BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P34913 (555 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4Y2Y-A nrPDB 1154 0.0 1CR6-A nrPDB 879 0.0 5Y6Y-B nrPDB 188 5e-48 2E3J-A nrPDB 171 5e-43 4NZZ-A nrPDB 110 2e-24 4IQ4-A nrPDB 79 5e-15 4NVR-A nrPDB 78 1e-14 1BRO-A nrPDB 76 4e-14 5UXZ-A nrPDB 75 6e-14 2EDA-A nrPDB 72 9e-13 3FOB-A nrPDB 70 3e-12 1HKH-A nrPDB 70 3e-12 1A8S-A nrPDB 64 2e-10 2B0C-A nrPDB 63 3e-10 3HEA-A nrPDB 62 5e-10 3WMR-A nrPDB 60 2e-09 3OM8-A nrPDB 60 2e-09 5EGN-A nrPDB 59 5e-09 4UHD-A nrPDB 59 6e-09 2O2H-A nrPDB 58 1e-08 2WUG-A nrPDB 57 3e-08 1A88-A nrPDB 57 3e-08 3HSS-A nrPDB 56 4e-08 3A2L-A nrPDB 55 9e-08 4DGQ-A nrPDB 55 1e-07 2XUA-A nrPDB 54 1e-07 1A8Q-A nrPDB 51 1e-06 1U2E-A nrPDB 50 2e-06 3V1K-A nrPDB 50 3e-06 2PSJ-A nrPDB 49 5e-06 3NWO-A nrPDB 49 6e-06 3KXP-A nrPDB 48 1e-05 3KBB-A nrPDB 47 2e-05 4G5X-A nrPDB 47 2e-05 4HTA-A nrPDB 45 1e-04 4JB3-A nrPDB 44 2e-04 4CCW-A nrPDB 44 2e-04 3V48-A nrPDB 43 4e-04 4RNC-A nrPDB 42 6e-04 1DWO-A nrPDB 41 0.001 2WJ4-A nrPDB 41 0.002 2XMZ-A nrPDB 40 0.003 4NMW-A nrPDB 40 0.004 4FBL-A nrPDB 39 0.004 6AP7-A nrPDB 39 0.005 6EIC-C nrPDB 39 0.005 3BF8-A nrPDB 39 0.005 4QLA-A nrPDB 39 0.005 4IH4-A nrPDB 39 0.008 1IMJ-A nrPDB 39 0.008 1OIL-A nrPDB 38 0.009 5YHP-A nrPDB 38 0.011 5XKS-A nrPDB 38 0.015 1AZW-A nrPDB 37 0.015 6COB-A nrPDB 37 0.016 3P2M-A nrPDB 37 0.022 1Y7H-A nrPDB 37 0.024 5OLW-A nrPDB 37 0.024 1TAH-B nrPDB 37 0.025 1SCK-A nrPDB 35 0.072 3RLI-A nrPDB 35 0.085 2YYS-A nrPDB 35 0.11 4CCY-A nrPDB 35 0.12 1QTR-A nrPDB 35 0.12 2WFL-A nrPDB 34 0.17 4GW3-A nrPDB 34 0.20 3O4I-A nrPDB 33 0.28 2YY6-A nrPDB 33 0.42 3FCY-A nrPDB 33 0.46 1M33-A nrPDB 32 0.92 6HIX-BG nrPDB 32 0.96 4HXF-B nrPDB 31 1.6 2ZIG-A nrPDB 30 3.7 1TE2-A nrPDB 30 3.7 4G9B-A nrPDB 30 4.0 5JRK-A nrPDB 29 4.2 3BMB-A nrPDB 29 5.9 1R3D-A nrPDB 29 6.1 3CC1-A nrPDB 29 6.6 6CL4-A nrPDB 29 6.8 2L0Q-A nrPDB 28 7.1 4KNV-A nrPDB 28 8.1 2GFH-A nrPDB 28 8.1 3HLT-A nrPDB 28 9.2 >4Y2Y-A nrPDB Length = 561 Score = 1154 bits (2986), Expect = 0.0, Method: Compositional matrix adjust. Identities = 555/555 (100%), Positives = 555/555 (100%) Query: 1 MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL 60 MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL Sbjct: 1 MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL 60 Query: 61 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA 120 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA Sbjct: 61 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA 120 Query: 121 ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV 180 ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV Sbjct: 121 ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV 180 Query: 181 VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG 240 VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG Sbjct: 181 VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG 240 Query: 241 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS Sbjct: 241 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 Query: 301 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT Sbjct: 301 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 Query: 361 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH 420 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH Sbjct: 361 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH 420 Query: 421 KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL 480 KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL Sbjct: 421 KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL 480 Query: 481 GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK Sbjct: 481 GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 Query: 541 WLDSDARNPPVVSKM 555 WLDSDARNPPVVSKM Sbjct: 541 WLDSDARNPPVVSKM 555 >1CR6-A nrPDB Length = 554 Score = 879 bits (2272), Expect = 0.0, Method: Compositional matrix adjust. Identities = 406/556 (73%), Positives = 482/556 (86%), Gaps = 3/556 (0%) Query: 1 MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL 60 M LR A FDLDGVLALP++ G R+EEALALPR L A+Q PEG T +LMKG+IT Sbjct: 1 MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITF 60 Query: 61 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA 120 SQW+PLM+E+ RK S+ LP+NFSI +IF +A++AR INRPMLQAA+ L+KKGFTT Sbjct: 61 SQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTC 120 Query: 121 ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV 180 I+TN WLDD +RD LAQ+MCEL HFDFLIESCQVGM+KPEPQIY FLLDTLKA P+EV Sbjct: 121 IVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEV 180 Query: 181 VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG 240 VFLDD G+NLKPARD+GMVTILV +T +AL+ELEKVTG Q APLP CNP+D+SHG Sbjct: 181 VFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQF--PEAPLPVPCNPNDVSHG 238 Query: 241 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 YVTVKP +RLHFVE+GSGPA+CLCHGFPESW+SWRYQIPALAQAG+RVLA+DMKGYG+SS Sbjct: 239 YVTVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSS 298 Query: 301 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 +PPEIEEY ME+LCKEMVTFLDKLG+ QAVFIGHDW G++VW MALFYPERVRAVASLNT Sbjct: 299 SPPEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNT 358 Query: 361 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDES-VLSM 419 PF+P +P++SP++ I++ PVF+YQLYFQEPGVAEAELE+N+SRTFKS FRASDE+ +++ Sbjct: 359 PFMPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAV 418 Query: 420 HKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKS 479 HK E GG+ VN+PE+P+LS++ TEEEI+FY+QQFKK+GFRGPLNWYRN ERNWKW+CK Sbjct: 419 HKATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKG 478 Query: 480 LGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILI 539 LGRKIL+PALMVTAEKD VL P+MS++ME WIP LKRGHIEDCGHWTQ++KPTEVNQILI Sbjct: 479 LGRKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILI 538 Query: 540 KWLDSDARNPPVVSKM 555 KWL ++ +NP V SK+ Sbjct: 539 KWLQTEVQNPSVTSKI 554 >5Y6Y-B nrPDB Length = 326 Score = 188 bits (478), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 99/307 (32%), Positives = 171/307 (55%), Gaps = 17/307 (5%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 +++H E G GP V HGFPE WYSWR+QI AL+ GYR +A D++GYG++ AP I Sbjct: 14 IKMHVAEKGEGPVVLFLHGFPELWYSWRHQILALSSRGYRAVAPDLRGYGDTEAPVSISS 73 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANP 367 Y + +++ +D LG+ Q + HDWG ++ WY+ F+P+RV+A L+ P + +P Sbjct: 74 YTGFHIVGDLIALIDLLGVDQVFLVAHDWGAIIGWYLCTFHPDRVKAYVCLSVPLLHRDP 133 Query: 368 NMSPLESIKANPVFDYQL-YFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAG 426 N+ +++++A DY + FQ+PG EA++ + + + + + E G Sbjct: 134 NIRTVDAMRAMYGDDYYICRFQKPGEMEAQMAEVGTEYVLKNILTTRKPGPPIFPKGEYG 193 Query: 427 GLFVNSPEEP-SLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKIL 485 F +P+ P SL +T++++ +YV +++K+GF GPLN+YRNM NW+ G KI Sbjct: 194 TGF--NPDMPNSLPSWLTQDDLAYYVSKYEKTGFTGPLNYYRNMNLNWELTAPWSGGKIQ 251 Query: 486 IPALMVTAEKDFVLVPQMSQHMEDWI---------PHLKRGHIE-DCGHWTQMDKPTEVN 535 +P +T E D V S +M+++I P+L+ ++ + H+ + E+N Sbjct: 252 VPVKFITGELDNVYT---SLNMKEYIHGGGFKQDVPNLEEVIVQKNVAHFNNQEAAEEIN 308 Query: 536 QILIKWL 542 + ++ Sbjct: 309 NHIYDFI 315 >2E3J-A nrPDB Length = 356 Score = 171 bits (434), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 105/326 (32%), Positives = 160/326 (49%), Gaps = 42/326 (12%) Query: 258 GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEM 317 GP V L HGFPESWYSWR+QIPALA AGYRV+A+D +GYG SS + Y ++ L ++ Sbjct: 27 GPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSKYRVQKAYRIKELVGDV 86 Query: 318 VTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPF-------IPAN---- 366 V LD G QA +GHDWG + W A +P+R V ++ PF +P + Sbjct: 87 VGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVPFAGRGVIGLPGSPFGE 146 Query: 367 --PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSL-FRASDESVLSMHKVC 423 P+ LE V+ YQ YF E+E++L L + S E +++ K Sbjct: 147 RRPSDYHLELAGPGRVW-YQDYFAVQDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKAA 205 Query: 424 EAGGLFVNSPEEPSLSRM------------------------VTEEEIQFYVQQFKKSGF 459 G+ + S + + R TE ++ FY +F++SGF Sbjct: 206 VDAGVDLESMDPIDVIRAGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGF 265 Query: 460 RGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLV--PQMSQHMEDWIPHLKRG 517 GPL++Y N++ +W G+ + PAL + + D + Q + + +P+ + Sbjct: 266 GGPLSFYHNIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYRGT 325 Query: 518 H-IEDCGHWTQMDKPTEVNQILIKWL 542 H I D GHW Q + P E N++L+ +L Sbjct: 326 HMIADVGHWIQQEAPEETNRLLLDFL 351 >4NZZ-A nrPDB Length = 320 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 76/317 (23%), Positives = 142/317 (44%), Gaps = 41/317 (12%) Query: 237 MSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGY 296 MS Y+ V V LH++ G G + HGFP+ + WR+QI + + +A+D++GY Sbjct: 34 MSKQYINVNG-VNLHYISKGQGELMLFLHGFPDFSHIWRHQIDEFSND-FHTVALDLRGY 91 Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVA 356 S P +E Y ++VL +++ ++ LG S + HDWG + W A YPE V+ + Sbjct: 92 NLSEKPSGLESYEIDVLVEDIRQVIEGLGYSSCTLVVHDWGAGIGWTFAYRYPEYVQKLI 151 Query: 357 SLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESV 416 + N P P + +Y +FQ+ V + N S K + Sbjct: 152 AFNGPH-PYTFMRELRTNKNQQKASEYMKWFQKQEVQDYMERDNFSGLRKLVI------- 203 Query: 417 LSMHKVCEAGGLFVNSPEEPSLSR-MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKW 475 +P + + +T +++Q Y+ ++ L++YRN++ + Sbjct: 204 ------------------DPGVKKGYLTADDVQAYMNSWENGSVLSMLSYYRNLK---IF 242 Query: 476 ACKSLGRKIL---------IPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWT 526 + L RK L IP ++ +D +P+ +E+++P++ + + H Sbjct: 243 TEEDLRRKSLFPLEEEVLNIPVQIIWGNQDPTFMPENLDGIEEYVPNISVHRLAEASHAP 302 Query: 527 QMDKPTEVNQILIKWLD 543 Q +KP EVN ++ +L+ Sbjct: 303 QHEKPQEVNNVMWNFLN 319 >4IQ4-A nrPDB Length = 456 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 44/119 (36%), Positives = 67/119 (56%), Gaps = 5/119 (4%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 + L++ + G+G V L HGFP S +SW Q AL AGYRV+ D +G+G+SS P + Sbjct: 14 IDLYYEDHGTGTPVVLIHGFPLSGHSWERQSAALLDAGYRVITYDRRGFGQSSQPTTGYD 73 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWG-GMLVWYMALFYPERVRAVASLNT--PFI 363 Y + ++ T L+ L L AV +G G G + Y++ + R+ AVA L + PF+ Sbjct: 74 Y--DTFAADLNTVLETLDLQDAVLVGFSMGTGEVARYVSSYGTARIAAVAFLASLEPFL 130 >4NVR-A nrPDB Length = 307 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 39/100 (39%), Positives = 58/100 (58%), Gaps = 4/100 (4%) Query: 256 GSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAP---PEIEEYCMEV 312 GSG + L HG P++ +WR P LAQ + V+ D++GYG+S P P Y Sbjct: 38 GSGSPLVLLHGHPQNHTTWRKVAPTLAQ-NHTVILPDLRGYGDSDKPTSDPAHRTYSKRT 96 Query: 313 LCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERV 352 + +++V +D LG S+ F+GHD GG + +AL YP+RV Sbjct: 97 MAQDIVMLMDALGFSRFAFVGHDRGGRVGHRLALDYPDRV 136 >1BRO-A nrPDB Length = 277 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 43/119 (36%), Positives = 65/119 (54%), Gaps = 5/119 (4%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 + L++ + G+G V L HGFP S +SW Q AL AGYRV+ D +G+G+SS P Sbjct: 13 IDLYYEDHGTGQPVVLIHGFPLSGHSWERQSAALLDAGYRVITYDRRGFGQSSQP--TTG 70 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWG-GMLVWYMALFYPERVRAVASLNT--PFI 363 Y + ++ T L+ L L AV +G G G + Y++ + R+ VA L + PF+ Sbjct: 71 YDYDTFAADLNTVLETLDLQDAVLVGFSMGTGEVARYVSSYGTARIAKVAFLASLEPFL 129 >5UXZ-A nrPDB Length = 307 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 77/312 (24%), Positives = 126/312 (40%), Gaps = 56/312 (17%) Query: 249 RLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIE 306 R+H+V++G G V HG P S Y WR IP +A +R +A D+ G G+S P Sbjct: 18 RMHYVDVGPRDGTPVLFLHGNPTSSYVWRNIIPHVAPT-HRCIAPDLIGMGKSDKPDL-- 74 Query: 307 EYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPAN 366 Y + + M F++ LGL + V + HDWG L ++ A PERV+ +A Sbjct: 75 GYFFDDHVRFMDAFIEALGLEEVVLVIHDWGSALGFHWAKRNPERVKGIAF--------- 125 Query: 367 PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAG 426 +E I+ P +D E + TF++ FR +D K+ Sbjct: 126 -----MEFIRPIPTWD-------------EWPEFARETFQA-FRTTDVG----RKLIIDQ 162 Query: 427 GLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRN--------------MERN 472 +F+ + R +TE E+ Y + F R PL + N +E Sbjct: 163 NVFIEGTLPMGVVRPLTEVEMDHYREPFLNPVDREPLWRFPNELPIAGEPANIVALVEEY 222 Query: 473 WKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPT 532 W +S +P L+ ++ P + + +P+ K I + Q D P Sbjct: 223 MDWLHQS-----PVPKLLFWGTPGVLIPPAEAARLAKSLPNCKAVDIGPGLNLLQEDNPD 277 Query: 533 EVNQILIKWLDS 544 + + +WL + Sbjct: 278 LIGSEIARWLST 289 >2EDA-A nrPDB Length = 310 Score = 71.6 bits (174), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 44/135 (32%), Positives = 68/135 (50%), Gaps = 7/135 (5%) Query: 229 PTSCNPSDMSHGYVTVKPRVRLHFVELGSGPA--VCLC-HGFPESWYSWRYQIPALAQAG 285 P S N D GY P +R H+++ G+ A V LC HG P Y +R IP A++G Sbjct: 19 PFSPNYLDDLPGY----PGLRAHYLDEGNSDAEDVFLCLHGEPTWSYLYRKMIPVFAESG 74 Query: 286 YRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMA 345 RV+A D G+G+S P + E+Y E ++ +++L L + DWGG L + Sbjct: 75 ARVIAPDFFGFGKSDKPVDEEDYTFEFHRNFLLALIERLDLRNITLVVQDWGGFLGLTLP 134 Query: 346 LFYPERVRAVASLNT 360 + P R + + +N Sbjct: 135 MADPSRFKRLIIMNA 149 >3FOB-A nrPDB Length = 281 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 39/109 (35%), Positives = 63/109 (57%), Gaps = 3/109 (2%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 + +++ + G+G V L HG+P S SW YQ+PAL +AGYRV+ D +G+G+SS P E E Sbjct: 17 IEIYYEDHGTGKPVVLIHGWPLSGRSWEYQVPALVEAGYRVITYDRRGFGKSSQPWEGYE 76 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVW-YMALFYPERVRAV 355 Y + ++ L++L L +G GG V Y++ + +R+ V Sbjct: 77 Y--DTFTSDLHQLLEQLELQNVTLVGFSMGGGEVARYISTYGTDRIEKV 123 >1HKH-A nrPDB Length = 279 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 49/144 (34%), Positives = 70/144 (48%), Gaps = 12/144 (8%) Query: 240 GYVTVKPR----VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKG 295 GY+TV + L++ + GSG V L HG+P +SW Q L GYRV+ D +G Sbjct: 1 GYITVGNENSTPIELYYEDQGSGQPVVLIHGYPLDGHSWERQTRELLAQGYRVITYDRRG 60 Query: 296 YGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWG-GMLVWYMALFYPERVRA 354 +G SS +Y + ++ T L+ L L V +G G G L Y+A + ERV Sbjct: 61 FGGSSKVNTGYDY--DTFAADLHTVLETLDLRDVVLVGFSMGTGELARYVARYGHERVAK 118 Query: 355 VASLNT--PFI---PANPNMSPLE 373 +A L + PF+ NP P E Sbjct: 119 LAFLASLEPFLVQRDDNPEGVPQE 142 >1A8S-A nrPDB Length = 273 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/173 (30%), Positives = 80/173 (46%), Gaps = 25/173 (14%) Query: 243 TVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAP 302 T + ++++ + GSG + HG+P + SW Q+ LA GYRV+A D +G+G SS P Sbjct: 4 TTRDGTQIYYKDWGSGQPIVFSHGWPLNADSWESQMIFLAAQGYRVIAHDRRGHGRSSQP 63 Query: 303 PEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHD-WGGMLVWYMALFYPERVRAVASLNTP 361 + M+ ++ ++ L L AV G GG + Y+ RV A A L + Sbjct: 64 WSGND--MDTYADDLAQLIEHLDLRDAVLFGFSTGGGEVARYIGRHGTARV-AKAGLISA 120 Query: 362 FIP------ANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSL 408 P ANP P+E VFD G+ +A L + S+ +K L Sbjct: 121 VPPLMLKTEANPGGLPME------VFD--------GIRQASLA-DRSQLYKDL 158 >2B0C-A nrPDB Length = 206 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 96/212 (45%), Gaps = 20/212 (9%) Query: 7 VFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPL 66 +FDL V+ VLG + +P L +F G A + +GEI+ + Sbjct: 11 IFDLGNVIVDIDFNRVLGAWSDLTRIPLASLKKSFHMGE---AFHQHERGEISDEAFAEA 67 Query: 67 MEENCRKCSETAKVCLPKNFSIKEIFDKAISARKIN-RPMLQAALM-LRKKGFTTAILTN 124 + C E A LP ++ E F A + RP + A + LR++G +L+N Sbjct: 68 L------CHEMA---LPLSY---EQFSHGWQAVFVALRPEVIAIMHKLREQGHRVVVLSN 115 Query: 125 TWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLD 184 T +R + E++ D + S +GM KPE +IY+ +L SPS+ VF D Sbjct: 116 T---NRLHTTFWPEEYPEIRDAADHIYLSQDLGMRKPEARIYQHVLQAEGFSPSDTVFFD 172 Query: 185 DIGANLKPARDLGMVTILVQDTDTALKELEKV 216 D N++ A LG+ +ILV+D T KV Sbjct: 173 DNADNIEGANQLGITSILVKDKTTIPDYFAKV 204 >3HEA-A nrPDB Length = 271 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 39/135 (28%), Positives = 61/135 (45%), Gaps = 8/135 (5%) Query: 245 KPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPE 304 K +++F + GSG V HG+P W YQ+ L+ GYR +A D +G+G S P Sbjct: 6 KDGTQIYFKDWGSGKPVLFSHGWPLDADMWEYQMEYLSSRGYRTIAFDRRGFGRSDQPWT 65 Query: 305 IEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGM-LVWYMALFYPERVRAVASLN--TP 361 +Y + ++ ++ L L + +G GG + Y+A RV + L TP Sbjct: 66 GNDY--DTFADDIAQLIEHLDLKEVTLVGFSMGGGDVARYIARHGSARVAGLVLLGAVTP 123 Query: 362 FI---PANPNMSPLE 373 P P PL+ Sbjct: 124 IFGQKPDYPQGVPLD 138 >3WMR-A nrPDB Length = 315 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 69/304 (22%), Positives = 123/304 (40%), Gaps = 44/304 (14%) Query: 254 ELGSG-PAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE--YCM 310 +L SG P V L HG P S + + + +L +AG+ V+ D G G S+ PE E + + Sbjct: 41 DLHSGKPPVVLLHGGPGSTHDYLLAMTSLTEAGWPVVHYDQLGNGGSTHLPEKGEDFWTV 100 Query: 311 EVLCKEMVTFLDKLGLS-QAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM 369 ++ E+ L++LG++ V G WGGML A P +R + N P Sbjct: 101 QLFEDELDNLLNQLGIAGDYVLFGQSWGGMLGSVHAARRPAGLRGLVVANAP-------- 152 Query: 370 SPLESIKANPVFDYQLYFQE---------PGVAEAELEQNLSRTFKSLFRASDESVLSMH 420 S+K ++ QE P V E L+ +RT + Sbjct: 153 ---ASMK--------IWLQEMARLRALLPPDVQETLLKHEAARTTDTEEYFHAMRAFYDR 201 Query: 421 KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL 480 VC V P + + + M + Y + GP N + + W+ + Sbjct: 202 HVCR----IVPWPRDFAATFM------EIYNDPTVYTTMNGP-NEFHVIGTLRDWSVEDC 250 Query: 481 GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 I +P +++ D P + D +P ++ +E+ H +++P ++++I Sbjct: 251 LPDIQVPTMVLIGRHDEA-TPATVKPFLDLVPDVRYEVLENSSHVPHLEEPERFHEVMID 309 Query: 541 WLDS 544 +L+S Sbjct: 310 YLES 313 >3OM8-A nrPDB Length = 266 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 33/102 (32%), Positives = 57/102 (55%), Gaps = 3/102 (2%) Query: 259 PAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMV 318 P + L + + + W Q+PAL + +RVL D +G+G SS PP Y + L ++++ Sbjct: 28 PLLALSNSIGTTLHMWDAQLPALTRH-FRVLRYDARGHGASSVPPG--PYTLARLGEDVL 84 Query: 319 TFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 LD L + +A F+G GG++ ++AL P+R+ + NT Sbjct: 85 ELLDALEVRRAHFLGLSLGGIVGQWLALHAPQRIERLVLANT 126 >5EGN-A nrPDB Length = 271 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 31/105 (29%), Positives = 54/105 (51%), Gaps = 3/105 (2%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 V++++ G G + H F + W +Q AQ + V+ +D +G+G S P Sbjct: 9 VKIYYDSYGEGVPIVFLHPFSTNGGIWYFQTFPFAQTNH-VIVIDHRGHGRSDKPAT--G 65 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERV 352 Y + ++V LD L + +AVF+G+ GGM+ + L +P+RV Sbjct: 66 YSIMEHADDVVAVLDALKVDRAVFVGNSIGGMIAMQLNLDHPQRV 110 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 22/66 (33%), Positives = 35/66 (53%) Query: 473 WKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPT 532 + W K I P L+V E+D V +Q + D IP + I D GH+ Q+++P+ Sbjct: 191 FAWNIKDRLSSIQAPTLVVAGEEDLVTTVANNQLLADNIPGAELRVINDVGHFYQLERPS 250 Query: 533 EVNQIL 538 E N++L Sbjct: 251 EFNELL 256 >4UHD-A nrPDB Length = 282 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 64/296 (21%), Positives = 119/296 (40%), Gaps = 44/296 (14%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 + L F + G+G V L HGFP W+ Q L +RV+ D++G+GES P + Sbjct: 16 IELAFEDTGTGLPVLLVHGFPLDRTMWKAQREELCDE-FRVIVPDLRGFGESQVIPGV-- 72 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGH-DWGGMLVWYMALFYPERVRAVASLNTPFIPAN 366 ME + ++ + LGL+ + +G GG + + A Y +R+ + +T P + Sbjct: 73 ATMEAMADDLAGLCNHLGLTGKIVLGGLSMGGYVAFAFARKYRDRLAGLILCDTRARPDS 132 Query: 367 PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAG 426 P E+ + ++ + PG E+ L +S FR E + + + Sbjct: 133 P-----EAKENRRRVAERVRREGPGFIAEEMIPRLC--CESTFRNHPEVIEKIRQ----- 180 Query: 427 GLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILI 486 + +++P E + + G + + +C +L Sbjct: 181 -MILSAPPEGVAAAAL------------------GMAERPDSTDLLPALSCPTL------ 215 Query: 487 PALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWL 542 ++ + D + P+ + M IP + I D GH M++P V Q + +WL Sbjct: 216 ---VLVGQFDAISPPEEMEAMARTIPQSQFVVIPDAGHLPPMEQPERVTQAIREWL 268 >2O2H-A nrPDB Length = 300 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 66/307 (21%), Positives = 120/307 (39%), Gaps = 49/307 (15%) Query: 249 RLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS--APPEIE 306 R+ +++ G G A+ HG P S Y WR +P L G R++A D+ G G S +P + Sbjct: 21 RMAYIDEGKGDAIVFQHGNPTSSYLWRNIMPHLEGLG-RLVACDLIGMGASDKLSPSGPD 79 Query: 307 EYCMEVLCKEMVTFLDKLGLS-QAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPA 365 Y + D L L V + HDWG L + A + +RV+ +A + P Sbjct: 80 RYSYGEQRDFLFALWDALDLGDHVVLVLHDWGSALGFDWANQHRDRVQGIAFMEAIVTP- 138 Query: 366 NPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEA 425 + A+ + F+ E + H + Sbjct: 139 --------------------------MTWADWPPAVRGVFQGFRSPQGEPMALEHNI--- 169 Query: 426 GGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSG--FRGPLNWYRNMERNWKWA------- 476 FV ++ R +++EE+ Y + F G R L+W RN+ + + A Sbjct: 170 ---FVERVLPGAILRQLSDEEMNHYRRPFVNGGEDRRPTLSWPRNLPIDGEPAEVVALVN 226 Query: 477 -CKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVN 535 +S + +P L + AE ++ ++ ++ W P+ + H+ Q D P E+ Sbjct: 227 EYRSWLEETDMPKLFINAEPGAIITGRIRDYVRSW-PNQTEITVPGV-HFVQEDSPEEIG 284 Query: 536 QILIKWL 542 + +++ Sbjct: 285 AAIAQFV 291 >2WUG-A nrPDB Length = 291 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 73/309 (23%), Positives = 123/309 (39%), Gaps = 47/309 (15%) Query: 242 VTVKPRVRLHFVELGSG--PAVCLCHGF---PESWYSWRYQIPALAQAGYRVLAMDMKGY 296 V V ++LH+ E G G V L HG SW ++ I LA+ + VLA+D GY Sbjct: 18 VDVDGPLKLHYHEAGVGNDQTVVLLHGGGPGAASWTNFSRNIAVLARH-FHVLAVDQPGY 76 Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVA 356 G S E ++ + D+LGL + +G+ GG AL YP R + Sbjct: 77 GHSDKRAEHGQFN-RYAAMALKGLFDQLGLGRVPLVGNALGGGTAVRFALDYPARAGRLV 135 Query: 357 SLNTPFIPAN---PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASD 413 + + N P+ P E +K F A +NL + + D Sbjct: 136 LMGPGGLSINLFAPD--PTEGVKRLSKFSV-----------APTRENLEAFLRVM--VYD 180 Query: 414 ESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNW 473 +++++ V + L ++PE + +R + + F + F + W R + R Sbjct: 181 KNLITPELVDQRFAL-ASTPESLTATRAMG--------KSFAGADFEAGMMW-REVYR-- 228 Query: 474 KWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTE 533 + P L++ +D V + IP + CGHW Q++K E Sbjct: 229 ----------LRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDE 278 Query: 534 VNQILIKWL 542 N++ I++L Sbjct: 279 FNKLTIEFL 287 >1A88-A nrPDB Length = 275 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/142 (31%), Positives = 63/142 (44%), Gaps = 10/142 (7%) Query: 240 GYVTVKPRVRLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYG 297 G VT + + + G G V HG+P S W Q+ GYRV+A D +G+G Sbjct: 1 GTVTTSDGTNIFYKDWGPRDGLPVVFHHGWPLSADDWDNQMLFFLSHGYRVIAHDRRGHG 60 Query: 298 ESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHD-WGGMLVWYMALFYPERV-RAV 355 S P + M+ ++ + L L AV IGH GG + Y+A P RV +AV Sbjct: 61 RSDQPSTGHD--MDTYAADVAALTEALDLRGAVHIGHSTGGGEVARYVARAEPGRVAKAV 118 Query: 356 ASLNTPFI----PANPNMSPLE 373 P + NP+ PLE Sbjct: 119 LVSAVPPVMVKSDTNPDGLPLE 140 >3HSS-A nrPDB Length = 293 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 64/309 (20%), Positives = 111/309 (35%), Gaps = 63/309 (20%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWR-YQIPALAQAGYRVLAMDMKGYGESSAPPEIE 306 + L + + G+G V G + +W +Q+PA AGYR + D +G G + E Sbjct: 33 INLAYDDNGTGDPVVFIAGRGGAGRTWHPHQVPAFLAAGYRCITFDNRGIGATE---NAE 89 Query: 307 EYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTP----- 361 + + + + ++ L ++ A +G G + + + PE V + + T Sbjct: 90 GFTTQTMVADTAALIETLDIAPARVVGVSMGAFIAQELMVVAPELVSSAVLMATRGRLDR 149 Query: 362 ----FIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSR-TFKSLFRASD-ES 415 F A + ++ P +D A A L +N SR T D + Sbjct: 150 ARQFFNKAEAELYD-SGVQLPPTYD----------ARARLLENFSRKTLNDDVAVGDWIA 198 Query: 416 VLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKW 475 + SM + GL P +R L YRN Sbjct: 199 MFSMWPIKSTPGLRCQLDCAPQTNR----------------------LPAYRN------- 229 Query: 476 ACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVN 535 I P L++ D V P + + + D +P+ + I D GH ++P VN Sbjct: 230 --------IAAPVLVIGFADDVVTPPYLGREVADALPNGRYLQIPDAGHLGFFERPEAVN 281 Query: 536 QILIKWLDS 544 ++K+ S Sbjct: 282 TAMLKFFAS 290 >3A2L-A nrPDB Length = 309 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 40/144 (27%), Positives = 65/144 (45%), Gaps = 6/144 (4%) Query: 258 GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEM 317 P V HG P S + WR +P ++ + +A D+ G+G+S P + V + + Sbjct: 29 APVVLFLHGNPTSSHIWRNILPLVSPVAH-CIAPDLIGFGQSGKPDIAYRFFDHV--RYL 85 Query: 318 VTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKA 377 F+++ G++ A + DWG L +++A P+ VR +A + FI P A Sbjct: 86 DAFIEQRGVTSAYLVAQDWGTALAFHLAARRPDFVRGLAFME--FIRPMPTWQDFHQDHA 143 Query: 378 NPVFDYQLYFQEPGVAEAE-LEQN 400 F+ PG EA LE N Sbjct: 144 EAARAVFRKFRTPGEGEAMILEAN 167 >4DGQ-A nrPDB Length = 280 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 42/142 (29%), Positives = 65/142 (45%), Gaps = 10/142 (7%) Query: 238 SHGYVTVKPRVRLHFVELGSGPA--VCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKG 295 S G VT K V + + + G A + HG+P S W Q+ G+RV+A D +G Sbjct: 4 SMGTVTTKDGVEIFYKDWGPRDAKVIHFHHGWPLSSDDWDAQLLFFVNKGFRVVAHDRRG 63 Query: 296 YGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 +G SS + + M+ + ++KLG A+ +GH GG V + ER + Sbjct: 64 HGRSSQ--VWDGHDMDHYADDAAAVVEKLGTHGAMHVGHSTGGGEVVRYIARHGERNVSK 121 Query: 356 ASLNTPFIP------ANPNMSP 371 A L + P +NPN +P Sbjct: 122 AVLISSVPPLMVKTSSNPNGTP 143 >2XUA-A nrPDB Length = 266 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 61/122 (50%), Gaps = 3/122 (2%) Query: 256 GSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCK 315 G+ P + L + W Q+ AL++ +RVL D +G+G S AP Y +E L Sbjct: 24 GNAPWIVLSNSLGTDLSMWAPQVAALSKH-FRVLRYDTRGHGHSEAPKG--PYTIEQLTG 80 Query: 316 EMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESI 375 +++ +D L +++A F G GG+ +A + +R+ VA NT +P + ++ Sbjct: 81 DVLGLMDTLKIARANFCGLSMGGLTGVALAARHADRIERVALCNTAARIGSPEVWVPRAV 140 Query: 376 KA 377 KA Sbjct: 141 KA 142 >1A8Q-A nrPDB Length = 274 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 40/143 (27%), Positives = 64/143 (44%), Gaps = 12/143 (8%) Query: 243 TVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAP 302 T + V + + + G G V HG+P + +W+ Q+ A+ AGYR +A D +G+G S+ Sbjct: 4 TTRDGVEIFYKDWGQGRPVVFIHGWPLNGDAWQDQLKAVVDAGYRGIAHDRRGHGHST-- 61 Query: 303 PEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGM-LVWYMALFYPERVRAVASLNTP 361 P + Y + ++ L L L + H GG L Y+ R+R+ L+ Sbjct: 62 PVWDGYDFDTFADDLNDLLTDLDLRDVTLVAHSMGGGELARYVGRHGTGRLRSAVLLSA- 120 Query: 362 FIP-------ANPNMSPLESIKA 377 IP NP+ P E A Sbjct: 121 -IPPVMIKSDKNPDGVPDEVFDA 142 >1U2E-A nrPDB Length = 289 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 63/301 (20%), Positives = 118/301 (39%), Gaps = 45/301 (14%) Query: 248 VRLHFVELGSGP-AVCLCHGF---PESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPP 303 +R+HF + G G V L HG W ++ I L +AGYRV+ +D G+G+S + Sbjct: 25 LRIHFNDCGQGDETVVLLHGSGPGATGWANFSRNIDPLVEAGYRVILLDCPGWGKSDSVV 84 Query: 304 EIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFI 363 ++ + + + +D+L +++ +G+ GG L +PERV + + Sbjct: 85 NSGSRS-DLNARILKSVVDQLDIAKIHLLGNSMGGHSSVAFTLKWPERVGKLVLMGG--- 140 Query: 364 PANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVC 423 MS + + +++P + +L ++ +F SD Sbjct: 141 -GTGGMSLFTPMPTEGIKRLNQLYRQPTIENLKLMMDI-----FVFDTSD---------- 184 Query: 424 EAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRK 483 ++ E L+ M++ + +++ F KS +E N K R Sbjct: 185 -----LTDALFEARLNNMLSRRD---HLENFVKS-----------LEANPKQFPDFGPRL 225 Query: 484 ILIPA--LMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKW 541 I A L+V D + + I + DCGHW Q + NQ+++ + Sbjct: 226 AEIKAQTLIVWGRNDRFVPMDAGLRLLSGIAGSELHIFRDCGHWAQWEHADAFNQLVLNF 285 Query: 542 L 542 L Sbjct: 286 L 286 >3V1K-A nrPDB Length = 286 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 69/302 (22%), Positives = 120/302 (39%), Gaps = 52/302 (17%) Query: 250 LHFVELGSGPAVCLCHGFPES---WYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIE 306 +H+ E G+G V + HG W ++ + AGYRV+ D G+ +S A E Sbjct: 25 IHYNEAGNGETVIMLHGGGPGAGGWSNYYRNVGPFVDAGYRVILKDSPGFNKSDAVVMDE 84 Query: 307 EYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPAN 366 + + V + + +D L + +A +G+ GG AL YP+R+ + + + Sbjct: 85 QRGL-VNARAVKGLMDALDIDRAHLVGNSMGGATALNFALEYPDRIGKLILMGPGGL--G 141 Query: 367 PNM---SPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRA--SDESVLSMHK 421 P+M P+E IK ++LY AE E T K + + D+S+++ Sbjct: 142 PSMFAPMPMEGIK----LLFKLY------AEPSYE-----TLKQMLQVFLYDQSLIT--- 183 Query: 422 VCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLG 481 EE R + +++ F S + PL+ + R + K+ Sbjct: 184 ------------EELLQGRWEAIQRQPEHLKNFLISAQKAPLSTWDVTARLGEIKAKTF- 230 Query: 482 RKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHI-EDCGHWTQMDKPTEVNQILIK 540 +T +D VP W R H+ CG W Q + E N+++I Sbjct: 231 ---------ITWGRDDRFVPLDHGLKLLWNIDDARLHVFSKCGQWAQWEHADEFNRLVID 281 Query: 541 WL 542 +L Sbjct: 282 FL 283 >2PSJ-A nrPDB Length = 319 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 50/102 (49%), Gaps = 3/102 (2%) Query: 260 AVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVT 319 AV HG S Y WR+ +P + R + D+ G G+S Y + K + Sbjct: 46 AVIFLHGNATSSYLWRHVVPHIEPVA-RCIIPDLIGMGKSGKSGN-GSYRLLDHYKYLTA 103 Query: 320 FLDKLGL-SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 + + L L + +F+GHDWG L ++ A + +R++A+ + + Sbjct: 104 WFELLNLPKKIIFVGHDWGAALAFHYAYEHQDRIKAIVHMES 145 >3NWO-A nrPDB Length = 330 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 67/296 (22%), Positives = 116/296 (39%), Gaps = 36/296 (12%) Query: 263 LCHGFPESWYSWRYQIPALA-QAGYRVLAMDMKGYGESSAPPEI--EEYCMEVLCKEMVT 319 + HG P +++ I ALA + G V+ D G G S+ P+ + + ++ E Sbjct: 59 VLHGGPGMAHNYVANIAALADETGRTVIHYDQVGCGNSTHLPDAPADFWTPQLFVDEFHA 118 Query: 320 FLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANP 379 LG+ + +G WGGML +A+ P + ++A N+P S++ Sbjct: 119 VCTALGIERYHVLGQSWGGMLGAEIAVRQPSGLVSLAICNSP-----------ASMRLWS 167 Query: 380 VFDYQLYFQEPGVAEAELEQNLSR---TFKSLFRASDESVLSMHKVCEAGGLFVNSPEEP 436 L Q P A L+++ + T +A+ E VC V +P++ Sbjct: 168 EAAGDLRAQLPAETRAALDRHEAAGTITHPDYLQAAAE--FYRRHVCR----VVPTPQDF 221 Query: 437 SLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKD 496 + S E E Y GP N + + W+ + P L++ E D Sbjct: 222 ADSVAQMEAEPTVY------HTMNGP-NEFHVVGTLGDWSVIDRLPDVTAPVLVIAGEHD 274 Query: 497 FVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLD-----SDAR 547 P+ Q D IP ++ H T ++KP E ++ ++L +DAR Sbjct: 275 EA-TPKTWQPFVDHIPDVRSHVFPGTSHCTHLEKPEEFRAVVAQFLHQHDLAADAR 329 >3KXP-A nrPDB Length = 314 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 4/118 (3%) Query: 247 RVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIE 306 R+ L+ E GSGP + HG + + + L+ + +A+D +G+G S P Sbjct: 57 RITLNVREKGSGPLMLFFHGITSNSAVFEPLMIRLSDR-FTTIAVDQRGHGLSDKPET-- 113 Query: 307 EYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLN-TPFI 363 Y ++ + L A+ +GH G A YP+ VR+V +++ TP+I Sbjct: 114 GYEANDYADDIAGLIRTLARGHAILVGHSLGARNSVTAAAKYPDLVRSVVAIDFTPYI 171 >3KBB-A nrPDB Length = 216 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 91/204 (44%), Gaps = 28/204 (13%) Query: 3 LRAAVFDLDGVL--ALPAVFGVLGRTEEALALPRGLLNDAFQK--GGPEGATTRLMKGEI 58 + A +FD+DGVL P F R E+ P D ++ G PE ++ + Sbjct: 1 MEAVIFDMDGVLMDTEPLYFEAYRRVAESYGKP--YTEDLHRRIMGVPEREGLPILMEAL 58 Query: 59 TLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFT 118 + + EN +K K K +F + + K N + +A ++ K Sbjct: 59 EIKDSL----ENFKKRVHEEK---------KRVFSELL---KENPGVREALEFVKSKRIK 102 Query: 119 TAILTNTWLDDRAERDGLAQLM-CELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASP 177 A+ T+T +R+ L +L +L+ +FD ++ QV KP+P+IY +L+ L P Sbjct: 103 LALATST-----PQREALERLRRLDLEKYFDVMVFGDQVKNGKPDPEIYLLVLERLNVVP 157 Query: 178 SEVVFLDDIGANLKPARDLGMVTI 201 +VV +D + ++ A+ G+ I Sbjct: 158 EKVVVFEDSKSGVEAAKSAGIERI 181 >4G5X-A nrPDB Length = 279 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 36/127 (28%), Positives = 56/127 (44%), Gaps = 9/127 (7%) Query: 236 DMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKG 295 + SHG + V+ G G + + HG S + Q+ +RV+A D+ G Sbjct: 9 ETSHGRIAVRE-------SEGEGAPLLMIHGNSSSGAIFAPQLEGEIGKKWRVIAPDLPG 61 Query: 296 YGESS-APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRA 354 +G+S+ A Y ME M + +LG++ AV G GG + M YPE +R Sbjct: 62 HGKSTDAIDPDRSYSMEGYADAMTEVMQQLGIADAVVFGWSLGGHIGIEMIARYPE-MRG 120 Query: 355 VASLNTP 361 + TP Sbjct: 121 LMITGTP 127 >4HTA-A nrPDB Length = 288 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 38/142 (26%), Positives = 64/142 (45%), Gaps = 25/142 (17%) Query: 255 LGSGPA-VCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPP-EIEEYC-ME 311 +GSG A + L HGF W++ +P L YRV+ D G G ++ + + Y +E Sbjct: 31 IGSGEATIVLGHGFGTDQSVWKHLVPHLVD-DYRVVLYDNMGAGTTNPDYFDFDRYSNLE 89 Query: 312 VLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSP 371 +++ L+ L + +F+GH M + +ASLN P + S Sbjct: 90 GYSFDLIAILEDLKIESCIFVGHSVSAM------------IGVLASLNRPDL-----FSK 132 Query: 372 LESIKANPVF----DYQLYFQE 389 + I A+P + DYQ F++ Sbjct: 133 IVMISASPRYVNDVDYQGGFEQ 154 >4JB3-A nrPDB Length = 228 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 21/59 (35%), Positives = 33/59 (55%) Query: 143 LKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTI 201 L + D L S Q+G KP P+I+ F++ PSE +F+DD +N+ ++LG T Sbjct: 152 LNDYCDKLYLSYQLGHTKPAPEIFDFMIKDSHVIPSETLFVDDGSSNIHIGKELGFETF 210 >4CCW-A nrPDB Length = 299 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 62/298 (20%), Positives = 116/298 (38%), Gaps = 65/298 (21%) Query: 258 GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEM 317 P + L HG S W I A + YR A+D+ G S P + + + Sbjct: 54 APPLVLLHGALFSSTMWYPNI-ADWSSKYRTYAVDIIGDKNKSIPENLSGTRTD-YANWL 111 Query: 318 VTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKA 377 + D LG+ ++ IG GG+ L PERV++ A L SP E+ Sbjct: 112 LDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAIL-----------SPAETFLP 160 Query: 378 NPVFDYQLYFQEPGV-AEAELEQNLSRTFKSLFRASDESVLS--MHKVCEAGGLFVNSPE 434 F + Y G+ A +E+ L+ + +D++VL K +AG ++ + Sbjct: 161 ---FHHDFYKYALGLTASNGVEKFLN------WMMTDQNVLHPIFVKQFQAGVMWQDGSR 211 Query: 435 EPS-----LSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPAL 489 P+ + T+EE+ R +P L Sbjct: 212 NPNPKADGFPYVFTDEEL----------------------------------RSARVPIL 237 Query: 490 MVTAEKDFVLVPQMSQH-MEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDA 546 ++ E + + P + H ++P ++ I++ GH M++P VN+ ++++ +++ Sbjct: 238 LLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVLSMEQPAYVNERVMRFFNAET 295 >3V48-A nrPDB Length = 268 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 47/104 (45%), Gaps = 6/104 (5%) Query: 258 GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEI--EEYCMEVLCK 315 P V L G S W Q+ L Q Y+V+ D +G G + P+ E+Y + + Sbjct: 15 APVVVLISGLGGSGSYWLPQLAVLEQE-YQVVCYDQRGTGNN---PDTLAEDYSIAQMAA 70 Query: 316 EMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLN 359 E+ L G+ +GH G ++ +AL YP V + S+N Sbjct: 71 ELHQALVAAGIEHYAVVGHALGALVGMQLALDYPASVTVLISVN 114 >4RNC-A nrPDB Length = 310 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 36/149 (24%), Positives = 66/149 (44%), Gaps = 21/149 (14%) Query: 257 SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKE 316 +G + L HG+ +S W Q+ A A YR++A+D++G+G S AP + + Sbjct: 44 AGTPLVLLHGWAQSSQCWGEQVLADLAADYRLIAVDLRGHGYSDAPESGYDDSAN-WAGD 102 Query: 317 MVTFLDKLGLSQ-AVFIGHDWGGMLVW-YMA------------------LFYPERVRAVA 356 + L G+++ A+ +G +GG+++ Y+A + E+ V Sbjct: 103 VAAVLAAEGVTENAILLGWSYGGLVICDYLAAHGTGAVAGAVLVGAITSIGRGEKGGKVG 162 Query: 357 SLNTPFIPANPNMSPLESIKANPVFDYQL 385 S +P + P E+I+A F L Sbjct: 163 SAMRSAVPGAMSEDPREAIRALGAFGNAL 191 >1DWO-A nrPDB Length = 262 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/113 (30%), Positives = 56/113 (49%), Gaps = 13/113 (11%) Query: 244 VKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPP 303 + V HFV + + +CHG +W W PAL +AG++V A+DM G P Sbjct: 2 ISKMVTAHFVLIHT-----ICHG---AWI-WHKLKPALERAGHKVTALDMAASGID--PR 50 Query: 304 EIEEY-CMEVLCKEMVTFLDKLGLSQAVFI-GHDWGGMLVWYMALFYPERVRA 354 +IE+ + + ++TFL+KL + V I G G+ + A Y +++ A Sbjct: 51 QIEQINSFDEYSEPLLTFLEKLPQGEKVIIVGESCAGLNIAIAADRYVDKIAA 103 >2WJ4-A nrPDB Length = 276 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 4/97 (4%) Query: 257 SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKE 316 GPA+ L G+ ++Y I L A +RV+ + +G+G S P E+ ++ + K+ Sbjct: 26 DGPAILLLPGWCHDHRVYKYLIQEL-DADFRVIVPNWRGHGLS--PSEVPDFGYQEQVKD 82 Query: 317 MVTFLDKLGLSQAVFIGHDWGG-MLVWYMALFYPERV 352 + LD+LG+ + + H GG +LV + PER Sbjct: 83 ALEILDQLGVETFLPVSHSHGGWVLVELLEQAGPERA 119 >2XMZ-A nrPDB Length = 269 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 62/299 (20%), Positives = 114/299 (38%), Gaps = 51/299 (17%) Query: 257 SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKE 316 + + HGF ++ I Y V+ +D+ G+GE + + E + + + Sbjct: 15 TNQVLVFLHGFLSDSRTYHNHIEKFTD-NYHVITIDLPGHGEDQSSMD-ETWNFDYITTL 72 Query: 317 MVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIK 376 + LDK G+ GG + Y A+ N ++ Sbjct: 73 LDRILDKYKDKSITLFGYSMGGRVALYYAI-------------------NGHI------- 106 Query: 377 ANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGG--LFVNSPE 434 P+ + L PG+ E L R RA KV + G LFVN E Sbjct: 107 --PISNLILESTSPGIKEE--ANQLERRLVDDARA---------KVLDIAGIELFVNDWE 153 Query: 435 EPSL--SRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLG---RKILIPAL 489 + L S++ EIQ ++Q + S + P + + +L ++I +P L Sbjct: 154 KLPLFQSQLELPVEIQHQIRQQRLS--QSPHKMAKALRDYGTGQMPNLWPRLKEIKVPTL 211 Query: 490 MVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARN 548 ++ E D V Q+++ M + IP+ K I GH ++ E + +++ +L + + Sbjct: 212 ILAGEYDEKFV-QIAKKMANLIPNSKCKLISATGHTIHVEDSDEFDTMILGFLKEEQND 269 >4NMW-A nrPDB Length = 259 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 44/166 (26%), Positives = 75/166 (45%), Gaps = 29/166 (17%) Query: 261 VCLCHGF---PESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEM 317 + L HG+ E W+ R ++ + + + +D+ GYG SS + +EM Sbjct: 19 LVLLHGWGLNAEVWHCIREEL----GSHFTLHLVDLPGYGRSSGFGAMT-------LEEM 67 Query: 318 VTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASL-NTPFIPAN---PNMSP-- 371 + K QA+++G GG++ MAL +PERV+A+ ++ ++P A P + P Sbjct: 68 TAQVAKNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAREGWPGIKPEI 127 Query: 372 LESIKANPVFDYQ------LYFQEPGVAEAELEQNLSRTFKSLFRA 411 L + D+Q L Q G A + +RT KS+ A Sbjct: 128 LGGFQQQLSDDFQRTVERFLALQTLGTETARQD---ARTLKSVVLA 170 >4FBL-A nrPDB Length = 281 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 32/120 (26%), Positives = 51/120 (42%), Gaps = 4/120 (3%) Query: 255 LGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLC 314 +GS V + HGF S S R+ A+AGY V + G+G + P E+ Sbjct: 48 VGSRIGVLVSHGFTGSPQSMRFLAEGFARAGYTVATPRLTGHG--TTPAEMAASTASDWT 105 Query: 315 KEMVTFLDKLGLSQAVFI--GHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPL 372 ++V + L V G GG L + A +PER + +N +P+++ L Sbjct: 106 ADIVAAMRWLEERCDVLFMTGLSMGGALTVWAAGQFPERFAGIMPINAALRMESPDLAAL 165 >6AP7-A nrPDB Length = 269 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 8/101 (7%) Query: 255 LGSGPAV-CLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEY----C 309 +GSG V L HGF +W +P + YRV+ D+ G S P+ ++ Sbjct: 16 VGSGERVLVLAHGFGTDQSAWNRILPFFLR-DYRVVLYDLVCAG--SVNPDFFDFRRYTT 72 Query: 310 MEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPE 350 ++ +++ LD LG+ Q ++GH M+ ++ PE Sbjct: 73 LDPYVDDLLHILDALGIDQCAYVGHSVSAMIGILASIRRPE 113 >6EIC-C nrPDB Length = 279 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 6/122 (4%) Query: 261 VCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAP----PEIEEYCMEVLCKE 316 V L HG E + + L AG A+D +G+G S +I EY + Sbjct: 33 VVLAHGLGEHARRYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRDISEYTADFDTLV 92 Query: 317 MVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIK 376 + + G + + +GH GG +V+ + P+ + L+ P + A +SP+ ++ Sbjct: 93 GIATREYPGCKR-IVLGHSMGGGIVFAYGVERPDNYDLMV-LSAPAVAAQDLVSPVVAVA 150 Query: 377 AN 378 A Sbjct: 151 AK 152 >3BF8-A nrPDB Length = 255 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 51/263 (19%), Positives = 90/263 (34%), Gaps = 55/263 (20%) Query: 286 YRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMA 345 + ++ +D++ +G S P + M +++V LD + +A FIGH GG V + Sbjct: 43 HNIIQVDVRNHGLSPREPVMNYPAM---AQDLVDTLDAQQIDKATFIGHSMGGKAVMALT 99 Query: 346 LFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTF 405 P+R+ L +I PV DY + Sbjct: 100 ALAPDRI-----------------DKLVAIDIAPV-DYHV-------------------- 121 Query: 406 KSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNW 465 R DE +++ V E+ + E IQF ++ F W Sbjct: 122 ----RRHDEIFAAINAVSESDAQTRQQAAAIMRQHLNEEGVIQFLLKSFVDG------EW 171 Query: 466 YRNMERNWKWACKSLGRKIL----IPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIED 521 N+ W +G + + PAL + + Q + P + I Sbjct: 172 RFNVPVLWDQYPHIVGWEKIPAWDHPALFIPGGNSPYVSEQYRDDLLAQFPQARAHVIAG 231 Query: 522 CGHWTQMDKPTEVNQILIKWLDS 544 GHW +KP V + + ++L+ Sbjct: 232 AGHWVHAEKPDAVLRAIRRYLND 254 >4QLA-A nrPDB Length = 447 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 46/105 (43%), Gaps = 11/105 (10%) Query: 261 VCLCHGFPESWYSWRYQIPALAQA------GYRVLAMDMKGYGESSAP--PEIEEYCMEV 312 + L HG+P S + IP L ++A + GYG S A P + + V Sbjct: 134 LLLLHGWPGSVREFYEAIPHLTAVSKDRNFALEIIAPSLPGYGFSDAAVRPGLAAAEVAV 193 Query: 313 LCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVAS 357 + K ++ +LG Q G DWG ++ MA F+P+ + S Sbjct: 194 IFKNLMA---RLGYKQYYVQGGDWGALIGSAMATFFPKEIIGFHS 235 >4IH4-A nrPDB Length = 267 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 8/101 (7%) Query: 255 LGSGPAVC-LCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEY----C 309 +G+G + L HGF +W +P Q YRV+ D+ G S P+ ++ Sbjct: 15 VGTGDRILFLAHGFGTDQSAWHLILPYFTQ-NYRVVLYDLVCAG--SVNPDYFDFNRYTT 71 Query: 310 MEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPE 350 ++ +++ +D LG+ ++GH M+ ++ PE Sbjct: 72 LDPYVDDLLNIVDSLGIQNCAYVGHSVSAMIGIIASIRRPE 112 >1IMJ-A nrPDB Length = 210 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 34/92 (36%), Positives = 43/92 (46%), Gaps = 11/92 (11%) Query: 256 GSGPA---VCLCHGFPESWYSWRY--QIPALAQAGYRVLAMDMKGYG---ESSAPPEIEE 307 GSG A V L HG S +W+ + LAQAGYR +A+D+ G G E++AP I E Sbjct: 27 GSGQARFSVLLLHGIRFSSETWQNLGTLHRLAQAGYRAVAIDLPGLGHSKEAAAPAPIGE 86 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGM 339 +V D L L V I GM Sbjct: 87 LAPGSFLAAVV---DALELGPPVVISPSLSGM 115 >1OIL-A nrPDB Length = 320 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 40/96 (41%), Gaps = 7/96 (7%) Query: 266 GFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLG 325 G E WY + L Q G V ++ G+ P E L + T L G Sbjct: 25 GVLEYWYGIQED---LQQRGATVYVANLSGFQSDDGPNGRGEQ----LLAYVKTVLAATG 77 Query: 326 LSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTP 361 ++ +GH GG+ Y+A P+ V +V ++ TP Sbjct: 78 ATKVNLVGHSQGGLTSRYVAAVAPDLVASVTTIGTP 113 >5YHP-A nrPDB Length = 355 Score = 38.1 bits (87), Expect = 0.011, Method: Compositional matrix adjust. Identities = 32/116 (27%), Positives = 51/116 (43%), Gaps = 6/116 (5%) Query: 244 VKPRVRLHFVELGS--GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSA 301 V P RL E G+ G V HG P S YR++ D +G GES+ Sbjct: 54 VSPLHRLSIKEYGNPQGKPVVFLHGGPGGGAS-DSDARRFNPTTYRIVLFDQRGSGESTP 112 Query: 302 PPEIEEYCMEVLCKEMVTFLD--KLGLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 +E+ + L +++ + ++G + VF G WG L A +P RV+++ Sbjct: 113 ASCLEDNTTQALVEDIEKIREFLQVGAAWHVF-GGSWGSTLALAYAQAHPARVKSL 167 >5XKS-A nrPDB Length = 256 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 45/193 (23%), Positives = 75/193 (38%), Gaps = 26/193 (13%) Query: 256 GSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCK 315 G+ + + HGF S S R A +AGY V +KG+G E + C+ Sbjct: 18 GNDIGILVLHGFTGSPQSMRPLGEAYHEAGYTVCGPRLKGHGTHYEDME------KTTCQ 71 Query: 316 EMVTFLD------KLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM 369 + + ++ K G GG L YMA +PE + +A +N A NM Sbjct: 72 DWIDSVEAGYEWLKNRCGTIFVTGLSMGGTLTLYMAEHHPE-ICGIAPIN-----AAINM 125 Query: 370 SPLESIKANPVFDYQLYF-------QEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKV 422 L A V D + ++PGV E E+ + + + + + + +HK+ Sbjct: 126 PALAGALAG-VGDLPRFLDAIGSDIKKPGVKELAYEKTPAASIRQIVQLMERVKTDLHKI 184 Query: 423 CEAGGLFVNSPEE 435 LF + + Sbjct: 185 TCPAILFCSDEDH 197 >1AZW-A nrPDB Length = 313 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 30/118 (25%), Positives = 51/118 (43%), Gaps = 9/118 (7%) Query: 240 GYVTVKPRVRLHFVELGS--GPAVCLCHGFPESWYS---WRYQIPALAQAGYRVLAMDMK 294 G + V R L+F + G+ G V + HG P + R+ PA YR++ D + Sbjct: 14 GSLKVDDRHTLYFEQCGNPHGKPVVMLHGGPGGGCNDKMRRFHDPA----KYRIVLFDQR 69 Query: 295 GYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERV 352 G G S+ ++ + L ++ LG+ + G WG L A +P++V Sbjct: 70 GSGRSTPHADLVDNTTWDLVADIERLRTHLGVDRWQVFGGSWGSTLALAYAQTHPQQV 127 >6COB-A nrPDB Length = 260 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 7/102 (6%) Query: 264 CHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDK 323 CHG +W W P L AG+RV A+++ G P + E E K ++ L Sbjct: 14 CHG---AWI-WYKLKPLLESAGHRVTAVELAASGIDPRPIQAVETVDE-YSKPLIETLKS 68 Query: 324 LGLSQAV-FIGHDWGGMLVWYMALFYPERVRAVASLNTPFIP 364 L ++ V +G +GG+ + A +P +++ + LN F+P Sbjct: 69 LPENEEVILVGFSFGGINIALAADIFPAKIKVLVFLNA-FLP 109 >3P2M-A nrPDB Length = 330 Score = 37.0 bits (84), Expect = 0.022, Method: Compositional matrix adjust. Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 4/97 (4%) Query: 256 GSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCK 315 GS P V HG ++ ++W I L G LA+D+ G+G SA E Y ++ + Sbjct: 79 GSAPRVIFLHGGGQNAHTWDTVIVGL---GEPALAVDLPGHGH-SAWREDGNYSPQLNSE 134 Query: 316 EMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERV 352 + L +L +G GG+ +A P+ V Sbjct: 135 TLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLV 171 >1Y7H-A nrPDB Length = 268 Score = 37.0 bits (84), Expect = 0.024, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 3/114 (2%) Query: 258 GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEM 317 G L HG +SW P L AG++V A+D+ G E E + + Sbjct: 4 GKHFVLVHGACHGGWSWYKLKPLLEAAGHKVTALDLAASGTDLRKIE-ELRTLYDYTLPL 62 Query: 318 VTFLDKLGLSQAV-FIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMS 370 + ++ L + V +GH GGM + YP+++ A L F+P + + S Sbjct: 63 MELMESLSADEKVILVGHSLGGMNLGLAMEKYPQKIYAAVFL-AAFMPDSVHNS 115 >5OLW-A nrPDB Length = 227 Score = 37.0 bits (84), Expect = 0.024, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 91/207 (43%), Gaps = 26/207 (12%) Query: 3 LRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKG---EIT 59 +A +FDLDGV+ A + R +ALA G+ G + +KG E + Sbjct: 2 FKAVLFDLDGVITDTAEYHF--RAWKALAEEIGI-------NGVDRQFNEQLKGVSREDS 52 Query: 60 LSQWIPLMEENCRKCSETAKVCLPKNFS-IKEIFDKAISARKINRPMLQAALMLRKKGFT 118 L + + L ++ E ++ KN + +K I D +S + +LQ LR Sbjct: 53 LQKILDLADKKV-SAEEFKELAKRKNDNYVKMIQD--VSPADVYPGILQLLKDLRSNKIK 109 Query: 119 TAILTNTWLDDRAERDG--LAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKAS 176 A+ + A ++G L + M L +FD + + +V KP P I+ + + Sbjct: 110 IALAS-------ASKNGPFLLERM-NLTGYFDAIADPAEVAASKPAPDIFIAAAHAVGVA 161 Query: 177 PSEVVFLDDIGANLKPARDLGMVTILV 203 PSE + L+D A ++ +D G + I V Sbjct: 162 PSESIGLEDSQAGIQAIKDSGALPIGV 188 >1TAH-B nrPDB Length = 318 Score = 37.0 bits (84), Expect = 0.025, Method: Compositional matrix adjust. Identities = 26/110 (23%), Positives = 43/110 (39%), Gaps = 16/110 (14%) Query: 261 VCLCHGFPES---------WYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCME 311 V L HG + WY + L G +V ++ G+ P E + Sbjct: 10 VILVHGLAGTDKFANVVDYWYGIQSD---LQSHGAKVYVANLSGFQSDDGPNGRGEQLLA 66 Query: 312 VLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTP 361 + + L G ++ IGH GG+ Y+A P+ V +V ++ TP Sbjct: 67 YVKQ----VLAATGATKVNLIGHSQGGLTSRYVAAVAPQLVASVTTIGTP 112 >1SCK-A nrPDB Length = 257 Score = 35.4 bits (80), Expect = 0.072, Method: Compositional matrix adjust. Identities = 32/112 (28%), Positives = 53/112 (47%), Gaps = 13/112 (11%) Query: 251 HFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEY-C 309 HFV + + +CHG +W W P L G++V A+D+ G P +IEE Sbjct: 5 HFVLIHT-----ICHG---AWI-WHKLKPLLEALGHKVTALDLAASGVD--PRQIEEIGS 53 Query: 310 MEVLCKEMVTFLDKLGLSQAV-FIGHDWGGMLVWYMALFYPERVRAVASLNT 360 + + ++TFL+ L + V +G GG+ + A Y E++ A N+ Sbjct: 54 FDEYSEPLLTFLEALPPGEKVILVGESCGGLNIAIAADKYCEKIAAAVFHNS 105 >3RLI-A nrPDB Length = 270 Score = 35.0 bits (79), Expect = 0.085, Method: Compositional matrix adjust. Identities = 36/118 (30%), Positives = 55/118 (46%), Gaps = 12/118 (10%) Query: 257 SGP-AVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYG---ESSAPPEIEEYCMEV 312 +GP V L HGF + +S R A A+AGY V +KG+G E ++ V Sbjct: 38 NGPVGVLLVHGFTGTPHSMRPLAEAYAKAGYTVCLPRLKGHGTHYEDMERTTFHDWVASV 97 Query: 313 LCKEMVTFLDKLGLSQAVFI-GHDWGGMLVWYMALFYPERVRAV---ASLNTPFIPAN 366 +E +L + Q +F+ G GG L Y+A +P+ V A+++ P I A Sbjct: 98 --EEGYGWLKQ--RCQTIFVTGLSMGGTLTLYLAEHHPDICGIVPINAAVDIPAIAAG 151 >2YYS-A nrPDB Length = 286 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 29/120 (24%), Positives = 58/120 (48%), Gaps = 6/120 (5%) Query: 240 GYVTVKPRVRLHFVELG--SGPAVCLCHGFPE-SWYSWRYQIPALAQAGYRVLAMDMKGY 296 GYV V L+ ++G GPA+ + HG P + Y R + + G+RV+ D +G Sbjct: 6 GYVPVG-EAELYVEDVGPVEGPALFVLHGGPGGNAYVLREGLQDYLE-GFRVVYFDQRGS 63 Query: 297 GES-SAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 G S P + + ++ L ++ + + LG+ + + H +G ++ + +P+ A+ Sbjct: 64 GRSLELPQDPRLFTVDALVEDTLLLAEALGVERFGLLAHGFGAVVALEVLRRFPQAEGAI 123 >4CCY-A nrPDB Length = 296 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 38/125 (30%), Positives = 53/125 (42%), Gaps = 6/125 (4%) Query: 249 RLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIE 306 + H + G P++ L HG S W I A + + +R A+D+ G S P Sbjct: 43 KTHIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWS-SQFRTYAVDIIGDKNKSIPSAAM 101 Query: 307 EYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERV-RAVA-SLNTPFIP 364 E + + M D LGL A G GG + L PERV RAV S FI Sbjct: 102 ETRAD-FAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS 160 Query: 365 ANPNM 369 +P++ Sbjct: 161 FHPDV 165 Score = 29.3 bits (64), Expect = 5.1, Method: Compositional matrix adjust. Identities = 14/62 (22%), Positives = 34/62 (54%), Gaps = 1/62 (1%) Query: 482 RKILIPALMVTAEKDFVLVPQMS-QHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 + I +P L++ E + + QM+ + +P ++ +++ GH +++P VNQ ++ Sbjct: 230 KSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLSLEQPEYVNQRVLS 289 Query: 541 WL 542 +L Sbjct: 290 FL 291 >1QTR-A nrPDB Length = 317 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 19/67 (28%), Positives = 29/67 (43%) Query: 286 YRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMA 345 Y+VL D +G G S ++ L ++ + G+ Q + G WG L A Sbjct: 64 YKVLLFDQRGCGRSRPHASLDNNTTWHLVADIERLREMAGVEQWLVFGGSWGSTLALAYA 123 Query: 346 LFYPERV 352 +PERV Sbjct: 124 QTHPERV 130 >2WFL-A nrPDB Length = 264 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 49/115 (42%), Gaps = 16/115 (13%) Query: 263 LCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYG-------ESSAPPEIEEYCMEVLCK 315 L HG + W P L AG++V A+D+ G E + E MEV+ Sbjct: 15 LVHGGCLGAWIWYKLKPLLESAGHKVTAVDLSAAGINPRRLDEIHTFRDYSEPLMEVMAS 74 Query: 316 EMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMS 370 + V +GH +GGM + YPE++ +VA + +P +PN S Sbjct: 75 IPPD-------EKVVLLGHSFGGMSLGLAMETYPEKI-SVAVFMSAMMP-DPNHS 120 >4GW3-A nrPDB Length = 307 Score = 33.9 bits (76), Expect = 0.20, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 12/104 (11%) Query: 261 VCLCHG---FPE-SWYSWRYQIP-ALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCK 315 + L HG F E + + Y I AL Q G++V + + + E + L + Sbjct: 27 IVLVHGLAGFNEIVGFPYFYGIADALRQDGHQVFTASLSAFNSN-------EVRGKQLWQ 79 Query: 316 EMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLN 359 + T L + + FIGH G + Y+A YP+ V +V S+N Sbjct: 80 FVQTLLQETQAKKVNFIGHSQGPLACRYVAANYPDSVASVTSIN 123 >3O4I-A nrPDB Length = 582 Score = 33.1 bits (74), Expect = 0.28, Method: Compositional matrix adjust. Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 12/97 (12%) Query: 258 GPAVCLCHG--FPESWYSWRYQIPALAQAGYRVLAMDMK---GYGESSAPPEIEEYCMEV 312 GP V L HG F E SW +LA AG+ V+ + + GYGE I + C Sbjct: 360 GPTVVLVHGGPFAEDSDSWDTFAASLAAAGFHVVMPNYRGSTGYGEEWRLKIIGDPCGGE 419 Query: 313 L--CKEMVTFLDKLGLSQAVFI-GHDWGGMLVWYMAL 346 L + + GL+ ++I G+ +GG YM L Sbjct: 420 LEDVSAAARWARESGLASELYIMGYSYGG----YMTL 452 >2YY6-A nrPDB Length = 213 Score = 32.7 bits (73), Expect = 0.42, Method: Compositional matrix adjust. Identities = 32/126 (25%), Positives = 56/126 (44%), Gaps = 16/126 (12%) Query: 112 LRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLD 171 L+ KGF A+++N L++ +++ + L +FD ++ G KP P L+ Sbjct: 93 LKSKGFKLAVVSNK-LEELSKK---ILDILNLSGYFDLIVGGDTFGEKKPSPTPVLKTLE 148 Query: 172 TLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTS 231 L P + + + D A+++ + G T TAL + G LN+ P T Sbjct: 149 ILGEEPEKALIVGDTDADIEAGKRAG--------TKTAL----ALWGYVKLNSQIPDFTL 196 Query: 232 CNPSDM 237 PSD+ Sbjct: 197 SRPSDL 202 >3FCY-A nrPDB Length = 346 Score = 32.7 bits (73), Expect = 0.46, Method: Compositional matrix adjust. Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 1/45 (2%) Query: 256 GSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 G PA+ HG+ + W ++ +A AG+ V+AMD++G G S Sbjct: 106 GKHPALIRFHGYSSNSGDWNDKLNYVA-AGFTVVAMDVRGQGGQS 149 >1M33-A nrPDB Length = 258 Score = 31.6 bits (70), Expect = 0.92, Method: Compositional matrix adjust. Identities = 23/100 (23%), Positives = 48/100 (48%), Gaps = 8/100 (8%) Query: 261 VCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTF 320 + L HG+ + WR I + + + +D+ G+G S + +M Sbjct: 16 LVLLHGWGLNAEVWRC-IDEELSSHFTLHLVDLPGFGRSRGFGALS-------LADMAEA 67 Query: 321 LDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 + + +A+++G GG++ +AL +PERVRA+ ++ + Sbjct: 68 VLQQAPDKAIWLGWSLGGLVASQIALTHPERVRALVTVAS 107 >6HIX-BG nrPDB Length = 378 Score = 31.6 bits (70), Expect = 0.96, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 29/56 (51%), Gaps = 2/56 (3%) Query: 310 MEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALF--YPERVRAVASLNTPFI 363 +E C+ + +D L + F+ + +G ++ MA +P RV + SL+TP + Sbjct: 126 LEQSCQRICAVMDALDVRWTHFLTYSYGALVAVRMASSQEFPHRVGTLMSLDTPLV 181 >4HXF-B nrPDB Length = 622 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 24/113 (21%), Positives = 48/113 (42%), Gaps = 13/113 (11%) Query: 207 DTALKELEKVTGI--QLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLC 264 D ++L G+ + L T P D+ +KP ++ E P + Sbjct: 329 DGEERQLTDYNGLIFKKLKTFEPRHFRFKSIDLELDGWYIKPEIK----EGEKAPVIVFV 384 Query: 265 HGFPESWYSW--RYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCK 315 HG P+ Y + +Y++ +A GY ++ ++ +G S E++ + VL + Sbjct: 385 HGGPKGMYGYYFKYEMQLMASKGYYIVYVNPRGSNGYS-----EDFALRVLER 432 >2ZIG-A nrPDB Length = 297 Score = 29.6 bits (65), Expect = 3.7, Method: Compositional matrix adjust. Identities = 18/62 (29%), Positives = 27/62 (43%), Gaps = 3/62 (4%) Query: 423 CEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGR 482 E G+F+ P EP + + EI++ + Q K G+R P R R K R Sbjct: 146 VEGRGVFLGKPYEPG---AIIKTEIEYILMQRKPGGYRKPTQEQREKSRLPKEDFHRFFR 202 Query: 483 KI 484 +I Sbjct: 203 QI 204 >1TE2-A nrPDB Length = 226 Score = 29.6 bits (65), Expect = 3.7, Method: Compositional matrix adjust. Identities = 27/120 (22%), Positives = 54/120 (45%), Gaps = 8/120 (6%) Query: 88 IKEIFDKAISARKINRPML----QAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCEL 143 ++ + +AIS + RP+L +A + +++G + + + L + M +L Sbjct: 78 VERVIARAISLVEETRPLLPGVREAVALCKEQGLLVGLASASPLHMLEK----VLTMFDL 133 Query: 144 KMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILV 203 + FD L + ++ KP PQ+Y L P V L+D + ++ M +I+V Sbjct: 134 RDSFDALASAEKLPYSKPHPQVYLDCAAKLGVDPLTCVALEDSVNGMIASKAARMRSIVV 193 >4G9B-A nrPDB Length = 243 Score = 29.6 bits (65), Expect = 4.0, Method: Compositional matrix adjust. Identities = 15/60 (25%), Positives = 28/60 (46%) Query: 142 ELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTI 201 EL+ F F ++ Q+ KP+P+I+ L P + ++D A + GM ++ Sbjct: 131 ELREFFTFCADASQLKNSKPDPEIFLAACAGLGVPPQACIGIEDAQAGIDAINASGMRSV 190 >5JRK-A nrPDB Length = 756 Score = 29.3 bits (64), Expect = 4.2, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 23/47 (48%), Gaps = 6/47 (12%) Query: 259 PAVCLCHG------FPESWYSWRYQIPALAQAGYRVLAMDMKGYGES 299 PAV + HG F E W Y + LA+ GY VL ++ G+S Sbjct: 475 PAVVVTHGTDADDRFAEPANQWNYPVQLLAERGYVVLLLNDPSPGQS 521 >3BMB-A nrPDB Length = 136 Score = 28.9 bits (63), Expect = 5.9, Method: Compositional matrix adjust. Identities = 25/99 (25%), Positives = 38/99 (38%), Gaps = 9/99 (9%) Query: 200 TILVQDTDTA----LKELEKVTGIQL---LNTPAPLPTSCNPSDMSHGYVTVKPRVRLHF 252 TI++ D D L E G+ + LN C+P +M H VT+ RV+ F Sbjct: 5 TIIINDLDAERIDILLEQPAYAGLPIADALNAELDRAQMCSPEEMPHDVVTMNSRVK--F 62 Query: 253 VELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAM 291 L G +P Q+ +A G +L + Sbjct: 63 RNLSDGEVRVRTLVYPAKMTDSNTQLSVMAPVGAALLGL 101 >1R3D-A nrPDB Length = 264 Score = 28.9 bits (63), Expect = 6.1, Method: Compositional matrix adjust. Identities = 24/102 (23%), Positives = 43/102 (42%), Gaps = 14/102 (13%) Query: 249 RLHFVE-LGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 +LHF + P V L HG S W+ + LA+ L +D+ G+G + E Sbjct: 6 QLHFAKPTARTPLVVLVHGLLGSGADWQPVLSHLARTQCAALTLDLPGHGTNP-----ER 60 Query: 308 YCMEVLCKEMVTFLDKLGLSQ------AVFIGHDWGGMLVWY 343 +C E V +++ + + +G+ GG L+ + Sbjct: 61 HCDNF--AEAVEMIEQTVQAHVTSEVPVILVGYSLGGRLIMH 100 >3CC1-A nrPDB Length = 433 Score = 28.9 bits (63), Expect = 6.6, Method: Compositional matrix adjust. Identities = 12/28 (42%), Positives = 16/28 (57%) Query: 496 DFVLVPQMSQHMEDWIPHLKRGHIEDCG 523 D+ L+ QM + E W H+ GH DCG Sbjct: 246 DWSLLYQMFERCEVWEKHIGTGHWPDCG 273 >6CL4-A nrPDB Length = 313 Score = 28.9 bits (63), Expect = 6.8, Method: Compositional matrix adjust. Identities = 15/53 (28%), Positives = 30/53 (56%), Gaps = 4/53 (7%) Query: 311 EVLCKEMVTFLDKL----GLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLN 359 E+ ++++ F+ K+ G ++ IGH G + Y+A +PE + +V S+N Sbjct: 75 ELRGEQLLEFVRKVQAETGAAKVNLIGHSQGPLACRYVAATHPELIASVTSVN 127 >2L0Q-A nrPDB Length = 80 Score = 28.5 bits (62), Expect = 7.1, Method: Composition-based stats. Identities = 19/63 (30%), Positives = 33/63 (52%), Gaps = 4/63 (6%) Query: 162 