BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P34059 (522 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4FDJ-A nrPDB 1028 0.0 1E2S-P nrPDB 253 2e-67 6BIA-A nrPDB 208 6e-54 1FSU-A nrPDB 161 8e-40 1P49-A nrPDB 154 7e-38 3ED4-A nrPDB 148 6e-36 4CXU-A nrPDB 121 8e-28 2QZU-A nrPDB 106 2e-23 5G2V-A nrPDB 96 3e-20 4MHX-A nrPDB 77 2e-14 6IOZ-A nrPDB 65 8e-11 4UPL-A nrPDB 59 4e-09 4UG4-A nrPDB 58 1e-08 5G2T-A nrPDB 56 4e-08 2W8S-A nrPDB 52 5e-07 4UPI-A nrPDB 52 6e-07 4UPH-A nrPDB 50 2e-06 2VQR-A nrPDB 50 3e-06 4UPK-A nrPDB 40 0.003 4UOP-A nrPDB 38 0.014 5I5H-A nrPDB 37 0.024 5I5F-A nrPDB 35 0.064 5XWI-A nrPDB 34 0.13 3C0Q-A nrPDB 31 1.1 5OLB-A nrPDB 31 1.5 4LZI-A nrPDB 30 2.5 4LR2-A nrPDB 30 3.6 5UDY-A nrPDB 28 7.2 3D1Q-A nrPDB 28 7.5 5VEN-A nrPDB 28 9.4 >4FDJ-A nrPDB Length = 502 Score = 1028 bits (2658), Expect = 0.0, Method: Compositional matrix adjust. Identities = 495/496 (99%), Positives = 495/496 (99%) Query: 27 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAAL 86 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPL SPSRAAL Sbjct: 1 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAAL 60 Query: 87 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 146 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR Sbjct: 61 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 120 Query: 147 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT 206 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT Sbjct: 121 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT 180 Query: 207 QIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIG 266 QIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIG Sbjct: 181 QIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIG 240 Query: 267 KILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWW 326 KILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWW Sbjct: 241 KILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWW 300 Query: 327 PGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYR 386 PGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYR Sbjct: 301 PGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYR 360 Query: 387 GDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGR 446 GDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGR Sbjct: 361 GDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGR 420 Query: 447 DPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGK 506 DPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGK Sbjct: 421 DPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGK 480 Query: 507 CLTPPESIPKKCLWSH 522 CLTPPESIPKKCLWSH Sbjct: 481 CLTPPESIPKKCLWSH 496 >1E2S-P nrPDB Length = 489 Score = 253 bits (645), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 173/446 (38%), Positives = 240/446 (53%), Gaps = 43/446 (9%) Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 +PPNI+L+ DD+G+GDLG YG PS TPNLD++AA GL F +FY L +PSRAALLT Sbjct: 1 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLATPSRAALLT 60 Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148 GRLP+R G Y P GG+P E + E+L GY++ + GKWHLG P+ Sbjct: 61 GRLPVRMGMYP------GVLVPSS-RGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPE 113 Query: 149 --FHPLKHGFDEWFGSPNCHF-GPYDNKA--RPNIPVYRDWEMVGRYYEEFPINLKTGEA 203 F P GF + G P H GP N P P + G NL EA Sbjct: 114 GAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQ-GLVPIPLLANLSV-EA 171 Query: 204 N------LTQIYLQEALDFIKRQARH-HPFFLYWAVDATHAPVYASKPFLGTSQRGRYGD 256 L Y+ A D + R PFFLY+A TH P ++ + F S RG +GD Sbjct: 172 QPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGD 231 Query: 257 AVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEG 316 ++ E+D ++G ++ + DL + + T V FT+DNG + +GG +G CGK TT+EG Sbjct: 232 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SRGGCSGLLRCGKGTTYEG 290 Query: 317 GMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL-QG 375 G+REPALA+WPGH+ G V+H+L S +DL T ALAG P + +DG +L P LL G Sbjct: 291 GVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAG-APLPNVTLDGFDLSPLLLGTG 348 Query: 376 RLMDRPIFYY-------RGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVT 428 + + +F+Y RG + A G++KAHF+T ++ + C S +T Sbjct: 349 KSPRQSLFFYPSYPDEVRG--VFAVRTGKYKAHFFTQGSAHSD-TTADPAC--HASSSLT 403 Query: 429 THNLEDHTKLPLIFHLGRDPGERFPL 454 H + PL++ L +DPGE + L Sbjct: 404 AH------EPPLLYDLSKDPGENYNL 423 >6BIA-A nrPDB Length = 477 Score = 208 bits (529), Expect = 6e-54, Method: Compositional matrix adjust. Identities = 137/427 (32%), Positives = 205/427 (48%), Gaps = 28/427 (6%) Query: 27 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAAL 86 + Q PNI+L++ DD+G+ D+G G TPN+D +A G F + Y A+P C PSRAAL Sbjct: 23 SEQKPNIILIVADDLGYADVGFNGSKDIITPNIDDLAKSGTSFSDAYVAHPFCGPSRAAL 82 Query: 87 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 146 +TGR P + G N R + G+P + + +LL + Y + +GKWH+G Sbjct: 83 MTGRYPHKIG-SQFNLPTRGSNV------GVPTDAKFISKLLNENNYFTGALGKWHMGDT 135 Query: 147 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT 206 PQ HP K GFDE++G + ++ +P + + + P+ E T Sbjct: 136 PQHHPNKRGFDEYYGFLGGGHNYFPDQYQPQYKKQKAQGLKNIFEYITPLEHNGKEVKET 195 Query: 207 QIYL----QEALDFIKRQA-RHHPFFLYWAVDATHAPVYASK------PFLGTSQRGRYG 255 Q +EA++F+ + + HPFFLY A +A H P+ A P + R Y Sbjct: 196 QYITDALSREAVNFVDKAVNKKHPFFLYLAYNAPHTPLQAKDEDMAMFPNIKNKDRKTYA 255 Query: 256 DAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFE 315 V +D +GK++E L+ + DNT + F SDNG L +G +N P GK +T E Sbjct: 256 GMVYAVDRGVGKLVEALKKNNQYDNTLIVFMSDNGGKL----SKGANNFPLKAGKGSTQE 311 Query: 316 GGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQG 375 GG R P L WP HV AG+ S +DL+ T ALAG ++ +DG N+ P ++ Sbjct: 312 GGFRVPMLFHWPKHVPAGKRFSHPVSALDLYPTFAALAGAKVEENQHLDGTNMWPAFIKN 371 Query: 376 R--LMDRPIF---YYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTH 430 D PI+ + +G + A + Q KA W+ F D +VS Sbjct: 372 ENPHKDEPIYALRHRKGYSDAAIRMNQWKA-LKVNQQPWQLFNIENDISEKHDVSKSNKA 430 Query: 431 NLEDHTK 437 L D + Sbjct: 431 LLTDMVR 437 >1FSU-A nrPDB Length = 492 Score = 161 bits (407), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 149/506 (29%), Positives = 229/506 (45%), Gaps = 88/506 (17%) Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 +PP+++ LL DD+GW D+G +G R TP+LD +AA G+L N+Y+ PL +PSR+ LLT Sbjct: 2 RPPHLVFLLADDLGWNDVGFHGSRIR-TPHLDALAAGGVLLDNYYT-QPLATPSRSQLLT 59 Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIV-----GGIPDSEQLLPELLKKAGYVSKIVGKWHL 143 GR IR G +I+ +P E+LLP+LLK+AGY + +VGKWHL Sbjct: 60 GRYQIRTGLQ------------HQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHL 107 Query: 144 G-HRPQFHPLKHGFDEWFG----------SPNCHFGPYDNKARPNIPVYRDWEMVGRYYE 192 G +R + P + GFD +FG C N R + +RD E V Sbjct: 108 GMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALD-FRDGEEVA---- 162 Query: 193 EFPINLKTGEANL--TQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYAS----KP-- 244 TG N+ T I+ + A+ I P FLY A+ + H P+ KP Sbjct: 163 -------TGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYD 215 Query: 245 FLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNG 304 F+ R Y V +D+++G + L+ + +NT F++DNG ++ GG+N Sbjct: 216 FIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLA----GGNNW 271 Query: 305 PFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAID 364 P K + +EGG+R P G + +L I D T + LA + +D Sbjct: 272 PLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLD 331 Query: 365 GLNLLPTLLQGRLMDRPIFYYRGD-----------TLMA-----ATLGQHKA-----HFW 403 G ++ T+ +G R + D MA ++L ++ A H Sbjct: 332 GFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAA 391 Query: 404 TWTNSWENFRQGIDFC------PGQ-NVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSF 456 +W+ G C P Q NVS + + + TK +F + RDP ER L Sbjct: 392 IRHGNWK-LLTGYPGCGYWFPPPSQYNVSEIPSS--DPPTKTLWLFDIDRDPEERHDL-- 446 Query: 457 ASAEYQEALSRITSVVQQHQEALVPA 482 S EY ++++ S +Q + + VP Sbjct: 447 -SREYPHIVTKLLSRLQFYHKHSVPV 471 >1P49-A nrPDB Length = 562 Score = 154 bits (390), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 112/328 (34%), Positives = 160/328 (48%), Gaps = 20/328 (6%) Query: 204 NLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDD 263 NLTQ EA FI+R PF L + H +++SK F G SQ G YGDAV E+D Sbjct: 238 NLTQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDW 296 Query: 264 SIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ----GGSNGPFLCGKQTTFEGGMR 319 S+G+IL LL +L +A++T ++FTSD GA + + GGSNG + GK +EGG+R Sbjct: 297 SVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIR 356 Query: 320 EPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLM- 378 P + WP + AGQ + S MD+F T LAG P DR IDG +L+P LL+G+ Sbjct: 357 VPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP-LLEGKSQR 415 Query: 379 -DRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTH------N 431 D ++ + + A + H T+ W+ F +F P + TH + Sbjct: 416 SDHEFLFHYCNAYLNAV----RWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGS 471 Query: 432 LEDHTKLPLIFHLGRDPGERFPLSFASA-EYQEALSRITSVVQQHQEALVPAQPQLNVCN 490 H PL+F + +DP ER PL+ AS + E L + +H + L Q + N Sbjct: 472 YVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNN 531 Query: 491 WAVMNWAPPGCEKLG-KCLTPPESIPKK 517 + W C G C E K+ Sbjct: 532 FLWKPWLQLCCPSTGLSCQCDREKQDKR 559 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 58/141 (41%), Positives = 85/141 (60%), Gaps = 8/141 (5%) Query: 27 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAAL 86 A PNI+L++ DD+G GD G YG + TPN+DR+A+ G+ +A+PL +PSRAA Sbjct: 2 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLATPSRAAF 61 Query: 87 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG-- 144 +TGR P+R+G + + +T GG+P E +LLK GY + ++GKWHLG Sbjct: 62 MTGRYPVRSGMASWSRTGVFLFTASS--GGLPTDEITFAKLLKDQGYSTALIGKWHLGMS 119 Query: 145 --HRPQF--HPLKHGFDEWFG 161 + F HPL HGF+ ++G Sbjct: 120 CHSKTDFCHHPLHHGFNYFYG 140 >3ED4-A nrPDB Length = 502 Score = 148 bits (373), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 115/403 (28%), Positives = 181/403 (44%), Gaps = 69/403 (17%) Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 + PN+++++ DD+G+GDL YG +TPN+DR+A EG+ F ++Y+ PL SPSRA LLT Sbjct: 26 KQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVKFTDYYAPAPLSSPSRAGLLT 85 Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG---- 144 GR+P R G ++ P + +E + LLK GY + ++GK HL Sbjct: 86 GRMPFRTGI--------RSWIPSGKDVALGRNELTIANLLKAQGYDTAMMGKLHLNAGGD 137 Query: 145 --HRPQFHPLKHGFDEWFGSPNCHF--GPYDN-KARPNIPVYRDWEMVGRYYEEFPIN-L 198 +PQ + GFD + DN K RP RY +P L Sbjct: 138 RTDQPQAQDM--GFDYSLANTAGFVTDATLDNAKERP------------RYGMVYPTGWL 183 Query: 199 KTGE-----ANLTQIYL-QEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQR- 251 + G+ ++ Y+ E ++++ + PFFLY A H+P+ + K +L + Sbjct: 184 RNGQPTPRADKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTEVHSPLASPKKYLDMYSQY 243 Query: 252 ------------------------GRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTS 287 G Y + +D +GK+L+ ++ + DNT V FTS Sbjct: 244 MSAYQKQHPDLFYGDWADKPWRGVGEYYANISYLDAQVGKVLDKIKAMGEEDNTIVIFTS 303 Query: 288 DNG-----AALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSI 342 DNG A + G K +EGG+R PA+ + H+ G VS Sbjct: 304 DNGPVTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHLPQGMVSDTPVYG 363 Query: 343 MDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLM-DRPIFY 384 +D T + P+DR DG +L+P L Q L ++P+ + Sbjct: 364 LDWMPTLAKMMNFKLPTDRTFDGESLVPVLEQKALKREKPLIF 406 >4CXU-A nrPDB Length = 536 Score = 121 bits (303), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 123/440 (27%), Positives = 184/440 (41%), Gaps = 127/440 (28%) Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90 PN L+++ DD+G+ D+G +G TPNLD +A GL +F++A+ SP+R+ LLTG Sbjct: 5 PNFLVIVADDLGFSDIGTFG-GEIATPNLDALAIAGLRLTDFHTASA-ASPTRSMLLTGT 62 Query: 91 LPIRNGFYTTNAHARNAYTPQ-----EIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGH 145 G T A TP+ G + + LPELL++AGY + + GKWHLG Sbjct: 63 DHHIAGIGTMA----EALTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGKWHLGL 118 Query: 146 RPQFHPLKHGFDEWF----GSPNCHFG---PYDN------KARPNIPVYRDWEMVGRYYE 192 +P+ P GF+ F G+ N H+G PYD K P + V + RY + Sbjct: 119 KPEQTPHARGFERSFALLPGAAN-HYGFEPPYDESTPRILKGTPALYVEDE-----RYLD 172 Query: 193 EFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRG 252 P + +A + + L ++K + + PFF Y A H P+ A + + RG Sbjct: 173 TLPEGFYSSDA-----FGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPREIV-EKYRG 226 Query: 253 RYG---DAVRE------------------------------------------------- 260 RY +A+R+ Sbjct: 227 RYDAGPEALRQERLARLKELGLVEADVEAHPVLALTREWEALEDEERAKSARAMEVYAAM 286 Query: 261 ---IDDSIGKILELLQDLHVADNTFVFFTSDNGA--ALISA-PEQG-------------- 