BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P33261 (490 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4GQS-A nrPDB 967 0.0 5W0C-A nrPDB 884 0.0 2NNH-A nrPDB 776 0.0 1N6B-A nrPDB 754 0.0 3E6I-A nrPDB 603 e-173 4H1N-A nrPDB 516 e-147 2PG7-A nrPDB 506 e-143 5E0E-A nrPDB 497 e-141 5E58-A nrPDB 485 e-137 3IBD-A nrPDB 471 e-133 3TBG-A nrPDB 327 5e-90 3DL9-A nrPDB 290 1e-78 4R20-A nrPDB 253 1e-67 6B82-A nrPDB 241 6e-64 6IQ5-A nrPDB 227 8e-60 6DWN-A nrPDB 227 9e-60 4R1Z-A nrPDB 222 2e-58 5UYS-A nrPDB 204 8e-53 2HI4-A nrPDB 198 3e-51 5VBU-A nrPDB 186 2e-47 3QZ1-A nrPDB 171 8e-43 5YLW-A nrPDB 146 2e-35 6DA2-A nrPDB 120 1e-27 5VEU-A nrPDB 118 5e-27 3K9V-A nrPDB 101 8e-22 2VE3-A nrPDB 81 1e-15 6AYB-A nrPDB 80 2e-15 3MDV-A nrPDB 79 6e-15 6C94-A nrPDB 73 2e-13 3N9Z-A nrPDB 71 1e-12 3EL3-A nrPDB 71 1e-12 3S79-A nrPDB 71 1e-12 5FSA-A nrPDB 70 3e-12 3MZS-A nrPDB 69 7e-12 4KPA-A nrPDB 65 7e-11 3L4D-A nrPDB 65 9e-11 2WX2-A nrPDB 65 9e-11 5FOI-A nrPDB 63 3e-10 4ZGX-A nrPDB 62 5e-10 2Y5N-A nrPDB 61 1e-09 5JLC-A nrPDB 61 1e-09 5VWS-A nrPDB 60 3e-09 3TYW-A nrPDB 60 3e-09 4WMZ-A nrPDB 59 3e-09 3ABB-A nrPDB 59 5e-09 2VZM-A nrPDB 59 5e-09 3TKT-A nrPDB 57 1e-08 2X2N-A nrPDB 57 1e-08 6M7X-A nrPDB 57 1e-08 6M7L-A nrPDB 57 3e-08 6B11-A nrPDB 57 3e-08 2ZBZ-A nrPDB 57 3e-08 2Z36-A nrPDB 56 4e-08 6CR2-A nrPDB 55 5e-08 4OQR-A nrPDB 55 6e-08 2W0A-A nrPDB 55 8e-08 4OQS-A nrPDB 55 1e-07 4WPZ-A nrPDB 54 1e-07 6GMF-A nrPDB 54 1e-07 1CPT-A nrPDB 54 2e-07 3A1L-A nrPDB 53 3e-07 4RM4-A nrPDB 52 5e-07 3MGX-A nrPDB 52 5e-07 6FSH-A nrPDB 52 6e-07 4UBS-A nrPDB 52 6e-07 5EX6-C nrPDB 52 6e-07 3EJB-B nrPDB 52 7e-07 4TX3-A nrPDB 52 8e-07 4MM0-A nrPDB 51 9e-07 1Q5D-A nrPDB 51 1e-06 1Z8P-A nrPDB 51 1e-06 4GGV-A nrPDB 51 1e-06 6GK6-A nrPDB 51 1e-06 1WIY-A nrPDB 50 2e-06 6A7I-A nrPDB 50 2e-06 5YSW-A nrPDB 49 3e-06 6F0B-A nrPDB 49 5e-06 6A7J-A nrPDB 49 6e-06 5LIV-A nrPDB 48 8e-06 5NWS-A nrPDB 48 8e-06 5L1U-A nrPDB 48 1e-05 3SN5-A nrPDB 48 1e-05 5Y1I-A nrPDB 47 1e-05 3P3Z-A nrPDB 47 1e-05 6F88-A nrPDB 47 2e-05 5CJE-A nrPDB 47 2e-05 5XW2-A nrPDB 47 2e-05 2RFC-A nrPDB 47 3e-05 4YZR-A nrPDB 46 3e-05 3JUS-A nrPDB 45 5e-05 3WVS-A nrPDB 45 5e-05 1UE8-A nrPDB 45 8e-05 3R9C-A nrPDB 45 9e-05 5YHJ-A nrPDB 45 9e-05 3A50-A nrPDB 44 1e-04 5HH3-A nrPDB 44 2e-04 5IT1-A nrPDB 43 2e-04 2IJ7-A nrPDB 43 3e-04 3OO3-A nrPDB 43 3e-04 2XKR-A nrPDB 43 4e-04 1LG9-A nrPDB 42 5e-04 1GWI-A nrPDB 42 6e-04 4TRI-A nrPDB 42 7e-04 5Z9I-A nrPDB 42 8e-04 6FYJ-A nrPDB 41 0.001 2IAG-A nrPDB 41 0.001 4Z5P-A nrPDB 41 0.001 1ODO-A nrPDB 41 0.001 5EX8-A nrPDB 41 0.001 5L94-A nrPDB 41 0.001 6GII-A nrPDB 41 0.001 2FR7-A nrPDB 40 0.002 2X9P-A nrPDB 40 0.002 2WIO-A nrPDB 40 0.003 4YT3-A nrPDB 39 0.004 5HIW-A nrPDB 39 0.004 5DE9-A nrPDB 39 0.005 5GWE-A nrPDB 39 0.006 5XJN-A nrPDB 39 0.006 5XNT-A nrPDB 39 0.007 5M0P-A nrPDB 39 0.007 5LIE-A nrPDB 38 0.008 3ABA-A nrPDB 38 0.010 5FYF-A nrPDB 38 0.010 6G71-A nrPDB 37 0.013 4XE3-A nrPDB 37 0.013 4JBT-A nrPDB 37 0.014 2WM5-A nrPDB 37 0.016 6CVC-A nrPDB 37 0.017 5OFQ-A nrPDB 37 0.017 4DO1-A nrPDB 37 0.024 5DQN-A nrPDB 36 0.029 3AWQ-A nrPDB 36 0.035 2ZQJ-A nrPDB 35 0.056 3OFT-A nrPDB 35 0.057 2NZA-A nrPDB 35 0.10 5HDI-A nrPDB 34 0.13 3RWL-A nrPDB 34 0.15 4Z5Q-A nrPDB 33 0.19 3IVY-A nrPDB 33 0.24 1EHE-A nrPDB 33 0.33 4C9K-A nrPDB 32 0.56 3NV6-A nrPDB 32 0.67 1F4U-A nrPDB 32 0.69 2UUQ-A nrPDB 31 1.0 2QBO-A nrPDB 31 1.2 4DJD-D nrPDB 31 1.4 6DXS-A nrPDB 30 1.8 1PIO-A nrPDB 30 2.0 3IXQ-A nrPDB 30 2.1 3Q5X-A nrPDB 30 2.6 4CQI-A nrPDB 29 5.4 5A01-A nrPDB 28 7.4 >4GQS-A nrPDB Length = 477 Score = 967 bits (2500), Expect = 0.0, Method: Compositional matrix adjust. Identities = 467/470 (99%), Positives = 469/470 (99%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGY 80 + SSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGY Sbjct: 4 KTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGY 63 Query: 81 EVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS 140 EVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS Sbjct: 64 EVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS 123 Query: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 200 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK Sbjct: 124 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 183 Query: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNP 260 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNP Sbjct: 184 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNP 243 Query: 261 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 320 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT Sbjct: 244 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 303 Query: 321 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYL 380 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYL Sbjct: 304 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYL 363 Query: 381 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGL 440 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGL Sbjct: 364 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGL 423 Query: 441 ARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV 490 ARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP+ Sbjct: 424 ARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPI 473 >5W0C-A nrPDB Length = 477 Score = 884 bits (2283), Expect = 0.0, Method: Compositional matrix adjust. Identities = 427/470 (90%), Positives = 448/470 (95%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGY 80 + SSGRGKLPPGPTPLPVIGNILQI IKD+SKSLTNLSK+YGPVFTLYFGL+ +VVLHGY Sbjct: 4 KTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGY 63 Query: 81 EVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS 140 E VKEALIDLGEEFSGRG FPLAERANRGFGIVFSNGK+WKEIRRFSLMTLRNFGMGKRS Sbjct: 64 EAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 123 Query: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 200 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF KRFDYKDQQFLNLMEK Sbjct: 124 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 183 Query: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNP 260 LNENI+I+S+PWIQICNNF IIDYFPGTHNKLLKN+AFM+S ILEKVKEHQESMD+NNP Sbjct: 184 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNP 243 Query: 261 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 320 +DFIDCFL+KMEKEK NQ SEFTIE+L TA DL GAGTETTSTTLRYALLLLLKHPEVT Sbjct: 244 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT 303 Query: 321 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYL 380 AKVQEEIERV+GRNRSPCMQDR HMPYTDAVVHEVQRYIDL+PTSLPHAVTCD+KFRNYL Sbjct: 304 AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYL 363 Query: 381 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGL 440 IPKGTTIL SLTSVLHDNKEFPNPEMFDP HFLDEGGNFKKS YFMPFSAGKRICVGE L Sbjct: 364 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEAL 423 Query: 441 ARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV 490 A MELFLFLT ILQNFNLKSL+DPK+LDTTPVVNGFASVPPFYQLCFIP+ Sbjct: 424 AGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPI 473 >2NNH-A nrPDB Length = 476 Score = 776 bits (2004), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/472 (77%), Positives = 415/472 (87%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGPTPLP+IGN+LQID+KD+ KS TN SK+YGPVFT+YFG+ +VV H Sbjct: 1 MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 GYE VKEALID GEEFSGRG+ P+++R +G GI+ SNGKRWKEIRRFSL TLRNFGMGK Sbjct: 61 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 RSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCNVICS++FQKRFDYKDQ FL LM Sbjct: 121 RSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLM 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 ++ NEN RI+++PWIQ+CNNFP +ID FPGTHNK+LKN+A S I EKVKEHQ S+D+N Sbjct: 181 KRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVN 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NPRDFIDCFLIKME+EK NQ+SEF IENLV T ADL AGTETTSTTLRY LLLLLKHPE Sbjct: 241 NPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE 300 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 VTAKVQEEI+ V+GR+RSPCMQDR HMPYTDAVVHE+QRY DL+PT +PHAVT D KFRN Sbjct: 301 VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRN 360 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 YLIPKGTTI+ LTSVLHD+KEFPNP +FDP HFLD+ GNFKKS+YFMPFSAGKRIC GE Sbjct: 361 YLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGE 420 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV 490 GLARMELFLFLT ILQNFNLKS+ D K+L+TT V G S+PP YQ+CFIPV Sbjct: 421 GLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV 472 >1N6B-A nrPDB Length = 473 Score = 754 bits (1948), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/472 (74%), Positives = 412/472 (87%), Gaps = 3/472 (0%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGPTP P+IGNILQID KD+SKSLT S+ YGPVFT+Y G++ VVLH Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 GYE VKEAL+DLGEEF+GRG P+ E+ ++G GI FSN K WKE+RRFSLMTLRNFGMGK Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 RSIEDR+QEEARCLVEELRKT ASPCDPTFILGCAPCNVICS+IF RFDYKD++FL LM Sbjct: 121 RSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 E L+EN+ ++ TPW+Q+ NNFP ++DYFPG H LLKN ++++ I+EKVKEHQ+ +D+N Sbjct: 181 ESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NPRDFIDCFLIKME+E EFT+E+LVI +DL GAGTETTSTTLRY+LLLLLKHPE Sbjct: 241 NPRDFIDCFLIKMEQE---NNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPE 297 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 V A+VQEEIERV+GR+RSPCMQDR MPYTDAV+HE+QR+IDL+PT+LPHAVT DV+FRN Sbjct: 298 VAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 357 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 Y IPKGT I+TSLTSVLHD K FPNP++FDP HFLDE GNFKKS+YFMPFSAGKR+CVGE Sbjct: 358 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 417 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV 490 GLARMELFLFLT ILQNF L+SL++PKDLD T VVNGF SVPP YQLCFIP+ Sbjct: 418 GLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIPI 469 >3E6I-A nrPDB Length = 476 Score = 603 bits (1554), Expect = e-173, Method: Compositional matrix adjust. Identities = 273/471 (57%), Positives = 364/471 (77%), Gaps = 1/471 (0%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGP PLP+IGN+ Q+++K++ KS T L++ +GPVFTLY G +RMVV+H Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 GY+ VKEAL+D +EFSGRG P A A+R GI+F+NG WK+IRRFSL TLRN+GMGK Sbjct: 61 GYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 119 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 + E R+Q EA L+E LRKT+ P DPTF++GCAPCNVI I+F+K FDY D++FL LM Sbjct: 120 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 179 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 NEN ++STPW+Q+ NNFP+ + Y PG+H K++KN+A ++ + E+VKEH +S+D N Sbjct: 180 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 239 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 PRD DC L++MEKEK + + +T++ + +T ADL AGTETTSTTLRY LL+L+K+PE Sbjct: 240 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 299 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 + K+ EEI+RV+G +R P ++DR MPY DAVVHE+QR+I L+P++LPH T D FR Sbjct: 300 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 359 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S+YF PFS GKR+C GE Sbjct: 360 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 419 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 GLARMELFL L ILQ+FNLK L+DPKD+D +P+ GF +PP Y+LC IP Sbjct: 420 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 470 >4H1N-A nrPDB Length = 479 Score = 516 bits (1329), Expect = e-147, Method: Compositional matrix adjust. Identities = 241/470 (51%), Positives = 338/470 (71%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGP+PLPV+GN+LQ+D K + +S L + YG VFT+Y G +VVL Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 G + ++EAL+D E FSGRG + + +G+G++F+NG+RW+ +RRFSL T+R+FGMGK Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 RS+E+R+QEEARCLVEELRK+K + D T + N+ICSI+F KRFDYKD FL L+ Sbjct: 121 RSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLL 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 + ++ ++S+ Q+ F + YFPGTH ++ +NL + + I + V++H+ ++D + Sbjct: 181 DLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPS 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NPRDFID +L++MEK+K + SEF +NL++T L AGTETTSTTLRY LL+LK+P Sbjct: 241 NPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPH 300 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 VT +VQ+EIE+V+G +R P + DR MPYTDAV+HE+QR DLIP +PH VT D +FR Sbjct: 301 VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRG 360 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 Y+IPK T + L+S LHD + F P F+P HFLD G K++ FMPFS GKRIC+GE Sbjct: 361 YVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGE 420 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFI 488 G+AR ELFLF T ILQNF++ S + P+D+D TP +G +VPP YQ+ F+ Sbjct: 421 GIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFL 470 >2PG7-A nrPDB Length = 476 Score = 506 bits (1302), Expect = e-143, Method: Compositional matrix adjust. Identities = 242/471 (51%), Positives = 333/471 (70%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGPTPLP IGN LQ++ + + SL +S+ YGPVFT++ G R+VVL Sbjct: 1 MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 G++ V+EAL+D EEFSGRG + +G+G+VFSNG+R K++RRFS+ TLR+FG+GK Sbjct: 61 GHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 R IE+R+QEEA L++ LR T + DPTF L NVI SI+F RFDYKD++FL+L+ Sbjct: 121 RGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 + + ST Q+ F +++ + PG + + L +E I +KV+ +Q ++D N Sbjct: 181 RMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPN 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 +PRDFID FLI+M++E++N +EF ++NLV+T L GTET STTLRY LLL+KHPE Sbjct: 241 SPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPE 300 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 V AKV EEI+RV+G+NR P +DR MPY +AV+HE+QR+ D+IP SL V D KFR+ Sbjct: 301 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 360 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 + +PKGT + L SVL D F NP+ F+P+HFL+E G FKKS+ F+PFS GKR C GE Sbjct: 361 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGE 420 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 GLARMELFLF T ++QNF LKS PKD+D +P GFA++P Y + F+P Sbjct: 421 GLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLP 471 >5E0E-A nrPDB Length = 463 Score = 497 bits (1280), Expect = e-141, Method: Compositional matrix adjust. Identities = 233/448 (52%), Positives = 321/448 (71%) Query: 41 NILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHF 100 N+LQ+D S + + YG VFT++ G +V+L+G E ++EAL+D E FSGRG Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 101 PLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + E RG+G+VF+NG+RWK +RRFSL+T+R+FGMGKRS+E+R+QEEARCLVEE RK++ Sbjct: 74 AVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQ 133 Query: 161 ASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFP 220 +P DPTF+ C N+ICSI+F +RFDYKD QFL L+ ++ ++S+ Q+ F Sbjct: 134 GAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFS 193 Query: 221 TIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS 280 + YFPGTH ++ +NL + I + V++H+ ++D ++PRDFID +L++MEKEK NQ + Sbjct: 194 GFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 281 EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ 340 EF +NLVI+ L AGTET+STTLRY LL+LK+P V KVQ+EI++V+G +R P ++ Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 341 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400 DR MPYT+AV++E+QR+ DLIP +PH VT D FR YL+PK T + L+S LHD + Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 401 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKS 460 F P+ F+P HFLD G KKS FMPFS GKRIC+GEG+AR ELFLF T ILQNF+L S Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSS 433 Query: 461 LIDPKDLDTTPVVNGFASVPPFYQLCFI 488 + PKD+D +P +GF VP YQ+CF+ Sbjct: 434 PVAPKDIDLSPKESGFGKVPQTYQICFL 461 >5E58-A nrPDB Length = 493 Score = 485 bits (1248), Expect = e-137, Method: Compositional matrix adjust. Identities = 226/448 (50%), Positives = 313/448 (69%) Query: 41 NILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHF 100 N+LQ+D S + + YG VFT++ G +V+L+G E ++EAL+D E FSGRG Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 101 PLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + + +G++FSNG+RWK +RRFSL T+R+FGMGKRS+EDR+QEEA+CLVEEL+K++ Sbjct: 102 AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQ 161 Query: 161 ASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFP 220 +P DPTF+ C N+ICSI+F +R+DYKD+QFL L++ ++S+ Q+ F Sbjct: 162 GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 221 TIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS 280 + YFPG H ++ +NL + + + V++H+ ++D +NPRDFID +L++MEKEK NQ + Sbjct: 222 GFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 281 EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ 340 EF +NL+I+ L AGTETTSTTLRY LL+LK+P V KVQ+EI++V+G +R P ++ Sbjct: 282 EFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 341 Query: 341 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400 DR MPYTDAV+HE+QR+ DL P PH VT D FR YL+PK T + L+S LHD + Sbjct: 342 DRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 401 Query: 401 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKS 460 F P F+P HFLD G KKS FMPFS GKRIC+GEG+AR ELFLF T ILQNF++ S Sbjct: 402 FEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSS 461 Query: 461 LIDPKDLDTTPVVNGFASVPPFYQLCFI 488 + PKD+D +P +G VP YQ+ F+ Sbjct: 462 SVAPKDIDLSPKESGIGKVPQTYQISFL 489 >3IBD-A nrPDB Length = 476 Score = 471 bits (1213), Expect = e-133, Method: Compositional matrix adjust. Identities = 229/471 (48%), Positives = 327/471 (69%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGP PLP++GN+LQ+D + + KS + YG VFT++ G +V+L Sbjct: 1 MAKKTSSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 G E ++EAL+D E FSGRG + + RG+G++F+NG RWK +RRFS+ T+R+FGMGK Sbjct: 61 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 RS+E+R+QEEA+CL+EELRK+K + DPTF+ N+ICSI+F KRF Y+DQ+FL ++ Sbjct: 121 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 + ++S+ + Q+ F + +FPG H ++ KNL + + I V++H+E++D + Sbjct: 181 NLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 PRD ID +L+ MEKEK N SEF+ +NL + L AGTETTSTTLRY LL+LK+P Sbjct: 241 APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 300 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 V +V EIE+V+G +R P + DR MPYT+AV++E+QR+ DL+P +PH VT FR Sbjct: 301 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 360 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 Y+IPK T + L++ LHD F P+ F+P HFLD G KK+ F+PFS GKRIC+GE Sbjct: 361 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 420 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 G+AR ELFLF T ILQNF++ S + P+D+D TP G +PP YQ+ F+P Sbjct: 421 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 471 >3TBG-A nrPDB Length = 479 Score = 327 bits (839), Expect = 5e-90, Method: Compositional matrix adjust. Identities = 194/474 (40%), Positives = 282/474 (59%), Gaps = 7/474 (1%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGY 80 +++S +GKLPPGP PLP +GN+L +D ++ L + +G VF+L +VVL+G Sbjct: 3 KKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGL 62 Query: 81 EVVKEALIDLGEEFSGRGHFPLAE---RANRGFGIVFSN-GKRWKEIRRFSLMTLRNFGM 136 V+EAL+ GE+ + R P+ + R G+ + G W+E RRFS+ TLRN G+ Sbjct: 63 AAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGL 122 Query: 137 GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 196 GK+S+E V EEA CL P P +L A NVI S+ +RF+Y D +FL Sbjct: 123 GKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLR 182 Query: 197 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMD 256 L++ E ++ S ++ N P ++ + P K+L+ + + E + EH+ + D Sbjct: 183 LLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAFLTQLDELLTEHRMTWD 241 Query: 257 -INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315 PRD + FL +MEK K N +S F ENL I ADL AG TTSTTL + LLL++ Sbjct: 242 PAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMIL 301 Query: 316 HPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 375 HP+V +VQ+EI+ V+G+ R P M D+ HMPYT AV+HEVQR+ D++P + H + D++ Sbjct: 302 HPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIE 361 Query: 376 FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRIC 435 + + IPKGTT++T+L+SVL D + P F P HFLD G+F K F+PFSAG+R C Sbjct: 362 VQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRAC 421 Query: 436 VGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 +GE LARMELFLF T +LQ+F+ S+ + + V F P Y+LC +P Sbjct: 422 LGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVP 474 >3DL9-A nrPDB Length = 479 Score = 290 bits (741), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 150/402 (37%), Positives = 241/402 (59%), Gaps = 1/402 (0%) Query: 58 SKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSN- 116 S++YG +F+L G VVL+GY+VVKE L+ E F+ R PL + + G++ S Sbjct: 44 SQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRY 103 Query: 117 GKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN 176 G+ W + RR ++ + R FG G++S E ++ EE + + + K P D ++ A N Sbjct: 104 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 163 Query: 177 VICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKN 236 + IIF +RF Y+D F +++E +EN+ + ++ + + N FP I G H +L +N Sbjct: 164 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 223 Query: 237 LAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLG 296 A + + +++ + P+ F+D +L +M++ K + S F+ ENL+ + +L+ Sbjct: 224 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII 283 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQ 356 AGTETT+ LR+A+L + +P + +VQ+EI+ ++G N P D+ MPYT+AV+HEV Sbjct: 284 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 343 Query: 357 RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416 R+ +++P + HA + D R Y IPKGTT++T+L SV D K + +PE+F P FLD Sbjct: 344 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 403 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 G F K +PFS G+R C+GE LARME+FLF T +LQ F+L Sbjct: 404 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 445 >4R20-A nrPDB Length = 486 Score = 253 bits (646), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 142/413 (34%), Positives = 221/413 (53%), Gaps = 21/413 (5%) Query: 55 TNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGF-GIV 113 T LS YGP+F LY G +V+ +V+E L+ G EF+GR + +G I Sbjct: 46 TQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDIA 105 Query: 114 FSN-GKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC 172 F++ WK RR + FG G ++ VQE A L EEL+ + D + +L Sbjct: 106 FADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLMR 165 Query: 173 APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVST-------PWIQICNNFPTIIDY 225 A NVIC ++F + D + +++ + ++ ++ PW++I Sbjct: 166 AVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRI---------- 215 Query: 226 FPGTHNKLLKNLAFMESDIL-EKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTI 284 FP K LK + +L +K+ EH++S+ PRD +D LI ++ + T Sbjct: 216 FPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQR-GSGGADDITE 274 Query: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344 +++++TAA+ GAG ETTSTTL + + LL HP++ +VQ E++ VG +R PC+ DR H Sbjct: 275 DHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPH 334 Query: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404 +P DAV+ EV R + P +PH D + +PKGT +L ++ ++ HD K + P Sbjct: 335 LPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQP 394 Query: 405 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 457 E F+P FL+ G K + F+PF AG R+CVGE LAR+ELFLF++ LQ F+ Sbjct: 395 EQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFS 447 >6B82-A nrPDB Length = 509 Score = 241 bits (615), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 146/451 (32%), Positives = 240/451 (53%), Gaps = 35/451 (7%) Query: 30 PPGPTPLPVIGNILQIDIKDVSKS-----LTNLSKIYGPVFTLYFGLERMVVLHGYEVVK 84 PP LP+IG+++ + VS S +L K YG +++L G ++++++ + K Sbjct: 25 PPSLPSLPIIGSLMSL----VSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAK 80 Query: 85 EALIDLGEEFSGRGHFPLAERANR-GFGIVFSN-GKRWKEIRRFSLMTLRNFGMGKRSIE 142 E LI G+ F+GR + R G I F++ WK R+ L FG G SIE Sbjct: 81 EILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIE 140 Query: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLN 202 + EA + E L +++ S D L A NV+C++ F + D +F ++++ Sbjct: 141 KIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQ 200 Query: 203 ENIRIVST-------PWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQES 254 + V+ PW+QI FP ++L+ + +L+K +EH+ + Sbjct: 201 GIVDTVAKDSLVDIFPWLQI----------FPNKDLRILRQCISIRDKLLQKKYEEHKVT 250 Query: 255 MDINNPRDFIDCFLIKMEKEKQNQQSE----FTIENLVITAADLLGAGTETTSTTLRYAL 310 N RD +D L + N S T +++++T ++ GAG ETT+TTL++++ Sbjct: 251 YSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSI 310 Query: 311 LLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 370 L+ +P+V K+QEE++ +G+ R P + DRG++PY +A + EV R + P +PH Sbjct: 311 AYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVA 370 Query: 371 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK--KSNYFMPF 428 D Y + KGT ++ ++ S+ HD KE+ NPE+FDP FL+E G+ S ++PF Sbjct: 371 LQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPF 430 Query: 429 SAGKRICVGEGLARMELFLFLTFILQNFNLK 459 AG R+C+GE LA+MELFLFL +ILQ F L+ Sbjct: 431 GAGVRVCLGEALAKMELFLFLAWILQRFTLE 461 >6IQ5-A nrPDB Length = 463 Score = 227 bits (579), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 140/433 (32%), Positives = 220/433 (50%), Gaps = 35/433 (8%) Query: 53 SLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGI 112 S L++ YG VF + G +VVL+G + +AL+ G F+ R F + G + Sbjct: 6 SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGRSM 65 Query: 113 VFSN-GKRWKEIRRFSLMTLRNF----GMGKRSIEDRVQEEARCLVEELRKTKASPC--D 165 F + + WK RR + +RNF ++ +E V EAR LV L + A D Sbjct: 66 AFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLD 125 Query: 166 PTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVST-------PWIQICNN 218 P + A NV+ ++ F R+ + D +F L+ E R V PW+Q Sbjct: 126 PRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQ---- 181 Query: 219 FPTIIDYFPGTHNKLLKNLAFMESD----ILEKVKEHQESMDINN-PRDFIDCFLIKMEK 273 YFP + + + + IL+K H ES+ PRD +D F++ EK Sbjct: 182 ------YFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEK 235 Query: 274 EKQNQQ----SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 + + +EN+ T D+ GA +T ST L++ LLL ++P+V +VQ E+++ Sbjct: 236 KAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQ 295 Query: 330 VVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILT 389 VVGR+R PCM D+ ++PY A ++E R+ +P ++PHA T + Y IPK T + Sbjct: 296 VVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFV 355 Query: 390 SLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--SNYFMPFSAGKRICVGEGLARMELFL 447 + SV HD ++PNPE FDP FLD+ G K ++ M FS GKR C+GE L++M+LFL Sbjct: 356 NQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFL 415 Query: 448 FLTFILQNFNLKS 460 F++ + + ++ Sbjct: 416 FISILAHQCDFRA 428 >6DWN-A nrPDB Length = 491 Score = 227 bits (579), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 149/470 (31%), Positives = 247/470 (52%), Gaps = 24/470 (5%) Query: 21 RQSSGRG-KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHG 79 +++S +G K PPGP P+IG++L + K+ +L+ +S+ YG V + G +VVL G Sbjct: 3 KKTSSKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 61 Query: 80 YEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMG 137 + +++AL+ G++F GR + G + FS +G W RR + L++F + Sbjct: 62 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 121 Query: 138 KRS-------IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFQKRFD 188 +E+ V +EA L+ L++ A P +P + + NVIC+I F +R+D Sbjct: 122 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 181 Query: 189 YKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK- 247 + Q+ L+L+ N +V + +F I+ Y P K+L ++K Sbjct: 182 HNHQELLSLVNLNNNFGEVVGS---GNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKM 238 Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQ---NQQSEFTIENLVITAADLLGAGTETTST 304 VKEH ++ + + RD D LI+ +EKQ N + + E ++ DL GAG +T +T Sbjct: 239 VKEHYKTFEKGHIRDITDS-LIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 297 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364 + ++L+ L+ +P V K+QEE++ V+GR+R P + DR H+PY +A + E R+ +P Sbjct: 298 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 357 Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--S 422 ++PH+ T D + + IPKG + + + HD K + NP F P FL G K S Sbjct: 358 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 417 Query: 423 NYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472 + F GKR C+GE +AR E+FLFL +LQ + K +D TP+ Sbjct: 418 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPI 466 >4R1Z-A nrPDB Length = 439 Score = 222 bits (566), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 133/407 (32%), Positives = 215/407 (52%), Gaps = 26/407 (6%) Query: 69 FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR-GFGIVFSN-GKRWKEIRRF 126 G ++++++ + KE LI G+ F+GR + R G I F++ WK R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 127 SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKR 186 L FG G SIE + EA + E L +++ S D L A NV+C++ F Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 187 FDYKDQQFLNLMEKLNENIRIVST-------PWIQICNNFPTIIDYFPGTHNKLLKNLAF 239 + D +F ++++ + V+ PW+QI FP +L+ Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQI----------FPNKDLTILRQCIS 170 Query: 240 MESDILEK-VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSE----FTIENLVITAADL 294 + +L+K +EH+ + N RD +D L + N S T +++++T D+ Sbjct: 171 IRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDI 230 Query: 295 LGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHE 354 GAG ETT+T L++++ L+ +P+V K+QEE++ +G+ R P + DRG++PY +A + E Sbjct: 231 FGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIRE 290 Query: 355 VQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLD 414 V R + P +PH D Y + KGT ++ +L S+ HD KE+ NPE+FDP FL+ Sbjct: 291 VLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLN 350 Query: 415 EGGNFK--KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459 E G+ S ++PF AG R+C+GE LA+MELFLFL +ILQ F L+ Sbjct: 351 EEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLE 397 >5UYS-A nrPDB Length = 494 Score = 204 bits (519), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 135/453 (29%), Positives = 230/453 (50%), Gaps = 31/453 (6%) Query: 27 GKLPPGPTPLPVIGNILQIDIK-DVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKE 85 K P LP++G++ + + + L K YGP++++ G + V++ +++ KE Sbjct: 7 AKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKE 66 Query: 86 ALIDLGEEFSGRGHFPLAERA-NRGFGIVFSN-GKRWKEIRRFSLMTLRNFGMGKRSIED 143 LI G++FSGR + A N GI F++ G W+ RR ++ T F G + +E Sbjct: 67 VLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEK 126 Query: 144 RVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNE 203 + +E L + L D +F + A NVI I F + D + LN+++ NE Sbjct: 127 IICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-LNVIQNYNE 185 Query: 204 NI--------RIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKE-HQES 254 I + PW++I FP + LK+ + +D+L K+ E ++E Sbjct: 186 GIIDNLSKDSLVDLVPWLKI----------FPNKTLEKLKSHVKIRNDLLNKILENYKEK 235 Query: 255 MDINNPRDFIDCFL-IKMEKEKQN----QQSEFTIENLVITA-ADLLGAGTETTSTTLRY 308 ++ + +D + KM + N Q SE +N ++T D+ GAG ETT++ +++ Sbjct: 236 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 295 Query: 309 ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPH 368 L LL +P+V K+ EEI++ VG +R+P + DR + +A + EV R + P +PH Sbjct: 296 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 355 Query: 369 AVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN--FKKSNYFM 426 D + + KGT ++ +L ++ H+ KE+ P+ F P FL+ G S ++ Sbjct: 356 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 415 Query: 427 PFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459 PF AG R C+GE LAR ELFL + ++LQ F+L+ Sbjct: 416 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 448 >2HI4-A nrPDB Length = 495 Score = 198 bits (504), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 133/460 (28%), Positives = 224/460 (48%), Gaps = 20/460 (4%) Query: 28 KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 87 K PP P P++G++L + K+ +L+ +S+ YG V + G ++VL + +++AL Sbjct: 16 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 74 Query: 88 IDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMGKRS----- 140 + G++F GR + G + FS +G W RR + L F + Sbjct: 75 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 134 Query: 141 --IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 196 +E+ V +EA+ L+ L++ A P DP + + NVI ++ F + F + L+ Sbjct: 135 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 194 Query: 197 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESM 255 L++ +E + S+ + FP I+ Y P + K L+K V+EH + Sbjct: 195 LVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 251 Query: 256 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315 D N+ RD +K + + E +V D+ GAG +T +T + ++L+ L+ Sbjct: 252 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 311 Query: 316 HPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 375 PE+ K+Q+E++ V+GR R P + DR +PY +A + E R+ +P ++PH+ T D Sbjct: 312 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 371 Query: 376 FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG---NFKKSNYFMPFSAGK 432 + IPK + + V HD + + +P F P FL G N S M F GK Sbjct: 372 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 431 Query: 433 RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472 R C+GE LA+ E+FLFL +LQ S+ +D TP+ Sbjct: 432 RRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 470 >5VBU-A nrPDB Length = 476 Score = 186 bits (472), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 137/453 (30%), Positives = 224/453 (49%), Gaps = 37/453 (8%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGY 80 +++S +GKLPP + L + D+ L L++ +GP++ L+ GL+ +VVL+ Sbjct: 3 KKTSSKGKLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSK 56 Query: 81 EVVKEALIDLGEEFSGRGH---FPLAER--ANRGFGIVFSNGKRWKEIRRFSLMTLRNFG 135 ++EA++ +F+GR + L R + G K K++ R +L+ Sbjct: 57 RTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL------ 110 Query: 136 MGKR-SIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQF 194 +G R S+E V++ + E +R +P C++IC + F + KD Sbjct: 111 LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDD-- 166 Query: 195 LNLMEKLNENIRIVSTPW----IQICNNFPTIIDYFPGTHNKLLKNLAFMESDILE-KVK 249 NLM + I+ V W IQI + P + +FP + LK I+E +++ Sbjct: 167 -NLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLR 224 Query: 250 EHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLV-ITAADLLGAGTETTSTTLRY 308 +H+ES+ RD +D L + + + S +E V + A DLL GTETT+ TL + Sbjct: 225 QHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSW 284 Query: 309 ALLLLLKHPEVTAKVQEEIERVVGRNRSPC---MQDRGHMPYTDAVVHEVQRYIDLIPTS 365 A++ LL HPE+ ++QEE++ +G S +DR +P +A + EV R ++P + Sbjct: 285 AVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLA 344 Query: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425 LPH T Y IP+GT I+ +L D + P F P FL+ G N + Sbjct: 345 LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA---- 400 Query: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 + F G R+C+GE LAR+ELF+ LT +LQ F L Sbjct: 401 LAFGCGARVCLGEPLARLELFVVLTRLLQAFTL 433 >3QZ1-A nrPDB Length = 496 Score = 171 bits (432), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 126/434 (29%), Positives = 209/434 (48%), Gaps = 27/434 (6%) Query: 37 PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSG 96 P++ L + ++ L +L++ GPV+ L GL+ +VVL+ ++EA+I +F+G Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 97 RGHFP----LAERANR-GFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS-IEDRVQEEAR 150 R P +++R G K K++ R +L+ +G RS +E V + + Sbjct: 92 RPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALL------LGTRSSMEPWVDQLTQ 145 Query: 151 CLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVST 210 E +R +P C++IC + F + D F + ++ L + S Sbjct: 146 EFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDHWS- 204 Query: 211 PWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESMDINNPRDFIDCFLI 269 IQI + P + +FP LK ++EK ++ H+ESM RD D L Sbjct: 205 --IQILDMVP-FLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQ 261 Query: 270 KMEKEKQNQQSEFTIENLV-ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIE 328 + +++ + +E V ++ DL GTETT++TL +A+ LL HPE+ ++QEE++ Sbjct: 262 GVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELD 321 Query: 329 RVVGRNRSPC----MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 384 R +G S C +DR +P +A + EV R ++P +LPH T Y IP+G Sbjct: 322 RELGPGAS-CSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEG 380 Query: 385 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME 444 ++ +L D + P F P FL+ G N + F G R+C+GE LAR+E Sbjct: 381 MVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSA----LAFGCGARVCLGESLARLE 436 Query: 445 LFLFLTFILQNFNL 458 LF+ L +LQ F L Sbjct: 437 LFVVLARLLQAFTL 450 >5YLW-A nrPDB Length = 495 Score = 146 bits (368), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 125/483 (25%), Positives = 221/483 (45%), Gaps = 46/483 (9%) Query: 1 MDPF---VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNL 57 MD F L + + LS R R LPPGP P P++GN+LQ+ + + L Sbjct: 1 MDSFPLLAALFFIAATITFLSFRR----RRNLPPGPFPYPIVGNMLQLG-ANPHQVFAKL 55 Query: 58 SKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRG-----HFPLAERANRGFGI 112 SK YGP+ +++ G V++ E+ KE L G+ FSGR H ++ + GF Sbjct: 56 SKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLP 115 Query: 113 VFSNGKRWKEIRR------FSLMTLR-NFGMGKRSIEDRVQEEARCLVEELRKTKASPCD 165 V S W+++R+ FS ++ + G+ ++ ++ + +C D Sbjct: 116 VASE---WRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKC------SDSGRAVD 166 Query: 166 PTFILGCAPCNVICSIIFQKRF-DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIID 224 N++ + +F + ++ + + E + IV P + FP + Sbjct: 167 IREAAFITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVP--NFADYFPILRP 224 Query: 225 YFP-GTHNK----LLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQ 279 + P G + K LA +E + E+++ + + + DF++ + + Q Sbjct: 225 FDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDII------QA 278 Query: 280 SEFTIENLVIT--AADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSP 337 +EF ++ T DL G++T +T++ +A+ L+ +P+ A+++ E++ V G + Sbjct: 279 NEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIV 338 Query: 338 CMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD 397 +PY AV+ EV R P LP D + YLIPKGT IL + ++ D Sbjct: 339 DESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRD 398 Query: 398 NKEFPNPEMFDPRHFLDEGGNFKKSNY-FMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 + +PE FDP FLD +FK +Y +PF +G+R+C G LA L + ++ NF Sbjct: 399 PSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNF 458 Query: 457 NLK 459 + K Sbjct: 459 DWK 461 >6DA2-A nrPDB Length = 487 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 118/445 (26%), Positives = 186/445 (41%), Gaps = 33/445 (7%) Query: 31 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALI-D 89 PGPTPLP +GNIL K K YG V+ Y G + ++ + +++K L+ + Sbjct: 19 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 77 Query: 90 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 148 F+ R P I + + WK +R SL++ F GK + + + + Sbjct: 78 CYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRLR--SLLS-PTFTSGKLKEMVPIIAQY 132 Query: 149 ARCLVEELRKTKAS--PCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIR 206 LV LR+ + P + G +VI S F D + +E + +R Sbjct: 133 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 192 Query: 207 I-VSTPWIQICNNFPTIID--------YFP-GTHNKLLKNLAFMESDILEKVKEHQESMD 256 P+ FP +I FP N L K++ M+ LE ++H+ Sbjct: 193 FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHR---- 248 Query: 257 INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKH 316 DF+ + ++ + LV + + AG ETTS+ L + + L H Sbjct: 249 ----VDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 304 Query: 317 PEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC--DV 374 P+V K+QEEI+ V+ P M Y D VV+E R L P ++ C DV Sbjct: 305 PDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR---LFPIAMRLERVCKKDV 361 Query: 375 KFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRI 434 + IPKG ++ ++ D K + PE F P F + + + PF +G R Sbjct: 362 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 421 Query: 435 CVGEGLARMELFLFLTFILQNFNLK 459 C+G A M + L L +LQNF+ K Sbjct: 422 CIGMRFALMNMKLALIRVLQNFSFK 446 >5VEU-A nrPDB Length = 480 Score = 118 bits (296), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 123/450 (27%), Positives = 193/450 (42%), Gaps = 44/450 (9%) Query: 31 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALI-D 89 PGPTPLP++GN+L + + K T K YG ++ Y G ++ + +V++ L+ + Sbjct: 18 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 76 Query: 90 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 148 F+ R L I + + WK IR SL++ F GK + + + + Sbjct: 77 CYSVFTNRRS--LGPVGFMKSAISLAEDEEWKRIR--SLLS-PTFTSGKLKEMFPIIAQY 131 Query: 149 ARCLVEELRKT--KASPCDPTFILGCAPCNVICSIIF----------QKRFDYKDQQFL- 195 LV LR+ K P I G +VI F Q F ++FL Sbjct: 132 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 191 Query: 196 -NLMEKLNENIRIVS--TPWIQICNNFPTIIDYFP-GTHNKLLKNLAFMESDILEKVKEH 251 ++ L +I + TP + N + FP T N L K++ M+ L ++H Sbjct: 192 FGFLDPLFLSIILFPFLTPVFEALN-----VSLFPKDTINFLSKSVNRMKKSRLNDKQKH 246 Query: 252 QESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALL 311 + DF+ + ++ + L + + AG ETTS+ L + L Sbjct: 247 R--------LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 298 Query: 312 LLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVT 371 L HP+V K+Q+EI+ V+ P M Y D VV+E R L P ++ T Sbjct: 299 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFPVAIRLERT 355 Query: 372 C--DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFS 429 C DV+ IPKG+ ++ ++ HD K + PE F P F + + Y PF Sbjct: 356 CKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFG 414 Query: 430 AGKRICVGEGLARMELFLFLTFILQNFNLK 459 G R C+G A M + L L +LQNF+ K Sbjct: 415 TGPRNCIGMRFALMNMKLALIRVLQNFSFK 444 >3K9V-A nrPDB Length = 482 Score = 101 bits (251), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 111/453 (24%), Positives = 196/453 (43%), Gaps = 51/453 (11%) Query: 31 PGPTPLPVIGNILQI----DIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEA 86 PGPT P++G++L+I +K +L K YG +F + G V L G + EA Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 85 Query: 87 LIDLGEEFSGRGHF----PLAERANRGFGIVFSNGKRWKEIRR-FSLMTLRNFGMGKRSI 141 L R + N +G++ G+ W+ +R F ++ + K + Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 143 Query: 142 EDRVQEEARCLVE---ELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 + ++ E +E EL + D L IC ++++KRF L+ Sbjct: 144 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRF--------GLL 195 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV-KEHQESMD- 256 +K E + F T I T K++ + + KV + H + D Sbjct: 196 QKETEEEALT----------FITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDT 245 Query: 257 -INNPRDFIDCFLIKMEKEKQN-------QQSEFTIENLVITAADLLGAGTETTSTTLRY 308 + + ID L + ++ QQ + + L +L A ETT+ +L + Sbjct: 246 IFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMW 305 Query: 309 ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPH 368 L L ++P+ ++ +E++ V+ N++P +D +MPY A + E R +P + Sbjct: 306 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-R 364 Query: 369 AVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE-FPNPEMFDPRHFLDEGGNFKKSNYF-- 425 + Y +PKG T+LT T VL +++ F + F P +L + KK N F Sbjct: 365 TLDKPTVLGEYALPKG-TVLTLNTQVLGSSEDNFEDSHKFRPERWLQKE---KKINPFAH 420 Query: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 +PF GKR+C+G LA ++L L L +I+Q +++ Sbjct: 421 LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI 453 >2VE3-A nrPDB Length = 444 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 50/165 (30%), Positives = 84/165 (50%), Gaps = 3/165 (1%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 LL AG ET ++ L LLL +H ++ +V++E + + ++ + MPY D V+ Sbjct: 251 LLFAGHETLTSALSSFCLLLGQHSDIRERVRQE-QNKLQLSQELTAETLKKMPYLDQVLQ 309 Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413 EV R I + + D +F+ + PKG + ++ D +P+PE FDP F Sbjct: 310 EVLRLIPPVGGGF-RELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERFT 368 Query: 414 DEGGNFKKSNY-FMPFSAGKRICVGEGLARMELFLFLTFILQNFN 457 +G + +PF G R C+G+ AR+E+ LF T ++Q F+ Sbjct: 369 PDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFD 413 >6AYB-A nrPDB Length = 466 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 108/472 (22%), Positives = 203/472 (43%), Gaps = 42/472 (8%) Query: 19 IWRQSSGRGKLPPG-PTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 77 + +++S +GKLPP P +P +G+ + K+ + + + SK YG VFT + M L Sbjct: 1 MAKKTSSKGKLPPRVPNLIPYVGSFVSF-AKNPVQFIIDNSKKYGDVFTATILGKEMTFL 59 Query: 78 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRF--SLMTLRN 133 + +++ E S R + R G G+V+ + +R E +F S +T Sbjct: 60 NHPKILDTFFKATDNELSLRDVYRFM-RPVFGTGVVYDADSTERMMEQVKFVSSGLTTAR 118 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQ 193 F + ED + + + L E A I + C + + +Q Sbjct: 119 FRVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASRCLLGDEV----------RQ 168 Query: 194 FLNL--MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKE- 250 +L+ + KL +I +P + P +K K + + ++L+K +E Sbjct: 169 YLSEKNLGKLYHDIDDGISPLSFFYPSLPA------PKRDKARKAVGEIFQELLDKRREE 222 Query: 251 ---HQESMDINNPRDFIDCFLIKMEKEKQNQQSEFT-IENLVITAADLLGAGTETTSTTL 306 H E + + D +D L + K+ Q E T + + I A L AG T+S T Sbjct: 223 HKKHPERLLDESKMDVVDHLLTQKYKDGQ----ELTDVHRIGILIAGLF-AGQHTSSITS 277 Query: 307 RYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRY---IDLIP 363 + L+ ++ + +V KV++E E ++G ++ M Y +A + E R + +I Sbjct: 278 SWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIM 337 Query: 364 TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423 C+ Y+IPKG ++ S + + NP++FDP + + K Sbjct: 338 RMARKPRECE----QYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKY 393 Query: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNG 475 +PF AG+ C+GE A +++ ++ +L+ F+++ + D T +V G Sbjct: 394 GAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPDPSYTSLVVG 445 >3MDV-A nrPDB Length = 456 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 97/416 (23%), Positives = 179/416 (43%), Gaps = 32/416 (7%) Query: 56 NLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPL----AERANRGFG 111 + +K YGPV + + V++ E VK+ L+ + + L ER G G Sbjct: 18 DWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF-GQG 76 Query: 112 IVFS-NGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFIL 170 +V N +RW + RR + + S+ + E+A LVE L + KA P + Sbjct: 77 LVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNEKAEQLVEIL-EAKADGQTPVSMQ 133 Query: 171 GCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTH 230 + I+ + F + L + L++ ++++ I + T+ + PG Sbjct: 134 DMLTYTAM-DILAKAAFGMETSMLLGAQKPLSQAVKLMLEG---ITASRNTLAKFLPGKR 189 Query: 231 NKLLK---NLAFMESDILEKVKEHQESMDINN--PRDFIDCFLIKMEKEKQNQQSEFTIE 285 +L + ++ F+ + V+ +E++ P D + L + E+ Q E ++ Sbjct: 190 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL---KAEEGAQDDEGLLD 246 Query: 286 NLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHM 345 N V AG ET++ L + ++ L + PE+ A++Q E++ V+G R +D G + Sbjct: 247 NFVT----FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRL 302 Query: 346 PYTDAVVHEVQRYIDLIPTSLP--HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPN 403 Y V+ E R L P + + + +P T +L S + + F + Sbjct: 303 QYLSQVLKESLR---LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFED 359 Query: 404 PEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459 P F+P F G + YF PFS G R C+G+ A+ME+ + + +LQ + Sbjct: 360 PLTFNPDRF-GPGAPKPRFTYF-PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 413 >6C94-A nrPDB Length = 497 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 104/220 (47%), Gaps = 10/220 (4%) Query: 248 VKEHQESMDINNPR--DFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTT 305 +++ +E I N R DF+D L+ + E Q S+ + V T + G +TT++ Sbjct: 246 LQDEKEREKIQNRRHLDFLD-ILLDVRGESGVQLSDTDLRAEVDT---FMFEGHDTTTSG 301 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTS 365 + + L + +PE + +EE+ ++G S +D M Y + E R +P Sbjct: 302 ISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVP-Q 360 Query: 366 LPHAVTCDVKFRN-YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424 + ++ V F + +P G+ I + ++ ++ +P+PE+FDP F E + + Sbjct: 361 VYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYA 420 Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP 464 F+PFSAG R C+G+ A E+ + L F +DP Sbjct: 421 FIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFS--VDP 458 >3N9Z-A nrPDB Length = 487 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 51/186 (27%), Positives = 91/186 (48%), Gaps = 14/186 (7%) Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 S+ + E++ ++L G +TTS TL++ L + ++ KVQ+ + V R Sbjct: 269 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN----LKVQDMLRAEVLAARHQAQ 324 Query: 340 QDRGHM----PYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 D M P A + E R + I +L + D+ R+Y+IP T + ++ ++ Sbjct: 325 GDMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 383 Query: 396 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYF--MPFSAGKRICVGEGLARMELFLFLTFIL 453 + F +PE FDP +L + N YF + F G R C+G +A +E+ +FL +L Sbjct: 384 REPTFFFDPENFDPTRWLSKDKNI---TYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 440 Query: 454 QNFNLK 459 +NF ++ Sbjct: 441 ENFRVE 446 >3EL3-A nrPDB Length = 467 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/236 (23%), Positives = 101/236 (42%), Gaps = 11/236 (4%) Query: 231 NKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVIT 290 N L +L + +I+ + + + P D + L++ + + + E I + V+ Sbjct: 217 NDALADLHLLVDEIIAERRASGQ-----KPDDLLTA-LLEAKDDNGDPIGEQEIHDQVVA 270 Query: 291 AADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDA 350 +L G+ET ++T+ + L L HPE ++++E+E V G R +D + +T Sbjct: 271 ---ILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGN 326 Query: 351 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 410 V+ E R + L + + Y IP G I+ S ++ D K + + FDP Sbjct: 327 VIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPD 385 Query: 411 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466 +L E PFSAGKR C + + +L L + + + + D Sbjct: 386 RWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSND 441 >3S79-A nrPDB Length = 503 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 95/200 (47%), Gaps = 13/200 (6%) Query: 265 DCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 +C E ++ + T EN+ ++L A +T S +L + L L+ KHP V + Sbjct: 274 ECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAII 333 Query: 325 EEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 384 +EI+ V+G R + D + + ++E RY ++ + A+ DV Y + KG Sbjct: 334 KEIQTVIGE-RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKG 391 Query: 385 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS---NYFMPFSAGKRICVGEGLA 441 T I+ ++ +H + FP P F NF K+ YF PF G R C G+ +A Sbjct: 392 TNIILNIGR-MHRLEFFPKPNEFTLE-------NFAKNVPYRYFQPFGFGPRGCAGKYIA 443 Query: 442 RMELFLFLTFILQNFNLKSL 461 + + L +L+ F++K+L Sbjct: 444 MVMMKAILVTLLRRFHVKTL 463 >5FSA-A nrPDB Length = 490 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 114/250 (45%), Gaps = 32/250 (12%) Query: 240 MESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGT 299 + + ++++K +E DI+ RD ID LI + + ++ I NL+I +L G Sbjct: 211 ISATYMKEIKLRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLI---GILMGGQ 267 Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVV----GRNRSPCMQDRGHMPYTDAVVHEV 355 T+++T + LL L + P + + +E+ ++ G +D +P + + E Sbjct: 268 HTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKET 327 Query: 356 QRYIDLIPTSLPHAVTCDVKF--RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHF- 412 R + + S+ VT ++ NY++PKG +L S + F NPE FDP + Sbjct: 328 LR-MHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWD 386 Query: 413 ----------------LDEG-GNFKK--SNYFMPFSAGKRICVGEGLARMELFLFLTFIL 453 +D G G K S+ ++PF G+ C+GE A ++L LT + Sbjct: 387 TAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV 446 Query: 454 QNFNLKSLID 463 +NL+ ID Sbjct: 447 --YNLRWTID 454 >3MZS-A nrPDB Length = 486 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 46/176 (26%), Positives = 84/176 (47%), Gaps = 2/176 (1%) Query: 284 IENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRG 343 +E++ ++L G TTS TL++ L + + V ++EE+ + + Sbjct: 274 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQ 333 Query: 344 HMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPN 403 +P A + E R + I +L D+ ++YLIP T + ++ ++ D F + Sbjct: 334 MVPLLKASIKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSS 392 Query: 404 PEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459 P+ FDP +L + + + F G R CVG +A +E+ LFL IL+NF ++ Sbjct: 393 PDKFDPTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 447 >4KPA-A nrPDB Length = 494 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 54/178 (30%), Positives = 80/178 (44%), Gaps = 6/178 (3%) Query: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344 EN+ L AG ETTS L +AL L+K+P V K EE RV+ + P + Sbjct: 276 ENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVL-VDPVPSYKQVKQ 334 Query: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF--P 402 + Y V++E R P +A V Y + KG ++ L LH +K Sbjct: 335 LKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMV-LIPQLHRDKTIWGD 393 Query: 403 NPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKS 460 + E F P F E + + F PF G+R C+G+ A E L L +L++F+ + Sbjct: 394 DVEEFRPERF--ENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFED 449 >3L4D-A nrPDB Length = 453 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 106/457 (23%), Positives = 185/457 (40%), Gaps = 57/457 (12%) Query: 26 RGKLPP---GPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEV 82 +GKLPP G TP +G+I+Q KD + K YG +FT+ R+ V+ Sbjct: 1 KGKLPPVVHGTTPF--VGHIIQFG-KDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQ 57 Query: 83 VKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG-KRWKEIRRF--SLMTLRNFGMGKR 139 + E S R + G G+ ++ R +E F +T+ F Sbjct: 58 HSKFFTPRNEILSPREVYSFMVPVF-GEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAP 116 Query: 140 SIEDRVQE--EARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF----QKRFDYKDQQ 193 SI+ V++ +A +E C I N C +F +KR D + Q Sbjct: 117 SIQHEVRKFMKANWNKDEGEINILDDCSAMII------NTACQCLFGEDLRKRLDAR--Q 168 Query: 194 FLNLMEKLNENI--RIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV--- 248 F L+ K+ + V PWI P + ++ DIL ++ Sbjct: 169 FAQLLAKMESCLIPAAVFLPWIL----------KLPLPQSYRCRDARAELQDILSEIIIA 218 Query: 249 KEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRY 308 +E +E+ N D + L + ++ + S+ + +++ A + AG T++ T + Sbjct: 219 REKEEAQKDTNTSDLLAGLLGAVYRDG-TRMSQHEVCGMIVAA---MFAGQHTSTITTTW 274 Query: 309 ALLLLL--KHPEVTAKVQEEIERVVGR-NRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTS 365 +LL L+ ++ AK+ +EI+ + N M++ MP+ + E R D Sbjct: 275 SLLHLMDPRNKRHLAKLHQEIDEFPAQLNYDNVMEE---MPFAEQCARESIRR-DPPLVM 330 Query: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK-KSNY 424 L V V+ Y++P+G I S D + FPNP ++P N K Sbjct: 331 LMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPER------NMKLVDGA 384 Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSL 461 F F AG C+GE +++ L +L++++ + L Sbjct: 385 FCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELL 421 >2WX2-A nrPDB Length = 473 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 100/218 (45%), Gaps = 15/218 (6%) Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 +E +E+ NN D + L+K + S + +++ A + AG T++ T Sbjct: 232 AREKEEASKDNNTSDLLGG-LLKAVYRDGTRMSLHEVCGMIVAA---MFAGQHTSTITTS 287 Query: 308 YALLLLL--KHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTS 365 +++L L+ K+ + K+ +EI+ + + D MP+ + V E R D Sbjct: 288 WSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRR-DPPLLM 344 Query: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425 + V +VK +Y++PKG I S HD + FPNP ++DP DE K F Sbjct: 345 VMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPER--DE----KVDGAF 398 Query: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID 463 + F AG C+G+ A +++ L + ++ + L D Sbjct: 399 IGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRD 436 >5FOI-A nrPDB Length = 408 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/185 (27%), Positives = 82/185 (44%), Gaps = 28/185 (15%) Query: 265 DCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 D L+ ++ + E T + LV A LL AG ET++ + ++L LL+HPE A+++ Sbjct: 215 DTGLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELR 274 Query: 325 EEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 384 E+ E MP V E+ RY I L A T D+ ++ I G Sbjct: 275 EQPEL---------------MPN---AVDELLRYHS-IADGLRRAATADIVLGDHTIRAG 315 Query: 385 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME 444 ++ L+S HD F FD + + + + F G C+G+ LAR+E Sbjct: 316 DGLIILLSSANHDGNTFGAEATFD---------IHRPARHHVAFGYGPHQCLGQNLARLE 366 Query: 445 LFLFL 449 + + L Sbjct: 367 MEVTL 371 >4ZGX-A nrPDB Length = 489 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 42/161 (26%), Positives = 76/161 (47%), Gaps = 6/161 (3%) Query: 279 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 338 ++E ++E + + +L +TT+ L L L ++P+V +++E Sbjct: 273 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 332 Query: 339 MQDRGHMPYTDAVVHEVQRYIDLIPTSL--PHAVTCDVKFRNYLIPKGTTILTSLTSVLH 396 + +P A + E R L P L V+ D+ +NY IP GT + L S+ Sbjct: 333 QKATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGR 389 Query: 397 DNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437 + FP PE ++P+ +LD G+ + ++ +PF G R C+G Sbjct: 390 NAALFPRPERYNPQRWLDIRGSGRNFHH-VPFGFGMRQCLG 429 >2Y5N-A nrPDB Length = 417 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 72/324 (22%), Positives = 127/324 (39%), Gaps = 72/324 (22%) Query: 140 SIEDRVQEEARCLVEELRKTKASPCDPTFILGCA-PCNVICSIIF-----QKRFDYKDQQ 193 S+ R +E A LV+++ T P D + P VIC ++ RF Sbjct: 129 SLRPRAREIAHELVDQMAAT-GQPADLVAMFARQLPVRVICELLGVPSADHDRFTRWSGA 187 Query: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE 253 FL+ E E ++ + + A+M D++++ + Sbjct: 188 FLSTAEVTAEEMQEAAE------------------------QAYAYM-GDLIDRRR---- 218 Query: 254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313 P D + L++ ++QQ + + L+ A LL AG E+T+T + + LL Sbjct: 219 ----KEPTDDLVSALVQ----ARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLL 270 Query: 314 LKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL-IPTSLPHAVTC 372 + PE+ ++ + E + + V E+ R++ L + T+ P Sbjct: 271 MTRPELRRQLLDRPELI------------------PSAVEELTRWVPLGVGTAFPRYAVE 312 Query: 373 DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK 432 DV R I G +L S + D +FP+ + D +D + N + F G Sbjct: 313 DVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRID----VD-----RTPNQHLGFGHGV 363 Query: 433 RICVGEGLARMELFLFLTFILQNF 456 C+G LAR+EL + L +LQ Sbjct: 364 HHCLGAPLARVELQVALEVLLQRL 387 >5JLC-A nrPDB Length = 515 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/244 (25%), Positives = 108/244 (44%), Gaps = 28/244 (11%) Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 +KE +E DI N RD ID + + + ++ I NL+I +L G T++ T Sbjct: 251 IKERREKNDIQN-RDLIDELMKNSTYKDGTKMTDQEIANLLI---GVLMGGQHTSAATSA 306 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRN-RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSL 366 + LL L + P+V ++ +E RV+ + + D +MP + ++ E R + SL Sbjct: 307 WCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPL-HSL 365 Query: 367 PHAVTCDVKFRN--YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHF------------ 412 V DV N Y++P+ +L S + FP P F+ + Sbjct: 366 FRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGG 425 Query: 413 --LDEG-GNFKK--SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL 467 +D G G K S+ ++PF G+ C+GE A +L + ++ ++ + P + Sbjct: 426 DEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRY---PTEG 482 Query: 468 DTTP 471 +T P Sbjct: 483 ETVP 486 >5VWS-A nrPDB Length = 393 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/232 (24%), Positives = 94/232 (40%), Gaps = 45/232 (19%) Query: 232 KLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITA 291 +L + +A +++ + ++EH S +PRD + L++ E E + +E +V TA Sbjct: 173 ELARTVAAAMTEMNDYLREHCRSRR-THPRDDLLTRLVQAEVEGKR----LDLEEVVNTA 227 Query: 292 ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVG------RNRSPCMQDRGHM 345 + LL AG TT+ + +L L HPE V+ + + R RSP +Q Sbjct: 228 SLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRADPSLIPAALEESLRLRSPFLQ----- 282 Query: 346 PYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPE 405 T DV IP ++ + S HD++ FP+PE Sbjct: 283 --------------------AGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPE 322 Query: 406 MFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 457 FD +++ + F G C+G L R+E + L +L F Sbjct: 323 RFD---------LHRQTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFT 365 >3TYW-A nrPDB Length = 417 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 82/185 (44%), Gaps = 29/185 (15%) Query: 283 TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR 342 T E L+ T + AG ETT++ + + LLLL PE+ A+++ +D Sbjct: 235 TTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELR---------------KDP 279 Query: 343 GHMPYTDAVVHEVQRYIDLIPTSLPHAVTC-DVKFRNYLIPKGTTILTSLTSVLHDNKEF 401 MP A V E+ R + + S+P V D++ +P ++ L HD ++F Sbjct: 280 DLMP---AAVDELLRVLS-VADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQF 335 Query: 402 PNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSL 461 +PE D + N+ + F G CVG+ LAR+EL + L +L+ L Sbjct: 336 DDPERVD---------FHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRL 386 Query: 462 IDPKD 466 +D Sbjct: 387 AGERD 391 >4WMZ-A nrPDB Length = 539 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 101/228 (44%), Gaps = 24/228 (10%) Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 +KE +++ DI + RD ID + + + ++ I NL+I +L G T++ T Sbjct: 269 IKERRKNNDIQD-RDLIDSLMKNSTYKDGVKMTDQEIANLLI---GVLMGGQHTSAATSA 324 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR-GHMPYTDAVVHEVQRYIDLIPTSL 366 + LL L + P+V ++ EE RV+ + D MP + + E R + SL Sbjct: 325 WILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPL-HSL 383 Query: 367 PHAVTCDVKFRN--YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHF------------ 412 V D+ N Y+IP G +L S ++ FPN F+ + Sbjct: 384 FRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGE 443 Query: 413 -LDEG-GNFKK--SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 +D G G K S+ ++PF G+ C+GE A +L + ++ ++ Sbjct: 444 EVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTL 491 >3ABB-A nrPDB Length = 408 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 88/208 (42%), Gaps = 30/208 (14%) Query: 275 KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRN 334 +Q ++ + + +V+ A LL AG ETT + L L++HPE Q ++ Sbjct: 221 RQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPE-----QIDV------- 268 Query: 335 RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSV 394 ++D G VV E+ R+ + + D++ I G +L S+T + Sbjct: 269 ---LLRDPG---AVSGVVEELLRFTS-VSDHIVRMAKEDIEVGGATIKAGDAVLVSITLM 321 Query: 395 LHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQ 454 D K + NP++FD R + + + + F G C+G+ LAR EL + L + Sbjct: 322 NRDAKAYENPDIFDAR---------RNARHHVGFGHGIHQCLGQNLARAELEIALGGLFA 372 Query: 455 NFNLKSLIDPKDLDTTPVVNGFASVPPF 482 L P LD P+ G + P Sbjct: 373 RIPGLRLAVP--LDEVPIKAGHDAQGPI 398 >2VZM-A nrPDB Length = 436 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 84/217 (38%), Gaps = 30/217 (13%) Query: 267 FLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEE 326 L + + S T E L+ A LL AG ETT + + LL HP+ A + Sbjct: 233 LLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAAL--- 289 Query: 327 IERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTT 386 R M D V E+ RY + ++ V +IP G T Sbjct: 290 ---------------RADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDT 334 Query: 387 ILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELF 446 +L L + FP+P FD R D G+ F G C+G LAR+E Sbjct: 335 VLVVLADAHRTPERFPDPHRFDIRR--DTAGHLA-------FGHGIHFCIGAPLARLEAR 385 Query: 447 LFLTFILQNF-NLKSLIDPKDL--DTTPVVNGFASVP 480 + + +L+ +L + P +L P++ G ++P Sbjct: 386 IAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALP 422 >3TKT-A nrPDB Length = 450 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 96/223 (43%), Gaps = 34/223 (15%) Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NP D + + + + T +ITA+ AG +TTS + A L L + P+ Sbjct: 255 NPTDDVATVIANAVVDGEPMSDRDTAGYYIITAS----AGHDTTSASSAGAALALARDPD 310 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 + A+V+ DR +P +V E R+ + + A T D + Sbjct: 311 LFARVK---------------ADRNLLP---GIVEEAIRWTTPVQHFMRTAAT-DTELCG 351 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 I G ++ + + HD +FP P FDP + +N + F AG C+G Sbjct: 352 QKIAAGDWLMLNYVAANHDPAQFPEPRKFDPT---------RPANRHLAFGAGSHQCLGL 402 Query: 439 GLARMELFLFLTFILQNFNLKSLI-DPKDLDTTPVVNGFASVP 480 LAR+E+ + L +L + L +PK +++T V GF S+P Sbjct: 403 HLARLEMRVLLDVLLDRVDSLELAGEPKRVNST-FVGGFKSLP 444 >2X2N-A nrPDB Length = 475 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 50/172 (29%), Positives = 75/172 (43%), Gaps = 17/172 (9%) Query: 297 AGTETTSTTLRYALLLLL-----KHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAV 351 AG T+S T +++L L+ KH E K EE + N M + MP+ + Sbjct: 277 AGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNN--VMDE---MPFAERC 331 Query: 352 VHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRH 411 E R D L V DVK +Y++PKG I S HD + FP P +DP Sbjct: 332 ARESIRR-DPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPER 390 Query: 412 FLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID 463 DE K F+ F AG C+G+ +++ L ++++ + L D Sbjct: 391 --DE----KVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRD 436 >6M7X-A nrPDB Length = 484 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 41/160 (25%), Positives = 71/160 (44%), Gaps = 6/160 (3%) Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 +E + + + + +L +TT L L L ++P V +++E Sbjct: 274 AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ 333 Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSL--PHAVTCDVKFRNYLIPKGTTILTSLTSVLHD 397 + +P A + E R L P L + D+ +NY IP GT + L S+ + Sbjct: 334 KATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 390 Query: 398 NKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437 FP PE ++P+ +LD G+ ++ Y +PF G R C+G Sbjct: 391 PALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLG 429 >6M7L-A nrPDB Length = 404 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 84/197 (42%), Gaps = 31/197 (15%) Query: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335 ++ ++ + E L A ++ + E T + L LLLL+HPE A ++E E Sbjct: 223 RDHGADISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPEQFALLRERPE------- 275 Query: 336 SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 + V E+ RY+ + P T DV+ +I KG + SL + Sbjct: 276 -----------LGEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAA- 323 Query: 396 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN 455 N+ P + FD +K + + F G C+G LARMEL + T ++ Sbjct: 324 --NRADPALDGFD---------ITRKESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSR 372 Query: 456 F-NLKSLIDPKDLDTTP 471 F +L++ + +++ P Sbjct: 373 FPSLRTAVPAEEIRFRP 389 >6B11-A nrPDB Length = 440 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/181 (24%), Positives = 78/181 (43%), Gaps = 28/181 (15%) Query: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335 Q + + +++ A LL AG ETT++ + ++L+LL+HP ++ Sbjct: 258 QARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTAWREL------------ 305 Query: 336 SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 + G +P V E+ RY+ I L + T D++ + I G ++ L + Sbjct: 306 ---TVNPGLLP---GAVDELLRYLS-IADGLRRSATADIEIDGHTIRAGDGLVFLLAAAN 358 Query: 396 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN 455 D F PE FD + + + F G C+G+ LARMEL + L +L+ Sbjct: 359 RDEAVFSEPEAFD---------IHRSARRHVAFGYGPHQCLGQNLARMELEVALGAVLER 409 Query: 456 F 456 Sbjct: 410 L 410 >2ZBZ-A nrPDB Length = 412 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 75/178 (42%), Gaps = 27/178 (15%) Query: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335 Q E E L+ TA LL AG ETT++ +++ LL HPE A ++ Sbjct: 223 QLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALR----------- 271 Query: 336 SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 DR +P V E+ RY+ + + T D++ LI G ++ + Sbjct: 272 ----ADRSLVP---GAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIAN 324 Query: 396 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFIL 453 D + +P+ D + + + + F G C+G+ LAR+EL + L ++ Sbjct: 325 RDGTVYEDPDALD---------IHRSARHHLAFGFGVHQCLGQNLARLELEVILNALM 373 >2Z36-A nrPDB Length = 413 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 50/196 (25%), Positives = 74/196 (37%), Gaps = 38/196 (19%) Query: 261 RDFIDCFLIKMEKE-----------KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYA 309 R +ID + + E E +Q Q+ LV A LL AG ETT+ + Sbjct: 198 RAYIDDLITRKESEPGDDLFSRQIARQRQEGTLDHAGLVSLAFLLLTAGHETTANMISLG 257 Query: 310 LLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHA 369 ++ LL HPE V+ R T V E+ RY + Sbjct: 258 VVGLLSHPEQLTVVKANPGR------------------TPMAVEELLRYFTIADGVTSRL 299 Query: 370 VTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFS 429 T DV+ I G ++ S+ S D F +P + D + + + + F Sbjct: 300 ATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVE---------RGARHHLAFG 350 Query: 430 AGKRICVGEGLARMEL 445 G C+G+ LARMEL Sbjct: 351 FGPHQCLGQNLARMEL 366 >6CR2-A nrPDB Length = 477 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 47/189 (24%), Positives = 86/189 (45%), Gaps = 24/189 (12%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR-GHMPYTDAVV 352 LL AG ++S+T + +L L P++ ++ +E RV+G + P D + V+ Sbjct: 258 LLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVI 317 Query: 353 HEVQRY---IDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDP 409 E R I I ++ + + D +Y+IP +L+S + FPNP ++P Sbjct: 318 KETLRLHAPIHSIIRAVKNPMAVDGT--SYVIPTSHNVLSSPGVTARSEEHFPNPLEWNP 375 Query: 410 RHFLDE-----GGNFKKSNY------------FMPFSAGKRICVGEGLARMELFLFLTFI 452 H DE + +K +Y ++PF AG+ C+GE A ++L + Sbjct: 376 -HRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVL 434 Query: 453 LQNFNLKSL 461 ++ F ++L Sbjct: 435 VRLFRFRNL 443 >4OQR-A nrPDB Length = 457 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/178 (29%), Positives = 76/178 (42%), Gaps = 32/178 (17%) Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 ++ T E L A LL AG ETT+ L LL+HPE A + SP Sbjct: 262 TDLTDEELTNIALILLVAGHETTANMLGLGTFALLQHPEQIANLD-----------SP-- 308 Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSLPH-AVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 DA V E+ RY+ ++ P+ A DV+ +I KG T+ L +V D Sbjct: 309 ---------DA-VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDP 358 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 K F P++ LD K + F G C+G+ LAR+E+ + T + F Sbjct: 359 KVFDEPDILQ----LDRVDARKHAA----FGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >2W0A-A nrPDB Length = 455 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 92/208 (44%), Gaps = 9/208 (4%) Query: 261 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 320 RD +D LI ++ E + F+ + + ++ AG T+S T + L+ L++H + Sbjct: 223 RDMLDV-LIAVKAETGTPR--FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAY 279 Query: 321 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIP--TSLPHAVTCDVKFRN 378 A V +E++ + G RS +P + V+ E R L P L + + + Sbjct: 280 AAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLR---LHPPLIILMRVAKGEFEVQG 336 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDP-RHFLDEGGNFKKSNYFMPFSAGKRICVG 437 + I +G + S ++FP+P F P R+ + ++PF AG+ CVG Sbjct: 337 HRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVG 396 Query: 438 EGLARMELFLFLTFILQNFNLKSLIDPK 465 A M++ + +L+ + + P+ Sbjct: 397 AAFAIMQIKAIFSVLLREYEFEMAQPPE 424 >4OQS-A nrPDB Length = 433 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/178 (29%), Positives = 76/178 (42%), Gaps = 32/178 (17%) Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 ++ T E L A LL AG ETT+ L LL+HPE A + SP Sbjct: 223 TDLTDEELTNIALLLLVAGHETTANMLGLGTFALLQHPEQIAALD-----------SP-- 269 Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSLPH-AVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 DA V E+ RY+ ++ P+ A DV+ +I KG T+ L +V D Sbjct: 270 ---------DA-VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDP 319 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 K F P++ LD K + F G C+G+ LAR+E+ + T + F Sbjct: 320 KVFDEPDILQ----LDRVDARKHAA----FGGGIHQCLGQQLARVEMRIGFTRLFARF 369 >4WPZ-A nrPDB Length = 397 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 99/228 (43%), Gaps = 37/228 (16%) Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NP D + LI + + S T ++ + +L AG ETT+ + L+ LL +PE Sbjct: 198 NPADDLISELIAI----SDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPE 253 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTS--LPHAVTCDVKF 376 K+++ +R +P V E+ R++ L T +P T +V+ Sbjct: 254 ELDKLRD---------------NREAIPKA---VDELLRFVPLTTTGGIIPRLTTAEVEL 295 Query: 377 R-NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRIC 435 ++P G +L ++ + D PE+F+ L+ +++N + F AG C Sbjct: 296 SGGQVLPAGAVVLPAVATANRD------PEVFEDGERLN---VTRENNPHLAFGAGIHHC 346 Query: 436 VGEGLARMELFLFLTFILQNFNLKSLIDPKD---LDTTPVVNGFASVP 480 +G LAR+EL L IL L P+ L + ++ G S+P Sbjct: 347 LGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLP 394 >6GMF-A nrPDB Length = 397 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 47/167 (28%), Positives = 67/167 (40%), Gaps = 28/167 (16%) Query: 291 AADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDA 350 A LL AG ETT++ + AL+ L HPE A Q ++ V A Sbjct: 227 ANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQADLSLV------------------PA 268 Query: 351 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 410 VV EV RY +T DV+ + IP + +L L S D FP+P+ FD Sbjct: 269 VVEEVLRYESPAQCIFRQTMT-DVEIGDERIPARSVVLPLLASANRDESRFPDPDRFD-- 325 Query: 411 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 457 + + + F C+G LAR+E + L +L Sbjct: 326 -------IHRDTKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARLG 365 >1CPT-A nrPDB Length = 428 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 28/184 (15%) Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQ 356 AG +TTS++ A++ L ++PE A + + P + R +V E Sbjct: 267 AGHDTTSSSSGGAIIGLSRNPEQLALAKSD----------PALIPR--------LVDEAV 308 Query: 357 RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416 R+ + + + A+ D + R I +G I+ S S D + F NP+ FD F Sbjct: 309 RWTAPVKSFMRTAL-ADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF---- 363 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGF 476 N + F G +C+G+ LA++E+ +F +L L P L T V G Sbjct: 364 -----PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATNFVGGP 418 Query: 477 ASVP 480 +VP Sbjct: 419 KNVP 422 >3A1L-A nrPDB Length = 425 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/181 (24%), Positives = 77/181 (42%), Gaps = 28/181 (15%) Query: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335 ++ S +++ +V T LL AG ETT+ L A+L L H +V +++ E Sbjct: 233 RDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPE------- 285 Query: 336 SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 T A V E+ RY D ++ D++ ++ IP+G+ ++ L S Sbjct: 286 -----------STPAAVEELMRY-DPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSAN 333 Query: 396 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN 455 D FP+P++ D + + + F G C+G LAR E + L +L Sbjct: 334 RDPARFPDPDVLD---------VHRAAERQVGFGLGIHYCLGATLARAEAEIGLRALLDG 384 Query: 456 F 456 Sbjct: 385 I 385 >4RM4-A nrPDB Length = 396 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 79/199 (39%), Gaps = 32/199 (16%) Query: 258 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 317 N P I L++ E+ + + + E L+ LL AG ETT+ + A+ +L+ P Sbjct: 204 NKPEQDIISILVEAEETGE----KLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETP 259 Query: 318 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 377 V EE+ R H V E R+ P L D + Sbjct: 260 ----GVYEEL--------------RSHPELMPQAVEEALRFRAPAPV-LRRIAKRDTEIG 300 Query: 378 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437 +LI +G +L + S D +F P MFD R + N + F G C+G Sbjct: 301 GHLIKEGDMVLAFVASANRDEAKFDRPHMFDIR---------RHPNPHIAFGHGIHFCLG 351 Query: 438 EGLARMELFLFLTFILQNF 456 LAR+E + LT ++ F Sbjct: 352 APLARLEANIALTSLISAF 370 >3MGX-A nrPDB Length = 415 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 79/202 (39%), Gaps = 28/202 (13%) Query: 279 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 338 + TI+++++ ++L G ETT + A+ L P + +++ V Sbjct: 236 DDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV-------- 287 Query: 339 MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 D VV EV R+ L T DV +P GT ++ L + D Sbjct: 288 ----------DTVVEEVLRWTSPAMHVL-RVTTADVTINGRDLPSGTPVVAWLPAANRDP 336 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 EF +P+ F P +K N + F G C+G LAR+EL + L + + + Sbjct: 337 AEFDDPDTFLP---------GRKPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVSR 387 Query: 459 KSLIDPKDLDTTPVVNGFASVP 480 L VV G+ +P Sbjct: 388 VDLEREPAWLRAIVVQGYRELP 409 >6FSH-A nrPDB Length = 398 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 81/219 (36%), Gaps = 30/219 (13%) Query: 246 EKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTT 305 +K + +M +D D F+ + E + T E L L+ AG + S Sbjct: 188 DKFSRYLLAMIARERKDPGDGFIGSIVAEHGDT---ITDEELRGVCVQLMLAGDDNVSGM 244 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTS 365 + +L LL+HPE A + RG D V E+ RY+ + Sbjct: 245 IGLGVLALLRHPEQIAAL------------------RGDDQSADRAVDELIRYLTVPYAP 286 Query: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425 P DV + +I +G T+L SL D P+ + D + Sbjct: 287 TPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLD---------VTRTPVPH 337 Query: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP 464 + F G C+G L R++L + T + + F L DP Sbjct: 338 VAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADP 376 >4UBS-A nrPDB Length = 393 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 56/244 (22%), Positives = 99/244 (40%), Gaps = 30/244 (12%) Query: 224 DYFPGTHNKLLKNLAFME-SDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEF 282 D+F +LL+ E D ++ ++ ++ ++ D L + +E+ N+ + Sbjct: 159 DFFESQSRRLLRGPGIAEVQDARAQLDDYLYALIDRKRKEPGDGLLDDLIQEQLNRGTVD 218 Query: 283 TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR 342 E LV A LL AG ETT+ + LL+HPE A+++ E Sbjct: 219 RAE-LVSLATLLLIAGHETTANMISLGTFTLLRHPEQLAELRAEP--------------- 262 Query: 343 GHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFP 402 G MP A V E+ R++ I L T D++ I ++ + + + D F Sbjct: 263 GLMP---AAVEELLRFLS-IADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFA 318 Query: 403 NPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLI 462 P+ D + + + + F G C+G+ LAR E+ + L + + L Sbjct: 319 EPDALD---------WHRSARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLA 369 Query: 463 DPKD 466 P D Sbjct: 370 APAD 373 >5EX6-C nrPDB Length = 434 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 44/182 (24%), Positives = 72/182 (39%), Gaps = 27/182 (14%) Query: 283 TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR 342 T E L ++ AG + S + +L LL++PE A + R Sbjct: 258 TDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAAL------------------R 299 Query: 343 GHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFP 402 G +P + V E+ RY+ + P D + +I G T+L SL + D P Sbjct: 300 GDVPAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLP 359 Query: 403 NPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLI 462 + + D +++ + F G C+G LAR+EL + T + + F L Sbjct: 360 DADRLD---------VTREAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLA 410 Query: 463 DP 464 DP Sbjct: 411 DP 412 >3EJB-B nrPDB Length = 404 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 90/221 (40%), Gaps = 41/221 (18%) Query: 243 DILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETT 302 ++++K K H + +D I L EK+K T E T L AG ETT Sbjct: 193 ELIQKRKRHPQ-------QDMISMLLKGREKDK------LTEEEAASTCILLAIAGHETT 239 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLI 362 + ++L LL+HPE K++E + ++G C++ T V E ID+ Sbjct: 240 VNLISNSVLCLLQHPEQLLKLRENPD-LIGTAVEECLRYESPTQMTARVASED---IDI- 294 Query: 363 PTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS 422 C V R +G + L + D F NP++FD + Sbjct: 295 ---------CGVTIR-----QGEQVYLLLGAANRDPSIFTNPDVFDIT---------RSP 331 Query: 423 NYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID 463 N + F G +C+G LAR+E + + +LQ +L D Sbjct: 332 NPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLAD 372 >4TX3-A nrPDB Length = 404 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 78/211 (36%), Gaps = 30/211 (14%) Query: 254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313 +M +D D F+ + E + T E L L+ AG + S + +L L Sbjct: 202 AMMARERKDPGDGFIGSIVAEHGDT---ITDEELRGVCVQLMLAGDDNVSGMIGLGVLAL 258 Query: 314 LKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCD 373 L+HPE A + RG D V E+ RY+ + P D Sbjct: 259 LRHPEQIAAL------------------RGDDQSADRAVDELIRYLTVPYAPTPRTAVED 300 Query: 374 VKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKR 433 V + +I +G T+L SL D P+ + D + + F G Sbjct: 301 VMVADQVIKEGETVLCSLPMANRDRALLPDADRLD---------VTRTPVPHVAFGHGIH 351 Query: 434 ICVGEGLARMELFLFLTFILQNFNLKSLIDP 464 C+G L R++L + T + + F L DP Sbjct: 352 HCLGAALTRLQLRIAYTALWRRFPALQLADP 382 >4MM0-A nrPDB Length = 399 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 98/246 (39%), Gaps = 50/246 (20%) Query: 256 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAAD---------------LLGAGTE 300 D RD ++ +L + K+ + LV TAA+ LL AG E Sbjct: 180 DWTAARDALESYLDGLVAAKRENPGSDLLSALVATAAEDNELTDHDVRSLSLILLLAGYE 239 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360 S L ++L LL+ P+ A+++ +D G +P + V E+ RY Sbjct: 240 PASNQLGSSVLTLLRFPDRLAELR---------------RDPGLLP---SAVEELMRYAP 281 Query: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF- 419 +L DV + IP + +L S + +DPR F D G Sbjct: 282 AGDGALFRVTLEDVTIGDTHIPANSAVLASTQAA-----------NWDPRRFDDPTGLRL 330 Query: 420 -KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF-NLKSLIDPKDLD-TTP--VVN 474 + N G C+G LAR+EL + + +L+ F L D L ++P +++ Sbjct: 331 DRPDNQHTALGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPGSMLS 390 Query: 475 GFASVP 480 GFA +P Sbjct: 391 GFAEIP 396 >1Q5D-A nrPDB Length = 419 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 43/196 (21%), Positives = 83/196 (42%), Gaps = 27/196 (13%) Query: 261 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 320 R+ ++ ++ M + + S + + LV ++ AGT+TT + +A+L LL+ PE Sbjct: 218 RNPLENDVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEAL 277 Query: 321 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYL 380 V+ E P + + EV R+ +++ D+++ Sbjct: 278 ELVKAE----------PGLMRNA--------LDEVLRFDNILRIGTVRFARQDLEYCGAS 319 Query: 381 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGL 440 I KG + + S L D F P++FD R + ++ + + G +C G L Sbjct: 320 IKKGEMVFLLIPSALRDGTVFSRPDVFDVR---------RDTSASLAYGRGPHVCPGVSL 370 Query: 441 ARMELFLFLTFILQNF 456 AR+E + + I + F Sbjct: 371 ARLEAEIAVGTIFRRF 386 >1Z8P-A nrPDB Length = 404 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 84/204 (41%), Gaps = 29/204 (14%) Query: 265 DCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 D L + + + + + + L A LL AG E++ + + LLL HP+ A V+ Sbjct: 209 DDLLSALIRVQDDDDGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVR 268 Query: 325 EEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 384 +D +P V E+ RYI P + +V+ IP+ Sbjct: 269 ---------------RDPSALPNA---VEEILRYI-APPETTTRFAAEEVEIGGVAIPQY 309 Query: 385 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME 444 +T+L + + D K+FP+P FD + + + F G C+G LA++E Sbjct: 310 STVLVANGAANRDPKQFPDPHRFD---------VTRDTRGHLSFGQGIHFCMGRPLAKLE 360 Query: 445 LFLFLTFILQNFNLKSL-IDPKDL 467 + L + F SL ID D+ Sbjct: 361 GEVALRALFGRFPALSLGIDADDV 384 >4GGV-A nrPDB Length = 418 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 34/199 (17%) Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 PR+ + L++ E + + T +V A LL G TT+ TL +L L PE Sbjct: 223 TPREDLLTHLVQAEVDGER----LTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPE 278 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT-SLPHAVTCDVKFR 377 V AKV+ DR +P + E R L P+ +L + +V+ Sbjct: 279 VAAKVR---------------ADRSLVP---GAIEEALRV--LSPSAALARGTSREVEVA 318 Query: 378 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437 +IPK ++ L + D ++F +PE++DP + N F G C+G Sbjct: 319 GTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPT---------RDPNPHFGFGRGIHFCLG 369 Query: 438 EGLARMELFLFLTFILQNF 456 LAR+E + L + F Sbjct: 370 APLARLEGRVALNALFDRF 388 >6GK6-A nrPDB Length = 411 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 89/222 (40%), Gaps = 35/222 (15%) Query: 262 DFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTA 321 D I L+ E+E + +E + ++V LL AG ETT + +LLLL HP Sbjct: 213 DLISGLLLAEEQEHKLSPAELS--SMVFL---LLVAGHETTVHLIASGMLLLLSHPAERR 267 Query: 322 KVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLI 381 ++ E+ +VG + V E R S D++ + Sbjct: 268 RLDED-PGLVG-----------------SAVEEALRCEGPAELSTIRWSLEDIELFGARV 309 Query: 382 PKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLA 441 P G + L + D + FP+P+ FD + N + F G C+G LA Sbjct: 310 PAGEGVAAGLLAANRDPQHFPDPDRFD---------IGRSPNRHIGFGGGIHFCLGAMLA 360 Query: 442 RMELFLFLTFILQNF-NLKSLIDPKDL--DTTPVVNGFASVP 480 R+E + + +L+ ++ +D+ P + G A+VP Sbjct: 361 RIEAAIAFSTLLRRLPRIELATSTRDIVWSEWPTIRGPAAVP 402 >1WIY-A nrPDB Length = 389 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/190 (26%), Positives = 77/190 (40%), Gaps = 27/190 (14%) Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 S E + A LL AG ET ++ L ++ LLL P+ +V E Sbjct: 204 SHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAES------------- 250 Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTS--LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD 397 +A + Q + L P + L + + +P+GTT++ L+ + Sbjct: 251 --------EEAALAAFQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLV--LSPYVTQ 300 Query: 398 NKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 457 FP E F P FL E G S + PF G+R+C+G A +E + L + F Sbjct: 301 RLYFPEGEAFQPERFLAERGT--PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFR 358 Query: 458 LKSLIDPKDL 467 L L P+ L Sbjct: 359 LDPLPFPRVL 368 >6A7I-A nrPDB Length = 411 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 86/219 (39%), Gaps = 33/219 (15%) Query: 258 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 317 NP D + LI + + T E +V T ++ AG ETT + + + L HP Sbjct: 205 TNPGDDLTSALIAASENGDH----LTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHP 260 Query: 318 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 377 E KV G + + D V+ E R+ L T D++ Sbjct: 261 EQRKKVL-----------------NGEIGW-DGVIEETLRWNTPTSHVLIRFATEDIEVG 302 Query: 378 NYLIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICV 436 + ++PKG ++ S ++ D +++ P FD + N + F G +C Sbjct: 303 DKILPKGEGLIISFGALGRDEEQYGPTAGEFD---------ATRTPNRHIAFGHGPHVCP 353 Query: 437 GEGLARMELFLFLTFILQNF-NLKSLIDPKDLDTTPVVN 474 G L+R+E + L + + F L + DL P+V Sbjct: 354 GAALSRLEAGIALPALYERFPELDLAVPASDLRNKPIVT 392 >5YSW-A nrPDB Length = 441 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 41/187 (21%), Positives = 84/187 (44%), Gaps = 29/187 (15%) Query: 282 FTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQD 341 T + L+ A LL AG +TT++ L + +LL+ P A ++++ R+ Sbjct: 262 LTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD--------- 312 Query: 342 RGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF 401 V E+ RY+ ++ + D++F IP G+T++ S+ + D + + Sbjct: 313 ---------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHW 363 Query: 402 PNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF-NLKS 460 P+P++ + + F G C+G+ LARME+ +L+ N++ Sbjct: 364 PDPDL----------DLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRL 413 Query: 461 LIDPKDL 467 + P+++ Sbjct: 414 AVPPEEV 420 >6F0B-A nrPDB Length = 395 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 46/189 (24%), Positives = 76/189 (40%), Gaps = 27/189 (14%) Query: 257 INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKH 316 + +P + + LI+ Q+ + T + L+ G +TT++T+ +L+ Sbjct: 193 VQDPSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTASTISLSLVSYALQ 252 Query: 317 PEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF 376 PE + V E ER+ P + V E+ RY + L T DV+ Sbjct: 253 PEKFSVVHEHPERI------PLL------------VEELLRYHTVSQLGLGRIATEDVEV 294 Query: 377 RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICV 436 + G ++ +L D FPNP+ D D + S + F G CV Sbjct: 295 GGVTVRAGQMVVAALPLANRDESVFPNPDELD----FD-----RPSVPHVGFGYGPHQCV 345 Query: 437 GEGLARMEL 445 G+ LAR+EL Sbjct: 346 GQALARVEL 354 >6A7J-A nrPDB Length = 411 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 53/245 (21%), Positives = 100/245 (40%), Gaps = 41/245 (16%) Query: 232 KLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITA 291 +++ +L + + I+E+ K NP D + LI ++ + T E ++ T Sbjct: 187 QMMADLGTLFTKIVEEKKA--------NPGDDLTSALIAASEDGDH----LTDEEILNTL 234 Query: 292 ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAV 351 ++ AG ETT + + + L HPE KV G +P+ + V Sbjct: 235 QLIIAAGHETTISLIVNVVEALAIHPEQRKKVLS-----------------GEIPW-EGV 276 Query: 352 VHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEMFDPR 410 + E R+ L T D++ + ++PKG ++ S ++ D +++ P FD Sbjct: 277 IEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFD-- 334 Query: 411 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF-NLKSLIDPKDLDT 469 + N + F G +C G L+R+E + L + + F L + +L Sbjct: 335 -------ATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAAELRN 387 Query: 470 TPVVN 474 P+V Sbjct: 388 KPIVT 392 >5LIV-A nrPDB Length = 450 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 56/234 (23%), Positives = 94/234 (40%), Gaps = 40/234 (17%) Query: 233 LLKNLAFME--SDILEKVKEHQESMDI------NNPRDFIDCFLIKMEKEKQNQQSEFTI 284 +L+ L M + + E + + E++ + RD D L ++ + + + + TI Sbjct: 208 MLRGLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMD-TI 266 Query: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344 E L+ G ETTS + + LL HP+ A+V+ QD Sbjct: 267 EASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVR---------------QDPSL 311 Query: 345 MPYTDAVVHEVQRYIDLIPTSLP--HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFP 402 +P A + E R+ P+S V DV+ + + GT + + + +D +P Sbjct: 312 LP---AAIEEGMRW---CPSSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYP 365 Query: 403 NPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 +PE++D N F G CVG LARME + L +L F Sbjct: 366 SPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVGLQALLARF 411 >5NWS-A nrPDB Length = 435 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 53/251 (21%), Positives = 102/251 (40%), Gaps = 51/251 (20%) Query: 214 QICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEK 273 ++ ++FP +IDY H + + A + D+L + LI+ + Sbjct: 210 RLRHSFPVMIDY---CHRLIEQRRAALTDDLLSE--------------------LIRAQD 246 Query: 274 EKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGR 333 + + S+ +++T L+ AG ET++ + LL HP A ++++ Sbjct: 247 DDGGRLSDIETVTMILT---LVLAGHETSAHLIGNGTAALLTHPGQWALLRKD------- 296 Query: 334 NRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTS 393 P + R VHE+ R+ + + T D++ + +G + L S Sbjct: 297 ---PALLPR--------AVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVS 345 Query: 394 VLHDNKEFPNPEMFD-PRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFI 452 D + + +P+ D RH EG ++ + F G C+G LAR E + L + Sbjct: 346 ANFDPRHYSDPDRLDITRH--QEG----QAENHVGFGHGIHYCLGATLARQEGEVALARL 399 Query: 453 LQNFNLKSLID 463 L+ + +L D Sbjct: 400 LETYPDLALAD 410 >5L1U-A nrPDB Length = 401 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 99/419 (23%), Positives = 154/419 (36%), Gaps = 93/419 (22%) Query: 46 DIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAER 105 DI ++ + L K GP+ + E ++ Y+ V+ L D S P A+ Sbjct: 16 DIMGIAPQMLALQK-EGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKS 74 Query: 106 ANRGFGIVFSNG-------KRWKEIR-----RFSLMTLRNFGMGKRSIEDRVQEEARCLV 153 A R F + + G R ++R RFS LR + K IE V E L+ Sbjct: 75 AARAFMVALAAGDDHETEPARHAQMRSLLIPRFSTRRLR---LMKTRIEHHVDE----LL 127 Query: 154 EELRKTKASPCDPTFILGCA-PCNVICSII---FQKRFDYKDQQFLNLMEKLNENIRIVS 209 ++L A P D +L P V+C ++ R + + NE+ Sbjct: 128 DQL-AASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHS---- 182 Query: 210 TPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLI 269 N F ++DY +LE V + P D I LI Sbjct: 183 ------ANTFQQVVDY------------------MLELVARKR-----VEPGDDILSELI 213 Query: 270 KMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 EK S+ I +L +L G ETT + LLLL++P VQ Sbjct: 214 A---EKDGALSDADIAHL---GNAVLLFGYETTIVRIDLGTLLLLRNP-----VQ----- 257 Query: 330 VVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTS---LPHAVTCDVKFRNYLIPKGTT 386 R+ +D G P A V E+ R S +P D+ +I G Sbjct: 258 -----RAQLAEDPGLAP---AAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDA 309 Query: 387 ILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 ++ ++ + +D++ FP+ +FD + + F G R C+G LAR+EL Sbjct: 310 VMLAIGAANYDDRAFPDGGLFDLTRV--------RPRSHLAFGHGARHCIGRTLARIEL 360 >3SN5-A nrPDB Length = 491 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 87/213 (40%), Gaps = 35/213 (16%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERV-------VGRNRSP-CMQ--DRG 343 +L A T ++L ++++PE EE++R V +P C+ + Sbjct: 265 VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELN 324 Query: 344 HMPYTDAVVHEVQRY--IDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE- 400 +P D+++ E R L + T ++ +Y I K I+ ++H + E Sbjct: 325 DLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDD-IIALYPQLMHLDPEI 383 Query: 401 FPNPEMFDPRHFLDEGGNFKKS---------NYFMPFSAGKRICVGEGLARMELFLFLTF 451 +P+P F +LDE G K + Y+MPF +G IC G A E+ FL Sbjct: 384 YPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLIL 443 Query: 452 ILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484 +L F L+ ++ G A PP Q Sbjct: 444 MLSYFELE------------LIEGQAKCPPLDQ 464 >5Y1I-A nrPDB Length = 403 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 74/182 (40%), Gaps = 25/182 (13%) Query: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335 Q + E T ++ LLGAG ETT+ + L LL++PE A+V++ + V N Sbjct: 216 QVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVRDSDDPKVIVN- 274 Query: 336 SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 V E+ RY+ + ++ D++ +I G I+ L + Sbjct: 275 ---------------TVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAAN 319 Query: 396 HDNKEFPN-PEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQ 454 D +P P+ D + + F G C+G LAR+EL + + +L+ Sbjct: 320 WDPDLYPEAPDRLDIHR--------ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLR 371 Query: 455 NF 456 Sbjct: 372 RI 373 >3P3Z-A nrPDB Length = 416 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 40/165 (24%), Positives = 62/165 (37%), Gaps = 29/165 (17%) Query: 281 EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ 340 ++ + LV T +L AG ETT+ L A+ +HP+ K++E E Sbjct: 240 DYELRTLVAT---VLVAGYETTNHQLALAMYDFAQHPDQWMKIKENPE------------ 284 Query: 341 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400 V EV R+ +P + D + IP GT + D + Sbjct: 285 ------LAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRV 338 Query: 401 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 F + + FD K+ + F G C+G LAR+EL Sbjct: 339 FADADRFDI--------TVKREAPSIAFGGGPHFCLGTALARLEL 375 >6F88-A nrPDB Length = 400 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/236 (23%), Positives = 94/236 (39%), Gaps = 40/236 (16%) Query: 231 NKLLKNLAFME--SDILEKVKEHQESMDI------NNPRDFIDCFLIKMEKEKQNQQSEF 282 +L+ L M + + E + + E++ + RD D L ++ + + + + Sbjct: 156 RAMLRGLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMD- 214 Query: 283 TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR 342 TIE L+ G ETTS + + LL HP+ A+V+ QD Sbjct: 215 TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVR---------------QDP 259 Query: 343 GHMPYTDAVVHEVQRYIDLIPTSLP--HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400 +P A + E R+ P++ V DV+ + + GT + + + +D Sbjct: 260 SLLP---AAIEEGMRW---CPSNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETA 313 Query: 401 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 +P+PE++D N F G CVG LARME + L +L F Sbjct: 314 YPSPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVGLQALLARF 361 >5CJE-A nrPDB Length = 393 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/191 (22%), Positives = 69/191 (36%), Gaps = 27/191 (14%) Query: 265 DCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 D L + + + + E L A LL AG ETT + + LL HP+ A + Sbjct: 201 DDLLGDLIRTRAEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAAL- 259 Query: 325 EEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 384 R M D V EV R+ + T+ ++ I +G Sbjct: 260 -----------------RADMTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEG 302 Query: 385 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME 444 ++ L + D P+P +FD + + F G C+G LAR+E Sbjct: 303 DPVMIGLDAAGRDPARHPDPHVFD---------IHRAPQGHLAFGHGIHYCLGAPLARLE 353 Query: 445 LFLFLTFILQN 455 + L +L+ Sbjct: 354 ARVALRSLLER 364 >5XW2-A nrPDB Length = 419 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 87/213 (40%), Gaps = 33/213 (15%) Query: 244 ILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTS 303 +LE ++EH PR + LI+ E + + T ++V A LL AG TT+ Sbjct: 208 MLEYLREHAAECR-RRPRGDLMGKLIEAEVDGRR----LTDNHIVNFAKMLLIAGYLTTT 262 Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIP 363 + +L L +PE A+V+ DR +P ++ E R++ + Sbjct: 263 MLIGNTVLCLDSYPEQAARVR---------------ADRSLIP---GLLEESMRFLSPVA 304 Query: 364 TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423 + A T DV+ + ++ + D ++F PE+FD + N Sbjct: 305 ATY-RATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFD---------MTRGPN 354 Query: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 + F G C+G LARME + L +L F Sbjct: 355 PHLGFGRGIHFCLGGPLARMEGRVALDHLLDRF 387 >2RFC-A nrPDB Length = 343 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/157 (26%), Positives = 63/157 (40%), Gaps = 15/157 (9%) Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360 T ++Y +LL++ E T + + RV+ N P + D + V E RY Sbjct: 174 TMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDEN--PDIIDDA-LKNRSGFVEETLRYYS 230 Query: 361 LIPTSLPHAVTC-DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419 I LPH D N I KG ++ L S D F P++F Sbjct: 231 PIQF-LPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLF----------KI 279 Query: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 + + F G +C+G LAR+E + L IL +F Sbjct: 280 GRREMHLAFGIGIHMCLGAPLARLEASIALNDILNHF 316 >4YZR-A nrPDB Length = 405 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 46/191 (24%), Positives = 75/191 (39%), Gaps = 32/191 (16%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 L+ AG ETT L L LL+H + K++++ E + V Sbjct: 238 LVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIA------------------TAVE 279 Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413 E+ RY + D ++ + I +G I + S D F NPE+ Sbjct: 280 ELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEIL------ 333 Query: 414 DEGGNFKKS-NYFMPFSAGKRICVGEGLARMELFLFLTFILQNF-NLKSLIDPKDLDTTP 471 N +S N + F G C+G LAR+E + +L+ F +++ + P D+ Sbjct: 334 ----NINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRK 389 Query: 472 VV--NGFASVP 480 V G S+P Sbjct: 390 NVFLRGLESLP 400 >3JUS-A nrPDB Length = 461 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 88/224 (39%), Gaps = 26/224 (11%) Query: 261 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAAD--------------------LLGAGTE 300 R+ D F ++K +Q+Q+ I++++ T D LL AG Sbjct: 210 REIKDIFYKAIQKRRQSQEK---IDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQH 266 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR-GHMPYTDAVVHEVQRYI 359 T+STT + L + + K E + V G N P D+ + D + E R Sbjct: 267 TSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLR 326 Query: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419 I + A T Y IP G + S T + F+P +L + Sbjct: 327 PPIMIMMRMARTPQT-VAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPAS 385 Query: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID 463 + ++PF AG+ C+GE A +++ + +L+ + LID Sbjct: 386 GEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF-DLID 428 >3WVS-A nrPDB Length = 401 