EPQIYKFLLDTLKASPSEV----VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVT 217 E ++ K +++ L +EV F+DD+GA+ +L M DT+ +E EK+T Sbjct: 8 EERVKKIIVEQLGVDEAEVKNEASFVDDLGADSLDTVELVMALEEEFDTEIPDEEAEKIT 67 Query: 218 GIQ 220 +Q Sbjct: 68 TVQ 70 >4KNV-A nrPDB Length = 241 Score = 28.5 bits (62), Expect = 8.1, Method: Compositional matrix adjust. Identities = 19/80 (23%), Positives = 37/80 (46%), Gaps = 4/80 (5%) Query: 106 LQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQI 165 ++A L +K +LTN D + +R+ + C+ +FD ++ + KP P I Sbjct: 109 VKAMLTELRKEVRLLLLTNG--DRQTQREKIEACACQ--SYFDAVVVGGEQREEKPAPSI 164 Query: 166 YKFLLDTLKASPSEVVFLDD 185 + + + L P + V + D Sbjct: 165 FYYCCNLLGVQPGDCVMVGD 184 >2GFH-A nrPDB Length = 260 Score = 28.5 bits (62), Expect = 8.1, Method: Compositional matrix adjust. Identities = 20/80 (25%), Positives = 36/80 (45%), Gaps = 4/80 (5%) Query: 106 LQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQI 165 ++A L +K +LTN D + +R+ + C+ +FD ++ + KP P I Sbjct: 126 VKAMLTELRKEVRLLLLTNG--DRQTQREKIEACACQ--SYFDAIVIGGEQKEEKPAPSI 181 Query: 166 YKFLLDTLKASPSEVVFLDD 185 + D L P + V + D Sbjct: 182 FYHCCDLLGVQPGDCVMVGD 201 >3HLT-A nrPDB Length = 266 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 27/108 (25%), Positives = 44/108 (40%), Gaps = 7/108 (6%) Query: 133 RDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFL-DDIGANLK 191 +DGLA ++ ++ + KPE + L P E V + DD ++ Sbjct: 152 KDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVG 211 Query: 192 PARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSH 239 A+D+GM+ ILV+ + EK+ N P L P + H Sbjct: 212 GAQDVGMLGILVKTGKYRASDEEKI------NPPPYLTCESFPHAVDH 253 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4Y2Y-A nrPDB 801 0.0 1CR6-A nrPDB 753 0.0 5Y6Y-B nrPDB 284 5e-77 2E3J-A nrPDB 260 1e-69 4NZZ-A nrPDB 249 3e-66 2B0C-A nrPDB 238 6e-63 5UXZ-A nrPDB 227 8e-60 3WMR-A nrPDB 210 2e-54 2O2H-A nrPDB 208 5e-54 3NWO-A nrPDB 207 1e-53 1U2E-A nrPDB 202 4e-52 2WUG-A nrPDB 197 9e-51 4UHD-A nrPDB 197 1e-50 3V1K-A nrPDB 195 4e-50 3KBB-A nrPDB 190 1e-48 5EGN-A nrPDB 186 2e-47 3HSS-A nrPDB 184 8e-47 4IQ4-A nrPDB 175 4e-44 3A2L-A nrPDB 174 8e-44 1HKH-A nrPDB 174 1e-43 1BRO-A nrPDB 171 5e-43 4CCW-A nrPDB 166 2e-41 3HEA-A nrPDB 165 4e-41 1A8S-A nrPDB 163 1e-40 4DGQ-A nrPDB 163 2e-40 2EDA-A nrPDB 163 2e-40 3FOB-A nrPDB 160 1e-39 1A88-A nrPDB 158 5e-39 2XUA-A nrPDB 155 5e-38 1A8Q-A nrPDB 145 7e-35 4G5X-A nrPDB 143 2e-34 4NVR-A nrPDB 142 4e-34 2PSJ-A nrPDB 141 5e-34 4RNC-A nrPDB 135 4e-32 3KXP-A nrPDB 132 5e-31 3OM8-A nrPDB 129 3e-30 3V48-A nrPDB 118 9e-27 4HTA-A nrPDB 117 1e-26 4JB3-A nrPDB 110 2e-24 2WJ4-A nrPDB 93 3e-19 1DWO-A nrPDB 89 5e-18 Sequences not found previously or not previously below threshold: 4CCY-A nrPDB 126 3e-29 1XRN-A nrPDB 111 9e-25 1AZW-A nrPDB 108 6e-24 2XMZ-A nrPDB 106 3e-23 1Q0R-A nrPDB 103 3e-22 5YHP-A nrPDB 101 8e-22 1QTR-A nrPDB 101 1e-21 4IH4-A nrPDB 96 3e-20 1M33-A nrPDB 95 1e-19 3BF8-A nrPDB 94 1e-19 6AP7-A nrPDB 91 9e-19 2OCI-A nrPDB 91 1e-18 4NMW-A nrPDB 88 7e-18 2YYS-A nrPDB 87 2e-17 1SCK-A nrPDB 86 4e-17 3P2M-A nrPDB 83 2e-16 3C5W-P nrPDB 80 3e-15 4QLA-A nrPDB 78 8e-15 3IBT-A nrPDB 76 4e-14 2WFL-A nrPDB 75 8e-14 1Y7H-A nrPDB 74 1e-13 2Y6V-A nrPDB 73 3e-13 6COB-A nrPDB 71 1e-12 3RLI-A nrPDB 70 4e-12 2VAV-A nrPDB 69 4e-12 5OLW-A nrPDB 69 5e-12 4GDM-A nrPDB 68 1e-11 4G9B-A nrPDB 66 3e-11 3L5K-A nrPDB 66 5e-11 2YY6-A nrPDB 66 5e-11 5W8P-A nrPDB 66 6e-11 6EIC-C nrPDB 65 8e-11 5XKS-A nrPDB 65 1e-10 5HK8-A nrPDB 65 1e-10 4FBL-A nrPDB 64 2e-10 1TAH-B nrPDB 64 2e-10 1K8Q-A nrPDB 63 3e-10 1R3D-A nrPDB 63 4e-10 5EFZ-A nrPDB 61 1e-09 3QUB-A nrPDB 61 1e-09 1OIL-A nrPDB 61 1e-09 1HLG-A nrPDB 61 1e-09 1IMJ-A nrPDB 60 3e-09 1TE2-A nrPDB 60 3e-09 3JWE-A nrPDB 59 5e-09 5W8O-A nrPDB 59 5e-09 3NAS-A nrPDB 59 6e-09 4GIB-A nrPDB 58 8e-09 3VVL-A nrPDB 56 3e-08 1R1D-A nrPDB 55 7e-08 3KSR-A nrPDB 53 2e-07 2GFH-A nrPDB 52 9e-07 4ZWN-A nrPDB 51 1e-06 3FCY-A nrPDB 50 2e-06 5JKJ-A nrPDB 49 4e-06 2HI0-A nrPDB 49 4e-06 4KNV-A nrPDB 49 6e-06 3D2A-A nrPDB 46 3e-05 4HXF-B nrPDB 46 4e-05 5D6O-A nrPDB 46 5e-05 3DYV-A nrPDB 45 8e-05 3I1I-A nrPDB 44 1e-04 3FLA-A nrPDB 44 2e-04 4GW3-A nrPDB 43 3e-04 3O4I-A nrPDB 43 3e-04 5V41-A nrPDB 43 4e-04 6FKX-A nrPDB 43 4e-04 5L8S-A nrPDB 43 5e-04 3TEJ-A nrPDB 42 6e-04 2PL5-A nrPDB 42 6e-04 1EX9-A nrPDB 42 6e-04 3E4D-A nrPDB 42 9e-04 3N0T-A nrPDB 41 0.001 3WYD-A nrPDB 41 0.001 4RN3-A nrPDB 41 0.001 4QLO-A nrPDB 41 0.001 2HDO-A nrPDB 41 0.002 3H2H-A nrPDB 40 0.002 2EEP-A nrPDB 40 0.002 2B61-A nrPDB 40 0.002 6HIX-BG nrPDB 40 0.003 3I6Y-A nrPDB 39 0.004 5UNO-A nrPDB 39 0.004 5T6O-A nrPDB 39 0.004 3N2Z-B nrPDB 39 0.005 6CL4-A nrPDB 39 0.006 5DWD-A nrPDB 38 0.008 4Q1V-A nrPDB 38 0.010 6OAZ-A nrPDB 38 0.010 5YP1-A nrPDB 38 0.011 4X97-A nrPDB 38 0.012 1FJ2-A nrPDB 38 0.014 1GPL-A nrPDB 38 0.014 6BJE-A nrPDB 37 0.020 5YAL-A nrPDB 37 0.020 6FVJ-A nrPDB 37 0.022 2HO4-A nrPDB 37 0.024 3HLT-A nrPDB 37 0.029 4PNH-A nrPDB 37 0.029 3FCX-A nrPDB 36 0.031 5I5F-A nrPDB 36 0.031 2B20-A nrPDB 36 0.033 6ECE-A nrPDB 36 0.038 1UFO-A nrPDB 36 0.039 6EOT-A nrPDB 36 0.040 3FNB-A nrPDB 36 0.041 2C4N-A nrPDB 36 0.047 4RAP-A nrPDB 36 0.050 1R88-A nrPDB 36 0.061 1PJA-A nrPDB 36 0.061 2RON-A nrPDB 36 0.062 2PPL-A nrPDB 36 0.065 1BU8-A nrPDB 35 0.078 4B6G-A nrPDB 35 0.089 5BV7-A nrPDB 35 0.10 3LCR-A nrPDB 35 0.11 1PW5-A nrPDB 35 0.11 6BA9-A nrPDB 34 0.17 5I5H-A nrPDB 34 0.18 2X4D-A nrPDB 34 0.20 1DQU-A nrPDB 34 0.23 6EOR-A nrPDB 34 0.23 1ETH-A nrPDB 33 0.32 5KRE-A nrPDB 33 0.33 3QMW-A nrPDB 33 0.39 1WDT-A nrPDB 33 0.43 2PVS-A nrPDB 33 0.47 3LS2-A nrPDB 33 0.49 2ECF-A nrPDB 32 0.67 4GBT-A nrPDB 32 0.67 2BHS-A nrPDB 32 0.68 3PDW-A nrPDB 32 0.82 1W52-X nrPDB 32 0.86 4MQM-A nrPDB 32 0.92 3AZQ-A nrPDB 31 0.98 4R1D-A nrPDB 31 1.0 5LZ5-A nrPDB 31 1.2 6GI5-A nrPDB 31 1.3 1RP1-A nrPDB 31 1.5 3OOQ-A nrPDB 31 1.6 6AVW-A nrPDB 31 1.8 3MGA-A nrPDB 30 2.9 2WAA-A nrPDB 30 3.2 5LV0-A nrPDB 30 3.5 3CUQ-C nrPDB 29 5.6 5LFZ-A nrPDB 29 5.8 3CN7-A nrPDB 29 6.3 >4Y2Y-A nrPDB Length = 561 Score = 801 bits (2069), Expect = 0.0, Method: Composition-based stats. Identities = 555/555 (100%), Positives = 555/555 (100%) Query: 1 MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL 60 MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL Sbjct: 1 MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL 60 Query: 61 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA 120 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA Sbjct: 61 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA 120 Query: 121 ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV 180 ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV Sbjct: 121 ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV 180 Query: 181 VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG 240 VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG Sbjct: 181 VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG 240 Query: 241 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS Sbjct: 241 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 Query: 301 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT Sbjct: 301 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 Query: 361 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH 420 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH Sbjct: 361 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH 420 Query: 421 KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL 480 KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL Sbjct: 421 KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL 480 Query: 481 GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK Sbjct: 481 GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 Query: 541 WLDSDARNPPVVSKM 555 WLDSDARNPPVVSKM Sbjct: 541 WLDSDARNPPVVSKM 555 >1CR6-A nrPDB Length = 554 Score = 753 bits (1944), Expect = 0.0, Method: Composition-based stats. Identities = 406/556 (73%), Positives = 481/556 (86%), Gaps = 3/556 (0%) Query: 1 MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL 60 M LR A FDLDGVLALP++ G R+EEALALPR L A+Q PEG T +LMKG+IT Sbjct: 1 MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITF 60 Query: 61 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA 120 SQW+PLM+E+ RK S+ LP+NFSI +IF +A++AR INRPMLQAA+ L+KKGFTT Sbjct: 61 SQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTC 120 Query: 121 ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV 180 I+TN WLDD +RD LAQ+MCEL HFDFLIESCQVGM+KPEPQIY FLLDTLKA P+EV Sbjct: 121 IVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEV 180 Query: 181 VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG 240 VFLDD G+NLKPARD+GMVTILV +T +AL+ELEKVTG Q APLP CNP+D+SHG Sbjct: 181 VFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQF--PEAPLPVPCNPNDVSHG 238 Query: 241 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 YVTVKP +RLHFVE+GSGPA+CLCHGFPESW+SWRYQIPALAQAG+RVLA+DMKGYG+SS Sbjct: 239 YVTVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSS 298 Query: 301 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 +PPEIEEY ME+LCKEMVTFLDKLG+ QAVFIGHDW G++VW MALFYPERVRAVASLNT Sbjct: 299 SPPEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNT 358 Query: 361 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDE-SVLSM 419 PF+P +P++SP++ I++ PVF+YQLYFQEPGVAEAELE+N+SRTFKS FRASDE +++ Sbjct: 359 PFMPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAV 418 Query: 420 HKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKS 479 HK E GG+ VN+PE+P+LS++ TEEEI+FY+QQFKK+GFRGPLNWYRN ERNWKW+CK Sbjct: 419 HKATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKG 478 Query: 480 LGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILI 539 LGRKIL+PALMVTAEKD VL P+MS++ME WIP LKRGHIEDCGHWTQ++KPTEVNQILI Sbjct: 479 LGRKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILI 538 Query: 540 KWLDSDARNPPVVSKM 555 KWL ++ +NP V SK+ Sbjct: 539 KWLQTEVQNPSVTSKI 554 >5Y6Y-B nrPDB Length = 326 Score = 284 bits (727), Expect = 5e-77, Method: Composition-based stats. Identities = 97/315 (30%), Positives = 168/315 (53%), Gaps = 10/315 (3%) Query: 236 DMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKG 295 ++ H V V +++H E G GP V HGFPE WYSWR+QI AL+ GYR +A D++G Sbjct: 3 EIEHRTVEVN-GIKMHVAEKGEGPVVLFLHGFPELWYSWRHQILALSSRGYRAVAPDLRG 61 Query: 296 YGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 YG++ AP I Y + +++ +D LG+ Q + HDWG ++ WY+ F+P+RV+A Sbjct: 62 YGDTEAPVSISSYTGFHIVGDLIALIDLLGVDQVFLVAHDWGAIIGWYLCTFHPDRVKAY 121 Query: 356 ASLNTPFIPANPNMSPLESIKANPVFDYQL-YFQEPGVAEAELEQNLSRTFKSLFRASDE 414 L+ P + +PN+ +++++A DY + FQ+PG EA++ + + + + Sbjct: 122 VCLSVPLLHRDPNIRTVDAMRAMYGDDYYICRFQKPGEMEAQMAEVGTEYVLKNILTTRK 181 Query: 415 SVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWK 474 + E G F SL +T++++ +YV +++K+GF GPLN+YRNM NW+ Sbjct: 182 PGPPIFPKGEYGTGFNPDMPN-SLPSWLTQDDLAYYVSKYEKTGFTGPLNYYRNMNLNWE 240 Query: 475 WACKSLGRKILIPALMVTAEKDFVLVPQMSQH------MEDWIPHLKRGHIE-DCGHWTQ 527 G KI +P +T E D V + + +P+L+ ++ + H+ Sbjct: 241 LTAPWSGGKIQVPVKFITGELDNVYTSLNMKEYIHGGGFKQDVPNLEEVIVQKNVAHFNN 300 Query: 528 MDKPTEVNQILIKWL 542 + E+N + ++ Sbjct: 301 QEAAEEINNHIYDFI 315 >2E3J-A nrPDB Length = 356 Score = 260 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 105/327 (32%), Positives = 160/327 (48%), Gaps = 42/327 (12%) Query: 257 SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKE 316 GP V L HGFPESWYSWR+QIPALA AGYRV+A+D +GYG SS + Y ++ L + Sbjct: 26 QGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSKYRVQKAYRIKELVGD 85 Query: 317 MVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPF-------IPAN--- 366 +V LD G QA +GHDWG + W A +P+R V ++ PF +P + Sbjct: 86 VVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVPFAGRGVIGLPGSPFG 145 Query: 367 ---PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSL-FRASDESVLSMHKV 422 P+ LE V+ YQ YF E+E++L L + S E +++ K Sbjct: 146 ERRPSDYHLELAGPGRVW-YQDYFAVQDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKA 204 Query: 423 CEAGGLFVNSPEEPSLSR------------------------MVTEEEIQFYVQQFKKSG 458 G+ + S + + R TE ++ FY +F++SG Sbjct: 205 AVDAGVDLESMDPIDVIRAGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSG 264 Query: 459 FRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLV--PQMSQHMEDWIPHLKR 516 F GPL++Y N++ +W G+ + PAL + + D + Q + + +P+ + Sbjct: 265 FGGPLSFYHNIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYRG 324 Query: 517 GH-IEDCGHWTQMDKPTEVNQILIKWL 542 H I D GHW Q + P E N++L+ +L Sbjct: 325 THMIADVGHWIQQEAPEETNRLLLDFL 351 >4NZZ-A nrPDB Length = 320 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 75/316 (23%), Positives = 139/316 (43%), Gaps = 39/316 (12%) Query: 237 MSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGY 296 MS Y+ V V LH++ G G + HGFP+ + WR+QI + + +A+D++GY Sbjct: 34 MSKQYINVN-GVNLHYISKGQGELMLFLHGFPDFSHIWRHQIDEFSN-DFHTVALDLRGY 91 Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVA 356 S P +E Y ++VL +++ ++ LG S + HDWG + W A YPE V+ + Sbjct: 92 NLSEKPSGLESYEIDVLVEDIRQVIEGLGYSSCTLVVHDWGAGIGWTFAYRYPEYVQKLI 151 Query: 357 SLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESV 416 + N P P + +Y +FQ+ V + N S K + Sbjct: 152 AFNGPH-PYTFMRELRTNKNQQKASEYMKWFQKQEVQDYMERDNFSGLRKLVI------- 203 Query: 417 LSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWA 476 + +T +++Q Y+ ++ L++YRN++ + Sbjct: 204 -----------------DPGVKKGYLTADDVQAYMNSWENGSVLSMLSYYRNLKI---FT 243 Query: 477 CKSLGRKIL---------IPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQ 527 + L RK L IP ++ +D +P+ +E+++P++ + + H Q Sbjct: 244 EEDLRRKSLFPLEEEVLNIPVQIIWGNQDPTFMPENLDGIEEYVPNISVHRLAEASHAPQ 303 Query: 528 MDKPTEVNQILIKWLD 543 +KP EVN ++ +L+ Sbjct: 304 HEKPQEVNNVMWNFLN 319 >2B0C-A nrPDB Length = 206 Score = 238 bits (606), Expect = 6e-63, Method: Composition-based stats. Identities = 62/212 (29%), Positives = 96/212 (45%), Gaps = 20/212 (9%) Query: 7 VFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPL 66 +FDL V+ VLG + +P L +F G A + +GEI+ + Sbjct: 11 IFDLGNVIVDIDFNRVLGAWSDLTRIPLASLKKSFHMGE---AFHQHERGEISDEAFAEA 67 Query: 67 MEENCRKCSETAKVCLPKNFSIKEIFDKAISARKIN-RPMLQAALM-LRKKGFTTAILTN 124 + C E A LP ++ E F A + RP + A + LR++G +L+N Sbjct: 68 L------CHEMA---LPLSY---EQFSHGWQAVFVALRPEVIAIMHKLREQGHRVVVLSN 115 Query: 125 TWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLD 184 T +R + E++ D + S +GM KPE +IY+ +L SPS+ VF D Sbjct: 116 T---NRLHTTFWPEEYPEIRDAADHIYLSQDLGMRKPEARIYQHVLQAEGFSPSDTVFFD 172 Query: 185 DIGANLKPARDLGMVTILVQDTDTALKELEKV 216 D N++ A LG+ +ILV+D T KV Sbjct: 173 DNADNIEGANQLGITSILVKDKTTIPDYFAKV 204 >5UXZ-A nrPDB Length = 307 Score = 227 bits (579), Expect = 8e-60, Method: Composition-based stats. Identities = 76/328 (23%), Positives = 129/328 (39%), Gaps = 54/328 (16%) Query: 228 LPTSCNPSDMSHGYVTVKPRVRLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAG 285 P + ++ R+H+V++G G V HG P S Y WR IP +A Sbjct: 5 FPFDPHYVEVL--------GERMHYVDVGPRDGTPVLFLHGNPTSSYVWRNIIPHVAPT- 55 Query: 286 YRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMA 345 +R +A D+ G G+S P Y + + M F++ LGL + V + HDWG L ++ A Sbjct: 56 HRCIAPDLIGMGKSDKPDL--GYFFDDHVRFMDAFIEALGLEEVVLVIHDWGSALGFHWA 113 Query: 346 LFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTF 405 PERV+ +A + E I+ P +D E + TF Sbjct: 114 KRNPERVKGIAFM--------------EFIRPIPTWD-------------EWPEFARETF 146 Query: 406 KSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNW 465 ++ FR +D K+ +F+ + R +TE E+ Y + F R PL Sbjct: 147 QA-FRTTDVG----RKLIIDQNVFIEGTLPMGVVRPLTEVEMDHYREPFLNPVDREPLWR 201 Query: 466 YRN-MERNWKWA--------CKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKR 516 + N + + A + +P L+ ++ P + + +P+ K Sbjct: 202 FPNELPIAGEPANIVALVEEYMDWLHQSPVPKLLFWGTPGVLIPPAEAARLAKSLPNCKA 261 Query: 517 GHIEDCGHWTQMDKPTEVNQILIKWLDS 544 I + Q D P + + +WL + Sbjct: 262 VDIGPGLNLLQEDNPDLIGSEIARWLST 289 >3WMR-A nrPDB Length = 315 Score = 210 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 120/295 (40%), Gaps = 26/295 (8%) Query: 254 ELGSG-PAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE--YCM 310 +L SG P V L HG P S + + + +L +AG+ V+ D G G S+ PE E + + Sbjct: 41 DLHSGKPPVVLLHGGPGSTHDYLLAMTSLTEAGWPVVHYDQLGNGGSTHLPEKGEDFWTV 100 Query: 311 EVLCKEMVTFLDKLGL-SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM 369 ++ E+ L++LG+ V G WGGML A P +R + N P + + Sbjct: 101 QLFEDELDNLLNQLGIAGDYVLFGQSWGGMLGSVHAARRPAGLRGLVVANAPA---SMKI 157 Query: 370 SPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLF 429 E + + P V E L+ +RT + VC Sbjct: 158 WLQEMARLRALL-------PPDVQETLLKHEAARTTDTEEYFHAMRAFYDRHVCR----I 206 Query: 430 VNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPAL 489 V P + + + M + Y + GP N + + W+ + I +P + Sbjct: 207 VPWPRDFAATFM------EIYNDPTVYTTMNGP-NEFHVIGTLRDWSVEDCLPDIQVPTM 259 Query: 490 MVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDS 544 ++ D P + D +P ++ +E+ H +++P ++++I +L+S Sbjct: 260 VLIGRHDEA-TPATVKPFLDLVPDVRYEVLENSSHVPHLEEPERFHEVMIDYLES 313 >2O2H-A nrPDB Length = 300 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 119/309 (38%), Gaps = 49/309 (15%) Query: 247 RVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSA--PPE 304 R+ +++ G G A+ HG P S Y WR +P L G R++A D+ G G S P Sbjct: 19 GKRMAYIDEGKGDAIVFQHGNPTSSYLWRNIMPHLEGLG-RLVACDLIGMGASDKLSPSG 77 Query: 305 IEEYCMEVLCKEMVTFLDKLGLS-QAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFI 363 + Y + D L L V + HDWG L + A + +RV+ +A + Sbjct: 78 PDRYSYGEQRDFLFALWDALDLGDHVVLVLHDWGSALGFDWANQHRDRVQGIAFMEAIVT 137 Query: 364 PANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVC 423 P + A+ + F+ E + H + Sbjct: 138 P---------------------------MTWADWPPAVRGVFQGFRSPQGEPMALEHNI- 169 Query: 424 EAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSG--FRGPLNWYRNMERNWKWA----- 476 FV ++ R +++EE+ Y + F G R L+W RN+ + + A Sbjct: 170 -----FVERVLPGAILRQLSDEEMNHYRRPFVNGGEDRRPTLSWPRNLPIDGEPAEVVAL 224 Query: 477 ---CKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTE 533 +S + +P L + AE ++ ++ ++ W P+ + H+ Q D P E Sbjct: 225 VNEYRSWLEETDMPKLFINAEPGAIITGRIRDYVRSW-PNQTEITVPGV-HFVQEDSPEE 282 Query: 534 VNQILIKWL 542 + + +++ Sbjct: 283 IGAAIAQFV 291 >3NWO-A nrPDB Length = 330 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 112/292 (38%), Gaps = 31/292 (10%) Query: 258 GPAVCLCHGFPESWYSWRYQIPALAQ-AGYRVLAMDMKGYGESSAPPE--IEEYCMEVLC 314 + + HG P +++ I ALA G V+ D G G S+ P+ + + ++ Sbjct: 54 ALPLIVLHGGPGMAHNYVANIAALADETGRTVIHYDQVGCGNSTHLPDAPADFWTPQLFV 113 Query: 315 KEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLES 374 E LG+ + +G WGGML +A+ P + ++A N+P S Sbjct: 114 DEFHAVCTALGIERYHVLGQSWGGMLGAEIAVRQPSGLVSLAICNSPA-----------S 162 Query: 375 IKANPVFDYQLYFQEPGVAEAELEQNLSR---TFKSLFRASDESVLSMHKVCEAGGLFVN 431 ++ L Q P A L+++ + T +A+ E VC V Sbjct: 163 MRLWSEAAGDLRAQLPAETRAALDRHEAAGTITHPDYLQAAAE--FYRRHVCR----VVP 216 Query: 432 SPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMV 491 +P++ + S E E Y GP N + + W+ + P L++ Sbjct: 217 TPQDFADSVAQMEAEPTVY------HTMNGP-NEFHVVGTLGDWSVIDRLPDVTAPVLVI 269 Query: 492 TAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLD 543 E D P+ Q D IP ++ H T ++KP E ++ ++L Sbjct: 270 AGEHDEA-TPKTWQPFVDHIPDVRSHVFPGTSHCTHLEKPEEFRAVVAQFLH 320 >1U2E-A nrPDB Length = 289 Score = 202 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 117/303 (38%), Gaps = 41/303 (13%) Query: 245 KPRVRLHFVELGSGP-AVCLCHG---FPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 +R+HF + G G V L HG W ++ I L +AGYRV+ +D G+G+S Sbjct: 22 GKTLRIHFNDCGQGDETVVLLHGSGPGATGWANFSRNIDPLVEAGYRVILLDCPGWGKSD 81 Query: 301 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 + ++ + + + +D+L +++ +G+ GG L +PERV + + Sbjct: 82 SVVNSGSRS-DLNARILKSVVDQLDIAKIHLLGNSMGGHSSVAFTLKWPERVGKLVLMGG 140 Query: 361 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH 420 MS + + +++P + +L ++ +F SD Sbjct: 141 ----GTGGMSLFTPMPTEGIKRLNQLYRQPTIENLKLMMDI-----FVFDTSD------- 184 Query: 421 KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL 480 ++ E L+ M++ + +++ F KS P + R + ++ Sbjct: 185 --------LTDALFEARLNNMLSRRD---HLENFVKSLEANPKQFPDFGPRLAEIKAQT- 232 Query: 481 GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 L+V D + + I + DCGHW Q + NQ+++ Sbjct: 233 --------LIVWGRNDRFVPMDAGLRLLSGIAGSELHIFRDCGHWAQWEHADAFNQLVLN 284 Query: 541 WLD 543 +L Sbjct: 285 FLA 287 >2WUG-A nrPDB Length = 291 Score = 197 bits (501), Expect = 9e-51, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 119/307 (38%), Gaps = 43/307 (14%) Query: 242 VTVKPRVRLHFVELGSG--PAVCLCHGFPE---SWYSWRYQIPALAQAGYRVLAMDMKGY 296 V V ++LH+ E G G V L HG SW ++ I LA+ + VLA+D GY Sbjct: 18 VDVDGPLKLHYHEAGVGNDQTVVLLHGGGPGAASWTNFSRNIAVLARH-FHVLAVDQPGY 76 Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVA 356 G S E ++ + D+LGL + +G+ GG AL YP R + Sbjct: 77 GHSDKRAEHGQFN-RYAAMALKGLFDQLGLGRVPLVGNALGGGTAVRFALDYPARAGRLV 135 Query: 357 SLNTPFIPAN-PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDES 415 + + N P E +K F A +NL + D++ Sbjct: 136 LMGPGGLSINLFAPDPTEGVKRLSKFSV-----------APTRENLEAFLR--VMVYDKN 182 Query: 416 VLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKW 475 +++ V + L ++PE + +R + + F + F + W R + R Sbjct: 183 LITPELVDQRFAL-ASTPESLTATRAMG--------KSFAGADFEAGMMW-REVYRL--- 229 Query: 476 ACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVN 535 P L++ +D V + IP + CGHW Q++K E N Sbjct: 230 ---------RQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFN 280 Query: 536 QILIKWL 542 ++ I++L Sbjct: 281 KLTIEFL 287 >4UHD-A nrPDB Length = 282 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 119/303 (39%), Gaps = 44/303 (14%) Query: 241 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 + L F + G+G V L HGFP W+ Q L +RV+ D++G+GES Sbjct: 9 TTATPGEIELAFEDTGTGLPVLLVHGFPLDRTMWKAQREELCDE-FRVIVPDLRGFGESQ 67 Query: 301 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIG-HDWGGMLVWYMALFYPERVRAVASLN 359 P + ME + ++ + LGL+ + +G GG + + A Y +R+ + + Sbjct: 68 VIPGVA--TMEAMADDLAGLCNHLGLTGKIVLGGLSMGGYVAFAFARKYRDRLAGLILCD 125 Query: 360 TPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSM 419 T P +P E+ + ++ + PG E+ L +S FR E + + Sbjct: 126 TRARPDSP-----EAKENRRRVAERVRREGPGFIAEEMIPRLC--CESTFRNHPEVIEKI 178 Query: 420 HKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKS 479 + + +++P E + + G + + +C Sbjct: 179 RQ------MILSAPPEGVAAAAL------------------GMAERPDSTDLLPALSC-- 212 Query: 480 LGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILI 539 P L++ + D + P+ + M IP + I D GH M++P V Q + Sbjct: 213 -------PTLVLVGQFDAISPPEEMEAMARTIPQSQFVVIPDAGHLPPMEQPERVTQAIR 265 Query: 540 KWL 542 +WL Sbjct: 266 EWL 268 >3V1K-A nrPDB Length = 286 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 111/300 (37%), Gaps = 46/300 (15%) Query: 249 RLHFVELGSGPAVCLCHGFPES---WYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEI 305 +H+ E G+G V + HG W ++ + AGYRV+ D G+ +S A Sbjct: 24 NIHYNEAGNGETVIMLHGGGPGAGGWSNYYRNVGPFVDAGYRVILKDSPGFNKSDAVVMD 83 Query: 306 EEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFI-P 364 E+ + V + + +D L + +A +G+ GG AL YP+R+ + + + P Sbjct: 84 EQRGL-VNARAVKGLMDALDIDRAHLVGNSMGGATALNFALEYPDRIGKLILMGPGGLGP 142 Query: 365 ANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRA--SDESVLSMHKV 422 + P+E IK + EP T K + + D+S+++ Sbjct: 143 SMFAPMPMEGIKLL-----FKLYAEPSY----------ETLKQMLQVFLYDQSLIT---- 183 Query: 423 CEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGR 482 EE R + +++ F S + PL+ + R + K+ Sbjct: 184 -----------EELLQGRWEAIQRQPEHLKNFLISAQKAPLSTWDVTARLGEIKAKTF-- 230 Query: 483 KILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWL 542 + D + + I + CG W Q + E N+++I +L Sbjct: 231 -------ITWGRDDRFVPLDHGLKLLWNIDDARLHVFSKCGQWAQWEHADEFNRLVIDFL 283 >3KBB-A nrPDB Length = 216 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 51/204 (25%), Positives = 91/204 (44%), Gaps = 28/204 (13%) Query: 3 LRAAVFDLDGVL--ALPAVFGVLGRTEEALALPRGLLNDAFQK--GGPEGATTRLMKGEI 58 + A +FD+DGVL P F R E+ P D ++ G PE ++ + Sbjct: 1 MEAVIFDMDGVLMDTEPLYFEAYRRVAESYGKP--YTEDLHRRIMGVPEREGLPILMEAL 58 Query: 59 TLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFT 118 + + EN +K K K +F + + K N + +A ++ K Sbjct: 59 EIKDSL----ENFKKRVHEEK---------KRVFSELL---KENPGVREALEFVKSKRIK 102 Query: 119 TAILTNTWLDDRAERDGLAQLM-CELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASP 177 A+ T+T +R+ L +L +L+ +FD ++ QV KP+P+IY +L+ L P Sbjct: 103 LALATST-----PQREALERLRRLDLEKYFDVMVFGDQVKNGKPDPEIYLLVLERLNVVP 157 Query: 178 SEVVFLDDIGANLKPARDLGMVTI 201 +VV +D + ++ A+ G+ I Sbjct: 158 EKVVVFEDSKSGVEAAKSAGIERI 181 >5EGN-A nrPDB Length = 271 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 113/300 (37%), Gaps = 43/300 (14%) Query: 245 KPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPE 304 V++++ G G + H F + W +Q AQ + V+ +D +G+G S P Sbjct: 6 NDGVKIYYDSYGEGVPIVFLHPFSTNGGIWYFQTFPFAQTNH-VIVIDHRGHGRSDKPAT 64 Query: 305 IEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIP 364 Y + ++V LD L + +AVF+G+ GGM+ + L +P+RV L++ Sbjct: 65 --GYSIMEHADDVVAVLDALKVDRAVFVGNSIGGMIAMQLNLDHPQRVIGNLILSSGTGL 122 Query: 365 ANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCE 424 P A A + + F L E +S E Sbjct: 123 GEGM---------------------PPEAGAAFQNDYIGAFGGLL----EGAVSARSKRE 157 Query: 425 AGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKI 484 + S+ F K F + + W K I Sbjct: 158 RPEILAVMKAHFSVP------------SNFPKHVFDAATADPNGV---FAWNIKDRLSSI 202 Query: 485 LIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDS 544 P L+V E+D V +Q + D IP + I D GH+ Q+++P+E N++L ++ + Sbjct: 203 QAPTLVVAGEEDLVTTVANNQLLADNIPGAELRVINDVGHFYQLERPSEFNELLRGFVAA 262 >3HSS-A nrPDB Length = 293 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 107/302 (35%), Gaps = 49/302 (16%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWR-YQIPALAQAGYRVLAMDMKGYGESSAPPEIE 306 + L + + G+G V G + +W +Q+PA AGYR + D +G G + E Sbjct: 33 INLAYDDNGTGDPVVFIAGRGGAGRTWHPHQVPAFLAAGYRCITFDNRGIGATE---NAE 89 Query: 307 EYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPAN 366 + + + + ++ L ++ A +G G + + + PE V + + T Sbjct: 90 GFTTQTMVADTAALIETLDIAPARVVGVSMGAFIAQELMVVAPELVSSAVLMATRGRLDR 149 Query: 367 PNMSPLESIKANPVFDYQLYFQEPGV--AEAELEQNLSR-TFKSLFRASD-ESVLSMHKV 422 + Y Q P A A L +N SR T D ++ SM + Sbjct: 150 A----RQFFNKAEAELYDSGVQLPPTYDARARLLENFSRKTLNDDVAVGDWIAMFSMWPI 205 Query: 423 CEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGR 482 GL P +R L YRN Sbjct: 206 KSTPGLRCQLDCAPQTNR----------------------LPAYRN-------------- 229 Query: 483 KILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWL 542 I P L++ D V P + + + D +P+ + I D GH ++P VN ++K+ Sbjct: 230 -IAAPVLVIGFADDVVTPPYLGREVADALPNGRYLQIPDAGHLGFFERPEAVNTAMLKFF 288 Query: 543 DS 544 S Sbjct: 289 AS 290 >4IQ4-A nrPDB Length = 456 Score = 175 bits (444), Expect = 4e-44, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 114/298 (38%), Gaps = 36/298 (12%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 + L++ + G+G V L HGFP S +SW Q AL AGYRV+ D +G+G+SS P + Sbjct: 14 IDLYYEDHGTGTPVVLIHGFPLSGHSWERQSAALLDAGYRVITYDRRGFGQSSQPTTGYD 73 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWG-GMLVWYMALFYPERVRAVASLNTPFIPAN 366 Y + ++ T L+ L L AV +G G G + Y++ + R+ AVA L + Sbjct: 74 Y--DTFAADLNTVLETLDLQDAVLVGFSMGTGEVARYVSSYGTARIAAVAFLASLEPFLL 131 Query: 367 PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAG 426 + FD + +A+ + F F DE++ + Sbjct: 132 KTDDNPDGAAPQEFFDGIV-----AAVKADRYAFYTGFFND-FYNLDENLGTRI------ 179 Query: 427 GLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILI 486 EE + T + P WY + + +I + Sbjct: 180 ------SEEAVRNSWNTAASGG------FFAAAAAPTTWYTDFRAD--------IPRIDV 219 Query: 487 PALMVTAEKDFVLVPQMSQH-MEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLD 543 PAL++ D L + + +P + +E H EVN L+ +L Sbjct: 220 PALILHGTGDRTLPIENTARVFHKALPSAEYVEVEGAPHGLLWTHAEEVNTALLAFLA 277 >3A2L-A nrPDB Length = 309 Score = 174 bits (441), Expect = 8e-44, Method: Composition-based stats. Identities = 62/319 (19%), Positives = 114/319 (35%), Gaps = 43/319 (13%) Query: 247 RVRLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPE 304 + + E G P V HG P S + WR +P ++ + +A D+ G+G+S P Sbjct: 16 GSSMAYRETGAQDAPVVLFLHGNPTSSHIWRNILPLVSPVAH-CIAPDLIGFGQSGKPDI 74 Query: 305 IEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIP 364 Y + + F+++ G++ A + DWG L +++A P+ VR +A + FI Sbjct: 75 A--YRFFDHVRYLDAFIEQRGVTSAYLVAQDWGTALAFHLAARRPDFVRGLAFME--FIR 130 Query: 365 ANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCE 424 P A F+ PG EA + + Sbjct: 131 PMPTWQDFHQDHAEAARAVFRKFRTPGEGEAMILE------------------------- 165 Query: 425 AGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGP-LNWYRNMERNWKWA------- 476 FV + R + +EE+ Y F R P L + R + + A Sbjct: 166 -ANAFVERVLPGGIVRKLGDEEMAPYRTPFPTPESRRPVLAFPRELPIAGEPADVYEALQ 224 Query: 477 -CKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVN 535 + P L+ T E ++ P+ ++ + + H+ Q D + Sbjct: 225 SAHAALAASSYPKLLFTGEPGALVSPEFAERFAASLTRCALIRLGAGLHYLQEDHADAIG 284 Query: 536 QILIKWLDS-DARNPPVVS 553 + + W+ +A P + + Sbjct: 285 RSVAGWIAGIEAVRPQLAA 303 >1HKH-A nrPDB Length = 279 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 72/317 (22%), Positives = 112/317 (35%), Gaps = 52/317 (16%) Query: 240 GYVTVKP----RVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKG 295 GY+TV + L++ + GSG V L HG+P +SW Q L GYRV+ D +G Sbjct: 1 GYITVGNENSTPIELYYEDQGSGQPVVLIHGYPLDGHSWERQTRELLAQGYRVITYDRRG 60 Query: 296 YGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWG-GMLVWYMALFYPERVRA 354 +G SS +Y + ++ T L+ L L V +G G G L Y+A + ERV Sbjct: 61 FGGSSKVNTGYDY--DTFAADLHTVLETLDLRDVVLVGFSMGTGELARYVARYGHERVAK 118 Query: 355 VASLNT--PFI---PANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLF 409 +A L + PF+ NP P E EA + + F + Sbjct: 119 LAFLASLEPFLVQRDDNPEGVPQEVF---------------DGIEAAAKGDRFAWFTDFY 163 Query: 410 RASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNM 469 + F N E + Q + + P+ Y + Sbjct: 164 KN-----------------FYNLDENLG-----SRISEQAVTGSWNVAIGSAPVAAYAVV 201 Query: 470 ERNWKWACKSL--GRKILIPALMVTAEKDFVLVPQ-MSQHMEDWIPHLKRGHIEDCGHWT 526 + + R P L++ KD +L ++ +P +E H Sbjct: 202 PAWIEDFRSDVEAVRAAGKPTLILHGTKDNILPIDATARRFHQAVPEADYVEVEGAPHGL 261 Query: 527 QMDKPTEVNQILIKWLD 543 EVN L +L Sbjct: 262 LWTHADEVNAALKTFLA 278 >1BRO-A nrPDB Length = 277 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 114/298 (38%), Gaps = 36/298 (12%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 + L++ + G+G V L HGFP S +SW Q AL AGYRV+ D +G+G+SS P + Sbjct: 13 IDLYYEDHGTGQPVVLIHGFPLSGHSWERQSAALLDAGYRVITYDRRGFGQSSQPTTGYD 72 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWG-GMLVWYMALFYPERVRAVASLNTPFIPAN 366 Y + ++ T L+ L L AV +G G G + Y++ + R+ VA L + Sbjct: 73 Y--DTFAADLNTVLETLDLQDAVLVGFSMGTGEVARYVSSYGTARIAKVAFLASLEPFLL 130 Query: 367 PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAG 426 + FD + +A+ + F F DE++ + Sbjct: 131 KTDDNPDGAAPQEFFDGIV-----AAVKADRYAFYTGFFND-FYNLDENLGTRI------ 178 Query: 427 GLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILI 486 EE + T F + P WY + + +I + Sbjct: 179 ------SEEAVRNSWNTAASGGF------FAAAAAPTTWYTDFRAD--------IPRIDV 218 Query: 487 PALMVTAEKDFVLVPQMSQH-MEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLD 543 PAL++ D L + + +P + +E H EVN L+ +L Sbjct: 219 PALILHGTGDRTLPIENTARVFHKALPSAEYVEVEGAPHGLLWTHAEEVNTALLAFLA 276 >4CCW-A nrPDB Length = 299 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 65/317 (20%), Positives = 124/317 (39%), Gaps = 68/317 (21%) Query: 241 YVTVKPRVRLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGE 298 Y++ + + H + G P + L HG S W I A + YR A+D+ G Sbjct: 36 YISTRFG-QTHVIASGPEDAPPLVLLHGALFSSTMWYPNI-ADWSSKYRTYAVDIIGDKN 93 Query: 299 SSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASL 358 S P + + ++ D LG+ ++ IG GG+ L PERV++ A L Sbjct: 94 KSIPENLSGTRTD-YANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAIL 152 Query: 359 NTPFIPANPNMSPLESIKANPVFDYQLYFQEPGV-AEAELEQNLSRTFKSLFRASDESVL 417 SP E+ F + Y G+ A +E+ L+ + +D++VL Sbjct: 153 -----------SPAETFLP---FHHDFYKYALGLTASNGVEKFLN------WMMTDQNVL 192 Query: 418 SM--HKVCEAGGLFVNSPEEPS-----LSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNME 470 K +AG ++ + P+ + T+EE+ Sbjct: 193 HPIFVKQFQAGVMWQDGSRNPNPKADGFPYVFTDEEL----------------------- 229 Query: 471 RNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQH-MEDWIPHLKRGHIEDCGHWTQMD 529 R +P L++ E + + P + H ++P ++ I++ GH M+ Sbjct: 230 -----------RSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVLSME 278 Query: 530 KPTEVNQILIKWLDSDA 546 +P VN+ ++++ +++ Sbjct: 279 QPAYVNERVMRFFNAET 295 >3HEA-A nrPDB Length = 271 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 56/305 (18%), Positives = 108/305 (35%), Gaps = 48/305 (15%) Query: 245 KPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPE 304 K +++F + GSG V HG+P W YQ+ L+ GYR +A D +G+G S P Sbjct: 6 KDGTQIYFKDWGSGKPVLFSHGWPLDADMWEYQMEYLSSRGYRTIAFDRRGFGRSDQPWT 65 Query: 305 IEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGM-LVWYMALFYPERVRAVASLNTPFI 363 +Y + ++ ++ L L + +G GG + Y+A RV + L Sbjct: 66 GNDY--DTFADDIAQLIEHLDLKEVTLVGFSMGGGDVARYIARHGSARVAGLVLLGAVTP 123 Query: 364 -----PANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLS 418 P P PL+ EL ++ ++ + Sbjct: 124 IFGQKPDYPQGVPLDVFARFK---------------TELLKDRAQFISDF----NAPFYG 164 Query: 419 MHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACK 478 ++K + +L + V F ++ FR + Sbjct: 165 INKGQVVSQGVQTQTLQIALLASLKA--TVDCVTAFAETDFRPDM--------------- 207 Query: 479 SLGRKILIPALMVTAEKDFVLVPQ-MSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQI 537 KI +P L++ + D ++ + + + I + +D H + ++N+ Sbjct: 208 ---AKIDVPTLVIHGDGDQIVPFETTGKVAAELIKGAELKVYKDAPHGFAVTHAQQLNED 264 Query: 538 LIKWL 542 L+ +L Sbjct: 265 LLAFL 269 >1A8S-A nrPDB Length = 273 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 113/309 (36%), Gaps = 46/309 (14%) Query: 241 YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS 300 T + ++++ + GSG + HG+P + SW Q+ LA GYRV+A D +G+G SS Sbjct: 2 TFTTRDGTQIYYKDWGSGQPIVFSHGWPLNADSWESQMIFLAAQGYRVIAHDRRGHGRSS 61 Query: 301 APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGM-LVWYMALFYPERV--RAVAS 357 P + M+ ++ ++ L L AV G GG + Y+ RV + S Sbjct: 62 QPWSGND--MDTYADDLAQLIEHLDLRDAVLFGFSTGGGEVARYIGRHGTARVAKAGLIS 119 Query: 358 LNTPFI---PANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDE 414 P + ANP P+E G+ +A L + S+ +K L AS Sbjct: 120 AVPPLMLKTEANPGGLPMEVFD--------------GIRQASLA-DRSQLYKDL--ASGP 162 Query: 415 SVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWK 474 ++ V+ + + G N Y ++ + Sbjct: 163 FFGFNQPGAKSSAGMVDW--------------------FWLQGMAAGHKNAYDCIKAFSE 202 Query: 475 WACKSLGRKILIPALMVTAEKDFVLVPQMSQHM-EDWIPHLKRGHIEDCGHWTQMDKPTE 533 +KI +P L+V + D V+ + S + H + Sbjct: 203 TDFTEDLKKIDVPTLVVHGDADQVVPIEASGIASAALVKGSTLKIYSGAPHGLTDTHKDQ 262 Query: 534 VNQILIKWL 542 +N L+ ++ Sbjct: 263 LNADLLAFI 271 >4DGQ-A nrPDB Length = 280 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 109/310 (35%), Gaps = 36/310 (11%) Query: 238 SHGYVTVKPRVRLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKG 295 S G VT K V + + + G + HG+P S W Q+ G+RV+A D +G Sbjct: 4 SMGTVTTKDGVEIFYKDWGPRDAKVIHFHHGWPLSSDDWDAQLLFFVNKGFRVVAHDRRG 63 Query: 296 YGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 +G SS + + M+ + ++KLG A+ +GH GG V + ER + Sbjct: 64 HGRSSQVWDGHD--MDHYADDAAAVVEKLGTHGAMHVGHSTGGGEVVRYIARHGERNVSK 121 Query: 356 ASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDES 415 A L + P S + VFD +A + N ++ + Sbjct: 122 AVLISSVPPLMVKTSSNPNGTPKSVFDDF---------QAHVAANRAQFYLD-------- 164 Query: 416 VLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKW 475 V + +R + +++ Y + + Sbjct: 165 --------------VPAGPFYGYNRPGAKPSEGVIYNWWRQGMMGSTKAQYDGIVAFSQT 210 Query: 476 ACKSLGRKILIPALMVTAEKDFVLVPQMSQHM-EDWIPHLKRGHIEDCGHWTQMDKPTEV 534 + + I IP L++ + D V+ S + + + K + H +V Sbjct: 211 DFTNDLKGITIPVLVIHGDDDQVVPYADSGVLSAKLVKNGKLITYKGAPHGIPTTHADKV 270 Query: 535 NQILIKWLDS 544 N L+++L S Sbjct: 271 NADLLEFLQS 280 >2EDA-A nrPDB Length = 310 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 68/329 (20%), Positives = 117/329 (35%), Gaps = 49/329 (14%) Query: 229 PTSCNPSDMSHGYVTVKPRVRLHFVELGSGPA--VCLC-HGFPESWYSWRYQIPALAQAG 285 P S N D GY P +R H+++ G+ A V LC HG P Y +R IP A++G Sbjct: 19 PFSPNYLDDLPGY----PGLRAHYLDEGNSDAEDVFLCLHGEPTWSYLYRKMIPVFAESG 74 Query: 286 YRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMA 345 RV+A D G+G+S P + E+Y E ++ +++L L + DWGG L + Sbjct: 75 ARVIAPDFFGFGKSDKPVDEEDYTFEFHRNFLLALIERLDLRNITLVVQDWGGFLGLTLP 134 Query: 346 LFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTF 405 + P R + + +N + + P + + Sbjct: 135 MADPSRFKRLIIMNACLMTDPVTQPAFSAFVTQPADGFTAWK------------------ 176 Query: 406 KSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNW 465 D S ++ + + + +TE E Y F + ++ + Sbjct: 177 ------YDLVTPSDLRLDQFMKRWAPT---------LTEAEASAYAAPFPDTSYQAGVRK 221 Query: 466 YRNMERNWKWACKS--------LGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHL-KR 516 + M AC M KD +L P + M+ I + Sbjct: 222 FPKMVAQRDQACIDISTEAISFWQNDWNGQTFMAIGMKDKLLGPDVMYPMKALINGCPEP 281 Query: 517 GHIEDCGHWTQMDKPTEVNQILIKWLDSD 545 I D GH+ Q + L + +++ Sbjct: 282 LEIADAGHFVQEFGEQVAREALKHFAETE 310 >3FOB-A nrPDB Length = 281 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 109/298 (36%), Gaps = 36/298 (12%) Query: 247 RVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIE 306 + +++ + G+G V L HG+P S SW YQ+PAL +AGYRV+ D +G+G+SS P E Sbjct: 16 PIEIYYEDHGTGKPVVLIHGWPLSGRSWEYQVPALVEAGYRVITYDRRGFGKSSQPW--E 73 Query: 307 EYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGM-LVWYMALFYPERVRAVASLNTPFIPA 365 Y + ++ L++L L +G GG + Y++ + +R+ V Sbjct: 74 GYEYDTFTSDLHQLLEQLELQNVTLVGFSMGGGEVARYISTYGTDRIEKVVFAGAVPPYL 133 Query: 366 NPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEA 425 + E + +A +E S DE + Sbjct: 134 YKSEDHPEG----------------ALDDATIETFKSGVINDRLAFLDEFTKGFFAAGDR 177 Query: 426 GGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKIL 485 L S F + + + P + K + K Sbjct: 178 TDLVSES----------------FRLYNWDIAAGASPKGTLDCITAFSKTDFRKDLEKFN 221 Query: 486 IPALMVTAEKDFVLVPQ-MSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWL 542 IP L++ + D + + + + IP+ K I+ H E N+ L+ +L Sbjct: 222 IPTLIIHGDSDATVPFEYSGKLTHEAIPNSKVALIKGGPHGLNATHAKEFNEALLLFL 279 >1A88-A nrPDB Length = 275 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 100/314 (31%), Gaps = 48/314 (15%) Query: 240 GYVTVKPRVRLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYG 297 G VT + + + G G V HG+P S W Q+ GYRV+A D +G+G Sbjct: 1 GTVTTSDGTNIFYKDWGPRDGLPVVFHHGWPLSADDWDNQMLFFLSHGYRVIAHDRRGHG 60 Query: 298 ESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGM-LVWYMALFYPERVRAVA 356 S P + M+ ++ + L L AV IGH GG + Y+A P RV Sbjct: 61 RSDQPSTGHD--MDTYAADVAALTEALDLRGAVHIGHSTGGGEVARYVARAEPGRVAKAV 118 Query: 357 SLNTPFI-----PANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRA 411 ++ NP+ PLE A L N ++ + Sbjct: 119 LVSAVPPVMVKSDTNPDGLPLEVF---------------DEFRAALAANRAQFY------ 157 Query: 412 SDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMER 471 + V S +R + + Y + Sbjct: 158 ----------------IDVPSGPFYGFNREGATVSQGLIDHWWLQGMMGAANAHYECIAA 201 Query: 472 NWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHM-EDWIPHLKRGHIEDCGHWTQMDK 530 + ++I +P L+ D V+ + + + + E H Sbjct: 202 FSETDFTDDLKRIDVPVLVAHGTDDQVVPYADAAPKSAELLANATLKSYEGLPHGMLSTH 261 Query: 531 PTEVNQILIKWLDS 544 P +N L+ ++ S Sbjct: 262 PEVLNPDLLAFVKS 275 >2XUA-A nrPDB Length = 266 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 60/309 (19%), Positives = 111/309 (35%), Gaps = 52/309 (16%) Query: 238 SHGYVTVKPRVRLHF----VELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDM 293 SH LH+ G+ P + L + W Q+ AL++ +RVL D Sbjct: 2 SHMPYAAVNGTELHYRIDGERHGNAPWIVLSNSLGTDLSMWAPQVAALSKH-FRVLRYDT 60 Query: 294 KGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVR 353 +G+G S AP Y +E L +++ +D L +++A F G GG+ +A + +R+ Sbjct: 61 RGHGHSEAPKG--PYTIEQLTGDVLGLMDTLKIARANFCGLSMGGLTGVALAARHADRIE 118 Query: 354 AVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASD 413 VA NT +P + ++KA A + L R F + + Sbjct: 119 RVALCNTAARIGSPEVWVPRAVKART-----------EGMHALADAVLPRWFTADYM--- 164 Query: 414 ESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNW 473 EP + M+ F + G + N E Sbjct: 165 -------------------EREPVVLAMI--------RDVFVHTDKEG---YASNCEAID 194 Query: 474 KWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTE 533 + I +PAL+++ D P + + I + + D H + +++ Sbjct: 195 AADLRPEAPGIKVPALVISGTHDLAATPAQGRELAQAIAGARYVEL-DASHISNIERADA 253 Query: 534 VNQILIKWL 542 + ++ +L Sbjct: 254 FTKTVVDFL 262 >1A8Q-A nrPDB Length = 274 Score = 145 bits (364), Expect = 7e-35, Method: Composition-based stats. Identities = 64/313 (20%), Positives = 109/313 (34%), Gaps = 55/313 (17%) Query: 243 TVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAP 302 T + V + + + G G V HG+P + +W+ Q+ A+ AGYR +A D +G+G S+ Sbjct: 4 TTRDGVEIFYKDWGQGRPVVFIHGWPLNGDAWQDQLKAVVDAGYRGIAHDRRGHGHST-- 61 Query: 303 PEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGM-LVWYMALFYPERVRAVASLNTP 361 P + Y + ++ L L L + H GG L Y+ R+R+ L+ Sbjct: 62 PVWDGYDFDTFADDLNDLLTDLDLRDVTLVAHSMGGGELARYVGRHGTGRLRSAVLLSAI 121 Query: 362 FI-----PANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESV 416 NP+ P E A Q ++ + E Sbjct: 122 PPVMIKSDKNPDGVPDEVFDALKNGVLTERSQ-------------------FWKDTAEGF 162 Query: 417 LSMHKVCEAGGLFVNSPEEP--SLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWK 474 S G ++ ++ T E V F + F L + Sbjct: 163 FS---ANRPGNKVTQGNKDAFWYMAMAQTIEGGVRCVDAFGYTDFTEDLKKFD------- 212 Query: 475 WACKSLGRKILIPALMVTAEKDFVLVPQMSQHM-EDWIPHLKRGHIEDCGHWTQM---DK 530 IP L+V + D V+ + IP+ + E H M DK Sbjct: 213 -----------IPTLVVHGDDDQVVPIDATGRKSAQIIPNAELKVYEGSSHGIAMVPGDK 261 Query: 531 PTEVNQILIKWLD 543 + N+ L+++L+ Sbjct: 262 -EKFNRDLLEFLN 273 >4G5X-A nrPDB Length = 279 Score = 143 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 61/315 (19%), Positives = 107/315 (33%), Gaps = 53/315 (16%) Query: 235 SDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMK 294 + SHG + V+ G G + + HG S + Q+ +RV+A D+ Sbjct: 8 LETSHGRIAVR-------ESEGEGAPLLMIHGNSSSGAIFAPQLEGEIGKKWRVIAPDLP 60 Query: 295 GYGES-SAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVR 353 G+G+S A Y ME M + +LG++ AV G GG + M YPE +R Sbjct: 61 GHGKSTDAIDPDRSYSMEGYADAMTEVMQQLGIADAVVFGWSLGGHIGIEMIARYPE-MR 119 Query: 354 AVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASD 413 + TP + Q + P +A A Sbjct: 120 GLMITGTPPVAREEVG--------------QGFKSGPDMALA-----------------G 148 Query: 414 ESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNW 473 + + S V P E SL +V + + F+K G N Sbjct: 149 QEIFSERDVESYARSTCGEPFEASLLDIVARTDGRARRIMFEKFGSGTGGNQ-------- 200 Query: 474 KWACKSLGRKILIPALMVTAEKDFVLVPQ-MSQHMEDWIPHLKRGHIEDCGHWTQMDKPT 532 + + + +P +V + + +S+ + K I++ GH + P Sbjct: 201 ----RDIVAEAQLPIAVVNGRDEPFVELDFVSKVKFGNLWEGKTHVIDNAGHAPFREAPA 256 Query: 533 EVNQILIKWLDSDAR 547 E + L +++ + Sbjct: 257 EFDAYLARFIRDCTQ 271 >4NVR-A nrPDB Length = 307 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 113/309 (36%), Gaps = 33/309 (10%) Query: 242 VTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSA 301 V ++ + + GSG + L HG P++ +WR P LAQ + V+ D++GYG+S Sbjct: 24 VRLENGLTVRVAIGGSGSPLVLLHGHPQNHTTWRKVAPTLAQ-NHTVILPDLRGYGDSDK 82 Query: 302 P---PEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASL 358 P P Y + +++V +D LG S+ F+GHD GG + +AL YP+RV Sbjct: 83 PTSDPAHRTYSKRTMAQDIVMLMDALGFSRFAFVGHDRGGRVGHRLALDYPDRVT---CC 139 Query: 359 NTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLS 418 I M L + + + +P A D + Sbjct: 140 TFIDIAPTATMYALTDKSFATRYFWWFFLIQP------------FPLPETMIAHDPAFFL 187 Query: 419 MHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGF-RGPLNWYRNMER-NWKWA 476 + +G L + ++E Y++ ++ YR + Sbjct: 188 RKHI--SGQLKIEG--------ATSQEAFNEYLRCYQNPEMIHAICEDYRAAATIDLDDD 237 Query: 477 CKSLGRKILIPALMVTAEKDFVLVPQMSQHM-EDWIPHLKRGHIEDCGHWTQMDKPTEVN 535 +I P ++ V ++ +++ + CGH Q + P Sbjct: 238 AADTSARIRCPLQLLWGGLGTVGQLYNVVGTWKEKALNVQGEALP-CGHSPQEECPEYFI 296 Query: 536 QILIKWLDS 544 Q L +L S Sbjct: 297 QKLQSFLHS 305 >2PSJ-A nrPDB Length = 319 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 60/317 (18%), Positives = 114/317 (35%), Gaps = 51/317 (16%) Query: 248 VRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 + + E + AV HG S Y WR+ +P + R + D+ G G+S Sbjct: 34 INYYDSEKHAENAVIFLHGNATSSYLWRHVVPHIEPVA-RCIIPDLIGMGKSGK-SGNGS 91 Query: 308 YCMEVLCKEMVTFLDKLGL-SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPAN 366 Y + K + + + L L + +F+GHDWG L ++ A + +R++A+ + + Sbjct: 92 YRLLDHYKYLTAWFELLNLPKKIIFVGHDWGAALAFHYAYEHQDRIKAIVHMES------ 145 Query: 367 PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAG 426 + +ES P + + + E + +N Sbjct: 146 -VVDVIESWDEWPDIEEDIALIKSEEGEKMVLEN-------------------------- 178 Query: 427 GLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSG--FRGPLNWYRNMERNWKWACK------ 478 FV + + R + EE Y++ FK+ G R L+W R + Sbjct: 179 NFFVETVLPSKIMRKLEPEEFAAYLEPFKEKGEVRRPTLSWPREIPLVKGGKPDVVQIVR 238 Query: 479 ----SLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEV 534 L +P L + E D P+ + ++ H+ Q D P E+ Sbjct: 239 NYNAYLRASDDLPKLFI--ESDPGFFSNAIVEGAKKFPNTEFVKVKG-LHFLQEDAPDEM 295 Query: 535 NQILIKWLDSDARNPPV 551 + + +++ +N V Sbjct: 296 GKYIKSFVERVLKNEQV 312 >4RNC-A nrPDB Length = 310 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 54/303 (17%), Positives = 99/303 (32%), Gaps = 43/303 (14%) Query: 246 PRVRLHFVELGS--GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPP 303 + + G+ G + L HG+ +S W Q+ A A YR++A+D++G+G S AP Sbjct: 31 DGTSIVYRVTGNSAGTPLVLLHGWAQSSQCWGEQVLADLAADYRLIAVDLRGHGYSDAPE 90 Query: 304 EIEEYCMEVLCKEMVTFLDKLGL-SQAVFIGHDWGGMLVW-YMALFYPERVRAVASLNTP 361 + ++ L G+ A+ +G +GG+++ Y+A V + Sbjct: 91 SGYDDSAN-WAGDVAAVLAAEGVTENAILLGWSYGGLVICDYLAAHGTGAVAGAVLVGAI 149 Query: 362 FIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHK 421 + PG + + Sbjct: 150 TSIGRGE--------KGGKVGSAMRSAVPGAMSED----------------------PRE 179 Query: 422 VCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLG 481 A G F N+ P + + + Y R N L Sbjct: 180 AIRALGAFGNALTGPPEGKGAASQALFGYS--------LSTRPRVRAALFNRAVGHDELL 231 Query: 482 RKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKW 541 R + IP L++ D V+ +H E+ IP + + C H ++ PT + + Sbjct: 232 RNLDIPVLVLHGTDDSVVDVSAGKHAEELIPKSQASYWVGCNHGPFVEDPTRFVSEVRTF 291 Query: 542 LDS 544 + S Sbjct: 292 ISS 294 >3KXP-A nrPDB Length = 314 Score = 132 bits (331), Expect = 5e-31, Method: Composition-based stats. Identities = 53/300 (17%), Positives = 96/300 (32%), Gaps = 42/300 (14%) Query: 246 PRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEI 305 R+ L+ E GSGP + HG + + + L+ + +A+D +G+G S P Sbjct: 56 GRITLNVREKGSGPLMLFFHGITSNSAVFEPLMIRLSDR-FTTIAVDQRGHGLSDKPET- 113 Query: 306 EEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLN-TPFIP 364 Y ++ + L A+ +GH G A YP+ VR+V +++ TP+I Sbjct: 114 -GYEANDYADDIAGLIRTLARGHAILVGHSLGARNSVTAAAKYPDLVRSVVAIDFTPYIE 172 Query: 365 ANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCE 424 + + A F++ EA L R ES V Sbjct: 173 TEALDALEARVNAGS-----QLFEDIKAVEAYLAGRYPNIPADAIRIRAESGY--QPVDG 225 Query: 425 AGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKI 484 +S +R + + + Y R + Sbjct: 226 GLRPLASSAAMAQTARGLRSDLVPAY-------------------------------RDV 254 Query: 485 LIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDS 544 P L+V E ++ P L + H+ P + + ++D+ Sbjct: 255 TKPVLIVRGESSKLVSAAALAKTSRLRPDLPVVVVPGADHYVNEVSPEITLKAITNFIDA 314 >3OM8-A nrPDB Length = 266 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 54/307 (17%), Positives = 111/307 (36%), Gaps = 51/307 (16%) Query: 241 YVTVKPRVRLHFVELGSG--PAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGE 298 ++ L + G+ P + L + + + W Q+PAL + +RVL D +G+G Sbjct: 8 FLATSDGASLAYRLDGAAEKPLLALSNSIGTTLHMWDAQLPALTRH-FRVLRYDARGHGA 66 Query: 299 SSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASL 358 SS PP Y + L ++++ LD L + +A F+G GG++ ++AL P+R+ + Sbjct: 67 SSVPPG--PYTLARLGEDVLELLDALEVRRAHFLGLSLGGIVGQWLALHAPQRIERLVLA 124 Query: 359 NTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLS 418 NT A+ ++ ++ ++ + Sbjct: 125 NTSAWLGP---------------------------AAQWDERIAAVLQAEDMS------- 150 Query: 419 MHKVCEAGGLFVNSPEEPSLSRMV-TEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWAC 477 A G N L R E + + + G G R+ + Sbjct: 151 ----ETAAGFLGNWFPPALLERAEPVVERFRAMLMATNRHGLAGSFAAVRDTDL------ 200 Query: 478 KSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQI 537 ++ +I P L++ D V + + I + + H + ++ P Sbjct: 201 RAQLARIERPTLVIAGAYDTVTAASHGELIAASIAGARLVTLPAV-HLSNVEFPQAFEGA 259 Query: 538 LIKWLDS 544 ++ +L + Sbjct: 260 VLSFLGA 266 >4CCY-A nrPDB Length = 296 Score = 126 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 61/314 (19%), Positives = 110/314 (35%), Gaps = 56/314 (17%) Query: 234 PSDMSHGYVTVKPRVRLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAM 291 P + YV+ + + H + G P++ L HG S W I A + +R A+ Sbjct: 29 PIESEAFYVSTRFG-KTHIIASGPKDAPSLILLHGGLFSSAMWYPNIAA-WSSQFRTYAV 86 Query: 292 DMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPER 351 D+ G S P E + + M D LGL A G GG + L PER Sbjct: 87 DIIGDKNKSIPSAAMETRAD-FAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPER 145 Query: 352 VRAVASLNT--PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLF 409 V ++ FI +P++ + + + Y + +L L R + Sbjct: 146 VERAVVISPAEAFISFHPDVYKYAA-ELTGARGAESYIKWITGDSYDLHPLLQRQIVAGV 204 Query: 410 RASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNM 469 DE P E + T++E+ Sbjct: 205 EWQDEQ-------------RSLKPTENGFPYVFTDQEL---------------------- 229 Query: 470 ERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMS-QHMEDWIPHLKRGHIEDCGHWTQM 528 + I +P L++ E + + QM+ + +P ++ +++ GH + Sbjct: 230 ------------KSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLSL 277 Query: 529 DKPTEVNQILIKWL 542 ++P VNQ ++ +L Sbjct: 278 EQPEYVNQRVLSFL 291 >3V48-A nrPDB Length = 268 Score = 118 bits (294), Expect = 9e-27, Method: Composition-based stats. Identities = 51/280 (18%), Positives = 93/280 (33%), Gaps = 42/280 (15%) Query: 257 SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKE 316 P V L G S W Q+ L Q Y+V+ D +G G + E+Y + + E Sbjct: 14 DAPVVVLISGLGGSGSYWLPQLAVLEQE-YQVVCYDQRGTGN-NPDTLAEDYSIAQMAAE 71 Query: 317 MVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIK 376 + L G+ +GH G ++ +AL YP V + S+N + Sbjct: 72 LHQALVAAGIEHYAVVGHALGALVGMQLALDYPASVTVLISVN---------GWLRINAH 122 Query: 377 ANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEP 436 F + G A+A +E + + + A+ Sbjct: 123 TRRCFQVRERLLYSGGAQAWVEAQPLFLYPADWMAA------------------------ 158 Query: 437 SLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKD 496 R+ E+ + + F+G N R + + +I P ++ A D Sbjct: 159 RAPRLEAEDALAL-------AHFQGKNNLLRRLNALKRADFSHHADRIRCPVQIICASDD 211 Query: 497 FVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQ 536 ++ S + +P ++ + GH + P N Sbjct: 212 LLVPTACSSELHAALPDSQKMVMPYGGHACNVTDPETFNA 251 >4HTA-A nrPDB Length = 288 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 52/297 (17%), Positives = 112/297 (37%), Gaps = 46/297 (15%) Query: 255 LGSGPA-VCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPP-EIEEYC-ME 311 +GSG A + L HGF W++ +P L YRV+ D G G ++ + + Y +E Sbjct: 31 IGSGEATIVLGHGFGTDQSVWKHLVPHLVD-DYRVVLYDNMGAGTTNPDYFDFDRYSNLE 89 Query: 312 VLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSP 371 +++ L+ L + +F+GH M+ +L P+ + ++ N Sbjct: 90 GYSFDLIAILEDLKIESCIFVGHSVSAMIGVLASLNRPDLFSKIVMISASPRYVN----- 144 Query: 372 LESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVN 431 DYQ F++ ++L++ F+++ L + G + Sbjct: 145 --------DVDYQGGFEQ---------EDLNQLFEAIRSNYKAWCLGFAPLAVGGDMDSI 187 Query: 432 SPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMV 491 + +E S + +I V Q + + + +P ++ Sbjct: 188 AVQEFSRTLFNMRPDIALSVGQTIFQSDM-----------------RQILPFVTVPCHIL 230 Query: 492 TAEKDFVLVPQMSQHMEDWIPHLKRG--HIEDCGHWTQMDKPTEVNQILIKWLDSDA 546 + KD + +S+++ + + I GH Q+ P V ++++ + +D Sbjct: 231 QSVKDLAVPVVVSEYLHANL-GCESVVEVIPSDGHLPQLSSPDSVIPVILRHIRNDI 286 >1XRN-A nrPDB Length = 293 Score = 111 bits (277), Expect = 9e-25, Method: Composition-based stats. Identities = 50/301 (16%), Positives = 102/301 (33%), Gaps = 28/301 (9%) Query: 246 PRVRLHFVELGSGP---AVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAP 302 + +++ + + HG P + + + + + G VL D G G S P Sbjct: 13 NGIYIYYKLCKAPEEKAKLMTMHGGPGMSHDYLLSLRDMTKEGITVLFYDQFGCGRSEEP 72 Query: 303 PEIEEYCMEVLCKEMVTFLDKL-GLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTP 361 + ++ ++ +E KL G + +G +GG L A+ Y + ++ + Sbjct: 73 -DQSKFTIDYGVEEAEALRSKLFGNEKVFLMGSSYGGALALAYAVKYQDHLKGLIV---- 127 Query: 362 FIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHK 421 + PL + N + D + + S ++++ + Sbjct: 128 --SGGLSSVPLTVKEMNRLIDELPAKYRDAIKKYG----SSGSYENPEYQEAVNYFYHQH 181 Query: 422 VCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLG 481 + + + P E L + E Y GP N + W Sbjct: 182 LLRSE----DWPPE-VLKSLEYAERRNVYR------IMNGP-NQFTITGTIKDWDITDKI 229 Query: 482 RKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKW 541 I IP L+ E D V P +++ + + I + DC H T + N++L + Sbjct: 230 SAIKIPTLITVGEYDEV-TPNVARVIHEKIAGSELHVFRDCSHLTMWEDREGYNKLLSDF 288 Query: 542 L 542 + Sbjct: 289 I 289 >4JB3-A nrPDB Length = 228 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 45/215 (20%), Positives = 83/215 (38%), Gaps = 20/215 (9%) Query: 3 LRAAVFDLDGVLALPAVFGVLGRTEEA-LALPRGLLNDAFQKGGPEGATTRLMKGEITLS 61 ++ VFD GV+ + + LA L+ Q G L +G+++ Sbjct: 24 IKNIVFDFGGVIVDIDRDKAVQAFIKLGLADADTRLDKYHQTGI----FQELEEGKLSAD 79 Query: 62 QWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARK--INRPMLQAALMLRKKGFTT 119 ++ + + C + + +A ++ L L LRK Sbjct: 80 EFRKQLGDLCGRELTMEETK------------QAWLGFFNEVDLRKLDYILGLRKSYHVY 127 Query: 120 AIL-TNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPS 178 + TN ++ A + L + D L S Q+G KP P+I+ F++ PS Sbjct: 128 LLSNTNPFVMSWACSPEFSSEGKPLNDYCDKLYLSYQLGHTKPAPEIFDFMIKDSHVIPS 187 Query: 179 EVVFLDDIGANLKPARDLGMVTILVQDTDTALKEL 213 E +F+DD +N+ ++LG T ++ +EL Sbjct: 188 ETLFVDDGSSNIHIGKELGFETFQPENGADWRQEL 222 >1AZW-A nrPDB Length = 313 Score = 108 bits (269), Expect = 6e-24, Method: Composition-based stats. Identities = 57/309 (18%), Positives = 99/309 (32%), Gaps = 24/309 (7%) Query: 239 HGYVTVKPRVRLHFVELGS--GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGY 296 G + V R L+F + G+ G V + HG P + A YR++ D +G Sbjct: 13 QGSLKVDDRHTLYFEQCGNPHGKPVVMLHGGPGGGCN-DKMRRFHDPAKYRIVLFDQRGS 71 Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVA 356 G S+ ++ + L ++ LG+ + G WG L A +P++V + Sbjct: 72 GRSTPHADLVDNTTWDLVADIERLRTHLGVDRWQVFGGSWGSTLALAYAQTHPQQVTELV 131 Query: 357 SLNTPFIPA-NPNMSPLESIKANPVFDYQLYFQE-PGVAEAELEQNLSRTFKSLFRASDE 414 + E ++ Y P V A+L R S A+ Sbjct: 132 LRGIFLLRRFELEWFYQEGASRLFPDAWEHYLNAIPPVERADLMSAFHRRLTSDDEATRL 191 Query: 415 SVLSMHKVCEAGGLFVNSPEEP-----SLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNM 469 + V E F++ E+ + I+ + F GF Sbjct: 192 AAAKAWSVWEGATSFLHVDEDFVTGHEDAHFALAFARIENHY--FVNGGFF--------- 240 Query: 470 ERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMD 529 + R IP ++V D V Q + + P + GH Sbjct: 241 -EVEDQLLRDAHRIADIPGVIVHGRYDVVCPLQSAWDLHKAWPKAQLQISPASGHSAFE- 298 Query: 530 KPTEVNQIL 538 P V+ ++ Sbjct: 299 -PENVDALV 306 >2XMZ-A nrPDB Length = 269 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 49/289 (16%), Positives = 96/289 (33%), Gaps = 37/289 (12%) Query: 257 SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKE 316 + + HGF ++ I Y V+ +D+ G+GE E + + + Sbjct: 15 TNQVLVFLHGFLSDSRTYHNHIEKFTD-NYHVITIDLPGHGE-DQSSMDETWNFDYITTL 72 Query: 317 MVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIK 376 + LDK G+ GG + Y A+ + + +T E+ + Sbjct: 73 LDRILDKYKDKSITLFGYSMGGRVALYYAINGHIPISNLILESTSP------GIKEEANQ 126 Query: 377 ANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEP 436 + +A EL N LF++ E + + L + + Sbjct: 127 LERRLVDDARAKVLDIAGIELFVNDWEKLP-LFQSQLELPVEIQHQIRQQRLSQSPHKMA 185 Query: 437 SLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKD 496 R + P W R ++I +P L++ E D Sbjct: 186 KALR--------------DYGTGQMPNLWPR-------------LKEIKVPTLILAGEYD 218 Query: 497 FVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSD 545 V Q+++ M + IP+ K I GH ++ E + +++ +L + Sbjct: 219 EKFV-QIAKKMANLIPNSKCKLISATGHTIHVEDSDEFDTMILGFLKEE 266 >1Q0R-A nrPDB Length = 298 Score = 103 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 53/313 (16%), Positives = 103/313 (32%), Gaps = 25/313 (7%) Query: 241 YVTVKPRVRLHFVELGS--GPAVCLCHGFPESWYSWRYQIPA-LAQAGYRVLAMDMKGYG 297 + V L + G PA+ L G S W + LA G V+ D + G Sbjct: 4 RIVPSGDVELWSDDFGDPADPALLLVMGGNLSALGWPDEFARRLADGGLHVIRYDHRDTG 63 Query: 298 ESSAPP-EIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVA 356 S+ Y L + V LD G+ +A +G G + +AL + +R+ ++ Sbjct: 64 RSTTRDFAAHPYGFGELAADAVAVLDGWGVDRAHVVGLSMGATITQVIALDHHDRLSSLT 123 Query: 357 SLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESV 416 L + + + + ++ P D Q+P + L + Sbjct: 124 MLLGGGLDIDFDANIERVMRGEPTLDGLPGPQQPFLDALAL----------------MNQ 167 Query: 417 LSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWY-RNMERNWKW 475 + + E + E + ++ Y Sbjct: 168 PAEGRAAEVAKRVSKWRILSGTGVPFDDAEYARWEERAIDHAGGVLAEPYAHYSLTLPPP 227 Query: 476 ACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVN 535 + + R++ +P L++ AE D + +H+ IP + I GH P+ V+ Sbjct: 228 SRAAELREVTVPTLVIQAEHDPIAPAPHGKHLAGLIPTARLAEIPGMGHAL----PSSVH 283 Query: 536 QILIKWLDSDARN 548 L + + + R+ Sbjct: 284 GPLAEVILAHTRS 296 >5YHP-A nrPDB Length = 355 Score = 101 bits (251), Expect = 8e-22, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 103/296 (34%), Gaps = 31/296 (10%) Query: 244 VKPRVRLHFVELGS--GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSA 301 V P RL E G+ G V HG P S YR++ D +G GES+ Sbjct: 54 VSPLHRLSIKEYGNPQGKPVVFLHGGPGGGAS-DSDARRFNPTTYRIVLFDQRGSGESTP 112 Query: 302 PPEIEEYCMEVLCKEMVTFLDKLGLSQA-VFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 +E+ + L +++ + L + A G WG L A +P RV+++ Sbjct: 113 ASCLEDNTTQALVEDIEKIREFLQVGAAWHVFGGSWGSTLALAYAQAHPARVKSL----- 167 Query: 361 PFIPANPNMSPLESIKANPVFDYQLYFQEPGVA-------EAELEQNLSRTFKSLFRASD 413 L I + ++Q PG + E L+ + +A Sbjct: 168 ----------TLRGIFTLRKKELDFFYQGPGSSFVFPEYWEEYLDPIPVAERGDMVKAYY 217 Query: 414 ESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQ--FKKSGFRGPLNWYRNMER 471 E + + A S E + SR+ + + F + R +++ N Sbjct: 218 ERLTGSDEKVRAEAGRAWSRWEMATSRLHVDPDYISKADAPGFADAFARIESHYFVNGGF 277 Query: 472 NWK---WACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGH 524 + +++ + IPA++V D V + + P K I D GH Sbjct: 278 MPEGELLKPENIAKISHIPAVIVQGRYDMVCPITTAYELTKLWPEAKFVVIPDAGH 333 >1QTR-A nrPDB Length = 317 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 50/307 (16%), Positives = 103/307 (33%), Gaps = 21/307 (6%) Query: 240 GYVTVKPRVRLHFVELGS--GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYG 297 G++ R+++ G+ G HG P S + Y+VL D +G G Sbjct: 17 GWLDTGDGHRIYWELSGNPNGKPAVFIHGGPGGGISPHH-RQLFDPERYKVLLFDQRGCG 75 Query: 298 ESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVAS 357 S ++ L ++ + G+ Q + G WG L A +PERV + Sbjct: 76 RSRPHASLDNNTTWHLVADIERLREMAGVEQWLVFGGSWGSTLALAYAQTHPERVSEMVL 135 Query: 358 LNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASD-ESV 416 + + F + + + + + +++ ++ ++D + Sbjct: 136 RGIFTLRKQRLHWYYQ--DGASRFFPEKWERVLSILSDDERKDVIAAYRQRLTSADPQVQ 193 Query: 417 LSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWA 476 L K+ + S E++ + + F + + Sbjct: 194 LEAAKLWSVWEGETVTLLPSRESASFGEDDFALAFARIENHYF---------THLGFLES 244 Query: 477 CKSLGRKIL----IPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPT 532 L R + IPA++V D Q + + P + +E GH D+P Sbjct: 245 DDQLLRNVPLIRHIPAVIVHGRYDMACQVQNAWDLAKAWPEAELHIVEGAGH--SYDEPG 302 Query: 533 EVNQILI 539 ++Q++I Sbjct: 303 ILHQLMI 309 >4IH4-A nrPDB Length = 267 Score = 96.5 bits (238), Expect = 3e-20, Method: Composition-based stats. Identities = 53/299 (17%), Positives = 103/299 (34%), Gaps = 49/299 (16%) Query: 250 LHFVELGSGPAVCLC-HGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPP--EIE 306 L+ +G+G + HGF +W +P Q YRV+ D+ G S P + Sbjct: 10 LNVRVVGTGDRILFLAHGFGTDQSAWHLILPYFTQ-NYRVVLYDLVCAG-SVNPDYFDFN 67 Query: 307 EYC-MEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPA 365 Y ++ +++ +D LG+ ++GH M+ ++ PE + + F P Sbjct: 68 RYTTLDPYVDDLLNIVDSLGIQNCAYVGHSVSAMIGIIASIRRPELFSKLILIG--FSPR 125 Query: 366 NPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEA 425 N G E E+E+ S + E+ + Sbjct: 126 FLNDEDYHG----------------GFEEGEIEKVFSAMEANY-----EAWVHGFAPLAV 164 Query: 426 GGLFVNSPEEPSLSRMVTEEEIQFYVQQFK-KSGFRGPLNWYRNMERNWKWACKSLGRKI 484 G + E S + +I +V + S RG L + Sbjct: 165 GADVPAAVREFSRTLFNMRPDISLFVSRTVFNSDLRGVL------------------GLV 206 Query: 485 LIPALMVTAEKDFVLVPQMSQHMEDWI-PHLKRGHIEDCGHWTQMDKPTEVNQILIKWL 542 +P ++ KD + +++++ + ++ GH Q+ P ++ Q L + L Sbjct: 207 RVPTCVIQTAKDVSVPASVAEYLRSHLGGDTTVETLKTEGHLPQLSAPAQLAQFLRRAL 265 >1M33-A nrPDB Length = 258 Score = 94.5 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 49/292 (16%), Positives = 101/292 (34%), Gaps = 45/292 (15%) Query: 249 RLHFVELGSGPA-VCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 + + G G + L HG+ + WR L+ + + +D+ G+G S Sbjct: 3 NIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSH-FTLHLVDLPGFGRS------RG 55 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANP 367 + L L + +A+++G GG++ +AL +PERVRA+ ++ + + Sbjct: 56 FGALSLADMAEAVLQQAP-DKAIWLGWSLGGLVASQIALTHPERVRALVTVASSPCFSAR 114 Query: 368 NMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGG 427 + P IK D FQ+ L + RT + + + A Sbjct: 115 DEWP--GIKP----DVLAGFQQQ------LSDDQQRTVERFLALQTMGTETARQDARALK 162 Query: 428 LFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIP 487 V + P + G L + ++ + + + +P Sbjct: 163 KTVLALPMPEV------------------DVLNGGLEILKTVDL------RQPLQNVSMP 198 Query: 488 ALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILI 539 L + D ++ ++ ++ PH + H + P E +L+ Sbjct: 199 FLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFISHPAEFCHLLV 250 >3BF8-A nrPDB Length = 255 Score = 94.2 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 50/294 (17%), Positives = 93/294 (31%), Gaps = 60/294 (20%) Query: 256 GSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCK 315 + + L HG S + L + ++ +D++ +G S P + + + Sbjct: 14 HNNSPIVLVHGLFGSLDNLGVLARDLVN-DHNIIQVDVRNHGLSPREPVMN---YPAMAQ 69 Query: 316 EMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSP--LE 373 ++V LD + +A FIGH GG V + P+R+ + +++ + + Sbjct: 70 DLVDTLDAQQIDKATFIGHSMGGKAVMALTALAPDRIDKLVAIDIAPVDYHVRRHDEIFA 129 Query: 374 SIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSP 433 +I A D Q Q + L + Sbjct: 130 AINAVSESDAQTRQQAAAIMRQHLNE---------------------------------- 155 Query: 434 EEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLG----RKILIPAL 489 E IQF ++ F W N+ W +G PAL Sbjct: 156 ----------EGVIQFLLKSFVDG------EWRFNVPVLWDQYPHIVGWEKIPAWDHPAL 199 Query: 490 MVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLD 543 + + Q + P + I GHW +KP V + + ++L+ Sbjct: 200 FIPGGNSPYVSEQYRDDLLAQFPQARAHVIAGAGHWVHAEKPDAVLRAIRRYLN 253 >2WJ4-A nrPDB Length = 276 Score = 93.0 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 105/287 (36%), Gaps = 46/287 (16%) Query: 257 SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKE 316 GPA+ L G+ ++Y I L A +RV+ + +G+G S P E+ ++ + K+ Sbjct: 26 DGPAILLLPGWCHDHRVYKYLIQEL-DADFRVIVPNWRGHGLS--PSEVPDFGYQEQVKD 82 Query: 317 MVTFLDKLGLSQAVFIGHDWGG-MLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESI 375 + LD+LG+ + + H GG +LV + PER + Sbjct: 83 ALEILDQLGVETFLPVSHSHGGWVLVELLEQAGPERAPRGIIM----------------- 125 Query: 376 KANPVFDYQLYFQEPGVAEAE-LEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPE 434 D+ ++ +P A++ L ++ R + D ++++ + Sbjct: 126 ------DWLMWAPKPDFAKSLTLLKDPERWREGTHGLFD--------------VWLDGHD 165 Query: 435 EPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAE 494 E + + EE + + +SG + RN A + R P + ++ Sbjct: 166 EKRVRHHLLEEMADYGYDCWGRSGRVIEDAYGRNGSPMQMMANLTKTR----PIRHIFSQ 221 Query: 495 KDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKW 541 +++ + P + H+ +D P + ++ Sbjct: 222 PTEPEYEKINSDFAEQHPWFSYAKLGGPTHFPAIDVPDRAAVHIREF 268 >6AP7-A nrPDB Length = 269 Score = 91.5 bits (225), Expect = 9e-19, Method: Composition-based stats. Identities = 53/302 (17%), Positives = 102/302 (33%), Gaps = 53/302 (17%) Query: 250 LHFVELGSGP-AVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPP--EIE 306 L+ +GSG + L HGF +W +P + YRV+ D+ G S P + Sbjct: 11 LNVRVVGSGERVLVLAHGFGTDQSAWNRILPFFLR-DYRVVLYDLVCAG-SVNPDFFDFR 68 Query: 307 EYC-MEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPA 365 Y ++ +++ LD LG+ Q ++GH M+ ++ PE + + Sbjct: 69 RYTTLDPYVDDLLHILDALGIDQCAYVGHSVSAMIGILASIRRPELFSKLILIGASPRFL 128 Query: 366 NPNMSPLESIKANPVFDYQLYFQEPGVAE--AELEQNLSRTFKSLFRASDESVLSMHKVC 423 N DY F++ + + + +E N Sbjct: 129 NDE-------------DYHGGFEQGEIEKVFSAMEANYEAWVNGF------------APL 163 Query: 424 EAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFK-KSGFRGPLNWYRNMERNWKWACKSLGR 482 G + E S + +I +V + S RG L Sbjct: 164 AVGADVPAAVREFSRTLFNMRPDITLFVSRTVFNSDMRGVL------------------G 205 Query: 483 KILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDC-GHWTQMDKPTEVNQILIKW 541 + +P + +D + ++ ++++ + H + GH + PT + Q L + Sbjct: 206 LVKVPCHIFQTARDHSVPASVATYLKNHLGGKNTVHWLNIEGHLPHLSAPTLLAQELRRA 265 Query: 542 LD 543 L Sbjct: 266 LS 267 >2OCI-A nrPDB Length = 254 Score = 91.1 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 37/207 (17%), Positives = 71/207 (34%), Gaps = 8/207 (3%) Query: 246 PRVRLHFVELGSGP-AVCLCHGFPESW-YSWRYQIPALAQAGYRVLAMDMKGYGESSAPP 303 V+LH+ + G G AV L G S + Q+ L + + V+A D +GYG S P Sbjct: 10 NGVQLHYQQTGEGDHAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPD 69 Query: 304 -EIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPF 362 + E K+ V + L + +G GG+ A YP + + Sbjct: 70 RDFPADFFERDAKDAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANA 129 Query: 363 IPANPNMSPLESIKANPVFDYQLYFQEPGVAEAEL-----EQNLSRTFKSLFRASDESVL 417 + + E I+ + + + + E+ + + Sbjct: 130 YVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFKHLPDGNICR 189 Query: 418 SMHKVCEAGGLFVNSPEEPSLSRMVTE 444 + + L V+ ++P + R + Sbjct: 190 HLLPRVQCPALIVHGEKDPLVPRFHAD 216 >1DWO-A nrPDB Length = 262 Score = 89.2 bits (219), Expect = 5e-18, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 111/302 (36%), Gaps = 52/302 (17%) Query: 244 VKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPP 303 + V HF L H + W PAL +AG++V A+DM G P Sbjct: 2 ISKMVTAHF---------VLIHTICHGAWIWHKLKPALERAGHKVTALDMAASGID--PR 50 Query: 304 EIEEY-CMEVLCKEMVTFLDKLGL-SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT- 360 +IE+ + + ++TFL+KL + + +G G+ + A Y +++ A N+ Sbjct: 51 QIEQINSFDEYSEPLLTFLEKLPQGEKVIIVGESCAGLNIAIAADRYVDKIAAGVFHNSL 110 Query: 361 -PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSM 419 P +P+ + + +++ P + YF + + T K F E++ + Sbjct: 111 LPDTVHSPSYTVEKLLESFPDWRDTEYFTFTNITGETI-----TTMKLGFVLLRENLFTK 165 Query: 420 HKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKS 479 E + K R + + + K+ K Sbjct: 166 CTDGEY---------------------------ELAKMVMRKGSLFQNVLAQRPKFTEKG 198 Query: 480 LGRKILIPALMVTAEKDFVLVPQMSQ-HMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQIL 538 G I + + ++D + +P + + ++ P K ++ H Q+ K EV IL Sbjct: 199 YGS---IKKVYIWTDQDKIFLPDFQRWQIANYKPD-KVYQVQGGDHKLQLTKTEEVAHIL 254 Query: 539 IK 540 + Sbjct: 255 QE 256 >4NMW-A nrPDB Length = 259 Score = 88.4 bits (217), Expect = 7e-18, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 96/292 (32%), Gaps = 45/292 (15%) Query: 249 RLHFVELGSGPA-VCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEE 307 + + G G + L HG+ + W L + + +D+ GYG SS Sbjct: 6 DIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSH-FTLHLVDLPGYGRSS------G 58 Query: 308 YCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANP 367 + L + QA+++G GG++ MAL +PERV+A+ ++ + + Sbjct: 59 FGAMTLEEMTAQVAKNAP-DQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAR 117 Query: 368 NMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGG 427 P IK + G + +L + RT + + + Sbjct: 118 EGWP--GIKP----------EILGGFQQQLSDDFQRTVERFLALQTLGTETARQDARTLK 165 Query: 428 LFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIP 487 V + P + G L + ++ + + + +P Sbjct: 166 SVVLAQPMPDV------------------EVLNGGLEILKTVDL------REALKNVNMP 201 Query: 488 ALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILI 539 L + D ++ ++ ++ PH + H + P Q L+ Sbjct: 202 FLRLYGYLDGLVPRKIVPLLDTLWPHSTSQIMAKAAHAPFISHPAAFCQALM 253 >2YYS-A nrPDB Length = 286 Score = 87.2 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 50/308 (16%), Positives = 100/308 (32%), Gaps = 41/308 (13%) Query: 240 GYVTVKPRVRLHFVELG--SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYG 297 GYV V L+ ++G GPA+ + HG P + G+RV+ D +G G Sbjct: 6 GYVPVGEA-ELYVEDVGPVEGPALFVLHGGPGGNAYVLREGLQDYLEGFRVVYFDQRGSG 64 Query: 298 ES-SAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVA 356 S P + + ++ L ++ + + LG+ + + H +G ++ + +P+ Sbjct: 65 RSLELPQDPRLFTVDALVEDTLLLAEALGVERFGLLAHGFGAVVALEVLRRFPQ-AEGAI 123 Query: 357 SLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESV 416 L E+ P+ D E + EA + F L + Sbjct: 124 LLAPWVNFPWLAARLAEAAGLAPLPD-----PEENLKEALKREEPKALFDRLMFPTPRGR 178 Query: 417 LSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWA 476 ++ + E G+ L + RN W+ Sbjct: 179 MAYEWLAEGAGIL---------------------------GSDAPGLAFLRN--GLWRLD 209 Query: 477 CKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQ 536 P ++ E+D P + ++ + + GH+ +D P + Sbjct: 210 YTPYLTPERRPLYVLVGERDGTSYPYAEEVASRLRAPIR--VLPEAGHYLWIDAPEAFEE 267 Query: 537 ILIKWLDS 544 + L + Sbjct: 268 AFKEALAA 275 >1SCK-A nrPDB Length = 257 Score = 86.1 bits (211), Expect = 4e-17, Method: Composition-based stats. Identities = 54/285 (18%), Positives = 106/285 (37%), Gaps = 46/285 (16%) Query: 262 CLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEY-CMEVLCKEMVTF 320 L H + W P L G++V A+D+ G P +IEE + + ++TF Sbjct: 7 VLIHTICHGAWIWHKLKPLLEALGHKVTALDLAASGVD--PRQIEEIGSFDEYSEPLLTF 64 Query: 321 LDKLGL-SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT--PFIPANPNMSPLESIKA 377 L+ L + + +G GG+ + A Y E++ A N+ P P+ + ++ Sbjct: 65 LEALPPGEKVILVGESCGGLNIAIAADKYCEKIAAAVFHNSVLPDTEHCPSYVVDKLMEV 124 Query: 378 NPVFDYQLYF--QEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEE 435 P + YF + G L+ + ++L+ + PEE Sbjct: 125 FPDWKDTTYFTYTKDGKEITGLKLGFTLLRENLYT-------------------LCGPEE 165 Query: 436 PSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEK 495 L++M+T + + ++N+ + K I + V ++ Sbjct: 166 YELAKMLTRKG-----------------SLFQNILAKRPFFTKEGYGSI--KKIYVWTDQ 206 Query: 496 DFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 D + +P+ + K +E H Q+ K E+ +IL + Sbjct: 207 DEIFLPEFQLWQIENYKPDKVYKVEGGDHLLQLTKTKEIAEILQE 251 >3P2M-A nrPDB Length = 330 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 66/363 (18%), Positives = 113/363 (31%), Gaps = 61/363 (16%) Query: 188 ANLKPARDLGMVTILVQDTDTALKELEKVT-GIQLLNTPAPLPTSCNPSDMSHGYVTVKP 246 A++ + +G +L D T L E + + PLP V+ Sbjct: 22 ASMTGGQQMG--RVLSDDELTGLDEFALLAENAEQAGVNGPLP----------EVERVQA 69 Query: 247 RVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIE 306 GS P V HG ++ ++W I L G LA+D+ G+G S A E Sbjct: 70 GAISALRWGGSAPRVIFLHGGGQNAHTWDTVIVGL---GEPALAVDLPGHGHS-AWREDG 125 Query: 307 EYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPAN 366 Y ++ + + L +L +G GG+ +A P+ V + ++ Sbjct: 126 NYSPQLNSETLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLVDV-----T 180 Query: 367 PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAG 426 P+ AEL T + E Sbjct: 181 PSALQRH---------------------AELTAEQRGTVALM---HGEREFPSF------ 210 Query: 427 GLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNW---YRNMERNWKWACKSLGRK 483 + + +++ + F S NW Y + +A Sbjct: 211 ----QAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNWVWRYDAIRTFGDFAGLWDDVD 266 Query: 484 IL-IPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHI-EDCGHWTQMDKPTEVNQILIKW 541 L P +V + Q + + H + HI E GH Q D+P + +I+ Sbjct: 267 ALSAPITLVRGGSSGFVTDQDTAELHRRATHFRGVHIVEKSGHSVQSDQPRALIEIVRGV 326 Query: 542 LDS 544 LD+ Sbjct: 327 LDT 329 >3C5W-P nrPDB Length = 310 Score = 79.9 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 56/323 (17%), Positives = 114/323 (35%), Gaps = 45/323 (13%) Query: 226 APLPTSCNPSDMSHGYVTVKPRVRLH--FVELGSGPAVCLCHGFPESWYSWRYQIPA-LA 282 +P+P S M V + + GP + L HG S SW A ++ Sbjct: 8 SPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIIS 67 Query: 283 QAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKL--GL-SQAVFIGHDWGGM 339 + R++A+D++ +GE+ E+ E + K++ ++ + L + IGH GG Sbjct: 68 RVQCRIVALDLRSHGET-KVKNPEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHAMGGA 126 Query: 340 LVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQ 399 + + A V ++ L + + ++++ + F + + E +E Sbjct: 127 IAVHTASSN--LVPSLLGL---CMIDVVEGTAMDALNSMQNF-LRGRPKTFKSLENAIEW 180 Query: 400 NLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGF 459 ++ ++ S++ K CE + T +++ F Sbjct: 181 SVKSGQIRNLESARVSMVGQVKQCE--------------GKPYTWRIELAKTEKYWDGWF 226 Query: 460 RGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHI 519 RG N + IP L++ A D + M+ + + Sbjct: 227 RGLSNLF---------------LSCPIPKLLLLAGVDRLDKDLTIGQMQG---KFQMQVL 268 Query: 520 EDCGHWTQMDKPTEVNQILIKWL 542 CGH D P +V + + +L Sbjct: 269 PQCGHAVHEDAPDKVAEAVATFL 291 >4QLA-A nrPDB Length = 447 Score = 78.4 bits (191), Expect = 8e-15, Method: Composition-based stats. Identities = 60/350 (17%), Positives = 115/350 (32%), Gaps = 30/350 (8%) Query: 219 IQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHF------VELG-SGPAVCLCHGFPESW 271 ++ P + + T + +HF V G + L HG+P S Sbjct: 85 LKYWAEEYPFAERQKFLNQYPHFKTNIQGLNIHFMRITPKVPKGVEIVPLLLLHGWPGSV 144 Query: 272 YSWRYQIPALA----QAGY--RVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLG 325 + IP L + ++A + GYG S A + + +LG Sbjct: 145 REFYEAIPHLTAVSKDRNFALEIIAPSLPGYGFSDA-AVRPGLAAAEVAVIFKNLMARLG 203 Query: 326 LSQAVFIGHDWGGMLVWYMALFYPERVRA-----VASLNTPFIPANPNMSPLESIKANPV 380 Q G DWG ++ MA F+P+ + +L+ + S+ P Sbjct: 204 YKQYYVQGGDWGALIGSAMATFFPKEIIGFHSNMALTLSPAATFLEFVGALFPSLIVEPE 263 Query: 381 FDYQLYFQEPGVAEAELE---QNLSRTFKSL--FRASDESVLSMHKVCEAGGLFVN---- 431 +LY + E ++ T +D + + E + N Sbjct: 264 LANRLYPLSEKYSTLLEELGYMHIQATKPDTVGIGLTDSPAGLLAYILEKFSTWTNPDLR 323 Query: 432 SPEEPSLS-RMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALM 490 S E+ LS R ++ I + + + Y + + K ++ +P + Sbjct: 324 SKEDGGLSYRWTKDQLIDNLMLYWSTKSIVTSMRLYAESFSSRHFDLKLDEIQVQVPTWV 383 Query: 491 VTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 + A+ + P M + + IED GH+ + P + ++K Sbjct: 384 LQAKHELAYQPPCILKM-KYPKLVNASVIEDGGHFLAFELPEIFAKDVLK 432 >3IBT-A nrPDB Length = 264 Score = 76.1 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 37/302 (12%), Positives = 92/302 (30%), Gaps = 47/302 (15%) Query: 246 PRVRLHFVELGS--GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPP 303 + + E G P + L G+ + ++ P LA+ + V+ D +G+ + Sbjct: 7 NGTLMTYSESGDPHAPTLFLLSGWCQDHRLFKNLAPLLAR-DFHVICPDWRGH--DAKQT 63 Query: 304 EIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALF-YPERVRAVASLNTPF 362 + ++ + L ++++ F+D G+ + G + + R+ ++ Sbjct: 64 DSGDFDSQTLAQDLLAFIDAKGIRDFQMVSTSHGCWVNIDVCEQLGAARLPKTIIIDW-L 122 Query: 363 IPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKV 422 + +P + +P +Y Q AE N + + Sbjct: 123 LQPHPGFWQQLAEGQHPT-EYVAGRQSFFDEWAETTDNA------DVLNHLRNEMPWFH- 174 Query: 423 CEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGR 482 G ++ + E + + PL+ ++ + + Sbjct: 175 ---GEMWQRACREIEANY----------------RTWGSPLDRMDSLPQKPEICHIYSQP 215 Query: 483 KILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWL 542 D+ + W HI H+ ++ P V Q + ++L Sbjct: 216 LSQ----------DYRQLQLEFAAGHSWF---HPRHIPGRTHFPSLENPVAVAQAIREFL 262 Query: 543 DS 544 + Sbjct: 263 QA 264 >2WFL-A nrPDB Length = 264 Score = 74.9 bits (182), Expect = 8e-14, Method: Composition-based stats. Identities = 46/281 (16%), Positives = 97/281 (34%), Gaps = 36/281 (12%) Query: 262 CLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFL 321 L HG + W P L AG++V A+D+ G + E + + ++ + Sbjct: 14 VLVHGGCLGAWIWYKLKPLLESAGHKVTAVDLSAAGI-NPRRLDEIHTFRDYSEPLMEVM 72 Query: 322 DKLGL-SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM-SPLESIKANP 379 + + V +GH +GGM + YPE++ ++ N ++ P E Sbjct: 73 ASIPPDEKVVLLGHSFGGMSLGLAMETYPEKISVAVFMSAMMPDPNHSLTYPFEKYNEKC 132 Query: 380 VFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLS 439 D L Q E S++ + S E+ L+ Sbjct: 133 PADMMLDSQFSTYGNPE--------------NPGMSMILGPQFMALKMFQNCSVEDLELA 178 Query: 440 RMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVL 499 +M+T R +++++ + K++ + G + + +D Sbjct: 179 KMLT----------------RPGSLFFQDLAKAKKFSTERYGS---VKRAYIFCNEDKSF 219 Query: 500 VPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK 540 + + + + K I++ H + +P EV + L+ Sbjct: 220 PVEFQKWFVESVGADKVKEIKEADHMGMLSQPREVCKCLLD 260 >1Y7H-A nrPDB Length = 268 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 41/199 (20%), Positives = 74/199 (37%), Gaps = 14/199 (7%) Query: 257 SGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKE 316 G L HG +SW P L AG++V A+D+ G + E + Sbjct: 3 EGKHFVLVHGACHGGWSWYKLKPLLEAAGHKVTALDLAASG-TDLRKIEELRTLYDYTLP 61 Query: 317 MVTFLDKLGL-SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESI 375 ++ ++ L + + +GH GGM + YP+++ A L F+P + + S Sbjct: 62 LMELMESLSADEKVILVGHSLGGMNLGLAMEKYPQKIYAAVFLAA-FMPDSVHNSSFVLE 120 Query: 376 KANPVFDYQLYFQEPGVAEAELEQNLSRTF--------KSLFRASDESVLSMHKVCEAGG 427 + N + + + E+ L+ F K S E + + Sbjct: 121 QYNERTPAENWLDTQFLPYGSPEEPLTSMFFGPKFLAHKLYQLCSPEDLALASSLVRPSS 180 Query: 428 LFVNSPEEPSLSRMVTEEE 446 LF E+ S ++ T+E Sbjct: 181 LF---MEDLSKAKYFTDER 196 >2Y6V-A nrPDB Length = 398 Score = 73.4 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 46/308 (14%), Positives = 90/308 (29%), Gaps = 43/308 (13%) Query: 261 VCLCHGFPESWYSWRYQIPALAQAGY-------RVLAMDMKGYGESSAPPEIEEYCMEVL 313 + HG S W Y +P L A +VL +D +G+S+ + Sbjct: 55 LVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRG---RLGTN 111 Query: 314 CKEMVTFLDKLGLSQA------------VFIGHDWGGMLVWYMALFYPERVRAVASLNTP 361 + D L ++ V IGH GG + P + + Sbjct: 112 FNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIE-- 169 Query: 362 FIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHK 421 P + ++I A Q P L F E V M Sbjct: 170 -----PVVITRKAIGAGRPGLPPDSPQIPENLYNSLRLKTC----DHFANESEYVKYMRN 220 Query: 422 ---VCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACK 478 A + + + ++ ++E V+ + L Y NM+ + Sbjct: 221 GSFFTNAHSQILQNIIDFERTKASGDDEDGGPVRTKMEQAQN--LLCYMNMQT-FAPFLI 277 Query: 479 SLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKP----TEV 534 S + + + + + PQ ++ + + I H ++ P + Sbjct: 278 SNVKFVRKRTIHIVGARSNWCPPQNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERI 337 Query: 535 NQILIKWL 542 N + +++ Sbjct: 338 NHHIHEFV 345 >6COB-A nrPDB Length = 260 Score = 71.0 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 25/124 (20%), Positives = 51/124 (41%), Gaps = 4/124 (3%) Query: 262 CLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFL 321 L H + W P L AG+RV A+++ G P + E ++ K ++ L Sbjct: 8 VLVHNACHGAWIWYKLKPLLESAGHRVTAVELAASGIDPRPIQAVE-TVDEYSKPLIETL 66 Query: 322 DKLGL-SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT--PFIPANPNMSPLESIKAN 378 L + + +G +GG+ + A +P +++ + LN P P+ + ++ Sbjct: 67 KSLPENEEVILVGFSFGGINIALAADIFPAKIKVLVFLNAFLPDTTHVPSHVLDKLMEMF 126 Query: 379 PVFD 382 + Sbjct: 127 GGWG 130 >3RLI-A nrPDB Length = 270 Score = 69.5 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 44/202 (21%), Positives = 69/202 (34%), Gaps = 6/202 (2%) Query: 232 CNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAM 291 S MS Y V + E G V L HGF + +S R A A+AGY V Sbjct: 16 PRGSHMSEQY-PVLSGAEPFYAENGP-VGVLLVHGFTGTPHSMRPLAEAYAKAGYTVCLP 73 Query: 292 DMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLS--QAVFIGHDWGGMLVWYMALFYP 349 +KG+G + ++E + L G GG L Y+A +P Sbjct: 74 RLKGHG--THYEDMERTTFHDWVASVEEGYGWLKQRCQTIFVTGLSMGGTLTLYLAEHHP 131 Query: 350 ERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLF 409 + V IPA + + P V E E+ + + L Sbjct: 132 DICGIVPINAAVDIPAIAAGMTGGGELPRYLDSIGSDLKNPDVKELAYEKTPTASLLQLA 191 Query: 410 RASDESVLSMHKVCEAGGLFVN 431 R ++ + ++ +FV+ Sbjct: 192 RLMAQTKAKLDRIVCPALIFVS 213 >2VAV-A nrPDB Length = 444 Score = 69.1 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 57/351 (16%), Positives = 115/351 (32%), Gaps = 59/351 (16%) Query: 248 VRLHFVELGSGPA-----VCLCHGFPESWYS--WRY----QIPALAQAGYRVLAMDMKGY 296 V + + G V +CH S + W Q A + Y ++ ++ G Sbjct: 94 VPVAYKSWGRMNVSRDNCVIVCHTLTSSAHVTSWWPTLFGQGRAFDTSRYFIICLNYLGS 153 Query: 297 -----GESSAPPEIEE-------YCMEVLCKEMV---TFLDKLGLSQ-AVFIGHDWGGML 340 G S P+ E + + ++ LD+LG+ Q A +G GGM Sbjct: 154 PFGSAGPCSPDPDAEGQRPYGAKFPRTTIRDDVRIHRQVLDRLGVRQIAAVVGASMGGMH 213 Query: 341 VWYMALFYPERVRAVASLNTPFI-------------------------PANPNMSPLESI 375 A F PE VR + + T + + P+ + Sbjct: 214 TLEWAFFGPEYVRKIVPIATSCRQSGWCAAWFETQRQCIYDDPKYLDGEYDVDDQPVRGL 273 Query: 376 KANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEE 435 + Y +P + E +++ ++ S + ++G Sbjct: 274 ETARKIANLTYKSKPAMDE---RFHMAPGVQAGRNISSQDAKKEINGTDSGNSHRAGQPI 330 Query: 436 PSLSRMVTEEEIQFYVQQFKKSGFRGPLNWY--RNMERNWKWACKSLGRKILIPALMVTA 493 ++S + + Q + F + + + ++ R + I PAL++ A Sbjct: 331 EAVSSYL-RYQAQKFAASFDANCYIAMTLKFDTHDISRGRAGSIPEALAMITQPALIICA 389 Query: 494 EKDFVLVPQMSQHMEDWIPHLKRGHIE-DCGHWTQMDKPTEVNQILIKWLD 543 D + M IP+ + ++ + GH + + +VN + +LD Sbjct: 390 RSDGLYSFDEHVEMGRSIPNSRLCVVDTNEGHDFFVMEADKVNDAVRGFLD 440 >5OLW-A nrPDB Length = 227 Score = 69.1 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 41/204 (20%), Positives = 75/204 (36%), Gaps = 20/204 (9%) Query: 3 LRAAVFDLDGVLALPA--VFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL 60 +A +FDLDGV+ A F E + + G + +KG Sbjct: 2 FKAVLFDLDGVITDTAEYHFRAWKALAEEIGI-----------NGVDRQFNEQLKGVSRE 50 Query: 61 SQWIPLMEENCRKCSETAKVCLPKNFSIKEI-FDKAISARKINRPMLQAALMLRKKGFTT 119 +++ +K S L K + + + +S + +LQ LR Sbjct: 51 DSLQKILDLADKKVSAEEFKELAKRKNDNYVKMIQDVSPADVYPGILQLLKDLRSNKIKI 110 Query: 120 AILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSE 179 A+ + + + L +FD + + +V KP P I+ + +PSE Sbjct: 111 ALASAS--KNGP----FLLERMNLTGYFDAIADPAEVAASKPAPDIFIAAAHAVGVAPSE 164 Query: 180 VVFLDDIGANLKPARDLGMVTILV 203 + L+D A ++ +D G + I V Sbjct: 165 SIGLEDSQAGIQAIKDSGALPIGV 188 >4GDM-A nrPDB Length = 268 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 40/285 (14%), Positives = 77/285 (27%), Gaps = 50/285 (17%) Query: 259 PAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMV 318 P + HGF + W+ A A Y L +D+ G+G S+A + + + Sbjct: 31 PWLVFLHGFSGDCHEWQEVGEAFAD--YSRLYVDLPGHGGSAAISVDG---FDDVTDLLR 85 Query: 319 TFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKAN 378 L + +G+ GG + A + V Sbjct: 86 KTLVSYNILDFWLVGYSLGGRVAMMAACQGLAGLCGVIVEGG------------------ 127 Query: 379 PVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSL 438 PG+ AE R SD + +F + ++P Sbjct: 128 ----------HPGLQNAEQRAERQR--------SDRQWVQRFLTEPLTAVFADWYQQPVF 169 Query: 439 SRMVTEEEIQ-FYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDF 497 + + ++ + ++ + ++ R + E+D Sbjct: 170 ASLNDDQRRELVALRSNNNGATLAAMLEATSLAVQPDLRANLSARTFAF--YYLCGERDS 227 Query: 498 VLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWL 542 ++ D I GH + P V L + L Sbjct: 228 KFRALAAELAAD------CHVIPRAGHNAHRENPAGVIASLAQIL 266 >4G9B-A nrPDB Length = 243 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 38/229 (16%), Positives = 79/229 (34%), Gaps = 32/229 (13%) Query: 1 MTLRAAVFDLDGVLALPAV--FGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEI 58 M L+ +FDLDGV+ A F + + + +KG Sbjct: 3 MKLQGVIFDLDGVITDTAHLHFQAWQQIAAEIGISID------------AQFNESLKGIS 50 Query: 59 TLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKIN---RPMLQAALMLRKK 115 +++ ++ ++ + ++ ++ +N + LR + Sbjct: 51 RDESLRRILQHGGKEGDFNSQERAQLAYRKNLLYVHSLRELTVNAVLPGIRSLLADLRAQ 110 Query: 116 GFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKA 175 + + + + LA L EL+ F F ++ Q+ KP+P+I+ L Sbjct: 111 QISVGLASVSLNAP----TILAAL--ELREFFTFCADASQLKNSKPDPEIFLAACAGLGV 164 Query: 176 SPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNT 224 P + ++D A + GM ++ + +TG QLL Sbjct: 165 PPQACIGIEDAQAGIDAINASGMRSVGIG---------AGLTGAQLLLP 204 >3L5K-A nrPDB Length = 250 Score = 65.7 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 35/217 (16%), Positives = 68/217 (31%), Gaps = 26/217 (11%) Query: 7 VFDLDGVL--ALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWI 64 +FD+DG+L V + G +++ + L Sbjct: 34 IFDMDGLLLDTERLYSVVFQEICNRYDKKYSWDVKSLVMGKKALEAAQIIIDVLQLPMSK 93 Query: 65 PLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTN 124 + E + +KE+F A + + + LRK G A+ T+ Sbjct: 94 EELVEESQT-------------KLKEVFPTA----ALMPGAEKLIIHLRKHGIPFALATS 136 Query: 125 TWLDDRAERDGLAQLMCELKMHFDFLIESCQ--VGMVKPEPQIYKFLLDTLKASP--SEV 180 + + + L F ++ V KP+P I+ P + Sbjct: 137 SRSASFDMKTSRHKEFFSL---FSHIVLGDDPEVQHGKPDPDIFLACAKRFSPPPAMEKC 193 Query: 181 VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVT 217 + +D ++ A GM ++V D + + K T Sbjct: 194 LVFEDAPNGVEAALAAGMQVVMVPDGNLSRDLTTKAT 230 >2YY6-A nrPDB Length = 213 Score = 65.7 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 41/220 (18%), Positives = 78/220 (35%), Gaps = 36/220 (16%) Query: 3 LRAAVFDLDGVLALP--AVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL 60 +R +FDLDG L + L +T + L L ++ + G R + ++ Sbjct: 1 MRVILFDLDGTLIDSAKDIALALEKTLKELGLEEYYPDNVTKY---IGGGVRALLEKVLK 57 Query: 61 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA 120 ++ E RK V K + + L+ KGF A Sbjct: 58 DKFREEYVEVFRKHYLENPVVYTKPY----------------PEIPYTLEALKSKGFKLA 101 Query: 121 ILTNTWLDDRAERDGLAQLMCE---LKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASP 177 +++N + + L++ + + L +FD ++ G KP P L+ L P Sbjct: 102 VVSN-------KLEELSKKILDILNLSGYFDLIVGGDTFGEKKPSPTPVLKTLEILGEEP 154 Query: 178 SEVVFLDDIGANLKPARDLGMVTIL-----VQDTDTALKE 212 + + + D A+++ + G T L V+ Sbjct: 155 EKALIVGDTDADIEAGKRAGTKTALALWGYVKLNSQIPDF 194 >5W8P-A nrPDB Length = 370 Score = 65.7 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 52/352 (14%), Positives = 114/352 (32%), Gaps = 60/352 (17%) Query: 243 TVKPRVRLHFVELGSGPA-----VCLCHGFPESWYS-------------WRYQIP--ALA 282 V V + G V +CH + W I A Sbjct: 25 AVIDDVTIAVQSWGELSPRRDNVVFVCHALTADSHVVGPAGPDHITGGWWEGIIGPGAAI 84 Query: 283 QAGYRV-LAMDMKG-----YGESSAPPEIEEY-------CMEVLCKEMVTFLDKLGLSQ- 328 + +A ++ G G +S + + + + V L +LG+++ Sbjct: 85 DTDHWCAVATNVLGGCRGTTGPTSLARDGKPWGSRFPEVSVRDQVNADVAALAQLGITEV 144 Query: 329 AVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM----SPLESIKANPVF--- 381 A +G GG A+ +P+ VRA L + + + +I+ +P + Sbjct: 145 AAVVGGSMGGARALEWAVMHPDAVRAALVLAVGARATGDQIGTQSTQIAAIQTDPDWQGG 204 Query: 382 DYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEP-SLSR 440 DY + PG + T++ V + + + PE+P + R Sbjct: 205 DYHGSGRSPGKGLNLARRIAHLTYRGE-------VELDTRFGNDPQVGPDGPEDPWADGR 257 Query: 441 MVTEEEIQFYVQQFKKSGFRG-------PLNWYRNMERNWKWACKSLGRKILIPALMVTA 493 + ++ +F + G LN + + + R +P ++ Sbjct: 258 YAVQSYLEHQGNKFVRRFDAGSYVILTESLNRHDV--GRGRGGVEKALRGCPVPVVVGGI 315 Query: 494 EKDFVLVPQMSQHMEDWIPHLKRGHIEDC--GHWTQMDKPTEVNQILIKWLD 543 D + ++ + + D +P + + GH + + V++++ + L Sbjct: 316 TSDRLYPLRLQEELADLLPGCTGLRVVESVHGHDAFLIEFDAVSELVRETLA 367 >6EIC-C nrPDB Length = 279 Score = 64.9 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 