbjct: 384 HDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYV 443 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 +PE+L N+ G D W GC+IY+MI G+ PF+ E + + ++ + + +S F Sbjct: 444 SPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQ----KITKLQFAFSAGF 499 Query: 413 SEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGML-DPPFVPDPRA 471 + + K +L +R E+++H FF++++FK ++ L DPP + P Sbjct: 500 PTIIRDLIKKILVLQPSRRATI-----PEIQKHYFFQSVDFKDFDSIWLSDPPEI-GPYK 553 Query: 472 VYCKDVLDIEQFS 484 + K ++ + + + Sbjct: 554 MTAKSMMKVPELN 566 >2JC6-A nrPDB Length = 334 Score = 140 bits (354), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 91/277 (32%), Positives = 142/277 (51%), Gaps = 12/277 (4%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNE 234 W ++ K F LG G F EV + +ATGK++A K + KK +K + ES NE Sbjct: 13 WKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK--ESSIENE 70 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 +L K+ + +V L YE+ + L LV+ +++GG+L I G + E+ A + Sbjct: 71 IAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIRQ 128 Query: 295 ILCGLEDLHRENTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGY 351 +L + LHR V+RDLKPEN+L D+ I ISD GL+ +GD++ GT GY Sbjct: 129 VLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGY 188 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 +APEVL + Y + D W +G + Y ++ G PF + E++ + E + Y Sbjct: 189 VAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 248 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 S+ AK + L+ KD +R C++ RHP+ Sbjct: 249 ISDSAKDFIRNLMEKDPNKRYTCEQAA-----RHPWI 280 >1ZWS-A nrPDB Length = 288 Score = 130 bits (327), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 88/265 (33%), Positives = 139/265 (52%), Gaps = 16/265 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIK-KRKGESMALNEKQ--ILEKVNSQFVVN 248 LG G F V C+ ++TG YA K ++K++ + R+G S E++ IL +V V+ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV 308 L YE + + L+L +++GG+L + EE A + +IL G+ LH + Sbjct: 80 LHDVYENRTDVVLILELVSGGEL--FDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIA 137 Query: 309 YRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 + DLKPENI+L D HI++ D GLA +I +G + GT ++APE++N + GL Sbjct: 138 HFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGL 197 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE-TEEVYSHKFSEEAKSICKML 423 D W +G + Y ++ G SPF G ++ + + EE +SH SE AK + L Sbjct: 198 EADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHT-SELAKDFIRKL 256 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFF 448 L K+ ++RL Q E RHP+ Sbjct: 257 LVKETRKRLTIQ-----EALRHPWI 276 >2A27-A nrPDB Length = 321 Score = 130 bits (326), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 85/264 (32%), Positives = 138/264 (52%), Gaps = 14/264 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIK-KRKGESMALNEKQ--ILEKVNSQFVVN 248 LG G F V C+ ++TG YA K ++K++ + R+G S E++ IL +V V+ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV 308 L YE + + L+L +++GG+L + EE A + +IL G+ LH + Sbjct: 80 LHDVYENRTDVVLILELVSGGEL--FDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIA 137 Query: 309 YRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 + DLKPENI+L D HI++ D GLA +I +G + GT ++APE++N + GL Sbjct: 138 HFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGL 197 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLL 424 D W +G + Y ++ G SPF G ++ + + +E + + SE AK + LL Sbjct: 198 EADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLL 257 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFF 448 K+ ++RL Q E RHP+ Sbjct: 258 VKETRKRLTIQ-----EALRHPWI 276 >3GUB-A nrPDB Length = 295 Score = 128 bits (322), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 88/265 (33%), Positives = 134/265 (50%), Gaps = 14/265 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKK-RKGESMALNEKQ--ILEKVNSQFVVN 248 LG G F V C+ ++TG YA K ++K+R K R+G S E++ IL+++ V+ Sbjct: 19 LGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVIT 78 Query: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV 308 L YE K + L+ ++ GG+L + EE A + +IL G+ LH Sbjct: 79 LHEVYENKTDVILIGELVAGGEL--FDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIA 136 Query: 309 YRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 + DLKPENI+L D I+I D GLA KI G+ + GT ++APE++N + GL Sbjct: 137 HFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGL 196 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLL 424 D W +G + Y ++ G SPF G ++ V E E+ Y S AK + LL Sbjct: 197 EADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLL 256 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFFR 449 KD K+R+ Q+ +HP+ + Sbjct: 257 VKDPKKRMTIQDS-----LQHPWIK 276 >6BXI-A nrPDB Length = 333 Score = 128 bits (322), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 85/311 (27%), Positives = 146/311 (46%), Gaps = 49/311 (15%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F +V+G+G FGEV Q + TG +YA K L K + +++ E+ IL + +S + Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW 67 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 VV + Y+++ K L L++ + GGD+ + M EE FY AE + ++ +H+ Sbjct: 68 VVKMFYSFQDKLNLYLIMEFLPGGDMMTLL--MKKDTLTEEETQFYIAETVLAIDSIHQL 125 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-------------------------- 339 ++RD+KP+N+LLD GH+++SD GL + + Sbjct: 126 GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 185 Query: 340 ----------DLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRK 389 L VGT Y+APEV Y D+W LG ++YEM+ G PF Sbjct: 186 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 245 Query: 390 EKVKREEVDRRVLETEEVYSH----KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRH 445 +E ++V+ +E + SE+AK + + + + R+G G E+K + Sbjct: 246 P----QETYKKVMNWKETLTFPPEVPISEKAKDLI-LRFCCEWEHRIGAP--GVEEIKSN 298 Query: 446 PFFRNMNFKRL 456 FF ++++ + Sbjct: 299 SFFEGVDWEHI 309 >4LQP-A nrPDB Length = 508 Score = 128 bits (321), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 97/348 (27%), Positives = 156/348 (44%), Gaps = 76/348 (21%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F +V+GKG FGEV Q + TGK+YA K L K + K+ + E+ +L +S + Sbjct: 104 FHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPW 163 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 VV+L Y+++ L L++ + GGDL + F E+ FY AE + +E +H+ Sbjct: 164 VVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRW--QLFTEDVTRFYMAECILAIETIHKL 221 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-------LIRGRVGTVGYMAPEVLN 358 ++R +KP+NIL+D GHI++SD GL+ + L++ T G P N Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYN 281 Query: 359 -------NQRYGL-------------------------------SPDY------------ 368 N+R + +PDY Sbjct: 282 ANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYG 341 Query: 369 -----WGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH----KFSEEAKSI 419 W LG ++YE + G PF +E R+++ E+ S EA+ + Sbjct: 342 QECDWWSLGAIMYECLIGWPPFCSETP----QETYRKIMNFEQTLQFPDDIHISYEAEDL 397 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 + LLT A QRLG + GA E+K HPFFR +++ + ++ P++P Sbjct: 398 IRRLLTH-ADQRLG-RHGGADEIKSHPFFRGVDWNTIR--QVEAPYIP 441 >2YAB-A nrPDB Length = 361 Score = 127 bits (320), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 87/280 (31%), Positives = 143/280 (51%), Gaps = 23/280 (8%) Query: 185 TFRQYRV---------LGKGGFGEVCACQVRATGKMYACKRLEKKRIK-KRKGESMALNE 234 TF+Q +V LG G F V C+ ++TG YA K ++K++ + R+G E Sbjct: 4 TFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIE 63 Query: 235 KQ--ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 ++ IL +V ++ L YE + + L+L +++GG+L + EE A + Sbjct: 64 REVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGEL--FDFLAQKESLSEEEATSFI 121 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGT 348 +IL G+ LH + + DLKPENI+L D HI++ D GLA +I +G + GT Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY 408 ++APE++N + GL D W +G + Y ++ G SPF G ++ + + +E + Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF 241 Query: 409 SHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + SE AK + LL K+ ++RL Q E RHP+ Sbjct: 242 FSQTSELAKDFIRKLLVKETRKRLTIQ-----EALRHPWI 276 >3MA6-A nrPDB Length = 298 Score = 126 bits (316), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 80/260 (30%), Positives = 135/260 (51%), Gaps = 6/260 (2%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 + + ++ RVLGKG FGEV C+ + TG+ A K + K+++K++ + L E Q+L+ Sbjct: 28 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLK 87 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +++ ++ L +E K LV + GG+L I + F E A ++L G+ Sbjct: 88 QLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEI--ISRKRFSEVDAARIIRQVLSGI 145 Query: 300 EDLHRENTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 +H+ V+RDLKPEN+LL+ +IRI D GL+ ++ ++GT Y+APEV Sbjct: 146 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 205 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 L+ Y D W G ++Y ++ G PF G E ++V++ E K SE A Sbjct: 206 LHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESA 264 Query: 417 KSICKMLLTKDAKQRLGCQE 436 K + + +LT R+ ++ Sbjct: 265 KDLIRKMLTYVPSMRISARD 284 >2J90-A nrPDB Length = 304 Score = 126 bits (316), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 81/265 (30%), Positives = 136/265 (51%), Gaps = 9/265 (3%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK-RKGESMALNEKQ- 236 Q + ++ + LG G F V C+ + TGK YA K ++K+R+ R+G S E++ Sbjct: 21 QSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 80 Query: 237 -ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 IL ++ ++ L +E K + L+L +++GG+L + E+ A + +I Sbjct: 81 NILREIRHPNIITLHDIFENKTDVVLILELVSGGEL--FDFLAEKESLTEDEATQFLKQI 138 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVGY 351 L G+ LH + + DLKPENI+L D I++ D G+A KI G+ + GT + Sbjct: 139 LDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEF 198 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 +APE++N + GL D W +G + Y ++ G SPF G ++ + + +E Y Sbjct: 199 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSN 258 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQE 436 SE AK + LL KD K+R+ + Sbjct: 259 TSELAKDFIRRLLVKDPKRRMTIAQ 283 >2JAM-A nrPDB Length = 304 Score = 125 bits (313), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 83/257 (32%), Positives = 131/257 (50%), Gaps = 9/257 (3%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + TF VLG G F EV + R TGK++A K ++K + +S NE +L+K+ Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFR---DSSLENEIAVLKKIK 64 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 + +V L YE+ LV+ +++GG+L I G + E+ A ++L ++ L Sbjct: 65 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYL 122 Query: 303 HRENTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 H V+RDLKPEN+L ++ I I+D GL+ K+ + ++ GT GY+APEVL Sbjct: 123 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLS-KMEQNGIMSTACGTPGYVAPEVLAQ 181 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 + Y + D W +G + Y ++ G PF E E++ E E + SE AK Sbjct: 182 KPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDF 241 Query: 420 CKMLLTKDAKQRLGCQE 436 LL KD +R C++ Sbjct: 242 ICHLLEKDPNERYTCEK 258 >5JN2-A nrPDB Length = 525 Score = 125 bits (313), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 80/260 (30%), Positives = 135/260 (51%), Gaps = 6/260 (2%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 + + ++ RVLGKG FGEV C+ + TG+ A K + K+++K++ + L E Q+L+ Sbjct: 63 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLK 122 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +++ ++ L +E K LV + GG+L I + F E A ++L G+ Sbjct: 123 QLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEI--ISRKRFSEVDAARIIRQVLSGI 180 Query: 300 EDLHRENTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 +H+ V+RDLKPEN+LL+ +IRI D GL+ ++ ++GT Y+APEV Sbjct: 181 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 240 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 L+ Y D W G ++Y ++ G PF G E ++V++ E K SE A Sbjct: 241 LHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESA 299 Query: 417 KSICKMLLTKDAKQRLGCQE 436 K + + +LT R+ ++ Sbjct: 300 KDLIRKMLTYVPSMRISARD 319 >3TAC-A nrPDB Length = 361 Score = 121 bits (304), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 81/275 (29%), Positives = 131/275 (47%), Gaps = 14/275 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM--ALNEKQILEK 240 ++ + V+GKG F V C R TG+ +A K ++ + G S E I Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF--EEERALFYAAEILCG 298 + +V L Y + L +V M+G DL F I + GF E A Y +IL Sbjct: 85 LKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEA 144 Query: 299 LEDLHRENTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRG-RVGTVGYMAP 354 L H N ++RD+KP +LL ++ +++ G+A+++ E L+ G RVGT +MAP Sbjct: 145 LRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAP 204 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE 414 EV+ + YG D WG G +++ ++ G PF G KE++ + + +SH SE Sbjct: 205 EVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSH-ISE 263 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 AK + + +L D +R+ E HP+ + Sbjct: 264 SAKDLVRRMLMLDPAERITVY-----EALNHPWLK 293 >3DXN-A nrPDB Length = 287 Score = 121 bits (303), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 137/268 (51%), Gaps = 11/268 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + +++ + LG G +GEV C+ + TG A K ++K + L+E +L++++ Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L +E K LV+ + GG+L I + F E A ++L G LH Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI--ILRQKFSEVDAAVIMKQVLSGTTYLH 138 Query: 304 RENTVYRDLKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 + N V+RDLKPEN+LL+ I+I D GL+ G ++ R+GT Y+APEVL + Sbjct: 139 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL-RK 197 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 +Y D W G ++Y ++ G PF G+ ++ + V++ + + S+EAK + Sbjct: 198 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 257 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 K++LT + +R+ A E HP+ Sbjct: 258 KLMLTYEPSKRI-----SAEEALNHPWI 280 >5XZW-A nrPDB Length = 471 Score = 121 bits (303), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 79/273 (28%), Positives = 131/273 (47%), Gaps = 24/273 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 V+G+G F V R TGK +A K + K+++ E ++L+K+N +V L Sbjct: 203 VVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNM--DGVTRELEVLQKLNHPRIVRLK 260 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 YE ++ +V+ ++GGDL + G G + R + + +IL ++ +H +R Sbjct: 261 GFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREI--SRQILTAIKYIHSMGISHR 318 Query: 311 DLKPENILL--DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD- 367 DLKP+NIL+ DD ++I+D GLA G ++ GT+ Y+APEV+ + +SPD Sbjct: 319 DLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDE 378 Query: 368 ------------YWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 W +GCL+Y ++ G PF G + +++ R + + SEE Sbjct: 379 YEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEE 438 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 A+ LL D R AA+ HP+ Sbjct: 439 ARDFIDSLLQVDPNNR-----STAAKALNHPWI 466 >4FG9-A nrPDB Length = 320 Score = 121 bits (303), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 84/278 (30%), Positives = 142/278 (51%), Gaps = 13/278 (4%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN 233 +W + + + ++ + VLG G F EV + + T K+ A K + K+ ++ ++G SM N Sbjct: 9 RWKQAEDI-RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEG-SME-N 65 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 E +L K+ +V L YE+ L L++ +++GG+L I G + E A Sbjct: 66 EIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGF--YTERDASRLIF 123 Query: 294 EILCGLEDLHRENTVYRDLKPENIL---LDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG 350 ++L ++ LH V+RDLKPEN+L LD+ I ISD GL+ G ++ GT G Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPG 183 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 Y+APEVL + Y + D W +G + Y ++ G PF + E++ + E + Y Sbjct: 184 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWD 243 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 S+ AK + L+ KD ++R C+ + +HP+ Sbjct: 244 DISDSAKDFIRHLMEKDPEKRFTCE-----QALQHPWI 276 >3HZT-A nrPDB Length = 467 Score = 121 bits (303), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 137/268 (51%), Gaps = 11/268 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + +++ + LG G +GEV C+ + TG A K ++K + L+E +L++++ Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L +E K LV+ + GG+L I + F E A ++L G LH Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI--ILRQKFSEVDAAVIMKQVLSGTTYLH 121 Query: 304 RENTVYRDLKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 + N V+RDLKPEN+LL+ I+I D GL+ G ++ R+GT Y+APEVL + Sbjct: 122 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL-RK 180 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 +Y D W G ++Y ++ G PF G+ ++ + V++ + + S+EAK + Sbjct: 181 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 240 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 K++LT + +R+ A E HP+ Sbjct: 241 KLMLTYEPSKRI-----SAEEALNHPWI 263 >1KOB-A nrPDB Length = 387 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 85/299 (28%), Positives = 143/299 (47%), Gaps = 31/299 (10%) Query: 167 FDRFLQ--WKWLERQPV---TKNTFRQYRVL---GKGGFGEVCACQVRATGKMYACK--- 215 +D+F + WK QPV + + Y +L G G FG V C +ATG+++ K Sbjct: 26 YDKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFIN 85 Query: 216 ---RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLK 272 L+K +K NE I+ +++ ++NL A+E K + L+L ++GG+L Sbjct: 86 TPYPLDKYTVK---------NEISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGEL- 135 Query: 273 FHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD--YGHIRISDL 330 F + E + Y + GL+ +H + V+ D+KPENI+ + ++I D Sbjct: 136 FDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDF 195 Query: 331 GLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390 GLA K+ ++++ T + APE+++ + G D W +G L Y ++ G SPF G + Sbjct: 196 GLATKLNPDEIVKVTTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDD 255 Query: 391 KVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 + V R E +E S EAK K LL K+ ++RL + HP+ + Sbjct: 256 LETLQNVKRCDWEFDEDAFSSVSPEAKDFIKNLLQKEPRKRLTVH-----DALEHPWLK 309 >4FIE-A nrPDB Length = 423 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 76/258 (29%), Positives = 130/258 (50%), Gaps = 13/258 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G G VC VR++GK+ A K+++ ++ ++R+ + NE I+ + VV + Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE---LLFNEVVIMRDYQHENVVEMYN 215 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 +Y D L +V+ + GG L + + EE+ +L L LH + ++RD Sbjct: 216 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSVLHAQGVIHRD 272 Query: 312 LKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG 370 +K ++ILL G +++SD G ++ E + VGT +MAPE+++ YG D W Sbjct: 273 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 332 Query: 371 LGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ 430 LG ++ EM++G+ P+ + +K ++ R L HK S K LL +D Q Sbjct: 333 LGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 391 Query: 431 RLGCQEEGAAEVKRHPFF 448 R AAE+ +HPF Sbjct: 392 R-----ATAAELLKHPFL 404 >4XBR-A nrPDB Length = 366 Score = 119 bits (297), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 76/258 (29%), Positives = 130/258 (50%), Gaps = 13/258 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G G VC VR++GK+ A K+++ ++ ++R+ + NE I+ + VV + Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE---LLFNEVVIMRDYQHENVVEMYN 158 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 +Y D L +V+ + GG L + + EE+ +L L LH + ++RD Sbjct: 159 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSVLHAQGVIHRD 215 Query: 312 LKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG 370 +K ++ILL G +++SD G ++ E + VGT +MAPE+++ YG D W Sbjct: 216 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 275 Query: 371 LGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ 430 LG ++ EM++G+ P+ + +K ++ R L HK S K LL +D Q Sbjct: 276 LGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 334 Query: 431 RLGCQEEGAAEVKRHPFF 448 R AAE+ +HPF Sbjct: 335 R-----ATAAELLKHPFL 347 >2Q0N-A nrPDB Length = 301 Score = 119 bits (297), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 76/258 (29%), Positives = 130/258 (50%), Gaps = 13/258 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G G VC VR++GK+ A K+++ ++ ++R+ + NE I+ + VV + Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE---LLFNEVVIMRDYQHENVVEMYN 93 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 +Y D L +V+ + GG L + + EE+ +L L LH + ++RD Sbjct: 94 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 312 LKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG 370 +K ++ILL G +++SD G ++ E + VGT +MAPE+++ YG D W Sbjct: 151 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 210 Query: 371 LGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ 430 LG ++ EM++G+ P+ + +K ++ R L HK S K LL +D Q Sbjct: 211 LGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 269 Query: 431 RLGCQEEGAAEVKRHPFF 448 R AAE+ +HPF Sbjct: 270 R-----ATAAELLKHPFL 282 >4JDH-A nrPDB Length = 346 Score = 118 bits (296), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 76/258 (29%), Positives = 130/258 (50%), Gaps = 13/258 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G G VC VR++GK+ A K+++ ++ ++R+ + NE I+ + VV + Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE---LLFNEVVIMRDYQHENVVEMYN 138 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 +Y D L +V+ + GG L + + EE+ +L L LH + ++RD Sbjct: 139 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSVLHAQGVIHRD 195 Query: 312 LKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG 370 +K ++ILL G +++SD G ++ E + VGT +MAPE+++ YG D W Sbjct: 196 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 255 Query: 371 LGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ 430 LG ++ EM++G+ P+ + +K ++ R L HK S K LL +D Q Sbjct: 256 LGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 314 Query: 431 RLGCQEEGAAEVKRHPFF 448 R AAE+ +HPF Sbjct: 315 R-----ATAAELLKHPFL 327 >4PDS-A nrPDB Length = 347 Score = 117 bits (294), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 77/274 (28%), Positives = 131/274 (47%), Gaps = 24/274 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 V+G+G F V R TGK ++ K + K+++ E ++L+K+N +V L Sbjct: 38 VVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNM--DGVTRELEVLQKLNHPRIVRLK 95 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 YE ++ +V+ ++GGDL + G G + R + + +IL ++ +H +R Sbjct: 96 GFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREI--SRQILTAIKYIHSMGISHR 153 Query: 311 DLKPENILL--DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD- 367 DLKP+NIL+ DD ++I+ GLA G ++ GT+ Y+APEV+ + +SPD Sbjct: 154 DLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDE 213 Query: 368 ------------YWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 W +GCL+Y ++ G PF G + +++ R + + SEE Sbjct: 214 YEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEE 273 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 A+ LL D R AA+ HP+ + Sbjct: 274 ARDFIDSLLQVDPNNR-----STAAKALNHPWIK 302 >4RGJ-A nrPDB Length = 520 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 77/257 (29%), Positives = 132/257 (51%), Gaps = 11/257 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++ ++LGKG FGEV + + TG YA K + KK +K++ + L E ++L+ ++ Sbjct: 62 YKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHIN 121 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++ L +E + LV + GG+L I + F E A +IL G+ +H+ Sbjct: 122 IMKLYEFFEDNNYYYLVSDVYTGGELFDEI--ISRKRFYEIDAARIIKQILSGITYMHKN 179 Query: 306 NTVYRDLKPENILLDDYGH----IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 N V+RDLKPENILL+ I+I D GL+ ++ ++GT Y+AP+VL+ Sbjct: 180 NVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT- 238 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEK--VKREEVDRRVLETEEVYSHKFSEEAKSI 419 Y D W G ++Y ++ G PF G E +K+ E + + + K S++AK + Sbjct: 239 YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQF--KKISDKAKDL 296 Query: 420 CKMLLTKDAKQRLGCQE 436 K +L + R+ ++ Sbjct: 297 IKKMLMYTSAVRISARD 313 >3DFA-A nrPDB Length = 286 Score = 116 bits (291), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 82/264 (31%), Positives = 131/264 (49%), Gaps = 16/264 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 +LGKG FGEV C+ R T + YA K + K K K S L E ++L+K++ ++ L Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVKVINKAS-AKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 E + +V + GG+L I + F E A ++ G+ +H+ N V+R Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEI--IKRKRFSEHDAARIIKQVFSGITYMHKHNIVHR 145 Query: 311 DLKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD 367 DLKPENILL+ I+I D GL+ + ++ R+GT Y+APEVL Y D Sbjct: 146 DLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT-YDEKCD 204 Query: 368 YWGLGCLIYEMIEGQSPFRGRKEK--VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLT 425 W G ++Y ++ G PF G+ E +KR E + + + + S++AK + + +LT Sbjct: 205 VWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRT--ISDDAKDLIRKMLT 262 Query: 426 KDAKQRLGCQEEGAAEVKRHPFFR 449 R+ A + HP+ + Sbjct: 263 FHPSLRI-----TATQCLEHPWIQ 281 >4YZB-A nrPDB Length = 491 Score = 116 bits (290), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 79/254 (31%), Positives = 135/254 (53%), Gaps = 6/254 (2%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++ RVLGKG FGEV C+ + TG+ YA K + K+++K++ + + L E ++L+K++ Sbjct: 32 YKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPN 91 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++ L +E K LV + GG+L I + F E A ++L G+ +H+ Sbjct: 92 IMKLYEFFEDKGYFYLVTEVYTGGELFDEI--ISRKRFSEVDAARIIRQVLSGITYMHKN 149 Query: 306 NTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 V+RDLKPEN+LL++ +IRI D GL+ ++ ++GT Y+APEVL+ Y Sbjct: 150 KIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGT-Y 208 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKM 422 D W G ++Y ++ G PF G E ++V++ + K SE AK + + Sbjct: 209 DEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRK 268 Query: 423 LLTKDAKQRLGCQE 436 +L R+ ++ Sbjct: 269 MLAYVPTMRISARD 282 >3NCG-A nrPDB Length = 486 Score = 116 bits (290), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 82/264 (31%), Positives = 131/264 (49%), Gaps = 16/264 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 +LGKG FGEV C+ R T + YA K + K K K S L E ++L+K++ ++ L Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVKVINKAS-AKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 E + +V + GG+L I + F E A ++ G+ +H+ N V+R Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEI--IKRKRFSEHDAARIIKQVFSGITYMHKHNIVHR 145 Query: 311 DLKPENILLDDYG---HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD 367 DLKPENILL+ I+I D GL+ + ++ R+GT Y+APEVL Y D Sbjct: 146 DLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT-YDEKCD 204 Query: 368 YWGLGCLIYEMIEGQSPFRGRKEK--VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLT 425 W G ++Y ++ G PF G+ E +KR E + + + + S++AK + + +LT Sbjct: 205 VWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRT--ISDDAKDLIRKMLT 262 Query: 426 KDAKQRLGCQEEGAAEVKRHPFFR 449 R+ A + HP+ + Sbjct: 263 FHPSLRI-----TATQCLEHPWIQ 281 >2Y7J-A nrPDB Length = 365 Score = 114 bits (286), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 84/274 (30%), Positives = 134/274 (48%), Gaps = 27/274 (9%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLE--KKRIKKRKGESM---ALNEKQILEKVNSQ- 244 V+G+G V C RATG +A K +E +R+ + E + E IL +V Sbjct: 101 VIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHP 160 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 ++ L +YE+ + LV +M G+L ++ +E R++ + +L + LH Sbjct: 161 HIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS--LLEAVSFLHA 218 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL------N 358 N V+RDLKPENILLDD IR+SD G + + G+ +R GT GY+APE+L Sbjct: 219 NNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDET 278 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH----KFSE 414 + YG D W G +++ ++ G PF R++ + + R ++E + +S S Sbjct: 279 HPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL----MLRMIMEGQYQFSSPEWDDRSS 334 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 K + LL D + RL A + +HPFF Sbjct: 335 TVKDLISRLLQVDPEARL-----TAEQALQHPFF 363 >4B6L-A nrPDB Length = 281 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 75/270 (27%), Positives = 125/270 (46%), Gaps = 12/270 (4%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P + T+ + R+LGKGGF TG YA K + + R+ K LNE ++ Sbjct: 5 PRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHR 64 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + + +V ++ +E D + + L + + L HI+ + E E +Y +IL GL Sbjct: 65 DLQHRHIVRFSHHFEDADNIYIFLELCSRKSLA-HIWKARHTLLEPE-VRYYLRQILSGL 122 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLN 358 + LH+ ++RDLK N + + +++ D GLA ++ P + GT Y+APEVL Sbjct: 123 KYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL 182 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 Q +G D W LGC++Y ++ G PF E +E R + + S A+ Sbjct: 183 RQGHGPEADVWSLGCVMYTLLCGSPPF----ETADLKETYRCIKQVHYTLPASLSLPARQ 238 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + +L + R ++ RH FF Sbjct: 239 LLAAILRASPRDR-----PSIDQILRHDFF 263 >2X4F-A nrPDB Length = 373 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 83/279 (29%), Positives = 137/279 (49%), Gaps = 16/279 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 T + +LG G FG+V C+ ATG A K ++ + +K ++ NE ++ +++ Sbjct: 90 TVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE---VKNEISVMNQLDHA 146 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 ++ L A+E+K+ + LV+ ++GG+L I + + E + + +I G+ +H+ Sbjct: 147 NLIQLYDAFESKNDIVLVMEYVDGGELFDRIID-ESYNLTELDTILFMKQICEGIRHMHQ 205 Query: 305 ENTVYRDLKPENILL--DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 ++ DLKPENIL D I+I D GLA + + ++ GT ++APEV+N Sbjct: 206 MYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFV 265 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRK--EKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 D W +G + Y ++ G SPF G E + R LE EE SEEAK Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF--QDISEEAKEFI 323 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNF-KRLEA 458 LL K+ R+ A+E +HP+ + RL A Sbjct: 324 SKLLIKEKSWRI-----SASEALKHPWLSDHKLHSRLSA 357 >5JZN-A nrPDB Length = 280 Score = 113 bits (282), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 83/271 (30%), Positives = 129/271 (47%), Gaps = 17/271 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++ R +G G F V C R+T + YA K ++K K R E M NE IL +V Sbjct: 21 YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKS--KCRGKEHMIQNEVSILRRVKHPN 78 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 +V L + L LV+ ++ GGDL I + + + Y + ++ LH Sbjct: 79 IVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLY--NLASAIKYLHSL 136 Query: 306 NTVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 N V+RD+KPEN+L+ D +++ D GLA I +G L GT Y+APE++ Sbjct: 137 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA-TIVDGPLYT-VCGTPTYVAPEIIAETG 194 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGR--KEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 YGL D W G + Y ++ G PFRG ++V +++ ++ Y S+ AK + Sbjct: 195 YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKEL 254 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 M+L D QR A +V HP+ + Sbjct: 255 ITMMLLVDVDQRF-----SAVQVLEHPWVND 280 >3LIJ-A nrPDB Length = 494 Score = 111 bits (278), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 83/288 (28%), Positives = 143/288 (49%), Gaps = 21/288 (7%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 +++ + LG G +GEV C+ + T A K + K + S L E +L+ ++ Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVS-TSSNSKLLEEVAVLKLLDHPN 97 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++ L +E K LV+ GG+L I + F E A ++L G+ LH+ Sbjct: 98 IMKLYDFFEDKRNYYLVMECYKGGELFDEIIH--RMKFNEVDAAVIIKQVLSGVTYLHKH 155 Query: 306 NTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 N V+RDLKPEN+LL+ I+I D GL+ ++ R+GT Y+APEVL ++Y Sbjct: 156 NIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL-RKKY 214 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH----KFSEEAKS 418 D W +G +++ ++ G PF G+ + +E+ R+V + + + SE AK Sbjct: 215 DEKCDVWSIGVILFILLAGYPPFGGQTD----QEILRKVEKGKYTFDSPEWKNVSEGAKD 270 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFV 466 + K +L D+++R+ Q + HP+ + M K+ E+G+ P Sbjct: 271 LIKQMLQFDSQRRISAQ-----QALEHPWIKEMCSKK-ESGIELPSLA 312 >2F57-A nrPDB Length = 317 Score = 110 bits (275), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 74/263 (28%), Positives = 129/263 (49%), Gaps = 21/263 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G G VC + TGK A K+++ ++ ++R+ + NE I+ + VV++ Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRE---LLFNEVVIMRDYHHDNVVDMYS 109 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 +Y D L +V+ + GG L + + EE+ +L L LH + ++RD Sbjct: 110 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 312 LKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG 370 +K ++ILL G I++SD G ++ E + VGT +MAPEV++ YG D W Sbjct: 167 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWS 226 Query: 371 LGCLIYEMIEGQSPFRG----RKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTK 426 LG ++ EMI+G+ P+ + + R+ + RV + HK S + ++L + Sbjct: 227 LGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDL-----HKVSSVLRGFLDLMLVR 281 Query: 427 DAKQRLGCQEEGAAEVKRHPFFR 449 + QR Q E+ HPF + Sbjct: 282 EPSQRATAQ-----ELLGHPFLK 299 >3LM0-A nrPDB Length = 327 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 85/275 (30%), Positives = 136/275 (49%), Gaps = 22/275 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS-QFVVNLA 250 LG+G F V C ++TG+ YA K L+K+R + + + L+E +LE S V+NL Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAEILHEIAVLELAKSCPRVINLH 95 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF----EEERALFYAAEILCGLEDLHREN 306 YE + L+L GG+ I+++ P E + +IL G+ LH+ N Sbjct: 96 EVYENTSEIILILEYAAGGE----IFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNN 151 Query: 307 TVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 V+ DLKP+NILL G I+I D G++ KI +R +GT Y+APE+LN Sbjct: 152 IVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPIT 211 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR-RVLETEEVYSHKFSEEAKSICKM 422 + D W +G + Y ++ SPF G + + + V +EE +S S+ A + Sbjct: 212 TATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFS-SVSQLATDFIQS 270 Query: 423 LLTKDAKQRLGCQEEGAAEV-KRHPFFRNMNFKRL 456 LL K+ ++R AE+ H + + +F+ L Sbjct: 271 LLVKNPEKR------PTAEICLSHSWLQQWDFENL 299 >4I6B-A nrPDB Length = 308 Score = 109 bits (273), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 73/270 (27%), Positives = 124/270 (45%), Gaps = 12/270 (4%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P T + + + LGKGGF + K+YA K + R+ K E ++ Sbjct: 24 PTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHR 83 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 ++ + VV + +E K+ + ++L + + HI E +Y +I+ GL Sbjct: 84 ILHHKHVVQFYHYFEDKENIYILLEYCSRRSMA-HILK-ARKVLTEPEVRYYLRQIVSGL 141 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLN 358 + LH + ++RDLK N +++ +++ D GLA ++ P R GT Y++PEVLN Sbjct: 142 KYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN 201 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 Q +G D W LGC++Y M+ G+ PF E +E R + E AK Sbjct: 202 KQGHGAESDIWALGCVMYTMLLGRPPF----ETTNLKETYRSIREARYTMPSSLLAPAKH 257 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + +L+K+ + R ++ RH FF Sbjct: 258 LIASMLSKNPEDR-----PSLDDIIRHDFF 282 >3Q5I-A nrPDB Length = 504 Score = 108 bits (271), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 81/267 (30%), Positives = 133/267 (49%), Gaps = 20/267 (7%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK----------RKGESMALNE 234 ++ + R LG G +GEV C+ + A K ++K + K K NE Sbjct: 37 SYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNE 96 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 +L+ ++ ++ L +E K LV GG+L I N F+E A + Sbjct: 97 ISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIIN--RHKFDECDAANIMKQ 154 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYG---HIRISDLGLAVKIPEGDLIRGRVGTVGY 351 IL G+ LH+ N V+RD+KPENILL++ +I+I D GL+ + +R R+GT Y Sbjct: 155 ILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYY 214 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK--VKREEVDRRVLETEEVYS 409 +APEVL ++Y D W G ++Y ++ G PF G+ ++ +K+ E + + + Sbjct: 215 IAPEVL-KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDW-- 271 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQE 436 S+EAK + K++LT D +R +E Sbjct: 272 KNISDEAKELIKLMLTYDYNKRCTAEE 298 >5ES1-A nrPDB Length = 328 Score = 108 bits (271), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 77/256 (30%), Positives = 129/256 (50%), Gaps = 9/256 (3%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 E QP N +R R +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 9 EEQPHVGN-YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKL-FREVR 66 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L LV+ + G++ ++ + G +E RA F +I+ Sbjct: 67 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKF--RQIV 124 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 + H++N V+RDLK EN+LLD +I+I+D G + + G + G+ Y APE+ Sbjct: 125 SAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPEL 184 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 ++Y G D W LG ++Y ++ G PF G K RE RVL + S + Sbjct: 185 FQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRE----RVLRGKYRVPFYMSTD 240 Query: 416 AKSICKMLLTKDAKQR 431 +SI + L + +R Sbjct: 241 CESILRRFLVLNPAKR 256 >1PHK-A nrPDB Length = 298 Score = 108 bits (271), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 80/273 (29%), Positives = 127/273 (46%), Gaps = 22/273 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM------ALNEKQILEKVNSQ 244 +LG+G V C + T K YA K ++ E + L E IL KV+ Sbjct: 24 ILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGH 83 Query: 245 -FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA-EILCGLEDL 302 ++ L YET LV +M G+L ++ +E R + A E++C L Sbjct: 84 PNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICAL--- 140 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL----- 357 H+ N V+RDLKPENILLDD +I+++D G + ++ G+ +R GT Y+APE++ Sbjct: 141 HKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMN 200 Query: 358 -NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 N+ YG D W G ++Y ++ G PF RK+ + + + +S+ Sbjct: 201 DNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTV 260 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 K + L ++R +E A HPFF+ Sbjct: 261 KDLVSRFLVVQPQKRYTAEEALA-----HPFFQ 288 >2YCR-A nrPDB Length = 323 Score = 108 bits (270), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 86/286 (30%), Positives = 141/286 (49%), Gaps = 22/286 (7%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKR--IKKRKGESMALN---EKQI 237 ++ + + LG G GEV R T K A K + K++ I + ALN E +I Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 L+K+N ++ + ++ +D +VL +M GG+L + +GN +E Y ++L Sbjct: 69 LKKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKV--VGNKRLKEATCKLYFYQMLL 125 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAP 354 ++ LH ++RDLKPEN+LL I+I+D G + + E L+R GT Y+AP Sbjct: 126 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAP 185 Query: 355 EVL---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV--KREEVDRRVLETEEVYS 409 EVL Y + D W LG +++ + G PF + +V K + + EV++ Sbjct: 186 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR 455 + SE+A + K LL D K R + E RHP+ ++ + KR Sbjct: 246 -EVSEKALDLVKKLLVVDPKARFTTE-----EALRHPWLQDEDMKR 285 >3I6U-A nrPDB Length = 419 Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 85/286 (29%), Positives = 141/286 (49%), Gaps = 22/286 (7%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKR--IKKRKGESMALN---EKQI 237 ++ + + LG G GEV R T K A + + K++ I + ALN E +I Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 L+K+N ++ + ++ +D +VL +M GG+L + +GN +E Y ++L Sbjct: 194 LKKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKV--VGNKRLKEATCKLYFYQMLL 250 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAP 354 ++ LH ++RDLKPEN+LL I+I+D G + + E L+R GT Y+AP Sbjct: 251 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAP 310 Query: 355 EVL---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV--KREEVDRRVLETEEVYS 409 EVL Y + D W LG +++ + G PF + +V K + + EV++ Sbjct: 311 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR 455 + SE+A + K LL D K R + E RHP+ ++ + KR Sbjct: 371 -EVSEKALDLVKKLLVVDPKARFTTE-----EALRHPWLQDEDMKR 410 >3H4J-B nrPDB Length = 336 Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 78/263 (29%), Positives = 130/263 (49%), Gaps = 14/263 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G FG+V T + A K + ++ +KK E L+ + ++ L Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYD 76 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 T + +V+ GG+L +I +E R F +I+C +E HR V+RD Sbjct: 77 VITTPTDIVMVIE-YAGGELFDYIVEKKRMTEDEGRRFF--QQIICAIEYCHRHKIVHRD 133 Query: 312 LKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYWG 370 LKPEN+LLDD +++I+D GL+ + +G+ ++ G+ Y APEV+N + Y G D W Sbjct: 134 LKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWS 193 Query: 371 LGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ 430 G ++Y M+ G+ PF ++V+ V V S A+S+ + ++ D Q Sbjct: 194 CGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVY----VMPDFLSPGAQSLIRRMIVADPMQ 249 Query: 431 RLGCQEEGAAEVKRHPFFRNMNF 453 R+ Q E++R P+F N+N Sbjct: 250 RITIQ-----EIRRDPWF-NVNL 266 >4D28-A nrPDB Length = 446 Score = 107 bits (267), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 86/291 (29%), Positives = 137/291 (47%), Gaps = 24/291 (8%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R +G+G F +V + TG A K + K I K + E I++ V +V L Sbjct: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 +K + +VL + GG+L I + G +E R F +++ + H + + Sbjct: 75 YEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYF--QQLVDAVAHCHSKGVYH 132 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRVGTVGYMAPEVLNNQRY-GLSPD 367 RDLKPEN+LLD G++++SD GL+ EG +L+ GT Y+APEVL+ Q Y G + D Sbjct: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGSAAD 192 Query: 368 YWGLGCLIYEMIEGQSPFR-----GRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKM 422 W G +++ ++ G PF G K+ E D FS E K + Sbjct: 193 IWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFD---------CPPWFSAEVKFLIHR 243 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVY 473 +L + K R+ Q +K+ P+FR N+ + A + + D RAV+ Sbjct: 244 ILDPNPKTRIQIQ-----GIKKDPWFRK-NYVPIRAREEEEVNLDDIRAVF 288 >3D2K-A nrPDB Length = 272 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 75/260 (28%), Positives = 119/260 (45%), Gaps = 12/260 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R LGKG FG V + R + + A K L K +++K E E +I + ++ L Sbjct: 18 RPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRL 77 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 + + L+L G + + + F+E+R Y E+ L H + ++ Sbjct: 78 YGYFHDATRVYLILEYAPLGTVYRELQKLSR--FDEQRTATYITELANALSYCHSKRVIH 135 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYW 369 RD+KPEN+LL G ++I+D G +V P GT+ Y+ PE++ + + D W Sbjct: 136 RDIKPENLLLGSNGELKIADFGWSVHAPSSRRT-TLCGTLDYLPPEMIEGRMHDEKVDLW 194 Query: 370 GLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAK 429 LG L YE + G PF E +E RR+ E + +E A+ + LL +A Sbjct: 195 SLGVLCYEFLVGMPPF----EAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNAS 250 Query: 430 QRLGCQEEGAAEVKRHPFFR 449 QRL AEV HP+ + Sbjct: 251 QRLTL-----AEVLEHPWIK 265 >4REW-A nrPDB Length = 540 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 64/196 (32%), Positives = 103/196 (52%), Gaps = 3/196 (1%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 LG G FG+V + TG A K L +++I+ E Q L+ ++ L Sbjct: 13 TLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 72 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 T + +V+ ++GG+L +I G +E R LF +IL G++ HR V+R Sbjct: 73 QVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF--QQILSGVDYCHRHMVVHR 130 Query: 311 DLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYW 369 DLKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Y G D W Sbjct: 131 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 190 Query: 370 GLGCLIYEMIEGQSPF 385 G ++Y ++ G PF Sbjct: 191 SSGVILYALLCGTLPF 206 >5TQX-A nrPDB Length = 655 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 75/206 (36%), Positives = 103/206 (50%), Gaps = 17/206 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACK--RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 LG GGFG VC Q R A K RLE K +E QI++K+N VV Sbjct: 16 LGTGGFGNVCLYQHRELDLKIAIKSCRLELST----KNRERWCHEIQIMKKLNHANVVKA 71 Query: 250 AYAYE-----TKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGLEDLH 303 E D L + +GGDL+ + N G +E + L ++I G+ LH Sbjct: 72 CDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLH 131 Query: 304 RENTVYRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 ++RDLKPENI+L D G H +I DLG A + +G+L VGT+ Y+APE+ N Sbjct: 132 ENKIIHRDLKPENIVLQDVGGKIIH-KIIDLGYAKDVDQGELCTEFVGTLQYLAPELFEN 190 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPF 385 + Y + DYW G +++E I G PF Sbjct: 191 KPYTATVDYWSFGTMVFECIAGYRPF 216 >4CFH-A nrPDB Length = 493 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 64/195 (32%), Positives = 103/195 (52%), Gaps = 3/195 (1%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG G FG+V + TG A K L +++I+ E Q L+ ++ L Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 100 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 T + +V+ ++GG+L +I G +E R LF +IL G++ HR V+RD Sbjct: 101 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF--QQILSGVDYCHRHMVVHRD 158 Query: 312 LKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYWG 370 LKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Y G D W Sbjct: 159 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 218 Query: 371 LGCLIYEMIEGQSPF 385 G ++Y ++ G PF Sbjct: 219 SGVILYALLCGTLPF 233 >4JXF-A nrPDB Length = 266 Score = 105 bits (263), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 78/265 (29%), Positives = 128/265 (48%), Gaps = 13/265 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F+ +LGKG F V + TG A K ++KK + K NE +I ++ Sbjct: 9 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 68 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++ L +E + + LVL + + G++ ++ N P F E A + +I+ G+ LH Sbjct: 69 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKP-FSENEARHFMHQIITGMLYLHSH 127 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLA--VKIPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 ++RDL N+LL +I+I+D GLA +K+P + GT Y++PE+ +G Sbjct: 128 GILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPH-EKHYTLCGTPNYISPEIATRSAHG 186 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 L D W LGC+ Y ++ G+ PF + +++ VL E+ S S EAK + L Sbjct: 187 LESDVWSLGCMFYTLLIGRPPF---DTDTVKNTLNKVVLADYEMPSF-LSIEAKDLIHQL 242 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFF 448 L ++ RL + V HPF Sbjct: 243 LRRNPADRLSL-----SSVLDHPFM 262 >5FG8-A nrPDB Length = 285 Score = 105 bits (263), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 75/262 (28%), Positives = 129/262 (49%), Gaps = 14/262 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LGKG F V C ++TG +A K + K++ R + + E +I K++ +V L Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLE-REARICRKLHHPNIVRLHD 80 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 + + ++ LV ++ GG+L I + + E A +IL + H+ V+RD Sbjct: 81 SIQEENYHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESVNHCHQNGVVHRD 138 Query: 312 LKPENILLDDYGH---IRISDLGLAVKIPEGD--LIRGRVGTVGYMAPEVLNNQRYGLSP 366 LKPEN+LL ++++D GLA+++ +GD G GT GY++PEVL + YG S Sbjct: 139 LKPENLLLASKAKGAAVKLADFGLAIEV-QGDHQAWFGFAGTPGYLSPEVLKKEPYGKSV 197 Query: 367 DYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTK 426 D W G ++Y ++ G PF + ++ + + EAK++ +LT Sbjct: 198 DIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTV 257 Query: 427 DAKQRLGCQEEGAAEVKRHPFF 448 + +R+ AAE +HP+ Sbjct: 258 NPNKRI-----TAAEALKHPWI 274 >5KZ7-A nrPDB Length = 346 Score = 105 bits (262), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 70/224 (31%), Positives = 119/224 (53%), Gaps = 5/224 (2%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + QP N +R + +GKG F +V + TGK A K ++K ++ + + E + Sbjct: 27 DEQPHIGN-YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL-FREVR 84 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L LV+ +GG++ ++ G +E RA F +I+ Sbjct: 85 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 142 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 ++ H++ V+RDLK EN+LLD +I+I+D G + + G+ + G+ Y APE+ Sbjct: 143 SAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPEL 202 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 ++Y G D W LG ++Y ++ G PF G+ K RE V R Sbjct: 203 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 246 >6CMJ-A nrPDB Length = 321 Score = 105 bits (262), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 77/273 (28%), Positives = 133/273 (48%), Gaps = 30/273 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM--------ALNEKQILEKVNS 243 +GKG +G V YA K L KK++ ++ G + E IL+K++ Sbjct: 42 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKKLDH 101 Query: 244 QFVVNLAYAYE--TKDALCLVLTIMNGGDLKFHIYNMGNPGFE---EERALFYAAEILCG 298 VV L + +D L +V ++N G + M P + E++A FY +++ G Sbjct: 102 PNVVKLVEVLDDPNEDHLYMVFELVNQGPV------MEVPTLKPLSEDQARFYFQDLIKG 155 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVL 357 +E LH + ++RD+KP N+L+ + GHI+I+D G++ + D L+ VGT +MAPE L Sbjct: 156 IEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESL 215 Query: 358 NNQR---YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE 414 + R G + D W +G +Y + GQ PF + ++ + LE + +E Sbjct: 216 SETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD--QPDIAE 273 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 + K + +L K+ + R+ E+K HP+ Sbjct: 274 DLKDLITRMLDKNPESRI-----VVPEIKLHPW 301 >4RED-A nrPDB Length = 351 Score = 105 bits (262), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 64/195 (32%), Positives = 103/195 (52%), Gaps = 3/195 (1%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG G FG+V + TG A K L +++I+ E Q L+ ++ L Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 T + +V+ ++GG+L +I G +E R LF +IL G++ HR V+RD Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF--QQILSGVDYCHRHMVVHRD 139 Query: 312 LKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYWG 370 LKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Y G D W Sbjct: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 371 LGCLIYEMIEGQSPF 385 G ++Y ++ G PF Sbjct: 200 SGVILYALLCGTLPF 214 >2WQN-A nrPDB Length = 310 Score = 104 bits (260), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 72/259 (27%), Positives = 122/259 (47%), Gaps = 16/259 (6%) Query: 184 NTFRQYRV---LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 NT +R+ +G+G F EV G A K+++ + K + + E +L++ Sbjct: 29 NTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQ 88 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG-FEEERALF-YAAEILCG 298 +N V+ ++ + L +VL + + GDL I + ER ++ Y ++ Sbjct: 89 LNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSA 148 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVL 357 LE +H ++RD+KP N+ + G +++ DLGL + VGT YM+PE + Sbjct: 149 LEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV-----KREEVDRRVLETEEVYSHKF 412 + Y D W LGCL+YEM QSPF G K + K E+ D L ++ + Sbjct: 209 HENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDH-----Y 263 Query: 413 SEEAKSICKMLLTKDAKQR 431 SEE + + M + D ++R Sbjct: 264 SEELRQLVNMCINPDPEKR 282 >5IG1-A nrPDB Length = 344 Score = 104 bits (259), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 76/266 (28%), Positives = 130/266 (48%), Gaps = 21/266 (7%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 V+GKG F V C + TG++ A K + K ++ + + E I + + +V++ Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIK-REIGICSSLQHEHIVSMR 82 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 A+ + LV ++GG+L I + + E+ A +IL L+ H +N ++R Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEI--VTRKFYNEKDASACMHQILSALQHCHSKNIIHR 140 Query: 311 DLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD 367 DLKPEN+LL D ++I+D GLAV + +G G GT GY++PEV+ Y + D Sbjct: 141 DLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPYDTAVD 200 Query: 368 YWGLGCLIYEMIEGQSPF-----RGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKM 422 W G ++Y ++ G PF + ++K + D E + V + AK + K Sbjct: 201 VWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSV-----TTAAKELIKA 255 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFF 448 +L + K+R Q E+ +HP+ Sbjct: 256 MLEPNPKRRPTVQ-----ELLQHPWI 276 >6C9D-A nrPDB Length = 459 Score = 103 bits (258), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 69/224 (30%), Positives = 119/224 (53%), Gaps = 5/224 (2%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 15 DEQPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKL-FREVR 72 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L LV+ +GG++ ++ G +E RA F +I+ Sbjct: 73 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 130 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 ++ H++ V+RDLK EN+LLD +I+I+D G + + G+ + G+ Y APE+ Sbjct: 131 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPEL 190 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 ++Y G D W LG ++Y ++ G PF G+ K RE V R Sbjct: 191 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 234 >2HAK-A nrPDB Length = 328 Score = 103 bits (258), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 69/224 (30%), Positives = 119/224 (53%), Gaps = 5/224 (2%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 9 DEQPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKL-FREVR 66 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L LV+ +GG++ ++ G +E RA F +I+ Sbjct: 67 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 124 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 ++ H++ V+RDLK EN+LLD +I+I+D G + + G+ + G+ Y APE+ Sbjct: 125 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPEL 184 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 ++Y G D W LG ++Y ++ G PF G+ K RE V R Sbjct: 185 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 228 >5EZV-A nrPDB Length = 560 Score = 103 bits (256), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 63/196 (32%), Positives = 101/196 (51%), Gaps = 3/196 (1%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 LG G FG+V + + TG A K L +++I+ E Q L+ ++ L Sbjct: 35 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 94 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 T +V+ ++GG+L +I G E R LF +IL ++ HR V+R Sbjct: 95 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF--QQILSAVDYCHRHMVVHR 152 Query: 311 DLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYW 369 DLKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Y G D W Sbjct: 153 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 212 Query: 370 GLGCLIYEMIEGQSPF 385 G ++Y ++ G PF Sbjct: 213 SCGVILYALLCGTLPF 228 >4CZT-A nrPDB Length = 464 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 122/251 (48%), Gaps = 10/251 (3%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R LG+G F +V + G A K ++K+++ K K + E ++ + V+ + Sbjct: 17 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 76 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 +K + VL + GG+L I + G +E+ A Y +++ ++ H + Sbjct: 77 FEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYCHSRGVYH 134 Query: 310 RDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLS 365 RDLKPEN+LLD G +++SD GL+ ++ E L+ GT Y+APEV+NN+ Y G Sbjct: 135 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 194 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLT 425 D W G +++ ++ G PF E + +++ + E FS AK + K +L Sbjct: 195 ADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRILD 250 Query: 426 KDAKQRLGCQE 436 + R+ E Sbjct: 251 PNPATRITFAE 261 >4CFF-A nrPDB Length = 571 Score = 102 bits (255), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 63/196 (32%), Positives = 101/196 (51%), Gaps = 3/196 (1%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 LG G FG+V + + TG A K L +++I+ E Q L+ ++ L Sbjct: 40 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 99 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 T +V+ ++GG+L +I G E R LF +IL ++ HR V+R Sbjct: 100 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF--QQILSAVDYCHRHMVVHR 157 Query: 311 DLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYW 369 DLKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Y G D W Sbjct: 158 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 217 Query: 370 GLGCLIYEMIEGQSPF 385 G ++Y ++ G PF Sbjct: 218 SCGVILYALLCGTLPF 233 >4KIK-B nrPDB Length = 677 Score = 102 bits (254), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 80/241 (33%), Positives = 113/241 (46%), Gaps = 22/241 (9%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV---- 247 LG GGFG V + TG+ A K+ ++ + R E L E QI+ ++ VV Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCL-EIQIMRRLTHPNVVAARD 84 Query: 248 ------NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGLE 300 NLA D L + GGDL+ ++ N G E L ++I L Sbjct: 85 VPEGMQNLA----PNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 301 DLHRENTVYRDLKPENILLDDYGHIR----ISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 LH ++RDLKPENI+L G R I DLG A ++ +G L VGT+ Y+APE+ Sbjct: 141 YLHENRIIHRDLKPENIVLQQ-GEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 L Q+Y ++ DYW G L +E I G PF + V+ R+ E + V S + Sbjct: 200 LEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTV 259 Query: 417 K 417 K Sbjct: 260 K 260 >1KOA-A nrPDB Length = 491 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 125/288 (43%), Gaps = 27/288 (9%) Query: 163 DSMFFDRFLQWKWLERQPVT---KNTFRQYRV---LGKGGFGEVCACQVRATGKMYACKR 216 D+ FD WK QPV + Y + LG G FG V RATG +A K Sbjct: 27 DNYVFD---IWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKF 83 Query: 217 L------EKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGD 270 + +K+ ++K E Q + + +VNL A+E + + ++ M+GG+ Sbjct: 84 VMTPHESDKETVRK---------EIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGE 134 Query: 271 LKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD--YGHIRIS 328 L + + N E+E A+ Y ++ GL +H N V+ DLKPENI+ +++ Sbjct: 135 LFEKVADEHNKMSEDE-AVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLI 193 Query: 329 DLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 D GL + ++ GT + APEV + G D W +G L Y ++ G SPF G Sbjct: 194 DFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGE 253 Query: 389 KEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + V ++ SE+ K + LL D R+ + Sbjct: 254 NDDETLRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQ 301 >5YKS-A nrPDB Length = 377 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 68/265 (25%), Positives = 130/265 (49%), Gaps = 13/265 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 + LG+G F V + TG+ A K ++K ++ + E + ++ V +V L Sbjct: 41 KTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHL-FQEVRCMKLVQHPNIVRL 99 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 +T+ L L+L + +GGD+ F G E+ A Y A+I+ + H+ + V+ Sbjct: 100 YEVIDTQTKLYLILELGDGGDM-FDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVH 158 Query: 310 RDLKPENIL-LDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL-SPD 367 RDLKPEN++ + G ++++D G + K G + G++ Y APE+L Y + D Sbjct: 159 RDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVD 218 Query: 368 YWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKD 427 W LG +++ ++ GQ PF ++ E +++ + S+E K + +L +D Sbjct: 219 IWSLGVILFMLVCGQPPF----QEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 274 Query: 428 AKQRLGCQEEGAAEVKRHPFFRNMN 452 K+R + E++ HP+ + ++ Sbjct: 275 PKRRASLE-----EIENHPWLQGVD 294 >2QNJ-A nrPDB Length = 328 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 118/224 (52%), Gaps = 5/224 (2%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 6 DEQPHIGN-YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKL-FREVR 63 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L L++ +GG++ ++ G +E R+ F +I+ Sbjct: 64 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKF--RQIV 121 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 ++ H++ V+RDLK EN+LLD +I+I+D G + + G + G+ Y APE+ Sbjct: 122 SAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPEL 181 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 ++Y G D W LG ++Y ++ G PF G+ K RE V R Sbjct: 182 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 225 >3UTO-A nrPDB Length = 573 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 125/288 (43%), Gaps = 27/288 (9%) Query: 163 DSMFFDRFLQWKWLERQPVT---KNTFRQYRV---LGKGGFGEVCACQVRATGKMYACKR 216 D+ FD WK QPV + Y + LG G FG V RATG +A K Sbjct: 133 DNYVFD---IWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKF 189 Query: 217 L------EKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGD 270 + +K+ ++K E Q + + +VNL A+E + + ++ M+GG+ Sbjct: 190 VMTPHESDKETVRK---------EIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGE 240 Query: 271 LKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD--YGHIRIS 328 L + + N E+E A+ Y ++ GL +H N V+ DLKPENI+ +++ Sbjct: 241 LFEKVADEHNKMSEDE-AVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLI 299 Query: 329 DLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 D GL + ++ GT + APEV + G D W +G L Y ++ G SPF G Sbjct: 300 DFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGE 359 Query: 389 KEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + V ++ SE+ K + LL D R+ + Sbjct: 360 NDDETLRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQ 407 >2YZA-A nrPDB Length = 276 Score = 100 bits (249), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 63/195 (32%), Positives = 101/195 (51%), Gaps = 3/195 (1%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG G FG+V + + TG A K L +++I+ E Q L+ ++ L Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 T +V+ ++GG+L +I G E R LF +IL ++ HR V+RD Sbjct: 79 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF--QQILSAVDYCHRHMVVHRD 136 Query: 312 LKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYWG 370 LKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Y G D W Sbjct: 137 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVDIWS 196 Query: 371 LGCLIYEMIEGQSPF 385 G ++Y ++ G PF Sbjct: 197 CGVILYALLCGTLPF 211 >3KK8-A nrPDB Length = 284 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 67/248 (27%), Positives = 116/248 (46%), Gaps = 6/248 (2%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LGKG F V C + TG +A K + K++ R + + E +I K+ +V L Sbjct: 14 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE-REARICRKLQHPNIVRLHD 72 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 + + + LV ++ GG+L I + + E A +IL + H V+R+ Sbjct: 73 SIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESIAYCHSNGIVHRN 130 Query: 312 LKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDY 368 LKPEN+LL ++++D GLA+++ + + G GT GY++PEVL Y D Sbjct: 131 LKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDI 190 Query: 369 WGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDA 428 W G ++Y ++ G PF + ++ + + EAKS+ +LT + Sbjct: 191 WACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNP 250 Query: 429 KQRLGCQE 436 K+R+ + Sbjct: 251 KKRITADQ 258 >2W4O-A nrPDB Length = 349 Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 80/277 (28%), Positives = 130/277 (46%), Gaps = 24/277 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G V C+ + T K YA K L+K KK + E +L +++ ++ L Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKK-----IVRTEIGVLLRLSHPNIIKLKE 115 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 +ET + LVL ++ GG+L I G + E A +IL + LH V+RD Sbjct: 116 IFETPTEISLVLELVTGGELFDRIVEKGY--YSERDAADAVKQILEAVAYLHENGIVHRD 173 Query: 312 LKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDY 368 LKPEN+L ++I+D GL+ + L++ GT GY APE+L YG D Sbjct: 174 LKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDM 233 Query: 369 WGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE----AKSICKMLL 424 W +G + Y ++ G PF + + + RR+L E + + +E AK + + L+ Sbjct: 234 WSVGIITYILLCGFEPFYDERGD---QFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLI 290 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFF--RNMNFKRLEAG 459 D K+RL + +HP+ + NF ++ Sbjct: 291 VLDPKKRL-----TTFQALQHPWVTGKAANFVHMDTA 322 >2BDW-A nrPDB Length = 362 Score = 99.4 bits (246), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 67/248 (27%), Positives = 116/248 (46%), Gaps = 6/248 (2%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LGKG F V C + TG +A K + K++ R + + E +I K+ +V L Sbjct: 37 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE-REARICRKLQHPNIVRLHD 95 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 + + + LV ++ GG+L I + + E A +IL + H V+R+ Sbjct: 96 SIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESIAYCHSNGIVHRN 153 Query: 312 LKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDY 368 LKPEN+LL ++++D GLA+++ + + G GT GY++PEVL Y D Sbjct: 154 LKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDI 213 Query: 369 WGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDA 428 W G ++Y ++ G PF + ++ + + EAKS+ +LT + Sbjct: 214 WACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNP 273 Query: 429 KQRLGCQE 436 K+R+ + Sbjct: 274 KKRITADQ 281 >5YV8-A nrPDB Length = 298 Score = 98.6 bits (244), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 77/288 (26%), Positives = 132/288 (45%), Gaps = 45/288 (15%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG-----------------------E 228 +GKG +G V YA K L KK++ ++ G Sbjct: 21 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPI 80 Query: 229 SMALNEKQILEKVNSQFVVNLAYAYE--TKDALCLVLTIMNGGDLKFHIYNMGNPGFE-- 284 E IL+K++ VV L + +D L +V ++N G + M P + Sbjct: 81 EQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV------MEVPTLKPL 134 Query: 285 -EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LI 342 E++A FY +++ G+E LH + ++RD+KP N+L+ + GHI+I+D G++ + D L+ Sbjct: 135 SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALL 194 Query: 343 RGRVGTVGYMAPEVLNNQR---YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 VGT +MAPE L+ R G + D W +G +Y + GQ PF + ++ Sbjct: 195 SNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKS 254 Query: 400 RVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 + LE + +E+ K + +L K+ + R+ E+K HP+ Sbjct: 255 QALEFPD--QPDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPW 295 >4MVF-A nrPDB Length = 506 Score = 98.2 bits (243), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 78/267 (29%), Positives = 129/267 (48%), Gaps = 22/267 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G +G V + T ++YA K +K R+K + E +I++K++ +V L Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI---NRFFQEIEIMKKLDHPNIVKLYE 121 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 YE + + L++ + +G +L I + N F E+ A +I + LH N V+RD Sbjct: 122 TYENDNYIYLIMELCSGRELFDSI--IENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRD 179 Query: 312 LKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDY 368 LKPEN L ++I D GL+ + G+ + GT Y+AP+VL+ +Y D Sbjct: 180 LKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-KYDKKCDI 238 Query: 369 WGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK----FSEEAKSICKMLL 424 W G ++Y ++ G PF G + EV ++V + E + S +AK++ LL Sbjct: 239 WSSGVIMYTLLCGYPPFYGDTDN----EVLKKVKKGEFCFYENDWGSISSDAKNLITKLL 294 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFFRNM 451 T + +R C E E HP+ M Sbjct: 295 TYNPNER--CTIE---EALNHPWITQM 316 >3MN3-A nrPDB Length = 271 Score = 98.2 bits (243), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 68/253 (26%), Positives = 120/253 (47%), Gaps = 8/253 (3%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 ++ + LG+G FG+V TG+ A K + KK + K + E L + Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 ++ L ++KD + +V+ G +L +I +E R F +I+ +E HR Sbjct: 65 HIIKLYDVIKSKDEIIMVIE-YAGNELFDYIVQRDKMSEQEARRFF--QQIISAVEYCHR 121 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-G 363 V+RDLKPEN+LLD++ +++I+D GL+ + +G+ ++ G+ Y APEV++ + Y G Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 D W G ++Y M+ + PF V + + V + S A + K + Sbjct: 182 PEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKF----LSPGAAGLIKRM 237 Query: 424 LTKDAKQRLGCQE 436 L + R+ E Sbjct: 238 LIVNPLNRISIHE 250 >4YNZ-A nrPDB Length = 342 Score = 98.2 bits (243), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 74/252 (29%), Positives = 122/252 (48%), Gaps = 16/252 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRK-GESMALN---EKQILEKV 241 +R + LGKG G V+ C+++ K + + K ES+ + E IL+ + Sbjct: 12 YRLEKTLGKGQTG-----LVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLI 66 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 V+ L YE K L LVL ++GG+L ++ G +E R F +I+ L+ Sbjct: 67 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFF--RQIISALDF 124 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 H + +RDLKPEN+LLD+ +IRI+D G+A L+ G+ Y PEV+ ++ Sbjct: 125 CHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEK 184 Query: 362 Y-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y G D W G +++ ++ G PF + E+V R V H + +S+ Sbjct: 185 YDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHM----PHFIPPDCQSLL 240 Query: 421 KMLLTKDAKQRL 432 + ++ DA +RL Sbjct: 241 RGMIEVDAARRL 252 >4KS7-A nrPDB Length = 292 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 69/261 (26%), Positives = 125/261 (47%), Gaps = 13/261 (4%) Query: 189 YRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVN 248 Y +G+G G VC + + +G+ A K ++ ++ ++R+ + NE I+ VV Sbjct: 28 YVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRE---LLFNEVVIMRDYQHFNVVE 84 Query: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV 308 + +Y + L +++ + GG L + + EE+ +L L LH + + Sbjct: 85 MYKSYLVGEELWVLMEFLQGGALTDIVSQVR---LNEEQIATVCEAVLQALAYLHAQGVI 141 Query: 309 YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRVGTVGYMAPEVLNNQRYGLSPD 367 +RD+K ++ILL G +++SD G +I + R VGT +MAPEV++ Y D Sbjct: 142 HRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVD 201 Query: 368 YWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKD 427 W LG ++ EM++G+ P+ V+ + R + SHK S + + +L +D Sbjct: 202 IWSLGIMVIEMVDGEPPYFS-DSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRD 260 Query: 428 AKQRLGCQEEGAAEVKRHPFF 448 ++R Q E+ HPF Sbjct: 261 PQERATAQ-----ELLDHPFL 276 >2VN9-A nrPDB Length = 301 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 73/270 (27%), Positives = 125/270 (46%), Gaps = 14/270 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + ++ + LGKG F V C TG+ YA K + K++ R + + E +I + Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE-REARICRLLKH 62 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + + LV ++ GG+L I + + E A +IL + H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILESVNHCH 120 Query: 304 RENTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGD--LIRGRVGTVGYMAPEVLN 358 V+RDLKPEN+LL ++++D GLA+++ +GD G GT GY++PEVL Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEV-QGDQQAWFGFAGTPGYLSPEVLR 179 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 YG D W G ++Y ++ G PF + +++ + + EAK Sbjct: 180 KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 239 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + +LT + +R+ A+E +HP+ Sbjct: 240 LINKMLTINPAKRI-----TASEALKHPWI 264 >4UZD-A nrPDB Length = 287 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 117/259 (45%), Gaps = 12/259 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R LGKG FG V + + + + A K L K +++K E E +I + ++ L Sbjct: 14 RPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRL 73 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 + + L+L G + + + F+E+R Y E+ L H + ++ Sbjct: 74 YGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIH 131 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYW 369 RD+KPEN+LL G ++I+D G +V P GT+ Y+ PE++ + + D W Sbjct: 132 RDIKPENLLLGSAGELKIADFGWSVHAPSSRRT-TLCGTLDYLPPEMIEGRMHDEKVDLW 190 Query: 370 GLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAK 429 LG L YE + G+ PF E +E +R+ E + +E A+ + LL + Sbjct: 191 SLGVLCYEFLVGKPPF----EANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPS 246 Query: 430 QRLGCQEEGAAEVKRHPFF 448 QR + EV HP+ Sbjct: 247 QRPMLR-----EVLEHPWI 260 >4NIF-A nrPDB Length = 333 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 83/266 (31%), Positives = 123/266 (46%), Gaps = 23/266 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 +G G + E C +AT YA K ++K K+ E + + +L ++ L Sbjct: 15 TIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI----LLRYGQHPNIITLK 68 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 Y+ + LV +M GG+L I + F E A F I +E LH + V+R Sbjct: 69 DVYDDGKHVYLVTELMRGGELLDKI--LRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 126 Query: 311 DLKPENIL-LDDYGH---IRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNNQRYGLS 365 DLKP NIL +D+ G+ +RI D G A ++ E L+ T ++APEVL Q Y Sbjct: 127 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 186 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS----HKFSEEAKSICK 421 D W LG L+Y M+ G +PF EE+ R+ + S + SE AK + Sbjct: 187 CDIWSLGILLYTMLAGYTPFANGPSDTP-EEILTRIGSGKFTLSGGNWNTVSETAKDLVS 245 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPF 447 +L D QRL A +V +HP+ Sbjct: 246 KMLHVDPHQRL-----TAKQVLQHPW 266 >3BHH-A nrPDB Length = 295 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 73/269 (27%), Positives = 126/269 (46%), Gaps = 14/269 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + ++ Y +GKG F V C TG YA K + K++ R + + E +I + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLE-REARICRLLKH 62 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + + LV ++ GG+L I + + E A +IL + H Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCH 120 Query: 304 RENTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGD--LIRGRVGTVGYMAPEVLN 358 + V+RDLKPEN+LL ++++D GLA+++ +GD G GT GY++PEVL Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEV-QGDQQAWFGFAGTPGYLSPEVLR 179 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + YG D W G ++Y ++ G PF + +++ + + EAK+ Sbjct: 180 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 239 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 + +LT + +R+ A E +HP+ Sbjct: 240 LINQMLTINPAKRI-----TAHEALKHPW 263 >3ZDU-A nrPDB Length = 325 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 64/205 (31%), Positives = 104/205 (50%), Gaps = 15/205 (7%) Query: 185 TFRQYRVLGK---GGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + Y LGK G +G V C+ + TG++ A K ++ ++ +A+ E + L++ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYER--PEQSVNKIAMREIKFLKQF 58 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNG---GDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + + +VNL + K + LV ++ +L+ + + G E +R Y +IL Sbjct: 59 HHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCH-----GLESKRLRKYLFQILRA 113 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE-GDLIRGRVGTVGYMAPE-V 356 ++ LH N ++RD+KPENIL+ G ++ D G A + GD+ V T Y APE V Sbjct: 114 IDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELV 173 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEG 381 L + YG D W LGC+I EM G Sbjct: 174 LKDTSYGKPVDIWALGCMIIEMATG 198 >4B8L-A nrPDB Length = 286 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 75/287 (26%), Positives = 132/287 (45%), Gaps = 17/287 (5%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 + ++ T + F R LGKG FG V + + + A K L K +++K E E Sbjct: 7 MPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREI 66 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 +I + ++ + + + + L+L G+L + G F+E+R+ + E+ Sbjct: 67 EIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGR--FDEQRSATFMEEL 124 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV--GTVGYMA 353 L H ++RD+KPEN+L+ G ++I+D G +V P +R R GT+ Y+ Sbjct: 125 ADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPS---LRRRTMCGTLDYLP 181 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 PE++ + + D W G L YE + G PF + E RR++ + + S Sbjct: 182 PEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPF----DSPSHTETHRRIVNVDLKFPPFLS 237 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGM 460 + +K + LL QRL + G E HP+ + N +R+ G+ Sbjct: 238 DGSKDLISKLLRYHPPQRLPLK--GVME---HPWVK-ANSRRVLPGV 278 >4CQG-A nrPDB Length = 331 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 66/207 (31%), Positives = 110/207 (53%), Gaps = 15/207 (7%) Query: 186 FRQYRVLGKGGFGEV-CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI--LEKVN 242 + Y +G GGF +V AC V TG+M A K ++K + G + + +I L+ + Sbjct: 11 YELYETIGTGGFAKVKLACHV-LTGEMVAIKIMDKNAL----GSDLPRVKTEIDALKSLR 65 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 Q + L + ETK+ + +VL GG+L +I + EE R +F +IL + + Sbjct: 66 HQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVF--RQILSAVAYV 123 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---LIRGRVGTVGYMAPEVLNN 359 H + +RDLKPEN+L D+ +++ D GL K P+G+ ++ G++ Y APE++ Sbjct: 124 HSQGYAHRDLKPENLLFDENHKLKLIDFGLCAK-PKGNKDYHLQECCGSLAYAAPELIQG 182 Query: 360 QRY-GLSPDYWGLGCLIYEMIEGQSPF 385 + Y G D W +G L+Y ++ G PF Sbjct: 183 KSYLGSEADVWSMGILLYVLMCGFLPF 209 >5DBX-A nrPDB Length = 328 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 82/289 (28%), Positives = 135/289 (46%), Gaps = 26/289 (8%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P+ ++ + V+G G V A + + A KR+ ++ + E L E Q + Sbjct: 7 PICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDE--LLKEIQAMS 64 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGG---DLKFHIYNMG---NPGFEEERALFYAA 293 + + VV ++ KD L LV+ +++GG D+ +I N G N EE Sbjct: 65 QCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK 124 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE-GDLIRGR-----VG 347 E+L GL+ LHR ++RDLK NILL + G ++I+D G++ + GD+ R + VG Sbjct: 125 EVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVG 184 Query: 348 TVGYMAPEVLNNQR-YGLSPDYWGLGCLIYEMIEGQSPFRG---RKEKVKREEVDRRVLE 403 T +MAPEV+ R Y D W G E+ G +P+ K + + D LE Sbjct: 185 TPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLE 244 Query: 404 T---EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 T ++ K+ + + + + L KD +R AAE+ + FF+ Sbjct: 245 TGVEDKEMMKKYGKSFRKLLSLCLQKDPSKR-----PTAAELLKCKFFQ 288 >3Q53-A nrPDB Length = 306 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 61/204 (29%), Positives = 103/204 (50%), Gaps = 7/204 (3%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 K + ++ +G+G G V ATG+ A +++ ++ K++ + +NE ++ + Sbjct: 20 KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKE---LIINEILVMRENK 76 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 + +VN +Y D L +V+ + GG L + +E + E L LE L Sbjct: 77 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALEFL 133 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNNQR 361 H ++RD+K +NILL G ++++D G +I PE VGT +MAPEV+ + Sbjct: 134 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 193 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPF 385 YG D W LG + EMIEG+ P+ Sbjct: 194 YGPKVDIWSLGIMAIEMIEGEPPY 217 >6FDY-U nrPDB Length = 276 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 71/249 (28%), Positives = 119/249 (47%), Gaps = 9/249 (3%) Query: 192 LGKGGFGEVC-ACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 LG G + V A + T ++ A K + KK + K E++ L E +IL+ + +V L Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL-LTEIEILKGIRHPHIVQLK 77 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 D + L++ GGDL I+ E+ A + ++ L+ LH N + Sbjct: 78 DFQWDSDNIYLIMEFCAGGDLSRFIHT--RRILPEKVARVFMQQLASALQFLHERNISHL 135 Query: 311 DLKPENILLDDY--GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDY 368 DLKP+NILL H++++D G A + D G+ YMAPE++ ++Y D Sbjct: 136 DLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDL 195 Query: 369 WGLGCLIYEMIEGQSPFRGRKEKVKREEV-DRRVLETEEVYSHKFSEEAKSICKMLLTKD 427 W +G ++YE + GQ PF R E++ RV+E S + + + + LL +D Sbjct: 196 WSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELP--LRPLLSRDCRDLLQRLLERD 253 Query: 428 AKQRLGCQE 436 +R+ Q+ Sbjct: 254 PSRRISFQD 262 >3QA8-A nrPDB Length = 676 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 71/207 (34%), Positives = 105/207 (50%), Gaps = 18/207 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG GGFG V + TG+ A K+ ++ + + E L E QI++K+N VV+ Sbjct: 22 LGTGGFGYVLRWIHQDTGEQVAIKQC-RQELSPKNRERWCL-EIQIMKKLNHPNVVS--- 76 Query: 252 AYETKDAL---------CLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGLED 301 A E D L L + GGDL+ ++ N G +E ++I L Sbjct: 77 AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRY 136 Query: 302 LHRENTVYRDLKPENILLDDYGHI---RISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN 358 LH ++RDLKPENI+L +I DLG A ++ +G+L VGT+ Y+APE+L Sbjct: 137 LHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELLE 196 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPF 385 ++Y ++ DYW G L +E I G PF Sbjct: 197 QKKYTVTVDYWSFGTLAFECITGFRPF 223 >2VZ6-A nrPDB Length = 313 Score = 96.3 bits (238), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 71/272 (26%), Positives = 125/272 (45%), Gaps = 12/272 (4%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 ++ ++ + LGKG F V C G+ YA K + K++ R + + E +I + Sbjct: 21 QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE-REARICRLLK 79 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +V L + + L+ ++ GG+L I + + E A +IL + Sbjct: 80 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHC 137 Query: 303 HRENTVYRDLKPENILLDDY---GHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLN 358 H+ V+RDLKPEN+LL ++++D GLA+++ E G GT GY++PEVL Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 YG D W G ++Y ++ G PF + +++ + + EAK Sbjct: 198 KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 257 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + +LT + +R+ AAE +HP+ + Sbjct: 258 LINKMLTINPSKRI-----TAAEALKHPWISH 284 >3KN6-A nrPDB Length = 325 Score = 95.9 bits (237), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 72/252 (28%), Positives = 121/252 (48%), Gaps = 18/252 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G F C + + + +A K + K+ + E AL ++ E +V L Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITAL---KLCE--GHPNIVKLHE 73 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 + + LV+ ++NGG+L I + F E A + +++ + +H V+RD Sbjct: 74 VFHDQLHTFLVMELLNGGELFERIKKKKH--FSETEASYIMRKLVSAVSHMHDVGVVHRD 131 Query: 312 LKPENILLDDYG---HIRISDLGLA-VKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD 367 LKPEN+L D I+I D G A +K P+ ++ T+ Y APE+LN Y S D Sbjct: 132 LKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCD 191 Query: 368 YWGLGCLIYEMIEGQSPFRGRKEKV---KREEVDRRVLETEEVYS----HKFSEEAKSIC 420 W LG ++Y M+ GQ PF+ + E+ +++ + + + S+EAK + Sbjct: 192 LWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLI 251 Query: 421 KMLLTKDAKQRL 432 + LLT D +RL Sbjct: 252 QGLLTVDPNKRL 263 >5U6Y-A nrPDB Length = 461 Score = 95.5 bits (236), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 123/269 (45%), Gaps = 12/269 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++ + LGKG F V C G+ YA K + K++ R + + E +I + Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE-REARICRLLKHPN 60 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 +V L + + L+ ++ GG+L I + + E A +IL + H+ Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 306 NTVYRDLKPENILLDDY---GHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQR 361 V+RDLKPEN+LL ++++D GLA+++ E G GT GY++PEVL Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 YG D W G ++Y ++ G PF + +++ + + EAK + Sbjct: 179 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 238 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 +LT + +R+ AAE +HP+ + Sbjct: 239 KMLTINPSKRI-----TAAEALKHPWISH 262 >3DB8-A nrPDB Length = 317 Score = 95.5 bits (236), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 71/259 (27%), Positives = 119/259 (45%), Gaps = 9/259 (3%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P T + + R LGKGGF + T +++A K + K + K + E I + Sbjct: 38 PRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHK 97 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEILCG 298 +++ VV +E D + +VL I L + H E A ++ + + G Sbjct: 98 SLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELH---KRRKAVTEPEARYFMRQTIQG 154 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVL 357 ++ LH ++RDLK N+ L+D ++I D GLA KI +G+ + GT Y+APEVL Sbjct: 155 VQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL 214 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 + + D W LGC++Y ++ G+ PF E +E R+ + E + A Sbjct: 215 CKKGHSFEVDIWSLGCILYTLLVGKPPF----ETSCLKETYIRIKKNEYSVPRHINPVAS 270 Query: 418 SICKMLLTKDAKQRLGCQE 436 ++ + +L D R E Sbjct: 271 ALIRRMLHADPTLRPSVAE 289 >4WNO-A nrPDB Length = 287 Score = 95.1 bits (235), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 110/219 (50%), Gaps = 14/219 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM-YACKRLEKKRIKKRKGESMALNEKQI 237 + V K F + ++G G F V + RA + A K + KK + K +++ E +I Sbjct: 13 ETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAK--SQTLLGKEIKI 70 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 L+++ + +V L E +++ LV+ NGGDL +++ M E+ + +I Sbjct: 71 LKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRT--LSEDTIRLFLQQIAG 128 Query: 298 GLEDLHRENTVYRDLKPENILLDDYG---------HIRISDLGLAVKIPEGDLIRGRVGT 348 + LH + ++RDLKP+NILL + ++I+D G A + + G+ Sbjct: 129 AMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGS 188 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 YMAPEV+ +Q Y D W +G ++Y+ + G++PF+ Sbjct: 189 PMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQA 227 >6FD3-A nrPDB Length = 300 Score = 95.1 bits (235), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 103/204 (50%), Gaps = 7/204 (3%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 K + ++ +G+G G V ATG+ A K++ ++ K++ + +NE ++ + Sbjct: 21 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENK 77 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 + +VN +Y D L +V+ + GG L + +E + E L L+ L Sbjct: 78 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALDFL 134 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNNQR 361 H ++RD+K +NILL G ++++D G +I PE VGT +MAPEV+ + Sbjct: 135 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 194 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPF 385 YG D W LG + EM+EG+ P+ Sbjct: 195 YGPKVDIWSLGIMAIEMVEGEPPY 218 >2V7O-A nrPDB Length = 336 Score = 95.1 bits (235), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 69/268 (25%), Positives = 125/268 (46%), Gaps = 12/268 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + ++ + LGKG F V C + + YA K + K++ R + + E +I + Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLE-REARICRLLKH 89 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + + LV ++ GG+L I + + E A +IL + +H Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIHQILESVNHIH 147 Query: 304 RENTVYRDLKPENILLDDY---GHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNN 359 + + V+RDLKPEN+LL ++++D GLA+++ E G GT GY++PEVL Sbjct: 148 QHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK 207 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 YG D W G ++Y ++ G PF + +++ + + EAK++ Sbjct: 208 DPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 267 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 +LT + +R+ A + +HP+ Sbjct: 268 INQMLTINPAKRI-----TADQALKHPW 290 >4D2V-A nrPDB Length = 356 Score = 94.7 bits (234), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 63/207 (30%), Positives = 109/207 (52%), Gaps = 15/207 (7%) Query: 186 FRQYRVLGKGGFGEV-CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI--LEKVN 242 + + +G GGF +V AC + TG+M A K ++K + G + + +I L+ + Sbjct: 31 YELHETIGTGGFAKVKLACHI-LTGEMVAIKIMDKNTL----GSDLPRIKTEIEALKNLR 85 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 Q + L + ET + + +VL GG+L +I + EE R +F +I+ + + Sbjct: 86 HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVF--RQIVSAVAYV 143 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---LIRGRVGTVGYMAPEVLNN 359 H + +RDLKPEN+L D+Y +++ D GL K P+G+ ++ G + Y APE++ Sbjct: 144 HSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQACCGALAYAAPELIQG 202 Query: 360 QRY-GLSPDYWGLGCLIYEMIEGQSPF 385 + Y G D W +G L+Y ++ G PF Sbjct: 203 KSYLGSEADVWSMGILLYVLMCGFLPF 229 >2OU7-A nrPDB Length = 335 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 74/249 (29%), Positives = 119/249 (47%), Gaps = 13/249 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRI-KKRKGESMALNEKQILEKVNSQFVVNLA 250 LGKGGF + T +++A K + K + K + E M++ E I + Q VV Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSM-EISIHRSLAHQHVVGFH 107 Query: 251 YAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 +E D + +VL + L + H E A +Y +I+ G + LHR ++ Sbjct: 108 GFFEDNDFVFVVLELCRRRSLLELH---KRRKALTEPEARYYLRQIVLGCQYLHRNRVIH 164 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV--GTVGYMAPEVLNNQRYGLSPD 367 RDLK N+ L++ ++I D GLA K+ E D R +V GT Y+APEVL+ + + D Sbjct: 165 RDLKLGNLFLNEDLEVKIGDFGLATKV-EYDGERKKVLCGTPNYIAPEVLSKKGHSFEVD 223 Query: 368 YWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKD 427 W +GC++Y ++ G+ PF E +E R+ + E + A S+ + +L D Sbjct: 224 VWSIGCIMYTLLVGKPPF----ETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTD 279 Query: 428 AKQRLGCQE 436 R E Sbjct: 280 PTARPTINE 288 >3DAK-A nrPDB Length = 290 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 82/288 (28%), Positives = 133/288 (46%), Gaps = 26/288 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + ++ + V+G G V A + A KR+ ++ + E L E Q + + Sbjct: 7 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDE--LLKEIQAMSQ 64 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGG---DLKFHIYNMG---NPGFEEERALFYAAE 294 + +V+ ++ KD L LV+ +++GG D+ HI G + +E E Sbjct: 65 CHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE-GDLIRGR-----VGT 348 +L GLE LH+ ++RD+K NILL + G ++I+D G++ + GD+ R + VGT Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 184 Query: 349 VGYMAPEVLNNQR-YGLSPDYWGLGCLIYEMIEGQSPFRG---RKEKVKREEVDRRVLET 404 +MAPEV+ R Y D W G E+ G +P+ K + + D LET Sbjct: 185 PCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLET 244 Query: 405 EEVYSHKFSEEAKSICKML---LTKDAKQRLGCQEEGAAEVKRHPFFR 449 + KS KM+ L KD ++R AAE+ RH FF+ Sbjct: 245 GVQDKEMLKKYGKSFRKMISLCLQKDPEKR-----PTAAELLRHKFFQ 287 >4JG6-A nrPDB Length = 355 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 81/266 (30%), Positives = 122/266 (45%), Gaps = 23/266 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G + C +AT +A K ++K K+ E + + +L ++ L Sbjct: 43 IGVGSYSVCKRCIHKATNMEFAVKIIDKS--KRDPTEEIEI----LLRYGQHPNIITLKD 96 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 Y+ + +V +M GG+L I + F E A I +E LH + V+RD Sbjct: 97 VYDDGKYVYVVTELMKGGELLDKI--LRQKFFSEREASAVLFTITKTVEYLHAQGVVHRD 154 Query: 312 LKPENIL-LDDYGH---IRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNNQRYGLSP 366 LKP NIL +D+ G+ IRI D G A ++ E L+ T ++APEVL Q Y + Sbjct: 155 LKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGYDAAC 214 Query: 367 DYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV----LETEEVYSHKFSEEAKSICKM 422 D W LG L+Y M+ G +PF + EE+ R+ Y + S+ AK + Sbjct: 215 DIWSLGVLLYTMLTGYTPFANGPDDTP-EEILARIGSGKFSLSGGYWNSVSDTAKDLVSK 273 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFF 448 +L D QRL AA V RHP+ Sbjct: 274 MLHVDPHQRL-----TAALVLRHPWI 294 >5J5T-A nrPDB Length = 370 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 87/321 (27%), Positives = 144/321 (44%), Gaps = 37/321 (11%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ F + +G G +G+V + TG++ A K IK GE A+ +++I+ Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKV-----IKLEPGEDFAVVQQEIIMMK 56 Query: 242 NSQFVVNLAY--AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + + +AY +Y +D L + + GG L+ IY++ P E + + + E L GL Sbjct: 57 DCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQ-DIYHVTGP-LSELQIAYVSRETLQGL 114 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRVGTVGYMAPEVLN 358 LH + ++RD+K NILL D GH++++D G++ +I R +GT +MAPEV Sbjct: 115 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAA 174 Query: 359 NQR---YGLSPDYWGLGCLIYEMIEGQSP----------FRGRKEKVKREEVDRRVLETE 405 +R Y D W +G E+ E Q P F K + ++ ++ Sbjct: 175 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM---- 230 Query: 406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPF 465 K+S KM LTK+ K+R A ++ +HPF + L +LD Sbjct: 231 -----KWSNSFHHFVKMALTKNPKKR-----PTAEKLLQHPFVTQHLTRSLAIELLDKVN 280 Query: 466 VPDPRAVYCKDVLDIEQFSTV 486 PD + D D E V Sbjct: 281 NPDHSTYHDFDDDDPEPLVAV 301 >4J52-A nrPDB Length = 293 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 70/243 (28%), Positives = 117/243 (48%), Gaps = 11/243 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRI-KKRKGESMALNEKQILEKVNSQFVVNLA 250 LGKGGF + T +++A K + K + K + E M++ E I + Q VV Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSM-EISIHRSLAHQHVVGFH 80 Query: 251 YAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 +E D + +VL + L + H E A +Y +I+ G + LHR ++ Sbjct: 81 GFFEDNDFVFVVLELCRRRSLLELH---KRRKALTEPEARYYLRQIVLGCQYLHRNRVIH 137 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDY 368 RDLK N+ L++ ++I D GLA K+ +G+ + GT Y+APEVL+ + + D Sbjct: 138 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDV 197 Query: 369 WGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDA 428 W +GC++Y ++ G+ PF E +E R+ + E + A S+ + +L D Sbjct: 198 WSIGCIMYTLLVGKPPF----ETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDP 253 Query: 429 KQR 431 R Sbjct: 254 TAR 256 >4APC-A nrPDB Length = 350 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 97/197 (49%), Gaps = 2/197 (1%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G FG+ + G+ Y K + R+ ++ E + E +L + +V Sbjct: 32 IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREE-SRREVAVLANMKHPNIVQYRE 90 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 ++E +L +V+ GGDL I F+E++ L + +I L+ +H ++RD Sbjct: 91 SFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRD 150 Query: 312 LKPENILLDDYGHIRISDLGLA-VKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG 370 +K +NI L G +++ D G+A V +L R +GT Y++PE+ N+ Y D W Sbjct: 151 IKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKPYNNKSDIWA 210 Query: 371 LGCLIYEMIEGQSPFRG 387 LGC++YE+ + F Sbjct: 211 LGCVLYELCTLKHAFEA 227 >3F3Z-A nrPDB Length = 277 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 75/262 (28%), Positives = 124/262 (47%), Gaps = 21/262 (8%) Query: 182 TKNTFRQYRVL----GKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI 237 TK QY L G+G +GEV + T A K++ K ++ E +I Sbjct: 3 TKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFK---QEIEI 59 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 ++ ++ ++ L +E + LV+ + GG+L + + F E A ++L Sbjct: 60 MKSLDHPNIIRLYETFEDNTDIYLVMELCTGGELFERVVH--KRVFRESDAARIMKDVLS 117 Query: 298 GLEDLHRENTVYRDLKPENIL-LDDY--GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAP 354 + H+ N +RDLKPEN L L D +++ D GLA + G ++R +VGT Y++P Sbjct: 118 AVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSP 177 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK--- 411 +VL YG D W G ++Y ++ G PF + EV ++ E + K Sbjct: 178 QVLEGL-YGPECDEWSAGVMMYVLLCGYPPFSAPTD----SEVMLKIREGTFTFPEKDWL 232 Query: 412 -FSEEAKSICKMLLTKDAKQRL 432 S +A+S+ + LLTK KQR+ Sbjct: 233 NVSPQAESLIRRLLTKSPKQRI 254 >4KRC-A nrPDB Length = 317 Score = 92.4 bits (228), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 108/217 (49%), Gaps = 11/217 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + F+Q LG G + V + TG A K E K + S A+ E +++++ Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALK--EVKLDSEEGTPSTAIREISLMKEL 60 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI--YNMGNP--GFEEERALFYAAEILC 297 + +V L T++ L LV M+ DLK ++ +GN G E ++ ++L Sbjct: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGL--AVKIPEGDLIRGRVGTVGYMAPE 355 GL H ++RDLKP+N+L++ G +++ D GL A IP + V T+ Y AP+ Sbjct: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV-NTFSSEVVTLWYRAPD 178 Query: 356 VLNNQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEK 391 VL R Y S D W GC++ EMI G+ F G ++ Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE 215 >3SOA-A nrPDB Length = 444 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 12/269 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++ + LGKG F V C G+ YA + K++ R + + E +I + Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLE-REARICRLLKHPN 71 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 +V L + + L+ ++ GG+L I + + E A +IL + H+ Sbjct: 72 IVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 306 NTVYRDLKPENILLDDY---GHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQR 361 V+R+LKPEN+LL ++++D GLA+++ E G GT GY++PEVL Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 YG D W G ++Y ++ G PF + +++ + + EAK + Sbjct: 190 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 249 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 +LT + +R+ AAE +HP+ + Sbjct: 250 KMLTINPSKRI-----TAAEALKHPWISH 273 >3IS5-A nrPDB Length = 285 Score = 91.7 bits (226), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 80/284 (28%), Positives = 129/284 (45%), Gaps = 28/284 (9%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 Q + F R LG G FG+V + R++G K + K R + + A E ++L Sbjct: 17 QGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEA--EIEVL 74 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF--YAAEIL 296 + ++ ++ + +E + +V+ GG+L I + G +AL Y AE++ Sbjct: 75 KSLDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARG----KALSEGYVAELM 130 Query: 297 ----CGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGTV 349 L H ++ V++DLKPENIL D + I+I D GLA + GT Sbjct: 131 KQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTA 190 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS 409 YMAPEV + D W G ++Y ++ G PF G EEV ++ E Y+ Sbjct: 191 LYMAPEVF-KRDVTFKCDIWSAGVVMYFLLTGCLPFTG----TSLEEVQQKATYKEPNYA 245 Query: 410 ---HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + +A + K +LTKD ++R AA+V H +F+ Sbjct: 246 VECRPLTPQAVDLLKQMLTKDPERR-----PSAAQVLHHEWFKQ 284 >6DTL-A nrPDB Length = 364 Score = 91.7 bits (226), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 96/200 (48%), Gaps = 4/200 (2%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL-- 249 +GKG +G VC+ T + A K++ K + L E ++L ++ + +V + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-TLREIKLLRHMDHENIVAIRD 96 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 ++A V D H N EE ++ +IL GL+ +H N ++ Sbjct: 97 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 156 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE-VLNNQRYGLSPDY 368 RDLKP N+LL+ ++I D GLA E D + V T Y APE +LN+ Y + D Sbjct: 157 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 216 Query: 369 WGLGCLIYEMIEGQSPFRGR 388 W +GC+ E+++ + F GR Sbjct: 217 WSVGCIFMELMDRKPLFPGR 236 >4QMW-A nrPDB Length = 310 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 99/201 (49%), Gaps = 8/201 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F + +GKG FGEV T K+ A K ++ + + + E +L + +S + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 88 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG-FEEERALFYAAEILCGLEDLHR 304 V +Y L +++ + GG ++ PG +E + EIL GL+ LH Sbjct: 89 VTKYYGSYLKDTKLWIIMEYLGGGS----ALDLLEPGPLDETQIATILREILKGLDYLHS 144 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR-VGTVGYMAPEVLNNQRYG 363 E ++RD+K N+LL ++G ++++D G+A ++ + + R VGT +MAPEV+ Y Sbjct: 145 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD 204 Query: 364 LSPDYWGLGCLIYEMIEGQSP 384 D W LG E+ G+ P Sbjct: 205 SKADIWSLGITAIELARGEPP 225 >2BPM-A nrPDB Length = 309 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 38/301 (12%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V F++ +G+G +G V + + TG++ A K++ + + S A+ E +L++ Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKE 62 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 +N +V L T++ L LV ++ DLK + G Y ++L GL Sbjct: 63 LNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG---RVGTVGYMAPEVL 357 H ++RDLKP+N+L++ G I+++D GLA G +R V T+ Y APE+L Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEIL 179 Query: 358 NN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV--------- 407 + Y + D W LGC+ EM+ ++ F G E + + R + +EV Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 239 Query: 408 -YSHKF---------------SEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 Y F E+ +S+ +L D +R+ + A HPFF+++ Sbjct: 240 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA-----HPFFQDV 294 Query: 452 N 452 Sbjct: 295 T 295 >4BBM-A nrPDB Length = 331 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 106/203 (52%), Gaps = 13/203 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRL----EKKRIKKRKGESMALNEKQILEKVNSQFV 246 ++G+G +G V C+ + TG++ A K+ + K +KK +A+ E ++L+++ + + Sbjct: 32 LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKK-----IAMREIKLLKQLRHENL 86 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 VNL + K LV ++ L + G + + Y +I+ G+ H N Sbjct: 87 VNLLEVCKKKKRWYLVFEFVDHTILD--DLELFPNGLDYQVVQKYLFQIINGIGFCHSHN 144 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPE-GDLIRGRVGTVGYMAPEVL-NNQRYGL 364 ++RD+KPENIL+ G +++ D G A + G++ V T Y APE+L + +YG Sbjct: 145 IIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGK 204 Query: 365 SPDYWGLGCLIYEMIEGQSPFRG 387 + D W +GCL+ EM G+ F G Sbjct: 205 AVDVWAIGCLVTEMFMGEPLFPG 227 >4BGQ-A nrPDB Length = 304 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 104/209 (49%), Gaps = 5/209 (2%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 N F V+G+G +G V C+ + T ++ A K+ + + E+ L E ++L + Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKET-TLRELKMLRTLKQ 70 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + +V L A+ + L LV + L+ + M N G E+ Y +++ + H Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLEL-LEEMPN-GVPPEKVKSYIYQLIKAIHWCH 128 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR--GRVGTVGYMAPEVLNNQR 361 + + V+RD+KPEN+L+ +++ D G A + EG+ V T Y +PE+L Sbjct: 129 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAP 188 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390 YG S D W +GC++ E+ +GQ F G E Sbjct: 189 YGKSVDMWSVGCILGELSDGQPLFPGESE 217 >1CM8-A nrPDB Length = 367 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 88/315 (27%), Positives = 140/315 (44%), Gaps = 52/315 (16%) Query: 178 RQPVTKN------TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231 RQ VTK +R + +G G +G VC+ TG A K+L + + A Sbjct: 13 RQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRA 71 Query: 232 LNEKQILEKVNSQFVVNLAYAY---ETKDALC---LVLTIMNGGDLKFHIYNMGNPGFEE 285 E ++L+ + + V+ L + ET D LV+ M G DL M + E Sbjct: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG---KLMKHEKLGE 127 Query: 286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR 345 +R F ++L GL +H ++RDLKP N+ +++ ++I D GLA + + G Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGY 185 Query: 346 VGTVGYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 V T Y APEV LN RY + D W +GC++ EMI G++ F+G + +E+ + Sbjct: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 Query: 405 EEVYSHKF-SEEAKSICKML--------------------------LTKDAKQRLGCQEE 437 + + S+EAK+ K L L DA+QR+ Sbjct: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV----- 300 Query: 438 GAAEVKRHPFFRNMN 452 A E HP+F +++ Sbjct: 301 TAGEALAHPYFESLH 315 >5WAX-A nrPDB Length = 310 Score = 89.7 bits (221), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 74/279 (26%), Positives = 119/279 (42%), Gaps = 22/279 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R +G G FG + RA G++ A K +E+ + +N + + ++ Sbjct: 17 RDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSL----RHPNIIRF 72 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 T L +V+ +GG+L I N G F E+ A F+ +++ G+ H + Sbjct: 73 KEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHSMQVCH 130 Query: 310 RDLKPENILLD--DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSP 366 RDLK EN LLD ++I D G + + VGT Y+APEVL + Y G Sbjct: 131 RDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVA 190 Query: 367 DYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV---YSHKFSEEAKSICKML 423 D W G +Y M+ G PF E + +R+L + Y H S E + + + Sbjct: 191 DVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVH-ISPECQDLISRI 249 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLD 462 + R+ E++ HP+F K L A ++D Sbjct: 250 FVANPATRITI-----PEIRNHPWF----LKNLPADLMD 279 >3COM-A nrPDB Length = 314 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 75/279 (26%), Positives = 122/279 (43%), Gaps = 21/279 (7%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 L +QP + F LG+G +G V + TG++ A K++ + + + E Sbjct: 23 LTKQP--EEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE-----IIKEI 75 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 I+++ +S VV +Y L +V+ G + I + N E+ Sbjct: 76 SIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVS-DIIRLRNKTLTEDEIATILQST 134 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV-GTVGYMAP 354 L GLE LH ++RD+K NILL+ GH +++D G+A ++ + R V GT +MAP Sbjct: 135 LKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAP 194 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR---VLETEEVYSHK 411 EV+ Y D W LG EM EG+ P+ + E++S Sbjct: 195 EVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDN 254 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 F++ K L K +QR A ++ +HPF R+ Sbjct: 255 FTD----FVKQCLVKSPEQR-----ATATQLLQHPFVRS 284 >6QAU-A nrPDB Length = 280 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 102/208 (49%), Gaps = 16/208 (7%) Query: 191 VLGKGGFGEVCACQVRA-TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 ++G G F V + R T A K + KK + K + + E +IL+++ + +V L Sbjct: 18 LVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSK--SQILLGKEIKILKELQHENIVAL 75 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 E +++ LV+ NGGDL ++ G E+ + +I + LH + ++ Sbjct: 76 YDVQELPNSVFLVMEYCNGGDLADYLQAKGT--LSEDTIRVFLHQIAAAMRILHSKGIIH 133 Query: 310 RDLKPENILLDDYGH----------IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 RDLKP+NILL Y + I+I+D G A + + G+ YMAPEV+ + Sbjct: 134 RDLKPQNILLS-YANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMS 192 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 Q Y D W +G +IY+ + G+ PF+ Sbjct: 193 QHYDAKADLWSIGTVIYQCLVGKPPFQA 220 >2XIK-A nrPDB Length = 294 Score = 89.4 bits (220), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 98/201 (48%), Gaps = 8/201 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F + +GKG FGEV T ++ A K ++ + + + E +L + +S + Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 78 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG-FEEERALFYAAEILCGLEDLHR 304 + +Y L +++ + GG ++ PG EE EIL GL+ LH Sbjct: 79 ITRYFGSYLKSTKLWIIMEYLGGGS----ALDLLKPGPLEETYIATILREILKGLDYLHS 134 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR-VGTVGYMAPEVLNNQRYG 363 E ++RD+K N+LL + G ++++D G+A ++ + + R VGT +MAPEV+ Y Sbjct: 135 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD 194 Query: 364 LSPDYWGLGCLIYEMIEGQSP 384 D W LG E+ +G+ P Sbjct: 195 FKADIWSLGITAIELAKGEPP 215 >6CCF-A nrPDB Length = 290 Score = 89.0 bits (219), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 71/228 (31%), Positives = 113/228 (49%), Gaps = 32/228 (14%) Query: 234 EKQILEKVNSQFVVNLAYAYE--TKDALCLVLTIMNGGDLKFHIYNMGNP---GFEEERA 288 E IL+K++ VV L + +D L LV ++ G + M P F EE+A Sbjct: 78 EIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPV------MEVPCDKPFSEEQA 131 Query: 289 LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-IRGRVG 347 Y +++ GLE LH + V+RD+KP N+LL D GH++I+D G++ + D + G Sbjct: 132 RLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG 191 Query: 348 TVGYMAPEVLNN--QRY-GLSPDYWGLGCLIYEMIEGQSPF-----RGRKEKVKREEVDR 399 T +MAPE +++ Q + G + D W G +Y + G+ PF K+K E V Sbjct: 192 TPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPV-- 249 Query: 400 RVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 V E + SEE K + +L K+ + R+G ++K HP+ Sbjct: 250 -VFPEEP----EISEELKDLILKMLDKNPETRIGV-----PDIKLHPW 287 >1TKI-A nrPDB Length = 321 Score = 88.6 bits (218), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 72/274 (26%), Positives = 122/274 (44%), Gaps = 19/274 (6%) Query: 183 KNTFRQYRV---LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI-- 237 K + +Y + LG+G FG V C ++ K Y K + K KG L +K+I Sbjct: 1 KELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFV------KVKGTDQVLVKKEISI 54 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 L + +++L ++E+ + L ++ ++G D+ F N E + Y ++ Sbjct: 55 LNIARHRNILHLHESFESMEELVMIFEFISGLDI-FERINTSAFELNEREIVSYVHQVCE 113 Query: 298 GLEDLHRENTVYRDLKPENILLDD--YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 L+ LH N + D++PENI+ I+I + G A ++ GD R Y APE Sbjct: 114 ALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPE 173 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 V + + D W LG L+Y ++ G +PF + E + +E + S E Sbjct: 174 VHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIE 233 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 A LL K+ K R+ A+E +HP+ + Sbjct: 234 AMDFVDRLLVKERKSRM-----TASEALQHPWLK 262 >4AF3-A nrPDB Length = 292 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/270 (27%), Positives = 125/270 (46%), Gaps = 16/270 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 T + F R LGKG FG V + + + + A K L K +I+K E E +I + Sbjct: 21 TIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL 80 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + ++ L + + + L+L G+L + F+E+R E+ L Sbjct: 81 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCT--FDEQRTATIMEELADALMY 138 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV--GTVGYMAPEVLNN 359 H + ++RD+KPEN+LL G ++I+D G +V P +R + GT+ Y+ PE++ Sbjct: 139 CHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPS---LRRKTMCGTLDYLPPEMIEG 195 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 + + D W +G L YE++ G PF E E RR+++ + + A+ + Sbjct: 196 RMHNEKVDLWCIGVLCYELLVGNPPF----ESASHNETYRRIVKVDLKFPASVPTGAQDL 251 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 LL + +RL A+V HP+ R Sbjct: 252 ISKLLRHNPSERLPL-----AQVSAHPWVR 276 >3FXW-A nrPDB Length = 336 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 72/263 (27%), Positives = 121/263 (46%), Gaps = 19/263 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 VT + +VLG G G+V C R TG+ A K L +++ + + Sbjct: 26 VTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHH-------WQA 78 Query: 241 VNSQFVVNLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +V + YE K L +++ M GG+L I G+ F E A +I Sbjct: 79 SGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIG 138 Query: 297 CGLEDLHRENTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMA 353 ++ LH N +RD+KPEN+L + ++++D G A + + L + T Y+A Sbjct: 139 TAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL-QTPCYTPYYVA 197 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH--- 410 PEVL ++Y S D W LG ++Y ++ G PF + + RR+ + + + Sbjct: 198 PEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEW 257 Query: 411 -KFSEEAKSICKMLLTKDAKQRL 432 + SE+AK + ++LL D +RL Sbjct: 258 SEVSEDAKQLIRLLLKTDPTERL 280 >4LG4-A nrPDB Length = 299 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/279 (26%), Positives = 124/279 (44%), Gaps = 21/279 (7%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 L +QP + F LG+G +G V + +G++ A K++ + + + E Sbjct: 5 LTKQP--EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE-----IIKEI 57 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 I+++ +S +VV +Y L +V+ G + I + N E+ Sbjct: 58 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVS-DIIRLRNKTLIEDEIATILKST 116 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV-GTVGYMAP 354 L GLE LH ++R++K NILL+ GH +++D G+A ++ + R V GT +MAP Sbjct: 117 LKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAP 176 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR---VLETEEVYSHK 411 EV+ Y D W LG EM EG+ P+ + E++S Sbjct: 177 EVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDD 236 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 F++ K L K+ +QR A ++ +HPF +N Sbjct: 237 FTD----FVKKCLVKNPEQR-----ATATQLLQHPFIKN 266 >5G6V-A nrPDB Length = 324 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 81/291 (27%), Positives = 133/291 (45%), Gaps = 29/291 (9%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGES-MALNEKQILEKVNS 243 T+ + LG+G + V + + T + A K + R++ +G A+ E +L+ + Sbjct: 3 TYIKLDKLGEGTYATVYKGKSKLTDNLVALKEI---RLEHEEGAPCTAIREVSLLKDLKH 59 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L T+ +L LV ++ DLK ++ + GN LF ++L GL H Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLF-QLLRGLAYCH 117 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLA-VKIPEGDLIRGRVGTVGYMAPEV-LNNQR 361 R+ ++RDLKP+N+L+++ G ++++D GLA K V T+ Y P++ L + Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTD 177 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRG-----------RKEKVKREEVDRRVLETEEVYSH 410 Y D WG+GC+ YEM G+ F G R EE +L EE ++ Sbjct: 178 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 237 Query: 411 ---KFSEEAKSICKMLLTKDAKQRLG--CQEEG-----AAEVKRHPFFRNM 451 K+ EA L D L Q EG A + +HPFF ++ Sbjct: 238 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSL 288 >3NIZ-A nrPDB Length = 311 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 73/297 (24%), Positives = 141/297 (47%), Gaps = 41/297 (13%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 +++ +G+G +G V + + G++ A KR+ + + S A+ E +L++++ Sbjct: 23 YQKLEKVGEGTYGVVYKAK-DSQGRIVALKRI-RLDAEDEGIPSTAIREISLLKELHHPN 80 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 +V+L ++ L LV M DLK + + G ++ + Y ++L G+ H+ Sbjct: 81 IVSLIDVIHSERCLTLVFEFMEK-DLK-KVLDENKTGLQDSQIKIYLYQLLRGVAHCHQH 138 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG---RVGTVGYMAPEVL-NNQR 361 ++RDLKP+N+L++ G ++++D GLA G +R V T+ Y AP+VL +++ Sbjct: 139 RILHRDLKPQNLLINSDGALKLADFGLARAF--GIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGR------------------KEKVKREEVDRRVLE 403 Y S D W +GC+ EMI G+ F G +E + +E+ Sbjct: 197 YSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR 256 Query: 404 TEEVYSHK--------FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 T +V+ K F +E + +L D +R+ A + HP+F++++ Sbjct: 257 TFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRI-----SARDAMNHPYFKDLD 308 >6AO5-A nrPDB Length = 362 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 73/279 (26%), Positives = 122/279 (43%), Gaps = 21/279 (7%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 