BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P32577 (450 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1K9A-A nrPDB 940 0.0 1BYG-A nrPDB 567 e-162 2FO0-A nrPDB 320 8e-88 6F3F-A nrPDB 302 2e-82 2H8H-A nrPDB 302 2e-82 4XEY-B nrPDB 300 7e-82 1AD5-A nrPDB 291 3e-79 4XI2-A nrPDB 276 1e-74 4CSV-A nrPDB 245 3e-65 2XYN-A nrPDB 243 2e-64 6NPU-A nrPDB 238 6e-63 4E93-A nrPDB 229 3e-60 2PL0-A nrPDB 229 3e-60 2HK5-A nrPDB 226 2e-59 3A4O-X nrPDB 225 3e-59 4Y93-A nrPDB 224 4e-59 6E4F-A nrPDB 221 5e-58 3SXS-A nrPDB 219 2e-57 5SYS-A nrPDB 218 3e-57 2DQ7-X nrPDB 217 8e-57 5H2U-A nrPDB 213 2e-55 4XCU-A nrPDB 213 2e-55 3TT0-A nrPDB 209 2e-54 3GQL-A nrPDB 209 3e-54 5A46-A nrPDB 207 5e-54 3QGY-A nrPDB 207 5e-54 4K33-A nrPDB 206 2e-53 2PSQ-A nrPDB 202 3e-52 5EG3-A nrPDB 201 7e-52 3KUL-B nrPDB 199 3e-51 4P5Q-A nrPDB 196 2e-50 4EBW-A nrPDB 195 3e-50 4PDO-A nrPDB 194 5e-50 2Y6O-A nrPDB 194 7e-50 2J0K-A nrPDB 193 1e-49 2R2P-A nrPDB 192 3e-49 3DKO-A nrPDB 192 3e-49 1JPA-A nrPDB 192 3e-49 4H1J-A nrPDB 189 1e-48 3PLS-A nrPDB 189 3e-48 3CJF-A nrPDB 187 6e-48 5X02-A nrPDB 185 3e-47 5MJB-A nrPDB 185 4e-47 2VWV-A nrPDB 185 4e-47 4XUF-A nrPDB 185 4e-47 4XLV-A nrPDB 184 6e-47 5HLW-A nrPDB 184 7e-47 3BEA-A nrPDB 184 8e-47 3I81-A nrPDB 183 1e-46 1FVR-A nrPDB 183 2e-46 3C1X-A nrPDB 182 2e-46 4R7H-A nrPDB 182 3e-46 2OGV-A nrPDB 181 4e-46 6GQK-A nrPDB 181 6e-46 5GRN-A nrPDB 181 7e-46 5U6C-A nrPDB 181 7e-46 5L6P-A nrPDB 181 7e-46 4HZS-A nrPDB 181 8e-46 1U54-B nrPDB 180 9e-46 5AMN-A nrPDB 179 3e-45 3KRL-A nrPDB 178 5e-45 3BBT-B nrPDB 176 2e-44 3AOX-A nrPDB 175 5e-44 5C26-A nrPDB 174 6e-44 4FL3-A nrPDB 174 7e-44 5FM2-A nrPDB 174 8e-44 3ZBF-A nrPDB 172 2e-43 1U59-A nrPDB 172 4e-43 5KMM-A nrPDB 169 2e-42 2OZO-A nrPDB 169 2e-42 5U6B-A nrPDB 169 2e-42 3PP0-A nrPDB 169 3e-42 3G0E-A nrPDB 168 4e-42 2W1I-A nrPDB 167 8e-42 3IO7-A nrPDB 167 9e-42 3LZB-A nrPDB 165 3e-41 3QUP-A nrPDB 165 4e-41 6DBM-A nrPDB 163 2e-40 5GNK-A nrPDB 162 3e-40 3V5Q-A nrPDB 159 2e-39 4OLI-A nrPDB 159 2e-39 4E20-A nrPDB 159 3e-39 4LRM-A nrPDB 158 5e-39 1LUF-A nrPDB 157 1e-38 4AT3-A nrPDB 157 1e-38 3LMG-A nrPDB 157 1e-38 6DBN-A nrPDB 156 2e-38 3HNG-A nrPDB 156 2e-38 5WNO-A nrPDB 150 1e-36 3ZZW-A nrPDB 150 2e-36 4HVI-A nrPDB 149 2e-36 4RT7-A nrPDB 148 5e-36 3VHK-A nrPDB 147 8e-36 6FEX-A nrPDB 147 1e-35 6FER-A nrPDB 145 5e-35 5VO2-A nrPDB 143 2e-34 6BSD-A nrPDB 142 2e-34 3PPZ-A nrPDB 140 1e-33 5X5O-A nrPDB 133 2e-31 4UYA-A nrPDB 133 2e-31 3DTC-A nrPDB 130 1e-30 4UY9-A nrPDB 130 2e-30 4NEU-A nrPDB 122 3e-28 4YFF-A nrPDB 121 5e-28 3OMV-A nrPDB 120 2e-27 5ES1-A nrPDB 118 6e-27 5HVK-A nrPDB 116 2e-26 5HI2-A nrPDB 115 3e-26 5KZ7-A nrPDB 115 4e-26 4GS6-A nrPDB 114 1e-25 5HIE-A nrPDB 113 2e-25 2QNJ-A nrPDB 112 4e-25 4YNZ-A nrPDB 109 3e-24 2HAK-A nrPDB 108 3e-24 4TPT-A nrPDB 107 8e-24 6C9D-A nrPDB 107 1e-23 3MDY-A nrPDB 105 5e-23 4F0G-A nrPDB 103 2e-22 1PY5-A nrPDB 100 1e-21 1GRI-A nrPDB 99 4e-21 2Y4I-B nrPDB 99 5e-21 3REP-A nrPDB 98 6e-21 3Q4U-A nrPDB 97 1e-20 6AMW-A nrPDB 97 1e-20 2ABL-A nrPDB 97 1e-20 5XD6-A nrPDB 97 2e-20 6CTH-A nrPDB 96 3e-20 3MY0-A nrPDB 95 5e-20 4CZT-A nrPDB 94 1e-19 5UIU-A nrPDB 94 1e-19 3DAK-A nrPDB 94 2e-19 4APC-A nrPDB 93 2e-19 5DBX-A nrPDB 92 3e-19 3DXN-A nrPDB 92 4e-19 3HZT-A nrPDB 92 5e-19 4CQG-A nrPDB 91 8e-19 3COM-A nrPDB 91 1e-18 3MA6-A nrPDB 90 2e-18 4WNO-A nrPDB 90 2e-18 6J5U-C nrPDB 89 3e-18 4LG4-A nrPDB 89 3e-18 5JN2-A nrPDB 89 4e-18 6AO5-A nrPDB 89 5e-18 1FOT-A nrPDB 88 7e-18 6QAU-A nrPDB 88 7e-18 3LIJ-A nrPDB 88 9e-18 4QMW-A nrPDB 87 1e-17 4EQM-A nrPDB 87 1e-17 5WNL-A nrPDB 87 1e-17 4D2V-A nrPDB 87 1e-17 4RGJ-A nrPDB 86 2e-17 4FZF-B nrPDB 86 2e-17 5TOS-A nrPDB 86 3e-17 4L00-A nrPDB 86 4e-17 4FG9-A nrPDB 86 4e-17 3ALO-A nrPDB 85 5e-17 5F9E-A nrPDB 85 8e-17 4CFH-A nrPDB 85 8e-17 2JAM-A nrPDB 85 8e-17 3ORZ-A nrPDB 84 9e-17 5X3F-B nrPDB 84 1e-16 5USZ-A nrPDB 84 1e-16 6FD3-A nrPDB 84 2e-16 3Q53-A nrPDB 84 2e-16 4UZD-A nrPDB 83 2e-16 2F57-A nrPDB 83 2e-16 4WB7-A nrPDB 83 2e-16 4D28-A nrPDB 83 3e-16 3DFA-A nrPDB 83 3e-16 4REW-A nrPDB 83 3e-16 3NCG-A nrPDB 82 4e-16 1A81-A nrPDB 82 4e-16 3ZDU-A nrPDB 82 4e-16 2JC6-A nrPDB 82 5e-16 5N23-A nrPDB 82 5e-16 2WQN-A nrPDB 82 5e-16 5D9K-A nrPDB 82 6e-16 4NST-A nrPDB 82 6e-16 4RED-A nrPDB 82 7e-16 2YZA-A nrPDB 82 7e-16 3D2K-A nrPDB 82 7e-16 2JDO-A nrPDB 81 7e-16 3H4J-B nrPDB 81 8e-16 2XIK-A nrPDB 81 8e-16 6E2O-A nrPDB 81 9e-16 5EFQ-A nrPDB 80 1e-15 6FDY-U nrPDB 80 1e-15 3MN3-A nrPDB 80 1e-15 6CMJ-A nrPDB 80 2e-15 3PFQ-A nrPDB 80 2e-15 4M66-A nrPDB 80 2e-15 3MV5-A nrPDB 80 2e-15 2I0E-A nrPDB 80 2e-15 5KCV-A nrPDB 80 2e-15 3NIZ-A nrPDB 80 2e-15 2UV2-A nrPDB 80 3e-15 5EZV-A nrPDB 79 3e-15 3IS5-A nrPDB 79 3e-15 4RLP-A nrPDB 79 3e-15 4RA4-A nrPDB 79 3e-15 4CFF-A nrPDB 79 4e-15 4L42-A nrPDB 79 4e-15 5LPV-A nrPDB 79 5e-15 2QKW-B nrPDB 79 5e-15 4KS7-A nrPDB 79 6e-15 3TXO-A nrPDB 79 6e-15 5LPZ-A nrPDB 78 6e-15 4QTB-A nrPDB 78 8e-15 3HDN-A nrPDB 78 9e-15 4YZB-A nrPDB 77 2e-14 3Q5I-A nrPDB 77 2e-14 4JXF-A nrPDB 77 2e-14 5XZW-A nrPDB 77 2e-14 5YV8-A nrPDB 77 2e-14 3T04-A nrPDB 76 2e-14 5NGU-A nrPDB 76 3e-14 1U5R-A nrPDB 76 3e-14 2GCD-A nrPDB 76 3e-14 3MIA-A nrPDB 76 4e-14 5YKS-A nrPDB 75 4e-14 5DYK-A nrPDB 75 4e-14 4FIE-A nrPDB 75 5e-14 4JDH-A nrPDB 75 5e-14 2Q0N-A nrPDB 75 5e-14 4C0T-A nrPDB 75 6e-14 2Z7Q-A nrPDB 75 7e-14 4XBR-A nrPDB 75 8e-14 5LOH-A nrPDB 74 9e-14 2BPM-A nrPDB 74 9e-14 2F9G-A nrPDB 74 1e-13 4BBM-A nrPDB 74 1e-13 3G2F-A nrPDB 74 1e-13 4KRC-A nrPDB 74 1e-13 4B8L-A nrPDB 74 1e-13 2XNP-A nrPDB 74 1e-13 4WOV-A nrPDB 74 2e-13 4BGQ-A nrPDB 74 2e-13 3UIM-A nrPDB 73 2e-13 5C01-A nrPDB 73 2e-13 3A8W-A nrPDB 73 2e-13 6HXF-B nrPDB 73 2e-13 1CM8-A nrPDB 73 2e-13 6BDL-A nrPDB 73 2e-13 4M7I-A nrPDB 73 2e-13 4PDS-A nrPDB 73 3e-13 4OTD-A nrPDB 73 3e-13 3ORP-A nrPDB 73 3e-13 3DB8-A nrPDB 72 4e-13 5J5T-A nrPDB 72 4e-13 4I6B-A nrPDB 72 4e-13 4AGU-A nrPDB 72 5e-13 4FR4-A nrPDB 72 5e-13 4J52-A nrPDB 72 6e-13 5FET-A nrPDB 71 8e-13 2OU7-A nrPDB 71 1e-12 5G6V-A nrPDB 71 1e-12 6GU6-A nrPDB 71 1e-12 2BRG-A nrPDB 71 1e-12 3GC9-A nrPDB 70 1e-12 2X4F-A nrPDB 70 1e-12 2BUJ-A nrPDB 70 2e-12 4AN9-A nrPDB 70 2e-12 4AF3-A nrPDB 70 2e-12 4M4Z-A nrPDB 70 2e-12 1V0B-A nrPDB 70 2e-12 1KOA-A nrPDB 70 2e-12 3UTO-A nrPDB 70 3e-12 4CRS-A nrPDB 70 3e-12 3VN9-A nrPDB 69 3e-12 6CCF-A nrPDB 69 5e-12 3OHT-A nrPDB 69 5e-12 4U41-A nrPDB 69 6e-12 4MVF-A nrPDB 68 6e-12 1UA2-A nrPDB 68 7e-12 3FXW-A nrPDB 68 7e-12 2QLU-A nrPDB 68 8e-12 2WTK-C nrPDB 68 9e-12 3FME-A nrPDB 68 9e-12 4I94-A nrPDB 68 1e-11 5X8I-B nrPDB 67 1e-11 4EWQ-A nrPDB 67 1e-11 5D7A-A nrPDB 67 1e-11 5KKR-C nrPDB 67 1e-11 3EQC-A nrPDB 67 1e-11 6BFN-A nrPDB 67 2e-11 4AU8-A nrPDB 67 2e-11 4M69-B nrPDB 67 2e-11 4KIK-B nrPDB 67 2e-11 2VN9-A nrPDB 66 3e-11 4JG6-A nrPDB 66 3e-11 1S9I-A nrPDB 66 3e-11 4OW8-A nrPDB 66 3e-11 4O2Z-A nrPDB 66 3e-11 4BTF-A nrPDB 66 3e-11 5AR8-A nrPDB 66 3e-11 6CQF-A nrPDB 65 4e-11 1KOB-A nrPDB 65 5e-11 4NIF-A nrPDB 65 5e-11 4X3F-A nrPDB 65 5e-11 6B2Q-A nrPDB 65 6e-11 3SOC-A nrPDB 65 6e-11 3BHH-A nrPDB 65 6e-11 2YCR-A nrPDB 65 6e-11 2WTK-B nrPDB 65 7e-11 3QD2-B nrPDB 65 8e-11 3NYO-A nrPDB 65 8e-11 4YHJ-A nrPDB 64 1e-10 5TQX-A nrPDB 64 1e-10 1VZO-A nrPDB 64 1e-10 2W96-B nrPDB 64 1e-10 3I6U-A nrPDB 64 2e-10 3QA8-A nrPDB 64 2e-10 5IG1-A nrPDB 63 3e-10 4ZSG-A nrPDB 63 3e-10 4TNB-A nrPDB 63 3e-10 4IC8-A nrPDB 63 3e-10 3TAC-A nrPDB 63 3e-10 6E9W-A nrPDB 62 3e-10 5JZN-A nrPDB 62 4e-10 4MWI-A nrPDB 62 5e-10 4NFN-A nrPDB 62 5e-10 2W4O-A nrPDB 62 5e-10 5E8V-A nrPDB 62 5e-10 1G3N-A nrPDB 62 5e-10 4BTK-A nrPDB 62 6e-10 3OZ6-A nrPDB 62 7e-10 2V7O-A nrPDB 62 7e-10 6DTL-A nrPDB 61 8e-10 4PWN-A nrPDB 61 9e-10 3PG1-A nrPDB 61 1e-09 2A1A-B nrPDB 61 1e-09 3UC3-A nrPDB 60 1e-09 2OZA-A nrPDB 60 2e-09 4MYG-A nrPDB 60 2e-09 2VZ6-A nrPDB 60 2e-09 1NY3-A nrPDB 60 2e-09 5U6Y-A nrPDB 60 2e-09 3KK8-A nrPDB 60 2e-09 3KA0-A nrPDB 60 2e-09 4B6L-A nrPDB 60 2e-09 3C51-A nrPDB 59 3e-09 2J90-A nrPDB 59 3e-09 3E7O-A nrPDB 59 3e-09 4X7Q-B nrPDB 59 3e-09 6ED6-A nrPDB 59 4e-09 5B2L-A nrPDB 59 4e-09 2Y7J-A nrPDB 59 4e-09 2BDW-A nrPDB 59 5e-09 4QNY-A nrPDB 59 5e-09 3LM0-A nrPDB 59 5e-09 5J0A-A nrPDB 59 6e-09 3F3Z-A nrPDB 59 6e-09 3E3P-A nrPDB 58 7e-09 3SOA-A nrPDB 58 7e-09 1RPY-A nrPDB 58 7e-09 3UIU-A nrPDB 58 8e-09 1ZXE-A nrPDB 58 8e-09 2XS0-A nrPDB 58 1e-08 2AUG-A nrPDB 57 1e-08 1JNK-A nrPDB 57 1e-08 5O2B-A nrPDB 57 2e-08 5IKW-A nrPDB 57 2e-08 6FYV-A nrPDB 57 2e-08 4AW2-A nrPDB 57 2e-08 3FI2-A nrPDB 57 2e-08 3DLS-A nrPDB 57 2e-08 5FG8-A nrPDB 57 2e-08 2KK6-A nrPDB 57 2e-08 5O2C-A nrPDB 56 2e-08 3GC0-A nrPDB 56 2e-08 5UNP-A nrPDB 56 2e-08 1ZWS-A nrPDB 56 3e-08 1GBQ-A nrPDB 56 3e-08 2A27-A nrPDB 56 4e-08 2YAB-A nrPDB 56 4e-08 2HDV-A nrPDB 55 4e-08 4L68-A nrPDB 55 5e-08 5U06-A nrPDB 55 5e-08 1TKI-A nrPDB 55 6e-08 3KN6-A nrPDB 55 7e-08 5AWM-A nrPDB 55 8e-08 3GUB-A nrPDB 55 8e-08 4XZ1-A nrPDB 55 8e-08 4IAN-A nrPDB 55 9e-08 1PHK-A nrPDB 54 1e-07 4JLC-A nrPDB 54 1e-07 5TE0-A nrPDB 54 1e-07 5AP3-A nrPDB 54 2e-07 5ZTN-A nrPDB 54 2e-07 6O8B-A nrPDB 54 2e-07 2LQW-A nrPDB 54 2e-07 2ZMD-A nrPDB 54 2e-07 5UUU-A nrPDB 53 2e-07 3TKU-A nrPDB 53 2e-07 3HKO-A nrPDB 53 2e-07 6NT9-A nrPDB 53 2e-07 4EUT-A nrPDB 53 3e-07 3HMP-A nrPDB 53 3e-07 6CMQ-A nrPDB 53 3e-07 4H1O-A nrPDB 53 3e-07 4C59-A nrPDB 53 3e-07 6GVJ-A nrPDB 52 4e-07 3PVW-A nrPDB 52 4e-07 5Y86-A nrPDB 52 4e-07 1MIL-A nrPDB 52 4e-07 3QWY-A nrPDB 52 4e-07 3RP9-A nrPDB 52 4e-07 3NIE-A nrPDB 52 4e-07 4EUU-A nrPDB 52 5e-07 2WO6-A nrPDB 52 7e-07 2EYZ-A nrPDB 52 8e-07 5Z33-A nrPDB 51 8e-07 2EKX-A nrPDB 51 8e-07 3RAW-A nrPDB 51 1e-06 3N9X-A nrPDB 51 1e-06 6EAS-A nrPDB 50 1e-06 2RIO-A nrPDB 50 2e-06 4IDT-A nrPDB 50 2e-06 2EOB-A nrPDB 50 2e-06 2I6L-A nrPDB 50 3e-06 3CXL-A nrPDB 49 3e-06 3PS5-A nrPDB 49 3e-06 2B3O-A nrPDB 49 3e-06 6HV0-A nrPDB 49 4e-06 2PLE-A nrPDB 49 4e-06 5M6U-B nrPDB 49 4e-06 6BXI-A nrPDB 49 5e-06 4Y83-A nrPDB 49 6e-06 1XA6-A nrPDB 48 7e-06 4G3E-A nrPDB 48 7e-06 4PL5-B nrPDB 48 7e-06 3M42-A nrPDB 48 8e-06 6CKI-A nrPDB 48 1e-05 2PMN-X nrPDB 48 1e-05 4RC3-A nrPDB 48 1e-05 1NRV-A nrPDB 48 1e-05 2VD5-A nrPDB 48 1e-05 5AIR-A nrPDB 47 1e-05 2CRH-A nrPDB 47 1e-05 3BGP-A nrPDB 47 2e-05 5TUR-A nrPDB 47 2e-05 5GZA-A nrPDB 47 2e-05 2LCT-A nrPDB 47 2e-05 2CT4-A nrPDB 46 3e-05 5X1R-A nrPDB 46 4e-05 5VC6-A nrPDB 45 4e-05 3LLT-A nrPDB 45 4e-05 2YUP-A nrPDB 45 5e-05 1KA6-A nrPDB 45 5e-05 2H34-A nrPDB 45 6e-05 5UV4-A nrPDB 45 6e-05 1M27-A nrPDB 45 7e-05 3EB0-A nrPDB 45 8e-05 5VD3-A nrPDB 45 9e-05 5FQD-C nrPDB 44 1e-04 4LQP-A nrPDB 44 1e-04 4CRL-A nrPDB 44 2e-04 5GZ9-A nrPDB 44 2e-04 4TN6-A nrPDB 44 2e-04 2VIF-A nrPDB 43 2e-04 6O6Q-A nrPDB 43 2e-04 5CLR-A nrPDB 42 5e-04 2CS0-A nrPDB 42 5e-04 5L2Q-C nrPDB 42 6e-04 5VEI-A nrPDB 42 7e-04 2DLM-A nrPDB 41 0.001 5O0Y-A nrPDB 41 0.001 2HW6-A nrPDB 41 0.001 3GF9-A nrPDB 41 0.001 4Y12-A nrPDB 40 0.002 6C5X-D nrPDB 40 0.002 6J6I-B nrPDB 40 0.002 2X3W-D nrPDB 40 0.002 5NXJ-A nrPDB 40 0.003 3ULR-B nrPDB 40 0.003 2PZI-A nrPDB 40 0.003 3HAJ-A nrPDB 39 0.003 1X69-A nrPDB 39 0.005 3EHQ-A nrPDB 39 0.007 4BNE-A nrPDB 38 0.007 2CMW-A nrPDB 38 0.009 3JV3-A nrPDB 38 0.009 2NWM-A nrPDB 37 0.013 1WXU-A nrPDB 37 0.015 5M07-A nrPDB 37 0.017 6F55-A nrPDB 37 0.018 2CR4-A nrPDB 37 0.020 4XHH-A nrPDB 37 0.024 6DC0-A nrPDB 36 0.034 6C7Y-B nrPDB 36 0.036 3SV0-A nrPDB 36 0.036 4JGH-A nrPDB 36 0.039 5CEK-A nrPDB 36 0.040 4LFI-A nrPDB 36 0.042 5UU1-A nrPDB 35 0.055 4XHL-A nrPDB 35 0.056 1NM7-A nrPDB 35 0.059 6EQI-C nrPDB 35 0.061 2V1R-A nrPDB 35 0.067 1N5Z-A nrPDB 35 0.068 >1K9A-A nrPDB Length = 450 Score = 940 bits (2430), Expect = 0.0, Method: Compositional matrix adjust. Identities = 450/450 (100%), Positives = 450/450 (100%) Query: 1 MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII 60 MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII Sbjct: 1 MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII 60 Query: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV Sbjct: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120 Query: 121 SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQ 180 SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQ Sbjct: 121 SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQ 180 Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM 240 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM Sbjct: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM 240 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE 360 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE Sbjct: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE 360 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK Sbjct: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 Query: 421 NCWHLDAATRPTFLQLREQLEHIRTHELHL 450 NCWHLDAATRPTFLQLREQLEHIRTHELHL Sbjct: 421 NCWHLDAATRPTFLQLREQLEHIRTHELHL 450 >1BYG-A nrPDB Length = 278 Score = 567 bits (1461), Expect = e-162, Method: Compositional matrix adjust. Identities = 272/278 (97%), Positives = 276/278 (99%) Query: 173 MEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQA 232 M G+VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQA Sbjct: 1 MGGSVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQA 60 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL Sbjct: 61 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 120 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW 352 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW Sbjct: 121 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW 180 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP Sbjct: 181 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 240 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL 450 PAVY+VMKNCWHLDAA RP+FLQLREQLEHI+THELHL Sbjct: 241 PAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL 278 >2FO0-A nrPDB Length = 495 Score = 320 bits (820), Expect = 8e-88, Method: Compositional matrix adjust. Identities = 173/437 (39%), Positives = 256/437 (58%), Gaps = 19/437 (4%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74 +A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ ++ Sbjct: 44 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITPVNSLEKH 102 Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH 134 + W+HG ++R AE LL G FLVRES + PG ++ + EG+V HYRI Sbjct: 103 S------WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 156 Query: 135 A-SKLSIDEEVYFENLMQLVEHYTTDADGLCTRL--IKPKVMEGTVAAQDEFYRSGWALN 191 + KL + E F L +LV H++T ADGL T L PK + TV Y W + Sbjct: 157 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK-WEME 215 Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248 ++ + +G G++G+V G ++ VAVK +K D + FL EA+VM +++H NL Sbjct: 216 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 275 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 VQLLGV E YI+TE+M G+L+DYLR R + LL + + AMEYLE Sbjct: 276 VQLLGVCTREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 334 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVKWTAPEALREKKFS 364 NF+HR+LAARN LV E+++ KV+DFGL++ + + K P+KWTAPE+L KFS Sbjct: 335 NFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 394 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWH 424 KSDVW+FG+LLWEI ++G PYP I L V +EK Y+M+ P+GCP VY++M+ CW Sbjct: 395 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 454 Query: 425 LDAATRPTFLQLREQLE 441 + + RP+F ++ + E Sbjct: 455 WNPSDRPSFAEIHQAFE 471 >6F3F-A nrPDB Length = 455 Score = 302 bits (774), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 182/444 (40%), Positives = 250/444 (56%), Gaps = 24/444 (5%) Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71 T +A Y++ E DL F KG+ L IV T+ W G+ G IP+NYV + + Sbjct: 6 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 65 Query: 72 KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS----CEG- 124 +A W+ GKITR ++ERLL E G FLVRES G Y L VS +G Sbjct: 66 QAEE------WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 119 Query: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEF 183 V+HY+I + I F +L QLV +Y+ ADGLC RL V + Sbjct: 120 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPTSKPQTQGL 177 Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMT 241 + W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM Sbjct: 178 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 237 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +LRH LVQL V+ EE +YIVTEYM KGSL+D+L+ L L+ S + Sbjct: 238 KLRHEKLVQLYAVVSEEP--IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASG 295 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357 M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA Sbjct: 296 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 355 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++D Sbjct: 356 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 415 Query: 418 VMKNCWHLDAATRPTFLQLREQLE 441 +M CW + RPTF L+ LE Sbjct: 416 LMCQCWRKEPEERPTFEYLQAFLE 439 >2H8H-A nrPDB Length = 535 Score = 302 bits (774), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 181/444 (40%), Positives = 251/444 (56%), Gaps = 24/444 (5%) Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71 T +A Y++ E DL F KG+ L IV T+ W G+ G IP+NYV + + Sbjct: 86 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 145 Query: 72 KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS----CEG- 124 +A W+ GKITR ++ERLL E G FLVRES G Y L VS +G Sbjct: 146 QAEE------WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 199 Query: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEF 183 V+HY+I + I F +L QLV +Y+ ADGLC RL V + Sbjct: 200 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPTSKPQTQGL 257 Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMT 241 + W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM Sbjct: 258 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 317 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + + Sbjct: 318 KLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 375 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357 M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA Sbjct: 376 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 435 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++D Sbjct: 436 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 495 Query: 418 VMKNCWHLDAATRPTFLQLREQLE 441 +M CW + RPTF L+ LE Sbjct: 496 LMCQCWRKEPEERPTFEYLQAFLE 519 >4XEY-B nrPDB Length = 408 Score = 300 bits (769), Expect = 7e-82, Method: Compositional matrix adjust. Identities = 159/370 (42%), Positives = 224/370 (60%), Gaps = 12/370 (3%) Query: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS-KLSI 140 W+HG ++R AE LL G FLVRES + PG ++ + EG+V HYRI + KL + Sbjct: 12 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 71 Query: 141 DEEVYFENLMQLVEHYTTDADGLCTRL--IKPKVMEGTVAAQDEFYRSGWALNMKELKLL 198 E F L +LV H++T ADGL T L PK + TV Y W + ++ + Sbjct: 72 SSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY-DKWEMERTDITMK 130 Query: 199 QTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNLVQLLGVI 255 +G G++G+V G ++ VAVK +K D + FL EA+VM +++H NLVQLLGV Sbjct: 131 HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVC 190 Query: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315 E YI+TE+M G+L+DYLR R + LL + + AMEYLE NF+HRDL Sbjct: 191 TREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDL 249 Query: 316 AARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWS 371 AARN LV E+++ KV+DFGL++ + + K P+KWTAPE+L KFS KSDVW+ Sbjct: 250 AARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWA 309 Query: 372 FGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRP 431 FG+LLWEI ++G PYP I L V +EK Y+M+ P+GCP VY++M+ CW + + RP Sbjct: 310 FGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRP 369 Query: 432 TFLQLREQLE 441 +F ++ + E Sbjct: 370 SFAEIHQAFE 379 >1AD5-A nrPDB Length = 438 Score = 291 bits (746), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 170/443 (38%), Positives = 251/443 (56%), Gaps = 30/443 (6%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKREGVK 72 +A Y++ +DL F KGD +V + + W+KA++ R EG IP+NYV + + Sbjct: 5 VVALYDYEAIHHEDLSFQKGD--QMVVLEESGEWWKARSLATRKEGYIPSNYVARVDS-- 60 Query: 73 AGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCV----SCEGK- 125 L WF I+R+ AER L P G F++R+S G Y+L V +G Sbjct: 61 ----LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDT 116 Query: 126 VEHYRI-MYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFY 184 V+HY+I I F L +LV+HY DGLC +L P + + Q + Sbjct: 117 VKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM---SSKPQKPWE 173 Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIK-NDATAQAFLAEASVMTQ 242 + W + + LKL + +G G+FG+V + Y + KVAVK +K + +AFLAEA+VM Sbjct: 174 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 233 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L+H LV+L V+ +E +YI+TE+MAKGSL+D+L+S S L+ FS + E M Sbjct: 234 LQHDKLVKLHAVVTKEP--IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGM 291 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKK 362 ++E N++HRDL A N+LVS V K++DFGL + + K P+KWTAPEA+ Sbjct: 292 AFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVGA------KFPIKWTAPEAINFGS 345 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 F+ KSDVWSFGILL EI ++GR+PYP + +V+ +E+GY+M P+ CP +Y++M C Sbjct: 346 FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRC 405 Query: 423 WHLDAATRPTFLQLREQLEHIRT 445 W RPTF ++ L+ T Sbjct: 406 WKNRPEERPTFEYIQSVLDDFYT 428 >4XI2-A nrPDB Length = 446 Score = 276 bits (707), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 162/436 (37%), Positives = 247/436 (56%), Gaps = 24/436 (5%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72 + +A Y++ DL KG+ I+ + P W++A++K G+EG IP+NY+ + Sbjct: 5 KVVALYDYMPMNANDLQLRKGEEYFILEESNLP-WWRARDKNGQEGYIPSNYI-----TE 58 Query: 73 AGTKLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSC------EGK 125 A + + W+ +TR QAE+LL + G F+VR+S+ G YT+ V +G Sbjct: 59 AEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSK-AGKYTVSVFAKSTGEPQGV 117 Query: 126 VEHYRIMYH-ASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFY 184 + HY + S+ + E+ F + +L+ ++ ++ GL +RL P + A Sbjct: 118 IRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGL 177 Query: 185 RSG-WALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMT 241 G W ++ K+L L+ +G G+FG V G +RG VA+K I+ + ++ F+ EA VM Sbjct: 178 GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMM 237 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 L H LVQL GV +++ ++I+TEYMA G L++YLR R LL+ DVCEA Sbjct: 238 NLSHEKLVQLYGVCTKQRP-IFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEA 295 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK---EASSTQDTG-KLPVKWTAPEA 357 MEYLE F+HRDLAARN LV++ V KVSDFGL++ + T G K PV+W+ PE Sbjct: 296 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEV 355 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 L KFS+KSD+W+FG+L+WEIYS G++PY R + + +G ++ P VY Sbjct: 356 LMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYT 415 Query: 418 VMKNCWHLDAATRPTF 433 +M +CWH A RP+F Sbjct: 416 IMYSCWHEKADERPSF 431 >4CSV-A nrPDB Length = 275 Score = 245 bits (625), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 121/261 (46%), Positives = 167/261 (63%), Gaps = 8/261 (3%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCIKNDA-TAQAFLAEASVMTQLR 244 W + E+ L + +G G+FG+V G +R +VAVK +K + + FL EA +M +L+ Sbjct: 6 WEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLK 65 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H NLVQL GV +E +YI+TEYM+ GSL+DYLR + LL + V M Y Sbjct: 66 HPNLVQLYGVCTKEPP-IYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAY 124 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALRE 360 LE NF+HRDLAARN LV E+NV KV+DFGL + + + T K P+KWTAPEA+ Sbjct: 125 LESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISY 184 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 +FS KSDVW+FGILLWEI+++G+VPYP + +V+ +VE+GY+M P GCP +Y++M Sbjct: 185 NRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELML 244 Query: 421 NCWHLDAATRPTFLQLREQLE 441 CW+ RPTF + LE Sbjct: 245 QCWNKSPEERPTFAETLHALE 265 >2XYN-A nrPDB Length = 292 Score = 243 bits (619), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 120/261 (45%), Positives = 166/261 (63%), Gaps = 8/261 (3%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLR 244 W + ++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++ Sbjct: 27 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 86 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H NLVQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEY Sbjct: 87 HPNLVQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 145 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVKWTAPEALRE 360 LE NF+HRDLAARN LV E++V KV+DFGL++ + + K P+KWTAPE+L Sbjct: 146 LEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 205 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 FS KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VY++M+ Sbjct: 206 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 265 Query: 421 NCWHLDAATRPTFLQLREQLE 441 CW A RP+F + + E Sbjct: 266 ACWKWSPADRPSFAETHQAFE 286 >6NPU-A nrPDB Length = 298 Score = 238 bits (606), Expect = 6e-63, Method: Compositional matrix adjust. Identities = 115/261 (44%), Positives = 166/261 (63%), Gaps = 8/261 (3%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLR 244 W + ++ + +G