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 46/190 (24%), Positives = 81/190 (42%), Gaps = 28/190 (14%) Query: 268 LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEI 327 LI E ++ Q + T + L+ LL AG ETT++ + + LL P+ ++ ++ Sbjct: 212 LISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDDP 271 Query: 328 ERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL-IPTSLPHAVTCDVKFRNYLIPKGTT 386 E + + V E+ R++ L ++ P D++ L+ G Sbjct: 272 ELI------------------PSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEP 313 Query: 387 ILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELF 446 +L +L + D F +PE LD + SN+ + F G C+G LAR+EL Sbjct: 314 VLVALGAANRDGLRFEDPEEIK----LD-----RPSNHHIGFGHGIHHCLGAPLARLELQ 364 Query: 447 LFLTFILQNF 456 L +L+ Sbjct: 365 EALRALLERL 374 >1UE8-A nrPDB Length = 367 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 43/188 (22%), Positives = 81/188 (43%), Gaps = 19/188 (10%) Query: 293 DLLGAGTETTSTTLR---YALLLLLKHPEVTAK-VQEEIERVVGRNRSPCMQDRGHMPYT 348 DL G + + L Y +LL++ E T + IE N ++++G + Sbjct: 185 DLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAIEDFTLYNSWDYVREKGAL--- 241 Query: 349 DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD 408 V E R+ + ++ VK R+ +I +G + + S D + F +P+ F Sbjct: 242 -KAVEEALRFSPPVMRTI-RVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFI 299 Query: 409 PRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLD 468 P + N + F +G +C+G LAR+E + L + F +K ++ + +D Sbjct: 300 PD---------RTPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEIVKKEKID 350 Query: 469 TTPVVNGF 476 V+NG+ Sbjct: 351 NE-VLNGY 357 >3R9C-A nrPDB Length = 418 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 43/181 (23%), Positives = 68/181 (37%), Gaps = 28/181 (15%) Query: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335 + + T + ++ T LL AG ETT + A L +L+ P A + + R Sbjct: 235 EESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSRA----- 289 Query: 336 SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 AV+ E RY + +A D+ + +PKG T+L L + Sbjct: 290 -------------SAVIEETMRYDPPVQLVSRYAGD-DLTIGTHTVPKGDTMLLLLAAAH 335 Query: 396 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN 455 D P+ FDP + + F G C+G LAR+E + L + Sbjct: 336 RDPTIVGAPDRFDPD---------RAQIRHLGFGKGAHFCLGAPLARLEATVALPALAAR 386 Query: 456 F 456 F Sbjct: 387 F 387 >5YHJ-A nrPDB Length = 413 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 32/103 (31%), Positives = 47/103 (45%), Gaps = 11/103 (10%) Query: 341 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400 +RG + T+ V EV+R+ P + V D ++ Y P+GT L L HD Sbjct: 266 ERGEVSKTE-FVQEVRRFYPFFPVAAAR-VKTDFEWDGYAFPEGTLTLLDLYGTNHDVSI 323 Query: 401 FPNPEMFDPRHFLDEGGNFKKSNY-FMPFSAGK----RICVGE 438 + P+ FDP F D +K+S + F+P G C GE Sbjct: 324 WTEPDRFDPSRFKD----WKESPFNFIPQGGGDVDFGHRCAGE 362 >3A50-A nrPDB Length = 411 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 83/224 (37%), Gaps = 39/224 (17%) Query: 222 IIDYFPGT-HNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS 280 ++D P N + L SD+LE+ + P D + L+ + ++ S Sbjct: 171 LVDDSPADDKNAAMGKLHGYLSDLLERKR--------TEPDDALLSSLLAVSDMDGDRLS 222 Query: 281 EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ 340 + E LV A LL AG ETT + +L LL HP+ + E+ P + Sbjct: 223 Q---EELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAED----------PSL- 268 Query: 341 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400 + V E R+ + + DV + IP G ++ L + D Sbjct: 269 -------ISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADW 321 Query: 401 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME 444 P P+ D GG F F G C+G LAR+E Sbjct: 322 MPEPDRLDITRDA-SGGVF--------FGHGIHFCLGAQLARLE 356 >5HH3-A nrPDB Length = 397 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 71/185 (38%), Gaps = 30/185 (16%) Query: 281 EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ 340 E T L AA ++GAG + + L L+ PE A ++E+ + V P Sbjct: 222 EITDAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREKPDTV------PDWL 275 Query: 341 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400 D EV RY+ + P T DV+ ++LI G T+ SL + + + Sbjct: 276 D------------EVIRYLTTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAA--NRRN 321 Query: 401 FPNPE-MFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459 FP PE FD E + F G C+G LA + + + F Sbjct: 322 FPRPEDRFDITRVRPE---------HLAFGHGIHHCLGRSLAELVFRTAIPALAHRFPTL 372 Query: 460 SLIDP 464 L +P Sbjct: 373 RLAEP 377 >5IT1-A nrPDB Length = 399 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/206 (24%), Positives = 77/206 (37%), Gaps = 31/206 (15%) Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NP D + LI E F L+ A LL A +TT+ + LLL P+ Sbjct: 203 NPGDDLISALITTEDPDGVIDDMF----LMNAAGTLLIAAHDTTACMIGLGTALLLDRPD 258 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 A +Q++ ++G V E+ RY+ + T D + Sbjct: 259 QLALLQKD-PSLIGN-----------------AVEELLRYLTIGQFGAERVATQDGEIGG 300 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 I KG ++T L S D +PE FD ++ + F G C+G+ Sbjct: 301 VRIAKGEQVVTHLLSADFDPAFVEDPERFD---------ITRRPAPHLAFGFGAHQCIGQ 351 Query: 439 GLARMELFLFLTFILQNFNLKSLIDP 464 LAR+EL + + + F L P Sbjct: 352 QLARIELQIVFGTLFRRFPTLRLAKP 377 >2IJ7-A nrPDB Length = 396 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 44/192 (22%), Positives = 69/192 (35%), Gaps = 26/192 (13%) Query: 275 KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRN 334 K S + E GAG +T + L AL+ L++ P++ + E+ E + Sbjct: 211 KDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELI---- 266 Query: 335 RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSV 394 A V E+ R LP T D++ + L+ KG +L L Sbjct: 267 --------------PAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGA 312 Query: 395 LHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQ 454 D + FPNP + LD + F G+ C G L R + + +L+ Sbjct: 313 NFDPEHFPNPGSIE----LDR----PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLK 364 Query: 455 NFNLKSLIDPKD 466 L P D Sbjct: 365 KMPGVDLAVPID 376 >3OO3-A nrPDB Length = 384 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 44/197 (22%), Positives = 76/197 (38%), Gaps = 33/197 (16%) Query: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335 + +E + E L A L E + L A+LLL+ HP+ A ++E+ E + Sbjct: 205 REHGAEISDEELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPELI----- 259 Query: 336 SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 D+ EV R+ ++ P DV+ I G + S+ + Sbjct: 260 -------------DSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLA-- 304 Query: 396 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN 455 P + FD ++ M F G C+G LAR++L + L ++ Sbjct: 305 --TNRAPG-DRFD---------ITREKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGR 352 Query: 456 F-NLKSLIDPKDLDTTP 471 F +L+ + +DL P Sbjct: 353 FPSLRLAVPEEDLRFKP 369 >2XKR-A nrPDB Length = 398 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 55/226 (24%), Positives = 92/226 (40%), Gaps = 37/226 (16%) Query: 259 NPRDFIDCFLIKMEKEKQN-QQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 317 +P D + L+ E + + E +E L+I L+G G ETT TL LL++ Sbjct: 196 DPTDDLVSVLVSSEVDGERLSDDELVMETLLI----LIG-GDETTRHTLSGGTEQLLRNR 250 Query: 318 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 377 + +Q R P + +P + E+ R+ + ++ +T D +F Sbjct: 251 DQWDLLQ----------RDPSL-----LP---GAIEEMLRWTAPV-KNMCRVLTADTEFH 291 Query: 378 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437 + G ++ S D F PE FD + + N + F G C+G Sbjct: 292 GTALCAGEKMMLLFESANFDEAVFCEPEKFDVQ---------RNPNSHLAFGFGTHFCLG 342 Query: 438 EGLARMELFLFLTFILQNF-NLKSLIDPKDLDTTPV--VNGFASVP 480 LAR+EL L +L+ +L+ + D L P V+G S+P Sbjct: 343 NQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMP 388 >1LG9-A nrPDB Length = 398 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 39/168 (23%), Positives = 65/168 (38%), Gaps = 27/168 (16%) Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQ 356 AG + S + +L +L+HPE +I+ G +S V E+ Sbjct: 236 AGDDNISGMIGLGVLAMLRHPE-------QIDAFRGDEQS-----------AQRAVDELI 277 Query: 357 RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416 RY+ + + P D+ I KG +++ SL + D P+ + D Sbjct: 278 RYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLD-------- 329 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP 464 ++ + F G C+G LAR+EL T + + F L DP Sbjct: 330 -VTREPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADP 376 >1GWI-A nrPDB Length = 411 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 82/217 (37%), Gaps = 32/217 (14%) Query: 260 PRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEV 319 P D + LI+ + + T +V T ++ AG ETT + + A++ L HPE Sbjct: 209 PGDDLTSALIQASENGDH----LTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQ 264 Query: 320 TAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNY 379 A V G ++ AVV E R+ L DV + Sbjct: 265 RALVLS-----------------GEAEWS-AVVEETLRFSTPTSHVLIRFAAEDVPVGDR 306 Query: 380 LIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 +IP G ++ S ++ D + P + FD N + F G +C G Sbjct: 307 VIPAGDALIVSYGALGRDERAHGPTADRFDL--------TRTSGNRHISFGHGPHVCPGA 358 Query: 439 GLARMELFLFLTFILQNF-NLKSLIDPKDLDTTPVVN 474 L+RME + L + F +L + +L PVV Sbjct: 359 ALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVT 395 >4TRI-A nrPDB Length = 407 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 55/231 (23%), Positives = 86/231 (37%), Gaps = 36/231 (15%) Query: 260 PRDFIDCFLIKMEKEKQN-QQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 P D + L+ E E Q E E L+I L+G G ETT TL LL+H + Sbjct: 200 PTDDLFSVLVNSEVEGQRMSDDEIVFETLLI----LIG-GDETTRHTLSGGTEQLLRHRD 254 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 + +++ + G + E+ R+ + ++ +T D F Sbjct: 255 QWDALVADVDLLPG------------------AIEEMLRWTSPV-KNMCRTLTADTVFHG 295 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 + G I+ S D F +P+ F +D + N + F G C+G Sbjct: 296 TELRAGEKIMLMFESANFDESVFGDPDNF----RID-----RNPNSHVAFGFGTHFCLGN 346 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 LAR+EL L +L+ L D + P F S P + F P Sbjct: 347 QLARLELRLMTERVLRRLPDLRLADDAPVPLRPA--NFVSGPESMPVVFTP 395 >5Z9I-A nrPDB Length = 398 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 46/185 (24%), Positives = 77/185 (41%), Gaps = 32/185 (17%) Query: 260 PRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEV 319 PR+ + L+ E + Q + ++ I N+ A LL G TT+ + +L L + Sbjct: 204 PREDLISQLVHAEVDGQ-KLNDSQISNI---ANRLLVNGHLTTAMLIANTMLCLDAFSDQ 259 Query: 320 TAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNY 379 A+V+ DR +P A++ E RY+ I + A +V+ Sbjct: 260 DARVR---------------ADRSLVP---ALLEESMRYMSPI-CGVGRATNSEVEVAGT 300 Query: 380 LIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEG 439 +IPK +L + D ++F P++FD + N + F G C+G Sbjct: 301 VIPKDQLLLVWTGAANRDERQFEKPDVFDA---------GRSPNAHLGFGRGIHFCLGRQ 351 Query: 440 LARME 444 LARME Sbjct: 352 LARME 356 >6FYJ-A nrPDB Length = 421 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 12/102 (11%) Query: 343 GHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFP 402 G Y+ V EV+R+ P + V D ++ Y +GT L L HD + + Sbjct: 275 GDKKYSQMFVQEVRRFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWK 333 Query: 403 NPEMFDPRHFLD-EGGNFK-----KSNYFMPFSAGKRICVGE 438 NP++F P F EG F +YFM G R C GE Sbjct: 334 NPDVFSPDRFAKWEGSPFSFIPQGGGDYFM----GHR-CAGE 370 >2IAG-A nrPDB Length = 482 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/171 (25%), Positives = 72/171 (42%), Gaps = 30/171 (17%) Query: 314 LKHPEVTAKVQEEIERVVGRNRSPCMQDR-------GHMPYTDAVVHEVQRYIDLIPTSL 366 LK+PE A V+ E+E ++ + P Q P D+V+ E R T+ Sbjct: 278 LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-----TAA 332 Query: 367 P---HAVTCDVKF-----RNYLIPKGTTILT-SLTSVLHDNKEFPNPEMFDPRHFLDEGG 417 P V D+ R + + +G +L S D + + +PE+F FL+ G Sbjct: 333 PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDG 392 Query: 418 NFKKS---------NYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459 + KK NY MP+ AG C+G A + F+ +L + +L+ Sbjct: 393 SEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLE 443 Score = 28.5 bits (62), Expect = 6.6, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 9/61 (14%) Query: 31 PGPTPL-----PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL---HGYEV 82 PG PL P +G L KD + LT + + +G +FT+ G + VL H Y+ Sbjct: 5 PGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDA 63 Query: 83 V 83 V Sbjct: 64 V 64 >4Z5P-A nrPDB Length = 400 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/193 (22%), Positives = 78/193 (40%), Gaps = 30/193 (15%) Query: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335 ++ T + L+ LL AG ET++ L + LL H + + ++E+ Sbjct: 216 RDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQ--------- 266 Query: 336 SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC--DVKFRNYLIPKGTTILTSLTS 393 P + R V E+ R++ L + +A DV+ + G ++ + + Sbjct: 267 -PELLPR--------AVEELLRFVPL-GNGVGNARIALEDVELSGGTVRAGEGVVAAAVN 316 Query: 394 VLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFIL 453 D + F +P+ D ++ N + F G C+G LARMEL + + +L Sbjct: 317 ANRDPRAFDDPDRLD---------ITREKNPHLAFGHGAHYCLGAQLARMELRVAIGGLL 367 Query: 454 QNFNLKSLIDPKD 466 + F L P D Sbjct: 368 ERFPGLRLAVPAD 380 >1ODO-A nrPDB Length = 408 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 85/205 (41%), Gaps = 20/205 (9%) Query: 284 IENLVITAADLLGAGTETTSTTLRYALLLLLKHP-EVTAKV-QEEIERVVGRNRSPCMQD 341 + +L+I A D G G + LR LLL++ E T V + + ++ R + Sbjct: 210 MTSLLIAARDDEGDGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVR 269 Query: 342 RGHMPYTDAVVHEVQRY---IDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 +G + + D VV E R+ + +P L +AVT I +G IL S + Sbjct: 270 KGEVTWAD-VVEETLRHEPAVKHLP--LRYAVTDIALPDGRTIARGEPILASYAAANRHP 326 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 + + FD + E + F G C+G LARME+ L L + F Sbjct: 327 DWHEDADTFDATRTVKE---------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPD 377 Query: 459 KSLIDP-KDLDTTP--VVNGFASVP 480 L DP ++L P + NG +P Sbjct: 378 LRLADPAEELPPVPSLISNGHQRLP 402 >5EX8-A nrPDB Length = 424 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 70/183 (38%), Gaps = 28/183 (15%) Query: 283 TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR 342 T L AA ++GA + + L L+++ P A ++E+ E V P D Sbjct: 251 TDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETV------PEWLD- 303 Query: 343 GHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFP 402 E RY+ + P T DV+ N L+ G T+ SL + N +P Sbjct: 304 -----------ETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANRPN--YP 350 Query: 403 NPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLI 462 + E DE ++ + F G C+G +A + + + + F L Sbjct: 351 SAE--------DEFDITREKAEHLAFGHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLA 402 Query: 463 DPK 465 DP+ Sbjct: 403 DPQ 405 >5L94-A nrPDB Length = 410 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/195 (24%), Positives = 78/195 (40%), Gaps = 33/195 (16%) Query: 262 DFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTA 321 D I L E+ KQ T E +V + LL AG ETT+ + + L++ Sbjct: 212 DIISVLLQAKEEGKQ-----LTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFE 266 Query: 322 KVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLI 381 +++ E E + + + EV RY + +L V DV + Sbjct: 267 RLKREKELL------------------PSGIEEVLRYRSPV-QALHRIVKEDVTLAGKKL 307 Query: 382 PKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLA 441 G ++ + S D + F +PE+F +D +K N M F G C+G LA Sbjct: 308 KAGEHVVPWMGSAHRDAEYFEDPEVFK----ID-----RKPNVHMAFGRGIHFCLGAPLA 358 Query: 442 RMELFLFLTFILQNF 456 R+E + L ++ + Sbjct: 359 RIEAKIMLAELIDRY 373 >6GII-A nrPDB Length = 479 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 8/80 (10%) Query: 370 VTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFS 429 T +V+ +P G IL + S HD+ F +PE FD G S + + F Sbjct: 362 TTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDI-------GRSNASEH-LNFG 413 Query: 430 AGKRICVGEGLARMELFLFL 449 G C+G L RME+ + + Sbjct: 414 YGAHQCLGRNLGRMEMQIMI 433 >2FR7-A nrPDB Length = 412 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/204 (21%), Positives = 80/204 (39%), Gaps = 28/204 (13%) Query: 277 NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRS 336 + E T E + LL AG +TT + A+ L + P+ A+++ + + RN Sbjct: 231 SDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPS--LARN-- 286 Query: 337 PCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLH 396 E R+ + T T DV+ I +G +L L S Sbjct: 287 --------------AFEEAVRFESPVQTFF-RTTTRDVELAGATIGEGEKVLMFLGSANR 331 Query: 397 DNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 D + + +P+ +D +K++ + F +G +CVG+ +AR+E + L + + Sbjct: 332 DPRRWDDPDRYD---------ITRKTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKV 382 Query: 457 NLKSLIDPKDLDTTPVVNGFASVP 480 + P + G S+P Sbjct: 383 AAIEIAGPLKRRFNNTLRGLESLP 406 >2X9P-A nrPDB Length = 404 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/172 (25%), Positives = 65/172 (37%), Gaps = 28/172 (16%) Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 E T + + A LL AG ++ ++ + ++LL HP+ R+ + Sbjct: 224 GELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPD---------------QRAAAL 268 Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSLP-HAVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 D M V EV R + LP + D++F I G +L L D Sbjct: 269 ADPDVMAR---AVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDE 325 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT 450 + F PE FD + N + F G C+G LAR+EL T Sbjct: 326 RAFTGPEEFD---------AARTPNPHLTFGHGIWHCIGAPLARLELRTMFT 368 >2WIO-A nrPDB Length = 431 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 79/205 (38%), Gaps = 20/205 (9%) Query: 256 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315 D+ NP + +L E++ + I LV+ D E + ++ LLL Sbjct: 208 DVLNP---LTAYLKARCAERRADPGDDLISRLVLAEVDGRALDDEEAAN---FSTALLLA 261 Query: 316 HPEVTAKVQEEIERVVGRNRS---PCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC 372 T + I R + + + +D G +P A+V EV RY P + T Sbjct: 262 GHITTTVLLGNIVRTLDEHPAHWDAAAEDPGRIP---AIVEEVLRYRPPFP-QMQRTTTK 317 Query: 373 DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK 432 + IP + T + S D+ +P+ FDP GG + S F G Sbjct: 318 ATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR--KSGGAAQLS-----FGHGV 370 Query: 433 RICVGEGLARMELFLFLTFILQNFN 457 C+G LAR+E + L I+ F Sbjct: 371 HFCLGAPLARLENRVALEEIIARFG 395 >4YT3-A nrPDB Length = 410 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 83/200 (41%), Gaps = 34/200 (17%) Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALL-LLLKHP 317 NP D I L+K E + + FT + +V T +LGAG ETTS L + LL Sbjct: 209 NPADDIISDLLKSEVDGEM----FTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDK 264 Query: 318 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRY-IDLIPTSLPHAVTCDVKF 376 EV ++ E ++ V V E+ R+ +LI L V D Sbjct: 265 EVYQELHENLDLV------------------PQAVEEMLRFRFNLI--KLDRTVKEDNDL 304 Query: 377 RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICV 436 + +G +++ +++ D + F +P + N KK + F G C+ Sbjct: 305 LGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHR-----PNNKK---HLTFGNGPHFCL 356 Query: 437 GEGLARMELFLFLTFILQNF 456 G LAR+E + LT L+ F Sbjct: 357 GAPLARLEAKIALTAFLKKF 376 >5HIW-A nrPDB Length = 398 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 9/76 (11%) Query: 381 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGL 440 + GT + SL + +D + +P PE FD ++ + F G CVG L Sbjct: 293 LAAGTILYLSLIARHYDEEIYPRPETFD---------IHRRPVGMLNFGGGLHYCVGAPL 343 Query: 441 ARMELFLFLTFILQNF 456 ARME + ++ +L+ F Sbjct: 344 ARMEARVGVSLLLERF 359 >5DE9-A nrPDB Length = 410 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 75/192 (39%), Gaps = 32/192 (16%) Query: 279 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 338 + E T+ V A LL G E + LLL PE+ +++ E P Sbjct: 224 RDEITLSEAVGLAV-LLQIGGEAVTNNSGQMFHLLLSRPELAERLRSE----------PE 272 Query: 339 MQDRGHMPYTDAVVHEVQRYI-DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD 397 ++ R + E+ R+I L DV+ + I G + S + D Sbjct: 273 IRPRA--------IDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRD 324 Query: 398 NKEFPNPEMFDPRHFLDEGGNFKKS-NYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 + FP+P+ D F++S N + F G C G LAR+E L + +L Sbjct: 325 PEVFPDPDRID----------FERSPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRV 374 Query: 457 -NLKSLIDPKDL 467 LK + P+D+ Sbjct: 375 PGLKLAVAPEDV 386 >5GWE-A nrPDB Length = 405 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 72/183 (39%), Gaps = 31/183 (16%) Query: 262 DFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTA 321 D + L++ ++E Q E T + LL AG ETT+T + +LL HPE Sbjct: 211 DNLTADLVRAQQEGQ----EITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQ 266 Query: 322 KVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLI 381 + E +P + +P A V EV RY I A+ D + I Sbjct: 267 AILE----------NPKL-----IP---AAVDEVLRYSGSIVGWRRKALK-DTEIGGVAI 307 Query: 382 PKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLA 441 +G +L + S D F N E FD + + + F G C+G LA Sbjct: 308 KEGDGVLLLMGSANRDEARFENGEEFDI--------SRANAREHLSFGFGIHYCLGNMLA 359 Query: 442 RME 444 +++ Sbjct: 360 KLQ 362 >5XJN-A nrPDB Length = 455 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 72/183 (39%), Gaps = 31/183 (16%) Query: 262 DFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTA 321 D + L++ ++E Q E T + LL AG ETT+T + +LL HPE Sbjct: 261 DNLTADLVRAQQEGQ----EITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQ 316 Query: 322 KVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLI 381 + E +P + +P A V EV RY I A+ D + I Sbjct: 317 AILE----------NPKL-----IP---AAVDEVLRYSGSIVGWRRKALK-DTEIGGVAI 357 Query: 382 PKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLA 441 +G +L + S D F N E FD + + + F G C+G LA Sbjct: 358 KEGDGVLLLMGSANRDEARFENGEEFDI--------SRANAREHLSFGFGIHYCLGNMLA 409 Query: 442 RME 444 +++ Sbjct: 410 KLQ 412 >5XNT-A nrPDB Length = 411 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 83/201 (41%), Gaps = 36/201 (17%) Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALL-LLLKHP 317 NP D I L+K E + + FT + +V T +LGAG ETTS L + LL Sbjct: 209 NPADDIISDLLKAEVDGEM----FTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDK 264 Query: 318 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRY-IDLIPTSLPHAVTCDVKF 376 EV ++ E ++ V V E+ RY +LI L V D Sbjct: 265 EVYQELHENLDLV------------------PQAVEEMLRYRFNLI--KLDRTVKEDNDL 304 Query: 377 RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLD-EGGNFKKSNYFMPFSAGKRIC 435 + +G ++ +++ D EMF+ L+ N KK + F G C Sbjct: 305 LGVELKEGENVVVWMSAANLDE------EMFEDAFTLNIHRPNNKKH---LTFGNGPHFC 355 Query: 436 VGEGLARMELFLFLTFILQNF 456 +G LAR+E + LT L+ F Sbjct: 356 LGAPLARLEAKIALTTFLKKF 376 >5M0P-A nrPDB Length = 428 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 27/66 (40%), Gaps = 1/66 (1%) Query: 347 YTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEM 406 Y EV+RY +P LP D+ F+ IP G + + HD + +P Sbjct: 283 YAYKFAQEVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNE 341 Query: 407 FDPRHF 412 F P F Sbjct: 342 FRPERF 347 >5LIE-A nrPDB Length = 414 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 39/173 (22%), Positives = 65/173 (37%), Gaps = 28/173 (16%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 L AG ETT ++ LL L ++P+ ++ + E + + Sbjct: 250 LFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELL------------------PTAIE 291 Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413 E+ R+ P+ A V I G ++ S D P +FD Sbjct: 292 EIVRWTSPSPSKRRTASRA-VSLGGQPIEAGQKVVVWEGSANRD------PSVFD---RA 341 Query: 414 DEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466 DE +K N + F G C+G LAR+EL + +L F +++P + Sbjct: 342 DEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAE 394 >3ABA-A nrPDB Length = 403 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 46/187 (24%), Positives = 70/187 (37%), Gaps = 31/187 (16%) Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NP D + LI E F L+ A LL A +TT+ + LLL P+ Sbjct: 203 NPGDDLISALITTEDPDGVVDDMF----LMNAAGTLLIAAHDTTACMIGLGTALLLDSPD 258 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 A ++E+ +VG V E+ RY+ + T DV+ Sbjct: 259 QLALLRED-PSLVGN-----------------AVEELLRYLTIGQFGGERVATRDVELGG 300 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 I KG ++ + + D PE FD ++ + F G C+G+ Sbjct: 301 VRIAKGEQVVAHVLAADFDPAFVEEPERFD---------ITRRPAPHLAFGFGAHQCIGQ 351 Query: 439 GLARMEL 445 LAR+EL Sbjct: 352 QLARIEL 358 >5FYF-A nrPDB Length = 470 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 47/210 (22%), Positives = 87/210 (41%), Gaps = 32/210 (15%) Query: 270 KMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 K K+ N+ EF I NL + L+ G +TT ++ L+ + + P K++ + E Sbjct: 285 KETKDLINRPMEF-IGNLTL----LIVGGNDTTRNSMSGGLVAMNEFPREFEKLKAKPEL 339 Query: 330 VVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILT 389 + P M V E+ R+ + + DV+ I KG ++ Sbjct: 340 I------PNM------------VSEIIRWQTPL-AYMRRIAKQDVELGGQTIKKGDRVVM 380 Query: 390 SLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFL 449 S D ++F NP+ F +D K + M F G C+G LA ++L + Sbjct: 381 WYASGNRDERKFDNPDQF----IIDR----KDARNHMSFGYGVHRCMGNRLAELQLRILW 432 Query: 450 TFILQNFNLKSLIDPKDLDTTPVVNGFASV 479 IL+ F+ +++ + + V G++ + Sbjct: 433 EEILKRFDNIEVVEEPERVQSNFVRGYSRL 462 >6G71-A nrPDB Length = 405 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 24/96 (25%), Positives = 41/96 (42%), Gaps = 10/96 (10%) Query: 350 AVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDP 409 AV E R++ I +P D + Y IP+G + + S D + +P+ FD Sbjct: 271 AVFEESIRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFD- 328 Query: 410 RHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 ++ G S + F G +C+G AR ++ Sbjct: 329 ---IERG-----SEAHLAFGKGVHVCLGAWAARSQV 356 >4XE3-A nrPDB Length = 407 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 31/116 (26%), Positives = 47/116 (40%), Gaps = 10/116 (8%) Query: 350 AVVHEVQRYIDLIPT-SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD 408 A V E+ RY L+ S T DV+ + G + S D E+FD Sbjct: 279 AAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDE------EVFD 332 Query: 409 PRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP 464 DE ++ N + F G C+G L R+EL L+ +++ F L +P Sbjct: 333 ---HADELDFHRERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEP 385 >4JBT-A nrPDB Length = 410 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 40/181 (22%), Positives = 71/181 (39%), Gaps = 27/181 (14%) Query: 277 NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRS 336 + ++ T E ++ L+ AG ETT + + A+ LL HPE V++ Sbjct: 224 DGETPLTEEEVIGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVRD----------- 272 Query: 337 PCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLH 396 G + + A + E R+ + L T D+ + +IP+G ++ S ++ Sbjct: 273 ------GEIGWETA-IEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGR 325 Query: 397 D-NKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN 455 D + + FD + + F G IC G LAR+E + L + Sbjct: 326 DITVHGADADDFDI--------TRATAARHISFGHGPHICPGAALARLEAAIALPALFTR 377 Query: 456 F 456 F Sbjct: 378 F 378 >2WM5-A nrPDB Length = 435 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 36/156 (23%), Positives = 58/156 (37%), Gaps = 34/156 (21%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 L+ AG ETT + + +L L ++PE + + + G P V Sbjct: 271 LVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFD--------------GLAP---TAVE 313 Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD----P 409 E+ R+ + + +T D++ R + G + S D +F +P FD P Sbjct: 314 EIVRWASPV-VYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNP 372 Query: 410 RHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 L GG G C+G LAR E+ Sbjct: 373 NPHLGFGG------------GGAHFCLGANLARREI 396 >6CVC-A nrPDB Length = 433 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 34/156 (21%), Positives = 58/156 (37%), Gaps = 34/156 (21%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 L+ AG ETT + + +L L ++P+ AK + + + V Sbjct: 268 LVVAGNETTRNAISHGMLALSRYPDERAKWWSDFDGLAA-----------------TAVE 310 Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD----P 409 E+ R+ + + ++ DV R + G + S D ++F +P FD P Sbjct: 311 EIVRWASPV-VYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNP 369 Query: 410 RHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 + GG G C+G LAR E+ Sbjct: 370 NPQVGFGG------------GGAHFCLGANLARREI 393 >5OFQ-A nrPDB Length = 409 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 56/247 (22%), Positives = 93/247 (37%), Gaps = 45/247 (18%) Query: 226 FPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIE 285 F K + + F++ E + E Q+ N D I L E + T E Sbjct: 179 FAKMMQKRNEGVIFLQGYFKEIIAERQQ----NKQEDLISLLL-----EAEIDGEHLTEE 229 Query: 286 NLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHM 345 ++ LL AG ETT+ + + + + +V +V+ +I V Sbjct: 230 EVLGFCILLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDISLVPN------------- 276 Query: 346 PYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPE 405 +V E RY I ++ DV+ I +G +++ S D+ +F P+ Sbjct: 277 -----LVEETLRYYPPI-QAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPD 330 Query: 406 MFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFIL--------QNFN 457 F +K+N + F G C+G LARME + T +L QN + Sbjct: 331 TFVVH---------RKTNPHVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQS 381 Query: 458 LKSLIDP 464 LK + P Sbjct: 382 LKPIDSP 388 >4DO1-A nrPDB Length = 410 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 42/203 (20%), Positives = 83/203 (40%), Gaps = 32/203 (15%) Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 E T + + LL AG +TT + A+ L + P +++ + + RN Sbjct: 232 GEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDP--TLARNA---- 285 Query: 340 QDRGHMPYTDAVVHE--VQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD 397 + +AV E VQ + T +V+ +I +G +L L S D Sbjct: 286 -------FEEAVRFESPVQTFF--------RTTTREVELGGAVIGEGEKVLMFLGSANRD 330 Query: 398 NKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 457 + + +P+++D +K++ + F +G +CVG+ +AR+E + L+ + + Sbjct: 331 PRRWSDPDLYD---------ITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVA 381 Query: 458 LKSLIDPKDLDTTPVVNGFASVP 480 + P + G S+P Sbjct: 382 AIDIDGPVKRRFNNTLRGLESLP 404 >5DQN-A nrPDB Length = 426 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 46/221 (20%), Positives = 82/221 (37%), Gaps = 47/221 (21%) Query: 266 CFLIKMEKEKQNQQSEFTIENLVITAAD---------------LLGAGTETTSTTLRYAL 310 + +KM +E+ +E + L+ D L AG ETT ++ + + Sbjct: 205 SYAMKMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGM 264 Query: 311 LLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 370 + ++P+ ++E P T A E+ R+ + ++ Sbjct: 265 IAFAQNPDQWELYKKE------------------RPETAA--DEIVRWATPV-SAFQRTA 303 Query: 371 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSA 430 DV+ I KG ++ S S D + F +P F+ + N + F Sbjct: 304 LEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFN---------ILRSPNPHVGFGG 354 Query: 431 -GKRICVGEGLARMELFLFLTFILQNF-NLKSLIDPKDLDT 469 G C+G LARM + L I N +LK + P+ L + Sbjct: 355 TGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKS 395 >3AWQ-A nrPDB Length = 415 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 17/66 (25%), Positives = 30/66 (45%), Gaps = 1/66 (1%) Query: 347 YTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEM 406 Y + V EV+R+ P + A + D ++ P+G ++ L HD + +P+ Sbjct: 273 YAELFVQEVRRFYPFFPAVVARA-SQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQE 331 Query: 407 FDPRHF 412 F P F Sbjct: 332 FRPERF 337 >2ZQJ-A nrPDB Length = 417 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 42/95 (44%), Gaps = 12/95 (12%) Query: 352 VHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRH 411 V EV+RY P L V D + N KGT++L L HD + + +P+ F P Sbjct: 280 VQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPER 338 Query: 412 FLDEGGNFKKSNYF--MPFSAGK----RICVGEGL 440 F + ++ N F +P G C GEG+ Sbjct: 339 FAE-----REENLFDMIPQGGGHAEKGHRCPGEGI 368 >3OFT-A nrPDB Length = 396 Score = 35.4 bits (80), Expect = 0.057, Method: Compositional matrix adjust. Identities = 44/170 (25%), Positives = 61/170 (35%), Gaps = 31/170 (18%) Query: 282 FTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQD 341 +T++ +LL G +T + + L L +HPE ++E + + Sbjct: 219 WTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPDLI----------- 267 Query: 342 RGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLH--DNK 399 A E+ R + S DV I KG L L SVLH D Sbjct: 268 -------PAAADELMRRYPTVAVS--RNAVADVDADGVTIRKGD--LVYLPSVLHNLDPA 316 Query: 400 EFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFL 449 F PE D G + G CVG GLARME+ +FL Sbjct: 317 SFEAPEEVR----FDRGLAPIRHTTM---GVGAHRCVGAGLARMEVIVFL 359 >2NZA-A nrPDB Length = 413 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 34/84 (40%), Gaps = 9/84 (10%) Query: 373 DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK 432 DV+ I G + S + D FP+P+ D LD + N + + G Sbjct: 303 DVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRID----LD-----RDPNPHLAYGNGH 353 Query: 433 RICVGEGLARMELFLFLTFILQNF 456 C G LARM+ L + +L+ Sbjct: 354 HFCTGAVLARMQTELLVDTLLERL 377 >5HDI-A nrPDB Length = 404 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 42/186 (22%), Positives = 68/186 (36%), Gaps = 33/186 (17%) Query: 282 FTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQD 341 T + +++T L AG E+T+ L A+ +L P++ +V+ E + Sbjct: 232 LTAQVMMVT---LFAAGGESTAALLGSAVWILATRPDIQQQVRANPELL----------- 277 Query: 342 RGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF 401 A + E RY H V +P + +L + D +F Sbjct: 278 -------GAFIEETLRYEPPFRGHYRH-VRNATTLDGTELPADSHLLLLWGAANRDPAQF 329 Query: 402 PNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSL 461 P F LD G + F G CVG LAR+E + L +L S+ Sbjct: 330 EAPGEFR----LDRAGG----KGHISFGKGAHFCVGAALARLEARIVLRLLLDR---TSV 378 Query: 462 IDPKDL 467 I+ D+ Sbjct: 379 IEAADV 384 >3RWL-A nrPDB Length = 426 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 42/189 (22%), Positives = 74/189 (39%), Gaps = 33/189 (17%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 L+ G +TT ++ +L L K+P+ AK++ +P + + +V Sbjct: 262 LIVGGNDTTRNSMTGGVLALHKNPDQFAKLKA----------NPAL--------VETMVP 303 Query: 354 EVQRYIDLIPTSLPH---AVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 410 E+ R+ T L H D + I KG ++ S D++ PE F Sbjct: 304 EIIRW----QTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEF--- 356 Query: 411 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTT 470 +D + + F G CVG LA M+L + IL F+ ++ + + Sbjct: 357 -IIDR----PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERVRS 411 Query: 471 PVVNGFASV 479 V G+A + Sbjct: 412 NFVRGYAKM 420 >4Z5Q-A nrPDB Length = 423 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 42/199 (21%), Positives = 80/199 (40%), Gaps = 32/199 (16%) Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 PRD + LI+ ++ ++ +E + L I+ +L G ETT++ + + +L + E Sbjct: 229 EPRDDLTSALIEA-RDAHDRLAEPELIGLCIS---ILIGGFETTASEISSFVHVLQQRRE 284 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSL-PHAVTCDVKFR 377 + ++ + E + A V E+ R++ + P D+ Sbjct: 285 LWTRLCADPEAI------------------PAAVEELLRFVPFAANGISPRYALEDMTVG 326 Query: 378 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437 L+ +G ++ ++V D F N DE + N M F G C+G Sbjct: 327 GVLVREGEPVIVDTSAVNRDGLVFDN---------ADEVVIDRADNRHMVFGHGAHHCLG 377 Query: 438 EGLARMELFLFLTFILQNF 456 LAR+EL L +++ Sbjct: 378 AHLARVELQEALKALVEGM 396 >3IVY-A nrPDB Length = 433 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 47/221 (21%), Positives = 80/221 (36%), Gaps = 53/221 (23%) Query: 267 FLIKMEKEKQNQQSEFTIENLVITAAD---------------LLGAGTETTSTTLRYALL 311 + +KM +EK ++ + L+ D L AG ETT ++ ++ Sbjct: 223 YAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMM 282 Query: 312 LLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVT 371 +HP+ Q E+ + V P T A E+ R+ + T+ Sbjct: 283 AFAEHPD-----QWELYKKV-------------RPETAA--DEIVRWATPV-TAFQRTAL 321 Query: 372 CDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMF----DPRHFLDEGGNFKKSNYFMP 427 D + I KG ++ S D + F +P F +P + GG Sbjct: 322 RDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGT--------- 372 Query: 428 FSAGKRICVGEGLARMELFLFLTFILQNF-NLKSLIDPKDL 467 G C+G LARM + L + + +LK + P+ L Sbjct: 373 ---GAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERL 410 >1EHE-A nrPDB Length = 403 Score = 32.7 bits (73), Expect = 0.33, Method: Compositional matrix adjust. Identities = 40/181 (22%), Positives = 71/181 (39%), Gaps = 28/181 (15%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 LL AG T + + L +HP+ A+++ +P + + V Sbjct: 236 LLVAGNATMVNMIALGVATLAQHPDQLAQLKA----------NPSLAPQ--------FVE 277 Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD-PRHF 412 E+ RY ++ DV + L+ I+ S S D + F NP+ F+ R + Sbjct: 278 ELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKW 337 Query: 413 LDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF-NLKSLIDPKDLDTTP 471 + + F G C+ E LA+ EL + + Q F +LK + ++ TP Sbjct: 338 PPQDP--------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTP 389 Query: 472 V 472 + Sbjct: 390 L 390 >4C9K-A nrPDB Length = 421 Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 67/170 (39%), Gaps = 36/170 (21%) Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359 +T L + ++ L +HPE A+++ R P RG V E+ R Sbjct: 259 DTVVNFLGFMMIYLSRHPETVAEMR----------REPLKLQRG--------VEELFRRF 300 Query: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLH--DNKEFPNPEMFDPRHFLDEGG 417 ++ S V D++F ++ +G IL L + LH D++ +P D Sbjct: 301 AVV--SDARYVVSDMEFHGTMLKEGDLIL--LPTALHGLDDRHHDDPMTVD--------- 347 Query: 418 NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQ---NFNLKSLIDP 464 ++ F+ G C G LAR+E+ + L L F LK P Sbjct: 348 LSRRDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVP 397 >3NV6-A nrPDB Length = 452 Score = 32.0 bits (71), Expect = 0.67, Method: Compositional matrix adjust. Identities = 38/155 (24%), Positives = 64/155 (41%), Gaps = 29/155 (18%) Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359 +T L + ++ L +HPE+ A+++ + P RG E+ R Sbjct: 293 DTVVNFLSFFMIHLARHPELVAELRSD----------PLKLMRG--------AEEMFRRF 334 Query: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419 ++ S V D +++ + +G IL L + LH + NPE + LD Sbjct: 335 PVV--SEARMVAKDQEYKGVFLKRGDMIL--LPTALHGLDDAANPEPWK----LDFS--- 383 Query: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQ 454 ++S F G C G LARME+ + L L+ Sbjct: 384 RRSISHSTFGGGPHRCAGMHLARMEVIVTLEEWLK 418 >1F4U-A nrPDB Length = 368 Score = 32.0 bits (71), Expect = 0.69, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 78/201 (38%), Gaps = 25/201 (12%) Query: 287 LVITAADLLGAGTETTSTT----------LRYALLLLLKHPEVTAKVQEEIERVVGRNRS 336 L+ D L +GTE S L Y +LLL+ E T + V+ R Sbjct: 171 LIGYVKDHLNSGTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLISN--SVIDFTRF 228 Query: 337 PCMQD-RGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 Q R Y A+ E RY + ++ VK + I +G + + S Sbjct: 229 NLWQRIREENLYLKAI-EEALRYSPPVMRTV-RKTKERVKLGDQTIEEGEYVRVWIASAN 286 Query: 396 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN 455 D + F + E F P + N + F +G +C+G LAR+E + + + Sbjct: 287 RDEEVFHDGEKFIPD---------RNPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKR 337 Query: 456 FNLKSLIDPKDLDTTPVVNGF 476 F ++D + + V+NG+ Sbjct: 338 FRHIEILDTEKV-PNEVLNGY 357 >2UUQ-A nrPDB Length = 414 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 37/94 (39%), Gaps = 18/94 (19%) Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEMFD----PRHFLDEGGNF 419 L T DV + IP G +L S D +++ P+ D PR+ L Sbjct: 299 GLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPRNILT----- 353 Query: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFIL 453 FS G C+G ARM+ + LT +L Sbjct: 354 --------FSHGAHHCLGAAAARMQCRVALTELL 379 >2QBO-A nrPDB Length = 421 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 37/157 (23%), Positives = 56/157 (35%), Gaps = 31/157 (19%) Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 LL G +T L +++ L K PE ++ E ER+ A Sbjct: 246 LLVVGLDTVVNFLSFSMEFLAKSPEHRQELIERPERI------------------PAACE 287 Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413 E+ R L+ +T D +F + KG IL D +E P D Sbjct: 288 ELLRRFSLVADG--RILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHVD----- 340 Query: 414 DEGGNFKKSNY-FMPFSAGKRICVGEGLARMELFLFL 449 F + F G +C+G+ LAR E+ + L Sbjct: 341 -----FSRQKVSHTTFGHGSHLCLGQHLARREIIVTL 372 >4DJD-D nrPDB Length = 323 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 32/58 (55%), Gaps = 10/58 (17%) Query: 277 NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRN 334 +++E I +TA LL AG A +LL++HPE A+V+E I++++ N Sbjct: 274 GKETERGILWEAVTATALLQAG----------AHILLMRHPEAVARVKENIDQLMVSN 321 >6DXS-A nrPDB Length = 342 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 28/62 (45%), Gaps = 4/62 (6%) Query: 208 VSTPWIQICNNF-PTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDC 266 V+ PW Q CNN ++D FP T + E+D+ + E + + N FI C Sbjct: 83 VAVPWAQACNNLIARVVDLFPETFAGVCMLPQSPEADMTSSIAELERCV---NELGFIGC 139 Query: 267 FL 268 L Sbjct: 140 NL 141 >1PIO-A nrPDB Length = 257 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 37/80 (46%) Query: 113 VFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC 172 + +NGK KE ++F L + N G I+D V ++ + + + T AS D F+ Sbjct: 161 LIANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKVADKSGQSTYASRNDVAFVYPK 220 Query: 173 APCNVICSIIFQKRFDYKDQ 192 I +IF + + D+ Sbjct: 221 GQSEPIVLVIFTNKDNKSDK 240 >3IXQ-A nrPDB Length = 226 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 16/130 (12%) Query: 184 QKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESD 243 +K DY +F+ L+++ S ++ FP ++ P + +++ L+ M + Sbjct: 106 EKIVDYNANEFVVLVDE--------SKLVKKLGEKFPIPVEVIPSAYRVVIRALSEMGGE 157 Query: 244 ILEKVKEHQESMDI-NNPRDFIDCFL-----IKMEKEKQNQQSEFTIENLVITAADLLGA 297 + ++ + + I +N ID F+ I++EKE N +EN + T D + Sbjct: 158 AVIRLGDRKRGPVITDNGNMIIDVFMNIDDAIELEKEINNIPG--VVENGIFTKVDKVLV 215 Query: 298 GTETTSTTLR 307 GT+ TL+ Sbjct: 216 GTKKGVKTLK 225 >3Q5X-A nrPDB Length = 245 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 11/55 (20%) Query: 350 AVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404 AV+H + D++P LP TC K T L + T+V+H+ EF NP Sbjct: 133 AVLHALN---DMVPCYLPPYSTC--------FEKNITFLDAATNVVHELPEFHNP 176 >4CQI-A nrPDB Length = 127 Score = 28.9 bits (63), Expect = 5.4, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 3/83 (3%) Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364 TLR + L + + + E+ER + R + C D +P VV E Q ++P Sbjct: 27 TLRIKVSALKRTIKDLEFAKREVERELQRLDTLCQSDPDRVPQQTKVVDEAQM---MVPH 83 Query: 365 SLPHAVTCDVKFRNYLIPKGTTI 387 S+ + +YL +G+T+ Sbjct: 84 SVNRIMASVKDLSDYLEKEGSTV 106 >5A01-A nrPDB Length = 710 Score = 28.5 bits (62), Expect = 7.4, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 57/133 (42%), Gaps = 22/133 (16%) Query: 212 WIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKM 271 W++I N P + + LL+ A E +I + V + S D R K Sbjct: 532 WVEILKNVPKSVLW-------LLRFPAVGEQNIKKTVSDFGISPD----RVIFSNVAAKE 580 Query: 272 EKEKQNQQSEFTIE----NLVITAADLLGAGT-------ETTSTTLRYALLLLLKHPEVT 320 E ++ Q ++ ++ N T+ D+L GT ET ++ + + L L PE+ Sbjct: 581 EHVRRGQLADICLDTPLCNGHTTSMDVLWTGTPVVTLPGETLASRVAASQLATLGCPELI 640 Query: 321 AKVQEEIERVVGR 333 A+ +EE + + R Sbjct: 641 ARTREEYQNIAIR 653 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4GQS-A nrPDB 660 0.0 5W0C-A nrPDB 646 0.0 2NNH-A nrPDB 634 0.0 1N6B-A nrPDB 618 e-177 3E6I-A nrPDB 568 e-162 4H1N-A nrPDB 567 e-162 2PG7-A nrPDB 546 e-156 3IBD-A nrPDB 540 e-154 5E0E-A nrPDB 536 e-153 5E58-A nrPDB 521 e-148 6B82-A nrPDB 439 e-123 3TBG-A nrPDB 433 e-121 6DWN-A nrPDB 425 e-119 3DL9-A nrPDB 417 e-117 4R20-A nrPDB 411 e-115 2HI4-A nrPDB 401 e-112 5UYS-A nrPDB 396 e-110 4R1Z-A nrPDB 385 e-107 5VBU-A nrPDB 374 e-104 6IQ5-A nrPDB 368 e-102 3QZ1-A nrPDB 358 2e-99 5YLW-A nrPDB 350 7e-97 6DA2-A nrPDB 346 1e-95 6AYB-A nrPDB 337 1e-92 5VEU-A nrPDB 335 4e-92 3K9V-A nrPDB 294 7e-80 3L4D-A nrPDB 293 9e-80 3MDV-A nrPDB 278 4e-75 2WX2-A nrPDB 265 3e-71 2X2N-A nrPDB 246 1e-65 3JUS-A nrPDB 235 3e-62 2W0A-A nrPDB 224 5e-59 5FSA-A nrPDB 224 9e-59 5L1U-A nrPDB 221 5e-58 6C94-A nrPDB 221 6e-58 2Y5N-A nrPDB 219 3e-57 2VZM-A nrPDB 218 3e-57 4WMZ-A nrPDB 218 3e-57 5JLC-A nrPDB 218 4e-57 3EJB-B nrPDB 218 7e-57 5VWS-A nrPDB 217 9e-57 3EL3-A nrPDB 216 2e-56 6CR2-A nrPDB 214 7e-56 5CJE-A nrPDB 209 2e-54 3A50-A nrPDB 208 5e-54 2VE3-A nrPDB 206 1e-53 3N9Z-A nrPDB 206 1e-53 1Z8P-A nrPDB 205 4e-53 6A7J-A nrPDB 203 1e-52 5L94-A nrPDB 203 1e-52 4OQS-A nrPDB 203 1e-52 2ZBZ-A nrPDB 202 3e-52 4OQR-A nrPDB 202 3e-52 3MZS-A nrPDB 200 1e-51 4UBS-A nrPDB 199 3e-51 4Z5P-A nrPDB 198 4e-51 4WPZ-A nrPDB 197 1e-50 6A7I-A nrPDB 196 2e-50 5EX6-C nrPDB 195 4e-50 2Z36-A nrPDB 194 6e-50 4KPA-A nrPDB 193 1e-49 3WVS-A nrPDB 193 2e-49 3ABB-A nrPDB 193 2e-49 5IT1-A nrPDB 190 9e-49 4RM4-A nrPDB 189 3e-48 4YZR-A nrPDB 188 4e-48 5Y1I-A nrPDB 187 1e-47 6FSH-A nrPDB 187 1e-47 3SN5-A nrPDB 186 3e-47 4GGV-A nrPDB 185 4e-47 6GMF-A nrPDB 184 5e-47 5FOI-A nrPDB 184 6e-47 5YSW-A nrPDB 184 6e-47 4MM0-A nrPDB 183 1e-46 1ODO-A nrPDB 183 1e-46 6GK6-A nrPDB 183 1e-46 1GWI-A nrPDB 183 1e-46 5XW2-A nrPDB 183 2e-46 3R9C-A nrPDB 183 2e-46 1LG9-A nrPDB 183 2e-46 4TX3-A nrPDB 182 2e-46 3TYW-A nrPDB 181 8e-46 5NWS-A nrPDB 180 1e-45 6M7X-A nrPDB 179 3e-45 4TRI-A nrPDB 178 6e-45 3MGX-A nrPDB 176 1e-44 4ZGX-A nrPDB 176 3e-44 3P3Z-A nrPDB 173 1e-43 6M7L-A nrPDB 173 2e-43 1CPT-A nrPDB 172 3e-43 3S79-A nrPDB 171 8e-43 6B11-A nrPDB 169 2e-42 2XKR-A nrPDB 169 3e-42 5Z9I-A nrPDB 167 9e-42 3TKT-A nrPDB 167 1e-41 5HH3-A nrPDB 166 2e-41 3OO3-A nrPDB 165 4e-41 6F0B-A nrPDB 164 7e-41 2FR7-A nrPDB 161 8e-40 3A1L-A nrPDB 161 9e-40 5LIV-A nrPDB 155 4e-38 6F88-A nrPDB 155 5e-38 1UE8-A nrPDB 150 1e-36 1Q5D-A nrPDB 150 2e-36 5EX8-A nrPDB 149 3e-36 2RFC-A nrPDB 147 7e-36 6GII-A nrPDB 139 2e-33 1WIY-A nrPDB 130 2e-30 2IJ7-A nrPDB 127 1e-29 2IAG-A nrPDB 124 7e-29 6FYJ-A nrPDB 109 2e-24 5YHJ-A nrPDB 100 1e-21 Sequences not found previously or not previously below threshold: 3ABA-A nrPDB 187 9e-48 4JBT-A nrPDB 182 3e-46 5LIE-A nrPDB 176 2e-44 5OFQ-A nrPDB 176 2e-44 4Z5Q-A nrPDB 174 6e-44 1UED-A nrPDB 170 1e-42 2WIO-A nrPDB 169 2e-42 5GWE-A nrPDB 169 2e-42 5XJN-A nrPDB 169 3e-42 4XE3-A nrPDB 168 5e-42 1EHE-A nrPDB 168 5e-42 3NC3-A nrPDB 167 1e-41 5DE9-A nrPDB 162 3e-40 6HQG-A nrPDB 159 3e-39 5XNT-A nrPDB 159 3e-39 4YT3-A nrPDB 155 3e-38 2WM5-A nrPDB 155 5e-38 4DO1-A nrPDB 153 1e-37 1F4U-A nrPDB 153 2e-37 3RWL-A nrPDB 151 7e-37 2NZA-A nrPDB 150 9e-37 2X9P-A nrPDB 149 3e-36 5FYF-A nrPDB 148 5e-36 6CVC-A nrPDB 146 2e-35 6HQW-A nrPDB 145 5e-35 5DQN-A nrPDB 141 7e-34 4PWV-A nrPDB 140 1e-33 5HIW-A nrPDB 139 2e-33 5HDI-A nrPDB 139 3e-33 5H1Z-A nrPDB 135 5e-32 3IVY-A nrPDB 135 5e-32 2UUQ-A nrPDB 134 1e-31 6DCD-A nrPDB 131 6e-31 6G5O-A nrPDB 131 8e-31 3WEC-A nrPDB 128 5e-30 6HQD-A nrPDB 127 9e-30 6BLD-A nrPDB 125 4e-29 6G71-A nrPDB 124 6e-29 2WIY-A nrPDB 122 3e-28 4FB2-A nrPDB 120 1e-27 3BUJ-A nrPDB 120 1e-27 3B98-A nrPDB 118 5e-27 5D3U-A nrPDB 118 6e-27 3OFT-A nrPDB 117 9e-27 2QBO-A nrPDB 109 3e-24 5OMS-A nrPDB 108 6e-24 5KYO-A nrPDB 103 2e-22 3NV6-A nrPDB 96 4e-20 2ZQJ-A nrPDB 92 4e-19 4C9K-A nrPDB 89 3e-18 5M0P-A nrPDB 88 8e-18 3AWQ-A nrPDB 86 3e-17 2RCM-A nrPDB 77 1e-14 3DBM-A nrPDB 67 1e-11 2YJN-B nrPDB 59 4e-09 4YXC-B nrPDB 33 0.32 4DJD-D nrPDB 32 0.65 4YXB-D nrPDB 31 0.99 3GFZ-A nrPDB 31 1.4 6CNF-R nrPDB 31 1.5 1QN4-A nrPDB 30 2.4 3RFT-A nrPDB 30 2.5 4HE8-H nrPDB 30 3.0 5J1I-A nrPDB 29 3.7 5C8J-I nrPDB 29 5.3 6FEC-u nrPDB 28 9.1 5ZHI-A nrPDB 28 9.4 5L9W-B nrPDB 28 9.9 >4GQS-A nrPDB Length = 477 Score = 660 bits (1704), Expect = 0.0, Method: Composition-based stats. Identities = 465/473 (98%), Positives = 470/473 (99%), Gaps = 1/473 (0%) Query: 19 IWRQSSG-RGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 77 + +++S RGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 60 Query: 78 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 137 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG Sbjct: 61 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 120 Query: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNL 197 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNL Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNL 180 Query: 198 MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDI 257 MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDI Sbjct: 181 MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDI 240 Query: 258 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 317 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP Sbjct: 241 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 300 Query: 318 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 377 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR Sbjct: 301 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 360 Query: 378 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG Sbjct: 361 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 420 Query: 438 EGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV 490 EGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP+ Sbjct: 421 EGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPI 473 >5W0C-A nrPDB Length = 477 Score = 646 bits (1667), Expect = 0.0, Method: Composition-based stats. Identities = 425/473 (89%), Positives = 449/473 (94%), Gaps = 1/473 (0%) Query: 19 IWRQSSG-RGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 77 + +++S RGKLPPGPTPLPVIGNILQI IKD+SKSLTNLSK+YGPVFTLYFGL+ +VVL Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 60 Query: 78 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 137 HGYE VKEALIDLGEEFSGRG FPLAERANRGFGIVFSNGK+WKEIRRFSLMTLRNFGMG Sbjct: 61 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 120 Query: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNL 197 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF KRFDYKDQQFLNL Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNL 180 Query: 198 MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDI 257 MEKLNENI+I+S+PWIQICNNF IIDYFPGTHNKLLKN+AFM+S ILEKVKEHQESMD+ Sbjct: 181 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDM 240 Query: 258 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 317 NNP+DFIDCFL+KMEKEK NQ SEFTIE+L TA DL GAGTETTSTTLRYALLLLLKHP Sbjct: 241 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 300 Query: 318 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 377 EVTAKVQEEIERV+GRNRSPCMQDR HMPYTDAVVHEVQRYIDL+PTSLPHAVTCD+KFR