300 +D +IG++++ L+ DNTFV F SDNGA AL+ A P+ G Sbjct: 287 VERMDWNIGRVVDYLRRQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLDFLDRHYDNS 346 Query: 301 -------------------GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGS 341 + P K T +GG+R PAL +P G +SH + Sbjct: 347 LENIGRANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQGAISHAFAT 406 Query: 342 IMDLFTTSLALAGLTPPSDR 361 +MD+ T L LAG+ P R Sbjct: 407 VMDVTPTLLDLAGVRHPGKR 426 >2QZU-A nrPDB Length = 491 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 98/404 (24%), Positives = 168/404 (41%), Gaps = 61/404 (15%) Query: 13 LLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNF 72 L + + + G+ A PN++ ++ D +G G+ +TP+LD++A+EG+ F N Sbjct: 10 LTMPILSTGLQAQEKQPTPNLVFIMADQYRGDAIGCIGKEPVKTPHLDKLASEGINFTNA 69 Query: 73 YSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAG 132 S+ P+ SP+R L+TG PI + T N ++ A E + + + ++LK G Sbjct: 70 ISSYPVSSPARGMLMTGMYPIGSKV-TGNCNSETAPYGVE----LSQNARCWSDVLKDQG 124 Query: 133 YVSKIVGKWHLG--HRPQFHPL----------------KHGFDEW--FGSPNCHFGP-YD 171 Y +GKWHL ++P +HGFD W +G+ + H P Y Sbjct: 125 YNMGYIGKWHLDAPYKPYVDTYNNRGKVAWNEWCPPERRHGFDHWIAYGTYDYHLKPMYW 184 Query: 172 NKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWA 231 N P Y + Y I G+ + Q F + + P Y Sbjct: 185 NTTAPRDSFYYVNQWGPEYEASKAIEYINGQKDQKQ-------PFALVVSMNPPHTGYEL 237 Query: 232 VDATHAPVYA------------SKPFLGTSQRGRYGDAVRE-------IDDSIGKILELL 272 V + +Y P GT + + +R +D+++G+I+E L Sbjct: 238 VPDRYKEIYKDLDVEALCKGRPDIPAKGTEMGDYFRNNIRNYYACITGVDENVGRIIEAL 297 Query: 273 QDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTA 332 + ++ DNT V FTSD+G + A E GK +E MR P + WP + Sbjct: 298 KQNNLFDNTIVVFTSDHGICM-GAHENA--------GKDIFYEESMRIPMILSWPDQIKP 348 Query: 333 GQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGR 376 + + + DL+ T L++ G + + +L +L G+ Sbjct: 349 RKSDPLMIAFADLYPTLLSMMGFSKEIPETVQTFDLSNEVLTGK 392 >5G2V-A nrPDB Length = 534 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 80/254 (31%), Positives = 117/254 (46%), Gaps = 52/254 (20%) Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90 PNI+ ++ DD + YG +TPN+DR+A EG+ F N Y+ N L PSRA +LTG+ Sbjct: 29 PNIIFMMTDDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALSGPSRACILTGK 88 Query: 91 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFH 150 NGF T NA N +Q P+LL++AGY + ++GKWHL PQ Sbjct: 89 FSHENGF-TDNASTFNG------------DQQTFPKLLQQAGYQTAMIGKWHLISEPQ-- 133 Query: 151 PLKHGFDEW-FGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIY 209 GFD W S G Y + P+ ++E+ ++ G A T I Sbjct: 134 ----GFDHWSILSGQHEQGDYYD---PD------------FWEDGKHIVEKGYA--TDII 172 Query: 210 LQEALDFIKRQARHHPFFLYWAVDATH-----AP---------VYASKPFLGTSQRGRYG 255 +A++F++ + ++ PF + + A H AP ++ L GR G Sbjct: 173 TDKAINFLENRDKNKPFCMMYHQKAPHRNWMPAPRHLGIFNNTIFPEPANLFDDYEGR-G 231 Query: 256 DAVREIDDSIGKIL 269 A RE D SI L Sbjct: 232 KAAREQDMSIEHTL 245 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 39/119 (32%), Positives = 58/119 (48%), Gaps = 11/119 (9%) Query: 254 YGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTT 313 Y V +D++IG++L L+ + DNT + +TSD G L G +G F K+ Sbjct: 315 YLATVLAVDENIGRLLNYLEKIGELDNTIIVYTSDQGFFL-------GEHGWF--DKRFM 365 Query: 314 FEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTL 372 +E R P + +P + AG S + +D T L AG+ PSD I G +L P L Sbjct: 366 YEECQRMPLIIRYPKAIKAGSTSSAISMNVDFAPTFLDFAGVEVPSD--IQGASLKPVL 422 >4MHX-A nrPDB Length = 510 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 114/394 (28%), Positives = 155/394 (39%), Gaps = 112/394 (28%) Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 +P N LLLL DD G+ + G Y + TP+LD +A LLF N +++ SPSRA+LLT Sbjct: 21 RPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSSSPSRASLLT 79 Query: 89 GRLPIRNGFY--TTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 146 G +NG Y + H N++ D + LP LL +AG + I+GK H+G Sbjct: 80 GLPQHQNGMYGLHQDVHHFNSF----------DKVRSLPLLLSQAGVRTGIIGKKHVGPE 129 Query: 147 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT 206 + P+D Y EE L+ G N+T Sbjct: 130 TVY-------------------PFDFA----------------YTEENGSVLQVGR-NIT 153 Query: 207 QIYLQEALDFIKRQARHHPFFLYWAVDATH-----APVYAS---KPFLGTSQRGRYGD-- 256 +I L F++ Q PFFLY A H P Y + K G S GR D Sbjct: 154 RIKLL-VRKFLQTQD-DRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWT 211 Query: 257 ------------------------------AVREIDDSIGKILELLQDLHVADNTFVFFT 286 V +D +G +L+ L+D V ++T V FT Sbjct: 212 PQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFT 271 Query: 287 SDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTA-GQVSHQLGSIMDL 345 SDNG PF G+ + G EP L P H GQVS S++DL Sbjct: 272 SDNGI-------------PFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDL 318 Query: 346 FTTSLALAGLTPPS-------DRAIDGLNLLPTL 372 T L + PS + G +LLP L Sbjct: 319 TPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPAL 352 >6IOZ-A nrPDB Length = 517 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 39/113 (34%), Positives = 60/113 (53%), Gaps = 19/113 (16%) Query: 32 NILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGRL 91 N+LL+++DD+ LG YG+ +PN+D++A+ LLF N ++ + +PSR + LTGR Sbjct: 5 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVAAPSRVSFLTGRR 63 Query: 92 PIRNGFYTTNA----HARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGK 140 P Y N+ HA N T +P+ K+ GYV+ VGK Sbjct: 64 PDTTRLYDFNSYWRVHAGNFST--------------IPQYFKENGYVTMSVGK 102 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 10/123 (8%) Query: 251 RGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGK 310 R Y +V +D +G++L L DL +A++T + FTSD+G AL G +G + K Sbjct: 264 RQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL-------GEHGEW--AK 314 Query: 311 QTTFEGGMREPALAWWPGHVTA-GQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL 369 + F+ P + + PG + + +L +D F ++ L S ++ ++L Sbjct: 315 YSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLF 374 Query: 370 PTL 372 PTL Sbjct: 375 PTL 377 >4UPL-A nrPDB Length = 569 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 30/87 (34%), Positives = 45/87 (51%), Gaps = 11/87 (12%) Query: 32 NILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR- 90 NIL ++ D + W L YG + TP++DR+AA+G+ F Y +P+C SR + TGR Sbjct: 19 NILFIMFDQLRWDYLSCYGHKTLNTPHIDRLAAKGVRFDRAYIQSPICGSSRMSTYTGRY 78 Query: 91 ----------LPIRNGFYTTNAHARNA 107 +P++ G T H R A Sbjct: 79 VHSHGASWNGIPLKVGEMTMGDHLRAA 105 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/139 (27%), Positives = 61/139 (43%), Gaps = 18/139 (12%) Query: 254 YGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTT 313 Y +++ DD +G++ + L+D +T + TSD+G L G G++T Sbjct: 309 YMGLIKQADDQMGRLFKWLEDTGRMQDTMIVLTSDHGDFL----------GDHWMGEKTF 358 Query: 314 F-EGGMREPALAWWP---GHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL 369 F + R P + + P T G V L +DL T + AG P+ ++G +L+ Sbjct: 359 FHDASTRVPLIIYDPRPEADATRGSVCDALVESIDLAPTFVEAAG-GKPAMHILEGESLI 417 Query: 370 PTLLQGR---LMDRPIFYY 385 P L R L D I Y Sbjct: 418 PILHGARDHTLRDHVICEY 436 >4UG4-A nrPDB Length = 515 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 42/129 (32%), Positives = 61/129 (47%), Gaps = 19/129 (14%) Query: 31 PNILLLLMDDMGWGDLGVYGEPS-RETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTG 89 PNIL++++D + G L G PNL +A F N Y+++PLC+P+RA+ + G Sbjct: 9 PNILIIMVDQLN-GKLFPDGPADFLHAPNLKALAKRSARFHNNYTSSPLCAPARASFMAG 67 Query: 90 RLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQF 149 +LP R Y A E IP L++AGY + + GK H Q Sbjct: 68 QLPSRTRVYDNAA---------EYQSSIP----TYAHHLRRAGYYTALSGKMHFVGPDQL 114 Query: 150 HPLKHGFDE 158 HGF+E Sbjct: 115 ----HGFEE 119 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 57/123 (46%), Gaps = 12/123 (9%) Query: 251 RGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGK 310 R Y + +D+ +G++++ L + D+T + F SD+G L G G L K Sbjct: 262 RRAYFANISYLDEKVGELIDTLTRTRMLDDTLILFCSDHGDML-------GERG--LWFK 312 Query: 311 QTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRA-IDGLNLL 369 FEG R P + PG ++ S +D+ T LAG++ R DG++L+ Sbjct: 313 MNFFEGSARVPLMIAGPGIAPGLHLTPT--SNLDVTPTLADLAGISLEEVRPWTDGVSLV 370 Query: 370 PTL 372 P + Sbjct: 371 PMV 373 >5G2T-A nrPDB Length = 489 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 33/114 (28%), Positives = 55/114 (48%), Gaps = 8/114 (7%) Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 + PN L++ D + +G YG+ T +D +A+ G++F N Y PL PSRAAL + Sbjct: 22 EKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPLSQPSRAALWS 81 Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWH 142 G +P + + ++ N P+ + L L ++GY + GK H Sbjct: 82 GMMPHQTNVRSNSSEPVNTRLPENV--------PTLGSLFSESGYEAVHFGKTH 127 Score = 35.0 bits (79), Expect = 0.076, Method: Compositional matrix adjust. Identities = 51/207 (24%), Positives = 83/207 (40%), Gaps = 47/207 (22%) Query: 258 VREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGG 317 + + + +L+ L NT V +D+G + S + K +F Sbjct: 261 TKMVSKQVDSVLKALYSTPAGRNTIVVIMADHGDGMASH---------RMVTKHISFYDE 311 Query: 318 MRE-PALAWWPGHVTAGQ-VSHQLGS-IMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQ 374 M P + PG + V H L +DL T LAG+ P+++A G++L PTL Sbjct: 312 MTNVPFIFAGPGIKQQKKPVDHLLTQPTLDLLPTLCDLAGIAVPAEKA--GISLAPTL-- 367 Query: 375 GRLMDRPIFYYRGDTLMAATLGQHKAHFWT---WTNSWENFRQGIDFCPGQNVSG---VT 428 RG+ Q K+H + W + +E PG+ V G Sbjct: 368 -----------RGEK-------QKKSHPYVVSEWHSEYEYVT-----TPGRMVRGPRYKY 404 Query: 429 THNLEDHTKLPLIFHLGRDPGERFPLS 455 TH LE + + ++ + +DPGER L+ Sbjct: 405 THYLEGNGE--ELYDMKKDPGERKNLA 429 >2W8S-A nrPDB Length = 543 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 47/141 (33%), Positives = 64/141 (45%), Gaps = 15/141 (10%) Query: 251 RGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGK 310 R Y + EIDD +G++ L + D+T + FTSD+G EQ G + L GK Sbjct: 316 RATYCGLITEIDDCLGRVFAYLDETGQWDDTLIIFTSDHG-------EQLGDH--HLLGK 366 Query: 311 QTTFEGGMREPALAWWPGHVT-AGQVSHQLGSIMDLFTTSLA-LAGLTPPSDRAIDGLNL 368 R P + G AGQ+ +D+ T L L G TP RA DG +L Sbjct: 367 IGYNAESFRIPLVIKDAGQNRHAGQIEEGFSESIDVMPTILEWLGGETP---RACDGRSL 423 Query: 369 LPTLLQGRLMD-RPIFYYRGD 388 LP L +G+ D R +Y D Sbjct: 424 LPFLAEGKPSDWRTELHYEFD 444 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 20/39 (51%), Positives = 25/39 (64%) Query: 51 EPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTG 89 EP +TPNLDR+ EGL F N + P+RA+LLTG Sbjct: 58 EPFLKTPNLDRLCREGLTFRNHVTTCVPGGPARASLLTG 96 >4UPI-A nrPDB Length = 576 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 39/127 (30%), Positives = 58/127 (45%), Gaps = 19/127 (14%) Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 Q NIL ++ D + + L YG TPN+D++A G+ F N Y + PSR + T Sbjct: 27 QNRNILWIMCDQLRFDYLSCYGHERLNTPNIDKLAKRGVRFTNAYVQATVAGPSRMSAYT 86 Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIP--DSEQLLPELLKKAGYVSKIVGKWHLGHR 146 GR +R+ T N GIP E L + L+ G + ++GK H+ R Sbjct: 87 GRY-VRSHGSTQN--------------GIPLRVGEPTLGDHLRDVGMRNVLIGKTHM--R 129 Query: 147 PQFHPLK 153 P +K Sbjct: 130 PDLDGMK 136 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/123 (29%), Positives = 60/123 (48%), Gaps = 15/123 (12%) Query: 254 YGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTT 313 Y +++IDD +G++ +Q+ + +NT + FT+D+G L G G++ Sbjct: 318 YMGLIKQIDDQLGQLFAFMQERGLDENTMIVFTADHGDYL----------GDHWMGEKYL 367 Query: 314 F-EGGMREPALAWWP---GHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL 369 F E + P + + P T G VS L ++DL T + AG PP ++G +LL Sbjct: 368 FYEAAAKVPLIIYDPSDKADATRGTVSDALVEMIDLAPTFVDYAGGVPPM-HILEGKSLL 426 Query: 370 PTL 372 P L Sbjct: 427 PLL 429 >4UPH-A nrPDB Length = 547 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 12/129 (9%) Query: 248 TSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFL 307 ++ R Y + E+D +G+I + L+++ D+T + FTSD+ E G + ++ Sbjct: 317 SAIRAIYYGMIAEVDTQLGRIWQALKNVGAWDDTLIIFTSDHA-------EMMGDH--WM 367 Query: 308 CGKQTTFEGGMREPALAWWPGHV-TAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGL 366 GK F+G P + PGH AG+ + S D+F T GL P D +DG Sbjct: 368 LGKGGFFDGSYHVPLVIRDPGHPGGAGRQVERFTSAADIFPTLCDRLGLVP--DNHLDGG 425 Query: 367 NLLPTLLQG 375 L+P L G Sbjct: 426 TLVPFLEGG 434 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 23/59 (38%), Positives = 33/59 (55%) Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTG 89 PN+LL+ D L G S +TPN+D +A +G+LF ++ SP+RA L TG Sbjct: 45 PNVLLISADQWRGDCLSAVGHASVKTPNVDALAQDGVLFTRHFAGTAPASPARATLYTG 103 >2VQR-A nrPDB Length = 543 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 45/141 (31%), Positives = 64/141 (45%), Gaps = 15/141 (10%) Query: 251 RGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGK 310 R