G++G+V G ++ VAVK +K D + FL EA+VM +++ Sbjct: 21 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 80 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H NLVQLLGV E YI+TE+M G+L+DYLR R + LL + + AMEY Sbjct: 81 HPNLVQLLGVCTREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 139 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVKWTAPEALRE 360 LE NF+HRDLAARN LV E+++ KV+DFGL++ + + K P+KWTAPE+L Sbjct: 140 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 199 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 KFS KSDVW+FG+LLWEI ++G PYP I L V +EK Y+M+ P+GCP VY++M+ Sbjct: 200 NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 259 Query: 421 NCWHLDAATRPTFLQLREQLE 441 CW + + RP+F ++ + E Sbjct: 260 ACWQWNPSDRPSFAEIHQAFE 280 >4E93-A nrPDB Length = 377 Score = 229 bits (583), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 140/374 (37%), Positives = 206/374 (55%), Gaps = 26/374 (6%) Query: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSID 141 W+HG I R + LL +G FLVRES +Y L V +G H+ I+ L Sbjct: 15 WYHGAIPRAEVAELLV--HSGDFLVRESQG-KQEYVLSVLWDGLPRHF-IIQSLDNLYRL 70 Query: 142 EEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTI 201 E F ++ L++H + +P + V + W LN ++L L + I Sbjct: 71 EGEGFPSIPLLIDHLLSTQ--------QPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQI 122 Query: 202 GKGEFGDVMLGDYRGNK--VAVKCIKN----DATAQAFLAEASVMTQLRHSNLVQLLGVI 255 G+G FG+V G R + VAVK + D A+ FL EA ++ Q H N+V+L+GV Sbjct: 123 GRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGVC 181 Query: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315 + K +YIV E + G + +LR+ G + L LL+ D MEYLE +HRDL Sbjct: 182 TQ-KQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAAAGMEYLESKCCIHRDL 239 Query: 316 AARNVLVSEDNVAKVSDFGLTKEAS-----STQDTGKLPVKWTAPEALREKKFSTKSDVW 370 AARN LV+E NV K+SDFG+++E + ++ ++PVKWTAPEAL ++S++SDVW Sbjct: 240 AARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVW 299 Query: 371 SFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 SFGILLWE +S G PYP + + VEKG ++ P+ CP AV+ +M+ CW + R Sbjct: 300 SFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 359 Query: 431 PTFLQLREQLEHIR 444 P+F + ++L+ IR Sbjct: 360 PSFSTIYQELQSIR 373 >2PL0-A nrPDB Length = 289 Score = 229 bits (583), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 118/276 (42%), Positives = 172/276 (62%), Gaps = 8/276 (2%) Query: 176 TVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDA-TAQAF 233 T Q ++ W + + LKL++ +G G+FG+V +G Y G+ KVAVK +K + + AF Sbjct: 6 TQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAF 65 Query: 234 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 293 LAEA++M QL+H LV+L V+ +E +YI+TEYM GSLVD+L++ L + LL Sbjct: 66 LAEANLMKQLQHQRLVRLYAVVTQEP--IYIITEYMENGSLVDFLKTPSGIKLTINKLLD 123 Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLP 349 + + E M ++E N++HRDL A N+LVS+ K++DFGL + + ++ K P Sbjct: 124 MAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP 183 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD 409 +KWTAPEA+ F+ KSDVWSFGILL EI + GR+PYP + +V+ +E+GY+M PD Sbjct: 184 IKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPD 243 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 CP +Y +M+ CW RPTF LR LE T Sbjct: 244 NCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFT 279 >2HK5-A nrPDB Length = 270 Score = 226 bits (575), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 115/269 (42%), Positives = 169/269 (62%), Gaps = 8/269 (2%) Query: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIK-NDATAQAFLAE 236 AQ + + W + + LKL + +G G+FG+V + Y + KVAVK +K + +AFLAE Sbjct: 1 AQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAE 60 Query: 237 ASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296 A+VM L+H LV+L V+ +E +YI+TE+MAKGSL+D+L+S S L+ FS Sbjct: 61 ANVMKTLQHDKLVKLHAVVTKEP--IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSA 118 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKW 352 + E M ++E N++HRDL A N+LVS V K++DFGL + + T K P+KW Sbjct: 119 QIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKW 178 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 TAPEA+ F+ KSDVWSFGILL EI ++GR+PYP + +V+ +E+GY+M P+ CP Sbjct: 179 TAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP 238 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLE 441 +Y++M CW RPTF ++ L+ Sbjct: 239 EELYNIMMRCWKNRPEERPTFEYIQSVLD 267 >3A4O-X nrPDB Length = 286 Score = 225 bits (574), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 120/268 (44%), Positives = 171/268 (63%), Gaps = 9/268 (3%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQ 242 + W + + +KL++ +G G+FG+V +G Y + KVAVK +K + QAFL EA++M Sbjct: 5 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKT 64 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS-RGRSVLGGDCLLKFSLDVCEA 301 L+H LV+L V+ E+ +YI+TEYMAKGSL+D+L+S G VL L+ FS + E Sbjct: 65 LQHDKLVRLYAVVTREEP-IYIITEYMAKGSLLDFLKSDEGGKVLLPK-LIDFSAQIAEG 122 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357 M Y+E N++HRDL A NVLVSE + K++DFGL + + T K P+KWTAPEA Sbjct: 123 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 182 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 + F+ KSDVWSFGILL+EI ++G++PYP DV+ + +GY+M + CP +YD Sbjct: 183 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYD 242 Query: 418 VMKNCWHLDAATRPTFLQLREQLEHIRT 445 +MK CW A RPTF L+ L+ T Sbjct: 243 IMKMCWKEKAEERPTFDYLQSVLDDFYT 270 >4Y93-A nrPDB Length = 446 Score = 224 bits (572), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 116/253 (45%), Positives = 158/253 (62%), Gaps = 8/253 (3%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQLR 244 W ++ K+L L+ +G G+FG V G +RG VA+K IK + ++ F+ EA VM L Sbjct: 182 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 241 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H LVQL GV +++ ++I+TEYMA G L++YLR R LL+ DVCEAMEY Sbjct: 242 HEKLVQLYGVCTKQRP-IFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEY 299 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK---EASSTQDTG-KLPVKWTAPEALRE 360 LE F+HRDLAARN LV++ V KVSDFG+T+ + T TG K PVKW +PE L Sbjct: 300 LESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMY 359 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 KFS+KSD+W+FG+L+WEIYS G++PY R + + +G ++ P VY +M Sbjct: 360 SKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMY 419 Query: 421 NCWHLDAATRPTF 433 +CWH A RPTF Sbjct: 420 SCWHEKADERPTF 432 >6E4F-A nrPDB Length = 290 Score = 221 bits (563), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 113/253 (44%), Positives = 156/253 (61%), Gaps = 8/253 (3%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQLR 244 W ++ K+L L+ +G G+FG V G +RG VA+K IK + ++ F+ EA VM L Sbjct: 25 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 84 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H LVQL GV +++ ++I+TEYMA G L++YLR R LL+ DVCEAMEY Sbjct: 85 HEKLVQLYGVCTKQRP-IFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEY 142 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALRE 360 LE F+HRDLAARN LV++ V KVSDFGL++ + T K PV+W+ PE L Sbjct: 143 LESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMY 202 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 KFS+KSD+W+FG+L+WEIYS G++PY R + + +G ++ P VY +M Sbjct: 203 SKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMY 262 Query: 421 NCWHLDAATRPTF 433 +CWH A RPTF Sbjct: 263 SCWHEKADERPTF 275 >3SXS-A nrPDB Length = 268 Score = 219 bits (558), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 116/266 (43%), Positives = 162/266 (60%), Gaps = 8/266 (3%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQLRHSN 247 L +E+ LL+ +G G+FG V LG ++G VAVK IK + ++ F EA M +L H Sbjct: 5 LKREEITLLKELGSGQFGVVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPK 64 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 LV+ GV +E +YIVTEY++ G L++YLRS G+ L LL+ DVCE M +LE Sbjct: 65 LVKFYGVCSKEYP-IYIVTEYISNGCLLNYLRSHGKG-LEPSQLLEMCYDVCEGMAFLES 122 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKF 363 + F+HRDLAARN LV D KVSDFG+T+ Q K PVKW+APE K+ Sbjct: 123 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKY 182 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 S+KSDVW+FGIL+WE++S G++PY +VV +V +G+++ P +Y +M +CW Sbjct: 183 SSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSCW 242 Query: 424 HLDAATRPTFLQLREQLEHIRTHELH 449 H RPTF QL +E +R + H Sbjct: 243 HELPEKRPTFQQLLSSIEPLREKDKH 268 >5SYS-A nrPDB Length = 286 Score = 218 bits (556), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 117/267 (43%), Positives = 165/267 (61%), Gaps = 8/267 (2%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQ 242 + W + + L+L +G+G FG+ +G + G +VA+K +K + +AFL EA VM + Sbjct: 10 KDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK 69 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + + M Sbjct: 70 LRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM 127 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEAL 358 Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA Sbjct: 128 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 187 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++D+ Sbjct: 188 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDL 247 Query: 419 MKNCWHLDAATRPTFLQLREQLEHIRT 445 M CW D RPTF L+ LE T Sbjct: 248 MCQCWRKDPEERPTFEYLQAFLEDYFT 274 >2DQ7-X nrPDB Length = 283 Score = 217 bits (553), Expect = 8e-57, Method: Compositional matrix adjust. Identities = 112/264 (42%), Positives = 166/264 (62%), Gaps = 8/264 (3%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQLRH 245 W + + L+L++ +G G+FG+V +G + GN KVA+K +K + ++FL EA +M +L+H Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 63 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 LVQL V+ EE +YIVTEYM KGSL+D+L+ L L+ + V M Y+ Sbjct: 64 DKLVQLYAVVSEEP--IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 121 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREK 361 E N++HRDL + N+LV + K++DFGL + + T K P+KWTAPEA Sbjct: 122 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 181 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++++M + Sbjct: 182 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 241 Query: 422 CWHLDAATRPTFLQLREQLEHIRT 445 CW D RPTF L+ LE T Sbjct: 242 CWKKDPEERPTFEYLQSFLEDYFT 265 >5H2U-A nrPDB Length = 267 Score = 213 bits (541), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 117/263 (44%), Positives = 154/263 (58%), Gaps = 7/263 (2%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDAT--AQAFLAEASVMTQLRHSNLV 249 +E L + +G G FG+V G ++ +VA+K I D Q +E M +LRH +++ Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHIL 65 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 L V V +YI+TE MAKGSL++ LR VL LL + V E M YLE N Sbjct: 66 ALYAV-VSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 124 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLPVKWTAPEALREKKFSTK 366 ++HRDLAARN+LV E+ + KV DFGL KE +P KWTAPEAL +STK Sbjct: 125 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTK 184 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 SDVWSFGILL E++S G+VPYP + + RV+ GY+M P CPP+V+ +M CW D Sbjct: 185 SDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRD 244 Query: 427 AATRPTFLQLREQLEHIRTHELH 449 RPTF LRE+L +H H Sbjct: 245 PEQRPTFKALRERLSSFTSHHHH 267 >4XCU-A nrPDB Length = 300 Score = 213 bits (541), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 114/279 (40%), Positives = 168/279 (60%), Gaps = 24/279 (8%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRG---------NKVAVKCIKNDATAQAF---LA 235 W L L + +G+G FG V+ + G + VAVK +K++A+ + ++ Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 71 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR-----GRSVLGGD 289 E VM + RH N++ LLGV +E G LY++ E AKG+L ++LR+R L Sbjct: 72 EMEVMKLIGRHKNIINLLGVCTQE-GPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFP 130 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQD 344 L+ + V M+YLE +HRDLAARNVLV+EDNV K++DFGL + + Sbjct: 131 VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS 190 Query: 345 TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404 G+LPVKW APEAL ++ ++ +SDVWSFGILLWEI++ G PYP IP++++ + +G++ Sbjct: 191 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHR 250 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 MD P CPP +Y +M+ CWH + RPTF QL E L+ + Sbjct: 251 MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 289 >3TT0-A nrPDB Length = 382 Score = 209 bits (532), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 112/288 (38%), Positives = 169/288 (58%), Gaps = 33/288 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRG---------NKVAVKCIKNDATAQAF---LA 235 W L L L + +G+G FG V+L + G KVAVK +K+DAT + ++ Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 123 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR------------- 281 E +M + +H N++ LLG ++ G LY++ EY +KG+L +YL++R Sbjct: 124 EMEMMKMIGKHKNIINLLGACTQD-GPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSH 182 Query: 282 -GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 L L+ + V MEYL +HRDLAARNVLV+EDNV K++DFGL ++ Sbjct: 183 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 242 Query: 341 STQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 G+LPVKW APEAL ++ ++ +SDVWSFG+LLWEI++ G PYP +P++++ Sbjct: 243 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL 302 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +++G++MD P C +Y +M++CWH + RPTF QL E L+ I Sbjct: 303 FKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 350 >3GQL-A nrPDB Length = 326 Score = 209 bits (531), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 112/288 (38%), Positives = 169/288 (58%), Gaps = 33/288 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRG---------NKVAVKCIKNDATAQAF---LA 235 W L L L + +G+G FG V+L + G KVAVK +K+DAT + ++ Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 82 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR------------- 281 E +M + +H N++ LLG ++ G LY++ EY +KG+L +YL++R Sbjct: 83 EMEMMKMIGKHKNIINLLGACTQD-GPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSH 141 Query: 282 -GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 L L+ + V MEYL +HRDLAARNVLV+EDNV K++DFGL ++ Sbjct: 142 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 201 Query: 341 STQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 G+LPVKW APEAL ++ ++ +SDVWSFG+LLWEI++ G PYP +P++++ Sbjct: 202 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL 261 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +++G++MD P C +Y +M++CWH + RPTF QL E L+ I Sbjct: 262 FKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 309 >5A46-A nrPDB Length = 386 Score = 207 bits (528), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 112/288 (38%), Positives = 169/288 (58%), Gaps = 33/288 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRG---------NKVAVKCIKNDATAQAF---LA 235 W L L L + +G+G FG V+L + G KVAVK +K+DAT + ++ Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 94 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR------------- 281 E +M + +H N++ LLG ++ G LY++ EY +KG+L +YL++R Sbjct: 95 EMEMMKMIGKHKNIINLLGACTQD-GPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSH 153 Query: 282 -GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 L L+ + V MEYL +HRDLAARNVLV+EDNV K++DFGL ++ Sbjct: 154 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 213 Query: 341 STQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 G+LPVKW APEAL ++ ++ +SDVWSFG+LLWEI++ G PYP +P++++ Sbjct: 214 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL 273 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +++G++MD P C +Y +M++CWH + RPTF QL E L+ I Sbjct: 274 FKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 321 >3QGY-A nrPDB Length = 286 Score = 207 bits (528), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 113/261 (43%), Positives = 157/261 (60%), Gaps = 8/261 (3%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQA-FLAEASVMTQLRHS 246 ++ EL +Q IG G+FG V LG + +KVA+K IK + ++ F+ EA VM +L H Sbjct: 23 VIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIKEGSMSEDDFIEEAEVMMKLSHP 82 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 LVQL GV +E+ + +V E+M G L DYLR++ R + + LL LDVCE M YLE Sbjct: 83 KLVQLYGVCLEQ-APICLVFEFMEHGCLSDYLRTQ-RGLFAAETLLGMCLDVCEGMAYLE 140 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTK---EASSTQDTG-KLPVKWTAPEALREKK 362 +HRDLAARN LV E+ V KVSDFG+T+ + T TG K PVKW +PE + Sbjct: 141 EACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSR 200 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 +S+KSDVWSFG+L+WE++S G++PY +VV + G+++ P VY +M +C Sbjct: 201 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHC 260 Query: 423 WHLDAATRPTFLQLREQLEHI 443 W RP F +L QL I Sbjct: 261 WKERPEDRPAFSRLLRQLAEI 281 >4K33-A nrPDB Length = 325 Score = 206 bits (523), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 112/290 (38%), Positives = 169/290 (58%), Gaps = 33/290 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRG---------NKVAVKCIKNDATAQAF---LA 235 W L+ L L + +G+G FG V++ + G VAVK +K+DAT + ++ Sbjct: 31 WELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVS 90 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR------------- 281 E +M + +H N++ LLG + G LY++ EY AKG+L ++LR+R Sbjct: 91 EMEMMKMIGKHKNIINLLGACTQ-GGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSK 149 Query: 282 -GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 L L+ + V MEYL +HRDLAARNVLV+EDNV K++DFGL ++ Sbjct: 150 PPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVH 209 Query: 341 STQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 + G+LPVKW APEAL ++ ++ +SDVWSFG+LLWEI++ G PYP IP++++ Sbjct: 210 NLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEEL 269 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 +++G++MD P C +Y +M+ CWH + RPTF QL E L+ + T Sbjct: 270 FKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLT 319 >2PSQ-A nrPDB Length = 370 Score = 202 bits (513), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 108/290 (37%), Positives = 171/290 (58%), Gaps = 33/290 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRG---------NKVAVKCIKNDATAQAF---LA 235 W +L L + +G+G FG V++ + G VAVK +K+DAT + ++ Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 135 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR------------- 281 E +M + +H N++ LLG ++ G LY++ EY +KG+L +YLR+R Sbjct: 136 EMEMMKMIGKHKNIINLLGACTQD-GPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 194 Query: 282 -GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 + L+ + + MEYL +HRDLAARNVLV+E+NV K++DFGL ++ + Sbjct: 195 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 254 Query: 341 STQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 + G+LPVKW APEAL ++ ++ +SDVWSFG+L+WEI++ G PYP IP++++ Sbjct: 255 NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 314 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 +++G++MD P C +Y +M++CWH + RPTF QL E L+ I T Sbjct: 315 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 364 >5EG3-A nrPDB Length = 334 Score = 201 bits (510), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 109/290 (37%), Positives = 171/290 (58%), Gaps = 33/290 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK---------VAVKCIKNDATAQAF---LA 235 W +L L + +G+G FG V++ + G VAVK +K+DAT + ++ Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 89 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS--VLGGDC-- 290 E +M + +H N++ LLG ++ G LY++ Y +KG+L +YLR+R L D Sbjct: 90 EMEMMKMIGKHKNIINLLGACTQD-GPLYVIVAYASKGNLREYLRARRPPGMELSPDINR 148 Query: 291 ----------LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 L+ + + MEYL +HRDLAARNVLV+E+NV K++DFGL ++ + Sbjct: 149 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 208 Query: 341 STQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 + G+LPVKW APEAL ++ ++ +SDVWSFG+L+WEI++ G PYP IP++++ Sbjct: 209 NIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 268 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 +++G++MD P C +Y +M++CWH + RPTF QL E L+ I T Sbjct: 269 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 318 >3KUL-B nrPDB Length = 325 Score = 199 bits (505), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 113/274 (41%), Positives = 167/274 (60%), Gaps = 19/274 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCIKNDATAQA---FLAEASVMT 241 + + + + IG G+ G+V G R G + VA+K +K T + FL+EAS+M Sbjct: 46 IEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMG 105 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR-GRSVLGGDCLLKFSLDVCE 300 Q H N+++L GV+ + + IVTEYM GSL +LR+ G+ + L+ V Sbjct: 106 QFDHPNIIRLEGVVTRGRLAM-IVTEYMENGSLDTFLRTHDGQFTIMQ--LVGMLRGVGA 162 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKWTA 354 M YL +VHRDLAARNVLV + V KVSDFGL++ +A+ T GK+P++WTA Sbjct: 163 GMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTA 222 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414 PEA+ + FS+ SDVWSFG+++WE+ ++G PY + +DV+ VE+GY++ AP GCP A Sbjct: 223 PEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHA 282 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQLEH-IRTHE 447 ++ +M +CWH D A RP F Q+ L+ IR+ E Sbjct: 283 LHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPE 316 >4P5Q-A nrPDB Length = 361 Score = 196 bits (498), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 109/286 (38%), Positives = 167/286 (58%), Gaps = 19/286 (6%) Query: 172 VMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG-----DYRGNKVAVKCIKN 226 V G+ EF + L+ + + + +G GEFG+V G + VA+K +K Sbjct: 15 VPRGSTQTVHEFAKE---LDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKV 71 Query: 227 DATAQA---FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR 283 T + FL EAS+M Q H N+++L GV+ + K + IVTEYM GSL +LR + Sbjct: 72 GYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKP-VMIVTEYMENGSLDSFLR-KHD 129 Query: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------ 337 + L+ + M+YL +VHRDLAARN+L++ + V KVSDFGL++ Sbjct: 130 AQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDP 189 Query: 338 EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVP 397 EA+ T GK+P++WT+PEA+ +KF++ SDVWS+GI+LWE+ S+G PY + +DV+ Sbjct: 190 EAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIK 249 Query: 398 RVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 V++GY++ P CP A+Y +M +CW D RP F Q+ L+ + Sbjct: 250 AVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKL 295 >4EBW-A nrPDB Length = 304 Score = 195 bits (496), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 103/272 (37%), Positives = 156/272 (57%), Gaps = 15/272 (5%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK-----VAVKCIKN---DATAQAFLAEASV 239 + + + ++L + IG+G+FGDV G Y + VA+K KN D+ + FL EA Sbjct: 33 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT 92 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 M Q H ++V+L+GVI E ++I+ E G L +L+ R S L L+ ++ + Sbjct: 93 MRQFDHPHIVKLIGVITENP--VWIIMELCTLGELRSFLQVRKYS-LDLASLILYAYQLS 149 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAP 355 A+ YLE FVHRD+AARNVLVS ++ K+ DFGL++ + GKLP+KW AP Sbjct: 150 TALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAP 209 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ ++F++ SDVW FG+ +WEI G P+ + DV+ R+E G ++ P CPP + Sbjct: 210 ESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTL 269 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 Y +M CW D + RP F +L+ QL I E Sbjct: 270 YSLMTKCWAYDPSRRPRFTELKAQLSTILEEE 301 >4PDO-A nrPDB Length = 299 Score = 194 bits (494), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 107/262 (40%), Positives = 158/262 (60%), Gaps = 21/262 (8%) Query: 199 QTIGKGEFGDV---MLGDYRGNK---VAVKCIKNDATAQA---FLAEASVMTQLRHSNLV 249 + IG GEFG+V ML G K VA+K +K T + FL EA +M Q H N++ Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNII 99 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVCEAMEYLEG 307 +L GVI + K + I+TEYM G+L +LR + SVL +L+ + M+YL Sbjct: 100 RLEGVISKYKP-MMIITEYMENGALDKFLREKDGEFSVLQLVGMLR---GIAAGMKYLAN 155 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKWTAPEALREK 361 N+VHRDLAARN+LV+ + V KVSDFGL++ EA+ T GK+P++WTAPEA+ + Sbjct: 156 MNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYR 215 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 KF++ SDVWSFGI++WE+ ++G PY + +V+ + G+++ P CP A+Y +M Sbjct: 216 KFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQ 275 Query: 422 CWHLDAATRPTFLQLREQLEHI 443 CW + A RP F + L+ + Sbjct: 276 CWQQERARRPKFADIVSILDKL 297 >2Y6O-A nrPDB Length = 291 Score = 194 bits (493), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 106/264 (40%), Positives = 165/264 (62%), Gaps = 18/264 (6%) Query: 195 LKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCIK---NDATAQAFLAEASVMTQLRHS 246 +K+ + IG GEFG+V G + G + VA+K +K D + FL+EAS+M Q H Sbjct: 16 IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP 75 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR-GRSVLGGDCLLKFSLDVCEAMEYL 305 N++ L GV+ + K + I+TEYM GSL +LR GR + L+ + M+YL Sbjct: 76 NIIHLEGVVTKCKP-VMIITEYMENGSLDAFLRKNDGRFTVIQ--LVGMLRGIGSGMKYL 132 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKWTAPEALR 359 ++VHRDLAARN+LV+ + V KVSDFG+++ EA+ T GK+P++WTAPEA+ Sbjct: 133 SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 192 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 +KF++ SDVWS+GI++WE+ S+G PY + +DV+ +E+GY++ P CP A++ +M Sbjct: 193 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLM 252 Query: 420 KNCWHLDAATRPTFLQLREQLEHI 443 +CW + + RP F Q+ L+ + Sbjct: 253 LDCWQKERSDRPKFGQIVNMLDKL 276 >2J0K-A nrPDB Length = 656 Score = 193 bits (491), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 103/272 (37%), Positives = 155/272 (56%), Gaps = 15/272 (5%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK-----VAVKCIKN---DATAQAFLAEASV 239 + + + ++L + IG+G+FGDV G Y + VA+K KN D+ + FL EA Sbjct: 385 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALT 444 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 M Q H ++V+L+GVI E ++I+ E G L +L+ R S L L+ ++ + Sbjct: 445 MRQFDHPHIVKLIGVITE--NPVWIIMELCTLGELRSFLQVRKFS-LDLASLILYAYQLS 501 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAP 355 A+ YLE FVHRD+AARNVLVS + K+ DFGL++ + GKLP+KW AP Sbjct: 502 TALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAP 561 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ ++F++ SDVW FG+ +WEI G P+ + DV+ R+E G ++ P CPP + Sbjct: 562 ESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTL 621 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 Y +M CW D + RP F +L+ QL I E Sbjct: 622 YSLMTKCWAYDPSRRPRFTELKAQLSTILEEE 653 >2R2P-A nrPDB Length = 295 Score = 192 bits (488), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 104/263 (39%), Positives = 159/263 (60%), Gaps = 16/263 (6%) Query: 195 LKLLQTIGKGEFGDVMLGDY-----RGNKVAVKCIKNDATAQA---FLAEASVMTQLRHS 246 + + + IG GEFG+V G R VA+K +K T + FL EAS+M Q H Sbjct: 24 ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP 83 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N++ L GV+ + K + IVTEYM GSL +L+ + L+ + M+YL Sbjct: 84 NIIHLEGVVTKSKP-VMIVTEYMENGSLDTFLK-KNDGQFTVIQLVGMLRGISAGMKYLS 141 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKWTAPEALRE 360 +VHRDLAARN+L++ + V KVSDFGL++ EA+ T GK+P++WTAPEA+ Sbjct: 142 DMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAF 201 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 +KF++ SDVWS+GI++WE+ S+G PY + +DV+ VE+GY++ +P CP A+Y +M Sbjct: 202 RKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLML 261 Query: 421 NCWHLDAATRPTFLQLREQLEHI 443 +CW + +RP F ++ L+ + Sbjct: 262 DCWQKERNSRPKFDEIVNMLDKL 284 >3DKO-A nrPDB Length = 318 Score = 192 bits (488), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 117/310 (37%), Positives = 170/310 (54%), Gaps = 30/310 (9%) Query: 141 DEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQT 200 DEE+YF + Y I P+ E A +F + L+ +K+ + Sbjct: 5 DEELYFHFKFPGTKTY-----------IDPETYEDPNRAVHQFAKE---LDASCIKIERV 50 Query: 201 IGKGEFGDVMLGDY-----RGNKVAVKCIKNDATAQA---FLAEASVMTQLRHSNLVQLL 252 IG GEFG+V G R VA+K +K T + FL EAS+M Q H N+V L Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 110 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 GV+ K + IV E+M G+L +LR L+ + M YL +VH Sbjct: 111 GVVTRGKP-VMIVIEFMENGALDAFLRKHDGQFTVIQ-LVGMLRGIAAGMRYLADMGYVH 168 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKWTAPEALREKKFSTK 366 RDLAARN+LV+ + V KVSDFGL++ EA T GK+PV+WTAPEA++ +KF++ Sbjct: 169 RDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSA 228 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 SDVWS+GI++WE+ S+G PY + +DV+ +E+GY++ AP CP ++ +M +CW + Sbjct: 229 SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKE 288 Query: 427 AATRPTFLQL 436 A RP F Q+ Sbjct: 289 RAERPKFEQI 298 >1JPA-A nrPDB Length = 312 Score = 192 bits (487), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 111/295 (37%), Positives = 175/295 (59%), Gaps = 25/295 (8%) Query: 167 LIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAV 221 I P E A EF + +++ +K+ Q IG GEFG+V G + G + VA+ Sbjct: 10 FIDPFTFEDPNEAVREFAKE---IDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAI 66 Query: 222 KCIKNDATAQA---FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL 278 K +K+ T + FL+EAS+M Q H N++ L GV+ + + I+TE+M GSL +L Sbjct: 67 KTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTP-VMIITEFMENGSLDSFL 125 Query: 279 RSRGR--SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT 336 R +V+ +L+ + M+YL N+VHRDLAARN+LV+ + V KVSDFGL+ Sbjct: 126 RQNDGQFTVIQLVGMLR---GIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLS 182 Query: 337 K--EASSTQDT------GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 + E ++ T GK+P++WTAPEA++ +KF++ SDVWS+GI++WE+ S+G PY Sbjct: 183 RFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYW 242 Query: 389 RIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + +DV+ +E+ Y++ P CP A++ +M +CW D RP F Q+ L+ + Sbjct: 243 DMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 297 >4H1J-A nrPDB Length = 293 Score = 189 bits (481), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 103/272 (37%), Positives = 158/272 (58%), Gaps = 15/272 (5%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK-----VAVKCIKNDAT---AQAFLAEASV 239 + + +++ L + +G+G FG+V G Y +K VAVK K D T + F++EA + Sbjct: 19 YGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVI 78 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 M L H ++V+L+G+I EE +I+ E G L YL R ++ L L+ +SL +C Sbjct: 79 MKNLDHPHIVKLIGIIEEEPT--WIIMELYPYGELGHYLE-RNKNSLKVLTLVLYSLQIC 135 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVKWTAP 355 +AM YLE N VHRD+A RN+LV+ K+ DFGL++ E +LP+KW +P Sbjct: 136 KAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSP 195 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ ++F+T SDVW F + +WEI SFG+ P+ + KDV+ +EKG ++ PD CPP + Sbjct: 196 ESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVL 255 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 Y +M CW D + RP F +L L + E Sbjct: 256 YTLMTRCWDYDPSDRPRFTELVCSLSDVYQME 287 >3PLS-A nrPDB Length = 298 Score = 189 bits (479), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 106/260 (40%), Positives = 151/260 (58%), Gaps = 16/260 (6%) Query: 199 QTIGKGEFGDVMLGDY---RGNKV--AVKCIKNDATAQ---AFLAEASVMTQLRHSNLVQ 250 + IGKG FG V G+Y N++ A+K + Q AFL E +M L H N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 L+G+++ +G +++ YM G L+ ++RS R+ D L+ F L V MEYL F Sbjct: 87 LIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKD-LISFGLQVARGMEYLAEQKF 145 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDT--GKLPVKWTAPEALREKKF 363 VHRDLAARN ++ E KV+DFGL + E S Q +LPVKWTA E+L+ +F Sbjct: 146 VHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYRF 205 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 +TKSDVWSFG+LLWE+ + G PY I D+ + +G ++ P+ CP ++Y VM+ CW Sbjct: 206 TTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCW 265 Query: 424 HLDAATRPTFLQLREQLEHI 443 D A RPTF L ++E I Sbjct: 266 EADPAVRPTFRVLVGEVEQI 285 >3CJF-A nrPDB Length = 309 Score = 187 bits (476), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 104/285 (36%), Positives = 159/285 (55%), Gaps = 27/285 (9%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATA---QAFLA 235 S W L L + +G+G FG V+ D G VAVK +K AT +A ++ Sbjct: 20 SKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMS 79 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG----------RS 284 E ++ + H N+V LLG + G L ++ E+ G+L YLRS+ + Sbjct: 80 ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKD 139 Query: 285 VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD 344 L + L+ +S V + ME+L +HRDLAARN+L+SE NV K+ DFGL ++ D Sbjct: 140 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 199 Query: 345 -----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL-KDVVPR 398 +LP+KW APE + ++ ++ +SDVWSFG+LLWEI+S G PYP + + ++ R Sbjct: 200 YVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRR 259 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +++G +M APD P +Y M +CWH + + RPTF +L E L ++ Sbjct: 260 LKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNL 304 >5X02-A nrPDB Length = 347 Score = 185 bits (470), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 111/291 (38%), Positives = 157/291 (53%), Gaps = 39/291 (13%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATA---QAF 233 Y W + L+ + +G G FG VM G +VAVK +K A + +A Sbjct: 39 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 98 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR--------- 283 ++E +MTQL H N+V LLG G +Y++ EY G L++YLRS+ Sbjct: 99 MSELKMMTQLGSHENIVNLLGACTL-SGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEY 157 Query: 284 ------------SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVS 331 +VL + LL F+ V + ME+LE + VHRDLAARNVLV+ V K+ Sbjct: 158 ENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKIC 217 Query: 332 DFGLTKEASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP 386 DFGL ++ S + +LPVKW APE+L E ++ KSDVWS+GILLWEI+S G P Sbjct: 218 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP 277 Query: 387 YPRIPLK-DVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 YP IP+ + ++ G+KMD P +Y +M++CW D+ RP+F L Sbjct: 278 YPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >5MJB-A nrPDB Length = 305 Score = 185 bits (469), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 102/272 (37%), Positives = 167/272 (61%), Gaps = 22/272 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCIK---NDATAQAFLAEASVMT 241 +++ +K+ + IG GEFG+V G + G + VA+K +K ++ + FL+EAS+M Sbjct: 23 IDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMG 82 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVC 299 Q H N+++L GV+ + + + I+TE+M +L +LR +V+ +L+ + Sbjct: 83 QFDHRNIIRLEGVVTKSRP-VMIITEFMENCALDSFLRQNDGQFTVIQLVGMLR---GIA 138 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE-ASSTQDT-------GKLPVK 351 M+YL N+VHRDLAARN+LV+ + V KVSDFGL++ T D GK+PV+ Sbjct: 139 AGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVR 198 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC 411 WTAPEA+ +KF++ SDVWS+GI++WE+ SFG PY + +DV+ +E+ Y++ P C Sbjct: 199 WTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDC 258 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 P A++ +M +CW D +RP F ++ L+ + Sbjct: 259 PAALHQLMLDCWQKDRNSRPRFAEIVNTLDKM 290 >2VWV-A nrPDB Length = 302 Score = 185 bits (469), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 104/272 (38%), Positives = 168/272 (61%), Gaps = 22/272 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCIKNDATAQA---FLAEASVMT 241 +++ +K+ + IG GEFG+V G + G K VA+K +K T + FL+EAS+M Sbjct: 13 IDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMG 72 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRGR-SVLGGDCLLKFSLDVC 299 Q H N+++L GV+ + I+TE+M G+L +LR + G+ +V+ +L+ + Sbjct: 73 QFEHPNIIRLEGVVTNSMP-VMILTEFMENGALDSFLRLNDGQFTVIQLVGMLR---GIA 128 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDT------GKLPVK 351 M YL ++VHRDLAARN+LV+ + V KVSDFGL++ E +S+ T GK+P++ Sbjct: 129 SGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIR 188 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC 411 WTAPEA+ +KF++ SD WS+GI++WE+ SFG PY + +DV+ +E+ Y++ P C Sbjct: 189 WTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDC 248 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 P +++ +M +CW D RP F Q+ L+ + Sbjct: 249 PTSLHQLMLDCWQKDRNARPRFPQVVSALDKM 280 >4XUF-A nrPDB Length = 297 Score = 185 bits (469), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 110/287 (38%), Positives = 156/287 (54%), Gaps = 39/287 (13%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATA---QAFLAEA 237 W + L+ + +G G FG VM G +VAVK +K A + +A ++E Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 63 Query: 238 SVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR------------- 283 +MTQL H N+V LLG G +Y++ EY G L++YLRS+ Sbjct: 64 KMMTQLGSHENIVNLLGACTL-SGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQK 122 Query: 284 --------SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL 335 +VL + LL F+ V + ME+LE + VHRDLAARNVLV+ V K+ DFGL Sbjct: 123 RLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGL 182 Query: 336 TKEASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI 390 ++ S + +LPVKW APE+L E ++ KSDVWS+GILLWEI+S G PYP I Sbjct: 183 ARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI 242 Query: 391 PLK-DVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 P+ + ++ G+KMD P +Y +M++CW D+ RP+F L Sbjct: 243 PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >4XLV-A nrPDB Length = 328 Score = 184 bits (467), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 107/288 (37%), Positives = 158/288 (54%), Gaps = 29/288 (10%) Query: 172 VMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCI 224 V +V DE W ++ +++ LL+ +G+G FG V G+ R +VAVK + Sbjct: 23 VFPSSVYVPDE-----WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTV 77 Query: 225 KNDATAQA---FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS- 280 A+ + FL EASVM ++V+LLGV+ + + L +V E MA G L YLRS Sbjct: 78 NESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTL-VVMELMAHGDLKSYLRSL 136 Query: 281 -------RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDF 333 GR +++ + ++ + M YL FVHRDLAARN +V+ D K+ DF Sbjct: 137 RPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF 196 Query: 334 GLTKEASSTQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 G+T++ T G LPV+W APE+L++ F+T SD+WSFG++LWEI S PY Sbjct: 197 GMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQ 256 Query: 389 RIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 + + V+ V G +D PD CP V D+M+ CW + RPTFL++ Sbjct: 257 GLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEI 304 >5HLW-A nrPDB Length = 299 Score = 184 bits (467), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 103/260 (39%), Positives = 147/260 (56%), Gaps = 16/260 (6%) Query: 199 QTIGKGEFGDVMLG---DYRGNKV--AVKC---IKNDATAQAFLAEASVMTQLRHSNLVQ 250 + IG+G FG V G D G K+ AVK I + FL E +M H N++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 85 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 LLG+ + +G +V YM G L +++R+ + D L+ F L V + M+YL F Sbjct: 86 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKD-LIGFGLQVAKGMKYLASKKF 144 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEA------SSTQDTG-KLPVKWTAPEALREKKF 363 VHRDLAARN ++ E KV+DFGL ++ S TG KLPVKW A E+L+ +KF Sbjct: 145 VHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQKF 204 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 +TKSDVWSFG+LLWE+ + G PYP + D+ + +G ++ P+ CP +Y+VM CW Sbjct: 205 TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW 264 Query: 424 HLDAATRPTFLQLREQLEHI 443 H A RP+F +L ++ I Sbjct: 265 HPKAEMRPSFSELVSRISAI 284 >3BEA-A nrPDB Length = 333 Score = 184 bits (467), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 109/294 (37%), Positives = 160/294 (54%), Gaps = 34/294 (11%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATA---QAF 233 Y W L+ +T+G G FG V+ G KVAVK +K+ A A +A Sbjct: 37 YNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL 96 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR--------- 283 ++E +M+ L +H N+V LLG G + ++TEY G L+++LR + R Sbjct: 97 MSELKIMSHLGQHENIVNLLGACTH-GGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFA 155 Query: 284 ---SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 S L LL FS V + M +L N +HRD+AARNVL++ +VAK+ DFGL ++ Sbjct: 156 IANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIM 215 Query: 341 STQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 + + +LPVKW APE++ + ++ +SDVWS+GILLWEI+S G PYP I + Sbjct: 216 NDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSK 275 Query: 396 VPR-VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQ----LREQLEHIR 444 + V+ GY+M P P +Y +M+ CW L+ RPTF Q L+EQ + R Sbjct: 276 FYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDR 329 >3I81-A nrPDB Length = 315 Score = 183 bits (464), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 102/292 (34%), Positives = 166/292 (56%), Gaps = 28/292 (9%) Query: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDAT 229 V+A D + W + +++ + + +G+G FG V G +G +VA+K + A+ Sbjct: 2 VSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAAS 61 Query: 230 AQA---FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS-----R 281 + FL EASVM + ++V+LLGV+ + + L ++ E M +G L YLRS Sbjct: 62 MRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTL-VIMELMTRGDLKSYLRSLRPEME 120 Query: 282 GRSVLGGDCL---LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 VL L ++ + ++ + M YL N FVHRDLAARN +V+ED K+ DFG+T++ Sbjct: 121 NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRD 180 Query: 339 ASSTQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK 393 T G LPV+W +PE+L++ F+T SDVWSFG++LWEI + PY + + Sbjct: 181 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE 240 Query: 394 DVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQ----LREQLE 441 V+ V +G +D PD CP ++++M+ CW + RP+FL+ ++E++E Sbjct: 241 QVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME 292 >1FVR-A nrPDB Length = 327 Score = 183 bits (464), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 104/285 (36%), Positives = 157/285 (55%), Gaps = 29/285 (10%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKV----AVKCIKNDATA---QAFLAEASVMTQ 242 L+ ++K IG+G FG V+ + + + A+K +K A+ + F E V+ + Sbjct: 22 LDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCK 81 Query: 243 L-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR--------------SRGRSVLG 287 L H N++ LLG E +G LY+ EY G+L+D+LR + S L Sbjct: 82 LGHHPNIINLLGA-CEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLS 140 Query: 288 GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDT 345 LL F+ DV M+YL F+HRDLAARN+LV E+ VAK++DFGL++ E + Sbjct: 141 SQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTM 200 Query: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM 405 G+LPV+W A E+L ++T SDVWS+G+LLWEI S G PY + ++ ++ +GY++ Sbjct: 201 GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRL 260 Query: 406 DAPDGCPPAVYDVMKNCWHLDAATRPTFLQ----LREQLEHIRTH 446 + P C VYD+M+ CW RP+F Q L LE +T+ Sbjct: 261 EKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTY 305 >3C1X-A nrPDB Length = 373 Score = 182 bits (462), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 102/260 (39%), Positives = 147/260 (56%), Gaps = 16/260 (6%) Query: 199 QTIGKGEFGDVMLG---DYRGNKV--AVKC---IKNDATAQAFLAEASVMTQLRHSNLVQ 250 + IG+G FG V G D G K+ AVK I + FL E +M H N++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 154 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 LLG+ + +G +V YM G L +++R+ + D L+ F L V + M++L F Sbjct: 155 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKD-LIGFGLQVAKGMKFLASKKF 213 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEA------SSTQDTG-KLPVKWTAPEALREKKF 363 VHRDLAARN ++ E KV+DFGL ++ S TG KLPVKW A E+L+ +KF Sbjct: 214 VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKF 273 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 +TKSDVWSFG+LLWE+ + G PYP + D+ + +G ++ P+ CP +Y+VM CW Sbjct: 274 TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW 333 Query: 424 HLDAATRPTFLQLREQLEHI 443 H A RP+F +L ++ I Sbjct: 334 HPKAEMRPSFSELVSRISAI 353 >4R7H-A nrPDB Length = 343 Score = 182 bits (462), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 108/303 (35%), Positives = 161/303 (53%), Gaps = 43/303 (14%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATA---QAF 233 Y W L+ +T+G G FG V+ G KVAVK +K+ A A +A Sbjct: 41 YNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL 100 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC-- 290 ++E +M+ L +H N+V LLG G + ++TEY G L+++LR + ++LG Sbjct: 101 MSELKIMSHLGQHENIVNLLGACTH-GGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSP 159 Query: 291 -------------------LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVS 331 LL FS V + M +L N +HRD+AARNVL++ +VAK+ Sbjct: 160 GQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIG 219 Query: 332 DFGLTKEASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP 386 DFGL ++ + + +LPVKW APE++ + ++ +SDVWS+GILLWEI+S G P Sbjct: 220 DFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNP 279 Query: 387 YPRIPLKDVVPR-VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQ----LREQLE 441 YP I + + V+ GY+M P P +Y +M+ CW L+ RPTF Q L+EQ + Sbjct: 280 YPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQITSFLQEQAQ 339 Query: 442 HIR 444 R Sbjct: 340 EDR 342 >2OGV-A nrPDB Length = 317 Score = 181 bits (460), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 107/290 (36%), Positives = 160/290 (55%), Gaps = 30/290 (10%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATA---QAF 233 Y W L+ +T+G G FG V+ G KVAVK +K+ A A +A Sbjct: 29 YNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL 88 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC-- 290 ++E +M+ L +H N+V LLG G + ++TEY G L+++LR + + L + Sbjct: 89 MSELKIMSHLGQHENIVNLLGACTH-GGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGR 147 Query: 291 ------LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD 344 LL FS V + M +L N +HRD+AARNVL++ +VAK+ DFGL ++ + + Sbjct: 148 PLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSN 207 Query: 345 -----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR- 398 +LPVKW APE++ + ++ +SDVWS+GILLWEI+S G PYP I + + Sbjct: 208 YIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKL 267 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQ----LREQLEHIR 444 V+ GY+M P P +Y +M+ CW L+ RPTF Q L+EQ + R Sbjct: 268 VKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDR 317 >6GQK-A nrPDB Length = 328 Score = 181 bits (459), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 99/289 (34%), Positives = 155/289 (53%), Gaps = 32/289 (11%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATA---QAF 233 Y W L +T+G G FG V+ +G VAVK +K A + +A Sbjct: 32 YDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREAL 91 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG---------- 282 ++E V++ L H N+V LLG G ++TEY G L+++LR + Sbjct: 92 MSELKVLSYLGNHENIVNLLGACTH-GGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAP 150 Query: 283 ----RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 + L + LL FS V + M +L N +HRDLAARN+L++ N+ K+ DFGL ++ Sbjct: 151 EDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARD 210 Query: 339 ASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK 393 + + +LPVKW APE++ ++ +SDVWS+GI LWE++S G PYP +P+ Sbjct: 211 IKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVD 270 Query: 394 DVVPR-VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 + +++G++M +P+ P +YD+MK CW D RPTF Q+ + +E Sbjct: 271 SKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIE 319 >5GRN-A nrPDB Length = 356 Score = 181 bits (458), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 111/301 (36%), Positives = 160/301 (53%), Gaps = 42/301 (13%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATA---QAF 233 Y S W L L + +G G FG V+ G G KVAVK +K A + QA Sbjct: 37 YDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQAL 96 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR------------- 279 ++E +MT L H N+V LLG + G +YI+TEY G LV+YL Sbjct: 97 MSELKIMTHLGPHLNIVNLLGACTKS-GPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKS 155 Query: 280 ---SRGRSVLGGDC--------LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA 328 S +++L D LL F+ V ME+L N VHRDLAARNVL+++ + Sbjct: 156 MLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIV 215 Query: 329 KVSDFGLTKEASS-----TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFG 383 K+ DFGL ++ ++ + LPVKW APE++ + ++T SDVWS+GILLWEI+S G Sbjct: 216 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG 275 Query: 384 RVPYPRIPLKDVV-PRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 PYP + + +++ GY+M PD VY++M CW+ + RP+F L E +E+ Sbjct: 276 GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 335 Query: 443 I 443 + Sbjct: 336 L 336 >5U6C-A nrPDB Length = 315 Score = 181 bits (458), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 105/271 (38%), Positives = 157/271 (57%), Gaps = 22/271 (8%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGN-----KVAVKCIKNDATAQ----AFLAEASVMTQLRH 245 L L + +G+GEFG VM G+ + KVAVK +K D ++Q FL+EA+ M H Sbjct: 38 LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSH 97 Query: 246 SNLVQLLGVIVE-EKGGL---YIVTEYMAKGSLVDYL-RSR---GRSVLGGDCLLKFSLD 297 N+++LLGV +E G+ ++ +M G L YL SR G + LLKF +D Sbjct: 98 PNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVD 157 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-----DTGKLPVKW 352 + MEYL NF+HRDLAARN ++ +D V+DFGL+K+ S K+PVKW Sbjct: 158 IALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW 217 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 A E+L ++ +++KSDVW+FG+ +WEI + G PYP + ++ + G+++ P+ C Sbjct: 218 IAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL 277 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +Y++M +CW D RPTF LR QLE + Sbjct: 278 DELYEIMYSCWRTDPLDRPTFSVLRLQLEKL 308 >5L6P-A nrPDB Length = 298 Score = 181 bits (458), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 103/271 (38%), Positives = 166/271 (61%), Gaps = 20/271 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCIKNDATAQA---FLAEASVMT 241 +++ +K+ + IG GEFG+V G + G + VA+K +K T + FL+EAS+M Sbjct: 16 IDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMG 75 