L +QP + F LG+G +G V + +G++ A K+ + + E Sbjct: 4 LTKQP--EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQ-----VPVESDLQEIIKEI 56 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 I+++ +S +VV +Y L +V+ G + I + N E+ Sbjct: 57 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVS-DIIRLRNKTLIEDEIATILKST 115 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV-GTVGYMAP 354 L GLE LH ++R++K NILL+ GH +++D G+A ++ + R V GT +MAP Sbjct: 116 LKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAP 175 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR---VLETEEVYSHK 411 EV+ Y D W LG EM EG+ P+ + E++S Sbjct: 176 EVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDD 235 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 F++ K L K+ +QR A ++ +HPF +N Sbjct: 236 FTD----FVKKCLVKNPEQR-----ATATQLLQHPFIKN 265 >3E7O-A nrPDB Length = 360 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 102/208 (49%), Gaps = 12/208 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++Q + +G G G VCA G A K+L + + + A E +L+ VN + Sbjct: 24 YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP-FQNQTHAKRAYRELVLLKCVNHKN 82 Query: 246 VVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +++L + + L LV+ +M+ ++ + + + ER + ++LCG+ Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIHMELDHERMSYLLYQMLCGI 137 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 + LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 138 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILG 197 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 Y + D W +GC++ E+++G F+G Sbjct: 198 MGYKENVDIWSVGCIMGELVKGSVIFQG 225 >2HW6-A nrPDB Length = 307 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 82/295 (27%), Positives = 126/295 (42%), Gaps = 48/295 (16%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN-SQFVVNL 249 +LG+G + +V GK YA K +EK+ R S E + L + ++ ++ L Sbjct: 20 LLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR---SRVFREVETLYQCQGNKNILEL 76 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 +E LV + GG + HI + F E A ++ L+ LH + + Sbjct: 77 IEFFEDDTRFYLVFEKLQGGSILAHIQKQKH--FNEREASRVVRDVAAALDFLHTKGIAH 134 Query: 310 RDLKPENILLDD---YGHIRISDLGLA-----------VKIPEGDLIRGRVGTVGYMAPE 355 RDLKPENIL + ++I D L + PE + G+ YMAPE Sbjct: 135 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPE---LTTPCGSAEYMAPE 191 Query: 356 VL-----NNQRYGLSPDYWGLGCLIYEMIEGQSPF-----------RGRKEKVKREEVDR 399 V+ Y D W LG ++Y M+ G PF RG +V + ++ Sbjct: 192 VVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFE 251 Query: 400 RVLETEEVYSHK----FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + E + + K S EAK + LL +DAKQRL AA+V +HP+ + Sbjct: 252 SIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQG 301 >3GC9-A nrPDB Length = 370 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 122/251 (48%), Gaps = 33/251 (13%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEK---KRIKKRKGESMALNEKQILEKVNSQFV 246 R +G G +G VC+ + A K+L + I R+ E ++L+ + + V Sbjct: 34 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR----TYRELRLLKHLKHENV 89 Query: 247 VNL------AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + L A + E + LV T+M G DL + + +E F ++L GL+ Sbjct: 90 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV---KSQALSDEHVQFLVYQLLRGLK 145 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV-LNN 359 +H ++RDLKP N+ +++ +RI D GLA + E + G V T Y APE+ LN Sbjct: 146 YIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNW 203 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD--RRVLE-----TEEVYSHKF 412 Y + D W +GC++ E+++G++ F G + +D +R++E + EV + Sbjct: 204 MHYNQTVDIWSVGCIMAELLQGKALFPG------SDYIDQLKRIMEVVGTPSPEVLAKIS 257 Query: 413 SEEAKSICKML 423 SE A++ + L Sbjct: 258 SEHARTYIQSL 268 >4FZF-B nrPDB Length = 283 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 56/200 (28%), Positives = 97/200 (48%), Gaps = 6/200 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F + +GKG FGEV T ++ A K ++ + + + E +L + +S + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSY 67 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 V +Y L +++ + GG + G F+E + EIL GL+ LH E Sbjct: 68 VTKYYGSYLKGSKLWIIMEYLGGGS-ALDLLRAGP--FDEFQIATMLKEILKGLDYLHSE 124 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR-VGTVGYMAPEVLNNQRYGL 364 ++RD+K N+LL + G ++++ G+A ++ + + R VGT +MAPEV+ Y Sbjct: 125 KKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 184 Query: 365 SPDYWGLGCLIYEMIEGQSP 384 D W LG E+ +G+ P Sbjct: 185 KADIWSLGITAIELAKGEPP 204 >6CKI-A nrPDB Length = 316 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 86/295 (29%), Positives = 125/295 (42%), Gaps = 42/295 (14%) Query: 188 QYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS-QFV 246 Q VLG+G V C T + YA K +EK+ R S E ++L + + V Sbjct: 17 QEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIR---SRVFREVEMLYQCQGHRNV 73 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 + L +E +D LV M GG + HI+ + F E A ++ L+ LH + Sbjct: 74 LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH--FNELEASVVVQDVASALDFLHNKG 131 Query: 307 TVYRDLKPENILL---DDYGHIRISDLGLAVKIP-EGDL-------IRGRVGTVGYMAPE 355 +RDLKPENIL + ++I D GL I GD + G+ YMAPE Sbjct: 132 IAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPE 191 Query: 356 VL-----NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR---------------KEKVKRE 395 V+ Y D W LG ++Y ++ G PF GR + + E Sbjct: 192 VVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFE 251 Query: 396 EVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + E + S AK + LL +DAKQRL AA+V +HP+ + Sbjct: 252 SIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQG 301 >4AGU-A nrPDB Length = 311 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 128/293 (43%), Gaps = 45/293 (15%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRL----EKKRIKKRKGESMALNEKQILEKVNSQFVV 247 +G+G +G V C+ R TG++ A K+ + IKK +AL E ++L+++ +V Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKK-----IALREIRMLKQLKHPNLV 65 Query: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENT 307 NL + K L LV + L H + G E + L + H+ N Sbjct: 66 NLLEVFRRKRRLHLVFEYCDHTVL--HELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNC 123 Query: 308 VYRDLKPENILLDDYGHIRISDLGLA-VKIPEGDLIRGRVGTVGYMAPEVL-NNQRYGLS 365 ++RD+KPENIL+ + I++ D G A + D V T Y +PE+L + +YG Sbjct: 124 IHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYGPP 183 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKE--------KVKREEVDR--RVLETEEVYS------ 409 D W +GC+ E++ G + G+ + K + + R +V T + +S Sbjct: 184 VDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPD 243 Query: 410 -----------HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 S A + K L D +RL C+ ++ HP+F N+ Sbjct: 244 PEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCE-----QLLHHPYFENI 291 >3UC3-A nrPDB Length = 361 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/278 (26%), Positives = 118/278 (42%), Gaps = 24/278 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G FG + + T ++ A K +E+ + +N + L N +V Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRS-LRHPN---IVRFKE 83 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 T L +++ +GG+L I N G F E+ A F+ ++L G+ H +RD Sbjct: 84 VILTPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYCHSMQICHRD 141 Query: 312 LKPENILLDD--YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDY 368 LK EN LLD ++I D G + + VGT Y+APEVL Q Y G D Sbjct: 142 LKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADV 201 Query: 369 WGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS----HKFSEEAKSICKMLL 424 W G +Y M+ G PF +E + +R+L + YS + S E + + Sbjct: 202 WSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK--YSIPDDIRISPECCHLISRIF 259 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLD 462 D R+ E+K H +F K L A +++ Sbjct: 260 VADPATRISI-----PEIKTHSWF----LKNLPADLMN 288 >5D7A-A nrPDB Length = 308 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/286 (25%), Positives = 124/286 (43%), Gaps = 40/286 (13%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRL-----EKKRIKKRKGESMALNEKQILEK 240 F ++G G +G+V + TG++ A K + E++ IK+ E +L+K Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQ---------EINMLKK 69 Query: 241 VNSQFVVNLAYAYETK-------DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 + + Y K D L LV+ G + I N +EE + Sbjct: 70 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 129 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR----VGTV 349 EIL GL LH+ ++RD+K +N+LL + +++ D G++ ++ D GR +GT Sbjct: 130 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL---DRTVGRRNTFIGTP 186 Query: 350 GYMAPEVLN-----NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 +MAPEV+ + Y D W LG EM EG P + R Sbjct: 187 YWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PA 244 Query: 405 EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + S K+S++ +S + L K+ QR + ++ +HPF R+ Sbjct: 245 PRLKSKKWSKKFQSFIESCLVKNHSQRPATE-----QLMKHPFIRD 285 >3UDB-A nrPDB Length = 317 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 32/282 (11%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF-----V 246 +G G FG + + ++ A K +E+ GE + N K+ E +N + + Sbjct: 27 IGAGNFGVARLMRDKQANELVAVKYIER-------GEKIDENVKR--EIINHRSLRHPNI 77 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 V T L +V+ +GG+L I N G F E+ A F+ +++ G+ H Sbjct: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYAHAMQ 135 Query: 307 TVYRDLKPENILLDD--YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-G 363 +RDLK EN LLD ++I+D G + + VGT Y+APEVL + Y G Sbjct: 136 VAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYDG 195 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV---YSHKFSEEAKSIC 420 D W G +Y M+ G PF +E + R+L + Y H S E + + Sbjct: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH-ISPECRHLI 254 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLD 462 + D +R+ E++ H +F K L A +++ Sbjct: 255 SRIFVADPAKRISI-----PEIRNHEWF----LKNLPADLMN 287 >6E2O-A nrPDB Length = 295 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/201 (30%), Positives = 104/201 (51%), Gaps = 10/201 (4%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK-VNSQFVVNL 249 VLGKG +G V A + + A K + ++ + S L+E+ L K + + +V Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRY----SQPLHEEIALHKHLKHKNIVQY 84 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERAL-FYAAEILCGLEDLHRENTV 308 ++ + + + + GG L + + P + E+ + FY +IL GL+ LH V Sbjct: 85 LGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIV 144 Query: 309 YRDLKPENILLDDY-GHIRISDLGLAVKIPE-GDLIRGRVGTVGYMAPEVLNN--QRYGL 364 +RD+K +N+L++ Y G ++ISD G + ++ GT+ YMAPE+++ + YG Sbjct: 145 HRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGK 204 Query: 365 SPDYWGLGCLIYEMIEGQSPF 385 + D W LGC I EM G+ PF Sbjct: 205 AADIWSLGCTIIEMATGKPPF 225 >1G3N-A nrPDB Length = 326 Score = 82.4 bits (202), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 92/206 (44%), Gaps = 7/206 (3%) Query: 192 LGKGGFGEVC-ACQVRATGKMYACKRL-----EKKRIKKRKGESMALNEKQILEKVNSQF 245 +G+G +G+V A ++ G+ A KR+ E+ E L + E N Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 Query: 246 VVNLAYAYETKDALCLVLTIMN-GGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 + ++ T L L + DL ++ + PG E ++L GL+ LH Sbjct: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHS 138 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 V+RDLKP+NIL+ G I+++D GLA + V T+ Y APEVL Y Sbjct: 139 HRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYAT 198 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKE 390 D W +GC+ EM + FRG + Sbjct: 199 PVDLWSVGCIFAEMFRRKPLFRGSSD 224 >1S9I-A nrPDB Length = 354 Score = 82.0 bits (201), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 63/231 (27%), Positives = 106/231 (45%), Gaps = 6/231 (2%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + F + LG G G V Q R +G + A K + + K + + E Q+L + NS Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE--IKPAIRNQIIRELQVLHECNS 73 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++V A+ + + + + M+GG L + EE + +L GL L Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKR--IPEEILGKVSIAVLRGLAYLR 131 Query: 304 RENTV-YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 ++ + +RD+KP NIL++ G I++ D G++ ++ + + VGT YMAPE L Y Sbjct: 132 EKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMAPERLQGTHY 190 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 + D W +G + E+ G+ P K R V++ EE H S Sbjct: 191 SVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSIS 241 >1V0B-A nrPDB Length = 288 Score = 81.6 bits (200), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 65/204 (31%), Positives = 103/204 (50%), Gaps = 12/204 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACK--RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 +G+G +G V Q G+ +A K RLEK+ S + E IL+++ +V L Sbjct: 10 IGEGTYGVVYKAQ-NNYGETFALKKIRLEKE---DEGIPSTTIREISILKELKHSNIVKL 65 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 TK L LV ++ DLK + ++ G E A + ++L G+ H ++ Sbjct: 66 YDVIHTKKRLVLVFEHLDQ-DLK-KLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLH 123 Query: 310 RDLKPENILLDDYGHIRISDLGL--AVKIPEGDLIRGRVGTVGYMAPEVL-NNQRYGLSP 366 RDLKP+N+L++ G ++I+D GL A IP V T+ Y AP+VL +++Y + Sbjct: 124 RDLKPQNLLINREGELKIADFGLARAFGIPVRKYTH-EVVTLWYRAPDVLMGSKKYSTTI 182 Query: 367 DYWGLGCLIYEMIEGQSPFRGRKE 390 D W +GC+ EM+ G F G E Sbjct: 183 DIWSVGCIFAEMVNGAPLFPGVSE 206 >6HXF-B nrPDB Length = 302 Score = 81.6 bits (200), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 72/270 (26%), Positives = 124/270 (45%), Gaps = 22/270 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG G FG+V + + TG + A K +E K ++ + + E +IL + ++V L Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELED---YIVEIEILATCDHPYIVKLLG 83 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 AY L +++ GG + + + + G E + ++L L LH + ++RD Sbjct: 84 AYYHDGKLWIMIEFCPGGAVDAIMLEL-DRGLTEPQIQVVCRQMLEALNFLHSKRIIHRD 142 Query: 312 LKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR-VGTVGYMAPEV-----LNNQRYGLS 365 LK N+L+ G IR++D G++ K + R +GT +MAPEV + + Y Sbjct: 143 LKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYK 202 Query: 366 PDYWGLGCLIYEMIEGQSP---FRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKM 422 D W LG + EM + + P + +K + D L T K+S E + K+ Sbjct: 203 ADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLT----PSKWSVEFRDFLKI 258 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 L K+ + R AA++ HPF ++ Sbjct: 259 ALDKNPETR-----PSAAQLLEHPFVSSIT 283 >5EFQ-A nrPDB Length = 347 Score = 81.6 bits (200), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 110/222 (49%), Gaps = 16/222 (7%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 ++G+G +G+V + + TG+M A K++ +K A+ E +IL ++ Q ++N+ Sbjct: 18 IIGEGTYGQVYKARDKDTGEMVALKKVRLDN-EKEGFPITAIREIKILRQLTHQSIINMK 76 Query: 251 YAYETKD----------ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 K+ A LV M+ DL + G F E + +++ GL+ Sbjct: 77 EIVTDKEDALDFKKDKGAFYLVFEYMDH-DL-MGLLESGLVHFNENHIKSFMRQLMEGLD 134 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLA--VKIPEGDLIRGRVGTVGYMAPE-VL 357 H++N ++RD+K NILL++ G I+++D GLA E +V T+ Y PE +L Sbjct: 135 YCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLL 194 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 +RY + D W GC++ E+ + F+ +E + E + R Sbjct: 195 GEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISR 236 >1JNK-A nrPDB Length = 423 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 99/209 (47%), Gaps = 12/209 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++ + +G G G VCA + A K+L + + + A E +++ VN + Sbjct: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHKN 122 Query: 246 VVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +++L + + L LV+ +M+ ++ + + ER + ++LCG+ Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 177 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 + LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 Y + D W +GC++ EM+ + F GR Sbjct: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGR 266 >3OHT-A nrPDB Length = 389 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 103/214 (48%), Gaps = 12/214 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G +G VC+ +G A K+L + + E ++L+ + + V+ L Sbjct: 59 VGSGAYGSVCSSYDVKSGLKIAVKKLSRP-FQSIIHAKRTYRELRLLKHMKHENVIGLLD 117 Query: 252 AYETKDAL-----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 + +L ++T + G DL + ++ F +IL GL+ +H + Sbjct: 118 VFTPATSLEEFNDVYLVTHLMGADLNNIV---KCQKLTDDHVQFLIYQILRGLKYIHSAD 174 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV-LNNQRYGLS 365 ++RDLKP N+ +++ ++I D GLA D + G V T Y APE+ LN Y ++ Sbjct: 175 IIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWMHYNMT 232 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 D W +GC++ E++ G++ F G + +++ R Sbjct: 233 VDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMR 266 >5AWM-A nrPDB Length = 394 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 97/204 (47%), Gaps = 12/204 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R +G G G VCA T + A K+L + + A E ++++ VN + ++ L Sbjct: 50 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNHKNIIGL 108 Query: 250 AYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 A+ + L LV+ +M+ ++ + + +R + ++LCG++ LH Sbjct: 109 LNAFTPQRNLEEFQDVYLVMELMDA-----NLCQVIQMDLDHDRMSYLLYQMLCGIKHLH 163 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Y Sbjct: 164 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 223 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRG 387 + D W +GC++ EMI G F G Sbjct: 224 ENVDIWSVGCIMGEMIRGGVLFPG 247 >4MYG-A nrPDB Length = 372 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 105/204 (51%), Gaps = 15/204 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G +G VC+ + +G+ A K+L + + A E +L+ + + V+ L Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP-FQSEIFAKRAYRELLLLKHMQHENVIGLLD 109 Query: 252 AYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 + +L LV+ M DL+ I M F EE+ + ++L GL+ +H Sbjct: 110 VFTPASSLRNFYDFYLVMPFMQT-DLQ-KIMGME---FSEEKIQYLVYQMLKGLKYIHSA 164 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV-LNNQRYGL 364 V+RDLKP N+ +++ ++I D GLA + + ++ G V T Y APEV L+ Y Sbjct: 165 GVVHRDLKPGNLAVNEDCELKILDFGLA-RHADAEMT-GYVVTRWYRAPEVILSWMHYNQ 222 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGR 388 + D W +GC++ EM+ G++ F+G+ Sbjct: 223 TVDIWSVGCIMAEMLTGKTLFKGK 246 >6J5U-C nrPDB Length = 426 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 83/289 (28%), Positives = 124/289 (42%), Gaps = 44/289 (15%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRAT---------GKMYACKRLEKKRIKKRKG 227 E + TKN FRQ +LG+GGFG V + T G + A K+L+ + + K Sbjct: 78 ELKNATKN-FRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKE 136 Query: 228 ESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEER 287 +N L N V+ + Y E ++ L LV M G L+ H++ G Sbjct: 137 WLTEVNYLGQLSHPN--LVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAI 193 Query: 288 ALFYAAEILCGLEDLH--RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---LI 342 + A GL LH + +YRD K NILLD + ++SD GLA P GD + Sbjct: 194 RMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVS 253 Query: 343 RGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQ------------------SP 384 +GT GY APE + R D + G ++ E+I G+ +P Sbjct: 254 TKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATP 313 Query: 385 FRGRKEKVKREEVDRRVLETE--EVYSHKFSEEAKSICKMLLTKDAKQR 431 + G K K+ R+++T+ Y K + A ++ L DAK R Sbjct: 314 YLGDKRKL------FRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLR 356 >3FI2-A nrPDB Length = 353 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 99/209 (47%), Gaps = 12/209 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++ + +G G G VCA + A K+L + + + A E +++ VN + Sbjct: 26 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHKN 84 Query: 246 VVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +++L + + L LV+ +M+ ++ + + ER + ++LCG+ Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 139 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 + LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 140 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 199 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 Y + D W +GC++ EM+ + F GR Sbjct: 200 MGYKENVDIWSVGCIMGEMVRHKILFPGR 228 >5TUR-A nrPDB Length = 404 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 79/281 (28%), Positives = 126/281 (44%), Gaps = 41/281 (14%) Query: 188 QYRV---LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR----KGESMALNEKQILEK 240 QY+V LG GGFG V + + A K +EK RI G + + E +L+K Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLKK 186 Query: 241 VNSQF--VVNLAYAYETKDALCLVLTIMNG-GDLKFHIYNMGNPGFEEERALFYAAEILC 297 V+S F V+ L +E D+ L+L DL I G +EE A + ++L Sbjct: 187 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLE 244 Query: 298 GLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRV-----GTVGY 351 + H ++RD+K ENIL+D + G +++ D G G L++ V GT Y Sbjct: 245 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG------SGALLKDTVYTDFDGTRVY 298 Query: 352 MAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 PE + RY G S W LG L+Y+M+ G PF E D ++ + + Sbjct: 299 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----------EHDEEIIRGQVFFRQ 348 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 + S E + + + L R + E++ HP+ +++ Sbjct: 349 RVSSECQHLIRWCLALRPSDRPTFE-----EIQNHPWMQDV 384 >5VD3-A nrPDB Length = 311 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/266 (29%), Positives = 115/266 (43%), Gaps = 12/266 (4%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + +F++ LG G +GEV + + G++YA KR + K + L E EKV Sbjct: 56 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-SMSPFRGPKDRARKLAEVGSHEKVG 114 Query: 243 SQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 V L A+E L L T + G L+ H G E + Y + L L Sbjct: 115 QHPCCVRLEQAWEEGGILYLQ-TELCGPSLQQHCEAWGA-SLPEAQVWGYLRDTLLALAH 172 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 LH + V+ D+KP NI L G ++ D GL V++ + G YMAPE+L Sbjct: 173 LHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS- 231 Query: 362 YGLSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 YG + D + LG I E+ + P G + R+ L E ++ S E +S+ Sbjct: 232 YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQG----YLPPE--FTAGLSSELRSVL 285 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHP 446 M+L D K R + A V R P Sbjct: 286 VMMLEPDPKLRATAEALLALPVLRQP 311 >5Y86-A nrPDB Length = 588 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 96/203 (47%), Gaps = 3/203 (1%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRL-EKKRIKKRKGESMALNEK-QILEKVNSQFVV 247 +++GKG FG+V + A K + +KR ++ E + + E + +K S V+ Sbjct: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 Query: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENT 307 ++ ++ ++ +C+ +++ DL I GF + +A IL L+ LH+ Sbjct: 273 HMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 Query: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD 367 ++ DLKPENILL +G + E + + + Y APE++ RY D Sbjct: 332 IHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPID 391 Query: 368 YWGLGCLIYEMIEGQSPFRGRKE 390 W GC++ E++ GQ F G E Sbjct: 392 IWSFGCILAELLTGQPLFPGEDE 414 >3ZUT-A nrPDB Length = 362 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 74/282 (26%), Positives = 121/282 (42%), Gaps = 32/282 (11%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF-----V 246 +G G FG + + + ++ A K +E+ GE + N K+ E +N + + Sbjct: 27 IGSGNFGVARLMRDKQSNELVAVKYIER-------GEKIDENVKR--EIINHRSLRHPNI 77 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 V T L +V+ +GG+L I N G F E+ A F+ +++ G+ H Sbjct: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHAMQ 135 Query: 307 TVYRDLKPENILLDD--YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-G 363 +RDLK EN LLD ++I G + + VGT Y+APEVL + Y G Sbjct: 136 VCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV---YSHKFSEEAKSIC 420 D W G +Y M+ G PF +E + R+L + Y H S E + + Sbjct: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH-ISPECRHLI 254 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLD 462 + D +R+ E++ H +F K L A +++ Sbjct: 255 SRIFVADPAKRISI-----PEIRNHEWF----LKNLPADLMN 287 >4EWQ-A nrPDB Length = 383 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 97/202 (48%), Gaps = 12/202 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G +G VCA TG A K+L + + E ++L+ + + V+ L Sbjct: 53 VGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHMKHENVIGLLD 111 Query: 252 AYETKDAL-----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 + +L ++T + G DL + ++ F +IL GL+ +H + Sbjct: 112 VFTPARSLEEFNDVYLVTHLMGADLNNIV---KCQKLTDDHVQFLIYQILRGLKYIHSAD 168 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV-LNNQRYGLS 365 ++RDLKP N+ +++ ++I D GLA D + G V T Y APE+ LN Y + Sbjct: 169 IIHRDLKPSNLAVNEDCELKILDFGLARHT--DDEMTGYVATRWYRAPEIMLNWMHYNQT 226 Query: 366 PDYWGLGCLIYEMIEGQSPFRG 387 D W +GC++ E++ G++ F G Sbjct: 227 VDIWSVGCIMAELLTGRTLFPG 248 >1NY3-A nrPDB Length = 400 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 122/277 (44%), Gaps = 37/277 (13%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ--FVV 247 +VLG G G+V + T + +A K L+ +R+ E L SQ +V Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---------LHWRASQCPHIV 118 Query: 248 NLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + YE + L +V+ ++GG+L I + G+ F E A I ++ LH Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 304 RENTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 N +RD+KPEN+L ++++D G A + + + T Y+APEVL + Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFR---------GRKEKVKREEVDRRVLETEEVYSHK 411 +Y S D W LG ++Y ++ G PF G K +++ + + E EV Sbjct: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV---- 294 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 SEE K + + LL + QR+ E HP+ Sbjct: 295 -SEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI 325 >2OZA-A nrPDB Length = 356 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 122/277 (44%), Gaps = 37/277 (13%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ--FVV 247 +VLG G G+V + T + +A K L+ +R+ E L SQ +V Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---------LHWRASQCPHIV 74 Query: 248 NLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + YE + L +V+ ++GG+L I + G+ F E A I ++ LH Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 304 RENTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 N +RD+KPEN+L ++++D G A + + + T Y+APEVL + Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 194 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFR---------GRKEKVKREEVDRRVLETEEVYSHK 411 +Y S D W LG ++Y ++ G PF G K +++ + + E EV Sbjct: 195 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV---- 250 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 SEE K + + LL + QR+ E HP+ Sbjct: 251 -SEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI 281 >1UA2-A nrPDB Length = 346 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 102/198 (51%), Gaps = 6/198 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLE-KKRIKKRKG-ESMALNEKQILEKVNS 243 + + LG+G F V + + T ++ A K+++ R + + G AL E ++L++++ Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L A+ K + LV M DL+ I + + Y L GLE LH Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKD-NSLVLTPSHIKAYMLMTLQGLEYLH 129 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLNNQR- 361 + ++RDLKP N+LLD+ G ++++D GLA + +V T Y APE+L R Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 Query: 362 YGLSPDYWGLGCLIYEMI 379 YG+ D W +GC++ E++ Sbjct: 190 YGVGVDMWAVGCILAELL 207 >4NST-A nrPDB Length = 351 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 112/222 (50%), Gaps = 16/222 (7%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 ++G+G +G+V + + TG++ A K++ +K A+ E +IL ++ + VVN+ Sbjct: 20 IIGEGTYGQVYKAKDKDTGELVALKKVRLDN-EKEGFPITAIREIKILRQLIHRSVVNMK 78 Query: 251 -YAYETKDAL---------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + +DAL LV M+ DL + G F E+ + +++ GLE Sbjct: 79 EIVTDKQDALDFKKDKGAFYLVFEYMDH-DL-MGLLESGLVHFSEDHIKSFMKQLMEGLE 136 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLA--VKIPEGDLIRGRVGTVGYMAPE-VL 357 H++N ++RD+K NILL++ G I+++D GLA E +V T+ Y PE +L Sbjct: 137 YCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLL 196 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 +RY + D W GC++ E+ + F+ E + E + R Sbjct: 197 GEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISR 238 >3KA0-A nrPDB Length = 320 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 122/277 (44%), Gaps = 37/277 (13%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ--FVV 247 +VLG G G+V + T + +A K L+ +R+ E L SQ +V Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---------LHWRASQCPHIV 72 Query: 248 NLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + YE + L +V+ ++GG+L I + G+ F E A I ++ LH Sbjct: 73 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 304 RENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 N +RD+KPEN+L ++++D G A + + + T Y+APEVL + Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPE 192 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFR---------GRKEKVKREEVDRRVLETEEVYSHK 411 +Y S D W LG ++Y ++ G PF G K +++ + + E EV Sbjct: 193 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV---- 248 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 SEE K + + LL + QR+ E HP+ Sbjct: 249 -SEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI 279 >4CSV-A nrPDB Length = 275 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 62/215 (28%), Positives = 103/215 (47%), Gaps = 11/215 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R LG G FGEV + R A K L++ + + L E QI++K+ +V L Sbjct: 17 RKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEE----FLQEAQIMKKLKHPNLVQL 72 Query: 250 AYAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV 308 Y TK+ ++T M+ G L ++ + + L AA++ G+ L +N + Sbjct: 73 -YGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFI 131 Query: 309 YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGYMAPEVLNNQRYGLS 365 +RDL N L+ + ++++D GLA I E D R G + + APE ++ R+ + Sbjct: 132 HRDLAARNCLVGENNVVKVADFGLARLINE-DEYTARAGAKFPIKWTAPEAISYNRFSIK 190 Query: 366 PDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDR 399 D W G L++E+ GQ P+ G E+V+R Sbjct: 191 SDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVER 225 >2XS0-A nrPDB Length = 386 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 99/208 (47%), Gaps = 12/208 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++ + +G G G VCA + A K+L + + + A E +++ VN + Sbjct: 28 YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHKN 86 Query: 246 VVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 ++ L + + +L +V+ +M+ ++ + + ER + ++LCG+ Sbjct: 87 IIGLLNVFTPQKSLEEFQDVYIVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 141 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 + LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 142 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILG 201 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 Y + D W +GC++ EMI+G F G Sbjct: 202 MGYKENVDIWSVGCIMGEMIKGGVLFPG 229 >4RC3-A nrPDB Length = 289 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 79/281 (28%), Positives = 126/281 (44%), Gaps = 41/281 (14%) Query: 188 QYRV---LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR----KGESMALNEKQILEK 240 QY+V LG GGFG V + + A K +EK RI G + + E +L+K Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLKK 71 Query: 241 VNSQF--VVNLAYAYETKDALCLVLTIMNG-GDLKFHIYNMGNPGFEEERALFYAAEILC 297 V+S F V+ L +E D+ L+L DL I G +EE A + ++L Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLE 129 Query: 298 GLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRV-----GTVGY 351 + H ++RD+K ENIL+D + G +++ D G G L++ V GT Y Sbjct: 130 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG------SGALLKDTVYTDFDGTRVY 183 Query: 352 MAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 PE + RY G S W LG L+Y+M+ G PF E D ++ + + Sbjct: 184 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----------EHDEEIIRGQVFFRQ 233 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 + S E + + + L R + E++ HP+ +++ Sbjct: 234 RVSSECQHLIRWCLALRPSDRPTFE-----EIQNHPWMQDV 269 >2PMN-X nrPDB Length = 348 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 62/235 (26%), Positives = 104/235 (44%), Gaps = 26/235 (11%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN 233 K+++ + N +R R L +G F ++ C+ K YA K+ EK ++K++ + + N Sbjct: 21 KYVKEKDKYINDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNN 78 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLT-IMNGGDLKFHIYN-MGNPGFEEERALFY 291 +K ++ F L + K+ CL I+ D + IY M N + F+ Sbjct: 79 DKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFF 138 Query: 292 AAE------------------ILCGLEDLHRE-NTVYRDLKPENILLDDYGHIRISDLGL 332 + +L +H E N +RD+KP NIL+D G +++SD G Sbjct: 139 VLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGE 198 Query: 333 AVKIPEGDLIRGRVGTVGYMAPEVLNNQRY--GLSPDYWGLGCLIYEMIEGQSPF 385 + + + I+G GT +M PE +N+ G D W LG +Y M PF Sbjct: 199 SEYMVDKK-IKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF 252 >5ZTN-A nrPDB Length = 429 Score = 79.3 bits (194), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 96/207 (46%), Gaps = 11/207 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLE-KKRIKKRKGESMALNEK-QILEKVNSQFVV 247 +V+GKG FG+V + A K + +KR ++ E + + E + +K N+ V+ Sbjct: 103 KVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVI 162 Query: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP----GFEEERALFYAAEILCGLEDLH 303 ++ + ++ +C+ + L ++Y + GF +A IL L+ LH Sbjct: 163 HMLENFTFRNHICMTFEL-----LSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALH 217 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 + ++ DLKPENILL G I + E + + + Y APEV+ RYG Sbjct: 218 KNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYG 277 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKE 390 + D W LGC++ E++ G G E Sbjct: 278 MPIDMWSLGCILAELLTGYPLLPGEDE 304 >2BRG-A nrPDB Length = 297 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 104/208 (50%), Gaps = 24/208 (11%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKR-------IKKRKGESMALNEKQILEKVN 242 + LG+G +GEV R T + A K ++ KR IKK + LN + +++ Sbjct: 13 QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYG 72 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY-NMGNPGFEEERALFYAAEILCGLED 301 + N+ Y L L +GG+L I ++G P + +R + +++ G+ Sbjct: 73 HRREGNIQY---------LFLEYCSGGELFDRIEPDIGMPEPDAQR---FFHQLMAGVVY 120 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---LIRGRVGTVGYMAPEVLN 358 LH +RD+KPEN+LLD+ +++ISD GLA + L+ GT+ Y+APE+L Sbjct: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180 Query: 359 NQRYGLSP-DYWGLGCLIYEMIEGQSPF 385 + + P D W G ++ M+ G+ P+ Sbjct: 181 RREFHAEPVDVWSCGIVLTAMLAGELPW 208 >2XNP-A nrPDB Length = 279 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 69/256 (26%), Positives = 117/256 (45%), Gaps = 31/256 (12%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 +G G +G + ++ GK+ K L+ + + + + M ++E +L ++ N+ Sbjct: 13 TIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAE-KQMLVSEVNLLRELKHP---NIV 68 Query: 251 YAYE-----TKDALCLVLTIMNGGDLKFHIYNMGNPG---FEEERALFYAAEILCGLEDL 302 Y+ T L +V+ GGDL + G +EE L ++ L++ Sbjct: 69 RYYDRIIDRTNTTLYIVMEYCEGGDLA-SVITKGTKERQYLDEEFVLRVMTQLTLALKEC 127 Query: 303 HREN-----TVYRDLKPENILLDDYGHIRISDLGLA-VKIPEGDLIRGRVGTVGYMAPEV 356 HR + ++RDLKP N+ LD ++++ D GLA + + + VGT YM+PE Sbjct: 128 HRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQ 187 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK----VKREEVDRRVLETEEVYSHKF 412 +N Y D W LGCL+YE+ PF +K RE RR+ +++ Sbjct: 188 MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRI-------PYRY 240 Query: 413 SEEAKS-ICKMLLTKD 427 S+E I +ML KD Sbjct: 241 SDELNEIITRMLNLKD 256 >3BGP-A nrPDB Length = 333 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 79/281 (28%), Positives = 126/281 (44%), Gaps = 41/281 (14%) Query: 188 QYRV---LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR----KGESMALNEKQILEK 240 QY+V LG GGFG V + + A K +EK RI G + + E +L+K Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLKK 115 Query: 241 VNSQF--VVNLAYAYETKDALCLVLTIMNG-GDLKFHIYNMGNPGFEEERALFYAAEILC 297 V+S F V+ L +E D+ L+L DL I G +EE A + ++L Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLE 173 Query: 298 GLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRV-----GTVGY 351 + H ++RD+K ENIL+D + G +++ D G G L++ V GT Y Sbjct: 174 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG------SGALLKDTVYTDFDGTRVY 227 Query: 352 MAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 PE + RY G S W LG L+Y+M+ G PF E D ++ + + Sbjct: 228 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----------EHDEEIIRGQVFFRQ 277 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 + S E + + + L R + E++ HP+ +++ Sbjct: 278 RVSSECQHLIRWCLALRPSDRPTFE-----EIQNHPWMQDV 313 >2A1A-B nrPDB Length = 284 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 99/211 (46%), Gaps = 25/211 (11%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F++ ++G GGFG+V + R GK Y KR++ K A E + L K++ Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK-------AEREVKALAKLDHVN 65 Query: 246 VVNLAYAYETKD----------------ALCLVLTIMNGGDLKFHIYNMGNPGFEEERAL 289 +V+ ++ D L + + + G L+ I ++ AL Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGT 348 +I G++ +H + + RDLKP NI L D ++I D GL + +G R + GT Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK-GT 184 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMI 379 + YM+PE +++Q YG D + LG ++ E++ Sbjct: 185 LRYMSPEQISSQDYGKEVDLYALGLILAELL 215 >5B2L-A nrPDB Length = 324 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 65/256 (25%), Positives = 119/256 (46%), Gaps = 29/256 (11%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G G+V + R TG + A K++ ++ K + + + ++ +L+ + ++V Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVKQM-RRSGNKEENKRILMDLDVVLKSHDCPYIVQCFG 83 Query: 252 AYETKDALCLVLTIM--NGGDLKFHIYN------MGNPGFEEERALFYAAEILCGLEDLH 303 + T + + + +M + LK + +G +AL+Y E Sbjct: 84 TFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE--------- 134 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN----- 358 + ++RD+KP NILLD+ G I++ D G++ ++ + G YMAPE ++ Sbjct: 135 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 194 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEE--VYSHK-FSEE 415 Y + D W LG + E+ GQ P++ K EV +VL+ E + H FS + Sbjct: 195 KPDYDIRADVWSLGISLVELATGQFPYKNCKTDF---EVLTKVLQEEPPLLPGHMGFSGD 251 Query: 416 AKSICKMLLTKDAKQR 431 +S K LTKD ++R Sbjct: 252 FQSFVKDCLTKDHRKR 267 >4O2Z-A nrPDB Length = 377 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 98/210 (46%), Gaps = 17/210 (8%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRL--------EKKRIKKRKGESMALNEKQILEKV 241 ++LG G +G C+C TG+ + K+ + KR+ + + + +L V Sbjct: 51 KILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVV 110 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 N + L Y + + + +V +M D+ ++ EE ++ +IL GL+ Sbjct: 111 N--ILPPLKREYHSFEDVYVVTPLM---DVDMNVVLRSRQVLEESHMQYFVYQILRGLKY 165 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGL--AVKIPEGDLIRGRVGTVGYMAPE-VLN 358 LH N +RDLKP N++ + ++I D GL +V +P +L V T Y PE +L Sbjct: 166 LHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELT-DYVITRWYRPPELLLE 224 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 N Y + D W +GC+ EM + F GR Sbjct: 225 NTNYSTAVDIWSVGCIFAEMYNRKPVFPGR 254 >5TOS-A nrPDB Length = 395 Score = 78.2 bits (191), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 73/226 (32%), Positives = 107/226 (47%), Gaps = 28/226 (12%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVR---------ATGKMYACKRLEKKRIKKRKG 227 E + T+N FR V+G+GGFG V + TG + A K+L ++ + G Sbjct: 59 ELKLATRN-FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---G 114 Query: 228 ESMALNEKQILEKVNSQFVVNL-AYAYETKDALCLVLTIMNGGDLKFHIYNMGN-----P 281 L E L +++ +V L Y E + L LV M G L+ H++ G P Sbjct: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 Query: 282 GFEEERALFYAAEILCGLEDLHRE--NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG 339 F AA+ GL LH + +YRD+K NILLD + ++SD GLA P G Sbjct: 174 WFLRVNVALDAAK---GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 Query: 340 DL--IRGRV-GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQ 382 DL + RV GT GY APE +++ D + G L+ E++ G+ Sbjct: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 >6GU6-A nrPDB Length = 302 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 106/205 (51%), Gaps = 11/205 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G +G V + + TG++ A K++ + ++ S A+ E +L+++ +V+L Sbjct: 15 IGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKELRHPNIVSLQD 73 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF--YAAEILCGLEDLHRENTVY 309 L L+ ++ DLK ++ ++ PG + +L Y +IL G+ H ++ Sbjct: 74 VLMQDSRLYLIFEFLSM-DLKKYLDSI-PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 131 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR---GRVGTVGYMAPEV-LNNQRYGLS 365 RDLKP+N+L+DD G I+++D GLA G IR V T+ Y +PEV L + RY Sbjct: 132 RDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGSARYSTP 189 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKE 390 D W +G + E+ + F G E Sbjct: 190 VDIWSIGTIFAELATKKPLFHGDSE 214 >4IDT-A nrPDB Length = 356 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 65/207 (31%), Positives = 97/207 (46%), Gaps = 21/207 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G FGEV + + TG + C +KK + E E + S +V L Sbjct: 82 LGRGSFGEVHRMEDKQTG--FQCA------VKKVRLEVFRAEELMACAGLTSPRIVPLYG 133 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 A + + + ++ GG L + G E+RAL+Y + L GLE LH ++ D Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGC--LPEDRALYYLGQALEGLEYLHSRRILHGD 191 Query: 312 LKPENILL-DDYGHIRISDLGLAVKI-PEG---DLIRGRV--GTVGYMAPEVLNNQRYGL 364 +K +N+LL D H + D G AV + P+G DL+ G GT +MAPEV+ + Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDA 251 Query: 365 SPDYWGLGCLIYEMIEGQSP----FRG 387 D W C++ M+ G P FRG Sbjct: 252 KVDVWSSCCMMLHMLNGCHPWTQFFRG 278 >4QTB-A nrPDB Length = 380 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 105/218 (48%), Gaps = 26/218 (11%) Query: 186 FRQYRVLGKGGFGEVCAC--QVRATGKMYACKRLEKKRIKKRKGESM---ALNEKQILEK 240 + Q + +G+G +G V + VR T R+ K+I + ++ L E QIL + Sbjct: 43 YTQLQYIGEGAYGMVSSAYDHVRKT-------RVAIKKISPFEHQTYCQRTLREIQILLR 95 Query: 241 VNSQFVVNL-----AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 + V+ + A E + +V +M K + + + ++ +I Sbjct: 96 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKL----LKSQQLSNDHICYFLYQI 151 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA-VKIPEGD---LIRGRVGTVGY 351 L GL+ +H N ++RDLKP N+L++ ++I D GLA + PE D + V T Y Sbjct: 152 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 211 Query: 352 MAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 APE+ LN++ Y S D W +GC++ EM+ + F G+ Sbjct: 212 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 249 >4EQM-A nrPDB Length = 294 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 95/203 (46%), Gaps = 14/203 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRL-----EKKRIKKRKGESMALNEKQILEKVNSQFV 246 LG GG V + A K + EK+ KR E N Q+ + Q + Sbjct: 19 LGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKR-FEREVHNSSQL----SHQNI 73 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 V++ E D LV+ + G L +I + G + A+ + +IL G++ H Sbjct: 74 VSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHG--PLSVDTAINFTNQILDGIKHAHDMR 131 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR--VGTVGYMAPEVLNNQRYGL 364 V+RD+KP+NIL+D ++I D G+A + E L + +GTV Y +PE + Sbjct: 132 IVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATDE 191 Query: 365 SPDYWGLGCLIYEMIEGQSPFRG 387 D + +G ++YEM+ G+ PF G Sbjct: 192 CTDIYSIGIVLYEMLVGEPPFNG 214 >4HVI-A nrPDB Length = 314 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/199 (29%), Positives = 97/199 (48%), Gaps = 16/199 (8%) Query: 192 LGKGGFGEVCACQVRA----TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 LGKG FG V C+ TG + A K+L+ +++ E QIL+ ++S F+V Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQ---REIQILKALHSDFIV 74 Query: 248 ---NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 ++Y + +L LV+ + G L+ + R L Y+++I G+E L Sbjct: 75 KYRGVSYG-PGRQSLRLVMEYLPSGCLR-DFLQRHRARLDASRLLLYSSQICKGMEYLGS 132 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGR---VGTVGYMAPEVLNNQ 360 V+RDL NIL++ H++I+D GLA +P + D R + + APE L++ Sbjct: 133 RRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDN 192 Query: 361 RYGLSPDYWGLGCLIYEMI 379 + D W G ++YE+ Sbjct: 193 IFSRQSDVWSFGVVLYELF 211 >3UIU-A nrPDB Length = 306 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/224 (26%), Positives = 101/224 (45%), Gaps = 38/224 (16%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F++ ++G GGFG+V + R GK Y +R++ K A E + L K++ Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK-------AEREVKALAKLDHVN 66 Query: 246 VVN-------LAYAYETKD----------------------ALCLVLTIMNGGDLKFHIY 276 +V+ Y ET D L + + + G L+ I Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 277 NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI 336 ++ AL +I G++ +H + ++RDLKP NI L D ++I D GL + Sbjct: 127 KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 337 P-EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMI 379 +G R + GT+ YM+PE +++Q YG D + LG ++ E++ Sbjct: 187 KNDGKRTRSK-GTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >3LLT-A nrPDB Length = 360 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 72/246 (29%), Positives = 101/246 (41%), Gaps = 32/246 (13%) Query: 168 DRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK--RLEKKRIKKR 225 D + + W ++ + N F R +G G FG V CQ K YA K R KK + Sbjct: 20 DEIVHFSW-KKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSA 78 Query: 226 KGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEE 285 K E+ L + Q + N+ +V + D +CL+ + G L I GF Sbjct: 79 KIEADILKKIQNDDINNNN-IVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHI 136 Query: 286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD------------------------ 321 E Y EIL L L + + + DLKPENILLDD Sbjct: 137 EDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRT 196 Query: 322 -YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE 380 I++ D G A + D + T Y APEV+ N + +S D W GC++ E+ Sbjct: 197 KSTGIKLIDFGCAT--FKSDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYT 254 Query: 381 GQSPFR 386 G FR Sbjct: 255 GSLLFR 260 >5Z33-A nrPDB Length = 425 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 105/224 (46%), Gaps = 24/224 (10%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRL----EKKRIKKRKGESMAL 232 ER VTK LG+G +G VCA T + A K++ KK + KR AL Sbjct: 31 ERYTVTKE-------LGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKR-----AL 78 Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF-- 290 E ++L+ + Y + T + ++ + + G A F Sbjct: 79 REIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQS 138 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI---PE--GDLIRGR 345 + +ILCGL+ +H N ++RDLKP N+L++ ++I D GLA PE + Sbjct: 139 FIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEY 198 Query: 346 VGTVGYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 V T Y APE+ L+ Q Y + D W +GC++ E++ G+ F+GR Sbjct: 199 VATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGR 242 >5AIR-A nrPDB Length = 430 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 75/308 (24%), Positives = 132/308 (42%), Gaps = 51/308 (16%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKR-LEKKRIKKRKGESMALNEKQILEKVNS 243 ++ +V+G G FG V ++ +G++ A K+ L+ KR K R E QI+ K++ Sbjct: 65 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR--------ELQIMRKLDH 116 Query: 244 QFVVNLAYAY----ETKDALCLVLTIMNGGDLKFHI---YNMGNPGFEEERALFYAAEIL 296 +V L Y + E KD + L L + + + + Y+ Y ++ Sbjct: 117 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 176 Query: 297 CGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 L +H +RD+KP+N+LLD D +++ D G A ++ G+ + + Y APE Sbjct: 177 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 236 Query: 356 -VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG-----------------RKEKVKREEV 397 + Y S D W GC++ E++ GQ F G +E+++ Sbjct: 237 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 296 Query: 398 DRRVLETEEVYSHKFSE--------EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF- 448 + + ++ +H +++ EA ++C LL RL E A H FF Sbjct: 297 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA-----HSFFD 351 Query: 449 --RNMNFK 454 R+ N K Sbjct: 352 ELRDPNVK 359 >4E93-A nrPDB Length = 377 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 98/214 (45%), Gaps = 11/214 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G FGEV + ++RA + A K + K + L E +IL++ + +V L Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK--FLQEARILKQYSHPNIVRLIG 179 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 K + +V+ ++ GGD + G + L + G+E L + ++RD Sbjct: 180 VCTQKQPIYIVMELVQGGDFLTFLRTEGA-RLRVKTLLQMVGDAAAGMEYLESKCCIHRD 238 Query: 312 LKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG-----TVGYMAPEVLNNQRYGLSP 366 L N L+ + ++ISD G++ + E D + G V + APE LN RY Sbjct: 239 LAARNCLVTEKNVLKISDFGMSRE--EADGVYAASGGLRQVPVKWTAPEALNYGRYSSES 296 Query: 367 DYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDR 399 D W G L++E G SP+ + RE V++ Sbjct: 297 DVWSFGILLWETFSLGASPYPNLSNQQTREFVEK 330 >5KKR-C nrPDB Length = 395 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 98/205 (47%), Gaps = 10/205 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACK--RLEKKRIKKRKGESMALNEKQILEKV 241 + F + LG G G V + +G + A K LE K + + + E Q+L + Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ----IIRELQVLHEC 123 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 NS ++V A+ + + + + M+GG L + G E+ + ++ GL Sbjct: 124 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTY 181 Query: 302 LHRENTV-YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 L ++ + +RD+KP NIL++ G I++ D G++ ++ + + VGT YM+PE L Sbjct: 182 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGT 240 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPF 385 Y + D W +G + EM G+ P Sbjct: 241 HYSVQSDIWSMGLSLVEMAVGRYPI 265 >3VN9-A nrPDB Length = 340 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 64/266 (24%), Positives = 128/266 (48%), Gaps = 19/266 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G +G V + +G++ A KR+ + + ++ + + ++ + V+ F V Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 Query: 252 AYETKDALCLVLTIMNGGDLKFH--IYNMGNPGFEEERALFYAAEILCGLEDLHRE-NTV 308 A + + + + +M+ KF+ + + G E+ A I+ LE LH + + + Sbjct: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQ-TIPEDILGKIAVSIVKALEHLHSKLSVI 176 Query: 309 YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN---NQR-YGL 364 +RD+KP N+L++ G +++ D G++ + + G YMAPE +N NQ+ Y + Sbjct: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE--TEEVYSHKFSEEAKSICKM 422 D W LG + E+ + P+ ++ ++V+E + ++ + KFS E Sbjct: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQL---KQVVEEPSPQLPADKFSAEFVDFTSQ 293 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFF 448 L K++K+R E+ +HPFF Sbjct: 294 CLKKNSKER-----PTYPELMQHPFF 314 >2PL0-A nrPDB Length = 289 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 100/217 (46%), Gaps = 11/217 (5%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNE 234 W + V + T + LG G FGEV K+ A K L++ + L E Sbjct: 14 WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV-AVKSLKQGSMSP----DAFLAE 68 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 +++++ Q +V L YA T++ + ++ M G L + + L AA+ Sbjct: 69 ANLMKQLQHQRLVRL-YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 127 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGY 351 I G+ + N ++RDL+ NIL+ D +I+D GLA ++ E + R G + + Sbjct: 128 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLA-RLIEDNEYTAREGAKFPIKW 186 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMI-EGQSPFRG 387 APE +N + + D W G L+ E++ G+ P+ G Sbjct: 187 TAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >3EQC-A nrPDB Length = 360 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 98/203 (48%), Gaps = 6/203 (2%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + F + LG G G V + +G + A ++L IK + + E Q+L + NS Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAI-RNQIIRELQVLHECNS 90 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++V A+ + + + + M+GG L + G E+ + ++ GL L Sbjct: 91 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 148 Query: 304 RENTV-YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 ++ + +RD+KP NIL++ G I++ D G++ ++ + + VGT YM+PE L Y Sbjct: 149 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHY 207 Query: 363 GLSPDYWGLGCLIYEMIEGQSPF 385 + D W +G + EM G+ P Sbjct: 208 SVQSDIWSMGLSLVEMAVGRYPI 230 >2F9G-A nrPDB Length = 353 Score = 75.1 bits (183), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 102/220 (46%), Gaps = 23/220 (10%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL-----EK 240 F+ +LG+G +G VC+ + TG++ A K++E K L E +IL E Sbjct: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKHEN 70 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + + F + ++E + + ++ +M DL I ++ ++ + L ++ Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI---STQMLSDDHIQYFIYQTLRAVK 126 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-----------IRGRVGTV 349 LH N ++RDLKP N+L++ +++ D GLA I E + V T Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 350 GYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 Y APEV L + +Y + D W GC++ E+ + F GR Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 >1ZXE-A nrPDB Length = 303 Score = 75.1 bits (183), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 69/279 (24%), Positives = 121/279 (43%), Gaps = 36/279 (12%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F + VLG+G FG+V + + YA K++ K S L+E +L +N Q+ Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKL----STILSEVMLLASLNHQY 63 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKF---------HIYNM-GNPGFEEERALFYAA-- 293 VV A+ + +T + F +Y++ + ++R ++ Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP---------------E 338 +IL L +H + ++R+LKP NI +D+ +++I D GLA + Sbjct: 124 QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 339 GDLIRGRVGTVGYMAPEVLNNQ-RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEV 397 D + +GT Y+A EVL+ Y D + LG + +EMI PF E+V + Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILKK 240 Query: 398 DRRV-LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 R V +E + + K I ++L+ D +R G + Sbjct: 241 LRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGAR 279 >5NGU-A nrPDB Length = 381 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 97/207 (46%), Gaps = 16/207 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL-- 249 +G+G +G VC+ A K++ + + L E +IL + + ++ + Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHENIIGIND 107 Query: 250 ---AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 A E + +V +M K + + ++ +IL GL+ +H N Sbjct: 108 IIRAPTIEQMKDVYIVQDLMETDLYKL----LKTQHLSNDHICYFLYQILRGLKYIHSAN 163 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLA-VKIPEGD---LIRGRVGTVGYMAPEV-LNNQR 361 ++RDLKP N+LL+ ++I D GLA V P+ D + V T Y APE+ LN++ Sbjct: 164 VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKG 223 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGR 388 Y S D W +GC++ EM+ + F G+ Sbjct: 224 YTKSIDIWSVGCILAEMLSNRPIFPGK 250 >2DQ7-X nrPDB Length = 283 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 108/222 (48%), Gaps = 9/222 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + + + + + LG G FGEV K+ A K L+ + ES L E QI++K Sbjct: 6 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKV-AIKTLKPGTMSP---ESF-LEEAQIMKK 60 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + +V L YA +++ + +V MN G L + + + + AA++ G+ Sbjct: 61 LKHDKLVQL-YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMA 119 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMAPEVLN 358 + R N ++RDL+ NIL+ + +I+D GLA I + + +G + + APE Sbjct: 120 YIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 179 Query: 359 NQRYGLSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDR 399 R+ + D W G L+ E++ +G+ P+ G + E+V+R Sbjct: 180 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVER 221 >4AN9-A nrPDB Length = 301 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/250 (26%), Positives = 117/250 (46%), Gaps = 10/250 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + F + LG G G V + +G + A ++L IK + + E Q+L + NS Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAI-RNQIIRELQVLHECNS 66 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++V A+ + + + + M+GG L + G E+ + ++ GL L Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 124 Query: 304 RENTV-YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 ++ + +RD+KP NIL++ G I++ D G++ ++ + ++ VGT YM+PE L Y Sbjct: 125 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-EMANEFVGTRSYMSPERLQGTHY 183 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE-TEEVYSHKFSEEAKSICK 421 + D W +G + EM G+ P R E +D V E ++ S FS E + Sbjct: 184 SVQSDIWSMGLSLVEMAVGRYP---RPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVN 240 Query: 422 MLLTKDAKQR 431 L K+ +R Sbjct: 241 KCLIKNPAER 250 >3FME-A nrPDB Length = 290 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/266 (24%), Positives = 128/266 (48%), Gaps = 19/266 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G +G V + +G++ A KR+ + + ++ + + ++ + V+ F V Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 73 Query: 252 AYETKDALCLVLTIMNGGDLKFH--IYNMGNPGFEEERALFYAAEILCGLEDLHRE-NTV 308 A + + + + +M+ KF+ + + G E+ A I+ LE LH + + + Sbjct: 74 ALFREGDVWICMELMDTSLDKFYKQVIDKGQ-TIPEDILGKIAVSIVKALEHLHSKLSVI 132 Query: 309 YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN---NQR-YGL 364 +RD+KP N+L++ G +++ D G++ + + G YMAPE +N NQ+ Y + Sbjct: 133 HRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPELNQKGYSV 192 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE--TEEVYSHKFSEEAKSICKM 422 D W LG + E+ + P+ ++ ++V+E + ++ + KFS E Sbjct: 193 KSDIWSLGITMIELAILRFPYDSWGTPFQQL---KQVVEEPSPQLPADKFSAEFVDFTSQ 249 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFF 448 L K++K+R E+ +HPFF Sbjct: 250 CLKKNSKER-----PTYPELMQHPFF 270 >4QNY-A nrPDB Length = 354 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 99/207 (47%), Gaps = 11/207 (5%) Query: 190 RVLGKGGFGEVC-ACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVN 248 R++G G +G V A ++ ++ A KR+ K+ ++ L E ++L N ++ Sbjct: 26 RIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIG 85 Query: 249 LAYAY-----ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 L E D +V+ IM DLK + G E F+ + L L +H Sbjct: 86 LRNILTPEDPENFDHFYIVMDIMET-DLK-QVLRSGQE-LTEAHIQFFIYQALRALHIIH 142 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAV-KIPEGDLIRGRVGTVGYMAPE-VLNNQR 361 ++RD+ P NIL++ ++I D GLA + +G+ + V Y APE V+ ++ Sbjct: 143 SAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKD 202 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGR 388 Y D WG+GC++ E++ + F+G+ Sbjct: 203 YSAQIDVWGIGCILGELLGSRPLFQGK 229 >5HI2-A nrPDB Length = 283 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 91/200 (45%), Gaps = 17/200 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G FG V + A K L ++++ K NE +L K ++ L Sbjct: 28 IGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFK------NEVGVLRKTRHVNIL-LFM 77 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 Y TK L +V G L H++ FE ++ + A + G++ LH ++ ++RD Sbjct: 78 GYSTKPQLAIVTQWCEGSSLYHHLH-ASETKFEMKKLIDIARQTARGMDYLHAKSIIHRD 136 Query: 312 LKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMAPEVLNNQR---YGLS 365 LK NI L + ++I D GLA + G++ +MAPEV+ Q Y Sbjct: 137 LKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQ 196 Query: 366 PDYWGLGCLIYEMIEGQSPF 385 D + G ++YE++ GQ P+ Sbjct: 197 SDVYAFGIVLYELMTGQLPY 216 >4U41-A nrPDB Length = 332 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 99/216 (45%), Gaps = 23/216 (10%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F V+G G +G+V + TG++ A K ++ + + + E + L E +L+K + Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD---VTEDEEEEIKL-EINMLKKYSHHR 81 Query: 246 VVNLAYAYETK-------DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + Y K D L LV+ G + + N +E+ + + EIL G Sbjct: 82 NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 141 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR----VGTVGYMAP 354 L LH + ++RD+K +N+LL + +++ D G++ ++ D GR +GT +MAP Sbjct: 142 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL---DRTVGRRNTFIGTPYWMAP 198 Query: 355 EVLN-----NQRYGLSPDYWGLGCLIYEMIEGQSPF 385 EV+ + Y D W G EM EG P Sbjct: 199 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPL 234 >4X7Q-B nrPDB Length = 312 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 72/264 (27%), Positives = 112/264 (42%), Gaps = 29/264 (10%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN---EKQILEKVN 242 +R +LGKGGFG V A A K + + R+ S ++ E +L KV Sbjct: 33 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVG 92 Query: 243 S----QFVVNLAYAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + V+ L +ET++ LVL + DL +I G G R F +++ Sbjct: 93 AGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFF--GQVVA 150 Query: 298 GLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKI---PEGDLIRGRVGTVGYMA 353 ++ H V+RD+K ENIL+D G ++ D G + P D RV Y Sbjct: 151 AIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRV----YSP 206 Query: 354 PEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 PE ++ +Y L W LG L+Y+M+ G PF E D+ +LE E + Sbjct: 207 PEWISRHQYHALPATVWSLGILLYDMVCGDIPF----------ERDQEILEAELHFPAHV 256 Query: 413 SEEAKSICKMLLTKDAKQRLGCQE 436 S + ++ + L R +E Sbjct: 257 SPDCCALIRRCLAPKPSSRPSLEE 280 >4G3E-A nrPDB Length = 352 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 68/227 (29%), Positives = 102/227 (44%), Gaps = 37/227 (16%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNE 234 W+ QP RV G+G FGEV + + TG + C +KK + E + E Sbjct: 75 WMTHQP---------RV-GRGSFGEVHRMKDKQTG--FQCA------VKKVRLEVFRVEE 116 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 ++S +V L A + + + ++ GG L I MG E+RAL+Y + Sbjct: 117 LVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGC--LPEDRALYYLGQ 174 Query: 295 ILCGLEDLHRENTVYRDLKPENILLD---------DYGH-IRISDLGLAVKIPEGDLIRG 344 L GLE LH ++ D+K +N+LL D+GH + + GL + GD I Sbjct: 175 ALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIP- 233 Query: 345 RVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSP----FRG 387 GT +MAPEV+ + D W C++ M+ G P FRG Sbjct: 234 --GTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRG 278 >3ALO-A nrPDB Length = 327 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 127/272 (46%), Gaps = 27/272 (9%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G +G V + +G++ A KR+ + + +++ + + ++ ++ + ++V Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYG 88 Query: 252 AYETKDALCLVLTIMNGGDLKFH--IYNMGNPGFEEERALFYAAEILCGLEDLHREN--T 307 A + + + +M+ KF+ +Y++ + EE + L L +EN Sbjct: 89 ALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHL-KENLKI 147 Query: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN----NQRYG 363 ++RD+KP NILLD G+I++ D G++ ++ + G YMAPE ++ Q Y Sbjct: 148 IHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYD 207 Query: 364 LSPDYWGLGCLIYEMIEGQSP-------FRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 + D W LG +YE+ G+ P F + VK + ++ +EE +FS Sbjct: 208 VRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDP--PQLSNSEE---REFSPSF 262 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + + LTKD +R E+ +HPF Sbjct: 263 INFVNLCLTKDESKR-----PKYKELLKHPFI 289 >5L2Q-C nrPDB Length = 320 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/196 (29%), Positives = 100/196 (51%), Gaps = 21/196 (10%) Query: 256 KDALCLVLTIMNGGDLK---FHIYNMGNPGFEEER-------ALFYAAEILCGLEDLHRE 305 K +CLVL + D + N+ + +E+R +FY +++ +E LH++ Sbjct: 115 KKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFY--DVVRVVEALHQK 172 Query: 306 NTVYRDLKPENILLDDYGH-IRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRY- 362 N V+RDLK N++L+ H I I++ L + EGDL++ + G+ Y++P+VL+ + Y Sbjct: 173 NIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYR 232 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH--KFSEEAKSIC 420 G D W LG +++ M+ GQ PF +E+ R++ E + SE + Sbjct: 233 GKPSDMWALGVVLFTMLYGQFPFYDSIP----QELFRKIKAAEYTIPEDGRVSENTVCLI 288 Query: 421 KMLLTKDAKQRLGCQE 436 + LL D +QRL + Sbjct: 289 RKLLVLDPQQRLAAAD 304 >4XLV-A nrPDB Length = 328 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 98/222 (44%), Gaps = 15/222 (6%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG--ESMA-LNEKQI 237 V++ R LG+G FG V R K A R+ K + + E + LNE + Sbjct: 36 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV 95 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY--------NMGNPGFEEERAL 289 ++ VV L +V+ +M GDLK ++ N G P + + Sbjct: 96 MKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMI 155 Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRVGT 348 AAEI G+ L+ + V+RDL N ++ ++I D G+ I E D R G G Sbjct: 156 QMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGL 215 Query: 349 --VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 V +MAPE L + + S D W G +++E+ + P++G Sbjct: 216 LPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG 257 >2W96-B nrPDB Length = 306 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 87/205 (42%), Gaps = 6/205 (2%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRL-----EKKRIKKRKGESMALNEKQILEKVNSQFV 246 +G G +G V + +G A K + E+ E L + E N + Sbjct: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNVVRL 71 Query: 247 VNLAYAYETKDALCLVLTIMN-GGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 +++ T + + L + DL+ ++ PG E + L GL+ LH Sbjct: 72 MDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHAN 131 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLS 365 V+RDLKPENIL+ G ++++D GLA + V T+ Y APEVL Y Sbjct: 132 CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLLQSTYATP 191 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKE 390 D W +GC+ EM + F G E Sbjct: 192 VDMWSVGCIFAEMFRRKPLFCGNSE 216 >2UV2-A nrPDB Length = 325 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 106/230 (46%), Gaps = 14/230 (6%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F Q++ + R ++ + LG G FG+V Q + T + A K ++ K Sbjct: 16 ENLYFQSMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSE 75 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 ++ + + E IL + +V L A+ ++ L +++ GG + + + P Sbjct: 76 EELED---YMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERP- 131 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI 342 E + + L L LH ++RDLK NIL G I+++D G++ K I Sbjct: 132 LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK--NTRTI 189 Query: 343 RGR---VGTVGYMAPEVL-----NNQRYGLSPDYWGLGCLIYEMIEGQSP 384 + R +GT +MAPEV+ ++ Y D W LG + EM E + P Sbjct: 190 QRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPP 239 >6CTH-A nrPDB Length = 309 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 96/211 (45%), Gaps = 10/211 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 E VT N F LG+GGFG V +R + A K++ + ++G +E + Sbjct: 9 ELAKVTSN-FNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRA---SKQGIKEYASEVK 64 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I+ ++ + +V L + L LV M G L HI+ G E ++ Sbjct: 65 IISRLRHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFK-GKSLLTWEVRYRIVKDLA 123 Query: 297 CGLEDLHREN---TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV--GTVGY 351 L LH E ++RD+K NI+LD + ++ D GLA + ++ + GTVGY Sbjct: 124 SALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGY 183 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQ 382 MAPE L++ + D + G + E+ G+ Sbjct: 184 MAPECLSSGKASKESDVYSFGVVALEIASGR 214 >6GVJ-A nrPDB Length = 429 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 69/283 (24%), Positives = 125/283 (44%), Gaps = 31/283 (10%) Query: 187 RQYRVL---GKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-- 241 R Y +L G GG +V + ++YA K + + + +S NE L K+ Sbjct: 144 RIYSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYR-NEIAYLNKLQQ 201 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +S ++ L Y YE D + +M G++ + + + Y +L + Sbjct: 202 HSDKIIRL-YDYEITDQY--IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 258 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLI--RGRVGTVGYMAPEVLN 358 +H+ V+ DLKP N L+ D G +++ D G+A ++ P+ + +VGTV YM PE + Sbjct: 259 IHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 317 Query: 359 NQRYG-----------LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 + D W LGC++Y M G++PF+ ++ + + + E+ Sbjct: 318 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISK--LHAIIDPNHEI 375 Query: 408 YSHKFSE-EAKSICKMLLTKDAKQRLGCQEEGA---AEVKRHP 446 E + + + K L +D KQR+ E A +++ HP Sbjct: 376 EFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 418 >3HKO-A nrPDB Length = 345 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 72/307 (23%), Positives = 127/307 (41%), Gaps = 54/307 (17%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM--ALNEKQILEKVNSQFVVN 248 +G+G +G V T + A K + K +I++ + + E ++++K++ + Sbjct: 33 AIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIAR 92 Query: 249 LAYAYETKDALCLVLTIMNGGDL--KFHIY----------------------------NM 278 L YE + +CLV+ + +GG L K +++ N Sbjct: 93 LYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAING 152 Query: 279 GNPGFEEERALF--------YAAEILCGLEDLHRENTVYRDLKPENILL--DDYGHIRIS 328 GF E +I L LH + +RD+KPEN L + I++ Sbjct: 153 SIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLV 212 Query: 329 DLGLA---VKIPEGDL--IRGRVGTVGYMAPEVLN--NQRYGLSPDYWGLGCLIYEMIEG 381 D GL+ K+ G+ + + GT ++APEVLN N+ YG D W G L++ ++ G Sbjct: 213 DFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMG 272 Query: 382 QSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAE 441 PF G + +V + L E + S A+ + LL ++ +R A Sbjct: 273 AVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERF-----DAMR 327 Query: 442 VKRHPFF 448 +HP+ Sbjct: 328 ALQHPWI 334 >4GS6-A nrPDB Length = 315 Score = 72.4 bits (176), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/204 (28%), Positives = 94/204 (46%), Gaps = 24/204 (11%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 V+G+G FG VC + RA K + K+I+ + E + L +VN +V L Sbjct: 16 VVGRGAFGVVCKAKWRA-------KDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLY 68 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGN-----PGFEEERALFYAAEILCGLEDLHR- 304 A + +CLV+ GG L YN+ + P + A+ + + G+ LH Sbjct: 69 GA--CLNPVCLVMEYAEGGSL----YNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 305 --ENTVYRDLKPENILLDDYGHI-RISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 + ++RDLKP N+LL G + +I D G A I + G+ +MAPEV Sbjct: 123 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH--MTNNKGSAAWMAPEVFEGSN 180 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPF 385 Y D + G +++E+I + PF Sbjct: 181 YSEKCDVFSWGIILWEVITRRKPF 204 >4AU8-A nrPDB Length = 296 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 9/198 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G +G V + R T ++ A KR+ S AL E +L+++ + +V L Sbjct: 14 IGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKHKNIVRLHD 72 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 + L LV + DLK + ++ N + E + ++L GL H N ++RD Sbjct: 73 VLHSDKKLTLVFEFCDQ-DLKKY-FDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRD 130 Query: 312 LKPENILLDDYGHIRISDLGLAVKIPEGDLIR---GRVGTVGYMAPEVLNNQR-YGLSPD 367 LKP+N+L++ G ++++D GLA G +R V T+ Y P+VL + Y S D Sbjct: 131 LKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 188 Query: 368 YWGLGCLIYEMIEGQSPF 385 W GC+ E+ P Sbjct: 189 MWSAGCIFAELANAGRPL 206 >4UYA-A nrPDB Length = 340 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 93/208 (44%), Gaps = 16/208 (7%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 ++G GGFG+V + R + ++ ES+ E ++ + ++ L Sbjct: 33 LIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVR-REARLFAMLRHPNIIELR 91 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV-- 308 + LCLVL GG L + P + +A +I G+ LH E V Sbjct: 92 GVCLQQPHLCLVLEFARGGALNRALAGRRIP---PHVLVNWAVQIARGMLYLHEEAFVPI 148 Query: 309 -YRDLKPENILL------DDYGH--IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 +RDLK NILL DD + ++I+D GLA + + G +MAPEV+ + Sbjct: 149 LHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKM-ATAGAYAWMAPEVIKS 207 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 + D W G L++E++ G+ P+RG Sbjct: 208 SLFSKGSDIWSYGVLLWELLTGEVPYRG 235 >5UIU-A nrPDB Length = 323 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 103/229 (44%), Gaps = 25/229 (10%) Query: 169 RFLQWKWLERQPVTKNTFRQYRV------LGKGGFGEVCACQVR----ATGKMYACKRLE 218 RF + + E + VT N F + + +G+GGFG V V A K+ A + Sbjct: 27 RFHSFSFYELKNVTNN-FDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDIT 85 Query: 219 KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM 278 + +K++ + E +++ K + +V L D LCLV M G L + + Sbjct: 86 TEELKQQFDQ-----EIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCL 140 Query: 279 -GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA---V 334 G P A G+ LH + ++RD+K NILLD+ +ISD GLA Sbjct: 141 DGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASE 200 Query: 335 KIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSP--DYWGLGCLIYEMIEG 381 K + + VGT YMAPE L R ++P D + G ++ E+I G Sbjct: 201 KFAQTVMTSRIVGTTAYMAPEAL---RGEITPKSDIYSFGVVLLEIITG 246 >6F3F-A nrPDB Length = 455 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 107/226 (47%), Gaps = 17/226 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA----LNEKQ 236 + + + R LG+G FGEV T ++ IK K +M+ L E Q Sbjct: 184 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRV---------AIKTLKPGTMSPEAFLQEAQ 234 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +++K+ + +V L YA +++ + +V MN G L + + + +A+I Sbjct: 235 VMKKLRHEKLVQL-YAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIA 293 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMAP 354 G+ + R N V+RDL+ NIL+ + +++D GLA I + + +G + + AP Sbjct: 294 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 353 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEM-IEGQSPFRGRKEKVKREEVDR 399 E R+ + D W G L+ E+ +G+ P+ G + ++V+R Sbjct: 354 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 399 >5HIE-A nrPDB Length = 302 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 91/200 (45%), Gaps = 17/200 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G FG V + A K L ++++ K NE +L K ++ L Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFK------NEVGVLRKTRHVNIL-LFM 93 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 Y TK L +V G L H++ + FE + + A + G++ LH ++ ++RD Sbjct: 94 GYSTKPQLAIVTQWCEGSSLYHHLHII-ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRD 152 Query: 312 LKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMAPEVLNNQR---YGLS 365 LK NI L + ++I D GLA + G++ +MAPEV+ Q Y Sbjct: 153 LKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQ 212 Query: 366 PDYWGLGCLIYEMIEGQSPF 385 D + G ++YE++ GQ P+ Sbjct: 213 SDVYAFGIVLYELMTGQLPY 232 >6CQF-A nrPDB Length = 297 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 95/202 (47%), Gaps = 17/202 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG G +GEV + + +G + A K +K + ++ +K+IL + +AY Sbjct: 24 LGGGTYGEVFKARDKVSGDLVALKM-----VKMEPDDDVSTLQKEILILKTCRHANIVAY 78 Query: 252 --AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 +Y L + + G L+ IY + E + + E+L GL LH + ++ Sbjct: 79 HGSYLWLQKLWICMEFCGAGSLQ-DIYQV-TGSLSELQISYVCREVLQGLAYLHSQKKIH 136 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG---YMAPEVLN---NQRYG 363 RD+K NIL++D G +R++D G++ +I G + R+ +G +MAPEV Y Sbjct: 137 RDIKGANILINDAGEVRLADFGISAQI--GATLARRLAFIGTPYWMAPEVAAVALKGGYN 194 Query: 364 LSPDYWGLGCLIYEMIEGQSPF 385 D W LG E+ E Q P Sbjct: 195 ELCDIWSLGITAIELAELQPPL 216 >3CJF-A nrPDB Length = 309 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/232 (27%), Positives = 106/232 (45%), Gaps = 24/232 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGES---MALNEKQILEKVNSQF-VV 247 LG+G FG+V K C+ + K +K+ S ++E +IL + VV Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVV 94 Query: 248 NLAYA-YETKDALCLVLTIMNGGDLKFHIYNMGN----------PGFEEERALFYAAEIL 296 NL A + L +++ G+L ++ + N E + Y+ ++ Sbjct: 95 NLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVA 154 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIR---GRVGTVGYM 352 G+E L ++RDL NILL + ++I D GLA I + D +R R+ + +M Sbjct: 155 KGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARL-PLKWM 213 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLE 403 APE + ++ Y + D W G L++E+ G SP+ G K EE RR+ E Sbjct: 214 APETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKID---EEFCRRLKE 262 >3MIA-A nrPDB Length = 351 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 100/214 (46%), Gaps = 17/214 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G FGEV + R TG+ A K++ + +K AL E +IL+ + + VVNL Sbjct: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHENVVNLIE 83 Query: 252 AYETK--------DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 TK ++ LV DL + N+ F +L GL +H Sbjct: 84 ICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVL-VKFTLSEIKRVMQMLLNGLYYIH 141 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLA-----VKIPEGDLIRGRVGTVGYMAPEVLN 358 R ++RD+K N+L+ G ++++D GLA K + + RV T+ Y PE+L Sbjct: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 Query: 359 NQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEK 391 +R YG D WG GC++ EM +G E+ Sbjct: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 >2H8H-A nrPDB Length = 535 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 105/223 (47%), Gaps = 11/223 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA-LNEKQILE 239 + + + R LG+G FGEV G R+ K +K A L E Q+++ Sbjct: 264 IPRESLRLEVKLGQGCFGEVW------MGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 317 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 K+ + +V L YA +++ + +V M+ G L + + + AA+I G+ Sbjct: 318 KLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 376 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMAPEVL 357 + R N V+RDL+ NIL+ + +++D GLA I + + +G + + APE Sbjct: 377 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 436 Query: 358 NNQRYGLSPDYWGLGCLIYEM-IEGQSPFRGRKEKVKREEVDR 399 R+ + D W G L+ E+ +G+ P+ G + ++V+R Sbjct: 437 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 479 >5AMN-A nrPDB Length = 299 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 99/214 (46%), Gaps = 17/214 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA---LNEKQILEKVNSQFV 246 + LG+G FG+V + K +K+ S L+E +L++VN V Sbjct: 29 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHV 88 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALF------YAAEILCG 298 + L A L L++ G L+ + PG+ +ERAL +A +I G Sbjct: 89 IKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQISQG 148 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI----RGRVGTVGYMAP 354 ++ L V+RDL NIL+ + ++ISD GL+ + E D +GR+ V +MA Sbjct: 149 MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRI-PVKWMAI 207 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 E L + Y D W G L++E++ G +P+ G Sbjct: 208 ESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 241 >2WO6-A nrPDB Length = 382 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 28/229 (12%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN 233 KW++R + ++GKG FG+V R + A K ++ K+ + + Sbjct: 51 KWMDRYEIDS-------LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI---- 99 Query: 234 EKQILEKVNSQ------FVVNLAYAYETKDALCLVLTIM--NGGDLKFHIYNMGNPGFEE 285 E ++LE +N ++V+L + ++ LCLV ++ N DL + N G Sbjct: 100 EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL---LRNTNFRGVSL 156 Query: 286 ERALFYAAEILCGLEDLHRE--NTVYRDLKPENILLDD--YGHIRISDLGLAVKIPEGDL 341 +A ++ L L + ++ DLKPENILL + I+I D G + ++ G Sbjct: 157 NLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQR 214 Query: 342 IRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390 I + + Y +PEVL Y L+ D W LGC++ EM G+ F G E Sbjct: 215 IYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANE 263 >3QUP-A nrPDB Length = 323 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/245 (28%), Positives = 110/245 (44%), Gaps = 23/245 (9%) Query: 162 LDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY---ACKRLE 218 LDS+ L+ K LE + + F R+LGKG FG V Q++ + A K L+ Sbjct: 2 LDSLGISDELKEK-LEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLK 60 Query: 219 KKRIKKRKGESMALNEKQILEKVNSQFV---VNLAYAYETKDAL---CLVLTIMNGGDLK 272 I E L E +++ + V V ++ K L ++L M GDL Sbjct: 61 ADIIASSDIEEF-LREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDL- 118 Query: 273 FHIYNMG-----NP-GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIR 326 H + + NP + + + +I CG+E L N ++RDL N +L + + Sbjct: 119 -HAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVC 177 Query: 327 ISDLGLAVKIPEGDLIRGRVGT---VGYMAPEVLNNQRYGLSPDYWGLGCLIYE-MIEGQ 382 ++D GL+ KI GD R + V ++A E L + Y + D W G ++E M GQ Sbjct: 178 VADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQ 237 Query: 383 SPFRG 387 +P+ G Sbjct: 238 TPYAG 242 >3OMV-A nrPDB Length = 307 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 45/159 (28%), Positives = 79/159 (49%), Gaps = 8/159 (5%) Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 NE +L K ++ L Y TKD L +V G L H++ + F+ + + A Sbjct: 81 NEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLH-VQETKFQMFQLIDIA 138 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTV 349 + G++ LH +N ++RD+K NI L + ++I D GLA + + G+V Sbjct: 139 RQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSV 198 Query: 350 GYMAPEVL---NNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 +MAPEV+ +N + D + G ++YE++ G+ P+ Sbjct: 199 LWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPY 237 >4NEU-A nrPDB Length = 333 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 102/218 (46%), Gaps = 24/218 (11%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F + L GGFG+V C R G M K + K E++ L E +++ ++ Sbjct: 26 FLESAELDSGGFGKVSLCFHRTQGLMIM-KTVYKGPNCIEHNEAL-LEEAKMMNRLRHSR 83 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYN--MGNPGFEEERALFYAAEILCGLEDLH 303 VV L + LV+ M G+L H+ M P + R + EI+ G+ LH Sbjct: 84 VVKLLGVIIEEGKYSLVMEYMEKGNL-MHVLKAEMSTPLSVKGRIIL---EIIEGMCYLH 139 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAV-------------KIPEGD-LIRGRVGTV 349 + +++DLKPENIL+D+ HI+I+DLGLA ++ E D + GT+ Sbjct: 140 GKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTL 199 Query: 350 GYMAPEVLN--NQRYGLSPDYWGLGCLIYEMIEGQSPF 385 YMAPE LN N + D + +++ + + P+ Sbjct: 200 YYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY 237 >3UIM-A nrPDB Length = 326 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 97/212 (45%), Gaps = 10/212 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V + F +LG+GGFG+V ++ A G + A KRL+++R + GE E +++ Sbjct: 27 VASDNFSNKNILGRGGFGKVYKGRL-ADGTLVAVKRLKEERTQG--GELQFQTEVEMISM 83 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM--GNPGFE---EERALFYAAEI 295 + ++ L T LV M G + + P + +R +A Sbjct: 84 AVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARG 143 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD--LIRGRVGTVGYMA 353 L L D ++RD+K NILLD+ + D GLA + D + GT+G++A Sbjct: 144 LAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIA 203 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 PE L+ + D +G G ++ E+I GQ F Sbjct: 204 PEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >3HMP-A nrPDB Length = 342 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 69/284 (24%), Positives = 125/284 (44%), Gaps = 31/284 (10%) Query: 187 RQYRVL---GKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-- 241 R Y +L G GG +V + ++YA K + + + +S NE L K+ Sbjct: 56 RIYSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYR-NEIAYLNKLQQ 113 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +S ++ L Y YE D + +M G++ + + + Y +L + Sbjct: 114 HSDKIIRL-YDYEITDQY--IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLI--RGRVGTVGYMAPEVLN 358 +H+ V+ DLKP N L+ D G +++ D G+A ++ P+ + +VGTV YM PE + Sbjct: 171 IHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 229 Query: 359 NQRYG-----------LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 + D W LGC++Y M G++PF+ ++ + + + E+ Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISK--LHAIIDPNHEI 287 Query: 408 YSHKFSE-EAKSICKMLLTKDAKQRLGCQEEGA---AEVKRHPF 447 E + + + K L +D KQR+ E A +++ HP Sbjct: 288 EFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 331 >2BUJ-A nrPDB Length = 317 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 94/213 (44%), Gaps = 22/213 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+GGF V + G YA KR+ + R+ + ++ N +V AY Sbjct: 37 LGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLV--AY 94 Query: 252 AYETKDA---LCLVLTIMNGGDLKFHIYNMGNPG--FEEERALFYAAEILCGLEDLHREN 306 + A L+L G L I + + G E++ L+ I GLE +H + Sbjct: 95 CLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKG 154 Query: 307 TVYRDLKPENILLDDYGHIRISDLG---LAVKIPEG--------DLIRGRVGTVGYMAPE 355 +RDLKP NILL D G + DLG A EG D R T+ Y APE Sbjct: 155 YAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRC-TISYRAPE 213 Query: 356 VLNNQRYGL---SPDYWGLGCLIYEMIEGQSPF 385 + + Q + + D W LGC++Y M+ G+ P+ Sbjct: 214 LFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY 246 >5AP3-A nrPDB Length = 313 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 67/292 (22%), Positives = 127/292 (43%), Gaps = 28/292 (9%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNE 234 + + V + + +G GG +V + ++YA K + + + +S NE Sbjct: 19 YFQSMSVKGRIYSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYR-NE 76 Query: 235 KQILEKV--NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 L K+ +S ++ L Y YE D + +M G++ + + + Y Sbjct: 77 IAYLNKLQQHSDKIIRL-YDYEITDQY--IYMVMECGNIDLNGWLKKKKSIDPWERKSYW 133 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLI--RGRVGTV 349 +L + +H+ V+ DLKP N L+ D G +++ D G+A ++ P+ + +VGTV Sbjct: 134 KNMLEAVHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTV 192 Query: 350 GYMAPEVLNNQRYG-----------LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD 398 YM PE + + D W LGC++Y M G++PF+ ++ + + Sbjct: 193 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISK--LH 250 Query: 399 RRVLETEEVYSHKFSE-EAKSICKMLLTKDAKQRLGCQEEGA---AEVKRHP 446 + E+ E + + + K L +D KQR+ E A +++ HP Sbjct: 251 AIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 302 >4IC8-A nrPDB Length = 442 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 101/223 (45%), Gaps = 19/223 (8%) Query: 181 VTKNTFRQYRVL---GKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI 237 VT + +Y ++ G G +G V + + R TG+ A K++ L E +I Sbjct: 49 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNA-FDVVTNAKRTLRELKI 107 Query: 238 LEKVNSQFVVNL------AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 L+ ++ + Y ++ +VL +M DL I++ E R Y Sbjct: 108 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLY 166 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-----LIRGRV 346 ++L GL+ +H ++RDLKP N+L+++ ++I D G+A + + V Sbjct: 167 --QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYV 224 Query: 347 GTVGYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 T Y APE+ L+ Y + D W +GC+ EM+ + F G+ Sbjct: 225 ATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGK 267 >6DBM-A nrPDB Length = 318 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 104/218 (47%), Gaps = 23/218 (10%) Query: 183 KNTFRQYRVLGKGGFGEV---CACQVR-ATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 K ++ R LG+G FG+V C TG+M A K L+ + + S E IL Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHR--SGWKQEIDIL 87 Query: 239 EKVNSQFVVNLAYAYETKDA--LCLVLTIMNGGDLKFHI--YNMGNPGFEEERALFYAAE 294 + + ++ E A L LV+ + G L+ ++ +++G + L +A + Sbjct: 88 RTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGL-----AQLLLFAQQ 142 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRV---GTVG 350 I G+ LH ++ ++RDL N+LLD+ ++I D GLA +PEG + R R V Sbjct: 143 ICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 202 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMI----EGQSP 384 + APE L ++ + D W G +YE++ QSP Sbjct: 203 WYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSP 240 >4ZSG-A nrPDB Length = 347 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 95/209 (45%), Gaps = 16/209 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL-- 249 +G G +G V + + R TG+ A K++ L E +IL+ ++ + Sbjct: 15 IGNGAYGVVSSARRRLTGQQVAIKKIPNA-FDVVTNAKRTLRELKILKHFKHDNIIAIKD 73 Query: 250 ----AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 Y ++ +VL +M DL I++ E R Y ++L GL+ +H Sbjct: 74 ILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLY--QLLRGLKYMHSA 130 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-----LIRGRVGTVGYMAPEV-LNN 359 ++RDLKP N+L+++ ++I D G+A + + V T Y APE+ L+ Sbjct: 131 QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSL 190 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 Y + D W +GC+ EM+ + F G+ Sbjct: 191 HEYTQAIDLWSVGCIFGEMLARRQLFPGK 219 >3DLS-A nrPDB Length = 335 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 98/209 (46%), Gaps = 9/209 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKR------IKKRKGESMALNEKQILEKVNSQF 245 LG G FG V + K K ++K++ I+ K + L E IL +V Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTL-EIAILSRVEHAN 90 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++ + +E + LV+ +G L + +P +E A + +++ + L + Sbjct: 91 IIKVLDIFENQGFFQLVME-KHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLK 149 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GL 364 + ++RD+K ENI++ + I++ D G A + G L GT+ Y APEVL Y G Sbjct: 150 DIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGP 209 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVK 393 + W LG +Y ++ ++PF +E V+ Sbjct: 210 ELEMWSLGVTLYTLVFEENPFCELEETVE 238 >5SYS-A nrPDB Length = 286 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 106/223 (47%), Gaps = 11/223 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA-LNEKQILE 239 + + + R LG+G FGE C + G R+ K +K A L E Q+++ Sbjct: 15 IPRESLRLEVKLGQGCFGE---CWM---GTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 68 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 K+ + +V L YA +++ + +V M+ G L + + + AA+I G+ Sbjct: 69 KLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM 127 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMAPEVL 357 + R N V+RDL+ NIL+ + +++D GLA I + + +G + + APE Sbjct: 128 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 187 Query: 358 NNQRYGLSPDYWGLGCLIYEM-IEGQSPFRGRKEKVKREEVDR 399 R+ + D W G L+ E+ +G+ P+ G + ++V+R Sbjct: 188 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 230 >2H34-A nrPDB Length = 309 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 100/220 (45%), Gaps = 8/220 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 +R R++G+GG G+V + ++ A K + + + E + ++ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 VV + E L + + ++NG DL + G RA+ +I L+ H Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGP--LAPPRAVAIVRQIGSALDAAHAA 153 Query: 306 NTVYRDLKPENILL--DDYGHIRISDLGLAVKIPEGDLIR--GRVGTVGYMAPEVLNNQR 361 +RD+KPENIL+ DD+ ++ D G+A + L + VGT+ YMAPE + Sbjct: 154 GATHRDVKPENILVSADDFAYL--VDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESH 211 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV 401 D + L C++YE + G P++G + V +++ + Sbjct: 212 ATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAI 251 >6FER-A nrPDB Length = 309 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 94/213 (44%), Gaps = 29/213 (13%) Query: 192 LGKGGFGEVCACQVRATGK----------------MYACKRLEKKRIKKRKGESMALNEK 235 LG+G FGEV C+V K + A K L K + + L E Sbjct: 17 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARND--FLKEI 74 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI--YNMGNPGFEEERAL---- 289 +I+ ++ +++L T D LC++ M GDL + + N + R + Sbjct: 75 KIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTN 134 Query: 290 --FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL--IRGR 345 F A +I G++ L N V+RDL N L+ I+I+D G++ + GD I+GR Sbjct: 135 LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGR 194 Query: 346 -VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYE 377 V + +M+ E + ++ + D W G ++E Sbjct: 195 AVLPIRWMSWESILLGKFTTASDVWAFGVTLWE 227 >6HMD-A nrPDB Length = 365 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/225 (27%), Positives = 91/225 (40%), Gaps = 46/225 (20%) Query: 260 CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL 319 LV +N D K +Y + + FY E+L L+ H + ++RD+KP N+++ Sbjct: 126 ALVFEYINNTDFK-QLYQI----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMI 180 Query: 320 D-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYE 377 D +R+ D GLA RV + + PE+L + Q Y S D W LGC++ Sbjct: 181 DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 240 Query: 378 MIEGQSPFRGRKEKVKREEVDRRVLETEEVYS---------------------------- 409 MI + PF ++ + +VL TEE+Y Sbjct: 241 MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF 300 Query: 410 ------HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 H S EA + LL D +QRL A E HP+F Sbjct: 301 IHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKEAMEHPYF 340 >5VO2-A nrPDB Length = 300 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 43/192 (22%), Positives = 84/192 (43%), Gaps = 4/192 (2%) Query: 197 FGEVCACQVRATGKMYAC--KRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYE 254 F E+ Q +G A R + + +K + + + L K+ ++ Sbjct: 11 FEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCT 70 Query: 255 TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKP 314 C+++ G L + + G P + ++ I G+ LH ++RDLK Sbjct: 71 QAPCYCILMEFCAQGQL-YEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKS 128 Query: 315 ENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCL 374 N+L+ ++ISD G + ++ + GTV +MAPEV+ N+ D W G + Sbjct: 129 PNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVV 188 Query: 375 IYEMIEGQSPFR 386 ++E++ G+ P++ Sbjct: 189 LWELLTGEIPYK 200 >4YFF-A nrPDB Length = 311 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 95/207 (45%), Gaps = 9/207 (4%) Query: 189 YRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVN 248 + ++G G FG+V + R K+ A KR + M E IL ++N V+ Sbjct: 47 HEIIGSGSFGKVY--KGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQ 104 Query: 249 LAYA-YETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR--E 305 A +V ++GG L F + + + + L A ++ G+E LH + Sbjct: 105 FVGACLNDPSQFAIVTQYISGGSL-FSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQ 163 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLA--VKIPEGDLIRGRVGTVGYMAPEVLNN-QRY 362 ++RDL NILL + GH ++D G + ++ + D + + G + +MAPEV RY Sbjct: 164 PIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRY 223 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRK 389 + D + ++E++ G+ PF K Sbjct: 224 TIKADVFSYALCLWEILTGEIPFAHLK 250 >6FEX-A nrPDB Length = 321 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 92/218 (42%), Gaps = 32/218 (14%) Query: 192 LGKGGFGEVCACQV----------------RATGKMYACKRLEKKRIKKRKGESMALNEK 235 LG+G FGEV C+V + + A K L K + + L E Sbjct: 24 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDF--LKEV 81 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM-----------GNPGFE 284 +I+ ++ ++ L D LC++ M GDL + G+P Sbjct: 82 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDPTIS 141 Query: 285 EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR- 343 L AA+I G+ L N V+RDL N L+ + I+I+D G++ + GD R Sbjct: 142 YPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV 201 Query: 344 -GR-VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMI 379 GR V + +MA E + ++ + D W G ++E++ Sbjct: 202 QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 239 >3I81-A nrPDB Length = 315 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 62/240 (25%), Positives = 105/240 (43%), Gaps = 23/240 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA-----LNEK 235 V + R LG+G FG V + K R+ K + + SM LNE Sbjct: 15 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNE--AASMRERIEFLNEA 72 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM-----GNPGFEE---ER 287 ++++ N VV L +++ +M GDLK ++ ++ NP + Sbjct: 73 SVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSK 132 Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRV 346 + A EI G+ L+ V+RDL N ++ + ++I D G+ I E D R G Sbjct: 133 MIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGK 192 Query: 347 GT--VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLE 403 G V +M+PE L + + D W G +++E+ + P++G + E+V R V+E Sbjct: 193 GLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQG----LSNEQVLRFVME 248 >6EII-A nrPDB Length = 352 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 45/146 (30%), Positives = 76/146 (52%), Gaps = 4/146 (2%) Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGT 348 FY EIL L+ H ++RD+KP N+++D ++ +R+ D GLA G RV + Sbjct: 158 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 217 Query: 349 VGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 + PE+L + Q Y S D W LGC++ MI + PF + + +VL TE++ Sbjct: 218 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 277 Query: 408 YSH--KFSEEAKSICKMLLTKDAKQR 431 Y + K++ E +L + +++R Sbjct: 278 YDYIDKYNIELDPRFNDILGRHSRKR 303 >4MD7-E nrPDB Length = 391 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 45/146 (30%), Positives = 76/146 (52%), Gaps = 4/146 (2%) Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGT 348 FY EIL L+ H ++RD+KP N+++D ++ +R+ D GLA G RV + Sbjct: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 Query: 349 VGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 + PE+L + Q Y S D W LGC++ MI + PF + + +VL TE++ Sbjct: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 Query: 408 YSH--KFSEEAKSICKMLLTKDAKQR 431 Y + K++ E +L + +++R Sbjct: 255 YDYIDKYNIELDPRFNDILGRHSRKR 280 >3A4O-X nrPDB Length = 286 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 105/214 (49%), Gaps = 14/214 (6%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + + + + + LG G FGEV + K+ A K L+ + + L E +++ Sbjct: 10 IPRESIKLVKRLGAGQFGEVWMGYYNNSTKV-AVKTLKPGTMSVQA----FLEEANLMKT 64 Query: 241 VNSQFVVNLAYAYETKDALCLVLT--IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + +V L YA T++ ++T + G L F + G + + ++A+I G Sbjct: 65 LQHDKLVRL-YAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLP-KLIDFSAQIAEG 122 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGYMAPE 355 + + R+N ++RDL+ N+L+ + +I+D GLA ++ E + R G + + APE Sbjct: 123 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLA-RVIEDNEYTAREGAKFPIKWTAPE 181 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGR 388 +N + + D W G L+YE++ G+ P+ GR Sbjct: 182 AINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 215 >5WNO-A nrPDB Length = 330 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 37/121 (30%), Positives = 63/121 (52%), Gaps = 9/121 (7%) Query: 271 LKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDL 330 LK H N+G + Y +I G++ L ++ V+RDL N+L+ + H+ I+D Sbjct: 114 LKLHKENLG-----AREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDF 168 Query: 331 GLA-VKIPEGDLIRGRVGTVG--YMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFR 386 GL+ + + D I + G V ++A E+ + Y + D W G +E+I GQSP++ Sbjct: 169 GLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQ 228 Query: 387 G 387 G Sbjct: 229 G 229 >2ZMD-A nrPDB Length = 390 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 68/284 (23%), Positives = 124/284 (43%), Gaps = 31/284 (10%) Query: 187 RQYRVL---GKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-- 241 R Y +L G GG +V + ++YA K + + + +S NE L K+ Sbjct: 56 RIYSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYR-NEIAYLNKLQQ 113 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +S ++ L Y YE D + +M G++ + + + Y +L + Sbjct: 114 HSDKIIRL-YDYEITDQY--IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLI--RGRVGTVGYMAPEVLN 358 +H+ V+ DLKP N L+ D G +++ D G+A ++ P+ + +VG V YM PE + Sbjct: 171 IHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIK 229 Query: 359 NQRYG-----------LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 + D W LGC++Y M G++PF+ ++ + + + E+ Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISK--LHAIIDPNHEI 287 Query: 408 YSHKFSE-EAKSICKMLLTKDAKQRLGCQEEGA---AEVKRHPF 447 E + + + K L +D KQR+ E A +++ HP Sbjct: 288 EFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV 331 >2XYN-A nrPDB Length = 292 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 52/229 (22%), Positives = 102/229 (44%), Gaps = 15/229 (6%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F +W+ +ER +T LG G +GEV + A K L++ + Sbjct: 17 ENLYFQSMDKWE-MERTDITMK-----HKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM 70 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 + + L E +++++ +V L + +V M G+L ++ Sbjct: 71 EVEE----FLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 126 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI 342 L+ A +I +E L ++N ++RDL N L+ + ++++D GL+ ++ GD Sbjct: 127 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLS-RLMTGDTY 185 Query: 343 RGRVGT---VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 G + + APE L + + D W G L++E+ G SP+ G Sbjct: 186 TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 234 >4OLI-A nrPDB Length = 645 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 105/218 (48%), Gaps = 23/218 (10%) Query: 183 KNTFRQYRVLGKGGFGEV---CACQVR-ATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 K ++ R LG+G FG+V C TG+M A K L+ + + S E IL Sbjct: 352 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHR--SGWKQEIDIL 409 Query: 239 EKVNSQFVVNLAYAYETK--DALCLVLTIMNGGDLKFHI--YNMGNPGFEEERALFYAAE 294 + + ++ E + +L LV+ + G L+ ++ +++G + L +A + Sbjct: 410 RTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIG-----LAQLLLFAQQ 464 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRV---GTVG 350 I G+ LH ++ ++R+L N+LLD+ ++I D GLA +PEG + R R V Sbjct: 465 ICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 524 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMI----EGQSP 384 + APE L ++ + D W G +YE++ QSP Sbjct: 525 WYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSP 562 >5XVU-A nrPDB Length = 332 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 46/152 (30%), Positives = 75/152 (49%), Gaps = 7/152 (4%) Query: 261 LVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLD 320 L+ +N D K P F ++ +Y +IL L+ H + ++RD+KP NI++D Sbjct: 105 LIFEYINNIDFK-----TLYPKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMID 159 Query: 321 -DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEM 378 + IR+ GLA G RV + Y PE+L + Q Y S D W LGC++ M Sbjct: 160 HENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGM 219 Query: 379 IEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 I + PF + + +VL TE+++++ Sbjct: 220 IFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAY 251 >1U59-A nrPDB Length = 287 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 101/209 (48%), Gaps = 19/209 (9%) Query: 192 LGKGGFGEVCACQVRATGKMY-ACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 LG G FG V R K ++ K+ +K E M + E QI+ ++++ ++V L Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRLI 76 Query: 251 YAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEIL----CGLEDLHRE 305 + +AL LV+ + GG L KF + G EE + AE+L G++ L + Sbjct: 77 GVCQA-EALMLVMEMAGGGPLHKFLV------GKREEIPVSNVAELLHQVSMGMKYLEEK 129 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVG---TVGYMAPEVLNNQR 361 N V+RDL N+LL + + +ISD GL+ + D R + + APE +N ++ Sbjct: 130 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 189 Query: 362 YGLSPDYWGLGCLIYEMIE-GQSPFRGRK 389 + D W G ++E + GQ P++ K Sbjct: 190 FSSRSDVWSYGVTMWEALSYGQKPYKKMK 218 >4XEY-B nrPDB Length = 408 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 97/219 (44%), Gaps = 15/219 (6%) Query: 174 KW-LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMAL 232 KW +ER +T LG G +GEV + A K L++ ++ + L Sbjct: 119 KWEMERTDITMK-----HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE----FL 169 Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 E +++++ +V L + ++ M G+L ++ L+ A Sbjct: 170 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 229 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---V 349 +I +E L ++N ++RDL N L+ + ++++D GL+ ++ GD G + Sbjct: 230 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLS-RLMTGDTYTAHAGAKFPI 288 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 + APE L ++ + D W G L++E+ G SP+ G Sbjct: 289 KWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 327 >5EG3-A nrPDB Length = 334 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 103/223 (46%), Gaps = 30/223 (13%) Query: 192 LGKGGFGEVCACQVRATGK-------MYACKRLEKKRIKKRKGESMALNEKQILEKVNS- 243 LG+G FG+V + K A K L+ +K + ++E ++++ + Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSD--LVSEMEMMKMIGKH 100 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE---------EERALFY--- 291 + ++NL A L +++ + G+L+ ++ PG E EE+ F Sbjct: 101 KNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLV 160 Query: 292 --AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GR 345 ++ G+E L + ++RDL N+L+ + ++I+D GLA I D + GR Sbjct: 161 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTNGR 220 Query: 346 VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 + V +MAPE L ++ Y D W G L++E+ G SP+ G Sbjct: 221 L-PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 262 >3ORP-A nrPDB Length = 311 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 93/217 (42%), Gaps = 34/217 (15%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKK---------RIKKRKGESMALNEKQILEKV 241 +LG GG EV + + A K L R ++ + ALN I+ Sbjct: 19 ILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVA-- 76 Query: 242 NSQFVVNLAYAYETKDALC-------LVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 Y+T +A +V+ ++G L+ ++ G +RA+ A+ Sbjct: 77 ----------VYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGP--MTPKRAIEVIAD 124 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE-GDLIR---GRVGTVG 350 L H+ ++RD+KP NI++ +++ D G+A I + G+ + +GT Sbjct: 125 ACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQ 184 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 Y++PE D + LGC++YE++ G+ PF G Sbjct: 185 YLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG 221 >2HK5-A nrPDB Length = 270 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 100/215 (46%), Gaps = 19/215 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA----LNEKQ 236 + + + + + LG G FGEV M + K +K K SM+ L E Sbjct: 12 IPRESLKLEKKLGAGQFGEVW---------MATYNKHTKVAVKTMKPGSMSVEAFLAEAN 62 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +++ + +V L +A TK+ + ++ M G L + + + + ++A+I Sbjct: 63 VMKTLQHDKLVKL-HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIA 121 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGYMA 353 G+ + + N ++RDL+ NIL+ +I+D GLA ++ E + R G + + A Sbjct: 122 EGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLA-RVIEDNEYTAREGAKFPIKWTA 180 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 PE +N + + D W G L+ E++ G+ P+ G Sbjct: 181 PEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 215 >6NPU-A nrPDB Length = 298 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 97/219 (44%), Gaps = 15/219 (6%) Query: 174 KW-LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMAL 232 KW +ER +T LG G +GEV + A K L++ ++ + L Sbjct: 20 KWEMERTDITMK-----HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE----FL 70 Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 E +++++ +V L + ++ M G+L ++ L+ A Sbjct: 71 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 130 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---V 349 +I +E L ++N ++RDL N L+ + ++++D GL+ ++ GD G + Sbjct: 131 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLS-RLMTGDTYTAHAGAKFPI 189 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 + APE L ++ + D W G L++E+ G SP+ G Sbjct: 190 KWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 228 >1FVR-A nrPDB Length = 327 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 101/220 (45%), Gaps = 30/220 (13%) Query: 191 VLGKGGFGEVCACQVRATG-KMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ-FVVN 248 V+G+G FG+V +++ G +M A + K+ K A E ++L K+ ++N Sbjct: 32 VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFA-GELEVLCKLGHHPNIIN 90 Query: 249 LAYAYETKDALCLVLTIMNGGDL--------------KFHIYNMGNPGFEEERALFYAAE 294 L A E + L L + G+L F I N ++ L +AA+ Sbjct: 91 LLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAAD 150 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA------VKIPEGDLIRGRVGT 348 + G++ L ++ ++RDL NIL+ + +I+D GL+ VK G L Sbjct: 151 VARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRL------P 204 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 V +MA E LN Y + D W G L++E++ G +P+ G Sbjct: 205 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG 244 >4M7I-A nrPDB Length = 299 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 71/297 (23%), Positives = 126/297 (42%), Gaps = 44/297 (14%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRK-GESMALNEKQILEKVNSQ 244 F + LG+GGFG V + + YA KR+ R+ R+ + E + L K+ Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRI---RLPNRELAREKVMREVKALAKLEHP 63 Query: 245 FVVNLAYAYETKDA------------LCLVLTIMNGGDLKFHIYNMGNPGFEE-ERA--L 289 +V A+ K+ L + + + +LK + G EE ER+ L Sbjct: 64 GIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLK--DWMNGRCTIEERERSVCL 121 Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI------------- 336 +I +E LH + ++RDLKP NI +++ D GL + Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 181 Query: 337 PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE 396 P G+VGT YM+PE ++ Y D + LG +++E++ PF + E+V R Sbjct: 182 PAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL---YPFSTQMERV-RTL 237 Query: 397 VDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNF 453 D R L+ +++ K+ C+ ++ +D + A + + F +++F Sbjct: 238 TDVRNLKFPPLFTQKYP------CEYVMVQDMLSPSPMERPEAINIIENAVFEDLDF 288 >2OZO-A nrPDB Length = 613 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 101/209 (48%), Gaps = 19/209 (9%) Query: 192 LGKGGFGEVCACQVRATGKMY-ACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 LG G FG V R K ++ K+ +K E M + E QI+ ++++ ++V L Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRLI 402 Query: 251 YAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEIL----CGLEDLHRE 305 + +AL LV+ + GG L KF + G EE + AE+L G++ L + Sbjct: 403 GVCQA-EALMLVMEMAGGGPLHKFLV------GKREEIPVSNVAELLHQVSMGMKYLEEK 455 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVG---TVGYMAPEVLNNQR 361 N V+R+L N+LL + + +ISD GL+ + D R + + APE +N ++ Sbjct: 456 NFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 Query: 362 YGLSPDYWGLGCLIYEMIE-GQSPFRGRK 389 + D W G ++E + GQ P++ K Sbjct: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMK 544 >3C1X-A nrPDB Length = 373 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 95/204 (46%), Gaps = 11/204 (5%) Query: 191 VLGKGGFGEVC-ACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 V+G+G FG V + GK C RI S L E I++ + V++L Sbjct: 96 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 155 Query: 250 -AYAYETKDALCLVLTIMNGGDLKFHIYN-MGNPGFEEERALFYAAEILCGLEDLHRENT 307 ++ + +VL M GDL+ I N NP ++ + + ++ G++ L + Sbjct: 156 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKD--LIGFGLQVAKGMKFLASKKF 213 Query: 308 VYRDLKPENILLDDYGHIRISDLGLAVKI--PEGDLIRGRVGT---VGYMAPEVLNNQRY 362 V+RDL N +LD+ ++++D GLA + E D + + G V +MA E L Q++ Sbjct: 214 VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKF 273 Query: 363 GLSPDYWGLGCLIYE-MIEGQSPF 385 D W G L++E M G P+ Sbjct: 274 TTKSDVWSFGVLLWELMTRGAPPY 297 >4IAN-A nrPDB Length = 358 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 100/220 (45%), Gaps = 30/220 (13%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRK-GESMALNEKQILEKVNSQ- 244 ++Y V G G G V + VRA A + + K I+ + + L E + L+K+N Sbjct: 30 KRYNVYGYTGQG-VFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDAD 88 Query: 245 -----FVVNLAYAYETKDALCLVLTIMN----------GGDLKFHIYNMGNPGFEEERAL 289 + L + K LCLV ++ G D+ HI + + Sbjct: 89 PDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRS--------- 139 Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI-RISDLGLAVKIPEGDLIRGRVGT 348 Y+ ++ L+ L R N ++ D+KP+NIL+++ I ++ D G A + + D+ V Sbjct: 140 -YSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSR 198 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 Y APE++ + Y D W +GC +YE+ G+ F G+ Sbjct: 199 F-YRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGK 237 >6O6Q-A nrPDB Length = 335 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 93/198 (46%), Gaps = 10/198 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R LG+G + EV + K L+ + KK K E L K +++ N ++++ Sbjct: 47 RKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIKREISIL--KNLVDGPNIIAMLDV 104 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 ++K L+ +N D + +Y P F + FY E+L L+ H ++ Sbjct: 105 VREPQSKTP-GLIFEHINNIDFR-SLY----PTFTDYDIRFYMYELLKALDYSHSMGIMH 158 Query: 310 RDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR-YGLSPD 367 RD+KP N+++D D +R+ D GLA G RV + + PE+L + R Y S D Sbjct: 159 RDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRLYDYSLD 218 Query: 368 YWGLGCLIYEMIEGQSPF 385 W GC++ M+ + PF Sbjct: 219 MWSFGCMLASMVFMKEPF 236 >4UY9-A nrPDB Length = 323 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 91/208 (43%), Gaps = 16/208 (7%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 ++G GGFG+V R + + E++ E ++ + ++ L Sbjct: 16 IIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVR-QEAKLFAMLKHPNIIALR 74 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV-- 308 + LCLV+ GG L + P + + +A +I G+ LH E V Sbjct: 75 GVCLKEPNLCLVMEFARGGPLNRVLSGKRIP---PDILVNWAVQIARGMNYLHDEAIVPI 131 Query: 309 -YRDLKPENILL------DDYGH--IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 +RDLK NIL+ D + ++I+D GLA + + GT +MAPEV+ Sbjct: 132 IHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWMAPEVIRA 190 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 + D W G L++E++ G+ PFRG Sbjct: 191 SMFSKGSDVWSYGVLLWELLTGEVPFRG 218 >4JLC-A nrPDB Length = 657 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 19/212 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 +LG+G V + + TG +YA K I + + + E ++L+K+N + +V L Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKL- 71 Query: 251 YAYE---TKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGLEDLHREN 306 +A E T L++ G L + N G E L +++ G+ L Sbjct: 72 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 131 Query: 307 TVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL----- 357 V+RD+KP NI+ D +++D G A ++ + + GT Y+ P++ Sbjct: 132 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 191 Query: 358 ---NNQRYGLSPDYWGLGCLIYEMIEGQSPFR 386 + ++YG + D W +G Y G PFR Sbjct: 192 RKDHQKKYGATVDLWSVGVTFYHAATGSLPFR 223 >4E7W-A nrPDB Length = 394 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 77/312 (24%), Positives = 126/312 (40%), Gaps = 49/312 (15%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 +V+G G FG V ++ + ++ K L+ KR K R E QI+ V VV+L Sbjct: 46 KVIGNGSFGVVFQAKLVESDEVAIKKVLQDKRFKNR--------ELQIMRIVKHPNVVDL 97 Query: 250 -AYAY---ETKDALCLVLTIMNGGDLKFHI---YNMGNPGFEEERALFYAAEILCGLEDL 302 A+ Y + KD + L L + + + Y Y ++L L + Sbjct: 98 KAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYI 157 Query: 303 HRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE-VLNNQ 360 H +RD+KP+N+LLD G +++ D G A + G+ + + Y APE + Sbjct: 158 HSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGAT 217 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGR-----------------KEKVKREEVDRRVLE 403 Y + D W GC++ E+++GQ F G +E++K + + Sbjct: 218 NYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHK 277 Query: 404 TEEVYSHKFSE--------EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNF-- 453 ++ H FS+ +A + LL RL A E HPFF + Sbjct: 278 FPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARL-----TAIEALCHPFFDELRTGE 332 Query: 454 KRLEAGMLDPPF 465 R+ G PP Sbjct: 333 ARMPNGRELPPL 344 >4PL5-B nrPDB Length = 435 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 63/194 (32%), Positives = 92/194 (47%), Gaps = 34/194 (17%) Query: 298 GLEDLHRENTVYRDLKPENILL---DDYGHIR--ISDLGLAVKIPEG----DLIRGRVGT 348 GL LH N V+RDLKP NILL + +G I+ ISD GL K+ G G GT Sbjct: 133 GLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGT 192 Query: 349 VGYMAPEVL-----NNQRYGLSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDRRVL 402 G++APE+L +N Y + D + GC+ Y +I EG PF K ++ + Sbjct: 193 EGWIAPEMLSEDCKDNPTYTV--DIFSAGCVFYYVISEGYHPF--GKSLQRQANILLGAC 248 Query: 403 ETEEVYSHKFSEE-AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF----RNMNF---- 453 + +S K + A+ + + ++ D +QR A V +HPFF + + F Sbjct: 249 NLDCFHSDKHEDVIARELIEKMIAMDPQQR-----PSAKHVLKHPFFWSLEKQLQFFQDV 303 Query: 454 -KRLEAGMLDPPFV 466 R+E LD P V Sbjct: 304 SDRIEKEALDGPIV 317 >5U6B-A nrPDB Length = 307 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 106/219 (48%), Gaps = 27/219 (12%) Query: 190 RVLGKGGFGEVCACQVRA----------TGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 + LG+G FG V Q+ T K+ C R E ++ E++ + E + Sbjct: 29 KTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSE---LEDFLSEAVCMKE---FD 82 Query: 240 KVNSQFVVNLAYA---YETKDALCLVLTIMNGGDL-KFHIYN-MGN-PGFEEERALF-YA 292 N ++ + + E+ A ++L M GDL F +Y+ +G+ P + + L + Sbjct: 83 HPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFM 142 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRVGT--V 349 A+I G+E L + ++RDL N +L++ + ++D GL+ KI GD R GR+ V Sbjct: 143 ADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPV 202 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEM-IEGQSPFRG 387 ++A E L ++ Y D W G ++E+ GQ+P+ G Sbjct: 203 KWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPG 241 >3E3P-A nrPDB Length = 360 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/234 (24%), Positives = 105/234 (44%), Gaps = 14/234 (5%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKR-LEKKRIKKRKGESMALNEK 235 ER + F+ R+ G+G FG V + ++TG A K+ ++ R + R+ + M + Sbjct: 16 ERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIM--QDL 73 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTI--------MNGGDLKFHIYNMGNPGFEEER 287 +L N + + Y +D + L + ++ ++ + P + Sbjct: 74 AVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKV 133 Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDY-GHIRISDLGLAVKIPEGDLIRGRV 346 LF + G L N +RD+KP N+L+++ G +++ D G A K+ + + Sbjct: 134 FLFQLIRSI-GCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYI 192 Query: 347 GTVGYMAPE-VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 + Y APE + NQ Y + D W +GC+ EM+ G+ FRG + E+ R Sbjct: 193 CSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVR 246 >1AD5-A nrPDB Length = 438 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 97/215 (45%), Gaps = 29/215 (13%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA----LNEKQ 236 + + + + + LG G FGEV M + K +K K SM+ L E Sbjct: 179 IPRESLKLEKKLGAGQFGEVW---------MATYNKHTKVAVKTMKPGSMSVEAFLAEAN 229 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +++ + +V L +A TK+ + ++ M G L + + + + ++A+I Sbjct: 230 VMKTLQHDKLVKL-HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIA 288 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGYMA 353 G+ + + N ++RDL+ NIL+ +I+D GLA RVG + + A Sbjct: 289 EGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLA-----------RVGAKFPIKWTA 337 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 PE +N + + D W G L+ E++ G+ P+ G Sbjct: 338 PEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 372 >2RIO-A nrPDB Length = 434 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 88/327 (26%), Positives = 134/327 (40%), Gaps = 61/327 (18%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 KN ++LG G G V Q G+ A KR+ +AL E ++L + + Sbjct: 14 KNLVVSEKILGYGSSGTV-VFQGSFQGRPVAVKRMLIDFC------DIALMEIKLLTESD 66 Query: 243 SQFVVNLAYAYETKD---ALCLVLTIMNGGDLKFHIYNMGNPGFE---EERALFYAAEIL 296 V Y ET D + L L +N DL N+ + + E + +I Sbjct: 67 DHPNVIRYYCSETTDRFLYIALELCNLNLQDL-VESKNVSDENLKLQKEYNPISLLRQIA 125 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYG-------------HIRISDLGLAVKIPEGDL-- 341 G+ LH ++RDLKP+NIL+ I ISD GL K+ G Sbjct: 126 SGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSF 185 Query: 342 ---IRGRVGTVGYMAPEVL---NN----QRYGLSPDYWGLGCLIYEMI-EGQSPFRGRKE 390 + GT G+ APE+L NN +R S D + +GC+ Y ++ +G+ PF + Sbjct: 186 RTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF---GD 242 Query: 391 KVKREE-VDRRVLETEE---VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHP 446 K RE + R + +E ++ EA + ++ D +R A +V RHP Sbjct: 243 KYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKR-----PTAMKVLRHP 297 Query: 447 FF----RNMNF-----KRLEAGMLDPP 464 F + + F RLE DPP Sbjct: 298 LFWPKSKKLEFLLKVSDRLEIENRDPP 324 >5H2U-A nrPDB Length = 267 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 92/208 (44%), Gaps = 8/208 (3%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + F R LG G FGEV + ++ A K + + + ++ M +E Q ++K+ Sbjct: 5 REEFTLCRKLGSGYFGEVFEGLWKDRVQV-AIKVISRDNLLHQQ---MLQSEIQAMKKLR 60 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 + ++ L D + ++ +M G L + + L A ++ G+ L Sbjct: 61 HKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGY--MAPEVLNNQ 360 +N ++RDL NIL+ + ++ D GLA I E D+ + Y APE L+ Sbjct: 121 ESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKE-DVYLSHDHNIPYKWTAPEALSRG 179 Query: 361 RYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 Y D W G L++EM GQ P+ G Sbjct: 180 HYSTKSDVWSFGILLHEMFSRGQVPYPG 207 >4C59-A nrPDB Length = 340 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 74/283 (26%), Positives = 121/283 (42%), Gaps = 46/283 (16%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS-- 243 R RVL +GGF V Q +G+ YA KRL +K + + E ++K++ Sbjct: 29 LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA---IIQEVCFMKKLSGHP 85 Query: 244 ---QFVVNLAYAYETKD---ALCLVLTIMNGGDLKFHIYNMGNPG---FEEERALFYAAE 294 QF + E D A L+LT + G L + M + G + +FY + Sbjct: 86 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFY--Q 143 Query: 295 ILCGLEDLHREN--TVYRDLKPENILLDDYGHIRISDLGLAVKIP--------------- 337 ++ +HR+ ++RDLK EN+LL + G I++ D G A I Sbjct: 144 TCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALV 203 Query: 338 EGDLIRGRVGTVGYMAPEVLN---NQRYGLSPDYWGLGCLIYEMIEGQSPFR-GRKEKVK 393 E ++ R T Y PE+++ N G D W LGC++Y + Q PF G K ++ Sbjct: 204 EEEITRNT--TPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIV 261 Query: 394 REEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + +T+ H S+ + +L + ++RL E Sbjct: 262 NGKYSIPPHDTQYTVFH-------SLIRAMLQVNPEERLSIAE 297 >5HLW-A nrPDB Length = 299 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 95/204 (46%), Gaps = 11/204 (5%) Query: 191 VLGKGGFGEVC-ACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 V+G+G FG V + GK C RI S L E I++ + V++L Sbjct: 27 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 86 Query: 250 -AYAYETKDALCLVLTIMNGGDLKFHIYN-MGNPGFEEERALFYAAEILCGLEDLHRENT 307 ++ + +VL M GDL+ I N NP ++ + + ++ G++ L + Sbjct: 87 LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKD--LIGFGLQVAKGMKYLASKKF 144 Query: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL--IRGRVGT---VGYMAPEVLNNQRY 362 V+RDL N +LD+ ++++D GLA + + + + + G V +MA E L Q++ Sbjct: 145 VHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQKF 204 Query: 363 GLSPDYWGLGCLIYE-MIEGQSPF 385 D W G L++E M G P+ Sbjct: 205 TTKSDVWSFGVLLWELMTRGAPPY 228 >2QKW-B nrPDB Length = 321 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 93/207 (44%), Gaps = 9/207 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 N F ++G G FG+V +R K+ L+++ + +G E + L Sbjct: 39 NNFDHKFLIGHGVFGKVYKGVLRDGAKV----ALKRRTPESSQGIEEFETEIETLSFCRH 94 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP--GFEEERALFYAAEILCGLED 301 +V+L + ++ + L+ M G+LK H+Y P E+ L GL Sbjct: 95 PHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHY 154 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---LIRGRVGTVGYMAPEVLN 358 LH ++RD+K NILLD+ +I+D G++ K E D L GT+GY+ PE Sbjct: 155 LHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFI 214 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPF 385 R D + G +++E++ +S Sbjct: 215 KGRLTEKSDVYSFGVVLFEVLCARSAI 241 >2FO0-A nrPDB Length = 495 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 97/219 (44%), Gaps = 15/219 (6%) Query: 174 KW-LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMAL 232 KW +ER +T LG G +GEV + A K L++ ++ + L Sbjct: 211 KWEMERTDITMK-----HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE----FL 261 Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 E +++++ +V L + ++ M G+L ++ L+ A Sbjct: 262 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 321 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---V 349 +I +E L ++N ++R+L N L+ + ++++D GL+ ++ GD G + Sbjct: 322 TQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLS-RLMTGDTYTAHAGAKFPI 380 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 + APE L ++ + D W G L++E+ G SP+ G Sbjct: 381 KWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 419 >3KRL-A nrPDB Length = 335 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 107/234 (45%), Gaps = 24/234 (10%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK--RKGESMAL-N 233 E+ +N + + LG G FG+V GK A ++ K +K E AL + Sbjct: 39 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS 98 Query: 234 EKQILEKVNS-QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE-------- 284 E +I+ + + +VNL A + ++ GDL + PG E Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHN 158 Query: 285 -EERA-----LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI-RISDLGLAVKIP 337 EE+ L +++++ G+ L +N ++RD+ N+LL + GH+ +I D GLA I Sbjct: 159 PEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDIM 217 Query: 338 EGD--LIRGRVGT-VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 +++G V +MAPE + + Y + D W G L++E+ G +P+ G Sbjct: 218 NDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPG 271 >4E20-A nrPDB Length = 290 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 67/242 (27%), Positives = 111/242 (45%), Gaps = 25/242 (10%) Query: 183 KNTFRQYRVLGKGGFGEV---CACQVR-ATGKMYACKRL-EKKRIKKRKGESMALNEKQI 237 K ++ R LG+G FG+V C TG+M A K L E + R G E +I Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ---REIEI 63 Query: 238 LEKVNSQFVVNLAYAYETK--DALCLVLTIMNGGDLKFHI--YNMGNPGFEEERALFYAA 293 L + + +V E + ++ LV+ + G L+ ++ + +G + L +A Sbjct: 64 LRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLA-----QLLLFAQ 118 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRV---GTV 349 +I G+ LH ++ ++R L N+LLD+ ++I D GLA +PEG + R R V Sbjct: 119 QICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPV 178 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMI----EGQSPFRGRKEKVKREEVDRRVLETE 405 + APE L ++ + D W G +YE++ QSP E + + VL Sbjct: 179 FWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLT 238 Query: 406 EV 407 E+ Sbjct: 239 EL 240 >3GQL-A nrPDB Length = 326 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 28/222 (12%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM------ALNEKQILEKVNS-Q 244 LG+G FG+V + K R+ K +K K ++ ++E ++++ + + Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKP-NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK 94 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE---------EERA-----LF 290 ++NL A L +++ + G+L+ ++ PG E EE+ + Sbjct: 95 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 154 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GRV 346 A ++ G+E L + ++RDL N+L+ + ++I+D GLA I D + GR+ Sbjct: 155 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 214 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 V +MAPE L ++ Y D W G L++E+ G SP+ G Sbjct: 215 -PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 255 >3OZ6-A nrPDB Length = 388 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 105/238 (44%), Gaps = 38/238 (15%) Query: 181 VTKNTFRQYRV---LGKGGFGEVCACQVRATGKMYACKRL-----EKKRIKKRKGESMAL 232 V ++ R+Y + LGKG +G V R TG++ A K++ ++ E M L Sbjct: 3 VDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMIL 62 Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 E E + + ++N+ A +D V + + + H N E + Sbjct: 63 TELSGHENIVN--LLNVLRADNDRD----VYLVFDYMETDLHAVIRANI-LEPVHKQYVV 115 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA--------------VKIPE 338 +++ ++ LH ++RD+KP NILL+ H++++D GL+ + I E Sbjct: 116 YQLIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINE 175 Query: 339 GD--------LIRGRVGTVGYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 ++ V T Y APE+ L + +Y D W LGC++ E++ G+ F G Sbjct: 176 NTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPG 233 >3BEA-A nrPDB Length = 333 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 104/232 (44%), Gaps = 22/232 (9%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK--RKGESMAL-N 233 E+ +N + + LG G FG+V GK A ++ K +K E AL + Sbjct: 39 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS 98 Query: 234 EKQILEKVNS-QFVVNLAYAYETKDALCLVLTIMNGGDLKFHI------------YNMGN 280 E +I+ + + +VNL A + ++ GDL + + + N Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIAN 158 Query: 281 PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI-RISDLGLAVKIPEG 339 L +++++ G+ L +N ++RD+ N+LL + GH+ +I D GLA I Sbjct: 159 STLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDIMND 217 Query: 340 D--LIRGRVGT-VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 +++G V +MAPE + + Y + D W G L++E+ G +P+ G Sbjct: 218 SNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPG 269 >5A46-A nrPDB Length = 386 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 28/222 (12%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM------ALNEKQILEKVNS-Q 244 LG+G FG+V + K R+ K +K K ++ ++E ++++ + + Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKP-NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK 106 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE---------EERA-----LF 290 ++NL A L +++ + G+L+ ++ PG E EE+ + Sbjct: 107 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 166 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GRV 346 A ++ G+E L + ++RDL N+L+ + ++I+D GLA I D + GR+ Sbjct: 167 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 226 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 V +MAPE L ++ Y D W G L++E+ G SP+ G Sbjct: 227 -PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 267 >3ZBF-A nrPDB Length = 322 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 65/226 (28%), Positives = 95/226 (42%), Gaps = 24/226 (10%) Query: 180 PVTKNTFRQYRVLGKGGFGEV---CACQVRATGK---MYACKRLEKKRIKKRKGESMALN 233 P K T R +LG G FGEV A + G A K L+K + K E L Sbjct: 31 PREKLTLR--LLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIE--FLK 86 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDL-----KFHIYNMGNPGFEEERA 288 E ++ K N ++ + ++L +M GGDL K + P Sbjct: 87 EAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDL 146 Query: 289 LFYAAEILCGLEDLHRENTVYRDLKPENILLD--DYGH---IRISDLGLAVKIPEGDLIR 343 + +I G L R + ++RDL N L+ DY ++I D GLA I + D R Sbjct: 147 VDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYR 206 Query: 344 GR---VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPF 385 R + V +MAPE L + + D W G LI+E++ G P+ Sbjct: 207 KRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPY 252 >2PSQ-A nrPDB Length = 370 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 103/223 (46%), Gaps = 30/223 (13%) Query: 192 LGKGGFGEVCACQVRATGK-------MYACKRLEKKRIKKRKGESMALNEKQILEKVNS- 243 LG+G FG+V + K A K L+ +K + ++E ++++ + Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSD--LVSEMEMMKMIGKH 146 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE---------EERALFY--- 291 + ++NL A L +++ + G+L+ ++ PG E EE+ F Sbjct: 147 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 206 Query: 292 --AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GR 345 ++ G+E L + ++RDL N+L+ + ++I+D GLA I D + GR Sbjct: 207 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 266 Query: 346 VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 + V +MAPE L ++ Y D W G L++E+ G SP+ G Sbjct: 267 L-PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 308 >3TT0-A nrPDB Length = 382 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 28/222 (12%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM------ALNEKQILEKVNS-Q 244 LG+G FG+V + K R+ K +K K ++ ++E ++++ + + Sbjct: 77 LGEGAFGQVVLAEAIGLDK-DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK 135 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE---------EERA-----LF 290 ++NL A L +++ + G+L+ ++ PG E EE+ + Sbjct: 136 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVS 195 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GRV 346 A ++ G+E L + ++RDL N+L+ + ++I+D GLA I D + GR+ Sbjct: 196 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 255 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 V +MAPE L ++ Y D W G L++E+ G SP+ G Sbjct: 256 -PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 296 >4PWN-A nrPDB Length = 274 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 93/201 (46%), Gaps = 11/201 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G F V T A L+ +++ K + + E ++L+ + +V Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFK-EEAEMLKGLQHPNIVRFYD 76 Query: 252 AYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN- 306 ++E+ K + LV +M G LK ++ + R+ + +IL GL+ LH Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRS--WCRQILKGLQFLHTRTP 134 Query: 307 -TVYRDLKPENILLDD-YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 ++RDLK +NI + G ++I DLGLA + +GT +MAPE + ++Y Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE-MYEEKYDE 193 Query: 365 SPDYWGLGCLIYEMIEGQSPF 385 S D + G + EM + P+ Sbjct: 194 SVDVYAFGMCMLEMATSEYPY 214 >4OW8-A nrPDB Length = 283 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 90/216 (41%), Gaps = 23/216 (10%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK---------RIKKRKGESMALNEKQ 236 +R R++ GG G+V G+ A K L+ + R + + LN Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 72 Query: 237 ILEKVN---SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 I + SQ AY LV+ ++NG L + G AL Sbjct: 73 IASVHDYGESQMNGEGRTAY-------LVMELVNGEPLNSVLKRTGR--LSLRHALDMLE 123 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRV-GTVGY 351 + L+ H V+RD+KP NIL+ G ++I+D G+A + + + G V GT Y Sbjct: 124 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 183 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 +APE + D + LG + YE + G+ PF G Sbjct: 184 IAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAG 219 >5FM2-A nrPDB Length = 355 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 63/230 (27%), Positives = 101/230 (43%), Gaps = 35/230 (15%) Query: 190 RVLGKGGFGEVCACQV-----RATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + LG+G FG+V RA A K L++ + L+E +L++VN Sbjct: 70 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD--LLSEFNVLKQVNHP 127 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGF--------------EEERA 288 V+ L A L L++ G L+ + PG+ +ERA Sbjct: 128 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 187 Query: 289 LF------YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI 342 L +A +I G++ L V+RDL NIL+ + ++ISD GL+ + E D Sbjct: 188 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 247 Query: 343 ----RGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 +GR+ V +MA E L + Y D W G L++E++ G +P+ G Sbjct: 248 VKRSQGRI-PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 296 >3GC0-A nrPDB Length = 329 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 13/213 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 +R+ LG+G +GEV T + A KR+ + ++ A+ E +L+++ + Sbjct: 36 YRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEH-EEEGVPGTAIREVSLLKELQHRN 94 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++ L L L+ DLK Y NP + +++ G+ H Sbjct: 95 IIELKSVIHHNHRLHLIFEYAEN-DLK--KYMDKNPDVSMRVIKSFLYQLINGVNFCHSR 151 Query: 306 NTVYRDLKPENILL-----DDYGHIRISDLGL--AVKIPEGDLIRGRVGTVGYMAPEVLN 358 ++RDLKP+N+LL + ++I D GL A IP + T+ Y PE+L Sbjct: 152 RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTH-EIITLWYRPPEILL 210 Query: 359 NQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390 R Y S D W + C+ EM+ F G E Sbjct: 211 GSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSE 243 >1JPA-A nrPDB Length = 312 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 100/209 (47%), Gaps = 19/209 (9%) Query: 190 RVLGKGGFGEVCACQVRATGK---MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 +V+G G FGEVC+ ++ GK A K L+ +K++ + L+E I+ + + V Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRD--FLSEASIMGQFDHPNV 96 Query: 247 VNLAYAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++L + ++ M G L F N G F + + I G++ L Sbjct: 97 IHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQ--FTVIQLVGMLRGIAAGMKYLADM 154 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL--------IRGRVGTVGYMAPEVL 357 N V+RDL NIL++ ++SD GL+ + E D + G++ + + APE + Sbjct: 155 NYVHRDLAARNILVNSNLVCKVSDFGLS-RFLEDDTSDPTYTSALGGKI-PIRWTAPEAI 212 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPF 385 +++ + D W G +++E++ G+ P+ Sbjct: 213 QYRKFTSASDVWSYGIVMWEVMSYGERPY 241 >4K33-A nrPDB Length = 325 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 103/221 (46%), Gaps = 26/221 (11%) Query: 192 LGKGGFGEVCACQVRATGKMYACK--RLEKKRIK---KRKGESMALNEKQILEKVNS-QF 245 LG+G FG+V + K A K + K +K K S ++E ++++ + + Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 103 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE---------EERALFY----- 291 ++NL A L +++ G+L+ + PG + EE+ F Sbjct: 104 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSC 163 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GRVG 347 A ++ G+E L + ++RDL N+L+ + ++I+D GLA + D + GR+ Sbjct: 164 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGRL- 222 Query: 348 TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 V +MAPE L ++ Y D W G L++E+ G SP+ G Sbjct: 223 PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPG 263 >1K9A-A nrPDB Length = 450 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 86/198 (43%), Gaps = 11/198 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-NSQFVVN 248 + +GKG FG+V R C IK L E ++ ++ +S V Sbjct: 199 QTIGKGEFGDVMLGDYRGNKVAVKC-------IKNDATAQAFLAEASVMTQLRHSNLVQL 251 Query: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV 308 L E K L +V M G L ++ + G + L ++ ++ +E L N V Sbjct: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 Query: 309 YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDY 368 +RDL N+L+ + ++SD GL K G++ V + APE L +++ D Sbjct: 312 HRDLAARNVLVSEDNVAKVSDFGLT-KEASSTQDTGKL-PVKWTAPEALREKKFSTKSDV 369 Query: 369 WGLGCLIYEMIE-GQSPF 385 W G L++E+ G+ P+ Sbjct: 370 WSFGILLWEIYSFGRVPY 387 >4X3F-A nrPDB Length = 337 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 90/216 (41%), Gaps = 23/216 (10%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK---------RIKKRKGESMALNEKQ 236 +R R++ GG G+V G+ A K L+ + R + + LN Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 73 Query: 237 ILEKVN---SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 I + SQ AY LV+ ++NG L + G AL Sbjct: 74 IASVHDYGESQMNGEGRTAY-------LVMELVNGEPLNSVLKRTGR--LSLRHALDMLE 124 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRV-GTVGY 351 + L+ H V+RD+KP NIL+ G ++I+D G+A + + + G V GT Y Sbjct: 125 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 184 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 +APE + D + LG + YE + G+ PF G Sbjct: 185 IAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAG 220 >4EUT-A nrPDB Length = 396 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 53/228 (23%), Positives = 101/228 (44%), Gaps = 19/228 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 +LG+G V + + TG ++A K I + + + E ++L+K+N + +V L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKL- 72 Query: 251 YAYE---TKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGLEDLHREN 306 +A E T L++ G L + N G E L +++ G+ L Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 307 TVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL----- 357 V+R++KP NI+ D +++D G A ++ + + GT Y+ P++ Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 358 ---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVL 402 + ++YG + D W +G Y G PFR + + +EV +++ Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >2WTK-C nrPDB Length = 305 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 47/168 (27%), Positives = 80/168 (47%), Gaps = 8/168 (4%) Query: 227 GESMALNEKQILEKVNSQFVVNLAYAY--ETKDALCLVLTIMNGGDLKFHIYNMGNPGFE 284 GE+ E Q+L ++ + V+ L E K + +V+ G ++ + ++ F Sbjct: 49 GEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFP 107 Query: 285 EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI---PEGDL 341 +A Y +++ GLE LH + V++D+KP N+LL G ++IS LG+A + D Sbjct: 108 VCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDT 167 Query: 342 IRGRVGTVGYMAPEVLN--NQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 R G+ + PE+ N + G D W G +Y + G PF G Sbjct: 168 CRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG 215 >2OGV-A nrPDB Length = 317 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 104/228 (45%), Gaps = 18/228 (7%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK--RKGESMAL-N 233 E+ +N + + LG G FG+V GK A ++ K +K E AL + Sbjct: 31 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS 90 Query: 234 EKQILEKVNS-QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA---- 288 E +I+ + + +VNL A + ++ GDL + ++E Sbjct: 91 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLE 150 Query: 289 ----LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI-RISDLGLAVKIPEGD--L 341 L +++++ G+ L +N ++RD+ N+LL + GH+ +I D GLA I + Sbjct: 151 LRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDIMNDSNYI 209 Query: 342 IRGRVGT-VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 ++G V +MAPE + + Y + D W G L++E+ G +P+ G Sbjct: 210 VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPG 257 >1BYG-A nrPDB Length = 278 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 92/220 (41%), Gaps = 15/220 (6%) Query: 168 DRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG 227 D F + W + + + +GKG FG+V R C IK Sbjct: 9 DEFYRSGW----ALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-------IKNDAT 57 Query: 228 ESMALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286 L E ++ ++ +S V L E K L +V M G L ++ + G + Sbjct: 58 AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 117 Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV 346 L ++ ++ +E L N V+RDL N+L+ + ++SD GL K G++ Sbjct: 118 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT-KEASSTQDTGKL 176 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPF 385 V + APE L +++ D W G L++E+ G+ P+ Sbjct: 177 -PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPY 215 >6BSD-A nrPDB Length = 876 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 57/224 (25%), Positives = 92/224 (41%), Gaps = 38/224 (16%) Query: 192 LGKGGFGEVCACQV----------------RATGKMYACKRLEKKRIKKRKGESMALNEK 235 LG+G FGEV C+V + + A K L K + + L E Sbjct: 579 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARND--FLKEV 636 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM--------GNPG----- 282 +I+ ++ ++ L D LC++ M GDL + G PG Sbjct: 637 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAA 696 Query: 283 ----FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE 338 L AA+I G+ L N V+RDL N L+ + I+I+D G++ + Sbjct: 697 QGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA 756 Query: 339 GDLIR--GR-VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMI 379 GD R GR V + +MA E + ++ + D W G ++E++ Sbjct: 757 GDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 800 >6NT9-A nrPDB Length = 742 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 53/228 (23%), Positives = 101/228 (44%), Gaps = 19/228 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 +LG+G V + + TG ++A K I + + + E ++L+K+N + +V L Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKL- 70 Query: 251 YAYE---TKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGLEDLHREN 306 +A E T L++ G L + N G E L +++ G+ L Sbjct: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 Query: 307 TVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL----- 357 V+R++KP NI+ D +++D G A ++ + + GT Y+ P++ Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 Query: 358 ---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVL 402 + ++YG + D W +G Y G PFR + + +EV +++ Sbjct: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 >2R2P-A nrPDB Length = 295 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 98/206 (47%), Gaps = 15/206 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKM---YACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 RV+G G FGEVC+ +++ GK A K L+ +K++ + L E I+ + + + Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRD--FLGEASIMGQFDHPNI 85 Query: 247 VNLAYAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++L + +V M G L F N G F + + I G++ L Sbjct: 86 IHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQ--FTVIQLVGMLRGISAGMKYLSDM 143 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-----LIRGRVGTVGYMAPEVLNNQ 360 V+RDL NIL++ ++SD GL+ ++ E D RG + + APE + + Sbjct: 144 GYVHRDLAARNILINSNLVCKVSDFGLS-RVLEDDPEAAYTTRGGKIPIRWTAPEAIAFR 202 Query: 361 RYGLSPDYWGLGCLIYEMIE-GQSPF 385 ++ + D W G +++E++ G+ P+ Sbjct: 203 KFTSASDVWSYGIVMWEVVSYGERPY 228 >3PPZ-A nrPDB Length = 309 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 89/198 (44%), Gaps = 7/198 (3%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G FG V + G A K L ++ + L E I++++ +V Sbjct: 45 IGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEF-LREVAIMKRLRHPNIVLFMG 101 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMG-NPGFEEERALFYAAEILCGLEDLHREN--TV 308 A L +V ++ G L ++ G +E R L A ++ G+ LH N V Sbjct: 102 AVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIV 161 Query: 309 YRDLKPENILLDDYGHIRISDLGLA-VKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD 367 +RDLK N+L+D +++ D GL+ +K + GT +MAPEVL ++ D Sbjct: 162 HRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSD 221 Query: 368 YWGLGCLIYEMIEGQSPF 385 + G +++E+ Q P+ Sbjct: 222 VYSFGVILWELATLQQPW 239 >4EUU-A nrPDB Length = 319 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/240 (22%), Positives = 105/240 (43%), Gaps = 19/240 (7%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 Q + + + +LG+G V + + TG ++A K I + + + E ++L Sbjct: 4 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVL 61 Query: 239 EKVNSQFVVNLAYAYE---TKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAE 294 +K+N + +V L +A E T L++ G L + N G E L + Sbjct: 62 KKLNHKNIVKL-FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 120 Query: 295 ILCGLEDLHRENTVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVG 350 ++ G+ L V+R++KP NI+ D +++D G A ++ + + GT Sbjct: 121 VVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 180 Query: 351 YMAPEVL--------NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVL 402 Y+ P++ + ++YG + D W +G Y G PFR + + +EV +++ Sbjct: 181 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >5U6C-A nrPDB Length = 315 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 101/228 (44%), Gaps = 17/228 (7%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVR---ATGKMYACKRLEKKRIKKRKGESMAL 232 LE + +N ++LG+G FG V ++ T A K ++ +R+ E L Sbjct: 28 LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEF-L 86 Query: 233 NEKQILEKVNSQFVVNLA-----YAYETKDALCLVLTIMNGGDLKFHIY----NMGNPGF 283 +E ++ + V+ L + + ++L M GDL ++ G Sbjct: 87 SEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHI 146 Query: 284 EEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR 343 + L + +I G+E L N ++RDL N +L D + ++D GL+ KI GD R Sbjct: 147 PLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYR 206 Query: 344 -GRVGT--VGYMAPEVLNNQRYGLSPDYWGLGCLIYEM-IEGQSPFRG 387 GR+ V ++A E L ++ Y D W G ++E+ G +P+ G Sbjct: 207 QGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 254 >6HV0-A nrPDB Length = 416 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 60/193 (31%), Positives = 90/193 (46%), Gaps = 32/193 (16%) Query: 298 GLEDLHRENTVYRDLKPENILL---DDYGHIR--ISDLGLAVKIPEG----DLIRGRVGT 348 GL LH N V+RDLKP NIL+ + +G I+ ISD GL K+ G G GT Sbjct: 114 GLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGT 173 Query: 349 VGYMAPEVLN-----NQRYGLSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDRRVL 402 G++APE+L+ N Y + D + GC+ Y +I EG PF ++ + L Sbjct: 174 EGWIAPEMLSEDCKENPTYTV--DIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSL 231 Query: 403 ETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF----RNMNF----- 453 + H+ A+ + + ++ D ++R A V +HPFF + + F Sbjct: 232 DCLHPEKHE-DVIARELIEKMIAMDPQKR-----PSAKHVLKHPFFWSLEKQLQFFQDVS 285 Query: 454 KRLEAGMLDPPFV 466 R+E LD P V Sbjct: 286 DRIEKESLDGPIV 298 >5LPZ-A nrPDB Length = 332 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 93/209 (44%), Gaps = 12/209 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 N F ++G GGFG+V ++ G A K+L +G+ + E + + K+ Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHV---SGQGDREFMAEMETIGKIKH 72 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC--GLED 301 + +V L + D LV M G L+ +++ G + + I GL Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 302 LHRE---NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL---IRGRVGTVGYMAPE 355 LH + ++RD+K N+LLD+ R+SD G+A + D + GT GY+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSP 384 + R D + G ++ E++ G+ P Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >5LPV-A nrPDB Length = 296 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 93/209 (44%), Gaps = 12/209 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 N F ++G GGFG+V ++ G A K+L +G+ + E + + K+ Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHV---SGQGDREFMAEMETIGKIKH 72 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC--GLED 301 + +V L + D LV M G L+ +++ G + + I GL Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 302 LHRE---NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL---IRGRVGTVGYMAPE 355 LH + ++RD+K N+LLD+ R+SD G+A + D + GT GY+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSP 384 + R D + G ++ E++ G+ P Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >4CRL-A nrPDB Length = 406 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 41/117 (35%), Positives = 62/117 (52%), Gaps = 13/117 (11%) Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILL----DDYGHIRISDLGLAVKI-----P 337 ++L Y +IL G+ LH ++RDLKP NIL+ + G ++I+D+G A P Sbjct: 132 KSLLY--QILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKP 189 Query: 338 EGDLIRGRVGTVGYMAPEVLNNQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVK 393 DL V T Y APE+L R Y + D W +GC+ E++ + F R+E +K Sbjct: 190 LADL-DPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIK 245 >3DTC-A nrPDB Length = 271 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 90/208 (43%), Gaps = 16/208 (7%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 ++G GGFG+V R + + E++ E ++ + ++ L Sbjct: 14 IIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVR-QEAKLFAMLKHPNIIALR 72 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV-- 308 + LCLV+ GG L + P + + +A +I G+ LH E V Sbjct: 73 GVCLKEPNLCLVMEFARGGPLNRVLSGKRIP---PDILVNWAVQIARGMNYLHDEAIVPI 129 Query: 309 -YRDLKPENILL------DDYGH--IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 +RDLK NIL+ D + ++I+D GLA + + G +MAPEV+ Sbjct: 130 IHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGAYAWMAPEVIRA 188 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 + D W G L++E++ G+ PFRG Sbjct: 189 SMFSKGSDVWSYGVLLWELLTGEVPFRG 216 >6B2Q-A nrPDB Length = 317 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 90/216 (41%), Gaps = 23/216 (10%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK---------RIKKRKGESMALNEKQ 236 +R R++ GG G+V G+ A K L+ + R + + LN Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 93 Query: 237 ILEKVN---SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 I + SQ AY LV+ ++NG L + G AL Sbjct: 94 IASVHDYGESQMNGEGRTAY-------LVMELVNGEPLNSVLKRTGR--LSLRHALDMLE 144 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRV-GTVGY 351 + L+ H V+RD+KP NIL+ G ++I+D G+A + + + G V GT Y Sbjct: 145 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 204 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 +APE + D + LG + YE + G+ PF G Sbjct: 205 IAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAG 240 >6O8B-A nrPDB Length = 665 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/228 (23%), Positives = 101/228 (44%), Gaps = 19/228 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 +LG+G V + + TG ++A K I + + + E ++L+K+N + +V L Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKL- 78 Query: 251 YAYE---TKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGLEDLHREN 306 +A E T L++ G L + N G E L +++ G+ L Sbjct: 79 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 138 Query: 307 TVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL----- 357 V+R++KP NI+ D +++D G A ++ + + GT Y+ P++ Sbjct: 139 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVL 198 Query: 358 ---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVL 402 + ++YG + D W +G Y G PFR + + +EV +++ Sbjct: 199 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 246 >2W1I-A nrPDB Length = 326 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 12/197 (6%) Query: 192 LGKGGFGEVCACQVRA----TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 LGKG FG V C+ TG++ A K+L+ + + + + L+ N Sbjct: 49 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 108 Query: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENT 307 + Y+ ++ L L++ + G L+ ++ + + L Y ++I G+E L + Sbjct: 109 GVCYSAGRRN-LKLIMEYLPYGSLRDYL-QKHKERIDHIKLLQYTSQICKGMEYLGTKRY 166 Query: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG-----YMAPEVLNNQRY 362 ++RDL NIL+++ ++I D GL +P+ D +V G + APE L ++ Sbjct: 167 IHRDLATRNILVENENRVKIGDFGLTKVLPQ-DKEYYKVKEPGESPIFWYAPESLTESKF 225 Query: 363 GLSPDYWGLGCLIYEMI 379 ++ D W G ++YE+ Sbjct: 226 SVASDVWSFGVVLYELF 242 >5GRN-A nrPDB Length = 356 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 69/289 (23%), Positives = 112/289 (38%), Gaps = 49/289 (16%) Query: 135 QKPCKELFSACAQSV----HEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYR 190 QKP E+ +S+ HEY+ +P DS R ++ R Sbjct: 6 QKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDS-------------RWEFPRDGLVLGR 52 Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIK--KRKGESMAL-NEKQILEKVNSQF-V 246 VLG G FG+V + ++ K +K R E AL +E +I+ + + Sbjct: 53 VLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNI 112 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIY------------------------NMGNPG 282 VNL A + ++ GDL +++ + + G Sbjct: 113 VNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEG 172 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI 342 L + ++ G+E L +N V+RDL N+LL ++I D GLA I Sbjct: 173 LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY 232 Query: 343 RGRVGT---VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 + T V +MAPE + + Y D W G L++E+ G +P+ G Sbjct: 233 VSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPG 281 >5HVK-A nrPDB Length = 315 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 89/204 (43%), Gaps = 19/204 (9%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 VLGKG FG+ R TG++ K L + + + L E +++ + V+ Sbjct: 21 VLGKGCFGQAIKVTHRETGEVMVMKELIRF---DEETQRTFLKEVKVMRCLEHPNVLKFI 77 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 L + + GG L+ I +M + +R F A +I G+ LH N ++R Sbjct: 78 GVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSF-AKDIASGMAYLHSMNIIHR 136 Query: 311 DLKPENILLDDYGHIRISDLGLA---------------VKIPEGDLIRGRVGTVGYMAPE 355 +L N L+ + ++ ++D GLA +K P+ VG +MAPE Sbjct: 137 NLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 196 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMI 379 ++N + Y D + G ++ E+I Sbjct: 197 MINGRSYDEKVDVFSFGIVLCEII 220 >6FYV-A nrPDB Length = 337 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 89/225 (39%), Gaps = 31/225 (13%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ------F 245 LG+G FG+V C M+ ++ K + R+ A +E Q+LE +NS Sbjct: 22 LGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA---ARSEIQVLEHLNSTDPNSVFR 78 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 V + ++ +C+V ++ F N P F+ + A +I + LH Sbjct: 79 CVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLP-FQIDHIRQMAYQICQSINFLHHN 137 Query: 306 NTVYRDLKPENILL--DDY-----------------GHIRISDLGLAVKIPEGDLIRGRV 346 + DLKPENIL DY I++ D G A E V Sbjct: 138 KLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHH--STLV 195 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK 391 T Y APEV+ + D W +GC++ E G + F+ K Sbjct: 196 STRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSK 240 >2I6L-A nrPDB Length = 320 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 87/202 (43%), Gaps = 39/202 (19%) Query: 285 EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI-RISDLGLA-VKIP----E 338 EE A + ++L GL+ +H N ++RDLKP N+ ++ + +I D GLA + P + Sbjct: 119 EEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHK 178 Query: 339 GDLIRGRVGTVGYMAPE-VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE------- 390 G L G V T Y +P +L+ Y + D W GC+ EM+ G++ F G E Sbjct: 179 GHLSEGLV-TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLI 237 Query: 391 ----KVKREEVDRRVLETEEVY-------SHK--------FSEEAKSICKMLLTKDAKQR 431 V EE + +L VY HK S EA + +LT R Sbjct: 238 LESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDR 297 Query: 432 LGCQEEGAAEVKRHPFFRNMNF 453 L A E HP+ +F Sbjct: 298 L-----TAEEALSHPYMSIYSF 314 >2PVN-A nrPDB Length = 352 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 85/203 (41%), Gaps = 36/203 (17%) Query: 260 CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL 319 L+ +N D K +Y P + +Y E+L L+ H + ++RD+KP N+++ Sbjct: 125 SLIFEYVNNTDFKV-LY----PTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMI 179 Query: 320 D-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYE 377 D + +R+ D GLA G RV + + PE+L + Q Y S D W LGC+ Sbjct: 180 DHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAG 239 Query: 378 MIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDA-----KQRL 432 MI + PF Y H ++ I K+L T K R+ Sbjct: 240 MIFRKEPF---------------------FYGHDNHDQLVKIAKVLGTDGLNAYLNKYRI 278 Query: 433 GCQEEGAAEVKRH---PFFRNMN 452 + A V RH P+ + MN Sbjct: 279 ELDPQLEALVGRHSRKPWLKFMN 301 >6DBN-A nrPDB Length = 316 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 101/221 (45%), Gaps = 21/221 (9%) Query: 177 ERQPVT--------KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGE 228 E++P T K ++ R LG+G FG+V C+ G +++ K +K G Sbjct: 20 EKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG-EQVAVKSLKPESGG 78 Query: 229 SMALNEKQILEKVNSQFVVNLAY-----AYETKDALCLVLTIMNGGDLKFHIYNMGNPGF 283 + + K+ +E + + + N+ + + + L++ + G LK ++ N Sbjct: 79 NHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK-I 137 Query: 284 EEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD--- 340 ++ L YA +I G++ L V+RDL N+L++ ++I D GL I E D Sbjct: 138 NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAI-ETDKEY 196 Query: 341 --LIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMI 379 + R V + APE L ++ ++ D W G ++E++ Sbjct: 197 YTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELL 237 >5X02-A nrPDB Length = 347 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 72/291 (24%), Positives = 122/291 (41%), Gaps = 40/291 (13%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGES---MALNEKQILEKVNS-QF 245 +VLG G FG+V K ++ K +K++ S ++E +++ ++ S + Sbjct: 54 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHEN 113 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDL---------KF---HIYNMGNPGFEEER------ 287 +VNL A + L+ GDL KF I EEE Sbjct: 114 IVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLT 173 Query: 288 ---ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD--LI 342 L +A ++ G+E L ++ V+RDL N+L+ ++I D GLA I ++ Sbjct: 174 FEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVV 233 Query: 343 RGRVGT-VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRR 400 RG V +MAPE L Y + D W G L++E+ G +P+ G ++ + Sbjct: 234 RGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQN 293 Query: 401 VLETEEVYSHKFSEEAKSICKMLLTKDAKQR---------LGCQEEGAAEV 442 + ++ + +EE I + D+++R LGCQ A E Sbjct: 294 GFKMDQPFYA--TEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEA 342 >1LUF-A nrPDB Length = 343 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 92/238 (38%), Gaps = 37/238 (15%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATG-------KMYACKRLEKKRIKKRKGESMALNEK 235 +N R +G+G FG V Q RA G M A K L+++ + + E Sbjct: 46 RNNIEYVRDIGEGAFGRVF--QARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ--REA 101 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM----------------- 278 ++ + ++ +V L +CL+ M GDL + +M Sbjct: 102 ALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRA 161 Query: 279 -----GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA 333 G P L A ++ G+ L V+RDL N L+ + ++I+D GL+ Sbjct: 162 RVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLS 221 Query: 334 VKIPEGDLIRG---RVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 I D + + +M PE + RY D W G +++E+ G P+ G Sbjct: 222 RNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 279 >4XUF-A nrPDB Length = 297 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 99/227 (43%), Gaps = 29/227 (12%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGES---MALNEKQILEKVNS-QF 245 +VLG G FG+V K ++ K +K++ S ++E +++ ++ S + Sbjct: 15 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHEN 74 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDL---------KF---HIYNMGNPGFEEER------ 287 +VNL A + L+ GDL KF I EEE Sbjct: 75 IVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLT 134 Query: 288 ---ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD--LI 342 L +A ++ G+E L ++ V+RDL N+L+ ++I D GLA I ++ Sbjct: 135 FEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVV 194 Query: 343 RGRVGT-VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 RG V +MAPE L Y + D W G L++E+ G +P+ G Sbjct: 195 RGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPG 241 >3IO7-A nrPDB Length = 313 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 49/196 (25%), Positives = 93/196 (47%), Gaps = 12/196 (6%) Query: 192 LGKGGFGEVCACQVRA----TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 LGKG FG V C+ TG++ A K+L+ + + + + L+ N Sbjct: 36 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 95 Query: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENT 307 + Y+ ++ L L++ + G L+ ++ + + L Y ++I G+E L + Sbjct: 96 GVCYSAGRRN-LKLIMEYLPYGSLRDYL-QKHKERIDHIKLLQYTSQICKGMEYLGTKRY 153 Query: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG-----YMAPEVLNNQRY 362 ++RDL NIL+++ ++I D GL +P+ D +V G + APE L ++ Sbjct: 154 IHRDLATRNILVENENRVKIGDFGLTKVLPQ-DKEYYKVKEPGESPIFWYAPESLTESKF 212 Query: 363 GLSPDYWGLGCLIYEM 378 ++ D W G ++YE+ Sbjct: 213 SVASDVWSFGVVLYEL 228 >3M42-A nrPDB Length = 299 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 70/277 (25%), Positives = 114/277 (41%), Gaps = 58/277 (20%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ--FVV 247 +VLG G G+V + T + +A K L+ +R+ E L SQ +V Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---------LHWRASQCPHIV 74 Query: 248 NLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + YE + L +V+ ++GG+L I + G+ F E A I ++ LH Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 304 RENTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 N +RD+KPEN+L ++++D G A + T G + Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE------------TTG---------E 173 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFR---------GRKEKVKREEVDRRVLETEEVYSHK 411 +Y S D W LG ++Y ++ G PF G K +++ + + E EV Sbjct: 174 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV---- 229 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 SEE K + + LL + QR+ E HP+ Sbjct: 230 -SEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI 260 >5X5O-A nrPDB Length = 310 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 90/198 (45%), Gaps = 15/198 (7%) Query: 193 GKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYA 252 G G FG V + + K A K+L K I+K E +IL ++ + ++ Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLK--IEK---------EAEILSVLSHRNIIQFYGV 72 Query: 253 YETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE---NTVY 309 +V + G L +I + + + + + +A ++ G+ LH E ++ Sbjct: 73 ILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIH 132 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYW 369 RDLK N+++ G ++I D G A + VGT +MAPEV+ + + D + Sbjct: 133 RDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTY 191 Query: 370 GLGCLIYEMIEGQSPFRG 387 G +++EM+ + PF+G Sbjct: 192 SYGVVLWEMLTREVPFKG 209 >3QGY-A nrPDB Length = 286 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 49/188 (26%), Positives = 83/188 (44%), Gaps = 10/188 (5%) Query: 218 EKKRIKKRKGESMA----LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKF 273 +K IK K SM+ + E +++ K++ +V L + +CLV M G L Sbjct: 52 DKVAIKTIKEGSMSEDDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSD 111 Query: 274 HIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA 333 ++ F E L ++ G+ L ++RDL N L+ + I++SD G+ Sbjct: 112 YLRTQRGL-FAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMT 170 Query: 334 VKIPEGDLIRGRVGT---VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMI-EGQSPFRGRK 389 + D GT V + +PEV + RY D W G L++E+ EG+ P+ R Sbjct: 171 -RFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRS 229 Query: 390 EKVKREEV 397 E++ Sbjct: 230 NSEVVEDI 237 >4FL3-A nrPDB Length = 635 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 95/209 (45%), Gaps = 19/209 (9%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN-----EKQILEKVNSQFV 246 LG G FG V + +M + +I K + AL E +++++++ ++ Sbjct: 377 LGSGNFGTV----KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 V + E ++ LV+ + G L + Y N +++ + ++ G++ L N Sbjct: 433 VRMIGICEA-ESWMLVMEMAELGPL--NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG-----YMAPEVLNNQR 361 V+RDL N+LL + +ISD GL+ K D + T G + APE +N + Sbjct: 490 FVHRDLAARNVLLVTQHYAKISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECINYYK 548 Query: 362 YGLSPDYWGLGCLIYEMIE-GQSPFRGRK 389 + D W G L++E GQ P+RG K Sbjct: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMK 577 >3VHK-A nrPDB Length = 368 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 41/123 (33%), Positives = 65/123 (52%), Gaps = 9/123 (7%) Query: 286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIR- 343 E + Y+ ++ G+E L ++RDL NILL + ++I D GLA I + D +R Sbjct: 200 EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRK 259 Query: 344 --GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRR 400 R+ + +MAPE + ++ Y + D W G L++E+ G SP+ G K EE RR Sbjct: 260 GDARL-PLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKID---EEFCRR 315 Query: 401 VLE 403 + E Sbjct: 316 LKE 318 >2VWV-A nrPDB Length = 302 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 94/205 (45%), Gaps = 13/205 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYAC---KRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 V+G G FGEVC +++A GK +C K L+ ++++ E L+E I+ + ++ Sbjct: 23 VIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRRE--FLSEASIMGQFEHPNII 80 Query: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENT 307 L + ++ M G L + + F + + I G+ L + Sbjct: 81 RLEGVVTNSMPVMILTEFMENGALD-SFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSY 139 Query: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG------YMAPEVLNNQR 361 V+RDL NIL++ ++SD GL+ + E ++G + APE + ++ Sbjct: 140 VHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAFRK 199 Query: 362 YGLSPDYWGLGCLIYEMIE-GQSPF 385 + + D W G +++E++ G+ P+ Sbjct: 200 FTSASDAWSYGIVMWEVMSFGERPY 224 >3DKO-A nrPDB Length = 318 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 97/205 (47%), Gaps = 13/205 (6%) Query: 190 RVLGKGGFGEVCACQVRATGK---MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 RV+G G FGEVC+ +++ GK A K L+ +K++ + L E I+ + + V Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDF--LCEASIMGQFDHPNV 106 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 V+L + +V+ M G L + + F + + I G+ L Sbjct: 107 VHLEGVVTRGKPVMIVIEFMENGALDAFLRKH-DGQFTVIQLVGMLRGIAAGMRYLADMG 165 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKI---PEG--DLIRGRVGTVGYMAPEVLNNQR 361 V+RDL NIL++ ++SD GL+ I PE G++ V + APE + ++ Sbjct: 166 YVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKI-PVRWTAPEAIQYRK 224 Query: 362 YGLSPDYWGLGCLIYEMIE-GQSPF 385 + + D W G +++E++ G+ P+ Sbjct: 225 FTSASDVWSYGIVMWEVMSYGERPY 249 >4R7H-A nrPDB Length = 343 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 105/241 (43%), Gaps = 31/241 (12%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK--RKGESMAL-N 233 E+ +N + + LG G FG+V GK A ++ K +K E AL + Sbjct: 43 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMS 102 Query: 234 EKQILEKVNS-QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--------NPG-- 282 E +I+ + + +VNL A + ++ GDL + +PG Sbjct: 103 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQD 162 Query: 283 -----------FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHI-RISDL 330 E L +++++ G+ L +N ++RD+ N+LL + GH+ +I D Sbjct: 163 PEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGDF 221 Query: 331 GLAVKIPEGD--LIRGRVGT-VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFR 386 GLA I +++G V +MAPE + + Y + D W G L++E+ G +P+ Sbjct: 222 GLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYP 281 Query: 387 G 387 G Sbjct: 282 G 282 >2GCD-A nrPDB Length = 309 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 83/203 (40%), Gaps = 8/203 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F R +G G FG V + ++ A K++ + + + E + L+K+ Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 + Y + LV+ G + + +E L GL LH Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGS--ASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH 134 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV---LNNQRY 362 N ++RD+K NILL + G +++ D G A + + VGT +MAPEV ++ +Y Sbjct: 135 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN---SFVGTPYWMAPEVILAMDEGQY 191 Query: 363 GLSPDYWGLGCLIYEMIEGQSPF 385 D W LG E+ E + P Sbjct: 192 DGKVDVWSLGITCIELAERKPPL 214 >6GQK-A nrPDB Length = 328 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 92/220 (41%), Gaps = 22/220 (10%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGES---MALNEKQILEKV-NSQF 245 + LG G FG+V + K A + K +K + ++E ++L + N + Sbjct: 47 KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHEN 106 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDL---------KFHIYNMGNPGFEE-----ERALFY 291 +VNL A ++ GDL +F Y + + E L + Sbjct: 107 IVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSF 166 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA--VKIPEGDLIRGRVGT- 348 + ++ G+ L +N ++RDL NILL +I D GLA +K + +G Sbjct: 167 SYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNARLP 226 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 V +MAPE + N Y D W G ++E+ G SP+ G Sbjct: 227 VKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPG 266 >5C26-A nrPDB Length = 299 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 95/209 (45%), Gaps = 19/209 (9%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN-----EKQILEKVNSQFV 246 LG G FG V + +M + +I K + AL E +++++++ ++ Sbjct: 35 LGSGNFGTV----KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 90 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 V + E ++ LV+ + G L + Y N +++ + ++ G++ L N Sbjct: 91 VRMIGICEA-ESWMLVMEMAELGPL--NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 147 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG-----YMAPEVLNNQR 361 V+RDL N+LL + +ISD GL+ K D + T G + APE +N + Sbjct: 148 FVHRDLAARNVLLVTQHYAKISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECINYYK 206 Query: 362 YGLSPDYWGLGCLIYEMIE-GQSPFRGRK 389 + D W G L++E GQ P+RG K Sbjct: 207 FSSKSDVWSFGVLMWEAFSYGQKPYRGMK 235 >1U5R-A nrPDB Length = 348 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 83/204 (40%), Gaps = 10/204 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F R +G G FG V + ++ A K++ + + + E + L+K+ Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 + Y + LV+ G + + +E L GL LH Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGS--ASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH 173 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLA-VKIPEGDLIRGRVGTVGYMAPEV---LNNQR 361 N ++RD+K NILL + G +++ D G A + P VGT +MAPEV ++ + Sbjct: 174 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSF----VGTPYWMAPEVILAMDEGQ 229 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPF 385 Y D W LG E+ E + P Sbjct: 230 YDGKVDVWSLGITCIELAERKPPL 253 >3RAW-A nrPDB Length = 381 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 59/240 (24%), Positives = 94/240 (39%), Gaps = 33/240 (13%) Query: 175 WL-ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN 233 WL ER + N LG+G FG+V C A GK ++ + K R+ + +N Sbjct: 48 WLQERYEIVGN-------LGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEIN 100 Query: 234 E-KQILEK--VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF 290 K+I EK N V ++ + +C+ ++ +F N P + Sbjct: 101 VLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQP-YPLPHVRH 159 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDY-------------------GHIRISDLG 331 A ++ L LH + DLKPENIL + IR++D G Sbjct: 160 MAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFG 219 Query: 332 LAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK 391 A E V T Y PEV+ + D W +GC+++E G + F+ + + Sbjct: 220 SATFDHEHHTTI--VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENR 277 >4TPT-A nrPDB Length = 303 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 94/210 (44%), Gaps = 26/210 (12%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 VLGKG FG+ +ATGK+ K L + + +K L E +++ ++ V+ Sbjct: 7 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQK---TFLTEVKVMRSLDHPNVLKFI 63 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 L L+ + GG LK + +M +P F ++ + +A I G+ LH ++R Sbjct: 64 GVLYKDKKLNLLTEYIEGGTLKDFLRSM-DP-FPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 311 DLKPENILLDDYGHIRISDLGLAVKIPE------------------GDLIRGRVGTVG-- 350 DL N L+ + ++D GL+ I E + + R VG Sbjct: 122 DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNP 181 Query: 351 -YMAPEVLNNQRYGLSPDYWGLGCLIYEMI 379 +MAPE+LN + Y + D + G ++ E+I Sbjct: 182 YWMAPEMLNGKSYDETVDIFSFGIVLCEII 211 >3SOC-A nrPDB Length = 322 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 39/100 (39%), Positives = 56/100 (56%), Gaps = 8/100 (8%) Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL---IR 343 R L Y E + GL+D H+ +RD+K +N+LL + I+D GLA+K G Sbjct: 132 RGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTH 191 Query: 344 GRVGTVGYMAPEVL----NNQRYG-LSPDYWGLGCLIYEM 378 G+VGT YMAPEVL N QR L D + +G +++E+ Sbjct: 192 GQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 231 >3PP0-A nrPDB Length = 338 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 94/211 (44%), Gaps = 14/211 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEKV 241 R+ +VLG G FG V G+ A K L + K E L+E ++ V Sbjct: 19 LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKE--ILDEAYVMAGV 76 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY-NMGNPGFEEERALFYAAEILCGLE 300 S +V L T + LV +M G L H+ N G G ++ L + +I G+ Sbjct: 77 GSPYVSRLLGICLTS-TVQLVTQLMPYGCLLDHVRENRGRLGSQD--LLNWCMQIAKGMS 133 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLA--VKIPEGDL-IRGRVGTVGYMAPEVL 357 L V+RDL N+L+ H++I+D GLA + I E + G + +MA E + Sbjct: 134 YLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESI 193 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 +R+ D W G ++E++ G P+ G Sbjct: 194 LRRRFTHQSDVWSYGVTVWELMTFGAKPYDG 224 >2Y6O-A nrPDB Length = 291 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 50/206 (24%), Positives = 99/206 (48%), Gaps = 15/206 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYAC---KRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 +V+G G FGEVC+ +++ GK C K L+ K++ + L+E I+ + + + Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRD--FLSEASIMGQFDHPNI 77 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG-FEEERALFYAAEILCGLEDLHRE 305 ++L + ++ M G L + N G F + + I G++ L Sbjct: 78 IHLEGVVTKCKPVMIITEYMENGSLDAFLRK--NDGRFTVIQLVGMLRGIGSGMKYLSDM 135 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-----LIRGRVGTVGYMAPEVLNNQ 360 + V+RDL NIL++ ++SD G++ ++ E D RG + + APE + + Sbjct: 136 SYVHRDLAARNILVNSNLVCKVSDFGMS-RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYR 194 Query: 361 RYGLSPDYWGLGCLIYEMIE-GQSPF 385 ++ + D W G +++E++ G+ P+ Sbjct: 195 KFTSASDVWSYGIVMWEVMSYGERPY 220 >3ZZW-A nrPDB Length = 289 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 34/116 (29%), Positives = 63/116 (54%), Gaps = 5/116 (4%) Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---LIRGRVGT 348 A+I G+E L + V++DL N+L+ D +++ISDLGL ++ D L+ + Sbjct: 134 VAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLP 193 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEV-DRRVL 402 + +MAPE + ++ + D W G +++E+ G P+ G + E + +R+VL Sbjct: 194 IRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVL 249 >3PLS-A nrPDB Length = 298 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 90/206 (43%), Gaps = 11/206 (5%) Query: 190 RVLGKGGFGEVCACQ-VRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVN 248 RV+GKG FG V + + C RI + + L E ++ +N V+ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 249 LAYAYETKDALCLVLT--IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 L + L VL + +G L+F NP ++ + + ++ G+E L + Sbjct: 87 LIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKD--LISFGLQVARGMEYLAEQK 144 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI-----RGRVGTVGYMAPEVLNNQR 361 V+RDL N +LD+ ++++D GLA I + + R V + A E L R Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 362 YGLSPDYWGLGCLIYEMI-EGQSPFR 386 + D W G L++E++ G P+R Sbjct: 205 FTTKSDVWSFGVLLWELLTRGAPPYR 230 >3RP9-A nrPDB Length = 458 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 96/234 (41%), Gaps = 60/234 (25%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEK--------KRIKKRKGESMALNEKQILEKVN 242 ++G G +G VC + ++ A K++ + KRI L E IL ++N Sbjct: 60 LIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRI---------LREIAILNRLN 110 Query: 243 SQFVVNLAYAYETKDA-----LCLVLTIMNGGDLKFHIYNMGNPGFEEE---RALFYAAE 294 VV + KD L +VL I + K P + E + L Y Sbjct: 111 HDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKL----FRTPVYLTELHIKTLLY--N 164 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA--VKIPEG------------D 340 +L G++ +H ++RDLKP N L++ +++ D GLA V PE D Sbjct: 165 LLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDD 224 Query: 341 L--------------IRGRVGTVGYMAPE-VLNNQRYGLSPDYWGLGCLIYEMI 379 + + G V T Y APE +L + Y + D W +GC+ E++ Sbjct: 225 MNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 >3PG1-A nrPDB Length = 362 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 1/99 (1%) Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTV 349 ++ IL GL LH V+RDL P NILL D I I D LA + V Sbjct: 138 YFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHR 197 Query: 350 GYMAPE-VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 Y APE V+ + + D W GC++ EM ++ FRG Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRG 236 >4AT3-A nrPDB Length = 299 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/227 (24%), Positives = 97/227 (42%), Gaps = 23/227 (10%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQV-----RATGKMYACKRLEKKRIKKRKGESMALN 233 Q + ++ R LG+G FG+V + + A K L+ RK Sbjct: 8 QHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFH---R 64 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDL-KFH--------IYNMGNPGFE 284 E ++L + + +V D L +V M GDL KF + GNP E Sbjct: 65 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE 124 Query: 285 --EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI 342 + + L A +I G+ L ++ V+RDL N L+ + ++I D G++ + D Sbjct: 125 LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYY 184 Query: 343 RGRVGT---VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPF 385 R T + +M PE + +++ D W LG +++E+ G+ P+ Sbjct: 185 RVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPW 231 >5X8I-B nrPDB Length = 346 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 87/220 (39%), Gaps = 31/220 (14%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN-----SQF 245 LG+G FG+V C G + ++ K R E+ A +E Q+LE +N S F Sbjct: 20 TLGEGAFGKVVECIDHKAGGRHVAVKIVKN--VDRYCEA-ARSEIQVLEHLNTTDPNSTF 76 Query: 246 -VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 V + +E +C+V ++ F I G F + A +I + LH Sbjct: 77 RCVQMLEWFEHHGHICIVFELLGLSTYDF-IKENGFLPFRLDHIRKMAYQICKSVNFLHS 135 Query: 305 ENTVYRDLKPENILL--DDYGH-----------------IRISDLGLAVKIPEGDLIRGR 345 + DLKPENIL DY I++ D G A E Sbjct: 136 NKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHH--STL 193 Query: 346 VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 V T Y APEV+ + D W +GC++ E G + F Sbjct: 194 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVF 233 >5TE0-A nrPDB Length = 347 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 63/231 (27%), Positives = 101/231 (43%), Gaps = 30/231 (12%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRL-----EKKRIKKRKGESM 230 + RQ VT + VL +GGF V + + G A KR+ ++ KR+ + M Sbjct: 16 IGRQQVTVD-----EVLAEGGFAIVFLVRT-SNGMKCALKRMFVNNEHDLQVCKREIQIM 69 Query: 231 --ALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA 288 K I+ ++S +N + + + L L + GG + + GF E Sbjct: 70 RDLSGHKNIVGYIDSS--INNVSSGDVWEVLIL-MDFCRGGQVVNLMNQRLQTGFTENEV 126 Query: 289 LFYAAEILCGLEDLHRENT--VYRDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIR 343 L + + LH+ T ++RDLK ENILL D GH + D G A + P+ + + Sbjct: 127 LQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVN 186 Query: 344 G------RVGTVGYMAPEVLN---NQRYGLSPDYWGLGCLIYEMIEGQSPF 385 + T+ Y APE++N + D W LGCL+Y++ PF Sbjct: 187 AVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF 237 >4EBW-A nrPDB Length = 304 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 46/221 (20%), Positives = 99/221 (44%), Gaps = 20/221 (9%) Query: 190 RVLGKGGFGEVCACQVRA------TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 R +G+G FG+V + + CK ++++ L E + + + Sbjct: 44 RCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREK-----FLQEALTMRQFDH 98 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L T++ + +++ + G+L+ + + + + YA ++ L L Sbjct: 99 PHIVKLI-GVITENPVWIIMELCTLGELRSFL-QVRKYSLDLASLILYAYQLSTALAYLE 156 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT--VGYMAPEVLNNQR 361 + V+RD+ N+L+ +++ D GL+ + + + G + +MAPE +N +R Sbjct: 157 SKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRR 216 Query: 362 YGLSPDYWGLGCLIYE-MIEGQSPFRGRKEKVKREEVDRRV 401 + + D W G ++E ++ G PF+G VK +V R+ Sbjct: 217 FTSASDVWMFGVCMWEILMHGVKPFQG----VKNNDVIGRI 253 >3QD2-B nrPDB Length = 332 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 39/143 (27%), Positives = 67/143 (46%), Gaps = 17/143 (11%) Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-------------PEGD 340 +I +E LH + ++RDLKP NI +++ D GL + P Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 231 Query: 341 LIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400 G+VGT YM+PE ++ Y D + LG +++E++ F + E+V R D R Sbjct: 232 THTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYS---FSTQMERV-RIITDVR 287 Query: 401 VLETEEVYSHKFSEEAKSICKML 423 L+ +++ K+ +E + ML Sbjct: 288 NLKFPLLFTQKYPQEHMMVQDML 310 >2J0K-A nrPDB Length = 656 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 43/209 (20%), Positives = 94/209 (44%), Gaps = 16/209 (7%) Query: 190 RVLGKGGFGEVCACQVRA------TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 R +G+G FG+V + + CK ++++ L E + + + Sbjct: 396 RCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREK-----FLQEALTMRQFDH 450 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L T++ + +++ + G+L+ + + + + YA ++ L L Sbjct: 451 PHIVKLI-GVITENPVWIIMELCTLGELRSFL-QVRKFSLDLASLILYAYQLSTALAYLE 508 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT--VGYMAPEVLNNQR 361 + V+RD+ N+L+ +++ D GL+ + + + G + +MAPE +N +R Sbjct: 509 SKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRR 568 Query: 362 YGLSPDYWGLGCLIYE-MIEGQSPFRGRK 389 + + D W G ++E ++ G PF+G K Sbjct: 569 FTSASDVWMFGVCMWEILMHGVKPFQGVK 597 >3AOX-A nrPDB Length = 344 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 89/226 (39%), Gaps = 15/226 (6%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN---EKQI 237 V + R LG G FGEV QV + ++ K + + E L+ E I Sbjct: 44 VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALI 103 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLK-FHIYNMGNPGFEEERALF----YA 292 + K N Q +V ++L +M GGDLK F P A+ A Sbjct: 104 ISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVA 163 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRIS---DLGLAVKIPEGDLIRG---RV 346 +I CG + L + ++RD+ N LL G R++ D G+A I R + Sbjct: 164 RDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAM 223 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEK 391 V +M PE + D W G L++E+ G P+ + + Sbjct: 224 LPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ 269 >6BFN-A nrPDB Length = 342 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 57/236 (24%), Positives = 95/236 (40%), Gaps = 18/236 (7%) Query: 173 WKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRL-EKKRIKKRKGESMA 231 W E T N F + +G+GGFG V +R T +YA KRL E ++ + Sbjct: 12 WPLCEISRGTHN-FSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSF 68 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDL--KFHIYNMGNPGFEEERAL 289 L E + L + +V+ A CLV + G L + H P + L Sbjct: 69 LTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL 128 Query: 290 FYAAEILCGLEDLHREN--TVYRDLKPENILLDDYGHIRISDLGLAV------KIPEGDL 341 ++ LH+++ ++ D+K N+LLD+ ++ D GLA P Sbjct: 129 DILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSS 188 Query: 342 IRGRV----GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVK 393 + R GT+ Y+ E + R + D + G ++ E + GQ + + K Sbjct: 189 MVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTK 244 >4M66-A nrPDB Length = 325 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 100/234 (42%), Gaps = 22/234 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V++ ++ +GKGGFG V R A K + K+I + L + +L Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLL 76 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF--YAAEILCG 298 + +L + + + AL V M G L + P L E++ G Sbjct: 77 LG--VTEDLQWDFVSGQAL--VTRFMENGSLA----GLLQPEAPRPWPLLCRLLQEVVLG 128 Query: 299 LEDLHREN--TVYRDLKPENILLDDYGHIRISDLGLAV-------KIPEGDLIRGRVGTV 349 + LH + ++RDLKP NILLD H +++D GL+ G R GT+ Sbjct: 129 MCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTL 188 Query: 350 GYMAPEVL--NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEV-DRR 400 Y+ PE+L N + + D + G L++ ++ G+ K + RE V DR+ Sbjct: 189 AYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQ 242 >4Y93-A nrPDB Length = 446 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 57/233 (24%), Positives = 103/233 (44%), Gaps = 19/233 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKK-RKGESMALNEKQILEKVNSQFVVNLA 250 LG G FG V GK + K IK+ E + E +++ ++ + +V L Sbjct: 196 LGTGQFG------VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQL- 248 Query: 251 YAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 Y TK ++T M G L ++ M + F+ ++ L ++ +E L + ++ Sbjct: 249 YGVCTKQRPIFIITEYMANGCLLNYLREMRH-RFQTQQLLEMCKDVCEAMEYLESKQFLH 307 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR--GRVGTVGYMAPEVLNNQRYGLSPD 367 RDL N L++D G +++SD G+ + + + G V + +PEVL ++ D Sbjct: 308 RDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSD 367 Query: 368 YWGLGCLIYEMIE-GQSPFRGRKEKVKREEVD------RRVLETEEVYSHKFS 413 W G L++E+ G+ P+ E + R L +E VY+ +S Sbjct: 368 IWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYS 420 >4Y83-A nrPDB Length = 332 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 87/206 (42%), Gaps = 17/206 (8%) Query: 189 YRVLG-----KGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 YR +G +G FG+V Q T K ACK + + K E A Sbjct: 73 YRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQAC--------FRH 124 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + + L A + + L + GG + + + G E ++ +L GL+ LH Sbjct: 125 ENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGP--MREFEIIWVTKHVLKGLDFLH 182 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI-RGRVGTVGYMAPEVLNNQRY 362 + ++ D+KP NI+ + + D GL+V++ E + GT YM+PEV+ + + Sbjct: 183 SKKVIHHDIKPSNIVFMSTKAVLV-DFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGH 241 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGR 388 D + LG + M G P+ R Sbjct: 242 STKADIYSLGATLIHMQTGTPPWVKR 267 >4XCU-A nrPDB Length = 300 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 96/214 (44%), Gaps = 21/214 (9%) Query: 192 LGKGGFGEVCACQVRAT-------GKMYACKRLEKKRIKKRKGESMALNEKQILEKVN-S 243 LG+G FG+V + A K L+ K + ++E ++++ + Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD--LVSEMEVMKLIGRH 82 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF-----YAAEILCG 298 + ++NL + L +++ G+L+ + PG E F A ++ G Sbjct: 83 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARG 142 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GRVGTVGYMAP 354 ++ L ++RDL N+L+ + ++I+D GLA + D + GR+ V +MAP Sbjct: 143 MQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRL-PVKWMAP 201 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 E L ++ Y D W G L++E+ G SP+ G Sbjct: 202 EALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 235 >4H1J-A nrPDB Length = 293 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 94/202 (46%), Gaps = 10/202 (4%) Query: 190 RVLGKGGFGEV---CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 R+LG+G FGEV + A K +K K + M+ E I++ ++ + Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMS--EAVIMKNLDHPHI 87 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 V L E ++ +++ + G+L ++ N + + Y+ +I + L N Sbjct: 88 VKLIGIIE-EEPTWIIMELYPYGELGHYLERNKN-SLKVLTLVLYSLQICKAMAYLESIN 145 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG--TVGYMAPEVLNNQRYGL 364 V+RD+ NIL+ +++ D GL+ I + D + V + +M+PE +N +R+ Sbjct: 146 CVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTT 205 Query: 365 SPDYWGLGCLIYEMIE-GQSPF 385 + D W ++E++ G+ PF Sbjct: 206 ASDVWMFAVCMWEILSFGKQPF 227 >6E4F-A nrPDB Length = 290 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 111/247 (44%), Gaps = 20/247 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKK-RKGESMALNEKQILEKVNSQFVVNLA 250 LG G FG V GK + K IK+ E + E +++ ++ + +V L Sbjct: 39 LGTGQFG------VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQL- 91 Query: 251 YAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 Y TK ++T M G L ++ M + F+ ++ L ++ +E L + ++ Sbjct: 92 YGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLESKQFLH 150 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGYMAPEVLNNQRYGLSP 366 RDL N L++D G +++SD GL+ + + D VG+ V + PEVL ++ Sbjct: 151 RDLAARNCLVNDQGVVKVSDFGLSRYVLD-DEYTSSVGSKFPVRWSPPEVLMYSKFSSKS 209 Query: 367 DYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYS-HKFSEEAKSICKMLL 424 D W G L++E+ G+ P+ E+ E + + +Y H SE+ +I Sbjct: 210 DIWAFGVLMWEIYSLGKMPY----ERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCW 265 Query: 425 TKDAKQR 431 + A +R Sbjct: 266 HEKADER 272 >2JD5-A nrPDB Length = 373 Score = 55.5 bits (132), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 34/101 (33%), Positives = 53/101 (52%), Gaps = 9/101 (8%) Query: 292 AAEILCGLEDLHRE-NTVYRDLKPENILLD------DYGHIRISDLGLAVKIPEGDLIRG 344 + ++L GL+ +HR ++ D+KPEN+L++ + I+I+DLG A E Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEH--YTN 194 Query: 345 RVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 + T Y +PEVL +G D W CLI+E+I G F Sbjct: 195 SIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLF 235 >3BBT-B nrPDB Length = 328 Score = 55.5 bits (132), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 96/215 (44%), Gaps = 22/215 (10%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ +VLG G FG V G+ A K L + K E M +E I+ + Sbjct: 17 LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFM--DEALIMASM 74 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY----NMGNPGFEEERALFYAAEILC 297 + +V L + LV +M G L +++ N+G+ + L + +I Sbjct: 75 DHPHLVRL-LGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGS-----QLLLNWCVQIAK 128 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL----IRGRVGTVGYMA 353 G+ L V+RDL N+L+ H++I+D GLA ++ EGD G + +MA Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLA-RLLEGDEKEYNADGGKMPIKWMA 187 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 E ++ +++ D W G I+E++ G P+ G Sbjct: 188 LECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDG 222 >4RT7-A nrPDB Length = 415 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 50/168 (29%), Positives = 75/168 (44%), Gaps = 11/168 (6%) Query: 286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD--LIR 343 E L +A ++ G+E L ++ V+RDL N+L+ ++I D GLA I ++R Sbjct: 243 EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR 302 Query: 344 GRVGT-VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG-------RKEKVKR 394 G V +MAPE L Y + D W G L++E+ G +P+ G K Sbjct: 303 GNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNG 362 Query: 395 EEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEV 442 ++D+ TEE+Y S A K + LGCQ A E Sbjct: 363 FKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEA 410 >4P5Q-A nrPDB Length = 361 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 48/205 (23%), Positives = 95/205 (46%), Gaps = 13/205 (6%) Query: 190 RVLGKGGFGEVCACQVRATGK---MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 +V+G G FGEVC+ +++ K A K L+ +K++ + L E I+ + + + Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRD--FLGEASIMGQFDHPNI 96 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 + L + +V M G L + + F + + I G++ L Sbjct: 97 IRLEGVVTKSKPVMIVTEYMENGSLDSFLRKH-DAQFTVIQLVGMLRGIASGMKYLSDMG 155 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-----LIRGRVGTVGYMAPEVLNNQR 361 V+RDL NIL++ ++SD GL+ ++ E D RG + + +PE + ++ Sbjct: 156 YVHRDLAARNILINSNLVCKVSDFGLS-RVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK 214 Query: 362 YGLSPDYWGLGCLIYEMIE-GQSPF 385 + + D W G +++E++ G+ P+ Sbjct: 215 FTSASDVWSYGIVLWEVMSYGERPY 239 >3HNG-A nrPDB Length = 360 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 35/107 (32%), Positives = 57/107 (53%), Gaps = 6/107 (5%) Query: 286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIR- 343 E + Y+ ++ G+E L ++RDL NILL + ++I D GLA I + D +R Sbjct: 199 EDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRK 258 Query: 344 --GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 R+ + +MAPE + ++ Y D W G L++E+ G SP+ G Sbjct: 259 GDTRL-PLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPG 304 >5IKW-A nrPDB Length = 310 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 41/120 (34%), Positives = 58/120 (48%), Gaps = 18/120 (15%) Query: 282 GFEEERALFYAAEILCGLEDLHRENT--VYRDLKPENILLDDYGHIRISDLGLAVKI--- 336 GF E L + + LH+ T ++RDLK ENILL+D G+ + D G A Sbjct: 114 GFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLN 173 Query: 337 PEGDLIR------GRVGTVGYMAPEVLNNQRYGLSP-----DYWGLGCLIYEMIEGQSPF 385 P+ D + + T+ Y APE++N YG P D W LGCL+Y++ PF Sbjct: 174 PQKDGVNVVEEEIKKYTTLSYRAPEMIN--LYGGKPITTKADIWALGCLLYKLCFFTLPF 231 >5O0Y-A nrPDB Length = 579 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/182 (29%), Positives = 86/182 (47%), Gaps = 22/182 (12%) Query: 223 KKRKGESMALNEKQILEKVNSQFVVNL-AYAYETKDALCLVLTIMNGGDLKFHIYNMGNP 281 KK A E +I ++++ +V L Y D+ C VL G DL F++ Sbjct: 327 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 386 Query: 282 GFEEERALFYAAEILCGLEDLH--RENTVYRDLKPENILLDD---YGHIRISDLGLAVKI 336 +E R++ +I+ L+ L+ + ++ DLKP NILL + G I+I+D GL+ KI Sbjct: 387 SEKEARSII--MQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLS-KI 443 Query: 337 PEGD---------LIRGRVGTVGYMAPE--VLNNQRYGLSP--DYWGLGCLIYEMIEGQS 383 + D L GT Y+ PE V+ + +S D W +G + Y+ + G+ Sbjct: 444 MDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRK 503 Query: 384 PF 385 PF Sbjct: 504 PF 505 >4XI2-A nrPDB Length = 446 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 60/246 (24%), Positives = 111/246 (45%), Gaps = 18/246 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG G FG V + R + A K + + + E + E +++ ++ + +V L Y Sbjct: 195 LGTGQFGVVKYGKWRGQYDV-AIKMIREGSM----SEDEFIEEAKVMMNLSHEKLVQL-Y 248 Query: 252 AYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 TK ++T M G L ++ M + F+ ++ L ++ +E L + ++R Sbjct: 249 GVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLESKQFLHR 307 Query: 311 DLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGYMAPEVLNNQRYGLSPD 367 DL N L++D G +++SD GL+ + + D VG+ V + PEVL ++ D Sbjct: 308 DLAARNCLVNDQGVVKVSDFGLSRYVLD-DEYTSSVGSKFPVRWSPPEVLMYSKFSSKSD 366 Query: 368 YWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYS-HKFSEEAKSICKMLLT 425 W G L++E+ G+ P+ E+ E + + +Y H SE +I Sbjct: 367 IWAFGVLMWEIYSLGKMPY----ERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWH 422 Query: 426 KDAKQR 431 + A +R Sbjct: 423 EKADER 428 >5UNP-A nrPDB Length = 369 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 86/221 (38%), Gaps = 31/221 (14%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ------ 244 LG+G FG V C G ++ K K ++ + +N +LEK+N + Sbjct: 41 TLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEIN---VLEKINEKDPDNKN 97 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 V + ++ +C+ ++ F N P + + A ++ ++ LH Sbjct: 98 LCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLP-YPIHQVRHMAFQLCQAVKFLHD 156 Query: 305 ENTVYRDLKPENILL--DDY-----------------GHIRISDLGLAVKIPEGDLIRGR 345 + DLKPENIL DY +R+ D G A E Sbjct: 157 NKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHH--STI 214 Query: 346 VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFR 386 V T Y APEV+ + D W +GC+I+E G + F+ Sbjct: 215 VSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQ 255 >3N9X-A nrPDB Length = 432 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 88/227 (38%), Gaps = 51/227 (22%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEK--------KRIKKRKGESMALNEKQILEKVN 242 ++G+G +G V + T K A K++ + KRI L E IL ++ Sbjct: 33 LIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRI---------LREITILNRLK 83 Query: 243 SQFVVNLAYAYETKDAL-----CLVLTIMNGGDLKFHIYNMGNPGF-EEERALFYAAEIL 296 S +++ L D L +VL I + K P F EE +L Sbjct: 84 SDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKL----FKTPIFLTEEHIKTILYNLL 139 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE-------GDL-------- 341 G +H ++RDLKP N LL+ +++ D GLA I DL Sbjct: 140 LGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGP 199 Query: 342 --------IRGRVGTVGYMAPE-VLNNQRYGLSPDYWGLGCLIYEMI 379 + V T Y APE +L + Y S D W GC+ E++ Sbjct: 200 HNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >4LFI-A nrPDB Length = 374 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 33/107 (30%), Positives = 51/107 (47%), Gaps = 2/107 (1%) Query: 281 PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG-HIRISDLGLAVKIPEG 339 P + FY E+L L+ H ++RD+KP N+++D +R+ D GLA Sbjct: 167 PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN 226 Query: 340 DLIRGRVGTVGYMAPEVLNNQR-YGLSPDYWGLGCLIYEMIEGQSPF 385 RV + + PE+L + R Y S D W G ++ MI + PF Sbjct: 227 MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 273 >3G0E-A nrPDB Length = 336 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 32/101 (31%), Positives = 51/101 (50%), Gaps = 4/101 (3%) Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA--VKIPEGDLIRGRVGT 348 ++ ++ G+ L +N ++RDL NILL +I D GLA +K +++G Sbjct: 173 FSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARL 232 Query: 349 -VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 V +MAPE + N Y D W G ++E+ G SP+ G Sbjct: 233 PVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 273 >6DC0-A nrPDB Length = 292 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 80/188 (42%), Gaps = 16/188 (8%) Query: 269 GDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL--DDYGHIR 326 GD+ H Y EE A +I+ + H+ V DLK + ++ +R Sbjct: 82 GDM--HSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLR 139 Query: 327 ISDL-GLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ--RYGLSPDYWGLGCLIYEMIEGQS 383 + L + E D + + G Y++PE+LN G + D W LG ++Y ++ G+ Sbjct: 140 LESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRY 199 Query: 384 PFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVK 443 PF ++ R E S +A+ + + LL ++ +RL A E+ Sbjct: 200 PFHDSDPSALFSKIRRGQFCIPE----HISPKARCLIRSLLRREPSERL-----TAPEIL 250 Query: 444 RHPFFRNM 451 HP+F ++ Sbjct: 251 LHPWFESV 258 >5GNK-A nrPDB Length = 297 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 97/219 (44%), Gaps = 30/219 (13%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEKV 241 F++ +VLG G FG V G+ A K L + K E L+E ++ V Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAYVMASV 78 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDL----KFHIYNMGNPGFEEERALFYAAEILC 297 ++ V L T + L++ +M G L + H N+G+ + L + +I Sbjct: 79 DNPHVCRLLGICLT-STVQLIMQLMPFGCLLDYVREHKDNIGS-----QYLLNWCVQIAK 132 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI--------PEGDLIRGRVGTV 349 G+ L V+RDL N+L+ H++I+D GLA + EG G+V + Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG----GKV-PI 187 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 +MA E + ++ Y D W G ++E++ G P+ G Sbjct: 188 KWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 226 >3MY0-A nrPDB Length = 305 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 42/116 (36%), Positives = 53/116 (45%), Gaps = 21/116 (18%) Query: 283 FEEERALFYAAEILCGLEDLHRE--------NTVYRDLKPENILLDDYGHIRISDLGLAV 334 E AL A CGL LH E +RD K N+L+ I+DLGLAV Sbjct: 102 LEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAV 161 Query: 335 KIPEGD--LIRG---RVGTVGYMAPEVLNNQ-------RYGLSPDYWGLGCLIYEM 378 +G L G RVGT YMAPEVL+ Q Y + D W G +++E+ Sbjct: 162 MHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWT-DIWAFGLVLWEI 216 >5L6P-A nrPDB Length = 298 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 51/207 (24%), Positives = 97/207 (46%), Gaps = 17/207 (8%) Query: 191 VLGKGGFGEVCACQVRATGK---MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 V+G G FGEVC +++ G+ A K L+ ++++ + L+E I+ + + ++ Sbjct: 26 VIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRD--FLSEASIMGQFDHPNII 83 Query: 248 NLAYAYETKDALCLVLT--IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 L TK ++LT + N F N G F + + I G++ L Sbjct: 84 RLE-GVVTKSRPVMILTEFMENCALDSFLRLNDGQ--FTVIQLVGMLRGIAAGMKYLSEM 140 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKI---PEGDLIRGRVG---TVGYMAPEVLNN 359 N V+RDL NIL++ ++SD GL+ + P +G + + APE + Sbjct: 141 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAY 200 Query: 360 QRYGLSPDYWGLGCLIYEMIE-GQSPF 385 +++ + D W G +++E++ G+ P+ Sbjct: 201 RKFTSASDVWSYGIVMWEVMSYGERPY 227 >5CEK-A nrPDB Length = 263 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 80/188 (42%), Gaps = 16/188 (8%) Query: 269 GDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL--DDYGHIR 326 GD+ H Y EE A +I+ + H+ V DLK + ++ +R Sbjct: 85 GDM--HSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLR 142 Query: 327 ISDL-GLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ--RYGLSPDYWGLGCLIYEMIEGQS 383 + L + E D + + G Y++PE+LN G + D W LG ++Y ++ G+ Sbjct: 143 LESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRY 202 Query: 384 PFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVK 443 PF ++ R E S +A+ + + LL ++ +RL A E+ Sbjct: 203 PFHDSDPSALFSKIRRGQFCIPE----HISPKARCLIRSLLRREPSERL-----TAPEIL 253 Query: 444 RHPFFRNM 451 HP+F ++ Sbjct: 254 LHPWFESV 261 >3SXS-A nrPDB Length = 268 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 50/199 (25%), Positives = 86/199 (43%), Gaps = 13/199 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKK-RKGESMALNEKQILEKVNSQFVVNLA 250 LG G FG V GK + K IK+ E E Q + K++ +V Sbjct: 16 LGSGQFG------VVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFY 69 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 + + +V ++ G L ++ + G G E + L ++ G+ L ++R Sbjct: 70 GVCSKEYPIYIVTEYISNGCLLNYLRSHGK-GLEPSQLLEMCYDVCEGMAFLESHQFIHR 128 Query: 311 DLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGYMAPEVLNNQRYGLSPD 367 DL N L+D +++SD G+ + + + VGT V + APEV + +Y D Sbjct: 129 DLAARNCLVDRDLCVKVSDFGMTRYVLDDQYV-SSVGTKFPVKWSAPEVFHYFKYSSKSD 187 Query: 368 YWGLGCLIYEMIE-GQSPF 385 W G L++E+ G+ P+ Sbjct: 188 VWAFGILMWEVFSLGKMPY 206 >3KUL-B nrPDB Length = 325 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 48/206 (23%), Positives = 96/206 (46%), Gaps = 15/206 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKM---YACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 +++G G GEVC ++R G+ A K L+ ++++ + L+E I+ + + + Sbjct: 55 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRD--FLSEASIMGQFDHPNI 112 Query: 247 VNLAYAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 + L T+ L +++T M G L + + F + + + G+ L Sbjct: 113 IRLE-GVVTRGRLAMIVTEYMENGSLDTFLRTH-DGQFTIMQLVGMLRGVGAGMRYLSDL 170 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG-----YMAPEVLNNQ 360 V+RDL N+L+D ++SD GL+ ++ E D T G + APE + + Sbjct: 171 GYVHRDLAARNVLVDSNLVCKVSDFGLS-RVLEDDPDAAYTTTGGKIPIRWTAPEAIAFR 229 Query: 361 RYGLSPDYWGLGCLIYEMIE-GQSPF 385 + + D W G +++E++ G+ P+ Sbjct: 230 TFSSASDVWSFGVVMWEVLAYGERPY 255 >4HZS-A nrPDB Length = 341 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 49/102 (48%), Gaps = 5/102 (4%) Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD----LIRGRV 346 YA ++ G+ L + ++RDL N+LL ++I D GL +P+ D + R Sbjct: 120 YAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRK 179 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 + APE L + + + D W G ++EM GQ P+ G Sbjct: 180 VPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIG 221 >3V5Q-A nrPDB Length = 297 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 67/271 (24%), Positives = 112/271 (41%), Gaps = 31/271 (11%) Query: 190 RVLGKGGFGEV--CACQVRATGK---MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 R LG+G FG+V C + K + A K L+ + RK E ++L + + Sbjct: 21 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQ---REAELLTNLQHE 77 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDL-KF--------HIYNMGNPGFEE-----ERALF 290 +V D L +V M GDL KF I G P + + L Sbjct: 78 HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLH 137 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT-- 348 A++I G+ L ++ V+RDL N L+ ++I D G++ + D R T Sbjct: 138 IASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTML 197 Query: 349 -VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSP-FRGRKEKVKREEVDRRVLETE 405 + +M PE + +++ D W G +++E+ G+ P F+ +V RVLE Sbjct: 198 PIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERP 257 Query: 406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 V +E + ++ +QRL +E Sbjct: 258 RV----CPKEVYDVMLGCWQREPQQRLNIKE 284 >3LZB-A nrPDB Length = 327 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 96/219 (43%), Gaps = 30/219 (13%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEKV 241 F++ +VLG G FG V G+ A K L + K E L+E ++ V Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAYVMASV 74 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDL----KFHIYNMGNPGFEEERALFYAAEILC 297 ++ V L T + L+ +M G L + H N+G+ + L + +I Sbjct: 75 DNPHVCRLLGICLT-STVQLITQLMPFGCLLDYVREHKDNIGS-----QYLLNWCVQIAK 128 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI--------PEGDLIRGRVGTV 349 G+ L V+RDL N+L+ H++I+D GLA + EG G+V + Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG----GKV-PI 183 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 +MA E + ++ Y D W G ++E++ G P+ G Sbjct: 184 KWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 222 >1U54-B nrPDB Length = 291 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 49/102 (48%), Gaps = 5/102 (4%) Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD----LIRGRV 346 YA ++ G+ L + ++RDL N+LL ++I D GL +P+ D + R Sbjct: 126 YAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRK 185 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 + APE L + + + D W G ++EM GQ P+ G Sbjct: 186 VPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIG 227 >4PDO-A nrPDB Length = 299 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 96/207 (46%), Gaps = 16/207 (7%) Query: 190 RVLGKGGFGEVCACQVR-ATGKM---YACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 +V+G G FGEV ++ ++GK A K L+ +K++ + L E I+ + + Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVD--FLGEAGIMGQFSHHN 97 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 ++ L + ++ M G L KF G F + + I G++ L Sbjct: 98 IIRLEGVISKYKPMMIITEYMENGALDKFLREKDGE--FSVLQLVGMLRGIAAGMKYLAN 155 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-----LIRGRVGTVGYMAPEVLNN 359 N V+RDL NIL++ ++SD GL+ ++ E D G + + APE ++ Sbjct: 156 MNYVHRDLAARNILVNSNLVCKVSDFGLS-RVLEDDPEATYTTSGGKIPIRWTAPEAISY 214 Query: 360 QRYGLSPDYWGLGCLIYE-MIEGQSPF 385 +++ + D W G +++E M G+ P+ Sbjct: 215 RKFTSASDVWSFGIVMWEVMTYGERPY 241 >2QLU-A nrPDB Length = 314 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 33/86 (38%), Positives = 49/86 (56%), Gaps = 10/86 (11%) Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKI----PEGDLIRGRVGTVGYMAPEVL- 357 H+ + +RD K +N+LL ++D GLAV+ P GD G+VGT YMAPEVL Sbjct: 140 HKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD-THGQVGTRRYMAPEVLE 198 Query: 358 ---NNQRYG-LSPDYWGLGCLIYEMI 379 N QR L D + +G +++E++ Sbjct: 199 GAINFQRDAFLRIDMYAMGLVLWELV 224 >5WNL-A nrPDB Length = 342 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 94/212 (44%), Gaps = 14/212 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 F + +G GGFG+V + A K + R+ + L E + +E ++ Sbjct: 22 FAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMEL-LEEAKKMEMAKFRY 80 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH-- 303 ++ + Y ++ + LV+ M G L+ + + P R + E G+ LH Sbjct: 81 ILPV-YGI-CQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVH---ETAVGMNFLHCM 135 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLA----VKIPEGDLIRGRVGTVGYMAPEVL-- 357 ++ +LKP NILLD + H++ISD GLA + + G GT+ Y+ PE + Sbjct: 136 SPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIRE 195 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRK 389 ++ + D + +I+ ++ + PF K Sbjct: 196 KSRLFDTKHDVYSFAIVIWGVLTQKKPFADEK 227 >3NIE-A nrPDB Length = 429 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 91/232 (39%), Gaps = 58/232 (25%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEK--------KRIKKRKGESMALNEKQILEKVN 242 ++G+G +G V + K A K++ + KRI L E IL ++ Sbjct: 35 LIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRI---------LREITILNRLK 85 Query: 243 SQFVVNLAYAYETKDAL-----CLVLTIMNGGDLKFHIYNMGNPGFEEE---RALFYAAE 294 S +++ L +D L +VL I + K P F E + + Y Sbjct: 86 SDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKL----FKTPIFLTEQHVKTILY--N 139 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE-------GDL------ 341 +L G + +H ++RDLKP N LL+ ++I D GLA I DL Sbjct: 140 LLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEEN 199 Query: 342 -------------IRGRVGTVGYMAPE-VLNNQRYGLSPDYWGLGCLIYEMI 379 + V T Y APE +L + Y S D W GC+ E++ Sbjct: 200 EEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 >5MJB-A nrPDB Length = 305 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 48/206 (23%), Positives = 94/206 (45%), Gaps = 15/206 (7%) Query: 191 VLGKGGFGEVCACQVRATGK---MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 V+G G FGEV +++ GK A K L+ +K++ + L+E I+ + + + ++ Sbjct: 33 VIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRD--FLSEASIMGQFDHRNII 90 Query: 248 NLAYAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 L + ++ M L F N G F + + I G++ L N Sbjct: 91 RLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQ--FTVIQLVGMLRGIAAGMKYLSEMN 148 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG------YMAPEVLNNQ 360 V+RDL NIL++ ++SD GL+ + + ++G + APE + + Sbjct: 149 YVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYR 208 Query: 361 RYGLSPDYWGLGCLIYEMIE-GQSPF 385 ++ + D W G +++E++ G+ P+ Sbjct: 209 KFTSASDVWSYGIVMWEVMSFGERPY 234 >5AR8-A nrPDB Length = 326 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 80/215 (37%), Gaps = 26/215 (12%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 R L +G G V + + A K L L E +IL K +++ + Sbjct: 38 RYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPI 97 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGN-PGFEEERALFYAAEILCGLEDLHREN-- 306 + L +V M G L ++ P EI G+ LH Sbjct: 98 LGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPP 157 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLA-------------VKIPEGDLIRGRVGTVGYMA 353 ++ DLK +NILLD+ H++I+D GL+ PEG GT+ YM Sbjct: 158 LLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEG-------GTIIYMP 210 Query: 354 PEVL---NNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 PE R + D + + +E++ + PF Sbjct: 211 PENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPF 245 >3LMG-A nrPDB Length = 344 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 47/211 (22%), Positives = 92/211 (43%), Gaps = 10/211 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATG---KMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 R+ +VLG G FG V G K+ C ++ + + ++ +++ + + ++ Sbjct: 33 LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVT-DHMLAIGSLD 91 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +V L +L LV + G L H+ + L + +I G+ L Sbjct: 92 HAHIVRL-LGLCPGSSLQLVTQYLPLGSLLDHVRQHRG-ALGPQLLLNWGVQIAKGMYYL 149 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD--LIRGRVGT-VGYMAPEVLNN 359 V+R+L N+LL ++++D G+A +P D L+ T + +MA E ++ Sbjct: 150 EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHF 209 Query: 360 QRYGLSPDYWGLGCLIYEMIE-GQSPFRGRK 389 +Y D W G ++E++ G P+ G + Sbjct: 210 GKYTHQSDVWSYGVTVWELMTFGAEPYAGLR 240 >4BTK-A nrPDB Length = 337 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 99/237 (41%), Gaps = 20/237 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V K+ ++ + +G GGFGE+ T + A K ++ K+ + E +L+K Sbjct: 53 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQ-----VLKMEVAVLKK 107 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + + V + V+ + G +L + F L +IL +E Sbjct: 108 LQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIE 167 Query: 301 DLHRENTVYRDLKPENILL----DDYGHIRISDLGLAVKIPE--GDL-----IRGRVGTV 349 +H ++RD+KP N + Y + D GLA + GD+ + G GTV Sbjct: 168 AIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTV 227 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK----VKREEVDRRVL 402 Y + N+ G D W L ++ E GQ P+R K+K + +E+ + R+L Sbjct: 228 RYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRML 284 >4NFN-A nrPDB Length = 309 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 99/237 (41%), Gaps = 20/237 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V K+ ++ + +G GGFGE+ T + A K ++ K+ + E +L+K Sbjct: 18 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQ-----VLKMEVAVLKK 72 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + + V + V+ + G +L + F L +IL +E Sbjct: 73 LQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIE 132 Query: 301 DLHRENTVYRDLKPENILL----DDYGHIRISDLGLAVKIPE--GDL-----IRGRVGTV 349 +H ++RD+KP N + Y + D GLA + GD+ + G GTV Sbjct: 133 AIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTV 192 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK----VKREEVDRRVL 402 Y + N+ G D W L ++ E GQ P+R K+K + +E+ + R+L Sbjct: 193 RYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRML 249 >5XD6-A nrPDB Length = 305 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 98/229 (42%), Gaps = 33/229 (14%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 E + +T N + ++G+G +G V ++ +GK A K+L+ + + + L + Sbjct: 16 ELRDITDN-YGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSK----QPDQEFLAQVS 69 Query: 237 ILEKVNSQFVVNL------------AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG-- 282 ++ ++ + VV L AY Y +L +L G PG Sbjct: 70 MVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKG-------VKGAQPGPV 122 Query: 283 FEEERALFYAAEILCGLEDLHRE---NTVYRDLKPENILLDDYGHIRISDLGLAVKIPE- 338 + + A GLE LH + + ++RD+K N+LL D +I+D L+ + P+ Sbjct: 123 LSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDM 182 Query: 339 -GDLIRGRV-GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 L RV GT GY APE D + G ++ E++ G+ P Sbjct: 183 AARLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPV 231 >5VDK-A nrPDB Length = 297 Score = 48.9 bits (115), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 74/292 (25%), Positives = 113/292 (38%), Gaps = 44/292 (15%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ- 244 F + +G G FG V C R G +YA KR K + E+ AL+E + Sbjct: 17 FLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHAVLGHHP 75 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG--FEEERALFYAAEILCGLEDL 302 VV ++ D + + NGG L+ I G FEE + +I GL + Sbjct: 76 HVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYI 135 Query: 303 HRENTVYRDLKPENILL------DDYGHI-----------------RISDLGLAVKIPEG 339 H + V+ D+KP NI + + G I +I DLG A I + Sbjct: 136 HNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKP 195 Query: 340 DLIRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQS-PFRGRKEKVKREEV 397 + G ++A E+L + R+ D + LG I +S P G R+ Sbjct: 196 KV---EEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGN 252 Query: 398 DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 V + + SE S+ K ++ DA+QR AA + R+ R Sbjct: 253 FPDVPQ-------ELSESFSSLLKNMIQPDAEQR-----PSAAALARNTVLR 292 >2PZI-A nrPDB Length = 681 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/155 (28%), Positives = 70/155 (45%), Gaps = 15/155 (9%) Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG 347 A+ Y EIL L LH VY DLKPENI+L + +++ DLG +I + G Sbjct: 184 AIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYL---YG 239 Query: 348 TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 T G+ APE++ ++ D + +G + + GR E D VL+T + Sbjct: 240 TPGFQAPEIVRTGPT-VATDIYTVGRTLAALTLDLPTRNGRYVDGLPE--DDPVLKTYDS 296 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEV 442 Y + + + D +QR EE +A++ Sbjct: 297 YGR--------LLRRAIDPDPRQRFTTAEEMSAQL 323 >4LRM-A nrPDB Length = 334 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 95/218 (43%), Gaps = 25/218 (11%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEKV 241 F++ +VLG G FG V G+ A K L + K E L+E ++ V Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAYVMASV 78 Query: 242 NSQ---FVVNLAYAYETKDALCLVLTIMNGGDL----KFHIYNMGNPGFEEERALFYAAE 294 ++ V L T + L+ +M G L + H N+G+ + L + + Sbjct: 79 DNPGNPHVCRLLGICLT-STVQLITQLMPFGCLLDYVREHKDNIGS-----QYLLNWCVQ 132 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI----PEGDLIRGRVGTVG 350 I G+ L V+RDL N+L+ H++I+D GLA + E G+V + Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKV-PIK 191 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 +MA E + ++ Y D W G ++E++ G P+ G Sbjct: 192 WMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG 229 >3EB0-A nrPDB Length = 383 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 2/100 (2%) Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH-IRISDLGLAVKIPEGDLIRGRVGT 348 Y ++ + +H +RD+KP+N+L++ + +++ D G A K+ + + + Sbjct: 145 IYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICS 204 Query: 349 VGYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 Y APE+ L Y S D W +GC+ E+I G+ F G Sbjct: 205 RFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSG 244 Score = 32.7 bits (73), Expect = 0.41, Method: Compositional matrix adjust. Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 8/69 (11%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKR-LEKKRIKKRKGESMALNEKQILEKVNSQFVVN 248 + LG G FG VC +GK +A K+ L+ R K R+ + M ++L+ VN +V+ Sbjct: 13 KTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDIM-----KVLDHVNIIKLVD 67 Query: 249 LAYAYETKD 257 Y Y T D Sbjct: 68 --YFYTTGD 74 >5KMM-A nrPDB Length = 329 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 90/216 (41%), Gaps = 25/216 (11%) Query: 192 LGKGGFGEV----CACQVRATGKMY-ACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 LG+G FG+V C + KM A K L++ R+ E ++L + Q + Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ---REAELLTMLQHQHI 99 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG------------NPG-FEEERALFYAA 293 V L +V M GDL + + G PG + L A+ Sbjct: 100 VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS 159 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR--GRVGT-VG 350 ++ G+ L + V+RDL N L+ ++I D G++ I D R GR + Sbjct: 160 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 219 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPF 385 +M PE + +++ D W G +++E+ G+ P+ Sbjct: 220 WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPW 255 >4Y12-A nrPDB Length = 375 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/155 (28%), Positives = 70/155 (45%), Gaps = 15/155 (9%) Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG 347 A+ Y EIL L LH VY DLKPENI+L + +++ DLG +I + G Sbjct: 223 AIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYL---YG 278 Query: 348 TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 T G+ APE++ ++ D + +G + + GR E D VL+T + Sbjct: 279 TPGFQAPEIVRTGPT-VATDIYTVGRTLAALTLDLPTRNGRYVDGLPE--DDPVLKTYDS 335 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEV 442 Y + + + D +QR EE +A++ Sbjct: 336 YGR--------LLRRAIDPDPRQRFTTAEEMSAQL 362 >2CMW-A nrPDB Length = 310 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 15/135 (11%) Query: 275 IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH-----IRISD 329 ++++ + F + L A ++L +E +H +N +YRD+KPEN L+ G+ I I D Sbjct: 86 LFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIID 145 Query: 330 LGLAVK---------IPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE 380 GLA + IP + + GT YM+ + D LG + + Sbjct: 146 FGLAKEYIDPETKKHIPYREH-KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 204 Query: 381 GQSPFRGRKEKVKRE 395 G P++G K +E Sbjct: 205 GSLPWQGLKADTLKE 219 >5DMZ-A nrPDB Length = 365 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 52/105 (49%), Gaps = 14/105 (13%) Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILL-----------DDYGHIRISDLGLAVKI--- 336 +A +L +E +H ++ D+KP+N +L D + + DLG ++ + Sbjct: 177 FAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLF 236 Query: 337 PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEG 381 P+G + + T G+ E+L+N+ + DY+G+ +Y M+ G Sbjct: 237 PKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFG 281 >1PY5-A nrPDB Length = 326 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 68/212 (32%), Positives = 90/212 (42%), Gaps = 36/212 (16%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +GKG FGEV + R G+ A K I + E E +I + V + L + Sbjct: 37 IGKGRFGEVWRGKWR--GEEVAVK------IFSSREERSWFREAEIYQTVMLRHENILGF 88 Query: 252 -AYETKD-----ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 A + KD L LV G L F N E L A GL LH E Sbjct: 89 IAADNKDNGTWTQLWLVSDYHEHGSL-FDYLNRYTVTVEGMIKL--ALSTASGLAHLHME 145 Query: 306 --------NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLI----RGRVGTVGYM 352 +RDLK +NIL+ G I+DLGLAV+ D I RVGT YM Sbjct: 146 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 205 Query: 353 APEVLN---NQRYGLS---PDYWGLGCLIYEM 378 APEVL+ N ++ S D + +G + +E+ Sbjct: 206 APEVLDDSINMKHFESFKRADIYAMGLVFWEI 237 >4L68-A nrPDB Length = 340 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 38/121 (31%), Positives = 56/121 (46%), Gaps = 14/121 (11%) Query: 298 GLEDLH---RENTVYRDLKPENILLDDYGHIRISDLGLA-VKIP----EGDLIRGRVGTV 349 GL LH R +++++ IL+D+ RI D GLA + +P E + G +G Sbjct: 148 GLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEF 207 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK------VKREEVDRRVLE 403 GY+APE L D +GLG ++ E+ G G K VK+ E R+ E Sbjct: 208 GYVAPEYSTTMLASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAE 267 Query: 404 T 404 T Sbjct: 268 T 268 >3Q4U-A nrPDB Length = 301 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 83/207 (40%), Gaps = 26/207 (12%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +GKG +GEV + G+ A K + K E+ N + + F+ + Sbjct: 16 VGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMT 73 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE------ 305 + + L L+ G L + + + L I GL LH E Sbjct: 74 SRHSSTQLWLITHYHEMGSLYDY---LQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQG 130 Query: 306 --NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG--DLIRG---RVGTVGYMAPEVLN 358 +RDLK +NIL+ G I+DLGLAV + L G RVGT YMAPEVL+ Sbjct: 131 KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLD 190 Query: 359 N-------QRYGLSPDYWGLGCLIYEM 378 Y D W G +++E+ Sbjct: 191 ETIQVDCFDSYK-RVDIWAFGLVLWEV 216 >5X18-A nrPDB Length = 295 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 51/223 (22%), Positives = 96/223 (43%), Gaps = 23/223 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G FG + G A K + RK E+ L ++ K+ + N+ Y Sbjct: 15 IGEGSFGVLFEGTNMINGVPVAIK------FEPRKTEAPQLRDEYKTYKILNG-TPNIPY 67 Query: 252 AYE-TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 AY ++ L +L I G +++ F + + A +++ +EDLH + +YR Sbjct: 68 AYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYR 127 Query: 311 DLKPENILLD-----DYGHIRISDLGLAVK---------IPEGDLIRGRVGTVGYMAPEV 356 D+KP+N L+ D +I + D G+A + IP + + GT YM+ Sbjct: 128 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREK-KSLSGTARYMSINT 186 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 + D LG + + + G P++G K +++ ++ Sbjct: 187 HLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEK 229 >2Y4I-B nrPDB Length = 319 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 98/217 (45%), Gaps = 33/217 (15%) Query: 191 VLGKGGFGEVCACQVRA--TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVN 248 ++GKG FG+V + ++ +R + ++K K E MA + + + VV Sbjct: 40 LIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTR------HENVVL 93 Query: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV 308 A + L ++ ++ G L + + + + A EI+ G+ LH + + Sbjct: 94 FMGACMSPPHLAIITSLCKGRTL-YSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGIL 152 Query: 309 YRDLKPENILLDDYGHIRISDLGL---AVKIPEG---DLIRGRVGTVGYMAPEVLNNQRY 362 ++DLK +N+ D+ G + I+D GL + + G D +R + G + ++APE++ Sbjct: 153 HKDLKSKNVFYDN-GKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ--- 208 Query: 363 GLSP-------------DYWGLGCLIYEMIEGQSPFR 386 LSP D + LG + YE+ + PF+ Sbjct: 209 -LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK 244 >3MDY-A nrPDB Length = 337 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 21/116 (18%) Query: 283 FEEERALFYAAEILCGLEDLHRE--------NTVYRDLKPENILLDDYGHIRISDLGLAV 334 + + L A + GL LH E +RDLK +NIL+ G I+DLGLAV Sbjct: 131 LDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV 190 Query: 335 K-IPEGDLI----RGRVGTVGYMAPEVLNN-------QRYGLSPDYWGLGCLIYEM 378 K I + + + RVGT YM PEVL+ Q Y ++ D + G +++E+ Sbjct: 191 KFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMA-DMYSFGLILWEV 245 >5E8V-A nrPDB Length = 316 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 35/216 (16%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMAL--NEKQILEKVN--SQFV 246 ++GKG F EV +A K ++ E +K E A EK I +N + + Sbjct: 16 LVGKGRFAEV----YKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENI 71 Query: 247 VNLAYAYETKDAL----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 + A E K L L+ G+L+ ++ +E+ R L + + G+ L Sbjct: 72 LQFLTAEERKTELGKQYWLITAFHAKGNLQEYL-TRHVISWEDLRKL--GSSLARGIAHL 128 Query: 303 HRENT---------VYRDLKPENILLDDYGHIRISDLGLAVKI----PEGDLIR-GRVGT 348 H ++T V+RDLK NIL+ + + D GL++++ DL G+VGT Sbjct: 129 HSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGT 188 Query: 349 VGYMAPEV------LNNQRYGLSPDYWGLGCLIYEM 378 YMAPEV L N D + + +++EM Sbjct: 189 ARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEM 224 >2C47-A nrPDB Length = 313 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 61/256 (23%), Positives = 107/256 (41%), Gaps = 25/256 (9%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 FR + +G G FGE+ + T + Y +LE IK R + L + + ++ Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNE-YVAIKLEP--IKSR-APQLHLEYRFYKQLSATEG 61 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 V + Y +VL ++ G L+ ++++ + F + L A +++ +E +H + Sbjct: 62 VPQVYYFGPCGKYNAMVLELL-GPSLE-DLFDLCDRTFTLKTVLMIAIQLITRMEYVHTK 119 Query: 306 NTVYRDLKPENILLDDYG-----HIRISDLGLAVK---------IPEGDLIRGRVGTVGY 351 + +YRD+KPEN L+ G I I D GLA + IP + + GT Y Sbjct: 120 SLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREH-KSLTGTARY 178 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEV----DRRVLETEEV 407 M+ + D LG + + G P++G K +E D + EV Sbjct: 179 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 238 Query: 408 YSHKFSEEAKSICKML 423 F EE + + + Sbjct: 239 LCENFPEEMATYLRYV 254 >3G2F-A nrPDB Length = 336 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 31/94 (32%), Positives = 47/94 (50%), Gaps = 16/94 (17%) Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR---------GRVGTVGY 351 D ++ +RDL N+L+ + G ISD GL++++ L+R VGT+ Y Sbjct: 135 DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRY 194 Query: 352 MAPEVLN---NQRYGLSP----DYWGLGCLIYEM 378 MAPEVL N R S D + LG + +E+ Sbjct: 195 MAPEVLEGAVNLRDCESALKQVDMYALGLIYWEI 228 >4NT4-A nrPDB Length = 312 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 13/134 (9%) Query: 275 IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH-----IRISD 329 ++N+ F + L A ++L +E +H + +YRD+KPEN L+ I I D Sbjct: 103 LFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIID 162 Query: 330 LGLAVKIPEGDLIR--------GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEG 381 GLA + + D R GT YM+ + D LG + + G Sbjct: 163 FGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRG 222 Query: 382 QSPFRGRKEKVKRE 395 P++G K +E Sbjct: 223 SLPWQGLKADTLKE 236 >4XHH-A nrPDB Length = 403 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/229 (22%), Positives = 99/229 (43%), Gaps = 18/229 (7%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 FR R +G G FG++ +G+ A RLE R + + + + K + V F Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYKYLSGGVGIPF 67 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 + E +V+ ++ G L+ ++N + F + + A +++C ++ +H Sbjct: 68 IRWFGREGEYN---AMVIDLL-GPSLE-DLFNYCHRKFSFKTVIMLALQMICRVQYIHGR 122 Query: 306 NTVYRDLKPENILLD---DYGHIRISDLGLAVKIPEGDLIR--------GRVGTVGYMAP 354 + ++RD+KP+N L+ + + D GL+ K + + R GT Y + Sbjct: 123 SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASV 182 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 D LG ++ +G P++G K K+++ D R+LE Sbjct: 183 NTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYD-RILE 230 >3SV0-A nrPDB Length = 483 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 60/263 (22%), Positives = 110/263 (41%), Gaps = 28/263 (10%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 +P N FR R +G G FGE+ T + A K LE + K L E +I Sbjct: 2 EPRVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTK----HPQLLYESKIY 56 Query: 239 EKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + + N+ + D LV+ ++ G L+ ++N + + L A +++ Sbjct: 57 RILQGGTGIPNVRWFGVEGDYNVLVMDLL-GPSLE-DLFNFCSRKLSLKTVLMLADQMIN 114 Query: 298 GLEDLHRENTVYRDLKPENILLD---DYGHIRISDLGLAVK---------IPEGDLIRGR 345 +E +H ++ ++RD+KP+N L+ + I D GLA K IP + + Sbjct: 115 RVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRE-NKNL 173 Query: 346 VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE 405 GT Y + D LG ++ + G P++G K K+++ E Sbjct: 174 TGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKY-------E 226 Query: 406 EVYSHKFSEEAKSICKMLLTKDA 428 ++ K + +++C+ T+ A Sbjct: 227 KISEKKVATSIEALCRGYPTEFA 249 >2CHL-A nrPDB Length = 351 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 60/135 (44%), Gaps = 15/135 (11%) Query: 275 IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH-----IRISD 329 ++++ + F + L A +++ +E +H +N +YRD+KPEN L+ G+ I I D Sbjct: 115 LFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIID 174 Query: 330 LGLAVK---------IPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE 380 LA + IP + + GT YM+ + D LG + + Sbjct: 175 FALAKEYIDPETKKHIPYREH-KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLR 233 Query: 381 GQSPFRGRKEKVKRE 395 G P++G K +E Sbjct: 234 GSLPWQGLKADTLKE 248 >6EQI-C nrPDB Length = 433 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 18/113 (15%) Query: 298 GLEDLHRENTVYRDLKPENILL-----DDYGHIRISDLGL-------AVKIPEGDLIRGR 345 + ++ N +RDLK +NIL+ D Y I I+D G + IP + + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 346 VGTVGYMAPEVLNNQRYGLS------PDYWGLGCLIYEMIEGQSPFRGRKEKV 392 G MAPE+ N + S D W +G + YE+ +PF + K+ Sbjct: 239 GGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKL 291 >4TN6-A nrPDB Length = 318 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 60/250 (24%), Positives = 104/250 (41%), Gaps = 26/250 (10%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 N +R R +G G FG++ A G+ A K LE K K + + K Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LE---CVKTKHPQLHIESKIYKMMQGG 62 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + + + D +V+ ++ G L+ ++N + F + L A +++ +E +H Sbjct: 63 VGIPTIRWCGAEGDYNVMVMELL-GPSLE-DLFNFCSRKFSLKTVLLLADQMISRIEYIH 120 Query: 304 RENTVYRDLKPENIL--LDDYGH-IRISDLGLAVK---------IPEGDLIRGRVGTVGY 351 +N ++RD+KP+N L L G+ + I D GLA K IP + + GT Y Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRE-NKNLTGTARY 179 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 + D LG ++ G P++G K KR++ +R + K Sbjct: 180 ASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYER-------ISEKK 232 Query: 412 FSEEAKSICK 421 S + +CK Sbjct: 233 MSTPIEVLCK 242 >4XHL-A nrPDB Length = 394 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 48/225 (21%), Positives = 95/225 (42%), Gaps = 17/225 (7%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 FR R +G G FG++ +G+ A RLE R + + + + + + V F Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYRYLSGGVGIPF 67 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 + E +V+ ++ G L+ ++N + F + + A ++ C ++ +H Sbjct: 68 IRWFGREGEYN---AMVIDLL-GPSLE-DLFNYCHRRFSFKTVIMLALQMFCRIQYIHGR 122 Query: 306 NTVYRDLKPENILLD---DYGHIRISDLGLAVKIPEGDLIR--------GRVGTVGYMAP 354 + ++RD+KP+N L+ + + D GL+ K + + R GT Y + Sbjct: 123 SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASV 182 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 D LG ++ +G P++G K K+++ DR Sbjct: 183 NTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDR 227 >5VC6-A nrPDB Length = 289 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 67/270 (24%), Positives = 104/270 (38%), Gaps = 35/270 (12%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ- 244 F + +G G FG V C R G +YA KR KK + E AL E + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKR-SKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHI---YNMGNPGFEEERALFYAAEILCGLED 301 VV A+ D + + NGG L I Y + + F+E ++ GL Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSY-FKEAELKDLLLQVGRGLRY 130 Query: 302 LHRENTVYRDLKPENILL---------------DDYGH----IRISDLGLAVKIPEGDLI 342 +H + V+ D+KP NI + DD+ +I DLG +I + Sbjct: 131 IHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQV- 189 Query: 343 RGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV 401 G ++A EVL N + D + L + G P R E R+ Sbjct: 190 --EEGDSRFLANEVLQENYTHLPKADIFALALTVV-CAAGAEPL-PRNGDQWHEIRQGRL 245 Query: 402 LETEEVYSHKFSEEAKSICKMLLTKDAKQR 431 +V S +F+E + K+++ D ++R Sbjct: 246 PRIPQVLSQEFTE----LLKVMIHPDPERR 271 >4F9B-A nrPDB Length = 361 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 57/251 (22%), Positives = 91/251 (36%), Gaps = 53/251 (21%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYAC--KRLEKKRIKKRKGESMA 231 K E P N F+ +G+G F V AT ++ +++ K + Sbjct: 11 KLYEAVPQLSNVFKIEDKIGEGTFSSV----YLATAQLQVGPEEKIALKHLIPTSHPIRI 66 Query: 232 LNEKQILEKVNSQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF 290 E Q L Q V+ + Y + D + + + + I N + F+E R Sbjct: 67 AAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESF-LDILN--SLSFQEVRE-- 121 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENIL----LDDYGHIRISDLGLA------------- 333 Y + L+ +H+ V+RD+KP N L L Y + D GLA Sbjct: 122 YMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALV---DFGLAQGTHDTKIELLKF 178 Query: 334 ----------------VKIPEGDLIRGRVGTVGYMAPEVLN---NQRYGLSPDYWGLGCL 374 + + + R GT G+ APEVL NQ + D W G + Sbjct: 179 VQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAI--DMWSAGVI 236 Query: 375 IYEMIEGQSPF 385 ++ G+ PF Sbjct: 237 FLSLLSGRYPF 247 >5OAT-A nrPDB Length = 411 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/107 (26%), Positives = 45/107 (42%), Gaps = 17/107 (15%) Query: 298 GLEDLHRENTVYRDLKPENILLD----DYGHIRISDLGL-------AVKIPEGDLIRGRV 346 G+ + +RDLK +N+LLD + + ISD G + +P + Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKG 224 Query: 347 GTVGYMAPEVLNNQRYGLS------PDYWGLGCLIYEMIEGQSPFRG 387 G MAPE++ + S D W +G + YE+ +PF G Sbjct: 225 GNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYG 271 >5FQD-C nrPDB Length = 341 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 54/254 (21%), Positives = 108/254 (42%), Gaps = 28/254 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + ++ R +G G FG++ G+ A K LE ++ + L E ++ + Sbjct: 16 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKAR----HPQLLYESKLYKI 70 Query: 241 VNSQFVV-NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + + ++ + + KD LV+ ++ G L+ ++N + F + L A +++ + Sbjct: 71 LQGGVGIPHIRWYGQEKDYNVLVMDLL-GPSLE-DLFNFCSRRFTMKTVLMLADQMISRI 128 Query: 300 EDLHRENTVYRDLKPENILLDDYGH---IRISDLGLAVK---------IPEGDLIRGRVG 347 E +H +N ++RD+KP+N L+ H + + D GLA K IP + + G Sbjct: 129 EYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYRE-DKNLTG 187 Query: 348 TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 T Y + D LG ++ P++G K K+++ E++ Sbjct: 188 TARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKY-------EKI 240 Query: 408 YSHKFSEEAKSICK 421 K S + +CK Sbjct: 241 SEKKMSTPVEVLCK 254 >5CLR-A nrPDB Length = 451 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 6/100 (6%) Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN 358 ++ H ++RDLKP NI+LD + D G + E GT Y+APE+ Sbjct: 189 VKQFHELGLIHRDLKPGNIMLDADMQCHLVDFGSSSSDKEPK--PASWGTASYLAPELNA 246 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD 398 + + L L Y + E +PFR +VK +VD Sbjct: 247 QEDFIAFSQVSDLFALAYSLDELFNPFR----QVKFAKVD 282 >6J6I-B nrPDB Length = 351 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 9/81 (11%) Query: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV------GTVGYMAPEVLNNQR 361 ++RD+KP ++ LD ++SDL ++ +PEG + R+ GT GY+ P Sbjct: 188 IHRDVKPMHVFLDKNWTAKLSDLSFSISLPEG---KSRIEAEWVLGTFGYIDPLYHKTCF 244 Query: 362 YGLSPDYWGLGCLIYEMIEGQ 382 D + G + +I G+ Sbjct: 245 VTEYTDVYSFGICLLVIITGK 265 >1CSN-A nrPDB Length = 298 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 28/122 (22%), Positives = 54/122 (44%), Gaps = 15/122 (12%) Query: 292 AAEILCGLEDLHRENTVYRDLKPENILL-----DDYGHIRISDLGLAVKIPEGDLIRGRV 346 A ++L ++ +H ++ VYRD+KP+N L+ + I + D G+ VK + + + Sbjct: 112 AKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGM-VKFYRDPVTKQHI 170 Query: 347 ---------GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEV 397 GT YM+ + D LG + + G P++G K +++ Sbjct: 171 PYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKY 230 Query: 398 DR 399 +R Sbjct: 231 ER 232 >3REP-A nrPDB Length = 271 Score = 37.4 bits (85), Expect = 0.019, Method: Compositional matrix adjust. Identities = 34/136 (25%), Positives = 63/136 (46%), Gaps = 19/136 (13%) Query: 260 CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR-ENTVYRD-LKPENI 317 L+ M G L ++ N ++ +A+ +A ++ G+ LH E + R L ++ Sbjct: 85 TLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSV 144 Query: 318 LLDDYGHIRIS--DLGLAVKIPEGDLIRGRVGTVGYMAPEVL------NNQRYGLSPDYW 369 ++D+ RIS D+ + + P GR+ ++APE L N+R S D W Sbjct: 145 MIDEDMTARISMADVKFSFQSP------GRMYAPAWVAPEALQKKPEDTNRR---SADMW 195 Query: 370 GLGCLIYEMIEGQSPF 385 L++E++ + PF Sbjct: 196 SFAVLLWELVTREVPF 211 >2X7G-A nrPDB Length = 389 Score = 37.0 bits (84), Expect = 0.025, Method: Compositional matrix adjust. Identities = 60/258 (23%), Positives = 93/258 (36%), Gaps = 63/258 (24%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV---- 241 + R LG G F V C GK + ++ K + AL+E ++L+ V Sbjct: 33 YHVIRKLGWGHFSTVWLCW-DMQGKRFVAMKVVKS---AQHYTETALDEIKLLKCVRESD 88 Query: 242 ----NSQFVVNLAYAYETKDA----LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 N VV L ++ +C+V ++ LK+ I G Sbjct: 89 PSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKW-IIKSNYQGLPVRCVKSIIR 147 Query: 294 EILCGLEDLHRE-NTVYRDLKPENILL--DDYGHIRISD-------------LGLAVKI- 336 ++L GL+ LH + ++ D+KPENIL+ DD R++ G AV Sbjct: 148 QVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTA 207 Query: 337 PEGDL------------IRGRVGTVG-----------------YMAPEVLNNQRYGLSPD 367 P DL IR ++ +G Y + EVL Y D Sbjct: 208 PAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPAD 267 Query: 368 YWGLGCLIYEMIEGQSPF 385 W C+ +E+ G F Sbjct: 268 IWSTACMAFELATGDYLF 285 >4I94-A nrPDB Length = 300 Score = 35.8 bits (81), Expect = 0.051, Method: Compositional matrix adjust. Identities = 41/185 (22%), Positives = 75/185 (40%), Gaps = 8/185 (4%) Query: 202 ACQVRATGKMYACKRLEKKRIKKRK--GESMALNEKQILEKVNSQFVVNL-AYAYETKDA 258 A V GK+ +R+ KR ++ L E + + ++ + + NL YE ++ Sbjct: 41 APNVVYKGKLENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEER 100 Query: 259 LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED-LHRENTVYRDLKPENI 317 L L+ M L H+++ + + L A I LE + +Y DL + Sbjct: 101 L-LIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 318 LLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYE 377 L DD + R+S GL +G + + + PE L R + G L+ + Sbjct: 160 LFDDDANPRLSCFGLMKNSRDG---KSYSTNLAFTPPEYLRTGRVTPESVIYSFGTLLLD 216 Query: 378 MIEGQ 382 ++ G+ Sbjct: 217 LLSGK 221 >4JRN-A nrPDB Length = 372 Score = 35.8 bits (81), Expect = 0.060, Method: Compositional matrix adjust. Identities = 23/91 (25%), Positives = 42/91 (46%), Gaps = 6/91 (6%) Query: 289 LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT 348 ++ +++ + + ++ + V+ D+KP N LL G + + D G +I + + +GT Sbjct: 205 MYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG-TYRI--NNSVGRAIGT 261 Query: 349 VGYMAPE---VLNNQRYGLSPDYWGLGCLIY 376 GY PE Y D W LG +Y Sbjct: 262 PGYEPPERPFQATGITYTFPTDAWQLGITLY 292 >2RSV-A nrPDB Length = 403 Score = 35.0 bits (79), Expect = 0.080, Method: Compositional matrix adjust. Identities = 37/132 (28%), Positives = 59/132 (44%), Gaps = 19/132 (14%) Query: 268 GGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLD--DYGHI 325 G DL+ IY F + L + IL LE +H V+ D+K N+LL+ + + Sbjct: 142 GSDLQ-KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 200 Query: 326 RISDLGLAVKI-PEG-------DLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG----LGC 373 + D GLA + PEG D R GT+ + + + N G++P G LG Sbjct: 201 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN----GVAPSRRGDLEILGY 256 Query: 374 LIYEMIEGQSPF 385 + + + G P+ Sbjct: 257 CMIQWLTGHLPW 268 >4O1O-A nrPDB Length = 717 Score = 35.0 bits (79), Expect = 0.10, Method: Compositional matrix adjust. Identities = 17/58 (29%), Positives = 31/58 (53%) Query: 281 PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE 338 P E+E A + + + +LHR ++DL+P+NIL+D ++D ++K E Sbjct: 437 PNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAE 494 >2LAV-A nrPDB Length = 361 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 37/132 (28%), Positives = 59/132 (44%), Gaps = 19/132 (14%) Query: 268 GGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLD--DYGHI 325 G DL+ IY F + L + IL LE +H V+ D+K N+LL+ + + Sbjct: 135 GSDLQ-KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 Query: 326 RISDLGLAVKI-PEG-------DLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG----LGC 373 + D GLA + PEG D R GT+ + + + N G++P G LG Sbjct: 194 YLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN----GVAPSRRGDLEILGY 249 Query: 374 LIYEMIEGQSPF 385 + + + G P+ Sbjct: 250 CMIQWLTGHLPW 261 >4CYJ-A nrPDB Length = 438 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 15/141 (10%) Query: 200 VCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKD-- 257 V Q G+ YA +RLE R+ K LN + +K+ + +V + + T++ Sbjct: 71 VYKAQNSRNGRHYALRRLEGYRLTNEKA---ILNVMKDWKKIKNASIVTIHEVFTTREFG 127 Query: 258 --ALCLVLTIMN-GGDLKFHIYN--MGN-----PGFEEERALFYAAEILCGLEDLHRENT 307 +L L+ H + GN P E Y +I L+ +H Sbjct: 128 DSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRL 187 Query: 308 VYRDLKPENILLDDYGHIRIS 328 R L+P I+L D IR+S Sbjct: 188 AARCLEPSKIILTDINRIRLS 208 >1R6K-A nrPDB Length = 207 Score = 34.3 bits (77), Expect = 0.16, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 10/135 (7%) Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNN 359 D+H+ ++ ++ E++LL + +S +GL V P +G M E L Sbjct: 31 DIHKHIMHWKCIRLESVLLHKAKQMGLSHIGLQVVPPLTVSETKGHNAIEMQMHLESLAK 90 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFR-----GRKEKVKREEVDRRVLETEEVYSHKFSE 414 +YG+ P W L YEM P R G +VK + + V+E V++H + + Sbjct: 91 TQYGVEP--WTLQDTSYEMWL-TPPKRCFKKQGNTVEVKFDGCEDNVMEY-VVWTHIYLQ 146 Query: 415 EAKSICKMLLTKDAK 429 + S K+ + DAK Sbjct: 147 DNDSWVKVTSSVDAK 161 >4IX6-A nrPDB Length = 350 Score = 32.7 bits (73), Expect = 0.45, Method: Compositional matrix adjust. Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 5/50 (10%) Query: 294 EILCGLEDLHRENTVYRDLKPENILL--DDYGHIRISDLG---LAVKIPE 338 E+L L LH V+RD+KP N++ D G +++ DLG L + +PE Sbjct: 151 ELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPE 200 >6EWX-A nrPDB Length = 484 Score = 32.7 bits (73), Expect = 0.48, Method: Compositional matrix adjust. Identities = 44/197 (22%), Positives = 71/197 (36%), Gaps = 48/197 (24%) Query: 279 GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL------------------- 319 P E R F ++ GLE L ++RDL EN+LL Sbjct: 203 AEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPT 262 Query: 320 ----------------------DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL 357 + IS+ A + P G + + +APE++ Sbjct: 263 TTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIV 322 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE--EVDRRVLETEEVYSHKFSEE 415 + +Y D + G LIYE++ +PF R + +R+ D L T +YS + Sbjct: 323 SASQYRKF-DEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQL 381 Query: 416 AKSICKMLLTKDAKQRL 432 A +LL D +R+ Sbjct: 382 A----HLLLEADPIKRI 394 >4WUA-A nrPDB Length = 401 Score = 32.0 bits (71), Expect = 0.79, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 62/147 (42%), Gaps = 19/147 (12%) Query: 188 QYRVLGKGGFGEVCACQVR--ATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV---- 241 +Y V+ K G+G + GK + ++ K AL+E ++L+ V Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKS---AEHYTETALDEIRLLKSVRNSD 98 Query: 242 ----NSQFVVNLAYAYETKDA----LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 N + VV L ++ +C+V ++ LK+ I G Sbjct: 99 PNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKW-IIKSNYQGLPLPCVKKIIQ 157 Query: 294 EILCGLEDLHRE-NTVYRDLKPENILL 319 ++L GL+ LH + ++ D+KPENILL Sbjct: 158 QVLQGLDYLHTKCRIIHTDIKPENILL 184 Score = 29.3 bits (64), Expect = 5.0, Method: Compositional matrix adjust. Identities = 17/61 (27%), Positives = 27/61 (44%), Gaps = 2/61 (3%) Query: 325 IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSP 384 ++I+DLG A + + + T Y + EVL Y D W C+ +E+ G Sbjct: 239 VKIADLGNACWVHKH--FTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYL 296 Query: 385 F 385 F Sbjct: 297 F 297 >4AZV-A nrPDB Length = 569 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 13/44 (29%), Positives = 24/44 (54%) Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE 338 +L L L ++ + D++P N+++D H R+ D G V P+ Sbjct: 348 LLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFGSIVTTPQ 391 >5M07-A nrPDB Length = 276 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 38/208 (18%), Positives = 69/208 (33%), Gaps = 17/208 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 VT + R+LG GEV Q A K L + E ++ + Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAAR 86 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + ++ + E L + + ++G D H+ + L + L+ Sbjct: 87 LFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALD 146 Query: 301 DLHRENTVYRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 H+ ++RD+ P N++L I ++D G+A + Y APE+ Sbjct: 147 YAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPEL 193 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSP 384 D + L + G P Sbjct: 194 SAGADVDGRADQYALALTAIHLFAGAPP 221 >2IHB-B nrPDB Length = 153 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 25/107 (23%), Positives = 49/107 (45%), Gaps = 3/107 (2%) Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120 P G FR+F + E + +L ++ ++ EK KEI +L+ K+ +Q Sbjct: 42 PEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKAS---SQ 98 Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFF 167 V + S+ EK+L++P +F + ++ + + +L S F Sbjct: 99 VNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLF 145 >6BHC-A nrPDB Length = 438 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 49/218 (22%), Positives = 83/218 (38%), Gaps = 39/218 (17%) Query: 255 TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKP 314 T++ CL + L H +P E + ++ GLE L + + DL+ Sbjct: 150 TREVPCLTVADFVRDSLAQH---GKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRL 206 Query: 315 ENILLDDY---------------------GHIRISDLGLAVK---IPEGDLIRGRVGTVG 350 EN+LL Y + +S+ A + + + +++R + Sbjct: 207 ENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQ----S 262 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE--EVDRRVLETEEVY 408 +APE++ +Y D + G LIYEM+ +PF E +RE D + Y Sbjct: 263 RLAPEIITATQYK-KCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSPY 321 Query: 409 SHKFSEEAKSI-----CKMLLTKDAKQRLGCQEEGAAE 441 S + A + + +L DAK L C G E Sbjct: 322 SRGLQQLASCLLNPNPSERILISDAKGILQCLLWGPRE 359 >6G4J-A nrPDB Length = 315 Score = 30.8 bits (68), Expect = 1.8, Method: Compositional matrix adjust. Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 3/51 (5%) Query: 294 EILCGLEDLHRENTVYRDLKPENILLDD-YGHIRISDLGLAVKIPEGDLIR 343 ++L L LH++ ++ DLKP+N+++ IR D+G K EG I+ Sbjct: 131 QLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTK--EGRAIK 179 >4AZW-A nrPDB Length = 471 Score = 30.8 bits (68), Expect = 1.8, Method: Compositional matrix adjust. Identities = 13/44 (29%), Positives = 24/44 (54%) Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE 338 +L L L ++ + D++P N+++D H R+ D G V P+ Sbjct: 348 LLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFGSIVTTPQ 391 >2I59-A nrPDB Length = 138 Score = 30.8 bits (68), Expect = 1.9, Method: Compositional matrix adjust. Identities = 25/107 (23%), Positives = 49/107 (45%), Gaps = 3/107 (2%) Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120 P G FR+F + E + +L ++ ++ EK KEI +L+ K+ +Q Sbjct: 22 PEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKAS---SQ 78 Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFF 167 V + S+ EK+L++P +F + ++ + + +L S F Sbjct: 79 VNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLF 125 >5VE6-A nrPDB Length = 492 Score = 28.9 bits (63), Expect = 5.8, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 21/43 (48%) Query: 277 NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL 319 + P E R F ++ GLE L ++RDL EN+LL Sbjct: 199 HQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >4V6W-AT nrPDB Length = 156 Score = 28.9 bits (63), Expect = 7.0, Method: Composition-based stats. Identities = 18/54 (33%), Positives = 29/54 (53%), Gaps = 8/54 (14%) Query: 477 VLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPN 530 V DI+Q + K V + F K TG + +P Q ++++T FKEL + P+ Sbjct: 6 VKDIDQHAVTKAVAV------FLKK--TGKLKVPDQMDIVKTAKFKELAPYDPD 51 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4TNB-A nrPDB 944 0.0 3NYO-A nrPDB 805 0.0 4YHJ-A nrPDB 769 0.0 3C51-A nrPDB 647 0.0 3PVW-A nrPDB 566 e-162 5UUU-A nrPDB 552 e-157 4L42-A nrPDB 364 e-101 2JDO-A nrPDB 363 e-100 3MV5-A nrPDB 357 7e-99 5KCV-A nrPDB 355 4e-98 4WB7-A nrPDB 354 7e-98 4RLP-A nrPDB 351 4e-97 5N23-A nrPDB 350 1e-96 1VZO-A nrPDB 348 6e-96 4RA4-A nrPDB 347 8e-96 5X3F-B nrPDB 347 1e-95 3A8W-A nrPDB 346 2e-95 3TXO-A nrPDB 345 3e-95 1FOT-A nrPDB 344 6e-95 5D9K-A nrPDB 343 1e-94 3PFQ-A nrPDB 342 3e-94 2I0E-A nrPDB 341 7e-94 3HDN-A nrPDB 339 2e-93 2Z7Q-A nrPDB 338 4e-93 5F9E-A nrPDB 336 1e-92 5FET-A nrPDB 331 6e-91 5JN2-A nrPDB 330 1e-90 5DYK-A nrPDB 328 4e-90 2JC6-A nrPDB 326 2e-89 3MA6-A nrPDB 325 2e-89 4FG9-A nrPDB 324 9e-89 4MVF-A nrPDB 323 1e-88 3HZT-A nrPDB 323 2e-88 3DXN-A nrPDB 323 2e-88 6BDL-A nrPDB 323 2e-88 3TKU-A nrPDB 318 3e-87 3LIJ-A nrPDB 316 2e-86 4OTD-A nrPDB 316 2e-86 3DFA-A nrPDB 316 2e-86 3NCG-A nrPDB 315 4e-86 4YZB-A nrPDB 314 7e-86 6ED6-A nrPDB 314 8e-86 6E9W-A nrPDB 313 2e-85 4RGJ-A nrPDB 312 3e-85 2VN9-A nrPDB 311 4e-85 4FR4-A nrPDB 311 7e-85 5FG8-A nrPDB 311 7e-85 2JAM-A nrPDB 310 8e-85 5IG1-A nrPDB 310 9e-85 4CRS-A nrPDB 310 1e-84 2VZ6-A nrPDB 310 1e-84 3KK8-A nrPDB 309 1e-84 2BDW-A nrPDB 309 1e-84 5U6Y-A nrPDB 309 2e-84 4AW2-A nrPDB 309 2e-84 4D28-A nrPDB 309 3e-84 3Q5I-A nrPDB 308 5e-84 5ES1-A nrPDB 308 6e-84 2J90-A nrPDB 307 1e-83 2V7O-A nrPDB 306 1e-83 3MN3-A nrPDB 306 2e-83 3H4J-B nrPDB 306 2e-83 3BHH-A nrPDB 305 3e-83 3ORZ-A nrPDB 305 4e-83 5LOH-A nrPDB 304 7e-83 3SOA-A nrPDB 303 2e-82 5KZ7-A nrPDB 301 4e-82 3D2K-A nrPDB 301 8e-82 4REW-A nrPDB 300 9e-82 2YAB-A nrPDB 300 1e-81 2QNJ-A nrPDB 300 1e-81 3TAC-A nrPDB 299 1e-81 3GUB-A nrPDB 299 2e-81 4RED-A nrPDB 299 2e-81 5YKS-A nrPDB 299 2e-81 2YCR-A nrPDB 299 2e-81 2VD5-A nrPDB 298 4e-81 5WAX-A nrPDB 298 5e-81 4CFH-A nrPDB 298 6e-81 4CFF-A nrPDB 297 9e-81 2A27-A nrPDB 297 1e-80 1ZWS-A nrPDB 297 1e-80 4CZT-A nrPDB 296 1e-80 4UZD-A nrPDB 296 2e-80 5EZV-A nrPDB 295 3e-80 2YZA-A nrPDB 295 4e-80 3I6U-A nrPDB 295 4e-80 2BPM-A nrPDB 294 5e-80 5XZW-A nrPDB 294 9e-80 4JXF-A nrPDB 293 1e-79 3UC3-A nrPDB 291 7e-79 2W4O-A nrPDB 290 9e-79 3F3Z-A nrPDB 290 1e-78 5JZN-A nrPDB 290 1e-78 1PHK-A nrPDB 289 2e-78 3COM-A nrPDB 289 2e-78 2Y7J-A nrPDB 289 3e-78 1KOB-A nrPDB 288 4e-78 3ZUT-A nrPDB 286 2e-77 4YNZ-A nrPDB 286 2e-77 4PDS-A nrPDB 286 2e-77 6BXI-A nrPDB 286 2e-77 2X4F-A nrPDB 285 3e-77 5J5T-A nrPDB 285 4e-77 4C0T-A nrPDB 284 8e-77 3UTO-A nrPDB 284 9e-77 4LG4-A nrPDB 283 1e-76 3UDB-A nrPDB 283 2e-76 2HAK-A nrPDB 282 2e-76 4CSV-A nrPDB 282 3e-76 3DB8-A nrPDB 282 3e-76 1KOA-A nrPDB 281 5e-76 6FDY-U nrPDB 281 8e-76 4B8L-A nrPDB 280 9e-76 4B6L-A nrPDB 280 1e-75 6FD3-A nrPDB 280 1e-75 6AO5-A nrPDB 279 2e-75 6C9D-A nrPDB 279 2e-75 2UV2-A nrPDB 277 9e-75 4NIF-A nrPDB 277 1e-74 4JG6-A nrPDB 277 1e-74 3NIZ-A nrPDB 276 2e-74 3IS5-A nrPDB 276 3e-74 4I6B-A nrPDB 275 3e-74 4CQG-A nrPDB 274 5e-74 6CMJ-A nrPDB 274 8e-74 4AF3-A nrPDB 274 9e-74 4AGU-A nrPDB 273 1e-73 4D2V-A nrPDB 273 1e-73 2F57-A nrPDB 272 2e-73 3Q53-A nrPDB 272 3e-73 3LM0-A nrPDB 272 4e-73 6GU6-A nrPDB 271 5e-73 4KS7-A nrPDB 271 5e-73 3FXW-A nrPDB 271 7e-73 2OU7-A nrPDB 270 1e-72 4J52-A nrPDB 270 1e-72 2Q0N-A nrPDB 270 2e-72 4QMW-A nrPDB 269 2e-72 4JDH-A nrPDB 269 2e-72 6HXF-B nrPDB 269 2e-72 4KRC-A nrPDB 269 3e-72 4XBR-A nrPDB 269 3e-72 1NY3-A nrPDB 269 3e-72 2OZA-A nrPDB 268 4e-72 3KA0-A nrPDB 268 5e-72 3DAK-A nrPDB 268 6e-72 4FIE-A nrPDB 268 6e-72 5D7A-A nrPDB 267 9e-72 2WQN-A nrPDB 267 9e-72 3KN6-A nrPDB 267 1e-71 5YV8-A nrPDB 267 1e-71 4BBM-A nrPDB 267 1e-71 4APC-A nrPDB 266 1e-71 5GRN-A nrPDB 266 2e-71 2XYN-A nrPDB 265 4e-71 1G3N-A nrPDB 264 6e-71 5DBX-A nrPDB 264 6e-71 1CM8-A nrPDB 264 8e-71 2XIK-A nrPDB 263 1e-70 4FZF-B nrPDB 263 2e-70 1V0B-A nrPDB 262 3e-70 3HKO-A nrPDB 261 5e-70 4WNO-A nrPDB 261 6e-70 4EWQ-A nrPDB 261 6e-70 4AU8-A nrPDB 261 1e-69 2HW6-A nrPDB 260 1e-69 5EFQ-A nrPDB 260 1e-69 3E7O-A nrPDB 259 2e-69 5AWM-A nrPDB 259 3e-69 4MYG-A nrPDB 259 3e-69 6NPU-A nrPDB 259 3e-69 6QAU-A nrPDB 257 7e-69 2XS0-A nrPDB 257 8e-69 6DTL-A nrPDB 257 1e-68 4XEY-B nrPDB 257 1e-68 1JNK-A nrPDB 256 3e-68 2F9G-A nrPDB 255 4e-68 2H8H-A nrPDB 254 6e-68 3FI2-A nrPDB 254 6e-68 4NST-A nrPDB 254 7e-68 6F3F-A nrPDB 254 1e-67 2FO0-A nrPDB 254 1e-67 3OHT-A nrPDB 254 1e-67 5SYS-A nrPDB 253 1e-67 4BGQ-A nrPDB 253 1e-67 3V5Q-A nrPDB 252 3e-67 4QNY-A nrPDB 252 3e-67 5H2U-A nrPDB 252 4e-67 3PPZ-A nrPDB 251 6e-67 6GQK-A nrPDB 251 6e-67 6CKI-A nrPDB 251 7e-67 6E2O-A nrPDB 250 1e-66 2DQ7-X nrPDB 250 2e-66 1TKI-A nrPDB 249 2e-66 5G6V-A nrPDB 249 2e-66 2PL0-A nrPDB 249 3e-66 5X02-A nrPDB 249 3e-66 3ZDU-A nrPDB 249 4e-66 3KRL-A nrPDB 248 4e-66 4AN9-A nrPDB 248 5e-66 4EBW-A nrPDB 247 7e-66 3GC9-A nrPDB 247 1e-65 3TT0-A nrPDB 247 1e-65 3BEA-A nrPDB 247 1e-65 4AT3-A nrPDB 246 2e-65 1U5R-A nrPDB 246 2e-65 1UA2-A nrPDB 246 2e-65 3G0E-A nrPDB 246 3e-65 2OGV-A nrPDB 245 3e-65 4XLV-A nrPDB 245 4e-65 2GCD-A nrPDB 245 5e-65 2W96-B nrPDB 245 5e-65 4R7H-A nrPDB 244 1e-64 5Z33-A nrPDB 244 1e-64 4U41-A nrPDB 243 1e-64 3A4O-X nrPDB 243 1e-64 6CCF-A nrPDB 243 1e-64 4IC8-A nrPDB 242 2e-64 4ZSG-A nrPDB 242 3e-64 2J0K-A nrPDB 242 3e-64 6CQF-A nrPDB 241 6e-64 3MIA-A nrPDB 241 6e-64 3OZ6-A nrPDB 241 9e-64 3GQL-A nrPDB 240 1e-63 4E93-A nrPDB 240 1e-63 2XNP-A nrPDB 240 1e-63 4QTB-A nrPDB 240 1e-63 4E7W-A nrPDB 240 2e-63 3GC0-A nrPDB 240 2e-63 3QUP-A nrPDB 239 2e-63 4XUF-A nrPDB 239 2e-63 5NGU-A nrPDB 239 3e-63 4GS6-A nrPDB 238 4e-63 5A46-A nrPDB 238 4e-63 6E4F-A nrPDB 238 5e-63 5AIR-A nrPDB 238 5e-63 4RC3-A nrPDB 238 6e-63 3BGP-A nrPDB 237 8e-63 1JPA-A nrPDB 237 1e-62 1K9A-A nrPDB 236 2e-62 2BRG-A nrPDB 236 2e-62 2HK5-A nrPDB 236 3e-62 1S9I-A nrPDB 236 3e-62 5TUR-A nrPDB 236 3e-62 3ALO-A nrPDB 235 4e-62 4H1J-A nrPDB 235 4e-62 5VO2-A nrPDB 235 4e-62 5KKR-C nrPDB 235 5e-62 3SXS-A nrPDB 235 5e-62 5KMM-A nrPDB 234 6e-62 6FEX-A nrPDB 234 6e-62 4XI2-A nrPDB 234 8e-62 1BYG-A nrPDB 234 9e-62 3M42-A nrPDB 234 9e-62 4UY9-A nrPDB 234 9e-62 1LUF-A nrPDB 234 1e-61 2PSQ-A nrPDB 234 1e-61 3EQC-A nrPDB 234 1e-61 3DKO-A nrPDB 234 1e-61 5X5O-A nrPDB 234 1e-61 3I81-A nrPDB 233 1e-61 4XCU-A nrPDB 233 1e-61 4UYA-A nrPDB 233 2e-61 4X7Q-B nrPDB 233 2e-61 4O2Z-A nrPDB 233 2e-61 4EQM-A nrPDB 233 2e-61 3VN9-A nrPDB 232 2e-61 3FME-A nrPDB 232 3e-61 3CJF-A nrPDB 232 3e-61 5AMN-A nrPDB 232 4e-61 5MJB-A nrPDB 232 4e-61 4P5Q-A nrPDB 231 5e-61 4Y93-A nrPDB 231 6e-61 2R2P-A nrPDB 231 7e-61 4K33-A nrPDB 230 1e-60 6BSD-A nrPDB 230 1e-60 3DTC-A nrPDB 230 1e-60 2Y6O-A nrPDB 230 1e-60 1FVR-A nrPDB 230 1e-60 3QGY-A nrPDB 229 3e-60 6DBM-A nrPDB 229 3e-60 1AD5-A nrPDB 229 3e-60 5Y86-A nrPDB 229 3e-60 3DLS-A nrPDB 229 4e-60 5L6P-A nrPDB 229 4e-60 5EG3-A nrPDB 228 5e-60 2WTK-C nrPDB 228 6e-60 4OLI-A nrPDB 227 8e-60 4HZS-A nrPDB 227 9e-60 1U54-B nrPDB 227 1e-59 2VWV-A nrPDB 227 1e-59 4E20-A nrPDB 226 2e-59 5B2L-A nrPDB 226 2e-59 1ZXE-A nrPDB 226 3e-59 5U6C-A nrPDB 225 3e-59 5FM2-A nrPDB 225 4e-59 3BBT-B nrPDB 225 5e-59 3ZBF-A nrPDB 225 6e-59 4M7I-A nrPDB 224 8e-59 2I6L-A nrPDB 224 9e-59 4PDO-A nrPDB 224 9e-59 5HI2-A nrPDB 224 1e-58 6FER-A nrPDB 224 1e-58 5VD3-A nrPDB 223 2e-58 5TQX-A nrPDB 223 2e-58 5UIU-A nrPDB 222 3e-58 4PWN-A nrPDB 222 3e-58 3KUL-B nrPDB 222 3e-58 5U6B-A nrPDB 222 4e-58 3OMV-A nrPDB 222 4e-58 3N9X-A nrPDB 220 1e-57 4KIK-B nrPDB 220 1e-57 3ORP-A nrPDB 220 1e-57 3NIE-A nrPDB 220 2e-57 3PG1-A nrPDB 219 2e-57 5HIE-A nrPDB 219 2e-57 5ZTN-A nrPDB 219 3e-57 2A1A-B nrPDB 218 4e-57 3E3P-A nrPDB 218 5e-57 2W1I-A nrPDB 218 5e-57 5HVK-A nrPDB 217 7e-57 3QA8-A nrPDB 217 8e-57 3LZB-A nrPDB 217 1e-56 3RP9-A nrPDB 216 2e-56 5GNK-A nrPDB 216 2e-56 4YFF-A nrPDB 216 2e-56 5HLW-A nrPDB 216 2e-56 6CTH-A nrPDB 215 3e-56 6J5U-C nrPDB 215 4e-56 3PP0-A nrPDB 215 6e-56 3UIU-A nrPDB 214 1e-55 5X8I-B nrPDB 214 1e-55 3IO7-A nrPDB 213 1e-55 6DBN-A nrPDB 212 3e-55 3C1X-A nrPDB 212 3e-55 1U59-A nrPDB 212 3e-55 4TPT-A nrPDB 212 3e-55 3PLS-A nrPDB 212 5e-55 5AP3-A nrPDB 212 5e-55 5TOS-A nrPDB 212 5e-55 6FYV-A nrPDB 211 5e-55 3AOX-A nrPDB 211 6e-55 4HVI-A nrPDB 211 7e-55 6GVJ-A nrPDB 210 1e-54 5O0Y-A nrPDB 210 2e-54 4Y83-A nrPDB 209 2e-54 3EB0-A nrPDB 209 2e-54 3HMP-A nrPDB 209 3e-54 6O6Q-A nrPDB 209 4e-54 4IDT-A nrPDB 208 4e-54 4LRM-A nrPDB 208 5e-54 2OZO-A nrPDB 208 6e-54 2WO6-A nrPDB 208 6e-54 4JLC-A nrPDB 207 8e-54 4OW8-A nrPDB 206 2e-53 4X3F-A nrPDB 206 2e-53 6B2Q-A nrPDB 206 2e-53 2ZMD-A nrPDB 205 3e-53 4EUU-A nrPDB 205 4e-53 4EUT-A nrPDB 205 4e-53 3UIM-A nrPDB 204 7e-53 4G3E-A nrPDB 204 1e-52 5LPZ-A nrPDB 204 1e-52 5LPV-A nrPDB 204 1e-52 4C59-A nrPDB 203 2e-52 6NT9-A nrPDB 203 2e-52 6O8B-A nrPDB 202 3e-52 4NEU-A nrPDB 201 6e-52 4FL3-A nrPDB 200 1e-51 4MD7-E nrPDB 200 1e-51 5C26-A nrPDB 200 1e-51 3ZZW-A nrPDB 200 1e-51 2RIO-A nrPDB 200 1e-51 3LLT-A nrPDB 199 3e-51 6HMD-A nrPDB 198 5e-51 5WNO-A nrPDB 198 5e-51 2PVN-A nrPDB 198 5e-51 6EII-A nrPDB 197 1e-50 5UNP-A nrPDB 194 7e-50 2QKW-B nrPDB 194 8e-50 5XVU-A nrPDB 193 2e-49 3RAW-A nrPDB 192 3e-49 2PMN-X nrPDB 192 4e-49 3LMG-A nrPDB 190 1e-48 5WNL-A nrPDB 190 2e-48 3QD2-B nrPDB 189 2e-48 4IAN-A nrPDB 189 3e-48 4LQP-A nrPDB 189 3e-48 6HV0-A nrPDB 189 4e-48 5XD6-A nrPDB 189 4e-48 4PL5-B nrPDB 189 5e-48 2BUJ-A nrPDB 188 8e-48 2H34-A nrPDB 187 1e-47 5TE0-A nrPDB 187 2e-47 5AR8-A nrPDB 186 2e-47 6BFN-A nrPDB 183 2e-46 5VC6-A nrPDB 183 2e-46 3Q4U-A nrPDB 182 3e-46 4CRL-A nrPDB 182 5e-46 5IKW-A nrPDB 181 8e-46 2JD5-A nrPDB 181 8e-46 5VDK-A nrPDB 179 4e-45 3SV0-A nrPDB 176 3e-44 2Y4I-B nrPDB 176 3e-44 3MDY-A nrPDB 174 7e-44 4M66-A nrPDB 174 9e-44 3MY0-A nrPDB 174 9e-44 4TN6-A nrPDB 174 1e-43 4LFI-A nrPDB 173 2e-43 1PY5-A nrPDB 172 4e-43 4F9B-A nrPDB 171 9e-43 5FQD-C nrPDB 170 1e-42 5CEK-A nrPDB 170 1e-42 6DC0-A nrPDB 170 1e-42 5L2Q-C nrPDB 169 3e-42 5E8V-A nrPDB 165 5e-41 2CMW-A nrPDB 165 6e-41 4BTK-A nrPDB 165 6e-41 4NFN-A nrPDB 165 6e-41 2CHL-A nrPDB 164 1e-40 4RT7-A nrPDB 163 2e-40 2C47-A nrPDB 163 2e-40 3SOC-A nrPDB 162 6e-40 3HNG-A nrPDB 160 1e-39 5X18-A nrPDB 160 2e-39 3VHK-A nrPDB 159 4e-39 3G2F-A nrPDB 158 6e-39 4XHH-A nrPDB 155 6e-38 4NT4-A nrPDB 154 1e-37 4XHL-A nrPDB 153 2e-37 2PZI-A nrPDB 151 9e-37 4Y12-A nrPDB 151 1e-36 2QLU-A nrPDB 150 2e-36 5OAT-A nrPDB 132 5e-31 4L68-A nrPDB 128 6e-30 6EQI-C nrPDB 120 2e-27 5DMZ-A nrPDB 100 4e-21 Sequences not found previously or not previously below threshold: 5O2B-A nrPDB 220 1e-57 5O2C-A nrPDB 220 1e-57 4F0G-A nrPDB 197 2e-50 2WTK-B nrPDB 167 2e-41 4WUA-A nrPDB 166 3e-41 2X7G-A nrPDB 166 3e-41 1CSN-A nrPDB 145 7e-35 5X1R-A nrPDB 141 8e-34 4M69-B nrPDB 137 1e-32 4BTF-A nrPDB 137 1e-32 5M07-A nrPDB 136 2e-32 5USZ-A nrPDB 135 4e-32 5J0A-A nrPDB 135 4e-32 4MWI-A nrPDB 135 4e-32 3REP-A nrPDB 133 3e-31 4L00-A nrPDB 131 1e-30 4I94-A nrPDB 128 9e-30 5C01-A nrPDB 118 8e-27 4WOV-A nrPDB 118 8e-27 6J6I-B nrPDB 116 3e-26 4JRN-A nrPDB 112 4e-25 5UV4-A nrPDB 111 9e-25 5CLR-A nrPDB 98 8e-21 5UU1-A nrPDB 93 3e-19 4O1O-A nrPDB 93 4e-19 2RSV-A nrPDB 89 5e-18 2LAV-A nrPDB 89 5e-18 4IX6-A nrPDB 85 9e-17 6EAS-A nrPDB 84 1e-16 4OAU-C nrPDB 79 5e-15 6EWX-A nrPDB 76 4e-14 6G4J-A nrPDB 74 1e-13 6BHC-A nrPDB 72 1e-12 4CI6-B nrPDB 71 1e-12 2JII-A nrPDB 70 4e-12 6M7Z-A nrPDB 68 1e-11 5GZ9-A nrPDB 64 1e-10 5GZA-A nrPDB 63 4e-10 6G38-A nrPDB 62 8e-10 4CYJ-A nrPDB 58 7e-09 4AZW-A nrPDB 57 2e-08 4AZV-A nrPDB 56 4e-08 5VE6-A nrPDB 55 6e-08 3ENH-A nrPDB 53 4e-07 4WWA-A nrPDB 53 4e-07 3BYV-A nrPDB 49 6e-06 2W1Z-A nrPDB 48 8e-06 4CZY-B nrPDB 48 1e-05 4BWP-A nrPDB 48 2e-05 1TQM-A nrPDB 46 6e-05 3DZO-A nrPDB 45 9e-05 2I59-A nrPDB 45 9e-05 2IHB-B nrPDB 45 1e-04 3Q60-A nrPDB 44 2e-04 2JNU-A nrPDB 38 0.008 2BV1-A nrPDB 38 0.008 4BVU-A nrPDB 38 0.015 6FAI-l nrPDB 38 0.016 6FDN-A nrPDB 36 0.032 6G18-v nrPDB 36 0.033 5YK0-A nrPDB 35 0.071 1DK8-A nrPDB 33 0.39 >4TNB-A nrPDB Length = 590 Score = 944 bits (2441), Expect = 0.0, Method: Composition-based stats. Identities = 587/590 (99%), Positives = 588/590 (99%) Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ Sbjct: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60 Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGK+IMTKYLTPKSPVFIAQ Sbjct: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKKIMTKYLTPKSPVFIAQ 120 Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP Sbjct: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180 Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 DLH ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC Sbjct: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480 KMLLTKDAKQRLGCQEE AAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI Sbjct: 421 KMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480 Query: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN 540 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN Sbjct: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN 540 Query: 541 HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS 590 HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS Sbjct: 541 HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS 590 >3NYO-A nrPDB Length = 576 Score = 805 bits (2079), Expect = 0.0, Method: Composition-based stats. Identities = 403/558 (72%), Positives = 470/558 (84%), Gaps = 1/558 (0%) Query: 2 ELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQP 61 ELENIVANTVLLKAREGGGG RKGKSKKW+++L+FPHISQCE+LR +++RDY SLC++QP Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQP 61 Query: 62 IGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQV 121 IGRLLFR+FC TRP L + FLD VAEYEVTPD+K G+++ +L+ P I +V Sbjct: 62 IGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEV 121 Query: 122 GQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPV 181 + LV+ ++L Q PCK+LF + HEYL PF +YLDS++F+RFLQWKWLERQPV Sbjct: 122 PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPV 181 Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK+LEKKRIKKRKGE+MALNEKQILEKV Sbjct: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 NS+FVV+LAYAYETKDALCLVLT+MNGGDLKFHIY+MG GF E RA+FYAAEI CGLED Sbjct: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 LHRE VYRDLKPENILLDD+GHIRISDLGLAV +PEG I+GRVGTVGYMAPEV+ N+R Sbjct: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 Y SPD+W LGCL+YEMI GQSPF+ RK+K+KREEV+R V E E YS +FS +A+S+C Sbjct: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIE 481 LL KD +RLGC+ A EVK HP F+ +NFKRL AGML+PPF PDP+A+YCKDVLDIE Sbjct: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE 481 Query: 482 QFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLN-RN 540 QFSTVKGV L+ TD DFY KF+TGSV IPWQNEM+ETECF+ELNVFG +G++PPDL+ + Sbjct: 482 QFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKG 541 Query: 541 HPPEPPKKGLLQRLFKRQ 558 PP PPKKGLLQRLF RQ Sbjct: 542 QPPAPPKKGLLQRLFSRQ 559 >4YHJ-A nrPDB Length = 584 Score = 769 bits (1986), Expect = 0.0, Method: Composition-based stats. Identities = 381/560 (68%), Positives = 458/560 (81%), Gaps = 3/560 (0%) Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60 MELENIVAN++LLKAR+GG GK+ G+SKKWKEIL P +SQC +LR +I++DY SLCDKQ Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60 Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120 PIGR LFRQFC+T+P L+ +I+FLD+VAEYEV DE + G I+ ++ K + + Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120 Query: 121 VGQDLVSQTEEKLLQK-PCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179 + D+V++ L ++ P K+ F C + H YLRGEPF EY +S +F +FLQWKWLERQ Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180 Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACK+L+KKRIKKRKGE+MALNEK+ILE Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 KV S+FVV+LAYAYETKDALCLVLTIMNGGDLKFHIYN+GNPGF+E+RA+FYAAE+ CGL Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 EDL RE VYRDLKPENILLDD GHIRISDLGLA +IPEG +RGRVGTVGYMAPEV+NN Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 ++Y SPD+WGLGCLIYEMI+G SPF+ KEKVK EEVD+R+ E YS KFSE+AKSI Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479 C+MLLTK+ +RLGC+ EGAA VK+HP F+++NF+RLEA ML+PPF PDP AVYCKDVLD Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480 Query: 480 IEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNR 539 IEQFS VKG+ LD D+DFY++F+TG VSIPWQNEMIE+ CFK++N LP DL++ Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540 Query: 540 N--HPPEPPKKGLLQRLFKR 557 N P P +G RLF+R Sbjct: 541 NIHTPVSRPNRGFFYRLFRR 560 >3C51-A nrPDB Length = 543 Score = 647 bits (1668), Expect = 0.0, Method: Composition-based stats. Identities = 254/536 (47%), Positives = 361/536 (67%), Gaps = 11/536 (2%) Query: 3 LENIVANTVLLKAREGGGGKRKG---KSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDK 59 LE +VAN+ + AR G G + +K+ LK P +S+CE LR ++D + +C + Sbjct: 6 LETVVANSAFIAAR-GSFDASSGPASRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLE 64 Query: 60 QPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIA 119 QPIG+ LF+QF T +Q + +Y+ D +K + + YL P++ +F + Sbjct: 65 QPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCS 124 Query: 120 QVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179 + + V++ LF ++V +L PF E+LDS++F RFLQWKWLE Q Sbjct: 125 FLDAETVARARAG----AGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQ 180 Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P+ ++ F +RVLG+GGFGEV ACQ++ATGK+YACK+L KKR+KKRKG A+ EK+IL Sbjct: 181 PMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILA 240 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALFYAAEILC 297 KV+S+F+V+LAYA+ETK LCLV+TIMNGGD+++HIYN+ NPGF+E RA+FY A+I+ Sbjct: 241 KVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS 300 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-IRGRVGTVGYMAPEV 356 GLE LH+ N +YRDLKPEN+LLDD G++RISDLGLAV++ G +G GT G+MAPE+ Sbjct: 301 GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL 360 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 L + Y S DY+ LG +YEMI + PFR R EKV+ +E+ +RVLE Y KFS + Sbjct: 361 LLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPAS 420 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKD 476 K C+ LL KD ++RLG ++ ++ HP FR++++++LEAGML PPFVPD R VY K+ Sbjct: 421 KDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKN 480 Query: 477 VLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGT 532 + D+ FSTVKGV + D +F+ +F++G+ IPWQ EMIET F +LNV+ P+G Sbjct: 481 IQDVGAFSTVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDGV 536 >3PVW-A nrPDB Length = 695 Score = 566 bits (1460), Expect = e-162, Method: Composition-based stats. Identities = 198/537 (36%), Positives = 291/537 (54%), Gaps = 20/537 (3%) Query: 2 ELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSL--CDK 59 +LE ++A+ L A E ++ K K +L P I + DR + Sbjct: 3 DLEAVLADVSYLMAMEKSKATPAARASK-KILLPEPSIRSVMQ-KYLEDRGEVTFEKIFS 60 Query: 60 QPIGRLLFRQFCETR-PGLECYIQFLDSVAEYE-VTPDEKLGEKGKEIMTKYLTPKSPVF 117 Q +G LLFR FC + ++F + + +YE + +E+ +EI Y+ + Sbjct: 61 QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC 120 Query: 118 IAQVGQDLVSQTEEKLLQKPCK-ELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWL 176 + + + L++K +LF + + + LRG+ F ++++S F RF QWK + Sbjct: 121 SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180 Query: 177 ERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE++ALNE+ Sbjct: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 Query: 236 QILEKV---NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 +L V + F+V ++YA+ T D L +L +MNGGDL +H+ G F E FYA Sbjct: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYA 298 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYM 352 AEI+ GLE +H VYRDLKP NILLD++GH+RISDLGLA + VGT GYM Sbjct: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHGYM 357 Query: 353 APEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 APEVL Y S D++ LGC++++++ G SPFR K K K E+DR L Sbjct: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDS 416 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRA 471 FS E +S+ + LL +D +RLGC GA EVK PFFR+++++ + PP +P Sbjct: 417 FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGE 476 Query: 472 VYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNV 526 V D DI F KG+ L +D + Y F ++S WQ E+ ET F +N Sbjct: 477 VNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTINA 531 >5UUU-A nrPDB Length = 547 Score = 552 bits (1423), Expect = e-157, Method: Composition-based stats. Identities = 197/530 (37%), Positives = 284/530 (53%), Gaps = 20/530 (3%) Query: 9 NTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSL--CDKQPIGRLL 66 N A E GG ++ K K +L P I + DR + Q +G LL Sbjct: 19 NLYFQGAMEPGGSTPAARASK-KILLPEPSIRSVMQ-KYLEDRGEVTFEKIFSQKLGYLL 76 Query: 67 FRQFCETR-PGLECYIQFLDSVAEYE-VTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQD 124 FR FC ++F + + +YE + +E+ + +EI Y+ + + Sbjct: 77 FRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKS 136 Query: 125 LVSQTEEKLLQKPCK-ELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ-PVT 182 + L +K +LF + + + LRG+ F ++++S F RF QWK +E +T Sbjct: 137 ATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLT 196 Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV- 241 N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE++ALNE+ +L V Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 242 --NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + F+V ++YA+ T D L +L +MNGGDL +H+ G F E FYAAEI+ GL Sbjct: 257 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIILGL 314 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN- 358 E +H VYRDLKP NILLD++GH+RISDLGLA + VGT GYMAPEVL Sbjct: 315 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHGYMAPEVLQK 373 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 Y S D++ LGC++++++ G SPFR K K K E+DR L FS E +S Sbjct: 374 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRS 432 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVL 478 + + LL +D +RLGC GA EVK PFFR+++++ + PP +P V D Sbjct: 433 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 492 Query: 479 DIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNV 526 DI F KG+ L +D + Y F ++S WQ E+ ET F +N Sbjct: 493 DIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTINA 540 >4L42-A nrPDB Length = 346 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 117/325 (36%), Positives = 182/325 (56%), Gaps = 18/325 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVR---ATGKMYACKRLEKKRI-KKRKGESMALNEKQILE 239 F RVLGKGG+G+V + TGK++A K L+K I + K + E+ ILE Sbjct: 18 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 77 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +V F+V+L YA++T L L+L ++GG+L + G F E+ A FY AEI L Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEISMAL 135 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358 LH++ +YRDLKPENI+L+ GH++++D GL + I +G + GT+ YMAPE+L Sbjct: 136 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + + D+W LG L+Y+M+ G PF G R++ ++L+ + ++EA+ Sbjct: 196 RSGHNRAVDWWSLGALMYDMLTGAPPFTGEN----RKKTIDKILKCKLNLPPYLTQEARD 251 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVL 478 + K LL ++A RLG A EV+ HPFFR++N++ L A ++PPF P + Sbjct: 252 LLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP-----LLQSEE 306 Query: 479 DIEQFST--VKGVNLDHTDDDFYSK 501 D+ QF + + +D DD S+ Sbjct: 307 DVSQFDSKFTRQTPVDSPDDSTLSE 331 >2JDO-A nrPDB Length = 342 Score = 363 bits (931), Expect = e-100, Method: Composition-based stats. Identities = 128/348 (36%), Positives = 184/348 (52%), Gaps = 13/348 (3%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 VT N F ++LGKG FG+V + +ATG+ YA K L K+ I + + + E ++L+ Sbjct: 7 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 66 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 F+ L YA++T D LC V+ NGG+L FH+ F EERA FY AEI+ LE Sbjct: 67 TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVSALE 124 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNN 359 LH + VYRD+K EN++LD GHI+I+D GL + I +G ++ GT Y+APEVL + Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 184 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 YG + D+WGLG ++YEM+ G+ PF + E + +L E + S EAKS+ Sbjct: 185 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQD----HERLFELILMEEIRFPRTLSPEAKSL 240 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479 LL KD KQRLG A EV H FF ++N++ + L PPF P + D Sbjct: 241 LAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD 300 Query: 480 IEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVF 527 E T + + + D Y + + EM E F + + Sbjct: 301 DE--FTAQSITITPPDR--YDSLGLLELDQREEQEMFED--FDYIADW 342 >3MV5-A nrPDB Length = 342 Score = 357 bits (917), Expect = 7e-99, Method: Composition-based stats. Identities = 123/320 (38%), Positives = 180/320 (56%), Gaps = 10/320 (3%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + + L E ++L+ Sbjct: 6 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 65 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 F+ L Y+++T D LC V+ NGG+L FH+ F E+RA FY AEI+ L Sbjct: 66 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSAL 123 Query: 300 EDLHR-ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVL 357 + LH +N VYRDLK EN++LD GHI+I+D GL + I +G ++ GT Y+APEVL Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 + YG + D+WGLG ++YEM+ G+ PF + E++ +L E + EAK Sbjct: 184 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIRFPRTLGPEAK 239 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDV 477 S+ LL KD KQRLG E A E+ +H FF + ++ + L PPF P + Sbjct: 240 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 299 Query: 478 LDIEQFSTVKGVNLDHTDDD 497 D E+F T + + + D D Sbjct: 300 FD-EEF-TAQMITITPPDQD 317 >5KCV-A nrPDB Length = 460 Score = 355 bits (910), Expect = 4e-98, Method: Composition-based stats. Identities = 120/323 (37%), Positives = 176/323 (54%), Gaps = 8/323 (2%) Query: 161 YLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK 220 D+ + + VT N F ++LGKG FG+V + +ATG+ YA K L+K+ Sbjct: 139 PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE 198 Query: 221 RIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN 280 I + + L E ++L+ F+ L Y+++T D LC V+ NGG+L FH+ Sbjct: 199 VIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--E 256 Query: 281 PGFEEERALFYAAEILCGLEDLHR-ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPE 338 F E+RA FY AEI+ L+ LH +N VYRDLK EN++LD GHI+I+D GL + I + Sbjct: 257 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD 316 Query: 339 GDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD 398 G ++ GT Y+APEVL + YG + D+WGLG ++YEM+ G+ PF + E++ Sbjct: 317 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD----HEKLF 372 Query: 399 RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEA 458 +L E + EAKS+ LL KD KQRLG E A E+ +H FF + ++ + Sbjct: 373 ELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 432 Query: 459 GMLDPPFVPDPRAVYCKDVLDIE 481 L PPF P + D E Sbjct: 433 KKLSPPFKPQVTSETDTRYFDEE 455 >4WB7-A nrPDB Length = 405 Score = 354 bits (908), Expect = 7e-98, Method: Composition-based stats. Identities = 108/400 (27%), Positives = 195/400 (48%), Gaps = 10/400 (2%) Query: 88 AEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQ 147 +Y T G +EI Y ++ + ++ ++ + K + + L + Sbjct: 2 KDYYQTLGLARGASDEEIKRAY-RRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKR 60 Query: 148 SVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRA 207 + + GE E+L D +W+ + + F + + LG G FG V + + Sbjct: 61 EIFDR-YGEEVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKE 119 Query: 208 TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMN 267 TG YA K L+K+++ K K LNEK+IL+ VN F+V L ++++ L +V+ + Sbjct: 120 TGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVP 179 Query: 268 GGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRI 327 GG++ H+ +G F E A FYAA+I+ E LH + +YRDLKPEN+L+D G+I++ Sbjct: 180 GGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 237 Query: 328 SDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 +D G A ++ GT Y+APE++ ++ Y + D+W LG LIYEM G PF Sbjct: 238 TDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA 295 Query: 388 RKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 + ++ +++ + + FS + K + + LL D +R G + G ++K H + Sbjct: 296 DQPI----QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 351 Query: 448 FRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVK 487 F ++ + ++ PF+P + D + ++ Sbjct: 352 FATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIR 391 >4RLP-A nrPDB Length = 288 Score = 351 bits (901), Expect = 4e-97, Method: Composition-based stats. Identities = 110/289 (38%), Positives = 169/289 (58%), Gaps = 11/289 (3%) Query: 184 NTFRQYRVLGKGGFGEVCACQVR---ATGKMYACKRLEKKRI-KKRKGESMALNEKQILE 239 F RVLGKGG+G+V + TGK++A K L+K I + K + E+ ILE Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +V F+V+L YA++T L L+L ++GG+L + G F E+ A FY AEI L Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEISMAL 122 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358 LH++ +YRDLKPENI+L+ GH++++D GL + I +G + GT+ YMAPE+L Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + + D+W LG L+Y+M+ G PF G R++ ++L+ + ++EA+ Sbjct: 183 RSGHNRAVDWWSLGALMYDMLTGAPPFTGEN----RKKTIDKILKCKLNLPPYLTQEARD 238 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 + K LL ++A RLG A EV+ HPFFR++N++ L A ++PPF P Sbjct: 239 LLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >5N23-A nrPDB Length = 352 Score = 350 bits (897), Expect = 1e-96, Method: Composition-based stats. Identities = 101/333 (30%), Positives = 171/333 (51%), Gaps = 7/333 (2%) Query: 155 GEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYAC 214 E E+L D +W+ + + F + R LG G FG V + + TG YA Sbjct: 13 QESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAM 72 Query: 215 KRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH 274 K L+K+++ K K LNEK+I + VN F+V L ++++ L +VL GG++ H Sbjct: 73 KILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSH 132 Query: 275 IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV 334 + +G F E A FYAA+I+ E LH + +YRDLKPEN+L+D G+I+++D G A Sbjct: 133 LRRIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAK 190 Query: 335 KIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKR 394 ++ +G GT Y+APE++ ++ Y + D+W LG LIYEM G PF + Sbjct: 191 RV-KGRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI--- 246 Query: 395 EEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK 454 ++ +++ + + FS + K + + LL D +R G + G ++K H +F ++ Sbjct: 247 -QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI 305 Query: 455 RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVK 487 + ++ PF+P + D + ++ Sbjct: 306 AIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIR 338 >1VZO-A nrPDB Length = 355 Score = 348 bits (892), Expect = 6e-96, Method: Composition-based stats. Identities = 117/314 (37%), Positives = 171/314 (54%), Gaps = 16/314 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQV---RATGKMYACKRLEKKRI-KKRKGESMALNE 234 + V F +VLG G +G+V + TGK+YA K L+K I +K K E Sbjct: 49 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 108 Query: 235 KQILEKVN-SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 +Q+LE + S F+V L YA++T+ L L+L +NGG+L H+ F E Y Sbjct: 109 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER--FTEHEVQIYVG 166 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI--PEGDLIRGRVGTVGY 351 EI+ LE LH+ +YRD+K ENILLD GH+ ++D GL+ + E + GT+ Y Sbjct: 167 EIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEY 226 Query: 352 MAPEVLNN--QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS 409 MAP+++ + + D+W LG L+YE++ G SPF EK + E+ RR+L++E Y Sbjct: 227 MAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP 286 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDP 469 + S AK + + LL KD K+RLGC A E+K H FF+ +N+ L A + PF P Sbjct: 287 QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVI 346 Query: 470 RAVYCKDVLDIEQF 483 R D LD+ F Sbjct: 347 R-----DELDVSNF 355 >4RA4-A nrPDB Length = 355 Score = 347 bits (890), Expect = 8e-96, Method: Composition-based stats. Identities = 124/340 (36%), Positives = 183/340 (53%), Gaps = 13/340 (3%) Query: 164 SMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIK 223 S DR L+R +T F VLGKG FG+V + T ++YA K L+K + Sbjct: 2 SPSEDRKQPSNNLDRVKLT--DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVI 59 Query: 224 KRKGESMALNEKQILEKVNSQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 + + EK++L ++ F+ L ++T D L V+ +NGGDL +HI +G Sbjct: 60 QDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK-- 117 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDL 341 F+E +A+FYAAEI GL LH+ +YRDLK +N++LD GHI+I+D G+ + + +G Sbjct: 118 FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT 177 Query: 342 IRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV 401 R GT Y+APE++ Q YG S D+W G L+YEM+ GQ PF G E E+ + + Sbjct: 178 TRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDED----ELFQSI 233 Query: 402 LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGML 461 +E Y S+EA SICK L+TK +RLGC EG +V+ H FFR +++++LE + Sbjct: 234 MEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREI 293 Query: 462 DPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSK 501 PPF P ++ F T L D + Sbjct: 294 QPPFKPKVSGKGAENFDK---FFTRGQPVLTPPDQLVIAN 330 >5X3F-B nrPDB Length = 393 Score = 347 bits (890), Expect = 1e-95, Method: Composition-based stats. Identities = 96/330 (29%), Positives = 169/330 (51%), Gaps = 8/330 (2%) Query: 158 FHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRL 217 +L D +W+ + + F + + LG G FG V + + +G YA K L Sbjct: 58 VQAFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKIL 117 Query: 218 EKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYN 277 +K+++ K K LNEK+IL+ VN F+V L ++++ L +V+ + GG++ H+ Sbjct: 118 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRR 177 Query: 278 MGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP 337 +G F E A FYAA+I+ E LH + +YRDLKPEN+L+D G+I+++D G A ++ Sbjct: 178 IGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK 235 Query: 338 EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEV 397 GT Y+APE++ ++ Y + D+W LG LIYEM G PF + ++ Sbjct: 236 --GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI----QI 289 Query: 398 DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLE 457 +++ + + FS + K + + LL D +R G + G ++K H +F ++ + Sbjct: 290 YEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIY 349 Query: 458 AGMLDPPFVPDPRAVYCKDVLDIEQFSTVK 487 ++ PF+P + D + ++ Sbjct: 350 QRKVEAPFIPKFKGPGDTSNFDDYEEEEIR 379 >3A8W-A nrPDB Length = 345 Score = 346 bits (887), Expect = 2e-95, Method: Composition-based stats. Identities = 114/330 (34%), Positives = 178/330 (53%), Gaps = 12/330 (3%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P+ F RV+G+G + +V +++ T ++YA K ++K+ + + EK + E Sbjct: 5 PLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE 64 Query: 240 KV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + N F+V L ++T+ L V+ +NGGDL FH+ EE A FY+AEI Sbjct: 65 QASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRK--LPEEHARFYSAEISLA 122 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVL 357 L LH +YRDLK +N+LLD GHI+++D G+ + + GD GT Y+APE+L Sbjct: 123 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 182 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPF-----RGRKEKVKREEVDRRVLETEEVYSHKF 412 + YG S D+W LG L++EM+ G+SPF ++ + + + +LE + Sbjct: 183 RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSL 242 Query: 413 SEEAKSICKMLLTKDAKQRLGCQEEG-AAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRA 471 S +A S+ K L KD K+RLGC + A+++ HPFFRN+++ +E + PPF P+ Sbjct: 243 SVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISG 302 Query: 472 VYCKDVLDIEQFSTVKGVNLDHTDDDFYSK 501 + D D QF T + V L DDD K Sbjct: 303 EFGLDNFD-SQF-TNEPVQLTPDDDDIVRK 330 >3TXO-A nrPDB Length = 353 Score = 345 bits (885), Expect = 3e-95, Method: Composition-based stats. Identities = 115/328 (35%), Positives = 168/328 (51%), Gaps = 15/328 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-N 242 + F RVLGKG FG+V +V+ TG +YA K L+K I + + EK+IL N Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 F+ L ++T D L V+ +NGGDL FHI F+E RA FYAAEI+ L L Sbjct: 83 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR--FDEARARFYAAEIISALMFL 140 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQR 361 H + +YRDLK +N+LLD GH +++D G+ + I G GT Y+APE+L Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 200 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 YG + D+W +G L+YEM+ G +PF E E +L E VY E+A I K Sbjct: 201 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFE----AILNDEVVYPTWLHEDATGILK 256 Query: 422 MLLTKDAKQRLGCQEEGAAE-VKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480 +TK+ RLG +G + RHPFF+ +++ +L ++PPF P ++ D Sbjct: 257 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP 316 Query: 481 ------EQFSTVKGVNLDHTDDDFYSKF 502 + + +L + D + F Sbjct: 317 DFIKEEPVLTPIDEGHLPMINQDEFRNF 344 >1FOT-A nrPDB Length = 318 Score = 344 bits (883), Expect = 6e-95, Method: Composition-based stats. Identities = 100/320 (31%), Positives = 163/320 (50%), Gaps = 10/320 (3%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F+ R LG G FG V + R G+ YA K L+K+ + + K +E+ +L V Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 F++ + ++ + +++ + GG+L + + F A FYAAE+ LE LH Sbjct: 67 FIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRK--SQRFPNPVAKFYAAEVCLALEYLHS 124 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 ++ +YRDLKPENILLD GHI+I+D G A +P D+ GT Y+APEV++ + Y Sbjct: 125 KDIIYRDLKPENILLDKNGHIKITDFGFAKYVP--DVTYTLCGTPDYIAPEVVSTKPYNK 182 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLL 424 S D+W G LIYEM+ G +PF + ++L E + F+E+ K + L+ Sbjct: 183 SIDWWSFGILIYEMLAGYTPFYDSNTM----KTYEKILNAELRFPPFFNEDVKDLLSRLI 238 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDV--LDIEQ 482 T+D QRLG + G +VK HP+F+ + +++L + ++ P+ P + + Sbjct: 239 TRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPE 298 Query: 483 FSTVKGVNLDHTDDDFYSKF 502 GV + D + F Sbjct: 299 EDINYGVQGEDPYADLFRDF 318 >5D9K-A nrPDB Length = 330 Score = 343 bits (880), Expect = 1e-94, Method: Composition-based stats. Identities = 109/301 (36%), Positives = 161/301 (53%), Gaps = 11/301 (3%) Query: 185 TFRQYRVLGKGGFGEVCACQVR---ATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 F +VLG+G FG+V + ++YA K L+K +K R + E+ IL +V Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM-ERDILVEV 89 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 N F+V L YA++T+ L L+L + GGDL + F EE FY AE+ L+ Sbjct: 90 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALALDH 147 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQ 360 LH +YRDLKPENILLD+ GHI+++D GL+ + I GTV YMAPEV+N + Sbjct: 148 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRR 207 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 + S D+W G L++EM+ G PF+G+ R+E +L+ + S EA+S+ Sbjct: 208 GHTQSADWWSFGVLMFEMLTGTLPFQGKD----RKETMTMILKAKLGMPQFLSPEAQSLL 263 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480 +ML ++ RLG +G E+KRH FF +++ +L + PPF P D Sbjct: 264 RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 323 Query: 481 E 481 E Sbjct: 324 E 324 >3PFQ-A nrPDB Length = 674 Score = 342 bits (877), Expect = 3e-94, Method: Composition-based stats. Identities = 118/337 (35%), Positives = 180/337 (53%), Gaps = 13/337 (3%) Query: 167 FDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRK 226 +F +R +T F VLGKG FG+V + + T ++YA K L+K + + Sbjct: 326 ISKFDNNGNRDRMKLT--DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDD 383 Query: 227 GESMALNEKQILEKVNSQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEE 285 + EK++L F+ L ++T D L V+ +NGGDL +HI +G F+E Sbjct: 384 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKE 441 Query: 286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRG 344 A+FYAAEI GL L + +YRDLK +N++LD GHI+I+D G+ + I +G + Sbjct: 442 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKT 501 Query: 345 RVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 GT Y+APE++ Q YG S D+W G L+YEM+ GQ+PF G E E+ + ++E Sbjct: 502 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED----ELFQSIMEH 557 Query: 405 EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPP 464 Y S+EA +ICK L+TK +RLGC EG ++K H FFR +++++LE + PP Sbjct: 558 NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 617 Query: 465 FVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSK 501 + P ++ +F T L D + Sbjct: 618 YKPKASGRNAENFD---RFFTRHPPVLTPPDQEVIRN 651 >2I0E-A nrPDB Length = 353 Score = 341 bits (874), Expect = 7e-94, Method: Composition-based stats. Identities = 115/319 (36%), Positives = 174/319 (54%), Gaps = 11/319 (3%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F VLGKG FG+V + + T ++YA K L+K + + + EK++L Sbjct: 21 DFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKP 80 Query: 245 -FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 F+ L ++T D L V+ +NGGDL +HI +G F+E A+FYAAEI GL L Sbjct: 81 PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQ 138 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRY 362 + +YRDLK +N++LD GHI+I+D G+ + I +G + GT Y+APE++ Q Y Sbjct: 139 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 198 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKM 422 G S D+W G L+YEM+ GQ+PF G E E+ + ++E Y S+EA +ICK Sbjct: 199 GKSVDWWAFGVLLYEMLAGQAPFEGEDED----ELFQSIMEHNVAYPKSMSKEAVAICKG 254 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQ 482 L+TK +RLGC EG ++K H FFR +++++LE + PP+ P ++ + Sbjct: 255 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFD---R 311 Query: 483 FSTVKGVNLDHTDDDFYSK 501 F T L D + Sbjct: 312 FFTRHPPVLTPPDQEVIRN 330 >3HDN-A nrPDB Length = 373 Score = 339 bits (870), Expect = 2e-93, Method: Composition-based stats. Identities = 113/299 (37%), Positives = 158/299 (52%), Gaps = 9/299 (3%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL-EKVNS 243 F +V+GKG FG+V + +A YA K L+KK I K+K E ++E+ +L + V Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 98 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 F+V L ++++T D L VL +NGG+L +H+ F E RA FYAAEI L LH Sbjct: 99 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERC--FLEPRARFYAAEIASALGYLH 156 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRY 362 N VYRDLKPENILLD GHI ++D GL + I GT Y+APEVL+ Q Y Sbjct: 157 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY 216 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKM 422 + D+W LG ++YEM+ G PF R E+ +L + A+ + + Sbjct: 217 DRTVDWWCLGAVLYEMLYGLPPFYSRNT----AEMYDNILNKPLQLKPNITNSARHLLEG 272 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIE 481 LL KD +RLG ++ E+K H FF +N+ L + PPF P+ D E Sbjct: 273 LLQKDRTKRLGAKD-DFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 330 >2Z7Q-A nrPDB Length = 321 Score = 338 bits (868), Expect = 4e-93, Method: Composition-based stats. Identities = 111/298 (37%), Positives = 161/298 (54%), Gaps = 11/298 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVR---ATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 F +VLG+G FG+V + +G +YA K L+K +K R + E+ IL VN Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-ERDILADVN 88 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 FVV L YA++T+ L L+L + GGDL + F EE FY AE+ GL+ L Sbjct: 89 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALGLDHL 146 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQR 361 H +YRDLKPENILLD+ GHI+++D GL+ + I GTV YMAPEV+N Q Sbjct: 147 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 206 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 + S D+W G L++EM+ G PF+G+ R+E +L+ + S EA+S+ + Sbjct: 207 HSHSADWWSYGVLMFEMLTGSLPFQGKD----RKETMTLILKAKLGMPQFLSTEAQSLLR 262 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479 L ++ RLG +GA E+KRH F+ +++ +L + PPF P D Sbjct: 263 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 320 >5F9E-A nrPDB Length = 353 Score = 336 bits (863), Expect = 1e-92, Method: Composition-based stats. Identities = 111/328 (33%), Positives = 175/328 (53%), Gaps = 18/328 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-N 242 F +++LGKG FG+V + + T + +A K L+K + + EK++L Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 F+ ++ ++TK+ L V+ +NGGDL +HI + F+ RA FYAAEI+ GL+ L Sbjct: 79 HPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK--FDLSRATFYAAEIILGLQFL 136 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG-RVGTVGYMAPEVLNNQR 361 H + VYRDLK +NILLD GHI+I+D G+ + GD GT Y+APE+L Q+ Sbjct: 137 HSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQK 196 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 Y S D+W G L+YEM+ GQSPF G+ E EE+ + Y +EAK + Sbjct: 197 YNHSVDWWSFGVLLYEMLIGQSPFHGQDE----EELFHSIRMDNPFYPRWLEKEAKDLLV 252 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIE 481 L ++ ++RLG + ++++HP FR +N++ LE +DPPF P ++ + D E Sbjct: 253 KLFVREPEKRLGVR----GDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKE 308 Query: 482 QFSTVKGVNLDH------TDDDFYSKFS 503 + ++ D + + FS Sbjct: 309 FLNEKPRLSFADRALINSMDQNMFRNFS 336 >5FET-A nrPDB Length = 847 Score = 331 bits (848), Expect = 6e-91, Method: Composition-based stats. Identities = 99/316 (31%), Positives = 159/316 (50%), Gaps = 9/316 (2%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 ++ V + R++G+G FG V + T YA K + K+ I ++ E+ Sbjct: 525 MQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLER 584 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 +I + + F++ L ++ + + ++ GG+L I +G + +A FY I Sbjct: 585 EITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLG--LLSKPQAQFYLGSI 642 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 + +E LH N VYRDLKPENILLD G++++ D G A KI VGT YMAPE Sbjct: 643 ILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQ--GRAYTLVGTPHYMAPE 700 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE- 414 V+ + YG + D W LG +YE I G PF +E E+ R +L + + S+ Sbjct: 701 VILGKGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQL--EIFRDILTGQLTFPDYVSDQ 758 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYC 474 ++ ++ K LL + + R+GC G ++K H FF N N+ +L +L+PP V Y Sbjct: 759 DSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGET-YA 817 Query: 475 KDVLDIEQFSTVKGVN 490 +D+ DI+Q +N Sbjct: 818 EDI-DIKQIEEEDALN 832 >5JN2-A nrPDB Length = 525 Score = 330 bits (846), Expect = 1e-90, Method: Composition-based stats. Identities = 82/279 (29%), Positives = 141/279 (50%), Gaps = 11/279 (3%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + + ++ RVLGKG FGEV C+ + TG+ A K + K+++K++ + L E Q+L++ Sbjct: 64 IFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQ 123 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 ++ ++ L +E K LV + GG+L I + F E A ++L G+ Sbjct: 124 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR--FSEVDAARIIRQVLSGIT 181 Query: 301 DLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL 357 +H+ V+RDLKPEN+LL+ +IRI D GL+ ++ ++GT Y+APEVL Sbjct: 182 YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL 241 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 + Y D W G ++Y ++ G PF G E ++V++ E K SE AK Sbjct: 242 HGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAK 300 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRL 456 + + +LT R+ A + H + + +++ Sbjct: 301 DLIRKMLTYVPSMRIS-----ARDALDHEWIQTYTKEQI 334 >5DYK-A nrPDB Length = 853 Score = 328 bits (841), Expect = 4e-90, Method: Composition-based stats. Identities = 98/309 (31%), Positives = 157/309 (50%), Gaps = 9/309 (2%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 ++ V + R++G+G FG V + T YA K + K+ I ++ E+ Sbjct: 531 MQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLER 590 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 +I + + F++ L ++ + ++ GG+L I +G + +A FY I Sbjct: 591 EITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLG--LLSKSQAQFYLGSI 648 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 + +E LH N VYRDLKPENILLD G++++ D G A K+ VGT YMAPE Sbjct: 649 ILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQ--GRAYTLVGTPHYMAPE 706 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE- 414 V+ + YG + D W LG +YE I G PF +E E+ R +L + + ++ Sbjct: 707 VILGKGYGCTVDIWALGICLYEFICGPLPFGNDEEDQL--EIFRDILTGQLTFPDYVTDT 764 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYC 474 ++ ++ K LL + + R+GC G ++K HPFF N N+ +L +LDPP V Y Sbjct: 765 DSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSET-YA 823 Query: 475 KDVLDIEQF 483 +D+ DI+Q Sbjct: 824 EDI-DIKQI 831 >2JC6-A nrPDB Length = 334 Score = 326 bits (835), Expect = 2e-89, Method: Composition-based stats. Identities = 91/278 (32%), Positives = 141/278 (50%), Gaps = 12/278 (4%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN 233 W ++ K F LG G F EV + +ATGK++A K + KK +K + ES N Sbjct: 12 SWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK--ESSIEN 69 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 E +L K+ + +V L YE+ + L LV+ +++GG+L I G + E+ A Sbjct: 70 EIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIR 127 Query: 294 EILCGLEDLHRENTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRGRVGTVG 350 ++L + LHR V+RDLKPEN+L D+ I ISD GL+ +GD++ GT G Sbjct: 128 QVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPG 187 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 Y+APEVL + Y + D W +G + Y ++ G PF + E++ + E + Y Sbjct: 188 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWD 247 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 S+ AK + L+ KD +R C + RHP+ Sbjct: 248 DISDSAKDFIRNLMEKDPNKRYTC-----EQAARHPWI 280 >3MA6-A nrPDB Length = 298 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 85/293 (29%), Positives = 146/293 (49%), Gaps = 18/293 (6%) Query: 163 DSMFFD---RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEK 219 ++++F F+Q + + ++ RVLGKG FGEV C+ + TG+ A K + K Sbjct: 12 ENLYFQGPGMFVQHS----TAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISK 67 Query: 220 KRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG 279 +++K++ + L E Q+L++++ ++ L +E K LV + GG+L I + Sbjct: 68 RQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK 127 Query: 280 NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKI 336 F E A ++L G+ +H+ V+RDLKPEN+LL+ +IRI D GL+ Sbjct: 128 R--FSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF 185 Query: 337 PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE 396 ++ ++GT Y+APEVL+ Y D W G ++Y ++ G PF G E ++ Sbjct: 186 EASKKMKDKIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKK 244 Query: 397 VDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 V++ E K SE AK + + +LT R+ A + H + + Sbjct: 245 VEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRIS-----ARDALDHEWIQ 292 >4FG9-A nrPDB Length = 320 Score = 324 bits (830), Expect = 9e-89, Method: Composition-based stats. Identities = 84/280 (30%), Positives = 138/280 (49%), Gaps = 15/280 (5%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231 +WK E ++ + VLG G F EV + + T K+ A K + K+ ++ ++G Sbjct: 9 RWKQAED---IRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEG--SM 63 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 NE +L K+ +V L YE+ L L++ +++GG+L I G + E A Sbjct: 64 ENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKG--FYTERDASRL 121 Query: 292 AAEILCGLEDLHRENTVYRDLKPENIL---LDDYGHIRISDLGLAVKIPEGDLIRGRVGT 348 ++L ++ LH V+RDLKPEN+L LD+ I ISD GL+ G ++ GT Sbjct: 122 IFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGT 181 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY 408 GY+APEVL + Y + D W +G + Y ++ G PF + E++ + E + Y Sbjct: 182 PGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPY 241 Query: 409 SHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 S+ AK + L+ KD ++R C + +HP+ Sbjct: 242 WDDISDSAKDFIRHLMEKDPEKRFTC-----EQALQHPWI 276 >4MVF-A nrPDB Length = 506 Score = 323 bits (829), Expect = 1e-88, Method: Composition-based stats. Identities = 74/273 (27%), Positives = 126/273 (46%), Gaps = 14/273 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 ++ + LG+G +G V + T ++YA K +K R+K E +I++K++ Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN---RFFQEIEIMKKLD 112 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +V L YE + + L++ + +G +L I G F E+ A +I + L Sbjct: 113 HPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENG--SFTEKNAATIMKQIFSAIFYL 170 Query: 303 HRENTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 H N V+RDLKPEN L + ++I D GL+ + G+ + GT Y+AP+VL+ Sbjct: 171 HSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG 230 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 + Y D W G ++Y ++ G PF G + ++V + E S +AK++ Sbjct: 231 K-YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNL 289 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 LLT + +R E HP+ M Sbjct: 290 ITKLLTYNPNERCTI-----EEALNHPWITQMT 317 >3HZT-A nrPDB Length = 467 Score = 323 bits (828), Expect = 2e-88, Method: Composition-based stats. Identities = 79/268 (29%), Positives = 137/268 (51%), Gaps = 11/268 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + +++ + LG G +GEV C+ + TG A K ++K + L+E +L++++ Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L +E K LV+ + GG+L I + F E A ++L G LH Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI--ILRQKFSEVDAAVIMKQVLSGTTYLH 121 Query: 304 RENTVYRDLKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 + N V+RDLKPEN+LL+ I+I D GL+ G ++ R+GT Y+APEVL + Sbjct: 122 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR-K 180 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 +Y D W G ++Y ++ G PF G+ ++ + V++ + + S+EAK + Sbjct: 181 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 240 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 K++LT + +R+ A E HP+ Sbjct: 241 KLMLTYEPSKRIS-----AEEALNHPWI 263 >3DXN-A nrPDB Length = 287 Score = 323 bits (827), Expect = 2e-88, Method: Composition-based stats. Identities = 80/289 (27%), Positives = 142/289 (49%), Gaps = 23/289 (7%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F + +++ + LG G +GEV C+ + TG A K ++K + Sbjct: 12 ENLYFQGL------------SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSV 59 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 L+E +L++++ ++ L +E K LV+ + GG+L I + Sbjct: 60 TTTSNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI--ILRQK 117 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH---IRISDLGLAVKIPEG 339 F E A ++L G LH+ N V+RDLKPEN+LL+ I+I D GL+ G Sbjct: 118 FSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG 177 Query: 340 DLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 ++ R+GT Y+APEVL ++Y D W G ++Y ++ G PF G+ ++ + V++ Sbjct: 178 GKMKERLGTAYYIAPEVLR-KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK 236 Query: 400 RVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + + S+EAK + K++LT + +R+ A E HP+ Sbjct: 237 GKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRIS-----AEEALNHPWI 280 >6BDL-A nrPDB Length = 347 Score = 323 bits (827), Expect = 2e-88, Method: Composition-based stats. Identities = 94/314 (29%), Positives = 154/314 (49%), Gaps = 9/314 (2%) Query: 185 TFRQYRVLGKGGFGEVCACQVR-ATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 F LG GGFG V Q++ K +A K L+K+ I + + +EKQI++ +S Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS 94 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 F+V L ++ L +++ GG+L + + G FE+ FY A ++ LH Sbjct: 95 DFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRG--SFEDSTTRFYTACVVEAFAYLH 152 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 + +YRDLKPEN++LD G+ ++ D G A KI G GT Y+APE++ N+ + Sbjct: 153 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 212 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 +S DYW LG L+YE++ G PF G + R + E + K ++ A ++ K L Sbjct: 213 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE--FPKKIAKNAANLIKKL 270 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF 483 + +RLG + G ++++H +F N++ L G L PP +P + D Sbjct: 271 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE 330 Query: 484 STVKGVNLDHTDDD 497 + DD+ Sbjct: 331 DNDEP----PPDDN 340 >3TKU-A nrPDB Length = 433 Score = 318 bits (816), Expect = 3e-87, Method: Composition-based stats. Identities = 99/367 (26%), Positives = 183/367 (49%), Gaps = 36/367 (9%) Query: 145 CAQSVHEYLRGEPFHEYLDSMFFDRFLQW-----KWLERQPVTKNTFRQYRVLGKGGFGE 199 + H LR + + FL+W + ++ + + F +V+G+G FGE Sbjct: 54 YTECSHSALRRDK--------YVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGE 105 Query: 200 VCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDAL 259 V +++ T ++YA K L K + KR + E+ +L + Q++ L YA++ ++ L Sbjct: 106 VAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHL 165 Query: 260 CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL 319 LV+ GGDL + + E+ A FY E++ ++ +H+ + V+RD+KP+N+LL Sbjct: 166 YLVMDYYVGGDLLTLLSKFEDK-LPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLL 224 Query: 320 DDYGHIRISDLGLAVKIPEGDLIRGR--VGTVGYMAPEVLNNQ-----RYGLSPDYWGLG 372 D GHIR++D G +K+ + ++ VGT Y++PE+L +YG D+W LG Sbjct: 225 DVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLG 284 Query: 373 CLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH-----KFSEEAKSICKMLLTKD 427 +YEM+ G++PF E +++ EE + SEEAK + + L+ Sbjct: 285 VCMYEMLYGETPFYAES----LVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLIC-S 339 Query: 428 AKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVK 487 ++RLG + G + K+H FF +N++ + L+ P++PD + D++ ++ Sbjct: 340 RERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSDTSNFDVDD-DVLR 394 Query: 488 GVNLDHT 494 + Sbjct: 395 NTEILPP 401 >3LIJ-A nrPDB Length = 494 Score = 316 bits (810), Expect = 2e-86, Method: Composition-based stats. Identities = 84/310 (27%), Positives = 149/310 (48%), Gaps = 17/310 (5%) Query: 163 DSMFFDRFLQWK----WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE 218 ++++F LQ ++ +++ + LG G +GEV C+ + T A K + Sbjct: 12 ENLYFQGDLQATPGMFITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIR 71 Query: 219 KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM 278 K + S L E +L+ ++ ++ L +E K LV+ GG+L I + Sbjct: 72 KTSV-STSSNSKLLEEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEI--I 128 Query: 279 GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVK 335 F E A ++L G+ LH+ N V+RDLKPEN+LL+ I+I D GL+ Sbjct: 129 HRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAV 188 Query: 336 IPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE 395 ++ R+GT Y+APEVL ++Y D W +G +++ ++ G PF G+ ++ Sbjct: 189 FENQKKMKERLGTAYYIAPEVLR-KKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILR 247 Query: 396 EVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR 455 +V++ + SE AK + K +L D+++R+ A + HP+ + M K+ Sbjct: 248 KVEKGKYTFDSPEWKNVSEGAKDLIKQMLQFDSQRRIS-----AQQALEHPWIKEMCSKK 302 Query: 456 LEAGMLDPPF 465 E+G+ P Sbjct: 303 -ESGIELPSL 311 >4OTD-A nrPDB Length = 341 Score = 316 bits (809), Expect = 2e-86, Method: Composition-based stats. Identities = 123/325 (37%), Positives = 179/325 (55%), Gaps = 13/325 (4%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK Sbjct: 4 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 63 Query: 236 QILEKV---NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 +IL V F+VNL ++T + +C V+ GGDL HI++ F E RA+FY+ Sbjct: 64 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD---VFSEPRAIFYS 120 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGY 351 A ++ GL+ LH VYRDLK +N+LLD G+++I+D GL + + GD GT + Sbjct: 121 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 180 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 +APEVL + Y + D+WGLG L+YEM+ G+SPF G E EEV ++ E Y Sbjct: 181 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 236 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRA 471 S EA I + LL ++ ++RLG E A +VK+ PFFR + ++ L A L PPFVP Sbjct: 237 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSG 296 Query: 472 VYCKDVLDIEQFSTVKGVNLDHTDD 496 D E+F+ L D Sbjct: 297 RTDVSNFD-EEFTGEAPT-LSPPRD 319 >3DFA-A nrPDB Length = 286 Score = 316 bits (809), Expect = 2e-86, Method: Composition-based stats. Identities = 80/274 (29%), Positives = 129/274 (47%), Gaps = 12/274 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + +LGKG FGEV C+ R T + YA K + K K K S L E ++L+K++ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKN-KDTSTILREVELLKKLDH 80 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L E + +V + GG+L I F E A ++ G+ +H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR--FSEHDAARIIKQVFSGITYMH 138 Query: 304 RENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 + N V+RDLKPENILL+ I+I D GL+ + ++ R+GT Y+APEVL Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT 198 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W G ++Y ++ G PF G+ E + V+ + S++AK + Sbjct: 199 -YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLI 257 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK 454 + +LT R+ A + HP+ + + + Sbjct: 258 RKMLTFHPSLRIT-----ATQCLEHPWIQKYSSE 286 >3NCG-A nrPDB Length = 486 Score = 315 bits (807), Expect = 4e-86, Method: Composition-based stats. Identities = 80/274 (29%), Positives = 129/274 (47%), Gaps = 12/274 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + +LGKG FGEV C+ R T + YA K + K K K S L E ++L+K++ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKN-KDTSTILREVELLKKLDH 80 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L E + +V + GG+L I F E A ++ G+ +H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR--FSEHDAARIIKQVFSGITYMH 138 Query: 304 RENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 + N V+RDLKPENILL+ I+I D GL+ + ++ R+GT Y+APEVL Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT 198 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W G ++Y ++ G PF G+ E + V+ + S++AK + Sbjct: 199 -YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLI 257 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK 454 + +LT R+ A + HP+ + + + Sbjct: 258 RKMLTFHPSLRIT-----ATQCLEHPWIQKYSSE 286 >4YZB-A nrPDB Length = 491 Score = 314 bits (805), Expect = 7e-86, Method: Composition-based stats. Identities = 81/272 (29%), Positives = 140/272 (51%), Gaps = 11/272 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + ++ RVLGKG FGEV C+ + TG+ YA K + K+++K++ + + L E ++L+K++ Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L +E K LV + GG+L I + F E A ++L G+ +H Sbjct: 90 PNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKR--FSEVDAARIIRQVLSGITYMH 147 Query: 304 RENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 + V+RDLKPEN+LL++ +IRI D GL+ ++ ++GT Y+APEVL+ Sbjct: 148 KNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGT 207 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W G ++Y ++ G PF G E ++V++ + K SE AK + Sbjct: 208 -YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLI 266 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 + +L R+ A + H + + + Sbjct: 267 RKMLAYVPTMRIS-----ARDALEHEWLKTTD 293 >6ED6-A nrPDB Length = 415 Score = 314 bits (804), Expect = 8e-86, Method: Composition-based stats. Identities = 104/333 (31%), Positives = 163/333 (48%), Gaps = 28/333 (8%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + +V+G+G FGEV + +A+ K+YA K L K + KR + E+ I+ NS Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +VV L YA++ L +V+ M GGDL M N E+ A FY AE++ L+ +H Sbjct: 148 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL---MSNYDVPEKWAKFYTAEVVLALDAIH 204 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR--GRVGTVGYMAPEVLNNQR 361 ++RD+KP+N+LLD +GH++++D G +K+ E ++ VGT Y++PEVL +Q Sbjct: 205 SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG 264 Query: 362 ----YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 YG D+W +G +YEM+ G +PF ++ + S+ AK Sbjct: 265 GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAK 324 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDV 477 ++ LT D + RLG G E+++HPFF+N + P VP Sbjct: 325 NLICAFLT-DREVRLG--RNGVEEIRQHPFFKNDQWHWDNIRETAAPVVP---------- 371 Query: 478 LDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIP 510 E S + N D +DD K + IP Sbjct: 372 ---ELSSDIDSSNFDDIEDD---KGDVETFPIP 398 >6E9W-A nrPDB Length = 443 Score = 313 bits (801), Expect = 2e-85, Method: Composition-based stats. Identities = 105/333 (31%), Positives = 163/333 (48%), Gaps = 28/333 (8%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + +V+G+G FGEV + ++T K+YA K L K + KR + E+ I+ NS Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +VV L YA++ L +V+ M GGDL M N E+ A FY AE++ L+ +H Sbjct: 162 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL---MSNYDVPEKWARFYTAEVVLALDAIH 218 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR--GRVGTVGYMAPEVLNNQR 361 ++RD+KP+N+LLD GH++++D G +K+ + ++R VGT Y++PEVL +Q Sbjct: 219 SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG 278 Query: 362 ----YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 YG D+W +G +YEM+ G +PF ++ + S+EAK Sbjct: 279 GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAK 338 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDV 477 ++ LT D + RLG G E+KRH FF+N + P VPD Sbjct: 339 NLICAFLT-DREVRLG--RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS------- 388 Query: 478 LDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIP 510 S + N D ++D K + IP Sbjct: 389 ------SDIDTSNFDDLEED---KGEEETFPIP 412 >4RGJ-A nrPDB Length = 520 Score = 312 bits (799), Expect = 3e-85, Method: Composition-based stats. Identities = 81/279 (29%), Positives = 136/279 (48%), Gaps = 12/279 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V ++ ++LGKG FGEV + + TG YA K + KK +K++ + L E ++L+ Sbjct: 57 VFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKM 116 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 ++ ++ L +E + LV + GG+L I + F E A +IL G+ Sbjct: 117 LDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKR--FYEIDAARIIKQILSGIT 174 Query: 301 DLHRENTVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 +H+ N V+RDLKPENILL + I+I D GL+ ++ ++GT Y+AP+V Sbjct: 175 YMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDV 234 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 L+ Y D W G ++Y ++ G PF G E ++V+ + K S++A Sbjct: 235 LHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKA 293 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR 455 K + K +L + R+ A + H + + M K Sbjct: 294 KDLIKKMLMYTSAVRIS-----ARDALEHEWIKMMTSKD 327 >2VN9-A nrPDB Length = 301 Score = 311 bits (798), Expect = 4e-85, Method: Composition-based stats. Identities = 71/269 (26%), Positives = 123/269 (45%), Gaps = 12/269 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + ++ + LGKG F V C TG+ YA K + K++ R + + E +I + Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE-REARICRLLKH 62 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + + LV ++ GG+L I + + E A +IL + H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILESVNHCH 120 Query: 304 RENTVYRDLKPENILLDDYGH---IRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNN 359 V+RDLKPEN+LL ++++D GLA+++ + G GT GY++PEVL Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 YG D W G ++Y ++ G PF + +++ + + EAK + Sbjct: 181 DPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 240 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 +LT + +R+ A+E +HP+ Sbjct: 241 INKMLTINPAKRIT-----ASEALKHPWI 264 >4FR4-A nrPDB Length = 384 Score = 311 bits (796), Expect = 7e-85, Method: Composition-based stats. Identities = 93/310 (30%), Positives = 166/310 (53%), Gaps = 10/310 (3%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 E + V + F R +GKG FG+VC Q T KMYA K + K++ +R E Q Sbjct: 8 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQ 67 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ + F+VNL Y+++ ++ + +V+ ++ GGDL++H+ N F+EE + E++ Sbjct: 68 IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFKEETVKLFICELV 125 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 L+ L + ++RD+KP+NILLD++GH+ I+D +A +P I GT YMAPE+ Sbjct: 126 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 185 Query: 357 LNNQR---YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 ++++ Y + D+W LG YE++ G+ P+ + +E+ T Y +S Sbjct: 186 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYH-IRSSTSSKEIVHTFETTVVTYPSAWS 244 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVY 473 +E S+ K LL + QR ++V+ P+ ++N+ + L P F+P+ + Sbjct: 245 QEMVSLLKKLLEPNPDQRFSQL----SDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLN 300 Query: 474 CKDVLDIEQF 483 C ++E+ Sbjct: 301 CDPTFELEEM 310 >5FG8-A nrPDB Length = 285 Score = 311 bits (796), Expect = 7e-85, Method: Composition-based stats. Identities = 73/269 (27%), Positives = 129/269 (47%), Gaps = 12/269 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + + LGKG F V C ++TG +A K + K++ R + + E +I K++ Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLE-REARICRKLHH 72 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + + ++ LV ++ GG+L I + + E A +IL + H Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESVNHCH 130 Query: 304 RENTVYRDLKPENILLDDYGH---IRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNN 359 + V+RDLKPEN+LL ++++D GLA+++ + G GT GY++PEVL Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKK 190 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 + YG S D W G ++Y ++ G PF + ++ + + EAK++ Sbjct: 191 EPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNL 250 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 +LT + +R+ AAE +HP+ Sbjct: 251 INQMLTVNPNKRIT-----AAEALKHPWI 274 >2JAM-A nrPDB Length = 304 Score = 310 bits (795), Expect = 8e-85, Method: Composition-based stats. Identities = 84/271 (30%), Positives = 132/271 (48%), Gaps = 14/271 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + TF VLG G F EV + R TGK++A K ++K +S NE +L+K+ Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKS---PAFRDSSLENEIAVLKKIK 64 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 + +V L YE+ LV+ +++GG+L I G + E+ A ++L ++ L Sbjct: 65 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYL 122 Query: 303 HRENTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 H V+RDLKPEN+L ++ I I+D GL+ + + ++ GT GY+APEVL Sbjct: 123 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQ 181 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 + Y + D W +G + Y ++ G PF E E++ E E + SE AK Sbjct: 182 KPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDF 241 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 LL KD +R C++ HP+ Sbjct: 242 ICHLLEKDPNERYTCEK-----ALSHPWIDG 267 >5IG1-A nrPDB Length = 344 Score = 310 bits (795), Expect = 9e-85, Method: Composition-based stats. Identities = 72/265 (27%), Positives = 124/265 (46%), Gaps = 11/265 (4%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 + V+GKG F V C + TG++ A K + K ++ + E I + + + Sbjct: 20 DKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINK-IKREIGICSSLQHEHI 78 Query: 247 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 V++ A+ + LV ++GG+L I + E+ A +IL L+ H +N Sbjct: 79 VSMRRAFRDESHFYLVFEYVSGGELFDEIVT--RKFYNEKDASACMHQILSALQHCHSKN 136 Query: 307 TVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 ++RDLKPEN+LL D ++I+D GLAV + +G G GT GY++PEV+ Y Sbjct: 137 IIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPYD 196 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 + D W G ++Y ++ G PF + ++ + + AK + K + Sbjct: 197 TAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAM 256 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFF 448 L + K+R Q E+ +HP+ Sbjct: 257 LEPNPKRRPTVQ-----ELLQHPWI 276 >4CRS-A nrPDB Length = 341 Score = 310 bits (794), Expect = 1e-84, Method: Composition-based stats. Identities = 125/337 (37%), Positives = 178/337 (52%), Gaps = 18/337 (5%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 +R FR VL +G FG+V + + T +M+A K L+K I R + EK+ Sbjct: 5 QRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKR 64 Query: 237 ILEKVN---SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 I E VN F+VNL ++TK+ +C V+ GGDL HI+ F E RA+FYAA Sbjct: 65 IFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD---VFSEPRAVFYAA 121 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYM 352 ++ GL+ LH VYRDLK +N+LLD G ++I+D GL + + GD GT ++ Sbjct: 122 CVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFL 181 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 APEVL Y + D+WGLG LIYEM+ G+SPF G E EEV ++ E Y Sbjct: 182 APEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRFL 237 Query: 413 SEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAV 472 S EA SI + LL ++ ++RLG E+ A +VK+HPFFR +++ L + PPF+P R Sbjct: 238 STEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGR 297 Query: 473 YCKDVLDIEQFSTV-------KGVNLDHTDDDFYSKF 502 D E S + L + + + F Sbjct: 298 EDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDF 334 >2VZ6-A nrPDB Length = 313 Score = 310 bits (794), Expect = 1e-84, Method: Composition-based stats. Identities = 72/292 (24%), Positives = 128/292 (43%), Gaps = 27/292 (9%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F ++ + LGKG F V C G+ YA K + K++ Sbjct: 16 ENLYFQSM---------------YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL 60 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 R + + E +I + +V L + + L+ ++ GG+L I + Sbjct: 61 SARDHQKLE-REARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREY 117 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH---IRISDLGLAVKIP-E 338 + E A +IL + H+ V+RDLKPEN+LL ++++D GLA+++ E Sbjct: 118 YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGE 177 Query: 339 GDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD 398 G GT GY++PEVL YG D W G ++Y ++ G PF + +++ Sbjct: 178 QQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIK 237 Query: 399 RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + + EAK + +LT + +R+ AAE +HP+ + Sbjct: 238 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRIT-----AAEALKHPWISH 284 >3KK8-A nrPDB Length = 284 Score = 309 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 69/268 (25%), Positives = 122/268 (45%), Gaps = 11/268 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + + LGKG F V C + TG +A K + K++ R + + E +I K+ Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE-REARICRKLQH 64 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + + + LV ++ GG+L I + + E A +IL + H Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESIAYCH 122 Query: 304 RENTVYRDLKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 V+R+LKPEN+LL ++++D GLA+++ + + G GT GY++PEVL Sbjct: 123 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKD 182 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W G ++Y ++ G PF + ++ + + EAKS+ Sbjct: 183 PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLI 242 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 +LT + K+R+ A + + P+ Sbjct: 243 DSMLTVNPKKRIT-----ADQALKVPWI 265 >2BDW-A nrPDB Length = 362 Score = 309 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 69/268 (25%), Positives = 122/268 (45%), Gaps = 11/268 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + + LGKG F V C + TG +A K + K++ R + + E +I K+ Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE-REARICRKLQH 87 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + + + LV ++ GG+L I + + E A +IL + H Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESIAYCH 145 Query: 304 RENTVYRDLKPENILLDDYGH---IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 V+R+LKPEN+LL ++++D GLA+++ + + G GT GY++PEVL Sbjct: 146 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKD 205 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W G ++Y ++ G PF + ++ + + EAKS+ Sbjct: 206 PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLI 265 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 +LT + K+R+ A + + P+ Sbjct: 266 DSMLTVNPKKRIT-----ADQALKVPWI 288 >5U6Y-A nrPDB Length = 461 Score = 309 bits (792), Expect = 2e-84, Method: Composition-based stats. Identities = 71/269 (26%), Positives = 123/269 (45%), Gaps = 12/269 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 ++ + LGKG F V C G+ YA K + K++ R + + E +I + Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE-REARICRLLKHPN 60 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 +V L + + L+ ++ GG+L I + + E A +IL + H+ Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 306 NTVYRDLKPENILLDDYGH---IRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQR 361 V+RDLKPEN+LL ++++D GLA+++ E G GT GY++PEVL Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 YG D W G ++Y ++ G PF + +++ + + EAK + Sbjct: 179 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 238 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 +LT + +R+ AAE +HP+ + Sbjct: 239 KMLTINPSKRIT-----AAEALKHPWISH 262 >4AW2-A nrPDB Length = 437 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 94/330 (28%), Positives = 171/330 (51%), Gaps = 27/330 (8%) Query: 169 RFLQW-----KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIK 223 +L+W +++ + + F +V+G+G FGEV +++ K++A K L K + Sbjct: 54 EYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEML 113 Query: 224 KRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF 283 KR + E+ +L +S+++ L YA++ + L LV+ GGDL + + Sbjct: 114 KRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDR-L 172 Query: 284 EEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR 343 EE A FY AE++ ++ +H+ + V+RD+KP+NIL+D GHIR++D G +K+ E ++ Sbjct: 173 PEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQ 232 Query: 344 GR--VGTVGYMAPEVLN-----NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE 396 VGT Y++PE+L RYG D+W LG +YEM+ G++PF E Sbjct: 233 SSVAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAES----LVE 288 Query: 397 VDRRVLETEEVYSH-----KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 +++ +E + SE AK + + L+ + RLG + G + K+HPFF + Sbjct: 289 TYGKIMNHKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLG--QNGIEDFKKHPFFSGI 345 Query: 452 NFKRLEAGMLDPPFVPDPRAVYCKDVLDIE 481 ++ + + P++P+ + D++ Sbjct: 346 DWDNI--RNCEAPYIPEVSSPTDTSNFDVD 373 >4D28-A nrPDB Length = 446 Score = 309 bits (791), Expect = 3e-84, Method: Composition-based stats. Identities = 83/301 (27%), Positives = 143/301 (47%), Gaps = 14/301 (4%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 + ++ + R +G+G F +V + TG A K + K I K + E Sbjct: 1 MTKKMRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREI 60 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 I++ V +V L +K + +VL + GG+L I + G +E+ + Y ++ Sbjct: 61 SIMKIVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGR--LKEDESRKYFQQL 118 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRVGTVGYMAP 354 + + H + +RDLKPEN+LLD G++++SD GL+ EG +L+ GT Y+AP Sbjct: 119 VDAVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAP 178 Query: 355 EVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 EVL+ Q Y G + D W G +++ ++ G PF + + R++ E FS Sbjct: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPF----SETDLPGLYRKINAAEFDCPPWFS 234 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVY 473 E K + +L + K R+ Q +K+ P+FR N+ + A + + D RAV+ Sbjct: 235 AEVKFLIHRILDPNPKTRIQIQG-----IKKDPWFRK-NYVPIRAREEEEVNLDDIRAVF 288 Query: 474 C 474 Sbjct: 289 D 289 >3Q5I-A nrPDB Length = 504 Score = 308 bits (789), Expect = 5e-84, Method: Composition-based stats. Identities = 82/304 (26%), Positives = 143/304 (47%), Gaps = 24/304 (7%) Query: 163 DSMFFDRFLQWKWL---ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEK 219 ++++F + +++ ++ + R LG G +GEV C+ + A K ++K Sbjct: 12 ENLYFQGIAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKK 71 Query: 220 KRIKK----------RKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGG 269 + K K NE +L+ ++ ++ L +E K LV GG Sbjct: 72 SQFDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGG 131 Query: 270 DLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG---HIR 326 +L I N F+E A +IL G+ LH+ N V+RD+KPENILL++ +I+ Sbjct: 132 ELFEQIINRHK--FDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIK 189 Query: 327 ISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFR 386 I D GL+ + +R R+GT Y+APEVL ++Y D W G ++Y ++ G PF Sbjct: 190 IVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFG 248 Query: 387 GRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHP 446 G+ ++ ++V++ + S+EAK + K++LT D +R A E Sbjct: 249 GQNDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCT-----AEEALNSR 303 Query: 447 FFRN 450 + + Sbjct: 304 WIKK 307 >5ES1-A nrPDB Length = 328 Score = 308 bits (788), Expect = 6e-84, Method: Composition-based stats. Identities = 80/289 (27%), Positives = 139/289 (48%), Gaps = 15/289 (5%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 E QP N +R R +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 9 EEQPHVGN-YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVR 66 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L LV+ + G++ ++ + G +E RA F +I+ Sbjct: 67 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKF--RQIV 124 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 + H++N V+RDLK EN+LLD +I+I+D G + + G + G+ Y APE+ Sbjct: 125 SAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPEL 184 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 ++Y G D W LG ++Y ++ G PF G K RE RVL + S + Sbjct: 185 FQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRE----RVLRGKYRVPFYMSTD 240 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPP 464 +SI + L + +R ++ + + N+ ++ E P Sbjct: 241 CESILRRFLVLNPAKRCTL-----EQIMKDKWI-NIGYEGEELKPYTEP 283 >2J90-A nrPDB Length = 304 Score = 307 bits (786), Expect = 1e-83, Method: Composition-based stats. Identities = 80/304 (26%), Positives = 142/304 (46%), Gaps = 25/304 (8%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F ++ + + LG G F V C+ + TGK YA K ++K+R+ Sbjct: 16 ENLYFQSMVE-----------DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRL 64 Query: 223 KKRKG---ESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG 279 + E IL ++ ++ L +E K + L+L +++GG+L + Sbjct: 65 SSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAE-- 122 Query: 280 NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH----IRISDLGLAVK 335 E+ A + +IL G+ LH + + DLKPENI+L D I++ D G+A K Sbjct: 123 KESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHK 182 Query: 336 IPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE 395 I G+ + GT ++APE++N + GL D W +G + Y ++ G SPF G ++ Sbjct: 183 IEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLT 242 Query: 396 EVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR 455 + + +E Y SE AK + LL KD K+R+ A+ H + + + + Sbjct: 243 NISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTI-----AQSLEHSWIKAIRRRN 297 Query: 456 LEAG 459 + Sbjct: 298 VRGE 301 >2V7O-A nrPDB Length = 336 Score = 306 bits (785), Expect = 1e-83, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 130/290 (44%), Gaps = 18/290 (6%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F + ++ + LGKG F V C + + YA K + K++ Sbjct: 16 ENLYFQSMATCTRFT------DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKL 69 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 R + + E +I + +V L + + LV ++ GG+L I + Sbjct: 70 SARDHQKLE-REARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREY 126 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH---IRISDLGLAVKI-PE 338 + E A +IL + +H+ + V+RDLKPEN+LL ++++D GLA+++ E Sbjct: 127 YSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGE 186 Query: 339 GDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD 398 G GT GY++PEVL YG D W G ++Y ++ G PF + +++ Sbjct: 187 QQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK 246 Query: 399 RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + + EAK++ +LT + +R+ A + +HP+ Sbjct: 247 AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRIT-----ADQALKHPWV 291 >3MN3-A nrPDB Length = 271 Score = 306 bits (784), Expect = 2e-83, Method: Composition-based stats. Identities = 68/266 (25%), Positives = 124/266 (46%), Gaps = 13/266 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 ++ + LG+G FG+V TG+ A K + KK + K + E L + Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 ++ L ++KD + +V+ G +L +I E+ A + +I+ +E HR Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQ--RDKMSEQEARRFFQQIISAVEYCHR 121 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-G 363 V+RDLKPEN+LLD++ +++I+D GL+ + +G+ ++ G+ Y APEV++ + Y G Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 D W G ++Y M+ + PF V + + V S A + K + Sbjct: 182 PEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVY----TLPKFLSPGAAGLIKRM 237 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFR 449 L + R+ E+ + +F+ Sbjct: 238 LIVNPLNRISIH-----EIMQDDWFK 258 >3H4J-B nrPDB Length = 336 Score = 306 bits (783), Expect = 2e-83, Method: Composition-based stats. Identities = 74/264 (28%), Positives = 127/264 (48%), Gaps = 13/264 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 + LG+G FG+V T + A K + ++ +KK E L+ + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++ L T + +V+ GG+L +I E+ + +I+C +E HR Sbjct: 71 IIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKR--MTEDEGRRFFQQIICAIEYCHRH 127 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GL 364 V+RDLKPEN+LLDD +++I+D GL+ + +G+ ++ G+ Y APEV+N + Y G Sbjct: 128 KIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLL 424 D W G ++Y M+ G+ PF ++V+ V V S A+S+ + ++ Sbjct: 188 EVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVY----VMPDFLSPGAQSLIRRMI 243 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFF 448 D QR+ Q E++R P+F Sbjct: 244 VADPMQRITIQ-----EIRRDPWF 262 >3BHH-A nrPDB Length = 295 Score = 305 bits (782), Expect = 3e-83, Method: Composition-based stats. Identities = 71/269 (26%), Positives = 124/269 (46%), Gaps = 12/269 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + ++ Y +GKG F V C TG YA K + K++ R + + E +I + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLE-REARICRLLKH 62 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + + LV ++ GG+L I + + E A +IL + H Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCH 120 Query: 304 RENTVYRDLKPENILLDDYGH---IRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNN 359 + V+RDLKPEN+LL ++++D GLA+++ + G GT GY++PEVL Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 + YG D W G ++Y ++ G PF + +++ + + EAK++ Sbjct: 181 EAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 240 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 +LT + +R+ A E +HP+ Sbjct: 241 INQMLTINPAKRIT-----AHEALKHPWV 264 >3ORZ-A nrPDB Length = 316 Score = 305 bits (781), Expect = 4e-83, Method: Composition-based stats. Identities = 96/285 (33%), Positives = 154/285 (54%), Gaps = 12/285 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 F+ ++LG+G F V + AT + YA K LEK+ I K E+ ++ +++ Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 F V L + ++ + L L+ G+L +I +G F+E FY AEI+ LE LH Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIG--SFDETCTRFYTAEIVSALEYLH 154 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL---IRGRVGTVGYMAPEVLNNQ 360 + ++RDLKPENILL++ HI+I+D G A + VGT Y++PE+L + Sbjct: 155 GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEK 214 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 S D W LGC+IY+++ G PFR E + + +++++ E + KF +A+ + Sbjct: 215 SACKSSDLWALGCIIYQLVAGLPPFRAGNEYL----IFQKIIKLEYDFPEKFFPKARDLV 270 Query: 421 KMLLTKDAKQRLGCQE-EGAAEVKRHPFFRNMNFKRLEAGMLDPP 464 + LL DA +RLGC+E EG +K HPFF ++ ++ L PP Sbjct: 271 EKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 313 >5LOH-A nrPDB Length = 341 Score = 304 bits (779), Expect = 7e-83, Method: Composition-based stats. Identities = 94/314 (29%), Positives = 161/314 (51%), Gaps = 24/314 (7%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 +P + F + + +G FG+V Q GK+YA K ++K + + E+ L Sbjct: 31 KPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDAL 88 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 S F+V+L Y+ ++ + + LV+ + GGD+K ++ G F+EE A+ Y +E+ Sbjct: 89 ALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYG--YFDEEMAVKYISEVALA 146 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-------LIRGRVGTVGY 351 L+ LHR ++RDLKP+N+L+ + GHI+++D GL+ D R GT Y Sbjct: 147 LDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDY 206 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 +APE+L + +G + D+W LG ++E + G PF + + + +R + E K Sbjct: 207 LAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGE-EK 265 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRA 471 S+ A+S ++LLT D +R G E+KRHP F +++++ L+ + PF+P P Sbjct: 266 LSDNAQSAVEILLTIDDTKRAGM-----KELKRHPLFSDVDWENLQHQTM--PFIPQP-- 316 Query: 472 VYCKDVLDIEQFST 485 D D F Sbjct: 317 ---DDETDTSYFEA 327 >3SOA-A nrPDB Length = 444 Score = 303 bits (775), Expect = 2e-82, Method: Composition-based stats. Identities = 69/271 (25%), Positives = 122/271 (45%), Gaps = 12/271 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 ++ + LGKG F V C G+ YA + K++ R + + E +I + Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLE-REARICRLLKH 69 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + + L+ ++ GG+L I + + E A +IL + H Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCH 127 Query: 304 RENTVYRDLKPENILLDDYGH---IRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNN 359 + V+R+LKPEN+LL ++++D GLA+++ E G GT GY++PEVL Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 YG D W G ++Y ++ G PF + +++ + + EAK + Sbjct: 188 DPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 247 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 +LT + +R+ AAE +HP+ + Sbjct: 248 INKMLTINPSKRIT-----AAEALKHPWISH 273 >5KZ7-A nrPDB Length = 346 Score = 301 bits (772), Expect = 4e-82, Method: Composition-based stats. Identities = 75/273 (27%), Positives = 135/273 (49%), Gaps = 14/273 (5%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + QP N +R + +GKG F +V + TGK A K ++K ++ + + E + Sbjct: 27 DEQPHIGN-YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVR 84 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L LV+ +GG++ ++ G +E RA F +I+ Sbjct: 85 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 142 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 ++ H++ V+RDLK EN+LLD +I+I+D G + + G+ + G+ Y APE+ Sbjct: 143 SAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPEL 202 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 ++Y G D W LG ++Y ++ G PF G+ K RE RVL + S + Sbjct: 203 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRE----RVLRGKYRIPFYMSTD 258 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 +++ K L + +R ++ + + Sbjct: 259 CENLLKKFLILNPSKR-----GTLEQIMKDRWM 286 >3D2K-A nrPDB Length = 272 Score = 301 bits (770), Expect = 8e-82, Method: Composition-based stats. Identities = 77/268 (28%), Positives = 121/268 (45%), Gaps = 12/268 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 T F R LGKG FG V + R + + A K L K +++K E E +I + Sbjct: 10 TLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHL 69 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 ++ L + + L+L G + + + F+E+R Y E+ L Sbjct: 70 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR--FDEQRTATYITELANALSY 127 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 H + ++RD+KPEN+LL G ++I+D G +V P GT+ Y+ PE++ + Sbjct: 128 CHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPS-SRRTTLCGTLDYLPPEMIEGRM 186 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 + D W LG L YE + G PF E +E RR+ E + +E A+ + Sbjct: 187 HDEKVDLWSLGVLCYEFLVGMPPF----EAHTYQETYRRISRVEFTFPDFVTEGARDLIS 242 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 LL +A QRL AEV HP+ + Sbjct: 243 RLLKHNASQRLTL-----AEVLEHPWIK 265 >4REW-A nrPDB Length = 540 Score = 300 bits (769), Expect = 9e-82, Method: Composition-based stats. Identities = 70/271 (25%), Positives = 125/271 (46%), Gaps = 12/271 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V + LG G FG+V + TG A K L +++I+ E Q L+ Sbjct: 3 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 62 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 ++ L T + +V+ ++GG+L +I G +E+ + +IL G++ Sbjct: 63 FRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVD 120 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 HR V+RDLKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 180 Query: 361 RY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 Y G D W G ++Y ++ G PF +++ + T + S+ Sbjct: 181 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYT----PQYLNPSVISL 236 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 K +L D +R +++ H +F+ Sbjct: 237 LKHMLQVDPMKRASI-----KDIREHEWFKQ 262 >2YAB-A