101/308 (32%), Gaps = 64/308 (20%) Query: 246 PRVRLHFV----ELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSA 301 VR+ + + V L HG E + + L AG A+D +G+G S Sbjct: 14 GDVRIVYDVWTPDTAPQAVVVLAHGLGEHARRYDHVAQRLGAAGLVTYALDHRGHGRSGG 73 Query: 302 PPEIEEYCMEVLCKEMVTFLDKLGLS-------QAVFIGHDWGGMLVWYMALFYPERVRA 354 + + + T + G++ + + +GH GG +V+ + P+ Sbjct: 74 KRVLVR-DISEYTADFDTLV---GIATREYPGCKRIVLGHSMGGGIVFAYGVERPDNYD- 128 Query: 355 VASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDE 414 + L+ P + A +SP+ ++ A L PG+ EL+ Sbjct: 129 LMVLSAPAVAAQDLVSPVVAVAAK-----LLGVVVPGLPVQELD---------------- 167 Query: 415 SVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWK 474 F +P + + + + + R P R + + + Sbjct: 168 --------------FTAISRDPEVVQAYNTDPLVHHG--------RVPAGIGRALLQVGE 205 Query: 475 WACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWI--PHLKRGHIEDCGHWTQMDKPT 532 + P L++ D ++ + S+ + + + ++ H + P Sbjct: 206 -TMPRRAPALTAPLLVLHGTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVFNE-PE 263 Query: 533 EVNQILIK 540 NQ+L Sbjct: 264 R-NQVLDD 270 >5XKS-A nrPDB Length = 256 Score = 64.5 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 42/197 (21%), Positives = 71/197 (36%), Gaps = 6/197 (3%) Query: 237 MSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGY 296 M+ Y VK F G+ + + HGF S S R A +AGY V +KG+ Sbjct: 1 MTETYPVVKGAEPFFFE--GNDIGILVLHGFTGSPQSMRPLGEAYHEAGYTVCGPRLKGH 58 Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLDKLG--LSQAVFIGHDWGGMLVWYMALFYPERVRA 354 G + ++E+ + + + L G GG L YMA +PE Sbjct: 59 G--THYEDMEKTTCQDWIDSVEAGYEWLKNRCGTIFVTGLSMGGTLTLYMAEHHPEICGI 116 Query: 355 VASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDE 414 +PA + ++PGV E E+ + + + + + + Sbjct: 117 APINAAINMPALAGALAGVGDLPRFLDAIGSDIKKPGVKELAYEKTPAASIRQIVQLMER 176 Query: 415 SVLSMHKVCEAGGLFVN 431 +HK+ LF + Sbjct: 177 VKTDLHKITCPAILFCS 193 >5HK8-A nrPDB Length = 298 Score = 64.5 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 38/283 (13%), Positives = 72/283 (25%), Gaps = 44/283 (15%) Query: 255 LGSGPAV---CLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCME 311 G V HG + W L AG++ ++D+ G G S I + + Sbjct: 40 EGGAEPVIHFVFVHGASHGAWCWYKLTTLLDAAGFKSTSVDLTGAGISLIDSNIV-FDSD 98 Query: 312 VLCKEMVTFLDKLGLSQ-AVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMS 370 + + + L L + +GH GG V + +++ L + P Sbjct: 99 QYNRPLFSLLSDLPPHHKVILVGHSIGGGSVTEALCKFTDKISMAIYLAASMV--QPGSI 156 Query: 371 PLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFV 430 P + V + ++ G Sbjct: 157 PSPHLSNIHVGEEDIWEYTYGEG------------------------------------T 180 Query: 431 NSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKW-ACKSLGRKILIPAL 489 + P L + + + L M +P + Sbjct: 181 DKPPTGVLMKPEFIRHYYYSQSPLEDVTLSSKLLRPAPMRAFQDLDKLPPNPEAEKVPRV 240 Query: 490 MVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPT 532 + KD + + + P + +ED H PT Sbjct: 241 YIKTAKDNLFDSVRQDLLVENWPPSQLYVLEDSDHSAFFSVPT 283 >4FBL-A nrPDB Length = 281 Score = 64.1 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 5/146 (3%) Query: 237 MSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGY 296 MS + V P + +GS V + HGF S S R+ A+AGY V + G+ Sbjct: 31 MSTTPLQVLPGAEPLY-SVGSRIGVLVSHGFTGSPQSMRFLAEGFARAGYTVATPRLTGH 89 Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFI--GHDWGGMLVWYMALFYPERVRA 354 G + P E+ ++V + L V G GG L + A +PER Sbjct: 90 GTT--PAEMAASTASDWTADIVAAMRWLEERCDVLFMTGLSMGGALTVWAAGQFPERFAG 147 Query: 355 VASLNTPFIPANPNMSPLESIKANPV 380 + +N +P+++ L P Sbjct: 148 IMPINAALRMESPDLAALAFNPDAPA 173 >1TAH-B nrPDB Length = 318 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 55/320 (17%), Positives = 96/320 (30%), Gaps = 77/320 (24%) Query: 260 AVCLCHGFPESW------YSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVL 313 V L HG + W L G +V ++ G+ +S P E L Sbjct: 9 PVILVHGLAGTDKFANVVDYWYGIQSDLQSHGAKVYVANLSGF-QSDDGPNGRG---EQL 64 Query: 314 CKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLE 373 + L G ++ IGH GG+ Y+A P+ V +V ++ TP + + Sbjct: 65 LAYVKQVLAATGATKVNLIGHSQGGLTSRYVAAVAPQLVASVTTIGTPHRGSEFADFVQD 124 Query: 374 SIKANPVFDYQLYFQEPGVAEAELEQNLS--RTFKSLFRASDESVLSMHKVCEAGGLFVN 431 +K +P G++ + ++ T S +D+ Sbjct: 125 VLKTDPT----------GLSSTVIAAFVNVFGTLVSSSHNTDQ----------------- 157 Query: 432 SPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLN-----WYRNMERNWKWACKSLGRKILI 486 + + R +T + Y + F +G P + + + G I Sbjct: 158 --DALAALRTLTTAQTATYNRNFPSAGLGAPGSCQTGAATETVGGSQHLLYSWGGTAIQP 215 Query: 487 --PALMVTAEKD---------FVLVPQMSQHMEDW--IPHLKRG---------------H 518 L VT D V P + + + G Sbjct: 216 TSTVLGVTGATDTSTGTLDVANVTDPSTLALLATGAVMINRASGQNDGLVSRCSSLFGQV 275 Query: 519 IEDCGHWTQMDKPTEVNQIL 538 I HW + E+NQ+L Sbjct: 276 ISTSYHWNHL---DEINQLL 292 >1K8Q-A nrPDB Length = 377 Score = 63.0 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 52/347 (14%), Positives = 106/347 (30%), Gaps = 47/347 (13%) Query: 240 GYVTVKPRV---RLHFVELGSGPAVCLCHGFPESWYSWRYQIP------ALAQAGYRVLA 290 GY+ R+ R + +G P L HG S +W +P LA AGY V Sbjct: 37 GYILGIDRIPYGRKNSENIGRRPVAFLQHGLLASATNWISNLPNNSLAFILADAGYDVWL 96 Query: 291 MDMKGYG-------ESSAPPEIEEYCMEVLCK-EMVTFLD----KLGLSQAVFIGHDWGG 338 + +G S E + + + K ++ +D K G + ++GH G Sbjct: 97 GNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFILKKTGQDKLHYVGHSQGT 156 Query: 339 MLVWYMALFYPERVRAV----------------ASLNTPFIPANPNMSPLESIKANPVFD 382 + + P+ + + +N + + + K Sbjct: 157 TIGFIAFSTNPKLAKRIKTFYALAPVATVKYTETLINKLMLVPSFLFKLIFGNKIFYPHH 216 Query: 383 YQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMV 442 + F V E L + D L+M ++ ++ Sbjct: 217 FFDQFLATEVCSRETVDLLCSNALFIICGFDTMNLNMSRLDVYLSHNPAGTSVQNVLHWS 276 Query: 443 TEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQ 502 + + S + ++++++M + + +P + D + P Sbjct: 277 QAVKSGKFQAFDWGSPVQNMMHYHQSMPPYYNLT------DMHVPIAVWNGGNDLLADPH 330 Query: 503 MSQHMEDWIPHLKRGH-IEDCGHWTQ---MDKPTEVNQILIKWLDSD 545 + +P+L I H MD P V ++ + +D Sbjct: 331 DVDLLLSKLPNLIYHRKIPPYNHLDFIWAMDAPQAVYNEIVSMMGTD 377 >1R3D-A nrPDB Length = 264 Score = 62.6 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 88/293 (30%), Gaps = 55/293 (18%) Query: 259 PAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMV 318 P V L HG S W+ + LA+ L +D+ G+G + E + + + Sbjct: 17 PLVVLVHGLLGSGADWQPVLSHLARTQCAALTLDLPGHGTN------PERHCDNFAEAV- 69 Query: 319 TFLDKLGLSQ------AVFIGHDWGGMLVWY-MALFYPERVRAVASLNTPFIPANPNMSP 371 +++ + + +G+ GG L+ + +A R+ L I Sbjct: 70 EMIEQTVQAHVTSEVPVILVGYSLGGRLIMHGLAQGAFSRLN----LRGAIIEGGHFGLQ 125 Query: 372 LESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVN 431 KA Q + Q ++ +E LS ++ ++V S + L Sbjct: 126 ENEEKAARWQHDQQWAQR--FSQQPIEHVLSDWYQ-------QAVFSSLNHEQRQTLIAQ 176 Query: 432 SPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMV 491 S Q + + + +P V Sbjct: 177 RSANLGSSVAHMLLATSLAKQPYLLPALQA----------------------LKLPIHYV 214 Query: 492 TAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDS 544 E+D Q + + L + GH ++P +I+ + S Sbjct: 215 CGEQDSKF-----QQLAES-SGLSYSQVAQAGHNVHHEQPQAFAKIVQAMIHS 261 >5EFZ-A nrPDB Length = 361 Score = 61.4 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 41/265 (15%), Positives = 83/265 (31%), Gaps = 33/265 (12%) Query: 280 ALAQAGYRVLAMDMKGYGESSAPPE------IEEYCMEVLCKEMVT----FLDKLGLSQ- 328 AL + Y ++ ++ G G SS+ + + ++ + G+ Sbjct: 85 ALDPSKYCIIVVNQIGNGLSSSASNTGGSLAGPGFANVRIGDDVSAQHTLLTEYFGIESL 144 Query: 329 AVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMS----PLESIKANPVFDYQ 384 A+ +G G + A+ YP+ V+ A++ + + +E+I +P F Sbjct: 145 ALVVGGSMGAQQTYEWAVRYPDFVKRAAAIAGTARNSEHDFLFTEILIEAITTDPAFQAG 204 Query: 385 LYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTE 444 LY VA A LE++ + + L S + M + Sbjct: 205 LYRSSSAVA-AGLERHAKLWTLMGWSP------EFFRTGRHKALGFESMQ------MFVD 251 Query: 445 EEIQFYVQQFKKSGFRGPLNWY---RNMERNWKWACKSLGRKILIPALMVTAEKDFVLVP 501 ++ Y + + K+LGR I ++ D Sbjct: 252 GFMKRYFAPMDPNNLLTMAWKWQRGDVSRHTGGDLAKALGR-IKAKTYVMPISHDQFFTV 310 Query: 502 QMSQHMEDWIPHLKRGHIEDC-GHW 525 + IP+ + + GH Sbjct: 311 DDCLSEQKMIPNSEFRPLRSIDGHL 335 >3QUB-A nrPDB Length = 243 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 37/205 (18%), Positives = 71/205 (34%), Gaps = 21/205 (10%) Query: 3 LRAAVFDLDGVL--ALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLM-KGEIT 59 L+A +FD+DGVL ++P + + L G +T ++ + E+ Sbjct: 24 LKAVLFDMDGVLFNSMPYHSEAWHQVMKTHGLDLSREEAYMHAGRTGASTINIVFQRELG 83 Query: 60 LSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTT 119 +E K L ++ E A + ++ +G T Sbjct: 84 KEATQEEIESIYH-----EKSILFNSYPEAERMPGAW----------ELLQKVKSEGLTP 128 Query: 120 AILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSE 179 ++T + ER L + H + ++ + V KP P+ Y L E Sbjct: 129 MVVTGSGQLSLLER--LEHNFPGM-FHKELMVTAFDVKYGKPNPEPYLMALKKGGLKADE 185 Query: 180 VVFLDDIGANLKPARDLGMVTILVQ 204 V +++ ++ G+ TI V Sbjct: 186 AVVIENAPLGVEAGHKAGIFTIAVN 210 >1OIL-A nrPDB Length = 320 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 93/293 (31%), Gaps = 22/293 (7%) Query: 260 AVCLCHGF-PESWY-----SWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVL 313 + L HG Y W L Q G V ++ G+ +S P E L Sbjct: 10 PIILVHGLTGTDKYAGVLEYWYGIQEDLQQRGATVYVANLSGF-QSDDGPNGRG---EQL 65 Query: 314 CKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM---- 369 + T L G ++ +GH GG+ Y+A P+ V +V ++ TP + Sbjct: 66 LAYVKTVLAATGATKVNLVGHSQGGLTSRYVAAVAPDLVASVTTIGTPHRGSEFADFVQG 125 Query: 370 ---SPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAG 426 + + + + F + Q+ K+L A + ++ + Sbjct: 126 VLAYDPTGLSSTVIAAFVNVFGILTSSSNNTNQDALAALKTLTTAQA---ATYNQNYPSA 182 Query: 427 GLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGR-KIL 485 GL + T + + + + ++ + + L Sbjct: 183 GLGAPGSCQTGAP-TETVGGNTHLLYSWAGTAIQPTISVFGVTGATDTSTIPLVDPANAL 241 Query: 486 IPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQIL 538 P+ + V+V + S + + + + + + E+NQ+L Sbjct: 242 DPSTLALFGTGTVMVNRGSGQNDGVVSKCSALYGQVLSTSYKWNHLDEINQLL 294 >1HLG-A nrPDB Length = 371 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 56/335 (16%), Positives = 105/335 (31%), Gaps = 54/335 (16%) Query: 256 GSGPAVCLCHGFPESWYSWRYQIP------ALAQAGYRVLAMDMKGYG-------ESSAP 302 G P V L HG S +W +P LA AGY V + +G S Sbjct: 48 GQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDS 107 Query: 303 PEIEEYCMEVLCK-EMVTFLD----KLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVAS 357 E + + + K ++ +D K G Q ++GH G + + P + + Sbjct: 108 VEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRI-- 165 Query: 358 LNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQ--NLSRTFKSLFRASDES 415 ++P+ ++K +L F + + F F A++ Sbjct: 166 ------KTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVC 219 Query: 416 VLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKW 475 M + + LF+ + S+ + Y+ + + ++ K+ Sbjct: 220 SREMLNLLCSNALFIICGFD---SKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKF 276 Query: 476 ACKSLGRKIL-------------------IPALMVTAEKDFVLVPQMSQHMEDWIPHLKR 516 G + +P + KD + PQ + +P+L Sbjct: 277 QAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIY 336 Query: 517 G-HIEDCGHWTQ---MDKPTEVNQILIKWLDSDAR 547 I H MD P EV ++ + D + Sbjct: 337 HKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK 371 >1IMJ-A nrPDB Length = 210 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 34/111 (30%), Positives = 46/111 (41%), Gaps = 8/111 (7%) Query: 236 DMSHGYVTVKPRVRLHFVEL--GSGPA---VCLCHGFPESWYSWRYQ--IPALAQAGYRV 288 + G + V+ + L F E GSG A V L HG S +W+ + LAQAGYR Sbjct: 6 EQREGTIQVQGQA-LFFREALPGSGQARFSVLLLHGIRFSSETWQNLGTLHRLAQAGYRA 64 Query: 289 LAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGM 339 +A+D+ G G S + +D L L V I GM Sbjct: 65 VAIDLPGLGHSKEAAAPAPIGELAPGSFLAAVVDALELGPPVVISPSLSGM 115 Score = 42.2 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 30/61 (49%), Gaps = 2/61 (3%) Query: 483 KILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWL 542 + PAL+V ++D + Q S +P+ + ++ GH +DKP E + L+ +L Sbjct: 149 SVKTPALIVYGDQDP--MGQTSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFL 206 Query: 543 D 543 Sbjct: 207 Q 207 >1TE2-A nrPDB Length = 226 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 38/201 (18%), Positives = 75/201 (37%), Gaps = 20/201 (9%) Query: 5 AAVFDLDGVLAL--PAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQ 62 AA+FD+DG+L P +L + + + P+ R+ + Sbjct: 11 AAIFDMDGLLIDSEPLWDRAELDVMASLGVDI-----SRRNELPDTLGLRIDM---VVDL 62 Query: 63 WIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAIL 122 W N E + + + S+ E R + + +A + +++G + Sbjct: 63 WYARQPWNGPSRQEVVERVIARAISLVE------ETRPLLPGVREAVALCKEQGLLVGLA 116 Query: 123 TNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVF 182 + + L + M +L+ FD L + ++ KP PQ+Y L P V Sbjct: 117 SASPLHMLEKVLT----MFDLRDSFDALASAEKLPYSKPHPQVYLDCAAKLGVDPLTCVA 172 Query: 183 LDDIGANLKPARDLGMVTILV 203 L+D + ++ M +I+V Sbjct: 173 LEDSVNGMIASKAARMRSIVV 193 >3JWE-A nrPDB Length = 320 Score = 59.1 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 41/294 (13%), Positives = 83/294 (28%), Gaps = 52/294 (17%) Query: 251 HFVELGSGPAVCLC-HGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYC 309 ++ G+ A+ HG E + L V A D G+G+S + Sbjct: 51 YWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVS-D 109 Query: 310 MEVLCKEMVTFLDKLGLS----QAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPA 365 V ++++ +D + +GH GG + A P + + +P + A Sbjct: 110 FHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLI-SPLVLA 168 Query: 366 NPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEA 425 NP + + A V + L G ++ + + SD +C A Sbjct: 169 NPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLS--RNKTEVDIYNSDP------LICRA 220 Query: 426 GGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKIL 485 G + + + K+ Sbjct: 221 GLKVCFGIQLLNAVS-----------------------------------RVERALPKLT 245 Query: 486 IPALMVTAEKDFVLVPQMSQHMEDWIP--HLKRGHIEDCGHWTQMDKPTEVNQI 537 +P L++ D + + + + + E H + P N + Sbjct: 246 VPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSV 299 >5W8O-A nrPDB Length = 363 Score = 59.1 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 49/350 (14%), Positives = 112/350 (32%), Gaps = 60/350 (17%) Query: 243 TVKPRVRLHFVELGSGPA-----VCLCHGFPESWYSWRYQIPALAQAGY--RVL----AM 291 V V++ G V + H + P G+ V+ A+ Sbjct: 22 AVIDNVQIAVERWGELSPSRDNVVVVLHALTGDSHVAGPAGPNYPTPGWWDGVVGPGAAI 81 Query: 292 DMK-----------GYGESSAP----PEIEEY-------CMEVLCKEMVTFLDKLGLSQ- 328 D + G S+ P P+ + + + + + L+ +G+ Q Sbjct: 82 DTRRWCAIATNVLGGCRGSTGPGSLHPDGKAWGSRFPAVTVRDQVRADLAALNAMGIHQV 141 Query: 329 AVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM----SPLESIKANPVF--- 381 A +G GG + +PE VRA L + + + +IKA+P + Sbjct: 142 AAVVGGSMGGARALEWVIGHPETVRAGLILAVGARATADQIGTQSTQVAAIKADPNWQNG 201 Query: 382 DYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRM 441 DY +P V + T++ G + R Sbjct: 202 DYYGTGLKPDVGLQIARRFAHLTYRGEV----------ELDTRFGNAPQDDENPLLGGRY 251 Query: 442 VTEEEIQFYVQQFKKSGFRGPLNWY------RNMERNWKWACKSLGRKILIPALMVTAEK 495 E +++ ++ G ++ R + ++ R +P ++ Sbjct: 252 AVESYLEYQGRKLVDRFDAGTYVTLTDSLSSHDVGR-GRGGVEAALRSCEVPVVVGGFTS 310 Query: 496 DFVLVPQMSQHMEDWIPHLKRGHIEDC--GHWTQMDKPTEVNQILIKWLD 543 D + ++ + + + +P + ++ + GH + + V +++ + L+ Sbjct: 311 DRLYPLRLQEELAELMPGCRGLNVVESIYGHDGFLIETEAVGKLIRQTLE 360 >3NAS-A nrPDB Length = 233 Score = 59.1 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 32/199 (16%), Positives = 68/199 (34%), Gaps = 17/199 (8%) Query: 2 TLRAAVFDLDGVLALPA--VFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEIT 59 +L+A +FDLDGV+ A F E + +P + KG + I Sbjct: 1 SLKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKGISREESL----ESIL 56 Query: 60 LSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTT 119 + N K + I ++ + + + + L+ + Sbjct: 57 IFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLL-----PGIGRLLCQLKNENIKI 111 Query: 120 AILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSE 179 + +++ + R + F +++ + KP+P I+ L SP++ Sbjct: 112 GLASSSRNAPKILR------RLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDVSPAD 165 Query: 180 VVFLDDIGANLKPARDLGM 198 ++D A + + GM Sbjct: 166 CAAIEDAEAGISAIKSAGM 184 >4GIB-A nrPDB Length = 250 Score = 58.3 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 28/206 (13%), Positives = 69/206 (33%), Gaps = 19/206 (9%) Query: 3 LRAAVFDLDGVLALPAVFG--VLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL 60 + A +FDLDGV+ A + + + + + KG + + + Sbjct: 26 IEAFIFDLDGVITDTAYYHYMAWRKLAHKVGIDIDTKFNESLKGISRMESLDRI---LEF 82 Query: 61 SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA 120 E + K + + I++ I + + ++ Sbjct: 83 GNKKYSFSEEEKVRMAEEKNNYYVSLIDE------ITSNDILPGIESLLIDVKSNNIKIG 136 Query: 121 ILTNTWLDDRAERDGLAQL-MCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSE 179 + + + ++ + L + FDF+ ++ + KP P+I+ L +P Sbjct: 137 LSSAS-------KNAINVLNHLGISDKFDFIADAGKCKNNKPHPEIFLMSAKGLNVNPQN 189 Query: 180 VVFLDDIGANLKPARDLGMVTILVQD 205 + ++D A + M ++ V + Sbjct: 190 CIGIEDASAGIDAINSANMFSVGVGN 215 >3VVL-A nrPDB Length = 394 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 56/378 (14%), Positives = 106/378 (28%), Gaps = 73/378 (19%) Query: 228 LPTSCNPSDMSHGYVTVKPRV----RLHFVELGS-----GPAVCLCHGFPESWYS----- 273 +P + ++ G+ + R+ + GS AV + G ++ Sbjct: 25 IPPASRFIELPDGFAMRRGGALYGARIAYETFGSLNAARDNAVLVLTGLSPDAHAASRPD 84 Query: 274 ------WRYQIPALAQAG---YRVLAMDMKGYGE------SSAPPEIEEY-------CME 311 W + + V+ ++ G + S+ P E Y +E Sbjct: 85 DPTPGWWEAMVGPGKPVDTDLWHVICVNSLGSCKGSTGPASTDPRTGEPYRLSFPELSIE 144 Query: 312 VLCKEMVTFLDKLGLSQ-AVFIGHDWGGMLVWYMALFYPERVR----------------A 354 + + LG+S+ A +G GGM + +PE R A Sbjct: 145 DIADAAAHTVRALGISRLACVVGASMGGMSALALLARHPELARTHISLSGAVHALPFSIA 204 Query: 355 VASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEA----ELEQNLSRTFKSLFR 410 V SL I ++P + L ++ G+ E + RT R Sbjct: 205 VRSLQREAIRSDPGWLQGHYDEGEGPRRGMLTARKLGMMTYRSAQEWDCRFGRTRIGERR 264 Query: 411 ASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNME 470 +D+ V S + R + Y+ + Sbjct: 265 RADQGRFGPE-------FEVESYLDFHAQRFADRFDPNSYL--YLSHAMDQFDLGDGGGG 315 Query: 471 RNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWI----PHLKRGHIE-DCGHW 525 S R AL++ A D + Q + D + + ++ GH Sbjct: 316 GGGAPGALSRMRVER--ALVMGARTDILFPLSQQQEIADGLSAGGADVSFLPVDTPAGHD 373 Query: 526 TQMDKPTEVNQILIKWLD 543 + + K+L Sbjct: 374 AFLVDIERFGPPVAKFLA 391 >1R1D-A nrPDB Length = 247 Score = 55.3 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 59/173 (34%), Gaps = 10/173 (5%) Query: 251 HFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCM 310 F E G AV L HGF + R L GY A KG+G P E+ Sbjct: 10 FFFEAGE-RAVLLLHGFTGNSADVRMLGRFLESKGYTCHAPIYKGHGV--PPEELVHTGP 66 Query: 311 EVLCKEMV---TFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANP 367 + ++++ FL G + G GG+ + P + + ++ P + Sbjct: 67 DDWWQDVMNGYQFLKNKGYEKIAVAGLSLGGVFSLKLGYTVP--IEGIVTMCAPMYIKS- 123 Query: 368 NMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH 420 + E + +Y+ + + + +T +A E + + Sbjct: 124 EETMYEGV-LEYAREYKKREGKSEEQIEQEMERFKQTPMKTLKALQELIADVR 175 >3KSR-A nrPDB Length = 290 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 38/222 (17%), Positives = 75/222 (33%), Gaps = 21/222 (9%) Query: 259 PAVCLCHGFPESWYSWRYQIPALAQAGYRVLA--MDMKGY-GESSAPPEIEEYCMEVLCK 315 P V HG+ S + + A G + D++G+ G +S + Sbjct: 29 PGVLFVHGWGGSQH--HSLVRAREAVGLGCICMTFDLRGHEGYASMRQSV---TRAQNLD 83 Query: 316 EMVTFLDKL------GLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM 369 ++ D+L +G +GG L + P V +A + Sbjct: 84 DIKAAYDQLASLPYVDAHSIAVVGLSYGGYLSALLTRERP--VEWLALRSPALYKDAHWD 141 Query: 370 SPLESIKANPVF-DYQLYFQEPGVAEAELEQNLSRTFKSLFRASDES-VLSMHKVCEAGG 427 P S+ A+P DY+ PG + ++ + E+ V+ H V Sbjct: 142 QPKVSLNADPDLMDYRRRALAPG--DNLALAACAQYKGDVLLVEAENDVIVPHPVMRNYA 199 Query: 428 LFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNM 469 + + SR++ + V++ ++ R ++W M Sbjct: 200 DAFTNARSLT-SRVIAGADHALSVKEHQQEYTRALIDWLTEM 240 >2GFH-A nrPDB Length = 260 Score = 51.8 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 36/216 (16%), Positives = 76/216 (35%), Gaps = 20/216 (9%) Query: 3 LRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQ 62 +RA FDLD L A G + + LL + ++ +++ Sbjct: 18 VRAVFFDLDNTLIDTA-----GASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC 72 Query: 63 WIPLME--ENCRKCSETAKVCLPKNFSIKEIFDK----AISARKINRPML----QAALML 112 + P + R + K + + + ++ +L +A L Sbjct: 73 FHPYSTCITDVRTSHWEEAIQETKGGADNRKLAEECYFLWKSTRLQHMILADDVKAMLTE 132 Query: 113 RKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDT 172 +K +LTN D + +R+ + C + +FD ++ + KP P I+ D Sbjct: 133 LRKEVRLLLLTN--GDRQTQREKIEA--CACQSYFDAIVIGGEQKEEKPAPSIFYHCCDL 188 Query: 173 LKASPSEVVFLDDI-GANLKPARDLGMVTILVQDTD 207 L P + V + D +++ + G+ + + Sbjct: 189 LGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKS 224 >4ZWN-A nrPDB Length = 334 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 48/300 (16%), Positives = 89/300 (29%), Gaps = 49/300 (16%) Query: 261 VCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLC-KEMVT 319 V L HGF E + L+ GY D +G G +S P + E ++ Sbjct: 64 VLLIHGFGEYTKIQFRLMDHLSLNGYESFTFDQRGAGVTS-PGRSKGVTDEYHVFNDLEH 122 Query: 320 FLDKLGLSQA-------VFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPL 372 F++K LS+ GH GG + A + + + + Sbjct: 123 FVEK-NLSECKAKGIPLFMWGHSMGGGICLNYACQGKHKNEISGYIGSGPLI-------- 173 Query: 373 ESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNS 432 + + +P A L S + D ++ K A Sbjct: 174 -------ILHPHTMYNKPTQIIAPLLAKFSPRVRID-TGLDLKGITSDKAYRAFL----G 221 Query: 433 PEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVT 492 + S+ + +I ++Q RG + K K P +++ Sbjct: 222 SDPMSVPLYGSFRQIHDFMQ-------RGAKLYKNENNYIQKNFAKDK------PVIIMH 268 Query: 493 AEKDFVLVPQMSQHMEDWIP--HLKRGHIEDCGH-WTQMDKPTEVNQI---LIKWLDSDA 546 + D + P+ S+ P + H ++ N + + +WLD Sbjct: 269 GQDDTINDPKGSEKFIRDCPSADKELKLYPGARHSIFSLETDKVFNTVFNDMKQWLDKHT 328 >3FCY-A nrPDB Length = 346 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 46/188 (24%), Positives = 67/188 (35%), Gaps = 34/188 (18%) Query: 241 YVTVKPRVRLHFV-----ELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKG 295 Y T R+H G PA+ HG+ + W ++ +A AG+ V+AMD++G Sbjct: 86 YFTGVRGARIHAKYIKPKTEGKHPALIRFHGYSSNSGDWNDKLNYVA-AGFTVVAMDVRG 144 Query: 296 YGESSAPPEI------EEYCMEVLCKEMVT------FLDKLGLSQAV------------F 331 G S + + L + FLD L+ V Sbjct: 145 QGGQSQDVGGVTGNTLNGHIIRGLDDDADNMLFRHIFLDTAQLAGIVMNMPEVDEDRVGV 204 Query: 332 IGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKA--NPVFDYQLYFQE 389 +G GG L A P RVR V S PF+ + L+ K + DY F Sbjct: 205 MGPSQGGGLSLACAALEP-RVRKVVS-EYPFLSDYKRVWDLDLAKNAYQEITDYFRLFDP 262 Query: 390 PGVAEAEL 397 E E+ Sbjct: 263 RHERENEV 270 >5JKJ-A nrPDB Length = 370 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 45/289 (15%), Positives = 91/289 (31%), Gaps = 38/289 (13%) Query: 279 PALAQAGYRVLAMDMKGYGESSAPPEIEE--YCMEVLCKEMVTFLDKLGLSQ-AVFIGHD 335 P + G + D + P ++ + L+ LG+S+ IG Sbjct: 98 PHVITTGPTSINPD------TGKPYGLDFPVVTIRDFVNVQKALLESLGISKLYAVIGPS 151 Query: 336 WGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLE----SIKANPVFDYQLYFQEP- 390 G M A YP V + S+ + LE I + ++ Y +E Sbjct: 152 MGSMQAIDWASAYPGWVERMISVIGAGQSDAWTTAALEHWATPITLDKNWNNGAYSKEQA 211 Query: 391 ---GVAEAELEQNLSRTFKSLFRASDESVLS------MHKVCEAGGLFVNSPEEPSLSRM 441 G+A + + + S F + ++ VN E + +R Sbjct: 212 PLNGLAASLMLITQNALTPSFFNQTGNTLGYKNVESAPLNDIRQSHSIVNWLRERAKTRA 271 Query: 442 VTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVP 501 + + ++ ++ N+E I L + A+ D +L+P Sbjct: 272 KSMD--ANHLLYLVRACQLFVAGHQGNLE--------QGLASIKAKTLFIPAQTDLLLMP 321 Query: 502 QMSQHMEDWIP----HLKRGHI-EDCGHWTQMDKPTEVNQILIKWLDSD 545 +SQ + + GH + + Q + ++L++D Sbjct: 322 YLSQSAHQGLTSMNNDSTLVTLNGKLGHDEGVTNVSAQAQAIRQFLEND 370 >2HI0-A nrPDB Length = 240 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 43/237 (18%), Positives = 80/237 (33%), Gaps = 14/237 (5%) Query: 1 MTLRAAVFDLDGVLAL--PAVFGVLGRTEEALALPRGLL----NDAFQKGGPEGATTRLM 54 M +AA+FD+DG + + L E + F G T L Sbjct: 2 MKYKAAIFDMDGTILDTSADLTSALNYAFEQTGHRHDFTVEDIKNFFGSGVVVAVTRALA 61 Query: 55 KGEITLSQWIPLM---EENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALM 111 + + + +E + +V D +L Sbjct: 62 YEAGSSRESLVAFGTKDEQIPEAVTQTEVNRVLEVFKPYYADHCQIKTGPFPGILDLMKN 121 Query: 112 LRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLD 171 LR+KG A+++N + A + + +L FDF + KP P + + Sbjct: 122 LRQKGVKLAVVSNK--PNEAVQVLVEELFP---GSFDFALGEKSGIRRKPAPDMTSECVK 176 Query: 172 TLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPL 228 L + V++ D +++ AR+ M I V ++ L+K +++T L Sbjct: 177 VLGVPRDKCVYIGDSEIDIQTARNSEMDEIAVNWGFRSVPFLQKHGATVIVDTAEKL 233 >4KNV-A nrPDB Length = 241 Score = 49.1 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 34/218 (15%), Positives = 77/218 (35%), Gaps = 20/218 (9%) Query: 3 LRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQ 62 +RA FDLD L A G + + LL + ++ +++ Sbjct: 1 MRAVFFDLDNTLIDTA-----GASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC 55 Query: 63 WIP--LMEENCRKCSETAKVCLPKNFSIKEIFDK----AISARKINR----PMLQAALML 112 + P + R + K + + + ++ ++A L Sbjct: 56 FHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTE 115 Query: 113 RKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDT 172 +K +LTN D + +R+ + C + +FD ++ + KP P I+ + + Sbjct: 116 LRKEVRLLLLTN--GDRQTQREKIEA--CACQSYFDAVVVGGEQREEKPAPSIFYYCCNL 171 Query: 173 LKASPSEVVFLDDI-GANLKPARDLGMVTILVQDTDTA 209 L P + V + D +++ + G+ + + + Sbjct: 172 LGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKNGI 209 >3D2A-A nrPDB Length = 181 Score = 46.4 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 23/120 (19%), Positives = 41/120 (34%), Gaps = 17/120 (14%) Query: 260 AVCLCHGFPESWYSWRYQIPALAQAGY---RVLAMDM---KGYGESSAPPEIEEYCMEVL 313 V + HG + +++ L G+ ++ A+D G ++ P VL Sbjct: 5 PVVMVHGIGGASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGP---------VL 55 Query: 314 CKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMA--LFYPERVRAVASLNTPFIPANPNMSP 371 + + LD+ G + + H GG Y L +V V +L P Sbjct: 56 SRFVQKVLDETGAKKVDIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKAPP 115 Score = 31.0 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 24/155 (15%), Positives = 47/155 (30%), Gaps = 14/155 (9%) Query: 134 DGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPA 193 G ++ +D + + +LD A ++V GAN Sbjct: 29 QGWSRDKLYAVDFWDKT--GTNYNNGPVLSRFVQKVLDETGAKKVDIVAHSMGGAN---- 82 Query: 194 RDLGMVTILVQDTDTALKELEKVT---GIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRL 250 +++ D K VT +L AP T N + + + + Sbjct: 83 -----TLYYIKNLDGGNKVANVVTLGGANRLTTGKAPPGTDPNQKILYTSIYSSDDMIVM 137 Query: 251 HFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAG 285 +++ G HG + Q+ +L + G Sbjct: 138 NYLSRLDGARNVQIHGVGHMGLLYSSQVYSLIKEG 172 >4HXF-B nrPDB Length = 622 Score = 46.0 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 75/213 (35%), Gaps = 25/213 (11%) Query: 258 GPAVCLCHGFPES--WYSWRYQIPALAQAGYRVLAMDMKG-YGESS--APPEIEEYCMEV 312 P + HG P+ Y ++Y++ +A GY ++ ++ +G G S A +E +E Sbjct: 378 APVIVFVHGGPKGMYGYYFKYEMQLMASKGYYIVYVNPRGSNGYSEDFALRVLERTGLED 437 Query: 313 LCKEMVTFLDKL------GLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPAN 366 + + L + G +GG + AL + +A S N Sbjct: 438 FQDILNGIEEFLRLEPQADRERIGITGISYGGYMT-NWALTQSDLFKAGISENGISYWLT 496 Query: 367 PNMSPLESIKANPVFDYQLYFQEPGVAEAELE-QNLSRTFKSLFRASDESVLSMHKVCEA 425 + D L+F + + + LE +N + + + ++ L + E Sbjct: 497 ----------SYAFSDIGLWFDKEVIGDNPLENENYRKLSPLFYAKNVKAPLLLIHSLED 546 Query: 426 GGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSG 458 + ++ + + Y+ FKK Sbjct: 547 Y--RCPLDQSLMFYHVLKDLGKEVYIAIFKKGA 577 >5D6O-A nrPDB Length = 349 Score = 45.6 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 43/292 (14%), Positives = 93/292 (31%), Gaps = 56/292 (19%) Query: 267 FPESWYSWRYQIP----ALAQAGYRVLAMDMKGYGESSAPPEIEEYCME-------VLCK 315 + + +W Q AL + Y +++++ G G S +P + + + Sbjct: 58 YSGTHQTWFQQYIGTDHALDPSKYFIISINQIGNGLSVSPANTADDSISMSKFPNVRIGD 117 Query: 316 EMVT----FLDKLGLSQ-AVFIGHDWGGMLVWYMALFYPERVRAVASL-----NTPFIPA 365 ++V + G+++ +G G + + +P++V A + NTP Sbjct: 118 DVVAQDRLLRQEFGITELFAVVGGSMGAQQTYEWIVRFPDQVHRAAPIAGTAKNTPH-DF 176 Query: 366 NPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEA 425 + E+++A+P F+ G + E+ + + + EA Sbjct: 177 IFTQTLNETVEADPGFN--------GGEYSSHEEVADGLRRQSHLWAAMGFSTEFWKQEA 228 Query: 426 GGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGR--- 482 R + E + + F F + WKW + R Sbjct: 229 W-------------RRLGLESKESVLADFLDPLFMSMDPN-TLLNNAWKWQHGDVSRHTG 274 Query: 483 --------KILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIED-CGHW 525 ++ ++ +D + + IP + IED GH Sbjct: 275 GDLAAALGRVKAKTFVMPISEDMFFPVRDCAAEQALIPGSELRVIEDIAGHL 326 >3DYV-A nrPDB Length = 251 Score = 45.2 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 31/205 (15%), Positives = 62/205 (30%), Gaps = 4/205 (1%) Query: 252 FVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCME 311 F G+ V L H + S + AL ++GY V G+G + + + Sbjct: 16 FEYEGTDTGVVLLHAYTGSPNDMNFMARALQRSGYGVYVPLFSGHGTVEPLDILTKGNPD 75 Query: 312 VLCKEMVTFLDKL--GLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM 369 + E + + ++ G GG+ P + A ++P +P ++ Sbjct: 76 IWWAESSAAVAHMTAKYAKVFVFGLSLGGIFAMKALETLP-GITAGGVFSSPILPGKHHL 134 Query: 370 SPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLF 429 P A + E A L L+ + + + L Sbjct: 135 VPGFLKYAEYMNRLAGKSDESTQILAYLPGQLAAIDQFATTVAADLNLVKQPTFIGQAG- 193 Query: 430 VNSPEEPSLSRMVTEEEIQFYVQQF 454 + + L+ + + I F Sbjct: 194 QDELVDGRLAYQLRDALINAARVDF 218 >3I1I-A nrPDB Length = 377 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 29/215 (13%), Positives = 69/215 (32%), Gaps = 49/215 (22%) Query: 247 RVRLHFVELGS-----GPAVCLCHGFPESWYSWRYQIPALAQAG---------------- 285 V++ + G+ + +CH F + ++ ++G Sbjct: 26 PVQMGYETYGTLNRERSNVILICHYFSATSHAAGKYTAHDEESGWWDGLIGPGKAIDTNQ 85 Query: 286 YRVLAMDMK-------GYGESSAPPEIEEYCMEVLCKEM------------VTFLDKLGL 326 Y V+ D + ++ P I + + + +G+ Sbjct: 86 YFVICTDNLCNVQVKNPHVITTGPKSINPKTGDEYAMDFPVFTFLDVARMQCELIKDMGI 145 Query: 327 SQAVFI-GHDWGGMLVWYMALFYPERVRAVASL-----NTPFIPANPNMSPLESIKANPV 380 ++ + G GGM+ A+ YP V + + N N + +E+I+ +P Sbjct: 146 ARLHAVMGPSAGGMIAQQWAVHYPHMVERMIGVITNPQNPIITSVNVAQNAIEAIRLDPS 205 Query: 381 FDYQLYFQEP---GVAEAELEQNLSRTFKSLFRAS 412 + Y +E G+ A ++ + + + Sbjct: 206 WKGGKYGEEQPMKGLQLANRMMFMNAFDEHFYETT 240 >3FLA-A nrPDB Length = 267 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 45/274 (16%), Positives = 80/274 (29%), Gaps = 59/274 (21%) Query: 258 GPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEM 317 VCL H S + ALA A VLA+ G E + L + Sbjct: 21 ARLVCLPH-AGGSASFFFPLAKALAPAV-EVLAVQYPG--RQDRRHEPPVDSIGGLTNRL 76 Query: 318 VTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKA 377 + L G GH G ++ + +AL PE P +A Sbjct: 77 LEVLRPFGDRPLALFGHSMGAIIGYELALRMPE-----------AGLPAPVHLFASGRRA 125 Query: 378 NPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPS 437 + + ASDE +++ + S Sbjct: 126 PSRYRDD----------------------DVRGASDERLVAELRK-----------LGGS 152 Query: 438 LSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDF 497 + M+ + E+ V +S +R + GR++ P + T + D Sbjct: 153 DAAMLADPELLAMVLPAIRSDYRAVETYRHE-----------PGRRVDCPVTVFTGDHDP 201 Query: 498 VLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKP 531 + ++ E+ + GH+ +D+ Sbjct: 202 RVSVGEARAWEEHTTGPADLRVLPGGHFFLVDQA 235 >4GW3-A nrPDB Length = 307 Score = 43.3 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 26/106 (24%), Positives = 42/106 (39%), Gaps = 12/106 (11%) Query: 260 AVCLCHGFPESWYS-----WRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLC 314 + L HG + AL Q G++V + S + E + L Sbjct: 26 PIVLVHGLAGFNEIVGFPYFYGIADALRQDGHQV-------FTASLSAFNSNEVRGKQLW 78 Query: 315 KEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 + + T L + + FIGH G + Y+A YP+ V +V S+N Sbjct: 79 QFVQTLLQETQAKKVNFIGHSQGPLACRYVAANYPDSVASVTSING 124 >3O4I-A nrPDB Length = 582 Score = 43.3 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 33/177 (18%), Positives = 62/177 (35%), Gaps = 16/177 (9%) Query: 258 GPAVCLCHGFP--ESWYSWRYQIPALAQAGYRVLAMDMK---GYGESSAPPEIEEYCMEV 312 GP V L HG P E SW +LA AG+ V+ + + GYGE I + C Sbjct: 360 GPTVVLVHGGPFAEDSDSWDTFAASLAAAGFHVVMPNYRGSTGYGEEWRLKIIGDPCGGE 419 Query: 313 LCK--EMVTFLDKLGLS-QAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNM 369 L + + GL+ + +G+ +GG + P +A A ++ Sbjct: 420 LEDVSAAARWARESGLASELYIMGYSYGGYMTLCALTMKPGLFKAGV--------AGASV 471 Query: 370 SPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAG 426 E + ++ + ++ E+ ++ S +++ Sbjct: 472 VDWEEMYELSDAAFRNFIEQLTGGSREIMRSRSPINHVDRIKEPLALIHPQNASRTP 528 >5V41-A nrPDB Length = 286 Score = 42.9 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 35/282 (12%), Positives = 75/282 (26%), Gaps = 26/282 (9%) Query: 254 ELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVL 313 E G V + H S + + L D YG IEE + Sbjct: 17 EAGGKVPVFVFHPAGGSTVVYEPLLGRLPA--------DTPMYGFERVEGSIEERAQQ-- 66 Query: 314 CKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLE 373 + ++ G V +G GG+L + A+ + V + P Sbjct: 67 --YVPKLIEMQGDGPYVLVGWSLGGVLAYACAIGLRRLGKDVRFVGLIDAVRAGEEIPQT 124 Query: 374 SIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSP 433 + +D F E + + + V ++G Sbjct: 125 KEEIRKRWDRYAAFAEKTF--NVTIPAIPYEQLEELDDEGQVRFVLDAVSQSGVQIPAGI 182 Query: 434 EEPSLSRMVTEEEIQ-FYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRK-------IL 485 E + + I +Q + + Y + ++ Sbjct: 183 IEHQRTSYLDNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVSD 242 Query: 486 IPALMVTAEK----DFVLVPQMSQHMEDWIPHLKRGHIEDCG 523 + + + E D ++ ++ +HM + ++ + G Sbjct: 243 LEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADRTSEVG 284 >6FKX-A nrPDB Length = 324 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 71/209 (33%), Gaps = 35/209 (16%) Query: 227 PLPTSCNPSDMSHGYVTVKPRVRLHFVEL------GSGPAVCLCHGFPESWYSWRYQIPA 280 P + + SH + T VR+H L PA+ HG+ + W ++ Sbjct: 50 PAEFTTPLARCSHLWFTGTGGVRVHAKLLRPVAPVEPHPALLQFHGYTGNSGDWSSRL-H 108 Query: 281 LAQAGYRVLAMDMKG-YGESSAPPEIEEYCMEVL--------CKEMVTF----------- 320 GY V A+D +G G S +E + M + + Sbjct: 109 YVALGYTVAALDCRGQAGLSVGEAPVENWSMASYLLRGIDDDAADNLALRHLFLDTARLA 168 Query: 321 -----LDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESI 375 +D + + G+ GG L A P R+R +A+ PF+ ++ + Sbjct: 169 QIVLAMDDVDPDRVAATGYSQGGGLTLACAALEP-RIR-LAAPVYPFLCDFRRAWEMD-L 225 Query: 376 KANPVFDYQLYFQEPGVAEAELEQNLSRT 404 + P + YF+ E+ SR Sbjct: 226 EKGPYNEITTYFRARDPRHLREEEIFSRL 254 >5L8S-A nrPDB Length = 604 Score = 42.5 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 31/237 (13%), Positives = 72/237 (30%), Gaps = 28/237 (11%) Query: 257 SGPAVCLCHGFPESWY--SWRYQIPALAQAGYRVLAMDMKG---YGESSAPPEIEEYCME 311 +G + HG P+S +R GY + A + +G YG + ++ E Sbjct: 370 NGYTIFWPHGGPQSAERKMFRSMFQCFINRGYTIFAPNFRGSTGYGSAFTKLVELDWG-E 428 Query: 312 VLCKEMVTFLDKL------GLSQAVFIGHDWGGMLVWYMALFYPERVRAVA-SLNTPFIP 364 + + ++ L ++ +G +GG + + + + RAV + Sbjct: 429 GPRLDCIAGIEWLFESGFTDRNKLFLVGGSYGGYMALLLHGRHSDYFRAVVDIFGPSDLF 488 Query: 365 ANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCE 424 N P + E++ R K + ++ V + Sbjct: 489 TFINSVPPHWKPIMERWLGDP------------ERDKERFIKDSPVTYLDGMVKPMLVIQ 536 Query: 425 ---AGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACK 478 + ++ ++++ V + + GF N + + K Sbjct: 537 GAKDPRVVKEESDQIVAKLKEKGRDVEYLVLEDEGHGFSKKENEIKVYSLMLAFLEK 593 >3TEJ-A nrPDB Length = 329 Score = 42.2 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 35/205 (17%), Positives = 70/205 (34%), Gaps = 21/205 (10%) Query: 255 LGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIE---EYCME 311 G+GP + H P S ++W++ + + R L G S P ++ Sbjct: 98 EGNGPTLFCFH--PASGFAWQFSVLS------RYLDPQWSIIGIQSPRPNGPMQTAANLD 149 Query: 312 VLCKE-MVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLN--TPFIPANPN 368 +C+ + T L++ +G+ GG L +A R VA L + P N Sbjct: 150 EVCEAHLATLLEQQPHGPYYLLGYSLGGTLAQGIAARLRARGEQVAFLGLLDTWPPETQN 209 Query: 369 MSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGL 428 E+ +P ++ + A+ + F ++ ++V Sbjct: 210 WQEKEANGLDPEVLAEINREREAFLAAQQGSTSTELFTTIEGNYADAV-------RLLTT 262 Query: 429 FVNSPEEPSLSRMVTEEEIQFYVQQ 453 + P + + V E +Q + Sbjct: 263 AHSVPFDGKATLFVAERTLQEGMSP 287 >2PL5-A nrPDB Length = 366 Score = 42.2 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 37/312 (11%), Positives = 94/312 (30%), Gaps = 38/312 (12%) Query: 243 TVKPRVRLHFVELGS-----GPAVCLCHGFPESWYS-------------WRYQIPA---L 281 +V V + + G+ A+ +CH ++ W I Sbjct: 26 SVLSPVVIAYETYGTLSSSKNNAILICHALSGDAHAAGYHSGSDKKPGWWDDYIGPGKSF 85 Query: 282 AQAGYRVLAMDMKG--YGESS----APPEIEEY-------CMEVLCKEMVTFLDKLGLSQ 328 Y ++ ++ G G S P Y ++ + K ++ LG+ + Sbjct: 86 DTNQYFIICSNVIGGCKGSSGPLSIHPETSTPYGSRFPFVSIQDMVKAQKLLVESLGIEK 145 Query: 329 AVFI-GHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYF 387 + G GGM ++ YP + + + + ++ E + + D Sbjct: 146 LFCVAGGSMGGMQALEWSIAYPNSLSNCIVMASTAEHSAMQIAFNEVGRQAILSDPNWKN 205 Query: 388 QEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEI 447 L+R + SD+ + G +++ + ++ + + Sbjct: 206 GLYDENSPRKGLALARMVGHITYLSDDKMREKFGRNPPRGNILST--DFAVGSYLIYQG- 262 Query: 448 QFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHM 507 + +V +F + + + + L+V+ D++ P S+ + Sbjct: 263 ESFVDRFDANSYIYVTKALDHYSLGKGKELTAALSNATCRFLVVSYSSDWLYPPAQSREI 322 Query: 508 EDWIPHLKRGHI 519 + + Sbjct: 323 VKSLEAADKRVF 334 >1EX9-A nrPDB Length = 285 Score = 42.2 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 23/108 (21%), Positives = 39/108 (36%), Gaps = 12/108 (11%) Query: 260 AVCLCHG-----FPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLC 314 + L HG W AL + G +V ++ S E+ + Sbjct: 9 PIVLAHGMLGFDNILGVDYWFGIPSALRRDGAQVYVTEVSQLDTS----EVRGEQLLQQV 64 Query: 315 KEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPF 362 +E+V G + IGH GG + Y+A P+ + + S+ P Sbjct: 65 EEIVALS---GQPKVNLIGHSHGGPTIRYVAAVRPDLIASATSVGAPH 109 >3E4D-A nrPDB Length = 278 Score = 41.8 bits (96), Expect = 9e-04, Method: Composition-based stats. Identities = 23/170 (13%), Positives = 51/170 (30%), Gaps = 9/170 (5%) Query: 299 SSAPPEIEEYCMEVLCKEMVTFLDK---LGLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 + P + +E+ + + +S+ GH GG +AL PER ++ Sbjct: 109 TEEPWSEHYQMYSYVTEELPALIGQHFRADMSRQSIFGHSMGGHGAMTIALKNPERFKSC 168 Query: 356 ASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDES 415 ++ P++ + S K + L ++ +R + L Sbjct: 169 SAFAPIVAPSSADWSEPALEKYLGADRAAWRRYD----ACSLVEDGARFPEFLIDQGKAD 224 Query: 416 VLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNW 465 LF + + + + + + F + L W Sbjct: 225 SFLE--KGLRPWLFEEAIKGTDIGLTLRMHDRYDHSYYFISTFMDDHLKW 272 >3N0T-A nrPDB Length = 469 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 37/232 (15%), Positives = 73/232 (31%), Gaps = 28/232 (12%) Query: 256 GSGPAVCLCHGFPESWYSWRYQIPALAQ----AGYRVLAMDMKGYGES---SAPPEIEEY 308 G G + G +++ +A+ G ++ + + YG+S A + Sbjct: 44 GEG-PIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGH 102 Query: 309 C--------MEVLCKEMVTFLDKLGLSQA--VFIGHDWGGMLVWYMALFYPERVRAVASL 358 + + + LG A + G +GGML Y+ + YP V + Sbjct: 103 TELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAA 162 Query: 359 NTPFIPANPNMSPLESIKANPV-FDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVL 417 + P + + + F+ Q GV EA + + + ++V Sbjct: 163 SAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREA-----FRQIKDLFLQGAYDTVR 217 Query: 418 SMHKVCEAGGLFVNSPEEPSLSR-MVTEEEIQFYVQQFKKSGFRGPLNWYRN 468 C+ + + +R T + Y + F GPL Sbjct: 218 WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYP---TDFLGPLPANPV 266 >3WYD-A nrPDB Length = 228 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 25/131 (19%), Positives = 41/131 (31%), Gaps = 22/131 (16%) Query: 243 TVKPRVRLHFVELGSGPAVCLCHGFPESWYSW--RYQIPAL----AQAGYRVLAMDMKGY 296 T + P V HG S+ YQ A GY V + Sbjct: 29 TTYDGTKAF-------PLVIALHGMGGDENSYFDSYQRGAFMIEAENRGYIVACPKGR-- 79 Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLD---KLGLSQAVFIGHDWGGMLVWYMALFYPERVR 353 P + E +++ + K+ + GH GG W +A+ +P+ Sbjct: 80 ----QPASMYVGPAERDVMDVIAEVRRDYKIDPDRIYMTGHSMGGYGTWSIAMNHPDVFA 135 Query: 354 AVASLNTPFIP 364 A+A + P Sbjct: 136 ALAPVAGGGNP 146 >4RN3-A nrPDB Length = 213 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 68/200 (34%), Gaps = 25/200 (12%) Query: 2 TLRAAVFDLDGVLALPAVFGV--LGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEIT 59 ++A ++D DGV+ + R E + PR ++ Q E+ Sbjct: 10 AIKAVIYDCDGVMFDSFEANLAFYQRIMEMMGRPRLSRDNEEQM----RILHTYANREV- 64 Query: 60 LSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKK-GFT 118 L+ + P + + A + + + + +A L+ + G Sbjct: 65 LAHFFPSPGD-WEEAVRCAGAID---------YRELVPLMIMEEGFREALDTLKGRVGLG 114 Query: 119 TAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPS 178 +T +D + L +F ++ + +V KP P+ +L+ P Sbjct: 115 VCTNRSTSMDMVLR-------LFSLDSYFSIVMTASRVTNPKPHPEPLLKVLEHFGIGPR 167 Query: 179 EVVFLDDIGANLKPARDLGM 198 E +F+ D + A G+ Sbjct: 168 EALFVGDSEVDRLSAEAAGV 187 >4QLO-A nrPDB Length = 360 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 56/154 (36%), Gaps = 21/154 (13%) Query: 244 VKPRVRLHFVELG--SGPAVCLCHGFPESWYS---------WRYQIP--ALAQAGYRVLA 290 V +RL + +G P V +CH + + WR I + Y+ L Sbjct: 21 VIDNLRLRYEHVGYHGQPLVVVCHALTGNHLTYGTDDYPGWWREIIDGGYIPIHDYQFLT 80 Query: 291 MDMKG--YGESSAPPEIEEYCMEVLCKEMVTF----LDKLGLSQA-VFIGHDWGGMLVWY 343 D+ G +G SS+P + ++ +++V + LG + + IG GGM Sbjct: 81 FDVIGSPFG-SSSPLNDPHFPKKLTLRDIVRANERGIQALGYDKINILIGGSLGGMQAME 139 Query: 344 MALFYPERVRAVASLNTPFIPANPNMSPLESIKA 377 + V L ++ + + E + Sbjct: 140 LLYNQQFEVDKAIILAATSRTSSYSRAFNEIARQ 173 >2HDO-A nrPDB Length = 209 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 35/204 (17%), Positives = 61/204 (29%), Gaps = 33/204 (16%) Query: 1 MTLRAAVFDLDGVLA--LPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEI 58 MT +A +FD+DG L PA V+ P QK P A + + I Sbjct: 2 MTYQALMFDIDGTLTNSQPAYTTVMREVLATYGKP--FSPAQAQKTFPMAAEQAMTELGI 59 Query: 59 TLSQW--IPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALM-LRKK 115 S++ E+ P S+ E + + +R Sbjct: 60 AASEFDHFQAQYEDVMASHYDQIELYPGITSLFEQLPSELRLGIVTSQRRNELESGMRSY 119 Query: 116 GFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKA 175 F + DD +R KP+P L+ + Sbjct: 120 PFMMRMAVTISADDTPKR--------------------------KPDPLPLLTALEKVNV 153 Query: 176 SPSEVVFLDDIGANLKPARDLGMV 199 +P +F+ D ++ + A+ + Sbjct: 154 APQNALFIGDSVSDEQTAQAANVD 177 >3H2H-A nrPDB Length = 397 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 33/246 (13%), Positives = 72/246 (29%), Gaps = 22/246 (8%) Query: 275 RYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVT------FLDKLGL-- 326 + LA GY V+ D G G+S+ + + L L Sbjct: 107 DPLVTRLASQGYVVVGSDYLGLGKSNYAYHPYLHSASEASATIDAMRAARSVLQHLKTPL 166 Query: 327 -SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQL 385 + + G+ GG + L + P + + + Sbjct: 167 SGKVMLSGYSQGGHTAMATQREIEAHLSKEFHLVASAPISGPYALEQTFLDSWSGSNAVG 226 Query: 386 YFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH--KVCEAGGLFVNSPEEPSLSRMVT 443 + + + T+K+++ + KV + + + + Sbjct: 227 ENTFFILLGSYAIVAMQHTYKNIYLEPGQVFQDPWAAKVEPLFPGKQSLTDMFLNDTLPS 286 Query: 444 EEEIQFYVQQFKKSGFRG-PLNWYRN---MERNWKWACKSLGRKILIPALMVTAEKDFVL 499 ++++ Y Q S F P N +R +WA ++ P L+ + D + Sbjct: 287 IDKVKSYFQPGFYSDFPSNPANPFRQDLARNNLLEWAPQT-------PTLLCGSSNDATV 339 Query: 500 VPQMSQ 505 + +Q Sbjct: 340 PLKNAQ 345 >2EEP-A nrPDB Length = 706 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 55/294 (18%), Positives = 93/294 (31%), Gaps = 57/294 (19%) Query: 123 TNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKP------EPQIYKFLLDTLKAS 176 +N ++ RDG L L LI G + +P+ + ++ +AS Sbjct: 321 SNNQFIWQSRRDGWNHLY--LYDTTGRLIRQVTKGEWEVTNFAGFDPKGTRLYFESTEAS 378 Query: 177 PSEVVFLDDIGANLKPAR------DLGMVTI-LVQDTDTALKELE------KVTGIQLLN 223 P E F ++K + + GM L D + + KVT + Sbjct: 379 PLERHFY---CIDIKGGKTKDLTPESGMHRTQLSPDGSAIIDIFQSPTVPRKVTVTNIGK 435 Query: 224 TPAPLPTSCNPS------DMSHGYVTVKPRVR---------LHFVELGSGPAVCLCHGFP 268 L + NP ++ G + LHF P + +G P Sbjct: 436 GSHTLLEAKNPDTGYAMPEIRTGTIMAADGQTPLYYKLTMPLHFDPAKKYPVIVYVYGGP 495 Query: 269 ESW---YSWRYQI----PALAQAGYRVLAMDMKGY---GESSAPPEIEEYCMEVLCKEMV 318 + +WR + +AQ GY V +D +G G + + +M Sbjct: 496 HAQLVTKTWRSSVGGWDIYMAQKGYAVFTVDSRGSANRGAAFEQVIHRRLGQTEMADQMC 555 Query: 319 TFLDKL------GLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPAN 366 D L + G +GG + + L + + V V P I N Sbjct: 556 GV-DFLKSQSWVDADRIGVHGWSYGGFMTTNLMLTHGD-VFKVGVAGGPVIDWN 607 >2B61-A nrPDB Length = 377 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 55/340 (16%), Positives = 108/340 (31%), Gaps = 52/340 (15%) Query: 248 VRLHFVELGS-----GPAVCLCH------------GFPESWYSWRYQIPALAQAGYRVLA 290 + + + G+ AV +CH G W ++ AL Y ++ Sbjct: 44 INVAYQTYGTLNDEKNNAVLICHALTGDAEPYFDDGRDGWWQNFMGAGLALDTDRYFFIS 103 Query: 291 MDMKG-----YGESSA-PPEIEEYC-------MEVLCKEMVTFLDKLGLSQ-AVFIGHDW 336 ++ G G SS P + Y ++ + K L+ LG+S IG + Sbjct: 104 SNVLGGCKGTTGPSSINPQTGKPYGSQFPNIVVQDIVKVQKALLEHLGISHLKAIIGGSF 163 Query: 337 GGMLVWYMALFYPERVRAVA-SLNTPFIPAN---PNMSPLESIKANPVFDYQLYFQE--- 389 GGM A+ YP+ + + ++ + A N +++ +P F+ Y++ Sbjct: 164 GGMQANQWAIDYPDFMDNIVNLCSSIYFSAEAIGFNHVMRQAVINDPNFNGGDYYEGTPP 223 Query: 390 -PGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQ 448 G++ A + L+ + V S + + + Sbjct: 224 DQGLSIARMLGMLTYRTDLQLAKAFGRATKSDGSFWGDYFQVESYLSYQGKKFLERFDAN 283 Query: 449 FYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVP----QMS 504 Y+ + P Y N+ K +I +V+ D + P + Sbjct: 284 SYLHLLRALDMYDPSLGYENV--------KEALSRIKARYTLVSVTTDQLFKPIDLYKSK 335 Query: 505 QHMEDWIPHLKRGHIE-DCGHWTQMDKPTEVNQILIKWLD 543 Q +E L D GH + + + + L Sbjct: 336 QLLEQSGVDLHFYEFPSDYGHDAFLVDYDQFEKRIRDGLA 375 >6HIX-BG nrPDB Length = 378 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 27/121 (22%), Positives = 47/121 (38%), Gaps = 14/121 (11%) Query: 251 HFVELGSGPAVCLCH------GFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPE 304 H LG P + L H G E+ + + L+ V +SS Sbjct: 67 HGARLGPRPLIILDHSTKGEAGVAEAARKYESILSQLSWDYGAVYIPLHAQCTDSSKDL- 125 Query: 305 IEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMA--LFYPERVRAVASLNTPF 362 +E C+ + +D L + F+ + +G ++ MA +P RV + SL+TP Sbjct: 126 -----LEQSCQRICAVMDALDVRWTHFLTYSYGALVAVRMASSQEFPHRVGTLMSLDTPL 180 Query: 363 I 363 + Sbjct: 181 V 181 >3I6Y-A nrPDB Length = 280 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 17/72 (23%), Positives = 31/72 (43%), Gaps = 2/72 (2%) Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLDKL-GLSQAVFI-GHDWGGMLVWYMALFYPERVRA 354 + AP + + E+ ++ + +S I GH GG +AL PER ++ Sbjct: 109 NATQAPWNRHYQMYDYVVNELPELIESMFPVSDKRAIAGHSMGGHGALTIALRNPERYQS 168 Query: 355 VASLNTPFIPAN 366 V++ + P N Sbjct: 169 VSAFSPINNPVN 180 >5UNO-A nrPDB Length = 492 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 28/63 (44%) Query: 314 CKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLE 373 K++ LG + ++G+ +G + A +P+RVRA+ A+P + L Sbjct: 179 AKDLDAIRAALGDDKLTYLGYSYGTRIGSAYAEEFPQRVRAMILDGAVDPNADPIEAELR 238 Query: 374 SIK 376 K Sbjct: 239 QAK 241 >5T6O-A nrPDB Length = 389 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 35/264 (13%), Positives = 73/264 (27%), Gaps = 8/264 (3%) Query: 277 QIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDW 336 + + + G+ V + + S A ++Y + + D G + +G Sbjct: 61 LVRHVVEQGHTVFLVSWRNPDASMAGSTWDDYIEHAAIRAIEVARDISGQDKINVLGFAV 120 Query: 337 GGMLVWY----MALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGV 392 GG +V +A +V L T A+ + + + + G Sbjct: 121 GGTIVSTALAVLAARGEHPAASVTLLTTLLDFADTGILDVFVDEGHVQLREATLGGGAGA 180 Query: 393 AEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQ 452 A L S R +D + L N+P L + Sbjct: 181 PCALLRGLELANTFSFLRPND----LVWNYVVDNYLKGNTPVPFDLLFWNGDATNLPGPW 236 Query: 453 QFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIP 512 N + + I +P + + +D ++ + + Sbjct: 237 YCWYLRHTYLQNELKVPGKLTVCGVPVDLASIDVPTYIYGSREDHIVPWTAAYASTALLA 296 Query: 513 HLKRGHIEDCGHWTQMDKPTEVNQ 536 + R + GH + P N+ Sbjct: 297 NKLRFVLGASGHIAGVINPPAKNK 320 >3N2Z-B nrPDB Length = 446 Score = 39.1 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 34/125 (27%), Gaps = 8/125 (6%) Query: 245 KPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPE 304 K + F G + C+ W L A +R + S Sbjct: 36 KNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSR 95 Query: 305 IEEYCMEVLC-KEMVTFLDKLGL-------SQAVFIGHDWGGMLVWYMALFYPERVRAVA 356 + + + L + IG +GGML + + YP V Sbjct: 96 HLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGAL 155 Query: 357 SLNTP 361 + + P Sbjct: 156 AASAP 160 >6CL4-A nrPDB Length = 313 Score = 39.1 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 41/107 (38%), Gaps = 13/107 (12%) Query: 260 AVCLCHG------FPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVL 313 + L HG + + AL +AG +V + + E E L Sbjct: 29 PIVLVHGLLGFDKIGGIYPYFYGIKEALEKAGAKVYI-------ATLSALNSNELRGEQL 81 Query: 314 CKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT 360 + + + G ++ IGH G + Y+A +PE + +V S+N Sbjct: 82 LEFVRKVQAETGAAKVNLIGHSQGPLACRYVAATHPELIASVTSVNG 128 >5DWD-A nrPDB Length = 240 Score = 38.3 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 49/148 (33%), Gaps = 35/148 (23%) Query: 260 AVCLCHGFPESWYS-------WR----------YQIPALAQA---GYRVLAMDM------ 293 V L HG+ WR P + GY +D+ Sbjct: 43 LVVLLHGYGSDGRDLIALGQFWRDSFPDTMFVAPNAPHVCGGNPFGYEWFPLDLERDRTL 102 Query: 294 -KGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERV 352 + G +A P ++ + ++ + LG + + +G G M+ Y L PE + Sbjct: 103 ARLAGAETAHPVLDAFLADLWAQ------TGLGPADTILVGFSQGAMMALYTGLRLPEPL 156 Query: 353 RAVASLNTPFIPANPNMSPLESIKANPV 380 +A+ + + + P E PV Sbjct: 157 KAIIAFS--GLIVAPEKLEAEIASKPPV 182 >4Q1V-A nrPDB Length = 710 Score = 38.3 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 37/214 (17%), Positives = 65/214 (30%), Gaps = 34/214 (15%) Query: 183 LDDIGANLKPARDLGMVTILV--QDTDTALKELEKVTGIQLLNTPAPLPTSCNPSD---- 236 ++ + T L+ T + + V T A L T+ NP D Sbjct: 398 FENCKESEHSGTLSASGTYLIDRYSTKDQPRVINLVDTKNFKET-ANLLTAENPYDGYQM 456 Query: 237 --MSHGYVTVKPRVR-LHFVELGSG--------PAVCLCHGFPESWYS---WRYQI---- 278 + G + LH+ + P + +G P + W+ Sbjct: 457 PSIETGTIKAADGTTDLHYRLMKPANFDPAKKYPVIVYVYGGPHAQCVTGGWQNGARGWD 516 Query: 279 PALAQAGYRVLAMDMKGY---GESSAPPEIEEYCMEVLCKEMVTF--LDKL---GLSQAV 330 +A GY + +D +G G + +E ++ L L + Sbjct: 517 TYMASKGYIMFTIDNRGSSNRGLTFENATFRRLGIEEGKDQVKGVEFLKSLPYVDSERIG 576 Query: 331 FIGHDWGGMLVWYMALFYPERVRAVASLNTPFIP 364 G +GG + + L YPE + V P I Sbjct: 577 VHGWSFGGHMTTALMLRYPE-IFKVGVAGGPVID 609 >6OAZ-A nrPDB Length = 448 Score = 38.3 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 29/169 (17%), Positives = 55/169 (32%), Gaps = 26/169 (15%) Query: 234 PSDMSHGYVTVKPRV-----RLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYR- 287 P D + + P V HF S + HG+ + + +P L A Y+ Sbjct: 19 PEDTAEDTCHLIPGVAESVATCHFN--HSSKTFMVIHGWTVTG-MYESWVPKLVAALYKR 75 Query: 288 -----VLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLD------KLGLSQAVFIGHDW 336 V+ +D + P Y +++ +++ F++ L +G+ Sbjct: 76 EPDSNVIVVDWLSRAQ-EHYPVSAGYT-KLVGQDVARFINWMEEEFNYPLDNVHLLGYSL 133 Query: 337 GGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQL 385 G ++V + L+ PA PN E+ D Sbjct: 134 GAHAAGIAGSLTNKKVNRITGLD----PAGPNFEYAEAPSRLSPDDADF 178 >5YP1-A nrPDB Length = 745 Score = 37.9 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 37/215 (17%), Positives = 66/215 (30%), Gaps = 50/215 (23%) Query: 170 LDTLKASPSEVVFLDDIGAN-----LKPARDLG--MVTILVQDTDTALKELEKVTGIQLL 222 + + + VF+D ++ ++ + G + T+LV D A K Sbjct: 430 MHAATFARNASVFVDSWSSDTTLPQIELFKADGTKLATLLVNDVSDATHPYAK------- 482 Query: 223 NTPAPLPTSCNPSDMSHGYVTVKPRVR-LHFVELGSG--------PAVCLCHG------- 266 ++G +T LH+ + P V +G Sbjct: 483 -------YRAAHQPTAYGTLTAADGTTPLHYSLIKPAGFDPKKQYPVVVFVYGGPAAQTV 535 Query: 267 ---FPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCME--VLCKEMVTFL 321 +P S+ Q LAQ GY V +D +G A Y + V + + + Sbjct: 536 TRAWPGRSDSFFNQ--YLAQQGYVVFTLDNRGTPRRGAAFGGALYGKQGTVEVDDQLRGI 593 Query: 322 DKLGLSQAV------FIGHDWGGMLVWYMALFYPE 350 + L V G GG + + + E Sbjct: 594 EWLKSQAFVDPARIGVYGWSNGGYMTLMLLAKHDE 628 >4X97-A nrPDB Length = 380 Score = 37.9 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 23/102 (22%), Positives = 36/102 (35%), Gaps = 18/102 (17%) Query: 271 WYSWRYQIPALAQAGY------RVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKL 324 + + +L GY R D + AP E Y + + +EM+ + +L Sbjct: 103 GSYFHTMVESLVGWGYTRGEDVRGAPYDWR-----RAPNENGPYFLAL--REMIEEMYQL 155 Query: 325 GLSQAVFIGHDWGGMLVWYMALFYPE-----RVRAVASLNTP 361 V + H G M Y P+ +RA SL P Sbjct: 156 YGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAP 197 >1FJ2-A nrPDB Length = 232 Score = 37.5 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 19/124 (15%), Positives = 44/124 (35%), Gaps = 27/124 (21%) Query: 260 AVCLCHGFPESWYSWRYQIPALAQAGYRVLAM-------------------DMKGYGESS 300 AV HG ++ + W + + + + D+ G S Sbjct: 25 AVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGL---S 81 Query: 301 APPEIEEYCMEVLCKEMVTFLDK-----LGLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 + +E ++ + + +D+ + ++ + G GG L Y AL +++ V Sbjct: 82 PDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGV 141 Query: 356 ASLN 359 +L+ Sbjct: 142 TALS 145 >1GPL-A nrPDB Length = 432 Score = 37.5 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 27/161 (16%), Positives = 49/161 (30%), Gaps = 22/161 (13%) Query: 233 NPSDMSHGYVTVKPRVRL---HFVELGSGPAVCLCHGFPESWYS-WR----YQIPALAQA 284 N + S+ +T + +F + + HGF +S + W + + + Sbjct: 44 NENQNSYQLITATDIATIKASNFNL--NRKTRFIIHGFTDSGENSWLSDMCKNMFQVEKV 101 Query: 285 GYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGL------SQAVFIGHDWGG 338 + +D KG S A + V+ E+ + L IGH G Sbjct: 102 N--CICVDWKG--GSKAQYSQASQNIRVVGAEVAYLVQVLSTSLNYAPENVHIIGHSLGA 157 Query: 339 MLVWYMALFYPERVRAVASLNT--PFIPANPNMSPLESIKA 377 V + L+ P+ P L+ A Sbjct: 158 HTAGEAGKRLNGLVGRITGLDPAEPYFQDTPEEVRLDPSDA 198 >6BJE-A nrPDB Length = 222 Score = 37.2 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 21/124 (16%), Positives = 42/124 (33%), Gaps = 27/124 (21%) Query: 260 AVCLCHGFPESWYSWR--------YQIPALAQAGYRVLA-----------MDMKGYGESS 300 AV HG ++ +SW + + R+ D+ G S Sbjct: 17 AVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGL---S 73 Query: 301 APPEIEEYCMEVLCKEMVTFLDK-----LGLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 +E ++ + + ++ + ++ V G GG L Y AL P + + Sbjct: 74 PDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGI 133 Query: 356 ASLN 359 +L+ Sbjct: 134 VALS 137 >5YAL-A nrPDB Length = 342 Score = 37.2 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 33/169 (19%), Positives = 50/169 (29%), Gaps = 27/169 (15%) Query: 259 PAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDM--------KGYGESSAPPEIEEYCM 310 P V L GF S + LA GY V A+D G G ++ M Sbjct: 93 PLVVLSPGFGMSRITLTALGEDLASRGYAVAAVDHTYEAPVEFPG-GRIEKCTLCDDSRM 151 Query: 311 E------VLCKEMVTFLDKL---------GLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 + K++ LD+L + GH GG + RV A Sbjct: 152 DPGAVVRNRAKDLRFVLDRLTGPGSELRVDARRIGVAGHSIGGASAVEVMREDR-RVDAA 210 Query: 356 ASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRT 404 +L+ F P + + + EP + L+ Sbjct: 211 INLDGNFFTEPPAEGLNKPVLLLGAR--RSGLPEPQENWERAWKQLTGW 257 >6FVJ-A nrPDB Length = 261 Score = 37.2 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 28/153 (18%), Positives = 45/153 (29%), Gaps = 23/153 (15%) Query: 289 LAMDMKG-YGESSAPPEIEEYCMEVLCKEMVTFLD--KLGLSQAVFIGHDWGGMLVWYMA 345 +A+ G + S PP + L E+ + F GH GGML + +A Sbjct: 58 IAVQYPGQHDRSGLPPLE---SIPTLADEIFAMMKPSARIDDPVAFFGHSMGGMLAFEVA 114 Query: 346 LFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRT- 404 L Y V + + A + Y Q +++ E+ +R Sbjct: 115 LRYQSAGHRVLAF---------------FVSACSAPGHIRYKQLQDLSDREMLDLFTRMT 159 Query: 405 -FKSLFRASDESVLSMHKVCEAGGLFVNSPEEP 436 F DE + A P Sbjct: 160 GMNPDFFTDDEFFVGALPTLRAVRAIAGYSCPP 192 >2HO4-A nrPDB Length = 259 Score = 36.8 bits (83), Expect = 0.024, Method: Composition-based stats. Identities = 22/82 (26%), Positives = 35/82 (42%), Gaps = 7/82 (8%) Query: 159 VKPEPQIYKFLLDTLKASPSEVVFL-DDIGANLKPARDLGMVTILVQDTDTALKELEKVT 217 KPE + L +P E V + DD ++ A+++GM+ ILV+ + EK+ Sbjct: 178 GKPEKTFFLEALRDADCAPEEAVMIGDDCRDDVDGAQNIGMLGILVKTGKYKAADEEKI- 236 Query: 218 GIQLLNTPAPLPTSCNPSDMSH 239 N P L P + H Sbjct: 237 -----NPPPYLTCESFPHAVDH 253 >3HLT-A nrPDB Length = 266 Score = 36.8 bits (83), Expect = 0.029, Method: Composition-based stats. Identities = 23/82 (28%), Positives = 34/82 (41%), Gaps = 7/82 (8%) Query: 159 VKPEPQIYKFLLDTLKASPSEVVFL-DDIGANLKPARDLGMVTILVQDTDTALKELEKVT 217 KPE + L P E V + DD ++ A+D+GM+ ILV+ + EK+ Sbjct: 178 GKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKI- 236 Query: 218 GIQLLNTPAPLPTSCNPSDMSH 239 N P L P + H Sbjct: 237 -----NPPPYLTCESFPHAVDH 253 >4PNH-A nrPDB Length = 199 Score = 36.8 bits (83), Expect = 0.029, Method: Composition-based stats. Identities = 24/115 (20%), Positives = 37/115 (32%), Gaps = 14/115 (12%) Query: 103 RPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMH---------FDFLIE- 152 L+A L G+ + TN R D LKMH D + Sbjct: 48 PGSLEAIARLNHAGYRVVVATNQSGIGRGLFDMATLNAMHLKMHRAAAAVGGRIDAVFFC 107 Query: 153 ----SCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILV 203 KP P + K + + + P++ + D +L+ LG LV Sbjct: 108 PHTADDHCDCRKPMPGMMKLIAERFEIDPADTPVVGDSLRDLQAGAALGFRPHLV 162 >3FCX-A nrPDB Length = 282 Score = 36.4 bits (82), Expect = 0.031, Method: Composition-based stats. Identities = 23/140 (16%), Positives = 44/140 (31%), Gaps = 31/140 (22%) Query: 254 ELGSGPAVCLCHGFPESWYSW-----RYQIPALAQAGYRVLAMDM--KGYGESSAPPEIE 306 E G PA+ G + ++ +Q ++ G V+A D +G + Sbjct: 41 ETGKCPALYWLSGLTCTEQNFISKSGYHQSA--SEHGLVVIAPDTSPRGCNIKGEDESWD 98 Query: 307 ------------------EYCMEVLC-KEMVTFLDK---LGLSQAVFIGHDWGGMLVWYM 344 Y M +E+ ++ + + GH GG Sbjct: 99 FGTGAGFYVDATEDPWKTNYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALIC 158 Query: 345 ALFYPERVRAVASLNTPFIP 364 AL P + ++V++ P Sbjct: 159 ALKNPGKYKSVSAFAPICNP 178 >5I5F-A nrPDB Length = 586 Score = 36.4 bits (82), Expect = 0.031, Method: Composition-based stats. Identities = 21/75 (28%), Positives = 32/75 (42%), Gaps = 4/75 (5%) Query: 208 TALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGF 267 TA + LEK + L NP +S Y P LH+ ++G+G V L Sbjct: 213 TARRFLEKHGLLDAQEYQRRLVEQGNPEAVSVQY----PLSNLHYRDMGTGQNVLLITVD 268 Query: 268 PESWYSWRYQIPALA 282 ++ + Q+P LA Sbjct: 269 GLNYSRFEKQMPELA 283 >2B20-A nrPDB Length = 403 Score = 36.4 bits (82), Expect = 0.033, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 31/95 (32%), Gaps = 4/95 (4%) Query: 327 SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT----PFIPANPNMSPLESIKANPVFD 