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRGRSVLGGDCLLKFSLDVCE 300 Q H N+++L GV+ + + + I+TE+M +L +LR + G+ + L+ + Sbjct: 76 QFDHPNIIRLEGVVTKSRP-VMILTEFMENCALDSFLRLNDGQFTVIQ--LVGMLRGIAA 132 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDT------GKLPVKW 352 M+YL N+VHRDLAARN+LV+ + V KVSDFGL++ E + T GK+P++W Sbjct: 133 GMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW 192 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 TAPEA+ +KF++ SDVWS+GI++WE+ S+G PY + +DV+ VE+ Y++ P CP Sbjct: 193 TAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCP 252 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 A++ +M +CW D RP F Q+ L+ + Sbjct: 253 TALHQLMLDCWVRDRNLRPKFSQIVNTLDKL 283 >4HZS-A nrPDB Length = 341 Score = 181 bits (458), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 99/266 (37%), Positives = 156/266 (58%), Gaps = 22/266 (8%) Query: 193 KELKLLQTIGKGEFGDVMLGDY-----RGNKVAVKCIKNDATAQA-----FLAEASVMTQ 242 K+L+LL+ +G G FG V G++ + VAVKC+K D +Q F+ E + M Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS-RGRSVLGGDCLLKFSLDVCEA 301 L H NL++L GV++ + +VTE GSL+D LR +G +LG L ++++ V E Sbjct: 72 LDHRNLIRLYGVVLTPP--MKMVTELAPLGSLLDRLRKHQGHFLLG--TLSRYAVQVAEG 127 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST------QDTGKLPVKWTAP 355 M YLE F+HRDLAARN+L++ ++ K+ DFGL + Q+ K+P W AP Sbjct: 128 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 187 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-GYKMDAPDGCPPA 414 E+L+ + FS SD W FG+ LWE++++G+ P+ + ++ +++K G ++ P+ CP Sbjct: 188 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 247 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQL 440 +Y+VM CW RPTF+ LR+ L Sbjct: 248 IYNVMVQCWAHKPEDRPTFVALRDFL 273 >1U54-B nrPDB Length = 291 Score = 180 bits (457), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 99/266 (37%), Positives = 156/266 (58%), Gaps = 22/266 (8%) Query: 193 KELKLLQTIGKGEFGDVMLGDY-----RGNKVAVKCIKNDATAQA-----FLAEASVMTQ 242 K+L+LL+ +G G FG V G++ + VAVKC+K D +Q F+ E + M Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS-RGRSVLGGDCLLKFSLDVCEA 301 L H NL++L GV++ + +VTE GSL+D LR +G +LG L ++++ V E Sbjct: 78 LDHRNLIRLYGVVLTPP--MKMVTELAPLGSLLDRLRKHQGHFLLG--TLSRYAVQVAEG 133 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST------QDTGKLPVKWTAP 355 M YLE F+HRDLAARN+L++ ++ K+ DFGL + Q+ K+P W AP Sbjct: 134 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 193 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-GYKMDAPDGCPPA 414 E+L+ + FS SD W FG+ LWE++++G+ P+ + ++ +++K G ++ P+ CP Sbjct: 194 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 253 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQL 440 +Y+VM CW RPTF+ LR+ L Sbjct: 254 IYNVMVQCWAHKPEDRPTFVALRDFL 279 >5AMN-A nrPDB Length = 299 Score = 179 bits (453), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 103/280 (36%), Positives = 160/280 (57%), Gaps = 26/280 (9%) Query: 188 WALNMKELKLLQTIGKGEFGDV-------MLGDYRGNKVAVKCIKNDATA---QAFLAEA 237 W K L L +T+G+GEFG V + G VAVK +K +A+ + L+E Sbjct: 18 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 77 Query: 238 SVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRG--------RSVLGG 288 +V+ Q+ H ++++L G ++ G L ++ EY GSL +LR SR R++ G Sbjct: 78 NVLKQVNHPHVIKLYGACSQD-GPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMG 136 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-----TQ 343 D L+ F+ + + M+YL VHRDLAARN+LV+E K+SDFGL+++ + Sbjct: 137 D-LISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR 195 Query: 344 DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY 403 G++PVKW A E+L + ++T+SDVWSFG+LLWEI + G PYP IP + + ++ G+ Sbjct: 196 SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGH 255 Query: 404 KMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +M+ PD C +Y +M CW + RP F + + LE + Sbjct: 256 RMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM 295 >3KRL-A nrPDB Length = 335 Score = 178 bits (451), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 107/296 (36%), Positives = 158/296 (53%), Gaps = 36/296 (12%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATA---QAF 233 Y W L+ +T+G G FG V+ G KVAVK +K+ A A +A Sbjct: 37 YNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL 96 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR----------- 281 ++E +M+ L +H N+V LLG G + ++TEY G L+++LR + Sbjct: 97 MSELKIMSHLGQHENIVNLLGACTH-GGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNP 155 Query: 282 ---GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 L LL FS V + M +L N +HRD+AARNVL++ +VAK+ DFGL ++ Sbjct: 156 SHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARD 215 Query: 339 ASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK 393 + + +LPVKW APE++ + ++ +SDVWS+GILLWEI+S G PYP I + Sbjct: 216 IMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVN 275 Query: 394 DVVPR-VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQ----LREQLEHIR 444 + V+ GY+M P P +Y +M+ CW L+ RPTF Q L+EQ + R Sbjct: 276 SKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDR 331 >3BBT-B nrPDB Length = 328 Score = 176 bits (445), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 98/268 (36%), Positives = 148/268 (55%), Gaps = 17/268 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGN------KVAVKCIKNDATAQA---FLAEASVM 240 L ELK ++ +G G FG V G + VA+K + +A F+ EA +M Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 71 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + H +LV+LLGV + + +VT+ M G L++Y+ ++ G LL + + + + Sbjct: 72 ASMDHPHLVRLLGVCLSPT--IQLVTQLMPHGCLLEYVHEHKDNI-GSQLLLNWCVQIAK 128 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAP 355 M YLE VHRDLAARNVLV N K++DFGL + E D GK+P+KW A Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMAL 188 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E + +KF+ +SDVWS+G+ +WE+ +FG PY IP +++ +EKG ++ P C V Sbjct: 189 ECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDV 248 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHI 443 Y VM CW +DA +RP F +L + + Sbjct: 249 YMVMVKCWMIDADSRPKFKELAAEFSRM 276 >3AOX-A nrPDB Length = 344 Score = 175 bits (443), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 104/273 (38%), Positives = 153/273 (56%), Gaps = 24/273 (8%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATAQA---FLAEASVMTQ 242 K + L++ +G G FG+V G G +VAVK + + Q FL EA ++++ Sbjct: 47 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 106 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRGR----SVLGGDCLLKFSLD 297 H N+V+ +GV ++ +I+ E MA G L +LR +R R S L LL + D Sbjct: 107 FNHQNIVRCIGVSLQSLP-RFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARD 165 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKE---ASSTQDTG--KLP 349 + +YLE N+F+HRD+AARN L++ VAK+ DFG+ ++ AS + G LP Sbjct: 166 IACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLP 225 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD 409 VKW PEA E F++K+D WSFG+LLWEI+S G +PYP ++V+ V G +MD P Sbjct: 226 VKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPK 285 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 CP VY +M CW RP F + E++E+ Sbjct: 286 NCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY 318 >5C26-A nrPDB Length = 299 Score = 174 bits (441), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 107/258 (41%), Positives = 149/258 (57%), Gaps = 18/258 (6%) Query: 199 QTIGKGEFGDVMLGDYR----GNKVAVKCIKNDATAQAF----LAEASVMTQLRHSNLVQ 250 + +G G FG V G Y+ VAVK +KN+A A LAEA+VM QL + +V+ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 ++G+ E +V E G L YL+ + R V + +++ V M+YLE +NF Sbjct: 93 MIGIC--EAESWMLVMEMAELGPLNKYLQ-QNRHVKDKN-IIELVHQVSMGMKYLEESNF 148 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASS------TQDTGKLPVKWTAPEALREKKFS 364 VHRDLAARNVL+ + AK+SDFGL+K + Q GK PVKW APE + KFS Sbjct: 149 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 208 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWH 424 +KSDVWSFG+L+WE +S+G+ PY + +V +EKG +M P GCP +YD+M CW Sbjct: 209 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 268 Query: 425 LDAATRPTFLQLREQLEH 442 D RP F + +L + Sbjct: 269 YDVENRPGFAAVELRLRN 286 >4FL3-A nrPDB Length = 635 Score = 174 bits (441), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 115/287 (40%), Positives = 160/287 (55%), Gaps = 19/287 (6%) Query: 171 KVMEGTVAAQDEFYRSGWALNMKELKLL-QTIGKGEFGDVMLGDYR----GNKVAVKCIK 225 +V E A +E L+ K L L + +G G FG V G Y+ VAVK +K Sbjct: 346 EVFESPFADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK 405 Query: 226 NDATAQAF----LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR 281 N+A A LAEA+VM QL + +V+++G+ E +V E G L YL+ + Sbjct: 406 NEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES--WMLVMEMAELGPLNKYLQ-Q 462 Query: 282 GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS 341 R V + +++ V M+YLE +NFVHRDLAARNVL+ + AK+SDFGL+K + Sbjct: 463 NRHVKDKN-IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 Query: 342 ------TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 Q GK PVKW APE + KFS+KSDVWSFG+L+WE +S+G+ PY + +V Sbjct: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 +EKG +M P GCP +YD+M CW D RP F + +L + Sbjct: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 53/111 (47%), Positives = 64/111 (57%), Gaps = 4/111 (3%) Query: 69 EGVKAGTKLSLMPWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCEGKV 126 E + A T MPWFHGKI+RE++E+ L+ G FL+R N G Y LC+ EGKV Sbjct: 155 EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKV 213 Query: 127 EHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGT 176 HYRI + KLSI E F+ L QLVEHY+ ADGL L P GT Sbjct: 214 LHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGT 264 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 3/94 (3%) Query: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS- 136 +P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I + Sbjct: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 Query: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 +I + L +++ ++DGL L KP Sbjct: 73 TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106 >5FM2-A nrPDB Length = 355 Score = 174 bits (440), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 103/294 (35%), Positives = 160/294 (54%), Gaps = 40/294 (13%) Query: 188 WALNMKELKLLQTIGKGEFGDV-------MLGDYRGNKVAVKCIKNDATA---QAFLAEA 237 W K L L +T+G+GEFG V + G VAVK +K +A+ + L+E Sbjct: 59 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 118 Query: 238 SVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRG-------------- 282 +V+ Q+ H ++++L G ++ G L ++ EY GSL +LR SR Sbjct: 119 NVLKQVNHPHVIKLYGACSQD-GPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 177 Query: 283 --------RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG 334 R++ GD L+ F+ + + M+YL VHRDLAARN+LV+E K+SDFG Sbjct: 178 SSLDHPDERALTMGD-LISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFG 236 Query: 335 LTKEASS-----TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR 389 L+++ + G++PVKW A E+L + ++T+SDVWSFG+LLWEI + G PYP Sbjct: 237 LSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG 296 Query: 390 IPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 IP + + ++ G++M+ PD C +Y +M CW + RP F + + LE + Sbjct: 297 IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM 350 >3ZBF-A nrPDB Length = 322 Score = 172 bits (437), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 106/287 (36%), Positives = 158/287 (55%), Gaps = 27/287 (9%) Query: 189 ALNMKELKLLQTIGKGEFGDV-------MLGDYRGN-KVAVKCIKNDATAQA---FLAEA 237 A ++L L +G G FG+V +LG G KVAVK +K +T Q FL EA Sbjct: 29 AFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEA 88 Query: 238 SVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS-- 295 +M++ H N+++ LGV + + YI+ E M G L+ YLR + G L Sbjct: 89 HLMSKFNHPNILKQLGVCLLNEPQ-YIILELMEGGDLLTYLRKARMATFYGPLLTLVDLV 147 Query: 296 ---LDVCEAMEYLEGNNFVHRDLAARNVLVSEDN-----VAKVSDFGLTKEASST----- 342 +D+ + YLE +F+HRDLAARN LVS + + K+ DFGL ++ Sbjct: 148 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 207 Query: 343 QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 + G LPV+W APE+L + F+T+SDVWSFGIL+WEI + G PYP DV+ V+ G Sbjct: 208 RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG 267 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELH 449 +++ P CP ++++M CW + RPTF ++++QL+ R L+ Sbjct: 268 GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLN 314 >1U59-A nrPDB Length = 287 Score = 172 bits (435), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 96/253 (37%), Positives = 144/253 (56%), Gaps = 16/253 (6%) Query: 201 IGKGEFGDVMLGDYRGNK----VAVKCIKN---DATAQAFLAEASVMTQLRHSNLVQLLG 253 +G G FG V G YR K VA+K +K A + + EA +M QL + +V+L+G Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 77 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 V E L +V E G L +L + R + + + V M+YLE NFVHR Sbjct: 78 VCQAE--ALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHR 134 Query: 314 DLAARNVLVSEDNVAKVSDFGLTKEAS------STQDTGKLPVKWTAPEALREKKFSTKS 367 DLAARNVL+ + AK+SDFGL+K + + GK P+KW APE + +KFS++S Sbjct: 135 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 194 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDA 427 DVWS+G+ +WE S+G+ PY ++ +V+ +E+G +M+ P CPP +Y +M +CW Sbjct: 195 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 254 Query: 428 ATRPTFLQLREQL 440 RP FL + +++ Sbjct: 255 EDRPDFLTVEQRM 267 >5KMM-A nrPDB Length = 329 Score = 169 bits (429), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 96/298 (32%), Positives = 160/298 (53%), Gaps = 30/298 (10%) Query: 173 MEGTVAAQDEFYRSGWALNMK--ELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKC 223 ++G + +++ ++K ++ L +G+G FG V L + VAVK Sbjct: 13 LQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKA 72 Query: 224 IK--NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR 281 +K +++ Q F EA ++T L+H ++V+ GV E + L +V EYM G L +LRS Sbjct: 73 LKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRP-LLMVFEYMRHGDLNRFLRSH 131 Query: 282 GRSV-------------LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA 328 G LG LL + V M YL G +FVHRDLA RN LV + V Sbjct: 132 GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV 191 Query: 329 KVSDFGLTKEASSTQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFG 383 K+ DFG++++ ST LP++W PE++ +KF+T+SDVWSFG++LWEI+++G Sbjct: 192 KIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG 251 Query: 384 RVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 + P+ ++ + + + +G +++ P CPP VY +M+ CW + R + + +L+ Sbjct: 252 KQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 309 >2OZO-A nrPDB Length = 613 Score = 169 bits (429), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 95/253 (37%), Positives = 144/253 (56%), Gaps = 16/253 (6%) Query: 201 IGKGEFGDVMLGDYRGNK----VAVKCIKN---DATAQAFLAEASVMTQLRHSNLVQLLG 253 +G G FG V G YR K VA+K +K A + + EA +M QL + +V+L+G Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 V E L +V E G L +L + R + + + V M+YLE NFVHR Sbjct: 404 VCQAE--ALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Query: 314 DLAARNVLVSEDNVAKVSDFGLTKEAS------STQDTGKLPVKWTAPEALREKKFSTKS 367 +LAARNVL+ + AK+SDFGL+K + + GK P+KW APE + +KFS++S Sbjct: 461 NLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDA 427 DVWS+G+ +WE S+G+ PY ++ +V+ +E+G +M+ P CPP +Y +M +CW Sbjct: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 Query: 428 ATRPTFLQLREQL 440 RP FL + +++ Sbjct: 581 EDRPDFLTVEQRM 593 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 40/98 (40%), Positives = 48/98 (48%), Gaps = 4/98 (4%) Query: 69 EGVKAGTKLSLMPWFHGKITREQAERLLY--PPETGLFLVRESTNYPGDYTLCVSCEGKV 126 E + A T MPW+H +TRE+AER LY G FL+R G Y L + V Sbjct: 150 EKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTV 208 Query: 127 EHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGL 163 HY I A K I E F+ L QLVE+ ADGL Sbjct: 209 YHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGL 246 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 3/94 (3%) Query: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS- 136 +P+F+G I+R +AE L GLFL+R+ G Y L + + + H+ I + Sbjct: 8 LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 67 Query: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 +I +L E Y+ D DGL L KP Sbjct: 68 TYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP 101 >5U6B-A nrPDB Length = 307 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 97/271 (35%), Positives = 152/271 (56%), Gaps = 22/271 (8%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGN----KVAVKCIK----NDATAQAFLAEASVMTQLRH 245 ++ L +T+G+GEFG VM G + KVAVK +K + + FL+EA M + H Sbjct: 24 KVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDH 83 Query: 246 SNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYL---RSRGRSV-LGGDCLLKFSL 296 N+++L+GV E ++ +M G L +L R + V L L+KF Sbjct: 84 PNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMA 143 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-----DTGKLPVK 351 D+ MEYL F+HRDLAARN +++E+ V+DFGL+K+ + K+PVK Sbjct: 144 DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK 203 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC 411 W A E+L ++ +++KSDVWSFG+ +WEI + G+ PYP + ++ + +G ++ P C Sbjct: 204 WIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADC 263 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 +Y +M CW L+ RP+F +LRE LE+ Sbjct: 264 LDGLYALMSRCWELNPQDRPSFTELREDLEN 294 >3PP0-A nrPDB Length = 338 Score = 169 bits (427), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 96/269 (35%), Positives = 152/269 (56%), Gaps = 19/269 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGN------KVAVKCIKNDATAQA---FLAEASVM 240 L EL+ ++ +G G FG V G + + VA+K ++ + + +A L EA VM Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVM 73 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRGRSVLGGDCLLKFSLDVC 299 + + +LLG+ + + +VT+ M G L+D++R +RGR LG LL + + + Sbjct: 74 AGVGSPYVSRLLGICLTST--VQLVTQLMPYGCLLDHVRENRGR--LGSQDLLNWCMQIA 129 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTA 354 + M YLE VHRDLAARNVLV N K++DFGL + E D GK+P+KW A Sbjct: 130 KGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMA 189 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414 E++ ++F+ +SDVWS+G+ +WE+ +FG PY IP +++ +EKG ++ P C Sbjct: 190 LESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTID 249 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQLEHI 443 VY +M CW +D+ RP F +L + + Sbjct: 250 VYMIMVKCWMIDSECRPRFRELVSEFSRM 278 >3G0E-A nrPDB Length = 336 Score = 168 bits (426), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 98/291 (33%), Positives = 151/291 (51%), Gaps = 34/291 (11%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDA---TAQAF 233 Y W L +T+G G FG V+ G VAVK +K A +A Sbjct: 37 YDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREAL 96 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC-- 290 ++E V++ L H N+V LLG G ++TEY G L+++LR + S + Sbjct: 97 MSELKVLSYLGNHMNIVNLLGACTI-GGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSP 155 Query: 291 --------------LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT 336 LL FS V + M +L N +HRDLAARN+L++ + K+ DFGL Sbjct: 156 AIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLA 215 Query: 337 KEASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP 391 ++ + + +LPVKW APE++ ++ +SDVWS+GI LWE++S G PYP +P Sbjct: 216 RDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMP 275 Query: 392 LKDVVPR-VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 + + +++G++M +P+ P +YD+MK CW D RPTF Q+ + +E Sbjct: 276 VDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIE 326 >2W1I-A nrPDB Length = 326 Score = 167 bits (423), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 95/282 (33%), Positives = 153/282 (54%), Gaps = 31/282 (10%) Query: 193 KELKLLQTIGKGEFGDVM------LGDYRGNKVAVKCIKNDATA--QAFLAEASVMTQLR 244 + LK LQ +GKG FG V L D G VAVK +++ + F E ++ L+ Sbjct: 41 RHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQ 100 Query: 245 HSNLVQLLGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H N+V+ GV + L ++ EY+ GSL DYL+ + + + LL+++ +C+ ME Sbjct: 101 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KHKERIDHIKLLQYTSQICKGME 159 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT------KEASSTQDTGKLPVKWTAPEA 357 YL ++HRDLA RN+LV +N K+ DFGLT KE ++ G+ P+ W APE+ Sbjct: 160 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 219 Query: 358 LREKKFSTKSDVWSFGILLWEIYSF---------------GRVPYPRIPLKDVVPRVEKG 402 L E KFS SDVWSFG++L+E++++ G ++ + ++ ++ Sbjct: 220 LTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNN 279 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 ++ PDGCP +Y +M CW+ + RP+F L +++ IR Sbjct: 280 GRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR 321 >3IO7-A nrPDB Length = 313 Score = 167 bits (423), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 95/282 (33%), Positives = 153/282 (54%), Gaps = 31/282 (10%) Query: 193 KELKLLQTIGKGEFGDVM------LGDYRGNKVAVKCIKNDATA--QAFLAEASVMTQLR 244 + LK LQ +GKG FG V L D G VAVK +++ + F E ++ L+ Sbjct: 28 RHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQ 87 Query: 245 HSNLVQLLGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H N+V+ GV + L ++ EY+ GSL DYL+ + + + LL+++ +C+ ME Sbjct: 88 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KHKERIDHIKLLQYTSQICKGME 146 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT------KEASSTQDTGKLPVKWTAPEA 357 YL ++HRDLA RN+LV +N K+ DFGLT KE ++ G+ P+ W APE+ Sbjct: 147 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 206 Query: 358 LREKKFSTKSDVWSFGILLWEIYSF---------------GRVPYPRIPLKDVVPRVEKG 402 L E KFS SDVWSFG++L+E++++ G ++ + ++ ++ Sbjct: 207 LTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNN 266 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 ++ PDGCP +Y +M CW+ + RP+F L +++ IR Sbjct: 267 GRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR 308 >3LZB-A nrPDB Length = 327 Score = 165 bits (418), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 93/261 (35%), Positives = 147/261 (56%), Gaps = 17/261 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY--RGNKV----AVKCIKNDATAQA---FLAEASVM 240 L E K ++ +G G FG V G + G KV A+K ++ + +A L EA VM Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 71 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + + ++ +LLG+ + + ++T+ M G L+DY+R + +G LL + + + + Sbjct: 72 ASVDNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVREH-KDNIGSQYLLNWCVQIAK 128 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAP 355 M YLE VHRDLAARNVLV K++DFGL K E + GK+P+KW A Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 188 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ + ++ +SDVWS+G+ +WE+ +FG PY IP ++ +EKG ++ P C V Sbjct: 189 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 248 Query: 416 YDVMKNCWHLDAATRPTFLQL 436 Y +M+ CW +DA +RP F +L Sbjct: 249 YMIMRKCWMIDADSRPKFREL 269 >3QUP-A nrPDB Length = 323 Score = 165 bits (417), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 100/280 (35%), Positives = 151/280 (53%), Gaps = 29/280 (10%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGN-----KVAVKCIKNDATAQA----FLAEASVMTQL 243 ++ L + +GKGEFG V + KVAVK +K D A + FL EA+ M + Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 244 RHSNLVQLLGVIVEE--KGGL---YIVTEYMAKGSLVDYLRSRGRSVLGGD-------CL 291 H ++ +L+GV + KG L ++ +M G L +L + S +G + L Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA---SRIGENPFNLPLQTL 139 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-----DTG 346 ++F +D+ MEYL NF+HRDLAARN +++ED V+DFGL+++ S Sbjct: 140 VRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS 199 Query: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 KLPVKW A E+L + ++ SDVW+FG+ +WEI + G+ PY I ++ + G ++ Sbjct: 200 KLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLK 259 Query: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTH 446 P C VYD+M CW D RP+F LR +LE+I H Sbjct: 260 QPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH 299 >6DBM-A nrPDB Length = 318 Score = 163 bits (412), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 101/278 (36%), Positives = 146/278 (52%), Gaps = 35/278 (12%) Query: 190 LNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVKCIKNDATAQ---AFLAEASVM 240 + + LK ++ +G+G FG V L D G VAVK +K DA Q + E ++ Sbjct: 28 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDIL 87 Query: 241 TQLRHSNLVQLLGVIVEEKGG--LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 L H ++++ G E+ G L +V EY+ GSL DYL R +G LL F+ + Sbjct: 88 RTLYHEHIIKYKGC-CEDAGAASLQLVMEYVPLGSLRDYLP---RHSIGLAQLLLFAQQI 143 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKW 352 CE M YL +++HRDLAARNVL+ D + K+ DFGL K E ++ G PV W Sbjct: 144 CEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 203 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGR--------------VPYPRIPLKDVVPR 398 APE L+E KF SDVWSFG+ L+E+ + + ++ + + Sbjct: 204 YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL 263 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 +E+G ++ PD CP VY +MKNCW +A+ RPTF L Sbjct: 264 LERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENL 301 >5GNK-A nrPDB Length = 297 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 92/261 (35%), Positives = 145/261 (55%), Gaps = 17/261 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY--RGNKV----AVKCIKNDATAQA---FLAEASVM 