Sbjct: 301 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 360 Query: 378 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 437 NYLIPKGTTIL SLTSVLHDNKEFPNPEMFDP HFLDEGGNFKKS YFMPFSAGKRICVG Sbjct: 361 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 420 Query: 438 EGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV 490 E LA MELFLFLT ILQNFNLKSL+DPK+LDTTPVVNGFASVPPFYQLCFIP+ Sbjct: 421 EALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPI 473 >2NNH-A nrPDB Length = 476 Score = 634 bits (1636), Expect = 0.0, Method: Composition-based stats. Identities = 365/472 (77%), Positives = 415/472 (87%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGPTPLP+IGN+LQID+KD+ KS TN SK+YGPVFT+YFG+ +VV H Sbjct: 1 MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 GYE VKEALID GEEFSGRG+ P+++R +G GI+ SNGKRWKEIRRFSL TLRNFGMGK Sbjct: 61 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 RSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCNVICS++FQKRFDYKDQ FL LM Sbjct: 121 RSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLM 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 ++ NEN RI+++PWIQ+CNNFP +ID FPGTHNK+LKN+A S I EKVKEHQ S+D+N Sbjct: 181 KRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVN 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NPRDFIDCFLIKME+EK NQ+SEF IENLV T ADL AGTETTSTTLRY LLLLLKHPE Sbjct: 241 NPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE 300 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 VTAKVQEEI+ V+GR+RSPCMQDR HMPYTDAVVHE+QRY DL+PT +PHAVT D KFRN Sbjct: 301 VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRN 360 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 YLIPKGTTI+ LTSVLHD+KEFPNP +FDP HFLD+ GNFKKS+YFMPFSAGKRIC GE Sbjct: 361 YLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGE 420 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV 490 GLARMELFLFLT ILQNFNLKS+ D K+L+TT V G S+PP YQ+CFIPV Sbjct: 421 GLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV 472 >1N6B-A nrPDB Length = 473 Score = 618 bits (1594), Expect = e-177, Method: Composition-based stats. Identities = 351/472 (74%), Positives = 412/472 (87%), Gaps = 3/472 (0%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGPTP P+IGNILQID KD+SKSLT S+ YGPVFT+Y G++ VVLH Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 GYE VKEAL+DLGEEF+GRG P+ E+ ++G GI FSN K WKE+RRFSLMTLRNFGMGK Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 RSIEDR+QEEARCLVEELRKT ASPCDPTFILGCAPCNVICS+IF RFDYKD++FL LM Sbjct: 121 RSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 E L+EN+ ++ TPW+Q+ NNFP ++DYFPG H LLKN ++++ I+EKVKEHQ+ +D+N Sbjct: 181 ESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NPRDFIDCFLIKME+E EFT+E+LVI +DL GAGTETTSTTLRY+LLLLLKHPE Sbjct: 241 NPRDFIDCFLIKMEQENNL---EFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPE 297 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 V A+VQEEIERV+GR+RSPCMQDR MPYTDAV+HE+QR+IDL+PT+LPHAVT DV+FRN Sbjct: 298 VAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 357 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 Y IPKGT I+TSLTSVLHD K FPNP++FDP HFLDE GNFKKS+YFMPFSAGKR+CVGE Sbjct: 358 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 417 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV 490 GLARMELFLFLT ILQNF L+SL++PKDLD T VVNGF SVPP YQLCFIP+ Sbjct: 418 GLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIPI 469 >3E6I-A nrPDB Length = 476 Score = 568 bits (1465), Expect = e-162, Method: Composition-based stats. Identities = 272/471 (57%), Positives = 363/471 (77%), Gaps = 1/471 (0%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGP PLP+IGN+ Q+++K++ KS T L++ +GPVFTLY G +RMVV+H Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 GY+ VKEAL+D +EFSGRG P A+R GI+F+NG WK+IRRFSL TLRN+GMGK Sbjct: 61 GYKAVKEALLDYKDEFSGRGDLPAF-HAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 119 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 + E R+Q EA L+E LRKT+ P DPTF++GCAPCNVI I+F+K FDY D++FL LM Sbjct: 120 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 179 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 NEN ++STPW+Q+ NNFP+ + Y PG+H K++KN+A ++ + E+VKEH +S+D N Sbjct: 180 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 239 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 PRD DC L++MEKEK + + +T++ + +T ADL AGTETTSTTLRY LL+L+K+PE Sbjct: 240 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 299 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 + K+ EEI+RV+G +R P ++DR MPY DAVVHE+QR+I L+P++LPH T D FR Sbjct: 300 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 359 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S+YF PFS GKR+C GE Sbjct: 360 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 419 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 GLARMELFL L ILQ+FNLK L+DPKD+D +P+ GF +PP Y+LC IP Sbjct: 420 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 470 >4H1N-A nrPDB Length = 479 Score = 567 bits (1461), Expect = e-162, Method: Composition-based stats. Identities = 241/470 (51%), Positives = 338/470 (71%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGP+PLPV+GN+LQ+D K + +S L + YG VFT+Y G +VVL Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 G + ++EAL+D E FSGRG + + +G+G++F+NG+RW+ +RRFSL T+R+FGMGK Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 RS+E+R+QEEARCLVEELRK+K + D T + N+ICSI+F KRFDYKD FL L+ Sbjct: 121 RSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLL 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 + ++ ++S+ Q+ F + YFPGTH ++ +NL + + I + V++H+ ++D + Sbjct: 181 DLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPS 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 NPRDFID +L++MEK+K + SEF +NL++T L AGTETTSTTLRY LL+LK+P Sbjct: 241 NPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPH 300 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 VT +VQ+EIE+V+G +R P + DR MPYTDAV+HE+QR DLIP +PH VT D +FR Sbjct: 301 VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRG 360 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 Y+IPK T + L+S LHD + F P F+P HFLD G K++ FMPFS GKRIC+GE Sbjct: 361 YVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGE 420 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFI 488 G+AR ELFLF T ILQNF++ S + P+D+D TP +G +VPP YQ+ F+ Sbjct: 421 GIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFL 470 >2PG7-A nrPDB Length = 476 Score = 546 bits (1407), Expect = e-156, Method: Composition-based stats. Identities = 242/471 (51%), Positives = 333/471 (70%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGPTPLP IGN LQ++ + + SL +S+ YGPVFT++ G R+VVL Sbjct: 1 MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 G++ V+EAL+D EEFSGRG + +G+G+VFSNG+R K++RRFS+ TLR+FG+GK Sbjct: 61 GHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 R IE+R+QEEA L++ LR T + DPTF L NVI SI+F RFDYKD++FL+L+ Sbjct: 121 RGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 + + ST Q+ F +++ + PG + + L +E I +KV+ +Q ++D N Sbjct: 181 RMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPN 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 +PRDFID FLI+M++E++N +EF ++NLV+T L GTET STTLRY LLL+KHPE Sbjct: 241 SPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPE 300 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 V AKV EEI+RV+G+NR P +DR MPY +AV+HE+QR+ D+IP SL V D KFR+ Sbjct: 301 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 360 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 + +PKGT + L SVL D F NP+ F+P+HFL+E G FKKS+ F+PFS GKR C GE Sbjct: 361 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGE 420 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 GLARMELFLF T ++QNF LKS PKD+D +P GFA++P Y + F+P Sbjct: 421 GLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLP 471 >3IBD-A nrPDB Length = 476 Score = 540 bits (1392), Expect = e-154, Method: Composition-based stats. Identities = 229/471 (48%), Positives = 327/471 (69%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGP PLP++GN+LQ+D + + KS + YG VFT++ G +V+L Sbjct: 1 MAKKTSSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK 138 G E ++EAL+D E FSGRG + + RG+G++F+NG RWK +RRFS+ T+R+FGMGK Sbjct: 61 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 RS+E+R+QEEA+CL+EELRK+K + DPTF+ N+ICSI+F KRF Y+DQ+FL ++ Sbjct: 121 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 180 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDIN 258 + ++S+ + Q+ F + +FPG H ++ KNL + + I V++H+E++D + Sbjct: 181 NLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 240 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 PRD ID +L+ MEKEK N SEF+ +NL + L AGTETTSTTLRY LL+LK+P Sbjct: 241 APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 300 Query: 319 VTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN 378 V +V EIE+V+G +R P + DR MPYT+AV++E+QR+ DL+P +PH VT FR Sbjct: 301 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 360 Query: 379 YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 Y+IPK T + L++ LHD F P+ F+P HFLD G KK+ F+PFS GKRIC+GE Sbjct: 361 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 420 Query: 439 GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 G+AR ELFLF T ILQNF++ S + P+D+D TP G +PP YQ+ F+P Sbjct: 421 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 471 >5E0E-A nrPDB Length = 463 Score = 536 bits (1381), Expect = e-153, Method: Composition-based stats. Identities = 233/448 (52%), Positives = 321/448 (71%) Query: 41 NILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHF 100 N+LQ+D S + + YG VFT++ G +V+L+G E ++EAL+D E FSGRG Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 101 PLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + E RG+G+VF+NG+RWK +RRFSL+T+R+FGMGKRS+E+R+QEEARCLVEE RK++ Sbjct: 74 AVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQ 133 Query: 161 ASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFP 220 +P DPTF+ C N+ICSI+F +RFDYKD QFL L+ ++ ++S+ Q+ F Sbjct: 134 GAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFS 193 Query: 221 TIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS 280 + YFPGTH ++ +NL + I + V++H+ ++D ++PRDFID +L++MEKEK NQ + Sbjct: 194 GFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 281 EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ 340 EF +NLVI+ L AGTET+STTLRY LL+LK+P V KVQ+EI++V+G +R P ++ Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 341 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400 DR MPYT+AV++E+QR+ DLIP +PH VT D FR YL+PK T + L+S LHD + Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 401 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKS 460 F P+ F+P HFLD G KKS FMPFS GKRIC+GEG+AR ELFLF T ILQNF+L S Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSS 433 Query: 461 LIDPKDLDTTPVVNGFASVPPFYQLCFI 488 + PKD+D +P +GF VP YQ+CF+ Sbjct: 434 PVAPKDIDLSPKESGFGKVPQTYQICFL 461 >5E58-A nrPDB Length = 493 Score = 521 bits (1342), Expect = e-148, Method: Composition-based stats. Identities = 225/449 (50%), Positives = 312/449 (69%), Gaps = 2/449 (0%) Query: 41 NILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHF 100 N+LQ+D S + + YG VFT++ G +V+L+G E ++EAL+D E FSGRG Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 101 PLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + + +G++FSNG+RWK +RRFSL T+R+FGMGKRS+EDR+QEEA+CLVEEL+K++ Sbjct: 102 AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQ 161 Query: 161 ASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFP 220 +P DPTF+ C N+ICSI+F +R+DYKD+QFL L++ ++S+ Q+ F Sbjct: 162 GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 221 TIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS 280 + YFPG H ++ +NL + + + V++H+ ++D +NPRDFID +L++MEKEK NQ + Sbjct: 222 GFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 281 EFTIENLVITAADLLGAGTETTSTTLR-YALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 EF +NL+I+ L AGTETTSTTL Y LL+LK+P V KVQ+EI++V+G +R P + Sbjct: 282 EFHHQNLLISVLSLFFAGTETTSTTL-RYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTL 340 Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNK 399 +DR MPYTDAV+HE+QR+ DL P PH VT D FR YL+PK T + L+S LHD + Sbjct: 341 EDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQ 400 Query: 400 EFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459 F P F+P HFLD G KKS FMPFS GKRIC+GEG+AR ELFLF T ILQNF++ Sbjct: 401 YFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVS 460 Query: 460 SLIDPKDLDTTPVVNGFASVPPFYQLCFI 488 S + PKD+D +P +G VP YQ+ F+ Sbjct: 461 SSVAPKDIDLSPKESGIGKVPQTYQISFL 489 >6B82-A nrPDB Length = 509 Score = 439 bits (1128), Expect = e-123, Method: Composition-based stats. Identities = 147/491 (29%), Positives = 252/491 (51%), Gaps = 27/491 (5%) Query: 19 IWRQSSGRGK-------------LPPGPTPLPVIGNILQIDIKDV-SKSLTNLSKIYGPV 64 + +++S +GK PP LP+IG+++ + +L K YG + Sbjct: 1 MAKKTSSKGKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDL 60 Query: 65 FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR-GFGIVFSN-GKRWKE 122 ++L G ++++++ + KE LI G+ F+GR + R G I F++ WK Sbjct: 61 YSLMMGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKF 120 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 R+ L FG G SIE + EA + E L +++ S D L A NV+C++ Sbjct: 121 HRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALC 180 Query: 183 FQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMES 242 F + D +F ++++ + V+ + + FP + FP ++L+ + Sbjct: 181 FNSSYKRGDAEFESMLQYSQGIVDTVAKDS--LVDIFPW-LQIFPNKDLRILRQCISIRD 237 Query: 243 DILEKV-KEHQESMDINNPRDFIDCFLIKMEKEKQNQQSE----FTIENLVITAADLLGA 297 +L+K +EH+ + N RD +D L + N S T +++++T ++ GA Sbjct: 238 KLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGA 297 Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQR 357 G ETT+TTL++++ L+ +P+V K+QEE++ +G+ R P + DRG++PY +A + EV R Sbjct: 298 GVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMR 357 Query: 358 YIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG 417 + P +PH D Y + KGT ++ ++ S+ HD KE+ NPE+FDP FL+E G Sbjct: 358 IRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEG 417 Query: 418 NFK--KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNG 475 + S ++PF AG R+C+GE LA+MELFLFL +ILQ F L+ + L G Sbjct: 418 DGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTG-QPLPDLQGKFG 476 Query: 476 FASVPPFYQLC 486 P +++ Sbjct: 477 VVLQPKKFKVV 487 >3TBG-A nrPDB Length = 479 Score = 433 bits (1113), Expect = e-121, Method: Composition-based stats. Identities = 194/476 (40%), Positives = 283/476 (59%), Gaps = 7/476 (1%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPPGP PLP +GN+L +D ++ L + +G VF+L +VVL+ Sbjct: 1 MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN 60 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERA---NRGFGIVFSN-GKRWKEIRRFSLMTLRNF 134 G V+EAL+ GE+ + R P+ + R G+ + G W+E RRFS+ TLRN Sbjct: 61 GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL 120 Query: 135 GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQF 194 G+GK+S+E V EEA CL P P +L A NVI S+ +RF+Y D +F Sbjct: 121 GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF 180 Query: 195 LNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQES 254 L L++ E ++ S ++ N P ++ + P K+L+ + + E + EH+ + Sbjct: 181 LRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAFLTQLDELLTEHRMT 239 Query: 255 MDI-NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313 D PRD + FL +MEK K N +S F ENL I ADL AG TTSTTL + LLL+ Sbjct: 240 WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM 299 Query: 314 LKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCD 373 + HP+V +VQ+EI+ V+G+ R P M D+ HMPYT AV+HEVQR+ D++P + H + D Sbjct: 300 ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRD 359 Query: 374 VKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKR 433 ++ + + IPKGTT++T+L+SVL D + P F P HFLD G+F K F+PFSAG+R Sbjct: 360 IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR 419 Query: 434 ICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 C+GE LARMELFLF T +LQ+F+ S+ + + V F P Y+LC +P Sbjct: 420 ACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVP 474 >6DWN-A nrPDB Length = 491 Score = 425 bits (1093), Expect = e-119, Method: Composition-based stats. Identities = 144/471 (30%), Positives = 246/471 (52%), Gaps = 22/471 (4%) Query: 19 IWRQSSGRG-KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 77 + +++S +G K PPGP P+IG++L + K+ +L+ +S+ YG V + G +VVL Sbjct: 1 MAKKTSSKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVL 59 Query: 78 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFG 135 G + +++AL+ G++F GR + G + FS +G W RR + L++F Sbjct: 60 SGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFS 119 Query: 136 MGKRS-------IEDRVQEEARCLVEELRKTKASP--CDPTFILGCAPCNVICSIIFQKR 186 + +E+ V +EA L+ L++ A P +P + + NVIC+I F +R Sbjct: 120 IASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRR 179 Query: 187 FDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILE 246 +D+ Q+ L+L+ N +V + +F I+ Y P K+L ++ Sbjct: 180 YDHNHQELLSLVNLNNNFGEVVGSG---NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQ 236 Query: 247 K-VKEHQESMDINNPRDFIDCFLIKMEKE--KQNQQSEFTIENLVITAADLLGAGTETTS 303 K VKEH ++ + + RD D + +++ +N + + E ++ DL GAG +T + Sbjct: 237 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVT 296 Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIP 363 T + ++L+ L+ +P V K+QEE++ V+GR+R P + DR H+PY +A + E R+ +P Sbjct: 297 TAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP 356 Query: 364 TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK-- 421 ++PH+ T D + + IPKG + + + HD K + NP F P FL G K Sbjct: 357 FTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVL 416 Query: 422 SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472 S + F GKR C+GE +AR E+FLFL +LQ S+ +D TP+ Sbjct: 417 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF-SVPLGVKVDMTPI 466 >3DL9-A nrPDB Length = 479 Score = 417 bits (1072), Expect = e-117, Method: Composition-based stats. Identities = 156/438 (35%), Positives = 250/438 (57%), Gaps = 3/438 (0%) Query: 50 VSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRG 109 + S++YG +F+L G VVL+GY+VVKE L+ E F+ R PL + + Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 110 FGIVFSN-GKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTF 168 G++ S G+ W + RR ++ + R FG G++S E ++ EE + + + K P D Sbjct: 96 GGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQ 155 Query: 169 ILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG 228 ++ A N+ IIF +RF Y+D F +++E +EN+ + ++ + + N FP I G Sbjct: 156 LITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFG 215 Query: 229 THNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLV 288 H +L +N A + + +++ + P+ F+D +L +M++ K + S F+ ENL+ Sbjct: 216 KHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLI 275 Query: 289 ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT 348 + +L+ AGTETT+ LR+A+L + +P + +VQ+EI+ ++G N P D+ MPYT Sbjct: 276 FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYT 335 Query: 349 DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD 408 +AV+HEV R+ +++P + HA + D R Y IPKGTT++T+L SV D K + +PE+F Sbjct: 336 EAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 395 Query: 409 PRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLD 468 P FLD G F K +PFS G+R C+GE LARME+FLF T +LQ F+L D Sbjct: 396 PERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL-HFPHELVPD 454 Query: 469 TTPVVNGFASVPPFYQLC 486 P + G P Y +C Sbjct: 455 LKPRL-GMTLQPQPYLIC 471 >4R20-A nrPDB Length = 486 Score = 411 bits (1056), Expect = e-115, Method: Composition-based stats. Identities = 152/483 (31%), Positives = 242/483 (50%), Gaps = 17/483 (3%) Query: 19 IWRQSSGRGKLPPGPTP--LPVIGNILQIDIKD-------VSKSLTNLSKIYGPVFTLYF 69 + +++S +GK G + P + + + T LS YGP+F LY Sbjct: 1 MAKKTSSKGKEGVGSSSVSFPCLPRLPLLGSLLHLRSNLPPHLLFTQLSSQYGPLFGLYA 60 Query: 70 GLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRG-FGIVFSN-GKRWKEIRRFS 127 G +V+ +V+E L+ G EF+GR + +G I F++ WK RR Sbjct: 61 GPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDIAFADYSPLWKNHRRLV 120 Query: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRF 187 + FG G ++ VQE A L EEL+ + D + +L A NVIC ++F + Sbjct: 121 HSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSSSY 180 Query: 188 DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDIL-E 246 D + +++ + ++ ++ + + FP + FP K LK + +L + Sbjct: 181 QPSDPELQTVIQYNDGIVQTIARG--GLVDIFPW-LRIFPNKDLKRLKECVSIRDQLLYK 237 Query: 247 KVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTL 306 K+ EH++S+ PRD +D LI ++ + T +++++TAA+ GAG ETTSTTL Sbjct: 238 KLLEHKKSLTPGEPRDLLDALLIGQQRGSGGA-DDITEDHVLMTAAEAFGAGVETTSTTL 296 Query: 307 RYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSL 366 + + LL HP++ +VQ E++ VG +R PC+ DR H+P DAV+ EV R + P + Sbjct: 297 LWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMRIRPVSPILI 356 Query: 367 PHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFM 426 PH D + +PKGT +L ++ ++ HD K + PE F+P FL+ G K + F+ Sbjct: 357 PHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSGKKKTQSSFL 416 Query: 427 PFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLC 486 PF AG R+CVGE LAR+ELFLF++ LQ F+ S L G P Y + Sbjct: 417 PFGAGPRVCVGESLARIELFLFVSRPLQRFSF-SCPSEASLPDLQGRFGVVLQPERYTVT 475 Query: 487 FIP 489 P Sbjct: 476 VTP 478 >2HI4-A nrPDB Length = 495 Score = 401 bits (1031), Expect = e-112, Method: Composition-based stats. Identities = 132/460 (28%), Positives = 223/460 (48%), Gaps = 20/460 (4%) Query: 28 KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 87 K PP P P++G++L + K+ +L+ +S+ YG V + G ++VL + +++AL Sbjct: 16 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 74 Query: 88 IDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMGKRS----- 140 + G++F GR + G + FS +G W RR + L F + Sbjct: 75 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 134 Query: 141 --IEDRVQEEARCLVEELRKTKASP--CDPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 196 +E+ V +EA+ L+ L++ A P DP + + NVI ++ F + F + L+ Sbjct: 135 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 194 Query: 197 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESM 255 L++ +E + S+ + FP I+ Y P + K L+K V+EH + Sbjct: 195 LVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 251 Query: 256 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315 D N+ RD +K + + E +V D+ GAG +T +T + ++L+ L+ Sbjct: 252 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 311 Query: 316 HPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 375 PE+ K+Q+E++ V+GR R P + DR +PY +A + E R+ +P ++PH+ T D Sbjct: 312 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 371 Query: 376 FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK---SNYFMPFSAGK 432 + IPK + + V HD + + +P F P FL G S M F GK Sbjct: 372 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 431 Query: 433 RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472 R C+GE LA+ E+FLFL +LQ S+ +D TP+ Sbjct: 432 RRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 470 >5UYS-A nrPDB Length = 494 Score = 396 bits (1017), Expect = e-110, Method: Composition-based stats. Identities = 133/473 (28%), Positives = 236/473 (49%), Gaps = 21/473 (4%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKD-VSKSLTNLSKIYGPVFTLYFGLERMVVL 77 + +++ K P LP++G++ + + + L K YGP++++ G + V++ Sbjct: 1 MAKKTG--AKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIV 58 Query: 78 HGYEVVKEALIDLGEEFSGRGHFPLAERA-NRGFGIVFSN-GKRWKEIRRFSLMTLRNFG 135 +++ KE LI G++FSGR + A N GI F++ G W+ RR ++ T F Sbjct: 59 GHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFK 118 Query: 136 MGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFL 195 G + +E + +E L + L D +F + A NVI I F + D + L Sbjct: 119 DGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-L 177 Query: 196 NLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKE-HQES 254 N+++ NE I + + + P + FP + LK+ + +D+L K+ E ++E Sbjct: 178 NVIQNYNEGIIDNLSKDS-LVDLVPW-LKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 235 Query: 255 MDINNPRDFIDCFLIK-MEKEKQNQQSE-----FTIENLVITAADLLGAGTETTSTTLRY 308 ++ + +D + M + N + + +++ T D+ GAG ETT++ +++ Sbjct: 236 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 295 Query: 309 ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPH 368 L LL +P+V K+ EEI++ VG +R+P + DR + +A + EV R + P +PH Sbjct: 296 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 355 Query: 369 AVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN--FKKSNYFM 426 D + + KGT ++ +L ++ H+ KE+ P+ F P FL+ G S ++ Sbjct: 356 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 415 Query: 427 PFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASV 479 PF AG R C+GE LAR ELFL + ++LQ F+L+ P D P + G V Sbjct: 416 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLE---VPDDGQL-PSLEGIPKV 464 >4R1Z-A nrPDB Length = 439 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 134/427 (31%), Positives = 222/427 (51%), Gaps = 13/427 (3%) Query: 69 FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR-GFGIVFSN-GKRWKEIRRF 126 G ++++++ + KE LI G+ F+GR + R G I F++ WK R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 127 SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKR 186 L FG G SIE + EA + E L +++ S D L A NV+C++ F Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 187 FDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILE 246 + D +F ++++ + V+ + + FP + FP +L+ + +L+ Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKDS--LVDIFPWL-QIFPNKDLTILRQCISIRDKLLQ 177 Query: 247 KV-KEHQESMDINNPRDFIDCFLIKMEKEKQNQQSE----FTIENLVITAADLLGAGTET 301 K +EH+ + N RD +D L + N S T +++++T D+ GAG ET Sbjct: 178 KKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVET 237 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL 361 T+T L++++ L+ +P+V K+QEE++ +G+ R P + DRG++PY +A + EV R + Sbjct: 238 TTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPV 297 Query: 362 IPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK- 420 P +PH D Y + KGT ++ +L S+ HD KE+ NPE+FDP FL+E G+ Sbjct: 298 SPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLC 357 Query: 421 -KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASV 479 S ++PF AG R+C+GE LA+MELFLFL +ILQ F L+ + L G Sbjct: 358 CPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTG-QPLPDLQGKFGVVLQ 416 Query: 480 PPFYQLC 486 P +++ Sbjct: 417 PKKFKVV 423 >5VBU-A nrPDB Length = 476 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 139/486 (28%), Positives = 233/486 (47%), Gaps = 37/486 (7%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 78 + +++S +GKLPP + L + D+ L L++ +GP++ L+ GL+ +VVL+ Sbjct: 1 MAKKTSSKGKLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLN 54 Query: 79 GYEVVKEALIDLGEEFSGRGHFPLAERANRGF-----GIVFSNGKRWKEIRRFSLMTLRN 133 ++EA++ +F+GR + +R + G K K++ R +L+ Sbjct: 55 SKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL---- 110 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQ 193 G+ + S+E V++ + E +R +P C++IC + F + Sbjct: 111 LGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDD--- 166 Query: 194 FLNLMEKLNENIRIVSTPW----IQICNNFPTIIDYFPGTHNKLLKNLAFMESDILE-KV 248 NLM + I+ V W IQI + P + +FP + LK I+E ++ Sbjct: 167 --NLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQL 223 Query: 249 KEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLV-ITAADLLGAGTETTSTTLR 307 ++H+ES+ RD +D L + + + S +E V + A DLL GTETT+ TL Sbjct: 224 RQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLS 283 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRNRS---PCMQDRGHMPYTDAVVHEVQRYIDLIPT 364 +A++ LL HPE+ ++QEE++ +G S +DR +P +A + EV R ++P Sbjct: 284 WAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPL 343 Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424 +LPH T Y IP+GT I+ +L D + P F P FL+ G N + Sbjct: 344 ALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA--- 400 Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP-KDLDTTPVVNGFASVPPFY 483 + F G R+C+GE LAR+ELF+ LT +LQ F L D L P + + P + Sbjct: 401 -LAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQP-F 458 Query: 484 QLCFIP 489 Q+ P Sbjct: 459 QVRLQP 464 >6IQ5-A nrPDB Length = 463 Score = 368 bits (945), Expect = e-102, Method: Composition-based stats. Identities = 141/453 (31%), Positives = 227/453 (50%), Gaps = 23/453 (5%) Query: 51 SKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGF 110 S L++ YG VF + G +VVL+G + +AL+ G F+ R F + G Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 111 GIVFSN-GKRWKEIRRFSLMTLRNF----GMGKRSIEDRVQEEARCLVEELRKTKASPC- 164 + F + + WK RR + +RNF ++ +E V EAR LV L + A Sbjct: 64 SMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAF 123 Query: 165 -DPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTII 223 DP + A NV+ ++ F R+ + D +F L+ E R V + + P + Sbjct: 124 LDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGS--LVDVMPW-L 180 Query: 224 DYFPGTHNKLLKNLAFME----SDILEKVKEHQESMDINN-PRDFIDCFLIKMEK----E 274 YFP + + + + IL+K H ES+ PRD +D F++ EK + Sbjct: 181 QYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGD 240 Query: 275 KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRN 334 + +EN+ T D+ GA +T ST L++ LLL ++P+V +VQ E+++VVGR+ Sbjct: 241 SHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRD 300 Query: 335 RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSV 394 R PCM D+ ++PY A ++E R+ +P ++PHA T + Y IPK T + + SV Sbjct: 301 RLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSV 360 Query: 395 LHDNKEFPNPEMFDPRHFLDEGGNFKK--SNYFMPFSAGKRICVGEGLARMELFLFLTFI 452 HD ++PNPE FDP FLD+ G K ++ M FS GKR C+GE L++M+LFLF++ + Sbjct: 361 NHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISIL 420 Query: 453 LQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQL 485 + + +P + G P +++ Sbjct: 421 AHQCDFR--ANPNEPAKMNFSYGLTIKPKSFKV 451 >3QZ1-A nrPDB Length = 496 Score = 358 bits (920), Expect = 2e-99, Method: Composition-based stats. Identities = 125/446 (28%), Positives = 208/446 (46%), Gaps = 25/446 (5%) Query: 37 PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSG 96 P++ L + ++ L +L++ GPV+ L GL+ +VVL+ ++EA+I +F+G Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 97 RGHFPLAERANR-----GFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS-IEDRVQEEAR 150 R P + ++ G K K++ R +L+ +G RS +E V + + Sbjct: 92 RPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALL------LGTRSSMEPWVDQLTQ 145 Query: 151 CLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVST 210 E +R +P C++IC + F + D F + ++ L + S Sbjct: 146 EFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDHWS- 204 Query: 211 PWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESMDINNPRDFIDCFLI 269 IQI + P + +FP LK ++EK ++ H+ESM RD D L Sbjct: 205 --IQILDMVP-FLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQ 261 Query: 270 KMEKEKQNQQSEFTIENLV-ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIE 328 + +++ + +E V ++ DL GTETT++TL +A+ LL HPE+ ++QEE++ Sbjct: 262 GVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELD 321 Query: 329 RVVGRNRS---PCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGT 385 R +G S +DR +P +A + EV R ++P +LPH T Y IP+G Sbjct: 322 RELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGM 381 Query: 386 TILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 ++ +L D + P F P FL+ G N + F G R+C+GE LAR+EL Sbjct: 382 VVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSA----LAFGCGARVCLGESLARLEL 437 Query: 446 FLFLTFILQNFNLKSLIDPKDLDTTP 471 F+ L +LQ F L P Sbjct: 438 FVVLARLLQAFTLLPPPVGALPSLQP 463 >5YLW-A nrPDB Length = 495 Score = 350 bits (898), Expect = 7e-97, Method: Composition-based stats. Identities = 126/512 (24%), Positives = 224/512 (43%), Gaps = 42/512 (8%) Query: 1 MDPF---VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNL 57 MD F L + + LS R R LPPGP P P++GN+LQ+ + + L Sbjct: 1 MDSFPLLAALFFIAATITFLSFRR----RRNLPPGPFPYPIVGNMLQLGA-NPHQVFAKL 55 Query: 58 SKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRG-----HFPLAERANRGFGI 112 SK YGP+ +++ G V++ E+ KE L G+ FSGR H ++ + GF Sbjct: 56 SKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLP 115 Query: 113 VFSNGKRWKEIRR------FSLMTL-RNFGMGKRSIEDRVQEEARCLVEELRKTKASPCD 165 V S W+++R+ FS ++ + G+ ++ ++ + +C D Sbjct: 116 VASE---WRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKC------SDSGRAVD 166 Query: 166 PTFILGCAPCNVICSIIFQKRF-DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIID 224 N++ + +F + ++ + + E + IV P + FP + Sbjct: 167 IREAAFITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVP--NFADYFPILRP 224 Query: 225 YFPGTHNKLL-----KNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQ 279 + P + K LA +E + E+++ + + + DF++ + + Q + Sbjct: 225 FDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDII----QANE 280 Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 + + DL G++T +T++ +A+ L+ +P+ A+++ E++ V G + Sbjct: 281 FKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDE 340 Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNK 399 +PY AV+ EV R P LP D + YLIPKGT IL + ++ D Sbjct: 341 SAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPS 400 Query: 400 EFPNPEMFDPRHFLDEGGNFKKSNY-FMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 + +PE FDP FLD +FK +Y +PF +G+R+C G LA L + ++ NF+ Sbjct: 401 IWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDW 460 Query: 459 KSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV 490 K D +V L IP+ Sbjct: 461 KLEDDSTAAADHAGELFGVAVRRAVPLRIIPI 492 >6DA2-A nrPDB Length = 487 Score = 346 bits (887), Expect = 1e-95, Method: Composition-based stats. Identities = 114/444 (25%), Positives = 178/444 (40%), Gaps = 29/444 (6%) Query: 31 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID- 89 PGPTPLP +GNIL K K YG V+ Y G + ++ + +++K L+ Sbjct: 19 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 77 Query: 90 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 148 F+ R P I + + WK +R + F GK + + + + Sbjct: 78 CYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRLRS---LLSPTFTSGKLKEMVPIIAQY 132 Query: 149 ARCLVEELRKTK--ASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIR 206 LV LR+ P + G +VI S F D + +E + +R Sbjct: 133 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 192 Query: 207 I-VSTPWIQICNNFPTIID--------YFP-GTHNKLLKNLAFMESDILEKVKEHQESMD 256 P+ FP +I FP N L K++ M+ LE ++H+ Sbjct: 193 FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV--- 249 Query: 257 INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKH 316 DF+ + ++ + LV + + AG ETTS+ L + + L H Sbjct: 250 -----DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 304 Query: 317 PEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF 376 P+V K+QEEI+ V+ P M Y D VV+E R + L DV+ Sbjct: 305 PDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR-LERVCKKDVEI 363 Query: 377 RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICV 436 IPKG ++ ++ D K + PE F P F + + + PF +G R C+ Sbjct: 364 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI 423 Query: 437 GEGLARMELFLFLTFILQNFNLKS 460 G A M + L L +LQNF+ K Sbjct: 424 GMRFALMNMKLALIRVLQNFSFKP 447 >6AYB-A nrPDB Length = 466 Score = 337 bits (863), Expect = 1e-92, Method: Composition-based stats. Identities = 105/475 (22%), Positives = 200/475 (42%), Gaps = 36/475 (7%) Query: 19 IWRQSSGRGKLPPG-PTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 77 + +++S +GKLPP P +P +G+ + K+ + + + SK YG VFT + M L Sbjct: 1 MAKKTSSKGKLPPRVPNLIPYVGSFVSF-AKNPVQFIIDNSKKYGDVFTATILGKEMTFL 59 Query: 78 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG--KRWKEIRRF--SLMTLRN 133 + +++ E S R + G G+V+ +R E +F S +T Sbjct: 60 NHPKILDTFFKATDNELSLRDVYRFMRPVF-GTGVVYDADSTERMMEQVKFVSSGLTTAR 118 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQ 193 F + ED + + + L E A I + C + + +Q Sbjct: 119 FRVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASRCLLGDEV----------RQ 168 Query: 194 FLNL--MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKE- 250 +L+ + KL +I +P + P +K K + + ++L+K +E Sbjct: 169 YLSEKNLGKLYHDIDDGISPLSFFYPSLPA------PKRDKARKAVGEIFQELLDKRREE 222 Query: 251 ---HQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 H E + + D +D L + K+ Q E T + + L AG T+S T Sbjct: 223 HKKHPERLLDESKMDVVDHLLTQKYKDGQ----ELTDVHRIGILIAGLFAGQHTSSITSS 278 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP 367 + L+ ++ + +V KV++E E ++G ++ M Y +A + E R + + Sbjct: 279 WTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPL-IMIM 337 Query: 368 HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMP 427 + Y+IPKG ++ S + + NP++FDP + + K +P Sbjct: 338 RMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVP 397 Query: 428 FSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPF 482 F AG+ C+GE A +++ ++ +L+ F+++ + D T +V G + PP Sbjct: 398 FGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPDPSYTSLVVGPS--PPT 450 >5VEU-A nrPDB Length = 480 Score = 335 bits (858), Expect = 4e-92, Method: Composition-based stats. Identities = 109/436 (25%), Positives = 178/436 (40%), Gaps = 14/436 (3%) Query: 31 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID- 89 PGPTPLP++GN+L + + K T K YG ++ Y G ++ + +V++ L+ Sbjct: 18 PGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 76 Query: 90 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 148 F+ R L I + + WK IR + F GK + + + + Sbjct: 77 CYSVFTNRRS--LGPVGFMKSAISLAEDEEWKRIRS---LLSPTFTSGKLKEMFPIIAQY 131 Query: 149 ARCLVEELRKT--KASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIR 206 LV LR+ K P I G +VI F D + +E + ++ Sbjct: 132 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 191 Query: 207 I-VSTPWIQICNNFPTIIDYFPGTHNKLL-KNLAFMESDILEKVKEHQESMDINNPRDFI 264 P FP + F + L K+ S + ++K+ + + + DF+ Sbjct: 192 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL 251 Query: 265 DCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 + ++ + L + + AG ETTS+ L + L L HP+V K+Q Sbjct: 252 QLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQ 311 Query: 325 EEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 384 +EI+ V+ P M Y D VV+E R + L DV+ IPKG Sbjct: 312 KEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF-PVAIRLERTCKKDVEINGVFIPKG 370 Query: 385 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME 444 + ++ ++ HD K + PE F P F + + + PF G R C+G A M Sbjct: 371 SMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI-DPYIYTPFGTGPRNCIGMRFALMN 429 Query: 445 LFLFLTFILQNFNLKS 460 + L L +LQNF+ K Sbjct: 430 MKLALIRVLQNFSFKP 445 >3K9V-A nrPDB Length = 482 Score = 294 bits (752), Expect = 7e-80, Method: Composition-based stats. Identities = 101/450 (22%), Positives = 185/450 (41%), Gaps = 45/450 (10%) Query: 31 PGPTPLPVIGNILQI----DIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEA 86 PGPT P++G++L+I +K +L K YG +F + G V L + EA Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP-SLLEA 85 Query: 87 LIDLGEEFSGRGHF----PLAERANRGFGIVFSNGKRWKEIRR-FSLMTLRNFGMGKRSI 141 L R + N +G++ G+ W+ +R F ++ + K + Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 143 Query: 142 EDRVQEEARCLVE---ELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLM 198 + ++ E +E EL + D L IC ++++KRF L+ Sbjct: 144 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRF--------GLL 195 Query: 199 EKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV-KEHQESMD- 256 +K E + F T I T K++ + + KV + H + D Sbjct: 196 QKETEEEAL----------TFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDT 245 Query: 257 -INNPRDFIDCFLIKMEKEKQN-------QQSEFTIENLVITAADLLGAGTETTSTTLRY 308 + + ID L + ++ QQ + + L +L A ETT+ +L + Sbjct: 246 IFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMW 305 Query: 309 ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPH 368 L L ++P+ ++ +E++ V+ N++P +D +MPY A + E R +P + Sbjct: 306 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-R 364 Query: 369 AVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPF 428 + Y +PKGT + + + F + F P +L + +PF Sbjct: 365 TLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI-NPFAHLPF 423 Query: 429 SAGKRICVGEGLARMELFLFLTFILQNFNL 458 GKR+C+G LA ++L L L +I+Q +++ Sbjct: 424 GIGKRMCIGRRLAELQLHLALCWIIQKYDI 453 >3L4D-A nrPDB Length = 453 Score = 293 bits (751), Expect = 9e-80, Method: Composition-based stats. Identities = 99/470 (21%), Positives = 181/470 (38%), Gaps = 49/470 (10%) Query: 26 RGKLPP---GPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEV 82 +GKLPP G T P +G+I+Q KD + K YG +FT+ R+ V+ Sbjct: 1 KGKLPPVVHGTT--PFVGHIIQFG-KDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQ 57 Query: 83 VKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG-KRWKEIRRF--SLMTLRNFGMGKR 139 + E S R + G G+ ++ R +E F +T+ F Sbjct: 58 HSKFFTPRNEILSPREVYSFMVPVF-GEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAP 116 Query: 140 SIEDRVQE--EARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQK--RFDYKDQQFL 195 SI+ V++ +A +E C I N C +F + R +QF Sbjct: 117 SIQHEVRKFMKANWNKDEGEINILDDCSAMII------NTACQCLFGEDLRKRLDARQFA 170 Query: 196 NLMEKLNENI--RIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV---KE 250 L+ K+ + V PWI P + ++ DIL ++ +E Sbjct: 171 QLLAKMESCLIPAAVFLPWIL----------KLPLPQSYRCRDARAELQDILSEIIIARE 220 Query: 251 HQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYAL 310 +E+ N D + L + ++ + + + + AG T++ T ++L Sbjct: 221 KEEAQKDTNTSDLLAGLLGAVYRDG----TRMSQHEVCGMIVAAMFAGQHTSTITTTWSL 276 Query: 311 LLLL--KHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPH 368 L L+ ++ AK+ +EI+ + + + MP+ + E R + L Sbjct: 277 LHLMDPRNKRHLAKLHQEIDEFPAQLNYDNVME--EMPFAEQCARESIRRDPPL-VMLMR 333 Query: 369 AVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPF 428 V V+ Y++P+G I S D + FPNP ++P + F F Sbjct: 334 KVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMKLV-----DGAFCGF 388 Query: 429 SAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFAS 478 AG C+GE +++ L +L++++ + L + + +V G + Sbjct: 389 GAGVHKCIGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTA 438 >3MDV-A nrPDB Length = 456 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 88/429 (20%), Positives = 170/429 (39%), Gaps = 26/429 (6%) Query: 44 QIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFP-- 101 ++ + + + +K YGPV + + V++ E VK+ L+ + + Sbjct: 6 EVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQ 65 Query: 102 --LAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT 159 ER + N +RW + RR + + S+ + E+A LVE L Sbjct: 66 TVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNEKAEQLVEILEA- 122 Query: 160 KASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNF 219 KA P + + I+ + F + L + L++ ++++ I + Sbjct: 123 KADGQTPVSMQDMLTYTAM-DILAKAAFGMETSMLLGAQKPLSQAVKLMLEG---ITASR 178 Query: 220 PTIIDYFPGTHNKLLK---NLAFMESDILEKVKEHQESMDINN--PRDFIDCFLIKMEKE 274 T+ + PG +L + ++ F+ + V+ +E++ P D + L E Sbjct: 179 NTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE-- 236 Query: 275 KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRN 334 E L+ AG ET++ L + ++ L + PE+ A++Q E++ V+G Sbjct: 237 -----GAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSK 291 Query: 335 RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSV 394 R +D G + Y V+ E R + + +P T +L S + Sbjct: 292 RYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVM 350 Query: 395 LHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQ 454 + F +P F+P F G K + PFS G R C+G+ A+ME+ + + +LQ Sbjct: 351 GRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 408 Query: 455 NFNLKSLID 463 + + Sbjct: 409 RLEFRLVPG 417 >2WX2-A nrPDB Length = 473 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 92/461 (19%), Positives = 182/461 (39%), Gaps = 42/461 (9%) Query: 30 PP-GPTPLPVIGNILQIDIKDVSKSLTNLSK--IYGPVFTLYFGLERMVVLHGYEVVKEA 86 PP P +P +G+I+Q K+ + + + G VFT+ G +R+ ++ Sbjct: 18 PPVYPVTVPFLGHIVQFG-KNPLEFMQRCKRDLKSG-VFTISIGGQRVTIVGDPHEHSRF 75 Query: 87 LIDLGEEFSGRGHFPLAERANRGFGIVFSNG-KRWKEIRRF--SLMTLRNFGMGKRSIED 143 E S R + + G G+ ++ R +E F +T+ F +I+ Sbjct: 76 FSPRNEILSPREVYTIMTPVF-GEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQH 134 Query: 144 RVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQK--RFDYKDQQFLNLMEKL 201 V+ + + E ++ + + G N C +F + R + F L+ K+ Sbjct: 135 EVR---KFMAENWKEDEG-VINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKM 190 Query: 202 NENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV---KEHQESMDIN 258 ++ F + P + + IL ++ +E +E+ N Sbjct: 191 ESSLI--------PAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDN 242 Query: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK--H 316 N D + L + ++ + ++ + + AG T++ T +++L L+ + Sbjct: 243 NTSDLLGGLLKAVYRDG----TRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKN 298 Query: 317 PEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF 376 + K+ +EI+ + + D MP+ + V E R + + V +VK Sbjct: 299 KKWLDKLHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPL-LMVMRMVKAEVKV 355 Query: 377 RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICV 436 +Y++PKG I S HD + FPNP ++DP + K F+ F AG C+ Sbjct: 356 GSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPER------DEKVDGAFIGFGAGVHKCI 409 Query: 437 GEGLARMELFLFLTFILQNFNLKSLIDP-KDLDTTPVVNGF 476 G+ A +++ L + ++ + L D D D +V G Sbjct: 410 GQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGP 450 >2X2N-A nrPDB Length = 475 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 90/465 (19%), Positives = 174/465 (37%), Gaps = 46/465 (9%) Query: 30 PP-GPTPLPVIGNILQIDIKDVSKSLTNLSKIY-GPVFTLYFGLERMVVLHGYEVVKEAL 87 PP P +P++G+I+Q K + + +FT+ +R+ ++ Sbjct: 18 PPVYPVTVPILGHIIQFG-KSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFF 76 Query: 88 IDLGEEFSGRGHFPLAERANRGFGIVFSNG-KRWKEIRRF--SLMTLRNFGMGKRSIEDR 144 + E S R + G G+ ++ R +E F +T+ F +I+ Sbjct: 77 LPRNEVLSPREVYSFMVPVF-GEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHE 135 Query: 145 VQE--EARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQK--RFDYKDQQFLNLMEK 200 V++ A +E C I N C +F + R ++F L+ K Sbjct: 136 VRKFMAANWDKDEGEINLLEDCSTMII------NTACQCLFGEDLRKRLDARRFAQLLAK 189 Query: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV---KEHQESMDI 257 + ++ F I+ P + IL ++ ++ Sbjct: 190 MESSLI--------PAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKD 241 Query: 258 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 317 ++ D + L + ++ + ++ + + AG T+S T +++L L+ HP Sbjct: 242 SSTSDLLSGLLSAVYRDG----TPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLM-HP 296 Query: 318 ---EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDV 374 + +++EIE + + D MP+ + E R + L V DV Sbjct: 297 ANVKHLEALRKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPL-LMLMRKVMADV 353 Query: 375 KFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRI 434 K +Y++PKG I S HD + FP P +DP + K F+ F AG Sbjct: 354 KVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPER------DEKVEGAFIGFGAGVHK 407 Query: 435 CVGEGLARMELFLFLTFILQNFNLKSLIDP-KDLDTTPVVNGFAS 478 C+G+ +++ L ++++ + L D D D +V G + Sbjct: 408 CIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTA 452 >3JUS-A nrPDB Length = 461 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 78/449 (17%), Positives = 154/449 (34%), Gaps = 28/449 (6%) Query: 19 IWRQSSGRG-KLPPGPT-PLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVV 76 + +++ G K PP P+P +G+ + K + L N + YGPVF+ + Sbjct: 1 MAKKTLPAGVKSPPYIFSPIPFLGHAIAFG-KSPIEFLENAYEKYGPVFSFTMVGKTFTY 59 Query: 77 LHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG-KRWKEIRRF--SLMTLRN 133 L G + E+ + + G G+ + + E ++ S + + + Sbjct: 60 LLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAH 119 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQ 193 F IE +E E K IL + C + + Sbjct: 120 FKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCL------------HGKEI 167 Query: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE 253 L EK+ + + + P + + + + ++ + +++ ++ Sbjct: 168 RSQLNEKVAQLYADLDGGFSHAAWLLPGWLPL--PSFRRRDRAHREIKDIFYKAIQKRRQ 225 Query: 254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313 S + D + L K+ + T + + LL AG T+STT + L Sbjct: 226 SQE--KIDDILQTLLDATYKDGRP----LTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFL 279 Query: 314 LKHPEVTAKVQEEIERVVGRNRSPCMQD-RGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC 372 + + K E + V G N P D + D + E R I + Sbjct: 280 ARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMM-RMART 338 Query: 373 DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK 432 Y IP G + S T + F+P +L + + ++PF AG+ Sbjct: 339 PQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGR 398 Query: 433 RICVGEGLARMELFLFLTFILQNFNLKSL 461 C+GE A +++ + +L+ + + Sbjct: 399 HRCIGENFAYVQIKTIWSTMLRLYEFDLI 427 >2W0A-A nrPDB Length = 455 Score = 224 bits (572), Expect = 5e-59, Method: Composition-based stats. Identities = 73/431 (16%), Positives = 154/431 (35%), Gaps = 20/431 (4%) Query: 40 GNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGH 99 G++ + D + + G V T +++V+L G + ++ Sbjct: 17 GHLEEF-RTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKA 75 Query: 100 FPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT 159 +P + ++ +R KE+ + + +IED+V+ E Sbjct: 76 YPFMTPIFGEAVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAGE-- 133 Query: 160 KASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNF 219 D + + K+F Q KL + + P + Sbjct: 134 ----IDLLDFFAELTIYTSSACLIGKKFR---DQLDGRFAKLYHELERGTDPLAYVDPYL 186 Query: 220 PTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQ 279 P ++ L + +DI+ + + + RD +D LI ++ E Sbjct: 187 PI---ESFRRRDEARNGLVALVADIMNGRIANPPT--DKSDRDMLD-VLIAVKAETGTP- 239 Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 F+ + + ++ AG T+S T + L+ L++H + A V +E++ + G RS Sbjct: 240 -RFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSF 298 Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNK 399 +P + V+ E R + L + + + + I +G + S + Sbjct: 299 HALRQIPQLENVLKETLRLHPPL-IILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPE 357 Query: 400 EFPNPEMFDPRHFLDEG-GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 +FP+P F P + + ++PF AG+ CVG A M++ + +L+ + Sbjct: 358 DFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF 417 Query: 459 KSLIDPKDLDT 469 + P+ Sbjct: 418 EMAQPPESYRN 428 >5FSA-A nrPDB Length = 490 Score = 224 bits (570), Expect = 9e-59, Method: Composition-based stats. Identities = 93/494 (18%), Positives = 177/494 (35%), Gaps = 66/494 (13%) Query: 19 IWRQSSGRGKLPPGPTPL-PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 77 + +++ PP P G+ + + + + YG VF+ + M V Sbjct: 1 MAKKT------PPLVFYWIPWFGSAASYGQQ-PYEFFESCRQKYGDVFSFMLLGKIMTVY 53 Query: 78 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG-KRWKEIRRFSL--MTLRNF 134 G + + + S + G G+++ R E ++F+ +T +F Sbjct: 54 LGPKGHEFVFNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDSF 113 Query: 135 GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVI-----CSIIFQKRFDY 189 I + + + +E K K NV+ +I R + Sbjct: 114 KRYVPKIREEILNY--FVTDESFKLKEK--------THGVANVMKTQPEITIFTASRSLF 163 Query: 190 KDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAF-MESDILEKV 248 D+ + + + I FP + P H + + ++++ Sbjct: 164 GDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNL----PLPHYWRRDAAQKKISATYMKEI 219 Query: 249 KEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRY 308 K +E DI+ RD ID LI + + T + + +L G T+++T + Sbjct: 220 KLRRERGDIDPNRDLIDSLLIHSTYKDGVKM---TDQEIANLLIGILMGGQHTSASTSAW 276 Query: 309 ALLLLLKHPEVTAKVQEEIERVV----GRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364 LL L + P + + +E+ ++ G +D +P + + E R + Sbjct: 277 FLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL-H 335 Query: 365 SLPHAVTCDVKFR--NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK- 421 S+ VT ++ NY++PKG +L S + F NPE FDP + Sbjct: 336 SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSV 395 Query: 422 -------------------SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLI 462 S+ ++PF G+ C+GE A ++L LT + +NL+ I Sbjct: 396 SFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV--YNLRWTI 453 Query: 463 DP---KDLDTTPVV 473 D D D + +V Sbjct: 454 DGYKVPDPDYSSMV 467 >5L1U-A nrPDB Length = 401 Score = 221 bits (563), Expect = 5e-58, Method: Composition-based stats. Identities = 93/460 (20%), Positives = 156/460 (33%), Gaps = 96/460 (20%) Query: 46 DIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAER 105 DI ++ + L + GP+ + E ++ Y+ V+ L D S P A+ Sbjct: 16 DIMGIAPQMLAL-QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKS 74 Query: 106 ANRGFGIVFSNG-------KRWKEIR-----RFSLMTLRNFGMGKRSIEDRVQEEARCLV 153 A R F + + G R ++R RFS LR + K IE V E L Sbjct: 75 AARAFMVALAAGDDHETEPARHAQMRSLLIPRFSTRRLR---LMKTRIEHHVDELLDQL- 130 Query: 154 EELRKTKASPCDPTFILG-CAPCNVICSII---FQKRFDYKDQQFLNLMEKLNENIRIVS 209 A P D +L P V+C ++ R + + NE+ Sbjct: 131 ----AASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSA--- 183 Query: 210 TPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLI 269 N F ++DY +LE V + P D I LI Sbjct: 184 -------NTFQQVVDY------------------MLELVARKRV-----EPGDDILSELI 213 Query: 270 KMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 + + ++ +L G ETT + LLLL++P A++ E+ Sbjct: 214 A------EKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPG- 266 Query: 330 VVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTS---LPHAVTCDVKFRNYLIPKGTT 386 A V E+ R S +P D+ +I G Sbjct: 267 -----------------LAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDA 309 Query: 387 ILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELF 446 ++ ++ + +D++ FP+ +FD + + F G R C+G LAR+EL Sbjct: 310 VMLAIGAANYDDRAFPDGGLFDLTRV--------RPRSHLAFGHGARHCIGRTLARIELT 361 Query: 447 LFLTFILQNFNLKSLIDPKD---LDTTPVVNGFASVPPFY 483 + + L P++ + GF +P + Sbjct: 362 AVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF 401 >6C94-A nrPDB Length = 497 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 78/456 (17%), Positives = 166/456 (36%), Gaps = 32/456 (7%) Query: 31 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLE-RMVVLHGYEVVKEALID 89 PGP + G+ L+I + ++ + L+ G + ++ + K A+ Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIGFLNIYEPDYAK-AVYS 83 Query: 90 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149 G+ + G G++ +G +W + R+ + + + Sbjct: 84 RGDPKA--PDVYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVL--KPYVAIFADST 139 Query: 150 RCLVE--ELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRI 207 R ++E E + + D +G + + F K D + + Sbjct: 140 RIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGK----GDSGLNHRDSSYYVAVSE 195 Query: 208 VSTPWIQICNNFPTIIDY---FPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPR--- 261 ++ Q ++F D+ + L+ +++ + ++ R Sbjct: 196 LTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKEREKI 255 Query: 262 ------DFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315 DF+D L + + + +L + G +TT++ + + L + Sbjct: 256 QNRRHLDFLDILLD----VRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMAL 311 Query: 316 HPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 375 +PE + +EE+ ++G S +D M Y + E R +P + ++ V Sbjct: 312 YPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQ-VYRQLSKPVS 370 Query: 376 -FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRI 434 +P G+ I + ++ ++ +P+PE+FDP F E + + F+PFSAG R Sbjct: 371 FVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRN 430 Query: 435 CVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTT 470 C+G+ A E+ + L F +DP L Sbjct: 431 CIGQQFAMNEMKVVTALCLLRFEFS--VDPLRLPIK 464 >2Y5N-A nrPDB Length = 417 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 89/446 (19%), Positives = 156/446 (34%), Gaps = 88/446 (19%) Query: 55 TNLSKIYG------PVFTLYF-GLERMVVLHGYEVVKEALIDLGEEFSG---RGHFPLAE 104 L+ YG PV + E ++ YE V+ L D R Sbjct: 37 LTLAGRYGELQETEPVSRVRPPYGEEAWLVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRP 96 Query: 105 RANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPC 164 +G G++ + +RR + S+ R +E A LV+++ T P Sbjct: 97 EMVKG-GLLSMDPPEHSRLRRLVVKAFT--ARRAESLRPRAREIAHELVDQMAAT-GQPA 152 Query: 165 DPTFILGCA-PCNVICSIIF-----QKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNN 218 D + P VIC ++ RF FL+ E E ++ + Sbjct: 153 DLVAMFARQLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTAEEMQEAAE-------- 204 Query: 219 FPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQ 278 D++++ ++ P D + L++ ++Q Sbjct: 205 -----------------QAYAYMGDLIDRRRK--------EPTDDLVSALVQA----RDQ 235 Query: 279 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 338 Q + + L+ A LL AG E+T+T + + LL+ PE+ ++ + E + Sbjct: 236 QDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQLLDRPELI-------- 287 Query: 339 MQDRGHMPYTDAVVHEVQRYIDL-IPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD 397 + V E+ R++ L + T+ P DV R I G +L S + D Sbjct: 288 ----------PSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRD 337 Query: 398 NKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 457 +FP+ + D N + F G C+G LAR+EL + L +LQ Sbjct: 338 QAQFPDADRIDVDR---------TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRLP 388 Query: 458 LKSLIDPK---DLDTTPVVNGFASVP 480 L P+ ++ G +P Sbjct: 389 GIRLGIPETQLRWSEGMLLRGPLELP 414 >2VZM-A nrPDB Length = 436 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 95/470 (20%), Positives = 159/470 (33%), Gaps = 76/470 (16%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFG-LERMVVL 77 + R G PP +G + Q D + L + GP + + ++ Sbjct: 21 MRRTQQGTTASPPVLD----LGALGQDFAADPYPTYARL-RAEGPAHRVRTPEGNEVWLV 75 Query: 78 HGYEVVKEALIDLGEEFSGRGHF-PLAE-RANRGFGIVFSNGKRWKEIRRFSLMTLRNFG 135 GY+ + L D R PL E A ++ S+ R +R+ R F Sbjct: 76 VGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVA---REFT 132 Query: 136 MGKRSI-EDRVQEEARCLVEELRKTKASPCDPTFILG-CAPCNVICSIIFQKRFDYKDQQ 193 M + + RVQE LV+ + D L P VI + Sbjct: 133 MRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVIS-------------E 179 Query: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE 253 L + E R+ + ++ FP + +A M + Sbjct: 180 LLGVPEPDRAAFRVWTDAFV------------FPDDPAQAQTAMAEMSGYL--------S 219 Query: 254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313 + + + L + + S T E L+ A LL AG ETT + + L Sbjct: 220 RLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYAL 279 Query: 314 LKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCD 373 L HP+ A ++ + M D V E+ RY + ++ Sbjct: 280 LSHPDQLAALRAD------------------MTLLDGAVEEMLRYEGPVESATYRFPVEP 321 Query: 374 VKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKR 433 V +IP G T+L L + FP+P FD R + + F G Sbjct: 322 VDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRR---------DTAGHLAFGHGIH 372 Query: 434 ICVGEGLARMELFLFLTFILQNFNLKSL-IDPKDL--DTTPVVNGFASVP 480 C+G LAR+E + + +L+ +L + P +L P++ G ++P Sbjct: 373 FCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALP 422 >4WMZ-A nrPDB Length = 539 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 91/488 (18%), Positives = 165/488 (33%), Gaps = 50/488 (10%) Query: 24 SGRGKLPPGPTPL-PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEV 82 S R PP P +G+ + +K + K YG +F+ M V G + Sbjct: 50 SLRKDRPPLVFYWIPWVGSAVVYGMK-PYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKG 108 Query: 83 VKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG-KRWKEIRRFSLMTLRNFGMGKRSI 141 + + S + G G+++ R E ++F L +S Sbjct: 109 HEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTK--EAFKSY 166 Query: 142 EDRVQEEARCLVE-----ELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYK-DQQFL 195 + EE L + D + K K D F Sbjct: 167 VPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDF- 225 Query: 196 NLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESM 255 L ++ TP + N P + K + + +KE +++ Sbjct: 226 ---AYLYSDLDKGFTPINFVFPNLPL------EHYRKRDHAQKAISGTYMSLIKERRKNN 276 Query: 256 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315 DI + RD ID + + + T + + +L G T++ T + LL L + Sbjct: 277 DIQD-RDLIDSLMKNSTYKDGVKM---TDQEIANLLIGVLMGGQHTSAATSAWILLHLAE 332 Query: 316 HPEVTAKVQEEIERVV-GRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDV 374 P+V ++ EE RV+ G + MP + + E R + SL V D+ Sbjct: 333 RPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPL-HSLFRKVMKDM 391 Query: 375 KFRN--YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK----------- 421 N Y+IP G +L S ++ FPN F+ + ++ + Sbjct: 392 HVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGA 451 Query: 422 -----SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL-----KSLIDPKDLDTTP 471 S+ ++PF G+ C+GE A +L + ++ ++ K++ P Sbjct: 452 ISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVT 511 Query: 472 VVNGFASV 479 + G A + Sbjct: 512 LPTGPAKI 519 >5JLC-A nrPDB Length = 515 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 86/483 (17%), Positives = 169/483 (34%), Gaps = 62/483 (12%) Query: 24 SGRGKLPPGPTPL-PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEV 82 S R PP P +G+ + K + + K YG +F+ M V G + Sbjct: 32 SLRKDRPPLVFYWIPWVGSAIPYGTK-PYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKG 90 Query: 83 VKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGK-RWKEIRRFSLMTLRN-------- 133 + + S + G G+++ R E ++F L Sbjct: 91 HEFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVP 150 Query: 134 ------FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRF 187 + + S ++ E +V+ + I + S++ ++ Sbjct: 151 LIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPE-----MTIFTASR-----SLLGKEMR 200 Query: 188 DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK 247 D D F L ++ TP + N P + K + + Sbjct: 201 DKLDTDF----AYLYSDLDKGFTPINFVFPNLPL------EHYRKRDHAQQAISGTYMSL 250 Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 +KE +E DI N RD ID + + + T + + +L G T++ T Sbjct: 251 IKERREKNDIQN-RDLIDELMKNSTYKDGTKM---TDQEIANLLIGVLMGGQHTSAATSA 306 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRN-RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSL 366 + LL L + P+V ++ +E RV+ + + D +MP + ++ E R + SL Sbjct: 307 WCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPL-HSL 365 Query: 367 PHAVTCDVKFRN--YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--- 421 V DV N Y++P+ +L S + FP P F+ + + + Sbjct: 366 FRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGG 425 Query: 422 --------------SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL 467 S+ ++PF G+ C+GE A +L + ++ ++ + + + + Sbjct: 426 DEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETV 485 Query: 468 DTT 470 + Sbjct: 486 PPS 488 >3EJB-B nrPDB Length = 404 Score = 218 bits (554), Expect = 7e-57, Method: Composition-based stats. Identities = 86/446 (19%), Positives = 153/446 (34%), Gaps = 71/446 (15%) Query: 47 IKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERA 106 +K+ L ++ P++ F + GYE + A I F R P + Sbjct: 12 LKNPYSFYDTLRAVH-PIYKGSFLKYPGWYVTGYE--ETAAILKDARFKVRTPLPESSTK 68 Query: 107 NRG------FGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + ++F N + +R + S + + E L+++++ K Sbjct: 69 YQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRT--TESYQPYIIETVHHLLDQVQGKK 126 Query: 161 ASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFP 220 F A VI +II + E+ E ++ + IQ + Sbjct: 127 KMEVISDFAFPLASF-VIANII-------------GVPEEDREQLKEWAASLIQTIDFTR 172 Query: 221 TIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS 280 + G N + ++++K K H + +D I L EK+K Sbjct: 173 SRKALTEG--NIMAVQAMAYFKELIQKRKRHPQ-------QDMISMLLKGREKDK----- 218 Query: 281 EFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQ 340 T E T L AG ETT + ++L LL+HPE K++E + + Sbjct: 219 -LTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLI---------- 267 Query: 341 DRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE 400 V E RY + + D+ I +G + L + D Sbjct: 268 --------GTAVEECLRYESPTQMTA-RVASEDIDICGVTIRQGEQVYLLLGAANRDPSI 318 Query: 401 FPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKS 460 F NP++FD N + F G +C+G LAR+E + + +LQ + Sbjct: 319 FTNPDVFDITR---------SPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLN 369 Query: 461 LIDPKDLDTTPV--VNGFASVPPFYQ 484 L D + P+ +P ++ Sbjct: 370 LAD-FEWRYRPLFGFRALEELPVTFE 394 >5VWS-A nrPDB Length = 393 Score = 217 bits (553), Expect = 9e-57, Method: Composition-based stats. Identities = 82/425 (19%), Positives = 149/425 (35%), Gaps = 74/425 (17%) Query: 63 PVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKE 122 PV+ FG + + Y+ V++ L D S R + GI + + Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRH 88 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSI 181 RR + +E R+++ A L++EL D P VI + Sbjct: 89 QRRLITHAFTPQSISA--MEPRIRQIADHLLDEL---PGPEFDLVEHFAYPLPVIVIAEL 143 Query: 182 IF---QKR--FDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKN 236 + R F + ++L + + + + Sbjct: 144 LGVPPGDRHLFRTWSDRLMSLQVENYADPELA--------------------------RT 177 Query: 237 LAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLG 296 +A +++ + ++EH S +PRD + L++ E E + +E +V TA+ LL Sbjct: 178 VAAAMTEMNDYLREHCRSRR-THPRDDLLTRLVQAEVEGK----RLDLEEVVNTASLLLL 232 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQ 356 AG TT+ + +L L HPE V+ + + A + E Sbjct: 233 AGHLTTTVLIGNTMLCLWDHPEAEKAVRADPSLI------------------PAALEESL 274 Query: 357 RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416 R + T DV IP ++ + S HD++ FP+PE FD Sbjct: 275 RLRSPFLQA-GRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFD-------- 325 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDT-TPVVNG 475 +++ + F G C+G L R+E + L +L F + + + G Sbjct: 326 -LHRQTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFTEIHPWPREGISFYQSAIFG 384 Query: 476 FASVP 480 + +P Sbjct: 385 ASRMP 389 >3EL3-A nrPDB Length = 467 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 83/434 (19%), Positives = 161/434 (37%), Gaps = 24/434 (5%) Query: 35 PLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEF 94 +P++G+ ++ +D ++ L +G V + G + + + E+ ++ Sbjct: 30 GVPLLGHGWRL-ARDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI 87 Query: 95 SGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVE 154 +G + E G+ +NG + RR R + ++EEA L E Sbjct: 88 AG-PLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRL--DAIPAYGPIMEEEAHALTE 144 Query: 155 ELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFL--NLMEKLNENIRIVSTPW 212 R D T V + + ++ + + L L R + P Sbjct: 145 --RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPL 202 Query: 213 IQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKME 272 + F N L +L + +I+ + + + D + L++ + Sbjct: 203 GPLYRLPLPANRRF----NDALADLHLLVDEIIAERRASGQKP------DDLLTALLEAK 252 Query: 273 KEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVG 332 + + E I + +L G+ET ++T+ + L L HPE ++++E+E V G Sbjct: 253 DDNGDPIGEQEIHD---QVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG 309 Query: 333 RNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLT 392 R +D + +T V+ E R + L + + Y IP G I+ S Sbjct: 310 -GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGADIIYSPY 367 Query: 393 SVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFI 452 ++ D K + + FDP +L E PFSAGKR C + + +L L + Sbjct: 368 AIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAAL 427 Query: 453 LQNFNLKSLIDPKD 466 + + + D Sbjct: 428 ATKYRFEQVAGSND 441 >6CR2-A nrPDB Length = 477 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 83/476 (17%), Positives = 168/476 (35%), Gaps = 48/476 (10%) Query: 19 IWRQSSGRGKLPPGPTPL-PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 77 + +++ PP P IG+ + I D K + YG +FT ++ V Sbjct: 1 MAKKT------PPVVFHWFPFIGSTISYGI-DPYKFFFDCRAKYGDIFTFILLGKKTTVY 53 Query: 78 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG-KRWKEIRRFSLMTLRNFGM 136 G + L + + G +V+ + E ++F L + + Sbjct: 54 LGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDAL 113 Query: 137 GKRSIEDRVQEEARCLVEELRKTKA--SPCDPTFILGCAPCNVICSIIFQKRFDYKDQQF 194 RS + +E V+ + D + + K K F Sbjct: 114 --RSYVPLITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSK---F 168 Query: 195 LNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESD-ILEKVKEHQE 253 + +L N+ + P ++ + P HN+ ++ +E +K ++ Sbjct: 169 DSTFAELYHNLDMGFAP-------INFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQ 221 Query: 254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313 + + D + + + K + E + LL AG ++S+T + +L L Sbjct: 222 AGSKKDSEDMVWNLMSCVYKNG----TPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRL 277 Query: 314 LKHPEVTAKVQEEIERVVGRNRSPCMQD-RGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC 372 P++ ++ +E RV+G + P D + V+ E R I S+ AV Sbjct: 278 ATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPI-HSIIRAVKN 336 Query: 373 DVKFRN--YLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN------- 423 + Y+IP +L+S + FPNP ++P + + + + Sbjct: 337 PMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGY 396 Query: 424 ---------YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTT 470 ++PF AG+ C+GE A ++L +++ F ++L + T Sbjct: 397 GLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDT 452 >5CJE-A nrPDB Length = 393 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 81/454 (17%), Positives = 146/454 (32%), Gaps = 76/454 (16%) Query: 39 IGNILQID------IKDVSKSLTNLSKIYGPVFTLYFGLERM---VVLHGYEVVKEALID 89 +GN++ + +D L + GPV + ++ G+E + AL D Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALAD 59 Query: 90 LGEEFSG-RGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEE 148 G + + G ++ + +R + ++ R+QE Sbjct: 60 PRLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTMRRV--EALRPRIQEI 117 Query: 149 ARCLVEE-LRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRI 207 L++E L + +A D P VIC ++ D + NE + Sbjct: 118 TDGLLDEMLPRGRADLVD--SFAYPLPITVICELL-----GVPDIDRVTFRALSNEIVAP 170 Query: 208 VSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCF 267 + LA ++++ + P D + Sbjct: 171 TGG-----------------DAELAAYERLAAYLDELIDDKRS-------TAPADDLLGD 206 Query: 268 LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEI 327 LI+ E + E L A LL AG ETT + + LL HP+ A ++ + Sbjct: 207 LIRTRAED---DDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD- 262 Query: 328 ERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTI 387 M D V EV R+ + T+ ++ I +G + Sbjct: 263 -----------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPV 305 Query: 388 LTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFL 447 + L + D P+P +FD + F G C+G LAR+E + Sbjct: 306 MIGLDAAGRDPARHPDPHVFDIHR---------APQGHLAFGHGIHYCLGAPLARLEARV 356 Query: 448 FLTFILQNFNLKSL-IDPKDLDTTPVVNGFASVP 480 L +L+ +L P ++ G +P Sbjct: 357 ALRSLLERCPDLALDGPPGARPPGMLIRGVRRLP 390 >3A50-A nrPDB Length = 411 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 86/445 (19%), Positives = 147/445 (33%), Gaps = 75/445 (16%) Query: 48 KDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERAN 107 ++ + L + PV L + +L Y V+EA +D R P +RA+ Sbjct: 20 QNPHPAYAAL-RAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRAD 78 Query: 108 RGF----GIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASP 163 ++ + +R+ + M +E R+ E A L+ L P Sbjct: 79 MPATPTPMMILMDPPDHTRLRKLVGRSFTVRRM--NELEPRITEIADGLLAGLPTD--GP 134 Query: 164 CDPTFILGCA-PCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTI 222 D P VIC ++ D D + W + Sbjct: 135 VDLMREYAFQIPVQVICELLGLPAEDRDD-----------------FSAWS------SVL 171 Query: 223 IDYFPGT-HNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSE 281 +D P N + L SD+LE+ + P D + L+ + ++ Sbjct: 172 VDDSPADDKNAAMGKLHGYLSDLLERKR--------TEPDDALLSSLLAVSDMDGDR--- 220 Query: 282 FTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQD 341 + E LV A LL AG ETT + +L LL HP+ + E+ + Sbjct: 221 LSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLI----------- 269 Query: 342 RGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF 401 + V E R+ + + DV + IP G ++ L + D Sbjct: 270 -------SSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWM 322 Query: 402 PNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFIL-QNFNLKS 460 P P+ D G + F G C+G LAR+E + + + L Sbjct: 323 PEPDRLDITRDASGG---------VFFGHGIHFCLGAQLARLEGRVAIGRLFADRPELAL 373 Query: 461 LIDPKDL--DTTPVVNGFASVPPFY 483 + +L + +V G + +P Sbjct: 374 AVGLDELVYRRSTLVRGLSRMPVTM 398 >2VE3-A nrPDB Length = 444 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 87/439 (19%), Positives = 163/439 (37%), Gaps = 36/439 (8%) Query: 29 LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALI 88 +PPG LP +G L + +GP+F + ++ + G + Sbjct: 13 IPPGDFGLPWLGETLNFLNDG--DFGKKRQQQFGPIFKTRLFGKNVIFISGALANRFLFT 70 Query: 89 DLGEEFSGRGHFPLAERANRG-FGIVFSNGKRWKEIRRFSLMTL--RNFGMGKRSIEDRV 145 E F + +PL+ R G + G+ + R+ R ++ V Sbjct: 71 KEQETF--QATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIV 128 Query: 146 QEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENI 205 Q + KA+ L +V ++ ++ Q F Sbjct: 129 QGYLE------QWGKANEVIWYPQLRRMTFDVAATLFMGEKVSQNPQLF----------- 171 Query: 206 RIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID 265 PW + + N L + +L ++++ ++ P + + Sbjct: 172 -----PWFETY--IQGLFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQPPSE--E 222 Query: 266 CFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQE 325 L + + + ++ L LL AG ET ++ L LLL +H ++ +V++ Sbjct: 223 DALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQ 282 Query: 326 EIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGT 385 E + + ++ + MPY D V+ EV R I + + D +F+ + PKG Sbjct: 283 E-QNKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGF-RELIQDCQFQGFHFPKGW 340 Query: 386 TILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN-FKKSNYFMPFSAGKRICVGEGLARME 444 + ++ D +P+PE FDP F +G +PF G R C+G+ AR+E Sbjct: 341 LVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLE 400 Query: 445 LFLFLTFILQNFNLKSLID 463 + LF T ++Q F+ L Sbjct: 401 MKLFATRLIQQFDWTLLPG 419 >3N9Z-A nrPDB Length = 487 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 80/439 (18%), Positives = 162/439 (36%), Gaps = 16/439 (3%) Query: 31 PGPTPLPVIGNIL-QIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89 PG + + + V + YGP++ G V + E V Sbjct: 14 PGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKS 73 Query: 90 LG---EEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQ 146 G E F + R G++ WK+ R +L ++ + Sbjct: 74 EGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDR-VALNQEVMAPEATKNFLPLLD 132 Query: 147 EEARCLVEELRK------TKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 200 +R V L + + D + L I ++IF +R ++ ++ Sbjct: 133 AVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQR 192 Query: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNP 260 + I + + + N P + F K K+ I K + ++ Sbjct: 193 FIDAIYQMFHTSVPMLNLPPDLFRLF---RTKTWKDHVAAWDVIFSKADIYTQNFYWELR 249 Query: 261 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 320 + + + S+ + E++ ++L G +TTS TL++ L + ++ +V Sbjct: 250 QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQ 309 Query: 321 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYL 380 ++ E+ + + +P A + E R I +L + D+ R+Y+ Sbjct: 310 DMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRL-HPISVTLQRYLVNDLVLRDYM 368 Query: 381 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGL 440 IP T + ++ ++ + F +PE FDP +L + N + F G R C+G + Sbjct: 369 IPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNI-TYFRNLGFGWGVRQCLGRRI 427 Query: 441 ARMELFLFLTFILQNFNLK 459 A +E+ +FL +L+NF ++ Sbjct: 428 AELEMTIFLINMLENFRVE 446 >1Z8P-A nrPDB Length = 404 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 82/435 (18%), Positives = 151/435 (34%), Gaps = 80/435 (18%) Query: 63 PVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGF------------ 110 PV + F + ++ GY+ K AL DL + +P E + Sbjct: 28 PVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFA 87 Query: 111 -GIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 + S+ +R+ + ++ RV++ L++E+ + D Sbjct: 88 TNMGTSDPPTHTRLRKLVSQEFTVRRV--EAMRPRVEQITAELLDEVGDS--GVVDIVDR 143 Query: 170 LGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG 228 P VIC + L + EK S+ I+ P Sbjct: 144 FAHPLPIKVIC-------------ELLGVDEKYRGEFGRWSS----------EILVMDPE 180 Query: 229 THNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLV 288 + + + + IL+ V+ + P D + LI+++ + + + L Sbjct: 181 RAEQRGQAAREVVNFILDLVERRR-----TEPGDDLLSALIRVQDDD---DGRLSADELT 232 Query: 289 ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT 348 A LL AG E++ + + LLL HP+ A V+ + Sbjct: 233 SIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSA------------------L 274 Query: 349 DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD 408 V E+ RYI P + +V+ IP+ +T+L + + D K+FP+P FD Sbjct: 275 PNAVEEILRYIAP-PETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFD 333 Query: 409 PRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSL---IDPK 465 + + + F G C+G LA++E + L + F SL D Sbjct: 334 ---------VTRDTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDV 384 Query: 466 DLDTTPVVNGFASVP 480 + ++ G +P Sbjct: 385 VWRRSLLLRGIDHLP 399 >6A7J-A nrPDB Length = 411 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 81/429 (18%), Positives = 147/429 (34%), Gaps = 78/429 (18%) Query: 62 GPVFTLYF-GLERMVVLHGYEVVKEALIDLGEEFS-------GRGHFP----LAERANRG 109 GP+ + G + + ++ + L D RG P L N G Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPG 85 Query: 110 FGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT-KASPCDPTF 168 ++ +G + +R L + K + ++ +E L P D Sbjct: 86 RSMLTVDGPDHRRLRTLVAQALTVKRVEK--LRAGIEALTNASLERLAALPAGEPVDLKA 143 Query: 169 ILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP 227 P NVI ++ D+ L E + P Sbjct: 144 EFAYPLPMNVISELMGVDAADHP-----RLKELFEKFFST----------------QTPP 182 Query: 228 GTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENL 287 +++ +L + + I+E+ K NP D + LI ++ T E + Sbjct: 183 EEVPQMMADLGTLFTKIVEEKKA--------NPGDDLTSALIAASEDG----DHLTDEEI 230 Query: 288 VITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPY 347 + T ++ AG ETT + + + L HPE KV G +P+ Sbjct: 231 LNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKVLS-----------------GEIPW 273 Query: 348 TDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEM 406 + V+ E R+ L T D++ + ++PKG ++ S ++ D +++ P Sbjct: 274 -EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGD 332 Query: 407 FDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP-K 465 FD + N + F G +C G L+R+E + L + + F L P Sbjct: 333 FD---------ATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAA 383 Query: 466 DLDTTPVVN 474 +L P+V Sbjct: 384 ELRNKPIVT 392 >5L94-A nrPDB Length = 410 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 76/414 (18%), Positives = 142/414 (34%), Gaps = 65/414 (15%) Query: 72 ERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTL 131 ++ + Y+ VKE L S R + G ++ + + E+R Sbjct: 44 RQVWDVFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLINIDPPKHAEMRALVNKAF 103 Query: 132 RNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIF---QKRF 187 M ++ E ++ L++E D L P VI I+ + + Sbjct: 104 TPKAM--KAWEPKIARITNELLQE--VEHLEDIDIVEHLSYPLPVMVIADILGVPIEDQR 159 Query: 188 DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK 247 +KD + IV+ P + + +K +E+ Sbjct: 160 QFKDWSDI-----------IVAGPSNNERETLEKL-------QQEKMKANDELETYFYRI 201 Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 ++E + P D I L++ ++E + + T E +V + LL AG ETT+ + Sbjct: 202 IEEKR-----TRPGDDIISVLLQAKEEGK----QLTDEEIVGFSILLLIAGNETTTNLIS 252 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP 367 + L++ +++ E E + + EV RY + +L Sbjct: 253 NTIYCLMEDKASFERLKREKE------------------LLPSGIEEVLRYRSPVQ-ALH 293 Query: 368 HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMP 427 V DV + G ++ + S D + F +PE+F K N M Sbjct: 294 RIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR---------KPNVHMA 344 Query: 428 FSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDT--TPVVNGFASV 479 F G C+G LAR+E + L ++ + +L + V G + Sbjct: 345 FGRGIHFCLGAPLARIEAKIMLAELIDRYPQMDWSPSFELKPIESTFVYGLKEL 398 >4OQS-A nrPDB Length = 433 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 86/420 (20%), Positives = 142/420 (33%), Gaps = 85/420 (20%) Query: 75 VVLHGYEVVKEALIDLGEEFSGRGHF--PLAERANRGFGIVFSNGKRW------KEIRRF 126 ++ + + +ID FS R P+ R G + W E R+ Sbjct: 48 WLVTSHAAARTVMID--PRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFINMDAPEHTRY 105 Query: 127 SLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFQ 184 M + F + + + +E R+ + ++ + K P D P VIC ++ Sbjct: 106 RRMLISQFTVRRIKELEPRIVQITEDHLDAMAKA-GPPVDLVQAFALPVPSLVICELLG- 163 Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244 Y D F + ++ T +++ L + I Sbjct: 164 --VSYADHAFFQEQTTIMASVD---------------------KTQDEVTTALGKLTRYI 200 Query: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304 E V + S P+D + LI ++ T E L A LL AG ETT+ Sbjct: 201 AELVATKRLS-----PKDDLLGSLIT--------DTDLTDEELTNIALLLLVAGHETTAN 247 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364 L LL+HPE A + + V E+ RY+ ++ Sbjct: 248 MLGLGTFALLQHPEQIAALD-----------------------SPDAVEELLRYLSIVHL 284 Query: 365 SLP-HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423 P A DV+ +I KG T+ L +V D K F P++ + Sbjct: 285 GTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRV--------DAR 336 Query: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD---LDTTPVVNGFASVP 480 F G C+G+ LAR+E+ + T + F L P + L G ++P Sbjct: 337 KHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYGVWALP 396 >2ZBZ-A nrPDB Length = 412 Score = 202 bits (514), Expect = 3e-52, Method: Composition-based stats. Identities = 81/445 (18%), Positives = 147/445 (33%), Gaps = 79/445 (17%) Query: 49 DVSKSLTNLSKIYGPVFTLYF-GLERMVVLHGYEVVKEALIDLGEEFSGRGH--FPLAER 105 + L GP+ + + V+ +E ++ L D S R FP Sbjct: 25 QLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLS-SNRTDDNFPATSP 83 Query: 106 ANRG-----FGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKT 159 A + + RR MT+ F + + + + V+E ++E+ Sbjct: 84 AFEAVRESPQAFIGLDPPEHGTRRR---MTISEFTVKRIKGMRPEVEEVVHGFLDEMLAA 140 Query: 160 KASPCDPTFILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNN 218 D P VIC ++ Y D +F + S +Q + Sbjct: 141 -GPTADLVSQFALPVPSMVICRLLG---VPYADHEF----------FQDASKRLVQSTDA 186 Query: 219 FPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQ 278 + +LA ++ + + + L+ Q Sbjct: 187 QSAL---------TARNDLAGYLDGLITQFQTEPGAG------------LVGALVADQLA 225 Query: 279 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 338 E E L+ TA LL AG ETT++ +++ LL HPE A ++ + V G Sbjct: 226 NGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPG------ 279 Query: 339 MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 V E+ RY+ + + T D++ LI G ++ + D Sbjct: 280 ------------AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDG 327 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 + +P+ D + + + F G C+G+ LAR+EL + L ++ Sbjct: 328 TVYEDPDALDIHR---------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPT 378 Query: 459 KSLIDPKD---LDTTPVVNGFASVP 480 L P + L + G +P Sbjct: 379 LRLAVPVEQLVLRPGTTIQGVNELP 403 >4OQR-A nrPDB Length = 457 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 86/420 (20%), Positives = 141/420 (33%), Gaps = 85/420 (20%) Query: 75 VVLHGYEVVKEALIDLGEEFSGRGHF--PLAERANRGFGIVFSNGKRW------KEIRRF 126 ++ + + +ID FS R P+ R G + W E R+ Sbjct: 87 WLVTSHAAARTVMID--PRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFTNMDAPEHTRY 144 Query: 127 SLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFQ 184 M + F + + + +E R+ ++ + K P D P VIC ++ Sbjct: 145 RRMLISQFTVRRIKELEPRIVRITEDHLDAMAKA-GPPVDLVQAFALPVPSLVICELLG- 202 Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244 Y D F + ++ T +++ L + I Sbjct: 203 --VSYADHAFFQEQTTIMVSVD---------------------KTQDEVTTALGKLTRYI 239 Query: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304 E V + S P+D + LI ++ T E L A LL AG ETT+ Sbjct: 240 AELVATKRLS-----PKDDLLGSLIT--------DTDLTDEELTNIALILLVAGHETTAN 286 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364 L LL+HPE A + + V E+ RY+ ++ Sbjct: 287 MLGLGTFALLQHPEQIANLD-----------------------SPDAVEELLRYLSIVHL 323 Query: 365 SLP-HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423 P A DV+ +I KG T+ L +V D K F P++ + Sbjct: 324 GTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRV--------DAR 375 Query: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD---LDTTPVVNGFASVP 480 F G C+G+ LAR+E+ + T + F L P + L G ++P Sbjct: 376 KHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYGVWALP 435 >3MZS-A nrPDB Length = 486 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 88/447 (19%), Positives = 166/447 (37%), Gaps = 31/447 (6%) Query: 31 PGPTPLPVIGNIL-QIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89 PG + + + + + + YGP++ G V + E V Sbjct: 16 PGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKF 75 Query: 90 LG---EEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQ 146 G E + + G++F WK+ R L T ++ + Sbjct: 76 EGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDR-VVLNTEVMAPEAIKNFIPLLN 134 Query: 147 EEARCLVEELRK---TKASP---CDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 200 ++ V L K + S D L I +++F +R ++ +K Sbjct: 135 PVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQK 194 Query: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESM--DIN 258 + + + + + N P + F K ++ I K +++ E D+ Sbjct: 195 FIDAVYKMFHTSVPLLNVPPELYRLF---RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLR 251 Query: 259 NPRDF-----IDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313 +F I L+K EK +E++ ++L G TTS TL++ L + Sbjct: 252 RKTEFRNYPGILYCLLKSEK--------MLLEDVKANITEMLAGGVNTTSMTLQWHLYEM 303 Query: 314 LKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCD 373 + V ++EE+ + + +P A + E R I +L D Sbjct: 304 ARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRL-HPISVTLQRYPESD 362 Query: 374 VKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKR 433 + ++YLIP T + ++ ++ D F +P+ FDP +L + + + F G R Sbjct: 363 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIH-FRNLGFGWGVR 421 Query: 434 ICVGEGLARMELFLFLTFILQNFNLKS 460 CVG +A +E+ LFL IL+NF ++ Sbjct: 422 QCVGRRIAELEMTLFLIHILENFKVEM 448 >4UBS-A nrPDB Length = 393 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 75/422 (17%), Positives = 141/422 (33%), Gaps = 79/422 (18%) Query: 71 LERMVVLHGYEVVKEALIDLGEEFSGR--GHFPLAERAN-----RGFGIVFSNGKRWKEI 123 + V+ G+ + L D S R FP R ++ + + Sbjct: 36 GRSVWVVTGHAAARALLSDQRLS-SDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQ 94 Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSII 182 RR + + + R+QE L++ + + P + P VIC+++ Sbjct: 95 RRMLVPSFTLKRAAA--LRPRIQETVDGLLDAMEA-QGPPAELVSAFALPLPSMVICALL 151 Query: 183 FQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME- 241 D+ D+F +LL+ E Sbjct: 152 GVPYADH----------------------------------DFFESQSRRLLRGPGIAEV 177 Query: 242 SDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTET 301 D ++ ++ ++ ++ D L + +E Q + LV A LL AG ET Sbjct: 178 QDARAQLDDYLYALIDRKRKEPGDGLLDDLIQE-QLNRGTVDRAELVSLATLLLIAGHET 236 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL 361 T+ + LL+HPE A+++ E A V E+ R++ + Sbjct: 237 TANMISLGTFTLLRHPEQLAELRAEPG------------------LMPAAVEELLRFLSI 278 Query: 362 IPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK 421 L T D++ I ++ + + + D F P+ D + Sbjct: 279 AD-GLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALD---------WHRS 328 Query: 422 SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD-LDTTP--VVNGFAS 478 + + + F G C+G+ LAR E+ + L + + L P D + P + G Sbjct: 329 ARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFKPGDTIQGMLE 388 Query: 479 VP 480 +P Sbjct: 389 LP 390 >4Z5P-A nrPDB Length = 400 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 78/460 (16%), Positives = 152/460 (33%), Gaps = 88/460 (19%) Query: 36 LPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYF-GLERMVVLHGYEVVKEALIDLGEEF 94 P G ++D ++ L + P+ + ++ Y+ V+ A + F Sbjct: 11 YPFEG---EVDGLEIHPKFAELRET-DPLARVRLPYGGEGWMVTRYDDVRAA--NSDPRF 64 Query: 95 S----GRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEAR 150 S G A R I+ + +RR MG ++ ++E Sbjct: 65 SRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMGA--MQSWLEELFA 122 Query: 151 CLVEELRKTKASPCDP-TFILGCAPCNVICSIIF-----QKRFDYKDQQFLNLMEKLNEN 204 L++ + +T P D + VIC ++ + RF + + ++ E Sbjct: 123 GLLDGVERT-GHPADIVRDLAQPFTIAVICRLLGVPYEDRGRFQHWSEVIMSTTAYSKE- 180 Query: 205 IRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFI 264 + + A + + + + V + + P D + Sbjct: 181 ---------------------------EAVSADASIRAYLADLVSARRAA-----PHDDL 208 Query: 265 DCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 L+ ++ T + L+ LL AG ET++ L + LL H + + ++ Sbjct: 209 LGVLVSA----RDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLR 264 Query: 325 EEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLI-PTSLPHAVTCDVKFRNYLIPK 383 E+ E V E+ R++ L DV+ + Sbjct: 265 EQPE------------------LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRA 306 Query: 384 GTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARM 443 G ++ + + D + F +P+ D + N + F G C+G LARM Sbjct: 307 GEGVVAAAVNANRDPRAFDDPDRLDITR---------EKNPHLAFGHGAHYCLGAQLARM 357 Query: 444 ELFLFLTFILQNFNLKSLIDPKD---LDTTPVVNGFASVP 480 EL + + +L+ F L P D T + G +P Sbjct: 358 ELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQRLP 397 >4WPZ-A nrPDB Length = 397 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 80/425 (18%), Positives = 146/425 (34%), Gaps = 89/425 (20%) Query: 75 VVLHGYEVVKEALIDLGEEFSGRGHFPLAERAN-------RGFGIVFSNGKRWKEIRRFS 127 ++ + V++ L+D FS + A + +V + +R+ Sbjct: 40 WMVTKHADVRKVLVD--SRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRKLV 97 Query: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIF--- 183 ++ R+ E L++EL P D P VIC ++ Sbjct: 98 TKAFT--ARRVETLRPRITELVGQLLDELETLP-RPVDLVKNFSVPLPVRVICELLGVPA 154 Query: 184 --QKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME 241 Q F L W Q+ +L Sbjct: 155 GDQDTFHAWSNALLG--------------DWQQVVE------------KEAATVSLVNYF 188 Query: 242 SDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTET 301 +++ +E NP D + LI + + S T ++ + +L AG ET Sbjct: 189 GELIAVKRE--------NPADDLISELIAIS----DGDSTLTEREIIALSIGILSAGHET 236 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL 361 T+ + L+ LL +PE K+++ E + V E+ R++ L Sbjct: 237 TANQISMFLVTLLHNPEELDKLRDNREAI------------------PKAVDELLRFVPL 278 Query: 362 IPTS--LPHAVTCDVKF-RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN 418 T +P T +V+ ++P G +L ++ + D + F + E + Sbjct: 279 TTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLN---------V 329 Query: 419 FKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPK---DLDTTPVVNG 475 +++N + F AG C+G LAR+EL L IL L P+ L + ++ G Sbjct: 330 TRENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRG 389 Query: 476 FASVP 480 S+P Sbjct: 390 LESLP 394 >6A7I-A nrPDB Length = 411 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 81/429 (18%), Positives = 143/429 (33%), Gaps = 78/429 (18%) Query: 62 GPVFTLYF-GLERMVVLHGYEVVKEALIDLGEEFS-------GRGHFP----LAERANRG 109 GP+ + G + + + + L D RG P L AN G Sbjct: 26 GPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKDIDVWNAWRRGEIPMDWPLIGLANPG 85 Query: 110 FGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT-KASPCDPTF 168 ++ +G + +R L + + ++ +E+L P D Sbjct: 86 RSMLTVDGADHRRLRTLVAQALTVKRV--ERLRAGIEALTNASLEKLAALPAGEPVDLKA 143 Query: 169 ILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP 227 P NVI ++ D+ L E + P Sbjct: 144 EFAYPLPMNVISELMGVDAADHP-----RLKELFEKFFST----------------QTPP 182 Query: 228 GTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENL 287 +++ +L + + I++ + NP D + LI T E + Sbjct: 183 EEVPQMMADLGALFTKIVDAKR--------TNPGDDLTSALIAAS----ENGDHLTDEEI 230 Query: 288 VITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPY 347 V T ++ AG ETT + + + L HPE KV G + + Sbjct: 231 VNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKVL-----------------NGEIGW 273 Query: 348 TDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEM 406 D V+ E R+ L T D++ + ++PKG ++ S ++ D +++ P Sbjct: 274 -DGVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGE 332 Query: 407 FDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP-K 465 FD + N + F G +C G L+R+E + L + + F L P Sbjct: 333 FD---------ATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAS 383 Query: 466 DLDTTPVVN 474 DL P+V Sbjct: 384 DLRNKPIVT 392 >5EX6-C nrPDB Length = 434 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 79/421 (18%), Positives = 138/421 (32%), Gaps = 86/421 (20%) Query: 62 GPVFTLYFGL----ERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGI----- 112 G + + G E + G++VV++ L D FS R F + G G+ Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDH-TRFSTRRRFDRNDEI-GGKGVFRPRE 119 Query: 113 -----VFSNGKRWKEIRRF--SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCD 165 + + +RR T R IE V E + E SP D Sbjct: 120 LVGNLMDYDPPEHTRLRRLLAPGFTHRKIRRMAPYIEQIVTERLDEMERE-----GSPAD 174 Query: 166 PTFIL-GCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIID 224 + P V+C ++ R D ++ + ++ + Sbjct: 175 LIELFADEVPGPVLCELLGVPRDDR-----AMFLQLCHRHLDASLS-------------- 215 Query: 225 YFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTI 284 + E + +M +D D + + E + T Sbjct: 216 -------------GRRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHGD---TVTD 259 Query: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344 E L ++ AG + S + +L LL++PE A ++ G Sbjct: 260 EELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALR------------------GD 301 Query: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404 +P + V E+ RY+ + P D + +I G T+L SL + D P+ Sbjct: 302 VPAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDA 361 Query: 405 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP 464 + D +++ + F G C+G LAR+EL + T + + F L DP Sbjct: 362 DRLD---------VTREAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADP 412 Query: 465 K 465 Sbjct: 413 D 413 >2Z36-A nrPDB Length = 413 Score = 194 bits (494), Expect = 6e-50, Method: Composition-based stats. Identities = 82/445 (18%), Positives = 142/445 (31%), Gaps = 78/445 (17%) Query: 50 VSKSLTNLSKIYGPVFTLYF-GLERMVVLHGYEVVKEALIDLGEEFSGRGH-FPLA---- 103 + L + P+ + + + G+E + L D R FPL Sbjct: 24 PPAAYERLRER-APINKVRLTSGGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDA 82 Query: 104 ----ERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT 159 + ++ ++ +G RR + + + R+Q+ ++++ T Sbjct: 83 ATLQQLRSQPPLMLGMDGAEHSAARRPVIGEFTVKRLAA--LRPRIQDIVDHFIDDMLAT 140 Query: 160 KASPCDPTFILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNN 218 P D L P VIC ++ Y D F Sbjct: 141 DQRPVDLVQALSLPVPSLVICELLG---VPYTDHDFFQ-------------------SRT 178 Query: 219 FPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQ 278 + + L D++ + + + P D L + +Q Q Sbjct: 179 TMMVSRTSMEDRRRAFAELRAYIDDLITRKE--------SEPGDD----LFSRQIARQRQ 226 Query: 279 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 338 + LV A LL AG ETT+ + ++ LL HPE V+ R Sbjct: 227 EGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKANPGR--------- 277 Query: 339 MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 T V E+ RY + T DV+ I G ++ S+ S D Sbjct: 278 ---------TPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDP 328 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 F +P + D + + + F G C+G+ LARMEL + + + Sbjct: 329 AVFKDPAVLDVER---------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPS 379 Query: 459 KSLIDP-KDLDTT--PVVNGFASVP 480 L P +D+ V+ G +P Sbjct: 380 LRLAVPMEDVPFKGDSVIYGVHELP 404 >4KPA-A nrPDB Length = 494 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 87/442 (19%), Positives = 158/442 (35%), Gaps = 34/442 (7%) Query: 31 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDL 90 P P + N+ ++ ++L ++ G +F L ++KEA Sbjct: 30 PQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEAC--D 87 Query: 91 GEEFSGRGHFPLAERANRGFGIVFSNGKR---WKE-----IRRFSLMTLRNF-GMGKRSI 141 F L + +F++ WK+ + FS ++ + M Sbjct: 88 ESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIA 147 Query: 142 EDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRF-DYKDQQFLNLMEK 200 VQ+ R +E P D T + + I F RF + Q + Sbjct: 148 VQLVQKWERLNADE---HIEVPEDMTRL----TLDTIGLCGFNYRFNSFYRDQPHPFITS 200 Query: 201 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNP 260 + + + + P Y + + +D+++K+ +++ + Sbjct: 201 MVRALDEAMNKLQRANPDDPA---YDENKRQ--FQEDIKVMNDLVDKIIADRKASGEQS- 254 Query: 261 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 320 D + L + E EN+ L AG ETTS L +AL L+K+P V Sbjct: 255 DDLLTHMLNGKDPETGEP---LDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVL 311 Query: 321 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRN-Y 379 K EE RV+ + P + + Y V++E R P + D Y Sbjct: 312 QKAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAP-AFSLYAKEDTVLGGEY 369 Query: 380 LIPKGTTILTSLTSVLHDNKEF-PNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGE 438 + KG ++ + + D + + E F P F E + + F PF G+R C+G+ Sbjct: 370 PLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERF--ENPSAIPQHAFKPFGNGQRACIGQ 427 Query: 439 GLARMELFLFLTFILQNFNLKS 460 A E L L +L++F+ + Sbjct: 428 QFALHEATLVLGMMLKHFDFED 449 >3WVS-A nrPDB Length = 401 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 77/420 (18%), Positives = 144/420 (34%), Gaps = 77/420 (18%) Query: 71 LERMVVLHGYEVVKEAL--IDLGEEFSGRGHFPLAERAN-RGFGIVFSNGKRWKEIRRFS 127 E + YE + L S P A + N + + + +RR Sbjct: 46 GEPAWLATRYEDARLVLGDARFSRALSEEHDPPRARKFNAQAKSMFNMDAPDHTRLRRLI 105 Query: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSII---F 183 + + +V + A L++++ K P D P VIC ++ F Sbjct: 106 SKAFTIRRV--EELRPKVHDLAHRLIDDMLA-KGEPADLVADYALPIPTTVICELLGVPF 162 Query: 184 QKR--FDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME 241 + R F L+ E R+ K ++ + ++ Sbjct: 163 EDREKFGRWTDAILSTSTLNPEEGRV------------------------KRMELVGYIG 198 Query: 242 SDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTET 301 I + + P D + +I E ++ Q + T + L+ LL AG ET Sbjct: 199 GIIAARRAQ---------PADDLISGMI----EARDVQDKLTEQELLDHCIGLLIAGHET 245 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL 361 T++ + + LL P+ ++ ++ E + + V E+ R++ L Sbjct: 246 TASQIPSFVYALLDQPQHWKRLLDDPELI------------------PSAVEELFRFVPL 287 Query: 362 IP-TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420 ++ P D++ L+ G +L +L + D F +PE Sbjct: 288 GSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR--------- 338 Query: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480 SN+ + F G C+G LAR+EL L +L+ + + +V G S+P Sbjct: 339 PSNHHIGFGHGIHHCLGAPLARLELQEALRALLERLPTLKVAGDIAWKSEMMVRGPRSMP 398 >3ABB-A nrPDB Length = 408 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 85/429 (19%), Positives = 146/429 (34%), Gaps = 77/429 (17%) Query: 63 PVFTLYFG-LERMVVLHGYEVVKEALIDLGEEFS-GRGHFPLAERANRGFG-----IVFS 115 P+ + ++ G+ + L+D G FP+ R G ++ Sbjct: 38 PLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGV 97 Query: 116 NGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAP 174 + RR M + +FG+ + +I R+Q L++++ K D Sbjct: 98 DDPVHARQRR---MLIPSFGVKRMNAIRPRLQSLVDRLLDDMLA-KGPGADLVSAFALPV 153 Query: 175 CNV-ICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKL 233 +V IC ++ Y D F E R + Sbjct: 154 PSVAICELLG---VPYGDHDF------FEECSRNFVGAATSAEADA-------------- 190 Query: 234 LKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAAD 293 + + + V Q P D + LI + E+ + + +V+ A Sbjct: 191 --AFGELYTYLHGLVGRKQA-----EPEDGLLDELIARQLEEG----DLDHDEVVMIALV 239 Query: 294 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 LL AG ETT + L L++HPE + + V G VV Sbjct: 240 LLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------VVE 281 Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413 E+ R+ + + D++ I G +L S+T + D K + NP++FD R Sbjct: 282 ELLRFTSVSDHIV-RMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR-- 338 Query: 414 DEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVV 473 + + + F G C+G+ LAR EL + L + L P LD P+ Sbjct: 339 -------NARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVP--LDEVPIK 389 Query: 474 NGFASVPPF 482 G + P Sbjct: 390 AGHDAQGPI 398 >5IT1-A nrPDB Length = 399 Score = 190 bits (483), Expect = 9e-49, Method: Composition-based stats. Identities = 70/417 (16%), Positives = 136/417 (32%), Gaps = 69/417 (16%) Query: 71 LERMVVLHGYEVVKEALID----LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRF 126 ++ GYE V+ L D +G + + + +++ + + R+ Sbjct: 42 GHEAWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKL 101 Query: 127 SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKR 186 M +++ +Q ++ + + P D +++ S +F Sbjct: 102 LAKEFTVRRM--QALRPNIQRIVDEHLDAIEA-RGGPVDLVKTFANPVPSMVISDLFGVP 158 Query: 187 FDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILE 246 + + +F + E + + + L + +++ Sbjct: 159 AERR-AEFQEIAEAMMRVDQDAAA-------------------TEAAGMRLGGLLYQLVQ 198 Query: 247 KVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTL 306 + + NP D + LI E F L+ A LL A +TT+ + Sbjct: 199 ERRA--------NPGDDLISALITTEDPDGVIDDMF----LMNAAGTLLIAAHDTTACMI 246 Query: 307 RYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSL 366 LLL P+ A +Q++ + V E+ RY+ + Sbjct: 247 GLGTALLLDRPDQLALLQKDPSLI------------------GNAVEELLRYLTIGQFGA 288 Query: 