Y + E+DD +G++ L + D+T + FTSD+G EQ G + L GK Sbjct: 316 RATYCGLITEVDDCLGRVFSYLDETGQWDDTLIIFTSDHG-------EQLGDH--HLLGK 366 Query: 311 QTTFEGGMREPALAWWPG-HVTAGQVSHQLGSIMDLFTTSLA-LAGLTPPSDRAIDGLNL 368 + R P + G + AG + +D+ T L L G P A DGL+L Sbjct: 367 IGYNDPSFRIPLVIKDAGENARAGAIESGFTESIDVMPTILDWLGGKIP---HACDGLSL 423 Query: 369 LPTLLQGRLMD-RPIFYYRGD 388 LP L +GR D R +Y D Sbjct: 424 LPFLSEGRPQDWRTELHYEYD 444 Score = 36.6 bits (83), Expect = 0.029, Method: Compositional matrix adjust. Identities = 17/35 (48%), Positives = 23/35 (65%) Query: 55 ETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTG 89 +TPNLDR+ EG+ F N + P+RA+LLTG Sbjct: 62 KTPNLDRLCREGVTFRNHVTTCVPAGPARASLLTG 96 >4UPK-A nrPDB Length = 538 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 12/122 (9%) Query: 251 RGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGK 310 R Y E+D IG+++ L++ D+T + T+D+G L G + GK Sbjct: 310 RAVYLGLATEVDTHIGRVIAHLKETGQYDDTLIVVTADHGEML------GDRHS---WGK 360 Query: 311 QTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLP 370 T ++ P + PG G V +DL T L G P+ A+DG +L P Sbjct: 361 MTVYDAAYHTPLIIRAPG-CKPGHVVEAPTESIDLMPTILDWVGQEIPN--AVDGRSLRP 417 Query: 371 TL 372 L Sbjct: 418 FL 419 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 54/121 (44%), Gaps = 21/121 (17%) Query: 32 NILLLLMD----DMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALL 87 N+L +++D D WG L + E P+L +A + + F YS C PSRA++L Sbjct: 35 NVLFIIIDQLRADCLWGALADH----VELPHLRALAQDAVSFRRHYSVTNPCGPSRASIL 90 Query: 88 TGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRP 147 TG+ Y N + TP D+ + E ++KAGY+ + G P Sbjct: 91 TGQ-------YAMNHRSVRNGTPLRH-----DTPNIATE-MRKAGYLPLLFGYTDTSQDP 137 Query: 148 Q 148 + Sbjct: 138 R 138 >4UOP-A nrPDB Length = 442 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 74/359 (20%), Positives = 136/359 (37%), Gaps = 62/359 (17%) Query: 26 GAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRA- 84 GA + N++++ ++ V TP LD + E + F+ + + A Sbjct: 53 GAAKGKNLIIVQLESFQRNLTNVKINGQSITPTLDGLQNETMYSNQFFQTVSKSNTADAE 112 Query: 85 -ALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKI--VGKW 141 ++ T P +G+YT + P +P LL K Y + Sbjct: 113 WSVYTSTFP--SGYYTNTQTYGDRVIPS------------MPRLLGKNDYKTATFHTNDA 158 Query: 142 HLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVG-------RYYEEF 194 +R +F+P GFD++ YD K + D +++G Y + F Sbjct: 159 SFYNRDEFYPAV-GFDKF----------YDRK------FFGDEDVIGFSPSDEVLYNKAF 201 Query: 195 PINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRY 254 PI L+ N + Y Q + + H PF + P L ++ G Y Sbjct: 202 PI-LEEQYKNNQKFYAQ-----LISVSSHMPFDIPKDKQEIDLP-----SDLKDTELGNY 250 Query: 255 GDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTF 314 +AV D +G+ ++ L+D + D++ V F D+ I +Q + T Sbjct: 251 FEAVHYADKQLGEFIQKLKDSGIWDDSVVVFYGDHH---IIKTDQLPEEQKKYVNRSTQL 307 Query: 315 EG----GMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL 369 + R P +PG G++ + +G +D+ T + L G+ D+ + G ++L Sbjct: 308 KAEPADDYRIPFFLHYPGMENPGEIKN-VGGEIDIMPTVMNLLGI-KTGDQIMFGTDIL 364 >5I5H-A nrPDB Length = 586 Score = 37.0 bits (84), Expect = 0.024, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 50/121 (41%), Gaps = 20/121 (16%) Query: 253 RYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQT 312 +Y A +DD I ++L L+D DNT V T+ G L E Sbjct: 415 KYSRAAGNVDDQINRVLNALRDSGKLDNTVVIITAGRGIPLSEEEE-------------- 460 Query: 313 TFE---GGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLA-LAGLTPPSDRAIDGLNL 368 TF+ G ++ P + WPG T Q + L DL TT + L ++ P+ G +L Sbjct: 461 TFDWSHGHLQVPLVIHWPG--TPAQRINALTDHTDLMTTLMQRLLHVSTPASEYSQGQDL 518 Query: 369 L 369 Sbjct: 519 F 519 >5I5F-A nrPDB Length = 586 Score = 35.4 bits (80), Expect = 0.064, Method: Compositional matrix adjust. Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 14/118 (11%) Query: 253 RYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQT 312 RY A ++D I ++L L++ DNT V T+ G L PE+ + Sbjct: 415 RYASAASDVDAQINRVLNALREAGKFDNTVVIITAGRGIPL--TPEENRFDWS------- 465 Query: 313 TFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLA-LAGLTPPSDRAIDGLNLL 369 +G ++ P + WPG T Q + L D+ TT + L ++ P++ G ++ Sbjct: 466 --QGHLQVPLVIHWPG--TPAQRINVLTDHTDVMTTLMQRLLHVSTPANEYSQGQDIF 519 >5XWI-A nrPDB Length = 567 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 7/81 (8%) Query: 25 SGAPQPPNILLLLMDDMGWGDLGVYGEPSRE-TPNLDRMAAEGLLFPNFY---SANPLCS 80 S A PP +++ + D DL + E + T L R+ +EG +FP Y +A C Sbjct: 34 SIAATPPKLIVAISVDQFSADL--FSEYRQYYTGGLKRLTSEGAVFPRGYQSHAATETC- 90 Query: 81 PSRAALLTGRLPIRNGFYTTN 101 P + +LTG P R G N Sbjct: 91 PGHSTILTGSRPSRTGIIANN 111 >3C0Q-A nrPDB Length = 301 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 19/48 (39%), Gaps = 4/48 (8%) Query: 144 GHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYR----DWEMV 187 G P L+ F W G P H D K RP +R DWE + Sbjct: 230 GRLPLEEALRLAFPTWRGRPKVHLASQDPKKRPGAHAFRVTREDWERL 277 >5OLB-A nrPDB Length = 844 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 15/61 (24%), Positives = 32/61 (52%), Gaps = 4/61 (6%) Query: 240 YASKPFLGTSQRGRYG----DAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALIS 295 Y+ +P + G +G + +REID ++G++++ L+ L + V F D+G ++ Sbjct: 275 YSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVT 334 Query: 296 A 296 Sbjct: 335 C 335 >4LZI-A nrPDB Length = 282 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 19/57 (33%), Positives = 29/57 (50%), Gaps = 9/57 (15%) Query: 363 IDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAH-FWTWTNSWENFRQGIDF 418 ++ LN+ L+ G L YY TL+A G+ K + W WENF++ I+F Sbjct: 134 VENLNVKEQLVAGML------YYI--TLVAIDAGKKKIYEAKIWVKEWENFKKVIEF 182 >4LR2-A nrPDB Length = 401 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 26/49 (53%) Query: 247 GTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALIS 295 G + +++IDD IG +++ L+ L + +N V TSD+G S Sbjct: 181 GPEDKENMSRVLKKIDDLIGDLVQRLKMLGLWENLNVIITSDHGMTQCS 229 >5UDY-A nrPDB Length = 422 Score = 28.5 bits (62), Expect = 7.2, Method: Compositional matrix adjust. Identities = 11/40 (27%), Positives = 22/40 (55%) Query: 256 DAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALIS 295 + VR++D ++G + E + H+ D + TSD+G + Sbjct: 203 EMVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVD 242 Score = 28.5 bits (62), Expect = 7.3, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 17/85 (20%) Query: 33 ILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGL----LFPNFYSANPLCSPSRAALLT 88 +LL+ D W + +TPNLD MA +G+ + P F + + SP L+T Sbjct: 22 LLLVSFDGFRWN-----YDQDVDTPNLDAMARDGVKARYMTPAFVT---MTSPCHFTLVT 73 Query: 89 GRL-----PIRNGFYTTNAHARNAY 108 G+ + N +Y T + + Y Sbjct: 74 GKYIENHGVVHNMYYNTTSKVKLPY 98 >3D1Q-A nrPDB Length = 340 Score = 28.5 bits (62), Expect = 7.5, Method: Compositional matrix adjust. Identities = 13/35 (37%), Positives = 21/35 (60%) Query: 180 VYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEAL 214 +YR E+ G YY EFPI K ++ T+ Y ++ + Sbjct: 274 LYRQHEIGGFYYGEFPIKTKDKDSWKTKYYREKIV 308 >5VEN-A nrPDB Length = 416 Score = 28.1 bits (61), Expect = 9.4, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 9/70 (12%) Query: 227 FLYWAV-DATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFF 285 FLYW D T V P +G+ + ++D +G ++++L+ + +N + Sbjct: 170 FLYWEEPDDTGHDVGPDSPLMGS--------VISDVDHKLGYLIKMLKRAKLWNNVNLIV 221 Query: 286 TSDNGAALIS 295 TSD+G S Sbjct: 222 TSDHGMTQCS 231 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4FDJ-A nrPDB 696 0.0 6BIA-A nrPDB 426 e-119 1FSU-A nrPDB 410 e-115 1E2S-P nrPDB 400 e-112 1P49-A nrPDB 388 e-108 2QZU-A nrPDB 344 4e-95 3ED4-A nrPDB 339 2e-93 4CXU-A nrPDB 279 2e-75 4UPI-A nrPDB 256 2e-68 4UPL-A nrPDB 249 2e-66 4UG4-A nrPDB 235 2e-62 4MHX-A nrPDB 222 5e-58 5G2V-A nrPDB 220 1e-57 4UPH-A nrPDB 207 1e-53 2VQR-A nrPDB 207 1e-53 6IOZ-A nrPDB 202 3e-52 2W8S-A nrPDB 200 2e-51 5G2T-A nrPDB 190 1e-48 Sequences not found previously or not previously below threshold: 4UPK-A nrPDB 151 9e-37 3LXQ-A nrPDB 98 1e-20 4UOP-A nrPDB 87 2e-17 2W8D-A nrPDB 71 9e-13 5I5H-A nrPDB 71 2e-12 5I5F-A nrPDB 68 1e-11 2W5S-A nrPDB 66 4e-11 4UOO-A nrPDB 63 3e-10 5UDY-A nrPDB 59 6e-09 5KGM-A nrPDB 49 4e-06 5XWI-A nrPDB 47 2e-05 4B56-A nrPDB 46 6e-05 4LR2-A nrPDB 44 2e-04 6C01-A nrPDB 44 2e-04 6G4G-A nrPDB 43 2e-04 4LR8-A nrPDB 43 2e-04 1O99-A nrPDB 43 5e-04 5MX9-A nrPDB 42 7e-04 4QAX-A nrPDB 41 0.001 5GZ5-A nrPDB 41 0.001 5VEN-A nrPDB 39 0.004 2W5W-A nrPDB 39 0.005 5YLE-A nrPDB 39 0.006 5VPU-A nrPDB 37 0.019 6A83-A nrPDB 35 0.067 5VEM-A nrPDB 35 0.070 2X6Q-A nrPDB 35 0.077 5OLB-A nrPDB 34 0.13 5MHP-A nrPDB 34 0.17 6EPD-M nrPDB 33 0.26 5VHO-F nrPDB 33 0.26 5VFP-F nrPDB 33 0.26 5YKC-A nrPDB 31 1.4 1CBY-A nrPDB 31 1.7 6EHL-A nrPDB 31 1.8 6REQ-B nrPDB 31 1.8 5Z6H-A nrPDB 31 2.0 3PLS-A nrPDB 30 2.3 3IU6-A nrPDB 30 2.8 1UPS-A nrPDB 30 3.1 3KW7-A nrPDB 29 3.9 1PUJ-A nrPDB 29 4.0 1NTF-A nrPDB 29 4.5 5NQ8-A nrPDB 28 8.0 >4FDJ-A nrPDB Length = 502 Score = 696 bits (1796), Expect = 0.0, Method: Composition-based stats. Identities = 495/496 (99%), Positives = 495/496 (99%) Query: 27 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAAL 86 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPL SPSRAAL Sbjct: 1 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAAL 60 Query: 87 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 146 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR Sbjct: 61 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 120 Query: 147 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT 206 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT Sbjct: 121 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT 180 Query: 207 QIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIG 266 QIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIG Sbjct: 181 QIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIG 240 Query: 267 KILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWW 326 KILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWW Sbjct: 241 KILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWW 300 Query: 327 PGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYR 386 PGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYR Sbjct: 301 PGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYR 360 Query: 387 GDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGR 446 GDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGR Sbjct: 361 GDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGR 420 Query: 447 DPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGK 506 DPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGK Sbjct: 421 DPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGK 480 Query: 507 CLTPPESIPKKCLWSH 522 CLTPPESIPKKCLWSH Sbjct: 481 CLTPPESIPKKCLWSH 496 >6BIA-A nrPDB Length = 477 Score = 426 bits (1095), Expect = e-119, Method: Composition-based stats. Identities = 137/427 (32%), Positives = 204/427 (47%), Gaps = 28/427 (6%) Query: 27 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAAL 86 + Q PNI+L++ DD+G+ D+G G TPN+D +A G F + Y A+P C PSRAAL Sbjct: 23 SEQKPNIILIVADDLGYADVGFNGSKDIITPNIDDLAKSGTSFSDAYVAHPFCGPSRAAL 82 Query: 87 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 146 +TGR P + G N R + G+P + + +LL + Y + +GKWH+G Sbjct: 83 MTGRYPHKIG-SQFNLPTRGSNV------GVPTDAKFISKLLNENNYFTGALGKWHMGDT 135 Query: 147 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT 206 PQ HP K GFDE++G + ++ +P + + + P+ E T Sbjct: 136 PQHHPNKRGFDEYYGFLGGGHNYFPDQYQPQYKKQKAQGLKNIFEYITPLEHNGKEVKET 195 Query: 207 QIYLQ----EALDFIKRQ-ARHHPFFLYWAVDATHAPVYASK------PFLGTSQRGRYG 255 Q EA++F+ + + HPFFLY A +A H P+ A P + R Y Sbjct: 196 QYITDALSREAVNFVDKAVNKKHPFFLYLAYNAPHTPLQAKDEDMAMFPNIKNKDRKTYA 255 Query: 256 DAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFE 315 V +D +GK++E L+ + DNT + F SDNG L +G +N P GK +T E Sbjct: 256 GMVYAVDRGVGKLVEALKKNNQYDNTLIVFMSDNGGKL----SKGANNFPLKAGKGSTQE 311 Query: 316 GGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQG 375 GG R P L WP HV AG+ S +DL+ T ALAG ++ +DG N+ P ++ Sbjct: 312 GGFRVPMLFHWPKHVPAGKRFSHPVSALDLYPTFAALAGAKVEENQHLDGTNMWPAFIKN 371 Query: 376 R--LMDRPIF---YYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTH 430 D PI+ + +G + A + Q KA W+ F D +VS Sbjct: 372 ENPHKDEPIYALRHRKGYSDAAIRMNQWKA-LKVNQQPWQLFNIENDISEKHDVSKSNKA 430 Query: 431 NLEDHTK 437 L D + Sbjct: 431 LLTDMVR 437 >1FSU-A nrPDB Length = 492 Score = 410 bits (1054), Expect = e-115, Method: Composition-based stats. Identities = 144/523 (27%), Positives = 224/523 (42%), Gaps = 84/523 (16%) Query: 28 PQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALL 87 +PP+++ LL DD+GW D+G +G TP+LD +AA G+L N+Y+ PL +PSR+ LL Sbjct: 1 SRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQ-PLATPSRSQLL 58 Query: 88 TGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG-HR 146 TGR IR G +P E+LLP+LLK+AGY + +VGKWHLG +R Sbjct: 59 TGRYQIRTGLQHQ-------IIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYR 111 Query: 147 PQFHPLKHGFDEWFG----------SPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPI 196 + P + GFD +FG C N R + Sbjct: 112 KECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDG------------E 159 Query: 197 NLKTGEANL--TQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASK------PFLGT 248 + TG N+ T I+ + A+ I P FLY A+ + H P+ + F+ Sbjct: 160 EVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQD 219 Query: 249 SQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLC 308 R Y V +D+++G + L+ + +NT F++DNG ++ GG+N P Sbjct: 220 KNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLA----GGNNWPLRG 275 Query: 309 GKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNL 368 K + +EGG+R P G + +L I D T + LA + +DG ++ Sbjct: 276 RKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDV 335 Query: 369 LPTLLQGRLMDRPIFYYRGD-----------TLMA-----ATLGQHKA-----HFWTWTN 407 T+ +G R + D MA ++L ++ A H Sbjct: 336 WKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHG 395 Query: 408 SWENFRQGIDFC------PGQ-NVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAE 460 +W+ G C P Q NVS + + + TK +F + RDP ER L S E Sbjct: 396 NWK-LLTGYPGCGYWFPPPSQYNVSEIPSS--DPPTKTLWLFDIDRDPEERHDL---SRE 449 Query: 461 YQEALSRITSVVQQHQEALVPA--QPQLNVCN----WAVMNWA 497 Y ++++ S +Q + + VP Q C+ W Sbjct: 450 YPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM 492 >1E2S-P nrPDB Length = 489 Score = 400 bits (1028), Expect = e-112, Method: Composition-based stats. Identities = 168/443 (37%), Positives = 235/443 (53%), Gaps = 37/443 (8%) Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 +PPNI+L+ DD+G+GDLG YG PS TPNLD++AA GL F +FY L +PSRAALLT Sbjct: 1 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLATPSRAALLT 60 Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148 GRLP+R G Y GG+P E + E+L GY++ + GKWHLG P+ Sbjct: 61 GRLPVRMGMYP-------GVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPE 113 Query: 149 --FHPLKHGFDEWFGSPNCH-FGPYDNKA--RPNIPVYRDWEMVGRYYEEFPINLKTGEA 203 F P GF + G P H GP N P P + G NL Sbjct: 114 GAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQ-GLVPIPLLANLSVEAQ 172 Query: 204 -----NLTQIYLQEALDFIKRQAR-HHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDA 257 L Y+ A D + R PFFLY+A TH P ++ + F S RG +GD+ Sbjct: 173 PPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDS 232 Query: 258 VREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGG 317 + E+D ++G ++ + DL + + T V FT+DNG + +GG +G CGK TT+EGG Sbjct: 233 LMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SRGGCSGLLRCGKGTTYEGG 291 Query: 318 MREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQ-GR 376 +REPALA+WPGH+ G V+H+L S +DL T ALAG P + +DG +L P LL G+ Sbjct: 292 VREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGTGK 349 Query: 377 LMDRPIFYY-----RGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHN 431 + +F+Y + A G++KAHF+T ++ + C S +T H Sbjct: 350 SPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSD-TTADPAC--HASSSLTAH- 405 Query: 432 LEDHTKLPLIFHLGRDPGERFPL 454 + PL++ L +DPGE + L Sbjct: 406 -----EPPLLYDLSKDPGENYNL 423 >1P49-A nrPDB Length = 562 Score = 388 bits (996), Expect = e-108, Method: Composition-based stats. Identities = 110/330 (33%), Positives = 156/330 (47%), Gaps = 18/330 (5%) Query: 201 GEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVRE 260 NLTQ EA FI+R PF L + H +++SK F G SQ G YGDAV E Sbjct: 235 SYDNLTQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEE 293 Query: 261 IDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG----GSNGPFLCGKQTTFEG 316 +D S+G+IL LL +L +A++T ++FTSD GA + +G GSNG + GK +EG Sbjct: 294 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 353 Query: 317 GMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGR 376 G+R P + WP + AGQ + S MD+F T LAG P DR IDG +L+P L Sbjct: 354 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKS 413 Query: 377 LM-DRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTH----- 430 D ++ + + A + H T+ W+ F +F P + TH Sbjct: 414 QRSDHEFLFHYCNAYLNAV----RWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCF 469 Query: 431 -NLEDHTKLPLIFHLGRDPGERFPLSFASA-EYQEALSRITSVVQQHQEALVPAQPQLNV 488 + H PL+F + +DP ER PL+ AS + E L + +H + L Q + Sbjct: 470 GSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSW 529 Query: 489 CNWAVMNWAPPGCEKLG-KCLTPPESIPKK 517 N+ W C G C E K+ Sbjct: 530 NNFLWKPWLQLCCPSTGLSCQCDREKQDKR 559 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 58/150 (38%), Positives = 86/150 (57%), Gaps = 8/150 (5%) Query: 27 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAAL 86 A PNI+L++ DD+G GD G YG + TPN+DR+A+ G+ +A+PL +PSRAA Sbjct: 2 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLATPSRAAF 61 Query: 87 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG-- 144 +TGR P+R+G + + +T GG+P E +LLK GY + ++GKWHLG Sbjct: 62 MTGRYPVRSGMASWSRTGVFLFTASS--GGLPTDEITFAKLLKDQGYSTALIGKWHLGMS 119 Query: 145 --HRPQF--HPLKHGFDEWFGSPNCHFGPY 170 + F HPL HGF+ ++G + Sbjct: 120 CHSKTDFCHHPLHHGFNYFYGISLTNLRDC 149 >2QZU-A nrPDB Length = 491 Score = 344 bits (883), Expect = 4e-95, Method: Composition-based stats. Identities = 105/501 (20%), Positives = 189/501 (37%), Gaps = 87/501 (17%) Query: 13 LLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNF 72 L + + + G+ A PN++ ++ D +G G+ +TP+LD++A+EG+ F N Sbjct: 10 LTMPILSTGLQAQEKQPTPNLVFIMADQYRGDAIGCIGKEPVKTPHLDKLASEGINFTNA 69 Query: 73 YSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAG 132 S+ P+ SP+R L+TG PI + T N ++ A E + + + ++LK G Sbjct: 70 ISSYPVSSPARGMLMTGMYPIGSKV-TGNCNSETAPYGVE----LSQNARCWSDVLKDQG 124 Query: 133 YVSKIVGKWHLG--HRPQFHPL----------------KHGFDEW--FGSPNCHFGP-YD 171 Y +GKWHL ++P +HGFD W +G+ + H P Y Sbjct: 125 YNMGYIGKWHLDAPYKPYVDTYNNRGKVAWNEWCPPERRHGFDHWIAYGTYDYHLKPMYW 184 Query: 172 NKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWA 231 N P Y + Y I G+ + Q F + + P Y Sbjct: 185 NTTAPRDSFYYVNQWGPEYEASKAIEYINGQKDQKQ-------PFALVVSMNPPHTGYEL 237 Query: 232 VDATHAPVY------------ASKPFLGTSQRGRYGDAVRE-------IDDSIGKILELL 272 V + +Y P GT + + +R +D+++G+I+E L Sbjct: 238 VPDRYKEIYKDLDVEALCKGRPDIPAKGTEMGDYFRNNIRNYYACITGVDENVGRIIEAL 297 Query: 273 QDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTA 332 + ++ DNT V FTSD+G + + GK +E MR P + WP + Sbjct: 298 KQNNLFDNTIVVFTSDHGICMGAHEN---------AGKDIFYEESMRIPMILSWPDQIKP 348 Query: 333 GQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMD---RPIFYYRGDT 389 + + + DL+ T L++ G + + +L +L G+ +P ++ + D Sbjct: 349 RKSDPLMIAFADLYPTLLSMMGFSKEIPETVQTFDLSNEVLTGKNKKDLVQPYYFVKFDN 408 Query: 390 LMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPG 449 + R + H + ++F DP Sbjct: 409 HA---------------TGYRGLRT--------DRYTYAVHATDGKIDNVILFDRTNDPH 445 Query: 450 ERFPLSFASAEYQEALSRITS 470 E ++ + +R Sbjct: 446 EMNNIASQQLKLTHTFNRQLK 466 >3ED4-A nrPDB Length = 502 Score = 339 bits (869), Expect = 2e-93, Method: Composition-based stats. Identities = 122/490 (24%), Positives = 194/490 (39%), Gaps = 73/490 (14%) Query: 28 PQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALL 87 + PN+++++ DD+G+GDL YG +TPN+DR+A EG+ F ++Y+ PL SPSRA LL Sbjct: 25 AKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVKFTDYYAPAPLSSPSRAGLL 84 Query: 88 TGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG--- 144 TGR+P R G + + P + +E + LLK GY + ++GK HL Sbjct: 85 TGRMPFRTGIRS--------WIPSGKDVALGRNELTIANLLKAQGYDTAMMGKLHLNAGG 136 Query: 145 ---HRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPIN-LKT 200 +PQ + GFD + + + RY +P L+ Sbjct: 137 DRTDQPQAQDM--GFDYSLANTAGFVTDA---------TLDNAKERPRYGMVYPTGWLRN 185 Query: 201 GE-----ANLTQIYL-QEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQR--- 251 G+ ++ Y+ E ++++ + PFFLY A H+P+ + K +L + Sbjct: 186 GQPTPRADKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTEVHSPLASPKKYLDMYSQYMS 245 Query: 252 ----------------------GRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDN 289 G Y + +D +GK+L+ ++ + DNT V FTSDN Sbjct: 246 AYQKQHPDLFYGDWADKPWRGVGEYYANISYLDAQVGKVLDKIKAMGEEDNTIVIFTSDN 305 Query: 290 G-----AALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMD 344 G A + G K +EGG+R PA+ + H+ G VS +D Sbjct: 306 GPVTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHLPQGMVSDTPVYGLD 365 Query: 345 LFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLM--------AATLG 396 T + P+DR DG +L+P L Q L + D A G Sbjct: 366 WMPTLAKMMNFKLPTDRTFDGESLVPVLEQKALKREKPLIFGIDMPFQDDPTDEWAIRDG 425 Query: 397 QHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSF 456 K + D N+ G + L + D L Sbjct: 426 DWKMIIDRNNKPKYLYNLKSDRYETLNLIGKKPDIEKQMYGKFLKYKTDID---NDSLMK 482 Query: 457 ASAEYQEALS 466 A + EA++ Sbjct: 483 ARGDKPEAVT 492 >4CXU-A nrPDB Length = 536 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 126/538 (23%), Positives = 189/538 (35%), Gaps = 146/538 (27%) Query: 28 PQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALL 87 + PN L+++ DD+G+ D+G +G TPNLD +A GL +F++A+ SP+R+ LL Sbjct: 2 SKRPNFLVIVADDLGFSDIGTFGGE-IATPNLDALAIAGLRLTDFHTASA-ASPTRSMLL 59 Query: 88 TGRLPIRNGFYTTN-AHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 146 TG G T A G + + LPELL++AGY + + GKWHLG + Sbjct: 60 TGTDHHIAGIGTMAEALTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGKWHLGLK 119 Query: 147 PQFHPLKHGFDEWFG------SPNCHFGPYDNKAR------PNIPVYRDWEMVGRYYEEF 194 P+ P GF+ F + PYD P + V + RY + Sbjct: 120 PEQTPHARGFERSFALLPGAANHYGFEPPYDESTPRILKGTPALYVEDE-----RYLDTL 174 Query: 195 PINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKP---------- 244 P + +A + + L ++K + + PFF Y A H P+ A + Sbjct: 175 PEGFYSSDA-----FGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPREIVEKYRGRYD 229 Query: 245 -------------------------------------FLGTSQRGR-------YGDAVRE 260 L +R + Y V Sbjct: 230 AGPEALRQERLARLKELGLVEADVEAHPVLALTREWEALEDEERAKSARAMEVYAAMVER 289 Query: 261 IDDSIGKILELLQDLHVADNTFVFFTSDNGAA---LISAPEQG----------------- 300 +D +IG++++ L+ DNTFV F SDNGA L + P+ G Sbjct: 290 MDWNIGRVVDYLRRQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLDFLDRHYDNSLEN 349 Query: 301 ----------------GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMD 344 + P K T +GG+R PAL +P G +SH ++MD Sbjct: 350 IGRANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQGAISHAFATVMD 409 Query: 345 LFTTSLALAGLTPPSDR-------AIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQ 397 + T L LAG+ P R G + L L G L Sbjct: 410 VTPTLLDLAGVRHPGKRWRGREIAEPRGRSWLGWLSGETEAAHDENTVTGWGLFGMR--- 466 Query: 398 HKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLS 455 W+ P ++ L RDPGE L+ Sbjct: 467 -----AIRQGDWKAVYLPAPVGPA----------------TWQLYDLARDPGEIHDLA 503 >4UPI-A nrPDB Length = 576 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 115/536 (21%), Positives = 182/536 (33%), Gaps = 129/536 (24%) Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 Q NIL ++ D + + L YG TPN+D++A G+ F N Y + PSR + T Sbjct: 27 QNRNILWIMCDQLRFDYLSCYGHERLNTPNIDKLAKRGVRFTNAYVQATVAGPSRMSAYT 86 Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148 GR +R+ T N + E L + L+ G + ++GK H+ RP Sbjct: 87 GRY-VRSHGSTQNGIP------------LRVGEPTLGDHLRDVGMRNVLIGKTHM--RPD 131 Query: 149 FHPLKH----------------GFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYE 192 +K GFD + H Y K R Sbjct: 132 LDGMKRLGIDPDSEIGARVGEGGFDAFDRDDGVHPTGYRKKEPAYNDYLRHAGFQAENPW 191 Query: 193 EFPINLKTG----------------------EANLTQIYLQEALDFIKRQARH-HPFFLY 229 EF N G E + T + A++F++ + P+ + Sbjct: 192 EFWANSAEGKGGENQSGWLLTHADKPARVPEEHSETAYMTRRAMEFMEAAEKDGRPWCAH 251 Query: 230 WAVDATHAPVYASKP--------------------------------------FLGTSQR 251 + H P P F R Sbjct: 252 LSYIKPHWPYIVPAPYHDMFGPDDVKPAVRSDEELKAAHPLFKAMTEEVYSRNFARDEVR 311 Query: 252 GR----YGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFL 307 + Y +++IDD +G++ +Q+ + +NT + FT+D+G L G + ++ Sbjct: 312 EKVIPAYMGLIKQIDDQLGQLFAFMQERGLDENTMIVFTADHGDYL-------GDH--WM 362 Query: 308 CGKQTTFEGGMREPALAWWP---GHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAID 364 K +E + P + + P T G VS L ++DL T + AG PP ++ Sbjct: 363 GEKYLFYEAAAKVPLIIYDPSDKADATRGTVSDALVEMIDLAPTFVDYAGGVPP-MHILE 421 Query: 365 GLNLLPTLLQGRLM-DRPIFYYRGD-TLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQ 422 G +LLP L DR + D + + A L + I C Sbjct: 422 