240 L E K ++ +G G FG V G + G KV A+K ++ + +A L EA VM Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + + ++ +LLG+ + + ++ + M G L+DY+R + +G LL + + + + Sbjct: 76 ASVDNPHVCRLLGICLTST--VQLIMQLMPFGCLLDYVREH-KDNIGSQYLLNWCVQIAK 132 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAP 355 M YLE VHRDLAARNVLV K++DFGL K E + GK+P+KW A Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 192 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ + ++ +SDVWS+G+ +WE+ +FG PY IP ++ +EKG ++ P C V Sbjct: 193 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 252 Query: 416 YDVMKNCWHLDAATRPTFLQL 436 Y +M CW +DA +RP F +L Sbjct: 253 YMIMVKCWMIDADSRPKFREL 273 >3V5Q-A nrPDB Length = 297 Score = 159 bits (403), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 89/269 (33%), Positives = 145/269 (53%), Gaps = 29/269 (10%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDATA--QAFLAEASVM 240 + +++ L + +G+G FG V L + VAVK +K+ A + F EA ++ Sbjct: 12 IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL 71 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--------------RSVL 286 T L+H ++V+ GV + L +V EYM G L +LR+ G + L Sbjct: 72 TNLQHEHIVKFYGV-CGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGEL 130 Query: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--- 343 G +L + + M YL +FVHRDLA RN LV + + K+ DFG++++ ST Sbjct: 131 GLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR 190 Query: 344 --DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 401 LP++W PE++ +KF+T+SDVWSFG++LWEI+++G+ P+ ++ +V+ + + Sbjct: 191 VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQ 250 Query: 402 GYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 G ++ P CP VYDVM CW + R Sbjct: 251 GRVLERPRVCPKEVYDVMLGCWQREPQQR 279 >4OLI-A nrPDB Length = 645 Score = 159 bits (402), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 99/278 (35%), Positives = 146/278 (52%), Gaps = 35/278 (12%) Query: 190 LNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVKCIKNDATAQ---AFLAEASVM 240 + + LK ++ +G+G FG V L D G VAVK +K D Q + E ++ Sbjct: 350 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDIL 409 Query: 241 TQLRHSNLVQLLGVIVEEKG--GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 L H ++++ G E++G L +V EY+ GSL DYL R +G LL F+ + Sbjct: 410 RTLYHEHIIKYKGC-CEDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQI 465 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKW 352 CE M YL +++HR+LAARNVL+ D + K+ DFGL K E ++ G PV W Sbjct: 466 CEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 525 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGR--------------VPYPRIPLKDVVPR 398 APE L+E KF SDVWSFG+ L+E+ + + ++ + + Sbjct: 526 YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL 585 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 +E+G ++ PD CP VY +MKNCW +A+ RPTF L Sbjct: 586 LERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 623 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 66/231 (28%), Positives = 106/231 (45%), Gaps = 20/231 (8%) Query: 230 AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 A AF AS+M+Q+ H++L + GV V + +VTEY+ G L +LR R R + Sbjct: 110 ALAFYETASLMSQVSHTHLAFVHGVCVRGPENI-MVTEYVEHGPLDVWLR-RERGHVPMA 167 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA-------KVSDFGLTKEASST 342 + + + A+ YLE N VH ++ RN+L++ +A K+SD G+ A S Sbjct: 168 WKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSR 227 Query: 343 QDTGKLPVKWTAPEALR--EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE 400 ++ + + W APE L ST D W FG L EI G PL+ P + Sbjct: 228 EERVER-IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEA-----PLQSRSPSEK 281 Query: 401 KGY---KMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHEL 448 + + + P+ P + + C + RP+F + L ++ H L Sbjct: 282 EHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNL 332 >4E20-A nrPDB Length = 290 Score = 159 bits (401), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 98/279 (35%), Positives = 147/279 (52%), Gaps = 35/279 (12%) Query: 189 ALNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVKCIKNDATAQ---AFLAEASV 239 + + LK ++ +G+G FG V L D G VAVK +K Q + E + Sbjct: 4 VFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEI 63 Query: 240 MTQLRHSNLVQLLGVIVEEKG--GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 + L H ++V+ G E++G + +V EY+ GSL DYL R +G LL F+ Sbjct: 64 LRTLYHEHIVKYKGC-CEDQGEKSVQLVMEYVPLGSLRDYL---PRHCVGLAQLLLFAQQ 119 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVK 351 +CE M YL +++HR LAARNVL+ D + K+ DFGL K E ++ G PV Sbjct: 120 ICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 179 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSF---GRVPYPR-----------IPLKDVVP 397 W APE L+E KF SDVWSFG+ L+E+ ++ + P+ + + + + Sbjct: 180 WYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTE 239 Query: 398 RVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 +E+G ++ PD CP +Y +MKNCW +A+ RPTF L Sbjct: 240 LLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNL 278 >4LRM-A nrPDB Length = 334 Score = 158 bits (399), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 93/264 (35%), Positives = 146/264 (55%), Gaps = 20/264 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY--RGNKV----AVKCIKNDATAQA---FLAEASVM 240 L E K ++ +G G FG V G + G KV A+K ++ + +A L EA VM Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 241 TQLRHS---NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 + + ++ +LLG+ + + ++T+ M G L+DY+R + +G LL + + Sbjct: 76 ASVDNPGNPHVCRLLGICLTST--VQLITQLMPFGCLLDYVREH-KDNIGSQYLLNWCVQ 132 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKW 352 + + M YLE VHRDLAARNVLV K++DFGL K E + GK+P+KW Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 A E++ + ++ +SDVWS+G+ +WE+ +FG PY IP ++ +EKG ++ P C Sbjct: 193 MALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT 252 Query: 413 PAVYDVMKNCWHLDAATRPTFLQL 436 VY +M CW +DA +RP F +L Sbjct: 253 IDVYMIMVKCWMIDADSRPKFREL 276 >1LUF-A nrPDB Length = 343 Score = 157 bits (397), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 95/288 (32%), Positives = 150/288 (52%), Gaps = 38/288 (13%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATAQA---FLAEASVMTQ 242 ++ ++ IG+G FG V G VAVK +K +A+A F EA++M + Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAE 106 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS----------------RGRSVL 286 + N+V+LLGV K + ++ EYMA G L ++LRS R R Sbjct: 107 FDNPNIVKLLGVCAVGKP-MCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSS 165 Query: 287 GGDCLLKFSLDVCEA------MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 G L + +C A M YL FVHRDLA RN LV E+ V K++DFGL++ Sbjct: 166 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 225 Query: 341 STQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 S +P++W PE++ +++T+SDVW++G++LWEI+S+G PY + ++V Sbjct: 226 SADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 285 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + V G + P+ CP +Y++M+ CW A RP+F + L+ + Sbjct: 286 IYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRM 333 >4AT3-A nrPDB Length = 299 Score = 157 bits (397), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 93/291 (31%), Positives = 152/291 (52%), Gaps = 29/291 (9%) Query: 178 AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-----NK--VAVKCIKN--DA 228 A D F + + + L + +G+G FG V L + +K VAVK +K+ D Sbjct: 1 GAMDTFVQH---IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDN 57 Query: 229 TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV--- 285 + F EA ++T L+H ++V+ GV VE L +V EYM G L +LR+ G Sbjct: 58 ARKDFHREAELLTNLQHEHIVKFYGVCVE-GDPLIMVFEYMKHGDLNKFLRAHGPDAVLM 116 Query: 286 --------LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 337 L +L + + M YL +FVHRDLA RN LV E+ + K+ DFG+++ Sbjct: 117 AEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 176 Query: 338 EASSTQ-----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392 + ST LP++W PE++ +KF+T+SDVWS G++LWEI+++G+ P+ ++ Sbjct: 177 DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSN 236 Query: 393 KDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +V+ + +G + P CP VY++M CW + R + L+++ Sbjct: 237 NEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 287 >3LMG-A nrPDB Length = 344 Score = 157 bits (396), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 92/261 (35%), Positives = 143/261 (54%), Gaps = 17/261 (6%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGN------KVAVKCIKNDATAQAFLAEASVMT---QLR 244 EL+ L+ +G G FG V G + V +K I++ + Q+F A M L Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLD 91 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H+++V+LLG+ L +VT+Y+ GSL+D++R R LG LL + + + + M Y Sbjct: 92 HAHIVRLLGLC--PGSSLQLVTQYLPLGSLLDHVRQH-RGALGPQLLLNWGVQIAKGMYY 148 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAPEALR 359 LE + VHR+LAARNVL+ + +V+DFG+ + K P+KW A E++ Sbjct: 149 LEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIH 208 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 K++ +SDVWS+G+ +WE+ +FG PY + L +V +EKG ++ P C VY VM Sbjct: 209 FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVM 268 Query: 420 KNCWHLDAATRPTFLQLREQL 440 CW +D RPTF +L + Sbjct: 269 VKCWMIDENIRPTFKELANEF 289 >6DBN-A nrPDB Length = 316 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 93/279 (33%), Positives = 149/279 (53%), Gaps = 31/279 (11%) Query: 195 LKLLQTIGKGEFGDVML------GDYRGNKVAVKCIKNDATAQAFL---AEASVMTQLRH 245 LK ++ +G+G FG V L GD G +VAVK +K ++ E ++ L H Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH 96 Query: 246 SNLVQLLGVIVEEKG-GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 N+V+ G+ E+ G G+ ++ E++ GSL +YL + ++ + LK+++ +C+ M+Y Sbjct: 97 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYL-PKNKNKINLKQQLKYAVQICKGMDY 155 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT------KEASSTQDTGKLPVKWTAPEAL 358 L +VHRDLAARNVLV ++ K+ DFGLT KE + +D PV W APE L Sbjct: 156 LGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECL 215 Query: 359 REKKFSTKSDVWSFGILLWEIYS-----------FGRVPYP---RIPLKDVVPRVEKGYK 404 + KF SDVWSFG+ L E+ + F ++ P ++ + +V +++G + Sbjct: 216 MQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKR 275 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + P CP VY +M+ CW + R +F L E E + Sbjct: 276 LPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL 314 >3HNG-A nrPDB Length = 360 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 71/156 (45%), Positives = 102/156 (65%), Gaps = 6/156 (3%) Query: 291 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----T 345 L+ +S V ME+L +HRDLAARN+L+SE+NV K+ DFGL ++ D Sbjct: 201 LISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGD 260 Query: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL-KDVVPRVEKGYK 404 +LP+KW APE++ +K +STKSDVWS+G+LLWEI+S G PYP + + +D R+ +G + Sbjct: 261 TRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMR 320 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 M AP+ P +Y +M +CWH D RP F +L E+L Sbjct: 321 MRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 356 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 38/107 (35%), Positives = 59/107 (55%), Gaps = 11/107 (10%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDATA---QAFLA 235 S W + LKL +++G+G FG V+ G K VAVK +K ATA +A + Sbjct: 20 SKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMT 79 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR 281 E ++T + H N+V LLG ++ G L ++ EY G+L +YL+S+ Sbjct: 80 ELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSK 126 >5WNO-A nrPDB Length = 330 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 88/261 (33%), Positives = 138/261 (52%), Gaps = 15/261 (5%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDAT-AQAFLAEASVMTQLRH 245 + KL + +G G FG V G Y + VA+K + D + L EA+ M +LRH Sbjct: 23 QTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRH 82 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 NL++++G + + G L IVT Y G+L ++L+ + LG + + + M+YL Sbjct: 83 DNLLKIIGFCMHDDG-LKIVTIYRPLGNLQNFLKLHKEN-LGAREQVLYCYQIASGMQYL 140 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAPEALRE 360 E VHRDLA RNVLV + N +++DFGL+K S T +GK+ +KW A E + Sbjct: 141 EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 ++ SDVW+FG+ WEI +FG+ PY + + ++ G ++ P C +Y + Sbjct: 201 HCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELL 260 Query: 421 NCWHLDAATRPTFLQLREQLE 441 CW D +RP F L E+ + Sbjct: 261 RCWMADPKSRPGFEILYERFK 281 >3ZZW-A nrPDB Length = 289 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 88/280 (31%), Positives = 142/280 (50%), Gaps = 30/280 (10%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATA---QAFLAEASV 239 +++ ++ ++ +G+ FG V G G VA+K +K+ A + F EA + Sbjct: 6 ISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAML 65 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--------------RSV 285 +L+H N+V LLGV+ +++ L ++ Y + G L ++L R +S Sbjct: 66 RARLQHPNVVCLLGVVTKDQP-LSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSA 124 Query: 286 LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-- 343 L + + MEYL ++ VH+DLA RNVLV + K+SD GL +E + Sbjct: 125 LEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYY 184 Query: 344 ---DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE 400 LP++W APEA+ KFS SD+WS+G++LWE++S+G PY +DVV + Sbjct: 185 KLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIR 244 Query: 401 KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 + PD CP VY +M CW+ + RP F + +L Sbjct: 245 NRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL 284 >4HVI-A nrPDB Length = 314 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 97/280 (34%), Positives = 145/280 (51%), Gaps = 30/280 (10%) Query: 193 KELKLLQTIGKGEFGDV------MLGDYRGNKVAVKCIKNDATAQA--FLAEASVMTQLR 244 + LK + +GKG FG V LGD G VAVK +++ Q F E ++ L Sbjct: 10 RHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALH 69 Query: 245 HSNLVQLLGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +V+ GV + L +V EY+ G L D+L+ R R+ L LL +S +C+ ME Sbjct: 70 SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ-RHRARLDASRLLLYSSQICKGME 128 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPVKWTAPEA 357 YL VHRDLAARN+LV + K++DFGL K +D G+ P+ W APE+ Sbjct: 129 YLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPES 188 Query: 358 LREKKFSTKSDVWSFGILLWEIYSF-GRVPYPRIPLKDV------VPRVEK-------GY 403 L + FS +SDVWSFG++L+E++++ + P + VP + + G Sbjct: 189 LSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQ 248 Query: 404 KMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 ++ AP CP V+++MK CW RP+F L QL+ + Sbjct: 249 RLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDML 288 >4RT7-A nrPDB Length = 415 Score = 148 bits (373), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 73/159 (45%), Positives = 101/159 (63%), Gaps = 6/159 (3%) Query: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 343 +VL + LL F+ V + ME+LE + VHRDLAARNVLV+ V K+ DFGL ++ S Sbjct: 238 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS 297 Query: 344 D-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK-DVVP 397 + +LPVKW APE+L E ++ KSDVWS+GILLWEI+S G PYP IP+ + Sbjct: 298 NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK 357 Query: 398 RVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 ++ G+KMD P +Y +M++CW D+ RP+F L Sbjct: 358 LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 38/109 (34%), Positives = 56/109 (51%), Gaps = 12/109 (11%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATA---QAF 233 Y W + L+ + +G G FG VM G +VAVK +K A + +A Sbjct: 56 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 115 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR 281 ++E +MTQL H N+V LLG G +Y++ EY G L++YLRS+ Sbjct: 116 MSELKMMTQLGSHENIVNLLGACTL-SGPIYLIFEYCCYGDLLNYLRSK 163 >3VHK-A nrPDB Length = 368 Score = 147 bits (372), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 68/159 (42%), Positives = 103/159 (64%), Gaps = 6/159 (3%) Query: 291 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----T 345 L+ +S V + ME+L +HRDLAARN+L+SE NV K+ DFGL ++ D Sbjct: 202 LICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGD 261 Query: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL-KDVVPRVEKGYK 404 +LP+KW APE + ++ ++ +SDVWSFG+LLWEI+S G PYP + + ++ R+++G + Sbjct: 262 ARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR 321 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 M APD P +Y M +CWH + + RPTF +L E L ++ Sbjct: 322 MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNL 360 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 36/107 (33%), Positives = 54/107 (50%), Gaps = 11/107 (10%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATA---QAFLA 235 S W LKL + +G+G FG V+ D G VAVK +K AT +A ++ Sbjct: 22 SKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMS 81 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR 281 E ++ + H N+V LLG + G L ++ E+ G+L YLRS+ Sbjct: 82 ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSK 128 >6FEX-A nrPDB Length = 321 Score = 147 bits (370), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 90/291 (30%), Positives = 145/291 (49%), Gaps = 46/291 (15%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNK------------------VAVKCIKNDATAQA---F 233 L+ + +G+G+FG+V L + + VAVK ++ DAT A F Sbjct: 18 LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDF 77 Query: 234 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR-----------G 282 L E +M++L+ N+++LLGV V++ L ++T+YM G L +L + G Sbjct: 78 LKEVKIMSRLKDPNIIRLLGVCVQDDP-LCMITDYMENGDLNQFLSAHQLEDKAAEGAPG 136 Query: 283 RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS- 341 + LL + + M YL NFVHRDLA RN LV E+ K++DFG+++ + Sbjct: 137 DPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG 196 Query: 342 ----TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV-PYPRIPLKDVV 396 Q LP++W A E + KF+T SDVW+FG+ LWE+ R P+ ++ + V+ Sbjct: 197 DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVI 256 Query: 397 PRVEKGYK-------MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 + ++ + P CP +Y++M CW ++ RP F QL L Sbjct: 257 ENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL 307 >6FER-A nrPDB Length = 309 Score = 145 bits (365), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 92/288 (31%), Positives = 149/288 (51%), Gaps = 47/288 (16%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK------------------VAVKCIKNDATAQA-- 232 K L + +G+G+FG+V L + G + VAVK ++ DA A Sbjct: 9 KLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARN 68 Query: 233 -FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR---------SRG 282 FL E +M++L+ N++ LL V + + L ++TEYM G L +L S Sbjct: 69 DFLKEIKIMSRLKDPNIIHLLAVCITDDP-LCMITEYMENGDLNQFLSRHEPPNSSSSDV 127 Query: 283 RSVLGGDCLLKF-SLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS 341 R+V + LKF + + M+YL NFVHRDLA RN LV ++ K++DFG+++ S Sbjct: 128 RTVSYTN--LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYS 185 Query: 342 -----TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGR-VPYPRIPLKDV 395 Q LP++W + E++ KF+T SDVW+FG+ LWE ++F + PY ++ + V Sbjct: 186 GDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQV 245 Query: 396 VPRVEKGYK-------MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 + + ++ + P CP +VY +M +CW D RP+F ++ Sbjct: 246 IENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 293 >5VO2-A nrPDB Length = 300 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 85/259 (32%), Positives = 140/259 (54%), Gaps = 16/259 (6%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASV--MTQLRH 245 W + +E+ LQ +G G G V LG + G +VAVK +++ L E + + +L+H Sbjct: 7 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD-------LKETDIKHLRKLKH 59 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N++ GV + I+ E+ A+G L + LR+ GR V L+ +S+ + M YL Sbjct: 60 PNIITFKGVCTQAPC-YCILMEFCAQGQLYEVLRA-GRPVTPS-LLVDWSMGIAGGMNYL 116 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS--STQDTGKLPVKWTAPEALREKKF 363 + +HRDL + N+L++ D+V K+SDFG +KE S ST+ + V W APE +R + Sbjct: 117 HLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV 176 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-EKGYKMDAPDGCPPAVYDVMKNC 422 S K D+WSFG++LWE+ + G +PY + ++ V + P CP +++ C Sbjct: 177 SEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQC 235 Query: 423 WHLDAATRPTFLQLREQLE 441 W+ RP+F Q+ L+ Sbjct: 236 WNSKPRNRPSFRQILLHLD 254 >6BSD-A nrPDB Length = 876 Score = 142 bits (359), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 91/297 (30%), Positives = 147/297 (49%), Gaps = 52/297 (17%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNK------------------VAVKCIKNDATAQA---F 233 L+ + +G+G+FG+V L + + VAVK ++ DAT A F Sbjct: 573 LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDF 632 Query: 234 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR------------ 281 L E +M++L+ N+++LLGV V++ L ++T+YM G L +L + Sbjct: 633 LKEVKIMSRLKDPNIIRLLGVCVQDDP-LCMITDYMENGDLNQFLSAHQLEDKAAEGAPG 691 Query: 282 -GRSVLGGDC----LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT 336 G++ G LL + + M YL NFVHRDLA RN LV E+ K++DFG++ Sbjct: 692 DGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMS 751 Query: 337 KEASS-----TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV-PYPRI 390 + + Q LP++W A E + KF+T SDVW+FG+ LWE+ R P+ ++ Sbjct: 752 RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQL 811 Query: 391 PLKDVVPRVEKGYK-------MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 + V+ + ++ + P CP +Y++M CW ++ RP F QL L Sbjct: 812 TDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL 868 >3PPZ-A nrPDB Length = 309 Score = 140 bits (353), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 91/261 (34%), Positives = 142/261 (54%), Gaps = 13/261 (4%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGNKVAVKCI-KNDATAQ---AFLAEASVMTQLRHSNLV 249 +L + + IG G FG V ++ G+ VAVK + + D A+ FL E ++M +LRH N+V Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIV 97 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG-RSVLGGDCLLKFSLDVCEAMEYLEGN 308 +G + + L IVTEY+++GSL L G R L L + DV + M YL Sbjct: 98 LFMGAVTQPPN-LSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNR 156 Query: 309 N--FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEALREKKF 363 N VHRDL + N+LV + KV DFGL++ +ST + K +W APE LR++ Sbjct: 157 NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPS 216 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYDVMKNC 422 + KSDV+SFG++LWE+ + + P+ + VV V K +++ P P V +++ C Sbjct: 217 NEKSDVYSFGVILWELATLQQ-PWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGC 275 Query: 423 WHLDAATRPTFLQLREQLEHI 443 W + RP+F + + L + Sbjct: 276 WTNEPWKRPSFATIMDLLRPL 296 >5X5O-A nrPDB Length = 310 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 83/263 (31%), Positives = 134/263 (50%), Gaps = 19/263 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSN 247 + +L+ + G G FG V + + +VAVK + EA +++ L H N Sbjct: 12 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------IEKEAEILSVLSHRN 65 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 ++Q GVI+E IVTEY + GSL DY+ S + D ++ ++ DV + M YL Sbjct: 66 IIQFYGVILEPPN-YGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHM 124 Query: 308 N---NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD---TGKLPVKWTAPEALREK 361 +HRDL +RNV+++ D V K+ DFG ++ + T G P W APE ++ Sbjct: 125 EAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFP--WMAPEVIQSL 182 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIP-LKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 S D +S+G++LWE+ + VP+ + L+ VEK ++ P CP + +++ Sbjct: 183 PVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 241 Query: 421 NCWHLDAATRPTFLQLREQLEHI 443 CW DA RP+F Q+ LE + Sbjct: 242 QCWEADAKKRPSFKQIISILESM 264 >4UYA-A nrPDB Length = 340 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 89/271 (32%), Positives = 132/271 (48%), Gaps = 24/271 (8%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKND------ATAQAFLAEASVMTQLRH 245 + L+L + IG G FG V ++G +VAVK + D A A++ EA + LRH Sbjct: 25 FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH 84 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+++L GV +++ L +V E+ G+L L R + L+ +++ + M YL Sbjct: 85 PNIIELRGVCLQQPH-LCLVLEFARGGALNRALAGRR---IPPHVLVNWAVQIARGMLYL 140 Query: 306 EGNNFV---HRDLAARNVLVSE--------DNVAKVSDFGLTKEASSTQDTGKL-PVKWT 353 FV HRDL + N+L+ E + K++DFGL +E T W Sbjct: 141 HEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWM 200 Query: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCP 412 APE ++ FS SD+WS+G+LLWE+ + G VPY I V V + P CP Sbjct: 201 APEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCP 259 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +MK CW D RP+F + EQL I Sbjct: 260 EPFAKLMKECWQQDPHIRPSFALILEQLTAI 290 >3DTC-A nrPDB Length = 271 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 141/273 (51%), Gaps = 24/273 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDA------TAQAFLAEASVMTQL 243 ++ EL L + IG G FG V + G++VAVK ++D T + EA + L Sbjct: 4 IDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAML 63 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +H N++ L GV ++E L +V E+ A+G ++ + S R + D L+ +++ + M Sbjct: 64 KHPNIIALRGVCLKEPN-LCLVMEF-ARGGPLNRVLSGKR--IPPDILVNWAVQIARGMN 119 