nrPDB Length = 361 Score = 300 bits (769), Expect = 1e-81, Method: Composition-based stats. Identities = 83/305 (27%), Positives = 147/305 (48%), Gaps = 14/305 (4%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG---ESMALNE 234 +Q ++ + LG G F V C+ ++TG YA K ++K++ + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIERE 65 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 IL +V ++ L YE + + L+L +++GG+L + EE A + + Sbjct: 66 VSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQ 123 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVG 350 IL G+ LH + + DLKPENI+L D HI++ D GLA +I +G + GT Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 ++APE++N + GL D W +G + Y ++ G SPF G ++ + + +E + Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFS 243 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPR 470 + SE AK + LL K+ ++RL Q E RHP+ ++ ++ + + + Sbjct: 244 QTSELAKDFIRKLLVKETRKRLTIQ-----EALRHPWITPVDTQQAMVRRESVVNLENFK 298 Query: 471 AVYCK 475 Y + Sbjct: 299 KQYVR 303 >2QNJ-A nrPDB Length = 328 Score = 300 bits (768), Expect = 1e-81, Method: Composition-based stats. Identities = 71/273 (26%), Positives = 133/273 (48%), Gaps = 14/273 (5%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 6 DEQPHIGN-YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVR 63 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L L++ +GG++ ++ G +E+ A +I+ Sbjct: 64 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR--MKEKEARSKFRQIV 121 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 ++ H++ V+RDLK EN+LLD +I+I+D G + + G + G+ Y APE+ Sbjct: 122 SAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPEL 181 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 ++Y G D W LG ++Y ++ G PF G+ K RE RVL + S + Sbjct: 182 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRE----RVLRGKYRIPFYMSTD 237 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 +++ K L + +R ++ + + Sbjct: 238 CENLLKRFLVLNPIKR-----GTLEQIMKDRWI 265 >3TAC-A nrPDB Length = 361 Score = 299 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 79/278 (28%), Positives = 129/278 (46%), Gaps = 14/278 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG--ESMALNEKQILEK 240 ++ + V+GKG F V C R TG+ +A K ++ + G E I Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF--EEERALFYAAEILCG 298 + +V L Y + L +V M+G DL F I + GF E A Y +IL Sbjct: 85 LKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEA 144 Query: 299 LEDLHRENTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRG-RVGTVGYMAP 354 L H N ++RD+KP +LL ++ +++ G+A+++ E L+ G RVGT +MAP Sbjct: 145 LRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAP 204 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE 414 EV+ + YG D WG G +++ ++ G PF G KE+ E + + + SE Sbjct: 205 EVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKER-LFEGIIKGKYKMNPRQWSHISE 263 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 AK + + +L D +R+ E HP+ + + Sbjct: 264 SAKDLVRRMLMLDPAERITVY-----EALNHPWLKERD 296 >3GUB-A nrPDB Length = 295 Score = 299 bits (767), Expect = 2e-81, Method: Composition-based stats. Identities = 90/296 (30%), Positives = 140/296 (47%), Gaps = 15/296 (5%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG---ESMALNE 234 RQ + + LG G F V C+ ++TG YA K ++K+R K + E Sbjct: 5 RQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIERE 64 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 IL+++ V+ L YE K + L+ ++ GG+L + EE A + + Sbjct: 65 VSILKEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAE--KESLTEEEATEFLKQ 122 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGH----IRISDLGLAVKIPEGDLIRGRVGTVG 350 IL G+ LH + DLKPENI+L D I+I D GLA KI G+ + GT Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 ++APE++N + GL D W +G + Y ++ G SPF G ++ V E E+ Y Sbjct: 183 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFS 242 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKR-LEAGMLDPPF 465 S AK + LL KD K+R+ Q+ +HP+ + + ++ L + P F Sbjct: 243 NTSALAKDFIRRLLVKDPKKRMTIQDS-----LQHPWIKPKDTQQALSSAWSHPQF 293 >4RED-A nrPDB Length = 351 Score = 299 bits (767), Expect = 2e-81, Method: Composition-based stats. Identities = 70/271 (25%), Positives = 125/271 (46%), Gaps = 12/271 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V + LG G FG+V + TG A K L +++I+ E Q L+ Sbjct: 11 VKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKL 70 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 ++ L T + +V+ ++GG+L +I G +E+ + +IL G++ Sbjct: 71 FRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVD 128 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 HR V+RDLKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 Query: 361 RY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 Y G D W G ++Y ++ G PF +++ + T + S+ Sbjct: 189 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYT----PQYLNPSVISL 244 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 K +L D +R +++ H +F+ Sbjct: 245 LKHMLQVDPMKRASI-----KDIREHEWFKQ 270 >5YKS-A nrPDB Length = 377 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 68/269 (25%), Positives = 129/269 (47%), Gaps = 13/269 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 + + LG+G F V + TG+ A K ++K ++ E + ++ V Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 95 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 +V L +T+ L L+L + +GGD+ +I G E+ A Y A+I+ + H+ Sbjct: 96 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKH-EEGLNEDLAKKYFAQIVHAISYCHKL 154 Query: 306 NTVYRDLKPEN-ILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYG- 363 + V+RDLKPEN + + G ++++D G + K G + G++ Y APE+L Y Sbjct: 155 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 + D W LG +++ ++ GQ PF+ + E +++ + S+E K + + Sbjct: 215 PAVDIWSLGVILFMLVCGQPPFQEANDS----ETLTMIMDCKYTVPSHVSKECKDLITRM 270 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 L +D K+R E++ HP+ + ++ Sbjct: 271 LQRDPKRRASL-----EEIENHPWLQGVD 294 >2YCR-A nrPDB Length = 323 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 80/291 (27%), Positives = 137/291 (47%), Gaps = 20/291 (6%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI-----KKRKGESMALNEKQI 237 ++ + + LG G GEV R T K A K + K++ ++ E +I Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 L+K+N ++ + ++ +D +VL +M GG+L + +GN +E Y ++L Sbjct: 69 LKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKV--VGNKRLKEATCKLYFYQMLL 125 Query: 298 GLEDLHRENTVYRDLKPENILLD---DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAP 354 ++ LH ++RDLKPEN+LL + I+I+D G + + E L+R GT Y+AP Sbjct: 126 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAP 185 Query: 355 EVL---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV-KREEVDRRVLETEEVYSH 410 EVL Y + D W LG +++ + G PF + +V ++++ Sbjct: 186 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGML 461 + SE+A + K LL D K R E RHP+ ++ + KR +L Sbjct: 246 EVSEKALDLVKKLLVVDPKARFTT-----EEALRHPWLQDEDMKRKFQDLL 291 >2VD5-A nrPDB Length = 412 Score = 298 bits (763), Expect = 4e-81, Method: Composition-based stats. Identities = 104/347 (29%), Positives = 166/347 (47%), Gaps = 24/347 (6%) Query: 149 VHEYLRGEPFHEYLDSMFFDRFLQWK-----WLERQPVTKNTFRQYRVLGKGGFGEVCAC 203 VH+ L + + FLQW L+ + ++ F +V+G+G F EV Sbjct: 24 VHQELGASELAQ---DKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVV 80 Query: 204 QVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVL 263 +++ TG++YA K + K + KR S E+ +L + +++ L +A++ ++ L LV+ Sbjct: 81 KMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVM 140 Query: 264 TIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG 323 GGDL + G E A FY AEI+ ++ +HR V+RD+KP+NILLD G Sbjct: 141 EYYVGGDLLTLLSKFGER-IPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCG 199 Query: 324 HIRISDLGLAVKIPEGDLIRGR--VGTVGYMAPEVLN-------NQRYGLSPDYWGLGCL 374 HIR++D G +K+ +R VGT Y++PE+L YG D+W LG Sbjct: 200 HIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVF 259 Query: 375 IYEMIEGQSPFRGRKEKVKREEV-DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLG 433 YEM GQ+PF ++ + + + EEA+ + LL + RLG Sbjct: 260 AYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLG 318 Query: 434 CQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480 GA + + HPFF +++ L + PPF PD D+ Sbjct: 319 --RGGAGDFRTHPFFFGLDWDGLRDSV--PPFTPDFEGATDTCNFDL 361 >5WAX-A nrPDB Length = 310 Score = 298 bits (763), Expect = 5e-81, Method: Composition-based stats. Identities = 72/286 (25%), Positives = 117/286 (40%), Gaps = 20/286 (6%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + R +G G FG + RA G++ A K +E+ K + E + Sbjct: 9 DGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERG----EKIDENVQREIINHRSL 64 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 ++ T L +V+ +GG+L I N G F E+ A F+ +++ G+ Sbjct: 65 RHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSY 122 Query: 302 LHRENTVYRDLKPENILLD--DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 H +RDLK EN LLD ++I D G + + VGT Y+APEVL Sbjct: 123 CHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK 182 Query: 360 QRYGLSP-DYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH--KFSEEA 416 + Y D W G +Y M+ G PF E + +R+L + S E Sbjct: 183 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPEC 242 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLD 462 + + + + R+ E++ HP+F K L A ++D Sbjct: 243 QDLISRIFVANPATRITI-----PEIRNHPWF----LKNLPADLMD 279 >4CFH-A nrPDB Length = 493 Score = 298 bits (762), Expect = 6e-81, Method: Composition-based stats. Identities = 72/285 (25%), Positives = 128/285 (44%), Gaps = 12/285 (4%) Query: 167 FDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRK 226 F + K V + LG G FG+V + TG A K L +++I+ Sbjct: 16 FQGPMAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLD 75 Query: 227 GESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286 E Q L+ ++ L T + +V+ ++GG+L +I G +E+ Sbjct: 76 VVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR--LDEK 133 Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV 346 + +IL G++ HR V+RDLKPEN+LLD + + +I+D GL+ + +G+ +R Sbjct: 134 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC 193 Query: 347 GTVGYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE 405 G+ Y APEV++ + Y G D W G ++Y ++ G PF +++ + T Sbjct: 194 GSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYT- 252 Query: 406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + S+ K +L D +R +++ H +F+ Sbjct: 253 ---PQYLNPSVISLLKHMLQVDPMKRATI-----KDIREHEWFKQ 289 >4CFF-A nrPDB Length = 571 Score = 297 bits (761), Expect = 9e-81, Method: Composition-based stats. Identities = 72/285 (25%), Positives = 125/285 (43%), Gaps = 12/285 (4%) Query: 167 FDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRK 226 F + K V + LG G FG+V + + TG A K L +++I+ Sbjct: 16 FQGPMAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD 75 Query: 227 GESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286 E Q L+ ++ L T +V+ ++GG+L +I G EE Sbjct: 76 VVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEM 133 Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV 346 A +IL ++ HR V+RDLKPEN+LLD + + +I+D GL+ + +G+ +R Sbjct: 134 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC 193 Query: 347 GTVGYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE 405 G+ Y APEV++ + Y G D W G ++Y ++ G PF +++ V Sbjct: 194 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP 253 Query: 406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 E + + + +L D +R +++ H +F+ Sbjct: 254 EYLNRSVAT----LLMHMLQVDPLKRATI-----KDIREHEWFKQ 289 >2A27-A nrPDB Length = 321 Score = 297 bits (760), Expect = 1e-80, Method: Composition-based stats. Identities = 83/282 (29%), Positives = 140/282 (49%), Gaps = 14/282 (4%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG---ESMALNE 234 +Q ++ + LG G F V C+ ++TG YA K ++K++ + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 IL +V V+ L YE + + L+L +++GG+L + EE A + + Sbjct: 66 VSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQ 123 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVG 350 IL G+ LH + + DLKPENI+L D HI++ D GLA +I +G + GT Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 ++APE++N + GL D W +G + Y ++ G SPF G ++ + + +E + Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFS 243 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 + SE AK + LL K+ ++RL Q E RHP+ ++ Sbjct: 244 QTSELAKDFIRKLLVKETRKRLTIQ-----EALRHPWITPVD 280 >1ZWS-A nrPDB Length = 288 Score = 297 bits (760), Expect = 1e-80, Method: Composition-based stats. Identities = 83/282 (29%), Positives = 139/282 (49%), Gaps = 14/282 (4%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG---ESMALNE 234 +Q ++ + LG G F V C+ ++TG YA K ++K++ + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 IL +V V+ L YE + + L+L +++GG+L + EE A + + Sbjct: 66 VSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQ 123 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVG 350 IL G+ LH + + DLKPENI+L D HI++ D GLA +I +G + GT Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 ++APE++N + GL D W +G + Y ++ G SPF G ++ + + +E + Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFS 243 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 SE AK + LL K+ ++RL Q E RHP+ ++ Sbjct: 244 HTSELAKDFIRKLLVKETRKRLTIQ-----EALRHPWITPVD 280 >4CZT-A nrPDB Length = 464 Score = 296 bits (759), Expect = 1e-80, Method: Composition-based stats. Identities = 73/270 (27%), Positives = 129/270 (47%), Gaps = 15/270 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + R LG+G F +V + G A K ++K+++ K K + E ++ + Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 V+ + +K + VL + GG+L I + G +E+ A Y +++ ++ H Sbjct: 72 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYCHS 129 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMAPEVLNNQR 361 +RDLKPEN+LLD G +++SD GL+ ++ E L+ GT Y+APEV+NN+ Sbjct: 130 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 362 Y-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y G D W G +++ ++ G PF E + +++ + E FS AK + Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPF----EDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 245 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 K +L + R+ AEV + +F+ Sbjct: 246 KRILDPNPATRITF-----AEVIENEWFKK 270 >4UZD-A nrPDB Length = 287 Score = 296 bits (758), Expect = 2e-80, Method: Composition-based stats. Identities = 71/265 (26%), Positives = 117/265 (44%), Gaps = 12/265 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 F R LGKG FG V + + + + A K L K +++K E E +I + Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L + + L+L G + + + F+E+R Y E+ L H Sbjct: 68 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCH 125 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYG 363 + ++RD+KPEN+LL G ++I+D G +V P GT+ Y+ PE++ + + Sbjct: 126 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPS-SRRTTLCGTLDYLPPEMIEGRMHD 184 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 D W LG L YE + G+ PF E +E +R+ E + +E A+ + L Sbjct: 185 EKVDLWSLGVLCYEFLVGKPPF----EANTYQETYKRISRVEFTFPDFVTEGARDLISRL 240 Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFF 448 L + QR EV HP+ Sbjct: 241 LKHNPSQR-----PMLREVLEHPWI 260 >5EZV-A nrPDB Length = 560 Score = 295 bits (756), Expect = 3e-80, Method: Composition-based stats. Identities = 70/272 (25%), Positives = 122/272 (44%), Gaps = 12/272 (4%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 V + LG G FG+V + + TG A K L +++I+ E Q L+ Sbjct: 24 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 83 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 ++ L T +V+ ++GG+L +I G EE A +IL + Sbjct: 84 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAV 141 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 + HR V+RDLKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ Sbjct: 142 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 201 Query: 360 QRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + Y G D W G ++Y ++ G PF +++ V E + + Sbjct: 202 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT---- 257 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + +L D +R +++ H +F+ Sbjct: 258 LLMHMLQVDPLKRATI-----KDIREHEWFKQ 284 >2YZA-A nrPDB Length = 276 Score = 295 bits (755), Expect = 4e-80, Method: Composition-based stats. Identities = 70/272 (25%), Positives = 122/272 (44%), Gaps = 12/272 (4%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 V + LG G FG+V + + TG A K L +++I+ E Q L+ Sbjct: 7 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 66 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 ++ L T +V+ ++GG+L +I G EE A +IL + Sbjct: 67 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAV 124 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 + HR V+RDLKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ Sbjct: 125 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISG 184 Query: 360 QRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + Y G D W G ++Y ++ G PF +++ V E + + Sbjct: 185 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT---- 240 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + +L D +R +++ H +F+ Sbjct: 241 LLMHMLQVDPLKRATI-----KDIREHEWFKQ 267 >3I6U-A nrPDB Length = 419 Score = 295 bits (755), Expect = 4e-80, Method: Composition-based stats. Identities = 79/291 (27%), Positives = 137/291 (47%), Gaps = 20/291 (6%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI-----KKRKGESMALNEKQI 237 ++ + + LG G GEV R T K A + + K++ ++ E +I Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 L+K+N ++ + ++ +D +VL +M GG+L + +GN +E Y ++L Sbjct: 194 LKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKV--VGNKRLKEATCKLYFYQMLL 250 Query: 298 GLEDLHRENTVYRDLKPENILLD---DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAP 354 ++ LH ++RDLKPEN+LL + I+I+D G + + E L+R GT Y+AP Sbjct: 251 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAP 310 Query: 355 EVL---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV-KREEVDRRVLETEEVYSH 410 EVL Y + D W LG +++ + G PF + +V ++++ Sbjct: 311 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGML 461 + SE+A + K LL D K R E RHP+ ++ + KR +L Sbjct: 371 EVSEKALDLVKKLLVVDPKARFTT-----EEALRHPWLQDEDMKRKFQDLL 416 >2BPM-A nrPDB Length = 309 Score = 294 bits (754), Expect = 5e-80, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 134/311 (43%), Gaps = 35/311 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V F++ +G+G +G V + + TG++ A K++ + S A+ E +L++ Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKE 62 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 +N +V L T++ L LV + DLK + G Y ++L GL Sbjct: 63 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNN 359 H ++RDLKP+N+L++ G I+++D GLA V T+ Y APE+L Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 181 Query: 360 -QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS----- 413 + Y + D W LGC+ EM+ ++ F G E + + R + +EV + Sbjct: 182 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 241 Query: 414 --------------------EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNF 453 E+ +S+ +L D +R+ A HPFF+++ Sbjct: 242 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDVT- 295 Query: 454 KRLEAGMLDPP 464 K + L+ P Sbjct: 296 KPVPHLRLERP 306 >5XZW-A nrPDB Length = 471 Score = 294 bits (752), Expect = 9e-80, Method: Composition-based stats. Identities = 79/281 (28%), Positives = 129/281 (45%), Gaps = 25/281 (8%) Query: 184 NTFRQY-RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 F V+G+G F V R TGK +A K + K+++ E ++L+K+N Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT--RELEVLQKLN 252 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +V L YE ++ +V+ ++GGDL + G G E+ + +IL ++ + Sbjct: 253 HPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG--EDAGREISRQILTAIKYI 310 Query: 303 HRENTVYRDLKPENILL--DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 H +RDLKP+NIL+ DD ++I+D GLA G ++ GT+ Y+APEV+ + Sbjct: 311 HSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 370 Query: 361 -------------RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 Y D W +GCL+Y ++ G PF G + +++ R + Sbjct: 371 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPL 430 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + SEEA+ LL D R AA+ HP+ Sbjct: 431 KDFRISEEARDFIDSLLQVDPNNR-----STAAKALNHPWI 466 >4JXF-A nrPDB Length = 266 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 73/267 (27%), Positives = 122/267 (45%), Gaps = 11/267 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 F+ +LGKG F V + TG A K ++KK + K NE +I ++ Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L +E + + LVL + + G++ ++ N P F E A + +I+ G+ LH Sbjct: 67 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKP-FSENEARHFMHQIITGMLYLH 125 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQRY 362 ++RDL N+LL +I+I+D GLA ++ + GT Y++PE+ + Sbjct: 126 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 185 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKM 422 GL D W LGC+ Y ++ G+ PF + + +V+ + S EAK + Sbjct: 186 GLESDVWSLGCMFYTLLIGRPPF----DTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQ 241 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFFR 449 LL ++ RL V HPF Sbjct: 242 LLRRNPADRLSLSS-----VLDHPFMS 263 >3UC3-A nrPDB Length = 361 Score = 291 bits (744), Expect = 7e-79, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 123/313 (39%), Gaps = 23/313 (7%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + + +G G FG + + T ++ A K +E+ + E + Sbjct: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQ----REIINHRSL 73 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +V T L +++ +GG+L I N G F E+ A F+ ++L G+ Sbjct: 74 RHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSY 131 Query: 302 LHRENTVYRDLKPENILLDDY--GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 H +RDLK EN LLD ++I D G + + VGT Y+APEVL Sbjct: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 Query: 360 QRYGLS-PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK--FSEEA 416 Q Y D W G +Y M+ G PF +E + +R+L + S E Sbjct: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPEC 251 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKD 476 + + D R+ E+K H +F K L A +++ + + + + Sbjct: 252 CHLISRIFVADPATRISI-----PEIKTHSWF----LKNLPADLMNE---SNTGSQFQEP 299 Query: 477 VLDIEQFSTVKGV 489 ++ T+ + Sbjct: 300 EQPMQSLDTIMQI 312 >2W4O-A nrPDB Length = 349 Score = 290 bits (743), Expect = 9e-79, Method: Composition-based stats. Identities = 81/291 (27%), Positives = 132/291 (45%), Gaps = 24/291 (8%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + + F LG+G V C+ + T K YA K L+K KK + E +L Sbjct: 48 RDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKK-----IVRTEIGVL 102 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 +++ ++ L +ET + LVL ++ GG+L I G + E A +IL Sbjct: 103 LRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKG--YYSERDAADAVKQILEA 160 Query: 299 LEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 + LH V+RDLKPEN+L ++I+D GL+ + L++ GT GY APE Sbjct: 161 VAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPE 220 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY----SHK 411 +L YG D W +G + Y ++ G PF + + + RR+L E + + Sbjct: 221 ILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGD---QFMFRRILNCEYYFISPWWDE 277 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF--RNMNFKRLEAGM 460 S AK + + L+ D K+RL + +HP+ + NF ++ Sbjct: 278 VSLNAKDLVRKLIVLDPKKRLTTF-----QALQHPWVTGKAANFVHMDTAQ 323 >3F3Z-A nrPDB Length = 277 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 67/268 (25%), Positives = 119/268 (44%), Gaps = 14/268 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 + +G+G +GEV + T A K++ K + + E +I++ ++ Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLDHPN 67 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++ L +E + LV+ + GG+L + + F E A ++L + H+ Sbjct: 68 IIRLYETFEDNTDIYLVMELCTGGELFERV--VHKRVFRESDAARIMKDVLSAVAYCHKL 125 Query: 306 NTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 N +RDLKPEN L +++ D GLA + G ++R +VGT Y++P+VL Y Sbjct: 126 NVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG-LY 184 Query: 363 GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKM 422 G D W G ++Y ++ G PF + ++ E S +A+S+ + Sbjct: 185 GPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 LLTK KQR+ + H +F Sbjct: 245 LLTKSPKQRITSL-----QALEHEWFEK 267 >5JZN-A nrPDB Length = 280 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 80/273 (29%), Positives = 127/273 (46%), Gaps = 17/273 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 ++ R +G G F V C R+T + YA K ++K + R E M NE IL +V Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKC--RGKEHMIQNEVSILRRVKH 76 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +V L + L LV+ ++ GGDL I + + E A + ++ LH Sbjct: 77 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNK--YTERDASGMLYNLASAIKYLH 134 Query: 304 RENTVYRDLKPENILL----DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 N V+RD+KPEN+L+ D +++ D GLA + + GT Y+APE++ Sbjct: 135 SLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAE 192 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFR--GRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 YGL D W G + Y ++ G PFR G ++V +++ ++ Y S+ AK Sbjct: 193 TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAK 252 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + M+L D QR A +V HP+ + Sbjct: 253 ELITMMLLVDVDQRFS-----AVQVLEHPWVND 280 >1PHK-A nrPDB Length = 298 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 76/288 (26%), Positives = 125/288 (43%), Gaps = 20/288 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEK------KRIKKRKGESMALNEKQI 237 + +LG+G V C + T K YA K ++ + ++ L E I Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 238 LEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 L KV ++ L YET LV +M G+L ++ E+ +L Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTE--KVTLSEKETRKIMRALL 134 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 + LH+ N V+RDLKPENILLDD +I+++D G + ++ G+ +R GT Y+APE+ Sbjct: 135 EVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEI 194 Query: 357 L------NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 + N+ YG D W G ++Y ++ G PF RK+ + + + Sbjct: 195 IECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWD 254 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEA 458 +S+ K + L ++R A E HPFF+ + + Sbjct: 255 DYSDTVKDLVSRFLVVQPQKRYT-----AEEALAHPFFQQYVVEEVRH 297 >3COM-A nrPDB Length = 314 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 75/283 (26%), Positives = 118/283 (41%), Gaps = 16/283 (5%) Query: 172 QWKWLERQPVTK---NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGE 228 Q K L+ +TK F LG+G +G V + TG++ A K++ Sbjct: 14 QLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV-----ESDL 68 Query: 229 SMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA 288 + E I+++ +S VV +Y L +V+ G + I + N E+ Sbjct: 69 QEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEDEI 127 Query: 289 LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV-G 347 L GLE LH ++RD+K NILL+ GH +++D G+A ++ + R V G Sbjct: 128 ATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIG 187 Query: 348 TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 T +MAPEV+ Y D W LG EM EG+ P+ + Sbjct: 188 TPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMI-PTNPPPTFR 246 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 +S+ K L K +QR A ++ +HPF R+ Sbjct: 247 KPELWSDNFTDFVKQCLVKSPEQR-----ATATQLLQHPFVRS 284 >2Y7J-A nrPDB Length = 365 Score = 289 bits (739), Expect = 3e-78, Method: Composition-based stats. Identities = 82/302 (27%), Positives = 130/302 (43%), Gaps = 22/302 (7%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYR---VLGKGGFGEVCACQVRATGKMYACKRLEK 219 ++++F L K +++Y V+G+G V C RATG +A K +E Sbjct: 70 ENLYFQSMGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEV 129 Query: 220 -----KRIKKRKGESMALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKF 273 + + E IL +V ++ L +YE+ + LV +M G+L Sbjct: 130 TAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFD 189 Query: 274 HIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA 333 ++ E+ +L + LH N V+RDLKPENILLDD IR+SD G + Sbjct: 190 YLTE--KVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFS 247 Query: 334 VKIPEGDLIRGRVGTVGYMAPEVLNNQ------RYGLSPDYWGLGCLIYEMIEGQSPFRG 387 + G+ +R GT GY+APE+L YG D W G +++ ++ G PF Sbjct: 248 CHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWH 307 Query: 388 RKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 R++ + + + S K + LL D + RL A + +HPF Sbjct: 308 RRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLT-----AEQALQHPF 362 Query: 448 FR 449 F Sbjct: 363 FE 364 >1KOB-A nrPDB Length = 387 Score = 288 bits (738), Expect = 4e-78, Method: Composition-based stats. Identities = 81/294 (27%), Positives = 138/294 (46%), Gaps = 19/294 (6%) Query: 167 FDRFLQ--WKWLERQPVTK------NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE 218 +D+F + WK QPV + + LG G FG V C +ATG+++ K + Sbjct: 26 YDKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFIN 85 Query: 219 KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM 278 + NE I+ +++ ++NL A+E K + L+L ++GG+L I Sbjct: 86 TPYPLDK---YTVKNEISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRI-AA 141 Query: 279 GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDY--GHIRISDLGLAVKI 336 + E + Y + GL+ +H + V+ D+KPENI+ + ++I D GLA K+ Sbjct: 142 EDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKL 201 Query: 337 PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE 396 ++++ T + APE+++ + G D W +G L Y ++ G SPF G + + Sbjct: 202 NPDEIVKVTTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQN 261 Query: 397 VDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 V R E +E S EAK K LL K+ ++RL + HP+ + Sbjct: 262 VKRCDWEFDEDAFSSVSPEAKDFIKNLLQKEPRKRLTVH-----DALEHPWLKG 310 >3ZUT-A nrPDB Length = 362 Score = 286 bits (732), Expect = 2e-77, Method: Composition-based stats. Identities = 74/334 (22%), Positives = 129/334 (38%), Gaps = 21/334 (6%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + + +G G FG + + + ++ A K +E+ K + E + Sbjct: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EKIDENVKREIINHRSL 72 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +V T L +V+ +GG+L I N G F E+ A F+ +++ G+ Sbjct: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSY 130 Query: 302 LHRENTVYRDLKPENILLDDY--GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 H +RDLK EN LLD ++I G + + VGT Y+APEVL Sbjct: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK 190 Query: 360 QRYGLSP-DYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH--KFSEEA 416 + Y D W G +Y M+ G PF +E + R+L + S E Sbjct: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF-RNMNFKRLEAGMLDPPFVPDPRAVYCK 475 + + + D +R+ E++ H +F +N+ + + F D + Sbjct: 251 RHLISRIFVADPAKRISI-----PEIRNHEWFLKNLPADLMNDNTMTTQF--DESDQPGQ 303 Query: 476 DVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSI 509 + +I Q V + + TGS+ I Sbjct: 304 SIEEIMQIIAEATVP--PAGTQNLNHYLTGSLDI 335 >4YNZ-A nrPDB Length = 342 Score = 286 bits (732), Expect = 2e-77, Method: Composition-based stats. Identities = 78/309 (25%), Positives = 134/309 (43%), Gaps = 23/309 (7%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 +R + LGKG G V T + A K + ++++ E IL+ + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPH 70 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 V+ L YE K L LVL ++GG+L ++ G + A + +I+ L+ H Sbjct: 71 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR--LTPKEARKFFRQIISALDFCHSH 128 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GL 364 + +RDLKPEN+LLD+ +IRI+D G+A L+ G+ Y PEV+ ++Y G Sbjct: 129 SICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 188 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLL 424 D W G +++ ++ G PF + E+V R V H + +S+ + ++ Sbjct: 189 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHM----PHFIPPDCQSLLRGMI 244 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFS 484 DA +RL +++H ++ + P P PR V + + Sbjct: 245 EVDAARRLTL-----EHIQKHIWY-------IGGKNEPEPEQPIPRKVQIRS---LPSLE 289 Query: 485 TVKGVNLDH 493 + LD Sbjct: 290 DIDPDVLDS 298 >4PDS-A nrPDB Length = 347 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 77/282 (27%), Positives = 129/282 (45%), Gaps = 25/282 (8%) Query: 184 NTFRQY-RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 F V+G+G F V R TGK ++ K + K+++ E ++L+K+N Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVT--RELEVLQKLN 87 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +V L YE ++ +V+ ++GGDL + G G E+ + +IL ++ + Sbjct: 88 HPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG--EDAGREISRQILTAIKYI 145 Query: 303 HRENTVYRDLKPENILL--DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 H +RDLKP+NIL+ DD ++I+ GLA G ++ GT+ Y+APEV+ + Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 205 Query: 361 -------------RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 Y D W +GCL+Y ++ G PF G + +++ R + Sbjct: 206 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPL 265 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 + SEEA+ LL D R AA+ HP+ + Sbjct: 266 KDFRISEEARDFIDSLLQVDPNNR-----STAAKALNHPWIK 302 >6BXI-A nrPDB Length = 333 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 88/338 (26%), Positives = 147/338 (43%), Gaps = 48/338 (14%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 F +V+G+G FGEV Q + TG +YA K L K + +++ E+ IL + +S Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 +VV + Y+++ K L L++ + GGD+ + M EE FY AE + ++ +H Sbjct: 66 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLL--MKKDTLTEEETQFYIAETVLAIDSIH 123 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLA---VKIPEGDLIR----------------- 343 + ++RD+KP+N+LLD GH+++SD GL K + R Sbjct: 124 QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 183 Query: 344 ----------------GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 VGT Y+APEV Y D+W LG ++YEM+ G PF Sbjct: 184 KRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS 243 Query: 388 RKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 + ++V SE+AK + + + R+G G E+K + F Sbjct: 244 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCC-EWEHRIGA--PGVEEIKSNSF 300 Query: 448 FRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFST 485 F ++++ + P ++ K + D F Sbjct: 301 FEGVDWEHIRER-------PAAISIEIKSIDDTSNFDE 331 >2X4F-A nrPDB Length = 373 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 73/264 (27%), Positives = 130/264 (49%), Gaps = 11/264 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 +LG G FG+V C+ ATG A K ++ + +K ++ NE ++ +++ ++ L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVK---NEISVMNQLDHANLIQL 151 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 A+E+K+ + LV+ ++GG+L I + + E + + +I G+ +H+ ++ Sbjct: 152 YDAFESKNDIVLVMEYVDGGELFDRIID-ESYNLTELDTILFMKQICEGIRHMHQMYILH 210 Query: 310 RDLKPENILLDDY--GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD 367 DLKPENIL + I+I D GLA + + ++ GT ++APEV+N D Sbjct: 211 LDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTD 270 Query: 368 YWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKD 427 W +G + Y ++ G SPF G + + + E+ SEEAK LL K+ Sbjct: 271 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 330 Query: 428 AKQRLGCQEEGAAEVKRHPFFRNM 451 R+ A+E +HP+ + Sbjct: 331 KSWRIS-----ASEALKHPWLSDH 349 >5J5T-A nrPDB Length = 370 Score = 285 bits (729), Expect = 4e-77, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 134/310 (43%), Gaps = 15/310 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ F + +G G +G+V + TG++ A K ++ ++ + ++ E +++ Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIK---LEPGEDFAVVQQEIIMMKDC 58 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +V +Y +D L + + GG L+ + G E + + + E L GL Sbjct: 59 KHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP--LSELQIAYVSRETLQGLYY 116 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRVGTVGYMAPEVL--- 357 LH + ++RD+K NILL D GH++++D G++ +I + +GT +MAPEV Sbjct: 117 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVE 176 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH-KFSEEA 416 Y D W +G E+ E Q P + + + ++ K+S Sbjct: 177 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 236 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKD 476 KM LTK+ K+R A ++ +HPF + L +LD PD + D Sbjct: 237 HHFVKMALTKNPKKR-----PTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFD 291 Query: 477 VLDIEQFSTV 486 D E V Sbjct: 292 DDDPEPLVAV 301 >4C0T-A nrPDB Length = 974 Score = 284 bits (727), Expect = 8e-77, Method: Composition-based stats. Identities = 93/322 (28%), Positives = 162/322 (50%), Gaps = 26/322 (8%) Query: 177 ERQPVTKN--TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNE 234 E + + +N F+ + LG+G + V + TGK YA K L+K+ I K K E Sbjct: 257 EMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIE 316 Query: 235 KQILEKVNSQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 K L +++++ V++L + ++ KD+L VL + G+L I EE + A Sbjct: 317 KHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYN--TLNEECTRHFGA 374 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV----------KIPEGDLIR 343 +IL ++ +H ++RDLKPENILLDD I+I+D G A + P + Sbjct: 375 QILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAK 434 Query: 344 GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 VGT Y++PE+L N+ G D W GC+IY+MI G+ PF+ E + +++ + Sbjct: 435 SFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYL----TFQKITK 490 Query: 404 TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGML-D 462 + +S F + + K +L +R E+++H FF++++FK ++ L D Sbjct: 491 LQFAFSAGFPTIIRDLIKKILVLQPSRRATI-----PEIQKHYFFQSVDFKDFDSIWLSD 545 Query: 463 PPFVPDPRAVYCKDVLDIEQFS 484 PP + P + K ++ + + + Sbjct: 546 PPEI-GPYKMTAKSMMKVPELN 566 >3UTO-A nrPDB Length = 573 Score = 284 bits (726), Expect = 9e-77, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 122/295 (41%), Gaps = 20/295 (6%) Query: 162 LDSMFFDRFLQWKWLERQPVTK------NTFRQYRVLGKGGFGEVCACQVRATGKMYACK 215 D+ FD WK QPV + + + LG G FG V RATG +A K Sbjct: 132 YDNYVFD---IWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAK 188 Query: 216 RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275 + + E Q + + +VNL A+E + + ++ M+GG+L + Sbjct: 189 FV---MTPHESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKV 245 Query: 276 YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDY--GHIRISDLGLA 333 + N E+ A+ Y ++ GL +H N V+ DLKPENI+ +++ D GL Sbjct: 246 ADEHNK-MSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLT 304 Query: 334 VKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVK 393 + ++ GT + APEV + G D W +G L Y ++ G SPF G + Sbjct: 305 AHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDET 364 Query: 394 REEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 V ++ SE+ K + LL D R+ + HP+ Sbjct: 365 LRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIH-----QALEHPWL 414 >4LG4-A nrPDB Length = 299 Score = 283 bits (725), Expect = 1e-76, Method: Composition-based stats. Identities = 68/270 (25%), Positives = 115/270 (42%), Gaps = 13/270 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + F LG+G +G V + +G++ A K++ + E I+++ Sbjct: 9 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV-----ESDLQEIIKEISIMQQC 63 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +S +VV +Y L +V+ G + I + N E+ L GLE Sbjct: 64 DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLIEDEIATILKSTLKGLEY 122 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV-GTVGYMAPEVLNNQ 360 LH ++R++K NILL+ GH +++D G+A ++ + R V GT +MAPEV+ Sbjct: 123 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 182 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W LG EM EG+ P+ + +S++ Sbjct: 183 GYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI-PTNPPPTFRKPELWSDDFTDFV 241 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 K L K+ +QR A ++ +HPF +N Sbjct: 242 KKCLVKNPEQR-----ATATQLLQHPFIKN 266 >3UDB-A nrPDB Length = 317 Score = 283 bits (724), Expect = 2e-76, Method: Composition-based stats. Identities = 68/286 (23%), Positives = 116/286 (40%), Gaps = 20/286 (6%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + + +G G FG + + ++ A K +E+ K + E + Sbjct: 17 DSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG----EKIDENVKREIINHRSL 72 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +V T L +V+ +GG+L I N G F E+ A F+ +++ G+ Sbjct: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSY 130 Query: 302 LHRENTVYRDLKPENILLDDY--GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 H +RDLK EN LLD ++I+D G + + VGT Y+APEVL Sbjct: 131 AHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLK 190 Query: 360 QRYGLSP-DYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH--KFSEEA 416 + Y D W G +Y M+ G PF +E + R+L + S E Sbjct: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPEC 250 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLD 462 + + + D +R+ E++ H +F K L A +++ Sbjct: 251 RHLISRIFVADPAKRISI-----PEIRNHEWF----LKNLPADLMN 287 >2HAK-A nrPDB Length = 328 Score = 282 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 81/294 (27%), Positives = 142/294 (48%), Gaps = 18/294 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 9 DEQPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVR 66 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L LV+ +GG++ ++ G +E RA F +I+ Sbjct: 67 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 124 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 ++ H++ V+RDLK EN+LLD +I+I+D G + + G+ + G+ Y APE+ Sbjct: 125 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPEL 184 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 ++Y G D W LG ++Y ++ G PF G+ K RE RVL + S + Sbjct: 185 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRE----RVLRGKYRIPFYMSTD 240 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDP 469 +++ K LL + +R ++ + + E L P PDP Sbjct: 241 CENLLKKLLVLNPIKR-----GSLEQIMKDRWMN----VGHEEEELKPYTEPDP 285 >4CSV-A nrPDB Length = 275 Score = 282 bits (722), Expect = 3e-76, Method: Composition-based stats. Identities = 63/264 (23%), Positives = 112/264 (42%), Gaps = 12/264 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 ++ + ++ R LG G FGEV + R A K L++ + L E Q Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS----VEEFLQEAQ 59 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++K+ +V L + + ++ M+ G L ++ + + L AA++ Sbjct: 60 IMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVA 119 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGYMA 353 G+ L +N ++RDL N L+ + ++++D GLA I E D R G + + A Sbjct: 120 SGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINE-DEYTARAGAKFPIKWTA 178 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 PE ++ R+ + D W G L++E+ GQ P+ G E+V+R Sbjct: 179 PEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERG-YRMPR--PQGC 235 Query: 413 SEEAKSICKMLLTKDAKQRLGCQE 436 EE + K ++R E Sbjct: 236 PEEIYELMLQCWNKSPEERPTFAE 259 >3DB8-A nrPDB Length = 317 Score = 282 bits (722), Expect = 3e-76, Method: Composition-based stats. Identities = 73/272 (26%), Positives = 123/272 (45%), Gaps = 12/272 (4%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P T + + R LGKGGF + T +++A K + K + K + E I + Sbjct: 38 PRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHK 97 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +++ VV +E D + +VL I L + E A ++ + + G+ Sbjct: 98 SLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLEL--HKRRKAVTEPEARYFMRQTIQGV 155 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLN 358 + LH ++RDLK N+ L+D ++I D GLA KI +G+ + GT Y+APEVL Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLC 215 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + + D W LGC++Y ++ G+ PF E +E R+ + E + A + Sbjct: 216 KKGHSFEVDIWSLGCILYTLLVGKPPF----ETSCLKETYIRIKKNEYSVPRHINPVASA 271 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + + +L D R AE+ FF + Sbjct: 272 LIRRMLHADPTLR-----PSVAELLTDEFFTS 298 >1KOA-A nrPDB Length = 491 Score = 281 bits (719), Expect = 5e-76, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 122/295 (41%), Gaps = 20/295 (6%) Query: 162 LDSMFFDRFLQWKWLERQPVTK------NTFRQYRVLGKGGFGEVCACQVRATGKMYACK 215 D+ FD WK QPV + + + LG G FG V RATG +A K Sbjct: 26 YDNYVFD---IWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAK 82 Query: 216 RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275 + + E Q + + +VNL A+E + + ++ M+GG+L + Sbjct: 83 FV---MTPHESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKV 139 Query: 276 YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDY--GHIRISDLGLA 333 + N E+ A+ Y ++ GL +H N V+ DLKPENI+ +++ D GL Sbjct: 140 ADEHNK-MSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLT 198 Query: 334 VKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVK 393 + ++ GT + APEV + G D W +G L Y ++ G SPF G + Sbjct: 199 AHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDET 258 Query: 394 REEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 V ++ SE+ K + LL D R+ + HP+ Sbjct: 259 LRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIH-----QALEHPWL 308 >6FDY-U nrPDB Length = 276 Score = 281 bits (718), Expect = 8e-76, Method: Composition-based stats. Identities = 73/278 (26%), Positives = 127/278 (45%), Gaps = 15/278 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQ-VRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + F LG G + V + T ++ A K + KK + K E+ L E +IL+ + Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVEN-LLTEIEILKGIR 69 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +V L D + L++ GGDL I+ E+ A + ++ L+ L Sbjct: 70 HPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHT--RRILPEKVARVFMQQLASALQFL 127 Query: 303 HRENTVYRDLKPENILLD--DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 H N + DLKP+NILL + H++++D G A + D G+ YMAPE++ + Sbjct: 128 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 187 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 +Y D W +G ++YE + GQ PF R E++ R E S + + + Sbjct: 188 QYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKI-RSNRVIELPLRPLLSRDCRDLL 246 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEA 458 + LL +D +R+ Q+ A HP+ ++ + + + Sbjct: 247 QRLLERDPSRRISFQDFFA-----HPW---VDLEHMPS 276 >4B8L-A nrPDB Length = 286 Score = 280 bits (717), Expect = 9e-76, Method: Composition-based stats. Identities = 70/274 (25%), Positives = 123/274 (44%), Gaps = 12/274 (4%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 + ++ T + F R LGKG FG V + + + A K L K +++K E E Sbjct: 7 MPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREI 66 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 +I + ++ + + + + L+L G+L + G F+E+R+ + E+ Sbjct: 67 EIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGR--FDEQRSATFMEEL 124 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 L H ++RD+KPEN+L+ G ++I+D G +V P R GT+ Y+ PE Sbjct: 125 ADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRR-RTMCGTLDYLPPE 183 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 ++ + + D W G L YE + G PF + E RR++ + + S+ Sbjct: 184 MIEGKTHDEKVDLWCAGVLCYEFLVGMPPF----DSPSHTETHRRIVNVDLKFPPFLSDG 239 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 +K + LL QRL + V HP+ + Sbjct: 240 SKDLISKLLRYHPPQRLPLKG-----VMEHPWVK 268 >4B6L-A nrPDB Length = 281 Score = 280 bits (717), Expect = 1e-75, Method: Composition-based stats. Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 12/270 (4%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P + T+ + R+LGKGGF TG YA K + + R+ K LNE ++ Sbjct: 5 PRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHR 64 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + + +V ++ +E D + + L + + L HI+ + E +Y +IL GL Sbjct: 65 DLQHRHIVRFSHHFEDADNIYIFLELCSRKSLA-HIWKARH-TLLEPEVRYYLRQILSGL 122 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLN 358 + LH+ ++RDLK N + + +++ D GLA ++ P + GT Y+APEVL Sbjct: 123 KYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL 182 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 Q +G D W LGC++Y ++ G PF E +E R + + S A+ Sbjct: 183 RQGHGPEADVWSLGCVMYTLLCGSPPF----ETADLKETYRCIKQVHYTLPASLSLPARQ 238 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + +L + R ++ RH FF Sbjct: 239 LLAAILRASPRDRPSI-----DQILRHDFF 263 >6FD3-A nrPDB Length = 300 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 69/269 (25%), Positives = 120/269 (44%), Gaps = 13/269 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 K + ++ +G+G G V ATG+ A K++ ++++ + + +NE ++ + Sbjct: 20 PKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMREN 76 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + +VN +Y D L +V+ + GG L + +E + E L L+ Sbjct: 77 KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALDF 133 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNNQ 360 LH ++RD+K +NILL G ++++D G +I PE VGT +MAPEV+ + Sbjct: 134 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRK 193 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 YG D W LG + EM+EG+ P+ + E + S + Sbjct: 194 AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERLSAVFRDFL 252 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 L D +R A E+ +HPF + Sbjct: 253 NRCLEMDVDRR-----GSAKELLQHPFLK 276 >6AO5-A nrPDB Length = 362 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 68/270 (25%), Positives = 115/270 (42%), Gaps = 13/270 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + F LG+G +G V + +G++ A K++ + E I+++ Sbjct: 8 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV-----ESDLQEIIKEISIMQQC 62 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +S +VV +Y L +V+ G + I + N E+ L GLE Sbjct: 63 DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLIEDEIATILKSTLKGLEY 121 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV-GTVGYMAPEVLNNQ 360 LH ++R++K NILL+ GH +++D G+A ++ + R V GT +MAPEV+ Sbjct: 122 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 181 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W LG EM EG+ P+ + +S++ Sbjct: 182 GYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI-PTNPPPTFRKPELWSDDFTDFV 240 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 K L K+ +QR A ++ +HPF +N Sbjct: 241 KKCLVKNPEQR-----ATATQLLQHPFIKN 265 >6C9D-A nrPDB Length = 459 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 81/294 (27%), Positives = 142/294 (48%), Gaps = 18/294 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 15 DEQPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVR 72 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 I++ +N +V L ET+ L LV+ +GG++ ++ G +E RA F +I+ Sbjct: 73 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 130 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 ++ H++ V+RDLK EN+LLD +I+I+D G + + G+ + G+ Y APE+ Sbjct: 131 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPEL 190 Query: 357 LNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 ++Y G D W LG ++Y ++ G PF G+ K RE RVL + S + Sbjct: 191 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRE----RVLRGKYRIPFYMSTD 246 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDP 469 +++ K LL + +R ++ + + E L P PDP Sbjct: 247 CENLLKKLLVLNPIKR-----GSLEQIMKDRWMN----VGHEEEELKPYTEPDP 291 >2UV2-A nrPDB Length = 325 Score = 277 bits (709), Expect = 9e-75, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 16/292 (5%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F Q++ + R ++ + LG G FG+V Q + T + A K ++ Sbjct: 16 ENLYFQSMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID---T 72 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 K + + E IL + +V L A+ ++ L +++ GG + + + P Sbjct: 73 KSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERP- 131 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DL 341 E + + L L LH ++RDLK NIL G I+++D G++ K Sbjct: 132 LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQR 191 Query: 342 IRGRVGTVGYMAPEVLN-----NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE 396 +GT +MAPEV+ ++ Y D W LG + EM E + P + Sbjct: 192 RDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLK 251 Query: 397 VDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + + T ++S K K L K+ R +++ +HPF Sbjct: 252 IAKSEPPT-LAQPSRWSSNFKDFLKKCLEKNVDAR-----WTTSQLLQHPFV 297 >4NIF-A nrPDB Length = 333 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 85/291 (29%), Positives = 128/291 (43%), Gaps = 27/291 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL-E 239 V + + +G G + E C +AT YA K ++K + + E +IL Sbjct: 5 VFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-------EIEILLR 57 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 ++ L Y+ + LV +M GG+L I + F E A F I + Sbjct: 58 YGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKI--LRQKFFSEREASFVLHTIGKTV 115 Query: 300 EDLHRENTVYRDLKPENIL-LDDYGH---IRISDLGLAVKI-PEGDLIRGRVGTVGYMAP 354 E LH + V+RDLKP NIL +D+ G+ +RI D G A ++ E L+ T ++AP Sbjct: 116 EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAP 175 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY----SH 410 EVL Q Y D W LG L+Y M+ G +PF EE+ R+ + + Sbjct: 176 EVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWN 234 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGML 461 SE AK + +L D QRL A +V +HP+ + +L L Sbjct: 235 TVSETAKDLVSKMLHVDPHQRLT-----AKQVLQHPWVTQKD--KLPQSQL 278 >4JG6-A nrPDB Length = 355 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 80/288 (27%), Positives = 126/288 (43%), Gaps = 25/288 (8%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL-EKVN 242 + + +G G + C +AT +A K ++K + + E +IL Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-------EIEILLRYGQ 87 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 ++ L Y+ + +V +M GG+L I + F E A I +E L Sbjct: 88 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKI--LRQKFFSEREASAVLFTITKTVEYL 145 Query: 303 HRENTVYRDLKPENIL-LDDYGH---IRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVL 357 H + V+RDLKP NIL +D+ G+ IRI D G A ++ E L+ T ++APEVL Sbjct: 146 HAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 205 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPF---RGRKEKVKREEVDRRVLETEEVYSHKFSE 414 Q Y + D W LG L+Y M+ G +PF + + Y + S+ Sbjct: 206 ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSD 265 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLD 462 AK + +L D QRL AA V RHP+ +++ +L L+ Sbjct: 266 TAKDLVSKMLHVDPHQRLT-----AALVLRHPWI--VHWDQLPQYQLN 306 >3NIZ-A nrPDB Length = 311 Score = 276 bits (706), Expect = 2e-74, Method: Composition-based stats. Identities = 67/318 (21%), Positives = 136/318 (42%), Gaps = 49/318 (15%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F +++ +G+G +G V + + G++ A KR+ Sbjct: 12 ENLYFQGL------------MEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDA- 57 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 + S A+ E +L++++ +V+L ++ L LV M DLK + G Sbjct: 58 EDEGIPSTAIREISLLKELHHPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKT-G 115 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDL 341 ++ + Y ++L G+ H+ ++RDLKP+N+L++ G ++++D GLA Sbjct: 116 LQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRS 175 Query: 342 IRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR- 399 V T+ Y AP+VL ++Y S D W +GC+ EMI G+ F G + + ++ Sbjct: 176 YTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSI 235 Query: 400 ------------------RVLETEEVYSHKFS-------EEAKSICKMLLTKDAKQRLGC 434 + + +S +E + +L D +R+ Sbjct: 236 LGTPNPREWPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRIS- 294 Query: 435 QEEGAAEVKRHPFFRNMN 452 A + HP+F++++ Sbjct: 295 ----ARDAMNHPYFKDLD 308 >3IS5-A nrPDB Length = 285 Score = 276 bits (705), Expect = 3e-74, Method: Composition-based stats. Identities = 72/293 (24%), Positives = 126/293 (43%), Gaps = 25/293 (8%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F Q + F R LG G FG+V + R++G K + K R Sbjct: 12 ENLYF-----------QGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRS 60 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY--NMGN 280 + + A E ++L+ ++ ++ + +E + +V+ GG+L I Sbjct: 61 QVPMEQIEA--EIEVLKSLDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARG 118 Query: 281 PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKIP 337 E +++ L H ++ V++DLKPENIL D + I+I D GLA Sbjct: 119 KALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFK 178 Query: 338 EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEV 397 + GT YMAPEV + D W G ++Y ++ G PF G + +++ Sbjct: 179 SDEHSTNAAGTALYMAPEVFK-RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKA 237 Query: 398 DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + V + +A + K +LTKD ++R AA+V H +F+ Sbjct: 238 TYKEPNYA-VECRPLTPQAVDLLKQMLTKDPERR-----PSAAQVLHHEWFKQ 284 >4I6B-A nrPDB Length = 308 Score = 275 bits (704), Expect = 3e-74, Method: Composition-based stats. Identities = 70/272 (25%), Positives = 122/272 (44%), Gaps = 12/272 (4%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P T + + + LGKGGF + K+YA K + R+ K E ++ Sbjct: 24 PTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHR 83 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 ++ + VV + +E K+ + ++L + + + E +Y +I+ GL Sbjct: 84 ILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILK--ARKVLTEPEVRYYLRQIVSGL 141 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE-GDLIRGRVGTVGYMAPEVLN 358 + LH + ++RDLK N +++ +++ D GLA ++ R GT Y++PEVLN Sbjct: 142 KYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN 201 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 Q +G D W LGC++Y M+ G+ PF E +E R + E AK Sbjct: 202 KQGHGAESDIWALGCVMYTMLLGRPPF----ETTNLKETYRSIREARYTMPSSLLAPAKH 257 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + +L+K+ + R ++ RH FF Sbjct: 258 LIASMLSKNPEDR-----PSLDDIIRHDFFTQ 284 >4CQG-A nrPDB Length = 331 Score = 274 bits (702), Expect = 5e-74, Method: Composition-based stats. Identities = 69/277 (24%), Positives = 121/277 (43%), Gaps = 18/277 (6%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 ++ + Y +G GGF +V TG+M A K ++K + E Sbjct: 1 MKDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEI 58 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 L+ + Q + L + ETK+ + +VL GG+L +I + EE +I Sbjct: 59 DALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQI 116 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR---VGTVGYM 352 L + +H + +RDLKPEN+L D+ +++ D GL K P+G+ G++ Y Sbjct: 117 LSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAK-PKGNKDYHLQECCGSLAYA 175 Query: 353 APEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 APE++ + Y G D W +G L+Y ++ G PF +++ R E Sbjct: 176 APELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEV----PKW 231 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 S + + + +L D K+R+ + + HP+ Sbjct: 232 LSPSSILLLQQMLQVDPKKRISMRN-----LLNHPWV 263 >6CMJ-A nrPDB Length = 321 Score = 274 bits (700), Expect = 8e-74, Method: Composition-based stats. Identities = 79/314 (25%), Positives = 141/314 (44%), Gaps = 24/314 (7%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKR- 221 ++++F + V + + +GKG +G V YA K L KK+ Sbjct: 13 ENLYFQGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKL 72 Query: 222 -------IKKRKGESMALNEKQILEKVNSQFVVNLAYAYET--KDALCLVLTIMNGGDLK 272 I+ R E IL+K++ VV L + +D L +V ++N G + Sbjct: 73 IRQAGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM 132 Query: 273 FHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGL 332 E++A FY +++ G+E LH + ++RD+KP N+L+ + GHI+I+D G+ Sbjct: 133 EV---PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGV 189 Query: 333 AVKIPEGD-LIRGRVGTVGYMAPEVLNNQR---YGLSPDYWGLGCLIYEMIEGQSPFRGR 388 + + D L+ VGT +MAPE L+ R G + D W +G +Y + GQ PF Sbjct: 190 SNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE 249 Query: 389 KEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + ++ + LE + +E+ K + +L K+ + R+ E+K HP+ Sbjct: 250 RIMCLHSKIKSQALEFPDQ--PDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPWV 302 Query: 449 RNMNFKRLEAGMLD 462 + L + + Sbjct: 303 TRHGAEPLPSEDEN 316 >4AF3-A nrPDB Length = 292 Score = 274 bits (700), Expect = 9e-74, Method: Composition-based stats. Identities = 73/286 (25%), Positives = 127/286 (44%), Gaps = 18/286 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + T + F R LGKG FG V + + + + A K L K +I+K E E +I Sbjct: 18 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 77 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 ++ ++ L + + + L+L G+L + F+E+R E+ Sbjct: 78 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSC--TFDEQRTATIMEELADA 135 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN 358 L H + ++RD+KPEN+LL G ++I+D G +V P + GT+ Y+ PE++ Sbjct: 136 LMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRR-KTMCGTLDYLPPEMIE 194 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 + + D W +G L YE++ G PF E E RR+++ + + A+ Sbjct: 195 GRMHNEKVDLWCIGVLCYELLVGNPPF----ESASHNETYRRIVKVDLKFPASVPTGAQD 250 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPP 464 + LL + +RL + A HP+ R + + PP Sbjct: 251 LISKLLRHNPSERLPLAQVSA-----HPWVRA------NSRRVLPP 285 >4AGU-A nrPDB Length = 311 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 71/311 (22%), Positives = 127/311 (40%), Gaps = 37/311 (11%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + + +G+G +G V C+ R TG++ A K+ + + +AL E ++L+++ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESE-DDPVIKKIALREIRMLKQLK 60 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +VNL + K L LV + L + G E + L + Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHEL--DRYQRGVPEHLVKSITWQTLQAVNFC 118 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNN-Q 360 H+ N ++RD+KPENIL+ + I++ D G A + D V T Y +PE+L Sbjct: 119 HKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR--------------------- 399 +YG D W +GC+ E++ G + G+ + + + + Sbjct: 179 QYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSG 238 Query: 400 -RVLETEEVYS-----HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNF 453 ++ + E++ S A + K L D +RL C ++ HP+F N+ Sbjct: 239 VKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTC-----EQLLHHPYFENIRE 293 Query: 454 KRLEAGMLDPP 464 A D P Sbjct: 294 IEDLAKEHDKP 304 >4D2V-A nrPDB Length = 356 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 122/284 (42%), Gaps = 17/284 (5%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN 233 ++ + + +G GGF +V TG+M A K ++K + Sbjct: 19 SHMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKT 76 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 E + L+ + Q + L + ET + + +VL GG+L +I + EE Sbjct: 77 EIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFR 134 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD--LIRGRVGTVGY 351 +I+ + +H + +RDLKPEN+L D+Y +++ D GL K ++ G + Y Sbjct: 135 QIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAY 194 Query: 352 MAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 APE++ + Y G D W +G L+Y ++ G PF ++ R + Sbjct: 195 AAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDV----PK 250 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF-RNMNF 453 S + + + +L D K+R+ + + HP+ ++ N+ Sbjct: 251 WLSPSSILLLQQMLQVDPKKRISMKN-----LLNHPWIMQDYNY 289 >2F57-A nrPDB Length = 317 Score = 272 bits (697), Expect = 2e-73, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 134/297 (45%), Gaps = 22/297 (7%) Query: 163 DSMFFDRFLQWKWLE----RQPV-----TKNTFRQYRVLGKGGFGEVCACQVRATGKMYA 213 ++++F + + Q V + + +G+G G VC + TGK A Sbjct: 15 ENLYFQSMSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVA 74 Query: 214 CKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKF 273 K+++ ++K++ + NE I+ + VV++ +Y D L +V+ + GG L Sbjct: 75 VKKMD---LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTD 131 Query: 274 HIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA 333 + + EE+ +L L LH + ++RD+K ++ILL G I++SD G Sbjct: 132 IVTHTR---MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFC 188 Query: 334 VKIP-EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV 392 ++ E + VGT +MAPEV++ YG D W LG ++ EMI+G+ P+ Sbjct: 189 AQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQ 248 Query: 393 KREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 + R L HK S + ++L ++ QR A E+ HPF + Sbjct: 249 AMRRI-RDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQR-----ATAQELLGHPFLK 299 >3Q53-A nrPDB Length = 306 Score = 272 bits (696), Expect = 3e-73, Method: Composition-based stats. Identities = 70/269 (26%), Positives = 120/269 (44%), Gaps = 13/269 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 K + ++ +G+G G V ATG+ A +++ ++++ + + +NE ++ + Sbjct: 19 PKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN---LQQQPKKELIINEILVMREN 75 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + +VN +Y D L +V+ + GG L + +E + E L LE Sbjct: 76 KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALEF 132 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNNQ 360 LH ++RD+K +NILL G ++++D G +I PE VGT +MAPEV+ + Sbjct: 133 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRK 192 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 YG D W LG + EMIEG+ P+ + E K S + Sbjct: 193 AYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI-ATNGTPELQNPEKLSAIFRDFL 251 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 L D ++R A E+ +H F + Sbjct: 252 NRCLEMDVEKR-----GSAKELIQHQFLK 275 >3LM0-A nrPDB Length = 327 Score = 272 bits (695), Expect = 4e-73, Method: Composition-based stats. Identities = 82/302 (27%), Positives = 136/302 (45%), Gaps = 22/302 (7%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQY--RVLGKGGFGEVCACQVRATGKMYACKRLEKK 220 ++++F + N F + LG+G F V C ++TG+ YA K L+K+ Sbjct: 16 ENLYFQSMENF----------NNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKR 65 Query: 221 RIKKRKGESMALNEKQILEKVNS-QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG 279 R + + + L+E +LE S V+NL YE + L+L GG++ Sbjct: 66 R-RGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPEL 124 Query: 280 NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKI 336 E + +IL G+ LH+ N V+ DLKP+NILL G I+I D G++ KI Sbjct: 125 AEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI 184 Query: 337 PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE 396 +R +GT Y+APE+LN + D W +G + Y ++ SPF G + Sbjct: 185 GHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLN 244 Query: 397 VDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRL 456 + + ++ E S+ A + LL K+ ++R A H + + +F+ L Sbjct: 245 ISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKR-----PTAEICLSHSWLQQWDFENL 299 Query: 457 EA 458 Sbjct: 300 FH 301 >6GU6-A nrPDB Length = 302 Score = 271 bits (694), Expect = 5e-73, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 123/299 (41%), Gaps = 35/299 (11%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + + +G+G +G V + + TG++ A K++ + ++ S A+ E +L+++ Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKEL 63 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN-PGFEEERALFYAAEILCGLE 300 +V+L L L+ ++ DLK ++ ++ + Y +IL G+ Sbjct: 64 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNN 359 H ++RDLKP+N+L+DD G I+++D GLA + V T+ Y +PEVL Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 182 Query: 360 Q-RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKF------ 412 RY D W +G + E+ + F G E + + R + + Sbjct: 183 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 242 Query: 413 -------------------SEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 E + +L D +R+ + HP+F +++ Sbjct: 243 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM-----ALNHPYFNDLD 296 >4KS7-A nrPDB Length = 292 Score = 271 bits (694), Expect = 5e-73, Method: Composition-based stats. Identities = 69/268 (25%), Positives = 125/268 (46%), Gaps = 13/268 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + Y +G+G G VC + + +G+ A K ++ ++K++ + NE I+ Sbjct: 21 PRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMD---LRKQQRRELLFNEVVIMRDY 77 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 VV + +Y + L +++ + GG L + + EE+ +L L Sbjct: 78 QHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVR---LNEEQIATVCEAVLQALAY 134 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRVGTVGYMAPEVLNNQ 360 LH + ++RD+K ++ILL G +++SD G +I + R VGT +MAPEV++ Sbjct: 135 LHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS 194 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W LG ++ EM++G+ P+ V+ + R + SHK S + Sbjct: 195 LYATEVDIWSLGIMVIEMVDGEPPYF-SDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFL 253 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + +L +D ++R A E+ HPF Sbjct: 254 ERMLVRDPQER-----ATAQELLDHPFL 276 >3FXW-A nrPDB Length = 336 Score = 271 bits (693), Expect = 7e-73, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 126/298 (42%), Gaps = 24/298 (8%) Query: 164 SMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIK 223 S + Q ++ VT + +VLG G G+V C R TG+ A K L Sbjct: 9 SSGLEVLFQGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKA 68 Query: 224 KRKGESMALNEKQILEKVNSQFVVNLAYAYET----KDALCLVLTIMNGGDLKFHIYNMG 279 +++ + + +V + YE K L +++ M GG+L I G Sbjct: 69 RQEVDHHW-------QASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERG 121 Query: 280 NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKI 336 + F E A +I ++ LH N +RD+KPEN+L ++++D G A + Sbjct: 122 DQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKET 181 Query: 337 PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE 396 + ++ T Y+APEVL ++Y S D W LG ++Y ++ G PF + Sbjct: 182 TQN-ALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPG 240 Query: 397 VDRRV----LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + RR+ + SE+AK + ++LL D +RL + HP+ Sbjct: 241 MKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTI-----TQFMNHPWINQ 293 >2OU7-A nrPDB Length = 335 Score = 270 bits (691), Expect = 1e-72, Method: Composition-based stats. Identities = 76/305 (24%), Positives = 130/305 (42%), Gaps = 28/305 (9%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LGKGGF + T +++A K + K + K E I + Q VV Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 +E D + +VL + L + E A +Y +I+ G + LHR ++RD Sbjct: 109 FFEDNDFVFVVLELCRRRSLLEL--HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 166 Query: 312 LKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG 370 LK N+ L++ ++I D GLA K+ +G+ + GT Y+APEVL+ + + D W Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWS 226 Query: 371 LGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ 430 +GC++Y ++ G+ PF E +E R+ + E + A S+ + +L D Sbjct: 227 IGCIMYTLLVGKPPF----ETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA 282 Query: 431 RLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVN 490 R E+ FF + ++P + C L I ++ + Sbjct: 283 RPTIN-----ELLNDEFFTS-------------GYIPARLPITC---LTIPPRFSIAPSS 321 Query: 491 LDHTD 495 LD ++ Sbjct: 322 LDPSN 326 >4J52-A nrPDB Length = 293 Score = 270 bits (691), Expect = 1e-72, Method: Composition-based stats. Identities = 70/260 (26%), Positives = 116/260 (44%), Gaps = 12/260 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LGKGGF + T +++A K + K + K E I + Q VV Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 +E D + +VL + L + E A +Y +I+ G + LHR ++RD Sbjct: 82 FFEDNDFVFVVLELCRRRSLLEL--HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 139 Query: 312 LKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWG 370 LK N+ L++ ++I D GLA K+ +G+ + GT Y+APEVL+ + + D W Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWS 199 Query: 371 LGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ 430 +GC++Y ++ G+ PF E +E R+ + E + A S+ + +L D Sbjct: 200 IGCIMYTLLVGKPPF----ETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA 255 Query: 431 RLGCQEEGAAEVKRHPFFRN 450 R E+ FF + Sbjct: 256 RPTIN-----ELLNDEFFTS 270 >2Q0N-A nrPDB Length = 301 Score = 270 bits (690), Expect = 2e-72, Method: Composition-based stats. Identities = 76/268 (28%), Positives = 131/268 (48%), Gaps = 13/268 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ + +G+G G VC VR++GK+ A K+++ ++K++ + NE I+ Sbjct: 27 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDY 83 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + VV + +Y D L +V+ + GG L + + EE+ +L L Sbjct: 84 QHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSV 140 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQ 360 LH + ++RD+K ++ILL G +++SD G ++ E + VGT +MAPE+++ Sbjct: 141 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 200 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 YG D W LG ++ EM++G+ P+ +K ++ R L HK S K Sbjct: 201 PYGPEVDIWSLGIMVIEMVDGEPPYFNE-PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL 259 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 LL +D QR AAE+ +HPF Sbjct: 260 DRLLVRDPAQR-----ATAAELLKHPFL 282 >4QMW-A nrPDB Length = 310 Score = 269 bits (689), Expect = 2e-72, Method: Composition-based stats. Identities = 65/268 (24%), Positives = 114/268 (42%), Gaps = 14/268 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + F + +GKG FGEV T K+ A K ++ + + + E +L + Sbjct: 27 PEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQC 84 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +S +V +Y L +++ + GG + +E + EIL GL+ Sbjct: 85 DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE---PGPLDETQIATILREILKGLDY 141 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRVGTVGYMAPEVLNNQ 360 LH E ++RD+K N+LL ++G ++++D G+A ++ + + R VGT +MAPEV+ Sbjct: 142 LHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS 201 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W LG E+ G+ P + + +S+ K Sbjct: 202 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPK---NNPPTLEGNYSKPLKEFV 258 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + L K+ R A E+ +H F Sbjct: 259 EACLNKEPSFR-----PTAKELLKHKFI 281 >4JDH-A nrPDB Length = 346 Score = 269 bits (689), Expect = 2e-72, Method: Composition-based stats. Identities = 76/268 (28%), Positives = 131/268 (48%), Gaps = 13/268 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ + +G+G G VC VR++GK+ A K+++ ++K++ + NE I+ Sbjct: 72 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDY 128 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + VV + +Y D L +V+ + GG L + + EE+ +L L Sbjct: 129 QHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSV 185 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQ 360 LH + ++RD+K ++ILL G +++SD G ++ E + VGT +MAPE+++ Sbjct: 186 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 245 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 YG D W LG ++ EM++G+ P+ +K ++ R L HK S K Sbjct: 246 PYGPEVDIWSLGIMVIEMVDGEPPYFNE-PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL 304 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 LL +D QR AAE+ +HPF Sbjct: 305 DRLLVRDPAQR-----ATAAELLKHPFL 327 >6HXF-B nrPDB Length = 302 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 127/296 (42%), Gaps = 16/296 (5%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231 +++ + R + LG G FG+V + + TG + A K +E K + Sbjct: 7 EYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDY 63 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 + E +IL + ++V L AY L +++ GG + + + + G E + Sbjct: 64 IVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLEL-DRGLTEPQIQVV 122 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGL-AVKIPEGDLIRGRVGTVG 350 ++L L LH + ++RDLK N+L+ G IR++D G+ A + +GT Sbjct: 123 CRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPY 182 Query: 351 YMAPEVLN-----NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE 405 +MAPEV+ + Y D W LG + EM + + P ++ + T Sbjct: 183 WMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPT- 241 Query: 406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGML 461 + K+S E + K+ L K+ + R AA++ HPF ++ + ++ Sbjct: 242 LLTPSKWSVEFRDFLKIALDKNPETR-----PSAAQLLEHPFVSSITSNKALRELV 292 >4KRC-A nrPDB Length = 317 Score = 269 bits (688), Expect = 3e-72, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 120/300 (40%), Gaps = 44/300 (14%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F+Q LG G + V + TG A K ++ + S A+ E +++++ + Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELKHE 63 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG----NPGFEEERALFYAAEILCGLE 300 +V L T++ L LV M+ DLK ++ + G E ++ ++L GL Sbjct: 64 NIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNN 359 H ++RDLKP+N+L++ G +++ D GLA + V T+ Y AP+VL Sbjct: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 Query: 360 QR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE---- 414 R Y S D W GC++ EMI G+ F G ++ + + + + E ++ Sbjct: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 Query: 415 --------------------------EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 LL + RL A + HP+F Sbjct: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS-----AKQALHHPWF 297 >4XBR-A nrPDB Length = 366 Score = 269 bits (687), Expect = 3e-72, Method: Composition-based stats. Identities = 76/268 (28%), Positives = 131/268 (48%), Gaps = 13/268 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ + +G+G G VC VR++GK+ A K+++ ++K++ + NE I+ Sbjct: 92 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDY 148 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + VV + +Y D L +V+ + GG L + + EE+ +L L Sbjct: 149 QHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSV 205 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQ 360 LH + ++RD+K ++ILL G +++SD G ++ E + VGT +MAPE+++ Sbjct: 206 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 265 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 YG D W LG ++ EM++G+ P+ +K ++ R L HK S K Sbjct: 266 PYGPEVDIWSLGIMVIEMVDGEPPYFNE-PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL 324 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 LL +D QR AAE+ +HPF Sbjct: 325 DRLLVRDPAQR-----ATAAELLKHPFL 347 >1NY3-A nrPDB Length = 400 Score = 269 bits (687), Expect = 3e-72, Method: Composition-based stats. Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 26/284 (9%) Query: 178 RQPVTKNTFRQY-RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 ++ + ++ +VLG G G+V + T + +A K L+ A E + Sbjct: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVE 106 Query: 237 ILEKV-NSQFVVNLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 + + +V + YE + L +V+ ++GG+L I + G+ F E A Sbjct: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGT 348 I ++ LH N +RD+KPEN+L ++++D G A + + + T Sbjct: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV----LET 404 Y+APEVL ++Y S D W LG ++Y ++ G PF + R+ E Sbjct: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 Query: 405 EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + SEE K + + LL + QR+ E HP+ Sbjct: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI 325 >2OZA-A nrPDB Length = 356 Score = 268 bits (686), Expect = 4e-72, Method: Composition-based stats. Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 26/284 (9%) Query: 178 RQPVTKNTFRQY-RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 ++ + ++ +VLG G G+V + T + +A K L+ A E + Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVE 62 Query: 237 ILEKV-NSQFVVNLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 + + +V + YE + L +V+ ++GG+L I + G+ F E A Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGT 348 I ++ LH N +RD+KPEN+L ++++D G A + + + T Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 182 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV----LET 404 Y+APEVL ++Y S D W LG ++Y ++ G PF + R+ E Sbjct: 183 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 242 Query: 405 EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + SEE K + + LL + QR+ E HP+ Sbjct: 243 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI 281 >3KA0-A nrPDB Length = 320 Score = 268 bits (685), Expect = 5e-72, Method: Composition-based stats. Identities = 69/284 (24%), Positives = 120/284 (42%), Gaps = 26/284 (9%) Query: 178 RQPVTKNTFRQY-RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 ++ + ++ +VLG G G+V + T + +A K L+ A E + Sbjct: 9 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVE 60 Query: 237 ILEKV-NSQFVVNLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 + + +V + YE + L +V+ ++GG+L I + G+ F E A Sbjct: 61 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 120 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGT 348 I ++ LH N +RD+KPEN+L ++++D G A + + + T Sbjct: 121 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYT 180 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV----LET 404 Y+APEVL ++Y S D W LG ++Y ++ G PF + R+ E Sbjct: 181 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 240 Query: 405 EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + SEE K + + LL + QR+ E HP+ Sbjct: 241 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI 279 >3DAK-A nrPDB Length = 290 Score = 268 bits (685), Expect = 6e-72, Method: Composition-based stats. Identities = 73/291 (25%), Positives = 129/291 (44%), Gaps = 26/291 (8%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + ++ + V+G G V A + A KR+ ++ + E L E Q + Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDE--LLKEIQAM 62 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY------NMGNPGFEEERALFYA 292 + + +V+ ++ KD L LV+ +++GG + I + +E Sbjct: 63 SQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATIL 122 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV------KIPEGDLIRGRV 346 E+L GLE LH+ ++RD+K NILL + G ++I+D G++ I + + V Sbjct: 123 REVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFV 182 Query: 347 GTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSP---FRGRKEKVKREEVDRRVL 402 GT +MAPEV+ + Y D W G E+ G +P + K + + D L Sbjct: 183 GTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSL 242 Query: 403 ET---EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 ET ++ K+ + + + + L KD ++R AAE+ RH FF+ Sbjct: 243 ETGVQDKEMLKKYGKSFRKMISLCLQKDPEKR-----PTAAELLRHKFFQK 288 >4FIE-A nrPDB Length = 423 Score = 268 bits (685), Expect = 6e-72, Method: Composition-based stats. Identities = 76/268 (28%), Positives = 131/268 (48%), Gaps = 13/268 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ + +G+G G VC VR++GK+ A K+++ ++K++ + NE I+ Sbjct: 149 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDY 205 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + VV + +Y D L +V+ + GG L + + EE+ +L L Sbjct: 206 QHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSV 262 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQ 360 LH + ++RD+K ++ILL G +++SD G ++ E + VGT +MAPE+++ Sbjct: 263 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 322 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 YG D W LG ++ EM++G+ P+ +K ++ R L HK S K Sbjct: 323 PYGPEVDIWSLGIMVIEMVDGEPPYFNE-PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL 381 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 LL +D QR AAE+ +HPF Sbjct: 382 DRLLVRDPAQR-----ATAAELLKHPFL 404 >5D7A-A nrPDB Length = 308 Score = 267 bits (683), Expect = 9e-72, Method: Composition-based stats. Identities = 68/278 (24%), Positives = 117/278 (42%), Gaps = 24/278 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ- 244 F ++G G +G+V + TG++ A K ++ E E +L+K + Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG----DEEEEIKQEINMLKKYSHHR 74 Query: 245 FVVNLAYAYETKDA------LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + A+ K+ L LV+ G + I N +EE + EIL G Sbjct: 75 NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 134 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRVGTVGYMAPEVL 357 L LH+ ++RD+K +N+LL + +++ D G++ ++ +GT +MAPEV+ Sbjct: 135 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 194 Query: 358 N-----NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 + Y D W LG EM EG P + R + S K+ Sbjct: 195 ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSKKW 252 Query: 413 SEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 S++ +S + L K+ QR ++ +HPF R+ Sbjct: 253 SKKFQSFIESCLVKNHSQR-----PATEQLMKHPFIRD 285 >2WQN-A nrPDB Length = 310 Score = 267 bits (683), Expect = 9e-72, Method: Composition-based stats. Identities = 67/251 (26%), Positives = 112/251 (44%), Gaps = 3/251 (1%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 FR + +G+G F EV G A K+++ + K + + E +L+++N Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG--FEEERALFYAAEILCGLEDL 302 V+ ++ + L +VL + + GDL I + E Y ++ LE + Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE-GDLIRGRVGTVGYMAPEVLNNQR 361 H ++RD+KP N+ + G +++ DLGL VGT YM+PE ++ Sbjct: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 Y D W LGCL+YEM QSPF G K + + + S +SEE + + Sbjct: 213 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVN 272 Query: 422 MLLTKDAKQRL 432 M + D ++R Sbjct: 273 MCINPDPEKRP 283 >3KN6-A nrPDB Length = 325 Score = 267 bits (683), Expect = 1e-71, Method: Composition-based stats. Identities = 72/267 (26%), Positives = 118/267 (44%), Gaps = 20/267 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-NSQFVVN 248 + LG+G F C + + + +A K + K+ E+ E L+ +V Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 70 Query: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV 308 L + + LV+ ++NGG+L I + F E A + +++ + +H V Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKKKKH--FSETEASYIMRKLVSAVSHMHDVGVV 128 Query: 309 YRDLKPENILL---DDYGHIRISDLGLAV-KIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 +RDLKPEN+L +D I+I D G A K P+ ++ T+ Y APE+LN Y Sbjct: 129 HRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDE 188 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEK-------VKREEVDRRVLETEEVYSHKFSEEAK 417 S D W LG ++Y M+ GQ PF+ +++ + E S+EAK Sbjct: 189 SCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAK 248 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEVKR 444 + + LLT D +RL E + Sbjct: 249 DLIQGLLTVDPNKRLKMSGLRYNEWLQ 275 >5YV8-A nrPDB Length = 298 Score = 267 bits (683), Expect = 1e-71, Method: Composition-based stats. Identities = 78/297 (26%), Positives = 131/297 (44%), Gaps = 39/297 (13%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKR------------------- 221 V N + +GKG +G V YA K L KK+ Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 222 ----IKKRKGESMALNEKQILEKVNSQFVVNLAYAYET--KDALCLVLTIMNGGDLKFHI 275 I+ R E IL+K++ VV L + +D L +V ++N G + Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV- 128 Query: 276 YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 E++A FY +++ G+E LH + ++RD+KP N+L+ + GHI+I+D G++ + Sbjct: 129 --PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE 186 Query: 336 IPEGD-LIRGRVGTVGYMAPEVLNNQR---YGLSPDYWGLGCLIYEMIEGQSPFRGRKEK 391 D L+ VGT +MAPE L+ R G + D W +G +Y + GQ PF + Sbjct: 187 FKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIM 246 Query: 392 VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 ++ + LE + +E+ K + +L K+ + R+ E+K HP+ Sbjct: 247 CLHSKIKSQALEFPDQ--PDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPWV 296 >4BBM-A nrPDB Length = 331 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 137/329 (41%), Gaps = 50/329 (15%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F + ++G+G +G V C+ + TG++ A K+ + Sbjct: 17 ENLYFQSM-------------EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESD- 62 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 + + +A+ E ++L+++ + +VNL + K LV ++ L + G Sbjct: 63 DDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDL--ELFPNG 120 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDL 341 + + Y +I+ G+ H N ++RD+KPENIL+ G +++ D G A + G++ Sbjct: 121 LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV 180 Query: 342 IRGRVGTVGYMAPEVLNNQ-RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR- 399 V T Y APE+L +YG + D W +GCL+ EM G+ F G + + + Sbjct: 181 YDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMC 240 Query: 400 ---------------------RVLETEEVYS-----HKFSEEAKSICKMLLTKDAKQRLG 433 R+ E +E K SE + K L D +R Sbjct: 241 LGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPF 300 Query: 434 CQEEGAAEVKRHPFFRNMNFKRLEAGMLD 462 C AE+ H FF+ F + L Sbjct: 301 C-----AELLHHDFFQMDGFAERFSQELQ 324 >4APC-A nrPDB Length = 350 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 119/273 (43%), Gaps = 18/273 (6%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F + + + +G+G FG+ + G+ Y K + R+ Sbjct: 16 ENLYFQSM-------------EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRM 62 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 ++ E E +L + +V ++E +L +V+ GGDL I Sbjct: 63 SSKEREES-RREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVL 121 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DL 341 F+E++ L + +I L+ +H ++RD+K +NI L G +++ D G+A + +L Sbjct: 122 FQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVEL 181 Query: 342 IRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV 401 R +GT Y++PE+ N+ Y D W LGC++YE+ + F K ++ Sbjct: 182 ARACIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGS 241 Query: 402 LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGC 434 S +S + +S+ L ++ + R Sbjct: 242 F---PPVSLHYSYDLRSLVSQLFKRNPRDRPSV 271 >5GRN-A nrPDB Length = 356 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 70/343 (20%), Positives = 117/343 (34%), Gaps = 55/343 (16%) Query: 134 LQKPCKELFSACAQSV----HEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQY 189 QKP E+ +S+ HEY+ +P DS R ++ Sbjct: 5 KQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDS-------------RWEFPRDGLVLG 51 Query: 190 RVLGKGGFGEVCACQVRATGK-----MYACKRLEKKRIKKRKGESMALNEKQILEKVN-S 243 RVLG G FG+V + A K L+ K ++E +I+ + Sbjct: 52 RVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEK--QALMSELKIMTHLGPH 109 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN----------------------- 280 +VNL A + ++ GDL +++ + Sbjct: 110 LNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDN 169 Query: 281 -PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG 339 G L + ++ G+E L +N V+RDL N+LL ++I D GLA I Sbjct: 170 SEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHD 229 Query: 340 DLIRGRVGT---VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKRE 395 + T V +MAPE + + Y D W G L++E+ G +P+ G Sbjct: 230 SNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFY 289 Query: 396 EVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEG 438 + + + E I + ++R Sbjct: 290 NKIKSGYRMAK--PDHATSEVYEIMVKCWNSEPEKRPSFYHLS 330 >2XYN-A nrPDB Length = 292 Score = 265 bits (678), Expect = 4e-71, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 114/288 (39%), Gaps = 19/288 (6%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F +W+ +ER +T LG G +GEV + A K L++ + Sbjct: 17 ENLYFQSMDKWE-MERTDITMKH-----KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM 70 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 + L E +++++ +V L + +V M G+L ++ Sbjct: 71 E----VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 126 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI 342 L+ A +I +E L ++N ++RDL N L+ + ++++D GL+ + GD Sbjct: 127 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTY 185 Query: 343 RGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVD 398 G + + APE L + + D W G L++E+ G SP+ G + ++ Sbjct: 186 TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLE 245 Query: 399 RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEE-GAAEVKRH 445 + E+ + + + R E A E H Sbjct: 246 KG-YRMEQ--PEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 290 >1G3N-A nrPDB Length = 326 Score = 264 bits (676), Expect = 6e-71, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 125/314 (39%), Gaps = 39/314 (12%) Query: 183 KNTFRQYRVLGKGGFGEVCACQV-RATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + +G+G +G+V + + G+ A KR+ + + + E +L + Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGE-EGMPLSTIREVAVLRHL 68 Query: 242 N---SQFVVNLAYAY-----ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 VV L + + L LV ++ DL ++ + PG E Sbjct: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMF 127 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMA 353 ++L GL+ LH V+RDLKP+NIL+ G I+++D GLA + V T+ Y A Sbjct: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV-LETEEVYSHKF 412 PEVL Y D W +GC+ EM + FRG + + ++ + L EE + Sbjct: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 413 --------SEEA--------------KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 S+ A K + LT + +R+ A HP+F++ Sbjct: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYFQD 302 Query: 451 MNFKRLEAGMLDPP 464 + + PP Sbjct: 303 LERCKENLDSHLPP 316 >5DBX-A nrPDB Length = 328 Score = 264 bits (676), Expect = 6e-71, Method: Composition-based stats. Identities = 76/291 (26%), Positives = 129/291 (44%), Gaps = 26/291 (8%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 P+ ++ + V+G G V A + + A KR+ ++ + E L E Q + Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDE--LLKEIQAM 63 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY------NMGNPGFEEERALFYA 292 + + VV ++ KD L LV+ +++GG + I N EE Sbjct: 64 SQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIL 123 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG------DLIRGRV 346 E+L GL+ LHR ++RDLK NILL + G ++I+D G++ + G + + V Sbjct: 124 KEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFV 183 Query: 347 GTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSP---FRGRKEKVKREEVDRRVL 402 GT +MAPEV+ + Y D W G E+ G +P + K + + D L Sbjct: 184 GTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTL 243 Query: 403 ET---EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 ET ++ K+ + + + + L KD +R AAE+ + FF+ Sbjct: 244 ETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKR-----PTAAELLKCKFFQK 289 >1CM8-A nrPDB Length = 367 Score = 264 bits (675), Expect = 8e-71, Method: Composition-based stats. Identities = 81/315 (25%), Positives = 137/315 (43%), Gaps = 52/315 (16%) Query: 178 RQPVTKN------TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231 RQ VTK +R + +G G +G VC+ TG A K+L + + A Sbjct: 13 RQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRA 71 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEE 285 E ++L+ + + V+ L + + L LV+ M G DL M + E Sbjct: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKL---MKHEKLGE 127 Query: 286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR 345 +R F ++L GL +H ++RDLKP N+ +++ ++I D GLA + + G Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGY 185 Query: 346 VGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 V T Y APEV+ N RY + D W +GC++ EMI G++ F+G + +E+ + Sbjct: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 Query: 405 EEVYSHKF---------------------------SEEAKSICKMLLTKDAKQRLGCQEE 437 + + S A ++ + +L DA+QR+ Sbjct: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT---- 301 Query: 438 GAAEVKRHPFFRNMN 452 A E HP+F +++ Sbjct: 302 -AGEALAHPYFESLH 315 >2XIK-A nrPDB Length = 294 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 65/268 (24%), Positives = 115/268 (42%), Gaps = 14/268 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + F + +GKG FGEV T ++ A K ++ + + + E +L + Sbjct: 17 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQC 74 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +S ++ +Y L +++ + GG + EE EIL GL+ Sbjct: 75 DSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK---PGPLEETYIATILREILKGLDY 131 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRVGTVGYMAPEVLNNQ 360 LH E ++RD+K N+LL + G ++++D G+A ++ + + R VGT +MAPEV+ Sbjct: 132 LHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS 191 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W LG E+ +G+ P + + + + S+ K Sbjct: 192 AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPK---NSPPTLEGQHSKPFKEFV 248 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + L KD + R A E+ +H F Sbjct: 249 EACLNKDPRFR-----PTAKELLKHKFI 271 >4FZF-B nrPDB Length = 283 Score = 263 bits (672), Expect = 2e-70, Method: Composition-based stats. Identities = 65/268 (24%), Positives = 113/268 (42%), Gaps = 14/268 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + F + +GKG FGEV T ++ A K ++ + + + E +L + Sbjct: 6 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQC 63 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +S +V +Y L +++ + GG + F+E + EIL GL+ Sbjct: 64 DSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA---GPFDEFQIATMLKEILKGLDY 120 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRVGTVGYMAPEVLNNQ 360 LH E ++RD+K N+LL + G ++++ G+A ++ + + R VGT +MAPEV+ Sbjct: 121 LHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS 180 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W LG E+ +G+ P + + F++ K Sbjct: 181 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPK---NNPPTLVGDFTKSFKEFI 237 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 L KD R A E+ +H F Sbjct: 238 DACLNKDPSFR-----PTAKELLKHKFI 260 >1V0B-A nrPDB Length = 288 Score = 262 bits (670), Expect = 3e-70, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 122/297 (41%), Gaps = 36/297 (12%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + +G+G +G V Q G+ +A K++ ++ + S + E IL+++ Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNN-YGETFALKKIRLEK-EDEGIPSTTIREISILKELK 58 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +V L TK L LV ++ DLK + ++ G E A + ++L G+ Sbjct: 59 HSNIVKLYDVIHTKKRLVLVFEHLD-QDLKKLL-DVCEGGLESVTAKSFLLQLLNGIAYC 116 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNN-Q 360 H ++RDLKP+N+L++ G ++I+D GLA V T+ Y AP+VL + Sbjct: 117 HDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSK 176 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK--- 417 +Y + D W +GC+ EM+ G F G E + + R + +E K Sbjct: 177 KYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDP 236 Query: 418 ----------------------SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 + +L D QR+ A + H +F+ N Sbjct: 237 NFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRIT-----AKQALEHAYFKENN 288 >3HKO-A nrPDB Length = 345 Score = 261 bits (668), Expect = 5e-70, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 131/338 (38%), Gaps = 61/338 (18%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F LE Q + +G+G +G V T + A K + K +I Sbjct: 12 ENLYFQGG---SLLELQ----KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKI 64 Query: 223 K--KRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY---- 276 + K E ++++K++ + L YE + +CLV+ + +GG L + Sbjct: 65 RQINPKDVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFID 124 Query: 277 -NMGNPGFE---------------------------------EERALFYAAEILCGLEDL 302 + G + E+ +I L L Sbjct: 125 DSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYL 184 Query: 303 HRENTVYRDLKPENILL--DDYGHIRISDLGLAV---KIPEGDLI--RGRVGTVGYMAPE 355 H + +RD+KPEN L + I++ D GL+ K+ G+ + GT ++APE Sbjct: 185 HNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPE 244 Query: 356 VLN--NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 VLN N+ YG D W G L++ ++ G PF G + +V + L E + S Sbjct: 245 VLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLS 304 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 A+ + LL ++ +R A +HP+ Sbjct: 305 PLARDLLSNLLNRNVDERF-----DAMRALQHPWISQF 337 >4WNO-A nrPDB Length = 287 Score = 261 bits (667), Expect = 6e-70, Method: Composition-based stats. Identities = 71/280 (25%), Positives = 127/280 (45%), Gaps = 20/280 (7%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATG-KMYACKRLEKKRIKKRKGESMALNEKQI 237 + V K F + ++G G F V + RA A K + KK + K +++ E +I Sbjct: 13 ETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKS--QTLLGKEIKI 70 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 L+++ + +V L E +++ LV+ NGGDL +++ M E+ + +I Sbjct: 71 LKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMR--TLSEDTIRLFLQQIAG 128 Query: 298 GLEDLHRENTVYRDLKPENILLDDYG---------HIRISDLGLAVKIPEGDLIRGRVGT 348 + LH + ++RDLKP+NILL + ++I+D G A + + G+ Sbjct: 129 AMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGS 188 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY 408 YMAPEV+ +Q Y D W +G ++Y+ + G++PF+ + R + Sbjct: 189 PMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRL-FYEKNKTLVPTI 247 Query: 409 SHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + S + + LL ++ K R+ E HPF Sbjct: 248 PRETSAPLRQLLLALLQRNHKDRM-----DFDEFFHHPFL 282 >4EWQ-A nrPDB Length = 383 Score = 261 bits (667), Expect = 6e-70, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 134/330 (40%), Gaps = 54/330 (16%) Query: 163 DSMFFDRFLQWKWLE--RQPVTK------NTFRQYRVLGKGGFGEVCACQVRATGKMYAC 214 ++++F + RQ + K ++ +G G +G VCA TG A Sbjct: 16 ENLYFQSNASQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAV 75 Query: 215 KRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAY------ETKDALCLVLTIMNG 268 K+L + + E ++L+ + + V+ L + E + + LV +M G Sbjct: 76 KKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-G 133 Query: 269 GDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRIS 328 DL + ++ F +IL GL+ +H + ++RDLKP N+ +++ ++I Sbjct: 134 ADLNNIVK---CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 190 Query: 329 DLGLAVKIPEGDLIRGRVGTVGYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 D GLA D + G V T Y APE+ LN Y + D W +GC++ E++ G++ F G Sbjct: 191 DFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 248 Query: 388 RKEKVKREEVDRRVLETEEVYSHKFSEE---------------------------AKSIC 420 + + + R V K S E A + Sbjct: 249 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLL 308 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + +L D+ +R+ AA+ H +F Sbjct: 309 EKMLVLDSDKRIT-----AAQALAHAYFAQ 333 >4AU8-A nrPDB Length = 296 Score = 261 bits (666), Expect = 1e-69, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 123/295 (41%), Gaps = 36/295 (12%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + + +G+G +G V + R T ++ A KR+ S AL E +L+++ + Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKHK 65 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 +V L + L LV + DLK + ++ N + E + ++L GL H Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCD-QDLKKY-FDSCNGDLDPEIVKSFLFQLLKGLGFCHS 123 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVLNNQR-Y 362 N ++RDLKP+N+L++ G ++++D GLA V T+ Y P+VL + Y Sbjct: 124 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 183 Query: 363 GLSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDR----------------RVLETE 405 S D W GC+ E+ G+ F G + + + R + Sbjct: 184 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 243 Query: 406 EVYS---------HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 +Y K + + + + LL + QR+ A E +HP+F + Sbjct: 244 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFSDF 293 >2HW6-A nrPDB Length = 307 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 78/301 (25%), Positives = 122/301 (40%), Gaps = 43/301 (14%) Query: 183 KNTFRQY-RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ ++ +LG+G + +V GK YA K +EK+ R S E + L + Sbjct: 11 EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR---SRVFREVETLYQC 67 Query: 242 N-SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 ++ ++ L +E LV + GG + HI + F E A ++ L+ Sbjct: 68 QGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKH--FNEREASRVVRDVAAALD 125 Query: 301 DLHRENTVYRDLKPENILLDDY---GHIRISDLGLAVKIP--------EGDLIRGRVGTV 349 LH + +RDLKPENIL + ++I D L + + G+ Sbjct: 126 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 185 Query: 350 GYMAPEVL-----NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR---------------K 389 YMAPEV+ Y D W LG ++Y M+ G PF G Sbjct: 186 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 245 Query: 390 EKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 + E + E + S EAK + LL +DAKQRL AA+V +HP+ + Sbjct: 246 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLS-----AAQVLQHPWVQ 300 Query: 450 N 450 Sbjct: 301 G 301 >5EFQ-A nrPDB Length = 347 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 76/323 (23%), Positives = 140/323 (43%), Gaps = 52/323 (16%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + F ++G+G +G+V + + TG+M A K++ +K A+ E +IL ++ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDN-EKEGFPITAIREIKILRQLTH 69 Query: 244 QFVVNLAYAYETKDA----------LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 Q ++N+ K+ LV M+ DL + + G F E + Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFNENHIKSFMR 127 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP--EGDLIRGRVGTVGY 351 +++ GL+ H++N ++RD+K NILL++ G I+++D GLA E +V T+ Y Sbjct: 128 QLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWY 187 Query: 352 MAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR----------- 399 PE+L +RY + D W GC++ E+ + F+ +E + E + R Sbjct: 188 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWP 247 Query: 400 --------RVLETEEVYSHKFSEE-------AKSICKMLLTKDAKQRLGCQEEGAAEVKR 444 ++ ++ Y K EE A + +L D +R A + + Sbjct: 248 DVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCT-----AEQALQ 302 Query: 445 HPFFRNMNFKRLEAGMLDPPFVP 467 F R++ E + PP +P Sbjct: 303 CEFLRDV-----EPSKMPPPDLP 320 >3E7O-A nrPDB Length = 360 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 133/329 (40%), Gaps = 57/329 (17%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 ++Q + +G G G VCA G A K+L + + + A E +L+ VN Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSR-PFQNQTHAKRAYRELVLLKCVNH 80 Query: 244 QFVVNLAYAY------ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + +++L + E + LV+ +M+ ++ + + + ER + ++LC Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIHMELDHERMSYLLYQMLC 135 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL 357 G++ LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVI 195 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV---------------- 401 Y + D W +GC++ E+++G F+G + +V ++ Sbjct: 196 LGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVR 255 Query: 402 -----------LETEEVYSHKF-----------SEEAKSICKMLLTKDAKQRLGCQEEGA 439 + EE++ + +A+ + +L D +R+ Sbjct: 256 NYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----V 310 Query: 440 AEVKRHPFFRNMNFKRLEAGMLDPPFVPD 468 E RHP+ + PP + D Sbjct: 311 DEALRHPYIT--VWYDPAEAEAPPPQIYD 337 >5AWM-A nrPDB Length = 394 Score = 259 bits (662), Expect = 3e-69, Method: Composition-based stats. Identities = 69/331 (20%), Positives = 130/331 (39%), Gaps = 61/331 (18%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + R +G G G VCA T + A K+L + + A E ++++ VN + Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHK 103 Query: 245 FVVNLAYAY------ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 ++ L A+ E + LV+ +M+ ++ + + +R + ++LCG Sbjct: 104 NIIGLLNAFTPQRNLEEFQDVYLVMELMD-----ANLCQVIQMDLDHDRMSYLLYQMLCG 158 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN 358 ++ LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 159 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 218 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV----------------- 401 Y + D W +GC++ EMI G F G + ++ ++ Sbjct: 219 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 278 Query: 402 ----------LETEEVYSHKFSE------------EAKSICKMLLTKDAKQRLGCQEEGA 439 + ++ +A+++ +L D +QR+ Sbjct: 279 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS-----V 333 Query: 440 AEVKRHPFFRNMNFKRLEAGMLDPPFVPDPR 470 E +H + +A +D P P+P Sbjct: 334 DEALKHEYIN----VWYDAEEVDAP-APEPY 359 >4MYG-A nrPDB Length = 372 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 77/373 (20%), Positives = 144/373 (38%), Gaps = 69/373 (18%) Query: 169 RFLQWKWLERQPVTKNTFRQYRV------LGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++ K +Q V K + + +G G +G VC+ + +G+ A K+L + Sbjct: 22 SLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PF 80 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDAL------CLVLTIMNGGDLKFHIY 276 + A E +L+ + + V+ L + +L LV+ M + + Sbjct: 81 QSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-----QTDLQ 135 Query: 277 NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI 336 + F EE+ + ++L GL+ +H V+RDLKP N+ +++ ++I D GLA Sbjct: 136 KIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-- 193 Query: 337 PEGDLIRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE 395 + G V T Y APEV+ + Y + D W +GC++ EM+ G++ F+G+ + Sbjct: 194 HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 253 Query: 396 EVDRR--------------------VLETEEVYSHKF-------SEEAKSICKMLLTKDA 428 ++ + + + F S +A + + +L D Sbjct: 254 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 313 Query: 429 KQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKG 488 +RL AA+ HPFF PF + D + Sbjct: 314 DKRLT-----AAQALTHPFFE--------------PFRDPEEETEAQQPFDDSL--EHEK 352 Query: 489 VNLDHTDDDFYSK 501 + +D Y + Sbjct: 353 LTVDEWKQHIYKE 365 >6NPU-A nrPDB Length = 298 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 113/281 (40%), Gaps = 21/281 (7%) Query: 163 DSMFFD---RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEK 219 ++++F + +W+ +ER +T LG G +GEV + A K L++ Sbjct: 8 ENLYFQGSPNYDKWE-MERTDITMKH-----KLGGGQYGEVYEGVWKKYSLTVAVKTLKE 61 Query: 220 KRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG 279 ++ L E +++++ +V L + ++ M G+L ++ Sbjct: 62 DTME----VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECN 117 Query: 280 NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG 339 L+ A +I +E L ++N ++RDL N L+ + ++++D GL+ + G Sbjct: 118 RQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-G 176 Query: 340 DLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKRE 395 D G + + APE L ++ + D W G L++E+ G SP+ G Sbjct: 177 DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY- 235 Query: 396 EVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 E+ + E E+ + + + R E Sbjct: 236 ELLEKDYRMER--PEGCPEKVYELMRACWQWNPSDRPSFAE 274 >6QAU-A nrPDB Length = 280 Score = 257 bits (658), Expect = 7e-69, Method: Composition-based stats. Identities = 70/280 (25%), Positives = 122/280 (43%), Gaps = 20/280 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVR-ATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 V + + ++G G F V + R T A K + KK + K + + E +IL+ Sbjct: 8 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKS--QILLGKEIKILK 65 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 ++ + +V L E +++ LV+ NGGDL ++ G E+ + +I + Sbjct: 66 ELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKG--TLSEDTIRVFLHQIAAAM 123 Query: 300 EDLHRENTVYRDLKPENILLD---------DYGHIRISDLGLAVKIPEGDLIRGRVGTVG 350 LH + ++RDLKP+NILL I+I+D G A + + G+ Sbjct: 124 RILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPM 183 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 YMAPEV+ +Q Y D W +G +IY+ + G+ PF+ + R ++ + Sbjct: 184 YMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSI-PR 242 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + S ++ LL ++ K R+ HPF Sbjct: 243 ETSPYLANLLLGLLQRNQKDRM-----DFEAFFSHPFLEQ 277 >2XS0-A nrPDB Length = 386 Score = 257 bits (657), Expect = 8e-69, Method: Composition-based stats. Identities = 68/331 (20%), Positives = 130/331 (39%), Gaps = 57/331 (17%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 ++ + +G G G VCA + A K+L + + + A E +++ VN Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNH 84 Query: 244 QFVVNLAYAY------ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + ++ L + E + +V+ +M+ ++ + + ER + ++LC Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-----NLCQVIQMELDHERMSYLLYQMLC 139 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL 357 G++ LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVI 199 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV---------------- 401 Y + D W +GC++ EMI+G F G + +V ++ Sbjct: 200 LGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVR 259 Query: 402 -----------LETEEVYSHKFSE-----------EAKSICKMLLTKDAKQRLGCQEEGA 439 E+++ +A+ + +L DA +R+ Sbjct: 260 TYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----V 314 Query: 440 AEVKRHPFFRNMNFKRLEAGMLDPPFVPDPR 470 E +HP+ + PP +PD + Sbjct: 315 DEALQHPYIN--VWYDPSEAEAPPPKIPDKQ 343 >6DTL-A nrPDB Length = 364 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 69/334 (20%), Positives = 135/334 (40%), Gaps = 43/334 (12%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +GKG +G VC+ T + A K++ + L E ++L ++ + +V + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIA-NAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 96 Query: 252 AYETK-----DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 + + + +M+ DL I + N EE ++ +IL GL+ +H N Sbjct: 97 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRS--NQALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR-YGLS 365 ++RDLKP N+LL+ ++I D GLA E D + V T Y APE+L N Y + Sbjct: 154 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 213 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD-------------------RRVLETEE 406 D W +GC+ E+++ + F GR + + R + + Sbjct: 214 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 273 Query: 407 VYSHKFSEE-------AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAG 459 +++ A + + +LT D ++R+ + HP+ +++ + Sbjct: 274 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL-----DALAHPYLNSLH-DISDEP 327 Query: 460 MLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDH 493 PF D + +++ + + + Sbjct: 328 ECTIPFNFDFEN-HALSEEQMKELIYREALAFNP 360 >4XEY-B nrPDB Length = 408 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 51/267 (19%), Positives = 103/267 (38%), Gaps = 12/267 (4%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN 233 ++ + + LG G +GEV + A K L++ ++ L Sbjct: 115 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLK 170 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 E +++++ +V L + ++ M G+L ++ L+ A Sbjct: 171 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 230 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVG 350 +I +E L ++N ++RDL N L+ + ++++D GL+ + GD G + Sbjct: 231 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIK 289 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYS 409 + APE L ++ + D W G L++E+ G SP+ G E+ + E Sbjct: 290 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY-ELLEKDYRMER--P 346 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQE 436 E+ + + + R E Sbjct: 347 EGCPEKVYELMRACWQWNPSDRPSFAE 373 >1JNK-A nrPDB Length = 423 Score = 256 bits (653), Expect = 3e-68, Method: Composition-based stats. Identities = 65/331 (19%), Positives = 129/331 (38%), Gaps = 57/331 (17%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 ++ + +G G G VCA + A K+L + + + A E +++ VN Sbjct: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNH 120 Query: 244 QFVVNLAYAY------ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + +++L + E + LV+ +M+ ++ + + ER + ++LC Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLC 175 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL 357 G++ LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV---------------- 401 Y + D W +GC++ EM+ + F GR + +V ++ Sbjct: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Query: 402 -----------LETEEVYSHKFSE-----------EAKSICKMLLTKDAKQRLGCQEEGA 439 L +++ +A+ + +L D +R+ Sbjct: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----V 350 Query: 440 AEVKRHPFFRNMNFKRLEAGMLDPPFVPDPR 470 + +HP+ + PP + D + Sbjct: 351 DDALQHPYIN--VWYDPAEVEAPPPQIYDKQ 379 >2F9G-A nrPDB Length = 353 Score = 255 bits (652), Expect = 4e-68, Method: Composition-based stats. Identities = 67/326 (20%), Positives = 128/326 (39%), Gaps = 