GKSLLPLLHDDDSSWDRQYVFSELDYSNLPARLKLGR---------------DIQDCRAT 466 Query: 423 NVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLS-FASAEYQEALSRITSVVQQHQE 477 V +E P++F L DP E L SAE E R+TS + Sbjct: 467 MVFDGRYKLVEVMGFAPILFDLEVDPDELKDLGRDPSAE--EVRQRLTSALDAWHR 520 >4UPL-A nrPDB Length = 569 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 107/517 (20%), Positives = 168/517 (32%), Gaps = 139/517 (26%) Query: 32 NILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGRL 91 NIL ++ D + W L YG + TP++DR+AA+G+ F Y +P+C SR + TGR Sbjct: 19 NILFIMFDQLRWDYLSCYGHKTLNTPHIDRLAAKGVRFDRAYIQSPICGSSRMSTYTGRY 78 Query: 92 PIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWH--------- 142 +G + E + + L+ AG +VGK H Sbjct: 79 VHSHGASWNGIP-------------LKVGEMTMGDHLRAAGMGCWLVGKTHMRADEEGMA 125 Query: 143 -LGHRPQFHPLKH----GFDEWF----GSPNCHFGPYD---------NKARPNIPVYRDW 184 LG P GFD + P G YD W Sbjct: 126 RLGLEPDSLIGARVAECGFDVFERDDGMLPEGPDGYYDPDGAKEYNKFLRAKGYESDNPW 185 Query: 185 EMVGRYYEEFPINLKTG--------------EANLTQIYLQEALDFIKRQARHHPFFLYW 230 + N+++G E + T A++FI+ + P+ + Sbjct: 186 HDFANSGLDDEGNVQSGWFLKNATRPANIAEEDSETPYLTSRAMEFIE--QQTGPWCCHL 243 Query: 231 AVDATHAPVYASKPFL-------------GTSQRG------------------------- 252 + H P +P+ S+R Sbjct: 244 SYIKPHWPYIVPEPYASMFGPEHVQDVVRSDSERQNAHPLFKAFMDTKVGEAFSRQEVRD 303 Query: 253 ----RYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLC 308 Y +++ DD +G++ + L+D +T + TSD+G L G Sbjct: 304 AVIPAYMGLIKQADDQMGRLFKWLEDTGRMQDTMIVLTSDHGDFL----------GDHWM 353 Query: 309 GKQTTF-EGGMREPALAWWPG---HVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAID 364 G++T F + R P + + P T G V L +DL T + AG P+ ++ Sbjct: 354 GEKTFFHDASTRVPLIIYDPRPEADATRGSVCDALVESIDLAPTFVEAAG-GKPAMHILE 412 Query: 365 GLNLLPTLLQGR---LMDRPIFYYRGDTLMAATLGQHKAH----FWTWTNSWENFRQGID 417 G +L+P L R L D I Y A L F +W+ D Sbjct: 413 GESLIPILHGARDHTLRDHVICEYDFSASPIAHLNDISVRQAVMFMVADKNWKLIHFEAD 472 Query: 418 FCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPL 454 P++F L DP E L Sbjct: 473 -------------------PRPMLFDLKNDPQELVDL 490 >4UG4-A nrPDB Length = 515 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 102/487 (20%), Positives = 166/487 (34%), Gaps = 118/487 (24%) Query: 30 PPNILLLLMDDMGWGDLGVYGEPS-RETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 PNIL++++D + G L G PNL +A F N Y+++PLC+P+RA+ + Sbjct: 8 KPNILIIMVDQLN-GKLFPDGPADFLHAPNLKALAKRSARFHNNYTSSPLCAPARASFMA 66 Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148 G+LP R Y A E IP L++AGY + + GK H Q Sbjct: 67 GQLPSRTRVYDNAA---------EYQSSIP----TYAHHLRRAGYYTALSGKMHFVGPDQ 113 Query: 149 FHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT-Q 207 HGF+E + P D P+ + E + +Y G A +T Q Sbjct: 114 L----HGFEERLTTDIY---PADFGWTPDYR--KPGERIDWWYHNLGSVTGAGVAEITNQ 164 Query: 208 IYLQEALDFIKRQA-----------RHHPFFLYWAVDATHAPVYASKPFLG--------- 247 + + + F+ Q P+ L + H P A + F Sbjct: 165 MEYDDEVAFLANQKLYQLSRENDDESRRPWCLTVSFTHPHDPYVARRKFWDLYEDCEHLT 224 Query: 248 ----------------------------------TSQRGRYGDAVREIDDSIGKILELLQ 273 R Y + +D+ +G++++ L Sbjct: 225 PEVGAIPLDEQDPHSQRIMLSCDYQNFDVTEENVRRSRRAYFANISYLDEKVGELIDTLT 284 Query: 274 DLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAG 333 + D+T + F SD+G L G G + K FEG R P + PG Sbjct: 285 RTRMLDDTLILFCSDHGDML-------GERGLW--FKMNFFEGSARVPLMIAGPGIAPGL 335 Query: 334 QVSHQLGSIMDLFTTSLALAGLTPPSDRA-IDGLNLLPTLLQGRLMDRPIFYYRGDTLMA 392 ++ S +D+ T LAG++ R DG++L+P + + + Y + A Sbjct: 336 HLT--PTSNLDVTPTLADLAGISLEEVRPWTDGVSLVPMVNGVERTEPVLMEYAAEASYA 393 Query: 393 ATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERF 452 + W+ +D +F L DP E Sbjct: 394 PLV-------AIREGKWKYVYCALD--------------------PEQLFDLEADPLELT 426 Query: 453 PLSFASA 459 L+ Sbjct: 427 NLAENPR 433 >4MHX-A nrPDB Length = 510 Score = 222 bits (564), Expect = 5e-58, Method: Composition-based stats. Identities = 133/519 (25%), Positives = 192/519 (36%), Gaps = 134/519 (25%) Query: 27 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAAL 86 +P N LLLL DD G+ G Y + TP+LD +A LLF N +++ SPSRA+L Sbjct: 19 RARPRNALLLLADDGGFES-GAYNNSAIATPHLDALARRSLLFRNAFTSVSSSSPSRASL 77 Query: 87 LTGRLPIRNGFY--TTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG 144 LTG +NG Y + H N++ D + LP LL +AG + I+GK H+G Sbjct: 78 LTGLPQHQNGMYGLHQDVHHFNSF----------DKVRSLPLLLSQAGVRTGIIGKKHVG 127 Query: 145 HRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEAN 204 + P+D Y EE L+ G N Sbjct: 128 PETVY-------------------PFDFA----------------YTEENGSVLQVGR-N 151 Query: 205 LTQIYLQEALDFIKRQARHHPFFLYWAVDATH-----APVYA---SKPFLGTSQRGRYGD 256 +T+I L F++ Q PFFLY A H P Y K G S GR D Sbjct: 152 ITRIKLL-VRKFLQTQD-DRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPD 209 Query: 257 --------------------------------AVREIDDSIGKILELLQDLHVADNTFVF 284 V +D +G +L+ L+D V ++T V Sbjct: 210 WTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVI 269 Query: 285 FTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTA-GQVSHQLGSIM 343 FTSDNG PF G+ + G EP L P H GQVS S++ Sbjct: 270 FTSDNGI-------------PFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLL 316 Query: 344 DLFTTSLALAGLTPPS-------DRAIDGLNLLPTLLQGRLMDRPIF----YYRGDTLMA 392 DL T L + PS + G +LLP L + + +F ++ Sbjct: 317 DLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPAL-EAEPLWATVFGSQSHHEVTMSYP 375 Query: 393 ATLGQHKAHFWTWTN--------SWENFRQGIDFCPGQN--VSGVTTHNLED----HTKL 438 QH+ HF N ++F F N +G T +D + + Sbjct: 376 MRSVQHR-HFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRA 434 Query: 439 PL-IFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQ 476 ++ RDP E L+ + + L + + + Q Sbjct: 435 RWELYDRSRDPHETQNLA-TDPRFAQLLEMLRDQLAKWQ 472 >5G2V-A nrPDB Length = 534 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 108/524 (20%), Positives = 182/524 (34%), Gaps = 108/524 (20%) Query: 25 SGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRA 84 + PNI+ ++ DD + YG +TPN+DR+A EG+ F N Y+ N L PSRA Sbjct: 23 KEETKRPNIIFMMTDDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALSGPSRA 82 Query: 85 ALLTGRLPIRNGFYTTNAHARN-----------------------------------AYT 109 +LTG+ NGF T NA N + Sbjct: 83 CILTGKFSHENGF-TDNASTFNGDQQTFPKLLQQAGYQTAMIGKWHLISEPQGFDHWSIL 141 Query: 110 PQEIVGGIPDSEQLL--PELLKKAGYVSKIVGKWHLGH-------RPQFHPLKHGFDE-- 158 + G + + + GY + I+ + +P Sbjct: 142 SGQHEQGDYYDPDFWEDGKHIVEKGYATDIITDKAINFLENRDKNKPFCMMYHQKAPHRN 201 Query: 159 WFGSPNCHFGPYDNKARP---NIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALD 215 W +P H G ++N P N+ + ++ I ++ +E Sbjct: 202 WMPAPR-HLGIFNNTIFPEPANLFDDYEGRGKAAREQDMSIEHTLTNDWDLKLLTREE-- 258 Query: 216 FIKRQARHHPFFLYW----AVDATHAPVYASK---------------PFLGTSQRGRYGD 256 + + + + +Y V YA + + Y Sbjct: 259 -MLKDTTNRLYSVYKRMPSEVQDKWDSAYAQRIAEYRKGDLKGKALISWKYQQYMRDYLA 317 Query: 257 AVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEG 316 V +D++IG++L L+ + DNT + +TSD G L G +G F K+ +E Sbjct: 318 TVLAVDENIGRLLNYLEKIGELDNTIIVYTSDQGFFL-------GEHGWF--DKRFMYEE 368 Query: 317 GMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL-QG 375 R P + +P + AG S + +D T L AG+ PSD I G +L P L +G Sbjct: 369 CQRMPLIIRYPKAIKAGSTSSAISMNVDFAPTFLDFAGVEVPSD--IQGASLKPVLENEG 426 Query: 376 RLMD--RPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLE 433 + R YY A K H+ T ++ D + Sbjct: 427 KTPADWRKAAYYHYYEYPAE--HSVKRHYGIRTQDFKLIHFYNDIDEWE----------- 473 Query: 434 DHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQE 477 ++ + DP E + F AEY + + ++++ Q+ Sbjct: 474 -------MYDMKADPREMNNI-FGKAEYAKKQKELMQLLEETQK 509 >4UPH-A nrPDB Length = 547 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 96/503 (19%), Positives = 164/503 (32%), Gaps = 109/503 (21%) Query: 20 AGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLC 79 + + + PN+LL+ D L G S +TPN+D +A +G+LF ++ Sbjct: 34 TSIEWRPSGKRPNVLLISADQWRGDCLSAVGHASVKTPNVDALAQDGVLFTRHFAGTAPA 93 Query: 80 SPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVG 139 SP+RA L TG + + + + L ++ GY + G Sbjct: 94 SPARATLYTGLYQMNHRVCRNGSPLDARFDN-------------LALAARRGGYDPTLFG 140 Query: 140 KWHLGHRPQ-FHPLKHGFDEWFGSPNCH----FGPYDNKARPNIPVYRDWEMVGRYYEEF 194 P+ P + G P K + R Sbjct: 141 YTDTAPDPRGMDPNDPHLTTYEGVLPGFSARQLLPEHEKQWLSWLRSRGHPEATSRDIHI 200 Query: 195 PINLKTGE-----------ANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHA------ 237 P+ GE T E + ++ Q P+F + + H Sbjct: 201 PVGATPGEISDVAPAYSKDETQTAFLAGEFIRWLGEQDA--PWFAHVSFLRPHPPFSVPE 258 Query: 238 ----------------------------------PVYASKPFLG--------------TS 249 P+ F+ ++ Sbjct: 259 PYNRMFTPSDGPAFARAANREAEQAVHPLLAFALPLIGKDSFIYGGEGSASDWTSEDLSA 318 Query: 250 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG 309 R Y + E+D +G+I + L+++ D+T + FTSD+ E G + ++ G Sbjct: 319 IRAIYYGMIAEVDTQLGRIWQALKNVGAWDDTLIIFTSDHA-------EMMGDH--WMLG 369 Query: 310 KQTTFEGGMREPALAWWPGHV-TAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNL 368 K F+G P + PGH AG+ + S D+F T GL P D +DG L Sbjct: 370 KGGFFDGSYHVPLVIRDPGHPGGAGRQVERFTSAADIFPTLCDRLGLVP--DNHLDGGTL 427 Query: 369 LPTLLQGRLMD-RPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGV 427 +P L G R ++ D G+ + HF +N+ + + +G+ Sbjct: 428 VPFLEGGEPEGWRDAAFWEFD-FRDIAKGEAERHFGLKSNACNLAVIRDERFKYVHFAGL 486 Query: 428 TTHNLEDHTKLPLIFHLGRDPGE 450 PL++ L +DP E Sbjct: 487 ----------PPLLYDLAKDPME 499 >2VQR-A nrPDB Length = 543 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 110/521 (21%), Positives = 170/521 (32%), Gaps = 117/521 (22%) Query: 15 LVLSAAGMGASGAPQPPNILLLLMDDMGWG----DLGVYGEPS-RETPNLDRMAAEGLLF 69 + S++ G + + N+LL+++D L G+ +TPNLDR+ EG+ F Sbjct: 17 VPNSSSVPGDPSSMRKKNVLLIVVDQWRADFVPHVLRADGKIDFLKTPNLDRLCREGVTF 76 Query: 70 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK 129 N + P+RA+LLTG Y N A P + L + L+ Sbjct: 77 RNHVTTCVPAGPARASLLTG-------LYLMNHRAVQNTVP------LDQRHLNLGKALR 123 Query: 130 KAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDW----- 184 GY ++G P+ G F P PN+ Y W Sbjct: 124 GVGYDPALIGYTTTVPDPRTTSPNDPRFRVLGDLMDGFHPV-GAFEPNMEGYFGWVAQNG 182 Query: 185 ----EMVGRYYEEFPINLKTGEANLTQI----------YLQEALDFIKRQARHHPFFLYW 230 E + + G + + + AL ++K + PFFL+ Sbjct: 183 FDLPEHRPDIWLPEGEDAVAGATDRPSRIPKEFSDSTFFTERALTYLKGRD-GKPFFLHL 241 Query: 231 AVDATH-------------------APVYASKPFLG------------------------ 247 H AP+ A+ P + Sbjct: 242 GYYRPHPPFVASAPYHAMYRPEDMPAPIRAANPDIEAAQHPLMKFYVDSIRRGSFFQGAE 301 Query: 248 -----------TSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISA 296 R Y + E+DD +G++ L + D+T + FTSD+G Sbjct: 302 GSGATLDEAELRQMRATYCGLITEVDDCLGRVFSYLDETGQWDDTLIIFTSDHG------ 355 Query: 297 PEQGGSNGPFLCGKQTTFEGGMREPALAWWPG-HVTAGQVSHQLGSIMDLFTTSLALAGL 355 EQ G + L GK + R P + G + AG + +D+ T L G Sbjct: 356 -EQLGDH--HLLGKIGYNDPSFRIPLVIKDAGENARAGAIESGFTESIDVMPTILDWLGG 412 Query: 356 TPPSDRAIDGLNLLPTLLQGRLMD-RPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQ 414 P A DGL+LLP L +GR D R +Y D + Sbjct: 413 KIP--HACDGLSLLPFLSEGRPQDWRTELHYEYD----FRDVYYS-------EPQSFLGL 459 Query: 415 GIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLS 455 G++ C + + PL F L DP E L+ Sbjct: 460 GMNDCSLCVIQDERYKYVHFAALPPLFFDLRHDPNEFTNLA 500 >6IOZ-A nrPDB Length = 517 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 85/398 (21%), Positives = 146/398 (36%), Gaps = 78/398 (19%) Query: 32 NILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGRL 91 N+LL+++DD+ LG YG+ +PN+D++A+ LLF N ++ + +PSR + LTGR Sbjct: 5 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVAAPSRVSFLTGRR 63 Query: 92 PIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFHP 151 P Y N+ + +P+ K+ GYV+ VGK H Sbjct: 64 PDTTRLYDFNS----------YWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHT 113 Query: 152 LKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQ 211 + F + Y+N P +++ G Q + Sbjct: 114 DDSPYSWSFPPYHPSSEKYENTKTCRGP--DGELHANLLCPVDVLDVPEGTLPDKQS-TE 170 Query: 212 EALDFIKR-QARHHPFFLYWAVDATHAPVYASKPFLG----------------------- 247 +A+ +++ + PFFL H P K F Sbjct: 171 QAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVA 230 Query: 248 ------------------------------TSQRGRYGDAVREIDDSIGKILELLQDLHV 277 R Y +V +D +G++L L DL + Sbjct: 231 YNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQL 290 Query: 278 ADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTA-GQVS 336 A++T + FTSD+G AL G +G + K + F+ P + + PG + + Sbjct: 291 ANSTIIAFTSDHGWAL-------GEHGEW--AKYSNFDVATHVPLIFYVPGRTASLPEAG 341 Query: 337 HQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQ 374 +L +D F ++ L S ++ ++L PTL Sbjct: 342 EKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAG 379 >2W8S-A nrPDB Length = 543 Score = 200 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 