Query: 304 YLEGNNFV---HRDLAARNVLVSE--------DNVAKVSDFGLTKE-ASSTQDTGKLPVK 351 YL V HRDL + N+L+ + + + K++DFGL +E +T+ + Sbjct: 120 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYA 179 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPDG 410 W APE +R FS SDVWS+G+LLWE+ + G VP+ I V V + P Sbjct: 180 WMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLALPIPST 238 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 CP +M++CW+ D +RP+F + +QL I Sbjct: 239 CPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTI 271 >4UY9-A nrPDB Length = 323 Score = 130 bits (326), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 141/273 (51%), Gaps = 24/273 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDA------TAQAFLAEASVMTQL 243 ++ EL L + IG G FG V + G++VAVK ++D T + EA + L Sbjct: 6 IDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAML 65 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +H N++ L GV ++E L +V E+ A+G ++ + S R + D L+ +++ + M Sbjct: 66 KHPNIIALRGVCLKEPN-LCLVMEF-ARGGPLNRVLSGKR--IPPDILVNWAVQIARGMN 121 Query: 304 YLEGNNFV---HRDLAARNVLVSE--------DNVAKVSDFGLTKE-ASSTQDTGKLPVK 351 YL V HRDL + N+L+ + + + K++DFGL +E +T+ + Sbjct: 122 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYA 181 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPDG 410 W APE +R FS SDVWS+G+LLWE+ + G VP+ I V V + P Sbjct: 182 WMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLALPIPST 240 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 CP +M++CW+ D +RP+F + +QL I Sbjct: 241 CPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTI 273 >4NEU-A nrPDB Length = 333 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 88/284 (30%), Positives = 140/284 (49%), Gaps = 39/284 (13%) Query: 189 ALNMKELKLLQT--IGKGEFGDVMLGDYRGNKVAV--------KCIKNDATAQAFLAEAS 238 + MK L++ + G FG V L +R + + CI+++ +A L EA Sbjct: 18 VIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHN---EALLEEAK 74 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 +M +LRHS +V+LLGVI+EE G +V EYM KG+L+ L++ + L + L++ Sbjct: 75 MMNRLRHSRVVKLLGVIIEE-GKYSLVMEYMEKGNLMHVLKAEMSTPLSVKG--RIILEI 131 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT----------------KEASST 342 E M YL G +H+DL N+LV D K++D GL +E T Sbjct: 132 IEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGT 191 Query: 343 QDTGKLPVKWTAPEALRE--KKFSTKSDVWSFGILLWEIYSFGRVPYPR-IPLKDVVPRV 399 + + APE L + K + KSDV+SF ++LW I++ + PY I + ++ + Sbjct: 192 AKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCI 250 Query: 400 EKGYKMDAPD---GCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 + G + D D CP + +MK CW + RPTF + E+ Sbjct: 251 KSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKF 294 >4YFF-A nrPDB Length = 311 Score = 121 bits (304), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 84/275 (30%), Positives = 135/275 (49%), Gaps = 27/275 (9%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVK-------CIKNDATAQAFLAEAS 238 S + L + E++ + IG G FG V G R VA+K C K+D F E S Sbjct: 35 SHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDV--DMFCREVS 92 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 ++ QL H ++Q +G + + IVT+Y++ GSL L + R +L L ++DV Sbjct: 93 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKR-ILDLQSKLIIAVDV 151 Query: 299 CEAMEYLEG--NNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPV 350 + MEYL +HRDL + N+L+ ED A V+DFG ++ E + T+ G L Sbjct: 152 AKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL-- 209 Query: 351 KWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD 409 +W APE + +++ K+DV+S+ + LWEI + G +P+ LK + Y P Sbjct: 210 RWMAPEVFTQCTRYTIKADVFSYALCLWEILT-GEIPFAH--LKPAAAAADMAYHHIRPP 266 Query: 410 ---GCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 P + ++ W+ RP F ++ +LE Sbjct: 267 IGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE 301 >3OMV-A nrPDB Length = 307 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 89/275 (32%), Positives = 136/275 (49%), Gaps = 30/275 (10%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKN-DATA---QAFLAEASVMTQL 243 W + E+ L IG G FG V G + G+ VAVK +K D T QAF E +V+ + Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKT 89 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 RH N++ +G + K L IVT++ SL +L + + L+ + + M+ Sbjct: 90 RHVNILLFMGYMT--KDNLAIVTQWCEGSSLYKHLHVQ-ETKFQMFQLIDIARQTAQGMD 146 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-------TQDTGKLPVKWTAPE 356 YL N +HRD+ + N+ + E K+ DFGL S Q TG V W APE Sbjct: 147 YLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS--VLWMAPE 204 Query: 357 ALR---EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD-VVPRVEKGYKMDAPD--- 409 +R FS +SDV+S+GI+L+E+ + G +PY I +D ++ V +GY +PD Sbjct: 205 VIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYA--SPDLSK 261 Query: 410 ---GCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 CP A+ ++ +C RP F Q+ +E Sbjct: 262 LYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 296 >5ES1-A nrPDB Length = 328 Score = 118 bits (295), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 86/250 (34%), Positives = 129/250 (51%), Gaps = 14/250 (5%) Query: 196 KLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK----NDATAQAFLAEASVMTQLRHSNLV 249 +LL+TIGKG F V L + G +VA+K I N ++ Q E +M L H N+V Sbjct: 18 RLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIV 77 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 +L VI EK LY+V EY + G + DYL S GR + + KF + A+ Y N Sbjct: 78 KLFEVIETEKT-LYLVMEYASAGEVFDYLVSHGR-MKEKEARAKFR-QIVSAVHYCHQKN 134 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKEAS--STQDTGKLPVKWTAPEALREKKFS-TK 366 VHRDL A N+L+ + K++DFG + E + S DT + APE + KK+ + Sbjct: 135 IVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPE 194 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 D+WS G++L+ + S G +P+ LK++ RV +G K P +++ L+ Sbjct: 195 VDIWSLGVILYTLVS-GSLPFDGHNLKELRERVLRG-KYRVPFYMSTDCESILRRFLVLN 252 Query: 427 AATRPTFLQL 436 A R T Q+ Sbjct: 253 PAKRCTLEQI 262 >5HVK-A nrPDB Length = 315 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 87/277 (31%), Positives = 135/277 (48%), Gaps = 38/277 (13%) Query: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIK--NDATAQAFLAEASVMTQLRHSNLVQLLGV 254 + +GKG FG + +R G + +K + ++ T + FL E VM L H N+++ +GV Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGV 79 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + ++K L +TEY+ G+L ++S S + F+ D+ M YL N +HR+ Sbjct: 80 LYKDKR-LNFITEYIKGGTLRGIIKSMD-SQYPWSQRVSFAKDIASGMAYLHSMNIIHRN 137 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEA--SSTQDTGKLPVK---------------WTAPEA 357 L + N LV E+ V+DFGL + TQ G +K W APE Sbjct: 138 LNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEM 197 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE------KGYKMD--APD 409 + + + K DV+SFGI+L EI GRV D +PR +G+ +D P Sbjct: 198 INGRSYDEKVDVFSFGIVLCEI--IGRVNAD----PDYLPRTMDFGLNVRGF-LDRYCPP 250 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTH 446 CPP+ + + C LD RP+F++L LE +R H Sbjct: 251 NCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMH 287 >5HI2-A nrPDB Length = 283 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 80/271 (29%), Positives = 133/271 (49%), Gaps = 23/271 (8%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSN 247 W + ++ + Q IG G FG V G + G+ VAVK + QAF E V+ + RH N Sbjct: 15 WEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKML-TPQQLQAFKNEVGVLRKTRHVN 72 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 ++ +G K L IVT++ SL +L + + L+ + M+YL Sbjct: 73 ILLFMGY--STKPQLAIVTQWCEGSSLYHHLHA-SETKFEMKKLIDIARQTARGMDYLHA 129 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-----PVKWTAPEALR--- 359 + +HRDL + N+ + EDN K+ DFGL S + + + W APE +R Sbjct: 130 KSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 189 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD-VVPRVEKGYKMDAPD------GCP 412 +S +SDV++FGI+L+E+ + G++PY I +D ++ V +G +PD CP Sbjct: 190 SNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSL--SPDLSKVRSNCP 246 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + +M C RP+F ++ ++E + Sbjct: 247 KRMKRLMAECLKKKRDERPSFPRILAEIEEL 277 >5KZ7-A nrPDB Length = 346 Score = 115 bits (288), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 86/250 (34%), Positives = 130/250 (52%), Gaps = 14/250 (5%) Query: 196 KLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK----NDATAQAFLAEASVMTQLRHSNLV 249 +LL+TIGKG F V L + G +VAVK I N ++ Q E +M L H N+V Sbjct: 36 RLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIV 95 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 +L VI EK LY+V EY + G + DYL + GR + + KF + A++Y Sbjct: 96 KLFEVIETEKT-LYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFR-QIVSAVQYCHQKF 152 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKEAS--STQDTGKLPVKWTAPEALREKKFS-TK 366 VHRDL A N+L+ D K++DFG + E + + DT + APE + KK+ + Sbjct: 153 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPE 212 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 DVWS G++L+ + S G +P+ LK++ RV +G K P +++K L+ Sbjct: 213 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLILN 270 Query: 427 AATRPTFLQL 436 + R T Q+ Sbjct: 271 PSKRGTLEQI 280 >4GS6-A nrPDB Length = 315 Score = 114 bits (284), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 71/261 (27%), Positives = 128/261 (49%), Gaps = 11/261 (4%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLV 249 ++ KE+++ + +G+G FG V +R VA+K I++++ +AF+ E ++++ H N+V Sbjct: 6 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIV 65 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRGRSVLGGDCLLKFSLDVCEAMEYL--- 305 +L G + + +V EY GSL + L + + + L + + YL Sbjct: 66 KLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 306 EGNNFVHRDLAARN-VLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFS 364 + +HRDL N +LV+ V K+ DFG + + K W APE +S Sbjct: 123 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYS 182 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRI--PLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 K DV+S+GI+LWE+ + R P+ I P ++ V G + P + +M C Sbjct: 183 EKCDVFSWGIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRC 241 Query: 423 WHLDAATRPTFLQLREQLEHI 443 W D + RP+ ++ + + H+ Sbjct: 242 WSKDPSQRPSMEEIVKIMTHL 262 >5HIE-A nrPDB Length = 302 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 82/269 (30%), Positives = 132/269 (49%), Gaps = 23/269 (8%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSN 247 W + ++ + Q IG G FG V G + G+ VAVK + QAF E V+ + RH N Sbjct: 31 WEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKML-TPQQLQAFKNEVGVLRKTRHVN 88 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 ++ +G K L IVT++ SL +L + L+ + + M+YL Sbjct: 89 ILLFMGY--STKPQLAIVTQWCEGSSLYHHLHII-ETKFEMIKLIDIARQTAQGMDYLHA 145 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-----PVKWTAPEALR--- 359 + +HRDL + N+ + ED K+ DFGL S + + + W APE +R Sbjct: 146 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 205 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD-VVPRVEKGYKMDAPD------GCP 412 + +S +SDV++FGI+L+E+ + G++PY I +D ++ V +GY +PD CP Sbjct: 206 KNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYL--SPDLSKVRSNCP 262 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLE 441 A+ +M C RP F Q+ +E Sbjct: 263 KAMKRLMAECLKKKRDERPLFPQILASIE 291 >2QNJ-A nrPDB Length = 328 Score = 112 bits (279), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 84/250 (33%), Positives = 126/250 (50%), Gaps = 14/250 (5%) Query: 196 KLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK----NDATAQAFLAEASVMTQLRHSNLV 249 +LL+TIGKG F V L + G +VA+K I N + Q E +M L H N+V Sbjct: 15 RLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 74 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 +L VI EK LY++ EY + G + DYL + GR + + KF + A++Y Sbjct: 75 KLFEVIETEKT-LYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFR-QIVSAVQYCHQKR 131 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKE--ASSTQDTGKLPVKWTAPEALREKKFS-TK 366 VHRDL A N+L+ D K++DFG + E DT + APE + KK+ + Sbjct: 132 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPE 191 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 DVWS G++L+ + S G +P+ LK++ RV +G K P +++K L+ Sbjct: 192 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVLN 249 Query: 427 AATRPTFLQL 436 R T Q+ Sbjct: 250 PIKRGTLEQI 259 >4YNZ-A nrPDB Length = 342 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 77/260 (29%), Positives = 137/260 (52%), Gaps = 21/260 (8%) Query: 196 KLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLA----EASVMTQLRHSNLV 249 +L +T+GKG+ G V LG + KVA+K + + +++ L E +++ + H +++ Sbjct: 13 RLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVL 72 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 +L V E K LY+V E+++ G L DYL +GR L KF + A+++ ++ Sbjct: 73 KLHDV-YENKKYLYLVLEHVSGGELFDYLVKKGR--LTPKEARKFFRQIISALDFCHSHS 129 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLT--KEASSTQDTGKLPVKWTAPEALREKKFS-TK 366 HRDL N+L+ E N +++DFG+ + S +T + PE +R +K+ K Sbjct: 130 ICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRK 189 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 +DVWS G++L+ + G +P+ L+ ++ +V++G P PP +++ +D Sbjct: 190 ADVWSCGVILFALL-VGALPFDDDNLRQLLEKVKRGV-FHMPHFIPPDCQSLLRGMIEVD 247 Query: 427 AATRPTFLQLREQLEHIRTH 446 AA R T LEHI+ H Sbjct: 248 AARRLT-------LEHIQKH 260 >2HAK-A nrPDB Length = 328 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 78/216 (36%), Positives = 114/216 (52%), Gaps = 13/216 (6%) Query: 196 KLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK----NDATAQAFLAEASVMTQLRHSNLV 249 +L +TIGKG F V L + G +VAVK I N + Q E +M L H N+V Sbjct: 18 RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 77 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 +L VI EK LY+V EY + G + DYL + GR + + KF + A++Y Sbjct: 78 KLFEVIETEKT-LYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFR-QIVSAVQYCHQKY 134 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKE--ASSTQDTGKLPVKWTAPEALREKKFS-TK 366 VHRDL A N+L+ D K++DFG + E + DT + APE + KK+ + Sbjct: 135 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPE 194 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 DVWS G++L+ + S G +P+ LK++ RV +G Sbjct: 195 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRG 229 >4TPT-A nrPDB Length = 303 Score = 107 bits (268), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 79/281 (28%), Positives = 133/281 (47%), Gaps = 47/281 (16%) Query: 199 QTIGKGEFGDVMLGDYRGN------KVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLL 252 + +GKG FG + ++ K ++C ++ T + FL E VM L H N+++ + Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRC--DEETQKTFLTEVKVMRSLDHPNVLKFI 63 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 GV+ ++K L ++TEY+ G+L D+LRS ++F+ + M YL +H Sbjct: 64 GVLYKDKK-LNLLTEYIEGGTLKDFLRSM--DPFPWQQKVRFAKGIASGMAYLHSMCIIH 120 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTK------------EASSTQDTGKLPVK--------- 351 RDL + N L+ D V+DFGL++ +A++ + T + + Sbjct: 121 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180 Query: 352 --WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR-------VEKG 402 W APE L K + D++SFGI+L EI G+V D +PR V+ Sbjct: 181 PYWMAPEMLNGKSYDETVDIFSFGIVLCEI--IGQV----YADPDCLPRTLDFGLNVKLF 234 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 ++ P CPPA + + C L+ +RP F +L + E + Sbjct: 235 WEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 275 >6C9D-A nrPDB Length = 459 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 76/216 (35%), Positives = 113/216 (52%), Gaps = 13/216 (6%) Query: 196 KLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK----NDATAQAFLAEASVMTQLRHSNLV 249 +L +TIGKG F V L + G +VAVK I N + Q E +M L H N+V Sbjct: 24 RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 83 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 +L VI EK LY+V EY + G + DYL + GR + + KF + A++Y Sbjct: 84 KLFEVIETEKT-LYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFR-QIVSAVQYCHQKY 140 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALREKKFS-TK 366 VHRDL A N+L+ D K++DFG + E + + + APE + KK+ + Sbjct: 141 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPE 200 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 DVWS G++L+ + S G +P+ LK++ RV +G Sbjct: 201 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRG 235 >3MDY-A nrPDB Length = 337 Score = 105 bits (261), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 80/293 (27%), Positives = 135/293 (46%), Gaps = 48/293 (16%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL-RHSNLVQL 251 K++++++ IGKG +G+V +G +RG KVAVK A F T L RH N++ Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 96 Query: 252 LGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 + ++ G LY++T+Y GSL DYL+S + L +LK + + +L Sbjct: 97 IAADIKGTGSWTQLYLITDYHENGSLYDYLKS---TTLDAKSMLKLAYSSVSGLCHLHTE 153 Query: 309 NF--------VHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKWT 353 F HRDL ++N+LV ++ ++D GL + S + +P ++ Sbjct: 154 IFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYM 213 Query: 354 APEALREK------KFSTKSDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPRVEKGY 403 PE L E + +D++SFG++LWE+ S G V ++P D+VP Sbjct: 214 PPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYE 273 Query: 404 KMD----------------APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 M + D C + +M CW + A+R T L++++ L Sbjct: 274 DMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL 326 >4F0G-A nrPDB Length = 287 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/274 (28%), Positives = 137/274 (50%), Gaps = 30/274 (10%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGNK--VAVKC-IKNDATA--------QAFLAEASVMTQ 242 E++ + IGKG FG V G +K VA+K I D+ Q F E +M+ Sbjct: 20 EIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSN 79 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L H N+V+L G++ +V E++ G L L + + L+ LD+ + Sbjct: 80 LNHPNIVKLYGLMHNPP---RMVMEFVPCGDLYHRLLDKAHPI-KWSVKLRLMLDIALGI 135 Query: 303 EYLEGNN--FVHRDLAARNVLVS--EDNV---AKVSDFGLTKEASSTQDTGKLPVKWTAP 355 EY++ N VHRDL + N+ + ++N AKV+DFGL++++ + +W AP Sbjct: 136 EYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAP 195 Query: 356 EAL--REKKFSTKSDVWSFGILLWEIYS----FGRVPYPRIPLKDVVPRVEKGYKMDAPD 409 E + E+ ++ K+D +SF ++L+ I + F Y +I +++ E+G + P+ Sbjct: 196 ETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMI--REEGLRPTIPE 253 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 CPP + +V++ CW D RP F + ++L + Sbjct: 254 DCPPRLRNVIELCWSGDPKKRPHFSYIVKELSEL 287 >1PY5-A nrPDB Length = 326 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 139/300 (46%), Gaps = 48/300 (16%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFL-AEASVMTQLRHSNLVQL 251 + + L ++IGKG FG+V G +RG +VAVK + F AE LRH N++ Sbjct: 29 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 88 Query: 252 LGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 + ++ G L++V++Y GSL DYL +V G ++K +L + +L Sbjct: 89 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEG---MIKLALSTASGLAHLHME 145 Query: 309 --------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKWT 353 HRDL ++N+LV ++ ++D GL S DT + ++ Sbjct: 146 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 205 Query: 354 APEALRE----KKFST--KSDVWSFGILLWEIY---SFGRVPYP-RIPLKDVV---PRVE 400 APE L + K F + ++D+++ G++ WEI S G + ++P D+V P VE Sbjct: 206 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVE 265 Query: 401 KGYKMDAPDGCPPAVYD-------------VMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 + K+ P + + +M+ CW+ + A R T L++++ L + E Sbjct: 266 EMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQE 325 >1GRI-A nrPDB Length = 217 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 53/147 (36%), Positives = 84/147 (57%), Gaps = 12/147 (8%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72 E IAKY+F TA+ +L F +GD+L ++ D NWYKA+ G++G IP NY++ Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYIE------ 54 Query: 73 AGTKLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSCEGKVEHYRI 131 + PWF GKI R +AE +L G FL+RES + PGD++L V V+H+++ Sbjct: 55 ----MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV 110 Query: 132 MYHASKLSIDEEVYFENLMQLVEHYTT 158 + + V F +L +LV+++ + Sbjct: 111 LRDGAGKYFLWVVKFNSLNELVDYHRS 137 >2Y4I-B nrPDB Length = 319 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 135/288 (46%), Gaps = 27/288 (9%) Query: 178 AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCI----KNDATAQAF 233 A+Q + W + ++L++ + IGKG FG V G + G +VA++ I N+ +AF Sbjct: 18 ASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAF 76 Query: 234 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 293 E Q RH N+V +G + L I+T +L +R + VL + + Sbjct: 77 KREVMAYRQTRHENVVLFMGACMSPP-HLAIITSLCKGRTLYSVVRD-AKIVLDVNKTRQ 134 Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKL 348 + ++ + M YL +H+DL ++NV V ++DFGL +A +D ++ Sbjct: 135 IAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGVLQAGRREDKLRI 193 Query: 349 PVKW---TAPEALREKK---------FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396 W APE +R+ FS SDV++ G + +E+++ P+ P + ++ Sbjct: 194 QNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA-REWPFKTQPAEAII 252 Query: 397 PRVEKGYKMDAPD-GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 ++ G K + G + D++ CW + RPTF +L + LE + Sbjct: 253 WQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 300 >3REP-A nrPDB Length = 271 Score = 98.2 bits (243), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 74/267 (27%), Positives = 130/267 (48%), Gaps = 16/267 (5%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK----NDATAQAFLAEASVMTQLRH 245 ++ K+L L + + G++ G ++GN + VK +K + ++ F E + H Sbjct: 7 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 66 Query: 246 SNLVQLLGVIVEEKGG-LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 N++ +LG ++T +M GSL + L V+ +KF+LD+ M + Sbjct: 67 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAF 126 Query: 305 LEG-NNFVHRD-LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-PVKWTAPEALREK 361 L + R L +R+V++ ED A++S + S Q G++ W APEAL++K Sbjct: 127 LHTLEPLIPRHALNSRSVMIDEDMTARIS---MADVKFSFQSPGRMYAPAWVAPEALQKK 183 Query: 362 KFSTK---SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYD 417 T +D+WSF +LLWE+ + VP+ + ++ +V +G + P G P V Sbjct: 184 PEDTNRRSADMWSFAVLLWELVT-REVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSK 242 Query: 418 VMKNCWHLDAATRPTFLQLREQLEHIR 444 +MK C + D A RP F + LE ++ Sbjct: 243 LMKICMNEDPAKRPKFDMIVPILEKMQ 269 >3Q4U-A nrPDB Length = 301 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 80/296 (27%), Positives = 136/296 (45%), Gaps = 48/296 (16%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFL-AEASVMTQLRHSNLVQL 251 +++ LL+ +GKG +G+V G ++G VAVK + F E LRH N++ Sbjct: 8 RDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 67 Query: 252 LGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 + + + L+++T Y GSL DYL+ + L L+ L + + +L Sbjct: 68 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQ---LTTLDTVSCLRIVLSIASGLAHLHIE 124 Query: 309 NF--------VHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLP----VKWT 353 F HRDL ++N+LV ++ ++D GL ++++ D G P ++ Sbjct: 125 IFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYM 184 Query: 354 APEALREKK----FST--KSDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPR---VE 400 APE L E F + + D+W+FG++LWE+ S G V + P DVVP E Sbjct: 185 APEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFE 244 Query: 401 KGYKMDAPDGCPPAVYD-------------VMKNCWHLDAATRPTFLQLREQLEHI 443 K+ D P + + +MK CW+ + + R T L++++ L I Sbjct: 245 DMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 300 >6AMW-A nrPDB Length = 255 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 56/157 (35%), Positives = 83/157 (52%), Gaps = 8/157 (5%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74 +A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ Sbjct: 86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWAEAQTKNG-QGWVPSNYITPV------ 138 Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH 134 L W+HG ++R AE LL G FLVRES + PG ++ + EG+V HYRI Sbjct: 139 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 198 Query: 135 A-SKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 + KL + E F L +LV H++T ADGL T L P Sbjct: 199 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP 235 >2ABL-A nrPDB Length = 163 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 55/157 (35%), Positives = 85/157 (54%), Gaps = 8/157 (5%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74 +A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ ++ Sbjct: 12 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITPVNSLEKH 70 Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH 134 + W+HG ++R AE LL G FLVRES + PG ++ + EG+V HYRI Sbjct: 71 S------WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 124 Query: 135 A-SKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 + KL + E F L +LV H++T ADGL T L P Sbjct: 125 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP 161 >5XD6-A nrPDB Length = 305 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 74/207 (35%), Positives = 110/207 (53%), Gaps = 27/207 (13%) Query: 201 IGKGEFGDVMLGDYRGNKVAV--KCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE 258 IG+G +G V G + K A K + Q FLA+ S++++LR