57/326 (17%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F+ +LG+G +G VC+ + TG++ A K++E K L E +IL+ + Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHE 69 Query: 245 FVVNLA-----YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 ++ + ++E + + ++ +M DL I ++ ++ + L + Sbjct: 70 NIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI---STQMLSDDHIQYFIYQTLRAV 125 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-----------DLIRGRVGT 348 + LH N ++RDLKP N+L++ +++ D GLA I E + V T Sbjct: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 Query: 349 VGYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE-- 405 Y APEV L + +Y + D W GC++ E+ + F GR + + + + Sbjct: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Query: 406 --------------------------EVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGA 439 E + + + + + +L D +R+ A Sbjct: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT-----A 300 Query: 440 AEVKRHPFFRN-MNFKRLEAGMLDPP 464 E HP+ + + G PP Sbjct: 301 KEALEHPYLQTYHDPNDEPEGEPIPP 326 >2H8H-A nrPDB Length = 535 Score = 254 bits (650), Expect = 6e-68, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 114/266 (42%), Gaps = 12/266 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + + + + R LG+G FGEV T + A K L+ + L E Q Sbjct: 260 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQ 314 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +++K+ + +V L A +++ + +V M+ G L + + + AA+I Sbjct: 315 VMKKLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 373 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMAP 354 G+ + R N V+RDL+ NIL+ + +++D GLA I + + +G + + AP Sbjct: 374 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 433 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 E R+ + D W G L+ E+ G+ P+ G + ++V+R + Sbjct: 434 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM---PCPPECP 490 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGA 439 E + K+ ++R + A Sbjct: 491 ESLHDLMCQCWRKEPEERPTFEYLQA 516 >3FI2-A nrPDB Length = 353 Score = 254 bits (650), Expect = 6e-68, Method: Composition-based stats. Identities = 62/309 (20%), Positives = 123/309 (39%), Gaps = 55/309 (17%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 ++ + +G G G VCA + A K+L + + + A E +++ VN Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNH 82 Query: 244 QFVVNLAYAY------ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + +++L + E + LV+ +M+ ++ + + ER + ++LC Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLC 137 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL 357 G++ LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 197 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV---------------- 401 Y + D W +GC++ EM+ + F GR + +V ++ Sbjct: 198 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 257 Query: 402 -----------LETEEVYSHKFSE-----------EAKSICKMLLTKDAKQRLGCQEEGA 439 L +++ +A+ + +L D +R+ Sbjct: 258 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----V 312 Query: 440 AEVKRHPFF 448 + +HP+ Sbjct: 313 DDALQHPYI 321 >4NST-A nrPDB Length = 351 Score = 254 bits (650), Expect = 7e-68, Method: Composition-based stats. Identities = 76/323 (23%), Positives = 140/323 (43%), Gaps = 52/323 (16%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + F ++G+G +G+V + + TG++ A K++ +K A+ E +IL ++ Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDN-EKEGFPITAIREIKILRQLIH 71 Query: 244 QFVVNLAYAYETKDA----------LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 + VVN+ K LV M+ DL + + G F E+ + Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFSEDHIKSFMK 129 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI--PEGDLIRGRVGTVGY 351 +++ GLE H++N ++RD+K NILL++ G I+++D GLA E +V T+ Y Sbjct: 130 QLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWY 189 Query: 352 MAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR----------- 399 PE+L +RY + D W GC++ E+ + F+ E + E + R Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWP 249 Query: 400 --------RVLETEEVYSHKFSEE-------AKSICKMLLTKDAKQRLGCQEEGAAEVKR 444 ++ ++ Y + EE A + +LT D +R A + + Sbjct: 250 DVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCT-----AEQTLQ 304 Query: 445 HPFFRNMNFKRLEAGMLDPPFVP 467 F +++ E + PP +P Sbjct: 305 SDFLKDV-----ELSKMAPPDLP 322 >6F3F-A nrPDB Length = 455 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 114/266 (42%), Gaps = 12/266 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + + + + R LG+G FGEV T + A K L+ + L E Q Sbjct: 180 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQ 234 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +++K+ + +V L A +++ + +V MN G L + + + +A+I Sbjct: 235 VMKKLRHEKLVQLY-AVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIA 293 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMAP 354 G+ + R N V+RDL+ NIL+ + +++D GLA I + + +G + + AP Sbjct: 294 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 353 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 E R+ + D W G L+ E+ G+ P+ G + ++V+R + Sbjct: 354 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM---PCPPECP 410 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGA 439 E + K+ ++R + A Sbjct: 411 ESLHDLMCQCWRKEPEERPTFEYLQA 436 >2FO0-A nrPDB Length = 495 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 50/267 (18%), Positives = 103/267 (38%), Gaps = 12/267 (4%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN 233 ++ + + LG G +GEV + A K L++ ++ L Sbjct: 207 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLK 262 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 E +++++ +V L + ++ M G+L ++ L+ A Sbjct: 263 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 322 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVG 350 +I +E L ++N ++R+L N L+ + ++++D GL+ + GD G + Sbjct: 323 QISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIK 381 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYS 409 + APE L ++ + D W G L++E+ G SP+ G E+ + E Sbjct: 382 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY-ELLEKDYRMER--P 438 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQE 436 E+ + + + R E Sbjct: 439 EGCPEKVYELMRACWQWNPSDRPSFAE 465 >3OHT-A nrPDB Length = 389 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 67/301 (22%), Positives = 127/301 (42%), Gaps = 46/301 (15%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 ++ +G G +G VC+ +G A K+L + + E ++L+ + Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSR-PFQSIIHAKRTYRELRLLKHMKH 109 Query: 244 QFVVNLAYAY------ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + V+ L + E + + LV +M G DL + ++ F +IL Sbjct: 110 ENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNNIVK---CQKLTDDHVQFLIYQILR 165 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV- 356 GL+ +H + ++RDLKP N+ +++ ++I D GLA D + G V T Y APE+ Sbjct: 166 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRAPEIM 223 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR----------------- 399 LN Y ++ D W +GC++ E++ G++ F G + +++ R Sbjct: 224 LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHE 283 Query: 400 ---RVLETEEVYSHKF-------SEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 + ++ F + A + + +L D +R+ A+E HP+F Sbjct: 284 ARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRIT-----ASEALAHPYFS 338 Query: 450 N 450 Sbjct: 339 Q 339 >5SYS-A nrPDB Length = 286 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 113/266 (42%), Gaps = 12/266 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + + + + R LG+G FGE T + A K L+ + L E Q Sbjct: 11 DAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQ 65 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +++K+ + +V L A +++ + +V M+ G L + + + AA+I Sbjct: 66 VMKKLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIA 124 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMAP 354 G+ + R N V+RDL+ NIL+ + +++D GLA I + + +G + + AP Sbjct: 125 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 184 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 E R+ + D W G L+ E+ G+ P+ G + ++V+R + Sbjct: 185 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM---PCPPECP 241 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGA 439 E + KD ++R + A Sbjct: 242 ESLHDLMCQCWRKDPEERPTFEYLQA 267 >4BGQ-A nrPDB Length = 304 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 122/298 (40%), Gaps = 38/298 (12%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 N F V+G+G +G V C+ + T ++ A K+ K + + + L E ++L + Sbjct: 10 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKF-KDSEENEEVKETTLRELKMLRTL 68 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + +V L A+ + L LV + L+ + G E+ Y +++ + Sbjct: 69 KQENIVELKEAFRRRGKLYLVFEYVEKNMLE--LLEEMPNGVPPEKVKSYIYQLIKAIHW 126 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL--IRGRVGTVGYMAPEVLNN 359 H+ + V+RD+KPEN+L+ +++ D G A + EG+ V T Y +PE+L Sbjct: 127 CHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG 186 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV------------ 407 YG S D W +GC++ E+ +GQ F G E + + + + Sbjct: 187 APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFH 246 Query: 408 ---YS---HKFSEEAK----------SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 + H S E + + K LL D R + HP F+ Sbjct: 247 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRY-----LTEQCLNHPTFQ 299 >3V5Q-A nrPDB Length = 297 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 106/282 (37%), Gaps = 31/282 (10%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQV-----RATGKMYACKRLEKKRIKKRKGESMALN 233 Q + + R LG+G FG+V + + A K L+ + RK Sbjct: 10 QHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD---FQR 66 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG-------------- 279 E ++L + + +V D L +V M GDL + G Sbjct: 67 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 126 Query: 280 NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG 339 + L A++I G+ L ++ V+RDL N L+ ++I D G++ + Sbjct: 127 KGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYST 186 Query: 340 DLIRGRVGT---VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKRE 395 D R T + +M PE + +++ D W G +++E+ G+ P+ E Sbjct: 187 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIE 246 Query: 396 -EVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 RVLE V E + ++ +QRL +E Sbjct: 247 CITQGRVLERPRVCPK----EVYDVMLGCWQREPQQRLNIKE 284 >4QNY-A nrPDB Length = 354 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 129/306 (42%), Gaps = 45/306 (14%) Query: 183 KNTFRQYRVLGKGGFGEVCACQV-RATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + R++G G +G V + ++ ++ A KR+ K+ ++ L E ++L Sbjct: 19 DDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHF 78 Query: 242 NSQFVVNLAYAY-----ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 N ++ L E D +V+ IM DLK + + E F+ + L Sbjct: 79 NDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRS--GQELTEAHIQFFIYQAL 135 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE-GDLIRGRVGTVGYMAPE 355 L +H ++RD+ P NIL++ ++I D GLA + + G+ + V Y APE Sbjct: 136 RALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPE 195 Query: 356 -VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRK------------------------- 389 V+ ++ Y D WG+GC++ E++ + F+G+ Sbjct: 196 LVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGS 255 Query: 390 ---EKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHP 446 +K +++ R + + Y S EA + + +L + K+R+ + RHP Sbjct: 256 SAAQKYLKKKSHRPQADWRQRYP-TASPEALDLLRHMLVFNPKRRITVL-----QAMRHP 309 Query: 447 FFRNMN 452 F ++ Sbjct: 310 FLEQLH 315 >5H2U-A nrPDB Length = 267 Score = 252 bits (643), Expect = 4e-67, Method: Composition-based stats. Identities = 57/259 (22%), Positives = 97/259 (37%), Gaps = 9/259 (3%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + F R LG G FGEV + A K + + + + M +E Q + Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLL---HQQMLQSEIQAM 56 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 +K+ + ++ L D + ++ +M G L + + L A ++ G Sbjct: 57 KKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEG 116 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG-YMAPEVL 357 + L +N ++RDL NIL+ + ++ D GLA I E + + APE L Sbjct: 117 MCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL 176 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 + Y D W G L++EM GQ P+ G VD + Sbjct: 177 SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRM---PCPLECPPSV 233 Query: 417 KSICKMLLTKDAKQRLGCQ 435 + +D +QR + Sbjct: 234 HKLMLTCWCRDPEQRPTFK 252 >3PPZ-A nrPDB Length = 309 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 65/320 (20%), Positives = 122/320 (38%), Gaps = 28/320 (8%) Query: 157 PFHEY----LDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY 212 P +Y ++++F + + + +G G FG V + G Sbjct: 9 PMSDYDIPTTENLYFQGAMD---GDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH--GSDV 63 Query: 213 ACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLK 272 A K L ++ + + L E I++++ +V A L +V ++ G L Sbjct: 64 AVKILMEQDFHAER-VNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLY 122 Query: 273 FHIYNMG-NPGFEEERALFYAAEILCGLEDLHREN--TVYRDLKPENILLDDYGHIRISD 329 ++ G +E R L A ++ G+ LH N V+RDLK N+L+D +++ D Sbjct: 123 RLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCD 182 Query: 330 LGLAVKIPEGDLI-RGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 GL+ L + GT +MAPEVL ++ D + G +++E+ Q P+ Sbjct: 183 FGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNL 242 Query: 389 KEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 V + E + + +I + T + +R ++ R P Sbjct: 243 NPAQVVAAVGFKCKRLE--IPRNLNPQVAAIIEGCWTNEPWKRPSF--ATIMDLLR-PLI 297 Query: 449 RNMNFKRLEAGMLDPPFVPD 468 ++ + PP D Sbjct: 298 KS---------AVPPPNRSD 308 >6GQK-A nrPDB Length = 328 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 111/326 (34%), Gaps = 43/326 (13%) Query: 137 PCKELFSACAQSVH--EYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGK 194 P E+ + + Y +P D +W++ +N + LG Sbjct: 5 PMYEVQWKVVEESNGNNYSYIDPTQLPYD-------HKWEF------PRNRLSFGKTLGA 51 Query: 195 GGFGEVCACQVRATGK-----MYACKRLEKKRIKKRKGESMALNEKQILEKV-NSQFVVN 248 G FG+V + K A K L+ ++E ++L + N + +VN Sbjct: 52 GAFGKVVEATAQGLIKSDAAMTVAVKMLKPSA--HSTEREALMSELKVLSYLGNHENIVN 109 Query: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG--------------FEEERALFYAAE 294 L A ++ GDL + + E L ++ + Sbjct: 110 LLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQ 169 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR---VGTVGY 351 + G+ L +N ++RDL NILL +I D GLA I + V + Sbjct: 170 VAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNARLPVKW 229 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 MAPE + N Y D W G ++E+ G SP+ G K ++ + Sbjct: 230 MAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRM--SSPE 287 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQE 436 E I K D +R ++ Sbjct: 288 YAPAEMYDIMKTCWDADPDKRPTFKQ 313 >6CKI-A nrPDB Length = 316 Score = 251 bits (641), Expect = 7e-67, Method: Composition-based stats. Identities = 83/301 (27%), Positives = 126/301 (41%), Gaps = 43/301 (14%) Query: 183 KNTFRQYR-VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ ++ VLG+G V C T + YA K +EK+ R S E ++L + Sbjct: 11 EDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIR---SRVFREVEMLYQC 67 Query: 242 N-SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + V+ L +E +D LV M GG + HI+ + F E A ++ L+ Sbjct: 68 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH--FNELEASVVVQDVASALD 125 Query: 301 DLHRENTVYRDLKPENILLDDYGH---IRISDLGLAVKIP--------EGDLIRGRVGTV 349 LH + +RDLKPENIL + ++I D GL I + G+ Sbjct: 126 FLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSA 185 Query: 350 GYMAPEVL-----NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR---------------K 389 YMAPEV+ Y D W LG ++Y ++ G PF GR Sbjct: 186 EYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPAC 245 Query: 390 EKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 + + E + E + S AK + LL +DAKQRL AA+V +HP+ + Sbjct: 246 QNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLS-----AAQVLQHPWVQ 300 Query: 450 N 450 Sbjct: 301 G 301 >6E2O-A nrPDB Length = 295 Score = 250 bits (639), Expect = 1e-66, Method: Composition-based stats. Identities = 64/259 (24%), Positives = 110/259 (42%), Gaps = 9/259 (3%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 VLGKG +G V A + + A K + + + + E + + + + +V Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPE---RDSRYSQPLHEEIALHKHLKHKNIVQYL 85 Query: 251 YAYETKDALCLVLTIMNGGDLKFHIY-NMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 ++ + + + + GG L + G E+ FY +IL GL+ LH V+ Sbjct: 86 GSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVH 145 Query: 310 RDLKPENILLDD-YGHIRISDLGLAVKIPEGDLIR-GRVGTVGYMAPEVLNNQR--YGLS 365 RD+K +N+L++ G ++ISD G + ++ + GT+ YMAPE+++ YG + Sbjct: 146 RDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKA 205 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLT 425 D W LGC I EM G+ PF E + + S EAK+ Sbjct: 206 ADIWSLGCTIIEMATGKPPFYELGEPQA-AMFKVGMFKVHPEIPESMSAEAKAFILKCFE 264 Query: 426 KDAKQRLGCQEEGAAEVKR 444 D +R + E + Sbjct: 265 PDPDKRACANDLLVDEFLK 283 >2DQ7-X nrPDB Length = 283 Score = 250 bits (638), Expect = 2e-66, Method: Composition-based stats. Identities = 60/260 (23%), Positives = 110/260 (42%), Gaps = 12/260 (4%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + + + + + LG G FGEV K A K L+ + L E QI+ Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGTMSPES----FLEEAQIM 58 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 +K+ +V L A +++ + +V MN G L + + + + AA++ G Sbjct: 59 KKLKHDKLVQLY-AVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 117 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMAPEV 356 + + R N ++RDL+ NIL+ + +I+D GLA I + + +G + + APE Sbjct: 118 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 177 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 R+ + D W G L+ E++ G+ P+ G + E+V+R Sbjct: 178 ALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRM---PCPQDCPIS 234 Query: 416 AKSICKMLLTKDAKQRLGCQ 435 + KD ++R + Sbjct: 235 LHELMIHCWKKDPEERPTFE 254 >1TKI-A nrPDB Length = 321 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 67/269 (24%), Positives = 116/269 (43%), Gaps = 12/269 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + LG+G FG V C ++ K Y K ++ K + + E IL Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT----DQVLVKKEISILNIARH 60 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + +++L ++E+ + L ++ ++G D+ I N E + Y ++ L+ LH Sbjct: 61 RNILHLHESFESMEELVMIFEFISGLDIFERI-NTSAFELNEREIVSYVHQVCEALQFLH 119 Query: 304 RENTVYRDLKPENILLDDY--GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 N + D++PENI+ I+I + G A ++ GD R Y APEV + Sbjct: 120 SHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDV 179 Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 + D W LG L+Y ++ G +PF + E + +E + S EA Sbjct: 180 VSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVD 239 Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 LL K+ K R+ A+E +HP+ + Sbjct: 240 RLLVKERKSRMT-----ASEALQHPWLKQ 263 >5G6V-A nrPDB Length = 324 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 129/297 (43%), Gaps = 37/297 (12%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 T+ + LG+G + V + + T + A K + + + A+ E +L+ + Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH--EEGAPCTAIREVSLLKDLK 58 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +V L T+ +L LV ++ DLK ++ + GN + ++L GL Sbjct: 59 HANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGN-IINMHNVKLFLFQLLRGLAYC 116 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAV-KIPEGDLIRGRVGTVGYMAPEVLNN-Q 360 HR+ ++RDLKP+N+L+++ G ++++D GLA K V T+ Y P++L Sbjct: 117 HRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGST 176 Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKR-----------EEVDRRVLETEEVYS 409 Y D WG+GC+ YEM G+ F G + + EE +L EE + Sbjct: 177 DYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKT 236 Query: 410 HKFSE---------------EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 + + + + + LL + + R+ A + +HPFF ++ Sbjct: 237 YNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-----AEDAMKHPFFLSL 288 >2PL0-A nrPDB Length = 289 Score = 249 bits (636), Expect = 3e-66, Method: Composition-based stats. Identities = 61/264 (23%), Positives = 109/264 (41%), Gaps = 14/264 (5%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNE 234 W + V + T + LG G FGEV A K L++ + L E Sbjct: 14 WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLKQGSMSP----DAFLAE 68 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 +++++ Q +V L A T++ + ++ M G L + + L AA+ Sbjct: 69 ANLMKQLQHQRLVRLY-AVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 127 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGY 351 I G+ + N ++RDL+ NIL+ D +I+D GLA I + + R G + + Sbjct: 128 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNE-YTAREGAKFPIKW 186 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 APE +N + + D W G L+ E++ G+ P+ G + ++R V Sbjct: 187 TAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM---VRPD 243 Query: 411 KFSEEAKSICKMLLTKDAKQRLGC 434 EE + ++ + + R Sbjct: 244 NCPEELYQLMRLCWKERPEDRPTF 267 >5X02-A nrPDB Length = 347 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 70/323 (21%), Positives = 128/323 (39%), Gaps = 47/323 (14%) Query: 163 DSMFF-DRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-----MYACKR 216 D+ +F F ++++ + + +VLG G FG+V K A K Sbjct: 26 DNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKM 85 Query: 217 LEKKRIKKRKGESMALNEKQILEKVN-SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275 L++K + ++E +++ ++ + +VNL A + L+ GDL ++ Sbjct: 86 LKEKADSSER--EALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYL 143 Query: 276 YNMGNPGFEEERA----------------------LFYAAEILCGLEDLHRENTVYRDLK 313 + F E+ L +A ++ G+E L ++ V+RDL Sbjct: 144 RS-KREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLA 202 Query: 314 PENILLDDYGHIRISDLGLAVKIPEGDLIRGR---VGTVGYMAPEVLNNQRYGLSPDYWG 370 N+L+ ++I D GLA I R V +MAPE L Y + D W Sbjct: 203 ARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWS 262 Query: 371 LGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAK 429 G L++E+ G +P+ G ++ + + ++ + +EE I + D++ Sbjct: 263 YGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYA--TEEIYIIMQSCWAFDSR 320 Query: 430 QR---------LGCQEEGAAEVK 443 +R LGCQ A E Sbjct: 321 KRPSFPNLTSFLGCQLADAEEAM 343 >3ZDU-A nrPDB Length = 325 Score = 249 bits (635), Expect = 4e-66, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 121/296 (40%), Gaps = 38/296 (12%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + +G+G +G V C+ + TG++ A K ++ ++ +A+ E + L++ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERP--EQSVNKIAMREIKFLKQF 58 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + + +VNL + K + LV ++ L G E +R Y +IL ++ Sbjct: 59 HHENLVNLIEVFRQKKKIHLVFEFIDHTVLDEL--QHYCHGLESKRLRKYLFQILRAIDY 116 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPE-VLNN 359 LH N ++RD+KPENIL+ G ++ D G A + GD+ V T Y APE VL + Sbjct: 117 LHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE---- 415 YG D W LGC+I EM G + ++ +V + FS+ Sbjct: 177 TSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFA 236 Query: 416 -----------------------AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 I L D R+ ++++ H +F Sbjct: 237 GVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRIS-----SSDLLHHEYF 287 >3KRL-A nrPDB Length = 335 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 67/329 (20%), Positives = 125/329 (37%), Gaps = 39/329 (11%) Query: 132 KLLQKPCKELFSACAQSV--HEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQY 189 K QKP ++ +S + Y +P + E+ +N + Sbjct: 5 KYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYN-------------EKWEFPRNNLQFG 51 Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR---KGESMALNEKQILEKV-NSQF 245 + LG G FG+V GK A ++ K +K + ++E +I+ + + Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 111 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF---------EEERA-----LFY 291 +VNL A + ++ GDL + PG EE+ L + Sbjct: 112 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHF 171 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI---RGRVGT 348 ++++ G+ L +N ++RD+ N+LL + +I D GLA I Sbjct: 172 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLP 231 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEV 407 V +MAPE + + Y + D W G L++E+ G +P+ G K ++ + + + Sbjct: 232 VKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQ- 290 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + SI + + R Q+ Sbjct: 291 -PAFAPKNIYSIMQACWALEPTHRPTFQQ 318 >4AN9-A nrPDB Length = 301 Score = 248 bits (634), Expect = 5e-66, Method: Composition-based stats. Identities = 66/284 (23%), Positives = 123/284 (43%), Gaps = 15/284 (5%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 + + + F + LG G G V + +G + A K + + K + + E Sbjct: 1 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIREL 58 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 Q+L + NS ++V A+ + + + + M+GG L + G E+ + + Sbjct: 59 QVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAV 116 Query: 296 LCGLEDL-HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAP 354 + GL L + ++RD+KP NIL++ G I++ D G++ ++ + ++ VGT YM+P Sbjct: 117 IKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-EMANEFVGTRSYMSP 175 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK-FS 413 E L Y + D W +G + EM G+ P R E +D V E FS Sbjct: 176 ERLQGTHYSVQSDIWSMGLSLVEMAVGRYP---RPPMAIFELLDYIVNEPPPKLPSAVFS 232 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLE 457 E + L K+ +R ++ H F + + + ++ Sbjct: 233 LEFQDFVNKCLIKNPAER-----ADLKQLMVHAFIKRSDAEEVD 271 >4EBW-A nrPDB Length = 304 Score = 247 bits (632), Expect = 7e-66, Method: Composition-based stats. Identities = 52/284 (18%), Positives = 110/284 (38%), Gaps = 16/284 (5%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG---KMYACKRLEK 219 ++++F + + + + R +G+G FG+V + A K + Sbjct: 18 ENLYFQGAMGSSTRD-YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN 76 Query: 220 KRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG 279 L E + + + +V L T++ + +++ + G+L+ + + Sbjct: 77 CT--SDSVREKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFL-QVR 132 Query: 280 NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG 339 + + YA ++ L L + V+RD+ N+L+ +++ D GL+ + + Sbjct: 133 KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDS 192 Query: 340 DLIRGRVG--TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREE 396 + G + +MAPE +N +R+ + D W G ++E++ G PF+G K Sbjct: 193 TYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND---- 248 Query: 397 VDRRVLETEE-VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGA 439 V R+ E S+ D +R E A Sbjct: 249 VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKA 292 >3GC9-A nrPDB Length = 370 Score = 247 bits (631), Expect = 1e-65, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 127/328 (38%), Gaps = 51/328 (15%) Query: 157 PFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKR 216 + + W Q + R +G G +G VC+ + A K+ Sbjct: 6 EMSGPRAGFYRQELNKTVWEVPQ-----RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKK 60 Query: 217 LEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAY------ETKDALCLVLTIMNGGD 270 L + + E ++L+ + + V+ L + E + LV T+M G D Sbjct: 61 LSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GAD 118 Query: 271 LKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDL 330 L + + +E F ++L GL+ +H ++RDLKP N+ +++ +RI D Sbjct: 119 LNNIVKS---QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDF 175 Query: 331 GLAVKIPEGDLIRGRVGTVGYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRK 389 GLA + + + G V T Y APE+ LN Y + D W +GC++ E+++G++ F G Sbjct: 176 GLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSD 233 Query: 390 EKVKREEVDRRVLETEEVYSHKFSEE---------------------------AKSICKM 422 + + + V K S E A + Sbjct: 234 YIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGR 293 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 +L D+ QR+ AAE H +F Sbjct: 294 MLVLDSDQRVS-----AAEALAHAYFSQ 316 >3TT0-A nrPDB Length = 382 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 62/306 (20%), Positives = 127/306 (41%), Gaps = 37/306 (12%) Query: 163 DSMFFDRFL----QWKWLE--RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK------ 210 ++++F L +++ E R + ++ + LG+G FG+V + K Sbjct: 42 ENLYFQGMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRV 101 Query: 211 -MYACKRLEKKRIKKRKGESMALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNG 268 A K L+ +K S ++E ++++ + + ++NL A L +++ + Sbjct: 102 TKVAVKMLKSDATEK--DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 159 Query: 269 GDLKFHIYNMGNPGF---------EEERA-----LFYAAEILCGLEDLHRENTVYRDLKP 314 G+L+ ++ PG EE+ + A ++ G+E L + ++RDL Sbjct: 160 GNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAA 219 Query: 315 ENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGL 371 N+L+ + ++I+D GLA I D + V +MAPE L ++ Y D W Sbjct: 220 RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 279 Query: 372 GCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ 430 G L++E+ G SP+ G + + + + + E + + Q Sbjct: 280 GVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK---PSNCTNELYMMMRDCWHAVPSQ 336 Query: 431 RLGCQE 436 R ++ Sbjct: 337 RPTFKQ 342 >3BEA-A nrPDB Length = 333 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 63/327 (19%), Positives = 120/327 (36%), Gaps = 37/327 (11%) Query: 132 KLLQKPCKELFSACAQSV--HEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQY 189 K QKP ++ +S + Y +P + E+ +N + Sbjct: 5 KYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYN-------------EKWEFPRNNLQFG 51 Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR---KGESMALNEKQILEKV-NSQF 245 + LG G FG+V GK A ++ K +K + ++E +I+ + + Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 111 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN------------PGFEEERALFYAA 293 +VNL A + ++ GDL + L +++ Sbjct: 112 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSS 171 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI---RGRVGTVG 350 ++ G+ L +N ++RD+ N+LL + +I D GLA I V Sbjct: 172 QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVK 231 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYS 409 +MAPE + + Y + D W G L++E+ G +P+ G K ++ + + + Sbjct: 232 WMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQ--P 289 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQE 436 + SI + + R Q+ Sbjct: 290 AFAPKNIYSIMQACWALEPTHRPTFQQ 316 >4AT3-A nrPDB Length = 299 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 102/274 (37%), Gaps = 28/274 (10%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQV-----RATGKMYACKRLEKKRIKKRKGESMALN 233 Q + ++ R LG+G FG+V + + A K L+ RK Sbjct: 8 QHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD---FHR 64 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP-----------G 282 E ++L + + +V D L +V M GDL + G Sbjct: 65 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE 124 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI 342 + + L A +I G+ L ++ V+RDL N L+ + ++I D G++ + D Sbjct: 125 LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYY 184 Query: 343 RGRVGT---VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKRE-EV 397 R T + +M PE + +++ D W LG +++E+ G+ P+ E Sbjct: 185 RVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT 244 Query: 398 DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQR 431 RVL+ E + ++ R Sbjct: 245 QGRVLQRPRTCPQ----EVYELMLGCWQREPHMR 274 >1U5R-A nrPDB Length = 348 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 103/273 (37%), Gaps = 15/273 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + + F R +G G FG V + ++ A K++ + + + E + L Sbjct: 49 KDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFL 108 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 +K+ + Y + LV+ G + + +E L G Sbjct: 109 QKLRHPNTIQYRGCYLREHTAWLVMEYCLGS--ASDLLEVHKKPLQEVEIAAVTHGALQG 166 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN 358 L LH N ++RD+K NILL + G +++ D G A + VGT +MAPEV+ Sbjct: 167 LAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVIL 223 Query: 359 ---NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 +Y D W LG E+ E + P + + E+ + S +SE Sbjct: 224 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPALQSGHWSEY 281 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 ++ L K + R + + +H F Sbjct: 282 FRNFVDSCLQKIPQDRPTSEV-----LLKHRFV 309 >1UA2-A nrPDB Length = 346 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 121/295 (41%), Gaps = 35/295 (11%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE--KKRIKKRKGESMALNEKQILEKV 241 + + LG+G F V + + T ++ A K+++ + K AL E ++L+++ Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + ++ L A+ K + LV M DL I + Y L GLE Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMET-DL-EVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVLNNQ 360 LH+ ++RDLKP N+LLD+ G ++++D GLA +V T Y APE+L Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 Query: 361 R-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV-LETEEVYSHKFS----- 413 R YG+ D W +GC++ E++ G + + + + TEE + S Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 Query: 414 ------------------EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 ++ + + L + R+ A + + +F N Sbjct: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT-----ATQALKMKYFSN 297 >3G0E-A nrPDB Length = 336 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 116/333 (34%), Gaps = 45/333 (13%) Query: 132 KLLQKPCKELFSACAQSVH--EYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQY 189 K LQKP E+ + ++ Y+ +P D +W++ +N Sbjct: 5 KYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYD-------HKWEF------PRNRLSFG 51 Query: 190 RVLGKGGFGEVCACQVRATGK-----MYACKRLEKKRIKKRKGESMALNEKQILEKV-NS 243 + LG G FG+V K A K L+ ++E ++L + N Sbjct: 52 KTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSA--HLTEREALMSELKVLSYLGNH 109 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF----------------EEER 287 +VNL A ++ GDL + + + E Sbjct: 110 MNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLED 169 Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR---G 344 L ++ ++ G+ L +N ++RDL NILL +I D GLA I Sbjct: 170 LLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGN 229 Query: 345 RVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLE 403 V +MAPE + N Y D W G ++E+ G SP+ G K ++ + Sbjct: 230 ARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFR 289 Query: 404 TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + E I K D +R ++ Sbjct: 290 M--LSPEHAPAEMYDIMKTCWDADPLKRPTFKQ 320 >2OGV-A nrPDB Length = 317 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 62/319 (19%), Positives = 119/319 (37%), Gaps = 33/319 (10%) Query: 136 KPCKELFSACAQSV--HEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLG 193 KP ++ +S + Y +P + E+ +N + + LG Sbjct: 1 KPKYQVRWKIIESYEGNSYTFIDPTQLPYN-------------EKWEFPRNNLQFGKTLG 47 Query: 194 KGGFGEVCACQVRATGKMYACKRLEKKRIKKR---KGESMALNEKQILEKV-NSQFVVNL 249 G FG+V GK A ++ K +K + ++E +I+ + + +VNL Sbjct: 48 AGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNL 107 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGN--------PGFEEERALFYAAEILCGLED 301 A + ++ GDL + E L +++++ G+ Sbjct: 108 LGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAF 167 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI---RGRVGTVGYMAPEVLN 358 L +N ++RD+ N+LL + +I D GLA I V +MAPE + Sbjct: 168 LASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIF 227 Query: 359 NQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 + Y + D W G L++E+ G +P+ G K ++ + + + + Sbjct: 228 DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQ--PAFAPKNIY 285 Query: 418 SICKMLLTKDAKQRLGCQE 436 SI + + R Q+ Sbjct: 286 SIMQACWALEPTHRPTFQQ 304 >4XLV-A nrPDB Length = 328 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 124/298 (41%), Gaps = 29/298 (9%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCA--CQVRATGK---MYACKRLEKKRIKKRKGESMA 231 + V++ R LG+G FG V + G+ A K + + + + E Sbjct: 32 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIE--F 89 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY--------NMGNPGF 283 LNE +++ VV L +V+ +M GDLK ++ N G P Sbjct: 90 LNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPP 149 Query: 284 EEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR 343 + + AAEI G+ L+ + V+RDL N ++ ++I D G+ I E D R Sbjct: 150 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYR 209 Query: 344 -GRVG--TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG-RKEKVKREEVD 398 G G V +MAPE L + + S D W G +++E+ + P++G E+V + +D Sbjct: 210 KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD 269 Query: 399 RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKR---HPFFRNMNF 453 L+ + + + + +M + R E + + HP F ++F Sbjct: 270 GGYLDQPDNCPERVT----DLMRMCWQFNPNMRPTFLE--IVNLLKDDLHPSFPEVSF 321 >2GCD-A nrPDB Length = 309 Score = 245 bits (625), Expect = 5e-65, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 103/273 (37%), Gaps = 15/273 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + + F R +G G FG V + ++ A K++ + + + E + L Sbjct: 10 KDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFL 69 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 +K+ + Y + LV+ G + + +E L G Sbjct: 70 QKLRHPNTIQYRGCYLREHTAWLVMEYCLGS--ASDLLEVHKKPLQEVEIAAVTHGALQG 127 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN 358 L LH N ++RD+K NILL + G +++ D G A + VGT +MAPEV+ Sbjct: 128 LAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVIL 184 Query: 359 ---NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 +Y D W LG E+ E + P + + E+ + S +SE Sbjct: 185 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPALQSGHWSEY 242 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 ++ L K + R + + +H F Sbjct: 243 FRNFVDSCLQKIPQDRPTSEV-----LLKHRFV 270 >2W96-B nrPDB Length = 306 Score = 245 bits (625), Expect = 5e-65, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 110/295 (37%), Gaps = 38/295 (12%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN-- 242 + +G G +G V + +G A K + + + E +L ++ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGE-EGLPISTVREVALLRRLEAF 63 Query: 243 -SQFVVNLAYAYETKD-----ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 VV L T + LV ++ DL+ ++ PG E + L Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 GL+ LH V+RDLKPENIL+ G ++++D GLA + V T+ Y APEV Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV-LETEEVYSHKFS-- 413 L Y D W +GC+ EM + F G E + ++ + L E+ + S Sbjct: 183 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 242 Query: 414 --------------------EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 E + +LT + +R+ A +H + Sbjct: 243 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL 292 >4R7H-A nrPDB Length = 343 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 120/336 (35%), Gaps = 46/336 (13%) Query: 134 LQKPCKELFSACAQSV--HEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRV 191 QKP ++ +S + Y +P + E+ +N + + Sbjct: 11 GQKPKYQVRWKIIESYEGNSYTFIDPTQLPYN-------------EKWEFPRNNLQFGKT 57 Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR---KGESMALNEKQILEKV-NSQFVV 247 LG G FG+V GK A ++ K +K + ++E +I+ + + +V Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 117 Query: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN---------------------PGFEEE 286 NL A + ++ GDL + E Sbjct: 118 NLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELR 177 Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI---R 343 L +++++ G+ L +N ++RD+ N+LL + +I D GLA I Sbjct: 178 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 237 Query: 344 GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVL 402 V +MAPE + + Y + D W G L++E+ G +P+ G K ++ + Sbjct: 238 NARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGY 297 Query: 403 ETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEG 438 + + + SI + + R Q+ Sbjct: 298 QMAQ--PAFAPKNIYSIMQACWALEPTHRPTFQQIT 331 >5Z33-A nrPDB Length = 425 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 75/351 (21%), Positives = 131/351 (37%), Gaps = 56/351 (15%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + + + LG+G +G VCA T + A K++ K+ AL E ++L+ Sbjct: 28 IVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV-TNVFSKKILAKRALREIKLLQH 86 Query: 241 VN-SQFVVNLAYA----YETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 + + L + + L +M DL I + + + +I Sbjct: 87 FRGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRS--GQPLTDAHFQSFIYQI 143 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-----EGDLIRGRVGTVG 350 LCGL+ +H N ++RDLKP N+L++ ++I D GLA + V T Sbjct: 144 LCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRW 203 Query: 351 YMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRK-----------EKVKREEVD 398 Y APE+ L+ Q Y + D W +GC++ E++ G+ F+GR EE Sbjct: 204 YRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETL 263 Query: 399 RRV-------------LETEEVYSHKFS---EEAKSICKMLLTKDAKQRLGCQEEGAAEV 442 R+ ++ + F +A + +L D R+ + Sbjct: 264 SRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRIS-----VEQA 318 Query: 443 KRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDH 493 HP+ D PD + D +E ++ + LD Sbjct: 319 LEHPYL---------HIWHDASDEPDCPTTFNFDFEVVEDVGEMRKMILDE 360 >4U41-A nrPDB Length = 332 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 67/278 (24%), Positives = 116/278 (41%), Gaps = 24/278 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ- 244 F V+G G +G+V + TG++ A K ++ E E +L+K + Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE----DEEEEIKLEINMLKKYSHHR 81 Query: 245 FVVNLAYAYETK------DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + A+ K D L LV+ G + + N +E+ + + EIL G Sbjct: 82 NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 141 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRVGTVGYMAPEVL 357 L LH + ++RD+K +N+LL + +++ D G++ ++ +GT +MAPEV+ Sbjct: 142 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 201 Query: 358 N-----NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 + Y D W G EM EG P + R + S K+ Sbjct: 202 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSKKW 259 Query: 413 SEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 S++ S + L K+ QR ++ +HPF R+ Sbjct: 260 SKKFFSFIEGCLVKNYMQR-----PSTEQLLKHPFIRD 292 >3A4O-X nrPDB Length = 286 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 112/262 (42%), Gaps = 13/262 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + + + + + + LG G FGEV + K A K L+ + L E Sbjct: 6 DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMS----VQAFLEEAN 60 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +++ + +V L ++ + ++ M G L + + + + ++A+I Sbjct: 61 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 120 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGYMA 353 G+ + R+N ++RDL+ N+L+ + +I+D GLA I + + R G + + A Sbjct: 121 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNE-YTAREGAKFPIKWTA 179 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 PE +N + + D W G L+YE++ G+ P+ GR + + V Sbjct: 180 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQG-YRMPRV--ENC 236 Query: 413 SEEAKSICKMLLTKDAKQRLGC 434 +E I KM + A++R Sbjct: 237 PDELYDIMKMCWKEKAEERPTF 258 >6CCF-A nrPDB Length = 290 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 78/296 (26%), Positives = 131/296 (44%), Gaps = 43/296 (14%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGE--------------- 228 N ++ +GKG +G V + + YA K L KK++ K+ G Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 229 --------SMALNEKQILEKVNSQFVVNLAYAYET--KDALCLVLTIMNGGDLKFHIYNM 278 E IL+K++ VV L + +D L LV ++ G + Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV---P 121 Query: 279 GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE 338 + F EE+A Y +++ GLE LH + V+RD+KP N+LL D GH++I+D G++ + Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 181 Query: 339 GD-LIRGRVGTVGYMAPEVLNNQRY---GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKR 394 D + GT +MAPE +++ G + D W G +Y + G+ PF Sbjct: 182 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH 241 Query: 395 EEVDRRVLETEEVYS--HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 R++ V+ + SEE K + +L K+ + R+G ++K HP+ Sbjct: 242 ----RKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIG-----VPDIKLHPWV 288 >4IC8-A nrPDB Length = 442 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 71/324 (21%), Positives = 126/324 (38%), Gaps = 51/324 (15%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + +G G +G V + + R TG+ A K++ L E +IL+ Sbjct: 53 VGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP-NAFDVVTNAKRTLRELKILKHF 111 Query: 242 NSQFVVNLAYA------YETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 ++ + Y ++ +VL +M DL I++ + E ++ ++ Sbjct: 112 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHS--SQPLTLEHVRYFLYQL 168 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-----PEGDLIRGRVGTVG 350 L GL+ +H ++RDLKP N+L+++ ++I D G+A + + V T Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 351 YMAPE-VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV-- 407 Y APE +L+ Y + D W +GC+ EM+ + F G K V + ++ VL T Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPG-KNYVHQLQLIMMVLGTPSPAV 287 Query: 408 -----------YSHKFSE---------------EAKSICKMLLTKDAKQRLGCQEEGAAE 441 Y +A S+ +L + R+ AA Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARIS-----AAA 342 Query: 442 VKRHPFFRNMNFKRLEAGMLDPPF 465 RHPF + + PPF Sbjct: 343 ALRHPFLAKYH-DPDDEPDCAPPF 365 >4ZSG-A nrPDB Length = 347 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 71/324 (21%), Positives = 126/324 (38%), Gaps = 51/324 (15%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + +G G +G V + + R TG+ A K++ L E +IL+ Sbjct: 5 VGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP-NAFDVVTNAKRTLRELKILKHF 63 Query: 242 NSQFVVNLAYA------YETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 ++ + Y ++ +VL +M DL I++ + E ++ ++ Sbjct: 64 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHS--SQPLTLEHVRYFLYQL 120 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-----PEGDLIRGRVGTVG 350 L GL+ +H ++RDLKP N+L+++ ++I D G+A + + V T Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 351 YMAPE-VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV-- 407 Y APE +L+ Y + D W +GC+ EM+ + F G K V + ++ VL T Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPG-KNYVHQLQLIMMVLGTPSPAV 239 Query: 408 -----------YSHKFSE---------------EAKSICKMLLTKDAKQRLGCQEEGAAE 441 Y +A S+ +L + R+ AA Sbjct: 240 IQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARIS-----AAA 294 Query: 442 VKRHPFFRNMNFKRLEAGMLDPPF 465 RHPF + + PPF Sbjct: 295 ALRHPFLAKYH-DPDDEPDCAPPF 317 >2J0K-A nrPDB Length = 656 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 52/294 (17%), Positives = 109/294 (37%), Gaps = 15/294 (5%) Query: 153 LRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG--- 209 + +Y + + + + + R +G+G FG+V + Sbjct: 359 VSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPA 418 Query: 210 KMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGG 269 A K + L E + + + +V L T++ + +++ + G Sbjct: 419 MAVAIKTCKNCT--SDSVREKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLG 475 Query: 270 DLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISD 329 +L+ + + + + YA ++ L L + V+RD+ N+L+ +++ D Sbjct: 476 ELRSFL-QVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGD 534 Query: 330 LGLAVKIPEGDLIRGRVG--TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFR 386 GL+ + + + G + +MAPE +N +R+ + D W G ++E++ G PF+ Sbjct: 535 FGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQ 594 Query: 387 GRKEKVKREEVDRRVLETEE-VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGA 439 G K V R+ E S+ D +R E A Sbjct: 595 GVKNND----VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKA 644 >6CQF-A nrPDB Length = 297 Score = 241 bits (616), Expect = 6e-64, Method: Composition-based stats. Identities = 64/270 (23%), Positives = 113/270 (41%), Gaps = 10/270 (3%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 ++ + + LG G +GEV + + +G + A K ++ ++ S E IL+ Sbjct: 14 PRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK---MEPDDDVSTLQKEILILKTC 70 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 +V +Y L + + G L+ G E + + E+L GL Sbjct: 71 RHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG--SLSELQISYVCREVLQGLAY 128 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR-GRVGTVGYMAPE---VL 357 LH + ++RD+K NIL++D G +R++D G++ +I R +GT +MAPE V Sbjct: 129 LHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVA 188 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH-KFSEEA 416 Y D W LG E+ E Q P + + + + K+S Sbjct: 189 LKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAF 248 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHP 446 + K+ LTK K+R + + ++ P Sbjct: 249 HNFIKVTLTKSPKKRPSATKMLSHQLVSQP 278 >3MIA-A nrPDB Length = 351 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 117/306 (38%), Gaps = 50/306 (16%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + + +G+G FGEV + R TG+ A K++ + +K AL E +IL+ + + Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHE 76 Query: 245 FVVNLAYAYETK--------DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 VVNL TK ++ LV DL + N+ F +L Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNV-LVKFTLSEIKRVMQMLL 134 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-----PEGDLIRGRVGTVGY 351 GL +HR ++RD+K N+L+ G ++++D GLA + + RV T+ Y Sbjct: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Query: 352 MAPEVLNNQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 PE+L +R YG D WG GC++ EM +G E+ + + + Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 Query: 411 KF----------------------------SEEAKSICKMLLTKDAKQRLGCQEEGAAEV 442 A + LL D QR+ + + Sbjct: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDDA 309 Query: 443 KRHPFF 448 H FF Sbjct: 310 LNHDFF 315 >3OZ6-A nrPDB Length = 388 Score = 241 bits (614), Expect = 9e-64, Method: Composition-based stats. Identities = 67/335 (20%), Positives = 116/335 (34%), Gaps = 79/335 (23%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-N 242 + + LGKG +G V R TG++ A K++ + E IL ++ Sbjct: 9 RKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIF-DAFQNSTDAQRTFREIMILTELSG 67 Query: 243 SQFVVNLAYAY--ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + +VNL + + LV M DL I E + +++ ++ Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVIRAN---ILEPVHKQYVVYQLIKVIK 123 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI----------------------PE 338 LH ++RD+KP NILL+ H++++D GL+ + Sbjct: 124 YLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDD 183 Query: 339 GDLIRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE-- 395 ++ V T Y APE+L +Y D W LGC++ E++ G+ F G + E Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERI 243 Query: 396 -------------------------------EVDRRVLETEEVYSHKF----------SE 414 E+ + +E Sbjct: 244 IGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNE 303 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 EA + LL + +R+ A + +HPF Sbjct: 304 EALDLLDKLLQFNPNKRIS-----ANDALKHPFVS 333 >3GQL-A nrPDB Length = 326 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 59/285 (20%), Positives = 117/285 (41%), Gaps = 31/285 (10%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKRLEKKRIKKRKGESM 230 R + ++ + LG+G FG+V + K A K L+ +K S Sbjct: 22 RWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK--DLSD 79 Query: 231 ALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF------ 283 ++E ++++ + + ++NL A L +++ + G+L+ ++ PG Sbjct: 80 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 139 Query: 284 ---EEERA-----LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 EE+ + A ++ G+E L + ++RDL N+L+ + ++I+D GLA Sbjct: 140 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 199 Query: 336 IPEGDLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEK 391 I D + V +MAPE L ++ Y D W G L++E+ G SP+ G + Sbjct: 200 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 259 Query: 392 VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + + + + E + + QR ++ Sbjct: 260 ELFKLLKEGHRMDK---PSNCTNELYMMMRDCWHAVPSQRPTFKQ 301 >4E93-A nrPDB Length = 377 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 58/262 (22%), Positives = 106/262 (40%), Gaps = 10/262 (3%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 ++ + +G+G FGEV + ++RA + A K + ++ L E + Sbjct: 107 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK--SCRETLPPDLKAKFLQEAR 164 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 IL++ + +V L K + +V+ ++ GGD + G + L + Sbjct: 165 ILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQMVGDAA 223 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG---RVGTVGYMA 353 G+E L + ++RDL N L+ + ++ISD G++ + +G R V + A Sbjct: 224 AGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTA 283 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 PE LN RY D W G L++E G SP+ + RE V++ Sbjct: 284 PEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG---GRLPCPELC 340 Query: 413 SEEAKSICKMLLTKDAKQRLGC 434 + + + + QR Sbjct: 341 PDAVFRLMEQCWAYEPGQRPSF 362 >2XNP-A nrPDB Length = 279 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 63/275 (22%), Positives = 112/275 (40%), Gaps = 19/275 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + +G G +G + ++ GK+ K L+ + + M ++E +L ++ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMT-EAEKQMLVSEVNLLRELKH 64 Query: 244 QFVVNLAYAYETKDA--LCLVLTIMNGGDLKFHIYN--MGNPGFEEERALFYAAEILCGL 299 +V + L +V+ GGDL I +EE L ++ L Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 300 EDLHREN-----TVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMA 353 ++ HR + ++RDLKP N+ LD ++++ D GLA + + + VGT YM+ Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMS 184 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 PE +N Y D W LGCL+YE+ PF +K ++ +++S Sbjct: 185 PEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFR---RIPYRYS 241 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 +E I +L R E+ +P Sbjct: 242 DELNEIITRMLNLKDYHR-----PSVEEILENPLI 271 >4QTB-A nrPDB Length = 380 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 64/319 (20%), Positives = 125/319 (39%), Gaps = 51/319 (15%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + Q + +G+G +G V + A K++ + + L E QIL + + Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHE 99 Query: 245 FVVNLAYAY-----ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 V+ + E + +V +M DL + + + ++ +IL GL Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKS---QQLSNDHICYFLYQILRGL 155 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV----KIPEGDLIRGRVGTVGYMAPE 355 + +H N ++RDLKP N+L++ ++I D GLA + + V T Y APE Sbjct: 156 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 215 Query: 356 V-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEV----------------- 397 + LN++ Y S D W +GC++ EM+ + F G+ + + Sbjct: 216 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 275 Query: 398 -----------DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHP 446 + + +++ S+ A + +LT + +R+ E HP Sbjct: 276 MKARNYLQSLPSKTKVAWAKLFPKSDSK-ALDLLDRMLTFNPNKRIT-----VEEALAHP 329 Query: 447 FFRNMNFKRLEAGMLDPPF 465 + + + + + PF Sbjct: 330 YLEQY-YDPTDEPVAEEPF 347 >4E7W-A nrPDB Length = 394 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 75/322 (23%), Positives = 122/322 (37%), Gaps = 61/322 (18%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKR-LEKKRIKKRKGESMALNEKQILEKVNSQ 244 + +V+G G FG V ++ + + A K+ L+ KR K E QI+ V Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN--------RELQIMRIVKHP 92 Query: 245 FVVNLAYAYETKDA------LCLVLTIMNGGDLKFHIYNMGN------PGFEEERALFYA 292 VV+L + + L LVL + +Y Y Sbjct: 93 NVVDLKAFFYSNGDKKDEVFLNLVLEYVP-----ETVYRASRHYAKLKQTMPMLLIKLYM 147 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGY 351 ++L L +H +RD+KP+N+LLD G +++ D G A + G+ + + Y Sbjct: 148 YQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYY 207 Query: 352 MAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRK-----------------EKVK 393 APE++ Y + D W GC++ E+++GQ F G E++K Sbjct: 208 RAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIK 267 Query: 394 REEVDRRVLETEEVYSHKFS--------EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRH 445 + + ++ H FS +A + LL RL A E H Sbjct: 268 TMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLT-----AIEALCH 322 Query: 446 PFFRNMNF--KRLEAGMLDPPF 465 PFF + R+ G PP Sbjct: 323 PFFDELRTGEARMPNGRELPPL 344 >3GC0-A nrPDB Length = 329 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 117/304 (38%), Gaps = 42/304 (13%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + +R+ LG+G +GEV T + A KR+ + ++ A+ E +L+++ Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEH-EEEGVPGTAIREVSLLKELQH 92 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + ++ L L L+ DLK ++ NP + +++ G+ H Sbjct: 93 RNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDK--NPDVSMRVIKSFLYQLINGVNFCH 149 Query: 304 RENTVYRDLKPENILL-----DDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVL 357 ++RDLKP+N+LL + ++I D GLA + T+ Y PE+L Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209 Query: 358 NN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR--------------RVL 402 + Y S D W + C+ EM+ F G E + ++ + Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALP 269 Query: 403 ETEEVYSHKFSEEAKSIC------------KMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + ++ + + K + +L D +R+ A HP+F + Sbjct: 270 DWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRIS-----AKNALEHPYFSH 324 Query: 451 MNFK 454 +F Sbjct: 325 NDFD 328 >3QUP-A nrPDB Length = 323 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 119/303 (39%), Gaps = 24/303 (7%) Query: 162 LDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG---KMYACKRLE 218 LDS+ L+ K LE + + F R+LGKG FG V Q++ A K L+ Sbjct: 2 LDSLGISDELKEK-LEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLK 60 Query: 219 KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYET---KDAL---CLVLTIMNGGDLK 272 I E L E +++ + V L K L ++L M GDL Sbjct: 61 ADIIASSDIEE-FLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLH 119 Query: 273 FHIYNMG----NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRIS 328 + + + + +I CG+E L N ++RDL N +L + + ++ Sbjct: 120 AFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVA 179 Query: 329 DLGLAVKIPEGDLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSP 384 D GL+ KI GD R V ++A E L + Y + D W G ++E++ GQ+P Sbjct: 180 DFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTP 239 Query: 385 FRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQR--LGCQEEGAAEV 442 + G + E + + + EE + + D KQR C + Sbjct: 240 YAGIENA---EIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENI 296 Query: 443 KRH 445 H Sbjct: 297 LGH 299 >4XUF-A nrPDB Length = 297 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 113/293 (38%), Gaps = 37/293 (12%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-----MYACKRLEKKRIKKRKGESMAL 232 + + +VLG G FG+V K A K L++K + + Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALM 60 Query: 233 NEKQILEKVN-SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA--- 288 +E +++ ++ + +VNL A + L+ GDL ++ + F E+ Sbjct: 61 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRS-KREKFSEDEIEYE 119 Query: 289 -------------------LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISD 329 L +A ++ G+E L ++ V+RDL N+L+ ++I D Sbjct: 120 NQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICD 179 Query: 330 LGLAVKIPEGDLIRGR---VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPF 385 GLA I R V +MAPE L Y + D W G L++E+ G +P+ Sbjct: 180 FGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 239 Query: 386 RGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEG 438 G ++ + + ++ + +EE I + D+++R Sbjct: 240 PGIPVDANFYKLIQNGFKMDQPFYA--TEEIYIIMQSCWAFDSRKRPSFPNLT 290 >5NGU-A nrPDB Length = 381 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 62/320 (19%), Positives = 122/320 (38%), Gaps = 51/320 (15%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + +G+G +G VC+ A K++ + + L E +IL + + Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS--PFEHQTYCQRTLREIKILLRFRHE 100 Query: 245 FVVNLAYAY-----ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 ++ + E + +V +M DL + + ++ +IL GL Sbjct: 101 NIIGINDIIRAPTIEQMKDVYIVQDLMET-DLYKLLK---TQHLSNDHICYFLYQILRGL 156 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD----LIRGRVGTVGYMAPE 355 + +H N ++RDLKP N+LL+ ++I D GLA + V T Y APE Sbjct: 157 KYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPE 216 Query: 356 V-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD---------------- 398 + LN++ Y S D W +GC++ EM+ + F G+ + + Sbjct: 217 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 276 Query: 399 ------------RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHP 446 + + ++ + S+ A + +LT + +R+ + HP Sbjct: 277 LKARNYLLSLPHKNKVPWNRLFPNADSK-ALDLLDKMLTFNPHKRI-----EVEQALAHP 330 Query: 447 FFRNMNFKRLEAGMLDPPFV 466 + + + + + PF Sbjct: 331 YLEQY-YDPSDEPIAEAPFK 349 >4GS6-A nrPDB Length = 315 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 108/270 (40%), Gaps = 19/270 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + V+G+G FG VC + RA K A K++ + + E + L + Sbjct: 6 IDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI-----ESESERKAFIVELRQLSR 58 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN-PGFEEERALFYAAEILCGL 299 VN +V L A + +CLV+ GG L ++ P + A+ + + G+ Sbjct: 59 VNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 116 Query: 300 EDLHREN---TVYRDLKPENILLDDYGHI-RISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 LH ++RDLKP N+LL G + +I D G A I + G+ +MAPE Sbjct: 117 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH--MTNNKGSAAWMAPE 174 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 V Y D + G +++E+I + PF + T + Sbjct: 175 VFEGSNYSEKCDVFSWGIILWEVITRRKPF-DEIGGPAFRIMWAVHNGTRPPLIKNLPKP 233 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRH 445 +S+ +KD QR +E ++ H Sbjct: 234 IESLMTRCWSKDPSQRPSMEE--IVKIMTH 261 >5A46-A nrPDB Length = 386 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 59/285 (20%), Positives = 117/285 (41%), Gaps = 31/285 (10%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKRLEKKRIKKRKGESM 230 R + ++ + LG+G FG+V + K A K L+ +K S Sbjct: 34 RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK--DLSD 91 Query: 231 ALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF------ 283 ++E ++++ + + ++NL A L +++ + G+L+ ++ PG Sbjct: 92 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 151 Query: 284 ---EEERA-----LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 EE+ + A ++ G+E L + ++RDL N+L+ + ++I+D GLA Sbjct: 152 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 211 Query: 336 IPEGDLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEK 391 I D + V +MAPE L ++ Y D W G L++E+ G SP+ G + Sbjct: 212 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 271 Query: 392 VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + + + + E + + QR ++ Sbjct: 272 ELFKLLKEGHRMDK---PSNCTNELYMMMRDCWHAVPSQRPTFKQ 313 >6E4F-A nrPDB Length = 290 Score = 238 bits (608), Expect = 5e-63, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 118/278 (42%), Gaps = 17/278 (6%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F + + + LG G FG V + R A K +++ + Sbjct: 11 ENLYFQGTAGLGY-GSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSM 68 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 E + E +++ ++ + +V L + + ++ M G L ++ M + Sbjct: 69 S----EDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR- 123 Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI 342 F+ ++ L ++ +E L + ++RDL N L++D G +++SD GL+ + + D Sbjct: 124 FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLD-DEY 182 Query: 343 RGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVD 398 VG V + PEVL ++ D W G L++E+ G+ P+ E+ E Sbjct: 183 TSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPY----ERFTNSETA 238 Query: 399 RRVLETEEVY-SHKFSEEAKSICKMLLTKDAKQRLGCQ 435 + + +Y H SE+ +I + A +R + Sbjct: 239 EHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFK 276 >5AIR-A nrPDB Length = 430 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 80/363 (22%), Positives = 143/363 (39%), Gaps = 75/363 (20%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKR-LEKKRIKKRKGESMALNEKQILEKVNS 243 ++ +V+G G FG V ++ +G++ A K+ L+ KR K E QI+ K++ Sbjct: 65 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDH 116 Query: 244 QFVVNLAYAY----ETKDALCL--VLTIMNGGDLKFHI---YNMGNPGFEEERALFYAAE 294 +V L Y + E KD + L VL + + + + Y+ Y + Sbjct: 117 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQ 174 Query: 295 ILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMA 353 + L +H +RD+KP+N+LLD D +++ D G A ++ G+ + + Y A Sbjct: 175 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 234 Query: 354 PEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV----------- 401 PE++ Y S D W GC++ E++ GQ F G + E+ + + Sbjct: 235 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 294 Query: 402 ------LETEEVYSHKFS--------EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 + ++ +H ++ EA ++C LL RL E A H F Sbjct: 295 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA-----HSF 349 Query: 448 FRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSV 507 F L P+ + +D + F+T + S ++ Sbjct: 350 F-----DELRD--------PNVKLPNGRDTPALFNFTT----------QELSSNPPLATI 386 Query: 508 SIP 510 IP Sbjct: 387 LIP 389 >4RC3-A nrPDB Length = 289 Score = 238 bits (607), Expect = 6e-63, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 130/306 (42%), Gaps = 26/306 (8%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN 233 ++ + ++ ++ +LG GGFG V + + A K +EK RI Sbjct: 2 PHMKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 61 Query: 234 ---EKQILEKVNSQF--VVNLAYAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEER 287 E +L+KV+S F V+ L +E D+ L+L DL I G +EE Sbjct: 62 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEEL 119 Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRV 346 A + ++L + H ++RD+K ENIL+D + G +++ D G + + + + Sbjct: 120 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFD 178 Query: 347 GTVGYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE 405 GT Y PE + RY G S W LG L+Y+M+ G PF E D ++ + Sbjct: 179 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----------EHDEEIIRGQ 228 Query: 406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPF 465 + + S E + + + L R E++ HP+ +++ + A + Sbjct: 229 VFFRQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDVLLPQETAEIHLHSL 283 Query: 466 VPDPRA 471 P P Sbjct: 284 SPGPSK 289 >3BGP-A nrPDB Length = 333 Score = 237 bits (606), Expect = 8e-63, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 129/303 (42%), Gaps = 26/303 (8%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN--- 233 + + ++ ++ +LG GGFG V + + A K +EK RI Sbjct: 49 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 108 Query: 234 EKQILEKVNSQF--VVNLAYAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALF 290 E +L+KV+S F V+ L +E D+ L+L DL I G +EE A Sbjct: 109 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARS 166 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTV 349 + ++L + H ++RD+K ENIL+D + G +++ D G + + + + GT Sbjct: 167 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTR 225 Query: 350 GYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY 408 Y PE + RY G S W LG L+Y+M+ G PF E D ++ + + Sbjct: 226 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----------EHDEEIIRGQVFF 275 Query: 409 SHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPD 468 + S E + + + L R E++ HP+ +++ + A + P Sbjct: 276 RQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDVLLPQETAEIHLHSLSPG 330 Query: 469 PRA 471 P Sbjct: 331 PSK 333 >1JPA-A nrPDB Length = 312 Score = 237 bits (605), Expect = 1e-62, Method: Composition-based stats. Identities = 56/301 (18%), Positives = 120/301 (39%), Gaps = 18/301 (5%) Query: 158 FHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM---YAC 214 ++D F+ + + + + + +V+G G FGEVC+ ++ GK A Sbjct: 7 MKIFIDPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAI 66 Query: 215 KRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH 274 K L+ +K++ + L+E I+ + + V++L + ++ M G L Sbjct: 67 KTLKSGYTEKQRRD--FLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSF 124 Query: 275 IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV 334 + F + + I G++ L N V+RDL NIL++ ++SD GL+ Sbjct: 125 LRQNDGQ-FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSR 183 Query: 335 KIPEGD---LIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG 387 + + +G + + APE + +++ + D W G +++E++ G+ P+ Sbjct: 184 FLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWD 243 Query: 388 RKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQR--LGCQEEGAAEVKRH 445 + +++ + + KD R G ++ R+ Sbjct: 244 MTNQDVINAIEQ---DYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRN 300 Query: 446 P 446 P Sbjct: 301 P 301 >1K9A-A nrPDB Length = 450 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 60/282 (21%), Positives = 105/282 (37%), Gaps = 20/282 (7%) Query: 168 DRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG 227 D F + W + + + +GKG FG+V R G A K + K Sbjct: 181 DEFYRSGW----ALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI-----KNDAT 229 Query: 228 ESMALNEKQILEKVNSQFVVNLAYAY-ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286 L E ++ ++ +V L E K L +V M G L ++ + G + Sbjct: 230 AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV 346 L ++ ++ +E L N V+RDL N+L+ + ++SD GL + Sbjct: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL- 348 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETE 405 V + APE L +++ D W G L++E+ G+ P+ ++ V R + Sbjct: 349 -PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP---RIPLKDVVPRVEKGYK 404 Query: 406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQE--EGAAEVKRH 445 + K DA R + E ++ H Sbjct: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTH 446 >2BRG-A nrPDB Length = 297 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 65/268 (24%), Positives = 117/268 (43%), Gaps = 14/268 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + + LG+G +GEV R T + A K ++ KR E I + +N Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR--AVDCPENIKKEICINKMLNH 64 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + VV + L L +GG+L I + G E A + +++ G+ LH Sbjct: 65 ENVVKFYGHRREGNIQYLFLEYCSGGELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---LIRGRVGTVGYMAPEVLNNQ 360 +RD+KPEN+LLD+ +++ISD GLA + L+ GT+ Y+APE+L + Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 361 RY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 + D W G ++ M+ G+ P+ + +E D + +T K ++ Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPW-DQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLAL 241 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 +L ++ R+ ++K+ + Sbjct: 242 LHKILVENPSARITI-----PDIKKDRW 264 >2HK5-A nrPDB Length = 270 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 108/267 (40%), Gaps = 15/267 (5%) Query: 173 WKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMAL 232 W+ + + + + + + LG G FGEV A K ++ + L Sbjct: 5 WE-KDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS----VEAFL 58 Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 E +++ + +V L A TK+ + ++ M G L + + + + ++ Sbjct: 59 AEANVMKTLQHDKLVKLH-AVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFS 117 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TV 349 A+I G+ + + N ++RDL+ NIL+ +I+D GLA I + + R G + Sbjct: 118 AQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE-YTAREGAKFPI 176 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVY 408 + APE +N + + D W G L+ E++ G+ P+ G ++R Sbjct: 177 KWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERG-YRMPR-- 233 Query: 409 SHKFSEEAKSICKMLLTKDAKQRLGCQ 435 EE +I ++R + Sbjct: 234 PENCPEELYNIMMRCWKNRPEERPTFE 260 >1S9I-A nrPDB Length = 354 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 118/315 (37%), Gaps = 55/315 (17%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 + + F + LG G G V Q R +G + A K + + K + + E Q+L Sbjct: 12 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE--IKPAIRNQIIRELQVLH 69 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + NS ++V A+ + + + + M+GG L + EE + +L GL Sbjct: 70 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKR--IPEEILGKVSIAVLRGL 127 Query: 300 EDLHREN-TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN 358 L ++ ++RD+KP NIL++ G I++ D G++ ++ + + VGT YMAPE L Sbjct: 128 AYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMAPERLQ 186 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS----- 413 Y + D W +G + E+ G+ P K R V++ EE H S Sbjct: 187 GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP 246 Query: 414 ---------------------------------------EEAKSICKMLLTKDAKQRLGC 434 + + L K+ +R Sbjct: 247 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL 306 Query: 435 QEEGAAEVKRHPFFR 449 + H F + Sbjct: 307 KMLT-----NHTFIK 316 >5TUR-A nrPDB Length = 404 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 129/303 (42%), Gaps = 26/303 (8%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN--- 233 + + ++ ++ +LG GGFG V + + A K +EK RI Sbjct: 120 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 179 Query: 234 EKQILEKVNSQF--VVNLAYAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALF 290 E +L+KV+S F V+ L +E D+ L+L DL I G +EE A Sbjct: 180 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARS 237 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTV 349 + ++L + H ++RD+K ENIL+D + G +++ D G + + + + GT Sbjct: 238 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTR 296 Query: 350 GYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY 408 Y PE + RY G S W LG L+Y+M+ G PF E D ++ + + Sbjct: 297 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----------EHDEEIIRGQVFF 346 Query: 409 SHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPD 468 + S E + + + L R E++ HP+ +++ + A + P Sbjct: 347 RQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDVLLPQETAEIHLHSLSPG 401 Query: 469 PRA 471 P Sbjct: 402 PSK 404 >3ALO-A nrPDB Length = 327 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 58/281 (20%), Positives = 119/281 (42%), Gaps = 15/281 (5%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + T + +G+G +G V + +G++ A KR+ + + +++ + + ++ Sbjct: 15 QHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQLLMDLDV 73 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGG--DLKFHIYNMGNPGFEEERALFYAAE 294 ++ + ++V A + + + +M+ ++Y++ + EE Sbjct: 74 VMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLA 133 Query: 295 ILCGLEDL-HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMA 353 + L L ++RD+KP NILLD G+I++ D G++ ++ + G YMA Sbjct: 134 TVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMA 193 Query: 354 PEVL----NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE--KVKREEVDRRVLETEEV 407 PE + + Q Y + D W LG +YE+ G+ P+ + V + Sbjct: 194 PERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNS 253 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 +FS + + LTKD +R E+ +HPF Sbjct: 254 EEREFSPSFINFVNLCLTKDESKR-----PKYKELLKHPFI 289 >4H1J-A nrPDB Length = 293 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 50/261 (19%), Positives = 104/261 (39%), Gaps = 13/261 (4%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQ---VRATGKMYACKRLEKKRIKKRKGESMALNE 234 + + + R+LG+G FGEV + A K +K K ++E Sbjct: 18 QYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK--EKFMSE 75 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 I++ ++ +V L E + +++ + G+L ++ N + + Y+ + Sbjct: 76 AVIMKNLDHPHIVKLIGIIEE-EPTWIIMELYPYGELGHYLERNKN-SLKVLTLVLYSLQ 133 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG--TVGYM 352 I + L N V+RD+ NIL+ +++ D GL+ I + D + V + +M Sbjct: 134 ICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWM 193 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 +PE +N +R+ + D W ++E++ G+ PF + K +++ Sbjct: 194 SPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKG---DRLPKPDL 250 Query: 412 FSEEAKSICKMLLTKDAKQRL 432 ++ D R Sbjct: 251 CPPVLYTLMTRCWDYDPSDRP 271 >5VO2-A nrPDB Length = 300 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 47/269 (17%), Positives = 94/269 (34%), Gaps = 21/269 (7%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + V + +G G G V + G+ A K++ + + Sbjct: 5 DLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD----------IK 52 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 L K+ ++ C+++ G L + + ++ I Sbjct: 53 HLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR--AGRPVTPSLLVDWSMGIA 110 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 G+ LH ++RDLK N+L+ ++ISD G + ++ + GTV +MAPEV Sbjct: 111 GGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEV 170 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 + N+ D W G +++E++ G+ P++ V L + Sbjct: 171 IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV--PSSCPDGF 228 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRH 445 K + + + R ++ H Sbjct: 229 KILLRQCWNSKPRNR-----PSFRQILLH 252 >5KKR-C nrPDB Length = 395 Score = 235 bits (599), Expect = 5e-62, Method: Composition-based stats. Identities = 73/351 (20%), Positives = 131/351 (37%), Gaps = 60/351 (17%) Query: 156 EPFHEYLDSMFFDRFLQWKWLER--------QPVTKNTFRQYRVLGKGGFGEVCACQVRA 207 E + L+ + D Q K LE + + F + LG G G V + Sbjct: 33 EALQKKLEELELDE-QQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKP 91 Query: 208 TGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMN 267 +G + A K + + K + + E Q+L + NS ++V A+ + + + + M+ Sbjct: 92 SGLVMARKLIHLE--IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMD 149 Query: 268 GGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL-HRENTVYRDLKPENILLDDYGHIR 326 GG L + G E+ + ++ GL L + ++RD+KP NIL++ G I+ Sbjct: 150 GGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIK 207 Query: 327 ISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFR 386 + D G++ ++ + + VGT YM+PE L Y + D W +G + EM G+ P Sbjct: 208 LCDFGVSGQLID-SMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIP 266 Query: 387 GRKEKVK---------------------------------------REEVDRRVLETEEV 407 K E +D V E Sbjct: 267 PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPK 326 Query: 408 YSHK-FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLE 457 FS E + L K+ +R ++ H F + + + ++ Sbjct: 327 LPSAVFSLEFQDFVNKCLIKNPAER-----ADLKQLMVHAFIKRSDAEEVD 372 >3SXS-A nrPDB Length = 268 Score = 235 bits (599), Expect = 5e-62, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 108/264 (40%), Gaps = 16/264 (6%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI 237 + + + LG G FG V + + A K +++ + E E Q Sbjct: 2 HMELKREEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIKEGSMS----EDEFFQEAQT 56 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + K++ +V + + +V ++ G L ++ + G G E + L ++ Sbjct: 57 MMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGK-GLEPSQLLEMCYDVCE 115 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGYMAP 354 G+ L ++RDL N L+D +++SD G+ + + + VGT V + AP Sbjct: 116 GMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS-VGTKFPVKWSAP 174 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVY-SHKF 412 EV + +Y D W G L++E+ G+ P+ + EV +V + +Y H Sbjct: 175 EVFHYFKYSSKSDVWAFGILMWEVFSLGKMPY----DLYTNSEVVLKVSQGHRLYRPHLA 230 Query: 413 SEEAKSICKMLLTKDAKQRLGCQE 436 S+ I + ++R Q+ Sbjct: 231 SDTIYQIMYSCWHELPEKRPTFQQ 254 >5KMM-A nrPDB Length = 329 Score = 234 bits (598), Expect = 6e-62, Method: Composition-based stats. Identities = 52/282 (18%), Positives = 101/282 (35%), Gaps = 28/282 (9%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVR-----ATGKMYACKRLEKKRIKKRKGESMALNE 234 + + LG+G FG+V + + A K L++ E Sbjct: 31 HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA---SESARQDFQRE 87 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP------------- 281 ++L + Q +V L +V M GDL + + G Sbjct: 88 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 147 Query: 282 GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL 341 + L A+++ G+ L + V+RDL N L+ ++I D G++ I D Sbjct: 148 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY 207 Query: 342 IRGRVGT---VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEV 397 R T + +M PE + +++ D W G +++E+ G+ P+ + + Sbjct: 208 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI 267 Query: 398 DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGA 439 + E E +I + ++ +QR ++ A Sbjct: 268 TQG---RELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA 306 >6FEX-A nrPDB Length = 321 Score = 234 bits (598), Expect = 6e-62, Method: Composition-based stats. Identities = 63/306 (20%), Positives = 114/306 (37%), Gaps = 41/306 (13%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQV----------------RATGKMYACKRLEKKR 221 R ++ R LG+G FGEV C+V + + A K L Sbjct: 10 RVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA 69 Query: 222 IKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM--- 278 K + + L E +I+ ++ ++ L D LC++ M GDL + Sbjct: 70 TKNARND--FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE 127 Query: 279 --------GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDL 330 G+P L AA+I G+ L N V+RDL N L+ + I+I+D Sbjct: 128 DKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 187 Query: 331 GLAVKIPEGDLIRGR---VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYE--MIEGQSPF 385 G++ + GD R + V + +MA E + ++ + D W G ++E M+ PF Sbjct: 188 GMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 247 Query: 386 RGRKEKVKREE----VDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEE---G 438 ++ E + + + + +++++QR + Sbjct: 248 GQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL 307 Query: 439 AAEVKR 444 A + Sbjct: 308 AEDALN 313 >4XI2-A nrPDB Length = 446 Score = 234 bits (597), Expect = 8e-62, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 110/265 (41%), Gaps = 16/265 (6%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 + + LG G FG V + R A K + + + E + E Sbjct: 179 YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIREGSMS----EDEFIEEA 233 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 +++ ++ + +V L + + ++ M G L ++ M + F+ ++ L ++ Sbjct: 234 KVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDV 292 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGYM 352 +E L + ++RDL N L++D G +++SD GL+ + + D VG V + Sbjct: 293 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLD-DEYTSSVGSKFPVRWS 351 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVY-SH 410 PEVL ++ D W G L++E+ G+ P+ E+ E + + +Y H Sbjct: 352 PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPY----ERFTNSETAEHIAQGLRLYRPH 407 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQ 435 SE +I + A +R + Sbjct: 408 LASERVYTIMYSCWHEKADERPSFK 432 >1BYG-A nrPDB Length = 278 Score = 234 bits (597), Expect = 9e-62, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 105/282 (37%), Gaps = 20/282 (7%) Query: 168 DRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG 227 D F + W + + + +GKG FG+V R G A K + K Sbjct: 9 DEFYRSGW----ALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI-----KNDAT 57 Query: 228 ESMALNEKQILEKVNSQFVVNLAYAY-ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286 L E ++ ++ +V L E K L +V M G L ++ + G + Sbjct: 58 AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 117 Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV 346 L ++ ++ +E L N V+RDL N+L+ + ++SD GL + Sbjct: 118 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL- 176 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETE 405 V + APE L +++ D W G L++E+ G+ P+ ++ V R + Sbjct: 177 -PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP---RIPLKDVVPRVEKGYK 232 Query: 406 EVYSHKFSEEAKSICKMLLTKDAKQRLGCQE--EGAAEVKRH 445 + K DA R + E +K H Sbjct: 233 MDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTH 274 >3M42-A nrPDB Length = 299 Score = 234 bits (597), Expect = 9e-62, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 110/284 (38%), Gaps = 47/284 (16%) Query: 178 RQPVTKNTFRQY-RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 ++ + ++ +VLG G G+V + T + +A K L+ A E + Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVE 62 Query: 237 ILEKV-NSQFVVNLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 + + +V + YE + L +V+ ++GG+L I + G+ F E A Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDD---YGHIRISDLGLAVKIPEGDLIRGRVGT 348 I ++ LH N +RD+KPEN+L ++++D G A + Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT----------- 171 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV----LET 404 ++Y S D W LG ++Y ++ G PF + R+ E Sbjct: 172 ----------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 221 Query: 405 EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + SEE K + + LL + QR+ E HP+ Sbjct: 222 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI 260 >4UY9-A nrPDB Length = 323 Score = 234 bits (597), Expect = 9e-62, Method: Composition-based stats. Identities = 58/267 (21%), Positives = 95/267 (35%), Gaps = 20/267 (7%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK-RKGESMALNEKQIL 238 + ++G GGFG+V G A K + + E ++ Sbjct: 5 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLF 62 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + ++ L + LCLV+ GG L + + + +A +I G Sbjct: 63 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARG 119 Query: 299 LEDLHRENT---VYRDLKPENILLD--------DYGHIRISDLGLAVKIPEGDLIRGRVG 347 + LH E ++RDLK NIL+ ++I+D GLA + + G Sbjct: 120 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAG 178 Query: 348 TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 T +MAPEV+ + D W G L++E++ G+ PFRG V L Sbjct: 179 TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP-- 236 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGC 434 E + + D R Sbjct: 237 IPSTCPEPFAKLMEDCWNPDPHSRPSF 263 >1LUF-A nrPDB Length = 343 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 61/287 (21%), Positives = 106/287 (36%), Gaps = 42/287 (14%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKRLEKKRIKKRKGESMALNE 234 +N R +G+G FG V + A G M A K L+++ ++ E Sbjct: 45 PRNNIEYVRDIGEGAFGRVFQAR--APGLLPYEPFTMVAVKMLKEEA--SADMQADFQRE 100 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM---------------- 278 ++ + ++ +V L +CL+ M GDL + +M Sbjct: 101 AALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTR 160 Query: 279 ------GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGL 332 G P L A ++ G+ L V+RDL N L+ + ++I+D GL Sbjct: 161 ARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGL 220 Query: 333 AVKIPEGDLIR---GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGR 388 + I D + + +M PE + RY D W G +++E+ G P+ G Sbjct: 221 SRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGM 280 Query: 389 -KEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGC 434 E+V D +L E E ++ ++ +K R Sbjct: 281 AHEEVIYYVRDGNILACPENCP----LELYNLMRLCWSKLPADRPSF 323 >2PSQ-A nrPDB Length = 370 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 115/285 (40%), Gaps = 31/285 (10%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKRLEKKRIKKRKGESM 230 + ++ + LG+G FG+V + K A K L+ +K S Sbjct: 75 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK--DLSD 132 Query: 231 ALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF------ 283 ++E ++++ + + ++NL A L +++ + G+L+ ++ PG Sbjct: 133 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI 192 Query: 284 ---EEERALF-----YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 EE+ F ++ G+E L + ++RDL N+L+ + ++I+D GLA Sbjct: 193 NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARD 252 Query: 336 IPEGDLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEK 391 I D + V +MAPE L ++ Y D W G L++E+ G SP+ G + Sbjct: 253 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 312 Query: 392 VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + + + + E + + QR ++ Sbjct: 313 ELFKLLKEGHRMDK---PANCTNELYMMMRDCWHAVPSQRPTFKQ 354 >3EQC-A nrPDB Length = 360 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 66/319 (20%), Positives = 121/319 (37%), Gaps = 51/319 (15%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 + + F + LG G G V + +G + A K + + K + + E Q+L Sbjct: 29 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 86 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + NS ++V A+ + + + + M+GG L + G E+ + ++ GL Sbjct: 87 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGL 144 Query: 300 EDL-HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN 358 L + ++RD+KP NIL++ G I++ D G++ ++ + + VGT YM+PE L Sbjct: 145 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQ 203 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVK------------------------- 393 Y + D W +G + EM G+ P K Sbjct: 204 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 263 Query: 394 --------------REEVDRRVLETEEVYSHK-FSEEAKSICKMLLTKDAKQRLGCQEEG 438 E +D V E FS E + L K+ +R Sbjct: 264 LNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER-----AD 318 Query: 439 AAEVKRHPFFRNMNFKRLE 457 ++ H F + + + ++ Sbjct: 319 LKQLMVHAFIKRSDAEEVD 337 >3DKO-A nrPDB Length = 318 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 107/258 (41%), Gaps = 14/258 (5%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKM---YACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + RV+G G FGEVC+ +++ GK A K L+ +K++ + L E I+ + + Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRD--FLCEASIMGQFDH 103 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 VV+L + +V+ M G L + F + + I G+ L Sbjct: 104 PNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQ-FTVIQLVGMLRGIAAGMRYLA 162 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG-DLIRGRVG---TVGYMAPEVLNN 359 V+RDL NIL++ ++SD GL+ I + + + G V + APE + Sbjct: 163 DMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQY 222 Query: 360 QRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 +++ + D W G +++E++ G+ P+ + + ++ Sbjct: 223 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG---YRLPAPMDCPAGLHQ 279 Query: 419 ICKMLLTKDAKQRLGCQE 436 + K+ +R ++ Sbjct: 280 LMLDCWQKERAERPKFEQ 297 >5X5O-A nrPDB Length = 310 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 52/261 (19%), Positives = 102/261 (39%), Gaps = 17/261 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + + + + G G FG V + + K A K+L K E +IL Sbjct: 10 VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-----------IEKEAEIL 58 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 ++ + ++ +V + G L +I + + + + + +A ++ G Sbjct: 59 SVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 118 Query: 299 LEDLHRE---NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 + LH E ++RDLK N+++ G ++I D G A + VGT +MAPE Sbjct: 119 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPE 177 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 V+ + + D + G +++EM+ + PF+G + V + Sbjct: 178 VIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEK--NERLTIPSSCPRS 235 Query: 416 AKSICKMLLTKDAKQRLGCQE 436 + DAK+R ++ Sbjct: 236 FAELLHQCWEADAKKRPSFKQ 256 >3I81-A nrPDB Length = 315 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 124/306 (40%), Gaps = 27/306 (8%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-----MYACKRLEKKRIKKRKGESMA 231 + V + R LG+G FG V + K A K + + + + E Sbjct: 11 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE--F 68 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP--------GF 283 LNE ++++ N VV L +++ +M GDLK ++ ++ Sbjct: 69 LNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPP 128 Query: 284 EEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR 343 + + A EI G+ L+ V+RDL N ++ + ++I D G+ I E D R Sbjct: 129 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 188 Query: 344 -GRVG--TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRG-RKEKVKREEVD 398 G G V +M+PE L + + D W G +++E+ + P++G E+V R ++ Sbjct: 189 KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVME 248 Query: 399 RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE--EGAAEVKRHPFFRNMNFKRL 456 +L+ + E + +M + K R E E P FR ++F Sbjct: 249 GGLLDKPDNCPDMLFE----LMRMCWQYNPKMRPSFLEIISSIKEEME-PGFREVSFYYS 303 Query: 457 EAGMLD 462 E ++ Sbjct: 304 EENKME 309 >4XCU-A nrPDB Length = 300 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 53/276 (19%), Positives = 107/276 (38%), Gaps = 22/276 (7%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATG-------KMYACKRLEKKRIKKRKGESM 230 ++ + LG+G FG+V + A K L+ K + Sbjct: 11 LWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA--SDKDLAD 68 Query: 231 ALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEE---- 285 ++E ++++ + + ++NL + L +++ G+L+ + PG E Sbjct: 69 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLS 128 Query: 286 -ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR- 343 + A ++ G++ L ++RDL N+L+ + ++I+D GLA + D + Sbjct: 129 FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 188 Query: 344 --GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRR 400 V +MAPE L ++ Y D W G L++E+ G SP+ G + + R Sbjct: 189 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS-LLRE 247 Query: 401 VLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + E + + QR ++ Sbjct: 248 GHRMDR--PPHCPPELYGLMRECWHAAPSQRPTFKQ 281 >4UYA-A nrPDB Length = 340 Score = 233 bits (595), Expect = 2e-61, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 103/285 (36%), Gaps = 27/285 (9%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F V ++G GGFG+V + G+ A K + Sbjct: 12 ENLYFQG-------SPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPE 62 Query: 223 KKRKGE-SMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP 281 + E ++ + ++ L + LCLVL GG L + Sbjct: 63 QDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL---AGR 119 Query: 282 GFEEERALFYAAEILCGLEDLHREN---TVYRDLKPENILLDD--------YGHIRISDL 330 + +A +I G+ LH E ++RDLK NILL + ++I+D Sbjct: 120 RIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDF 179 Query: 331 GLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390 GLA + + G +MAPEV+ + + D W G L++E++ G+ P+RG Sbjct: 180 GLAREWHRTTKMAT-AGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG 238 Query: 391 KVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 V L E + K +D R Sbjct: 239 LAVAYGVAVNKLTLP--IPSTCPEPFAKLMKECWQQDPHIRPSFA 281 >4X7Q-B nrPDB Length = 312 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 117/298 (39%), Gaps = 36/298 (12%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN---EKQILEKV 241 +R +LGKGGFG V A A K + + R+ S ++ E +L KV Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 242 N----SQFVVNLAYAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 V+ L +ET++ LVL + DL +I G E + + +++ Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGP--LGEGPSRCFFGQVV 149 Query: 297 CGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 ++ H V+RD+K ENIL+D G ++ D G + + + GT Y PE Sbjct: 150 AAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVYSPPE 208 Query: 356 VLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE 414 ++ +Y L W LG L+Y+M+ G PF E D+ +LE E + S Sbjct: 209 WISRHQYHALPATVWSLGILLYDMVCGDIPF----------ERDQEILEAELHFPAHVSP 258 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAV 472 + ++ + L R E+ P+ + D P P Sbjct: 259 DCCALIRRCLAPKPSSR-----PSLEEILLDPWMQTP--------AEDVPLNPSKGGP 303 >4O2Z-A nrPDB Length = 377 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 120/319 (37%), Gaps = 49/319 (15%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + ++LG G +G C+C TG+ + K+ + + + L E ++ + + Sbjct: 46 KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKC-RDVFRDVEDGKRVLREIDMMRFFHHE 104 Query: 245 FVVN-------LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 ++N L Y + + + +V +M D+ ++ EE ++ +IL Sbjct: 105 NLLNVVNILPPLKREYHSFEDVYVVTPLM---DVDMNVVLRSRQVLEESHMQYFVYQILR 161 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEV 356 GL+ LH N +RDLKP N++ + ++I D GL+ + + V T Y PE+ Sbjct: 162 GLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPEL 221 Query: 357 LN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE---------- 405 L N Y + D W +GC+ EM + F GR + + + + + Sbjct: 222 LLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREAL 281 Query: 406 ----------EVYSHKFS-----EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 E + T D +R AA++ HP+ + Sbjct: 282 EKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKR-----PTAADMLAHPYLAH 336 Query: 451 MNFKRLEAGMLDPPFVPDP 469 + D P P P Sbjct: 337 L------HDEEDEPTCPCP 349 >4EQM-A nrPDB Length = 294 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 109/265 (41%), Gaps = 5/265 (1%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + ++ LG GG V + A K + +K + E + Sbjct: 8 IINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQ 67 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 ++ Q +V++ E D LV+ + G L +I + G + A+ + +IL G++ Sbjct: 68 LSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGP--LSVDTAINFTNQILDGIK 125 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR--VGTVGYMAPEVLN 358 H V+RD+KP+NIL+D ++I D G+A + E L + +GTV Y +PE Sbjct: 126 HAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAK 185 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE-KVKREEVDRRVLETEEVYSHKFSEEAK 417 + D + +G ++YEM+ G+ PF G + + + V + Sbjct: 186 GEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSLS 245 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEV 442 ++ KD R +E ++ Sbjct: 246 NVILRATEKDKANRYKTIQEMKDDL 270 >3VN9-A nrPDB Length = 340 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 122/277 (44%), Gaps = 17/277 (6%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 V + LG+G +G V + +G++ A KR+ + + ++ + + ++ + Sbjct: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMR 105 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM--GNPGFEEERALFYAAEILC 297 V+ F V A + + + + +M+ L + E+ A I+ Sbjct: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 Query: 298 GLEDLHRE-NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 LE LH + + ++RD+KP N+L++ G +++ D G++ + + G YMAPE Sbjct: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 Query: 357 L----NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET-EEVYSHK 411 + N + Y + D W LG + E+ + P+ +++ + V E ++ + K Sbjct: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQVVEEPSPQLPADK 282 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 FS E L K++K+R E+ +HPFF Sbjct: 283 FSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 >3FME-A nrPDB Length = 290 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 61/279 (21%), Positives = 123/279 (44%), Gaps = 19/279 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 V + LG+G +G V + +G++ A KR+ + + ++ + + ++ + Sbjct: 2 MEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISM 60 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM--GNPGFEEERALFYAAEIL 296 V+ F V A + + + + +M+ L + E+ A I+ Sbjct: 61 RTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIV 119 Query: 297 CGLEDLHRE-NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 LE LH + + ++RD+KP N+L++ G +++ D G++ + + G YMAPE Sbjct: 120 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPE 179 Query: 356 VL----NNQRYGLSPDYWGLGCLIYEMIEGQSPF--RGRKEKVKREEVDRRVLETEEVYS 409 + N + Y + D W LG + E+ + P+ G + ++ V+ + ++ + Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP---SPQLPA 236 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 KFS E L K++K+R E+ +HPFF Sbjct: 237 DKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 270 >3CJF-A nrPDB Length = 309 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 123/312 (39%), Gaps = 41/312 (13%) Query: 157 PFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCAC----QVR-ATGKM 211 P E+ + + +D + ++ + LG+G FG+V + AT + Sbjct: 7 PLDEHCERLPYDA-------SKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRT 59 Query: 212 YACKRLEKKRIKKRKGESMALNEKQILEKVNSQ-FVVNLAYAYETKD-ALCLVLTIMNGG 269 A K L++ ++E +IL + VVNL A L +++ G Sbjct: 60 VAVKMLKEGATHSE--HRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFG 117 Query: 270 DLKFHIYNMGNPG----------FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL 319 +L ++ + N E + Y+ ++ G+E L ++RDL NILL Sbjct: 118 NLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILL 177 Query: 320 DDYGHIRISDLGLAVKIPEGDLIRGRVG----TVGYMAPEVLNNQRYGLSPDYWGLGCLI 375 + ++I D GLA I + D R G + +MAPE + ++ Y + D W G L+ Sbjct: 178 SEKNVVKICDFGLARDIYK-DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLL 236 Query: 376 YEMIE-GQSPFRGRKEKVKREEVDRRVLETEE-VYSHKFSEEAKSICKMLLTKDAKQRLG 433 +E+ G SP+ G K EE RR+ E + E + QR Sbjct: 237 WEIFSLGASPYPGVKID---EEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR-- 291 Query: 434 CQEEGAAEVKRH 445 +E+ H Sbjct: 292 ---PTFSELVEH 300 >5AMN-A nrPDB Length = 299 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 112/293 (38%), Gaps = 28/293 (9%) Query: 157 PFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQV-----RATGKM 211 P +D+ +W++ + + LG+G FG+V RA Sbjct: 2 PLSLSVDAFKILEDPKWEF------PRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT 55 Query: 212 YACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDL 271 A K L++ + L+E +L++VN V+ L A L L++ G L Sbjct: 56 VAVKMLKENASPSELRD--LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL 113 Query: 272 KFHIYNMGN--------PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG 323 + + + +A +I G++ L V+RDL NIL+ + Sbjct: 114 RGFLRESRKVGPGYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR 173 Query: 324 HIRISDLGLAVKIPEGDLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE 380 ++ISD GL+ + E D R V +MA E L + Y D W G L++E++ Sbjct: 174 KMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT 233 Query: 381 -GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRL 432 G +P+ G + + + E SEE + ++ +R Sbjct: 234 LGGNPYPGI-PPERLFNLLKTGHRMER--PDNCSEEMYRLMLQCWKQEPDKRP 283 >5MJB-A nrPDB Length = 305 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 50/268 (18%), Positives = 106/268 (39%), Gaps = 16/268 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGK---MYACKRLEKKRIKKRKGESMALNEK 235 + + + + V+G G FGEV +++ GK A K L+ +K++ + L+E Sbjct: 21 KEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRD--FLSEA 78 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 I+ + + + ++ L + ++ M L + F + + I Sbjct: 79 SIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQ-FTVIQLVGMLRGI 137 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---LIRGRVG---TV 349 G++ L N V+RDL NIL++ ++SD GL+ + + +G V Sbjct: 138 AAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPV 197 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVY 408 + APE + +++ + D W G +++E++ G+ P+ + +++ + Sbjct: 198 RWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ---DYRLPP 254 Query: 409 SHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + KD R E Sbjct: 255 PMDCPAALHQLMLDCWQKDRNSRPRFAE 282 >4P5Q-A nrPDB Length = 361 Score = 231 bits (590), Expect = 5e-61, Method: Composition-based stats. Identities = 51/260 (19%), Positives = 102/260 (39%), Gaps = 14/260 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKM---YACKRLEKKRIKKRKGESMALNEKQILEKV 241 +V+G G FGEVC+ +++ K A K L+ +K++ + L E I+ + Sbjct: 34 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRD--FLGEASIMGQF 91 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + ++ L + +V M G L + F + + I G++ Sbjct: 92 DHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ-FTVIQLVGMLRGIASGMKY 150 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL--IRGRVG--TVGYMAPEVL 357 L V+RDL NIL++ ++SD GL+ + + R G + + +PE + Sbjct: 151 LSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAI 210 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 +++ + D W G +++E++ G+ P+ + + VD Sbjct: 211 AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPP---PMDCPAAL 267 Query: 417 KSICKMLLTKDAKQRLGCQE 436 + KD R ++ Sbjct: 268 YQLMLDCWQKDRNNRPKFEQ 287 >4Y93-A nrPDB Length = 446 Score = 231 bits (589), Expect = 6e-61, Method: Composition-based stats. Identities = 51/263 (19%), Positives = 106/263 (40%), Gaps = 12/263 (4%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 + + LG G FG V + R A K +++ + E + E Sbjct: 180 YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMS----EDEFIEEA 234 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 +++ ++ + +V L + + ++ M G L ++ M + F+ ++ L ++ Sbjct: 235 KVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDV 293 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMA 353 +E L + ++RDL N L++D G +++SD G+ + + + G V + + Sbjct: 294 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWAS 353 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 PEVL ++ D W G L++E+ G+ P+ E + + H Sbjct: 354 PEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQG---LRLPRPHLA 410 Query: 413 SEEAKSICKMLLTKDAKQRLGCQ 435 SE +I + A +R + Sbjct: 411 SERVYAIMYSCWHEKADERPTFK 433 >2R2P-A nrPDB Length = 295 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 55/278 (19%), Positives = 111/278 (39%), Gaps = 16/278 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM---YACKRLEKKRIKKRKGESMALNEK 235 + + + RV+G G FGEVC+ +++ GK A K L+ +K++ + L E Sbjct: 17 KEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRD--FLGEA 74 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 I+ + + +++L + +V M G L + F + + I Sbjct: 75 SIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQ-FTVIQLVGMLRGI 133 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL--IRGRVG--TVGY 351 G++ L V+RDL NIL++ ++SD GL+ + + R G + + Sbjct: 134 SAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW 193 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 APE + +++ + D W G +++E++ G+ P+ + + V+ Sbjct: 194 TAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEG---YRLPSPM 250 Query: 411 KFSEEAKSICKMLLTKDAKQRLGCQE--EGAAEVKRHP 446 + K+ R E ++ R+P Sbjct: 251 DCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNP 288 >4K33-A nrPDB Length = 325 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 114/285 (40%), Gaps = 31/285 (10%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKRLEKKRIKKRKGESM 230 + +++ + LG+G FG+V + K A K L+ K S Sbjct: 30 KWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDK--DLSD 87 Query: 231 ALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF------ 283 ++E ++++ + + ++NL A L +++ G+L+ + PG Sbjct: 88 LVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT 147 Query: 284 ---EEERALF-----YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 EE+ F A ++ G+E L + ++RDL N+L+ + ++I+D GLA Sbjct: 148 SKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD 207 Query: 336 IPEGDLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEK 391 + D + V +MAPE L ++ Y D W G L++E+ G SP+ G + Sbjct: 208 VHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE 267 Query: 392 VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + + + + + I + QR ++ Sbjct: 268 ELFKLLKEGHRMDK---PANCTHDLYMIMRECWHAAPSQRPTFKQ 309 >6BSD-A nrPDB Length = 876 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 62/312 (19%), Positives = 112/312 (35%), Gaps = 47/312 (15%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQV----------------RATGKMYACKRLEKKR 221 R ++ R LG+G FGEV C+V + + A K L Sbjct: 565 RVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA 624 Query: 222 IKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG-- 279 K + + L E +I+ ++ ++ L D LC++ M GDL + Sbjct: 625 TKNARND--FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE 682 Query: 280 ---------------NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH 324 P L AA+I G+ L N V+RDL N L+ + Sbjct: 683 DKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 742 Query: 325 IRISDLGLAVKIPEGDLIRGR---VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYE--MI 379 I+I+D G++ + GD R + V + +MA E + ++ + D W G ++E M+ Sbjct: 743 IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLML 802 Query: 380 EGQSPFRGRKEKVKREE----VDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 PF ++ E + + + + +++++QR Sbjct: 803 CRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFS 862 Query: 436 EE---GAAEVKR 444 + A + Sbjct: 863 QLHRFLAEDALN 874 >3DTC-A nrPDB Length = 271 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 94/267 (35%), Gaps = 20/267 (7%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK-RKGESMALNEKQIL 238 + ++G GGFG+V G A K + + E ++ Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLF 60 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + ++ L + LCLV+ GG L + + + +A +I G Sbjct: 61 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARG 117 Query: 299 LEDLHRENT---VYRDLKPENILLD--------DYGHIRISDLGLAVKIPEGDLIRGRVG 347 + LH E ++RDLK NIL+ ++I+D GLA + + G Sbjct: 118 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAG 176 Query: 348 TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 +MAPEV+ + D W G L++E++ G+ PFRG V L Sbjct: 177 AYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP-- 234 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGC 434 E + + D R Sbjct: 235 IPSTCPEPFAKLMEDCWNPDPHSRPSF 261 >2Y6O-A nrPDB Length = 291 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 51/278 (18%), Positives = 114/278 (41%), Gaps = 16/278 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM---YACKRLEKKRIKKRKGESMALNEK 235 + + + + +V+G G FGEVC+ +++ GK A K L+ K++ + L+E Sbjct: 9 KEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRD--FLSEA 66 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 I+ + + +++L + ++ M G L + + F + + I Sbjct: 67 SIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKN-DGRFTVIQLVGMLRGI 125 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL--IRGRVG--TVGY 351 G++ L + V+RDL NIL++ ++SD G++ + + R G + + Sbjct: 126 GSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRW 185 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 APE + +++ + D W G +++E++ G+ P+ + + ++ Sbjct: 186 TAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPP---PM 242 Query: 411 KFSEEAKSICKMLLTKDAKQR--LGCQEEGAAEVKRHP 446 + K+ R G ++ R+P Sbjct: 243 DCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNP 280 >1FVR-A nrPDB Length = 327 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 57/273 (20%), Positives = 115/273 (42%), Gaps = 27/273 (9%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMY--ACKRLEKKRIKKRKGESMALNEKQILEKV 241 N + V+G+G FG+V +++ G A KR+ K + E ++L K+ Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRM--KEYASKDDHRDFAGELEVLCKL 82 Query: 242 -NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--------------NPGFEEE 286 + ++NL A E + L L + G+L + + Sbjct: 83 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV 346 + L +AA++ G++ L ++ ++RDL NIL+ + +I+D GL+ + ++ + Sbjct: 143 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR--GQEVYVKKTM 200 Query: 347 G--TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLE 403 G V +MA E LN Y + D W G L++E++ G +P+ G E++ + Sbjct: 201 GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRL 260 Query: 404 TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + + +E + + + +R + Sbjct: 261 EKPLNCD---DEVYDLMRQCWREKPYERPSFAQ 290 >3QGY-A nrPDB Length = 286 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 95/252 (37%), Gaps = 14/252 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + +G G FG V K A K +++ + E + E +++ K++ Sbjct: 28 ELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMS----EDDFIEEAEVMMKLSHP 82 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 +V L + +CLV M G L ++ F E L ++ G+ L Sbjct: 83 KLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ-RGLFAAETLLGMCLDVCEGMAYLEE 141 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT---VGYMAPEVLNNQR 361 ++RDL N L+ + I++SD G+ + + D GT V + +PEV + R Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLD-DQYTSSTGTKFPVKWASPEVFSFSR 200 Query: 362 YGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Y D W G L++E+ G+ P+ R E++ S I Sbjct: 201 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTG---FRLYKPRLASTHVYQIM 257 Query: 421 KMLLTKDAKQRL 432 + + R Sbjct: 258 NHCWKERPEDRP 269 >6DBM-A nrPDB Length = 318 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 110/277 (39%), Gaps = 31/277 (11%) Query: 183 KNTFRQYRVLGKGGFGEV----CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 K ++ R LG+G FG+V TG+M A K L+ + S E IL Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADA--GPQHRSGWKQEIDIL 87 Query: 239 EKVNSQFVVNLAYAYETKD--ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 + + ++ E +L LV+ + G L+ ++ + L +A +I Sbjct: 88 RTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQIC 144 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV----GTVGYM 352 G+ LH ++ ++RDL N+LLD+ ++I D GLA +PEG V + Sbjct: 145 EGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 204 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIEGQ-----SP--F-------RGRKEKVKREEVD 398 APE L ++ + D W G +YE++ P F +G+ ++ E+ Sbjct: 205 APECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELL 264 Query: 399 RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 R K E + K +A R + Sbjct: 265 ERGERLPR--PDKCPAEVYHLMKNCWETEASFRPTFE 299 >1AD5-A nrPDB Length = 438 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 53/264 (20%), Positives = 104/264 (39%), Gaps = 19/264 (7%) Query: 173 WKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMAL 232 W+ + + + + + + LG G FGEV A K ++ + L Sbjct: 172 WE-KDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS----VEAFL 225 Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 E +++ + +V L A TK+ + ++ M G L + + + + ++ Sbjct: 226 AEANVMKTLQHDKLVKLH-AVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFS 284 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYM 352 A+I G+ + + N ++RDL+ NIL+ +I+D GLA G + + Sbjct: 285 AQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR--------VGAKFPIKWT 336 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 APE +N + + D W G L+ E++ G+ P+ G ++R Sbjct: 337 APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERG-YRMPR--PEN 393 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQ 435 EE +I ++R + Sbjct: 394 CPEELYNIMMRCWKNRPEERPTFE 417 >5Y86-A nrPDB Length = 588 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 69/338 (20%), Positives = 120/338 (35%), Gaps = 79/338 (23%) Query: 180 PVTKN----TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 V ++ + +++GKG FG+V + A K + ++ + A E Sbjct: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK----RFHRQAAEEI 254 Query: 236 QILEKVN------SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERAL 289 +ILE + S V+++ ++ ++ +C+ +++ DL I GF + Sbjct: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVR 313 Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH--IRISDLGLAVKIPEGDLIRGRVG 347 +A IL L+ LH+ ++ DLKPENILL +G ++ D G + E + + Sbjct: 314 KFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQ 371 Query: 