382 + V G +GG+ Y L +PER V S + P LE +KA V Sbjct: 276 DRTVVAGQSFGGLSALYAGLHWPERFGCVLSQSGSYWWPHRGGQQEGVLLEKLKAGEVSA 335 Query: 383 YQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVL 417 L + ++ + ES+ Sbjct: 336 EGLRIVLEAGIREPMIMRANQALYAQLHPIKESIF 370 >6ECE-A nrPDB Length = 303 Score = 36.4 bits (82), Expect = 0.038, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 37/115 (32%), Gaps = 9/115 (7%) Query: 256 GSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLA-MDMKGYGESSAPPEIEEYCMEVLC 314 G GP + + + L G+ + ++ G G P M C Sbjct: 36 GDGPGIVFAPPAGGTVLGYIELARHL--KGFGEIHGVEAPGLGAGETPVYPSFEEMVQFC 93 Query: 315 KEMVTFLDKLGLSQAVFIGHDWGGMLVWYMA---LFYPERVRAVASLNTPFIPAN 366 + + GH GG + +Y+A L R + + L+TP + Sbjct: 94 SDSAAGVAG---DGVYIGGHALGGHIAFYLATMLLDRGIRPKGLIILDTPPRLGD 145 >1UFO-A nrPDB Length = 238 Score = 36.0 bits (81), Expect = 0.039, Method: Composition-based stats. Identities = 22/126 (17%), Positives = 39/126 (30%), Gaps = 12/126 (9%) Query: 260 AVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPE---IEEYCMEVLCKE 316 + HG S +P A+ G+ +LA D +GE PP Y EV Sbjct: 26 LLLALHGLQGSKEHILALLPGYAERGFLLLAFDAPRHGEREGPPPSSKSPRYVEEVYRVA 85 Query: 317 MVTFLDKLGLSQ---------AVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANP 367 + + +++ G G + + +A + + F P Sbjct: 86 LGFKEEARRVAEEAERRFGLPLFLAGGSLGAFVAHLLLAEGFRPRGVLAFIGSGFPMKLP 145 Query: 368 NMSPLE 373 +E Sbjct: 146 QGQVVE 151 >6EOT-A nrPDB Length = 898 Score = 36.0 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 42/120 (35%), Gaps = 17/120 (14%) Query: 259 PAVCLCHGFPESW-------YSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEI------ 305 P V +G P+ +++ LA GY V+ +D +G E Sbjct: 663 PTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKM 722 Query: 306 EEYCMEVLCK---EMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPF 362 + ++ + + + D + L + G +GG L MAL + VA P Sbjct: 723 GQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSL-MALMQRSDIFRVAIAGAPV 781 >3FNB-A nrPDB Length = 405 Score = 36.0 bits (81), Expect = 0.041, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 54/148 (36%), Gaps = 15/148 (10%) Query: 211 KELEKVTGIQLLNTPAPLPT--SCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFP 268 + +EK+ + + N+ PL + ++ GY + + + + G Sbjct: 118 RRMEKLFMLAVDNSKIPLKSIEVPFEGELLPGYAIIS-------EDKAQDTLIVVGGGDT 170 Query: 269 ESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLD--KLGL 326 + + + Y VL +D+ G G++ P + + ++ + LD + Sbjct: 171 SREDLFYMLGYSGWEHDYNVLMVDLPGQGKN--PNQGLHFEVDARAA-ISAILDWYQAPT 227 Query: 327 SQAVFIGHDWGGMLVWYMALFYPERVRA 354 + G GG A+ +R++A Sbjct: 228 EKIAIAGFSGGGYFTAQ-AVEKDKRIKA 254 >2C4N-A nrPDB Length = 250 Score = 36.0 bits (81), Expect = 0.047, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 34/87 (39%), Gaps = 13/87 (14%) Query: 159 VKPEPQIYKFLLDTLKASPSEVVFLDDI-GANLKPARDLGMVTILVQDTDTALKELEKVT 217 KP P I + L+ ++A E V + D ++ G+ TILV ++L +++ Sbjct: 175 GKPSPWIIRAALNKMQAHSEETVIVGDNLRTDILAGFQAGLETILVLSGVSSLDDIDS-- 232 Query: 218 GIQLLNTPAPLPTSCNPSDMSHGYVTV 244 +P + S + V Sbjct: 233 ----------MPFRPSWIYPSVAEIDV 249 >4RAP-A nrPDB Length = 406 Score = 36.0 bits (81), Expect = 0.050, Method: Composition-based stats. Identities = 27/153 (17%), Positives = 50/153 (32%), Gaps = 19/153 (12%) Query: 270 SWYSWRYQIPALAQAGYRVLAMDM-----KGYGESSAPPEIEEYCMEVLCKEMVTFLDKL 324 + W I L GYRV+ +D +G+ + P E++ ++ +E V L Sbjct: 234 NGTGWSEVIAHLKSLGYRVMCIDRDAHYGQGFVWNHIPWGAEDFTGKLPLQERVNLLRHA 293 Query: 325 GLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVF--- 381 + G W A P V ++ +P + +P ++ + Sbjct: 294 SFFIGLPSGLSW-----LAWATRIP-----VVLISGFSLPNSEFYTPWRVFNSHGCYGCW 343 Query: 382 -DYQLYFQEPGVAEAELEQNLSRTFKSLFRASD 413 D L F +N R F+ + Sbjct: 344 DDTSLNFDHHDFLWCPRHKNTDRQFECTRLITG 376 >1R88-A nrPDB Length = 280 Score = 35.6 bits (80), Expect = 0.061, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 72/254 (28%), Gaps = 36/254 (14%) Query: 254 ELGSGPAVCLCHGFPESWY------------SW---RYQIPALAQAGYRVLAMDMKGYGE 298 +G V G P + Y +W + LA G V+A G Sbjct: 20 SMGRDIPVAFLAGGPHAVYLLDAFNAGPDVSNWVTAGNAMNTLAGKGISVVAP--AGGAY 77 Query: 299 S-------SAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPER 351 S + + + L + L +G GG +A F+P+R Sbjct: 78 SMYTNWEQDGSKQWDTFLSAELPDWLAA-NRGLAPGGHAAVGAAQGGYGAMALAAFHPDR 136 Query: 352 VRAVASLNTPFIPAN--PNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLF 409 S++ P+N N + ++ D + P + + Sbjct: 137 FGFAGSMSGFLYPSNTTTNGAIAAGMQQFGGVDTNGMWGAPQLGRWKWHDPWVHASLLAQ 196 Query: 410 RASDESVLSMHK--VCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYR 467 + V S + + + E SRM FY Q G G ++ Sbjct: 197 NNTRVWVWSPTNPGASDPAAMIGQAAEAMGNSRM-------FYNQYRSVGGHNGHFDFPA 249 Query: 468 NMERNWKWACKSLG 481 + + W LG Sbjct: 250 SGDNGWGSWAPQLG 263 >1PJA-A nrPDB Length = 302 Score = 35.6 bits (80), Expect = 0.061, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 46/105 (43%), Gaps = 7/105 (6%) Query: 260 AVCLCHGFPESWYSWRYQIPALAQA--GYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEM 317 V + HG +S YS+R+ + + + G V +D+ G S P E+ ++ + + Sbjct: 38 PVIVVHGLFDSSYSFRHLLEYINETHPGTVVTVLDLF-DGRESLRPLWEQ--VQGFREAV 94 Query: 318 VTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPER-VRAVASLNTP 361 V + K I + GG++ + + V + SL++P Sbjct: 95 VPIMAKAPQG-VHLICYSQGGLVCRALLSVMDDHNVDSFISLSSP 138 >2RON-A nrPDB Length = 242 Score = 35.6 bits (80), Expect = 0.062, Method: Composition-based stats. Identities = 34/180 (18%), Positives = 65/180 (36%), Gaps = 14/180 (7%) Query: 268 PESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLS 327 S+R + A Q +LA + G+G + + +E L L+ Sbjct: 23 GGYSASFRP-LHAFLQGECEMLAAEPPGHGTNQTSAIED---LEELTDLYKQELNLRPDR 78 Query: 328 QAVFIGHDWGGMLVWYMALF-YPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLY 386 V GH GGM+ + +A E + A + + P + + + P + + Sbjct: 79 PFVLFGHSMGGMITFRLAQKLEREGIFPQAVIISAIQPPHIQ---RKKVSHLPDDQFLDH 135 Query: 387 FQEPGVAEAELEQN------LSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR 440 + G AEL +N +F+S +RA ++ L ++ N ++ R Sbjct: 136 IIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIR 195 >2PPL-A nrPDB Length = 485 Score = 35.6 bits (80), Expect = 0.065, Method: Composition-based stats. Identities = 38/237 (16%), Positives = 71/237 (29%), Gaps = 23/237 (9%) Query: 262 CLCHGFPESWY-SWRYQI--PALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMV 318 + HGF + SW + + +D K S A + V+ ++ Sbjct: 99 FIIHGFIDKGDESWVTDMCKKLFEVEEVNCICVDWK--KGSQATYTQAANNVRVVGAQVA 156 Query: 319 TFLDKL------GLSQAVFIGHDWGGMLVWYMALFYP--ERVRAVASLNTPFIPANPNMS 370 LD L S+ IGH G + P R+ + + F + P Sbjct: 157 QMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASF-ESTPEEV 215 Query: 371 PLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFV 430 L+ A+ V D P + N F ES+ K + + + Sbjct: 216 RLDPSDADFV-DVIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGESMPGCKKNALSQIVDL 274 Query: 431 N----SPEEPSLSRMVTEEEIQFYVQQFKKSGFRG--PLNWYRNMERNWKWACKSLG 481 + + + ++Y++ P Y++ E + + C G Sbjct: 275 DGIWAGTRDFVACNHL--RSYKYYLESILNPDGFAAYPCTSYKSFESDKCFPCPDQG 329 >1BU8-A nrPDB Length = 452 Score = 35.2 bits (79), Expect = 0.078, Method: Composition-based stats. Identities = 33/206 (16%), Positives = 59/206 (28%), Gaps = 15/206 (7%) Query: 288 VLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLS------QAVFIGHDWGGMLV 341 + +D + S Y V+ E+ + L IGH G +V Sbjct: 103 CICVDWR--RGSRTEYTQASYNTRVVGAEIAFLVQVLSTEMGYSPENVHLIGHSLGAHVV 160 Query: 342 WYMALFYPERVRAVASLNT--PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQ 399 V + L+ P P L+ A V D P + Sbjct: 161 GEAGRRLEGHVGRITGLDPAEPCFQGLPEEVRLDPSDAMFV-DVIHTDSAPIIPYLGFGM 219 Query: 400 NLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTE--EEIQFYVQQFKKS 457 + F + + K + + +N E + + + ++Y Sbjct: 220 SQKVGHLDFFPNGGKEMPGCQKNILSTIVDINGIWEGTQNFVACNHLRSYKYYASSILNP 279 Query: 458 -GFRG-PLNWYRNMERNWKWACKSLG 481 GF G P + Y ++N + C G Sbjct: 280 DGFLGYPCSSYEKFQQNDCFPCPEEG 305 >4B6G-A nrPDB Length = 283 Score = 34.8 bits (78), Expect = 0.089, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 39/106 (36%), Gaps = 8/106 (7%) Query: 290 AMDM---KGY--GESSAPPEIEEYCMEVLCKEMVTFLDKL--GLSQAVFIGHDWGGMLVW 342 A D+ G+ + P + + E+ ++K + +GH GG Sbjct: 101 AYDLGQSAGFYLNATEQPWAANYQMYDYILNELPRLIEKHFPTNGKRSIMGHSMGGHGAL 160 Query: 343 YMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQ 388 +AL ER ++ S +P + + ++ A D + + Q Sbjct: 161 VLALRNQERYQS-VSAFSPILSPSLVPWGEKAFTAYLGKDREKWQQ 205 >5BV7-A nrPDB Length = 422 Score = 34.8 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 37/228 (16%), Positives = 69/228 (30%), Gaps = 34/228 (14%) Query: 238 SHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGY------RVLAM 291 S G V+ P V++ G +V + Y + L GY R Sbjct: 86 SSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYL-HTLVQNLVNNGYVRDETVRAAPY 144 Query: 292 DMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLS---QAVFIGHDWGGMLVWYMALFY 348 D + +E E +++ ++++ + IGH G + + Y L Sbjct: 145 DWR----------LEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQ 194 Query: 349 PE-----RVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSR 403 P+ + SL P+ SIK V P ++ +L++ Sbjct: 195 PQAWKDRFIDGFISLGAPWGG---------SIKPMLVLASGDNQGIPIMSSIKLKEEQRI 245 Query: 404 TFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYV 451 T S + V + F + + E +Y+ Sbjct: 246 TTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYM 293 >3LCR-A nrPDB Length = 319 Score = 34.8 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 46/138 (33%), Gaps = 11/138 (7%) Query: 278 IPALAQAGYRVLAMDMKG-YGESSAPPEIEEYCMEVLCKEMVTFLDK-LGLSQAVFIGHD 335 + AG RV A+ G +G + P + VL + + + + + GH Sbjct: 102 LAEELDAGRRVSALVPPGFHGGQALPA-----TLTVLVRSLADVVQAEVADGEFALAGHS 156 Query: 336 WGGMLVWYMALFYPERV---RAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGV 392 GG++ + +A R R V +++ + P E ++ + Y + G Sbjct: 157 SGGVVAYEVARELEARGLAPRGVVLIDSYSFDGD-GGRPEELFRSALNERFVEYLRLTGG 215 Query: 393 AEAELEQNLSRTFKSLFR 410 L R Sbjct: 216 GNLSQRITAQVWCLELLR 233 >1PW5-A nrPDB Length = 253 Score = 34.8 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 13/62 (20%), Positives = 30/62 (48%), Gaps = 1/62 (1%) Query: 155 QVGMVKPEPQIYKFLLDTLKASPSEVVFLDD-IGANLKPARDLGMVTILVQDTDTALKEL 213 + KP P + + + + + D + ++K ++ G+V+ILV +T ++L Sbjct: 178 DLIAGKPNPLVVDVISEKFGVPKERMAMVGDRLYTDVKLGKNAGIVSILVLTGETTPEDL 237 Query: 214 EK 215 E+ Sbjct: 238 ER 239 >6BA9-A nrPDB Length = 263 Score = 34.1 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 25/188 (13%), Positives = 57/188 (30%), Gaps = 15/188 (7%) Query: 358 LNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVL 417 L P P + ++ A F+ ++ G+A L + + S+ + Sbjct: 74 LEASVSPDTPLLLAGHAMGAQVAFETCRLLEQRGLAPQGL---IISGCHAPHLHSERQLS 130 Query: 418 SMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWAC 477 L P L +E+ ++ F ++ + Sbjct: 131 HRDDADFIAELIDIGGCSPELRE---NQELMSLFLPLLRADFYATESY--------HYDS 179 Query: 478 KSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKP-TEVNQ 536 + + PAL++ D Q W+ H+ + D H+ + + + Q Sbjct: 180 PDVCPPLRTPALLLCGSHDREASWQQVDAWRQWLSHVTGPVVIDGDHFYPIQQARSFFTQ 239 Query: 537 ILIKWLDS 544 I+ + + Sbjct: 240 IVRHFPHA 247 >5I5H-A nrPDB Length = 586 Score = 34.1 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 15/51 (29%), Positives = 24/51 (47%), Gaps = 4/51 (7%) Query: 233 NPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQ 283 NP +S Y P L + ++G+G V L ++ + Q+PALA Sbjct: 238 NPDAVSVQY----PLSELRYRDMGTGQNVLLITVDGLNYSRFEKQMPALAG 284 >2X4D-A nrPDB Length = 271 Score = 33.7 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 17/70 (24%), Positives = 33/70 (47%), Gaps = 4/70 (5%) Query: 139 LMCELKMHFDFLIESCQVG---MVKPEPQIYKFLLDTLKASPSEVVFL-DDIGANLKPAR 194 LM ++ + L +C + + KP P+ +K L + + V + DDI ++ A+ Sbjct: 166 LMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIGVEAHQAVMIGDDIVGDVGGAQ 225 Query: 195 DLGMVTILVQ 204 GM + V+ Sbjct: 226 RCGMRALQVR 235 >1DQU-A nrPDB Length = 538 Score = 33.7 bits (75), Expect = 0.23, Method: Composition-based stats. Identities = 28/157 (17%), Positives = 51/157 (32%), Gaps = 10/157 (6%) Query: 53 LMKGE--ITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAAL 110 + +G I + P +KC A L I E ++ ++ R M L Sbjct: 187 VERGAAGIHIEDQAP----GTKKCGHMAGKVL---VPISEHINRLVAIRAQADIMGTDLL 239 Query: 111 MLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQ-IYKFL 169 + + A L + +D R + +++ D ++ + Q G E Q I Sbjct: 240 AIARTDSEAATLITSTIDHRDHPFIIGSTNPDIQPLNDLMVMAEQAGKNGAELQAIEDEW 299 Query: 170 LDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDT 206 L +D I + P + + L Q Sbjct: 300 LAKAGLKLFNDAVVDAINNSPLPNKKAAIEKYLTQSK 336 >6EOR-A nrPDB Length = 869 Score = 33.7 bits (75), Expect = 0.23, Method: Composition-based stats. Identities = 25/124 (20%), Positives = 40/124 (32%), Gaps = 25/124 (20%) Query: 259 PAVCLCHGFPE--------SWYSWRYQIPALAQAGYRVLAMDMKGY------------GE 298 P V +G P+ + + LA GY V+ +D +G + Sbjct: 638 PTVLFVYGGPQVQLVNNSFKGIKYLR-LNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQ 696 Query: 299 SSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASL 358 ++ E F+D LS+ G +GG L + P+ V VA Sbjct: 697 MGQVEIEDQVEGLQFVAEKYGFID---LSRVAIHGWSYGGFLSLMGLIHKPQ-VFKVAIA 752 Query: 359 NTPF 362 P Sbjct: 753 GAPV 756 >1ETH-A nrPDB Length = 448 Score = 33.3 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 38/235 (16%), Positives = 68/235 (28%), Gaps = 18/235 (7%) Query: 262 CLCHGFPESWY-SWRYQI--PALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMV 318 + HGF + W I + +D KG S + ++ E+ Sbjct: 73 FIIHGFIDKGEEDWLSNICKNLFKVESVNCICVDWKG--GSRTGYTQASQNIRIVGAEVA 130 Query: 319 TFLDKLGLS------QAVFIGHDWGGMLVWYMALFYPERVRAVASLNT--PFIPANPNMS 370 F++ L S IGH G + + L+ P P + Sbjct: 131 YFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAEPCFQGTPELV 190 Query: 371 PLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFV 430 L+ A V D P + + + F + + K + + + Sbjct: 191 RLDPSDAKFV-DVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQKNILSQIVDI 249 Query: 431 NSPEEPSLSRMVTE--EEIQFYVQQFKKS-GFRG-PLNWYRNMERNWKWACKSLG 481 + E + + ++Y GF G P + Y N + C S G Sbjct: 250 DGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPCPSEG 304 >5KRE-A nrPDB Length = 239 Score = 32.9 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 48/129 (37%), Gaps = 32/129 (24%) Query: 261 VCLCHGFPESW---YSWRYQI--PALAQAGYRVLAMD--------MKGYGES-------- 299 + HG +S W Q+ L +++ MKG G S Sbjct: 26 LIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPTAPPRSYTPMKG-GISNVWFDRFK 84 Query: 300 ---SAPPEIEEYCMEVLCKEMVTFLD---KLGLSQAVFI--GHDWGGMLVWYMALFYPER 351 P +E ++V+C+ + +D K G+ + + G GG + ++A + Sbjct: 85 ITNDCPEHLE--SIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAMHLAYRNHQD 142 Query: 352 VRAVASLNT 360 V V +L++ Sbjct: 143 VAGVFALSS 151 >3QMW-A nrPDB Length = 259 Score = 32.9 bits (73), Expect = 0.39, Method: Composition-based stats. Identities = 26/181 (14%), Positives = 53/181 (29%), Gaps = 9/181 (4%) Query: 288 VLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQ-AVFIGHDWGGMLVWYMA- 345 V+ + + G G E ME L + + L++ L+ GH G +L + +A Sbjct: 59 VVPVQLPGRGL--RLRERPYDTMEPLAEAVADALEEHRLTHDYALFGHSMGALLAYEVAC 116 Query: 346 ---LFYPERVRAVASLNT--PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQN 400 R R + + P + + L V + A Sbjct: 117 VLRRRGAPRPRHLFVSGSRAPHLYGDRADHTLSDTALREVIRDLGGLDDADTLGAAYFDR 176 Query: 401 LSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFR 460 ++ RA + + ++ +P + + E + F + Sbjct: 177 RLPVLRADLRACERYDWHPRPPLDCPTTAFSAAADPIATPEMVEAWRPYTTGSFLRRHLP 236 Query: 461 G 461 G Sbjct: 237 G 237 >1WDT-A nrPDB Length = 665 Score = 32.5 bits (72), Expect = 0.43, Method: Composition-based stats. Identities = 48/307 (15%), Positives = 96/307 (31%), Gaps = 55/307 (17%) Query: 278 IPALAQAGYRVLAMDMKGYG-------------ESSAPPEIEEYCMEVLCKEMVTFLDKL 324 + L G+RV +D GYG +++ E ++V + T ++L Sbjct: 66 VAPLLFRGHRVFLLDAPGYGDFVGEIRGALEAADAALVAVSAEAGVQVGTERAWTVAERL 125 Query: 325 GLSQAVFI-----GHD-----------WGGMLVWYMALFYPERVRAVASLNTPFIPANPN 368 GL + V + G D G +L + L+ + + + N Sbjct: 126 GLPRMVVVTKLDKGGDYYALLEDLRSTLGPILPIDLPLYEGGKWVGLIDVFHGKAYRYEN 185 Query: 369 MSPLES-IKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGG 427 E+ + Q + QE A E ++ L + + E++ G Sbjct: 186 GEEREAEVPPEERERVQRFRQEVLEAIVETDEGLLEKYLEGEEVTGEALEKAFHEAVRRG 245 Query: 428 L-----FVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERN---------- 472 L + E + + E ++ ++ G PL ++ + Sbjct: 246 LLYPVALASGEREIGVL-PLLELILEALPSPTERFGDGPPLAKVFKVQVDPFMGQVAYLR 304 Query: 473 -------WKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHW 525 + +S ++ +P L V KD + V + +P + H Sbjct: 305 LYRGRLKPGDSLQSEAGQVRLPHLYVPMGKDLLEVEEAEAGFVLGVPKAEGLHRGMV--L 362 Query: 526 TQMDKPT 532 Q +KP Sbjct: 363 WQGEKPE 369 >2PVS-A nrPDB Length = 452 Score = 32.5 bits (72), Expect = 0.47, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 27/91 (29%), Gaps = 11/91 (12%) Query: 262 CLCHGFPESW-YSWRYQI--PALAQAGYRVLAMDMKGYG----ESSAPPEIEEYCMEVLC 314 + HGF + SW + + +D + +G + A I E Sbjct: 74 FIIHGFLDKAEDSWPSDMCKKMFEVEKVNCICVDWR-HGSRAMYTQAVQNIRVVGAET-A 131 Query: 315 KEMVTFLDKLG--LSQAVFIGHDWGGMLVWY 343 + +LG L IGH G Sbjct: 132 FLIQALSTQLGYSLEDVHVIGHSLGAHTAAE 162 >3LS2-A nrPDB Length = 280 Score = 32.5 bits (72), Expect = 0.49, Method: Composition-based stats. Identities = 12/72 (16%), Positives = 27/72 (37%), Gaps = 2/72 (2%) Query: 297 GESSAPPEIEEYCMEVLCKEMVTFLDK-LGLSQ-AVFIGHDWGGMLVWYMALFYPERVRA 354 + AP + + E+ +++ ++ GH GG +AL P+ + Sbjct: 107 NATQAPYNTHFNMYDYVVNELPALIEQHFPVTSTKAISGHSMGGHGALMIALKNPQDYVS 166 Query: 355 VASLNTPFIPAN 366 ++ + P N Sbjct: 167 ASAFSPIVNPIN 178 >2ECF-A nrPDB Length = 741 Score = 32.1 bits (71), Expect = 0.67, Method: Composition-based stats. Identities = 51/305 (16%), Positives = 95/305 (31%), Gaps = 37/305 (12%) Query: 75 SETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDR---- 130 ET+ +P + S+ D R Q + KG A+ W D Sbjct: 329 HETSPTWVPLHNSL-RFLDDGSILWSSERTGFQHLYRIDSKGKAAALTHGNWSVDELLAV 387 Query: 131 AERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANL 190 E+ GLA ++ + I + + +P+ + + + + V++D N Sbjct: 388 DEKAGLAYFRAGIESARESQIYAVPLQGGQPQRLSKAPGMHSASFARNASVYVDSWSNNS 447 Query: 191 KP-------ARDLGMVTILVQD----TDTALKELEKVTGIQLLN-TPAPLPTSCNPSDMS 238 P A + T++ D + E ++ T A T N S + Sbjct: 448 TPPQIELFRANGEKIATLVENDLADPKHPYARYREAQRPVEFGTLTAADGKTPLNYSVIK 507 Query: 239 HGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGE 298 R + G + + +P Q LAQ GY V ++D +G Sbjct: 508 PAGFDPAKRYPVAVYVYGGPASQTVTDSWPGRGDHLFNQ--YLAQQGYVVFSLDNRG--- 562 Query: 299 SSAPPEIEEYCMEVLCKE-MVTFLDKL------------GLSQAVFIGHDWGGMLVWYMA 345 P ++ + K+ V D+L ++ G GG + + Sbjct: 563 --TPRRGRDFGGALYGKQGTVEVADQLRGVAWLKQQPWVDPARIGVQGWSNGGYMTLMLL 620 Query: 346 LFYPE 350 + Sbjct: 621 AKASD 625 >4GBT-A nrPDB Length = 735 Score = 32.1 bits (71), Expect = 0.67, Method: Composition-based stats. Identities = 12/70 (17%), Positives = 24/70 (34%), Gaps = 4/70 (5%) Query: 226 APLPTSCNPSDMSHGYVTVKPRVRLHFVELGS--GPAVCLCHGFP--ESWYSWRYQIPAL 281 AP+ N + + + R +H+ + + GP H P + W ++ Sbjct: 565 APISIPPNQNQILQREDAIAGRTNMHYTNVFNSYGPLSAFPHPDPIYPNGQIWDKELDLE 624 Query: 282 AQAGYRVLAM 291 + V A Sbjct: 625 HKPRLHVTAP 634 >2BHS-A nrPDB Length = 303 Score = 32.1 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 8/56 (14%), Positives = 22/56 (39%), Gaps = 2/56 (3%) Query: 310 MEVLCKEMVTFLDKLGLSQAVFIGHDWGGML--VWYMALFYPERVRAVASLNTPFI 363 +++ ++ + +L + + +F G GG + +A P+ V + Sbjct: 230 LDIHQRDAENTMRELAVREGIFCGVSSGGAVAGALRVAKANPDAVVVAIICDRGDR 285 >3PDW-A nrPDB Length = 266 Score = 31.8 bits (70), Expect = 0.82, Method: Composition-based stats. Identities = 17/64 (26%), Positives = 27/64 (42%), Gaps = 5/64 (7%) Query: 159 VKPEPQIYKFLLDTLKASPSEVVFLDDI-GANLKPARDLGMVTILVQDTDT----ALKEL 213 KPE I + + L SE + + D ++ + GM T+LV T ++ Sbjct: 182 GKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGVTKREHMTDDM 241 Query: 214 EKVT 217 EK T Sbjct: 242 EKPT 245 >1W52-X nrPDB Length = 452 Score = 31.8 bits (70), Expect = 0.86, Method: Composition-based stats. Identities = 25/160 (15%), Positives = 43/160 (26%), Gaps = 19/160 (11%) Query: 221 LLNTPAPLPTSC-----------NPSDMSHGYVTVKPRVRLHFVELGSGPAVCL-CHGFP 268 L LP S N + S+ +T + + S HGF Sbjct: 21 LQRPLKSLPWSPEEVNTRFLLYTNKNPDSYQLITARDVATIKSSNFQSSRKTHFVIHGFR 80 Query: 269 ESW-YSWRYQI--PALAQAGYRVLAMDMKGYGESSAPPEIEEYCM--EVLCKEMVTFLDK 323 + SW + L +++D ++ ++ + + L + Sbjct: 81 DRGEDSWPSDMCKKILQVETTNCISVDWSSGAKAEYTQAVQNIRIVGAETAYLIQQLLTE 140 Query: 324 LGL--SQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTP 361 L IGH G RV V L+ Sbjct: 141 LSYNPENVHIIGHSLGAHTAGEAGRRLEGRVGRVTGLDPA 180 >4MQM-A nrPDB Length = 304 Score = 31.8 bits (70), Expect = 0.92, Method: Composition-based stats. Identities = 33/136 (24%), Positives = 52/136 (38%), Gaps = 24/136 (17%) Query: 256 GSGP-AVCLCHGF-PESWYS-WRYQIPALA---QAGYRVLAMDMKGYGESSAPPEIEE-- 307 G GP AV L G + Y+ W PA Q+G V+ G G+SS + + Sbjct: 30 GGGPHAVYLLDGLRAQDDYNGWDINTPAFEEYYQSGLSVIMP--VG-GQSSFYTDWYQPS 86 Query: 308 --------YCMEVL-CKEMVTFLDK---LGLSQAVFIGHDWGGMLVWYMALFYPERVRAV 355 Y E +EM +L + + +G G +A +YP++ Sbjct: 87 QSNGQNYTYKWETFLTREMPAWLQANKGVSPTGNAAVGLSMSGGSALILAAYYPQQFPYA 146 Query: 356 ASLNTPFIPANPNMSP 371 ASL + F+ + P Sbjct: 147 ASL-SGFLNPSEGWWP 161 >3AZQ-A nrPDB Length = 662 Score = 31.4 bits (69), Expect = 0.98, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 21/59 (35%), Gaps = 4/59 (6%) Query: 470 ERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHL----KRGHIEDCGH 524 ER A + ++ +P L++ +D V P+ + + E GH Sbjct: 567 ERYRDRAPLTRADRVRVPFLLLQGLEDPVCPPEQCDRFLEAVAGCGVPHAYLSFEGEGH 625 >4R1D-A nrPDB Length = 569 Score = 31.4 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 19/162 (11%), Positives = 50/162 (30%), Gaps = 9/162 (5%) Query: 322 DKLGLSQAVFIGHDWGGMLVWYMALFYP-ERVRAVASLNTPFIPANPNMSPLESIKANPV 380 +++ + + + H GG++ + + ERV V PA + + ++ Sbjct: 243 EQMRRMKVILVTHSMGGLVARALTQLHGYERVLGVVH---GVQPATGSSTIYHHMRCGYE 299 Query: 381 FDYQLYFQEPGVAEAELEQNLSRTFKSLFRA-SDESVLSMHKVCEAGGLFVNSPEEPSLS 439 Q+ + N + + A E + G + + +P Sbjct: 300 GIAQVVLGRNAGEVTAIVANSAGALELAPSAEYREGRPWLFLCDAQGQVLKDIDGKPRA- 358 Query: 440 RMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLG 481 + Y + +K + + G + + + + L Sbjct: 359 ---YPQNQDPYEEIYKNTTWYGLVPEQNSQYLDMSDKKEGLR 397 >5LZ5-A nrPDB Length = 388 Score = 31.4 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 18/59 (30%), Gaps = 5/59 (8%) Query: 259 PAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEM 317 P V HG + LA G+ V A++ + Y + E+ Sbjct: 100 PLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR-----DRSASATYYFKDQSAAEI 153 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 27/76 (35%), Gaps = 3/76 (3%) Query: 316 EMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESI 375 +M D + + IGH +GG V L +R R +L+ P + I Sbjct: 209 DMEQLKDSIDREKIAVIGHSFGGATVIQ-TLSEDQRFRCGIALDAWMFPLGDEVYSR--I 265 Query: 376 KANPVFDYQLYFQEPG 391 F YFQ P Sbjct: 266 PQPLFFINSEYFQYPA 281 >6GI5-A nrPDB Length = 282 Score = 31.0 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 36/103 (34%), Gaps = 20/103 (19%) Query: 279 PALAQAGYRV-LAMDMKGY---------GESSA-------PPEIEEYCMEVLCKEMVTFL 321 P L GYR L +D G G++ P + +++L M + Sbjct: 84 PLLVAIGYRTPLRIDRAGRTFDYTPASPGQADQRDPLNGLPSGGADAFLDLLRDGMRPAV 143 Query: 322 DK---LGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTP 361 L ++ GH +GG+LV + P A+ + Sbjct: 144 AAQAPLDTARQTLWGHSYGGLLVLHALFTRPGEFARYAAASPS 186 >1RP1-A nrPDB Length = 450 Score = 31.0 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 37/237 (15%), Positives = 68/237 (28%), Gaps = 23/237 (9%) Query: 262 CLCHGFPESWY-SWR----YQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKE 316 + HGF + +W + + + + +D K S + V+ + Sbjct: 74 FIIHGFIDKGEENWLLDMCKNMFKVEEVN--CICVDWK--KGSQTSYTQAANNVRVVGAQ 129 Query: 317 MVTFLDKLGL------SQAVFIGHDWGGMLVWYMALFYP--ERVRAVASLNTPFIPANPN 368 + L L SQ IGH G + P R+ + + F P Sbjct: 130 VAQMLSMLSANYSYSPSQVQLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEASF-QGTPE 188 Query: 369 MSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGL 428 L+ A+ V D P + + F E + K + + Sbjct: 189 EVRLDPTDADFV-DVIHTDAAPLIPFLGFGTSQQMGHLDFFPNGGEEMPGCKKNALSQIV 247 Query: 429 FVNSPEEPSLSRMVTE--EEIQFYVQQFKKSGFRG--PLNWYRNMERNWKWACKSLG 481 ++ E + + ++Y + P YR E N + C G Sbjct: 248 DLDGIWEGTRDFVACNHLRSYKYYSESILNPDGFASYPCASYRAFESNKCFPCPDQG 304 >3OOQ-A nrPDB Length = 396 Score = 31.0 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 29/159 (18%), Positives = 63/159 (39%), Gaps = 14/159 (8%) Query: 51 TRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINR------- 103 ++ GE+ L + IP R + + + F + + A KI++ Sbjct: 208 LKMEVGEMVLRKKIPARMHAHRADDILTAIRIAEEFGFNLVIEHGTEAYKISKVLAEKKI 267 Query: 104 PMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCE---LKMHFDFLIESCQVGMVK 160 P++ L+ + LT + + L LMC+ + + F + + + Sbjct: 268 PVVVGPLLTFRTKLELKDLTMETIAKLLKDGVLIALMCDHPVIPLEFATVQAATAMRYGA 327 Query: 161 PEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMV 199 E LL L +P++++ L+D +++P +D +V Sbjct: 328 KEED----LLKILTVNPAKILGLEDRIGSIEPGKDADLV 362 >6AVW-A nrPDB Length = 230 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 32/88 (36%), Gaps = 7/88 (7%) Query: 303 PEIEEYCMEVLCKEMVTFLDKL-----GLSQAVFIGHDWGGMLVWYMALFYPERVRAVAS 357 I+E + K + +D+ G GG L L YP+ + A Sbjct: 71 SPIDESSVLEAVKNVHAIIDQEIAEGTNPENVFICGLSQGGALTLASVLLYPKTLGGGAV 130 Query: 358 LNT--PFIPANPNMSPLESIKANPVFDY 383 L+ PF + + P E+ K ++ + Sbjct: 131 LSGWVPFTSSIISQFPEEAKKTPILWSH 158 >3MGA-A nrPDB Length = 407 Score = 29.8 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 30/97 (30%), Gaps = 4/97 (4%) Query: 325 GLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT----PFIPANPNMSPLESIKANPV 380 + V G +GG+ Y L +P R V S + P P + +K + Sbjct: 279 DAGRTVVAGQSFGGLSALYAGLNWPTRFGCVLSQSGSFWWPHRITPPEGEVITRLKTGAL 338 Query: 381 FDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVL 417 L + ++ + S +S+ Sbjct: 339 CARGLRIVLEAGVREPIVFQANQALYAQLNTSQQSIF 375 >2WAA-A nrPDB Length = 347 Score = 29.8 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 18/140 (12%), Positives = 51/140 (36%), Gaps = 4/140 (2%) Query: 415 SVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWK 474 +++ ++ G F+ +P P +V + + + +G W+ E Sbjct: 110 GQVTLKQLTLTGTQFLPAPVLPQRKILVLGDSVTCGEAIDRVAGEDKNTRWWNARESYGM 169 Query: 475 WACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEV 534 K+L ++ L+ + ++ + + +P + + D G Q D Sbjct: 170 LTAKALDAQVQ---LVCWGGRG-LIRSWNGKTDDANLPDFYQFTLGDTGQAPQWDHHRYQ 225 Query: 535 NQILIKWLDSDARNPPVVSK 554 ++I + ++ +P + + Sbjct: 226 PDLIISAIGTNDFSPGIPDR 245 >5LV0-A nrPDB Length = 686 Score = 29.8 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 26/68 (38%), Gaps = 3/68 (4%) Query: 101 INRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLA-QLMCELKMHFDFLIESCQVGMV 159 + R ML + +T D R R + + ++ L E+C +G + Sbjct: 83 VERTMLDFPQHVSSD--KEVRAASTEADKRLSRFDIEMSMRGDIFERIVHLQETCDLGKI 140 Query: 160 KPEPQIYK 167 KPE + Y Sbjct: 141 KPEARRYL 148 >3CUQ-C nrPDB Length = 176 Score = 29.1 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 6/39 (15%), Positives = 15/39 (38%) Query: 513 HLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPV 551 +L+ +P E +++ +W+ +N V Sbjct: 86 NLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSV 124 >5LFZ-A nrPDB Length = 223 Score = 29.1 bits (63), Expect = 5.8, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 28/69 (40%), Gaps = 2/69 (2%) Query: 245 KPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPA-LAQAGYRVLAMDMKGYGESSAPP 303 + VR+ E G + L H ES Q+ + L AGY ++ +D G P Sbjct: 154 QKTVRIALEEAKPGS-IILMHDIHESSVKAVPQLVSKLHDAGYTLVTVDQLFAGTDFKPA 212 Query: 304 EIEEYCMEV 312 + ++ + Sbjct: 213 KAYDHRFKT 221 >3CN7-A nrPDB Length = 226 Score = 28.7 bits (62), Expect = 6.3, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 52/149 (34%), Gaps = 31/149 (20%) Query: 261 VCLCHGFPESWYSWRYQIPALA-----------QAGYRVLA----------MDMKGYGES 299 + HG ++ AL QA + + D+ + Sbjct: 27 IIWLHGLGADRTDFKPVAEALQMVLPSTRFILPQAPSQAVTVNGGWVMPSWYDILAF--- 83 Query: 300 SAPPEIEEYCMEVLCKEMVTFLDK-----LGLSQAVFIGHDWGGMLVWYMA-LFYPERVR 353 S I+E + +++ +D+ + + + G GG +V + A Y + + Sbjct: 84 SPARAIDEDQLNASADQVIALIDEQRAKGIAAERIILAGFSQGGAVVLHTAFRRYAQPLG 143 Query: 354 AVASLNTPFIPANPNMSPLESIKANPVFD 382 V +L+T + P +++ E K PV Sbjct: 144 GVLALST-YAPTFDDLALDERHKRIPVLH 171 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.118 0.293 Lambda K H 0.267 0.0360 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,174,997 Number of Sequences: 36641 Number of extensions: 698041 Number of successful extensions: 2404 Number of sequences better than 10.0: 191 Number of HSP's better than 10.0 without gapping: 174 Number of HSP's successfully gapped in prelim test: 104 Number of HSP's that attempted gapping in prelim test: 1953 Number of HSP's gapped (non-prelim): 331 length of query: 555 length of database: 10,336,785 effective HSP length: 102 effective length of query: 453 effective length of database: 6,599,403 effective search space: 2989529559 effective search space used: 2989529559 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.3 bits)