N+V LLG V+ Sbjct: 30 IGEGSYGRVFYGILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVALLGYCVD- 88 Query: 259 KGGLYIVT-EYMAKGSLVDYLRSRGRSVLG---GDCL-----LKFSLDVCEAMEYLE--- 306 G L ++ EY GSL D L R + V G G L +K ++ +EYL Sbjct: 89 -GPLRVLAYEYAPNGSLHDILHGR-KGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKA 146 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS-------STQDTGKLPVKWTAPEALR 359 + +HRD+ + NVL+ +D+VAK++DF L+ +A ST+ G + APE Sbjct: 147 NPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTF--GYHAPEYAM 204 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVP 386 STKSDV+SFG++L E+ + GR P Sbjct: 205 TGTLSTKSDVYSFGVVLLELLT-GRKP 230 >6CTH-A nrPDB Length = 309 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 83/267 (31%), Positives = 133/267 (49%), Gaps = 29/267 (10%) Query: 201 IGKGEFGDVMLGDYRGNK--VAVKCIKNDATA--QAFLAEASVMTQLRHSNLVQLLGVIV 256 +G+G FG V G R + +AVK + + + + +E ++++LRH NLV+L+G Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHKNLVKLIG-WC 81 Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL--EGNNFV-HR 313 E+G L +V E+MA GSL ++ +G+S+L + + D+ A+ YL EG++ V HR Sbjct: 82 HERGELMLVYEFMANGSLDSHI-FKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCVLHR 140 Query: 314 DLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL----PVKWTAPEALREKKFSTKSDV 369 D+ N+++ AK+ DFGL + + K V + APE L K S +SDV Sbjct: 141 DIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKASKESDV 200 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKD---VVPRVEKGYK----MDAPDGCPPAVYD----- 417 +SFG++ EI S R P+ + +VP V + Y +D D +D Sbjct: 201 YSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKLGMAFDPKQLE 260 Query: 418 --VMKNCW--HLDAATRPTFLQLREQL 440 VM W H RP+ Q+ + L Sbjct: 261 CLVMVGLWCAHPSHNLRPSIRQVIQVL 287 >3MY0-A nrPDB Length = 305 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 80/297 (26%), Positives = 135/297 (45%), Gaps = 50/297 (16%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQ--LRHSNLVQ 250 +++ L++ +GKG +G+V G + G VAVK I + Q++ E + LRH N++ Sbjct: 8 RQVALVECVGKGRYGEVWRGLWHGESVAVK-IFSSRDEQSWFRETEIYNTVLLRHDNILG 66 Query: 251 LLGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 + + + L+++T Y GSL D+L+ R L L+ ++ + +L Sbjct: 67 FIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ---RQTLEPHLALRLAVSAACGLAHLHV 123 Query: 308 NNF--------VHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTGKLP----VKW 352 F HRD +RNVLV + ++D GL + S D G P ++ Sbjct: 124 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 183 Query: 353 TAPEALREK------KFSTKSDVWSFGILLWEIYSF----GRVPYPRIPLKDVVPR---V 399 APE L E+ + +D+W+FG++LWEI G V R P DVVP Sbjct: 184 MAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSF 243 Query: 400 EKGYKMDAPDGCPPAVYD-------------VMKNCWHLDAATRPTFLQLREQLEHI 443 E K+ D P + + +M+ CW+ + + R T L++++ L+ I Sbjct: 244 EDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 300 >4CZT-A nrPDB Length = 464 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 76/262 (29%), Positives = 124/262 (47%), Gaps = 28/262 (10%) Query: 196 KLLQTIGKGEFGDVMLGDY--RGNKVAVKCI------KNDATAQAFLAEASVMTQLRHSN 247 +L +T+G+G F V G+ VA+K I KN AQ E S M ++H N Sbjct: 14 ELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQ-IKREISTMKLIKHPN 72 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 ++++ V+ K +Y V E++ G L D + S GR L D K+ + A++Y Sbjct: 73 VIRMFEVMAS-KTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYCHS 129 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV-----KWTAPEALREKK 362 HRDL N+L+ + KVSDFGL+ ++ G L + APE + K Sbjct: 130 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 363 F-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPP----AVYD 417 + K+D+WS G++L+ + + G +P+ L + ++ K A CPP + Sbjct: 190 YDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK-----AEFTCPPWFSASAKK 243 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++K + ATR TF ++ E Sbjct: 244 LIKRILDPNPATRITFAEVIEN 265 >5UIU-A nrPDB Length = 323 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 82/269 (30%), Positives = 124/269 (46%), Gaps = 29/269 (10%) Query: 201 IGKGEFGDVMLGDYRGNKVAVKC------IKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 +G+G FG V G VAVK I + Q F E VM + +H NLV+LLG Sbjct: 55 MGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG- 113 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRS-RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 + L +V YM GSL+D L G L K + + +L N+ +HR Sbjct: 114 FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHR 173 Query: 314 DLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKL--PVKWTAPEALREKKFSTKSD 368 D+ + N+L+ E AK+SDFGL + + + T T ++ + APEALR + + KSD Sbjct: 174 DIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITPKSD 232 Query: 369 VWSFGILLWEIYS-FGRVPYPRIP-------------LKDVVPRVEKGYKMDAPDGCPPA 414 ++SFG++L EI + V R P K + ++K DA A Sbjct: 233 IYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMN-DADSTSVEA 291 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +Y V C H RP ++++ L+ + Sbjct: 292 MYSVASQCLHEKKNKRPDIKKVQQLLQEM 320 >3DAK-A nrPDB Length = 290 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 76/279 (27%), Positives = 132/279 (47%), Gaps = 33/279 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDY---RGNKVAVKCI---KNDATAQAFLAEASVMT 241 W++N + +L + IG G V+ Y + KVA+K I K + L E M+ Sbjct: 5 WSINRDDYELQEVIGSGATA-VVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMS 63 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR---SRGR---SVLGGDCLLKFS 295 Q H N+V V K L++V + ++ GS++D ++ ++G VL + Sbjct: 64 QCHHPNIVSYYTSFVV-KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATIL 122 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---- 351 +V E +EYL N +HRD+ A N+L+ ED +++DFG++ ++ D + V+ Sbjct: 123 REVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFV 182 Query: 352 ----WTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIP--------LKDVVPR 398 W APE + + + + K+D+WSFGI E+ + G PY + P L++ P Sbjct: 183 GTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPS 241 Query: 399 VEKGYK-MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 +E G + + + ++ C D RPT +L Sbjct: 242 LETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAEL 280 >4APC-A nrPDB Length = 350 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 104/198 (52%), Gaps = 10/198 (5%) Query: 191 NMKELKLLQTIGKGEFGDVML--GDYRGNKVAVKCIK----NDATAQAFLAEASVMTQLR 244 +M++ LQ IG+G FG +L G + +K I + + E +V+ ++ Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMK 81 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H N+VQ EE G LYIV +Y G L + ++ + D +L + + +C A+++ Sbjct: 82 HPNIVQYRESF-EENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKH 140 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREK 361 + +HRD+ ++N+ +++D ++ DFG+ + +ST + + + + +PE K Sbjct: 141 VHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENK 200 Query: 362 KFSTKSDVWSFGILLWEI 379 ++ KSD+W+ G +L+E+ Sbjct: 201 PYNNKSDIWALGCVLYEL 218 >5DBX-A nrPDB Length = 328 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 78/279 (27%), Positives = 130/279 (46%), Gaps = 31/279 (11%) Query: 187 GWALNMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCI---KNDATAQAFLAEASVMT 241 GW + +L + IG G V L R +VA+K I K + L E M+ Sbjct: 5 GWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMS 64 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD---YLRSRGR---SVLGGDCLLKFS 295 Q H N+V V K L++V + ++ GS++D Y+ +RG VL + Sbjct: 65 QCSHPNVVTYYTSFVV-KDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIL 123 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---- 351 +V E ++YL N +HRDL A N+L+ ED +++DFG++ ++ D + V+ Sbjct: 124 KEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFV 183 Query: 352 ----WTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIP--------LKDVVPR 398 W APE + + + + K+D+WSFGI E+ + G PY + P L++ P Sbjct: 184 GTPCWMAPEVMEQVRGYDFKADMWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPT 242 Query: 399 VEKGYK-MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 +E G + + + ++ C D + RPT +L Sbjct: 243 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAEL 281 >3DXN-A nrPDB Length = 287 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 75/229 (32%), Positives = 118/229 (51%), Gaps = 26/229 (11%) Query: 198 LQTIGKGEFGDVML--GDYRGNKVAVKCIKNDA-----TAQAFLAEASVMTQLRHSNLVQ 250 ++ +G G +G+V+L G + A+K IK + + A L E +V+ QL H N+++ Sbjct: 26 VKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMK 85 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAMEYLEGNN 309 L E+K Y+V E G L D + R + S + ++K V YL +N Sbjct: 86 LYEFF-EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMK---QVLSGTTYLHKHN 141 Query: 310 FVHRDLAARNVLV---SEDNVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPEALREK 361 VHRDL N+L+ S D + K+ DFGL+ + + GK+ + + APE LR K Sbjct: 142 IVHRDLKPENLLLESKSRDALIKIVDFGLS---AHFEVGGKMKERLGTAYYIAPEVLR-K 197 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPD 409 K+ K DVWS G++L+ I G P+ ++++ RVEKG + D PD Sbjct: 198 KYDEKCDVWSCGVILY-ILLCGYPPFGGQTDQEILKRVEKGKFSFDPPD 245 >3HZT-A nrPDB Length = 467 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 75/229 (32%), Positives = 118/229 (51%), Gaps = 26/229 (11%) Query: 198 LQTIGKGEFGDVML--GDYRGNKVAVKCIKNDA-----TAQAFLAEASVMTQLRHSNLVQ 250 ++ +G G +G+V+L G + A+K IK + + A L E +V+ QL H N+++ Sbjct: 9 VKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMK 68 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAMEYLEGNN 309 L E+K Y+V E G L D + R + S + ++K V YL +N Sbjct: 69 LYEFF-EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMK---QVLSGTTYLHKHN 124 Query: 310 FVHRDLAARNVLV---SEDNVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPEALREK 361 VHRDL N+L+ S D + K+ DFGL+ + + GK+ + + APE LR K Sbjct: 125 IVHRDLKPENLLLESKSRDALIKIVDFGLS---AHFEVGGKMKERLGTAYYIAPEVLR-K 180 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPD 409 K+ K DVWS G++L+ I G P+ ++++ RVEKG + D PD Sbjct: 181 KYDEKCDVWSCGVILY-ILLCGYPPFGGQTDQEILKRVEKGKFSFDPPD 228 >4CQG-A nrPDB Length = 331 Score = 91.3 bits (225), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 73/263 (27%), Positives = 124/263 (47%), Gaps = 22/263 (8%) Query: 192 MKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAF---LAEASVMTQLRHS 246 +K +L +TIG G F V L + G VA+K + +A E + LRH Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQ 67 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 ++ QL V+ E K +++V EY G L DY+ S+ R L + + A+ Y+ Sbjct: 68 HICQLYHVL-ETKNKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQILSAVAYVH 124 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPVKWTAPEALRE 360 + HRDL N+L E++ K+ DFGL + +D G L + APE ++ Sbjct: 125 SQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLA--YAAPELIQG 182 Query: 361 KKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 K + +++DVWS GILL+ + G +P+ + + ++ +G K + P P+ ++ Sbjct: 183 KSYLGSEADVWSMGILLY-VLMCGFLPFDDDNVMALYKKIMRG-KYEVPKWLSPSSILLL 240 Query: 420 KNCWHLDAATRPTFLQLREQLEH 442 + +D R + +R L H Sbjct: 241 QQMLQVDPKKR---ISMRNLLNH 260 >3COM-A nrPDB Length = 314 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 107/205 (52%), Gaps = 9/205 (4%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 +L+ +G+G +G V ++ G VA+K + ++ Q + E S+M Q ++V+ G Sbjct: 33 VLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGS 92 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + L+IV EY GS+ D +R R ++ L D + + +EYL +HRD Sbjct: 93 YFKNTD-LWIVMEYCGAGSVSDIIRLRNKT-LTEDEIATILQSTLKGLEYLHFMRKIHRD 150 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDVWS 371 + A N+L++ + AK++DFG+ + + T + W APE ++E ++ +D+WS Sbjct: 151 IKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWS 210 Query: 372 FGILLWEIYSFGRVPYPRI-PLKDV 395 GI E+ G+ PY I P++ + Sbjct: 211 LGITAIEMAE-GKPPYADIHPMRAI 234 >3MA6-A nrPDB Length = 298 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 76/240 (31%), Positives = 116/240 (48%), Gaps = 20/240 (8%) Query: 183 FYRSGWALNMKELKLLQTIGKGEFGDVML--GDYRGNKVAVKCI-----KNDATAQAFLA 235 F + A+ K + +GKG FG+V+L G + AVK I K ++ L Sbjct: 22 FVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLR 81 Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKF 294 E ++ QL H N+++L E+KG Y+V E G L D + SR R S + +++ Sbjct: 82 EVQLLKQLDHPNIMKLYEFF-EDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIR- 139 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTK--EASSTQDTGKLP 349 V + Y+ N VHRDL N+L+ S+D ++ DFGL+ EAS Sbjct: 140 --QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGT 197 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP 408 + APE L + K DVWS G++L+ + S G P+ D++ +VEKG Y + P Sbjct: 198 AYYIAPEVL-HGTYDEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELP 255 >4WNO-A nrPDB Length = 287 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/205 (31%), Positives = 98/205 (47%), Gaps = 23/205 (11%) Query: 201 IGKGEFGDVMLGDYRGN---KVAVKCI--KNDATAQAFLA-EASVMTQLRHSNLVQLLGV 254 IG G F V G +R +VAVKCI KN A +Q L E ++ +L+H N+V L Sbjct: 26 IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYD- 84 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 E +Y+V EY G L DYL + L D + F + AM L +HRD Sbjct: 85 FQEMANSVYLVMEYCNGGDLADYLHAM--RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRD 142 Query: 315 LAARNVLVSEDN---------VAKVSDFGLTKEASSTQDTGKL---PVKWTAPEALREKK 362 L +N+L+S K++DFG + S L P+ + APE + + Sbjct: 143 LKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPM-YMAPEVIMSQH 201 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPY 387 + K+D+WS G ++++ + G+ P+ Sbjct: 202 YDGKADLWSIGTIVYQCLT-GKAPF 225 >6J5U-C nrPDB Length = 426 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 70/214 (32%), Positives = 106/214 (49%), Gaps = 23/214 (10%) Query: 193 KELKLLQTIGKGEFGDVMLG-----------DYRGNKVAVKCIKNDATA--QAFLAEASV 239 K + +G+G FG V G G VAVK +K + + +L E + Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVNY 143 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 + QL H NLV L+G E + L +V E+M KGSL ++L RG L +K ++ Sbjct: 144 LGQLSHPNLVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAA 202 Query: 300 EAMEYLE--GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK------ 351 + + +L + ++RD A N+L+ D AK+SDFGL K A T D + K Sbjct: 203 KGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAK-AGPTGDNTHVSTKVIGTHG 261 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV 385 + APE + + + KSDV+SFG++L E+ S R Sbjct: 262 YAAPEYVATGRLTAKSDVYSFGVVLLELISGRRA 295 >4LG4-A nrPDB Length = 299 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 111/207 (53%), Gaps = 13/207 (6%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 +L+ +G+G +G V ++ G VA+K + ++ Q + E S+M Q +V+ G Sbjct: 15 VLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGS 74 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD--CLLKFSLDVCEAMEYLEGNNFVH 312 + L+IV EY GS+ D +R R ++++ + +LK +L + +EYL +H Sbjct: 75 YFKNTD-LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL---KGLEYLHFMRKIH 130 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDV 369 R++ A N+L++ + AK++DFG+ + + T + W APE ++E ++ +D+ Sbjct: 131 RNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 190 Query: 370 WSFGILLWEIYSFGRVPYPRI-PLKDV 395 WS GI E+ G+ PY I P++ + Sbjct: 191 WSLGITSIEMAE-GKPPYADIHPMRAI 216 >5JN2-A nrPDB Length = 525 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 76/240 (31%), Positives = 116/240 (48%), Gaps = 20/240 (8%) Query: 183 FYRSGWALNMKELKLLQTIGKGEFGDVML--GDYRGNKVAVKCI-----KNDATAQAFLA 235 F + A+ K + +GKG FG+V+L G + AVK I K ++ L Sbjct: 57 FVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLR 116 Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKF 294 E ++ QL H N+++L E+KG Y+V E G L D + SR R S + +++ Sbjct: 117 EVQLLKQLDHPNIMKLYEFF-EDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIR- 174 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTK--EASSTQDTGKLP 349 V + Y+ N VHRDL N+L+ S+D ++ DFGL+ EAS Sbjct: 175 --QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGT 232 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP 408 + APE L + K DVWS G++L+ + S G P+ D++ +VEKG Y + P Sbjct: 233 AYYIAPEVLH-GTYDEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELP 290 >6AO5-A nrPDB Length = 362 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 70/256 (27%), Positives = 127/256 (49%), Gaps = 19/256 (7%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 +L+ +G+G +G V ++ G VA+K + ++ Q + E S+M Q +V+ G Sbjct: 14 VLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGS 73 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD--CLLKFSLDVCEAMEYLEGNNFVH 312 + L+IV EY GS+ D +R R ++++ + +LK +L + +EYL +H Sbjct: 74 YFK-NTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL---KGLEYLHFMRKIH 129 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDV 369 R++ A N+L++ + AK++DFG+ + + T + W APE ++E ++ +D+ Sbjct: 130 RNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 189 Query: 370 WSFGILLWEIYSFGRVPYPRI-PLKDV--VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 WS GI E+ G+ PY I P++ + +P P+ D +K C + Sbjct: 190 WSLGITSIEMAE-GKPPYADIHPMRAIFMIP-TNPPPTFRKPELWSDDFTDFVKKCLVKN 247 Query: 427 AATRPTFLQLREQLEH 442 R T QL L+H Sbjct: 248 PEQRATATQL---LQH 260 >1FOT-A nrPDB Length = 318 Score = 88.2 bits (217), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 52/204 (25%), Positives = 104/204 (50%), Gaps = 11/204 (5%) Query: 191 NMKELKLLQTIGKGEFGDVML--GDYRGNKVAVKCIKNDATAQAFLAEAS-----VMTQL 243 ++++ ++L+T+G G FG V L + G A+K +K + + E + +++ + Sbjct: 4 SLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV 63 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H ++++ G ++ ++++ +Y+ G L LR R ++ +VC A+E Sbjct: 64 THPFIIRMWGTF-QDAQQIFMIMDYIEGGELFSLLRKSQR--FPNPVAKFYAAEVCLALE 120 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 YL + ++RDL N+L+ ++ K++DFG K T + APE + K + Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPY 180 Query: 364 STKSDVWSFGILLWEIYSFGRVPY 387 + D WSFGIL++E+ + G P+ Sbjct: 181 NKSIDWWSFGILIYEMLA-GYTPF 203 >6QAU-A nrPDB Length = 280 Score = 88.2 bits (217), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 101/205 (49%), Gaps = 23/205 (11%) Query: 201 IGKGEFGDVMLGDYRGN---KVAVKCI--KNDATAQAFLA-EASVMTQLRHSNLVQLLGV 254 +G G F V G +R +VA+K I KN + +Q L E ++ +L+H N+V L V Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDV 78 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 E +++V EY G L DYL+++G L D + F + AM L +HRD Sbjct: 79 -QELPNSVFLVMEYCNGGDLADYLQAKG--TLSEDTIRVFLHQIAAAMRILHSKGIIHRD 135 Query: 315 LAARNVLVSEDN---------VAKVSDFGLTKEASSTQDTGKL---PVKWTAPEALREKK 362 L +N+L+S N K++DFG + S L P+ + APE + + Sbjct: 136 LKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPM-YMAPEVIMSQH 194 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPY 387 + K+D+WS G ++++ G+ P+ Sbjct: 195 YDAKADLWSIGTVIYQCL-VGKPPF 218 >3LIJ-A nrPDB Length = 494 Score = 87.8 bits (216), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 75/263 (28%), Positives = 132/263 (50%), Gaps = 30/263 (11%) Query: 198 LQTIGKGEFGDVMLGDYRGNKV--AVKCIKNDATAQA----FLAEASVMTQLRHSNLVQL 251 ++ +G G +G+V+L + V A+K I+ + + + L E +V+ L H N+++L Sbjct: 42 VKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKL 101 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAMEYLEGNNF 310 E+K Y+V E G L D + R + + + ++K V + YL +N Sbjct: 102 YDFF-EDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIK---QVLSGVTYLHKHNI 157 Query: 311 VHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPEALREKK 362 VHRDL N+L+ +D + K+ DFGL+ + ++ K+ + + APE LR KK Sbjct: 158 VHRDLKPENLLLESKEKDALIKIVDFGLS---AVFENQKKMKERLGTAYYIAPEVLR-KK 213 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPD--GCPPAVYDVM 419 + K DVWS G++L+ I G P+ ++++ +VEKG Y D+P+ D++ Sbjct: 214 YDEKCDVWSIGVILF-ILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLI 272 Query: 420 KNCWHLDAATRPTFLQLREQLEH 442 K D+ R + ++ LEH Sbjct: 273 KQMLQFDSQRR---ISAQQALEH 292 >4QMW-A nrPDB Length = 310 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 69/253 (27%), Positives = 124/253 (49%), Gaps = 16/253 (6%) Query: 198 LQTIGKGEFGDVMLG-DYRGNKV-AVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLL 252 L+ IGKG FG+V G D R KV A+K I + + + E +V++Q + + Sbjct: 34 LEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYY 93 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 G +++ L+I+ EY+ GS +D L +L+ ++ + ++YL +H Sbjct: 94 GSYLKDTK-LWIIMEYLGGGSALDLLEPGPLDETQIATILR---EILKGLDYLHSEKKIH 149 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDV 369 RD+ A NVL+SE K++DFG+ + + TQ V W APE +++ + +K+D+ Sbjct: 150 RDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADI 209 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAAT 429 WS GI E+ + G P+ + V+ + K + + ++ C + + + Sbjct: 210 WSLGITAIEL-ARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSF 268 Query: 430 RPTFLQLREQLEH 442 RPT +E L+H Sbjct: 269 RPT---AKELLKH 278 >4EQM-A nrPDB Length = 294 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/268 (27%), Positives = 127/268 (47%), Gaps = 28/268 (10%) Query: 196 KLLQTIGKGEFGDVMLGD--YRGNKVAVKCI-----KNDATAQAFLAEASVMTQLRHSNL 248 K++ +G G V L + KVA+K I + + T + F E +QL H N+ Sbjct: 14 KIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQNI 73 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 V ++ V EE Y+V EY+ +L +Y+ S G L D + F+ + + +++ Sbjct: 74 VSMIDV-DEEDDCYYLVMEYIEGPTLSEYIESHGP--LSVDTAINFTNQILDGIKHAHDM 130 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTK---EASSTQDTGKL-PVKWTAPEALREKKFS 364 VHRD+ +N+L+ + K+ DFG+ K E S TQ L V++ +PE + + Sbjct: 131 RIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATD 190 Query: 365 TKSDVWSFGILLWEIYSFGRVPYP-----RIPLK---DVVPRVEKGYKMDAPDGCPPAVY 416 +D++S GI+L+E+ G P+ I +K D VP V + D P ++ Sbjct: 191 ECTDIYSIGIVLYEML-VGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKD----IPQSLS 245 Query: 417 DVMKNCWHLDAATR-PTFLQLREQLEHI 443 +V+ D A R T ++++ L + Sbjct: 246 NVILRATEKDKANRYKTIQEMKDDLSSV 273 >5WNL-A nrPDB Length = 342 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/287 (27%), Positives = 124/287 (43%), Gaps = 34/287 (11%) Query: 185 RSGWALNM------KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK----NDATAQA 232 R WAL + E + +G G FG V + K +A+KC +D Sbjct: 6 RGRWALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERME 65 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 L EA M + ++ + G+ E G +V EYM GSL L S L D Sbjct: 66 LLEEAKKMEMAKFRYILPVYGICQEPVG---LVMEYMETGSLEKLLASEP---LPWDLRF 119 Query: 293 KFSLDVCEAMEYLE--GNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDTGKL 348 + + M +L +H +L N+L+ K+SDFGL K S + D Sbjct: 120 RIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMD 179 Query: 349 ----PVKWTAPEALREKK--FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 + + PE +REK F TK DV+SF I++W + + + + ++ +V KG Sbjct: 180 GLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKG 239 Query: 403 YKMDAPDGCPP------AVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 ++ + P C P ++ +M+ CWH D RPTF ++ + E + Sbjct: 240 HRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDL 286 >4D2V-A nrPDB Length = 356 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/257 (27%), Positives = 118/257 (45%), Gaps = 19/257 (7%) Query: 192 MKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAF---LAEASVMTQLRHS 246 +K +L +TIG G F V L + G VA+K + + E + LRH Sbjct: 28 LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQ 87 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 ++ QL V+ E +++V EY G L DY+ S+ R L + + A+ Y+ Sbjct: 88 HICQLYHVL-ETANKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQIVSAVAYVH 144 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPVKWTAPEALRE 360 + HRDL N+L E + K+ DFGL + +D G L + APE ++ Sbjct: 145 SQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALA--YAAPELIQG 202 Query: 361 KKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 K + +++DVWS GILL+ + G +P+ +V ++ +G K D P P+ ++ Sbjct: 203 KSYLGSEADVWSMGILLY-VLMCGFLPFDDDTAAALVAKIMRG-KYDVPKWLSPSSILLL 260 Query: 420 KNCWHLDAATRPTFLQL 436 + +D R + L Sbjct: 261 QQMLQVDPKKRISMKNL 277 >4RGJ-A nrPDB Length = 520 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 76/277 (27%), Positives = 130/277 (46%), Gaps = 26/277 (9%) Query: 183 FYRSGWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCI-----KNDATAQAFLA 235 F ++ + ++ K ++ +GKG FG+V+L + G++ A+K I K ++ L Sbjct: 50 FIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLR 109 Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKF 294 E ++ L H N+++L E+ Y+V++ G L D + SR R + ++K Sbjct: 110 EVELLKMLDHINIMKLYEFF-EDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIK- 167 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLV----SEDNVAKVSDFGLTK--EASSTQDTGKL 348 + + Y+ NN VHRDL N+L+ ED + K+ DFGL+ E S Sbjct: 168 --QILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIG 225 Query: 349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDA 407 + AP+ L + K D+WS G++L+ + S G P+ D++ +VE G Y D Sbjct: 226 TAYYIAPDVLH-GTYDEKCDIWSCGVILYILLS-GCPPFNGSNEYDILKKVEAGKYTFDL 283 Query: 408 PD--GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 P D++K +A R + R+ LEH Sbjct: 284 PQFKKISDKAKDLIKKMLMYTSAVR---ISARDALEH 317 >4FZF-B nrPDB Length = 283 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 