348 TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFR---------------GRKEKV 392 + Y APE++ RY D W GC++ E++ GQ F G Sbjct: 372 SRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPK 431 Query: 393 KREEVDR-RVLETEEVYSHKFS------------------------EEAKS--------- 418 E+ R + + S +K Sbjct: 432 LLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCD 491 Query: 419 ------ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 K L D RL A+ RHP+ Sbjct: 492 DYLFIEFLKRCLHWDPSARLTP-----AQALRHPWISK 524 >3DLS-A nrPDB Length = 335 Score = 229 bits (583), Expect = 4e-60, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 122/303 (40%), Gaps = 27/303 (8%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKR------IKKRKGESMALNEKQIL 238 + LG G FG V + K K ++K++ I+ K + L E IL Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTL-EIAIL 83 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 +V ++ + +E + LV+ +G DL I +P +E A + +++ Sbjct: 84 SRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFI--DRHPRLDEPLASYIFRQLVS 141 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL 357 + L ++ ++RD+K ENI++ + I++ D G A + G L GT+ Y APEVL Sbjct: 142 AVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVL 201 Query: 358 NNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 Y G + W LG +Y ++ ++PF +E V E + S+E Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETV----------EAAIHPPYLVSKEL 251 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN-MNFKRLEAGMLDPPFVPDPRAVYCK 475 S+ LL ++R ++ P+ +N + P+ + Sbjct: 252 MSLVSGLLQPVPERRTTLEKLVTD-----PWVTQPVNLADYTWEEVFRVNKPESGVLSAA 306 Query: 476 DVL 478 + Sbjct: 307 SLE 309 >5L6P-A nrPDB Length = 298 Score = 229 bits (583), Expect = 4e-60, Method: Composition-based stats. Identities = 50/272 (18%), Positives = 110/272 (40%), Gaps = 18/272 (6%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKM---YACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + V+G G FGEVC +++ G+ A K L+ ++++ + L+E I+ + + Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRD--FLSEASIMGQFDH 79 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 ++ L + ++ M L + + + F + + I G++ L Sbjct: 80 PNIIRLEGVVTKSRPVMILTEFMENCALDSFLR-LNDGQFTVIQLVGMLRGIAAGMKYLS 138 Query: 304 RENTVYRDLKPENILLDDYGHIRISDLGLAVKI---PEGDLIRGRVG---TVGYMAPEVL 357 N V+RDL NIL++ ++SD GL+ + P +G + + APE + Sbjct: 139 EMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAI 198 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 +++ + D W G +++E++ G+ P+ + V++ + Sbjct: 199 AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQ---DYRLPPPMDCPTAL 255 Query: 417 KSICKMLLTKDAKQRLGCQE--EGAAEVKRHP 446 + +D R + ++ R+P Sbjct: 256 HQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNP 287 >5EG3-A nrPDB Length = 334 Score = 228 bits (582), Expect = 5e-60, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 115/285 (40%), Gaps = 31/285 (10%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKRLEKKRIKKRKGESM 230 + ++ + LG+G FG+V + K A K L+ +K S Sbjct: 29 KWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK--DLSD 86 Query: 231 ALNEKQILEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF------ 283 ++E ++++ + + ++NL A L +++ + G+L+ ++ PG Sbjct: 87 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDI 146 Query: 284 ---EEERALF-----YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 EE+ F ++ G+E L + ++RDL N+L+ + ++I+D GLA Sbjct: 147 NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARD 206 Query: 336 IPEGDLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEK 391 I D + V +MAPE L ++ Y D W G L++E+ G SP+ G + Sbjct: 207 INNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 266 Query: 392 VKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 + + + + E + + QR ++ Sbjct: 267 ELFKLLKEGHRMDK---PANCTNELYMMMRDCWHAVPSQRPTFKQ 308 >2WTK-C nrPDB Length = 305 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 125/295 (42%), Gaps = 22/295 (7%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK-RKGESMALNEKQILEKVNS 243 + +LG+G +G+V T A K L+KK++++ GE+ E Q+L ++ Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 244 QFVVNLAYAY--ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 + V+ L E K + +V+ G ++ + ++ F +A Y +++ GLE Sbjct: 66 KNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLIDGLEY 124 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE---GDLIRGRVGTVGYMAPEVLN 358 LH + V++D+KP N+LL G ++IS LG+A + D R G+ + PE+ N Sbjct: 125 LHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIAN 184 Query: 359 N--QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 G D W G +Y + G PF G E + + S Sbjct: 185 GLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLS--- 241 Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRA 471 + K +L + +R + ++++H +FR K+ P P P Sbjct: 242 -DLLKGMLEYEPAKRFSIR-----QIRQHSWFR----KKHPPAEAPVPIPPSPDT 286 >4OLI-A nrPDB Length = 645 Score = 227 bits (580), Expect = 8e-60, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 110/277 (39%), Gaps = 31/277 (11%) Query: 183 KNTFRQYRVLGKGGFGEV----CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 K ++ R LG+G FG+V TG+M A K L+ + S E IL Sbjct: 352 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD--CGPQHRSGWKQEIDIL 409 Query: 239 EKVNSQFVVNLAYAYETKDA--LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 + + ++ E + L LV+ + G L+ ++ + L +A +I Sbjct: 410 RTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQIC 466 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV----GTVGYM 352 G+ LH ++ ++R+L N+LLD+ ++I D GLA +PEG V + Sbjct: 467 EGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 526 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIEGQ-----SP--F-------RGRKEKVKREEVD 398 APE L ++ + D W G +YE++ P F +G+ ++ E+ Sbjct: 527 APECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELL 586 Query: 399 RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 R K E + K +A R + Sbjct: 587 ERGERLPR--PDKCPCEVYHLMKNCWETEASFRPTFE 621 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 78/243 (32%), Gaps = 22/243 (9%) Query: 203 CQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLV 262 + R K L+ ++ +V+ + + +V Sbjct: 88 GRDRGQELRVVLKVLDPSH---HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 144 Query: 263 LTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDY 322 + G L + + A ++ L L +N V+ ++ NILL Sbjct: 145 TEYVEHGPLDVWLR-RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 203 Query: 323 GH-------IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ--RYGLSPDYWGLGC 373 G I++SD G+ + + R + ++APE L + D WG G Sbjct: 204 GLAEGTSPFIKLSDPGVGLGALSREERVER---IPWLAPECLPGGANSLSTAMDKWGFGA 260 Query: 374 LIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRL 432 + E+ G++P + R K R + + ++ LT + QR Sbjct: 261 TLLEICFDGEAPLQSRSPSEKEHFYQR-----QHRLPEPSCPQLATLTSQCLTYEPTQRP 315 Query: 433 GCQ 435 + Sbjct: 316 SFR 318 >4HZS-A nrPDB Length = 341 Score = 227 bits (580), Expect = 9e-60, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 96/262 (36%), Gaps = 12/262 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVR-ATGKMY--ACKRLEKKRIKKRKGESMALNEKQI 237 + + R LG G FG V + +GK A K L+ + + + + E Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 68 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + ++ + ++ L T + +V + G L + F YA ++ Sbjct: 69 MHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKH-QGHFLLGTLSRYAVQVAE 126 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GRVGTVGYMA 353 G+ L + ++RDL N+LL ++I D GL +P+ D R + A Sbjct: 127 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 186 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 PE L + + + D W G ++EM GQ P+ G ++D+ Sbjct: 187 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPR--PEDC 244 Query: 413 SEEAKSICKMLLTKDAKQRLGC 434 ++ ++ + R Sbjct: 245 PQDIYNVMVQCWAHKPEDRPTF 266 >1U54-B nrPDB Length = 291 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 96/262 (36%), Gaps = 12/262 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVR-ATGKMY--ACKRLEKKRIKKRKGESMALNEKQI 237 + + R LG G FG V + +GK A K L+ + + + + E Sbjct: 15 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 74 Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + ++ + ++ L T + +V + G L + F YA ++ Sbjct: 75 MHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKH-QGHFLLGTLSRYAVQVAE 132 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GRVGTVGYMA 353 G+ L + ++RDL N+LL ++I D GL +P+ D R + A Sbjct: 133 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 192 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 PE L + + + D W G ++EM GQ P+ G ++D+ Sbjct: 193 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPR--PEDC 250 Query: 413 SEEAKSICKMLLTKDAKQRLGC 434 ++ ++ + R Sbjct: 251 PQDIYNVMVQCWAHKPEDRPTF 272 >2VWV-A nrPDB Length = 302 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 105/264 (39%), Gaps = 16/264 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM---YACKRLEKKRIKKRKGESMALNEK 235 + + + + V+G G FGEVC +++A GK A K L+ ++++ E L+E Sbjct: 11 KEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRRE--FLSEA 68 Query: 236 QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 I+ + ++ L + ++ M G L + + + F + + I Sbjct: 69 SIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLR-LNDGQFTVIQLVGMLRGI 127 Query: 296 LCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG------TV 349 G+ L + V+RDL NIL++ ++SD GL+ + E + Sbjct: 128 ASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPI 187 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVY 408 + APE + +++ + D W G +++E++ G+ P+ + +++ + Sbjct: 188 RWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ---DYRLPP 244 Query: 409 SHKFSEEAKSICKMLLTKDAKQRL 432 + KD R Sbjct: 245 PPDCPTSLHQLMLDCWQKDRNARP 268 >4E20-A nrPDB Length = 290 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 27/275 (9%) Query: 183 KNTFRQYRVLGKGGFGEV----CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 K ++ R LG+G FG+V TG+M A K L++ + S E +IL Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEG--CGPQLRSGWQREIEIL 64 Query: 239 EKVNSQFVVNLAYAYETKDA--LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 + + +V E + + LV+ + G L+ ++ + L +A +I Sbjct: 65 RTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC---VGLAQLLLFAQQIC 121 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV----GTVGYM 352 G+ LH ++ ++R L N+LLD+ ++I D GLA +PEG V + Sbjct: 122 EGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 181 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIE----GQSPFRGRKEKVKREEVDRRVLETEEVY 408 APE L ++ + D W G +YE++ QSP E + + VL E+ Sbjct: 182 APECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELL 241 Query: 409 --------SHKFSEEAKSICKMLLTKDAKQRLGCQ 435 + E + K +A R Q Sbjct: 242 ERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQ 276 >5B2L-A nrPDB Length = 324 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 66/282 (23%), Positives = 119/282 (42%), Gaps = 20/282 (7%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 +R N +G G G+V + R TG + A K++ + K + + + ++ Sbjct: 10 QRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSG-NKEENKRILMDLDV 68 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +L+ + ++V + T + + + +M G + E I+ Sbjct: 69 VLKSHDCPYIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIV 126 Query: 297 CGLEDL-HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 L L + ++RD+KP NILLD+ G I++ D G++ ++ + G YMAPE Sbjct: 127 KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPE 186 Query: 356 VLN-----NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 ++ Y + D W LG + E+ GQ P++ K EV +VL+ E Sbjct: 187 RIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDF---EVLTKVLQEEPPLLP 243 Query: 411 ---KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 FS + +S K LTKD ++R ++ H F + Sbjct: 244 GHMGFSGDFQSFVKDCLTKDHRKR-----PKYNKLLEHSFIK 280 >1ZXE-A nrPDB Length = 303 Score = 226 bits (576), Expect = 3e-59, Method: Composition-based stats. Identities = 68/281 (24%), Positives = 117/281 (41%), Gaps = 38/281 (13%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F + VLG+G FG+V + + YA K++ + S L+E +L +N Q Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHT----EEKLSTILSEVMLLASLNHQ 62 Query: 245 FVVNLAYAYETKDA-------------LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 +VV A+ + L + + L I++ N + + Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHS-ENLNQQRDEYWRL 121 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-------------- 337 +IL L +H + ++R+LKP NI +D+ +++I D GLA + Sbjct: 122 FRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLP 181 Query: 338 -EGDLIRGRVGTVGYMAPEVLNNQ-RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE 395 D + +GT Y+A EVL+ Y D + LG + +EMI PF E+V Sbjct: 182 GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNIL 238 Query: 396 EVDRRV-LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 + R V +E + + K I ++L+ D +R G + Sbjct: 239 KKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGAR 279 >5U6C-A nrPDB Length = 315 Score = 225 bits (575), Expect = 3e-59, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 116/290 (40%), Gaps = 23/290 (7%) Query: 163 DSMFFD--RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVR---ATGKMYACKRL 217 ++++F LQ K LE + +N ++LG+G FG V ++ T A K + Sbjct: 14 ENLYFQGSEELQNK-LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTM 72 Query: 218 EKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETK-----DALCLVLTIMNGGDLK 272 + +R+ E L+E ++ + V+ L ++L M GDL Sbjct: 73 KLDNSSQREIEE-FLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 131 Query: 273 FHIY----NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRIS 328 ++ G + L + +I G+E L N ++RDL N +L D + ++ Sbjct: 132 TYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVA 191 Query: 329 DLGLAVKIPEGDLIR-GRVG--TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSP 384 D GL+ KI GD R GR+ V ++A E L ++ Y D W G ++E+ G +P Sbjct: 192 DFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTP 251 Query: 385 FRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGC 434 + G + E D + +E I D R Sbjct: 252 YPGVQN---HEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTF 298 >5FM2-A nrPDB Length = 355 Score = 225 bits (574), Expect = 4e-59, Method: Composition-based stats. Identities = 64/324 (19%), Positives = 111/324 (34%), Gaps = 49/324 (15%) Query: 140 ELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGE 199 S+ + + F D + + + LG+G FG+ Sbjct: 33 GARRPSLDSMENQVSVDAFKILED-------------PKWEFPRKNLVLGKTLGEGEFGK 79 Query: 200 VCACQV-----RATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYE 254 V RA A K L++ + L+E +L++VN V+ L A Sbjct: 80 VVKATAFHLKGRAGYTTVAVKMLKENASPSELRD--LLSEFNVLKQVNHPHVIKLYGACS 137 Query: 255 TKDALCLVLTIMNGGDLKFHIYNMGN----------------------PGFEEERALFYA 292 L L++ G L+ + + +A Sbjct: 138 QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFA 197 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TV 349 +I G++ L V+RDL NIL+ + ++ISD GL+ + E D R V Sbjct: 198 WQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV 257 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVY 408 +MA E L + Y D W G L++E++ G +P+ G + + + E Sbjct: 258 KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMER-- 314 Query: 409 SHKFSEEAKSICKMLLTKDAKQRL 432 SEE + ++ +R Sbjct: 315 PDNCSEEMYRLMLQCWKQEPDKRP 338 >3BBT-B nrPDB Length = 328 Score = 225 bits (573), Expect = 5e-59, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 105/264 (39%), Gaps = 15/264 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEK 240 ++ +VLG G FG V G+ A K L + K E ++E I+ Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE--FMDEALIMAS 73 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 ++ +V L + + LV +M G L +++ + + L + +I G+ Sbjct: 74 MDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKD-NIGSQLLLNWCVQIAKGMM 131 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGYMAPEVL 357 L V+RDL N+L+ H++I+D GLA + + G + +MA E + Sbjct: 132 YLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECI 191 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 + +++ D W G I+E++ G P+ G + + +++ + + Sbjct: 192 HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKG---ERLPQPPICTIDV 248 Query: 417 KSICKMLLTKDAKQRLGCQEEGAA 440 + DA R +E A Sbjct: 249 YMVMVKCWMIDADSRPKFKELAAE 272 >3ZBF-A nrPDB Length = 322 Score = 225 bits (573), Expect = 6e-59, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 108/295 (36%), Gaps = 31/295 (10%) Query: 163 DSMFFDRFLQWKWLERQP-VTKNTFRQYRVLGKGGFGEVCACQVR-----ATGKM-YACK 215 ++++F +E P + +LG G FGEV +G++ A K Sbjct: 16 ENLYFQ-----GSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK 70 Query: 216 RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275 L+K + K E L E ++ K N ++ + ++L +M GGDL ++ Sbjct: 71 TLKKGSTDQEKIE--FLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYL 128 Query: 276 YNMGNPGF-----EEERALFYAAEILCGLEDLHRENTVYRDLKPENILL-----DDYGHI 325 F + +I G L R + ++RDL N L+ + Sbjct: 129 RKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIV 188 Query: 326 RISDLGLAVKIPEGDLIRGR---VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-G 381 +I D GLA I + D R R + V +MAPE L + + D W G LI+E++ G Sbjct: 189 KIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLG 248 Query: 382 QSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 P+ V ++ ++ ++ QR Sbjct: 249 HQPYPAHSNLDVLNYVQTG---GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHR 300 >4M7I-A nrPDB Length = 299 Score = 224 bits (571), Expect = 8e-59, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 119/295 (40%), Gaps = 38/295 (12%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F + LG+GGFG V + + YA KR+ + + E + L K+ Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN--RELAREKVMREVKALAKLEHP 63 Query: 245 FVVNLAYAYETKD------------ALCLVLTIMNGGDLKFHIYNMGNPGFEEERA-LFY 291 +V A+ K+ L + + + +LK + E L Sbjct: 64 GIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHI 123 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL---------- 341 +I +E LH + ++RDLKP NI +++ D GL + + + Sbjct: 124 FLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 342 ---IRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVD 398 G+VGT YM+PE ++ Y D + LG +++E++ PF + E+V R D Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL---YPFSTQMERV-RTLTD 239 Query: 399 RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNF 453 R L+ +++ K+ E + +L+ +R A + + F +++F Sbjct: 240 VRNLKFPPLFTQKYPCEYVM-VQDMLSPSPMER-----PEAINIIENAVFEDLDF 288 >2I6L-A nrPDB Length = 320 Score = 224 bits (571), Expect = 9e-59, Method: Composition-based stats. Identities = 67/315 (21%), Positives = 121/315 (38%), Gaps = 58/315 (18%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + + LG GG G V + K A K++ + + AL E +I+ +++ Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALREIKIIRRLDHD 68 Query: 245 FVVNLA--------------YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF 290 +V + + +++ +V M DL + EE A Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVLEQ---GPLLEEHARL 124 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGR---- 345 + ++L GL+ +H N ++RDLKP N+ ++ + ++I D GLA + +G Sbjct: 125 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 184 Query: 346 VGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV--- 401 + T Y +P +L + Y + D W GC+ EM+ G++ F G E + + + + Sbjct: 185 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 244 Query: 402 ---------------LETEEVYSHK--------FSEEAKSICKMLLTKDAKQRLGCQEEG 438 + + HK S EA + +LT RL Sbjct: 245 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLT----- 299 Query: 439 AAEVKRHPFFRNMNF 453 A E HP+ +F Sbjct: 300 AEEALSHPYMSIYSF 314 >4PDO-A nrPDB Length = 299 Score = 224 bits (571), Expect = 9e-59, Method: Composition-based stats. Identities = 47/255 (18%), Positives = 103/255 (40%), Gaps = 15/255 (5%) Query: 187 RQYRVLGKGGFGEVCACQVR-ATGKM---YACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + +V+G G FGEV ++ ++GK A K L+ +K++ + L E I+ + + Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVD--FLGEAGIMGQFS 94 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 ++ L + ++ M G L + + F + + I G++ L Sbjct: 95 HHNIIRLEGVISKYKPMMIITEYMENGALDKFLRE-KDGEFSVLQLVGMLRGIAAGMKYL 153 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG--DLIRGRVG--TVGYMAPEVLN 358 N V+RDL NIL++ ++SD GL+ + + G + + APE ++ Sbjct: 154 ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAIS 213 Query: 359 NQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 +++ + D W G +++E++ G+ P+ + ++ Sbjct: 214 YRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDG---FRLPTPMDCPSAIY 270 Query: 418 SICKMLLTKDAKQRL 432 + ++ +R Sbjct: 271 QLMMQCWQQERARRP 285 >5HI2-A nrPDB Length = 283 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 109/272 (40%), Gaps = 19/272 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + + + +G G FG V + A K L ++++ NE Sbjct: 13 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQ------AFKNEVG 63 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +L K ++ L Y TK L +V G L H++ FE ++ + A + Sbjct: 64 VLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHASETK-FEMKKLIDIARQTA 121 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMA 353 G++ LH ++ ++RDLK NI L + ++I D GLA + G++ +MA Sbjct: 122 RGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMA 181 Query: 354 PEVLN---NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV--Y 408 PEV+ + Y D + G ++YE++ GQ P+ + + E+ R + ++ Sbjct: 182 PEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKV 241 Query: 409 SHKFSEEAKSICKMLLTKDAKQRLGCQEEGAA 440 + K + L K +R A Sbjct: 242 RSNCPKRMKRLMAECLKKKRDERPSFPRILAE 273 >6FER-A nrPDB Length = 309 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 61/291 (20%), Positives = 107/291 (36%), Gaps = 35/291 (12%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGK----------------MYACKRLEKKRI 222 + + LG+G FGEV C+V K + A K L Sbjct: 4 EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADAN 63 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG 282 K + + L E +I+ ++ +++L T D LC++ M GDL + P Sbjct: 64 KNARND--FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN 121 Query: 283 FEEERAL--------FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV 334 F A +I G++ L N V+RDL N L+ I+I+D G++ Sbjct: 122 SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSR 181 Query: 335 KIPEGDLIRGR---VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEG--QSPFRGRK 389 + GD R + V + +M+ E + ++ + D W G ++E + P+ Sbjct: 182 NLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLS 241 Query: 390 EKVKREEV----DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 ++ E + +T + + +D K R QE Sbjct: 242 DEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE 292 >5VD3-A nrPDB Length = 311 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 75/266 (28%), Positives = 112/266 (42%), Gaps = 12/266 (4%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV- 241 + +F++ LG G +GEV + + G++YA KR + K + L E EKV Sbjct: 56 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-SMSPFRGPKDRARKLAEVGSHEKVG 114 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 V L A+E L L + G L+ H G E + Y + L L Sbjct: 115 QHPCCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGA-SLPEAQVWGYLRDTLLALAH 172 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 LH + V+ D+KP NI L G ++ D GL V++ + G YMAPE+L Sbjct: 173 LHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS- 231 Query: 362 YGLSPDYWGLGCLIYEMIEG-QSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 YG + D + LG I E+ + P G + R+ ++ S E +S+ Sbjct: 232 YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYL------PPEFTAGLSSELRSVL 285 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHP 446 M+L D K R + A V R P Sbjct: 286 VMMLEPDPKLRATAEALLALPVLRQP 311 >5TQX-A nrPDB Length = 655 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 82/294 (27%), Positives = 128/294 (43%), Gaps = 36/294 (12%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 + LG GGFG VC Q R A K + K + +E QI++K+N Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNR--ERWCHEIQIMKKLNHAN 67 Query: 246 VVNLAYAYETKDALC-----LVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGL 299 VV E + L L + +GGDL+ + N G +E + L ++I G+ Sbjct: 68 VVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGI 127 Query: 300 EDLHRENTVYRDLKPENILLDD-YGHI--RISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 LH ++RDLKPENI+L D G I +I DLG A + +G+L VGT+ Y+APE+ Sbjct: 128 RYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPEL 187 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV----------LETEE 406 N+ Y + DYW G +++E I G PF + E ++ + E Sbjct: 188 FENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEV 247 Query: 407 VYSHKFSE--EAKSIC--------KMLLTKDAKQRLGCQEEGAAE-----VKRH 445 +S + S+ +++L D +QR G + + + H Sbjct: 248 RFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDH 301 >5UIU-A nrPDB Length = 323 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 123/315 (39%), Gaps = 39/315 (12%) Query: 163 DSMFFD-----------RFLQWKWLERQPVTKNTFRQ------YRVLGKGGFGEVCACQV 205 ++++F RF + + E + VT N F + +G+GGFG V V Sbjct: 10 ENLYFQGENKSLEVSDTRFHSFSFYELKNVT-NNFDERPISVGGNKMGEGGFGVVYKGYV 68 Query: 206 RATGKMYACKRLE-KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLT 264 T A K+L I + + E +++ K + +V L D LCLV Sbjct: 69 NNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYV 126 Query: 265 IMNGGDLKFHIYNM-GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG 323 M G L + + G P A G+ LH + ++RD+K NILLD+ Sbjct: 127 YMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAF 186 Query: 324 HIRISDLGLAV---KIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE 380 +ISD GLA K + + VGT YMAPE L + D + G ++ E+I Sbjct: 187 TAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-TPKSDIYSFGVVLLEIIT 245 Query: 381 GQSPFRGRKEKVKREEVDRRVLETEEVYSHKF----------SEEA-KSICKMLLTKDAK 429 G +E ++ + + E+ S EA S+ L + Sbjct: 246 GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKN 305 Query: 430 QRLGCQEEGAAEVKR 444 +R ++ ++ + Sbjct: 306 KRPDIKK--VQQLLQ 318 >4PWN-A nrPDB Length = 274 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 62/268 (23%), Positives = 113/268 (42%), Gaps = 21/268 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G+G F V T A L+ +++ K + + E ++L+ + +V Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQR-FKEEAEMLKGLQHPNIVRFYD 76 Query: 252 AYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE-- 305 ++E+ K + LV +M G LK ++ + + +IL GL+ LH Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKV--LRSWCRQILKGLQFLHTRTP 134 Query: 306 NTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 ++RDLK +NI + G ++I DLGLA + +GT +MAPE+ ++Y Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY-EEKYDE 193 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET--EEVYSHKFSEEAKSICKM 422 S D + G + EM + P+ E ++ RRV + E K I + Sbjct: 194 SVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEG 250 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + ++ +R ++ H FF+ Sbjct: 251 CIRQNKDERYSI-----KDLLNHAFFQE 273 >3KUL-B nrPDB Length = 325 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 108/295 (36%), Gaps = 32/295 (10%) Query: 163 DSMFFDRFLQWKWLERQPVTKNT----------------FRQYRVLGKGGFGEVCACQVR 206 ++++F L +P T +++G G GEVC ++R Sbjct: 12 ENLYFQGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLR 71 Query: 207 ATGKM---YACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVL 263 G+ A K L+ ++++ + L+E I+ + + ++ L +V Sbjct: 72 VPGQRDVPVAIKALKAGYTERQRRD--FLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVT 129 Query: 264 TIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG 323 M G L + F + + + G+ L V+RDL N+L+D Sbjct: 130 EYMENGSLDTFLRTHDGQ-FTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNL 188 Query: 324 HIRISDLGLAVKIPEG-DLIRGRVG---TVGYMAPEVLNNQRYGLSPDYWGLGCLIYE-M 378 ++SD GL+ + + D G + + APE + + + + D W G +++E + Sbjct: 189 VCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVL 248 Query: 379 IEGQSPFRGRKEKVKREEVDRRV-LETEEVYSHKFSEEAKSICKMLLTKDAKQRL 432 G+ P+ + V+ L H + + KD QR Sbjct: 249 AYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQ----LMLDCWHKDRAQRP 299 >5U6B-A nrPDB Length = 307 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 117/290 (40%), Gaps = 21/290 (7%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG--KMYACKRLEKK 220 +S+ L+ K L V ++ + LG+G FG V Q+ A K ++ Sbjct: 3 NSLGISEELKEK-LRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIA 61 Query: 221 RIKKRKGESMALNEKQILEKVNSQFVVNLAYAY------ETKDALCLVLTIMNGGDLKFH 274 + + E L+E +++ + V+ L E+ A ++L M GDL Sbjct: 62 ICTRSELED-FLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSF 120 Query: 275 IYNMG----NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDL 330 + + + + A+I G+E L + ++RDL N +L++ + ++D Sbjct: 121 LLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADF 180 Query: 331 GLAVKIPEGDLIR-GRVG--TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFR 386 GL+ KI GD R GR+ V ++A E L ++ Y D W G ++E+ GQ+P+ Sbjct: 181 GLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP 240 Query: 387 GRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 G + + + + + ++ + + R E Sbjct: 241 GVENSEIYDYLRQGNR---LKQPADCLDGLYALMSRCWELNPQDRPSFTE 287 >3OMV-A nrPDB Length = 307 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 61/263 (23%), Positives = 114/263 (43%), Gaps = 15/263 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G G FG V + A K L+ + ++ NE +L K ++ L Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQA-FRNEVAVLRKTRHVNIL-LFM 98 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 Y TKD L +V G L H++ + F+ + + A + G++ LH +N ++RD Sbjct: 99 GYMTKDNLAIVTQWCEGSSLYKHLH-VQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRD 157 Query: 312 LKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMAPEVLN---NQRYGLS 365 +K NI L + ++I D GLA + + G+V +MAPEV+ N + Sbjct: 158 MKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ 217 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV--YSHKFSEEAKSICKML 423 D + G ++YE++ G+ P+ + + + R + ++ + K + Sbjct: 218 SDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADC 277 Query: 424 LTKDAKQR-LGCQEEGAAEVKRH 445 + K ++R L Q + E+ +H Sbjct: 278 VKKVKEERPLFPQILSSIELLQH 300 >3N9X-A nrPDB Length = 432 Score = 220 bits (562), Expect = 1e-57, Method: Composition-based stats. Identities = 71/390 (18%), Positives = 131/390 (33%), Gaps = 103/390 (26%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F + V + + ++G+G +G V + T K A K++ + Sbjct: 12 ENLYFQGI------KNVHVP-DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNR-MF 63 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKD-----ALCLVLTIMNGGDLKFHIYN 277 + L E IL ++ S +++ L D L +VL I + DLK Sbjct: 64 EDLIDCKRILREITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKT 122 Query: 278 MGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP 337 EE +L G +H ++RDLKP N LL+ +++ D GLA I Sbjct: 123 --PIFLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTIN 180 Query: 338 EG-----------------------DLIRGRVGTVGYMAPE-VLNNQRYGLSPDYWGLGC 373 + V T Y APE +L + Y S D W GC Sbjct: 181 SEKDTNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGC 240 Query: 374 LIYEMI-----------EGQSPFRGR---------------------------------K 389 + E++ F G Sbjct: 241 IFAELLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPT 300 Query: 390 EKVKREEVDRRVLETEEVYSHK-----------FSEEAKSICKMLLTKDAKQRLGCQEEG 438 E + V++ +++ H+ S++ ++ + +L + +R+ Sbjct: 301 EDDLKNINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITI---- 356 Query: 439 AAEVKRHPFFRNMNFKRLEA---GMLDPPF 465 + HP+ +++ K+LE + PF Sbjct: 357 -DQALDHPYLKDVRKKKLENFSTKKIILPF 385 >5O2B-A nrPDB Length = 285 Score = 220 bits (562), Expect = 1e-57, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 116/266 (43%), Gaps = 22/266 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G F V T A L+ +++ K + + E ++L+ + +V Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE-QQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 252 AYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE-- 305 ++E+ K + LV +M G LK ++ + + + +IL GL+ LH Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRF--KVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 306 NTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 ++RDLK +NI + G ++I DLGLA + + +GT +MAPE+ + Y Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LMRTSFAKSVIGTPEFMAPEMY-EEHYDE 198 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET--EEVYSHKFSEEAKSICKM 422 S D + G + EM + P+ E ++ R+V ++ E K I + Sbjct: 199 SVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEG 255 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFF 448 + ++ +RL + ++ H FF Sbjct: 256 CIRQNKSERLSIR-----DLLNHAFF 276 >4KIK-B nrPDB Length = 677 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 85/306 (27%), Positives = 133/306 (43%), Gaps = 20/306 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 + LG GGFG V + TG+ A K+ ++ + R E L E QI+ ++ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCL-EIQIMRRLTHPN 78 Query: 246 VVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCG 298 VV E L L + GGDL+ ++ N G E L ++I Sbjct: 79 VVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASA 138 Query: 299 LEDLHRENTVYRDLKPENILL--DDYGHI-RISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 L LH ++RDLKPENI+L + I +I DLG A ++ +G L VGT+ Y+APE Sbjct: 139 LRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPE 198 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 +L Q+Y ++ DYW G L +E I G PF + V+ R+ E + V S + Sbjct: 199 LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGT 258 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCK 475 K L + A +++ + + M DP + P+ Sbjct: 259 VK-FSSSLPYPN-----NLNSVLAERLEK--WLQLMLMWHPRQRGTDPTYGPNGCFKALD 310 Query: 476 DVLDIE 481 D+L+++ Sbjct: 311 DILNLK 316 >5O2C-A nrPDB Length = 380 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 78/341 (22%), Positives = 141/341 (41%), Gaps = 28/341 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G F V T A L+ +++ K + + E ++L+ + +V Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE-QQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 252 AYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE-- 305 ++E+ K + LV +M G LK ++ + + + +IL GL+ LH Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRF--KVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 306 NTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 ++RDLK +NI + G ++I DLGLA + + +GT +MAPE+ + Y Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LMRTSFAKSVIGTPEFMAPEMY-EEHYDE 207 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET--EEVYSHKFSEEAKSICKM 422 S D + G + EM + P+ E ++ R+V ++ E K I + Sbjct: 208 SVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEG 264 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQ 482 + ++ +RL + ++ H FF R+E D D L +E Sbjct: 265 CIRQNKSERLSIR-----DLLNHAFFAEDTGLRVELAEED-----DCSNSSLALRLWVED 314 Query: 483 FSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKE 523 +KG + D+ +F T + EM+++ F E Sbjct: 315 PKKLKGKHKDNEAIEFSFNLETDT-PEEVAYEMVKSGFFHE 354 >3ORP-A nrPDB Length = 311 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 113/294 (38%), Gaps = 23/294 (7%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + + +LG GG EV + + A K L + E Q +N Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 244 QFVVNLAYAYETKDA----LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 +V + E + +V+ ++G L+ ++ G +RA+ A+ L Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGP--MTPKRAIEVIADACQAL 129 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG----DLIRGRVGTVGYMAPE 355 H+ ++RD+KP NI++ +++ D G+A I + +GT Y++PE Sbjct: 130 NFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE 189 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 D + LGC++YE++ G+ PF G + R S + Sbjct: 190 QARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSAD 249 Query: 416 AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDP 469 ++ L K+ + R + AAE++ + R+ G +PP P Sbjct: 250 LDAVVLKALAKNPENRY----QTAAEMR-------ADLVRVHNG--EPPEAPKV 290 >3NIE-A nrPDB Length = 429 Score = 220 bits (560), Expect = 2e-57, Method: Composition-based stats. Identities = 69/393 (17%), Positives = 133/393 (33%), Gaps = 104/393 (26%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F + ++ V + + ++G+G +G V + K A K++ + Sbjct: 12 ENLYFQGAI----IKNVKVP-DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNR-MF 65 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKD-----ALCLVLTIMNGGDLKFHIYN 277 + L E IL ++ S +++ L +D L +VL I + DLK Sbjct: 66 EDLIDCKRILREITILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKT 124 Query: 278 MGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP 337 E+ +L G + +H ++RDLKP N LL+ ++I D GLA I Sbjct: 125 --PIFLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTIN 182 Query: 338 EG--------------------------DLIRGRVGTVGYMAPE-VLNNQRYGLSPDYWG 370 + V T Y APE +L + Y S D W Sbjct: 183 SDKDIHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWS 242 Query: 371 LGCLIYEMI-----------EGQSPFRGRK------------------------------ 389 GC+ E++ F G Sbjct: 243 TGCIFAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIG 302 Query: 390 ---EKVKREEVDRRVLETEEVYS-----------HKFSEEAKSICKMLLTKDAKQRLGCQ 435 E+ + + V++ +++ S+E + + +L +A++R+ Sbjct: 303 TPPEEDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITID 362 Query: 436 EEGAAEVKRHPFFRNM---NFKRLEAGMLDPPF 465 + HP+ +++ N + + PF Sbjct: 363 K-----ALSHPYLKDVRKENLENFSTEKIILPF 390 >3PG1-A nrPDB Length = 362 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 69/314 (21%), Positives = 112/314 (35%), Gaps = 51/314 (16%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRL--------EKKRIKKRKGESMALNEKQI 237 + R + G +G VCA + G A KR+ + L E ++ Sbjct: 24 YTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 238 LEKVNSQFVVNLAYAYETKDA-----LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 L + ++ L + + L LV +M DL I++ + ++ Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQ-RIVISPQHIQYFM 140 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYM 352 IL GL LH V+RDL P NILL D I I D LA + V Y Sbjct: 141 YHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYR 200 Query: 353 APE-VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 APE V+ + + D W GC++ EM ++ FRG + ++ V + Sbjct: 201 APELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVM 260 Query: 412 FS----------------------------EEAKSICKMLLTKDAKQRLGCQEEGAAEVK 443 FS A + +L + ++R+ + Sbjct: 261 FSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRIST-----EQAL 315 Query: 444 RHPFFRNMNFKRLE 457 RHP+F ++ F L+ Sbjct: 316 RHPYFESL-FDPLD 328 >5HIE-A nrPDB Length = 302 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 108/272 (39%), Gaps = 19/272 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + + + +G G FG V + A K L ++++ NE Sbjct: 29 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQ------AFKNEVG 79 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 +L K ++ L Y TK L +V G L H++ + FE + + A + Sbjct: 80 VLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETK-FEMIKLIDIARQTA 137 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIRGRVGTVGYMA 353 G++ LH ++ ++RDLK NI L + ++I D GLA + G++ +MA Sbjct: 138 QGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMA 197 Query: 354 PEVLN---NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK-VKREEVDRRVLETEEVYS 409 PEV+ Y D + G ++YE++ GQ P+ + V R L + Sbjct: 198 PEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKV 257 Query: 410 HKFSEEA-KSICKMLLTKDAKQRLGCQEEGAA 440 +A K + L K +R + A+ Sbjct: 258 RSNCPKAMKRLMAECLKKKRDERPLFPQILAS 289 >5ZTN-A nrPDB Length = 429 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 62/246 (25%), Positives = 108/246 (43%), Gaps = 16/246 (6%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV--- 241 + +V+GKG FG+V + A K + ++ + A E +ILE + Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEK----RFHRQAAEEIRILEHLRKQ 153 Query: 242 ---NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 N+ V+++ + ++ +C+ +++ +L I GF +A IL Sbjct: 154 DKDNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQC 212 Query: 299 LEDLHRENTVYRDLKPENILLDDYGH--IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 L+ LH+ ++ DLKPENILL G I++ D G + E + + + Y APEV Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC--YEHQRVYTYIQSRFYRAPEV 270 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 + RYG+ D W LGC++ E++ G G E + + +L S+ A Sbjct: 271 ILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIE-LLGMPSQKLLDASKRA 329 Query: 417 KSICKM 422 K+ Sbjct: 330 KNFVSS 335 >2A1A-B nrPDB Length = 284 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 65/278 (23%), Positives = 118/278 (42%), Gaps = 40/278 (14%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F++ ++G GGFG+V + R GK Y KR++ K E + L K++ Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE-------REVKALAKLDHV 64 Query: 245 FVVNLAYAYETKDA----------------LCLVLTIMNGGDLKFHIYNMGNPGFEEERA 288 +V+ ++ D L + + + G L+ I ++ A Sbjct: 65 NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 124 Query: 289 LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT 348 L +I G++ +H + + RDLKP NI L D ++I D GL + GT Sbjct: 125 LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGT 184 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMI-EGQSPFRGRK-EKVKREEVDRRVLETEE 406 + YM+PE +++Q YG D + LG ++ E++ + F K R+ + + + +E Sbjct: 185 LRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKE 244 Query: 407 VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKR 444 K++ + LL+K + R +E+ R Sbjct: 245 ----------KTLLQKLLSKKPEDR-----PNTSEILR 267 >3E3P-A nrPDB Length = 360 Score = 218 bits (556), Expect = 5e-57, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 120/320 (37%), Gaps = 57/320 (17%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 ER + F+ R+ G+G FG V + ++TG A K++ + E Q Sbjct: 16 ERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVI-------QDPRFRNRELQ 68 Query: 237 ILEKV---NSQFVVNLAYAYE-----TKDALCL--VLTIMNGGDLKFHIYNMGNPGF--E 284 I++ + + +V L + + + L V+ + L N Sbjct: 69 IMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP-DTLHRCCRNYYRRQVAPP 127 Query: 285 EERALFYAAEILCGLEDLH--RENTVYRDLKPENILLDD-YGHIRISDLGLAVKIPEGDL 341 + +++ + LH N +RD+KP N+L+++ G +++ D G A K+ + Sbjct: 128 PILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEP 187 Query: 342 IRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400 + + Y APE++ Q Y + D W +GC+ EM+ G+ FRG + E+ R Sbjct: 188 NVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRV 247 Query: 401 VLETEEVYSHKFSE----------------------------EAKSICKMLLTKDAKQRL 432 + K + EA + LL ++R+ Sbjct: 248 LGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERM 307 Query: 433 GCQEEGAAEVKRHPFFRNMN 452 E HP+F ++ Sbjct: 308 KPY-----EALCHPYFDELH 322 >2W1I-A nrPDB Length = 326 Score = 218 bits (556), Expect = 5e-57, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 116/304 (38%), Gaps = 39/304 (12%) Query: 163 DSMFFDRFLQWKWLERQPVTKNT--FRQYRVLGKGGFGEVCACQVRA----TGKMYACKR 216 ++++F + + +R P + + LGKG FG V C+ TG++ A K+ Sbjct: 18 ENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKK 77 Query: 217 LEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYET--KDALCLVLTIMNGGDLKFH 274 L+ + E +IL+ + +V + + L L++ + G L+ + Sbjct: 78 LQHST---EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDY 134 Query: 275 IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV 334 + + + L Y ++I G+E L + ++RDL NIL+++ ++I D GL Sbjct: 135 LQKH-KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTK 193 Query: 335 KIPEGDLIRGRV----GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE 390 +P+ + + APE L ++ ++ D W G ++YE+ K Sbjct: 194 VLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT-----YIEKS 248 Query: 391 KVKREEVDRRVLETEE------------------VYSHKFSEEAKSICKMLLTKDAKQRL 432 K E R + ++ +E I + QR Sbjct: 249 KSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRP 308 Query: 433 GCQE 436 ++ Sbjct: 309 SFRD 312 >5HVK-A nrPDB Length = 315 Score = 217 bits (554), Expect = 7e-57, Method: Composition-based stats. Identities = 53/282 (18%), Positives = 104/282 (36%), Gaps = 27/282 (9%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 VLGKG FG+ R TG++ K L + + + L E +++ + Sbjct: 15 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRF---DEETQRTFLKEVKVMRCLEHP 71 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 V+ L + + GG L+ I +M + + + + +A +I G+ LH Sbjct: 72 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQ-YPWSQRVSFAKDIASGMAYLHS 130 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKI---------------PEGDLIRGRVGTV 349 N ++R+L N L+ + ++ ++D GLA + P+ VG Sbjct: 131 MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNP 190 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS 409 +MAPE++N + Y D + G ++ E+I + + ++ R + Sbjct: 191 YWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGF-LDRYCP 249 Query: 410 HKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 I D ++R + H + + Sbjct: 250 PNCPPSFFPITVRCCDLDPEKRPSFVK------LEH-WLETL 284 >3QA8-A nrPDB Length = 676 Score = 217 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 72/236 (30%), Positives = 110/236 (46%), Gaps = 13/236 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 + LG GGFG V + TG+ A K+ ++ + + E L E QI++K+N Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQC-RQELSPKNRERWCL-EIQIMKKLNHPN 73 Query: 246 VVNLAYA------YETKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCG 298 VV+ D L + GGDL+ ++ N G +E ++I Sbjct: 74 VVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSA 133 Query: 299 LEDLHRENTVYRDLKPENILLD---DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 L LH ++RDLKPENI+L +I DLG A ++ +G+L VGT+ Y+APE Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPE 193 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPF-RGRKEKVKREEVDRRVLETEEVYSH 410 +L ++Y ++ DYW G L +E I G PF + +V + E VY Sbjct: 194 LLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDD 249 >3LZB-A nrPDB Length = 327 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 102/260 (39%), Gaps = 15/260 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEK 240 F++ +VLG G FG V G+ A K L + K E L+E ++ Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAYVMAS 73 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 V++ V L T + L+ +M G L ++ + + L + +I G+ Sbjct: 74 VDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKD-NIGSQYLLNWCVQIAKGMN 131 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGYMAPEVL 357 L V+RDL N+L+ H++I+D GLA + + G + +MA E + Sbjct: 132 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 191 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 ++ Y D W G ++E++ G P+ G +++ + + Sbjct: 192 LHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG---ERLPQPPICTIDV 248 Query: 417 KSICKMLLTKDAKQRLGCQE 436 I + DA R +E Sbjct: 249 YMIMRKCWMIDADSRPKFRE 268 >3RP9-A nrPDB Length = 458 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 67/377 (17%), Positives = 121/377 (32%), Gaps = 103/377 (27%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 + + ++G G +G VC + ++ A K++ + + L E IL ++N Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI-LRVFEDLIDCKRILREIAILNRLNH 111 Query: 244 QFVVNLAYAY-----ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 VV + E D L +VL I + ++ E +L G Sbjct: 112 DHVVKVLDIVIPKDVEKFDELYVVLEIAD--SDFKKLFRT-PVYLTELHIKTLLYNLLVG 168 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD------------------ 340 ++ +H ++RDLKP N L++ +++ D GLA + + Sbjct: 169 VKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLV 228 Query: 341 ----------LIRGRVGTVGYMAPE-VLNNQRYGLSPDYWGLGCLIYEMIE--------- 380 + G V T Y APE +L + Y + D W +GC+ E++ Sbjct: 229 TFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYH 288 Query: 381 --GQSPFRGRK-------------------EKVKREEVDRRVLETE-------------- 405 F G + V +L T Sbjct: 289 ADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAK 348 Query: 406 ---------------EVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 E + S +A + K +L + +R+ E HPFF+ Sbjct: 349 RYIRIFPKREGTDLAERFPAS-SADAIHLLKRMLVFNPNKRITIN-----ECLAHPFFKE 402 Query: 451 MNFKRLEAGMLDPPFVP 467 + +E + +P Sbjct: 403 VRIAEVETNATEKVRLP 419 >5GNK-A nrPDB Length = 297 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 102/260 (39%), Gaps = 15/260 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEK 240 F++ +VLG G FG V G+ A K L + K E L+E ++ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAYVMAS 77 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 V++ V L T + L++ +M G L ++ + + L + +I G+ Sbjct: 78 VDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKD-NIGSQYLLNWCVQIAKGMN 135 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGYMAPEVL 357 L V+RDL N+L+ H++I+D GLA + + G + +MA E + Sbjct: 136 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 195 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 ++ Y D W G ++E++ G P+ G +++ + + Sbjct: 196 LHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG---ERLPQPPICTIDV 252 Query: 417 KSICKMLLTKDAKQRLGCQE 436 I DA R +E Sbjct: 253 YMIMVKCWMIDADSRPKFRE 272 >4YFF-A nrPDB Length = 311 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 58/258 (22%), Positives = 104/258 (40%), Gaps = 11/258 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + ++G G FG+V + R K+ A KR + M E IL ++N Sbjct: 43 EIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHP 100 Query: 245 FVVNLAYAYE-TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 V+ A +V ++GG L ++ + + L A ++ G+E LH Sbjct: 101 CVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKR-ILDLQSKLIIAVDVAKGMEYLH 159 Query: 304 R--ENTVYRDLKPENILLDDYGHIRISDLGLAVKIP--EGDLIRGRVGTVGYMAPEVLNN 359 + ++RDL NILL + GH ++D G + + + D + + G + +MAPEV Sbjct: 160 NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQ 219 Query: 360 -QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 RY + D + ++E++ G+ PF K ++ + YS + S Sbjct: 220 CTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS--IPKPISS 277 Query: 419 ICKMLLTKDAKQRLGCQE 436 + + R E Sbjct: 278 LLIRGWNACPEGRPEFSE 295 >5HLW-A nrPDB Length = 299 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 107/259 (41%), Gaps = 20/259 (7%) Query: 190 RVLGKGGFGEVCACQVRA-TGKMY--ACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 V+G+G FG V + GK A K L RI S L E I++ + V Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEVSQFLTEGIIMKDFSHPNV 83 Query: 247 VNLAYAY-ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++L ++ + +VL M GDL+ I N + + + + ++ G++ L + Sbjct: 84 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLASK 142 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI-----RGRVGTVGYMAPEVLNNQ 360 V+RDL N +LD+ ++++D GLA + + + G V +MA E L Q Sbjct: 143 KFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQ 202 Query: 361 RYGLSPDYWGLGCLIYEMIE-GQSPFRGRK--EKVKREEVDRRVLETEEVYSHKFSEEAK 417 ++ D W G L++E++ G P+ + RR+L+ E + Sbjct: 203 KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY-----CPDPLY 257 Query: 418 SICKMLLTKDAKQRLGCQE 436 + A+ R E Sbjct: 258 EVMLKCWHPKAEMRPSFSE 276 >6CTH-A nrPDB Length = 309 Score = 215 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 59/219 (26%), Positives = 97/219 (44%), Gaps = 10/219 (4%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGE 228 ++ E VT N F LG+GGFG V +R + A K++ + ++G Sbjct: 1 SMRKFSLNELAKVTSN-FNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRA---SKQGI 56 Query: 229 SMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA 288 +E +I+ ++ + +V L + L LV M G L HI+ G E Sbjct: 57 KEYASEVKIISRLRHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFK-GKSLLTWEVR 115 Query: 289 LFYAAEILCGLEDLHREN---TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG- 344 ++ L LH E ++RD+K NI+LD + ++ D GLA + ++ Sbjct: 116 YRIVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKT 175 Query: 345 -RVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQ 382 GTVGYMAPE L++ + D + G + E+ G+ Sbjct: 176 LLAGTVGYMAPECLSSGKASKESDVYSFGVVALEIASGR 214 >6J5U-C nrPDB Length = 426 Score = 215 bits (548), Expect = 4e-56, Method: Composition-based stats. Identities = 82/301 (27%), Positives = 123/301 (40%), Gaps = 44/301 (14%) Query: 170 FLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRAT---------GKMYACKRLEKK 220 + + E + TKN FRQ +LG+GGFG V + T G + A K+L+ + Sbjct: 71 LKAFTFNELKNATKN-FRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPE 129 Query: 221 RIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN 280 + G L E L +++ +V L + LV M G L+ H++ G Sbjct: 130 GFQ---GHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGA 186 Query: 281 PGFEEERALFYAAEILCGLEDLHREN--TVYRDLKPENILLDDYGHIRISDLGLAVKIPE 338 + A GL LH +YRD K NILLD + ++SD GLA P Sbjct: 187 QPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPT 246 Query: 339 GDLI---RGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQ------------- 382 GD +GT GY APE + R D + G ++ E+I G+ Sbjct: 247 GDNTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYS 306 Query: 383 -----SPFRGRKEKVKREEVDRRVLETEE--VYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 +P+ G K K+ R+++T+ Y K + A ++ L DAK R Sbjct: 307 LVDWATPYLGDKRKL------FRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMS 360 Query: 436 E 436 E Sbjct: 361 E 361 >3PP0-A nrPDB Length = 338 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 59/260 (22%), Positives = 102/260 (39%), Gaps = 15/260 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEK 240 R+ +VLG G FG V G+ A K L + K E L+E ++ Sbjct: 18 ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKE--ILDEAYVMAG 75 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 V S +V L T + LV +M G L H+ + L + +I G+ Sbjct: 76 VGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGR-LGSQDLLNWCMQIAKGMS 133 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGYMAPEVL 357 L V+RDL N+L+ H++I+D GLA + + G + +MA E + Sbjct: 134 YLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESI 193 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 +R+ D W G ++E++ G P+ G + + +++ + + Sbjct: 194 LRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKG---ERLPQPPICTIDV 250 Query: 417 KSICKMLLTKDAKQRLGCQE 436 I D++ R +E Sbjct: 251 YMIMVKCWMIDSECRPRFRE 270 >3UIU-A nrPDB Length = 306 Score = 214 bits (545), Expect = 1e-55, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 119/291 (40%), Gaps = 53/291 (18%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F++ ++G GGFG+V + R GK Y +R++ K E + L K++ Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAE-------REVKALAKLDHV 65 Query: 245 FVVNLAYAYETKDA-----------------------------LCLVLTIMNGGDLKFHI 275 +V+ ++ D L + + + G L+ I Sbjct: 66 NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWI 125 Query: 276 YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 ++ AL +I G++ +H + ++RDLKP NI L D ++I D GL Sbjct: 126 EKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS 185 Query: 336 IPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMI-EGQSPFRGRK-EKVK 393 + GT+ YM+PE +++Q YG D + LG ++ E++ + F K Sbjct: 186 LKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDL 245 Query: 394 REEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKR 444 R+ + + + +E K++ + LL+K + R +E+ R Sbjct: 246 RDGIISDIFDKKE----------KTLLQKLLSKKPEDR-----PNTSEILR 281 >5X8I-B nrPDB Length = 346 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 68/335 (20%), Positives = 112/335 (33%), Gaps = 78/335 (23%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQ-VRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 V + LG+G FG+V C +A G+ A K ++ + A +E Q+L Sbjct: 9 DVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK----NVDRYCEAARSEIQVL 64 Query: 239 EKVN--SQF----VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 E +N V + +E +C+V ++ G I G F + A Sbjct: 65 EHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMA 123 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDD-------------------YGHIRISDLGLA 333 +I + LH + DLKPENIL I++ D G A Sbjct: 124 YQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA 183 Query: 334 VKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV- 392 + + V T Y APEV+ + D W +GC++ E G + F K Sbjct: 184 T--YDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 393 ---------------KREEVDRRVLETEEVYSHKFS------------------------ 413 ++ R+ + + + S Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEH 301 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 E + + +L D +R+ + E +HPFF Sbjct: 302 ERLFDLIQKMLEYDPAKRITLR-----EALKHPFF 331 >3IO7-A nrPDB Length = 313 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 107/282 (37%), Gaps = 37/282 (13%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRA----TGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + + + LGKG FG V C+ TG++ A K+L+ + E +IL Sbjct: 27 ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST---EEHLRDFEREIEIL 83 Query: 239 EKVNSQFVVNLAYAYET--KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 + + +V + + L L++ + G L+ ++ + + L Y ++I Sbjct: 84 KSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH-KERIDHIKLLQYTSQIC 142 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRV----GTVGYM 352 G+E L + ++RDL NIL+++ ++I D GL +P+ + + Sbjct: 143 KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY 202 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEE------ 406 APE L ++ ++ D W G ++YE+ K K E R + ++ Sbjct: 203 APESLTESKFSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGNDKQGQMIVF 257 Query: 407 ------------VYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 +E I + QR ++ Sbjct: 258 HLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRD 299 >6DBN-A nrPDB Length = 316 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 106/282 (37%), Gaps = 25/282 (8%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRA----TGKMYACKRLEKKRIKKRKGESMA 231 ++ K ++ R LG+G FG+V C+ TG+ A K L+ + + Sbjct: 27 VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPE--SGGNHIADL 84 Query: 232 LNEKQILEKVNSQFVVNLAYAYETK--DALCLVLTIMNGGDLKFHIYNMGNPGFEEERAL 289 E +IL + + +V + + L++ + G LK ++ N ++ L Sbjct: 85 KKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK-INLKQQL 143 Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG----R 345 YA +I G++ L V+RDL N+L++ ++I D GL I R Sbjct: 144 KYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDR 203 Query: 346 VGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE----GQSP---FRGRKEKVKREEVD 398 V + APE L ++ ++ D W G ++E++ SP F + Sbjct: 204 DSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTV 263 Query: 399 RRVLET-----EEVYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 R++ T +E + + R Q Sbjct: 264 TRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQ 305 >3C1X-A nrPDB Length = 373 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 62/259 (23%), Positives = 109/259 (42%), Gaps = 20/259 (7%) Query: 190 RVLGKGGFGEVCACQVRA-TGKMY--ACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 V+G+G FG V + GK A K L RI S L E I++ + V Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEVSQFLTEGIIMKDFSHPNV 152 Query: 247 VNLAYAY-ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 ++L ++ + +VL M GDL+ I N + + + + ++ G++ L + Sbjct: 153 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKFLASK 211 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG--DLIRGRVG---TVGYMAPEVLNNQ 360 V+RDL N +LD+ ++++D GLA + + D + + G V +MA E L Q Sbjct: 212 KFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQ 271 Query: 361 RYGLSPDYWGLGCLIYEMIE-GQSPFRGRK--EKVKREEVDRRVLETEEVYSHKFSEEAK 417 ++ D W G L++E++ G P+ + RR+L+ E + Sbjct: 272 KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY-----CPDPLY 326 Query: 418 SICKMLLTKDAKQRLGCQE 436 + A+ R E Sbjct: 327 EVMLKCWHPKAEMRPSFSE 345 >1U59-A nrPDB Length = 287 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 55/248 (22%), Positives = 100/248 (40%), Gaps = 14/248 (5%) Query: 192 LGKGGFGEVCACQVRATGKM--YACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 LG G FG V R K A K L++ K E + E QI+ ++++ ++V L Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE--MMREAQIMHQLDNPYIVRL 75 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 + +AL LV+ + GG L + ++ G++ L +N V+ Sbjct: 76 IGVCQ-AEALMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG----TVGYMAPEVLNNQRYGLS 365 RDL N+LL + + +ISD GL+ + D + + APE +N +++ Sbjct: 134 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 193 Query: 366 PDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLL 424 D W G ++E + GQ P++ K +++ + E ++ Sbjct: 194 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---ECPPECPPELYALMSDCW 250 Query: 425 TKDAKQRL 432 + R Sbjct: 251 IYKWEDRP 258 >4TPT-A nrPDB Length = 303 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 55/281 (19%), Positives = 104/281 (37%), Gaps = 28/281 (9%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 VLGKG FG+ +ATGK+ K L + + + L E +++ ++ Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRC---DEETQKTFLTEVKVMRSLDHP 57 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 V+ L L+ + GG LK + +M F ++ + +A I G+ LH Sbjct: 58 NVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM--DPFPWQQKVRFAKGIASGMAYLHS 115 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVKI---------------------PEGDLIR 343 ++RDL N L+ + ++D GL+ I + Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRY 175 Query: 344 GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 VG +MAPE+LN + Y + D + G ++ E+I + ++ ++ Sbjct: 176 TVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLF- 234 Query: 404 TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE-EGAAEVK 443 E+ + + + + R + E + E Sbjct: 235 WEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 275 >3PLS-A nrPDB Length = 298 Score = 212 bits (539), Expect = 5e-55, Method: Composition-based stats. Identities = 59/257 (22%), Positives = 98/257 (38%), Gaps = 18/257 (7%) Query: 190 RVLGKGGFGEVCACQVR---ATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 RV+GKG FG V + A K L RI + + L E ++ +N V Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS--RITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 247 VNLAYAYETKDAL-CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 + L + L ++L M GDL I + + + + ++ G+E L + Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNP-TVKDLISFGLQVARGMEYLAEQ 143 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI-----RGRVGTVGYMAPEVLNNQ 360 V+RDL N +LD+ ++++D GLA I + + R V + A E L Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 361 RYGLSPDYWGLGCLIYEMIE-GQSPFRGRKE-KVKREEVDRRVLETEEVYSHKFSEEAKS 418 R+ D W G L++E++ G P+R + R L E Sbjct: 204 RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSL----YQ 259 Query: 419 ICKMLLTKDAKQRLGCQ 435 + + D R + Sbjct: 260 VMQQCWEADPAVRPTFR 276 >5AP3-A nrPDB Length = 313 Score = 212 bits (539), Expect = 5e-55, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 121/304 (39%), Gaps = 39/304 (12%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F V + + +G GG +V ++YA K + + Sbjct: 16 ENLYFQSM---------SVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA 65 Query: 223 KKRKGESMALNEKQILEKV--NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN 280 + +S NE L K+ +S ++ L T + +V+ DL + Sbjct: 66 DNQTLDSY-RNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKK--K 121 Query: 281 PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD 340 + Y +L + +H+ V+ DLKP N L+ D G +++ D G+A ++ Sbjct: 122 KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDT 180 Query: 341 L---IRGRVGTVGYMAPEVLNNQRYGLS-----------PDYWGLGCLIYEMIEGQSPFR 386 +VGTV YM PE + + D W LGC++Y M G++PF+ Sbjct: 181 TSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 240 Query: 387 GRKEKVKREEVDRRVLETEEVYSHKFSE-EAKSICKMLLTKDAKQRLGCQEEGAAEVKRH 445 ++ ++ + E+ E + + + K L +D KQR+ E+ H Sbjct: 241 QIINQIS--KLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISI-----PELLAH 293 Query: 446 PFFR 449 P+ + Sbjct: 294 PYVQ 297 >5TOS-A nrPDB Length = 395 Score = 212 bits (539), Expect = 5e-55, Method: Composition-based stats. Identities = 77/296 (26%), Positives = 124/296 (41%), Gaps = 34/296 (11%) Query: 171 LQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVR---------ATGKMYACKRLEKKR 221 + + E + T+N FR V+G+GGFG V + TG + A K+L ++ Sbjct: 53 KSFTFNELKLATRN-FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 Query: 222 IKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN- 280 + G L E L +++ +V L + LV M G L+ H++ G Sbjct: 112 FQ---GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 Query: 281 -PGFEEERALFYAAEILCGLEDLHRE--NTVYRDLKPENILLDDYGHIRISDLGLAVKIP 337 + A + GL LH + +YRD+K NILLD + ++SD GLA P Sbjct: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 Query: 338 EGD--LIRGRV-GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKR 394 GD + RV GT GY APE +++ D + G L+ E++ G+ + + Sbjct: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 Query: 395 EEVD--RRVLETE---------EVYSHKFSEEAK---SICKMLLTKDAKQRLGCQE 436 VD R L ++ + + EEA S+ L+ + K R + Sbjct: 289 NLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 >6FYV-A nrPDB Length = 337 Score = 211 bits (538), Expect = 5e-55, Method: Composition-based stats. Identities = 67/335 (20%), Positives = 112/335 (33%), Gaps = 78/335 (23%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRA-TGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 V + + LG+G FG+V C G A K ++ + A +E Q+L Sbjct: 10 DVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVG----RYREAARSEIQVL 65 Query: 239 EKVNS--QF----VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 E +NS V + ++ +C+V ++ G I F+ + A Sbjct: 66 EHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMA 124 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDD-------------------YGHIRISDLGLA 333 +I + LH + DLKPENIL I++ D G A Sbjct: 125 YQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA 184 Query: 334 VKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV- 392 + + V T Y APEV+ + D W +GC++ E G + F+ K Sbjct: 185 T--YDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEH 242 Query: 393 ---------------KREEVDRRVLETEEVYSHKFS------------------------ 413 ++ R+ ++ + S Sbjct: 243 LAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEH 302 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 E+ + + +L D QR+ E +HPFF Sbjct: 303 EKLFDLVRRMLEYDPTQRITL-----DEALQHPFF 332 >3AOX-A nrPDB Length = 344 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 62/273 (22%), Positives = 91/273 (33%), Gaps = 22/273 (8%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQ-----VRATGKMYACKRLEKKRIKKRKGESMA 231 + + V + R LG G FGEV Q + A K L + + E Sbjct: 40 DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP--EVCSEQDELDF 97 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG-----FEEE 286 L E I+ K N Q +V ++L +M GGDLK + Sbjct: 98 LMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAML 157 Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG---HIRISDLGLAVKIPEGDLIR 343 L A +I CG + L + ++RD+ N LL G +I D G+A I R Sbjct: 158 DLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYR 217 Query: 344 -GRVG--TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDR 399 G V +M PE + D W G L++E+ G P+ + + E V Sbjct: 218 KGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTS 277 Query: 400 RVLETEEVYSHKFSEEAKSICKMLLTKDAKQRL 432 I + R Sbjct: 278 GGRMDP---PKNCPGPVYRIMTQCWQHQPEDRP 307 >4HVI-A nrPDB Length = 314 Score = 211 bits (537), Expect = 7e-55, Method: Composition-based stats. Identities = 66/279 (23%), Positives = 107/279 (38%), Gaps = 28/279 (10%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRA----TGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + + LGKG FG V C+ TG + A K+L+ + E QIL Sbjct: 9 ERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS---GPDQQRDFQREIQIL 65 Query: 239 EKVNSQFVVNLAYAYETKDA--LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 + ++S F+V L LV+ + G L+ + + R L Y+++I Sbjct: 66 KALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL-QRHRARLDASRLLLYSSQIC 124 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRV---GTVGYM 352 G+E L V+RDL NIL++ H++I+D GLA +P + D R + + Sbjct: 125 KGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY 184 Query: 353 APEVLNNQRYGLSPDYWGLGCLIYEMIE----GQSPFRGRKEKVKREEVDRRVLETEE-- 406 APE L++ + D W G ++YE+ SP ++ E D L Sbjct: 185 APESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSP-SAEFLRMMGSERDVPALSRLLEL 243 Query: 407 -------VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEG 438 E + K+ + R G Sbjct: 244 LEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALG 282 >6GVJ-A nrPDB Length = 429 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 116/286 (40%), Gaps = 30/286 (10%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V + + +G GG +V ++YA K + + + +S NE L K Sbjct: 141 VKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSY-RNEIAYLNK 198 Query: 241 V--NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + +S ++ L T + +V+ DL + + Y +L Sbjct: 199 LQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 255 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL---IRGRVGTVGYMAPE 355 + +H+ V+ DLKP N L+ D G +++ D G+A ++ +VGTV YM PE Sbjct: 256 VHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 314 Query: 356 VLNNQRYGLS-----------PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 + + D W LGC++Y M G++PF+ ++ ++ + Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQIS--KLHAIIDPN 372 Query: 405 EEVYSHKFSE-EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 E+ E + + + K L +D KQR+ E+ HP+ + Sbjct: 373 HEIEFPDIPEKDLQDVLKCCLKRDPKQRISI-----PELLAHPYVQ 413 >5O0Y-A nrPDB Length = 579 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 62/264 (23%), Positives = 107/264 (40%), Gaps = 26/264 (9%) Query: 197 FGEVCACQVRATGKMYACKR--LEK--KRIKKRKGESMALNEKQILEKVNSQFVVNLAYA 252 F EV + A K L K + KK A E +I ++++ +V L Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 253 Y-ETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN--TVY 309 + D+ C VL G DL F++ + E+ A +I+ L+ L+ ++ Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQ--HKLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 310 RDLKPENILLDDY---GHIRISDLGLAVKIPEGDL--------IRGRVGTVGYMAPEVL- 357 DLKP NILL + G I+I+D GL+ + + GT Y+ PE Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 358 ---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK--F 412 + D W +G + Y+ + G+ PF + + + + + TE + K Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVV 534 Query: 413 SEEAKSICKMLLTKDAKQRLGCQE 436 + EAK+ + L + R+ Q+ Sbjct: 535 TPEAKAFIRRCLAYRKEDRIDVQQ 558 >4Y83-A nrPDB Length = 332 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 62/318 (19%), Positives = 117/318 (36%), Gaps = 33/318 (10%) Query: 142 FSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQ-----YRVLG--- 193 F+ + ++ G +S + R + + YR +G Sbjct: 24 FANHISNTAKHFYG---QRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDF 80 Query: 194 --KGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 +G FG+V Q T K ACK + + K +I + + L Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD--------VEIQACFRHENIAELYG 132 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 A + + L + GG + + + G E ++ +L GL+ LH + ++ D Sbjct: 133 AVLWGETVHLFMEAGEGGSVLEKLESCGPMR--EFEIIWVTKHVLKGLDFLHSKKVIHHD 190 Query: 312 LKPENILLDDYGHIRISDLGLAVKIPEGDLI-RGRVGTVGYMAPEVLNNQRYGLSPDYWG 370 +KP NI+ + + D GL+V++ E + GT YM+PEV+ + + D + Sbjct: 191 IKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYS 249 Query: 371 LGCLIYEMIEGQSPF---RGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKD 427 LG + M G P+ R + + E + S + + + L ++ Sbjct: 250 LGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERN 309 Query: 428 AKQRLGCQEEGAAEVKRH 445 R AA++ +H Sbjct: 310 PNHR-----PRAADLLKH 322 >3EB0-A nrPDB Length = 383 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 52/339 (15%), Positives = 110/339 (32%), Gaps = 80/339 (23%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 + + + LG G FG VC +GK +A K++ + E I++ Sbjct: 3 ETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV-------LQDPRYKNRELDIMK 55 Query: 240 KVNSQFVVNLAYAYET--------------------------------------KDALCL 261 ++ ++ L + T L + Sbjct: 56 VLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNV 115 Query: 262 VLTIMNGGDLKFHIYN--MGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL 319 ++ + L + + Y ++ + +H +RD+KP+N+L+ Sbjct: 116 IMEYVP-DTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLV 174 Query: 320 DD-YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYE 377 + +++ D G A K+ + + + Y APE++ Y S D W +GC+ E Sbjct: 175 NSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGE 234 Query: 378 MIEGQSPFRGRKEKVKREEVDR-------------------------RVLETEEVYSHKF 412 +I G+ F G + + + + + ++ Sbjct: 235 LILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGT 294 Query: 413 SEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 A + + +L + R+ E HPFF ++ Sbjct: 295 PSLAIDLLEQILRYEPDLRINPY-----EAMAHPFFDHL 328 >3HMP-A nrPDB Length = 342 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 116/286 (40%), Gaps = 30/286 (10%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V + + +G GG +V ++YA K + + + +S NE L K Sbjct: 53 VKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSY-RNEIAYLNK 110 Query: 241 V--NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + +S ++ L T + +V+ DL + + Y +L Sbjct: 111 LQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 167 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL---IRGRVGTVGYMAPE 355 + +H+ V+ DLKP N L+ D G +++ D G+A ++ +VGTV YM PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 226 Query: 356 VLNNQRYGLS-----------PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 + + D W LGC++Y M G++PF+ ++ ++ + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQIS--KLHAIIDPN 284 Query: 405 EEVYSHKFSE-EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 E+ E + + + K L +D KQR+ E+ HP+ + Sbjct: 285 HEIEFPDIPEKDLQDVLKCCLKRDPKQRISI-----PELLAHPYVQ 325 >6O6Q-A nrPDB Length = 335 Score = 209 bits (531), Expect = 4e-54, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 113/305 (37%), Gaps = 54/305 (17%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + R LG+G + EV + K L+ + KK E IL+ + Sbjct: 39 PQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKK------IKREISILKNL 92 Query: 242 -NSQFVVNLAYAYETKDA--LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + ++ + + L+ +N D + P F + FY E+L Sbjct: 93 VDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL-----YPTFTDYDIRFYMYELLKA 147 Query: 299 LEDLHRENTVYRDLKPENILLDDYGH-IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVL 357 L+ H ++RD+KP N+++D +R+ D GLA G RV + + PE+L Sbjct: 148 LDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELL 207 Query: 358 -NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE---------KVKREEVDRRVLE---- 403 + + Y S D W GC++ M+ + PF K +V + ++ LE Sbjct: 208 VDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNI 267 Query: 404 --------------------TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVK 443 E S+E + LL D ++RL A E Sbjct: 268 SLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLT-----AKEAM 322 Query: 444 RHPFF 448 +H +F Sbjct: 323 KHAYF 327 >4IDT-A nrPDB Length = 356 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 66/254 (25%), Positives = 107/254 (42%), Gaps = 18/254 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 LG+G FGEV + + TG A K++ + + E + S +V L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE--------ELMACAGLTSPRIVPLYG 133 Query: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 A + + + ++ GG L + G E+RAL+Y + L GLE LH ++ D Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGC--LPEDRALYYLGQALEGLEYLHSRRILHGD 191 Query: 312 LKPENILLDDYG-HIRISDLGLAVKIPEG----DLIRGRV--GTVGYMAPEVLNNQRYGL 364 +K +N+LL G H + D G AV + DL+ G GT +MAPEV+ + Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDA 251 Query: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLL 424 D W C++ M+ G P+ ++ E+ A++I + L Sbjct: 252 KVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEG-L 310 Query: 425 TKDAKQRLGCQEEG 438 K+ R+ E G Sbjct: 311 RKEPIHRVSAAELG 324 >4LRM-A nrPDB Length = 334 Score = 208 bits (530), Expect = 5e-54, Method: Composition-based stats. Identities = 57/263 (21%), Positives = 101/263 (38%), Gaps = 18/263 (6%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKRLEKKRIKKRKGESMALNEKQILEK 240 F++ +VLG G FG V G+ A K L + K E L+E ++ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAYVMAS 77 Query: 241 VNSQ---FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 V++ V L T + L+ +M G L ++ + + L + +I Sbjct: 78 VDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKD-NIGSQYLLNWCVQIAK 135 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG---TVGYMAP 354 G+ L V+RDL N+L+ H++I+D GLA + + G + +MA Sbjct: 136 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 195 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 E + ++ Y D W G ++E++ G P+ G +++ + Sbjct: 196 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKG---ERLPQPPICT 252 Query: 414 EEAKSICKMLLTKDAKQRLGCQE 436 + I DA R +E Sbjct: 253 IDVYMIMVKCWMIDADSRPKFRE 275 >2OZO-A nrPDB Length = 613 Score = 208 bits (530), Expect = 6e-54, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 100/248 (40%), Gaps = 14/248 (5%) Query: 192 LGKGGFGEVCACQVRATGKM--YACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 LG G FG V R K A K L++ K E + E QI+ ++++ ++V L Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE--MMREAQIMHQLDNPYIVRL 401 Query: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVY 309 + +AL LV+ + GG L + ++ G++ L +N V+ Sbjct: 402 IGVCQ-AEALMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 Query: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG----TVGYMAPEVLNNQRYGLS 365 R+L N+LL + + +ISD GL+ + D + + APE +N +++ Sbjct: 460 RNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 Query: 366 PDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLL 424 D W G ++E + GQ P++ K +++ + E ++ Sbjct: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---ECPPECPPELYALMSDCW 576 Query: 425 TKDAKQRL 432 + R Sbjct: 577 IYKWEDRP 584 >2WO6-A nrPDB Length = 382 Score = 208 bits (529), Expect = 6e-54, Method: Composition-based stats. Identities = 63/249 (25%), Positives = 115/249 (46%), Gaps = 14/249 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE-KKRIKKRKGESMALNEKQILEKV 241 + + ++GKG FG+V R + A K ++ KK + + L E ++ K Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLE--LMNKH 110 Query: 242 NSQ---FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 +++ ++V+L + ++ LCLV +++ +L + N G +A ++ Sbjct: 111 DTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMCTA 169 Query: 299 LEDLH--RENTVYRDLKPENILLDD--YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAP 354 L L + ++ DLKPENILL + I+I D G + ++ G I + + Y +P Sbjct: 170 LLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFYRSP 227 Query: 355 EVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSE 414 EVL Y L+ D W LGC++ EM G+ F G E + ++ VL + + Sbjct: 228 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVE-VLGIPPAHILDQAP 286 Query: 415 EAKSICKML 423 +A+ + L Sbjct: 287 KARKFFEKL 295 Score = 38.0 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 14/36 (38%), Gaps = 5/36 (13%) Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + K + +L D K R+ +H FF+ Sbjct: 348 KFKDLILRMLDYDPKTRIQPYY-----ALQHSFFKK 378 >4JLC-A nrPDB Length = 657 Score = 207 bits (528), Expect = 8e-54, Method: Composition-based stats. Identities = 53/243 (21%), Positives = 103/243 (42%), Gaps = 17/243 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 Q + + + +LG+G V + + TG +YA K + + E ++L Sbjct: 3 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVL 60 Query: 239 EKVNSQFVVNLAYAYETKD--ALCLVLTIMNGGDLKFHIYNMGN-PGFEEERALFYAAEI 295 +K+N + +V L E L++ G L + N G E L ++ Sbjct: 61 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 120 Query: 296 LCGLEDLHRENTVYRDLKPENIL--LDDYGH--IRISDLGLAVKIPEGDLIRGRVGTVGY 351 + G+ L V+RD+KP NI+ + + G +++D G A ++ + + GT Y Sbjct: 121 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 180 Query: 352 MAPEVL--------NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 + P++ + ++YG + D W +G Y G PFR + + +EV +++ Sbjct: 181 LHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 240 Query: 404 TEE 406 + Sbjct: 241 GKP 243 >4OW8-A nrPDB Length = 283 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 100/265 (37%), Gaps = 12/265 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 +R R++ GG G+V G+ A K L+ + + E + +N Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 245 FVVNLAYAYE-----TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + ++ E LV+ ++NG L + G AL + L Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 129 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG--RVGTVGYMAPEVL 357 + H V+RD+KP NIL+ G ++I+D G+A + + + +GT Y+APE Sbjct: 130 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 189 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 + D + LG + YE + G+ PF G + + E + Sbjct: 190 LGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK---HIKEPPPPLPPDLPPNVR 246 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEV 442 + ++ L K+ R A V Sbjct: 247 ELIEITLVKNPAMRYRSGGPFADAV 271 >4X3F-A nrPDB Length = 337 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 100/265 (37%), Gaps = 12/265 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 +R R++ GG G+V G+ A K L+ + + E + +N Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 245 FVVNLAYAYE-----TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + ++ E LV+ ++NG L + G AL + L Sbjct: 73 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 130 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG--RVGTVGYMAPEVL 357 + H V+RD+KP NIL+ G ++I+D G+A + + + +GT Y+APE Sbjct: 131 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 190 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 + D + LG + YE + G+ PF G + + E + Sbjct: 191 LGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK---HIKEPPPPLPPDLPPNVR 247 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEV 442 + ++ L K+ R A V Sbjct: 248 ELIEITLVKNPAMRYRSGGPFADAV 272 >6B2Q-A nrPDB Length = 317 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 100/265 (37%), Gaps = 12/265 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 +R R++ GG G+V G+ A K L+ + + E + +N Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 245 FVVNLAYAYE-----TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + ++ E LV+ ++NG L + G AL + L Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 150 Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG--RVGTVGYMAPEVL 357 + H V+RD+KP NIL+ G ++I+D G+A + + + +GT Y+APE Sbjct: 151 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 210 Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 + D + LG + YE + G+ PF G + + E + Sbjct: 211 LGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK---HIKEPPPPLPPDLPPNVR 267 Query: 418 SICKMLLTKDAKQRLGCQEEGAAEV 442 + ++ L K+ R A V Sbjct: 268 ELIEITLVKNPAMRYRSGGPFADAV 292 >2ZMD-A nrPDB Length = 390 Score = 205 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 115/286 (40%), Gaps = 30/286 (10%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V + + +G GG +V ++YA K + + + +S NE L K Sbjct: 53 VKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSY-RNEIAYLNK 110 Query: 241 V--NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 + +S ++ L T + +V+ DL + + Y +L Sbjct: 111 LQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 167 Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL---IRGRVGTVGYMAPE 355 + +H+ V+ DLKP N L+ D G +++ D G+A ++ +VG V YM PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPE 226 Query: 356 VLNNQRYGLS-----------PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 + + D W LGC++Y M G++PF+ ++ ++ + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQIS--KLHAIIDPN 284 Query: 405 EEVYSHKFSE-EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFR 449 E+ E + + + K L +D KQR+ E+ HP+ + Sbjct: 285 HEIEFPDIPEKDLQDVLKCCLKRDPKQRISI-----PELLAHPYVQ 325 >4EUU-A nrPDB Length = 319 Score = 205 bits (523), Expect = 4e-53, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 106/246 (43%), Gaps = 17/246 (6%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 + Q + + + +LG+G V + + TG ++A K I + + + E Sbjct: 1 MGSQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREF 58 Query: 236 QILEKVNSQFVVNLAYAYETKD--ALCLVLTIMNGGDLKFHIYNMGN-PGFEEERALFYA 292 ++L+K+N + +V L E L++ G L + N G E L Sbjct: 59 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 118 Query: 293 AEILCGLEDLHRENTVYRDLKPENIL--LDDYGH--IRISDLGLAVKIPEGDLIRGRVGT 348 +++ G+ L V+R++KP NI+ + + G +++D G A ++ + + GT Sbjct: 119 RDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 178 Query: 349 VGYMAPEVL--------NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400 Y+ P++ + ++YG + D W +G Y G PFR + + +EV + Sbjct: 179 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 238 Query: 401 VLETEE 406 ++ + Sbjct: 239 IITGKP 244 >4EUT-A nrPDB Length = 396 Score = 205 bits (523), Expect = 4e-53, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 106/246 (43%), Gaps = 17/246 (6%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235 + Q + + + +LG+G V + + TG ++A K I + + + E Sbjct: 1 MGSQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREF 58 Query: 236 QILEKVNSQFVVNLAYAYETKD--ALCLVLTIMNGGDLKFHIYNMGN-PGFEEERALFYA 292 ++L+K+N + +V L E L++ G L + N G E L Sbjct: 59 EVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL 118 Query: 293 AEILCGLEDLHRENTVYRDLKPENIL--LDDYGH--IRISDLGLAVKIPEGDLIRGRVGT 348 +++ G+ L V+R++KP NI+ + + G +++D G A ++ + + GT Sbjct: 119 RDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT 178 Query: 349 VGYMAPEVL--------NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400 Y+ P++ + ++YG + D W +G Y G PFR + + +EV + Sbjct: 179 EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYK 238 Query: 401 VLETEE 406 ++ + Sbjct: 239 IITGKP 244 >3UIM-A nrPDB Length = 326 Score = 204 bits (520), Expect = 7e-53, Method: Composition-based stats. Identities = 61/224 (27%), Positives = 100/224 (44%), Gaps = 11/224 (4%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGE 228 + ++ E Q V + F +LG+GGFG+V ++ A G + A KRL+++R + GE Sbjct: 16 QLKRFSLRELQ-VASDNFSNKNILGRGGFGKVYKGRL-ADGTLVAVKRLKEERT--QGGE 71 Query: 229 SMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM--GNPGFEEE 286 E +++ + ++ L T LV M G + + P + Sbjct: 72 LQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWP 131 Query: 287 RALFYAAEILCGLEDLHRE---NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-- 341 + A GL LH ++RD+K NILLD+ + D GLA + D Sbjct: 132 KRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHV 191 Query: 342 IRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 GT+G++APE L+ + D +G G ++ E+I GQ F Sbjct: 192 TTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >4G3E-A nrPDB Length = 352 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 59/233 (25%), Positives = 100/233 (42%), Gaps = 30/233 (12%) Query: 160 EYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEK 219 + +D + + W+ QP G+G FGEV + + TG A K++ Sbjct: 63 KPVDYEYREEVH---WMTHQPRV----------GRGSFGEVHRMKDKQTGFQCAVKKVRL 109 Query: 220 KRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG 279 + + + E ++S +V L A + + + ++ GG L I MG Sbjct: 110 EVFR--------VEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMG 161 Query: 280 NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYG-HIRISDLGLAVKIPE 338 E+RAL+Y + L GLE LH ++ D+K +N+LL G + D G A+ + Sbjct: 162 C--LPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQP 219 Query: 339 GDLIRGRV------GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 L + + GT +MAPEV+ + D W C++ M+ G P+ Sbjct: 220 DGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPW 272 >5LPZ-A nrPDB Length = 332 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 97/234 (41%), Gaps = 21/234 (8%) Query: 159 HEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE 218 + L + F LQ N F ++G GGFG+V ++ G A K+L Sbjct: 1 EKPLRKLAFADLLQ---------ATNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLI 50 Query: 219 KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM 278 + G+ + E + + K+ + +V L + D LV M G L+ +++ Sbjct: 51 HVSGQ---GDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDP 107 Query: 279 GNPG--FEEERALFYAAEILCGLEDLH---RENTVYRDLKPENILLDDYGHIRISDLGLA 333 G A GL LH + ++RD+K N+LLD+ R+SD G+A Sbjct: 108 KKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMA 167 Query: 334 VKIPEGDL---IRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSP 384 + D + GT GY+ PE + R D + G ++ E++ G+ P Sbjct: 168 RLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >5LPV-A nrPDB Length = 296 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 97/234 (41%), Gaps = 21/234 (8%) Query: 159 HEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE 218 + L + F LQ N F ++G GGFG+V ++ G A K+L Sbjct: 1 EKPLRKLAFADLLQ---------ATNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLI 50 Query: 219 KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM 278 + G+ + E + + K+ + +V L + D LV M G L+ +++ Sbjct: 51 HVSGQ---GDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDP 107 Query: 279 GNPG--FEEERALFYAAEILCGLEDLH---RENTVYRDLKPENILLDDYGHIRISDLGLA 333 G A GL LH + ++RD+K N+LLD+ R+SD G+A Sbjct: 108 KKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMA 167 Query: 334 VKIPEGDL---IRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSP 384 + D + GT GY+ PE + R D + G ++ E++ G+ P Sbjct: 168 RLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >4C59-A nrPDB Length = 340 Score = 203 bits (517), Expect = 2e-52, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 108/280 (38%), Gaps = 38/280 (13%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-NS 243 R RVL +GGF V Q +G+ YA KRL +K + + E ++K+ Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA---IIQEVCFMKKLSGH 84 Query: 244 QFVVNLAYAYETKDA--------LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 +V A L+ + G ++F + L + Sbjct: 85 PNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQT 144 Query: 296 LCGLEDLHREN--TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR---------- 343 ++ +HR+ ++RDLK EN+LL + G I++ D G A I Sbjct: 145 CRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVE 204 Query: 344 ---GRVGTVGYMAPEVL---NNQRYGLSPDYWGLGCLIYEMIEGQSPFR-GRKEKVKREE 396 R T Y PE++ +N G D W LGC++Y + Q PF G K ++ + Sbjct: 205 EEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGK 264 Query: 397 VDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 +T+ H S+ + +L + ++RL E Sbjct: 265 YSIPPHDTQYTVFH-------SLIRAMLQVNPEERLSIAE 297 >6NT9-A nrPDB Length = 742 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 52/243 (21%), Positives = 105/243 (43%), Gaps = 17/243 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 Q + + + +LG+G V + + TG ++A K I + + + E ++L Sbjct: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMREFEVL 59 Query: 239 EKVNSQFVVNLAYAYETKD--ALCLVLTIMNGGDLKFHIYNMGN-PGFEEERALFYAAEI 295 +K+N + +V L E L++ G L + N G E L ++ Sbjct: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 Query: 296 LCGLEDLHRENTVYRDLKPENIL--LDDYGH--IRISDLGLAVKIPEGDLIRGRVGTVGY 351 + G+ L V+R++KP NI+ + + G +++D G A ++ + + GT Y Sbjct: 120 VGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 Query: 352 MAPEVL--------NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 + P++ + ++YG + D W +G Y G PFR + + +EV +++ Sbjct: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 Query: 404 TEE 406 + Sbjct: 240 GKP 242 >6O8B-A nrPDB Length = 665 Score = 202 bits (514), Expect = 3e-52, Method: Composition-based stats. Identities = 51/243 (20%), Positives = 103/243 (42%), Gaps = 17/243 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 Q + + + +LG+G V + + TG ++A K + + E ++L Sbjct: 10 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVL 67 Query: 239 EKVNSQFVVNLAYAYETKD--ALCLVLTIMNGGDLKFHIYNMGN-PGFEEERALFYAAEI 295 +K+N + +V L E L++ G L + N G E L ++ Sbjct: 68 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 127 Query: 296 LCGLEDLHRENTVYRDLKPENIL--LDDYGH--IRISDLGLAVKIPEGDLIRGRVGTVGY 351 + G+ L V+R++KP NI+ + + G +++D G A ++ + + GT Y Sbjct: 128 VGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEY 187 Query: 352 MAPEVL--------NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 + P++ + ++YG + D W +G Y G PFR + + +EV +++ Sbjct: 188 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 247 Query: 404 TEE 406 + Sbjct: 248 GKP 250 >4NEU-A nrPDB Length = 333 Score = 201 bits (512), Expect = 6e-52, Method: Composition-based stats. Identities = 65/271 (23%), Positives = 113/271 (41%), Gaps = 27/271 (9%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F + L GGFG+V C R G M K + K E+ L E +++ ++ Sbjct: 25 DFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEA-LLEEAKMMNRLRHS 82 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 VV L + LV+ M G+L + + + EI+ G+ LH Sbjct: 83 RVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVK--GRIILEIIEGMCYLHG 140 Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAV-------------KIPEGD-LIRGRVGTVG 350 + +++DLKPENIL+D+ HI+I+DLGLA ++ E D + GT+ Sbjct: 141 KGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLY 200 Query: 351 YMAPEVLN--NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY 408 YMAPE LN N + D + +++ + + P+ + + +++ + Sbjct: 201 YMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY---ENAICEQQLIMCIKSGNRPD 257 Query: 409 SHKFSE----EAKSICKMLLTKDAKQRLGCQ 435 +E E S+ K+ + + R Sbjct: 258 VDDITEYCPREIISLMKLCWEANPEARPTFP 288 >4FL3-A nrPDB Length = 635 Score = 200 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 108/267 (40%), Gaps = 16/267 (5%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVR-ATGKMYACKRLEKKRIKKRKGESMALN 233 +L+R+ +T + LG G FG V + ++ K + L Sbjct: 364 YLDRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA 419 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 E +++++++ ++V + E + + LV+ + G L ++ N +++ + Sbjct: 420 EANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ--NRHVKDKNIIELVH 476 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG----TV 349 ++ G++ L N V+RDL N+LL + +ISD GL+ + + V Sbjct: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVY 408 + APE +N ++ D W G L++E GQ P+RG K +++ Sbjct: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG---C 593 Query: 409 SHKFSEEAKSICKMLLTKDAKQRLGCQ 435 E + + T D + R G Sbjct: 594 PAGCPREMYDLMNLCWTYDVENRPGFA 620 >4MD7-E nrPDB Length = 391 Score = 200 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 78/329 (23%), Positives = 122/329 (37%), Gaps = 64/329 (19%) Query: 159 HEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE 218 EY D + ++W ++ ++ R LG+G + EV + Sbjct: 21 REYWD--YESHVVEWG-------NQDDYQLVRKLGRGKYSEVFEAINITNNEK------V 65 Query: 219 KKRIKKRKGESMALNEKQILEKVNS-QFVVNLAYAYETK--DALCLVLTIMNGGDLKFHI 275 +I K + E +ILE + ++ LA + LV +N D K Sbjct: 66 VVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL- 124 Query: 276 YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAV 334 + FY EIL L+ H ++RD+KP N+++D ++ +R+ D GLA Sbjct: 125 ----YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE 180 Query: 335 KIPEGDLIRGRVGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVK 393 G RV + + PE+L + Q Y S D W LGC++ MI + PF + Sbjct: 181 FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD 240 Query: 394 REEVDRRVLETEEVYS----------------------------------HKFSEEAKSI 419 + +VL TE++Y H S EA Sbjct: 241 QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF 300 Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 LL D + RL A E HP+F Sbjct: 301 LDKLLRYDHQSRLT-----AREAMEHPYF 324 >5C26-A nrPDB Length = 299 Score = 200 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 114/285 (40%), Gaps = 19/285 (6%) Query: 160 EYLDSMFFDRFL---QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVR-ATGKMYACK 215 E +S + D + +L+R+ +T + LG G FG V + Sbjct: 4 EVYESPYADPEEIRPKEVYLDRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAV 59 Query: 216 RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275 ++ K + L E +++++++ ++V + E + + LV+ + G L ++ Sbjct: 60 KILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYL 118 Query: 276 YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK 335 N +++ + ++ G++ L N V+RDL N+LL + +ISD GL+ Sbjct: 119 QQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKA 176 Query: 336 IPEGDLIRGRVG----TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKE 390 + + V + APE +N ++ D W G L++E GQ P+RG K Sbjct: 177 LRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG 236 Query: 391 KVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 +++ E + + T D + R G Sbjct: 237 SEVTAMLEKGERMG---CPAGCPREMYDLMNLCWTYDVENRPGFA 278 >3ZZW-A nrPDB Length = 289 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 54/280 (19%), Positives = 109/280 (38%), Gaps = 30/280 (10%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRA-----TGKMYACKRLEKKRIKKRKGESMA 231 + + ++ + R LG+ FG+V + + A K L+ K + E Sbjct: 2 KLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREE--F 59 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG--------- 282 +E + ++ VV L L ++ + + GDL + Sbjct: 60 RHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDR 119 Query: 283 -----FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIP 337 E + A+I G+E L + V++DL N+L+ D +++ISDLGL ++ Sbjct: 120 TVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVY 179 Query: 338 EGDLIR---GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVK 393 D + + + +MAPE + ++ + D W G +++E+ G P+ G + Sbjct: 180 AADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDV 239 Query: 394 REEV-DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRL 432 E + +R+VL + ++ + +R Sbjct: 240 VEMIRNRQVLPCPDDCPAWV----YALMIECWNEFPSRRP 275 >2RIO-A nrPDB Length = 434 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 128/327 (39%), Gaps = 61/327 (18%) Query: 183 KNTFRQYRVLGKGGFG-EVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 KN ++LG G G V + G+ A KR+ +AL E ++L + Sbjct: 14 KNLVVSEKILGYGSSGTVVFQGSFQ--GRPVAVKRMLIDFC------DIALMEIKLLTES 65 Query: 242 N-SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY-----AAEI 295 + V+ + T L + L + N +L+ + + + Y +I Sbjct: 66 DDHPNVIRYYCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQI 124 Query: 296 LCGLEDLHRENTVYRDLKPENILLD-------------DYGHIRISDLGLAVKIPEGDL- 341 G+ LH ++RDLKP+NIL+ + I ISD GL K+ G Sbjct: 125 ASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSS 184 Query: 342 ----IRGRVGTVGYMAPEVLNN-------QRYGLSPDYWGLGCLIYEMIE-GQSPFRGRK 389 + GT G+ APE+L +R S D + +GC+ Y ++ G+ PF + Sbjct: 185 FRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKY 244 Query: 390 EKVKREEVDRRVLETEE---VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHP 446 + + R + +E ++ EA + ++ D +R A +V RHP Sbjct: 245 SRES--NIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKR-----PTAMKVLRHP 297 Query: 447 FF----RNMNF-----KRLEAGMLDPP 464 F + + F RLE DPP Sbjct: 298 LFWPKSKKLEFLLKVSDRLEIENRDPP 324 >3LLT-A nrPDB Length = 360 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 82/362 (22%), Positives = 124/362 (34%), Gaps = 88/362 (24%) Query: 163 DSMFF---DRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEK 219 ++++F D + + W ++ + N F R +G G FG V CQ K YA K + Sbjct: 12 ENLYFQGDDEIVHFSW-KKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR- 69 Query: 220 KRIKKRKGESMALNEKQILEKVNSQFV-----VNLAYAYETKDALCLVLTIMNGGDLKFH 274 +K A E IL+K+ + + V + D +CL+ + G L Sbjct: 70 ---NIKKYTRSAKIEADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEI 125 Query: 275 IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD------------- 321 I GF E Y EIL L L + + + DLKPENILLDD Sbjct: 126 ITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRV 185 Query: 322 ------------YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYW 369 I++ D G A + D + T Y APEV+ N + +S D W Sbjct: 186 TDGKKIQIYRTKSTGIKLIDFGCATF--KSDYHGSIINTRQYRAPEVILNLGWDVSSDMW 243 Query: 370 GLGCLIYEMIEGQSPFRGRKEKV---KREEVDRRVL-------------------ETEEV 407 GC++ E+ G FR + E + + + E + Sbjct: 244 SFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLA 303 Query: 408 YSHKFS--------------------EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPF 447 + S E +L D R AE+ +H F Sbjct: 304 WPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLR-----PSPAELLKHKF 358 Query: 448 FR 449 Sbjct: 359 LE 360 >6HMD-A nrPDB Length = 365 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 75/317 (23%), Positives = 118/317 (37%), Gaps = 57/317 (17%) Query: 173 WKWLERQPV--TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM 230 W + P ++ ++ R LG+G + EV + +I K + Sbjct: 40 WDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNER------VVVKILKPVKKKK 93 Query: 231 ALNEKQILEKVNSQ-FVVNLAYAYETK--DALCLVLTIMNGGDLKFHIYNMGNPGFEEER 287 E +ILE + ++ L + LV +N D K + Sbjct: 94 IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL-----YQILTDFD 148 Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPENILLDD-YGHIRISDLGLAVKIPEGDLIRGRV 346 FY E+L L+ H + ++RD+KP N+++D +R+ D GLA RV Sbjct: 149 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV 208 Query: 347 GTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE 405 + + PE+L + Q Y S D W LGC++ MI + PF ++ + +VL TE Sbjct: 209 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 268 Query: 406 EVY----------------------------------SHKFSEEAKSICKMLLTKDAKQR 431 E+Y H S EA + LL D +QR Sbjct: 269 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 328 Query: 432 LGCQEEGAAEVKRHPFF 448 L A E HP+F Sbjct: 329 LT-----AKEAMEHPYF 340 >5WNO-A nrPDB Length = 330 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 101/258 (39%), Gaps = 17/258 (6%) Query: 187 RQYRVLGKGGFGEVCAC-----QVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + LG G FG V A + + A K + + L E + ++ Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ----TDQSQTDEMLEEATNMFRL 80 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 ++ + D L +V G+L+ + + + Y +I G++ Sbjct: 81 RHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFL-KLHKENLGAREQVLYCYQIASGMQY 139 Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVG--TVGYMAPEVLN 358 L ++ V+RDL N+L+ + H+ I+D GL+ + + D I + G + ++A E+ + Sbjct: 140 LEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFS 199 Query: 359 NQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417 Y + D W G +E+I GQSP++G + ++ S++ Sbjct: 200 KHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQ---PPNCSQDLY 256 Query: 418 SICKMLLTKDAKQRLGCQ 435 D K R G + Sbjct: 257 QELLRCWMADPKSRPGFE 274 >2PVN-A nrPDB Length = 352 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 70/331 (21%), Positives = 121/331 (36%), Gaps = 62/331 (18%) Query: 159 HEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE 218 EY D + +QW ++ + R +G+G + EV + + Sbjct: 36 KEYWD--YEALTVQWG-------EQDDYEVVRKVGRGKYSEVFEGINVNNNE-----KCI 81 Query: 219 KKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETK--DALCLVLTIMNGGDLKFHIY 276 K +K K + + K + +V L + L+ +N D + Sbjct: 82 IKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTD-----F 136 Query: 277 NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH-IRISDLGLAVK 335 + P + +Y E+L L+ H + ++RD+KP N+++D +R+ D GLA Sbjct: 137 KVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEF 196 Query: 336 IPEGDLIRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSP-FRGRKEKVK 393 G RV + + PE+L + Q Y S D W LGC+ MI + P F G + Sbjct: 197 YHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQ 256 Query: 394 REEV--------------DRRVLETEEVYS-------------------HKFSEEAKSIC 420 ++ R+ ++ + H S EA Sbjct: 257 LVKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFL 316 Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 LL D ++RL A E HP+F+ + Sbjct: 317 DKLLRYDHQERLT-----ALEAMTHPYFQQV 342 >6EII-A nrPDB Length = 352 Score = 197 bits (502), Expect = 1e-50, Method: Composition-based stats. Identities = 75/323 (23%), Positives = 119/323 (36%), Gaps = 62/323 (19%) Query: 165 MFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKK 224 + ++W ++ ++ R LG+G + EV + +I K Sbjct: 48 DYESHVVEWG-------NQDDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILK 94 Query: 225 RKGESMALNEKQILEKVNS-QFVVNLAYAYETK--DALCLVLTIMNGGDLKFHIYNMGNP 281 + E +ILE + ++ LA + LV +N D K Sbjct: 95 PVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL-----YQ 149 Query: 282 GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGD 340 + FY EIL L+ H ++RD+KP N+++D ++ +R+ D GLA G Sbjct: 150 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 209 Query: 341 LIRGRVGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 RV + + PE+L + Q Y S D W LGC++ MI + PF + + Sbjct: 210 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 269 Query: 400 RVLETEEVYS----------------------------------HKFSEEAKSICKMLLT 425 +VL TE++Y H S EA LL Sbjct: 270 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 329 Query: 426 KDAKQRLGCQEEGAAEVKRHPFF 448 D + RL A E HP+F Sbjct: 330 YDHQSRLT-----AREAMEHPYF 347 >4F0G-A nrPDB Length = 287 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 103/263 (39%), Gaps = 18/263 (6%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRL----EKKRIKKRKGESMALNEKQIL 238 N + +GKGGFG V ++ + A K L + + + E I+ Sbjct: 18 DNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIM 77 Query: 239 EKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCG 298 +N +V L +V+ + GDL + + +P + L +I G Sbjct: 78 SNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHP-IKWSVKLRLMLDIALG 134 Query: 299 LEDLHREN--TVYRDLKPENILL---DDYGHI--RISDLGLAVKIPEGDLIRGRVGTVGY 351 +E + +N V+RDL+ NI L D+ + +++D GL+ + + G +G + Sbjct: 135 IEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS--VSGLLGNFQW 192 Query: 352 MAPEVL--NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS 409 MAPE + + Y D + ++Y ++ G+ PF + R Sbjct: 193 MAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIP 252 Query: 410 HKFSEEAKSICKMLLTKDAKQRL 432 +++ ++ + D K+R Sbjct: 253 EDCPPRLRNVIELCWSGDPKKRP 275 >5UNP-A nrPDB Length = 369 Score = 194 bits (494), Expect = 7e-50, Method: Composition-based stats. Identities = 71/350 (20%), Positives = 124/350 (35%), Gaps = 86/350 (24%) Query: 183 KNTFRQYRVLGKGGFGEVCACQ-VRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 + + LG+G FG V C R G A K ++ K + A E +LEK+ Sbjct: 33 QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK----NVEKYKEAARLEINVLEKI 88 Query: 242 N-----SQFV-VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 N ++ + V + ++ +C+ ++ G + + + + A ++ Sbjct: 89 NEKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQL 147 Query: 296 LCGLEDLHRENTVYRDLKPENILL---------------DDYGH----IRISDLGLAVKI 336 ++ LH + DLKPENIL D+ +R+ D G A Sbjct: 148 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF- 206 Query: 337 PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKV---- 392 + + V T Y APEV+ + D W +GC+I+E G + F+ + Sbjct: 207 -DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM 265 Query: 393 -----------------KREEVDRRVLETEE-------------VYSHKFSEEAK----- 417 K++ R L+ +E + EA+ Sbjct: 266 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQL 325 Query: 418 -SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFV 466 + + +L + +RL E +HPFF RL A +PP Sbjct: 326 FDLIESMLEYEPAKRLTLG-----EALQHPFF-----ARLRA---EPPNK 362 >2QKW-B nrPDB Length = 321 Score = 194 bits (494), Expect = 8e-50, Method: Composition-based stats. Identities = 58/229 (25%), Positives = 103/229 (44%), Gaps = 12/229 (5%) Query: 162 LDSMFFDRFLQWK--WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEK 219 L S + F ++ ++ + T N F ++G G FG+V +R G A KR Sbjct: 16 LSSSYLVPFESYRVPLVDLEEAT-NNFDHKFLIGHGVFGKVYKGVLR-DGAKVALKR--- 70 Query: 220 KRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY--N 277 + + +G E + L +V+L + ++ + L+ M G+LK H+Y + Sbjct: 71 RTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSD 130 Query: 278 MGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-- 335 + E+ L GL LH ++RD+K NILLD+ +I+D G++ K Sbjct: 131 LPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGT 190 Query: 336 -IPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQS 383 + + L GT+GY+ PE R D + G +++E++ +S Sbjct: 191 ELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVLCARS 239 >5XVU-A nrPDB Length = 332 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 74/321 (23%), Positives = 121/321 (37%), Gaps = 53/321 (16%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGE 228 + + LE Q N + + +G+G + EV + A K L+ + KK K E Sbjct: 16 EYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKKKKIKRE 75 Query: 229 SMALNEKQILEKVNSQFVVNLAYAYETK--DALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286 L ++ L + L+ +N D K P F ++ Sbjct: 76 IKILQNLN-----GGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL-----YPKFTDK 125 Query: 287 RALFYAAEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGR 345 +Y +IL L+ H + ++RD+KP NI++D + IR+ GLA G R Sbjct: 126 DIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVR 185 Query: 346 VGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 V + Y PE+L + Q Y S D W LGC++ MI + PF + + +VL T Sbjct: 186 VASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGT 245 Query: 405 EE--------------------------VYSHKFS--------EEAKSICKMLLTKDAKQ 430 E+ +SH + +E + +L D + Sbjct: 246 EDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAK 305 Query: 431 RLGCQEEGAAEVKRHPFFRNM 451 R+ E HP+FR + Sbjct: 306 RIAP-----KEAMEHPYFREV 321 >3RAW-A nrPDB Length = 381 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 65/367 (17%), Positives = 125/367 (34%), Gaps = 86/367 (23%) Query: 163 DSMFFDRFLQWKWLERQ--------------PVTKNTFRQYRVLGKGGFGEVCACQVRAT 208 ++++F K R + + LG+G FG+V C A Sbjct: 16 ENLYFQSMQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHAR 75 Query: 209 GK-MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF---VVNLAYAYETKDALCLVLT 264 GK A K + + K R+ + +N + +++ + + V ++ + +C+ Sbjct: 76 GKSQVALKII-RNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFE 134 Query: 265 IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD--- 321 ++ G + + + A ++ L LH + DLKPENIL + Sbjct: 135 LL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEF 193 Query: 322 ----------------YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLS 365 IR++D G A + + V T Y PEV+ + Sbjct: 194 ETLYNEHKSCEEKSVKNTSIRVADFGSATF--DHEHHTTIVATRHYRPPEVILELGWAQP 251 Query: 366 PDYWGLGCLIYEMIEGQSPFRGRKEK---VKREEVDRRVL--------ETEEVY-----S 409 D W +GC+++E G + F+ + + V E++ + + + Y Sbjct: 252 CDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVW 311 Query: 410 HKFSEEAK------------------------SICKMLLTKDAKQRLGCQEEGAAEVKRH 445 + S + + + + +L D QR+ AE H Sbjct: 312 DENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITL-----AEALLH 366 Query: 446 PFFRNMN 452 PFF + Sbjct: 367 PFFAGLT 373 >2PMN-X nrPDB Length = 348 Score = 192 bits (488), Expect = 4e-49, Method: Composition-based stats. Identities = 65/333 (19%), Positives = 128/333 (38%), Gaps = 47/333 (14%) Query: 164 SMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIK 223 S + + K+++ + N +R R L +G F ++ C+ K YA K+ EK ++ Sbjct: 11 SNYSNLIYLNKYVKEKDKYINDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLE 68 Query: 224 KRKGE--------------SMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGG 269 K++ NE QI+ + +++ + D + ++ M Sbjct: 69 KKRDFTKSNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMEND 128 Query: 270 DL------KFHIYNMGNPGFEEERALFYAAEILCGLEDLH-RENTVYRDLKPENILLDDY 322 + F + + +L +H +N +RD+KP NIL+D Sbjct: 129 SILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKN 188 Query: 323 GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY--GLSPDYWGLGCLIYEMIE 380 G +++SD G + + + I+G GT +M PE +N+ G D W LG +Y M Sbjct: 189 GRVKLSDFGESEYMVD-KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFY 247 Query: 381 GQSPFR------GRKEKVKREEVDRRVLETEEVYS----------HKFSEEAKSICKMLL 424 PF ++ + ++ + +Y + S E K+ L Sbjct: 248 NVVPFSLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFL 307 Query: 425 TKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLE 457 K+ +R+ + + +H + + N + L Sbjct: 308 RKNPAERIT-----SEDALKHEWLADTNIEDLR 335 >3LMG-A nrPDB Length = 344 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 51/260 (19%), Positives = 97/260 (37%), Gaps = 15/260 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGK----MYACKRLEKKRIKKRKGESMALNEKQILEK 240 R+ +VLG G FG V G+ K +E K R+ + + Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDK--SGRQSFQAVTDHMLAIGS 89 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 ++ +V L +L LV + G L H+ + L + +I G+ Sbjct: 90 LDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQH-RGALGPQLLLNWGVQIAKGMY 147 Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---LIRGRVGTVGYMAPEVL 357 L V+R+L N+LL ++++D G+A +P D L + +MA E + Sbjct: 148 YLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESI 207 Query: 358 NNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 + +Y D W G ++E++ G P+ G + + +++ + + + Sbjct: 208 HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQ---PQICTIDV 264 Query: 417 KSICKMLLTKDAKQRLGCQE 436 + D R +E Sbjct: 265 YMVMVKCWMIDENIRPTFKE 284 >5WNL-A nrPDB Length = 342 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 104/281 (37%), Gaps = 18/281 (6%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231 +W + F + +G GGFG+V + A K + R+ Sbjct: 8 RWALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERME-L 66 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 L E + +E ++++ + + + LV+ M G L+ + + + Sbjct: 67 LEEAKKMEMAKFRYILPVYGICQE--PVGLVMEYMETGSLEKLL---ASEPLPWDLRFRI 121 Query: 292 AAEILCGLEDLH--RENTVYRDLKPENILLDDYGHIRISDLGLAV----KIPEGDLIRGR 345 E G+ LH ++ +LKP NILLD + H++ISD GLA + G Sbjct: 122 VHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGL 181 Query: 346 VGTVGYMAPEVLNNQR--YGLSPDYWGLGCLIYEMIEGQSPFRGRKE----KVKREEVDR 399 GT+ Y+ PE + + + D + +I+ ++ + PF K +K + R Sbjct: 182 FGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHR 241 Query: 400 RVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAA 440 L + + + D + R QE + Sbjct: 242 PELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEITSE 282 >3QD2-B nrPDB Length = 332 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 61/338 (18%), Positives = 119/338 (35%), Gaps = 83/338 (24%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 F + +G+GGFG V + + YA KR+ + + E + L K+ Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPN--RELAREKVMREVKALAKLEHP 64 Query: 245 FV---------------------------------------------VNLAYAYETKD-- 257 + + + TK+ Sbjct: 65 GIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTV 124 Query: 258 ----------ALCLVLTIMNGGDLKFHIYNMGNPGFEEE-RALFYAAEILCGLEDLHREN 306 L + + + +LK + + E L +I +E LH + Sbjct: 125 GQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKG 184 Query: 307 TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-------------LIRGRVGTVGYMA 353 ++RDLKP NI +++ D GL + + + G+VGT YM+ Sbjct: 185 LMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 PE ++ Y D + LG +++E++ F + E+V+ D R L+ +++ K+ Sbjct: 245 PEQIHGNNYSHKVDIFSLGLILFELLYS---FSTQMERVRI-ITDVRNLKFPLLFTQKYP 300 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 +E + +L+ +R A ++ + F N+ Sbjct: 301 QEHMM-VQDMLSPSPTER-----PEATDIIENAIFENL 332 >4IAN-A nrPDB Length = 358 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 119/336 (35%), Gaps = 76/336 (22%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRAT-GKMYACKRLEKKRIKKRKGESMALNEKQIL 238 V + Y G+G F V + A + A K + + + L E + L Sbjct: 26 EVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNEL----MQKTGLKELEFL 81 Query: 239 EKVNSQ------FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP-GFEEERALFY 291 +K+N + L + K LCLV ++ +L+ + G G + Y Sbjct: 82 KKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSY 140 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHI-RISDLGLAVKIPEGDLIRGRVGTVG 350 + ++ L+ L R N ++ D+KP+NIL+++ I ++ D G A + + D+ V + Sbjct: 141 SQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLV-SRF 199 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE--------------- 395 Y APE++ + Y D W +GC +YE+ G+ F G+ + Sbjct: 200 YRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIR 259 Query: 396 ------EVDRRVLETEEVYSHKFSE----------------------------------- 414 + + L + K +E Sbjct: 260 KGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVH 319 Query: 415 EAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 + K + +L D +R+ + +H F + Sbjct: 320 QLKDLLDQILMLDPAKRISIN-----QALQHAFIQE 350 >4LQP-A nrPDB Length = 508 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 57/169 (33%), Positives = 93/169 (55%), Gaps = 2/169 (1%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231 Q+ L R ++ F +V+GKG FGEV Q + TGK+YA K L K + K+ + Sbjct: 90 QFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHV 149 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 E+ +L +S +VV+L Y+++ L L++ + GGDL + F E+ FY Sbjct: 150 KAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRW--QLFTEDVTRFY 207 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD 340 AE + +E +H+ ++R +KP+NIL+D GHI++SD GL+ + Sbjct: 208 MAECILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTH 256 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 45/150 (30%), Positives = 75/150 (50%), Gaps = 12/150 (8%) Query: 341 LIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400 + VGT Y+APE+ Q YG D+W LG ++YE + G PF +E R+ Sbjct: 319 MAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETP----QETYRK 374 Query: 401 VLETEEV--YSH--KFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRL 456 ++ E+ + S EA+ + + LLT A QRLG + GA E+K HPFFR +++ + Sbjct: 375 IMNFEQTLQFPDDIHISYEAEDLIRRLLTH-ADQRLG-RHGGADEIKSHPFFRGVDWNTI 432 Query: 457 EAGMLDPPFVPDPRAVYCKDVLDIEQFSTV 486 ++ P++P ++ ++ V Sbjct: 433 --RQVEAPYIPKLSSITDTRFFPTDELENV 460 >6HV0-A nrPDB Length = 416 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 119/306 (38%), Gaps = 40/306 (13%) Query: 185 TFRQYRVLGKGGFGE-VCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 +F VLG G G V + A KR+ + E L E Sbjct: 9 SFCPKDVLGHGAEGTIVYRGMF--DNRDVAVKRILPECFSFADREVQLLRESD-----EH 61 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 V+ + + + + + L+ ++ E + GL LH Sbjct: 62 PNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLH 119 Query: 304 RENTVYRDLKPENILL---DDYGHIR--ISDLGLAVKI----PEGDLIRGRVGTVGYMAP 354 N V+RDLKP NIL+ + +G I+ ISD GL K+ G GT G++AP Sbjct: 120 SLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAP 179 Query: 355 EVLNN---QRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 E+L+ + + D + GC+ Y +I G PF K ++ + + ++ Sbjct: 180 EMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF--GKSLQRQANILLGACSLDCLHPE 237 Query: 411 KFSEE-AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF----RNMNF-----KRLEAGM 460 K + A+ + + ++ D ++R A V +HPFF + + F R+E Sbjct: 238 KHEDVIARELIEKMIAMDPQKR-----PSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKES 292 Query: 461 LDPPFV 466 LD P V Sbjct: 293 LDGPIV 298 >5XD6-A nrPDB Length = 305 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 51/221 (23%), Positives = 94/221 (42%), Gaps = 19/221 (8%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 E + +T + + ++G+G +G V ++ +GK A K+L+ ++ + L + Sbjct: 16 ELRDIT-DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLD----SSKQPDQEFLAQVS 69 Query: 237 ILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN-------PGFEEERAL 289 ++ ++ + VV L L G L ++ P + + Sbjct: 70 MVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRV 129 Query: 290 FYAAEILCGLEDLHRE---NTVYRDLKPENILLDDYGHIRISDLGLAVKIPE--GDLIRG 344 A GLE LH + + ++RD+K N+LL D +I+D L+ + P+ L Sbjct: 130 KIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHST 189 Query: 345 RV-GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSP 384 RV GT GY APE D + G ++ E++ G+ P Sbjct: 190 RVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >4PL5-B nrPDB Length = 435 Score = 189 bits (479), Expect = 5e-48, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 118/306 (38%), Gaps = 40/306 (13%) Query: 185 TFRQYRVLGKGGFGE-VCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 +F VLG G G V + A KR+ + E L E Sbjct: 28 SFCPKDVLGHGAEGTIVYKGMF--DNRDVAVKRILPECFSFADREVQLLRESD-----EH 80 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 V+ + + + + + L+ ++ E + GL LH Sbjct: 81 PNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLH 138 Query: 304 RENTVYRDLKPENILL---DDYGHIR--ISDLGLAVKI----PEGDLIRGRVGTVGYMAP 354 N V+RDLKP NILL + +G I+ ISD GL K+ G GT G++AP Sbjct: 139 SLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAP 198 Query: 355 EVLNN---QRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 E+L+ + D + GC+ Y +I G PF K ++ + + +S Sbjct: 199 EMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF--GKSLQRQANILLGACNLDCFHSD 256 Query: 411 KFSEE-AKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF----RNMNF-----KRLEAGM 460 K + A+ + + ++ D +QR A V +HPFF + + F R+E Sbjct: 257 KHEDVIARELIEKMIAMDPQQR-----PSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEA 311 Query: 461 LDPPFV 466 LD P V Sbjct: 312 LDGPIV 317 >2BUJ-A nrPDB Length = 317 Score = 188 bits (477), Expect = 8e-48, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 110/290 (37%), Gaps = 32/290 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + + + LG+GGF V + G YA KR+ +++ A E + Sbjct: 26 IDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI---LCHEQQDREEAQREADMHRL 82 Query: 241 VNSQFVVNLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPG--FEEERALFYAAE 294 N ++ L K L+L G L I + + G E++ L+ Sbjct: 83 FNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLG 142 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGL----------AVKIPEGDLIRG 344 I GLE +H + +RDLKP NILL D G + DLG + + Sbjct: 143 ICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAA 202 Query: 345 RVGTVGYMAPEVLNNQRY---GLSPDYWGLGCLIYEMIEGQSP----FRGRKEKVKREEV 397 + T+ Y APE+ + Q + D W LGC++Y M+ G+ P F+ + Sbjct: 203 QRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQN 262 Query: 398 DRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAA-EVKRHP 446 + ++ S + + ++T D QR + E + P Sbjct: 263 QLSIPQSPRHSSALW-----QLLNSMMTVDPHQRPHIPLLLSQLEALQPP 307 >2H34-A nrPDB Length = 309 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 55/248 (22%), Positives = 103/248 (41%), Gaps = 5/248 (2%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 +R R++G+GG G+V + ++ A K + + + E + ++ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRE 305 VV + E L + + ++NG DL + G RA+ +I L+ H Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGP--LAPPRAVAIVRQIGSALDAAHAA 153 Query: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR--GRVGTVGYMAPEVLNNQRYG 363 +RD+KPENIL+ + D G+A + L + VGT+ YMAPE + Sbjct: 154 GATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHAT 213 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 D + L C++YE + G P++G + V +++ + ++ Sbjct: 214 YRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPR-PSTVRPGIPVAFDAVIARG 272 Query: 424 LTKDAKQR 431 + K+ + R Sbjct: 273 MAKNPEDR 280 >5TE0-A nrPDB Length = 347 Score = 187 bits (474), Expect = 2e-47, Method: Composition-based stats. Identities = 63/283 (22%), Positives = 108/283 (38%), Gaps = 37/283 (13%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI 237 RQ VT + VL +GGF V + + G A KR+ + + E QI Sbjct: 18 RQQVTVD-----EVLAEGGFAIVFLVR-TSNGMKCALKRM---FVNNEHDLQVCKREIQI 68 Query: 238 LEKV-NSQFVVNLAYA----YETKD--ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF 290 + + + +V + + D + +++ GG + + GF E L Sbjct: 69 MRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQ 128 Query: 291 YAAEILCGLEDLHREN--TVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG---- 344 + + LH+ ++RDLK ENILL D GH + D G A + G Sbjct: 129 IFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAV 188 Query: 345 -----RVGTVGYMAPEVLN---NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE 396 + T+ Y APE++N + D W LGCL+Y++ PF + Sbjct: 189 EDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFG-------ESQ 241 Query: 397 VDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGA 439 V + ++S++ + + +L D +R + Sbjct: 242 VAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSY 284 >5AR8-A nrPDB Length = 326 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 103/291 (35%), Gaps = 20/291 (6%) Query: 163 DSMFFDRFLQWKWLERQP-VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKR 221 ++++F P + + R L +G G V + + A K L Sbjct: 10 ENLYFQGMNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHT 69 Query: 222 IKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN- 280 L E +IL K +++ + + L +V M G L ++ Sbjct: 70 PLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEY 129 Query: 281 PGFEEERALFYAAEILCGLEDLHRE--NTVYRDLKPENILLDDYGHIRISDLGLAV---- 334 P EI G+ LH ++ DLK +NILLD+ H++I+D GL+ Sbjct: 130 PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMM 189 Query: 335 --KIPEGDLIRGRVGTVGYMAPEVL---NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRK 389 GT+ YM PE R + D + + +E++ + PF Sbjct: 190 SLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVT 249 Query: 390 EKVKR----EEVDRRVLETEEVYSHKFSEEAK--SICKMLLTKDAKQRLGC 434 ++ + R V+ EE + A+ S+ + ++ +R Sbjct: 250 NPLQIMYSVSQGHRPVIN-EESLPYDIPHRARMISLIESGWAQNPDERPSF 299 >6BFN-A nrPDB Length = 342 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 95/239 (39%), Gaps = 18/239 (7%) Query: 173 WKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKK-RIKKRKGESMA 231 W E T N F + +G+GGFG V +R T +YA KRL++ ++ + Sbjct: 12 WPLCEISRGTHN-FSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSF 68 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIY--NMGNPGFEEERAL 289 L E + L + +V+ A CLV + G L+ ++ P + L Sbjct: 69 LTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL 128 Query: 290 FYAAEILCGLEDLH--RENTVYRDLKPENILLDDYGHIRISDLGLAV----------KIP 337 ++ LH + ++ D+K N+LLD+ ++ D GLA + Sbjct: 129 DILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSS 188 Query: 338 EGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREE 396 + GT+ Y+ E + R + D + G ++ E + GQ + + K + Sbjct: 189 MVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLK 247 >5VC6-A nrPDB Length = 289 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 100/284 (35%), Gaps = 38/284 (13%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-NS 243 F + +G G FG V C R G +YA KR KK + E AL E + Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR-SKKPLAGSVDEQNALREVYAHAVLGQH 70 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN--PGFEEERALFYAAEILCGLED 301 VV A+ D + + NGG L I F+E ++ GL Sbjct: 71 SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 302 LHRENTVYRDLKPENILLDDYGH-------------------IRISDLGLAVKIPEGDLI 342 +H + V+ D+KP NI + +I DLG +I + Sbjct: 131 IHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQV- 189 Query: 343 RGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV 401 G ++A EVL N + D + L + G P R E R+ Sbjct: 190 --EEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP-RNGDQWHEIRQGRL 245 Query: 402 LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRH 445 +V S+E + K+++ D ++R A + +H Sbjct: 246 PRIPQV----LSQEFTELLKVMIHPDPERR-----PSAMALVKH 280 >3Q4U-A nrPDB Length = 301 Score = 182 bits (463), Expect = 3e-46, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 100/300 (33%), Gaps = 52/300 (17%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 Q +GKG +GEV + G+ A K + K E+ N Sbjct: 3 QRTVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTV--- 57 Query: 239 EKVNSQFVVNLAYAYETKDA----LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 + + ++ + T L L+ G L ++ + L Sbjct: 58 -MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLT---TLDTVSCLRIVLS 113 Query: 295 ILCGLEDLH--------RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL----- 341 I GL LH + +RDLK +NIL+ G I+DLGLAV + Sbjct: 114 IASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVG 173 Query: 342 IRGRVGTVGYMAPEVLNNQ-------RYGLSPDYWGLGCLIYEMIEG----------QSP 384 RVGT YMAPEVL+ Y D W G +++E+ + P Sbjct: 174 NNPRVGTKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPP 232 Query: 385 FRGRKEKVKREEVDRRVLETEEVYS----HKFSE----EAKSICKMLLTKDAKQRLGCQE 436 F E R+V+ ++ FS+ + K ++ RL Sbjct: 233 FYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALR 292 >4CRL-A nrPDB Length = 406 Score = 182 bits (461), Expect = 5e-46, Method: Composition-based stats. Identities = 68/348 (19%), Positives = 122/348 (35%), Gaps = 75/348 (21%) Query: 165 MFFDRFLQWKWLERQPVTKNTFRQYR-VLGKGGFGEVCACQVRATGKM--YACKRLEKKR 221 D + K + ++ F +G+G +G V + + YA K++E Sbjct: 2 DKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTG 61 Query: 222 IKKRKGESMALNEKQILEKVNSQFVVNLAYAYET--KDALCLVLTIMNGGDLKFHIY--- 276 I A E +L ++ V++L + + + L+ DL I Sbjct: 62 ISMS-----ACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHR 115 Query: 277 ----NMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLD----DYGHIRIS 328 N +IL G+ LH ++RDLKP NIL+ + G ++I+ Sbjct: 116 ASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIA 175 Query: 329 DLGLAVKIPEG----DLIRGRVGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIEGQS 383 D+G A + V T Y APE+L + Y + D W +GC+ E++ + Sbjct: 176 DMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEP 235 Query: 384 PFRGRKEKVKREEVDR-----RVLET---------------------------------- 404 F R+E +K R+ Sbjct: 236 IFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCS 295 Query: 405 --EEVYSHKFSEEAK--SICKMLLTKDAKQRLGCQEEGAAEVKRHPFF 448 + + HK ++K + + LLT D +R+ + + + P+F Sbjct: 296 LIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRIT-----SEQAMQDPYF 338 >5IKW-A nrPDB Length = 310 Score = 181 bits (459), Expect = 8e-46, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 102/274 (37%), Gaps = 31/274 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V ++ L +GGF V + G A KR+ + + E I+++ Sbjct: 11 VGRHQVTLEESLAEGGFSTVFLVRTHG-GIRCALKRMYVNNMPDLN---VCKREITIMKE 66 Query: 241 V-NSQFVVNLAYAYETK--DALC---LVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 + + +V D + +++ G + + GF E L + Sbjct: 67 LSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCD 126 Query: 295 ILCGLEDLHREN--TVYRDLKPENILLDDYGHIRISDLGLAV---KIPEGDLIRG----- 344 + LH+ ++RDLK ENILL+D G+ + D G A P+ D + Sbjct: 127 TCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEI 186 Query: 345 -RVGTVGYMAPEVLN---NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400 + T+ Y APE++N + D W LGCL+Y++ PF +V Sbjct: 187 KKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFG-------ESQVAIC 239 Query: 401 VLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGC 434 + ++S + + +L D + R Sbjct: 240 DGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDI 273 >2JD5-A nrPDB Length = 373 Score = 181 bits (459), Expect = 8e-46, Method: Composition-based stats. Identities = 64/332 (19%), Positives = 117/332 (35%), Gaps = 78/332 (23%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 + R LG G F V + A K + ++ E E ++L++VN Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAED----EIKLLQRVNDA 75 Query: 245 -----------FVVNLAYAYETKD----ALCLVLTIMNGGDLKFHIYNMGNPGFEEERAL 289 ++ L + K + +V ++ G +L I + G Sbjct: 76 DNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVL-GENLLALIKKYEHRGIPLIYVK 134 Query: 290 FYAAEILCGLEDLHRE-NTVYRDLKPENILLD------DYGHIRISDLGLAVKIPEGDLI 342 + ++L GL+ +HR ++ D+KPEN+L++ + I+I+DLG A E Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEH--Y 192 Query: 343 RGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPF-------RGRKEKVKRE 395 + T Y +PEVL +G D W CLI+E+I G F + + + Sbjct: 193 TNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQ 252 Query: 396 EVD-------------------------------------RRVLETEEVYSHKFSEEAKS 418 ++ VL + +S ++E Sbjct: 253 IIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISD 312 Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRN 450 +L D ++R A + HP+ ++ Sbjct: 313 FLSPMLQLDPRKR-----ADAGGLVNHPWLKD 339 >5VDK-A nrPDB Length = 297 Score = 179 bits (454), Expect = 4e-45, Method: Composition-based stats. Identities = 72/291 (24%), Positives = 110/291 (37%), Gaps = 41/291 (14%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV- 241 + F + +G G FG V C R G +YA KR K + E+ AL+E + Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHAVLG 72 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPG--FEEERALFYAAEILCGL 299 + VV ++ D + + NGG L+ I G FEE + +I GL Sbjct: 73 HHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGL 132 Query: 300 EDLHRENTVYRDLKPENILL------DDYGHI-----------------RISDLGLAVKI 336 +H + V+ D+KP NI + + G I +I DLG A I Sbjct: 133 NYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI 192 Query: 337 PEGDLIRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEG--QSPFRGRKEKVK 393 + + G ++A E+L + R+ D + LG I + G P G Sbjct: 193 ---NKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGAESLPTNGAAWHHI 248 Query: 394 REEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKR 444 R+ V + SE S+ K ++ DA+QR V R Sbjct: 249 RKGNFPDV-------PQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLR 292 >3SV0-A nrPDB Length = 483 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 103/256 (40%), Gaps = 26/256 (10%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 +P N FR R +G G FGE+ T + A K K + L E +I Sbjct: 2 EPRVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQ-----LLYESKIY 56 Query: 239 EKVNSQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + + N+ + D LV+ ++ G L+ ++N + + L A +++ Sbjct: 57 RILQGGTGIPNVRWFGVEGDYNVLVMDLL-GPSLED-LFNFCSRKLSLKTVLMLADQMIN 114 Query: 298 GLEDLHRENTVYRDLKPENILLD---DYGHIRISDLGLAVKIPEGDLI--------RGRV 346 +E +H ++ ++RD+KP+N L+ + I D GLA K + + Sbjct: 115 RVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLT 174 Query: 347 GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEE 406 GT Y + D LG ++ + G P++G K K+++ E+ Sbjct: 175 GTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKY-------EK 227 Query: 407 VYSHKFSEEAKSICKM 422 + K + +++C+ Sbjct: 228 ISEKKVATSIEALCRG 243 >2Y4I-B nrPDB Length = 319 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 106/275 (38%), Gaps = 23/275 (8%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNE 234 +L+ + ++GKG FG+V + A + ++ +R E Sbjct: 24 FLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIER-DNEDQLKAFKRE 79 Query: 235 KQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 + + VV A + L ++ ++ G L + + + + A E Sbjct: 80 VMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRD-AKIVLDVNKTRQIAQE 138 Query: 295 ILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGL---AVKIPEG---DLIRGRVGT 348 I+ G+ LH + +++DLK +N+ D G + I+D GL + + G D +R + G Sbjct: 139 IVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGW 197 Query: 349 VGYMAPEVLNN---------QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 + ++APE++ + D + LG + YE+ + PF+ + + ++ Sbjct: 198 LCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGT 257 Query: 400 RVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGC 434 + + +E I + ++R Sbjct: 258 GMK--PNLSQIGMGKEISDILLFCWAFEQEERPTF 290 >3MDY-A nrPDB Length = 337 Score = 174 bits (442), Expect = 7e-44, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 106/302 (35%), Gaps = 56/302 (18%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 Q + + +GKG +GEV + R G+ A K E+ E +I Sbjct: 32 QRTIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFF------TTEEASWFRETEIY 83 Query: 239 EKV--NSQFVVNLAYAYETKD----ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 + V + ++ A L L+ G L ++ + + + L A Sbjct: 84 QTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKST---TLDAKSMLKLA 140 Query: 293 AEILCGLEDLH--------RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD---- 340 + GL LH + +RDLK +NIL+ G I+DLGLAVK Sbjct: 141 YSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVD 200 Query: 341 -LIRGRVGTVGYMAPEVLNN-------QRYGLSPDYWGLGCLIYEMIEG----------Q 382 RVGT YM PEVL+ Q Y + D + G +++E+ Q Sbjct: 201 IPPNTRVGTKRYMPPEVLDESLNRNHFQSY-IMADMYSFGLILWEVARRCVSGGIVEEYQ 259 Query: 383 SPFRGRKEKVKREEVDRRVLETE---EVYSHKFSEEAK-----SICKMLLTKDAKQRLGC 434 P+ E R ++ + + +++S + + + RL Sbjct: 260 LPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA 319 Query: 435 QE 436 Sbjct: 320 LR 321 >4M66-A nrPDB Length = 325 Score = 174 bits (442), Expect = 9e-44, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 102/278 (36%), Gaps = 33/278 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V++ ++ +GKGGFG V R A K + K+I E + + Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW---------EVKAMVN 67 Query: 241 VNSQFVVNLAYAYETKDALC-----LVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 + ++ V+ L E LV M G L + E+ Sbjct: 68 LRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR--PWPLLCRLLQEV 125 Query: 296 LCGLEDLHR--ENTVYRDLKPENILLDDYGHIRISDLGLAV-------KIPEGDLIRGRV 346 + G+ LH ++RDLKP NILLD H +++D GL+ G R Sbjct: 126 VLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSG 185 Query: 347 GTVGYMAPEVLN--NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 GT+ Y+ PE+L N + + D + G L++ ++ G+ K + RE V R Sbjct: 186 GTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRP 245 Query: 405 EEVYSHKFSEE------AKSICKMLLTKDAKQRLGCQE 436 S E K + ++ R Q+ Sbjct: 246 PLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQD 283 >3MY0-A nrPDB Length = 305 Score = 174 bits (442), Expect = 9e-44, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 94/291 (32%), Gaps = 52/291 (17%) Query: 188 QYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 +GKG +GEV G+ A K + + E+ N + ++ Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRETEIYNTV----LLRHDNIL 65 Query: 248 NLAYAYETK----DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + T L L+ G L + E AL A CGL LH Sbjct: 66 GFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ---RQTLEPHLALRLAVSAACGLAHLH 122 Query: 304 --------RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI-----RGRVGTVG 350 + +RD K N+L+ I+DLGLAV +G RVGT Sbjct: 123 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR 182 Query: 351 YMAPEVLNNQRYG------LSPDYWGLGCLIYEMIEG----------QSPFRGRKEKVKR 394 YMAPEVL+ Q D W G +++E+ + PF Sbjct: 183 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPS 242 Query: 395 EEVDRRVLETEEVYS---------HKFSEEAKSICKMLLTKDAKQRLGCQE 436 E ++V+ ++ S A+ + + RL Sbjct: 243 FEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQM-MRECWYPNPSARLTALR 292 >4TN6-A nrPDB Length = 318 Score = 174 bits (441), Expect = 1e-43, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 103/253 (40%), Gaps = 26/253 (10%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 N +R R +G G FG++ A G+ A K LE + K + E +I + + Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHI----ESKIYKMM 59 Query: 242 NS-QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + + + D +V+ ++ G L+ ++N + F + L A +++ +E Sbjct: 60 QGGVGIPTIRWCGAEGDYNVMVMELL-GPSLED-LFNFCSRKFSLKTVLLLADQMISRIE 117 Query: 301 DLHRENTVYRDLKPENILL---DDYGHIRISDLGLAVKIPEGDLI--------RGRVGTV 349 +H +N ++RD+KP+N L+ + I D GLA K + + GT Sbjct: 118 YIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTA 177 Query: 350 GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS 409 Y + D LG ++ G P++G K KR++ +R + Sbjct: 178 RYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYER-------ISE 230 Query: 410 HKFSEEAKSICKM 422 K S + +CK Sbjct: 231 KKMSTPIEVLCKG 243 >4LFI-A nrPDB Length = 374 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 62/371 (16%), Positives = 125/371 (33%), Gaps = 89/371 (23%) Query: 149 VHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRAT 208 V+ + + EY D + + + W + + +G+G + EV + Sbjct: 13 VYTNINKQRTEEYWD--YENTVIDWSTNTK------DYEIENKVGRGKYSEVFQGVKLDS 64 Query: 209 GKMYAC-----------------------KRLEKKRIKKRKGESMALNEKQILE------ 239 +++ + +K + ++ +L+ Sbjct: 65 KVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYI 124 Query: 240 ----KVNSQFVVNLAYAYETK--DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 +++L + LV ++ D + + P + FY Sbjct: 125 FDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD-----FRILYPKLTDLEIRFYMF 179 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDD-YGHIRISDLGLAVKIPEGDLIRGRVGTVGYM 352 E+L L+ H ++RD+KP N+++D +R+ D GLA RV + + Sbjct: 180 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFK 239 Query: 353 APEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSP-FRGRKEKVKREEV---------DRRV 401 PE+L + + Y S D W G ++ MI + P F G + ++ ++ + Sbjct: 240 GPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYL 299 Query: 402 LETEEVYSHKF------------------------SEEAKSICKMLLTKDAKQRLGCQEE 437 L+ E +F ++E + LL D ++RL Sbjct: 300 LKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLT---- 355 Query: 438 GAAEVKRHPFF 448 A E HP+F Sbjct: 356 -AKEAMGHPWF 365 >1PY5-A nrPDB Length = 326 Score = 172 bits (436), Expect = 4e-43, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 101/292 (34%), Gaps = 54/292 (18%) Query: 188 QYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE--KVNSQF 245 +GKG FGEV + R G+ A K + E E +I + + + Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIF------SSREERSWFREAEIYQTVMLRHEN 84 Query: 246 VVNLAYAYETKD----ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 ++ A + L LV G L ++ E + A GL Sbjct: 85 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL---NRYTVTVEGMIKLALSTASGLAH 141 Query: 302 LH--------RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI-----RGRVGT 348 LH + +RDLK +NIL+ G I+DLGLAV+ RVGT Sbjct: 142 LHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGT 201 Query: 349 VGYMAPEVLNNQ------RYGLSPDYWGLGCLIYEMIEG----------QSPFRGRKEKV 392 YMAPEVL++ D + +G + +E+ Q P+ Sbjct: 202 KRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSD 261 Query: 393 KREEVDRRVLETEEVYS----HKFSEEA----KSICKMLLTKDAKQRLGCQE 436 E R+V+ +++ S EA I + + RL Sbjct: 262 PSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALR 313 >4F9B-A nrPDB Length = 361 Score = 171 bits (433), Expect = 9e-43, Method: Composition-based stats. Identities = 65/366 (17%), Positives = 113/366 (30%), Gaps = 105/366 (28%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQV---RATGKMYACKRLEKKRIKKRKGESM 230 K E P N F+ +G+G F V + A K L Sbjct: 11 KLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL-----IPTSHPIR 65 Query: 231 ALNEKQILEKVNSQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERAL 289 E Q L Q V+ + Y + D + + + + + + + Sbjct: 66 IAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS-----LSFQEVR 120 Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIR---ISDLGLAVKIPEG------- 339 Y + L+ +H+ V+RD+KP N L + ++ + D GLA + Sbjct: 121 EYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRR--LKKYALVDFGLAQGTHDTKIELLKF 178 Query: 340 ----------------------DLIRGRVGTVGYMAPEVLNNQR-YGLSPDYWGLGCLIY 376 + R GT G+ APEVL + D W G + Sbjct: 179 VQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFL 238 Query: 377 EMIEGQSPFR----------------GRKEKVKREEVDRR-VLETEEVY----------- 408 ++ G+ PF G +E ++ + + +L ++EV Sbjct: 239 SLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERL 298 Query: 409 -----------------------SHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRH 445 ++ +EA + LL + R+ A E H Sbjct: 299 RGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRIT-----AEEALLH 353 Query: 446 PFFRNM 451 PFF++M Sbjct: 354 PFFKDM 359 >5FQD-C nrPDB Length = 341 Score = 170 bits (432), Expect = 1e-42, Method: Composition-based stats. Identities = 52/259 (20%), Positives = 102/259 (39%), Gaps = 23/259 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 + ++ R +G G FG++ G+ A K ++ L E ++ + Sbjct: 16 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-----LESQKARHPQLLYESKLYKI 70 Query: 241 VNS-QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + + ++ + + KD LV+ ++ G L+ ++N + F + L A +++ + Sbjct: 71 LQGGVGIPHIRWYGQEKDYNVLVMDLL-GPSLED-LFNFCSRRFTMKTVLMLADQMISRI 128 Query: 300 EDLHRENTVYRDLKPENILLDDYGHI-R--ISDLGLAVKIPEGDL--------IRGRVGT 348 E +H +N ++RD+KP+N L+ H + + D GLA K + + GT Sbjct: 129 EYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGT 188 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE---KVKREEVDRRVLETE 405 Y + D LG ++ P++G K K K E++ + + T Sbjct: 189 ARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTP 248 Query: 406 -EVYSHKFSEEAKSICKML 423 EV F E Sbjct: 249 VEVLCKGFPAEFAMYLNYC 267 >5CEK-A nrPDB Length = 263 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 97/257 (37%), Gaps = 25/257 (9%) Query: 200 VCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDAL 259 V TG+ CK K + + + L + + + + Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQL--------PSHSNITGIVEVILGETKA 76 Query: 260 CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL 319 + + GD+ ++ + EE A +I+ + H+ V DLK + Sbjct: 77 YVFFE-KDFGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 133 Query: 320 D--DYGHIRISDL-GLAVKIPEGDLIRGRVGTVGYMAPEVLN--NQRYGLSPDYWGLGCL 374 + +R+ L + E D + + G Y++PE+LN G + D W LG + Sbjct: 134 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 193 Query: 375 IYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGC 434 +Y ++ G+ PF ++ R E S +A+ + + LL ++ +RL Sbjct: 194 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE----HISPKARCLIRSLLRREPSERLT- 248 Query: 435 QEEGAAEVKRHPFFRNM 451 A E+ HP+F ++ Sbjct: 249 ----APEILLHPWFESV 261 >6DC0-A nrPDB Length = 292 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 97/257 (37%), Gaps = 25/257 (9%) Query: 200 VCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDAL 259 V TG+ CK K + + + L + + + + Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQL--------PSHSNITGIVEVILGETKA 73 Query: 260 CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL 319 + + GD+ ++ + EE A +I+ + H+ V DLK + Sbjct: 74 YVFFE-KDFGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 130 Query: 320 D--DYGHIRISDL-GLAVKIPEGDLIRGRVGTVGYMAPEVLN--NQRYGLSPDYWGLGCL 374 + +R+ L + E D + + G Y++PE+LN G + D W LG + Sbjct: 131 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 190 Query: 375 IYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGC 434 +Y ++ G+ PF ++ R E S +A+ + + LL ++ +RL Sbjct: 191 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE----HISPKARCLIRSLLRREPSERLT- 245 Query: 435 QEEGAAEVKRHPFFRNM 451 A E+ HP+F ++ Sbjct: 246 ----APEILLHPWFESV 258 >5L2Q-C nrPDB Length = 320 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 69/284 (24%), Positives = 119/284 (41%), Gaps = 49/284 (17%) Query: 201 CACQVRATGKMYACKRLEKKRIKKRKGESMALN--------EKQILEKVNSQ-FVVNLAY 251 C + T Y K L + + ES E +L +++Q VV+ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 252 AYET------------------KDALCLVLTIMNGGDLKF---HIYNMGN-----PGFEE 285 ++ K +CLVL + D + N+ + E Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH-IRISDLGLAVKI-PEGDLIR 343 + +++ +E LH++N V+RDLK N++L+ H I I++ L + EGDL++ Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 344 GRVGTVGYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVL 402 + G+ Y++P+VL+ + Y G D W LG +++ M+ GQ PF +E+ R++ Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDS----IPQELFRKIK 268 Query: 403 ETEEVYSHK--FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKR 444 E SE + + LL D +QRL AA+V Sbjct: 269 AAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLA-----AADVLE 307 >2WTK-B nrPDB Length = 373 Score = 167 bits (422), Expect = 2e-41, Method: Composition-based stats. Identities = 65/369 (17%), Positives = 112/369 (30%), Gaps = 67/369 (18%) Query: 186 FRQYRVLGKGGFG---EVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 + V+GKG F V + + TG+ +R+ + + E + + N Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNE-MVTFLQGELHVSKLFN 68 Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 +V + + L +V + M G K I G E + +L L+ + Sbjct: 69 HPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYI 128 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE----------GDLIRGRVGTVGYM 352 H V+R +K +IL+ G + +S GL + D + V + ++ Sbjct: 129 HHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWL 186 Query: 353 APEVLNN--QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE------- 403 +PEVL Q Y D + +G E+ G PF+ E + Sbjct: 187 SPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTST 246 Query: 404 -----------------------------------TEEVYSHKFSEEAKSICKMLLTKDA 428 Y FS + L ++ Sbjct: 247 IPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNP 306 Query: 429 KQRLGCQEEGAAEVKRHPFFRNMNFKRLEA-GMLDPPFVPDPRAVYCKDVLDIEQFSTVK 487 R A+ + H FF+ + + EA L P P + F V Sbjct: 307 DAR-----PSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVT 361 Query: 488 GVNLDHTDD 496 + DD Sbjct: 362 NLEELEVDD 370 >4WUA-A nrPDB Length = 401 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 68/372 (18%), Positives = 113/372 (30%), Gaps = 118/372 (31%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS- 243 + R LG G F V K A K ++ AL+E ++L+ V + Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK----SAEHYTETALDEIRLLKSVRNS 97 Query: 244 -QF------VVNLAYAYE----TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 VV L ++ +C+V ++ G L I G Sbjct: 98 DPNDPNREMVVQLLDDFKISGVNGTHICMVFEVL-GHHLLKWIIKSNYQGLPLPCVKKII 156 Query: 293 AEILCGLEDLHRE-NTVYRDLKPENILLD------------------------------- 320 ++L GL+ LH + ++ D+KPENILL Sbjct: 157 QQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVST 216 Query: 321 ------------------DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 + ++I+DLG A + + + T Y + EVL Y Sbjct: 217 APATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKH--FTEDIQTRQYRSLEVLIGSGY 274 Query: 363 GLSPDYWGLGCLIYEMIEGQSPF---------RGRKEKVKREEVDRRVLE--------TE 405 D W C+ +E+ G F R E+ +V ++ Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSK 334 Query: 406 EVYSHK-----------------------FSEE----AKSICKMLLTKDAKQRLGCQEEG 438 E ++ K +S+E +L ++R Sbjct: 335 EFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKR-----AT 389 Query: 439 AAEVKRHPFFRN 450 AAE RHP+ + Sbjct: 390 AAECLRHPWLNS 401 >2X7G-A nrPDB Length = 389 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 65/370 (17%), Positives = 110/370 (29%), Gaps = 116/370 (31%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN-- 242 + R LG G F V C + A K ++ + AL+E ++L+ V Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK----SAQHYTETALDEIKLLKCVRES 87 Query: 243 ---SQF---VVNLAYAYETKD----ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 VV L ++ +C+V ++ G L I G Sbjct: 88 DPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL-GHHLLKWIIKSNYQGLPVRCVKSII 146 Query: 293 AEILCGLEDLHRE-NTVYRDLKPENILL-------------------------------- 319 ++L GL+ LH + ++ D+KPENIL+ Sbjct: 147 RQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVST 206 Query: 320 ---------------DDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL 364 D ++I+DLG A + + + T Y + EVL Y Sbjct: 207 APAADLLVNPLDPRNADKIRVKIADLGNACWVHKH--FTEDIQTRQYRSIEVLIGAGYST 264 Query: 365 SPDYWGLGCLIYEMIEGQSPF-------RGRKEKVKREEVD------------------- 398 D W C+ +E+ G F R E ++ Sbjct: 265 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF 324 Query: 399 ------------------RRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAA 440 VL + + H+ + + +L ++R A Sbjct: 325 FNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKR-----ASAG 379 Query: 441 EVKRHPFFRN 450 E RHP+ + Sbjct: 380 ECLRHPWLNS 389 >5E8V-A nrPDB Length = 316 Score = 165 bits (418), Expect = 5e-41, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 102/291 (35%), Gaps = 53/291 (18%) Query: 191 VLGKGGFGEVCACQVRATG----KMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFV 246 ++GKG F EV +++ + A K + K E ++ + + + Sbjct: 16 LVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN----LKHENI 71 Query: 247 VNLAYAYETKDAL----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 + A E K L L+ G+L+ ++ E + + G+ L Sbjct: 72 LQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH---VISWEDLRKLGSSLARGIAHL 128 Query: 303 HR---------ENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-----EGDLIRGRVGT 348 H V+RDLK NIL+ + + D GL++++ + G+VGT Sbjct: 129 HSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGT 188 Query: 349 VGYMAPEV------LNNQRYGLSPDYWGLGCLIYEMIEG----------QSPFRGR-KEK 391 YMAPEV L N D + + +++EM + PF + +E Sbjct: 189 ARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREH 248 Query: 392 VKREEVDRRVLET---EEVYSHKFS----EEAKSICKMLLTKDAKQRLGCQ 435 + VL E+ S + + D + RL Q Sbjct: 249 PCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQ 299 >2CMW-A nrPDB Length = 310 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 109/255 (42%), Gaps = 28/255 (10%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS--Q 244 R + +G G FGE+ + T + A K + IK R + E + +++ S + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL--EYRFYKQLGSAGE 57 Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 + + Y +VL ++ G L+ ++++ + F + L A ++L +E +H Sbjct: 58 GLPQVYYFGPCGKYNAMVLELL-GPSLED-LFDLCDRTFTLKTVLMIAIQLLSRMEYVHS 115 Query: 305 ENTVYRDLKPENILLDDYGH-----IRISDLGLAVKIPEGDL--------IRGRVGTVGY 351 +N +YRD+KPEN L+ G+ I I D GLA + + + + GT Y Sbjct: 116 KNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 175 Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE-----E 406 M+ + D LG + + G P++G K +E +++ +T+ E Sbjct: 176 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERY-QKIGDTKRNTPIE 234 Query: 407 VYSHKFSEEAKSICK 421 F EE + + Sbjct: 235 ALCENFPEEMATYLR 249 >4BTK-A nrPDB Length = 337 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 96/246 (39%), Gaps = 19/246 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V K+ ++ + +G GGFGE+ T + A K ++ + + E +L+K Sbjct: 53 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKK 107 Query: 241 VNSQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + + V + +V+ + G +L + F L +IL + Sbjct: 108 LQGKDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESI 166 Query: 300 EDLHRENTVYRDLKPENI----LLDDYGHIRISDLGLAVKIPEGD-------LIRGRVGT 348 E +H ++RD+KP N L Y + D GLA + + G GT Sbjct: 167 EAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGT 226 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY 408 V Y + N+ G D W L ++ E GQ P+R K+K + + + E + Sbjct: 227 VRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK-YEHRMLL 285 Query: 409 SHKFSE 414 H SE Sbjct: 286 KHMPSE 291 >4NFN-A nrPDB Length = 309 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 96/246 (39%), Gaps = 19/246 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V K+ ++ + +G GGFGE+ T + A K ++ + + E +L+K Sbjct: 18 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKK 72 Query: 241 VNSQ-FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 + + V + +V+ + G +L + F L +IL + Sbjct: 73 LQGKDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESI 131 Query: 300 EDLHRENTVYRDLKPENI----LLDDYGHIRISDLGLAVKIPEGD-------LIRGRVGT 348 E +H ++RD+KP N L Y + D GLA + + G GT Sbjct: 132 EAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGT 191 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVY 408 V Y + N+ G D W L ++ E GQ P+R K+K + + + E + Sbjct: 192 VRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK-YEHRMLL 250 Query: 409 SHKFSE 414 H SE Sbjct: 251 KHMPSE 256 >2CHL-A nrPDB Length = 351 Score = 164 bits (415), Expect = 1e-40, Method: Composition-based stats. Identities = 53/264 (20%), Positives = 109/264 (41%), Gaps = 29/264 (10%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F + FR + +G G FGE+ + T + A K + + Sbjct: 16 ENLYFQSMG-------VLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPM 65 Query: 223 KKRKGESMALNEKQILEKVNS-QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP 281 K R + E + +++ S + + Y +VL ++ G L+ ++++ + Sbjct: 66 KSRAPQLHL--EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELL-GPSLED-LFDLCDR 121 Query: 282 GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH-----IRISDLGLAVKI 336 F + L A +++ +E +H +N +YRD+KPEN L+ G+ I I D LA + Sbjct: 122 TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 Query: 337 PEGDL--------IRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 + + + GT YM+ + D LG + + G P++G Sbjct: 182 IDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGL 241 Query: 389 KEKVKREEVDRRVLETEEVYSHKF 412 K +E +++ +T+ + Sbjct: 242 KADTLKERY-QKIGDTKRATPIEV 264 >4RT7-A nrPDB Length = 415 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 53/225 (23%), Positives = 91/225 (40%), Gaps = 25/225 (11%) Query: 233 NEKQILEKVNSQFVVNLAY-AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 E QI +S + L ++ ++D + N L+ E L + Sbjct: 198 REVQI--HPDSDQISGLHGNSFHSEDEI----EYENQKRLEE---EEDLNVLTFEDLLCF 248 Query: 292 AAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR---VGT 348 A ++ G+E L ++ V+RDL N+L+ ++I D GLA I R Sbjct: 249 AYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLP 308 Query: 349 VGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEV 407 V +MAPE L Y + D W G L++E+ G +P+ G ++ + + ++ Sbjct: 309 VKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQP 368 Query: 408 YSHKFSEEAKSICKMLLTKDAKQR---------LGCQEEGAAEVK 443 + +EE I + D+++R LGCQ A E Sbjct: 369 FYA--TEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAM 411 Score = 105 bits (262), Expect = 6e-23, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 56/143 (39%), Gaps = 16/143 (11%) Query: 163 DSMFF-DRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-----MYACKR 216 D+ +F F ++++ + + +VLG G FG+V K A K Sbjct: 43 DNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKM 102 Query: 217 LEKKRIKKRKGESMALNEKQILEKVN-SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI 275 L++K + ++E +++ ++ + +VNL A + L+ GDL ++ Sbjct: 103 LKEKADSSER--EALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYL 160 Query: 276 YNMGNP-------GFEEERALFY 291 + F+E FY Sbjct: 161 RSKREKFHRTWTEIFKEHNFSFY 183 >2C47-A nrPDB Length = 313 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 57/255 (22%), Positives = 107/255 (41%), Gaps = 25/255 (9%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN-S 243 FR + +G G FGE+ + T + A K + IK R + E + ++++ + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL--EYRFYKQLSAT 59 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + V + Y +VL ++ G L+ ++++ + F + L A +++ +E +H Sbjct: 60 EGVPQVYYFGPCGKYNAMVLELL-GPSLED-LFDLCDRTFTLKTVLMIAIQLITRMEYVH 117 Query: 304 RENTVYRDLKPENILLDDYGH-----IRISDLGLAVKIPEGDL--------IRGRVGTVG 350 ++ +YRD+KPEN L+ G I I D GLA + + + + GT Sbjct: 118 TKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 177 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR----RVLETEE 406 YM+ + D LG + + G P++G K +E + + E Sbjct: 178 YMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIE 237 Query: 407 VYSHKFSEEAKSICK 421 V F EE + + Sbjct: 238 VLCENFPEEMATYLR 252 >3SOC-A nrPDB Length = 322 Score = 162 bits (409), Expect = 6e-40, Method: Composition-based stats. Identities = 61/313 (19%), Positives = 102/313 (32%), Gaps = 64/313 (20%) Query: 163 DSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI 222 ++++F + V +G FG V Q+ + A K + Sbjct: 17 ENLYFQSM--------------PLQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDK 60 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKD----ALCLVLTIMNGGDLKFHIYNM 278 + + E E L + + ++ A + L L+ G L + Sbjct: 61 QSWQNEY----EVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN 116 Query: 279 GNPGFEEERALFYAAEILCGLEDLHR----------ENTVYRDLKPENILLDDYGHIRIS 328 A + GL LH +RD+K +N+LL + I+ Sbjct: 117 ---VVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIA 173 Query: 329 DLGLAVKIPEGDL---IRGRVGTVGYMAPEVLNN-----QRYGLSPDYWGLGCLIYEMIE 380 D GLA+K G G+VGT YMAPEVL + L D + +G +++E+ Sbjct: 174 DFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELAS 233 Query: 381 GQ-----------SPFRGRK------EKVKREEVDRRVLETEEVYSHKFSEEAK--SICK 421 PF E ++ V ++ Y K + A + Sbjct: 234 RCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIE 293 Query: 422 MLLTKDAKQRLGC 434 DA+ RL Sbjct: 294 ECWDHDAEARLSA 306 >3HNG-A nrPDB Length = 360 Score = 160 bits (406), Expect = 1e-39, Method: Composition-based stats. Identities = 40/161 (24%), Positives = 65/161 (40%), Gaps = 6/161 (3%) Query: 280 NPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG 339 E + Y+ ++ G+E L ++RDL NILL + ++I D GLA I + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 340 DLIRGRVGTV---GYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKRE 395 + T +MAPE + ++ Y D W G L++E+ G SP+ G + Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFC 312 Query: 396 EVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQE 436 R + + E I +D K+R E Sbjct: 313 SRLREGMRM--RAPEYSTPEIYQIMLDCWHRDPKERPRFAE 351 Score = 85.8 bits (211), Expect = 4e-17, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 46/122 (37%), Gaps = 9/122 (7%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCAC-----QVRATGKMYACKRLEKKRIKKRKGESMAL 232 + + + + LG+G FG+V + T + A K L++ + Sbjct: 21 KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEY--KALM 78 Query: 233 NEKQILEKVNSQ-FVVNLAYAYE-TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF 290 E +IL + VVNL A L +++ G+L ++ + + F + A Sbjct: 79 TELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAAL 138 Query: 291 YA 292 + Sbjct: 139 HM 140 >5X18-A nrPDB Length = 295 Score = 160 bits (405), Expect = 2e-39, Method: Composition-based stats. Identities = 51/260 (19%), Positives = 102/260 (39%), Gaps = 30/260 (11%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN-EKQI 237 + ++ + +G+G FG + G A K + RK E+ L E + Sbjct: 2 STIVGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIK------FEPRKTEAPQLRDEYKT 55 Query: 238 LEKVNS-QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 + +N + Y + LV+ ++ G L+ +++ F + + A +++ Sbjct: 56 YKILNGTPNIPYAYYFGQEGLHNILVIDLL-GPSLED-LFDWCGRKFSVKTVVQVAVQMI 113 Query: 297 CGLEDLHRENTVYRDLKPENILLDDYGH-----IRISDLGLAVKIPEGDL--------IR 343 +EDLH + +YRD+KP+N L+ G I + D G+A + + + Sbjct: 114 TLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKK 173 Query: 344 GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 GT YM+ + D LG + + + G P++G K +++ Sbjct: 174 SLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKY------ 227 Query: 404 TEEVYSHKFSEEAKSICKML 423 E++ K S + + L Sbjct: 228 -EKIGEKKRSTNVYDLAQGL 246 >3VHK-A nrPDB Length = 368 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 46/169 (27%), Positives = 72/169 (42%), Gaps = 15/169 (8%) Query: 283 FEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI 342 E + Y+ ++ G+E L ++RDL NILL + ++I D GLA I + D Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK-DPD 255 Query: 343 RGRVG----TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEV 397 R G + +MAPE + ++ Y + D W G L++E+ G SP+ G K EE Sbjct: 256 YVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKID---EEF 312 Query: 398 DRRVLETEE-VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRH 445 RR+ E + E + QR +E+ H Sbjct: 313 CRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR-----PTFSELVEH 356 Score = 87.3 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 47/124 (37%), Gaps = 9/124 (7%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCAC----QVR-ATGKMYACKRLEKKRIKKRKGESMAL 232 + ++ + + LG+G FG+V + AT + A K L++ + Sbjct: 23 KWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE--HRALM 80 Query: 233 NEKQILEKVNSQ-FVVNLAYAYETK-DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF 290 +E +IL + VVNL A L +++ G+L ++ + N + Sbjct: 81 SELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGA 140 Query: 291 YAAE 294 + Sbjct: 141 RFRQ 144 >3G2F-A nrPDB Length = 336 Score = 158 bits (400), Expect = 6e-39, Method: Composition-based stats. Identities = 61/316 (19%), Positives = 105/316 (33%), Gaps = 67/316 (21%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE--KV 241 + + ++G+G +G V + + A K +NEK I + Sbjct: 13 DNLKLLELIGRGRYGAVYKGSL--DERPVAVKVF------SFANRQNFINEKNIYRVPLM 64 Query: 242 NSQFVVNLAYAYET-----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 + E + LV+ G L ++ + + + A + Sbjct: 65 EHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS---DWVSSCRLAHSVT 121 Query: 297 CGLEDLH---------RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR---- 343 GL LH + +RDL N+L+ + G ISD GL++++ L+R Sbjct: 122 RGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEE 181 Query: 344 -----GRVGTVGYMAPEVLNN-------QRYGLSPDYWGLGCLIYEMIEGQS-PFRGRKE 390 VGT+ YMAPEVL + D + LG + +E+ + F G Sbjct: 182 DNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESV 241 Query: 391 KVKREEVDRRVLETE------------------EVYSHKFSEEAKSI---CKMLLTKDAK 429 + V + S +S+ + +DA+ Sbjct: 242 PEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAE 301 Query: 430 QRLG--CQEEGAAEVK 443 RL C EE AE+ Sbjct: 302 ARLTAQCAEERMAELM 317 >4XHH-A nrPDB Length = 403 Score = 155 bits (391), Expect = 6e-38, Method: Composition-based stats. Identities = 48/229 (20%), Positives = 97/229 (42%), Gaps = 17/229 (7%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 FR R +G G FG++ +G+ A RLE R + + + + K + V Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYKYLSGGV 63 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 F+ + + +V+ ++ G L+ ++N + F + + A +++C ++ Sbjct: 64 GIPFI---RWFGREGEYNAMVIDLL-GPSLED-LFNYCHRKFSFKTVIMLALQMICRVQY 118 Query: 302 LHRENTVYRDLKPENILLD---DYGHIRISDLGLAVKIPEGDLIR--------GRVGTVG 350 +H + ++RD+KP+N L+ + + D GL+ K + + R GT Sbjct: 119 IHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTAR 178 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 Y + D LG ++ +G P++G K K+++ DR Sbjct: 179 YASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDR 227 >4NT4-A nrPDB Length = 312 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 54/261 (20%), Positives = 99/261 (37%), Gaps = 31/261 (11%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ 244 FR + +G G FGE+ + + A K + +K + + E + + + S Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM---EPMKSKAPQLHL--EYRFYKLLGSH 67 Query: 245 ------FVVNLAYAYETKDALC-LVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 + + + +VL ++ G L+ ++N+ F + L A ++L Sbjct: 68 ADNAPDGIPRIYHLGTCGGRYNAMVLELL-GLSLED-LFNICARKFSLKTVLMIAKQLLH 125 Query: 298 GLEDLHRENTVYRDLKPENILLDDYGH-----IRISDLGLAVKIPEGDL--------IRG 344 +E +H + +YRD+KPEN L+ I I D GLA + + D + Sbjct: 126 RIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKS 185 Query: 345 RVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR----R 400 GT YM+ + D LG + + G P++G K +E + + Sbjct: 186 LTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 245 Query: 401 VLETEEVYSHKFSEEAKSICK 421 EV EE + + Sbjct: 246 RATPIEVLCDGHPEEFATYLR 266 >4XHL-A nrPDB Length = 394 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 50/253 (19%), Positives = 104/253 (41%), Gaps = 24/253 (9%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 FR R +G G FG++ +G+ A RLE R + + + + + + V Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYRYLSGGV 63 Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301 F+ + + +V+ ++ G L+ ++N + F + + A ++ C ++ Sbjct: 64 GIPFI---RWFGREGEYNAMVIDLL-GPSLED-LFNYCHRRFSFKTVIMLALQMFCRIQY 118 Query: 302 LHRENTVYRDLKPENILLD---DYGHIRISDLGLAVKIPEGDLIR--------GRVGTVG 350 +H + ++RD+KP+N L+ + + D GL+ K + + R GT Sbjct: 119 IHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTAR 178 Query: 351 YMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 Y + D LG ++ +G P++G K K+++ DR + Sbjct: 179 YASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDR-------IMEK 231 Query: 411 KFSEEAKSICKML 423 K + +++C L Sbjct: 232 KLNVSVETLCSGL 244 >2PZI-A nrPDB Length = 681 Score = 151 bits (381), Expect = 9e-37, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 103/269 (38%), Gaps = 27/269 (10%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRA-TGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + + + GG G + R G+ K L + + +MA Q L Sbjct: 76 DIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFL 133 Query: 239 EKVNSQFVVNLAYAYETKDAL-----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 +V +V + E D +V+ + G LK A+ Y Sbjct: 134 AEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK----RSKGQKLPVAEAIAYLL 189 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMA 353 EIL L LH VY DLKPENI+L + +++ DLG +I + GT G+ A Sbjct: 190 EILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY---GTPGFQA 245 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 PE++ ++ D + +G + + GR E D VL+T + Y Sbjct: 246 PEIVRTGP-TVATDIYTVGRTLAALTLDLPTRNGRYVDGLPE--DDPVLKTYDSYGR--- 299 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEV 442 + + + D +QR EE +A++ Sbjct: 300 -----LLRRAIDPDPRQRFTTAEEMSAQL 323 >4Y12-A nrPDB Length = 375 Score = 151 bits (381), Expect = 1e-36, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 103/269 (38%), Gaps = 27/269 (10%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRA-TGKMYACKRLEKKRIKKRKGESMALNEKQIL 238 + + + GG G + R G+ K L + + +MA Q L Sbjct: 115 DIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFL 172 Query: 239 EKVNSQFVVNLAYAYETKDAL-----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 +V +V + E D +V+ + G LK A+ Y Sbjct: 173 AEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK----RSKGQKLPVAEAIAYLL 228 Query: 294 EILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMA 353 EIL L LH VY DLKPENI+L + +++ DLG +I + GT G+ A Sbjct: 229 EILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY---GTPGFQA 284 Query: 354 PEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 PE++ ++ D + +G + + GR E D VL+T + Y Sbjct: 285 PEIVRTGP-TVATDIYTVGRTLAALTLDLPTRNGRYVDGLPE--DDPVLKTYDSYGR--- 338 Query: 414 EEAKSICKMLLTKDAKQRLGCQEEGAAEV 442 + + + D +QR EE +A++ Sbjct: 339 -----LLRRAIDPDPRQRFTTAEEMSAQL 362 >2QLU-A nrPDB Length = 314 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 56/297 (18%), Positives = 102/297 (34%), Gaps = 53/297 (17%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 V + + + + +G FG V Q+ A K + + + E E Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSE----REIFSTPG 65 Query: 241 VNSQFVVNLAYAYETKD----ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 + + ++ A + L L+ + G L ++ A + Sbjct: 66 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGN---IITWNELCHVAETMS 122 Query: 297 CGLEDLHR-----------ENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL---I 342 GL LH + +RD K +N+LL ++D GLAV+ G Sbjct: 123 RGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDT 182 Query: 343 RGRVGTVGYMAPEVLNN-----QRYGLSPDYWGLGCLIYEMIE----------------- 380 G+VGT YMAPEVL + L D + +G +++E++ Sbjct: 183 HGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFE 242 Query: 381 ---GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGC 434 GQ P ++V + R ++ + ++ + + DA+ RL Sbjct: 243 EEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVT-IEECWDHDAEARLSA 298 >1CSN-A nrPDB Length = 298 Score = 145 bits (365), Expect = 7e-35, Method: Composition-based stats. Identities = 46/257 (17%), Positives = 97/257 (37%), Gaps = 28/257 (10%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI 237 + V ++ R +G+G FG + + A K +R +E + Sbjct: 4 QNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKF-----EPRRSDAPQLRDEYRT 58 Query: 238 LEKV-NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEIL 296 + + + N+ Y + LV+ ++ G L+ + ++ F + A ++L Sbjct: 59 YKLLAGCTGIPNVYYFGQEGLHNVLVIDLL-GPSLEDLL-DLCGRKFSVKTVAMAAKQML 116 Query: 297 CGLEDLHRENTVYRDLKPENILL-----DDYGHIRISDLGLAVKIPE--------GDLIR 343 ++ +H ++ VYRD+KP+N L+ + I + D G+ + + Sbjct: 117 ARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKK 176 Query: 344 GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403 GT YM+ + D LG + + G P++G K +++ +R Sbjct: 177 NLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYER---- 232 Query: 404 TEEVYSHKFSEEAKSIC 420 + K S + +C Sbjct: 233 ---IGEKKQSTPLRELC 246 >5X1R-A nrPDB Length = 302 Score = 141 bits (356), Expect = 8e-34, Method: Composition-based stats. Identities = 47/279 (16%), Positives = 89/279 (31%), Gaps = 28/279 (10%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGE--------------- 228 N F +G+GGFG V + A K + KR + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 229 ---SMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEE 285 + + E ++L + + ++++ +E + +G LK + +E Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKN-LQAQQPEKIDE 139 Query: 286 ERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRG 344 + + +H+E ++RD+ +NI + + + D G A K I Sbjct: 140 AWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETE 199 Query: 345 RVGTVGYMAPEVLNNQRYGLS---PDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV 401 V G+ E G D + LG +++ +I G P ++ Sbjct: 200 IVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVRSIEDSY 254 Query: 402 LETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAA 440 E +S E L + R +E A Sbjct: 255 QPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAE 293 >4M69-B nrPDB Length = 283 Score = 137 bits (346), Expect = 1e-32, Method: Composition-based stats. Identities = 39/251 (15%), Positives = 84/251 (33%), Gaps = 22/251 (8%) Query: 198 GEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN-EKQILEKVNSQFVVNLAYAYETK 256 + + + K + + N E + ++K +S ++ + + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 257 D----ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDL 312 +V+ G L+ + + GL LH T++R++ Sbjct: 81 TVKPPEFSIVMEYCELGTLRELLDREKD--LTMSVRSLLVLRAARGLYRLHHSETLHRNI 138 Query: 313 KPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG-------YMAPEVLNN--QRYG 363 + L+ ++++ L+ + + R T Y++PE L N Y Sbjct: 139 SSSSFLVAGGYQVKLAGFELSK--TQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYD 196 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 + + + G +++E+ G+ PF G K RE V + +E E + I Sbjct: 197 IKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAED--KKQEPVGQDCPELLREIINEC 254 Query: 424 LTKDAKQRLGC 434 + QR Sbjct: 255 RAHEPSQRPSV 265 >4BTF-A nrPDB Length = 469 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 39/251 (15%), Positives = 84/251 (33%), Gaps = 22/251 (8%) Query: 198 GEVCACQVRATGKMYACKRLEKKRIKKRKGESMALN-EKQILEKVNSQFVVNLAYAYETK 256 + + + K + + N E + ++K +S ++ + + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 257 D----ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDL 312 +V+ G L+ + + GL LH T++R++ Sbjct: 267 TVKPPEFSIVMEYCELGTLRELLDREKD--LTMSVRSLLVLRAARGLYRLHHSETLHRNI 324 Query: 313 KPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG-------YMAPEVLNN--QRYG 363 + L+ ++++ L+ + + R T Y++PE L N Y Sbjct: 325 SSSSFLVAGGYQVKLAGFELSK--TQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYD 382 Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423 + + + G +++E+ G+ PF G K RE V + +E E + I Sbjct: 383 IKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAED--KKQEPVGQDCPELLREIINEC 440 Query: 424 LTKDAKQRLGC 434 + QR Sbjct: 441 RAHEPSQRPSV 451 >5M07-A nrPDB Length = 276 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 45/266 (16%), Positives = 80/266 (30%), Gaps = 29/266 (10%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 VT + R+LG GEV Q A K L + E ++ + Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAAR 86 Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 + ++ + E L + + ++G D H+ + L + L+ Sbjct: 87 LFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALD 146 Query: 301 DLHRENTVYRDLKPENILLDDYG----HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV 356 H+ ++RD+ P N++L I ++D G+A + Y APE+ Sbjct: 147 YAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPEL 193 Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416 D + L + G P + S + A Sbjct: 194 SAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQ----------PPKLSAFRPDLA 243 Query: 417 K--SICKMLLTKDAKQRLGCQEEGAA 440 + + L R G E A Sbjct: 244 RLDGVLSRALATAPADRFGSCREFAD 269 >5USZ-A nrPDB Length = 289 Score = 135 bits (341), Expect = 4e-32, Method: Composition-based stats. Identities = 45/272 (16%), Positives = 95/272 (34%), Gaps = 29/272 (10%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKRLEKKRIKKRKGESMALN 233 + LG+G F ++ R G K L+K R Sbjct: 5 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAH---RNYSESFFE 61 Query: 234 EKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 ++ K++ + +V D LV + G L ++ N L A Sbjct: 62 AASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNC-INILWKLEVAK 120 Query: 294 EILCGLEDLHRENTVYRDLKPENILL--------DDYGHIRISDLGLAVKIPEGDLIRGR 345 ++ + L ++ ++ +NILL + I++SD G+++ + D+++ R Sbjct: 121 QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER 180 Query: 346 VGTVGYMAPEVLNN-QRYGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLE 403 + ++ PE + N + L+ D W G ++E+ G P + K + + R Sbjct: 181 ---IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDR--- 234 Query: 404 TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQ 435 + E ++ + + R + Sbjct: 235 --HQLPAPKAAELANLINNCMDYEPDHRPSFR 264 >5J0A-A nrPDB Length = 300 Score = 135 bits (341), Expect = 4e-32, Method: Composition-based stats. Identities = 49/281 (17%), Positives = 95/281 (33%), Gaps = 37/281 (13%) Query: 190 RVLGKGGFGE-VCACQVRATGKMY---ACKRLEK--KRIKKRKGESMALNEKQILEKVNS 243 + LG G G V + G + A K++ + + ++E +IL+ ++ Sbjct: 15 QKLGFGT-GVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHH 73 Query: 244 QFVVNLAYAYE-TKDALCLVLTIMNGG-----DLKFHIYNMGNPGFEEERALFYAAEILC 297 +V E +LCL + GG DL Y F L A + Sbjct: 74 PNIVGYRAFTEANDGSLCLAMEY--GGEKSLNDLIEERYKASQDPFPAAIILKVALNMAR 131 Query: 298 GLEDLHR-ENTVYRDLKPENILLDDYG-HIRISDLGLAVKIPEGDLIRG----RVGTVGY 351 GL+ LH+ + ++ D+K N+++ I+I D+G+++ + E + +GT + Sbjct: 132 GLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPW 191 Query: 352 MAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKE------------KVKREEVD 398 E + D + G ++EM+ P E Sbjct: 192 KPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYY 251 Query: 399 RRVLETEEVYSHKFSEE---AKSICKMLLTKDAKQRLGCQE 436 + + + E + + +D K R Sbjct: 252 AALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAH 292 >4MWI-A nrPDB Length = 294 Score = 135 bits (341), Expect = 4e-32, Method: Composition-based stats. Identities = 38/258 (14%), Positives = 87/258 (33%), Gaps = 25/258 (9%) Query: 201 CACQVRATGKMYACKRLEKKRIKKRKGESMALN-EKQILEKVNSQFVVNLAYAYETKD-- 257 + A K +K + N E + ++K S ++ + + Sbjct: 41 YKGEYHRA--PVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVT 98 Query: 258 --ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH--RENTVYRDLK 313 +V+ G L+ + + + + GL LH ++ ++ Sbjct: 99 PPQFSIVMEYCELGTLRELLDREKD--LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIR 156 Query: 314 PENILLDDYGHIRISDLGL-----AVKIPEGDLIRGRVGTVGYMAPEVLNN--QRYGLSP 366 N L+ ++++ L ++ + RV + Y++P+ L + +Y + Sbjct: 157 SSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKS 216 Query: 367 DYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTK 426 + + G +++E+ G PF+G + R+ V V +E E + I Sbjct: 217 EIYSFGIVLWEIATGDIPFQGCNSEKIRKLV--AVKRQQEPLGEDCPSELREIIDECRAH 274 Query: 427 DAKQRLGCQEEGAAEVKR 444 D R E+ + Sbjct: 275 DPSVR-----PSVDEILK 287 >3REP-A nrPDB Length = 271 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 95/263 (36%), Gaps = 16/263 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQ 236 + + L + GE+ + + + ++ +K + E Sbjct: 3 KHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD---FNEECP 59 Query: 237 ILEKVNSQFVVNLAYAYETKD--ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 L + V+ + A ++ L+ M G L ++ N ++ +A+ +A + Sbjct: 60 RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD 119 Query: 295 ILCGLEDLHR-ENTVYR-DLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYM 352 + G+ LH E + R L ++++D+ RIS +A + GR+ ++ Sbjct: 120 MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---MA-DVKFSFQSPGRMYAPAWV 175 Query: 353 APEVLNNQRYGL---SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS 409 APE L + S D W L++E++ + PF +V L Sbjct: 176 APEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLR--PTIP 233 Query: 410 HKFSEEAKSICKMLLTKDAKQRL 432 S + K+ + +D +R Sbjct: 234 PGISPHVSKLMKICMNEDPAKRP 256 >5OAT-A nrPDB Length = 411 Score = 132 bits (332), Expect = 5e-31, Method: Composition-based stats. Identities = 56/371 (15%), Positives = 116/371 (31%), Gaps = 95/371 (25%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM-----YACKRLEKKRIKKRKGESM 230 E P+T N + + KG G V + +V+ +A K + I++ E + Sbjct: 3 FESNPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEIL 62 Query: 231 ALN-------------------EKQILEKVNS----QFVVNLAYAYET------------ 255 E ++ + +V + + Sbjct: 63 KAMYRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHP 122 Query: 256 -----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYR 310 +L L++ + +L+ + + G+ + +R Sbjct: 123 EGEGRNMSLFLLMKRYDC-NLQSFLSTAPSTRTSLLLLAQLL----EGVAHMTAHGIAHR 177 Query: 311 DLKPENILLD----DYGHIRISDLGLA-------VKIPEGDLIRGRVGTVGYMAPEVLNN 359 DLK +N+LLD + + ISD G + +P + G MAPE++ Sbjct: 178 DLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQ 237 Query: 360 QRYGL------SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFS 413 + D W +G + YE+ +PF G ++K L + Sbjct: 238 KPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPS-RLKNFNYKEGDL---PKLPDEVP 293 Query: 414 EEAKSICKMLLTKDAKQRL----------------------GCQEEGAAEVKRHPFFRNM 451 +++ LL ++ +RL G + + E+ + + ++ Sbjct: 294 TVIQALVANLLKRNPNKRLDPEVAANVCQLFLWAPSTWLKPGLKVPTSGEILQ--WLLSL 351 Query: 452 NFKRLEAGMLD 462 K L G ++ Sbjct: 352 TTKVLCEGKIN 362 >4L00-A nrPDB Length = 304 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 50/291 (17%), Positives = 101/291 (34%), Gaps = 45/291 (15%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQ------VRATGKMYACKRLEKKRIKKRKGESMALN 233 + K Q LG+G + + T + K + K + S+A Sbjct: 21 RILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFF 80 Query: 234 EK-QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 E ++ +V+ + +V L +V + GG L ++ + A Sbjct: 81 EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSD-VLTTPWKFKVA 139 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGH-------IRISDLGLAVKIPEGDLIRGR 345 ++ L L ++ V+ ++ +N+LL G I++SD G+ + + R Sbjct: 140 KQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIER 199 Query: 346 VGTVGYMAPEVLNNQR-YGLSPDYWGLGCLIYEMIE-GQSPFRGRKEKVKREEVDRRVLE 403 + ++APE + + + ++ D W G ++E+ G+ P + + K Sbjct: 200 ---IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKE--------R 248 Query: 404 TEEVYSHKFSEEAK---SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNM 451 E + K + + D QR PFFR + Sbjct: 249 FYESRCRPVTPSCKELADLMTRCMNYDPNQR--------------PFFRAI 285 >4L68-A nrPDB Length = 340 Score = 128 bits (322), Expect = 6e-30, Method: Composition-based stats. Identities = 59/267 (22%), Positives = 95/267 (35%), Gaps = 25/267 (9%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS 243 N F ++ G + G A K L ++ GE E L ++ Sbjct: 40 NNFNSENIIVSTRTGTTYKA-LLPDGSALAVKHLSTCKL----GEREFRYEMNQLWELRH 94 Query: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 + L ++ LV M+ G L + + + GL LH Sbjct: 95 SNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLL-DSNRGELDWSTRFRIGLGAARGLAWLH 153 Query: 304 ---RENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-----LIRGRVGTVGYMAPE 355 R +++++ IL+D+ RI D GLA + D + G +G GY+APE Sbjct: 154 HGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE 213 Query: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK------VKREEVDRRVLET--EEV 407 L D +GLG ++ E+ G G K VK+ E R+ ET E + Sbjct: 214 YSTTMLASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENI 273 Query: 408 YSHKFSEEAKSICK---MLLTKDAKQR 431 EE + ++ K+R Sbjct: 274 RGKGHDEEISKFVEIALNCVSSRPKER 300 >4I94-A nrPDB Length = 300 Score = 128 bits (321), Expect = 9e-30, Method: Composition-based stats. Identities = 42/237 (17%), Positives = 85/237 (35%), Gaps = 10/237 (4%) Query: 199 EVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDA 258 V ++ + A KR + K L E + + ++ + + NL + Sbjct: 44 VVYKGKL-ENQRRIAVKRFNR---KSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 259 LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN-TVYRDLKPENI 317 L+ M L H+++ + + L A I LE + +Y DL + Sbjct: 100 RLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 318 LLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYE 377 L DD + R+S GL +G + + PE L R + G L+ + Sbjct: 160 LFDDDANPRLSCFGLMKNSRDGKSYSTN---LAFTPPEYLRTGRVTPESVIYSFGTLLLD 216 Query: 378 MIEGQSPFRGRKEKVKREEVDRRVLET--EEVYSHKFSEEAKSICKMLLTKDAKQRL 432 ++ G+ + R+ + ++++ E +S E + L + ++R Sbjct: 217 LLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERP 273 >6EQI-C nrPDB Length = 433 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 49/330 (14%), Positives = 101/330 (30%), Gaps = 79/330 (23%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG-----KMYACKRLEKKRIKKRKGE--S 229 + Q + + KG V + +++ A K + ++ Sbjct: 8 QLQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILK 67 Query: 230 MALNE---------------KQILEKVN-----SQFVVNLAYAYETKDA----------- 258 E + + +V + + + Sbjct: 68 AMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPE 127 Query: 259 ----------------LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 L LV+ + LK ++ + ++ +++L + + Sbjct: 128 ALPPRINPEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP---NMRSSILLLSQLLEAVAHM 183 Query: 303 HRENTVYRDLKPENILL-----DDYGHIRISDLGLAVK-------IPEGDLIRGRVGTVG 350 + N +RDLK +NIL+ D Y I I+D G + IP + + G Sbjct: 184 NIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRA 243 Query: 351 YMAPEVLNNQRYG------LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET 404 MAPE+ N + D W +G + YE+ +PF + K+ + L Sbjct: 244 LMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDL-- 301 Query: 405 EEVYSHKFSEEAKSICKMLLTKDAKQRLGC 434 +++ +L++ +RL C Sbjct: 302 -PELPDTIPFIIRNLVSNMLSRSTNKRLDC 330 >5C01-A nrPDB Length = 342 Score = 118 bits (295), Expect = 8e-27, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 78/243 (32%), Gaps = 22/243 (9%) Query: 203 CQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLV 262 + R K L+ ++ +V+ + + +V Sbjct: 101 GRDRGQELRVVLKVLDPSH---HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 157 Query: 263 LTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDY 322 + G L + + A ++ L L +N V+ ++ NILL Sbjct: 158 TEYVEHGPLDVWLR-RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 216 Query: 323 GH-------IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ--RYGLSPDYWGLGC 373 G I++SD G+ + + R + ++APE L + D WG G Sbjct: 217 GLAEGTSPFIKLSDPGVGLGALSREERVER---IPWLAPECLPGGANSLSTAMDKWGFGA 273 Query: 374 LIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRL 432 + E+ G++P + R K R + + ++ LT + QR Sbjct: 274 TLLEICFDGEAPLQSRSPSEKEHFYQR-----QHRLPEPSCPQLATLTSQCLTYEPTQRP 328 Query: 433 GCQ 435 + Sbjct: 329 SFR 331 >4WOV-A nrPDB Length = 317 Score = 118 bits (295), Expect = 8e-27, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 78/243 (32%), Gaps = 22/243 (9%) Query: 203 CQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLV 262 + R K L+ ++ +V+ + + +V Sbjct: 78 GRDRGQELRVVLKVLDPSH---HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 134 Query: 263 LTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDY 322 + G L + + A ++ L L +N V+ ++ NILL Sbjct: 135 TEYVEHGPLDVWLR-RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 193 Query: 323 GH-------IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ--RYGLSPDYWGLGC 373 G I++SD G+ + + R + ++APE L + D WG G Sbjct: 194 GLAEGTSPFIKLSDPGVGLGALSREERVER---IPWLAPECLPGGANSLSTAMDKWGFGA 250 Query: 374 LIYEMIE-GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRL 432 + E+ G++P + R K R + + ++ LT + QR Sbjct: 251 TLLEICFDGEAPLQSRSPSEKEHFYQR-----QHRLPEPSCPQLATLTSQCLTYEPTQRP 305 Query: 433 GCQ 435 + Sbjct: 306 SFR 308 >6J6I-B nrPDB Length = 351 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 40/186 (21%), Positives = 64/186 (34%), Gaps = 11/186 (5%) Query: 209 GKMYACKRLEKKRIK-KRKGESMALNEKQI-LEKVNSQFVVNLAYAYETKDALCLVLTIM 266 + Y KR + I KR N+ + N + L LV Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFA 140 Query: 267 NGGDLKFH---IYNMGNPGFEEERALFYAAEILCGLEDLHR---ENTVYRDLKPENILLD 320 G + I N L EI + LH + ++RD+KP ++ LD Sbjct: 141 EHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD 200 Query: 321 DYGHIRISDLGLAVKIPEGDLIRG---RVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYE 377 ++SDL ++ +PEG +GT GY+ P D + G + Sbjct: 201 KNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLV 260 Query: 378 MIEGQS 383 +I G+ Sbjct: 261 IITGKP 266 >4JRN-A nrPDB Length = 372 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 47/297 (15%), Positives = 89/297 (29%), Gaps = 55/297 (18%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN--------- 242 LG GGF V T + A K ++ + E + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 243 --SQFVVNLAYAYETKDA----------------LCLVLTIMNGGDLKFHIY------NM 278 +F+V L++ D+ I ++ Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEA-DMSKVISWVFGDASV 194 Query: 279 GNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE 338 F ++ +++ + + ++ + V+ D+KP N LL G + + D G Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG---TYRI 251 Query: 339 GDLIRGRVGTVGYMAPEV---LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE 395 + + +GT GY PE Y D W LG +Y + + P Sbjct: 252 NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLH 311 Query: 396 EVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMN 452 D E + + + LL +D ++R+ + F+ M+ Sbjct: 312 FAD----------CPSTPELVQDLIRSLLNRDPQKRMLPLQALETAA-----FKEMD 353 >5UV4-A nrPDB Length = 311 Score = 111 bits (278), Expect = 9e-25, Method: Composition-based stats. Identities = 38/204 (18%), Positives = 76/204 (37%), Gaps = 15/204 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 ++G+ G + G M K L++ K +K E + L V +V L Sbjct: 31 EIIGRSCHGTSYKATL-DNGYMLTVKWLKEGFAKSKKE---FSREIKKLGSVRHPNLVPL 86 Query: 250 --AYAYETKDALCLVLTIMNGGDLKFHIYN---MGNPGFEEERALFYAAEILCGLEDLHR 304 Y + ++ + L ++ P + L A +I L+ LH Sbjct: 87 RGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHN 146 Query: 305 ENTV-YRDLKPENILL-DDYGHIRISDLGLAVKIPEGDLIRG--RVGTVGYMAPEVLNNQ 360 E + + ++K N+L+ + ++D L + + G +GY PE + Sbjct: 147 ERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTS 206 Query: 361 RY--GLSPDYWGLGCLIYEMIEGQ 382 + L D + G ++ E++ G+ Sbjct: 207 KPCPSLKSDVYAFGVILLELLTGK 230 >5DMZ-A nrPDB Length = 365 Score = 99.6 bits (247), Expect = 4e-21, Method: Composition-based stats. Identities = 49/256 (19%), Positives = 95/256 (37%), Gaps = 36/256 (14%) Query: 158 FHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVL-------GKGGFGEVCACQ-----V 205 + + S Q K +P T F+ L G+G F +V Sbjct: 34 LSKPVSSYPNTFEWQCKLPAIKPKT--EFQLGSKLVYVHHLLGEGAFAQVYEATQGDLND 91 Query: 206 RATGKMYACKRLEKKRIKKRKGESMALNEKQILE-KVNSQFVVNLAYAYETKDALCLVLT 264 + + K ++K L E+ L+ + F + A+ ++ LV Sbjct: 92 AKNKQKFVLK-VQKPANPWEFYIGTQLMER--LKPSMQHMF-MKFYSAHLFQNGSVLVGE 147 Query: 265 IMNGGDLKFHI---YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD 321 + + G L I N + + +A +L +E +H ++ D+KP+N +L + Sbjct: 148 LYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGN 207 Query: 322 YGH-----------IRISDLGLA---VKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPD 367 + + DLG + P+G + + T G+ E+L+N+ + D Sbjct: 208 GFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQID 267 Query: 368 YWGLGCLIYEMIEGQS 383 Y+G+ +Y M+ G Sbjct: 268 YFGVAATVYCMLFGTY 283 >5CLR-A nrPDB Length = 451 Score = 98.1 bits (243), Expect = 8e-21, Method: Composition-based stats. Identities = 49/219 (22%), Positives = 80/219 (36%), Gaps = 29/219 (13%) Query: 201 CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAY--ETKDA 258 GK Y K ++ + + NEK L K+ L + E Sbjct: 96 FKVYALDDGKTYFLKSVK----IDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQV 146 Query: 259 LCLVLTIMNGGDLKFHI----YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKP 314 ++ T + G DL + N+ F E L + ++ H ++RDLKP Sbjct: 147 HYILTTFIKGIDLSRYKNALPLNVNLKHFWE--VLGIMISVCHQVKQFHELGLIHRDLKP 204 Query: 315 ENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR---YGLSPDYWGL 371 NI+LD + D G + + + GT Y+APE+ + + D + L Sbjct: 205 GNIMLDADMQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFAL 262 Query: 372 GCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 + E+ PFR +VK +VD + V H Sbjct: 263 AYSLDELFN---PFR----QVKFAKVDIGIKNKHLVLLH 294 >5UU1-A nrPDB Length = 324 Score = 93.5 bits (231), Expect = 3e-19, Method: Composition-based stats. Identities = 39/235 (16%), Positives = 88/235 (37%), Gaps = 36/235 (15%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQ-----VRATGKMYACKR------LEKKRIKKRKGE 228 + N + + +G GGFG + + + + + + +R + Sbjct: 12 DMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAK 71 Query: 229 SMALN---EKQILEKVNSQFVVNLAYA-----YETKDALCLVLTIMNGGDLKFHIYNMGN 280 + E++ L+ + L Y ++ + +V+ + G DL+ + N Sbjct: 72 KDCIKKWIERKQLDYLGIP----LFYGSGLTEFKGRSYRFMVMERL-GIDLQKI--SGQN 124 Query: 281 PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILL--DDYGHIRISDLGLAVKI-- 336 F++ L +L LE +H V+ D+K N+LL + + ++D GL+ + Sbjct: 125 GTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCP 184 Query: 337 ------PEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPF 385 + + +G GT+ + + + D LG + + G+ P+ Sbjct: 185 NGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW 239 >4O1O-A nrPDB Length = 717 Score = 92.7 bits (229), Expect = 4e-19, Method: Composition-based stats. Identities = 64/414 (15%), Positives = 134/414 (32%), Gaps = 79/414 (19%) Query: 80 YIQFLDSVAEYEVTPDEKLGEKGKEIMTKY-LTPKSPVFIAQVGQDLVSQTEEKLLQKPC 138 +Q L + EV ++ G+ + + L + + + + L+ Sbjct: 237 LVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCH---RGASTNC-GDLVAIAR 292 Query: 139 KELFSACAQSVHEYLRGEPFHEYLDSMFFDR----------FLQWKWL--ERQPVTKNTF 186 + S + + + GE F ++ W+ + + + + Sbjct: 293 RNYDSDLVKFLRLHKAGEDFRPPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEY 352 Query: 187 RQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN-SQF 245 + +GG + + A KR + + ++ E L+ + Sbjct: 353 KIADT-AEGG---IYLGLY--EDQEVAVKRFSEGSTRGQQ-------EVSCLQSSRANDN 399 Query: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGN---PGFEEERALFYAAEILCGLEDL 302 VV + L + L + L+ H+ N P E+E A + + + +L Sbjct: 400 VVTFYGSESDGSCLHVCLALCEY-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGEL 458 Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 HR ++DL+P+NIL+D ++D ++K E Sbjct: 459 HRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAED---------------------PQ 497 Query: 363 GLSPDYWGLG-CLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421 + D LG ++Y + +G F K + EEV + + EE + + Sbjct: 498 KIKRDLEALGLLVLYVVKKGDISFETLKNQ-SFEEVIQGSPD----------EETRDLIH 546 Query: 422 MLLTK--DAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVY 473 L + + RL + HPFF +++ + D D + Sbjct: 547 HLFHPGDNVEDRLSS-------LLAHPFF--WSWESRYRTLRDVGNESDIKTRN 591 >2RSV-A nrPDB Length = 403 Score = 89.2 bits (220), Expect = 5e-18, Method: Composition-based stats. Identities = 43/240 (17%), Positives = 79/240 (32%), Gaps = 39/240 (16%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY------ACKRLEKK------------R 221 + K ++ +G+GGFG + + + K R Sbjct: 38 DMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 96 Query: 222 IKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKD----ALCLVLTIMNGGDLKFHIYN 277 K + + ++ L+ + + +++ G IY Sbjct: 97 AAKPEQIQKWIRTRK-LKYLGVP---KYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYE 150 Query: 278 MGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLD--DYGHIRISDLGLA-V 334 F + L + IL LE +H V+ D+K N+LL+ + + + D GLA Sbjct: 151 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 210 Query: 335 KIPEG-------DLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 PEG D R GT+ + + + N D LG + + + G P+ Sbjct: 211 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 270 >2LAV-A nrPDB Length = 361 Score = 88.9 bits (219), Expect = 5e-18, Method: Composition-based stats. Identities = 43/240 (17%), Positives = 79/240 (32%), Gaps = 39/240 (16%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY------ACKRLEKK------------R 221 + K ++ +G+GGFG + + + K R Sbjct: 31 DMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 Query: 222 IKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKD----ALCLVLTIMNGGDLKFHIYN 277 K + + ++ L+ + + +++ G IY Sbjct: 90 AAKPEQIQKWIRTRK-LKYLGVP---KYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYE 143 Query: 278 MGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLD--DYGHIRISDLGLA-V 334 F + L + IL LE +H V+ D+K N+LL+ + + + D GLA Sbjct: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 Query: 335 KIPEG-------DLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 PEG D R GT+ + + + N D LG + + + G P+ Sbjct: 204 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 >4IX6-A nrPDB Length = 350 Score = 85.0 bits (209), Expect = 9e-17, Method: Composition-based stats. Identities = 57/326 (17%), Positives = 92/326 (28%), Gaps = 84/326 (25%) Query: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF----VV 247 LG G FG V + + L+ + E + E + V Sbjct: 28 LGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV-HANAKGTCA 82 Query: 248 NLAYAYE----TKDALC--LVLT---IM---NGGDLKFHIYNMGNPGFEEERA------- 288 E + + +M G + + G A Sbjct: 83 RFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATEL 142 Query: 289 ---LFYAAEILCGLEDLHRENTVYRDLKPENILL---DDYGHIRISDLG---LAVKIPEG 339 E+L L LH V+RD+KP N L+ D G +++ DLG L + +PE Sbjct: 143 GVTKKAMRELLGSLARLHECGVVHRDVKPAN-LIAAEKDGGVLKLIDLGAAALCLPLPET 201 Query: 340 DLIRGRVGT--VGY--------MAP--------------EVLNNQRYGLSPDYWGLGCLI 375 G Y + P E R+ D W GC++ Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRF----DSWSAGCVM 257 Query: 376 YEMIE-------GQSPFRGRKEKVKRE-EVDRRVLETEEVYSHKFSEEAK-----SICKM 422 ++ G F + V + R E + +A +C+ Sbjct: 258 LQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGWDLCQR 317 Query: 423 LLTKDAKQRLGCQEEGAAEVKRHPFF 448 L+ + R C+ H FF Sbjct: 318 LMEAERDARASCEA-----ALSHAFF 338 >6EAS-A nrPDB Length = 308 Score = 84.2 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 46/270 (17%), Positives = 90/270 (33%), Gaps = 39/270 (14%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI--LEKVNSQFVVN 248 ++G + + ++G A K E+ + K+I L KV+ + +N Sbjct: 47 IIGSTSTCMLYKGTL-SSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMN 105 Query: 249 LAYAYETKDAL--CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHREN 306 L E + +V G L H++ + L + I LE +H+ Sbjct: 106 LLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQ-- 163 Query: 307 TVYRDL----KPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY 362 L N D + ++D A K+ + + G N Sbjct: 164 -----LQTPAALRNF---DSTTVYLTD-DFAAKVSDLEFWNDAKGH------NSTTNNEL 208 Query: 363 GLSPDYW----GLGCLIYEMIEGQSPFRGRKEKVKR--EEVDRRVLETEEVYSHKF---- 412 SPD G ++ E++ G+ P ++ + EE+ Sbjct: 209 AFSPDMEDIVRKYGMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFP 268 Query: 413 SEEAKSIC---KMLLTKDAKQRLGCQEEGA 439 + A+++C + + +D K+R +E A Sbjct: 269 EDTARALCEVVRSCIDRDPKKRPQMKEVAA 298 >4OAU-C nrPDB Length = 699 Score = 79.2 bits (194), Expect = 5e-15, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 87/263 (33%), Gaps = 55/263 (20%) Query: 198 GEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN-SQFVVNLAYAYETK 256 G + + A K + + + E L+ + +V + + Sbjct: 357 GGIYLGFY--EKQEVAVKTFCEGSPRAQ-------REVSCLQSSRENSHLVTFYGSESHR 407 Query: 257 DALCLVLTIMNGGDLKFHI-YNMGNPGFEEER--ALFYAAEILCGLEDLH-RENTVYRDL 312 L + +T+ L+ + + G EE A + I +++LH ++DL Sbjct: 408 GHLFVCVTLCE-QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 466 Query: 313 KPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLG 372 +P+NIL+D ++D ++K + D LG Sbjct: 467 QPQNILIDSKKAAHLADFDKSIKWA---------------------GDPQEVKRDLEDLG 505 Query: 373 -CLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQR 431 ++Y + +G F K + E V ++ EE K + L R Sbjct: 506 RLVLYVVKKGSISFEDLKAQSNEEVV--------QLSPD---EETKDLIHRLFHPGEHVR 554 Query: 432 LGCQEEGAAEVKRHPFFRNMNFK 454 + +++ HPFF ++ Sbjct: 555 -----DCLSDLLGHPFF--WTWE 570 >6EWX-A nrPDB Length = 484 Score = 76.1 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 45/237 (18%), Positives = 79/237 (33%), Gaps = 51/237 (21%) Query: 254 ETKDALCLVLTIMNGGDLKFHIYN-----MGNPGFEEERALFYAAEILCGLEDLHRENTV 308 + +D + ++ + + + P E R F ++ GLE L + Sbjct: 173 QEQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGII 232 Query: 309 YRDLKPENILL-----------------------------------------DDYGHIRI 327 +RDL EN+LL + I Sbjct: 233 HRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLII 292 Query: 328 SDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRG 387 S+ A + P G + + +APE+++ +Y D + G LIYE++ +PF Sbjct: 293 SNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY-RKFDEFQTGILIYELLHQPNPF-- 349 Query: 388 RKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKR 444 RE RR +S + + +LL D +R+ E A V + Sbjct: 350 EVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGE--AKRVLQ 404 >6G4J-A nrPDB Length = 315 Score = 74.2 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 31/160 (19%), Positives = 59/160 (36%), Gaps = 26/160 (16%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 NT+ + LGKG G V + + G A K +E +L+ + Sbjct: 25 GNTYTLRKQLGKGANGIVYLAE-TSDGH-VALKV--------SDDSLSITSEVNVLKSFS 74 Query: 243 SQFVVNLAYAYETKDALCL----------VLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292 V + ++ D + + + G L ++ + G Sbjct: 75 KAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPV-----LM 129 Query: 293 AEILCGLEDLHRENTVYRDLKPENILLD-DYGHIRISDLG 331 ++L L LH++ ++ DLKP+N+++ IR D+G Sbjct: 130 IQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >6BHC-A nrPDB Length = 438 Score = 71.5 bits (174), Expect = 1e-12, Method: Composition-based stats. Identities = 44/277 (15%), Positives = 94/277 (33%), Gaps = 55/277 (19%) Query: 212 YACKRLEKKRIKKRK------GESMALNEKQILEKVNS-----QFVVNLAYAYE----TK 256 YA K + K + ++ I + L + + Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQR 143 Query: 257 DALCLVLTIMNGGDLKFHIYNM-----GNPGFEEERALFYAAEILCGLEDLHRENTVYRD 311 + ++ + + + + +P E + ++ GLE L + + D Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCD 203 Query: 312 LKPENILLDDY---------------------GHIRISDLGLAVK---IPEGDLIRGRVG 347 L+ EN+LL Y + +S+ A + + + +++R + Sbjct: 204 LRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR 263 Query: 348 TVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407 +APE++ +Y D + G LIYEM+ +PF ++K E R L Sbjct: 264 ----LAPEIITATQY-KKCDEFQTGILIYEMLHLPNPF-DENPELKEREYTRADLP-RIP 316 Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKR 444 + +S + + LL + +R+ A + + Sbjct: 317 FRSPYSRGLQQLASCLLNPNPSERILI--SDAKGILQ 351 >4CI6-B nrPDB Length = 643 Score = 71.1 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 46/286 (16%), Positives = 90/286 (31%), Gaps = 49/286 (17%) Query: 206 RATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-----NSQFVVNLAY--AYETKDA 258 + ++ A +I++ E E + + + + N+ + Sbjct: 66 KDKQRLVA-------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNR 118 Query: 259 LC--LVLTIMNG----GDLKFHIYNMGNPGFE----EERALFYAAEILCGLEDLHRENTV 308 L++ ++G L+ + F A +L L + V Sbjct: 119 YYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIV 178 Query: 309 YRDLKPENILLDD-YGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV-LNNQRYGLSP 366 + D+KP N++ D G + DLGL + G+ +G T + APE+ + N Sbjct: 179 HNDIKPGNVVFDRASGEPVVIDLGLHSR--SGEQPKGF--TESFKAPELGVGNLGASEKS 234 Query: 367 DYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLET-----EEVYSHKFS-----EEA 416 D + ++ ++ G F E + + E E Y E A Sbjct: 235 DVF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETA 291 Query: 417 KS-ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGML 461 + +L A R + E + H F + A + Sbjct: 292 YTRFITDILGVSADSR-----PDSNEARLHEFLSDGTIDEESAKQI 332 >2JII-A nrPDB Length = 352 Score = 69.6 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 29/147 (19%), Positives = 53/147 (36%), Gaps = 11/147 (7%) Query: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTV 308 + + LVL + G L+ + E L A +L LE LH V Sbjct: 123 MGFGVHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 181 Query: 309 YRDLKPENILLD--DYGHIRISDLGLA-VKIPEGDLIRGRVGTV-------GYMAPEVLN 358 + ++ ENI +D D + ++ G A P G + G+ +++ ++ Sbjct: 182 HGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHK 241 Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPF 385 D LG + + + G P+ Sbjct: 242 GCGPSRRSDLQSLGYCMLKWLYGFLPW 268 >6M7Z-A nrPDB Length = 319 Score = 68.1 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 56/323 (17%), Positives = 106/323 (32%), Gaps = 58/323 (17%) Query: 173 WKWL----ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY---A---CKRLEKKRI 222 W W+ E + ++ + L G F + +T A + L Sbjct: 15 WSWMSYLKELPDIDESRNPILKRLLSGSF----LRRDGSTTVNVRVPARELVRLLSLTPE 70 Query: 223 KKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLV---LTIMNGGDLKFHIYNMG 279 ++R+G S + +L+ S + L K + L+ G +I++ Sbjct: 71 QQREGVSAKVRLINLLDPKYSVYEPYLYREILPKRSPLLLPSLGEY--RGAFLTYIFHPL 128 Query: 280 NPGF---------EEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDL 330 + G AA ++ L+ LH ++R ++ + + G + + Sbjct: 129 SKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLG-- 186 Query: 331 GLAVKIPEGDLIRGRVGTVGY-MAPEV---------LNNQRYGLSPDYWGLGCLIYEMIE 380 GL P G R VG G APE+ L R+ + D + LG Sbjct: 187 GLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAF----- 241 Query: 381 GQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAA 440 ++ + E V + K S + ++ ++ R Sbjct: 242 -RNLVQLLGNGNLGPEDRGAVRQDHLELLDKLS-------QKMIEEEPGNRPTI-----E 288 Query: 441 EVKRHPFFRNMNFKRLEAGMLDP 463 E+ + P F +NF+ +E G P Sbjct: 289 EIMKDPLFEGLNFEDIEEGKARP 311 >5GZ9-A nrPDB Length = 305 Score = 64.2 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 39/226 (17%), Positives = 69/226 (30%), Gaps = 40/226 (17%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231 +W E + RQ + +G+G V + + A R+ + + + Sbjct: 25 RWLSCEE---LRTEVRQLKRVGEGAVKRVFLSEWKE--HKVAL-----SRLTRLEMKEDF 74 Query: 232 LNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF----EEER 287 L+ Q+L+ + S+ VV L E ++ G L + + + Sbjct: 75 LHGLQMLKSLQSEHVVTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQH 132 Query: 288 ALFYAAEILCGLEDLHRENTVYRDLKPEN--------ILLDDYGHIRISDLGLAVKIPEG 339 L A E + + LH R + N LL I +DL + Sbjct: 133 RLQLAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHD 192 Query: 340 DLIRGRVGTVG----YMAPEVL------------NNQRYGLSPDYW 369 + + G ++APE L Y D W Sbjct: 193 SGVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >5GZA-A nrPDB Length = 290 Score = 63.0 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 39/225 (17%), Positives = 66/225 (29%), Gaps = 52/225 (23%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239 P ++ R+ +++G+G +V + + G+ A + + L+ +L Sbjct: 21 PEIRSGVRRVKLIGQGAVKKVYLSEWQ--GQKVAL-----SVLSSDQYADDFLHGLSMLR 73 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGF----EEERALFYAAEI 295 + S VV L E V G + + + L A + Sbjct: 74 ALQSSHVVTLVGVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDY 131 Query: 296 LCGLEDLHR--ENT--------VYRDLKPENILLDDYGHIRISDL---------GLAVKI 336 + L LH +++ L LL + +DL GL VK Sbjct: 132 VAFLAYLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRLLANDLDALPEVEKGGLGVKC 189 Query: 337 PEGDLIRGRVGTVGYMAPEVL------------NNQRYGLSPDYW 369 +L V APE L Y D W Sbjct: 190 GHHELTGDFV------APEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6G38-A nrPDB Length = 357 Score = 61.9 bits (149), Expect = 8e-10, Method: Composition-based stats. Identities = 33/204 (16%), Positives = 57/204 (27%), Gaps = 54/204 (26%) Query: 163 DSMFFDRFLQWKWLERQP----VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLE 218 ++++F + P + ++ +G+G FGEV T A K + Sbjct: 16 ENLYFQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIA 73 Query: 219 K-----------KRIKKRKGESMALNEKQILE-----------KVNSQFVVN------LA 250 K ++ E + E +L +NS V L Sbjct: 74 IEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLL 133 Query: 251 YAYET----------------KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 A++ D L +VL GG + M A + Sbjct: 134 KAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGG---IDLEQMRTKLSSLATAKSILHQ 190 Query: 295 ILCGLEDLH-RENTVYRDLKPENI 317 + L +RDL N+ Sbjct: 191 LTASLAVAEASLRFEHRDLHWGNV 214 >4CYJ-A nrPDB Length = 438 Score = 58.4 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 33/147 (22%), Positives = 55/147 (37%), Gaps = 18/147 (12%) Query: 197 FGE---VCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAY 253 FG V Q G+ YA +RLE R+ K + + +K+ + +V + + Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKD---WKKIKNASIVTIHEVF 121 Query: 254 ETKD----ALCLVLTIMNGG-DLKFHIYN-------MGNPGFEEERALFYAAEILCGLED 301 T++ +L L+ H + P E Y +I L+ Sbjct: 122 TTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKT 181 Query: 302 LHRENTVYRDLKPENILLDDYGHIRIS 328 +H R L+P I+L D IR+S Sbjct: 182 IHSNRLAARCLEPSKIILTDINRIRLS 208 >4AZW-A nrPDB Length = 471 Score = 57.3 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 26/134 (19%), Positives = 50/134 (37%), Gaps = 19/134 (14%) Query: 209 GKMYACKRLEKKR-------IKKRKGESMALNEKQILEK----VNSQFVVNLAYAYETKD 257 G+ Y CK + ++ + NE + L + ++ V+ E Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA---HGENAQ 315 Query: 258 ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENI 317 + LV+ + G L + EE +L L L ++ + D++P N+ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAG-----EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNV 370 Query: 318 LLDDYGHIRISDLG 331 ++D H R+ D G Sbjct: 371 MVDARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 56.1 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 26/134 (19%), Positives = 50/134 (37%), Gaps = 19/134 (14%) Query: 209 GKMYACKRLEKKR-------IKKRKGESMALNEKQILEK----VNSQFVVNLAYAYETKD 257 G+ Y CK + ++ + NE + L + ++ V+ E Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA---HGENAQ 315 Query: 258 ALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENI 317 + LV+ + G L + EE +L L L ++ + D++P N+ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAG-----EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNV 370 Query: 318 LLDDYGHIRISDLG 331 ++D H R+ D G Sbjct: 371 MVDARQHARLIDFG 384 >5VE6-A nrPDB Length = 492 Score = 55.3 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 29/71 (40%), Gaps = 5/71 (7%) Query: 254 ETKDALCLVLTIMNGGDLKFHIYN-----MGNPGFEEERALFYAAEILCGLEDLHRENTV 308 + +D + ++ + + + P E R F ++ GLE L + Sbjct: 171 QEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGII 230 Query: 309 YRDLKPENILL 319 +RDL EN+LL Sbjct: 231 HRDLCLENLLL 241 Score = 45.7 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 40/93 (43%), Gaps = 5/93 (5%) Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411 +APE+++ +Y D + G LIYE++ +PF RE R+ Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELLHQPNPF--EVRAQLRERDYRQEDLPPLPALSL 381 Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKR 444 +S + + +LL D +R+ E A V + Sbjct: 382 YSPGLQQLAHLLLEADPIKRIRIGE--AKRVLQ 412 >3ENH-A nrPDB Length = 540 Score = 53.0 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 29/173 (16%), Positives = 61/173 (35%), Gaps = 18/173 (10%) Query: 166 FFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEV----CACQVRATGKMYACKRLEKKR 221 + ++ W++ K ++ ++GKG ++ + K +R Sbjct: 319 YRTDMVEVNWIKEIKGKKRKIPEH-LIGKGAEADIKRDSYLDFDVIIKERVK-KGYRDER 376 Query: 222 IKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP 281 + + +S E + L V + D ++++ +NG K I + Sbjct: 377 LDENIRKSRTAREARYLALVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDN--- 433 Query: 282 GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAV 334 L A +I + LH+ + ++ DL N + D + I D GL Sbjct: 434 -------LDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGK 477 >4WWA-A nrPDB Length = 261 Score = 52.6 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 52/152 (34%), Gaps = 24/152 (15%) Query: 201 CACQVRATGKMYACK-----RLEKKRIKKRKGESMALNEKQILEKVN---SQFVVNLAYA 252 + + + + Y K R +I + + LNE ++L K+ V L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 253 YETKDALCLVL--TIMNGG----DLKFHIYNMGNPGFEE---ERALFYAAEILCGLEDLH 303 + L + GG +LK ++ + + +I GL LH Sbjct: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQI--GL--LH 153 Query: 304 RENTVYRDLKPENILLDDYG---HIRISDLGL 332 + + DL NI+L G + D GL Sbjct: 154 WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >3BYV-A nrPDB Length = 377 Score = 48.8 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 41/273 (15%), Positives = 88/273 (32%), Gaps = 53/273 (19%) Query: 202 ACQVRATGKMY--------------ACKRLEKKR--------IKKRKGESMALNEKQILE 239 + TG+ + A K+++++ IK +K + L + Sbjct: 91 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 150 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA---------LF 290 V + + + ++ ++ ++ G L Sbjct: 151 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 210 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG 350 +++ L LH V+ L+P +I+LD G + ++ G + +G + V + G Sbjct: 211 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLVRDGARVVSSV-SRG 267 Query: 351 YMAPEV------LNNQR-----YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDR 399 + PE+ ++ R S D W LG +IY + P E + R Sbjct: 268 FEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEWIFR 327 Query: 400 RVLETEEVYSHKFSEEAKSICKMLLTKDAKQRL 432 + +++ + L + RL Sbjct: 328 S--------CKNIPQPVRALLEGFLRYPKEDRL 352 >2W1Z-A nrPDB Length = 368 Score = 48.4 bits (114), Expect = 8e-06, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 95/305 (31%), Gaps = 67/305 (21%) Query: 183 KNTFRQYRVLGK--------------GGFGEVCACQVRATGKMY--------------AC 214 + +FR LG+ G + + TG+ A Sbjct: 44 EQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPSNAI 102 Query: 215 KRLEK--------KRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIM 266 K+L + + IK ++ L ++ V + + + ++ Sbjct: 103 KQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLSRFF 162 Query: 267 NGGDLKFHIYNMGNPGFEEERA---------LFYAAEILCGLEDLHRENTVYRDLKPENI 317 ++ +++ +G+ L +++ L V+ D + NI Sbjct: 163 LYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNI 222 Query: 318 LLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE-----VLNNQRY-----GLSPD 367 LLD G + ++ G + +G +G G+ PE +L +++ D Sbjct: 223 LLDQRGGVFLT--GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFD 279 Query: 368 YWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKD 427 W LG IY + P E+ + +E + +++ + L Sbjct: 280 TWTLGLAIYWIWCADLP--------NTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYS 331 Query: 428 AKQRL 432 + RL Sbjct: 332 KEDRL 336 >4CZY-B nrPDB Length = 429 Score = 47.6 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 48/144 (33%), Gaps = 23/144 (15%) Query: 201 CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYET----K 256 Q G+ +A +R+E R+ K E +K+ + +V + A+ T Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKE---WKKIINANIVTVHEAFTTEFFGD 117 Query: 257 DALCLVLTIMNGGDLKFHIYNMGNP------------GFEEERALFYAAEILCGLEDLHR 304 +L V L +Y+ P E Y +I L +H Sbjct: 118 SSLIFVYDFHP---LSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHN 174 Query: 305 ENTVYRDLKPENILLDDYGHIRIS 328 R L+ I + + IR++ Sbjct: 175 AKLAARCLELSKI-IWENNRIRLA 197 >4BWP-A nrPDB Length = 448 Score = 47.6 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 24/140 (17%), Positives = 40/140 (28%), Gaps = 37/140 (26%) Query: 201 CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETK---- 256 TG Y +R+ R++ K + ++ +K+ VV L + TK Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTK----CMTLVEMWKKLQHTNVVQLREVFTTKAFGD 122 Query: 257 DALCLVLTIMNGGDL-------------------------KFHIYNMGN----PGFEEER 287 ++L LV G H NM P E Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 288 ALFYAAEILCGLEDLHRENT 307 ++ GL+ +H Sbjct: 183 IWSIIMQLTAGLKAIHHAGL 202 >1TQM-A nrPDB Length = 282 Score = 45.7 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 35/169 (20%), Positives = 64/169 (37%), Gaps = 36/169 (21%) Query: 188 QYRVLGKGGFGEVCACQVRATGKMYACK--RLEKKRIKKRKGES-------------MAL 232 +++G+G V C G+ K ++ KK K + A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152 Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE---EERAL 289 NE + L+K+ V + A+E +++ +++ +L + + EE A Sbjct: 153 NEFRALQKLQGLAVPKVY-AWEGN---AVLMELIDAKELYRVRVENPDEVLDMILEEVAK 208 Query: 290 FYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPE 338 FY H V+ DL N+L+ + G I I D +V++ E Sbjct: 209 FY-----------H-RGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGE 244 >3DZO-A nrPDB Length = 413 Score = 44.9 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 39/272 (14%), Positives = 83/272 (30%), Gaps = 52/272 (19%) Query: 202 ACQVRATGKMY--------------ACKRLEKKR--------IKKRKGESMALNEKQILE 239 + TG+ + A K+++++ IK +K + L + Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 155 Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA---------LF 290 V + + + ++ ++ ++ G L Sbjct: 156 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 215 Query: 291 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG 350 +++ L LH V+ L+P +I+LD G + ++ G + +G +G G Sbjct: 216 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLVRDGASAVSPIG-RG 272 Query: 351 YMAPEV----------LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400 + PE + + D W LG IY + P E + R Sbjct: 273 FAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRS 332 Query: 401 VLETEEVYSHKFSEEAKSICKMLLTKDAKQRL 432 + +++ + L + RL Sbjct: 333 --------CKNIPQPVRALLEGFLRYPKEDRL 356 >2I59-A nrPDB Length = 138 Score = 44.9 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 27/122 (22%), Positives = 58/122 (47%), Gaps = 5/122 (4%) Query: 58 DKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDE-KLGEKGKEIMTKYLTPKSPV 116 + P G FR+F + + E + F + +++ D+ ++ EK KEI +L+ K+ Sbjct: 19 LEDPEGVKRFREFLK-KEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKA-- 75 Query: 117 FIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWL 176 +QV + S+ EK+L++P +F + ++ + + +L S F + + + Sbjct: 76 -SSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEE 134 Query: 177 ER 178 E Sbjct: 135 EE 136 >2IHB-B nrPDB Length = 153 Score = 44.6 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 26/116 (22%), Positives = 56/116 (48%), Gaps = 5/116 (4%) Query: 58 DKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDE-KLGEKGKEIMTKYLTPKSPV 116 + P G FR+F + + E + F + +++ D+ ++ EK KEI +L+ K+ Sbjct: 39 LEDPEGVKRFREFLK-KEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKA-- 95 Query: 117 FIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQ 172 +QV + S+ EK+L++P +F + ++ + + +L S F + + Sbjct: 96 -SSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKR 150 >3Q60-A nrPDB Length = 371 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 29/152 (19%), Positives = 50/152 (32%), Gaps = 12/152 (7%) Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN--N 359 L + V+ P+N+ + G + + D ++ G V Y E LN Sbjct: 210 LQSKGLVHGHFTPDNLFIMPDGRLMLGD--VSALWKVGTRGPASSVPVTYAPREFLNAST 267 Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS------HKFS 413 + + + W LG IY + PF G + R L S Sbjct: 268 ATFTHALNAWQLGLSIYRVWCLFLPF-GLVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLP 326 Query: 414 EEAKSICKMLLTKDAKQR-LGCQEEGAAEVKR 444 + K++ L D ++R L + E + Sbjct: 327 DFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQ 358 >2JNU-A nrPDB Length = 154 Score = 38.4 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 16/115 (13%), Positives = 51/115 (44%), Gaps = 7/115 (6%) Query: 58 DKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYE---VTPDEKLGEKGKEIMTKYLTPKS 114 + P+G F +F + + + F + ++ + ++L ++ + I ++L+ ++ Sbjct: 19 LQDPLGLAYFTEFLK-KEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQA 77 Query: 115 PVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDR 169 + V D + E++L +P ++F A + ++ + + ++ S + Sbjct: 78 L---SPVNIDRQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRE 129 >2BV1-A nrPDB Length = 145 Score = 38.4 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 20/135 (14%), Positives = 53/135 (39%), Gaps = 10/135 (7%) Query: 38 HISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEK 97 ++ +++++ G+ +F F ++ E I+F + +Y+ T + Sbjct: 15 SAAEVMQWSQSLEK-----LLANQTGQNVFGSFLKS-EFSEENIEFWLACEDYKKTESDL 68 Query: 98 LGEKGKEIMTKYLTPKSPVFIAQVGQDL-VSQTEEKLLQKPCKELFSACAQSVHEYLRGE 156 L K +EI ++ + Q+ D ++ K ++ P F + ++ + + Sbjct: 69 LPCKAEEIYKAFVHSDAA---KQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKD 125 Query: 157 PFHEYLDSMFFDRFL 171 + +L S + L Sbjct: 126 SYPRFLKSDIYLNLL 140 >4BVU-A nrPDB Length = 211 Score = 37.6 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 49/148 (33%), Gaps = 23/148 (15%) Query: 188 QYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 +++G+G E+ ++ K+ + + + MA E + Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESE----------- 89 Query: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI----LCGLEDLH 303 L A+ D +V+ GGD+ + + + I L + L+ Sbjct: 90 -LFNAFY-GDEASVVIQY--GGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLN 145 Query: 304 RENTVYRDLKPENILLDDYGH-IRISDL 330 + ++ DL N+L D + D Sbjct: 146 ELSIIHYDLNTGNMLYDKESESLFPIDF 173 >6FAI-l nrPDB Length = 425 Score = 37.6 bits (86), Expect = 0.016, Method: Composition-based stats. Identities = 20/186 (10%), Positives = 54/186 (29%), Gaps = 39/186 (20%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKRL------------EKKRIKKRKGESMAL 232 + +G G ++ + G K + +KK + + Sbjct: 94 VYSVGNTIGVGKESDIYKVSDK-NGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWM 152 Query: 233 --------NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE 284 E Q + + S+ + ++ + +V+ ++ G ++ + P Sbjct: 153 HLSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-VVMELIEGYPMRRLRKHKNIPKLY 210 Query: 285 EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDD------YGHIRISDL--GLAVKI 336 + F L ++ D NI++ D + D ++++ Sbjct: 211 SDLMCFIVD--------LANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQH 262 Query: 337 PEGDLI 342 + D Sbjct: 263 QDADYY 268 >6FDN-A nrPDB Length = 320 Score = 36.5 bits (83), Expect = 0.032, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 33/76 (43%), Gaps = 8/76 (10%) Query: 255 TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKP 314 + +V+ ++NG L I+++ +P + A+ ++ ++ D Sbjct: 180 DYNRHAVVMELINGYPLCQ-IHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNE 231 Query: 315 ENILLDDYGHIRISDL 330 N++LD+ HI + D Sbjct: 232 FNLILDESDHITMIDF 247 >6G18-v nrPDB Length = 552 Score = 36.5 bits (83), Expect = 0.033, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 33/76 (43%), Gaps = 8/76 (10%) Query: 255 TKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKP 314 + +V+ ++NG L I+++ +P + A+ ++ ++ D Sbjct: 180 DYNRHAVVMELINGYPLCQ-IHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNE 231 Query: 315 ENILLDDYGHIRISDL 330 N++LD+ HI + D Sbjct: 232 FNLILDESDHITMIDF 247 >5YK0-A nrPDB Length = 452 Score = 35.3 bits (80), Expect = 0.071, Method: Composition-based stats. Identities = 28/179 (15%), Positives = 52/179 (29%), Gaps = 42/179 (23%) Query: 198 GEVCACQVRATGKMYACKRLEKKRIKK-RKGESMALNEKQILEKV----NSQFVVN---- 248 G+V + G+ A K + R +L+++ + Q VV+ Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 249 -----------------LAYAYETKDAL-----------CLVLTIMNGGDLKFHIYNMGN 280 A AY ++ + G + I + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRH--G 262 Query: 281 PGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG 339 + + AE+ + R ++ D P N +L G + I D G +P G Sbjct: 263 TTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFGAVAPMPGG 319 >1DK8-A nrPDB Length = 147 Score = 33.0 bits (74), Expect = 0.39, Method: Composition-based stats. Identities = 21/125 (16%), Positives = 46/125 (36%), Gaps = 8/125 (6%) Query: 54 CSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEV-----TPDEKLGEKGKEIMTK 108 SL D Q G LFR F + + G + F + + + +EK + + I K Sbjct: 17 HSLLDDQD-GISLFRTFLK-QEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRK 74 Query: 109 YLTPKSPVFIAQVGQDLVSQTEEKLLQKPC-KELFSACAQSVHEYLRGEPFHEYLDSMFF 167 Y+ + + Q S + ++++ +F + + + +L S + Sbjct: 75 YILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIY 134 Query: 168 DRFLQ 172 + + Sbjct: 135 LEYTR 139 >1EMU-A nrPDB Length = 132 Score = 32.6 bits (73), Expect = 0.54, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 45/123 (36%), Gaps = 8/123 (6%) Query: 54 CSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEV-----TPDEKLGEKGKEIMTK 108 SL D Q G LFR F + + G + F + + + +EK + + I K Sbjct: 11 HSLLDDQD-GISLFRTFLK-QEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRK 68 Query: 109 YLTPKSPVFIAQVGQDLVSQTEEKLLQKPC-KELFSACAQSVHEYLRGEPFHEYLDSMFF 167 Y+ + + Q S + ++++ +F + + + +L S + Sbjct: 69 YILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIY 128 Query: 168 DRF 170 + Sbjct: 129 LEY 131 >2EG4-A nrPDB Length = 230 Score = 32.2 bits (72), Expect = 0.63, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 20/52 (38%) Query: 438 GAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGV 489 A E RHP ++ G + PP P + +E F + +G+ Sbjct: 124 TADEAARHPLLLDVRSPEEFQGKVHPPCCPRGGRIPGSKNAPLELFLSPEGL 175 >2QG7-A nrPDB Length = 458 Score = 32.2 bits (72), Expect = 0.67, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 34/106 (32%), Gaps = 23/106 (21%) Query: 214 CKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDL-K 272 K L + K EK+I + ++ + Y + T + M+G L + Sbjct: 134 AKYLIRLYGPKTDEIINREREKKISCILYNKNIAKKIYVFFTNGR---IEEFMDGYALSR 190 Query: 273 FHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKP-ENI 317 I N I L+ LH D+K EN+ Sbjct: 191 EDIKNPKFQKL-----------IAKNLKLLH-------DIKLNENL 218 >6DFL-A nrPDB Length = 259 Score = 31.8 bits (71), Expect = 0.76, Method: Composition-based stats. Identities = 17/127 (13%), Positives = 39/127 (30%), Gaps = 16/127 (12%) Query: 193 GKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL--- 249 G+G F ++ G+ + K + + A E Q + +++ V + Sbjct: 45 GRGYFVKIHRGI--GWGE------IAKNLLTAKLPVLGARQEWQAIRRLHEAGVATMTAV 96 Query: 250 ----AYAYETKDALCLVLT-IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304 + + +V + DL+ + + + D+HR Sbjct: 97 AYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHR 156 Query: 305 ENTVYRD 311 +RD Sbjct: 157 AGVNHRD 163 >6JCV-A nrPDB Length = 333 Score = 31.5 bits (70), Expect = 0.98, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 47/132 (35%), Gaps = 24/132 (18%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK--------------- 235 V+G G G V A +R G ++ K + K E + E Sbjct: 20 VIGYGNQGRVQATIMRENGLNVIVGNVKDKYYELAKKEGFEVYEIDEAVRRSDVALLLIP 79 Query: 236 -QILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAE 294 +++++V + + + K VL +G ++ F + P + + Sbjct: 80 DEVMKEVYEKKIAP---VLQGKKEF--VLDFASGYNVAFGLI---RPPKSVDTIMVAPRM 131 Query: 295 ILCGLEDLHREN 306 + G+ DLH++ Sbjct: 132 VGEGIMDLHKQG 143 >6EF6-A nrPDB Length = 354 Score = 31.5 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 13/28 (46%), Gaps = 3/28 (10%) Query: 306 NTVYRDLKPENILLDD---YGHIRISDL 330 ++ DL+ N+L+D I + D Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >3LV4-A nrPDB Length = 456 Score = 31.1 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 15/45 (33%), Gaps = 2/45 (4%) Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286 VV+ ++ L +V +GG F + GF Sbjct: 142 KHPNVVDPHTFFDQNGKLWMVYGSYSGG--IFILEMDKKTGFPLP 184 >2X8T-A nrPDB Length = 471 Score = 31.1 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 15/45 (33%), Gaps = 2/45 (4%) Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEE 286 VV+ ++ L +V +GG F + GF Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGG--IFILEMNPKTGFPLP 207 >5YSW-A nrPDB Length = 441 Score = 30.7 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 28/144 (19%), Positives = 47/144 (32%), Gaps = 37/144 (25%) Query: 377 EMIEGQSPFRGRKEKVKREE---VDRRVLETEEVYSHKFS--EEAKSICKMLLTKDAKQR 431 E + + PF V E V R L + + S EEA+++ D R Sbjct: 43 EFVRREDPFHVPPALVAVSERGPVARATLAAGDPFW-LVSGYEEARAVLS-----DP--R 94 Query: 432 LGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNL 491 + HP+F+ ++ P+ R D F +N+ Sbjct: 95 FSSDR-----FQYHPWFKELS--------------PEFRERLRDDKARAGSF-----INM 130 Query: 492 DHTDDDFYSKFSTGSVSIPWQNEM 515 D + Y K TG ++ E+ Sbjct: 131 DPPEHTRYRKLLTGQFTVRRIREL 154 >5B5N-L nrPDB Length = 281 Score = 30.3 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 17/35 (48%) Query: 229 SMALNEKQILEKVNSQFVVNLAYAYETKDALCLVL 263 S AL E +I K+ F V A+++ L LV Sbjct: 108 SWALREVEICRKLGIGFHVPFAFSFAIGAYLVLVF 142 >5H8W-A nrPDB Length = 597 Score = 29.5 bits (65), Expect = 4.4, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 31/77 (40%), Gaps = 1/77 (1%) Query: 67 FRQFCETRPGLECYIQFLDSV-AEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDL 125 F++ E P YI + D V ++Y+ +++L I L K + L Sbjct: 383 FKKIGEIFPPENRYIAYYDGVSSKYDTLDEKELDRMATVIEDIILKVKKNTIVYFPSYSL 442 Query: 126 VSQTEEKLLQKPCKELF 142 + + E ++ + KE Sbjct: 443 MDRVENRVSFEHMKEYR 459 >4ESA-B nrPDB Length = 146 Score = 29.1 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 10/50 (20%), Positives = 15/50 (30%), Gaps = 5/50 (10%) Query: 195 GGFGEVCACQVRATGKMYA---CKRLE--KKRIKKRKGESMALNEKQILE 239 G FG + + + A K L + +K E IL Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILH 92 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.145 0.422 Lambda K H 0.267 0.0447 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,106,707 Number of Sequences: 36641 Number of extensions: 1116549 Number of successful extensions: 6856 Number of sequences better than 10.0: 516 Number of HSP's better than 10.0 without gapping: 912 Number of HSP's successfully gapped in prelim test: 69 Number of HSP's that attempted gapping in prelim test: 2871 Number of HSP's gapped (non-prelim): 1099 length of query: 590 length of database: 10,336,785 effective HSP length: 103 effective length of query: 487 effective length of database: 6,562,762 effective search space: 3196065094 effective search space used: 3196065094 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (20.9 bits) S2: 62 (28.4 bits)