118/562 (20%), Positives = 181/562 (32%), Gaps = 122/562 (21%) Query: 15 LVLSAAGMGASGAPQPPNILLLLMDDMGWGD----LGVYGEPS-RETPNLDRMAAEGLLF 69 + S++ G + N+LL+++D + G +TPNLDR+ EGL F Sbjct: 17 VPNSSSVPGDPSSMTRKNVLLIVVDQWRADFIPHLMRAEGREPFLKTPNLDRLCREGLTF 76 Query: 70 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK 129 N + P+RA+LLTG Y N A P + L + L+ Sbjct: 77 RNHVTTCVPGGPARASLLTG-------LYLMNHRAVQNTVP------LDQRHLNLGKALR 123 Query: 130 KAGYVSKIVGKWHLGHR-----------PQFHPLKHGFDEWFGSPNCHFGPYDNKARP-- 176 GY ++G + GF G + A+ Sbjct: 124 AIGYDPALIGYTTTTPDPRTTSARDPRFTVLGDIMDGFRSVGAFEPNMEGYFGWVAQNGF 183 Query: 177 NIPVYRDWEMVGRYYEEFPINLKT-----GEANLTQIYLQEALDFIKRQARHHPFFLYWA 231 +P R+ + P E + + + + AL ++K + PFFL+ Sbjct: 184 ELPENREDIWLPEGEHSVPGATDKPSRIPKEFSDSTFFTERALTYLKGRD-GKPFFLHLG 242 Query: 232 VDATH-------------------APVYASKPFLG------------------------- 247 H AP+ A P Sbjct: 243 YYRPHPPFVASAPYHAMYKAEDMPAPIRAENPDAEAAQHPLMKHYIDHIRRGSFFHGAEG 302 Query: 248 ----------TSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAP 297 R Y + EIDD +G++ L + D+T + FTSD+G Sbjct: 303 SGATLDEGEIRQMRATYCGLITEIDDCLGRVFAYLDETGQWDDTLIIFTSDHG------- 355 Query: 298 EQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVT-AGQVSHQLGSIMDLFTTSLALAGLT 356 EQ G + L GK R P + G AGQ+ +D+ T L G Sbjct: 356 EQLGDH--HLLGKIGYNAESFRIPLVIKDAGQNRHAGQIEEGFSESIDVMPTILEWLGGE 413 Query: 357 PPSDRAIDGLNLLPTLLQGRLMD-RPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQG 415 P RA DG +LLP L +G+ D R +Y D + F+ + + + Sbjct: 414 TP--RACDGRSLLPFLAEGKPSDWRTELHYEFD---------FRDVFYDQPQN--SVQLS 460 Query: 416 IDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFAS------AEY-QEALSRI 468 D C + + PL F L DP E L+ +Y Q+ALS Sbjct: 461 QDDCSLCVIEDENYKYVHFAALPPLFFDLKADPHEFSNLAGDPAYAALVRDYAQKALSWR 520 Query: 469 TSVVQQHQEALVPAQPQLNVCN 490 S + + L N Sbjct: 521 LSHADRTLTHYRSSPQGLTTRN 542 >5G2T-A nrPDB Length = 489 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 87/477 (18%), Positives = 169/477 (35%), Gaps = 68/477 (14%) Query: 23 GASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPS 82 + PN L++ D + +G YG+ T +D +A+ G++F N Y PL PS Sbjct: 16 QGLRQQEKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPLSQPS 75 Query: 83 RAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWH 142 RAAL +G +P + + ++ N +P++ L L ++GY + GK H Sbjct: 76 RAALWSGMMPHQTNVRSNSSEPVNTR--------LPENVPTLGSLFSESGYEAVHFGKTH 127 Query: 143 ----LGHRPQFHPLKHGF---------DEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGR 189 L P+ F D + C P P + Sbjct: 128 DMGSLRGFKHKEPVAKPFTDPEFPVNNDSFLDVGTCEDAVAYLSNPPKEPFICIADFQNP 187 Query: 190 YYEEFPINLKTG---EANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFL 246 + I G + ++ + +F + P + + + H + + + Sbjct: 188 HNICGFIGENAGVHTDRPISGPLPELPDNFDVEDWSNIPTPVQYICCS-HRRMTQAAHWN 246 Query: 247 GTSQRGRYGDAVRE---IDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSN 303 + R + + +L+ L NT V +D+G + ++ + Sbjct: 247 EENYRHYIAAFQHYTKMVSKQVDSVLKALYSTPAGRNTIVVIMADHGDGM-ASHRMVTKH 305 Query: 304 GPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLG--SIMDLFTTSLALAGLTPPSDR 361 + ++ P + PG + L +DL T LAG+ P+++ Sbjct: 306 -------ISFYDEMTNVPFIFAGPGIKQQKKPVDHLLTQPTLDLLPTLCDLAGIAVPAEK 358 Query: 362 AIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWT---WTNSWENFRQGIDF 418 A G++L PTL + Q K+H + W + +E Sbjct: 359 A--GISLAPTLRGEK--------------------QKKSHPYVVSEWHSEYEYVTT--PG 394 Query: 419 CPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQH 475 + TH LE + + ++ + +DPGER L+ +Y + L+ +++ + Sbjct: 395 RMVRGPRYKYTHYLEGNGEE--LYDMKKDPGERKNLA-KDPKYSKILAEHRALLDDY 448 >4UPK-A nrPDB Length = 538 Score = 151 bits (380), Expect = 9e-37, Method: Composition-based stats. Identities = 78/425 (18%), Positives = 128/425 (30%), Gaps = 104/425 (24%) Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88 + N+L +++D + L E P+L +A + + F YS C PSRA++LT Sbjct: 32 RQSNVLFIIIDQLRADCLWGALADHVELPHLRALAQDAVSFRRHYSVTNPCGPSRASILT 91 Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148 G+ N + TP + + ++KAGY+ + G P+ Sbjct: 92 GQY-------AMNHRSVRNGTP------LRHDTPNIATEMRKAGYLPLLFGYTDTSQDPR 138 Query: 149 FHP-----------LKHGFDE-----------WFGSPNCHFGPYDNKARPNIPVYRDWEM 186 + GF E W +D+ A+ +P Sbjct: 139 AYDANDPALKTYEFPMRGFHEVTEMRLEMSYPWQSHLKNRGYAFDDYAQVYVPRPDADGT 198 Query: 187 VGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFL 246 + A LT +L + + +F + H P+ A P+ Sbjct: 199 PRLNGPAMYRAEDSDTAFLTDQFLANMPAWAGQN-----WFAHLTYIRPHPPLVAPAPYN 253 Query: 247 GTSQ----------------------------------------------------RGRY 254 R Y Sbjct: 254 TMYDPAKLPLPARLPGRDDETAEHPFFGPATRYSSPASFVLGFPDLEPTDETIQTLRAVY 313 Query: 255 GDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTF 314 E+D IG+++ L++ D+T + T+D+G L GK T + Sbjct: 314 LGLATEVDTHIGRVIAHLKETGQYDDTLIVVTADHGEMLGDRHS---------WGKMTVY 364 Query: 315 EGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQ 374 + P + PG G V +DL T L G P A+DG +L P L Sbjct: 365 DAAYHTPLIIRAPG-CKPGHVVEAPTESIDLMPTILDWVGQEIP--NAVDGRSLRPFLTG 421 Query: 375 GRLMD 379 D Sbjct: 422 EAPSD 426 >3LXQ-A nrPDB Length = 450 Score = 98.0 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 65/364 (17%), Positives = 123/364 (33%), Gaps = 62/364 (17%) Query: 24 ASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSR 83 A+ + N+++LL + +G +G G TPNLD + EG F Y+ Sbjct: 79 ATYQGKRKNLVILLQESLGAQFVGSLGGLPL-TPNLDELMQEGWQFTQMYATGTRSVRGI 137 Query: 84 AALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHL 143 A+ TG P + + ++ + + +LLK+ GY ++ + Sbjct: 138 EAVTTGFPPSPSRAVVKLSKSQTGFF-------------TIADLLKEQGYHTQFI----Y 180 Query: 144 GHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEA 203 G F +K F FG+ N P Sbjct: 181 GGEANFDNMKTFF---FGNGFDQIVEEKNYTNPGF----VGSWG---------------V 218 Query: 204 NLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLG--TSQRGRYGDAVREI 261 + +Y + +F + PFF + H+P + + S+ +AV+ Sbjct: 219 SDEDLYNKADEEFERLSKGDKPFFSLVFTSSNHSPYEYPEGKIEQYDSEHMTRNNAVKYS 278 Query: 262 DDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREP 321 D ++G + + D+T +D+ A + A + P Sbjct: 279 DYALGTFFDKAKKSSYWDDTIFIVIADHDARVFGANLVPVKH--------------FHIP 324 Query: 322 ALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRP 381 AL G + ++ + +D+ T L+L G+ + + G +L L R +R Sbjct: 325 ALII--GKDIQPRKDDRIANNIDMPPTLLSLIGV--DAKTPMIGRDLTKPL--AREDERA 378 Query: 382 IFYY 385 + Y Sbjct: 379 MMQY 382 >4UOP-A nrPDB Length = 442 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 64/364 (17%), Positives = 131/364 (35%), Gaps = 70/364 (19%) Query: 26 GAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRA- 84 GA + N++++ ++ V TP LD + E + F+ + + A Sbjct: 53 GAAKGKNLIIVQLESFQRNLTNVKINGQSITPTLDGLQNETMYSNQFFQTVSKSNTADAE 112 Query: 85 -ALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHL 143 ++ T P +G+YT + P +P LL K Y + H Sbjct: 113 WSVYTSTFP--SGYYTNTQTYGDRVIPS------------MPRLLGKNDYKTATF---HT 155 Query: 144 GH-----RPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINL 198 R +F+P GFD+++ + + D +++G + Sbjct: 156 NDASFYNRDEFYP-AVGFDKFY----------------DRKFFGDEDVIGFSPSD----- 193 Query: 199 KTGEANLTQIYLQEALDFIKRQ-ARHHPFFLYWAVDATHAPVYASKP--------FLGTS 249 ++ +A ++ Q + F+ ++H P K L + Sbjct: 194 --------EVLYNKAFPILEEQYKNNQKFYAQLISVSSHMPFDIPKDKQEIDLPSDLKDT 245 Query: 250 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG 309 + G Y +AV D +G+ ++ L+D + D++ V F D+ +I + ++ Sbjct: 246 ELGNYFEAVHYADKQLGEFIQKLKDSGIWDDSVVVFYGDH--HIIKTDQLPEEQKKYVNR 303 Query: 310 KQTTFEG---GMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGL 366 R P +PG G++ + G +D+ T + L G+ D+ + G Sbjct: 304 STQLKAEPADDYRIPFFLHYPGMENPGEIKNVGGE-IDIMPTVMNLLGIKT-GDQIMFGT 361 Query: 367 NLLP 370 ++L Sbjct: 362 DILN 365 >2W8D-A nrPDB Length = 436 Score = 71.4 bits (173), Expect = 9e-13, Method: Composition-based stats. Identities = 62/375 (16%), Positives = 120/375 (32%), Gaps = 63/375 (16%) Query: 26 GAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMA--AEGLLFPNFYSANPLCSPSR 83 G + N++ + ++ + + + TP L+++A E F NF+ S Sbjct: 27 GKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKLAHDNETFYFDNFFHQTGQGKTSD 86 Query: 84 AALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHL 143 A + + N Y + Q + Q +P +LK Y S Sbjct: 87 AEFM-----MENSLYPLAQGSVFVNKAQNTL-------QSVPAILKSKNYTSA------- 127 Query: 144 GHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEA 203 + G+ + N+ D YY+ N K Sbjct: 128 --------------TFHGNTQ----TFWNRNEMYKAEGIDKFFDSAYYDMNEENTKN-YG 168 Query: 204 NLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPV--------YASKPFLGTSQRGRYG 255 + + +E++ ++ + PF+ + + H P + + F G S Y Sbjct: 169 MKDKPFFKESMPLLESLPQ--PFYTKFITLSNHFPFGMDEGDTDFPAGDF-GDSVVDNYF 225 Query: 256 DAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFE 315 + +D SI + L+ + D + + D+ IS + T ++ Sbjct: 226 QSAHYLDQSIEQFFNDLKKDGLYDKSIIVMYGDH--YGISENHNKAMAKVLGKDEITDYD 283 Query: 316 GG--MREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL 373 R P G G+ H+ +D+ T L L G+ D + G ++L Sbjct: 284 NAQLQRVPLFIHAAGV--KGEKVHKYAGDVDVAPTILHLLGVDT-KDYLMSGSDIL---- 336 Query: 374 QGRLMDRPIFYYRGD 388 + I + GD Sbjct: 337 -SKEHREVIPFRNGD 350 >5I5H-A nrPDB Length = 586 Score = 70.6 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 65/387 (16%), Positives = 114/387 (29%), Gaps = 95/387 (24%) Query: 32 NILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGRL 91 N+LL+ +D + Y ++ P L A + + F S Sbjct: 261 NVLLITVDGLN------YSRFEKQMPALAGFAEQNISFTRHMS----------------- 297 Query: 92 PIRNGFYTTNA--HARNAYTPQEIVGGIPDSEQL-LPELLKKAGYVSKIVGKWHLGHRPQ 148 +G T N +P + G + L L + GY + Sbjct: 298 ---SGNTTDNGIFGLFYGISPSYMDGILSTRTPAALITALNQQGYQLGLF---------- 344 Query: 149 FHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQI 208 GF SP + + P++ D + ++ Sbjct: 345 ---SSDGFT----SPLYRQALLSDFSMPSVRTQSDEQTATQW------------------ 379 Query: 209 YLQEALDFIKR-QARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGK 267 ++++ R + +F + + + T+ + F R A +DD I + Sbjct: 380 -----INWLGRYAQEDNRWFSWVSFNGTNIDDSNQQAFARKYSR-----AAGNVDDQINR 429 Query: 268 ILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWP 327 +L L+D DNT V T+ G L E + L + P + WP Sbjct: 430 VLNALRDSGKLDNTVVIITAGRGIPLSEEEETFDWSHGHL-----------QVPLVIHWP 478 Query: 328 GHVTAGQVSHQLGSIMDLFTTSLA-LAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYR 386 G T Q + L DL TT + L ++ P+ G +L R + Sbjct: 479 G--TPAQRINALTDHTDLMTTLMQRLLHVSTPASEYSQGQDLFN------PQRRHYWVTA 530 Query: 387 GDTLMAATLGQHKAHFWTWTNSWENFR 413 D A K + + Sbjct: 531 ADNDTLAITTPKKTLVLNNNGKYRTYN 557 >5I5F-A nrPDB Length = 586 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 73/209 (34%), Gaps = 28/209 (13%) Query: 203 ANLTQIYLQEALDFIK----RQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAV 258 A TQ Q A +I + +F + + + T+ K F+ RY A Sbjct: 366 AAQTQSDAQTASQWIDWLGRYAQEDNRWFSWISFNGTNIDDSNQKNFVK-----RYASAA 420 Query: 259 REIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGM 318 ++D I ++L L++ DNT V T+ G L + + +G + Sbjct: 421 SDVDAQINRVLNALREAGKFDNTVVIITAGRGIPLTPEE----NRFDWS-------QGHL 469 Query: 319 REPALAWWPGHVTAGQVSHQLGSIMDLFTTSLA-LAGLTPPSDRAIDGLNLLPTLLQGRL 377 + P + WPG T Q + L D+ TT + L ++ P++ G ++ Sbjct: 470 QVPLVIHWPG--TPAQRINVLTDHTDVMTTLMQRLLHVSTPANEYSQGQDIFTV-----P 522 Query: 378 MDRPIFYYRGDTLMAATLGQHKAHFWTWT 406 + +A T Q Sbjct: 523 RRHNWVTAADGSTLAITTPQMTLVLNNNG 551 >2W5S-A nrPDB Length = 424 Score = 66.0 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 58/378 (15%), Positives = 127/378 (33%), Gaps = 68/378 (17%) Query: 26 GAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFP---NFYSANPLCSPS 82 G + NI+ + ++ + TP L+++++ F NF+ Sbjct: 25 GVAKKKNIIKIHLESFQTFLINKKVNGKEVTPFLNKLSSGKEQFTYFPNFFHQ------- 77 Query: 83 RAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELL-KKAGYVS-KIVGK 140 TG+ + +T + ++ Q LP +L +K GY S + G Sbjct: 78 -----TGQGKTSDSEFTMDNSLYGLPQGSAFSLKGDNTYQSLPAILDQKQGYKSDVMHGD 132 Query: 141 WHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKT 200 + G D+++ + Y + Sbjct: 133 YKTFWNRDQVYKHFGIDKFYDATY-------------------------YDMSDKNVVNL 167 Query: 201 GEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY-------ASKPFLGTSQRGR 253 G + +I+ +++ ++ + PF+ + H P K G + Sbjct: 168 GLKD--KIFFKDSANY--QAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDG 223 Query: 254 YGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTT 313 Y R +D+++ + + L+ + DN+ + D+ E + L G++ T Sbjct: 224 YIQTARYLDEALEEYINDLKKKGLYDNSVIMIYGDH----YGISENHNNAMEKLLGEKIT 279 Query: 314 ---FEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLP 370 F R PG +G ++++ +D+ T L LAG+ + + G +L Sbjct: 280 PAKFTDLNRTGFWIKIPG--KSGGINNEYAGQVDVMPTILHLAGIDT-KNYLMFGTDLF- 335 Query: 371 TLLQGRLMDRPIFYYRGD 388 + ++ + + GD Sbjct: 336 ----SKGHNQVVPFRNGD 349 >4UOO-A nrPDB Length = 459 Score = 63.3 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 47/331 (14%), Positives = 98/331 (29%), Gaps = 58/331 (17%) Query: 26 GAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE--GLLFPNFYSANPLCSPSR 83 G + N++ + ++ + TP ++ + L F NF+ Sbjct: 56 GKAKGKNVIYIHLESFQQFLVNYKLNGEEVTPFINSFFKDQNTLSFTNFFHQ-------- 107 Query: 84 AALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHL 143 TG+ + ++ + +L + GY S + Sbjct: 108 ----TGQGKTADSEMLLENSLYGLPQGSAFTTKGQNTYESASAILGQQGYTSAVF----- 158 Query: 144 GHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEA 203 + ++ + N+ D YY+ ++ Sbjct: 159 --------------------HGNYKSFWNRDEIYKQFGYDNFFDASYYDMNEADVSN-YG 197 Query: 204 NLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYAS-------KPFLGTSQRGRYGD 256 + + +E+ +++ + PF+ + H P G S Y Sbjct: 198 LKDKPFFKESEEYLS--SLQQPFYTKFITLTNHFPYPIDEKDASIAPATTGDSSVDTYFQ 255 Query: 257 AVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQ-TTFE 315 R +D+S+ ++ L+ + DN+ + D+ + + GK TFE Sbjct: 256 TARYLDESVKSFVDYLKKSGLYDNSVIIMYGDH----YGISDNHEEAMTKILGKDYNTFE 311 Query: 316 --GGMREPALAWWPGHVTAGQVSHQLGSIMD 344 R P + PG G V Q G +D Sbjct: 312 NAQAQRVPLMIHVPGV--QGGVQEQYGGQVD 340 >5UDY-A nrPDB Length = 422 Score = 58.7 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 55/336 (16%), Positives = 107/336 (31%), Gaps = 56/336 (16%) Query: 20 AGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLL---FPNFYSAN 76 A + + G+ +LL+ D W + +TPNLD MA +G+ + Sbjct: 11 APVQSQGSQNK--LLLVSFDGFRWNY-----DQDVDTPNLDAMARDGVKARYMTPAFV-- 61 Query: 77 PLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSK 136 + SP L+TG+ +G + + + + + + Sbjct: 62 TMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGI----------QRWWDNG 111 Query: 137 IVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPI 196 V W Q L+ G F P N + V R + + + Sbjct: 112 SVPIW---ITAQRQGLRAG---------SFFYPGGNVTYQGVAVTRSRKEGIAHNYKNET 159 Query: 197 NLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGD 256 + + + +E LD + LY+ + Y + Sbjct: 160 EWRANIDTVMAWFTEEDLDLV---------TLYFGEPDSTGHRYGPESPERRE------- 203 Query: 257 AVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEG 316 VR++D ++G + E + H+ D + TSD+G + + ++ G F TF Sbjct: 204 MVRQVDRTVGYLRESIARNHLTDRLNLIITSDHG--MTTVDKRAGDLVEFHKFPNFTFRD 261 Query: 317 GMREPALAWWPG---HVTAGQVSHQLGSIMDLFTTS 349 + L + P G++ ++ D Sbjct: 262 -IEFELLDYGPNGMLLPKEGRLEKVYDALKDAHPKL 296 >5KGM-A nrPDB Length = 552 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 31/133 (23%), Positives = 52/133 (39%), Gaps = 21/133 (15%) Query: 240 YASKPFLGTSQRGRYGDAVRE---IDDSIGKILELLQDLHVADNTFVFFTSDNGAALISA 296 +A +G + G Y AV+ D +IG+I E Q + + T+D+G A Sbjct: 422 FAPPDMVGHT--GVYEAAVKACEATDIAIGRIYEATQKHGYS----LMVTADHGNAEKMK 475 Query: 297 PEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLT 356 GG + C R P PG + D+ T LA+ GL Sbjct: 476 APDGGKHTAHTC---------YRVPLTLSHPGFKFVDPADRHPA-LCDVAPTVLAIMGLP 525 Query: 357 PPSDRAIDGLNLL 369 P++ + G++++ Sbjct: 526 QPAE--MTGVSIV 536 >5XWI-A nrPDB Length = 567 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 55/331 (16%), Positives = 97/331 (29%), Gaps = 66/331 (19%) Query: 27 APQPPNILL-LLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCS--PSR 83 A PP +++ + +D Y T L R+ +EG +FP Y ++ P Sbjct: 36 AATPPKLIVAISVDQFSADLFSEY--RQYYTGGLKRLTSEGAVFPRGYQSHAATETCPGH 93 Query: 84 AALLTGRLPIRNGFYTTN------------------AHARNAYTPQEIVGGIPDSEQLLP 125 + +LTG P R G N + + + + L Sbjct: 94 STILTGSRPSRTGIIANNWFDLDAKREDKNLYCAEDESQPGSSSDKYEASPLHLKVPTLG 153 Query: 126 ELLKKAGYVSKIV---GK---------------WHLGHRPQFHPLKHGFDEWFGSPNCHF 167 +K A +++V GK W LG PQ + G + Sbjct: 154 GRMKAANPATRVVSVAGKDRAAIMMGGATADQVWWLGG-PQGYVSYKGVAPTPLVTQVNQ 212 Query: 168 GPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDF--IKRQARHHP 225 A+PN + V + + N G T + ++A D+ + Sbjct: 213 AFAQRLAQPNPGFELPAQCVSKDFPVQAGNRTVG----TGRFARDAGDYKGFRISPEQDA 268 Query: 226 FFLYWAVDATHAPVYASKPFLG--------TSQRGRYGDA--------VREIDDSIGKIL 269 L +A A + T G V +D +G Sbjct: 269 MTLAFAAAAIENMQLGKQAQTDIISIGLSATDYVGHTFGTEGTESCIQVDRLDTELGAFF 328 Query: 270 ELLQDLHVADNTFVFFTSDNGAALISAPEQG 300 + L + + V T+D+G + + Sbjct: 329 DKLDKDGI--DYVVVLTADHGGHDLPERHRM 357 >4B56-A nrPDB Length = 820 Score = 45.6 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 42/267 (15%), Positives = 88/267 (32%), Gaps = 47/267 (17%) Query: 25 SGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCS-PSR 83 + PP +L L D L +G P + ++ G N P + P+ Sbjct: 101 AEFESPPTLLFSL-DGFRAEYLHTWGGLL---PVISKLKNCGTYTKNMRPMYPTKTFPNH 156 Query: 84 AALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHL 143 +++TG P +G Y K+ + L Sbjct: 157 YSIVTGLYPESHGIIDNKM------------------------------YDPKMNASFSL 186 Query: 144 GHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEA 203 + +F+PL + + + N P V D + Y + G Sbjct: 187 KSKEKFNPLWYKGQPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIY------KVYNGSV 240 Query: 204 NLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDD 263 + L L++++ + P F ++ + ++ P + A++++D Sbjct: 241 PFEERILA-VLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSSEVIK-----ALQKVDR 294 Query: 264 SIGKILELLQDLHVADNTFVFFTSDNG 290 +G +++ L+DL + + SD+G Sbjct: 295 LVGMLMDGLKDLGLDKCLNLILISDHG 321 >4LR2-A nrPDB Length = 401 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 45/270 (16%), Positives = 78/270 (28%), Gaps = 54/270 (20%) Query: 25 SGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFP---NFYSANPLCSP 81 S + PP +LL+ D L Y E P+L EG+L N + P Sbjct: 5 SSSSLPPKLLLVSFDGFRADYLKNY-----EFPHLQNFIKEGVLVEHVKNVFITKTF--P 57 Query: 82 SRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKW 141 + +++TG +G + + V K Sbjct: 58 NHYSIVTGLYEESHGIVANSMYD--------------------------------AVTKK 85 Query: 142 HLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTG 201 H P F P ++ ++ Sbjct: 86 HFSDSNDKDP----FWWNEAVPIWVTNQLQENRSSAAAMWPGTDVPIHDTISSYFMNYNS 141 Query: 202 EANLTQIYLQEALDFIKRQARHHPF-FLYWAVDATHAPVYASKPFLGTSQRGRYGDAVRE 260 + + L ++ F LYW Y + S+ +++ Sbjct: 142 SVSFEER-LNNITMWLNNSNPPVTFATLYWEEPDASGHKYGPEDKENMSR------VLKK 194 Query: 261 IDDSIGKILELLQDLHVADNTFVFFTSDNG 290 IDD IG +++ L+ L + +N V TSD+G Sbjct: 195 IDDLIGDLVQRLKMLGLWENLNVIITSDHG 224 >6C01-A nrPDB Length = 838 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 41/276 (14%), Positives = 82/276 (29%), Gaps = 57/276 (20%) Query: 24 ASGAPQP-----PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPL 78 A + P P ++L MD L + PN++++ G+ + P Sbjct: 110 AQQSQCPEGFDLPPVILFSMDGFRAEYLYTW---DTLMPNINKLKTCGIHSKYMRAMYPT 166 Query: 79 CS-PSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKI 137 + P+ ++TG P +G N + N + + Sbjct: 167 KTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSL-SSKEQNNPAW------------- 212 Query: 138 VGKWH---LGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEF 194 WH + + LK W GS G + + P Sbjct: 213 ---WHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMP------------------ 251 Query: 195 PINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRY 254 G + L ++ P F + + +A P R Sbjct: 252 ----YNGSVPFEERI-STLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVS-----ARV 301 Query: 255 GDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNG 290 A++ +D + G ++E L+ ++ + + +D+G Sbjct: 302 IKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHG 337 >6G4G-A nrPDB Length = 840 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 47/293 (16%), Positives = 92/293 (31%), Gaps = 47/293 (16%) Query: 25 SGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCS-PSR 83 G QPP IL + D L + S PN++++ GL + P + P+ Sbjct: 111 EGFDQPPVILFSM-DGFRAEYLQTW---STLLPNINKLKTCGLHSKYMRAVYPTKTFPNH 166 Query: 84 AALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHL 143 ++TG P +G N + + + + +++ + Sbjct: 167 YTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWS---GQPIWLTAM------ 217 Query: 144 GHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEA 203 + LK W GS G + N R N Sbjct: 218 -----YQGLKAASYYWPGSDVAVNGSFPNIYR---------------------NYSNSVP 251 Query: 204 NLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDD 263 ++I L ++ P F V+ + + S P + A++ +DD Sbjct: 252 YESRIAT--LLQWLDLPKAERPSFYTIYVEEPDSAGHKSGPVSAGVIK-----ALQLVDD 304 Query: 264 SIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEG 316 + G ++E L+ ++ + + +D+G S F ++G Sbjct: 305 AFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPEINFYMYQG 357 >4LR8-A nrPDB Length = 416 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 24/106 (22%), Positives = 40/106 (37%), Gaps = 20/106 (18%) Query: 254 YGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTT 313 YG+A++E D + ++ L++ + + T+D+G N P G T Sbjct: 320 YGEALQEYDARLPEVFAKLKE-----DDLLLITADHG------------NDPIHPGTDHT 362 Query: 314 FEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPS 359 E P LA+ P GQ + D+ T G+ P Sbjct: 363 RE---YVPLLAYSPSMKEGGQELPLRQTFADIGATVAENFGVKMPE 405 >1O99-A nrPDB Length = 511 Score = 42.5 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 29/131 (22%), Positives = 48/131 (36%), Gaps = 21/131 (16%) Query: 240 YASKPFLGTSQR-GRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPE 298 YA+ +G S + AV +D+ +GK+++ + +A T+D+G Sbjct: 399 YANPDMVGHSGKLEPTIKAVEAVDECLGKVVDAI----LAKGGIAIITADHG-------- 446 Query: 299 QGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPP 358 GK T P + G G + DL T L L GL P Sbjct: 447 -NADEVLTPDGKPQTAHTTNPVPVIV-----TKKGIKLRDGGILGDLAPTMLDLLGLPQP 500 Query: 359 SDRAIDGLNLL 369 + + G +L+ Sbjct: 501 --KEMTGKSLI 509 >5MX9-A nrPDB Length = 324 Score = 41.8 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 25/105 (23%), Positives = 40/105 (38%), Gaps = 9/105 (8%) Query: 254 YGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTT 313 Y +A+ DD I K ++ L+ + + + SD+G E G NG +L G Sbjct: 215 YDNALLATDDFIAKSIDWLKTHEANYDVAMLYVSDHG-------ESLGENGVYLHGMPNA 267 Query: 314 FEGGMR--EPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLT 356 F + PA W S + + + T L L +T Sbjct: 268 FAPKEQRAVPAFFWSNNTTFKPTASDTVLTHDAITPTLLKLFDVT 312 >4QAX-A nrPDB Length = 513 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 52/132 (39%), Gaps = 21/132 (15%) Query: 240 YASKPFLGTSQR-GRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPE 298 +A+ +G S A+ +D+ +G++++ + D+ + + T+D+G + Sbjct: 401 FANPDMVGHSGMLEPTIKAIEAVDECLGEVVDKILDM----DGYAIITADHG-----NSD 451 Query: 299 QGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPP 358 Q ++ TT P + G + G + DL T L L + P Sbjct: 452 QVLTDDDQPMTTHTTNP----VPVIV-----TKEGVTLRETGRLGDLAPTLLDLLNVEQP 502 Query: 359 SDRAIDGLNLLP 370 D + G +L+ Sbjct: 503 ED--MTGESLIK 512 >5GZ5-A nrPDB Length = 830 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 53/327 (16%), Positives = 92/327 (28%), Gaps = 77/327 (23%) Query: 8 TRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGL 67 T W + S+A G Q P IL + D L + PN++++ G Sbjct: 94 TSWLKDQCASSSASQCPEGFDQSPLILFSM-DGFRAEYLETW---DTLMPNINKLKTCGT 149 Query: 68 ------------LFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVG 115 F N Y+ ++TG +G N + + G Sbjct: 150 HAKYMRAVYPTKTFVNHYT-----------IVTGLYAETHGIIDNNMYDVKLNQNFSLSG 198 Query: 116 GIPDSEQLLPELLKKAGYVSKIVGK--WHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNK 173 + G+ WH + LK W GS G Y Sbjct: 199 SNMRNAAWWG-------------GQPIWHTAS---YQGLKAATYFWPGSEVKINGSYPTI 242 Query: 174 ARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFF--LYWA 231 + Y + P + E L ++ P F LY Sbjct: 243 YK-------------VYNKSTPFEARV----------MEVLKWLDLPKAKRPDFSTLYIE 279 Query: 232 VDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGA 291 T + G+ +++ D ++G ++E L+ ++ + + +D+G Sbjct: 280 EPDTTGHKFGPVS-------GQVIKSLQMADRTLGMLMEGLKQRNLHNCVNLILLADHGM 332 Query: 292 ALISAPEQGGSNGPFLCGKQTTFEGGM 318 IS F +EG Sbjct: 333 EAISCNRLEYMTDYFNTVDFFMYEGAA 359 >5VEN-A nrPDB Length = 416 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 16/82 (19%), Positives = 38/82 (46%), Gaps = 9/82 (10%) Query: 210 LQEALDFIKRQARHHPFFLYWAVDA-THAPVYASKPFLGTSQRGRYGDAVREIDDSIGKI 268 + + +++ + + FLYW T V P +G+ + ++D +G + Sbjct: 153 VAKIIEWFTAKDPINLGFLYWEEPDDTGHDVGPDSPLMGS--------VISDVDHKLGYL 204 Query: 269 LELLQDLHVADNTFVFFTSDNG 290 +++L+ + +N + TSD+G Sbjct: 205 IKMLKRAKLWNNVNLIVTSDHG 226 >2W5W-A nrPDB Length = 375 Score = 39.1 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 31/143 (21%), Positives = 50/143 (34%), Gaps = 27/143 (18%) Query: 198 LKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDA 257 ++ G N A+ F+ + + FF+ + + G + Y Sbjct: 223 MEKGRGNFLSAATDLAIQFLSK--DNSAFFIM--------SEGSQIDWGGHANNASY--L 270 Query: 258 VREI---DDSIGKILELLQDLHVADNTFVFFTSDN--GAALISAPEQGGSNGPFLCGK-- 310 + EI DD+IG L + NT V TSD+ G ++A + +G Sbjct: 271 ISEINDFDDAIGTALAFAKKDG---NTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTE 327 Query: 311 -QTTFEGGMR----EPALAWWPG 328 TF G P A+ PG Sbjct: 328 IGPTFSTGGHSATLIPVFAYGPG 350 >5YLE-A nrPDB Length = 334 Score = 38.7 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 41/106 (38%), Gaps = 10/106 (9%) Query: 254 YGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTT 313 Y +A+ DD I + ++ LQ A + + + SD+G E G NG +L G Sbjct: 216 YDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHG-------ESLGENGVYLHGMPNA 268 Query: 314 FEGGMR--EPALAWWPGHVT-AGQVSHQLGSIMDLFTTSLALAGLT 356 F + PA W + + + + T L L +T Sbjct: 269 FAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVT 314 >5VPU-A nrPDB Length = 523 Score = 37.1 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 43/114 (37%), Gaps = 18/114 (15%) Query: 256 DAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFE 315 AV +D +G++ E + +A + T+D+G + G+ T Sbjct: 424 KAVEAVDTCLGRVYEAV----MAKKGHMLITADHG--------NVEQMQDYESGQVHTQH 471 Query: 316 GGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL 369 P + P T + G + D+ T L L + P++ + G NL+ Sbjct: 472 TTELVPFIYVGPTQAT----IAEGGVLADVAPTILNLMQIPVPAE--MQGRNLI 519 >6A83-A nrPDB Length = 394 Score = 35.2 bits (79), Expect = 0.067, Method: Composition-based stats. Identities = 60/354 (16%), Positives = 106/354 (29%), Gaps = 53/354 (14%) Query: 20 AGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEG---LLFPNFYSAN 76 A +P ++L++ + G + +YG P TP LD + +F N ++ Sbjct: 43 ANFKDESGNEPRTLVLVIGESTQRGRMSLYGYPRETTPELDALHKTDPNLTVFNNVVTSR 102 Query: 77 PLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSK 136 P YT + E + ++ L ++K+AGY + Sbjct: 103 P--------------------YTIEILQQALTFANEKNPDLYLTQPSLMNMMKQAGYKTF 142 Query: 137 IVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPI 196 + Q S Y N+ R D ++ + E Sbjct: 143 WI-------TNQQTMTARNTMLTVFSRQTDKQYYMNQQRTQSAREYDTNVLKPFQEVL-- 193 Query: 197 NLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGD 256 A I + IK + R+ + + H P Y + Sbjct: 194 ---NDPAPKKLIIVHLLGTHIKYKYRYPENQGKFDGNTDHVP--PGLNAEELESYNDYDN 248 Query: 257 AVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAP--EQGGSNGPFLCGKQTTF 314 A D + +++ + + N F+ + SD+G + P + G N T Sbjct: 249 ANLYNDHVVASLIKDFKAAN--PNGFLVYFSDHGEEVYDTPPHKTQGRNEDNPTRHMYT- 305 Query: 315 EGGMREPALAWWPGHVTA------GQVSHQLGSIMDLFTTSLALAGLTPPSDRA 362 P L W A Q + S+ +L T LAGL+ Sbjct: 306 -----IPFLLWTSEKWQATHPRDFSQDVDRKYSLAELIHTWSDLAGLSYDGYDP 354 >5VEM-A nrPDB Length = 416 Score = 35.2 bits (79), Expect = 0.070, Method: Composition-based stats. Identities = 24/154 (15%), Positives = 46/154 (29%), Gaps = 16/154 (10%) Query: 258 VREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGG 317 + +ID +G ++++L+ + + + TSD+G S + T + Sbjct: 194 ISDIDKKLGYLIQMLKKAKLWNTLNLIITSDHGMTQCSEERLIELDQYLDKDHYTLIDQS 253 Query: 318 MREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLN-LLPT----- 371 P A P +V L P + + P Sbjct: 254 ---PVAAILPKEGKFDEVYEALTHA---HPNLTVYKKEDVPERWHYKYNSRIQPIIAVAD 307 Query: 372 ----LLQGRLMDRPIFYYRGDTLMAATLGQHKAH 401 +LQ + D + + D +A AH Sbjct: 308 EGWHILQNKSDDFLLGNHGYDNALADMHPIFLAH 341 >2X6Q-A nrPDB Length = 416 Score = 35.2 bits (79), Expect = 0.077, Method: Composition-based stats. Identities = 13/60 (21%), Positives = 22/60 (36%), Gaps = 7/60 (11%) Query: 437 KLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVP-AQPQLNVCNWAVMN 495 K P ++ LS + E+ E L R ++ L QP+L+ +M Sbjct: 147 KSPWLW------RCHIDLSSPNREFWEFLRRFVEKYDRYIFHLPEYVQPELDRNKAVIMP 200 >5OLB-A nrPDB Length = 844 Score = 34.4 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 38/88 (43%), Gaps = 13/88 (14%) Query: 207 QIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYG----DAVREID 262 + + L ++ P +A Y+ +P + G +G + +REID Sbjct: 251 ERRILTILQWLSLPDNERP--SVYAF-------YSEQPDFSGHKYGPFGPEMTNPLREID 301 Query: 263 DSIGKILELLQDLHVADNTFVFFTSDNG 290 ++G++++ L+ L + V F D+G Sbjct: 302 KTVGQLMDGLKQLKLHRCVNVIFVGDHG 329 >5MHP-A nrPDB Length = 871 Score = 34.0 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 37/88 (42%), Gaps = 13/88 (14%) Query: 207 QIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYG----DAVREID 262 + + L ++ P +A Y+ +P + G +G + +REID Sbjct: 283 ERRILTILQWLTLPDHERP--SVYAF-------YSEQPDFSGHKYGPFGPEMTNPLREID 333 Query: 263 DSIGKILELLQDLHVADNTFVFFTSDNG 290 +G++++ L+ L + V F D+G Sbjct: 334 KIVGQLMDGLKQLKLHRCVNVIFVGDHG 361 >6EPD-M nrPDB Length = 442 Score = 33.3 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 33/146 (22%), Positives = 40/146 (27%), Gaps = 6/146 (4%) Query: 348 TSLALAGLTPPSDRAIDGLNLL--PTLLQGRLMDRPIFYYRGDTLMAATLGQHKA-HFWT 404 T L LAG DG L+ L IF D + KA Sbjct: 250 TFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREV 309 Query: 405 WTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFH--LGRDPGERFPLSFASAEYQ 462 E Q F P V + N D L+ L R P A A Sbjct: 310 QRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIM 369 Query: 463 EALSRITSVV-QQHQEALVPAQPQLN 487 + SR +V + E L N Sbjct: 370 QIHSRKMNVSPDVNYEELARCTDDFN 395 >5VHO-F nrPDB Length = 267 Score = 33.3 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 33/146 (22%), Positives = 40/146 (27%), Gaps = 6/146 (4%) Query: 348 TSLALAGLTPPSDRAIDGLNLL--PTLLQGRLMDRPIFYYRGDTLMAATLGQHKA-HFWT 404 T L LAG DG L+ L IF D + KA Sbjct: 82 TFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREV 141 Query: 405 WTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFH--LGRDPGERFPLSFASAEYQ 462 E Q F P V + N D L+ L R P A A Sbjct: 142 QRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIM 201 Query: 463 EALSRITSVV-QQHQEALVPAQPQLN 487 + SR +V + E L N Sbjct: 202 QIHSRKMNVSPDVNYEELARCTDDFN 227 >5VFP-F nrPDB Length = 396 Score = 33.3 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 33/146 (22%), Positives = 40/146 (27%), Gaps = 6/146 (4%) Query: 348 TSLALAGLTPPSDRAIDGLNLL--PTLLQGRLMDRPIFYYRGDTLMAATLGQHKA-HFWT 404 T L LAG DG L+ L IF D + KA Sbjct: 204 TFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREV 263 Query: 405 WTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFH--LGRDPGERFPLSFASAEYQ 462 E Q F P V + N D L+ L R P A A Sbjct: 264 QRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIM 323 Query: 463 EALSRITSVV-QQHQEALVPAQPQLN 487 + SR +V + E L N Sbjct: 324 QIHSRKMNVSPDVNYEELARCTDDFN 349 >5YKC-A nrPDB Length = 586 Score = 31.0 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 10/69 (14%), Positives = 22/69 (31%), Gaps = 2/69 (2%) Query: 438 LPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWA 497 + + +D + Y E L + S Q ++ + P+ + N + Sbjct: 115 PEWSYIVEKDRPSNGLCYPGTFNYYEELKHLMSSTNQFEK--IQIFPRSSWSNHDASSGV 172 Query: 498 PPGCEKLGK 506 C G+ Sbjct: 173 SSACPYNGR 181 >1CBY-A nrPDB Length = 259 Score = 30.6 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 4/57 (7%) Query: 438 LPLIFHLGRDPGERFPLSFA---SAEYQEALSRITSVVQQHQEALVPAQPQLNVCNW 491 LPL F + D ++ L F SA Y E + ++VQ + P NV N+ Sbjct: 187 LPLAFEVSVDVEKQKVLFFTIKDSARY-EVKMKALTLVQALHSSNAPIVDIFNVNNY 242 >6EHL-A nrPDB Length = 739 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 24/164 (14%), Positives = 47/164 (28%), Gaps = 5/164 (3%) Query: 167 FGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPF 226 P + +A P + + + + G +N T A + + Sbjct: 562 LTPINEEADPLDDADDETSSLPPLESDDEEQDRDGTSNRTPTVAPPA-PVYRDHSEKKEL 620 Query: 227 FLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFT 286 D H ++ T + + R I S G + + H+ + V F+ Sbjct: 621 PQDEQQDQDHTQEARNQDSDNTQSEHSFEEMYRHILRSQGP-FDAVLYYHMMKDEPVVFS 679 Query: 287 SDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPA---LAWWP 327 + +G P+L K+ E +WP Sbjct: 680 TSDGKEYTYPDSLEEEYPPWLTEKEAMNEENRFVTLDGQQFYWP 723 >6REQ-B nrPDB Length = 637 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 20/44 (45%) Query: 344 DLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRG 387 DL T+L+LAG P + + L +GR ++ + + Sbjct: 14 DLTPTTLSLAGDFPKATEEQWEREVEKVLNRGRPPEKQLTFAEC 57 >5Z6H-A nrPDB Length = 563 Score = 30.6 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 12/35 (34%) Query: 481 PAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIP 515 P Q N + C K C + PE+ P Sbjct: 520 PLQDGFGWSNGVTLKMLDRVCPKAKPCDSVPENQP 554 >3PLS-A nrPDB Length = 298 Score = 30.2 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 20/57 (35%), Gaps = 2/57 (3%) Query: 349 SLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTW 405 L P R ID +L L QGR + +P Y D+L +A Sbjct: 218 LWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPE--YCPDSLYQVMQQCWEADPAVR 272 >3IU6-A nrPDB Length = 147 Score = 29.8 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 13/94 (13%), Positives = 30/94 (31%), Gaps = 4/94 (4%) Query: 419 CPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEA 478 C +++ + + K PL F + R E +QE + + ++ Sbjct: 29 CYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDL-FQEHMFEVLERARRMNRT 87 Query: 479 LVPA-QPQLNVCNWAVMNWAPPGCEKLGKCLTPP 511 + + + + + K G+ L P Sbjct: 88 DSEIYEDAVELQQFFIKIRDELC--KNGEILLSP 119 >1UPS-A nrPDB Length = 420 Score = 29.8 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 8/78 (10%), Positives = 19/78 (24%) Query: 275 LHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQ 334 + + D+T +F S + + + + + Sbjct: 151 VGMQDDTNDWFNSKQTGEIDILETFFSKKDTWRIAAYGWNDPNFQTSWTISEDKVPSGDP 210 Query: 335 VSHQLGSIMDLFTTSLAL 352 S M+ T+L Sbjct: 211 TSEYHIYAMEWTPTALKF 228 >3KW7-A nrPDB Length = 502 Score = 29.4 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 13/81 (16%), Positives = 26/81 (32%), Gaps = 4/81 (4%) Query: 287 SDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQV----SHQLGSI 342 S N + T + G+R P + + P A + ++ Sbjct: 89 SGNSFLYDFTVPDQAGTFWYHSHLSTQYCDGLRGPLVVYDPSDPYASMYDVDDDTTVITL 148 Query: 343 MDLFTTSLALAGLTPPSDRAI 363 D + T+ L PP+ ++ Sbjct: 149 SDWYHTAAKLGPAFPPNADSV 169 >1PUJ-A nrPDB Length = 282 Score = 29.4 bits (64), Expect = 4.0, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 33/85 (38%), Gaps = 9/85 (10%) Query: 323 LAWWPGH-VTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRP 381 + W+PGH A + + ++D+ + A + S ++ +L+ + R Sbjct: 3 IQWFPGHMAKARREVTEKLKLIDIVYELVD-ARIPMSSRNP-----MIEDILKNKP--RI 54 Query: 382 IFYYRGDTLMAATLGQHKAHFWTWT 406 + + D AA Q K HF Sbjct: 55 MLLNKADKADAAVTQQWKEHFENQG 79 >1NTF-A nrPDB Length = 282 Score = 29.0 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 35/207 (16%), Positives = 64/207 (30%), Gaps = 8/207 (3%) Query: 50 GEPSRETPNLDRMAAEGLLF-PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAY 108 G S ETP++ +A +G F + P C + +LLT + + T Y Sbjct: 30 GLNSGETPDVIAVAVQGFGFQTDKPQQGPACVKNFQSLLTSKGYTKLKNTITETMGLTVY 89 Query: 109 TPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFG 168 ++ + + + + IV + + ++ DE S N + Sbjct: 90 CLEKHLDQNTLKNETIIVTVDDQKKSGGIVTSFTIYNKRFSFTTSRMSDEDVTSTNTKYA 149 Query: 169 -----PYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARH 223 Y K P+ ++ ++ R + I A D +K+ Sbjct: 150 YDTRLDYSKKDDPSDFLFWIGDLNVRVE--TNATHAKSLVDQNNIDGLMAFDQLKKAKEQ 207 Query: 224 HPFFLYWAVDATHAPVYASKPFLGTSQ 250 F + T P Y KP Sbjct: 208 KLFDGWTEPQVTFKPTYKFKPNTDEYD 234 >5NQ8-A nrPDB Length = 518 Score = 28.3 bits (61), Expect = 8.0, Method: Composition-based stats. Identities = 12/80 (15%), Positives = 23/80 (28%), Gaps = 4/80 (5%) Query: 287 SDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAG----QVSHQLGSI 342 S + + T + G+R P + + P A + ++ Sbjct: 110 SGHSFLYDFQVPDQAGTFWYHSHLSTQYCDGLRGPFVVYDPNDPQASLYDIDNDDTVITL 169 Query: 343 MDLFTTSLALAGLTPPSDRA 362 D + + L PP A Sbjct: 170 ADWYHVAAKLGPRFPPGSDA 189 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.119 0.316 Lambda K H 0.267 0.0365 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,960,306 Number of Sequences: 36641 Number of extensions: 742586 Number of successful extensions: 1985 Number of sequences better than 10.0: 64 Number of HSP's better than 10.0 without gapping: 63 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 1720 Number of HSP's gapped (non-prelim): 144 length of query: 522 length of database: 10,336,785 effective HSP length: 101 effective length of query: 421 effective length of database: 6,636,044 effective search space: 2793774524 effective search space used: 2793774524 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.3 bits)