367 PHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFM 426 T D + I KG ++T L S D +PE FD + + Sbjct: 289 ERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR---------RPAPHL 339 Query: 427 PFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP-KDLDTTP--VVNGFASVP 480 F G C+G+ LAR+EL + + + F L P ++L V G +P Sbjct: 340 AFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHELP 396 >4RM4-A nrPDB Length = 396 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 81/413 (19%), Positives = 145/413 (35%), Gaps = 72/413 (17%) Query: 72 ERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTL 131 ++ + Y+ VK+ + D E FS + G I+ + + +IR Sbjct: 45 NQVWSVFLYDDVKKVVGDK-ELFSSCMPQQTSSI---GNSIINMDPPKHTKIRSVVNKAF 100 Query: 132 RNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIF-----QK 185 M + E R+QE L+++ + D P VI ++ + Sbjct: 101 TPRVM--KQWEPRIQEITDELIQKFQGRSE--FDLVHDFSYPLPVIVISELLGVPSAHME 156 Query: 186 RFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDIL 245 +F ++ + +E F +K + LA + I+ Sbjct: 157 QFKAWSDLLVSTPKDKSEEAE-----------------KAFLEERDKCEEELAAFFAGII 199 Query: 246 EKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTT 305 E+ + N P I L++ E+ + + + E L+ LL AG ETT+ Sbjct: 200 EEKR--------NKPEQDIISILVEAEETGE----KLSGEELIPFCTLLLVAGNETTTNL 247 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTS 365 + A+ +L+ P V +++ E V E R+ P Sbjct: 248 ISNAMYSILETPGVYEELRSHPE------------------LMPQAVEEALRFRAPAP-V 288 Query: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425 L D + +LI +G +L + S D +F P MFD R N Sbjct: 289 LRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR---------HPNPH 339 Query: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFAS 478 + F G C+G LAR+E + LT ++ F + ++ + V+ G S Sbjct: 340 IAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENS-VIYGLKS 391 >4YZR-A nrPDB Length = 405 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 72/434 (16%), Positives = 137/434 (31%), Gaps = 81/434 (18%) Query: 59 KIYGPVFTLYFGLERMVVLHGYEVVKEALIDLG--EEFSGRGHFPLAERANRGFGIVF-- 114 K +G + ++ Y+ L D + + + N I F Sbjct: 36 KRFGATY-------PAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVS 88 Query: 115 -----SNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 + +R + ++ +++ A L++E+ K + Sbjct: 89 DHMLAKDTPDHTRLRSLVHQAFTPRTI--ENLRGSIEQIAEQLLDEMEKENKADI-MKSF 145 Query: 170 LGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGT 229 P VI ++ + D Q ++D G Sbjct: 146 ASPLPFIVISELMGIPKEDRS-----------------------QFQIWTNAMVDTSEGN 182 Query: 230 HNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVI 289 + L + I + + + + P+D + L+ E S+ + + L Sbjct: 183 RELTNQALREFKDYIAKLIHDRRI-----KPKDDLISKLVHAE----ENGSKLSEKELYS 233 Query: 290 TAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTD 349 L+ AG ETT L L LL+H + K++++ E + Sbjct: 234 MLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT----------------- 276 Query: 350 AVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDP 409 V E+ RY + D ++ + I +G I + S D F NPE+ + Sbjct: 277 -AVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNI 335 Query: 410 RHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN-LKSLIDPKDLD 468 N + F G C+G LAR+E + +L+ F ++ + P D+ Sbjct: 336 NR---------SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQ 386 Query: 469 TTPVV--NGFASVP 480 V G S+P Sbjct: 387 WRKNVFLRGLESLP 400 >3ABA-A nrPDB Length = 403 Score = 187 bits (475), Expect = 9e-48, Method: Composition-based stats. Identities = 71/417 (17%), Positives = 135/417 (32%), Gaps = 69/417 (16%) Query: 71 LERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAE---RANRGFGIVFSNGKRWKEIRRFS 127 ++ GYE V+ L FS + L + G + E Sbjct: 42 GHEAWLVTGYEEVRALL--RDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDR 99 Query: 128 LMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKR 186 + + F + + +++ +Q ++ + + P D A +++ S +F Sbjct: 100 KLLAKEFTVRRMQALRPNIQRIVDEHLDAIEA-RGGPVDLVKTFANAVPSMVISDLFGVP 158 Query: 187 FDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILE 246 + + +F ++ E + + + L + +++ Sbjct: 159 VERR-AEFQDIAEAMMRVDQDAAA-------------------TEAAGMRLGGLLYQLVQ 198 Query: 247 KVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTL 306 + + NP D + LI E F L+ A LL A +TT+ + Sbjct: 199 ERRA--------NPGDDLISALITTEDPDGVVDDMF----LMNAAGTLLIAAHDTTACMI 246 Query: 307 RYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSL 366 LLL P+ A ++E+ V V E+ RY+ + Sbjct: 247 GLGTALLLDSPDQLALLREDPSLV------------------GNAVEELLRYLTIGQFGG 288 Query: 367 PHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFM 426 T DV+ I KG ++ + + D PE FD + + Sbjct: 289 ERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR---------RPAPHL 339 Query: 427 PFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP-KDLDTTP--VVNGFASVP 480 F G C+G+ LAR+EL + + + L P ++L V G +P Sbjct: 340 AFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGVHELP 396 >5Y1I-A nrPDB Length = 403 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 81/409 (19%), Positives = 140/409 (34%), Gaps = 70/409 (17%) Query: 66 TLYFGLERMVVLHGYEVVKEALIDLGEEFSG-RGHFPLAERANRGFGIV---FS--NGKR 119 ++ G V+ + + L D G R +P + + F+ + Sbjct: 37 RIWDGSTP-WVVTRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPE 95 Query: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVI 178 IRR TL ++ +Q+ L++ + P D L P VI Sbjct: 96 HGRIRRMV--TLPFTARRIEAMRPAIQKITDELIDGMLAGP-KPVDLVEALALPVPVRVI 152 Query: 179 CSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLA 238 C ++ Y+D++FL Q NN D G K A Sbjct: 153 CEMLG---VPYEDREFL------------------QQNNNAMIYRDTAQGDAQKAAIAQA 191 Query: 239 FMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAG 298 +++ + + D I L Q + E T ++ LLGAG Sbjct: 192 MYLKELV--------GTKLGDRGDDILSDLAV-----QVEAGEITQDDAAGIGMMLLGAG 238 Query: 299 TETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRY 358 ETT+ + L LL++PE A+V++ + V N V E+ RY Sbjct: 239 HETTANMIALGTLALLENPEQLAEVRDSDDPKVIVN----------------TVEELLRY 282 Query: 359 IDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPN-PEMFDPRHFLDEGG 417 + + ++ D++ +I G I+ L + D +P P+ D Sbjct: 283 LTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR------ 336 Query: 418 NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466 + + F G C+G LAR+EL + + +L+ +L D Sbjct: 337 --ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLD 383 >6FSH-A nrPDB Length = 398 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 80/417 (19%), Positives = 140/417 (33%), Gaps = 78/417 (18%) Query: 62 GPVFTLYFGL----ERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSN- 116 G + + G E + G+ VV++ L D ++FS R + + G GI Sbjct: 26 GTLTKISIGSGADAETTWLAAGHAVVRQVLGDH-QQFSTRRRWDPRDEI-GGKGIFRPRE 83 Query: 117 --GKRWK----EIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 G E R + F + R + R++E ++ + + P D + Sbjct: 84 LVGNLMDYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAM-EQAGPPADLIEL 142 Query: 170 L-GCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG 228 P V+C +I R D M+ + ++ + Sbjct: 143 FADEVPGAVLCELIGVPRDDRDM-----FMKLCHGHLDASLS------------------ 179 Query: 229 THNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLV 288 + + +K + +M +D D F+ + E + T E L Sbjct: 180 ---------QKRRAALGDKFSRYLLAMIARERKDPGDGFIGSIVAEHGD---TITDEELR 227 Query: 289 ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT 348 L+ AG + S + +L LL+HPE A ++ G Sbjct: 228 GVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALR------------------GDDQSA 269 Query: 349 DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD 408 D V E+ RY+ + P DV + +I +G T+L SL D P+ + D Sbjct: 270 DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLD 329 Query: 409 PRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPK 465 + + F G C+G L R++L + T + + F L DP Sbjct: 330 ---------VTRTPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPA 377 >3SN5-A nrPDB Length = 491 Score = 186 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 90/499 (18%), Positives = 164/499 (32%), Gaps = 68/499 (13%) Query: 19 IWRQSSGRGKL---PPGPTPL-PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERM 74 + +++S R + PP L P +G LQ + + L + +G VFT + + Sbjct: 1 MAKKTSSRRRQTGEPPLENGLIPYLGCALQFGA-NPLEFLRANQRKHGHVFTCKLMGKYV 59 Query: 75 VVLHGYEVVKEALIDLGEEFSGRG-HFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 133 + + L G+ F + HF L+ +A I +G T Sbjct: 60 HFITNPLSYHKVLC-HGKYFDWKKFHFALSAKAFGHRSIDPMDG----------NTTENI 108 Query: 134 FGMGKRSIEDR-VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQ 192 ++++ + ++E L++ P + S ++ F+ Sbjct: 109 NDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAG-- 166 Query: 193 QFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP----GTHNKLLKNLAFMESDILEKV 248 +L + + + +NF FP G + + + E + Sbjct: 167 -YLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESL 225 Query: 249 KEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRY 308 + E++ LI + + S F T +L A T + Sbjct: 226 RH--ENLQKRES----ISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 279 Query: 309 ALLLLLKHPEVTAKVQEEIERVV----------GRNRSPCMQDRGHMPYTDAVVHEVQRY 358 +L ++++PE EE++R + G + +P D+++ E R Sbjct: 280 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 339 Query: 359 IDLIPTSLPHAVTCDVKF----RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLD 414 D +Y I K I + D + +P+P F +LD Sbjct: 340 SSASLNI--RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLD 397 Query: 415 EGGNFKK---------SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPK 465 E G K Y+MPF +G IC G A E+ FL +L F L+ Sbjct: 398 ENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE------ 451 Query: 466 DLDTTPVVNGFASVPPFYQ 484 ++ G A PP Q Sbjct: 452 ------LIEGQAKCPPLDQ 464 >4GGV-A nrPDB Length = 418 Score = 185 bits (470), Expect = 4e-47, Method: Composition-based stats. Identities = 78/412 (18%), Positives = 146/412 (35%), Gaps = 59/412 (14%) Query: 74 MVVLHGYEVVKEALIDLGEEFSGRGHF--PLAERANRGFGIVFSNGKRWKEIRRFSLMTL 131 + ++GY + L D S H + + + R ++ R+ Sbjct: 55 VWNVYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYRQLVSRAF 114 Query: 132 RNFGMGKRSIEDRVQEEARCLVEE--LRKTKASPCDPTFILGCAPCNVICSIIFQKRFDY 189 + +E RV + R L++ + D + L P VI ++ D Sbjct: 115 TPRLVAD--METRVADITRELLDAVDGKPEIEIAADLAYPL---PVIVIAELLGVPAGDR 169 Query: 190 KDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVK 249 L +K ++I + + + + G + +++ +L+ + Sbjct: 170 D------LFKKWADDIIEGFSGFSFLDTS---------GQGEQDVRDATERLRPLLDYMA 214 Query: 250 EHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYA 309 H + PR+ + L++ E + + T +V A LL G TT+ TL Sbjct: 215 GH-VTERRRTPREDLLTHLVQAEVDGE----RLTDNEIVNVANILLVTGHITTTMTLGNT 269 Query: 310 LLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHA 369 +L L PEV AKV+ + V G + E R + +L Sbjct: 270 VLCLDADPEVAAKVRADRSLVPG------------------AIEEALRVLSP-SAALARG 310 Query: 370 VTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFS 429 + +V+ +IPK ++ L + D ++F +PE++DP N F Sbjct: 311 TSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR---------DPNPHFGFG 361 Query: 430 AGKRICVGEGLARMELFLFLTFILQNFNLKS--LIDPKDLDTTPVVNGFASV 479 G C+G LAR+E + L + F + P TP + G ++ Sbjct: 362 RGIHFCLGAPLARLEGRVALNALFDRFPVLRTDPAKPPTFFPTPDMIGVNTL 413 >6GMF-A nrPDB Length = 397 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 80/419 (19%), Positives = 146/419 (34%), Gaps = 66/419 (15%) Query: 68 YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERA-----NRGFGIVFSNGKRWKE 122 + + + Y+ V L D + FS RG R + IV + R + Sbjct: 31 RLQPQGFMAVGRYQDVARVLHD-AKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGK 89 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 +R + + +E R+++ A LV+ LR + P VI ++ Sbjct: 90 LRTLVTKAFTPRTVAQ--LEPRIRDIAHELVDGLRGKSTFEAT-VEVTVPMPMIVIAEML 146 Query: 183 FQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMES 242 D F + + ++ +V G +L ++ + Sbjct: 147 GVAPERRAD--FKRWSDDMVGSLALVRV-----------------GNAAQLERSTQEFYA 187 Query: 243 DILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETT 302 E ++E + + L+ E + + + T ++ A LL AG ETT Sbjct: 188 YFSEVLEERRREPRE-----DLISQLLAAEVDGE----KLTAGEVLSFANTLLIAGNETT 238 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLI 362 ++ + AL+ L HPE A Q ++ V AVV EV RY Sbjct: 239 TSLIGNALVALTDHPEQLAAAQADLSLV------------------PAVVEEVLRYESPA 280 Query: 363 PTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS 422 + DV+ + IP + +L L S D FP+P+ FD + Sbjct: 281 QC-IFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHR---------DT 330 Query: 423 NYFMPFSAGKRICVGEGLARMELFLFLTFILQNF-NLKSLIDPKDLDTTPVVNGFASVP 480 + F C+G LAR+E + L +L +++ + + + +++P Sbjct: 331 KGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARLGDIQRVSQEVSWSPSFFIRSPSTLP 389 >5FOI-A nrPDB Length = 408 Score = 184 bits (468), Expect = 6e-47, Method: Composition-based stats. Identities = 83/402 (20%), Positives = 139/402 (34%), Gaps = 74/402 (18%) Query: 71 LERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFG---IVFSNGKRWKEIRRF- 126 ++ YE V+ L+D L+E G G ++ + +RR Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 127 -SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFQ 184 S ++R + IE V L+ P D L VIC ++ Sbjct: 115 ISAFSVRQVETMRPEIEKIVDGILDRLL-----ALEPPVDILTHLALPMSTQVICHLLG- 168 Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244 Y+D++F E + S P + P +I L + Sbjct: 169 --VPYEDREF------FQERSELASRP--NDDRSMPALI------------ELVEYLDGL 206 Query: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304 + H D L+ ++ + E T + LV A LL AG ET++ Sbjct: 207 VRTKTAHP------------DTGLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSAN 254 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364 + ++L LL+HPE A+++E+ E V E+ RY + Sbjct: 255 QVTLSVLTLLRHPETAAELREQPE------------------LMPNAVDELLRYHSIAD- 295 Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424 L A T D+ ++ I G ++ L+S HD F FD + + Sbjct: 296 GLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR---------PARH 346 Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466 + F G C+G+ LAR+E+ + L + + L D Sbjct: 347 HVAFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEPD 388 >5YSW-A nrPDB Length = 441 Score = 184 bits (468), Expect = 6e-47, Method: Composition-based stats. Identities = 81/449 (18%), Positives = 153/449 (34%), Gaps = 82/449 (18%) Query: 49 DVSKSLTNLSKIYGPVFTLYFG-LERMVVLHGYEVVKEALIDLG------------EEFS 95 V +L +S+ GPV + ++ GYE + L D +E S Sbjct: 52 HVPPALVAVSER-GPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELS 110 Query: 96 GRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEE 155 L + R + + R+ + R + R+ E V+ Sbjct: 111 PEFRERLRDDKARAGSFINMDPPEHTRYRKLLTGQFTVRRI--RELGARIDEIVAGRVDA 168 Query: 156 LRKTKASPCDPTFILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQ 214 + + D AP +IC ++ R++ + + L N Sbjct: 169 MLAG-GTTADLMTEFAFPAPSLMICELL-GVRYEDRAEFQQRASALLQMN---------- 216 Query: 215 ICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKE 274 + +KN + + + V + + NP I LI Sbjct: 217 -------------APVAEAVKNADALRAFMQALVTDKRA-----NPAGDIISGLIH---- 254 Query: 275 KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRN 334 T + L+ A LL AG +TT++ L + +LL+ P A ++++ R+ Sbjct: 255 HAGADPALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD-- 312 Query: 335 RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSV 394 V E+ RY+ ++ + D++F IP G+T++ S+ + Sbjct: 313 ----------------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVAT 356 Query: 395 LHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQ 454 D + +P+P++ + + F G C+G+ LARME+ +L+ Sbjct: 357 NRDARHWPDPDL----------DLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLR 406 Query: 455 NFNLKSLIDPKD---LDTTPVVNGFASVP 480 L P + L + G S+P Sbjct: 407 RLPNVRLAVPPEEVPLRNDMLTYGVHSLP 435 >4MM0-A nrPDB Length = 399 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 86/423 (20%), Positives = 147/423 (34%), Gaps = 83/423 (19%) Query: 71 LERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRG--FGIVFSNGKRWKEIRRFSL 128 + ++ YE V+ L D FS R P A R ++ ++ +RR Sbjct: 44 GDPGFLVTRYEDVRFVLSD--PRFSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRR--- 98 Query: 129 MTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFQ-- 184 + R+F + + R++E A L++E+ K K +P D L P VIC ++ Sbjct: 99 LLSRDFTARRIERMRPRLEEIAEGLLDEMEK-KGAPADIVESLAVPFPITVICELLGVPM 157 Query: 185 ---KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME 241 RF ++L E+ Sbjct: 158 VDVARFRGWADTMVSLTGYSMEDWTAA--------------------------------- 184 Query: 242 SDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTET 301 D LE + + NP + L+ E +E T ++ + LL AG E Sbjct: 185 RDALESYLDGLVAAKRENPGSDLLSALVATAAE----DNELTDHDVRSLSLILLLAGYEP 240 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL 361 S L ++L LL+ P+ A+++ + + V E+ RY Sbjct: 241 ASNQLGSSVLTLLRFPDRLAELRRDPG------------------LLPSAVEELMRYAPA 282 Query: 362 IPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK 421 +L DV + IP + +L S + D + F +P Sbjct: 283 GDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR---------P 333 Query: 422 SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLI-DPKDLDTT---PVVNGFA 477 N G C+G LAR+EL + + +L+ F +L D L + +++GFA Sbjct: 334 DNQHTALGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPGSMLSGFA 393 Query: 478 SVP 480 +P Sbjct: 394 EIP 396 >1ODO-A nrPDB Length = 408 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 74/433 (17%), Positives = 134/433 (30%), Gaps = 72/433 (16%) Query: 62 GPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVF------- 114 GP + + + ++K+ L R H+P + + Sbjct: 28 GPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENM 87 Query: 115 --SNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT-KASPCDPTFILG 171 + G +++RR ++ V+ LV+ L + P D L Sbjct: 88 FTAYGPNHRKLRRLVAPAFS--ARRVDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQELA 145 Query: 172 CAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHN 231 + + D +D ++ Sbjct: 146 YPLPIAVIGHLMGVPQDRRD----GFRALVDGVFDTTLD-------------------QA 182 Query: 232 KLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITA 291 + N A + + + + + + P D + LI ++ + + E L T Sbjct: 183 EAQANTARLYEVLDQLIAAKRAT-----PGDDMTSLLIAARDDEGD-GDRLSPEELRDTL 236 Query: 292 ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAV 351 ++ AG ETT + A+ LL P+ A V++ G + + D V Sbjct: 237 LLMISAGYETTVNVIDQAVHTLLTRPDQLALVRK-----------------GEVTWAD-V 278 Query: 352 VHEVQRYIDLIPTSLPHAVTCDVKF-RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPR 410 V E R+ + D+ I +G IL S + + + FD Sbjct: 279 VEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDAT 338 Query: 411 HFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP-KDLDT 469 + E + F G C+G LARME+ L L + F L DP ++L Sbjct: 339 RTVKE---------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAEELPP 389 Query: 470 TP--VVNGFASVP 480 P + NG +P Sbjct: 390 VPSLISNGHQRLP 402 >6GK6-A nrPDB Length = 411 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 74/416 (17%), Positives = 133/416 (31%), Gaps = 80/416 (19%) Query: 76 VLHGYEVVKEALIDLGEEFSGRGHFPLAERA-NRGFGIVFSNGKRWKEIRRFSLMTLRNF 134 +L ++++ + R +FPL++R ++ ++ +R Sbjct: 56 LLKDPRLIRDF--RKLPDEVRRRYFPLSDRTTFMDQHMLDADPPDHTRLRAIVQRAFSP- 112 Query: 135 GMGKRSIEDRVQEEARCLVEEL--RKTKASPCDPTFILGCAPCNVICSIIF-----QKRF 187 + R+QE A L++ + R+ D F L P VI ++ + RF Sbjct: 113 -RMMEGLRPRIQEIADGLIDAVIDRRRMELIADFAFPL---PTAVIAELLGLPVEDRGRF 168 Query: 188 DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK 247 + L P + ++ + + Sbjct: 169 RRWTKILLA------------------------------PAKDREFVERAQPVVEEFAAY 198 Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 + ++ D I L+ E+E + + L LL AG ETT + Sbjct: 199 FRALADARRKAPRDDLISGLLLAEEQEHK-----LSPAELSSMVFLLLVAGHETTVHLIA 253 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP 367 +LLLL HP ++ E+ V + V E R S Sbjct: 254 SGMLLLLSHPAERRRLDEDPGLV------------------GSAVEEALRCEGPAELSTI 295 Query: 368 HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMP 427 D++ +P G + L + D + FP+P+ FD N + Sbjct: 296 RWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGR---------SPNRHIG 346 Query: 428 FSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD---LDTTPVVNGFASVP 480 F G C+G LAR+E + + +L+ L P + G A+VP Sbjct: 347 FGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIELATSTRDIVWSEWPTIRGPAAVP 402 >1GWI-A nrPDB Length = 411 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 87/428 (20%), Positives = 138/428 (32%), Gaps = 77/428 (17%) Query: 62 GPVFTLYF-GLERMVVLHGYEVVKEALIDLGEEFS-------GRGHFP----LAERANRG 109 GP+ + G + + + K L D RG P L AN G Sbjct: 30 GPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPG 89 Query: 110 FGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 ++ +G + +R L + + R+ E L++EL D Sbjct: 90 RSMLTVDGAEHRRLRTLVAQALTVRRV--EHMRGRITELTDRLLDELPAD-GGVVDLKAA 146 Query: 170 LGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG 228 P V+ ++ ++ L ++ L E TP P Sbjct: 147 FAYPLPMYVVADLMG------IEEARLPRLKVLFEKFFSTQTP---------------PE 185 Query: 229 THNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLV 288 L LA + +D + + P D + LI+ T +V Sbjct: 186 EVVATLTELASIMTDTVAAKRA--------APGDDLTSALIQAS----ENGDHLTDAEIV 233 Query: 289 ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT 348 T ++ AG ETT + + A++ L HPE A V + G Sbjct: 234 STLQLMVAAGHETTISLIVNAVVNLSTHPEQRALV------LSGEAEW------------ 275 Query: 349 DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEMF 407 AVV E R+ L DV + +IP G ++ S ++ D + P + F Sbjct: 276 SAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRF 335 Query: 408 DPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP-KD 466 D N + F G +C G L+RME + L + F L P + Sbjct: 336 DLTRT--------SGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAE 387 Query: 467 LDTTPVVN 474 L PVV Sbjct: 388 LRNKPVVT 395 >5XW2-A nrPDB Length = 419 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 78/412 (18%), Positives = 145/412 (35%), Gaps = 57/412 (13%) Query: 74 MVVLHGYEVVKEALIDLG--EEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTL 131 ++GY E L D G R A+ A ++ ++ +E+R+ Sbjct: 54 AWNVYGYAEAIEVLGDPGTFSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSHAF 113 Query: 132 RNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFQKRFDYK 190 + +E R+ + L++ + D L P V+ ++ D Sbjct: 114 TPKVVA--ELEPRITALTQELLDAVADR--DTFDLMTALAYPLPVTVVAELLSIPSADR- 168 Query: 191 DQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKE 250 F M ++ ++ VS ++ P ++ + +LE ++E Sbjct: 169 -HLFEGWMTEIVHSLGDVS-------------MEDAPEDQERIFEAGMAPMRKMLEYLRE 214 Query: 251 HQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYAL 310 H PR + LI+ E + + T ++V A LL AG TT+ + + Sbjct: 215 HAAECR-RRPRGDLMGKLIEAEVDGR----RLTDNHIVNFAKMLLIAGYLTTTMLIGNTV 269 Query: 311 LLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 370 L L +PE A+V+ + + G + E R++ + + A Sbjct: 270 LCLDSYPEQAARVRADRSLIPGL------------------LEESMRFLSPV-AATYRAT 310 Query: 371 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSA 430 T DV+ + ++ + D ++F PE+FD + N + F Sbjct: 311 TRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFD---------MTRGPNPHLGFGR 361 Query: 431 GKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV--VNGFASVP 480 G C+G LARME + L +L F + P G +S+P Sbjct: 362 GIHFCLGGPLARMEGRVALDHLLDRFPELYTDPERPPTFMPGFDTTGVSSLP 413 >3R9C-A nrPDB Length = 418 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 64/390 (16%), Positives = 125/390 (32%), Gaps = 54/390 (13%) Query: 90 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149 F + R +F + +R + + +E + Sbjct: 75 KSTIFQRQLAAETQPRPQGPASFLFLDPPDHTRLRGLVSKAFAPRVI--KRLEPEITALV 132 Query: 150 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVS 209 L++ + + + D + P VIC ++ D +F L + Sbjct: 133 DQLLDAVDGPEFNLID--NLAYPLPVAVICRLLGVPIEDE--PKFSRASALLAAALDPFL 188 Query: 210 TPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLI 269 + + F ++ +K ++ + + E + + P + + L+ Sbjct: 189 ALTGETSDLF-----------DEQMKAGMWLRDYLRALIDERRRT-----PGEDLMSGLV 232 Query: 270 KMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 +E + T + ++ T LL AG ETT + A L +L+ P A + + R Sbjct: 233 AVE----ESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSR 288 Query: 330 VVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILT 389 AV+ E RY + + D+ + +PKG T+L Sbjct: 289 ------------------ASAVIEETMRYDPPVQL-VSRYAGDDLTIGTHTVPKGDTMLL 329 Query: 390 SLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFL 449 L + D P+ FDP + F G C+G LAR+E + L Sbjct: 330 LLAAAHRDPTIVGAPDRFDPDR---------AQIRHLGFGKGAHFCLGAPLARLEATVAL 380 Query: 450 TFILQNFNLKSLIDPKDLDTTPVVNGFASV 479 + F L + + G +++ Sbjct: 381 PALAARFPEARLSGEPEYKRNLTLRGMSTL 410 >1LG9-A nrPDB Length = 398 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 72/439 (16%), Positives = 149/439 (33%), Gaps = 86/439 (19%) Query: 43 LQIDIKDVSKSLTNLSKIYGPVFTLYFGL----ERMVVLHGYEVVKEALIDLGEEFSGRG 98 L I + + + L+ G + + G E + + VV++ + D ++FS R Sbjct: 9 LHIRRQGLDPADELLAA--GALTRVTIGSGADAETHWMATAHAVVRQVMGDH-QQFSTRR 65 Query: 99 HFPLAERANRGFGI----------VFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQE 147 + + G GI + + +RR F + K + + +++ Sbjct: 66 RWDPRDEI-GGKGIFRPRELVGNLMDYDPPEHTRLRR---KLTPGFTLRKMQRMAPYIEQ 121 Query: 148 EARCLVEELRKTKASPCDPT-FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIR 206 ++E+ + SP D F+ P V+C ++ R D M+ + ++ Sbjct: 122 IVNDRLDEMERA-GSPADLIAFVADKVPGAVLCELVGVPRDDRDM-----FMKLCHGHLD 175 Query: 207 IVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDC 266 + + + +K + +M ++ + Sbjct: 176 ASLS---------------------------QKRRAALGDKFSRYLLAMIARERKEPGEG 208 Query: 267 FLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEE 326 + + E + + T E L ++ AG + S + +L +L+HPE + + Sbjct: 209 MIGAVVAEYGD---DATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGD 265 Query: 327 IERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTT 386 + V E+ RY+ + + P D+ I KG + Sbjct: 266 EQS------------------AQRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDS 307 Query: 387 ILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELF 446 ++ SL + D P+ + D ++ + F G C+G LAR+EL Sbjct: 308 VICSLPAANRDPALAPDVDRLD---------VTREPIPHVAFGHGVHHCLGAALARLELR 358 Query: 447 LFLTFILQNFNLKSLIDPK 465 T + + F L DP Sbjct: 359 TVFTELWRRFPALRLADPA 377 >4TX3-A nrPDB Length = 404 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 81/417 (19%), Positives = 139/417 (33%), Gaps = 78/417 (18%) Query: 62 GPVFTLYFGL----ERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSN- 116 G + + G E + G+ VV++ L D + FS R F + G G+ Sbjct: 32 GTLTKISIGSGADAETTWLAAGHAVVRQVLGDH-KRFSTRRRFDRRDEI-GGTGVFRPRE 89 Query: 117 --GKRWK----EIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 G E R + F + R + R++E ++ + + P D + Sbjct: 90 LVGNLMDYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAM-EQAGPPADLIEL 148 Query: 170 L-GCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPG 228 P V+C +I R DQ ++ + ++ + Sbjct: 149 FADEVPGAVLCELIGVPR---DDQAM--FLQLCHRHLDASLS------------------ 185 Query: 229 THNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLV 288 A + E + +M +D D F+ + E + T E L Sbjct: 186 ---------ARKRAAAGEAFARYLVAMMARERKDPGDGFIGSIVAEHGD---TITDEELR 233 Query: 289 ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT 348 L+ AG + S + +L LL+HPE A ++ G Sbjct: 234 GVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALR------------------GDDQSA 275 Query: 349 DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD 408 D V E+ RY+ + P DV + +I +G T+L SL D P+ + D Sbjct: 276 DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLD 335 Query: 409 PRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPK 465 + + F G C+G L R++L + T + + F L DP Sbjct: 336 ---------VTRTPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPA 383 >4JBT-A nrPDB Length = 410 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 71/429 (16%), Positives = 145/429 (33%), Gaps = 77/429 (17%) Query: 62 GPVFTLYFGLERMVVLHGYEVVKEALIDL-----------GEEFSGRGHFPLAERANRGF 110 GP+ + + + G+ + ++ L D + + +PL + Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 111 GIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASP--CDPTF 168 + +G + +R + L + +++ ++ L+++L + A D Sbjct: 90 SMFTVDGPEHRRLRIKTTQALTRRRL--DALKPTIERYVAELLDDLERAGADGAVVDLKS 147 Query: 169 ILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP 227 + P VI +++ D +Q L + + Sbjct: 148 VFAYPLPMRVISALMGVPSED--QEQLLTWYKAFFSILT--------------------- 184 Query: 228 GTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENL 287 ++ L+ + M E V+ P D + LI + ++ T E + Sbjct: 185 -PQDERLRVIDEMHGYFTEMVRRKTA-----EPGDDLTSALIYAT----DGETPLTEEEV 234 Query: 288 VITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPY 347 + L+ AG ETT + + A+ LL HPE V++ G + + Sbjct: 235 IGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVRD-----------------GEIGW 277 Query: 348 TDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEM 406 + + E R+ + L T D+ + +IP+G ++ S ++ D + + Sbjct: 278 -ETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADD 336 Query: 407 FDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466 FD + + F G IC G LAR+E + L + F P D Sbjct: 337 FDITR--------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRFPHLHPALPLD 388 Query: 467 -LDTTPVVN 474 + PV+ Sbjct: 389 QIPNLPVLT 397 >3TYW-A nrPDB Length = 417 Score = 181 bits (458), Expect = 8e-46, Method: Composition-based stats. Identities = 84/414 (20%), Positives = 146/414 (35%), Gaps = 75/414 (18%) Query: 63 PVFTLYFGLER-MVVLHGYEVVKEALID-LGEEFSGRGHFPLAERANRGFGIVF-----S 115 PV + R V+ Y+ V+E L D R FP + G F + Sbjct: 43 PVARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT 102 Query: 116 NGKRWKEIRRFSL--MTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCA 173 + RR L T+R + +++ RV E ++ P D A Sbjct: 103 DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGML-----AAGGPVDLVSAYANA 157 Query: 174 P-CNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNK 232 +VIC ++ R D ++ + I T + Sbjct: 158 VSTSVICELLGIPRHD------------------------LEFFRDVTRISGSRNSTAEQ 193 Query: 233 LLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAA 292 + + L + + V E +E PRD + L+ T E L+ T Sbjct: 194 VSEALGGLFGLLGGLVAERRE-----EPRDDLISKLV----TDHLVPGNVTTEQLLSTLG 244 Query: 293 DLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVV 352 + AG ETT++ + + LLLL PE+ A+++++ + A V Sbjct: 245 ITINAGRETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAV 286 Query: 353 HEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHF 412 E+ R + + + D++ +P ++ L HD ++F +PE D Sbjct: 287 DELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVD---- 342 Query: 413 LDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466 + N+ + F G CVG+ LAR+EL + L +L+ L +D Sbjct: 343 -----FHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERD 391 >5NWS-A nrPDB Length = 435 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 73/438 (16%), Positives = 138/438 (31%), Gaps = 81/438 (18%) Query: 47 IKDVSKSLTNLSKIYGPVFTLY-FGLERMVVLHGYEVVKEALIDLGEEFSGRGH------ 99 + D L + GPV + + Y+ V+ L D + Sbjct: 33 LADPFTGYGRLRER-GPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGA 91 Query: 100 -----------FPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEE 148 P R I+ S+ +RR + + ++ Sbjct: 92 DPREGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRIL--GLRPGIERI 149 Query: 149 ARCLVEEL--RKTKASPCDPTFILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENI 205 A L+ EL R+ + D VIC ++ D + + Sbjct: 150 ADRLLAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATDLERWR--------EWGG 201 Query: 206 RIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID 265 +VS ++ ++FP +IDY H + + A + D + Sbjct: 202 DLVSMRPERLRHSFPVMIDY---CHRLIEQRRAAL--------------------TDDLL 238 Query: 266 CFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQE 325 LI+ + + + S+ V L+ AG ET++ + LL HP A +++ Sbjct: 239 SELIRAQDDDGGRLSDI---ETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRK 295 Query: 326 EIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGT 385 + VHE+ R+ + + T D++ + +G Sbjct: 296 DPA------------------LLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGD 337 Query: 386 TILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 + L S D + + +P+ D + + F G C+G LAR E Sbjct: 338 AVQLVLVSANFDPRHYSDPDRLDITRHQEGQA-----ENHVGFGHGIHYCLGATLARQEG 392 Query: 446 FLFLTFILQNFNLKSLID 463 + L +L+ + +L D Sbjct: 393 EVALARLLETYPDLALAD 410 >6M7X-A nrPDB Length = 484 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 79/448 (17%), Positives = 151/448 (33%), Gaps = 44/448 (9%) Query: 19 IWRQSSG--RGKLP-------PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYF 69 + +++S R LP PG L ++ + +D+ + + GP+F Sbjct: 1 MAKKTSSVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 60 Query: 70 GLERMVVLHGYEVVKEALIDLGEEFSGR----GHFPLAERANRGFGIVFSNGKRWKEIRR 125 G MV + E V++ L + R + G+ NG W+ R Sbjct: 61 GGAGMVCVMLPEDVEK-LQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNR- 118 Query: 126 FSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPC------DPTFILGCAPCNVIC 179 L + V AR + L+K D + Sbjct: 119 LRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN 178 Query: 180 SIIFQKRF-------DYKDQQFLNLMEKLNE-NIRIVSTPWIQICNNFPTIIDYFPGTHN 231 +F +R FL+ +E + + ++++ P P + H Sbjct: 179 LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWK----EHF 234 Query: 232 KLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITA 291 + + + ++K+ + + L+ E + + + + Sbjct: 235 EAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE---------LSPDAIKANS 285 Query: 292 ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAV 351 +L +TT L L L ++P V +++E + +P A Sbjct: 286 MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAA 345 Query: 352 VHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRH 411 + E R + L + D+ +NY IP GT + L S+ + FP PE ++P+ Sbjct: 346 LKETLRLY-PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 404 Query: 412 FLDEGGNFKKSNYFMPFSAGKRICVGEG 439 +LD G+ + Y +PF G R C+G Sbjct: 405 WLDIRGSGRN-FYHVPFGFGMRQCLGRR 431 >4TRI-A nrPDB Length = 407 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 49/236 (20%), Positives = 80/236 (33%), Gaps = 34/236 (14%) Query: 254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313 + P D + L+ E E Q + + +V +L G ETT TL L Sbjct: 194 TKRRAEPTDDLFSVLVNSEVEGQ----RMSDDEIVFETLLILIGGDETTRHTLSGGTEQL 249 Query: 314 LKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCD 373 L+H + + +++ + E+ R+ + ++ +T D Sbjct: 250 LRHRDQWDALVADVD------------------LLPGAIEEMLRWTSPV-KNMCRTLTAD 290 Query: 374 VKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKR 433 F + G I+ S D F +P+ F N + F G Sbjct: 291 TVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDR---------NPNSHVAFGFGTH 341 Query: 434 ICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489 C+G LAR+EL L +L+ L D + P F S P + F P Sbjct: 342 FCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRP--ANFVSGPESMPVVFTP 395 >3MGX-A nrPDB Length = 415 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 71/375 (18%), Positives = 129/375 (34%), Gaps = 67/375 (17%) Query: 107 NRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDP 166 + G +V S ++ +++R+ L R + +RV+ E ++ R CD Sbjct: 101 SGGRMMVVSEHEQHRKLRKLVGPLLSR--AAARKLAERVRIEVGDVL--GRVLDGEVCDA 156 Query: 167 TFILG-CAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDY 225 +G P V+C I+ D ++L + Sbjct: 157 ATAIGPRIPAAVVCEILGVPAEDED--MLIDLTNHAFGGEDELFDGM------------- 201 Query: 226 FPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIE 285 T + + +++ ++ P D + L+ + TI+ Sbjct: 202 ---TPRQAHTEILVYFDELITARRK--------EPGDDLVSTLVT--------DDDLTID 242 Query: 286 NLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHM 345 ++++ ++L G ETT + A+ L P + +++ V Sbjct: 243 DVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV--------------- 287 Query: 346 PYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPE 405 D VV EV R+ L T DV +P GT ++ L + D EF +P+ Sbjct: 288 ---DTVVEEVLRWTSPAMHVL-RVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPD 343 Query: 406 MFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPK 465 F P K N + F G C+G LAR+EL + L + + + L Sbjct: 344 TFLPGR---------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVSRVDLEREP 394 Query: 466 DLDTTPVVNGFASVP 480 VV G+ +P Sbjct: 395 AWLRAIVVQGYRELP 409 >5LIE-A nrPDB Length = 414 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 74/443 (16%), Positives = 135/443 (30%), Gaps = 68/443 (15%) Query: 49 DVSKSLTNLSKIYGPVF----TLYF-GLERMVVLHGYEVVKEAL---IDLGEEFSGRGHF 100 L + + PV+ T + E + Y E L + G+ F Sbjct: 21 GFPHHLFAIHRREAPVYWHRPTEHTPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRF 80 Query: 101 ---PLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELR 157 L + G + + R IRR L R +ED ++ AR L++ Sbjct: 81 GGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTP--RMIRRVEDDLRRRARGLLD--G 136 Query: 158 KTKASPCDPTFILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQIC 216 +P D + P +IC I+ + F P Sbjct: 137 VEPGAPFDFVVEIAAELPMQMIC-ILLGVPETDRHWLF------------EAVEPGFDFR 183 Query: 217 NNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQ 276 + + + + + + LE + + P D + + + Sbjct: 184 GSRRATM-----PRLNVEDAGSRLYTYALELIAGKRA-----EPADDMLSVVANATIDDP 233 Query: 277 NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRS 336 + + + L + L AG ETT ++ LL L ++P+ ++ + E Sbjct: 234 DAPA-LSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFE-------- 284 Query: 337 PCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLH 396 + E+ R+ P S + V I G ++ S Sbjct: 285 ----------LLPTAIEEIVRWTSPSP-SKRRTASRAVSLGGQPIEAGQKVVVWEGSANR 333 Query: 397 DNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 D F + FD K N + F G C+G LAR+EL + +L F Sbjct: 334 DPSVFDRADEFDITR---------KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 Query: 457 NLKSLIDPKDLDTTPVVNGFASV 479 +++P + + G + Sbjct: 385 GSVRVVEPAEWTRSNRHTGIRHL 407 >5OFQ-A nrPDB Length = 409 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 78/420 (18%), Positives = 147/420 (35%), Gaps = 70/420 (16%) Query: 71 LERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMT 130 + YE VK L FS + R I+ + + ++R Sbjct: 48 SRNCWDVFDYETVKYIL-KNPSLFSSKRAME-----ERQESILMMDPPKHTKLRNLVNKA 101 Query: 131 LRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFIL-GCAPCNVICSIIFQKRFDY 189 + + +E ++E A L++E + D G P VI ++ Sbjct: 102 FTPRAI--QHLEGHIEEIADYLLDE--VSSKEKFDIVEDFAGPLPIIVIAELL------- 150 Query: 190 KDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVK 249 + K + +VS F ++ N+ + L +I+ + + Sbjct: 151 GVPIQDRALFKKYSD-DLVSGAENNSDEAFAKMMQ----KRNEGVIFLQGYFKEIIAERQ 205 Query: 250 EHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYA 309 N ++ + L++ E + + T E ++ LL AG ETT+ + Sbjct: 206 --------QNKQEDLISLLLEAEIDGE----HLTEEEVLGFCILLLVAGNETTTNLITNG 253 Query: 310 LLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHA 369 + + + +V +V+ +I V +V E RY I ++ Sbjct: 254 VRYMTEDVDVQNEVRRDISLV------------------PNLVEETLRYYPPIQ-AIGRI 294 Query: 370 VTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFS 429 DV+ I +G +++ S D+ +F P+ F +K+N + F Sbjct: 295 AAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTF---------VVHRKTNPHVSFG 345 Query: 430 AGKRICVGEGLARMELFLFLTFILQN--FNLKSLIDPKDLDTTPVVNGFASVPPFYQLCF 487 G C+G LARME + T +L+ F+ K +D +P V G Y++ F Sbjct: 346 FGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPID-SPFVFGVKK----YEIAF 400 >4ZGX-A nrPDB Length = 489 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 70/409 (17%), Positives = 139/409 (33%), Gaps = 29/409 (7%) Query: 46 DIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEA-----LIDLGEEFSGRGHF 100 + + + + GP+F G RMV + E V++ L Sbjct: 37 GYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILE--PWV 94 Query: 101 PLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + G+ NG W+ R L + V AR + L+K Sbjct: 95 AYRQHRGHKCGVFLLNGPEWRFNR-LRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKV 153 Query: 161 ASPC------DPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQ 214 D + +F +R + + ++ +Q Sbjct: 154 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 213 Query: 215 ICNNFPTIIDYF-PGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRD---FIDCFLIK 270 + ++ + P + + + +++ + + N P+ + L+K Sbjct: 214 LMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK 273 Query: 271 MEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERV 330 E ++E + + +L +TT+ L L L ++P+V +++E Sbjct: 274 AE---------LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAA 324 Query: 331 VGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTS 390 + +P A + E R + L V+ D+ +NY IP GT + Sbjct: 325 AASISEHPQKATTELPLLRAALKETLRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVF 383 Query: 391 LTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEG 439 L S+ + FP PE ++P+ +LD G+ + + +PF G R C+G Sbjct: 384 LYSLGRNAALFPRPERYNPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRR 431 >4Z5Q-A nrPDB Length = 423 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 74/458 (16%), Positives = 143/458 (31%), Gaps = 80/458 (17%) Query: 31 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYF-GLERMVVLHGYEVVKEALID 89 P P P G+ + ++S+S L + G + E ++ Y+ + L D Sbjct: 33 PAPVAYPFTGS----EGLELSQSYAKLFED-GDPIRVQLPFGEPAWLVTRYDDARFVLTD 87 Query: 90 LG--EEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQE 147 + + P I+ + +R + + + E Sbjct: 88 RRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVSKAFTPRRIESKR--AWIGE 145 Query: 148 EARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF-----QKRFDYKDQQFLNLMEKLN 202 A LV +++ A P VIC ++ + R L+ E + Sbjct: 146 LAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVPEDDRTRLRGWCDAALSTGELTD 205 Query: 203 ENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRD 262 E + +F + YF + VKE + PRD Sbjct: 206 E----------ECVQSFMDLQKYFE------------------DLVKERRA-----EPRD 232 Query: 263 FIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 322 + LI E ++ L+ +L G ETT++ + + +L + E+ + Sbjct: 233 DLTSALI----EARDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTR 288 Query: 323 VQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSL-PHAVTCDVKFRNYLI 381 + + E + A V E+ R++ + P D+ L+ Sbjct: 289 LCADPEAI------------------PAAVEELLRFVPFAANGISPRYALEDMTVGGVLV 330 Query: 382 PKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLA 441 +G ++ ++V D F N + N M F G C+G LA Sbjct: 331 REGEPVIVDTSAVNRDGLVFDNADEVVIDR---------ADNRHMVFGHGAHHCLGAHLA 381 Query: 442 RMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASV 479 R+EL L +++ L + ++ + Sbjct: 382 RVELQEALKALVEGMPGLRLSGDVEWKADMIIRAPRVM 419 >3P3Z-A nrPDB Length = 416 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 65/377 (17%), Positives = 120/377 (31%), Gaps = 59/377 (15%) Query: 106 ANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPC 164 R F + F + RR + F + +++ V+ L+++L + Sbjct: 91 PVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKLPQ---GDF 147 Query: 165 DPTFIL-GCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTII 223 D P V+C ++ DY L+ I N + Sbjct: 148 DFVQHFPHPLPALVMCQLLGFPLEDYDTVGRLS------------------IETNLGLAL 189 Query: 224 DYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFT 283 K+ + L M ++ +++ + P D + +++ + Sbjct: 190 SNDQDILVKVEQGLGRMFDYLVAAIEKRKV-----EPGDDLTSDIVRAFHDG-----VLD 239 Query: 284 IENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRG 343 L A +L AG ETT+ L A+ +HP+ K++E E Sbjct: 240 DYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKENPE--------------- 284 Query: 344 HMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPN 403 V EV R+ +P + D + IP GT + D + F + Sbjct: 285 ---LAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFAD 341 Query: 404 PEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID 463 + FD K+ + F G C+G LAR+EL + + + + Sbjct: 342 ADRFDIT--------VKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLDPPQIAG 393 Query: 464 PKDLDTTPVVNGFASVP 480 V G ++P Sbjct: 394 EITWRHELGVAGPDALP 410 >6M7L-A nrPDB Length = 404 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 81/416 (19%), Positives = 146/416 (35%), Gaps = 80/416 (19%) Query: 62 GPVFTLYF--GLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKR 119 GP+ + G GY+VV+E L + G + ++ + Sbjct: 48 GPLVRIPLEDGSAVHWFALGYDVVREVLGSEKFDKRVIGTHFNHQEMALPGNLLQLDPPE 107 Query: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCD-PTFILGCAPCNVI 178 +RR M +++E RVQ ++ + T P + + G V Sbjct: 108 HTRLRRMVAPAYSVRRM--QALEPRVQAIVDDHLDTMAST-GPPVEFLREVAGPMAARVA 164 Query: 179 CSIIFQKRFDYKDQQFLNL-MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNL 237 C +FL + ++ E IR+ + + G ++L Sbjct: 165 C-------------EFLGIPLDDRGELIRLTA---------------HRGGKRRRVLNGH 196 Query: 238 AFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGA 297 A++ + + RD D L + ++ ++ + E L A ++ + Sbjct: 197 AYL---------AYMRELAARLRRDPGDGMLGMVARDHG---ADISDEELAGLCAVVMNS 244 Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQR 357 E T + L LLLL+HPE A ++E E + V E+ R Sbjct: 245 SVEQTESCLAAGTLLLLEHPEQFALLRERPE------------------LGEQAVEEIVR 286 Query: 358 YIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLH-DNKEFPNPEMFDPRHFLDEG 416 Y+ + P T DV+ +I KG + SL + D + FD Sbjct: 287 YLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITR----- 337 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN-LKSLIDPKDLDTTP 471 K + + F G C+G LARMEL + T ++ F L++ + +++ P Sbjct: 338 ----KESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFPSLRTAVPAEEIRFRP 389 >1CPT-A nrPDB Length = 428 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 76/419 (18%), Positives = 136/419 (32%), Gaps = 62/419 (14%) Query: 67 LYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRG-----FGIVFSNGKRWK 121 + G + + + E L D E + G + + Sbjct: 61 MQIGKQPGLFSNAEGS--EILYDQNNE-------AFMRSISGGCPHVIDSLTSMDPPTHT 111 Query: 122 EIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSI 181 R +L + + R +E+ ++ A+ V+ L CD + Sbjct: 112 AYRGLTLNWFQPASI--RKLEENIRRIAQASVQRLLDFDGE-CDFMTDCALYYPLHVVMT 168 Query: 182 IFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME 241 D + LM KL ++ V P Q D + + +A Sbjct: 169 ALGVPEDDE-----PLMLKLTQDFFGVHEPDEQAVAAPRQSAD---EAARRFHETIATFY 220 Query: 242 SDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTET 301 + + + P+D + L + + ++ V A AG +T Sbjct: 221 DYFNGFTVDRR-----SCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIAT----AGHDT 271 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL 361 TS++ A++ L ++PE A + + + +V E R+ Sbjct: 272 TSSSSGGAIIGLSRNPEQLALAKSDPALI------------------PRLVDEAVRWTAP 313 Query: 362 IPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK 421 + S D + R I +G I+ S S D + F NP+ FD F Sbjct: 314 V-KSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF--------- 363 Query: 422 SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480 N + F G +C+G+ LA++E+ +F +L L P L T V G +VP Sbjct: 364 PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATNFVGGPKNVP 422 >3S79-A nrPDB Length = 503 Score = 171 bits (432), Expect = 8e-43, Method: Composition-based stats. Identities = 86/439 (19%), Positives = 162/439 (36%), Gaps = 27/439 (6%) Query: 31 PGPTPLPVIGNILQIDI---KDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 87 PGP IG ++ + + +++YG ++ E +++ + Sbjct: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSM--FH 105 Query: 88 IDLGEEFSGRGHFPLAERANRG--FGIVFSNGKR-WKEIRRFSLMTLRNFGMGKRSIEDR 144 I +S R L + GI+F+N WK R F + L G G + Sbjct: 106 IMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALS--GPGLVRMVTV 163 Query: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNEN 204 E + ++ L + + + S R + + ++ + Sbjct: 164 CAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA 223 Query: 205 IRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFI 264 + + Y K LK+ + I EK + + DF Sbjct: 224 WQALLIKPDIFFKISWLYKKY--EKSVKDLKDAIEVL--IAEKRRRISTEEKLEECMDFA 279 Query: 265 DCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 ++ ++ + T EN+ ++L A +T S +L + L L+ KHP V + Sbjct: 280 TELILA------EKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAII 333 Query: 325 EEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 384 +EI+ V+G R + D + + ++E RY ++ + A+ DV Y + KG Sbjct: 334 KEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKG 391 Query: 385 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME 444 T I+ ++ + FP P F +F YF PF G R C G+ +A + Sbjct: 392 TNIILNIGRMHRLE-FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVM 446 Query: 445 LFLFLTFILQNFNLKSLID 463 + L +L+ F++K+L Sbjct: 447 MKAILVTLLRRFHVKTLQG 465 >1UED-A nrPDB Length = 406 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 80/441 (18%), Positives = 145/441 (32%), Gaps = 84/441 (19%) Query: 59 KIYGPVFTL------YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHF------PLAERA 106 + +GP+ + G + + HGYEVV+ L D E F+ R F E Sbjct: 34 RAHGPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDH-EHFTTRPQFTQSKSGAHVEAQ 92 Query: 107 NRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCD 165 G I + +R+ M F + + R +E +Q ++ L D Sbjct: 93 FVGQ-ISTYDPPEHTRLRK---MLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAE-GPSAD 147 Query: 166 PTFILGCAP-CNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIID 224 + + +C ++ R D ++F+ + + + R Sbjct: 148 LQGLFADPVGAHALCELLGIPRDD--QREFVRRIRRNADLSR------------------ 187 Query: 225 YFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTI 284 K + + L+ + Q + +P D + ++ ++ T Sbjct: 188 -----GLKARAADSAAFNRYLDNLLARQRA----DPDDGLLGMIV------RDHGDNVTD 232 Query: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344 E L L+ G ET + + + +L LL +P + E E+ Sbjct: 233 EELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEK--------------- 277 Query: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404 + VV+E+ RY+ + P DV LI G +L S+ D P+P Sbjct: 278 ---AERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDP 334 Query: 405 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP 464 ++ D + F G CVG LAR L + + + F L P Sbjct: 335 DVLDANRAAVSD---------VGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVP 385 Query: 465 KDLDTTPVVNGFASVPPFYQL 485 ++ + F P + Sbjct: 386 --IEEVKYRSAFVDCPDQVPV 404 >6B11-A nrPDB Length = 440 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 73/418 (17%), Positives = 140/418 (33%), Gaps = 74/418 (17%) Query: 71 LERMVVLHGYEVVKEALID-LGEEFSGRGHF--PLAERANRGFGIVFSNGKRWKEIRRFS 127 + ++ + V+ L D + P A ++ + +R Sbjct: 86 GAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALR--- 142 Query: 128 LMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFQK 185 + FG+ + R + V++ L+++L + D VIC ++ Sbjct: 143 GHFIPEFGLRRVRELRPSVEQIVTGLLDDLTA-RGDEADLLADFALPMATQVICRLL--- 198 Query: 186 RFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDIL 245 Y+D+ + E+ + R P + L+ L + + Sbjct: 199 DIPYEDRDY--FQERTEQATR--------------------PAAGEEALEALLELRDYLD 236 Query: 246 EKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTT 305 + R+ D L M Q + + +++ A LL AG ETT++ Sbjct: 237 RLISGKTG-------RESGDGMLGSMVA--QARGGGLSHADVLDNAVLLLAAGHETTASM 287 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTS 365 + ++L+LL+HP ++ V E+ RY+ + Sbjct: 288 VTMSVLVLLQHPTAWRELTVNPG------------------LLPGAVDELLRYLSIAD-G 328 Query: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425 L + T D++ + I G ++ L + D F PE FD + Sbjct: 329 LRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR---------SARRH 379 Query: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSL---IDPKDLDTTPVVNGFASVP 480 + F G C+G+ LARMEL + L +L+ + L + V G +P Sbjct: 380 VAFGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSDSAVFGVYELP 437 >2WIO-A nrPDB Length = 431 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 78/421 (18%), Positives = 135/421 (32%), Gaps = 65/421 (15%) Query: 63 PVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKE 122 PV+ +G + + + V+ L D S G I + + Sbjct: 62 PVWQDRYG---VWHVFRHADVQTVLRDTATFSSDPTRVIEGASPTPG-MIHEIDPPEHRA 117 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSI 181 +R+ + +E R+++ R L+ D +L P ++ Sbjct: 118 LRKVVSSAFTPRTISD--LEPRIRDVTRSLL----ADAGESFDLVDVLAFPLPVTIVA-- 169 Query: 182 IFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME 241 + L L +E S + I + PT P ++ L + Sbjct: 170 -----------ELLGLPPMDHEQFGDWSGALVDIQMDDPT----DPALAERIADVLNPLT 214 Query: 242 SDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTET 301 + + + E + +P D + L+ E + + E + LL AG T Sbjct: 215 AYLKARCAERRA-----DPGDDLISRLVLAEVDGRA----LDDEEAANFSTALLLAGHIT 265 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL 361 T+ L + L +HP E+ R+ A+V EV RY Sbjct: 266 TTVLLGNIVRTLDEHPAHWDAAAEDPGRI------------------PAIVEEVLRYRPP 307 Query: 362 IPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK 421 P + T + IP + T + S D+ +P+ FDP Sbjct: 308 FPQ-MQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR-------KSG 359 Query: 422 SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF-NLKSLIDPKDLD-TTPVVNGFASV 479 + F G C+G LAR+E + L I+ F L D + L +V G + Sbjct: 360 GAAQLSFGHGVHFCLGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHL 419 Query: 480 P 480 P Sbjct: 420 P 420 >5GWE-A nrPDB Length = 405 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 77/460 (16%), Positives = 132/460 (28%), Gaps = 86/460 (18%) Query: 45 IDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSG-------- 96 D+ + + L + +F G V+ Y+ +K D E FS Sbjct: 9 FDMHNPFPAYKELRQEEPVMFDERIGY---WVVTKYDDIKTTF-DDWETFSSENAQAPVR 64 Query: 97 -RGHFPLAERANRGF----GIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARC 151 RG + GF G+ IR + +++E ++ Sbjct: 65 KRGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRY--KALEPDIRAMVID 122 Query: 152 LVEELRKTKASPCDPTFILG------CAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENI 205 VE++ D L + I + + Sbjct: 123 RVEKMLANDQHVGDMVSDLAYDIPTITILTLIGADISMVDTYKRWSDSRAAM-------- 174 Query: 206 RIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID 265 W + + H L ++ H D + Sbjct: 175 -----TWGDLSDEEQI-------PHAHNLVEYWQECQRMVADAHAHG--------GDNLT 214 Query: 266 CFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQE 325 L++ ++E Q E T + LL AG ETT+T + +LL HPE + E Sbjct: 215 ADLVRAQQEGQ----EITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE 270 Query: 326 EIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGT 385 + + A V EV RY I D + I +G Sbjct: 271 NPKLI------------------PAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGD 311 Query: 386 TILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 +L + S D F N E FD + + F G C+G LA+++ Sbjct: 312 GVLLLMGSANRDEARFENGEEFDISR--------ANAREHLSFGFGIHYCLGNMLAKLQA 363 Query: 446 FLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQL 485 + L + + L+ K + ++ VP + Sbjct: 364 KICLEEVTRLVPSLHLVADKAIGFRENLS--FRVPTSVPV 401 >5XJN-A nrPDB Length = 455 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 77/460 (16%), Positives = 132/460 (28%), Gaps = 86/460 (18%) Query: 45 IDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSG-------- 96 D+ + + L + +F G V+ Y+ +K D E FS Sbjct: 59 FDMHNPFPAYKELRQEEPVMFDERIGY---WVVTKYDDIKTTF-DDWETFSSENAQAPVR 114 Query: 97 -RGHFPLAERANRGF----GIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARC 151 RG + GF G+ IR + +++E ++ Sbjct: 115 KRGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRY--KALEPDIRAMVID 172 Query: 152 LVEELRKTKASPCDPTFILG------CAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENI 205 VE++ D L + I + + Sbjct: 173 RVEKMLANDQHVGDMVSDLAYDIPTITILTLIGADISMVDTYKRWSDSRAAM-------- 224 Query: 206 RIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID 265 W + + H L ++ H D + Sbjct: 225 -----TWGDLSDEEQI-------PHAHNLVEYWQECQRMVADAHAHG--------GDNLT 264 Query: 266 CFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQE 325 L++ ++E Q E T + LL AG ETT+T + +LL HPE + E Sbjct: 265 ADLVRAQQEGQ----EITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE 320 Query: 326 EIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGT 385 + + A V EV RY I D + I +G Sbjct: 321 NPKLI------------------PAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGD 361 Query: 386 TILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 +L + S D F N E FD + + F G C+G LA+++ Sbjct: 362 GVLLLMGSANRDEARFENGEEFDISR--------ANAREHLSFGFGIHYCLGNMLAKLQA 413 Query: 446 FLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQL 485 + L + + L+ K + ++ VP + Sbjct: 414 KICLEEVTRLVPSLHLVADKAIGFRENLS--FRVPTSVPV 451 >2XKR-A nrPDB Length = 398 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 70/409 (17%), Positives = 130/409 (31%), Gaps = 77/409 (18%) Query: 89 DLGEEFSG----RGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDR 144 E FS R P ++ + R+ + + E Sbjct: 54 RQPELFSNAGGIRPDQPALP------MMIDMDDPAHLLRRKLVNAGFTRKRVKDK--EAS 105 Query: 145 VQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNE 203 + L++ + + CD L P VI ++ + + ++ Sbjct: 106 IAALCDTLIDAVCERGE--CDFVRDLAAPLPMAVIGDMLGVRPEQRDM-----FLRWSDD 158 Query: 204 NIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDF 263 + +S+ Q +F +D F ++ +A +D P D Sbjct: 159 LVTFLSSHVSQ--EDFQITMDAFAAYNDFTRATIAARRAD----------------PTDD 200 Query: 264 IDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKV 323 + L+ E + + + + LV+ +L G ETT TL LL++ + + Sbjct: 201 LVSVLVSSEVDGE----RLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLL 256 Query: 324 QEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPK 383 Q + + E+ R+ + ++ +T D +F + Sbjct: 257 QRDPS------------------LLPGAIEEMLRWTAPV-KNMCRVLTADTEFHGTALCA 297 Query: 384 GTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARM 443 G ++ S D F PE FD + N + F G C+G LAR+ Sbjct: 298 GEKMMLLFESANFDEAVFCEPEKFDVQR---------NPNSHLAFGFGTHFCLGNQLARL 348 Query: 444 ELFLFLTFILQNFNLKSLIDPK---DLDTTPVVNGFASVPPFYQLCFIP 489 EL L +L+ L+ L V+G S+P + F P Sbjct: 349 ELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMP----VVFTP 393 >4XE3-A nrPDB Length = 407 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 71/444 (15%), Positives = 131/444 (29%), Gaps = 76/444 (17%) Query: 32 GPTPLPVIG----NILQIDIKDVSKSLTNLSKIYGPVFTLYF--GLERMVVLHGYEVVKE 85 GPTP + ++ D + + PV + G ++ + Sbjct: 7 GPTPADAVPAYPFSLPHALDLDPHYAELRRDE---PVSRVRLPYGEGTAWLVTRMSDARI 63 Query: 86 ALIDLG---EEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIE 142 L D + + G++ + +RR + Sbjct: 64 VLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFT--ARRVEEMR 121 Query: 143 DRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKL 201 RV+ L++++ SP D L P VIC ++ D F + + Sbjct: 122 PRVRSLVDSLLDDMVAH-GSPADLVEFLAVPFPVAVICELLGVPLEDRD--LFRTFSDAM 178 Query: 202 NENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPR 261 + R+ + ++ +F +D + R Sbjct: 179 LSSTRLTAAEIQRVQQDFMVYMDGL------------------------------VAQRR 208 Query: 262 DFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTA 321 D L+ + T +V LL AG ET+ + + LLL + Sbjct: 209 DAPTEDLLGALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYE 268 Query: 322 KVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP-HAVTCDVKFRNYL 380 + + V A V E+ RY L+ T DV+ Sbjct: 269 SLVADPALV------------------PAAVEEMLRYTPLVSAGSFVRVATEDVELSTVT 310 Query: 381 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGL 440 + G + S D + F + + D ++ N + F G C+G L Sbjct: 311 VRAGEPCVVHFASANRDEEVFDHADELD---------FHRERNPHIAFGHGAHHCIGAQL 361 Query: 441 ARMELFLFLTFILQNFNLKSLIDP 464 R+EL L+ +++ F L +P Sbjct: 362 GRLELQEALSALVRRFPTLDLAEP 385 >1EHE-A nrPDB Length = 403 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 69/447 (15%), Positives = 130/447 (29%), Gaps = 76/447 (17%) Query: 48 KDVSKSLTNLSKIYGPVFTLYFG-LERMVVLHGYEVVKEALIDLGEEFSG-RGHFPLAER 105 + L PV + ++ ++ V + E+ S R E Sbjct: 16 PEPPAEFAKLRAT-NPVSQVKLFDGSLAWLVTKHKDV--CFVATSEKLSKVRTRQGFPEL 72 Query: 106 ANRGFGIVFS-------NGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRK 158 + G + + R T ++++ +Q L+E++++ Sbjct: 73 SASGKQAAKAKPTFVDMDPPEHMHQRSMVEPTFTP--EAVKNLQPYIQRTVDDLLEQMKQ 130 Query: 159 --TKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQIC 216 P D + I + F D ++L + N Sbjct: 131 KGCANGPVDLVKEFALPVPSYIIYTLLGVPF--NDLEYLTQQNAIRTNGS---------- 178 Query: 217 NNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQ 276 T + + + V++ P+D I L + + Sbjct: 179 -----------STAREASAANQELLDYLAILVEQRLV-----EPKDDIISKLCTEQVKPG 222 Query: 277 NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRS 336 N + V A LL AG T + + L +HP+ A+++ Sbjct: 223 N----IDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQLKANPS-------- 270 Query: 337 PCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLH 396 V E+ RY ++ DV + L+ I+ S S Sbjct: 271 ----------LAPQFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANR 320 Query: 397 DNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 D + F NP+ F+ + F G C+ E LA+ EL + + Q F Sbjct: 321 DEEVFENPDEFNMNRKWPPQDP-------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKF 373 Query: 457 NLKSLIDP-KDLDTTPVVN--GFASVP 480 + P ++ TP+ G +P Sbjct: 374 PDLKVAVPLGKINYTPLNRDVGIVDLP 400 >5Z9I-A nrPDB Length = 398 Score = 167 bits (423), Expect = 9e-42, Method: Composition-based stats. Identities = 69/374 (18%), Positives = 127/374 (33%), Gaps = 53/374 (14%) Query: 113 VFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC 172 ++ + + +R + K +E RV L++ + D Sbjct: 76 AHTDPPKHRRLRGLVDHAFTPSLVAK--MESRVHGIIHELLDGVEGKSQ--FDLVAEFAA 131 Query: 173 APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNK 232 ++ S + + F M+K+ + +P + +K Sbjct: 132 PLPLIMISDLLGVP-ESDRALFRQWMDKMLDGSEKFESP---------ETVLEQEEELHK 181 Query: 233 LLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAA 292 L+ L M E+ E ++ PR+ + L+ E + Q + + A Sbjct: 182 ELELLWEMRDYWHERAAESRKR-----PREDLISQLVHAEVDGQ----KLNDSQISNIAN 232 Query: 293 DLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVV 352 LL G TT+ + +L L + A+V+ DR +P A++ Sbjct: 233 RLLVNGHLTTAMLIANTMLCLDAFSDQDARVRA---------------DRSLVP---ALL 274 Query: 353 HEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHF 412 E RY+ I + A +V+ +IPK +L + D ++F P++FD Sbjct: 275 EESMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFD---- 329 Query: 413 LDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472 + N + F G C+G LARME + +L V Sbjct: 330 -----AGRSPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQV 384 Query: 473 V--NGFASVPPFYQ 484 V +G A++P Q Sbjct: 385 VDASGVATLPVVTQ 398 >3TKT-A nrPDB Length = 450 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 76/424 (17%), Positives = 150/424 (35%), Gaps = 63/424 (14%) Query: 71 LERMVVLHGYEVVKEALID--------LGEEFSGRGHFPLAERANRG-----FGIVFSNG 117 E ++ ++ V +A D F+ R +A+ G +V + Sbjct: 70 HEPFWLVSSFDGVMKASKDNATFLNNPKSTVFTLRVGEMMAKAITGGSPHLVESLVQMDA 129 Query: 118 KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCN 176 + ++RR + + + ++ +++ A ++ + D ++ P + Sbjct: 130 PKHPKLRRLTQDWFMPKNLAR--LDGEIRKIANEAIDRMLGA-GEEGDFMALVAAPYPLH 186 Query: 177 VICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKN 236 V+ I+ D + L L +++ N + D P ++++ Sbjct: 187 VVMQILGVPPEDE--PKMLFLTQQMFGGQDEDM--------NKSGLKDLPPEQISQIVAG 236 Query: 237 LAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLG 296 E+ + NP D + + + + T +ITA+ Sbjct: 237 AVAEF----ERYFAGLAAERRRNPTDDVATVIANAVVDGEPMSDRDTAGYYIITAS---- 288 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQ 356 AG +TTS + A L L + P++ A+V+ DR +P +V E Sbjct: 289 AGHDTTSASSAGAALALARDPDLFARVKA---------------DRNLLP---GIVEEAI 330 Query: 357 RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416 R+ + + D + I G ++ + + HD +FP P FDP Sbjct: 331 RWTTPVQHFM-RTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR----- 384 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGF 476 +N + F AG C+G LAR+E+ + L +L + L + V GF Sbjct: 385 ----PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGF 440 Query: 477 ASVP 480 S+P Sbjct: 441 KSLP 444 >3NC3-A nrPDB Length = 441 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 76/416 (18%), Positives = 135/416 (32%), Gaps = 57/416 (13%) Query: 49 DVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR 108 + + L + PV Y + Y V+ L + F+ + AE R Sbjct: 54 NPYAYFSQLRE-EDPVH--YEESIDSYFISRYHDVRYIL-QHPDIFTTKSLVERAEPVMR 109 Query: 109 GFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLV-EELRKTKASPC-DP 166 G + +GK RR + + G + +++ A L+ L + K+ D Sbjct: 110 GPVLAQMHGKEHSAKRRIVVRSF--IGDALDHLSPLIKQNAENLLAPYLERGKSDLVNDF 167 Query: 167 TFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYF 226 L L ++ +E I W +F T I Sbjct: 168 GKTFAVCVTM----------------DMLGLDKRDHEKISE----WHSGVADFITSISQS 207 Query: 227 PGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIEN 286 P L + ++ +KE + NP + L E E + ++ Sbjct: 208 PEARAHSLWCSEQLSQYLMPVIKERRV-----NPGSDLISILCTSEYEGMA----LSDKD 258 Query: 287 LVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMP 346 ++ ++L A TE TL + LL +PE V + DR +P Sbjct: 259 ILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDV---------------LADRSLVP 303 Query: 347 YTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEM 406 + E RY + +P ++ D I K T + + + D + F P++ Sbjct: 304 ---RAIAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDV 359 Query: 407 FDPRHF-LDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSL 461 F+ L F + + F +G CVG A+ E+ + +L L Sbjct: 360 FNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMRNIRL 415 >5HH3-A nrPDB Length = 397 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 77/418 (18%), Positives = 132/418 (31%), Gaps = 78/418 (18%) Query: 62 GPVFTLYF----GLERMVVLHGYEVVKEALIDLGEEFSGRGHFP-LAERANRGFGIVFSN 116 GP+ TL G + GY+ +++ L ++FS R + A + + Sbjct: 38 GPLTTLGTEESPGGRTAWLATGYDEIRQVL--SSDDFSARLLYGGTAAGITWPGFLTQYD 95 Query: 117 GKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAP-C 175 +RR M + + +V+ + ++ + P D G + Sbjct: 96 PPEHTRLRRMVAPAFAVRRM--QKFQPQVERVVQDSLDAIEAL-GGPVDFVPRFGWSVAT 152 Query: 176 NVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLK 235 C + R D D H + Sbjct: 153 TATCDFLGIPRDDQADLAR---------------------------------SLHASRTE 179 Query: 236 NLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLL 295 + K + M RD D + +E + E T L AA ++ Sbjct: 180 RSGKRRTAAGNKFMTYMNKMTARTRRDPGDDMFGVVVREYGD---EITDAELTGVAAFVM 236 Query: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEV 355 GAG + + L L+ PE A ++E+ + V P D EV Sbjct: 237 GAGADQVARFLAAGAWLMADDPEQFALLREKPDTV------PDWLD------------EV 278 Query: 356 QRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP-EMFDPRHFLD 414 RY+ + P T DV+ ++LI G T+ SL + + FP P + FD Sbjct: 279 IRYLTTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITRVRP 336 Query: 415 EGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP-KDLDTTP 471 E + F G C+G LA + + + F L +P +++ P Sbjct: 337 E---------HLAFGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRLGP 385 >3OO3-A nrPDB Length = 384 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 80/434 (18%), Positives = 141/434 (32%), Gaps = 78/434 (17%) Query: 44 QIDIKDVSKSLTNLSKIYGPVFTL----YFGLERMVVLHGYEVVKEALIDLGEEFSGRGH 99 Q D L K GP+ + ++ G++ V+ L D S R Sbjct: 8 QRLRLDPVPEFEELQKA-GPLHEYDTEPGMDGRKQWLVTGHDEVRAILADHERFSSMRPV 66 Query: 100 FPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT 159 A+RA + + +RR M + R++E +++ ++ Sbjct: 67 DDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARRM--ERLRPRIEEIVEECLDDF-ES 123 Query: 160 KASPCDPTFILG-CAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNN 218 +P D P + C + R DQ L+ M + + R+ Sbjct: 124 VGAPVDFVRHAAWPIPAYIACEFLGVPR---DDQAELSRMIRESRESRL----------- 169 Query: 219 FPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQ 278 + L L + + + + RD D + + +E Sbjct: 170 ----------PRQRTLSGLGIVN---------YTKRLTSGKRRDPGDGMIGVIVREHG-- 208 Query: 279 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 338 +E + E L A L E + L A+LLL+ HP+ A ++E+ E + Sbjct: 209 -AEISDEELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPELI-------- 259 Query: 339 MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 D+ EV R+ ++ P DV+ I G + S+ + Sbjct: 260 ----------DSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAP 309 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 + FD + M F G C+G LAR++L + L ++ F Sbjct: 310 -----GDRFDITR---------EKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRFPS 355 Query: 459 KSLIDP-KDLDTTP 471 L P +DL P Sbjct: 356 LRLAVPEEDLRFKP 369 >6F0B-A nrPDB Length = 395 Score = 164 bits (416), Expect = 7e-41, Method: Composition-based stats. Identities = 76/427 (17%), Positives = 135/427 (31%), Gaps = 71/427 (16%) Query: 63 PVFTLYF-GLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWK 121 PV + V GYE V+ L D FS P + + Sbjct: 28 PVAKVGLWNGTPAHVFSGYEDVRTVLQDRR--FSSDSRRPNFTELTPTLQSQAAAPPFVR 85 Query: 122 ----EIRRFSLMTLRNF-GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN 176 + RR R F + ++E + +++ L +T A P D + Sbjct: 86 TDNPDHRRLRGTIAREFLPKHIELLRPAIREIVQGVLDGLAET-APPQDMLEAFAVPVAS 144 Query: 177 VICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKN 236 + +D+ L + + V + ++ + Sbjct: 145 ATVFRLLG--IPAEDRALLT--RCVKGVVSAVGS----------------EDEGAEVFRT 184 Query: 237 LAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLG 296 L +++ +P + + LI+ Q+ + T + L+ Sbjct: 185 LGEYIGGLVQ------------DPSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIV 232 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQ 356 G +TT++T+ +L+ PE + V E ER+ P V E+ Sbjct: 233 GGYDTTASTISLSLVSYALQPEKFSVVHEHPERI---------------PLL---VEELL 274 Query: 357 RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416 RY + L T DV+ + G ++ +L D FPNP+ D Sbjct: 275 RYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR----- 329 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLI-DPKDLDTTP--VV 473 S + F G CVG+ LAR+EL + +++ L +DL Sbjct: 330 ----PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMAT 385 Query: 474 NGFASVP 480 G +P Sbjct: 386 YGIHELP 392 >5DE9-A nrPDB Length = 410 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 85/478 (17%), Positives = 151/478 (31%), Gaps = 93/478 (19%) Query: 19 IWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYF--GLERMVV 76 + ++ + P P + + D LT L GPV + G + Sbjct: 1 MTEETISQAVPPVRDWP------AVDLPGSDFDPVLTELM-REGPVTRISLPNGEGWAWL 53 Query: 77 LHGYEVVKEALIDLGEEFS-----GRGHFPLAERANRGFG-IVFSNGKRWKEIRRFSLMT 130 + ++ V+ L+ F R LA G + F + +RR Sbjct: 54 VTRHDDVR--LVTNDPRFGREAVMDRQVTRLAPHFRPARGAVGFLDPPDHTRLRRSVAAA 111 Query: 131 LRNFGMGKRSIEDRVQEEARCLVEELRKTK---ASPCDPTF-ILGCAPCNVICSIIFQKR 186 G+ +RV+E +R +++EL P D T +L P VIC ++ Sbjct: 112 FTARGV------ERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICELMGVPA 165 Query: 187 FDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILE 246 D + + + VS + M + + Sbjct: 166 TDRHSMHTWTQLILSSSHGAEVSE------------------------RAKNEMNAYFSD 201 Query: 247 KVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTL 306 + + ++ + + L + E T+ V A L G E + Sbjct: 202 LI-----GLRSDSAGEDVTSLLGAAV-----GRDEITLSEAVGLAVLLQIGG-EAVTNNS 250 Query: 307 RYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL-IPTS 365 LLL PE+ +++ E E + E+ R+I Sbjct: 251 GQMFHLLLSRPELAERLRSEPE------------------IRPRAIDELLRWIPHRNAVG 292 Query: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425 L DV+ + I G + S + D + FP+P+ D N Sbjct: 293 LSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER---------SPNPH 343 Query: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFN-LKSLIDPKDLDTT--PVVNGFASVP 480 + F G C G LAR+E L + +L LK + P+D+ ++ G ++P Sbjct: 344 VSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALP 401 >2FR7-A nrPDB Length = 412 Score = 161 bits (406), Expect = 8e-40, Method: Composition-based stats. Identities = 44/248 (17%), Positives = 85/248 (34%), Gaps = 28/248 (11%) Query: 233 LLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAA 292 + +E+ HQ + R + + E T E + Sbjct: 187 AFGPPNELRQSAIERSAPHQAYVAEQCQRPNLAPGGFGACIHAFSDTGEITPEEAPLLVR 246 Query: 293 DLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVV 352 LL AG +TT + A+ L + P+ A+++ + Sbjct: 247 SLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPS------------------LARNAF 288 Query: 353 HEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHF 412 E R+ + + T DV+ I +G +L L S D + + +P+ +D Sbjct: 289 EEAVRFESPVQ-TFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITR- 346 Query: 413 LDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472 K++ + F +G +CVG+ +AR+E + L + + + P Sbjct: 347 --------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAGPLKRRFNNT 398 Query: 473 VNGFASVP 480 + G S+P Sbjct: 399 LRGLESLP 406 >3A1L-A nrPDB Length = 425 Score = 161 bits (406), Expect = 9e-40, Method: Composition-based stats. Identities = 72/387 (18%), Positives = 133/387 (34%), Gaps = 60/387 (15%) Query: 76 VLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFG---IVFSNGKRWKEIRRFSLMTLR 132 VL + + A + G+ + P RA R +VF + E+R SL+T Sbjct: 59 VLSNRRLGRNARVASGDTDTAPVPIPTEHRALRTVVENWLVFLDPPHHTELR--SLLTTE 116 Query: 133 NFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQ 192 + R+ E A L++ LR + P P VI +++ D+ Sbjct: 117 FSPSIVTGLRPRIAELASALLDRLRAQR-RPDLVEGFAAPLPILVISALLGIPEEDH--- 172 Query: 193 QFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQ 252 W++ + + + Sbjct: 173 ------------------TWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREV 214 Query: 253 ESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLL 312 + ++ L+ + ++ S +++ +V T LL AG ETT+ L A+L Sbjct: 215 DRRGGDD-----RDDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLT 269 Query: 313 LLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC 372 L H +V +++ E T A V E+ RY + ++ Sbjct: 270 LRAHRDVLDELRTTPES------------------TPAAVEELMRYDPPVQ-AVTRWAYE 310 Query: 373 DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK 432 D++ ++ IP+G+ ++ L S D FP+P++ D + + + F G Sbjct: 311 DIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLD---------VHRAAERQVGFGLGI 361 Query: 433 RICVGEGLARMELFLFLTFILQNFNLK 459 C+G LAR E + L +L Sbjct: 362 HYCLGATLARAEAEIGLRALLDGIPAL 388 >6HQG-A nrPDB Length = 425 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 62/395 (15%), Positives = 127/395 (32%), Gaps = 62/395 (15%) Query: 92 EEFSGRGHFPLAERANRGFGIVF--SNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149 E FS L + A+ +F + + R+ + + +E ++E A Sbjct: 80 EVFSSEPTIVLPDPADDFTLPMFIAMDPPKHDVQRKTVQPIVAPNHLAY--LEPIIRERA 137 Query: 150 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVS 209 ++++L + + + + +F F ++D++ L Sbjct: 138 GKILDDLP--IGEEINWVDKVSIELTTMTLATLFD--FPWEDRRKLTF------------ 181 Query: 210 TPWIQICNNFP---TIIDYFPGTHNKLLKN-LAFMESDILEKVKEHQESMDINNPRDFID 265 W + + P + P H L + L + E + P+ + Sbjct: 182 --WSDVATSAPESGILGTTDPEEHENLRRQTLFECVDYFMRLWNERVNA----PPKPDLI 235 Query: 266 CFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQE 325 L E K + E+ + L+ G +TT T+ ++L L ++P+ K++E Sbjct: 236 SMLAHGESTKNMDRMEY-----LGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLRE 290 Query: 326 EIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGT 385 + A+V E R+ + + D + I +G Sbjct: 291 NPGLI------------------PAMVSETIRWQTPLAY-MRRRAKRDFELGGKTIREGD 331 Query: 386 TILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 + S D + P + + + F G CVG LA ++L Sbjct: 332 KVAMWYVSGNRDEEVIDRPNDYWIER--------PRVRQHLSFGFGVHRCVGNRLAELQL 383 Query: 446 FLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480 + IL F ++ P + V G+ +P Sbjct: 384 KIIWEEILARFPRLEVVGPPRRVYSSFVKGYEELP 418 >5XNT-A nrPDB Length = 411 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 70/405 (17%), Positives = 129/405 (31%), Gaps = 73/405 (18%) Query: 71 LERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGF--------GIVFSNGKRWKE 122 + YE VK L D + FS I ++ ++ Sbjct: 40 GTDTWNVFKYEDVKRVLSD-YKHFSSVRKRTTISVGTDSEEGSVPDKIKITEADPPEHRK 98 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 R + ++ E R+QE A L+EE+ + + P V+ + Sbjct: 99 RRSLLAAAFTPRSL--QNWEPRIQEIADELIEEMDEETEIDI-VQSLASPLPIIVMSDL- 154 Query: 183 FQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMES 242 + P + F + + + ++ Sbjct: 155 -------------------------MGVPSKDRLLFKKWVDILFLPFDKEKQEEVNELKQ 189 Query: 243 DILEKVKEHQESMDIN---NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGT 299 ++ ++ + + NP D I L+K E + + FT + +V T +LGAG Sbjct: 190 VAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGE----MFTDDEVVRTTMLILGAGV 245 Query: 300 ETTSTTLRYALLLLL-KHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRY 358 ETTS L + LL EV ++ E ++ V V E+ RY Sbjct: 246 ETTSHLLANSFYSLLYDDKEVYQELHENLDLV------------------PQAVEEMLRY 287 Query: 359 IDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN 418 L V D + +G ++ +++ D + F + + ++ Sbjct: 288 R-FNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHRPNNKK-- 344 Query: 419 FKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID 463 + F G C+G LAR+E + LT L+ F + Sbjct: 345 ------HLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAVP 383 >4YT3-A nrPDB Length = 410 Score = 155 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 71/413 (17%), Positives = 133/413 (32%), Gaps = 75/413 (18%) Query: 71 LERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGF--------GIVFSNGKRWKE 122 + YE VK L D + FS I S+ ++ Sbjct: 40 GTDTWNVFKYEDVKRVLSD-YKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRK 98 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT-FILGCAPCNVICSI 181 R + ++ E R+QE A L+ ++ + D + P V+ + Sbjct: 99 RRSLLAAAFTPRSL--QNWEPRIQEIADELIGQM--DGGTEIDIVASLASPLPIIVMADL 154 Query: 182 IFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME 241 + P + F + + + ++ Sbjct: 155 --------------------------MGVPSKDRLLFKKWVDTLFLPFDREKQEEVDKLK 188 Query: 242 SDILEKVKEHQESMDIN---NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAG 298 ++ ++ + + NP D I L+K E + + FT + +V T +LGAG Sbjct: 189 QVAAKEYYQYLYPIVVQKRLNPADDIISDLLKSEVDGE----MFTDDEVVRTTMLILGAG 244 Query: 299 TETTSTTLRYALLLLL-KHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQR 357 ETTS L + LL EV ++ E ++ V V E+ R Sbjct: 245 VETTSHLLANSFYSLLYDDKEVYQELHENLDLV------------------PQAVEEMLR 286 Query: 358 YIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG 417 + L V D + +G +++ +++ D + F +P + ++ Sbjct: 287 FR-FNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNKK- 344 Query: 418 NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTT 470 + F G C+G LAR+E + LT L+ F + L+ Sbjct: 345 -------HLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAVPSFQLEEN 390 >5LIV-A nrPDB Length = 450 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 96/263 (36%), Gaps = 41/263 (15%) Query: 231 NKLLKNLAFMES--DILEKVKEHQESMDI------NNPRDFIDCFLIKMEKEKQNQQSEF 282 +L+ L M + E + + E++ + RD D L ++ + + + + Sbjct: 206 RAMLRGLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMD- 264 Query: 283 TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR 342 TIE L+ G ETTS + + LL HP+ A+V+++ Sbjct: 265 TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS-------------- 310 Query: 343 GHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFP 402 A + E R+ + V DV+ + + GT + + + +D +P Sbjct: 311 ----LLPAAIEEGMRWC-PSSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYP 365 Query: 403 NPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLI 462 +PE++D N F G CVG LARME + L +L F + Sbjct: 366 SPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVGLQALLARFPGLRAV 417 Query: 463 DPKDLDT-----TPVVNGFASVP 480 + V +G +P Sbjct: 418 PEERPSFMYGAKDSVAHGPDKLP 440 >2WM5-A nrPDB Length = 435 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 65/419 (15%), Positives = 134/419 (31%), Gaps = 77/419 (18%) Query: 75 VVLHGYEVVKEALIDLGEEFSGRGHFPLAERA-----NRGFGIVFSNGKRWKEIRRFSLM 129 L Y+ V A + FS + + ++ G IV + R + +R Sbjct: 77 WALTKYDDVFYA-SRHPDIFSSYPNITINDQTPELAEYFGSMIVL-DDPRHQRLRSIVSR 134 Query: 130 TLRNFGMGKRSIEDRVQEEARCLVEEL-RKTKASPCDPTFIL-GCAPCNVICSIIF---- 183 + + IE V++ A LV + D L G P +IC ++ Sbjct: 135 AFTPKVVAR--IEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKA 192 Query: 184 -QKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMES 242 +R + L + + +F + ++ ++ + Sbjct: 193 DHQRIFHWTNVILGFGDPD-------------LATDFDEFM--------QVSADIGAYAT 231 Query: 243 DILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETT 302 + E + N D + L++ E + + + + L+ AG ETT Sbjct: 232 ALAEDRR--------VNHHDDLTSSLVEAEVDGE----RLSSREIASFFILLVVAGNETT 279 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLI 362 + + +L L ++PE + + + V E+ R+ + Sbjct: 280 RNAITHGVLALSRYPEQRDRWWSDFDG-----------------LAPTAVEEIVRWASPV 322 Query: 363 PTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS 422 + +T D++ R + G + S D +F +P FD Sbjct: 323 -VYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR---------NP 372 Query: 423 NYFMPF-SAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480 N + F G C+G LAR E+ + + + + + ++G ++P Sbjct: 373 NPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLP 431 >6F88-A nrPDB Length = 400 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 96/263 (36%), Gaps = 41/263 (15%) Query: 231 NKLLKNLAFMES--DILEKVKEHQESMDI------NNPRDFIDCFLIKMEKEKQNQQSEF 282 +L+ L M + E + + E++ + RD D L ++ + + + + Sbjct: 156 RAMLRGLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMD- 214 Query: 283 TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDR 342 TIE L+ G ETTS + + LL HP+ A+V+++ Sbjct: 215 TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS-------------- 260 Query: 343 GHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFP 402 A + E R+ + V DV+ + + GT + + + +D +P Sbjct: 261 ----LLPAAIEEGMRWCPSN-FGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYP 315 Query: 403 NPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLI 462 +PE++D N F G CVG LARME + L +L F + Sbjct: 316 SPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVGLQALLARFPGLRAV 367 Query: 463 DPKDLDT-----TPVVNGFASVP 480 + V +G +P Sbjct: 368 PEERPSFMYGAKDSVAHGPDKLP 390 >4DO1-A nrPDB Length = 410 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 41/248 (16%), Positives = 86/248 (34%), Gaps = 28/248 (11%) Query: 233 LLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAA 292 + +E+ HQ ++ R + E T + + Sbjct: 185 AFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVR 244 Query: 293 DLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVV 352 LL AG +TT + A+ L + P +++ + Sbjct: 245 SLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDP------------------TLARNAF 286 Query: 353 HEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHF 412 E R+ + + T +V+ +I +G +L L S D + + +P+++D Sbjct: 287 EEAVRFESPVQ-TFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITR- 344 Query: 413 LDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472 K++ + F +G +CVG+ +AR+E + L+ + + + P Sbjct: 345 --------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGPVKRRFNNT 396 Query: 473 VNGFASVP 480 + G S+P Sbjct: 397 LRGLESLP 404 >1F4U-A nrPDB Length = 368 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 67/435 (15%), Positives = 143/435 (32%), Gaps = 80/435 (18%) Query: 50 VSKSLTNLSKI----Y-GPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAE 104 + + + K Y G ++ ++ VL+ + L E + + Sbjct: 1 MYDWFSEMRKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRNGKIRF 60 Query: 105 RANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPC 164 + ++ S+ E+R S + +++E ++E R L++ + + Sbjct: 61 DIPTRYTMLTSDPPLHDELRSMSADIFSPQKL--QTLETFIRETTRSLLDSIDPREDDIV 118 Query: 165 DPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIID 224 + P VI I+ +D++ K E +V+ + F Sbjct: 119 --KKLAVPLPIIVISKILG---LPIEDKE------KFKEWSDLVAFRLGKPGEIFELGKK 167 Query: 225 YFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTI 284 Y +++ VK+H S E + S + Sbjct: 168 YL----------------ELIGYVKDHLNS---------------GTEVVSRVVNSNLSD 196 Query: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344 + LL AG ETT+ + +++ + + +++EE Sbjct: 197 IEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREE------------------ 237 Query: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404 + E RY + ++ VK + I +G + + S D + F + Sbjct: 238 -NLYLKAIEEALRYSPPVMRTV-RKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDG 295 Query: 405 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDP 464 E F P N + F +G +C+G LAR+E + + + F ++D Sbjct: 296 EKFIPDR---------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEILDT 346 Query: 465 KDLDTTPVVNGFASV 479 + + V+NG+ + Sbjct: 347 EKVPNE-VLNGYKRL 360 >3RWL-A nrPDB Length = 426 Score = 151 bits (381), Expect = 7e-37, Method: Composition-based stats. Identities = 57/363 (15%), Positives = 111/363 (30%), Gaps = 60/363 (16%) Query: 118 KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177 R E R+ + + +E ++E ++ L D + Sbjct: 117 PRHDEQRKAVSPIVAPANLAA--LEGTIRERVSKTLDGLPV--GEEFDWVDRVSIEITTQ 172 Query: 178 ICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKL-LKN 236 + + +F F+ + + T W + P K L Sbjct: 173 MLATLFDFPFEERRK----------------LTRWSDVTTAAPGGGVVESWDQRKTELLE 216 Query: 237 LAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLG 296 A + + +P + + L + T E + L+ Sbjct: 217 CAAYFQVLWNER-------VNKDPGNDLISMLAHSPATRN-----MTPEEYLGNVLLLIV 264 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQ 356 G +TT ++ +L L K+P+ AK++ V + +V E+ Sbjct: 265 GGNDTTRNSMTGGVLALHKNPDQFAKLKANPALV------------------ETMVPEII 306 Query: 357 RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416 R+ + + D + I KG ++ S D++ PE F Sbjct: 307 RWQTPLAH-MRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR----- 360 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGF 476 + + F G CVG LA M+L + IL F+ ++ + + V G+ Sbjct: 361 ---PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERVRSNFVRGY 417 Query: 477 ASV 479 A + Sbjct: 418 AKM 420 >2NZA-A nrPDB Length = 413 Score = 150 bits (380), Expect = 9e-37, Method: Composition-based stats. Identities = 82/472 (17%), Positives = 142/472 (30%), Gaps = 83/472 (17%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYF--GLERMVVLH 78 ++ G+ PP P L +D + L L GP+ + G + Sbjct: 4 ETTTLTGQSPPPVRDWPA----LDLDGPEFDPVLAELM-REGPLTRVRLPHGEGWAWLAT 58 Query: 79 GYEVVKEALIDLG---EEFSGRGHFPLAERA-NRGFGIVFSNGKRWKEIRRFSLMTLRNF 134 Y+ VK D E + R LA R + F++ +RR F Sbjct: 59 RYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQPDHNRLRRAVAGA---F 115 Query: 135 GMGK-RSIEDRVQEEARCLVEELRKTKASPCDPT-FILGCAPCNVICSIIFQKRFDYKDQ 192 +G + + R QE LV+ + P D +L P V+ ++ Sbjct: 116 TVGATKRLRPRAQEILDGLVDGILAE-GPPADLVERVLEPFPIAVVSEVMG--------- 165 Query: 193 QFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQ 252 V + +++ I G + + I E V+ Sbjct: 166 ---------------VPAADRERVHSWTRQIISTSGGAEAAERAKRGLYGWITETVRAR- 209 Query: 253 ESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLL 312 + + L + ++ V A L G E + + L L Sbjct: 210 ----AGSEGGDVYSMLGAAVGRGEVGET-----EAVGLAGPLQIGG-EAVTHNVGQMLYL 259 Query: 313 LLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL-IPTSLPHAVT 371 LL E+ A+++E + E+ R+I L Sbjct: 260 LLTRRELMARMRERPGA------------------RGTALDELLRWISHRTSVGLARIAL 301 Query: 372 CDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAG 431 DV+ I G + S + D FP+P+ D N + + G Sbjct: 302 EDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDR---------DPNPHLAYGNG 352 Query: 432 KRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD---LDTTPVVNGFASVP 480 C G LARM+ L + +L+ L P + ++ G ++P Sbjct: 353 HHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRRKTMIRGPRTLP 404 >1UE8-A nrPDB Length = 367 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 59/330 (17%), Positives = 122/330 (36%), Gaps = 46/330 (13%) Query: 152 LVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTP 211 L +ELR A +P+ + V ++ D++F + +V + Sbjct: 75 LHDELRNLTADAFNPSNLPVDFVREVTVKLL-----SELDEEFDVIESFAIPLPILVISK 129 Query: 212 WIQICNNFPTIIDYFPGTHNKLLK--NLAFMESDILEKVKEHQESMDINNPRDFIDCFLI 269 + I + + D+ +L + + + LE + ++ +D ++ +D Sbjct: 130 MLGINPDVKKVKDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKGKEIVD---- 185 Query: 270 KMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 + S + L+ AG ETT+ + A IE Sbjct: 186 ---LTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNA-----------------IED 225 Query: 330 VVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILT 389 N ++++G + V E R+ + ++ VK R+ +I +G + Sbjct: 226 FTLYNSWDYVREKGALK----AVEEALRFSPPVMRTI-RVTKEKVKIRDQVIDEGELVRV 280 Query: 390 SLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFL 449 + S D + F +P+ F P N + F +G +C+G LAR+E + L Sbjct: 281 WIASANRDEEVFKDPDSFIPDR---------TPNPHLSFGSGIHLCLGAPLARLEARIAL 331 Query: 450 TFILQNFNLKSLIDPKDLDTTPVVNGFASV 479 + F +K ++ + +D V+NG+ + Sbjct: 332 EEFAKKFRVKEIVKKEKIDNE-VLNGYRKL 360 >1Q5D-A nrPDB Length = 419 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 75/441 (17%), Positives = 149/441 (33%), Gaps = 64/441 (14%) Query: 47 IKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERA 106 +D ++ L + P+F G R VL Y V D S AE + Sbjct: 25 AEDPFPAIERLREA-TPIFYWDEG--RSWVLTRYHDVSAVFRDERFAVSREEWESSAEYS 81 Query: 107 N--------RGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRK 158 + + +G+ + +R+ + + +Q L++ R Sbjct: 82 SAIPELSDMKKYGLFGLPPEDHARVRKLVNPSFT--SRAIDLLRAEIQRTVDQLLDA-RS 138 Query: 159 TKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNN 218 + P I +++ K D++F + + P ++ Sbjct: 139 GQEEFDVVRDYAEGIPMRAISALL--KVPAECDEKFRRFGSATARALGVGLVP--RVDEE 194 Query: 219 FPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQ 278 T++ + + LA + + E+ + E+ + L++ E + Sbjct: 195 TKTLVA-------SVTEGLALLHGVLDERRRNPLEN--------DVLTMLLQAEADG--- 236 Query: 279 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 338 S + + LV ++ AGT+TT + +A+L LL+ PE V+ E Sbjct: 237 -SRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPG---------- 285 Query: 339 MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 + EV R+ +++ D+++ I KG + + S L D Sbjct: 286 --------LMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDG 337 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 F P++FD R ++ + + G +C G LAR+E + + I + F Sbjct: 338 TVFSRPDVFDVRR---------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPE 388 Query: 459 KSLIDPKDLDTTPVVNGFASV 479 L + P S+ Sbjct: 389 MKLKETPVFGYHPAFRNIESL 409 >2X9P-A nrPDB Length = 404 Score = 149 bits (376), Expect = 3e-36, Method: Composition-based stats. Identities = 74/437 (16%), Positives = 132/437 (30%), Gaps = 78/437 (17%) Query: 54 LTNLSKIYGPVFTLYF-GLERMVVLHGYEVVKEALIDL--GEEFSGRGHFP-LAERANRG 109 L + GP+ + + ++ + +K+ L D G Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLD 90 Query: 110 FGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIE--DRVQEEARCLVEELRKTKASPCDPT 167 I ++ + + + L +R +E +V+E A L++ + P D Sbjct: 91 LLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAF-IAQGPPGDLH 149 Query: 168 FILGC-APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYF 226 L V+C +I Q+ L L ++ Sbjct: 150 GELTVPFALTVLCEVI-----GVPPQRRAELTTLLAGIAKL------------------- 185 Query: 227 PGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIEN 286 ++ + + V+ + P I L E T + Sbjct: 186 -DDREGAVRAQDDLFGYVAGLVEHKRA-----EPGPDIISRL---------NDGELTEDR 230 Query: 287 LVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMP 346 + A LL AG ++ ++ + ++LL HP+ A + + Sbjct: 231 VAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD------------------ 272 Query: 347 YTDAVVHEVQRYIDLIPTSLP-HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPE 405 V EV R + LP + D++F I G +L L D + F PE Sbjct: 273 VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPE 332 Query: 406 MFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPK 465 FD + N + F G C+G LAR+EL T + P Sbjct: 333 EFD---------AARTPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPV 383 Query: 466 D---LDTTPVVNGFASV 479 + L + GFA + Sbjct: 384 EQLRLKEGQLSGGFAEL 400 >5EX8-A nrPDB Length = 424 Score = 149 bits (376), Expect = 3e-36, Method: Composition-based stats. Identities = 65/398 (16%), Positives = 122/398 (30%), Gaps = 71/398 (17%) Query: 71 LERMVVLHGYEVVKEALIDLGEEFSGRGHFP-LAERANRGFGIVFSNGKRWKEIRRFSLM 129 + G + V++ L ++FS R + A + + +RR + Sbjct: 78 GRTAWLATGIDEVRQVL--GSDKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVP 135 Query: 130 TLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN-VICSIIFQKRFD 188 + M + RV++ + ++ + ++ P D G A C + R D Sbjct: 136 AFSHRRM--QKFRPRVEQIVQDSLDTI-ESLGGPVDFVPHFGWAIATPATCDFLGIPRDD 192 Query: 189 YKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV 248 D + L + ++ K + + + Sbjct: 193 QADLARILLASRT-----------------------------DRSDKRRTAAGNKFMTYM 223 Query: 249 KEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRY 308 K+H + D + T L AA ++GA + + L Sbjct: 224 KQHVAQSRRGSGDDLFGIV-------GRENGDAITDAELTGVAAFVMGAAADQVARLLAA 276 Query: 309 ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPH 368 L+++ P A ++E+ E V P D E RY+ + P Sbjct: 277 GAWLMVEQPAQFALLREKPETV------PEWLD------------ETMRYLTTDEKTHPR 318 Query: 369 AVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPF 428 T DV+ N L+ G T+ SL + + FD E + F Sbjct: 319 VATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITREKAE---------HLAF 368 Query: 429 SAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466 G C+G +A + + + + F L DP+ Sbjct: 369 GHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLADPQR 406 >5FYF-A nrPDB Length = 470 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 67/481 (13%), Positives = 157/481 (32%), Gaps = 70/481 (14%) Query: 16 LLSIWRQSSGRGKLPPG--PTPLPVIGNI---------LQIDIKDVSKSLTNLSKIYGPV 64 L+S R++ G + P TP+P + + + + ++ + PV Sbjct: 35 LMSAKRKTFGPRRPMPEFVETPIPDVNTLALEDIDVSNPFLYRQGQWRAYFKRLRDEAPV 94 Query: 65 -FTLYFGLERMVVLHGYEVVKEALIDLGEE-FSGRGHFPLAERANRGFGI---VFSNGKR 119 + + +E + +D + FS L + G + + + + Sbjct: 95 HYQKNSPFGPFWSVTRFEDI--LFVDKSHDLFSAEPQIILGDPP-EGLSVEMFIAMDPPK 151 Query: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVIC 179 R + + + +E ++ +++ L K P + + + Sbjct: 152 HDVQRSSVQGVVAPKNL--KEMEGLIRSRTGDVLDSLPTDK--PFNWVPAVSKELTGRML 207 Query: 180 SIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAF 239 + + D+ ++ L+E + S + + N + + A Sbjct: 208 ATLL----DFPYEERHKLVEWSDRMAGAASATGGEFAD------------ENAMFDDAAD 251 Query: 240 MESDILEKVKEHQESMDINN-PRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAG 298 M ++ + P + L ++ K + L+ G Sbjct: 252 MARSFSRLWRDKEARRAAGEEPGFDLISLLQSNKETKDLINRPM---EFIGNLTLLIVGG 308 Query: 299 TETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRY 358 +TT ++ L+ + + P K++ + E + +V E+ R+ Sbjct: 309 NDTTRNSMSGGLVAMNEFPREFEKLKAKPELI------------------PNMVSEIIRW 350 Query: 359 IDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN 418 + + DV+ I KG ++ S D ++F NP+ F Sbjct: 351 QTPLAY-MRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR------- 402 Query: 419 FKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFAS 478 K + M F G C+G LA ++L + IL+ F+ +++ + + V G++ Sbjct: 403 -KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEPERVQSNFVRGYSR 461 Query: 479 V 479 + Sbjct: 462 L 462 >2RFC-A nrPDB Length = 343 Score = 147 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 69/413 (16%), Positives = 131/413 (31%), Gaps = 91/413 (22%) Query: 74 MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVF--SNGKRWKEIRRFSLMTL 131 ++ Y VK L++ + FS R + GI F + KE R S Sbjct: 12 AWHVYKYSDVKHVLMN-DKIFSSNP----GNRYSNAGGISFITMDNPEHKEFRDISAPYF 66 Query: 132 RNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG----CAPCNVICSIIFQKRF 187 + ++ + + +EE D I+ P N+I I+ Sbjct: 67 ---------LPSKINDY-KDFIEETSNDLIKNIDNKDIISEYAVRLPVNIISKIL----- 111 Query: 188 DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK 247 I P ++ +++ NK +N ++ + ++ + Sbjct: 112 ----------------GIPDSDMPLFKLWSDYII--------GNKRDENFNYVNNRMVSR 147 Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 + E +S +I + + + T++ + L+ G ETT+ + Sbjct: 148 LLEIFKSDSHG---------IINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIG 198 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP 367 + ++ ++P++ + V E RY I Sbjct: 199 NMIRVIDENPDIID---------------------DALKNRSGFVEETLRYYSPIQFLPH 237 Query: 368 HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMP 427 D N I KG ++ L S D F P++F + Sbjct: 238 RFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGRR----------EMHLA 287 Query: 428 FSAGKRICVGEGLARMELFLFLTFILQNF-NLKSLIDPKDLDTTPVVNGFASV 479 F G +C+G LAR+E + L IL +F +K L +V G+ + Sbjct: 288 FGIGIHMCLGAPLARLEASIALNDILNHFKRIKIDYKKSRLLDNKMVLGYDKL 340 >6CVC-A nrPDB Length = 433 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 63/414 (15%), Positives = 138/414 (33%), Gaps = 67/414 (16%) Query: 75 VVLHGYEVVKEALIDLGEEFSGRGHFPLAERA-----NRGFGIVFSNGKRWKEIRRFSLM 129 L ++ + E F + + ++ G IV + R + +R Sbjct: 74 WALTKHDDIH-FASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVL-DDPRHQRLRSIVSR 131 Query: 130 TLRNFGMGKRSIEDRVQEEARCLVEELRKTKASP-CDPTFIL-GCAPCNVICSIIFQKRF 187 + + IE V+E A LV + + D L G P +IC ++ Sbjct: 132 AFTPKVVAR--IEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEE 189 Query: 188 DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK 247 D++ + + I+ + +F + ++ + + + + Sbjct: 190 DHE--------QIFHWTNVILGFGDPDLTTDFDEFL--------QVSMAIGGYATALADD 233 Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 + +N+ D L++ E + + + + + L+ AG ETT + Sbjct: 234 RR-------VNHHGDLTTS-LVEAEVDGE----RLSSSEIAMFFILLVVAGNETTRNAIS 281 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP 367 + +L L ++P+ AK + + + V E+ R+ + + Sbjct: 282 HGMLALSRYPDERAKWWSDFDGLAAT-----------------AVEEIVRWASPV-VYMR 323 Query: 368 HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMP 427 ++ DV R + G + S D ++F +P FD + N + Sbjct: 324 RTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFD---------VTRNPNPQVG 374 Query: 428 F-SAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480 F G C+G LAR E+ + + + + + ++G +P Sbjct: 375 FGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLP 428 >6HQW-A nrPDB Length = 445 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 55/373 (14%), Positives = 112/373 (30%), Gaps = 44/373 (11%) Query: 111 GIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFIL 170 GI + + ++ + L F R + T A + + Sbjct: 106 GITIGDPPEDVDPQKLAERQLPMFIAMDRP-----DHTGQRRTVAPAFTPAKMVEMEAEI 160 Query: 171 GCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTH 230 +V+ S+ + +RFD+ D+ +E + I+ D+ Sbjct: 161 RRRTASVLDSLPWGERFDWVDKVS---IELTTGMLAILFGFPWADRRLLTFWSDWAGDVE 217 Query: 231 NKLLKNLAFME----SDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIEN 286 L + LA ++ + + P + +I E + + + Sbjct: 218 LTLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEA-----MNHMSPQE 272 Query: 287 LVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMP 346 + L+ G +TT T+ + L K P+ ++ + + Sbjct: 273 FMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDASLI---------------- 316 Query: 347 YTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEM 406 V E RY+ + + T D + I G ++ S D F NP+ Sbjct: 317 --PNAVQECIRYVTPLAH-MRRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDK 373 Query: 407 FDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKD 466 + + F G CVG LA ++L + L + + + + Sbjct: 374 LMVDR--------PNARRHLSFGHGIHRCVGARLAELQLRILLEEMHERRMRVRVAGEVE 425 Query: 467 LDTTPVVNGFASV 479 V+GF + Sbjct: 426 RVRANFVHGFRKL 438 >5DQN-A nrPDB Length = 426 Score = 141 bits (355), Expect = 7e-34, Method: Composition-based stats. Identities = 41/223 (18%), Positives = 77/223 (34%), Gaps = 35/223 (15%) Query: 256 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315 NP + I LI+ + + + + + + L AG ETT ++ + ++ + Sbjct: 214 RAVNPTEDIVTKLIEADIDGE----KLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQ 269 Query: 316 HPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 375 +P+ ++E + E+ R+ + + DV+ Sbjct: 270 NPDQWELYKKERP--------------------ETAADEIVRWATPVS-AFQRTALEDVE 308 Query: 376 FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSA-GKRI 434 I KG ++ S S D + F +P F+ + N + F G Sbjct: 309 LGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNI---------LRSPNPHVGFGGTGAHY 359 Query: 435 CVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFA 477 C+G LARM + L I N I + + +NG Sbjct: 360 CIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLNGIK 402 >4PWV-A nrPDB Length = 446 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 65/417 (15%), Positives = 130/417 (31%), Gaps = 71/417 (17%) Query: 75 VVLHGYEVVKEALIDLGEEFSGRGHFPLAERA----NRGFGIVFSNGKRWKEIRRFSLMT 130 V+ Y V D + S +G+ + A G + ++G + +R L + Sbjct: 77 WVVSRYADVMALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKS 136 Query: 131 LRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCA---PCNVICSIIFQKRF 187 ++++ V + R L A + F A P N I ++ Sbjct: 137 FSP-----QALKPIVDQI-RVNTTRLVVDAARRGECDFAADVAEQIPLNTISDLLG---V 187 Query: 188 DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK 247 D++FL + K + I+ YF S+++ + Sbjct: 188 PAADREFLLKLNKSALSSEDADQSATDAWLARNEILLYF---------------SELVAE 232 Query: 248 VKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLR 307 + P + + L + + T E +V+ L+ G ET+ ++ Sbjct: 233 RRAK--------PTEDVISVLANSMVDGKP----LTEEVIVLNCYSLILGGDETSRLSMI 280 Query: 308 YALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP 367 ++ ++P+ +++ ++ EV R+ Sbjct: 281 DSVQTFTQYPDQWELLRDGKVT------------------LESATEEVLRWATPAMHFGR 322 Query: 368 HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMP 427 AVT D++ +I G + S D + F +P FD N + Sbjct: 323 RAVT-DMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR---------SPNKHIT 372 Query: 428 FSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484 F G C+G L R E+ L + + + + G + +P Q Sbjct: 373 FGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEPQRIHSNFLTGLSRLPVRIQ 429 >6GII-A nrPDB Length = 479 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 65/425 (15%), Positives = 131/425 (30%), Gaps = 69/425 (16%) Query: 51 SKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERAN--- 107 ++ P+F Y V+ Y+ +K+ D FS + + Sbjct: 80 PAQFVRWAREQVPIF--YAPKLNYWVVTRYDTIKQIFRDP-VTFSPSNVLQSFAQPSAEV 136 Query: 108 ----RGFGIVFS-----NGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRK 158 +G F+ + RR + +E E +R+ Sbjct: 137 RQVLERYGYAFNRTLVNEDEPMHLERR------------RVLMEPFASEHLAEHEPMVRE 184 Query: 159 TKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNN 218 + + +++ +I++ F FL + + E +R + I + Sbjct: 185 LVRRAVN--RFIDTGRADLVDQMIWEVPFTVALH-FLGVDDDDREKMRRFA-----IAHT 236 Query: 219 FPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQ 278 P + + + E +++ + + D + ++++ Sbjct: 237 VNAFGRPSPEEQLAVAETVGQFWQFCGEVLEKMRRTADGPGW-------MRYSIRQQKLY 289 Query: 279 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 338 T L ++ A ETT AL LL+H V ++ + + Sbjct: 290 PDVVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREICADPSLI-------- 341 Query: 339 MQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDN 398 A E RY + T +V+ +P G IL + S HD+ Sbjct: 342 ----------PAAAEECLRYNGPV-AGWRRRTTREVEVEGVRLPVGANILMVVASANHDS 390 Query: 399 KEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458 F +PE FD ++ + F G C+G L RME+ + + + + Sbjct: 391 AHFDDPEFFDIGR--------SNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPH 442 Query: 459 KSLID 463 L + Sbjct: 443 MRLAE 447 >5HIW-A nrPDB Length = 398 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 87/447 (19%), Positives = 148/447 (33%), Gaps = 74/447 (16%) Query: 41 NILQIDIKDVSKSLTNLSK--IYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRG 98 N+ KD S +L+ V+ GL VVL G +VV A++ E FS R Sbjct: 6 NLFSFTSKDPSAFGIHLAAAAREHSVY-FDEGLGVPVVLRGADVV--AVLRDSETFSTR- 61 Query: 99 HFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEEL-R 157 + +V G+ +RR L + R E V AR +VE L R Sbjct: 62 ---TYDTGIMKGALVTLGGEAHTRMRRLFNAVLSP-RVISRYEEATVTPVARRVVERLVR 117 Query: 158 KTKASPCDPTFILGCAPCNVICSIIFQ---KRFDYKDQQFLNLMEKLNENIRIVSTPWIQ 214 K +A D + + S +F +R D ++ Sbjct: 118 KERAELFDD---FAISMPMGVTSALFGLPEERIAENDALIRKMIR--------------- 159 Query: 215 ICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKE 274 ++ P + A ME+ + E + ++ +P D + + + Sbjct: 160 -----SVVMPQDPVVVAEGRSAHAAMEAQLREIAER-----EVAHPSDTLLGEIARAIVA 209 Query: 275 KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRN 334 + +E L+ ETTS L L+ LL HP+ +++++ Sbjct: 210 EGLGG----VEACEGVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLRQQPS------ 259 Query: 335 RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSV 394 + E R+ + V + + GT + SL + Sbjct: 260 ------------LLPQAIEESTRWCSSA-AGIVRFVEREATIGGETLAAGTILYLSLIAR 306 Query: 395 LHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQ 454 +D + +P PE FD + + F G CVG LARME + ++ +L+ Sbjct: 307 HYDEEIYPRPETFDIHR---------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLE 357 Query: 455 NFNLKSLIDPKDLDTTPVVNGFASVPP 481 F + G A+ P Sbjct: 358 RFPALRADPTVQPTFSTAPRGAAAFGP 384 >5HDI-A nrPDB Length = 404 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 70/432 (16%), Positives = 121/432 (28%), Gaps = 86/432 (19%) Query: 68 YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFG--------------IV 113 + G++ V EA I E+FS G + Sbjct: 34 RIANSDFYAVCGWDAVNEA-IGRPEDFSS-NLTATMTYTAEGTAKPFEMDPLGGPTHVLA 91 Query: 114 FSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCL-VEELRKTKASPCDPTFILGC 172 ++ R+ L L + R +E + A L V+ ++ + Sbjct: 92 TADDPAHAVHRKLVLRHLAAKRI--RVMEQFTVQAADRLWVDGMQD--GCIEWMGAMANR 147 Query: 173 APCNVICSIIFQ-----KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP 227 P V+ +I + L+E L EN ++V+ Sbjct: 148 LPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGV--------------- 192 Query: 228 GTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENL 287 L + I E+ +PRD + L E Sbjct: 193 --------ALMELSGYIFEQFDR-----AAADPRDNLLGELATACASG-----ELDTLTA 234 Query: 288 VITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPY 347 + L AG E+T+ L A+ +L P++ +V+ E Sbjct: 235 QVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPE------------------L 276 Query: 348 TDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMF 407 A + E RY H +P + +L + D +F P F Sbjct: 277 LGAFIEETLRYEPPFRGHYRHVRNA-TTLDGTELPADSHLLLLWGAANRDPAQFEAPGEF 335 Query: 408 DPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL 467 +G + F G CVG LAR+E + L +L ++ D Sbjct: 336 RLDRAGGKG--------HISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGW 387 Query: 468 DTTPVVNGFASV 479 + +V + Sbjct: 388 LPSILVRRIERL 399 >5H1Z-A nrPDB Length = 407 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 49/364 (13%), Positives = 111/364 (30%), Gaps = 60/364 (16%) Query: 118 KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177 + RR M + D ++ +++ L +P D + Sbjct: 97 PKHTGQRRTVAPAFTPSEM--VRMSDNIRMRTAEVLDSLEWN--TPFDWVDTVSVELTTQ 152 Query: 178 ICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNL 237 + +I+F F +++++ L +I +V +++ + + Sbjct: 153 MLAILFD--FPWEERRKLTFWSDWAGDIELVKNEELRL-------------ERLRHMYEC 197 Query: 238 AFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGA 297 ++ + P + +I + +E + L+ Sbjct: 198 GGYFQNLWN-------AKIGKPPTPDLISMMIHS-----DAMAEMDQMEFLGNLILLIVG 245 Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQR 357 G +TT T+ L P+ AK++ + + V E+ R Sbjct: 246 GNDTTRNTMSAVAYGLDLFPDQRAKLEADPSMI------------------PNTVQEIIR 287 Query: 358 YIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG 417 + + + T D + I G + S D F N + Sbjct: 288 WQTPLAH-MRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDR------ 340 Query: 418 NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFIL-QNFNLKSLIDPKDLDTTPVVNGF 476 + + F G CVG LA +++ + L + + + L +P+ + V+G+ Sbjct: 341 --PNARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEPERV-AACFVHGY 397 Query: 477 ASVP 480 +P Sbjct: 398 RKLP 401 >3IVY-A nrPDB Length = 433 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 39/223 (17%), Positives = 76/223 (34%), Gaps = 35/223 (15%) Query: 256 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315 NP D I LI+ + + + + + + L AG ETT ++ ++ + Sbjct: 231 KAKNPADDIVTQLIQADIDGE----KLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAE 286 Query: 316 HPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 375 HP+ + +++ + E+ R+ + T+ D + Sbjct: 287 HPDQWE-LYKKVRP-------------------ETAADEIVRWATPV-TAFQRTALRDYE 325 Query: 376 FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSA-GKRI 434 I KG ++ S D + F +P F+ + N + F G Sbjct: 326 LSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNI---------LRNPNPHVGFGGTGAHY 376 Query: 435 CVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFA 477 C+G LARM + L + + I + + +NG Sbjct: 377 CIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIK 419 >2UUQ-A nrPDB Length = 414 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 53/356 (14%), Positives = 107/356 (30%), Gaps = 62/356 (17%) Query: 112 IVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG 171 +V + E R+ + ++E V++ +E+LR T + Sbjct: 96 MVMQDPPVHTEFRKLVSRGFTPRQV--ETVEPTVRKFVVERLEKLRANGGGDI-VTELFK 152 Query: 172 CAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHN 231 P V+ + + E+ W Q + G Sbjct: 153 PLPSMVVA----------------HYLGVPEEDW-TQFDGWTQAIVAANAVD----GATT 191 Query: 232 KLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKE-KQNQQSEFTIENLVIT 290 L + M + ++ + P D L+ + + ++ Sbjct: 192 GALDAVGSMMAYFTGLIERRR-----TEPADDAISHLVAAGVGADGDTAGTLS---ILAF 243 Query: 291 AADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDA 350 ++ G +T + L ++ LL + P+ + ++ E + Sbjct: 244 TFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPD------------------ 285 Query: 351 VVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF-PNPEMFDP 409 V E+ R + L T DV + IP G +L S D +++ P+ D Sbjct: 286 AVEELLRLTSPVQ-GLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDV 344 Query: 410 RHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPK 465 + FS G C+G ARM+ + LT +L + + + Sbjct: 345 TRC---------PRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESR 391 >6DCD-A nrPDB Length = 424 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 38/216 (17%), Positives = 66/216 (30%), Gaps = 31/216 (14%) Query: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300 + +K + E D + + + ++V +A L AG E Sbjct: 200 LQWLDDKFSAYIEDRRRQPRNDVLTALATATYPDGSTP----EVIDVVRSATFLFAAGQE 255 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360 TT+ L A+ +L P++ +++E + + E R Sbjct: 256 TTAKLLTAAMRVLGDRPDIQRRLRENRSLI------------------PNFIEESLRMDS 297 Query: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420 + S I GT ++ + D + F +P F Sbjct: 298 PV-KSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR--------P 348 Query: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456 M F+ G C G LAR+E + L IL Sbjct: 349 NVREHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >6G5O-A nrPDB Length = 399 Score = 131 bits (329), Expect = 8e-31, Method: Composition-based stats. Identities = 78/445 (17%), Positives = 137/445 (30%), Gaps = 81/445 (18%) Query: 55 TNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID----LGEEFSGRGHFPLAERANRGF 110 SK YG + + + +L ++ V+++ + GR P Sbjct: 13 ARESKGYGE---MNDQDDPVTMLLRHKDVRKSAHNYKTFQSGAVPGRIVIPSEVDIRDTR 69 Query: 111 GIVFS-NGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 I F + R KR ++ QE+ + E+ + Sbjct: 70 QIPFEVDPPVHGVYRAIVE------PWFKRPLQAEYQEKLTAQISEIVEET--------- 114 Query: 170 LGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGT 229 L V+ F R + L ++TP+ + F Sbjct: 115 LLKGSVEVVTD--FALRLQSRALTLL------------LNTPFSESETWISWGTHVFRSE 160 Query: 230 HNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVI 289 L + A + +++ Q NP D + L+ E E + + T E + Sbjct: 161 GEALDGDKANILYHYIDE----QIDRASENPGDDMYSVLLNSEFEGR----KLTKEEVKG 212 Query: 290 TAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTD 349 G +T + ++ L +HPE ++++E E T Sbjct: 213 VMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPE------------------ITG 254 Query: 350 AVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDP 409 V E+ RY + T + VT D + + + I S D F NP Sbjct: 255 RAVEEMIRYFSPL-TQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVL 313 Query: 410 RHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID----PK 465 K N + F C+G AR L + L + Q ++D + Sbjct: 314 DR---------KVNPHVGFGFSHHNCLGATHARQILKILLQTLAQKVASFEILDYKENIE 364 Query: 466 DLDTTPVVNGFASVPPFYQLCFIPV 490 DLD GF ++ Q+ F P+ Sbjct: 365 DLDHFQRKVGFHNI----QIKFNPL 385 >1WIY-A nrPDB Length = 389 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 82/432 (18%), Positives = 137/432 (31%), Gaps = 73/432 (16%) Query: 36 LPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFS 95 P + ++ +D L + + +F L + ++ E V+ AL+ G + Sbjct: 10 WPYLKDL----QQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEGALLAEGTTKA 64 Query: 96 GRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEE 155 + L+ G G++ GK WKE R+ + R + ++EEA E Sbjct: 65 TFQYRALSRLT--GRGLLTDWGKSWKEARKA--LKDPFLPKSVRGYREAMEEEAWAFFGE 120 Query: 156 LRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQI 215 R D + ++ +F K Sbjct: 121 WR---GEERDLDHEMLALSLRLLGRALFGK------------------------------ 147 Query: 216 CNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEK 275 P LK L + + + + + +D + Sbjct: 148 --------PLSPSLAEHALKALDRIMAQTRSPLALLDLAAEARFRKDRGALYREAEALIV 199 Query: 276 QNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNR 335 S E + A LL AG ET ++ L ++ LLL P+ +V E E + Sbjct: 200 HPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAAF- 258 Query: 336 SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 395 E R L + + +P+GTT++ S Sbjct: 259 -----------------QEALRLYPPA-WILTRRLERPLLLGEDRLPQGTTLVLSPYVTQ 300 Query: 396 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN 455 FP E F P FL E G S + PF G+R+C+G A +E + L + Sbjct: 301 RL--YFPEGEAFQPERFLAERGT--PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRR 356 Query: 456 FNLKSLIDPKDL 467 F L L P+ L Sbjct: 357 FRLDPLPFPRVL 368 >3WEC-A nrPDB Length = 419 Score = 128 bits (322), Expect = 5e-30, Method: Composition-based stats. Identities = 65/449 (14%), Positives = 126/449 (28%), Gaps = 86/449 (19%) Query: 49 DVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDL--GEEFSGRGHFPLAE-- 104 D L P+ G ++ Y + L G++F+ F Sbjct: 25 DPYPVYARLRTEL-PIHRSALG---AWIVADYTSCDKVLRSRLFGKDFANSTFFDHLTSM 80 Query: 105 -----RANRGFGI-------VFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCL 152 G GI + ++ +R S++D V A Sbjct: 81 MGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFTRST--TTSMDDIVLSAASSA 138 Query: 153 VEELRKTKASPCDPTFILGCAPCNVICSIIFQKR--FDYKDQQFLNLMEKLNENIRIVST 210 V L + + + I I + R F +++ + V+ Sbjct: 139 VRHLEHCTDAVSEVAEPFPVEVLSSILGIPDKDRGRFSEWSNLVAGVLDINFAIPKEVAD 198 Query: 211 PWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIK 270 + IDYF + N P L++ Sbjct: 199 ---RRSAAIEESIDYF------------------------RTLATSGNAPE-----GLVR 226 Query: 271 MEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERV 330 E + + +++ + T + AG ETTS T+ L+ +H + +V+ + Sbjct: 227 RLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVRANPQ-- 284 Query: 331 VGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTS 390 + + V EV R+ + D + I KG ++ Sbjct: 285 ----------------FIENAVAEVLRFEPPAHEA-GRIALEDCEVSGANITKGDAVMVL 327 Query: 391 LTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT 450 L S + + F + + + G C+G LA L FL Sbjct: 328 LASGNR--EAVERGDTF---------SVTRPDVSSLSYGRGIHHCLGSALANSMLQHFLR 376 Query: 451 FILQNFNLKSLIDPKDLDTTPVVNGFASV 479 + Q + + +P + + G ++ Sbjct: 377 ELSQRYRSIEVAEPINYKPGMGLRGPETL 405 >6HQD-A nrPDB Length = 420 Score = 127 bits (320), Expect = 9e-30, Method: Composition-based stats. Identities = 47/309 (15%), Positives = 104/309 (33%), Gaps = 33/309 (10%) Query: 173 APCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHN- 231 V+ + + F++ D+ + L + + + + II PG Sbjct: 139 RTKRVLSELPIGEEFNWVDRVSIELTTMMLATLLDFPFDDRRKLTRWSDIITTRPGYGLV 198 Query: 232 KLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITA 291 + + L + P+ + L + + T + + T Sbjct: 199 DSWEQRESELMECLAYFQRLYAERQAMPPKPDLISMLAHS-----PEMQDLTPTDFLGTL 253 Query: 292 ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAV 351 A L+ G +TT +++ + + +P+ KV+ +V Sbjct: 254 ALLIVGGNDTTRSSMSGSAMACHLYPQEFDKVRNNRA------------------LLASV 295 Query: 352 VHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRH 411 + EV R+ I + DV+FR I KG ++ S D++ P F Sbjct: 296 IPEVVRWQTPIAH-MRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADR 354 Query: 412 FLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTP 471 ++ + + F G C+G LA ++L + + + ++ + + Sbjct: 355 --------PRARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSN 406 Query: 472 VVNGFASVP 480 +V+G+ +P Sbjct: 407 LVHGYIDIP 415 >2IJ7-A nrPDB Length = 396 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 43/212 (20%), Positives = 70/212 (33%), Gaps = 27/212 (12%) Query: 274 EKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGR 333 K S + E GAG +T + L AL+ L++ P++ + E+ E + Sbjct: 210 RKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELI--- 266 Query: 334 NRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTS 393 A V E+ R LP T D++ + L+ KG +L L Sbjct: 267 ---------------PAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEG 311 Query: 394 VLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFIL 453 D + FPNP + + F G+ C G L R + + +L Sbjct: 312 ANFDPEHFPNPGSIELDR--------PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALL 363 Query: 454 QNFNLKSLIDPKDLDTTPVVNGFASVPPFYQL 485 + L P D +P + Sbjct: 364 KKMPGVDLAVPID-QLVWRTRFQRRIPERLPV 394 >6BLD-A nrPDB Length = 419 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 68/409 (16%), Positives = 119/409 (29%), Gaps = 62/409 (15%) Query: 73 RMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLR 132 +V + V L G F AE + + R ++R+ Sbjct: 69 DIVAVSRTNEV--FLSGNGVLFENVP----AELLEASQSFLAMDPPRHTKLRKLVSAAFT 122 Query: 133 NFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFQKRFDYKD 191 + R IED ++ A+ +V+ELR D P + ++ D + Sbjct: 123 PRQV--RRIEDSIKINAKGIVDELRMA-GGGVDFVEHCAKELPIRTLSDMVGIPEADRE- 178 Query: 192 QQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEH 251 + +VS + N + F L +V Sbjct: 179 -------RVAHAADALVSWADPRYLNGREPLAVLFEN-------------QMYLHQVAAS 218 Query: 252 QESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALL 311 + + P D + L+ E + ++ L AG +TT T+ + L Sbjct: 219 LAAERRDRPGDDLFSALVNAEVDG----DRLADADVAAFFVLLAVAGNDTTRQTISHGLK 274 Query: 312 LLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVT 371 L P A + + + +G V E+ R+ + + Sbjct: 275 ALTDFPSQKAWLLADFDTRIGT-----------------AVEELVRWATPVM-TFRRTAA 316 Query: 372 CDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAG 431 D + LI G ++ S D F +PE D + F Sbjct: 317 ADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVH------ 370 Query: 432 KRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480 C+G LAR +L +L DP + V+ S+P Sbjct: 371 --FCLGAHLARAQLRAIFGELLVQLPDIQAGDPVYVPGN-FVHAIRSMP 416 >6G71-A nrPDB Length = 405 Score = 124 bits (312), Expect = 6e-29, Method: Composition-based stats. Identities = 71/435 (16%), Positives = 132/435 (30%), Gaps = 64/435 (14%) Query: 48 KDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERAN 107 ++ L PV + ++ Y V A +D FS L RA Sbjct: 21 QNPFPIFERLRS-ESPVAWVPEAGRY--LITSYSGVLAADVDQ-TTFSANEKKSLMLRA- 75 Query: 108 RGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT 167 G ++ + + RR +L+ G K+ + + E A ++ S D Sbjct: 76 MGHSMLRKDDPDHQVERRAWQPSLKP-GTVKKVWKQKFAENADRYLDAY-IDAGSGSDFM 133 Query: 168 FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFP 227 F F ++ L + W Q + P Sbjct: 134 Q-------------GFAAPFVAEN---LRALIGFENASEADLQRWSQTLIDGAGNYPDDP 177 Query: 228 GTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENL 287 K ++ +++ + E ++ H P D + +L+ ++ + +E++ Sbjct: 178 DVWAKAKQSSDEIDAALEEMIQWH-----SGRPGDSLLSYLL------RSADYQMPLESI 226 Query: 288 VITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPY 347 +G G L + L LL + V + Sbjct: 227 RSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELVLRDP------------------KL 268 Query: 348 TDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMF 407 AV E R++ I +P D + Y IP+G + + S D + +P+ F Sbjct: 269 WGAVFEESIRWVAPI-GMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRF 327 Query: 408 DPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME-LFLFLTFILQNFNLKSLIDPKD 466 D S + F G +C+G AR + + L + L ++ Sbjct: 328 DIER---------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKGLRLDPNQE 378 Query: 467 LDTTPVV-NGFASVP 480 V G S+P Sbjct: 379 ATHGGWVFRGPLSLP 393 >2IAG-A nrPDB Length = 482 Score = 124 bits (312), Expect = 7e-29, Method: Composition-based stats. Identities = 92/499 (18%), Positives = 169/499 (33%), Gaps = 64/499 (12%) Query: 22 QSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYE 81 ++ G+ P +P +G L KD + LT + + +G +FT+ G + VL Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPH 59 Query: 82 VVKEALIDLGEEFSGRGH-FPLAERANRGFGIVFS---NGKRWKE---IRRFSLMTLRNF 134 + + + L ER +S R K R +T + Sbjct: 60 SYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMY 119 Query: 135 GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQF 194 + L + S +L S F R Y Sbjct: 120 TNLHAVL----------LGD--ATEAGSGWHEMGLLDF-------SYSFLLRAGYLTLYG 160 Query: 195 LNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLL----KNLAFMESDILEKVKE 250 + + + +E+ + + F + P L K+ L K+ Sbjct: 161 IEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLS 220 Query: 251 HQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADL-LGAGTETTSTTLRYA 309 + +++ +L+ +E+ + E + A L L A + Sbjct: 221 PARLARRAHRSKWLESYLLHLEEMGVS-------EEMQARALVLQLWATQGNMGPAAFWL 273 Query: 310 LLLLLKHPEVTAKVQEEIERVVGRNRSPCMQD-------RGHMPYTDAVVHEVQRYIDLI 362 LL LLK+PE A V+ E+E ++ + P Q P D+V+ E R Sbjct: 274 LLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT--A 331 Query: 363 PTSLPHAVTCDVKF-----RNYLIPKGTTILTSL-TSVLHDNKEFPNPEMFDPRHFLDEG 416 + V D+ R + + +G +L S D + + +PE+F FL+ Sbjct: 332 APFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPD 391 Query: 417 GNFKK---------SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL 467 G+ KK NY MP+ AG C+G A + F+ +L + +L+ + ++ Sbjct: 392 GSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEI 451 Query: 468 DTTPVVN-GFASVPPFYQL 485 + GF + P + + Sbjct: 452 PEFDLSRYGFGLMQPEHDV 470 >2WIY-A nrPDB Length = 394 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 39/244 (15%), Positives = 74/244 (30%), Gaps = 32/244 (13%) Query: 237 LAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLG 296 A + +V E E +N D L + E T + T Sbjct: 179 AAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAA------RAGEITESEAIATILVFYA 232 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQ 356 G + + L + PEV + + A+++E+ Sbjct: 233 VGHMAIGYLIASGIELFARRPEVFTAFRNDESA------------------RAAIINEMV 274 Query: 357 RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416 R S T DV+ LI G+ I + + D + F +P++FD Sbjct: 275 RMDPP-QLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR----- 328 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGF 476 ++ + F G C G+ ++R E + + + L + + + Sbjct: 329 --PPAASRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERIELAEEPTVAHNDFARRY 386 Query: 477 ASVP 480 +P Sbjct: 387 RKLP 390 >4FB2-A nrPDB Length = 398 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 59/417 (14%), Positives = 124/417 (29%), Gaps = 79/417 (18%) Query: 75 VVLHGYEVVKEALIDLGEEFSGRGH-FPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 133 V+ GY+ + +A+I + FS +G FP E + + K+ R+ Sbjct: 47 WVVAGYKEI-QAVIQNTKAFSNKGVTFPRYETGEFELMMAGQDDPVHKKYRQLVAKPFSP 105 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF-----QKRFD 188 +++++ L++ R T++ P + ++ + Sbjct: 106 --EATDLFTEQLRQSTNDLIDA-RIELGEGDAATWLANEIPARLTAILLGLPPEDGDTYR 162 Query: 189 YKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV 248 ++ P ++ L ++ + Sbjct: 163 RWVWAITHVEN---------------------------PEEGAEIFAELVAHARTLIAER 195 Query: 249 KEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRY 308 + NP + I +I + + ++ + ++L+ LL G + T+ L Sbjct: 196 R--------TNPGNDIMSRVIMSKIDGES----LSEDDLIGFFTILLLGGIDNTARFLSS 243 Query: 309 ALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPH 368 L E+ ++ E + V E+ R+ Sbjct: 244 VFWRLAWDIELRRRLIAHPELI------------------PNAVDELLRFYGPAMVG--R 283 Query: 369 AVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPF 428 VT +V + + G T + D F +P+ N + Sbjct: 284 LVTQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIER---------TPNRHLSL 334 Query: 429 SAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDT-TPVVNGFASVPPFYQ 484 G C+G L R+E + +T L+ SL K+ + V G VP + Sbjct: 335 GHGIHRCLGAHLIRVEARVAITEFLKRIPEFSLDPNKECEWLMGQVAGMLHVPIIFP 391 >3BUJ-A nrPDB Length = 397 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 64/431 (14%), Positives = 127/431 (29%), Gaps = 71/431 (16%) Query: 67 LYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR------GFGIVFSNGKRW 120 ++ G R+ + + V+ L D +G F G I+F + Sbjct: 28 VHRGAHRVWYVSRFADVRAVLGDERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEPDH 87 Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180 +R + R +E + L L +V+ Sbjct: 88 GRLRGVVGPAFSPSAL--RRLEPVIAGTVDDL-------------LRPALARGAMDVVDE 132 Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240 + + + L L+ + V + G + ++ Sbjct: 133 L----AYPLALRAVLGLLGLPAADWGAVGRWSRDVGRTLDR------GASAEDMRRGHAA 182 Query: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300 ++ + V+ D + L + + + +V T + G E Sbjct: 183 IAEFADYVERALARRRREGGEDLLALMLDA------HDRGLMSRNEIVSTVVTFIFTGHE 236 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360 T ++ + A+L LL HP+ ++ + V E RY Sbjct: 237 TVASQVGNAVLSLLAHPDQLDLLRRRPD------------------LLAQAVEECLRYDP 278 Query: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420 + ++ + DV+ R + + ++ + D + + P+ FD Sbjct: 279 SVQSNT-RQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIER--------- 328 Query: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN--FNLKSLIDPKDLDTTPVVNGFAS 478 M F AG R C+G LAR +L + + + L D + G AS Sbjct: 329 DPVPSMSFGAGMRYCLGSYLARTQLRAAVAALARLPGLRLGCASDALAYQPRTMFRGLAS 388 Query: 479 VPPFYQLCFIP 489 +P + F P Sbjct: 389 LP----IAFTP 395 >3B98-A nrPDB Length = 475 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 90/505 (17%), Positives = 163/505 (32%), Gaps = 70/505 (13%) Query: 19 IWRQSSG--------RGKLPPGPTP-LPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYF 69 + +++S R PP +P +G+ L+ KD +K LT + + +G +FT+ Sbjct: 1 MAKKTSSVLYGRRTRRRNEPPLDKGMIPWLGHALEFG-KDAAKFLTRMKEKHGDIFTVRA 59 Query: 70 GLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLM 129 + VL L D+ L +R I+ S+ ++ R Sbjct: 60 AGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFN--MILPSHNPESEKKRAEMHF 117 Query: 130 TLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDY 189 + S+++ + L + N+ S++F+ + Sbjct: 118 QGASLTQLSNSMQN--------NLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGY-- 167 Query: 190 KDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVK 249 L + N N S QI F P + E I + Sbjct: 168 -----LTVFGAENNN----SAALTQIYEEFRRFDKLLPKLART---TVNKEEKQIASAAR 215 Query: 250 EHQESMD-----INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304 E PR+ +L K+ Q++ + ++ + + G Sbjct: 216 EKLWKWLTPSGLDRKPRE--QSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQG--NAGP 271 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364 + + LL HPE V+EEI+ G + + + P D+V+ E R Sbjct: 272 AAFWVMGYLLTHPEALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLT--AAA 326 Query: 365 SLPHAVTCDVKF-----RNYLIPKGTTILTSL-TSVLHDNKEFPNPEMFDPRHFLDEGGN 418 + VT D K + Y + +G + S D + PEMF FL+ Sbjct: 327 LITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRT 386 Query: 419 FKK---------SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDT 469 KK +P+ +C G A + + IL F+++ + Sbjct: 387 EKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPL 446 Query: 470 T-PVVNGFASVPP------FYQLCF 487 P GF + P Y++ F Sbjct: 447 VDPSRYGFGILQPAGDLEIRYRIRF 471 >5D3U-A nrPDB Length = 427 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 48/275 (17%), Positives = 80/275 (29%), Gaps = 40/275 (14%) Query: 212 WIQICNNFPTIIDYFPGTHNK------LLKNLAFMESDILEKVKEHQESMDINNPRDFID 265 + TI+ YF G ++ +L+ L + + E ++ + + D + Sbjct: 183 LGFLIPRVNTIMTYFSGPKDQPVTQEIILEKLTDLHTYASELLQGMRGKVLP----DTVI 238 Query: 266 CFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQE 325 L + E T+ L + L TT +L L ++P + Sbjct: 239 ARLAAAQDGLTETTPEQTVHQLALVFIALFAP---TTPGSLSSGTLAFARNPRQVERFLA 295 Query: 326 EIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGT 385 + V D +EV RY + DV+ I G Sbjct: 296 DQACV------------------DNTANEVLRYNASNQFTW-RVAAKDVEMGGVRIEAGQ 336 Query: 386 TILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMEL 445 T+ L S D F P FD S + F G C+ L ++L Sbjct: 337 TLALFLGSANRDANMFERPNDFDLDR--------PNSARHLSFGQGVHACLAAQLISLQL 388 Query: 446 FLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480 F +L F + S+P Sbjct: 389 KWFYVALLNRFPGIRTAGEPIWNENLEFRSLRSLP 423 >3OFT-A nrPDB Length = 396 Score = 117 bits (294), Expect = 9e-27, Method: Composition-based stats. Identities = 80/419 (19%), Positives = 126/419 (30%), Gaps = 76/419 (18%) Query: 62 GPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVF----SNG 117 G V++ G + +VV+E L E S LA G + F +G Sbjct: 38 GLVWSTANGGH--WIAARGDVVRE-LWGDAERLS---SQCLAVTPGLGKVMQFIPLQQDG 91 Query: 118 KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG-CAPCN 176 K R + L ++E +VQ AR L+E LR CD P N Sbjct: 92 AEHKAFRTPVMKGLA--SRFVVALEPKVQAVARKLMESLR--PRGSCDFVSDFAEILPLN 147 Query: 177 VICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKN 236 + FL L++ P + + ++ Sbjct: 148 I----------------FLTLID----------VPLEDRPRLRQLGVQLTRPDGSMTVEQ 181 Query: 237 LAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLG 296 L D L E + + P D + ++ + +T++ +LL Sbjct: 182 LKQAADDYLWPFIEKRMA----QPGDDLFSRILSEPVGGRP----WTVDEARRMCRNLLF 233 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQ 356 G +T + + L L +HPE ++E + + A E+ Sbjct: 234 GGLDTVAAMIGMVALHLARHPEDQRLLRERPDLI------------------PAAADELM 275 Query: 357 RYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416 R + ++ DV I KG + D F PE L Sbjct: 276 RRYPTV--AVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGL--- 330 Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNG 475 G CVG GLARME+ +FL L +L K + G Sbjct: 331 ----APIRHTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVG 385 >6FYJ-A nrPDB Length = 421 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 68/414 (16%), Positives = 136/414 (32%), Gaps = 58/414 (14%) Query: 63 PVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFP--LAERANRGFGIVFSNGKRW 120 +F ++ + + G E E D E+F + P + + G+ +G+ Sbjct: 39 DIFETRLLGKKAICMGGKEAA-EIFYDT-EKFKRKDAAPNRVVQTLFGKNGVQALDGQTH 96 Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180 K + + + +E + E+ K D + A ++C Sbjct: 97 KHRKEMFMSIMSP-----DELEKLTDITKKQW--EIAVDKWEQMDKVILYEEAK-EIMCR 148 Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240 Q N +++L +N+ + + G + L ++ Sbjct: 149 TACQ---WAGVPVQENEVKRLTKNLGAMFESAAAV------------GLKHWLGRHARNY 193 Query: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300 E +E++ + +N P + + N T VI + A Sbjct: 194 EEIWIEELIDRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVEVINILRPIVA--- 250 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360 + + + L L +PE K++ G Y+ V EV+R+ Sbjct: 251 -IAIFINFIALALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVRRFYP 292 Query: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420 P + V D ++ Y +GT L L HD + + NP++F P F G+ Sbjct: 293 FFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGS-- 349 Query: 421 KSNYFMPFSAGK----RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTT 470 F+P G C GE + + + L ++ + + + +DL + Sbjct: 350 -PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYE--VPDQDLSFS 400 >2QBO-A nrPDB Length = 421 Score = 109 bits (273), Expect = 3e-24, Method: Composition-based stats. Identities = 74/419 (17%), Positives = 133/419 (31%), Gaps = 71/419 (16%) Query: 64 VFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEI 123 V+T G + ++++EA D S P F + E Sbjct: 55 VWTRCNGGH--WIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPTSMDPP---EQ 109 Query: 124 RRFSLMTLRNFGM-GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 R+F + + GM +E+R+QE A L+E LR C+ Sbjct: 110 RQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQ-----------------CNFT 152 Query: 183 FQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMES 242 + + F+ L E+I + Q+ P + + Sbjct: 153 EDYAEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTR---------PDGSMTFAEAKEALYD 203 Query: 243 DILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETT 302 ++ +++ ++ + I + Q T + LL G +T Sbjct: 204 YLIPIIEQRRQKPGTDA---------ISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTV 254 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLI 362 L +++ L K PE ++ E ER+ A E+ R L+ Sbjct: 255 VNFLSFSMEFLAKSPEHRQELIERPERI------------------PAACEELLRRFSLV 296 Query: 363 PTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS 422 +T D +F + KG IL D +E P D ++ Sbjct: 297 ADG--RILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHVD---------FSRQK 345 Query: 423 NYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTP-VVNGFASVP 480 F G +C+G+ LAR E+ + L L S+ + +V+G ++P Sbjct: 346 VSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALP 404 >5OMS-A nrPDB Length = 409 Score = 108 bits (269), Expect = 6e-24, Method: Composition-based stats. Identities = 60/358 (16%), Positives = 105/358 (29%), Gaps = 49/358 (13%) Query: 101 PLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 P R I+ NG ++R L+ + R I+D V+ AR +E Sbjct: 71 PAGGRTFGHPAIIGVNGDIHADLRSMVEPALQPAEV-DRWIDDLVRPIARRYLERFEN-- 127 Query: 161 ASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFP 220 D L C + ++ L E + R + + F Sbjct: 128 ----DGHAELVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLNRSFTNAAVDENGEFA 183 Query: 221 TIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQS 280 + G K + + +++K EH + D + + Sbjct: 184 NPEGFAEGDQAKA--EIRAVVDPLIDKWIEHPD-----------DSAISHWLHDGMPPGQ 230 Query: 281 EFTIENLVITA-ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 339 E + T LLGA E + L+ L PE +V ++ Sbjct: 231 TRDREYIYPTIYVYLLGAMQEP-GHGMASTLVGLFSRPEQLEEVVDDP------------ 277 Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNK 399 + E R+ I ++ T V +P GT ++ S S HD Sbjct: 278 ------TLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTG 331 Query: 400 EFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 457 ++ P +D + + F AG C G A + + L + + Sbjct: 332 KYEAPSQYD---------LHRPPLPHLAFGAGNHACAGIYFANHVMRIALEELFEAIP 380 >5KYO-A nrPDB Length = 430 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 39/238 (16%), Positives = 74/238 (31%), Gaps = 36/238 (15%) Query: 241 ESDILEKVKEHQE---SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGA 297 D+ ++ +E+ P + + +I E ++ EN+ +L Sbjct: 215 LDDVTKQFREYLRPVIEARRIKPGEDMISRMINGEV-GGRPLTDIEAENI---CIQVLVG 270 Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQR 357 G +T L + L K + + + + D + E R Sbjct: 271 GLDTVVNMLGFTFSHLAKDHALRRAIAADPSLI------------------DDALLEFFR 312 Query: 358 YIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG 417 ++ ++ V D +F L+ G ++ V D+ +P F Sbjct: 313 RFPVVSSA--REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR------ 364 Query: 418 NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNG 475 K+ F G C G LARME+ + L + D L + + G Sbjct: 365 ---KARQHSTFGKGSHTCPGAHLARMEMKVVLREWFARIPEFRIEDDAPLRYSNGIVG 419 >5YHJ-A nrPDB Length = 413 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 77/413 (18%), Positives = 137/413 (33%), Gaps = 62/413 (15%) Query: 64 VFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFP--LAERANRGFGIVFSNGKRWK 121 +F ER++ L G E E D +F+ + P L + G+ +G Sbjct: 36 IFESRLLGERVICLGGEEAA-EVFYD-ANKFTRQDAAPKRLLKTLFGEGGVQTLDGSEH- 92 Query: 122 EIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSI 181 R+ M+L R + +E + +E + I +C Sbjct: 93 THRKQMFMSLMTKENIDRLLRLTYREWNQ--IERM----GEEIVLYDIAQEVLMKAVCEW 146 Query: 182 IFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME 241 + + M L E+ + T+ + K + E Sbjct: 147 SGVPLAKEEVGKRTEEMRLLFESGTSLG------------------PTYLQGRKARSSAE 188 Query: 242 SDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTET 301 I + VKE + + + N + F +++ E E +V + T Sbjct: 189 VWIRQMVKEVRSNRLLPNEHTALYEF-----SWHRDESGELLPEEVVAVEVLNILRPTVA 243 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDL 361 S + + +L L + P+V +V +RG + T+ V EV+R+ Sbjct: 244 ISVYVLFTVLALHQFPDVKEQV-----------------ERGEVSKTE-FVQEVRRFYPF 285 Query: 362 IPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK 421 P + T D ++ Y P+GT L L HD + P+ FDP F D + Sbjct: 286 FPVAAARVKT-DFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWKES--- 341 Query: 422 SNYFMPFSAGK----RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTT 470 F+P G C GE + L + + + + P+DL + Sbjct: 342 PFNFIPQGGGDVDFGHRCAGEHVTIAILAQVIELFTKEY--AYTVPPQDLSYS 392 >3NV6-A nrPDB Length = 452 Score = 95.9 bits (237), Expect = 4e-20, Method: Composition-based stats. Identities = 67/424 (15%), Positives = 135/424 (31%), Gaps = 65/424 (15%) Query: 64 VFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGI-VFSNGKRWKE 122 ++T + G + + VKE D FS F E + + + Sbjct: 90 IWTPFTGGH--WIATNGDTVKEVYSDP-TRFSSEVIFLPKEAGEKYQMVPTKMDPPEHTP 146 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 R+ L + R +ED+V+E A L++ C Sbjct: 147 YRKALDKGLNLAKI--RKVEDKVREVASSLIDSFAARGE-----------------CDFA 187 Query: 183 FQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMES 242 + + F+ L + E+I ++S Q+ P L+ Sbjct: 188 AEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEGNT----PEEMATDLEAGNNGFY 243 Query: 243 DILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETT 302 ++ + + D D + ++ E + + + LL G +T Sbjct: 244 AYVDPIIRARVGGD----GDDLITLMVNSEINGE----RIAHDKAQGLISLLLLGGLDTV 295 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLI 362 L + ++ L +HPE+ A+++ + +++ E+ R ++ Sbjct: 296 VNFLSFFMIHLARHPELVAELRSDPLKLMRGA------------------EEMFRRFPVV 337 Query: 363 PTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS 422 + V D +++ + +G IL D+ P P D ++S Sbjct: 338 SEA--RMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLD---------FSRRS 386 Query: 423 NYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN-LKSLIDPKDLDTTPVVNGFASVPP 481 F G C G LARME+ + L L+ + + +V +VP Sbjct: 387 ISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPL 446 Query: 482 FYQL 485 + + Sbjct: 447 VWPI 450 >2ZQJ-A nrPDB Length = 417 Score = 92.4 bits (228), Expect = 4e-19, Method: Composition-based stats. Identities = 72/455 (15%), Positives = 142/455 (31%), Gaps = 61/455 (13%) Query: 39 IGNILQIDIKDVSKSLTNLSKIY-GPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGR 97 + N L + + + N ++ Y +F + + + G E K + Sbjct: 11 LDNSLTLLKEG-YLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNA 69 Query: 98 GHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELR 157 + + I +G R+ ++L KR + + + EE + V R Sbjct: 70 LPKRVQKSLFGVNAIQGMDGSAH-IHRKMLFLSLMTPPHQKR-LAELMTEEWKAAVT--R 125 Query: 158 KTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN 217 KA C V C + + ++ + +I + + Sbjct: 126 WEKADEVVLFEEAKEILCRVAC--------------YWAGVPLKETEVKERADDFIDMVD 171 Query: 218 NFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQN 277 F + H K + E I +++ + + + +++ Sbjct: 172 AFGAVGP----RHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQ 227 Query: 278 QQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSP 337 S L+ ++ S L ++ L L +HP+ ++ Sbjct: 228 LDSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKEWLRS------------ 270 Query: 338 CMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD 397 G+ + V EV+RY P L V D + N KGT++L L HD Sbjct: 271 -----GNSREREMFVQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLLDLYGTNHD 324 Query: 398 NKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK----RICVGEGLARMELFLFLTFIL 453 + + +P+ F P F + N +P G C GEG+ + L F++ Sbjct: 325 PRLWDHPDEFRPERFAEREENLFD---MIPQGGGHAEKGHRCPGEGITIEVMKASLDFLV 381 Query: 454 QNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFI 488 D+ + A +P + F+ Sbjct: 382 HQIEY-------DVPEQSLHYSLARMPSLPESGFV 409 >4C9K-A nrPDB Length = 421 Score = 89.4 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 36/184 (19%), Positives = 67/184 (36%), Gaps = 34/184 (18%) Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359 +T L + ++ L +HPE A+++ E + V E+ R Sbjct: 259 DTVVNFLGFMMIYLSRHPETVAEMRREPLK------------------LQRGVEELFRRF 300 Query: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419 ++ + V D++F ++ +G IL D++ +P D Sbjct: 301 AVVSDA--RYVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMTVDLSR-------- 350 Query: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQN---FNLKSLIDPKDLDTTPVVNGF 476 + F+ G C G LAR+E+ + L L F LK P + + +V Sbjct: 351 -RDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVP--IYHSGIVAAV 407 Query: 477 ASVP 480 ++P Sbjct: 408 ENIP 411 >5M0P-A nrPDB Length = 428 Score = 88.2 bits (217), Expect = 8e-18, Method: Composition-based stats. Identities = 66/414 (15%), Positives = 125/414 (30%), Gaps = 51/414 (12%) Query: 64 VFTLY-FGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKE 122 VF G + VV+ G E + + + G + I +GK+ + Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMFYNNDVVQREGMLPKRIVNTLAGKGAIHTVDGKKHVD 100 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 R+ M+L G R L L + + +++ Sbjct: 101 -RKALFMSLMTEGN---------LNYVRELTRTLWHANTQRMESMDEVNIYRESIVLLTK 150 Query: 183 FQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMES 242 R+ ++ E+I ++T + ++F + F K K Sbjct: 151 VGTRWAG--------VQAPPEDIERIATDMDIMIDSFRALGGAF--KGYKASKEARRRVE 200 Query: 243 DILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETT 302 D LE+ +I+ P E N T ++ L A Sbjct: 201 DWLEEQIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDLMNTFRPLIA----I 256 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLI 362 + + + L + ++P K++ E + Y EV+RY + Sbjct: 257 NRFVSFGLHAMNENPITREKIKSEPD------------------YAYKFAQEVRRYYPFV 298 Query: 363 PTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS 422 P LP D+ F+ IP G + + HD + +P F P F G+ Sbjct: 299 PF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDGS---P 354 Query: 423 NYFMPFSAGK----RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472 +P G C GE + + + + + + ++D + Sbjct: 355 FDLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQDLEVDLNSI 408 >3AWQ-A nrPDB Length = 415 Score = 85.9 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 28/151 (18%), Positives = 53/151 (35%), Gaps = 15/151 (9%) Query: 342 RGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEF 401 Y + V EV+R+ P + + D ++ P+G ++ L HD + Sbjct: 268 VQQPDYAELFVQEVRRFYPFFPAVVAR-ASQDFEWEGMAFPEGRQVVLDLYGSNHDAATW 326 Query: 402 PNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK----RICVGEGLARMELFLFLTFILQNFN 457 +P+ F P F + S F+P G C GE + + + ++ Sbjct: 327 ADPQEFRPERFRAWDED---SFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMR 383 Query: 458 LKSLIDPKDLDTTPVVNGFASVPPFYQLCFI 488 D+ + FA +P + F+ Sbjct: 384 Y-------DVPDQDLSIDFARLPALPKSGFV 407 >2RCM-A nrPDB Length = 495 Score = 77.4 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 56/154 (36%), Gaps = 17/154 (11%) Query: 318 EVTAKVQEEIERVVGRNR-SPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKF 376 +V ++ EEI V+ N M M T +VV+E R+ + D+ Sbjct: 316 QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGR-AKKDLVI 374 Query: 377 RNY----LIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK 432 ++ + G + D K F + F P F+ E G +K + +S G Sbjct: 375 ESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEG--EKLLRHVLWSNGP 432 Query: 433 ---------RICVGEGLARMELFLFLTFILQNFN 457 + C G+ + LF+ I + ++ Sbjct: 433 ETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYD 466 >3DBM-A nrPDB Length = 473 Score = 67.4 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 33/168 (19%), Positives = 64/168 (38%), Gaps = 20/168 (11%) Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVVGR--NRSPCMQDRGHMPYTDAVVHEVQRYIDL 361 TL++ L ++ + EEI + + + ++ MP T +VV+E R Sbjct: 287 NTLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPP 343 Query: 362 IPTSLPHA---VTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN 418 +P A T + + + KG + D K F PE + P F+ +G Sbjct: 344 VPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEA 403 Query: 419 FKKSNYFMPFSAGK---------RICVGEGLARMELFLFLTFILQNFN 457 K ++ +S G + C G+ + LF+ + + ++ Sbjct: 404 LLK---YVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 58.9 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 41/117 (35%), Gaps = 19/117 (16%) Query: 295 LGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHE 354 L AG E T+ T+ A+L + P + ++ ++ V E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAA------------------AQRTVAE 261 Query: 355 VQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRH 411 V R T +V+ ++I +G ++ + + D + F P+ D Sbjct: 262 VLRL-HPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDR 317 >4YXC-B nrPDB Length = 227 Score = 33.1 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 16/92 (17%), Positives = 37/92 (40%), Gaps = 7/92 (7%) Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360 TT+ + A+ L +V+ +Q +I+ ++ ++ + T + E+ R Sbjct: 119 TTTKSAADAVFQQLGGGDVSGAMQ-DIDLIMDIPVKLTVE----LGRTRMTIKELLRLTQ 173 Query: 361 LIPTSLPHAVTC--DVKFRNYLIPKGTTILTS 390 +L D+ YLI +G ++ + Sbjct: 174 GSVVALDGLAGEPLDILINGYLIAQGEVVVVA 205 >4DJD-D nrPDB Length = 323 Score = 32.0 bits (71), Expect = 0.65, Method: Composition-based stats. Identities = 16/46 (34%), Positives = 26/46 (56%), Gaps = 10/46 (21%) Query: 289 ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRN 334 +TA LL AG +LL++HPE A+V+E I++++ N Sbjct: 286 VTATALLQAGAH----------ILLMRHPEAVARVKENIDQLMVSN 321 >4YXB-D nrPDB Length = 80 Score = 31.2 bits (69), Expect = 0.99, Method: Composition-based stats. Identities = 9/49 (18%), Positives = 18/49 (36%), Gaps = 2/49 (4%) Query: 344 HMPYTDAVVHEVQRYIDLIPTSLPHAVTC--DVKFRNYLIPKGTTILTS 390 + T + E+ R +L D+ YLI +G ++ + Sbjct: 10 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVA 58 >3GFZ-A nrPDB Length = 413 Score = 30.8 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 14/113 (12%), Positives = 34/113 (30%), Gaps = 17/113 (15%) Query: 315 KHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDV 374 +H +V +++ + D + TD + E+ R+ Sbjct: 78 RHRDVVELMRDYSAYRRFHGTGMRILDL-RLFETDGALEEILRFSTF------------- 123 Query: 375 KFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMP 427 P + L++ + D + PE P ++ + + +P Sbjct: 124 ---GVTEPVNDRMFRLLSAFIADGGRYCLPEPLQPSRWMMMPASGTAAPQHLP 173 >6CNF-R nrPDB Length = 736 Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 27/180 (15%), Positives = 59/180 (32%), Gaps = 27/180 (15%) Query: 310 LLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHA 369 L L + E A+V E I+ G + + + E + ++PT Sbjct: 338 LFYLKQFSERRARVVERIKATNGIDGENIYHEGSENETRKRKLSEAMPWSGIVPTLQNIV 397 Query: 370 VTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS-NYFMPF 428 T + G + ++ N E+ +P+ F ++ + F Sbjct: 398 ATVTL---------GCRLDLKTVALHARNAEY------NPKRFAAVIMRIREPKTTALIF 442 Query: 429 SAGKRICVGE-----------GLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFA 477 ++GK + G AR+ + +F +++++ D+ + G A Sbjct: 443 ASGKMVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLA 502 >1QN4-A nrPDB Length = 200 Score = 30.0 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 14/84 (16%), Positives = 33/84 (39%), Gaps = 12/84 (14%) Query: 406 MFDPRHFLDEGGNFKKS-NYFMPFSAGKRICVGEG-----------LARMELFLFLTFIL 453 ++P+ F ++ + F++GK +C G AR+ L Sbjct: 51 EYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEDFSKMAARKYARIVQKLGFPAKF 110 Query: 454 QNFNLKSLIDPKDLDTTPVVNGFA 477 ++F +++++ D+ + G A Sbjct: 111 KDFKIQNIVGSCDVKFPIRLEGLA 134 >3RFT-A nrPDB Length = 267 Score = 30.0 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 15/55 (27%), Gaps = 11/55 (20%) Query: 389 TSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARM 443 S H +P E P G G C GE LARM Sbjct: 106 IVFASSNHTIGYYPQTERLGPDVPARPDGL-----------YGVSKCFGENLARM 149 >4HE8-H nrPDB Length = 365 Score = 29.7 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 36/113 (31%), Gaps = 12/113 (10%) Query: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300 +DI+ KEH P + +LI E + L G Sbjct: 182 LNDIVNWQKEHGWLFLYAFPAFLV--YLIASMAEAARTPFDLPEAEQE------LVGGYH 233 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVH 353 T +++++AL + ++ +G P ++ +PY + Sbjct: 234 TEYSSIKWALFQMAEYIHFITASALIPTLFLGGWTMPVLE----VPYLWMFLK 282 >5J1I-A nrPDB Length = 373 Score = 29.3 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 29/184 (15%), Positives = 62/184 (33%), Gaps = 14/184 (7%) Query: 74 MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 133 +V+ G + +E L E+ P + E ++ + LR+ Sbjct: 120 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 179 Query: 134 FGMGKRSIEDRVQE---EARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYK 190 G + + +R+Q+ E VE R+ A +L +++ Q + Sbjct: 180 ELRGAQEVGERLQQRHGERDVEVERWRERVAQ------LLERWQ-----AVLAQTDVRQR 228 Query: 191 DQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKE 250 + + L + W+Q I P ++ ++ E +LE+++ Sbjct: 229 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 288 Query: 251 HQES 254 H E Sbjct: 289 HGEK 292 >5C8J-I nrPDB Length = 207 Score = 28.9 bits (63), Expect = 5.3, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 19/36 (52%) Query: 313 LLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT 348 + K+PE+ K+QEE +R++ N M YT Sbjct: 71 MSKNPEMMEKLQEEQQRIMQLNAELMKMSFRPMIYT 106 >6FEC-u nrPDB Length = 636 Score = 28.1 bits (61), Expect = 9.1, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 26/66 (39%), Gaps = 3/66 (4%) Query: 317 PEVTAKVQE-EIERVVGRNRSPCMQDRGHMPY--TDAVVHEVQRYIDLIPTSLPHAVTCD 373 P +E I+R P G++PY T+ + E R +++ LP + Sbjct: 99 PTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNP 158 Query: 374 VKFRNY 379 + + + Sbjct: 159 ERLKGF 164 >5ZHI-A nrPDB Length = 238 Score = 28.1 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 8/51 (15%), Positives = 18/51 (35%), Gaps = 8/51 (15%) Query: 361 LIPTSLPHAVTCDVKFRNYLIPKG--------TTILTSLTSVLHDNKEFPN 403 ++ + +V +Y++P G +L L VL + + Sbjct: 118 VVQDAARRMRVEEVSIGDYVLPGGESAAVVMVEAVLRLLAGVLGNPASHQD 168 >5L9W-B nrPDB Length = 732 Score = 28.1 bits (61), Expect = 9.9, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 31/85 (36%), Gaps = 4/85 (4%) Query: 246 EKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSE----FTIENLVITAADLLGAGTET 301 ++V E + N P I+ LI +E+ + E++ L+ G Sbjct: 116 QRVAERRNIAVQNKPLPLIERDLILGVRERIDSSGSVVRPLDEEDVRTKLRMLMDRGARA 175 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEE 326 +L ++ + V ++EE Sbjct: 176 IVVSLLWSFMNPAHEKRVREIIREE 200 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.133 0.359 Lambda K H 0.267 0.0408 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,242,253 Number of Sequences: 36641 Number of extensions: 741846 Number of successful extensions: 3010 Number of sequences better than 10.0: 183 Number of HSP's better than 10.0 without gapping: 259 Number of HSP's successfully gapped in prelim test: 80 Number of HSP's that attempted gapping in prelim test: 2064 Number of HSP's gapped (non-prelim): 363 length of query: 490 length of database: 10,336,785 effective HSP length: 101 effective length of query: 389 effective length of database: 6,636,044 effective search space: 2581421116 effective search space used: 2581421116 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.1 bits)