73/254 (28%), Positives = 123/254 (48%), Gaps = 18/254 (7%) Query: 198 LQTIGKGEFGDVMLG-DYRGNKV-AVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLL 252 L+ IGKG FG+V G D R +V A+K I + + + E +V++Q S + + Sbjct: 13 LERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYY 72 Query: 253 GVIVEEKGG-LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 G + KG L+I+ EY+ GS +D LR+ +LK ++ + ++YL + Sbjct: 73 GSYL--KGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLK---EILKGLDYLHSEKKI 127 Query: 312 HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSD 368 HRD+ A NVL+SE K++ FG+ + + TQ V W APE +++ + +K+D Sbjct: 128 HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKAD 187 Query: 369 VWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAA 428 +WS GI E+ G P + V+ + K + + + C + D + Sbjct: 188 IWSLGITAIELAK-GEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPS 246 Query: 429 TRPTFLQLREQLEH 442 RPT +E L+H Sbjct: 247 FRPT---AKELLKH 257 >5TOS-A nrPDB Length = 395 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 34/228 (14%) Query: 189 ALNMKELKLL-------QTIGKGEFGDVMLG-----------DYRGNKVAVKCIKNDATA 230 + ELKL IG+G FG V G G +AVK + + Sbjct: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 Query: 231 --QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 + +L E + + QL H NLV+L+G +E++ L +V E+M KGSL ++L RG Sbjct: 114 GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPL 172 Query: 289 DCLLKF--SLDVCEAMEYLEGN--NFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---- 340 L+ +LD + + +L + ++RD+ A N+L+ D AK+SDFGL ++ Sbjct: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 Query: 341 ---STQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV 385 ST+ G + APE + + +SDV+SFG+LL EI S R Sbjct: 233 SYVSTRVMGT--YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRA 278 >4L00-A nrPDB Length = 304 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 65/213 (30%), Positives = 99/213 (46%), Gaps = 19/213 (8%) Query: 232 AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCL 291 AF AS+M Q+ H ++V L GV V + I+ E +G +D R VL Sbjct: 78 AFFEAASMMRQVSHKHIVYLYGVCVRDVEN--IMVEEFVEGGPLDLFMHRKSDVLTTPWK 135 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV-------AKVSDFGLTKEASSTQD 344 K + + A+ YLE + VH ++ +N+L++ + + K+SD G+ S Q+ Sbjct: 136 FKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQE 195 Query: 345 TGKLPVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD-VVPRVEKG 402 + + W APE + + K S +D WSFG LWEI G IPLKD + E+ Sbjct: 196 CIER-IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNG-----EIPLKDKTLIEKERF 249 Query: 403 YKMDAPDGCPPA--VYDVMKNCWHLDAATRPTF 433 Y+ P + D+M C + D RP F Sbjct: 250 YESRCRPVTPSCKELADLMTRCMNYDPNQRPFF 282 >4FG9-A nrPDB Length = 320 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 74/246 (30%), Positives = 118/246 (47%), Gaps = 17/246 (6%) Query: 200 TIGKGEFGDVMLG-DYRGNK-VAVKCIKNDA---TAQAFLAEASVMTQLRHSNLVQLLGV 254 +G G F +V+L D R K VA+KCI +A + E +V+ +++H N+V L Sbjct: 25 VLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVAL-DD 83 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 I E G LY++ + ++ G L D + +G L F V +A++YL VHRD Sbjct: 84 IYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQ--VLDAVKYLHDLGIVHRD 141 Query: 315 LAARNVL---VSEDNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALREKKFSTKSDV 369 L N+L + ED+ +SDFGL+K + S T + APE L +K +S D Sbjct: 142 LKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDC 201 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYDVMKNCWHLD 426 WS G++ + I G P+ + ++ K Y+ D+P D + D +++ D Sbjct: 202 WSIGVIAY-ILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKD 260 Query: 427 AATRPT 432 R T Sbjct: 261 PEKRFT 266 >3ALO-A nrPDB Length = 327 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 78/281 (27%), Positives = 133/281 (47%), Gaps = 37/281 (13%) Query: 188 WALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIK---NDATAQAFLAEASVMTQ 242 W ++LK L IG+G +G V M+ G +AVK I+ ++ + L + V+ Sbjct: 17 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVV-- 74 Query: 243 LRHSN---LVQLLGVIVEEKGGLYIVTEYMAKG--SLVDYLRSRGRSVLGGDCLLKFSLD 297 +R S+ +VQ G + E G +I E M+ Y+ S V+ + L K +L Sbjct: 75 MRSSDCPYIVQFYGALFRE-GDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLA 133 Query: 298 VCEAMEYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFGLTKE----ASSTQDTGKLPVKW 352 +A+ +L+ N +HRD+ N+L+ K+ DFG++ + + T+D G P + Sbjct: 134 TVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP--Y 191 Query: 353 TAPEAL----REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP 408 APE + + + +SDVWS GI L+E+ + GR PYP+ V ++ + K D P Sbjct: 192 MAPERIDPSASRQGYDVRSDVWSLGITLYELAT-GRFPYPK--WNSVFDQLTQVVKGDPP 248 Query: 409 D-------GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 P+ + + C D + RP + +E L+H Sbjct: 249 QLSNSEEREFSPSFINFVNLCLTKDESKRPKY---KELLKH 286 >5F9E-A nrPDB Length = 353 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 105/209 (50%), Gaps = 15/209 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-----AQAFLAEASVMTQ 242 L +++ +L + +GKG FG V L +++ A+K +K D + + E V++ Sbjct: 16 LKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL 75 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + + + K L+ V EY+ G L+ +++S + L ++ ++ + Sbjct: 76 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATF--YAAEIILGL 133 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA----SSTQDTGKLPVKWTAPEAL 358 ++L V+RDL N+L+ +D K++DFG+ KE + T + P + APE L Sbjct: 134 QFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTP-DYIAPEIL 192 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPY 387 +K++ D WSFG+LL+E+ G+ P+ Sbjct: 193 LGQKYNHSVDWWSFGVLLYEML-IGQSPF 220 >4CFH-A nrPDB Length = 493 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 67/250 (26%), Positives = 117/250 (46%), Gaps = 15/250 (6%) Query: 200 TIGKGEFGDVMLGDYR--GNKVAVKC-----IKNDATAQAFLAEASVMTQLRHSNLVQLL 252 T+G G FG V +G + G+KVAVK I++ E + RH ++++L Sbjct: 40 TLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 99 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 VI +++V EY++ G L DY+ GR L + + ++Y + VH Sbjct: 100 QVI-STPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVDYCHRHMVVH 156 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKFS-TKSDV 369 RDL NVL+ AK++DFGL+ S + T + APE + + ++ + D+ Sbjct: 157 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 216 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAAT 429 WS G++L+ + G +P+ + + ++ G P P+V ++K+ +D Sbjct: 217 WSSGVILYALLC-GTLPFDDDHVPTLFKKICDGI-FYTPQYLNPSVISLLKHMLQVDPMK 274 Query: 430 RPTFLQLREQ 439 R T +RE Sbjct: 275 RATIKDIREH 284 >2JAM-A nrPDB Length = 304 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 104/219 (47%), Gaps = 12/219 (5%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ--AFLAEASVMTQLRHSNL 248 K ++ +G G F +V L R G A+KCIK + + E +V+ +++H N+ Sbjct: 9 KTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENI 68 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 V L I E Y+V + ++ G L D + RG L+ V A++YL N Sbjct: 69 VTLED-IYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLV--IQQVLSAVKYLHEN 125 Query: 309 NFVHRDLAARNVLV---SEDNVAKVSDFGLTK-EASSTQDTGKLPVKWTAPEALREKKFS 364 VHRDL N+L E++ ++DFGL+K E + T + APE L +K +S Sbjct: 126 GIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYS 185 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY 403 D WS G++ + I G P+ + ++++GY Sbjct: 186 KAVDCWSIGVITY-ILLCGYPPFYEETESKLFEKIKEGY 223 >3ORZ-A nrPDB Length = 316 Score = 84.3 bits (207), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 62/250 (24%), Positives = 112/250 (44%), Gaps = 17/250 (6%) Query: 193 KELKLLQTIGKGEFGDVMLG-------DYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 245 ++ K + +G+G F V+L +Y + + I + E VM++L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 V+L ++ LY Y G L+ Y+R G C ++ ++ A+EYL Sbjct: 97 PFFVKLY-FCFQDDEKLYFGLSYAKNGELLKYIRKIGS--FDETCTRFYTAEIVSALEYL 153 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-----PVKWTAPEALRE 360 G +HRDL N+L++ED +++DFG K S + ++ +PE L E Sbjct: 154 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 213 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 K SD+W+ G +++++ + G P+ + ++ K + D P+ P D+++ Sbjct: 214 KSACKSSDLWALGCIIYQLVA-GLPPFRAGNEYLIFQKIIK-LEYDFPEKFFPKARDLVE 271 Query: 421 NCWHLDAATR 430 LDA R Sbjct: 272 KLLVLDATKR 281 >5X3F-B nrPDB Length = 393 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 64/263 (24%), Positives = 120/263 (45%), Gaps = 14/263 (5%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQLR 244 + + ++T+G G FG VML ++ GN A+K + + L E ++ + Sbjct: 83 LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 142 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 LV+L ++ LY+V EY+A G + +LR GR ++ + EY Sbjct: 143 FPFLVKL-EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEY 199 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFS 364 L + ++RDL N+L+ + +V+DFG K T ++ APE + K ++ Sbjct: 200 LHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYN 259 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWH 424 D W+ G+L++E+ + G P+ + ++ G K+ P + D+++N Sbjct: 260 KAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLLQ 317 Query: 425 LDAATRPTFLQLREQLEHIRTHE 447 +D R F L+ + I+ H+ Sbjct: 318 VDLTKR--FGNLKNGVNDIKNHK 338 >5USZ-A nrPDB Length = 289 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/275 (25%), Positives = 128/275 (46%), Gaps = 23/275 (8%) Query: 193 KELKLLQTIGKGEFGDVM------LGDY---RGNKVAVKCIK--NDATAQAFLAEASVMT 241 ++L +++G+G F + +GDY +V +K + + +++F AS+M+ Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMS 67 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +L H +LV GV V + +V E++ GSL YL+ + ++ + L+ + + A Sbjct: 68 KLSHKHLVLNYGVCVCGDENI-LVQEFVKFGSLDTYLK-KNKNCINILWKLEVAKQLAAA 125 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKWTA 354 M +LE N +H ++ A+N+L+ + K + K + LP + W Sbjct: 126 MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP 185 Query: 355 PEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPP 413 PE + K + +D WSFG LWEI S G P + + + E +++ AP Sbjct: 186 PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAEL 245 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHEL 448 A +++ NC + RP+F + L + T +L Sbjct: 246 A--NLINNCMDYEPDHRPSFRAIIRDLNSLFTPDL 278 >6FD3-A nrPDB Length = 300 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/255 (26%), Positives = 118/255 (46%), Gaps = 19/255 (7%) Query: 198 LQTIGKGEFGDV--MLGDYRGNKVAVK--CIKNDATAQAFLAEASVMTQLRHSNLVQLL- 252 + IG+G G V L G +VA+K ++ + + E VM + ++ N+V L Sbjct: 27 FEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLD 86 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 +V ++ L++V EY+A GSL D + + + + + +A+++L N +H Sbjct: 87 SYLVGDE--LWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVIH 141 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDV 369 RD+ + N+L+ D K++DFG + + Q V W APE + K + K D+ Sbjct: 142 RDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDI 201 Query: 370 WSFGILLWEIYSFGRVPY-PRIPLKDVVPRVEKGY-KMDAPDGCPPAVYDVMKNCWHLDA 427 WS GI+ E+ G PY PL+ + G ++ P+ D + C +D Sbjct: 202 WSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 260 Query: 428 ATRPTFLQLREQLEH 442 R + +E L+H Sbjct: 261 DRRGS---AKELLQH 272 >3Q53-A nrPDB Length = 306 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 112/244 (45%), Gaps = 18/244 (7%) Query: 198 LQTIGKGEFGDV--MLGDYRGNKVAVK--CIKNDATAQAFLAEASVMTQLRHSNLVQLLG 253 + IG+G G V + G +VA++ ++ + + E VM + ++ N+V L Sbjct: 26 FEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLD 85 Query: 254 --VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 ++ +E L++V EY+A GSL D + + + + + +A+E+L N + Sbjct: 86 SYLVGDE---LWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALEFLHSNQVI 139 Query: 312 HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSD 368 HRD+ + N+L+ D K++DFG + + Q V W APE + K + K D Sbjct: 140 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 199 Query: 369 VWSFGILLWEIYSFGRVPY-PRIPLKDVVPRVEKGY-KMDAPDGCPPAVYDVMKNCWHLD 426 +WS GI+ E+ G PY PL+ + G ++ P+ D + C +D Sbjct: 200 IWSLGIMAIEMIE-GEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMD 258 Query: 427 AATR 430 R Sbjct: 259 VEKR 262 >4UZD-A nrPDB Length = 287 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 65/265 (24%), Positives = 122/265 (46%), Gaps = 22/265 (8%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCI-----KNDATAQAFLAEASVM 240 WAL ++ ++ + +GKG+FG+V L + +K +A+K + + E + Sbjct: 5 WAL--EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 62 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + LRH N+++L G + +Y++ EY G++ Y + S + ++ Sbjct: 63 SHLRHPNILRLYGYF-HDATRVYLILEYAPLGTV--YRELQKLSKFDEQRTATYITELAN 119 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT---GKLPVKWTAPEA 357 A+ Y +HRD+ N+L+ K++DFG + A S++ T G L + PE Sbjct: 120 ALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTL--DYLPPEM 177 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 + + K D+WS G+L +E + G+ P+ ++ R+ + + PD D Sbjct: 178 IEGRMHDEKVDLWSLGVLCYE-FLVGKPPFEANTYQETYKRISR-VEFTFPDFVTEGARD 235 Query: 418 VMKNCWHLDAATRPTFLQLREQLEH 442 ++ + + RP LRE LEH Sbjct: 236 LISRLLKHNPSQRPM---LREVLEH 257 >2F57-A nrPDB Length = 317 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 105/229 (45%), Gaps = 24/229 (10%) Query: 201 IGKGEFGDVMLG--DYRGNKVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLG--V 254 IG+G G V + + G +VAVK ++ + E +M H N+V + + Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYL 112 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + +E L++V E++ G+L D + + + + + L V A+ YL +HRD Sbjct: 113 VGDE---LWVVMEFLEGGALTDIV---THTRMNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDVWS 371 + + ++L++ D K+SDFG + S K V W APE + + T+ D+WS Sbjct: 167 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWS 226 Query: 372 FGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 GI++ E+ G PY P + R+ D PP V D+ K Sbjct: 227 LGIMVIEMID-GEPPYFNEPPLQAMRRIR--------DSLPPRVKDLHK 266 >4WB7-A nrPDB Length = 405 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 63/264 (23%), Positives = 121/264 (45%), Gaps = 14/264 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQL 243 ++ + + ++T+G G FG VML ++ GN A+K + + L E ++ + Sbjct: 94 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 153 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 LV+L ++ LY+V EY+ G + +LR GR ++ + E Sbjct: 154 NFPFLVKL-EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFE 210 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 YL + ++RDL N+L+ + +V+DFG K T ++ APE + K + Sbjct: 211 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGY 270 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 + D W+ G+L++E+ + G P+ + ++ G K+ P + D+++N Sbjct: 271 NKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLL 328 Query: 424 HLDAATRPTFLQLREQLEHIRTHE 447 +D R F L+ + I+ H+ Sbjct: 329 QVDLTKR--FGNLKNGVNDIKNHK 350 >4D28-A nrPDB Length = 446 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 108/227 (47%), Gaps = 22/227 (9%) Query: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLA-----EASVMTQLRHSNLVQL 251 +TIG+G F V G+ VA+K + + + E S+M +RH N+V+L Sbjct: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 V+ K +YIV E++ G L D + +GR L D K+ + +A+ + Sbjct: 75 YEVLAS-KSKIYIVLEFVTGGELFDRIVHKGR--LKEDESRKYFQQLVDAVAHCHSKGVY 131 Query: 312 HRDLAARNVLVSEDNVAKVSDFGLT----KEASSTQDTGKLPVKWTAPEALREKKFS-TK 366 HRDL N+L+ + KVSDFGL+ + DT P + APE L + + + Sbjct: 132 HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTP-NYVAPEVLSGQGYDGSA 190 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPP 413 +D+WS G++L+ I + G +P+ L + ++ A CPP Sbjct: 191 ADIWSCGVILFVILA-GYLPFSETDLPGLYRKINA-----AEFDCPP 231 >3DFA-A nrPDB Length = 286 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 72/224 (32%), Positives = 108/224 (48%), Gaps = 25/224 (11%) Query: 201 IGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ-----AFLAEASVMTQLRHSNLVQLLG 253 +GKG FG+V+ R + AVK I N A+A+ L E ++ +L H N+++L Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVI-NKASAKNKDTSTILREVELLKKLDHPNIMKLFE 88 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 I+E+ YIV E G L D + R R + V + Y+ +N VHR Sbjct: 89 -ILEDSSSFYIVGELYTGGELFDEIIKRKR--FSEHDAARIIKQVFSGITYMHKHNIVHR 145 Query: 314 DLAARNVLV---SEDNVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPEALREKKFST 365 DL N+L+ +D K+ DFGL ++ Q K+ + + APE LR + Sbjct: 146 DLKPENILLESKEKDCDIKIIDFGL---STCFQQNTKMKDRIGTAYYIAPEVLR-GTYDE 201 Query: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP 408 K DVWS G++L+ + S G P+ D++ RVE G Y D P Sbjct: 202 KCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLP 244 >4REW-A nrPDB Length = 540 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 66/250 (26%), Positives = 117/250 (46%), Gaps = 15/250 (6%) Query: 200 TIGKGEFGDVMLGDYR--GNKVAVKC-----IKNDATAQAFLAEASVMTQLRHSNLVQLL 252 T+G G FG V +G + G+KVAVK I++ E + RH ++++L Sbjct: 13 TLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 72 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 VI +++V EY++ G L DY+ GR L + + ++Y + VH Sbjct: 73 QVI-STPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVDYCHRHMVVH 129 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKFS-TKSDV 369 RDL NVL+ AK++DFGL+ S + T + APE + + ++ + D+ Sbjct: 130 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 189 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAAT 429 WS G++L+ + G +P+ + + ++ G P P+V ++K+ +D Sbjct: 190 WSSGVILYALLC-GTLPFDDDHVPTLFKKICDGI-FYTPQYLNPSVISLLKHMLQVDPMK 247 Query: 430 RPTFLQLREQ 439 R + +RE Sbjct: 248 RASIKDIREH 257 >3NCG-A nrPDB Length = 486 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 27/225 (12%) Query: 201 IGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ-----AFLAEASVMTQLRHSNLVQLLG 253 +GKG FG+V+ R + AVK I N A+A+ L E ++ +L H N+++L Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVI-NKASAKNKDTSTILREVELLKKLDHPNIMKLFE 88 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 I+E+ YIV E G L D + R R S ++K V + Y+ +N VH Sbjct: 89 -ILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIK---QVFSGITYMHKHNIVH 144 Query: 313 RDLAARNVLV---SEDNVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPEALREKKFS 364 RDL N+L+ +D K+ DFGL ++ Q K+ + + APE LR + Sbjct: 145 RDLKPENILLESKEKDCDIKIIDFGL---STCFQQNTKMKDRIGTAYYIAPEVLR-GTYD 200 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP 408 K DVWS G++L+ + S G P+ D++ RVE G Y D P Sbjct: 201 EKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLP 244 >1A81-A nrPDB Length = 254 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 51/105 (48%), Positives = 61/105 (58%), Gaps = 4/105 (3%) Query: 69 EGVKAGTKLSLMPWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCEGKV 126 E + A T MPWFHGKI+RE++E+ L+ G FL+R N G Y LC+ EGKV Sbjct: 147 EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKV 205 Query: 127 EHYRI-MYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 HYRI KLSI E F+ L QLVEHY+ ADGL L P Sbjct: 206 LHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVP 250 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 3/94 (3%) Query: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS- 136 +P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I + Sbjct: 5 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 64 Query: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 +I + L +++ ++DGL L KP Sbjct: 65 TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 98 >3ZDU-A nrPDB Length = 325 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 101/198 (51%), Gaps = 12/198 (6%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI---KNDATAQAFLAEASVMTQLRH 245 +M+ + L +G+G +G VM ++ G VA+K + + + E + Q H Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHH 60 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 NLV L+ V +K +++V E++ +++D L+ L L K+ + A++YL Sbjct: 61 ENLVNLIEVF-RQKKKIHLVFEFI-DHTVLDELQHYCHG-LESKRLRKYLFQILRAIDYL 117 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT--GKLPVKW-TAPE-ALREK 361 NN +HRD+ N+LVS+ + K+ DFG + ++ D ++ +W APE L++ Sbjct: 118 HSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDT 177 Query: 362 KFSTKSDVWSFGILLWEI 379 + D+W+ G ++ E+ Sbjct: 178 SYGKPVDIWALGCMIIEM 195 >2JC6-A nrPDB Length = 334 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 78/268 (29%), Positives = 125/268 (46%), Gaps = 23/268 (8%) Query: 186 SGWALNMKELKLL----QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDA---TAQAFLAE 236 S W +++K + +T+G G F +V+L + + G AVKCI A + E Sbjct: 11 SSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENE 70 Query: 237 ASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG-RSVLGGDCLLKFS 295 +V+ +++H N+V L I E LY+V + ++ G L D + +G + L++ Sbjct: 71 IAVLRKIKHENIVALED-IYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQV 129 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLV-SEDNVAKV--SDFGLTKE--ASSTQDTGKLPV 350 LD A+ YL VHRDL N+L S+D +K+ SDFGL+K T Sbjct: 130 LD---AVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP 186 Query: 351 KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP- 408 + APE L +K +S D WS G++ + I G P+ + ++ K Y+ D+P Sbjct: 187 GYVAPEVLAQKPYSKAVDCWSIGVIAY-ILLCGYPPFYDENDSKLFEQILKAEYEFDSPY 245 Query: 409 -DGCPPAVYDVMKNCWHLDAATRPTFLQ 435 D + D ++N D R T Q Sbjct: 246 WDDISDSAKDFIRNLMEKDPNKRYTCEQ 273 >5N23-A nrPDB Length = 352 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 67/272 (24%), Positives = 121/272 (44%), Gaps = 29/272 (10%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQL 243 ++ + + ++T+G G FG VML ++ GN A+K + + L E + + Sbjct: 40 HLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAV 99 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 LV+L ++ LY+V EY G + +LR GR ++ + E Sbjct: 100 NFPFLVKL-EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFE 156 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWT--------AP 355 YL + ++RDL N+L+ + KV+DFG K G+ P WT AP Sbjct: 157 YLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVK-----GRTP--WTLCGTPEYLAP 209 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E + K ++ D W+ G+L++E+ + G P+ + ++ G K+ P + Sbjct: 210 EIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDL 267 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 D+++N +D R F L+ + I+ H+ Sbjct: 268 KDLLRNLLQVDLTKR--FGNLKNGVNDIKNHK 297 >2WQN-A nrPDB Length = 310 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 56/204 (27%), Positives = 102/204 (50%), Gaps = 21/204 (10%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR------GNKVAVKCIK----NDATAQA-FLAEASVM 240 + ++ + IG+G+F +V YR G VA+K ++ DA A+A + E ++ Sbjct: 31 LANFRIEKKIGRGQFSEV----YRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLL 86 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR--SRGRSVLGGDCLLKFSLDV 298 QL H N+++ +E+ L IV E G L ++ + + ++ + K+ + + Sbjct: 87 KQLNHPNVIKYYASFIED-NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQL 145 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAP 355 C A+E++ +HRD+ NV ++ V K+ D GL + SS V + +P Sbjct: 146 CSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSP 205 Query: 356 EALREKKFSTKSDVWSFGILLWEI 379 E + E ++ KSD+WS G LL+E+ Sbjct: 206 ERIHENGYNFKSDIWSLGCLLYEM 229 >5D9K-A nrPDB Length = 330 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 63/251 (25%), Positives = 125/251 (49%), Gaps = 21/251 (8%) Query: 194 ELKLLQTIGKGEFGDVML-----GDYRGNKVAVKCIKNDATAQA-----FLAEASVMTQL 243 + +LL+ +G+G FG V L G A+K +K AT + E ++ ++ Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKK-ATLKVRDRVRTKMERDILVEV 89 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAM 302 H +V+L + +G LY++ +++ G L L + V+ + +KF L ++ A+ Sbjct: 90 NHPFIVKL-HYAFQTEGKLYLILDFLRGGDLFTRL---SKEVMFTEEDVKFYLAELALAL 145 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAPEALR 359 ++L ++RDL N+L+ E+ K++DFGL+KE+ + V++ APE + Sbjct: 146 DHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN 205 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 + + +D WSFG+L++E+ + G +P+ K+ + + K K+ P P ++ Sbjct: 206 RRGHTQSADWWSFGVLMFEMLT-GTLPFQGKDRKETMTMILKA-KLGMPQFLSPEAQSLL 263 Query: 420 KNCWHLDAATR 430 + + + A R Sbjct: 264 RMLFKRNPANR 274 >4NST-A nrPDB Length = 351 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 102/208 (49%), Gaps = 22/208 (10%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRHSN 247 + ++ IG+G +G V + G VA+K ++ D + F + E ++ QL H + Sbjct: 14 KFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRS 73 Query: 248 LVQLLGVIVE---------EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 +V + ++ + +KG Y+V EYM L+ L S G D + F + Sbjct: 74 VVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFSEDHIKSFMKQL 131 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD---TGKLPVKWTAP 355 E +EY NF+HRD+ N+L++ K++DFGL + +S + T K+ W P Sbjct: 132 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 191 Query: 356 EALR--EKKFSTKSDVWSFGILLWEIYS 381 L E++++ DVWS G +L E+++ Sbjct: 192 PELLLGEERYTPAIDVWSCGCILGELFT 219 >4RED-A nrPDB Length = 351 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 65/250 (26%), Positives = 116/250 (46%), Gaps = 15/250 (6%) Query: 200 TIGKGEFGDVMLGDYR--GNKVAVKC-----IKNDATAQAFLAEASVMTQLRHSNLVQLL 252 T+G G FG V +G + G+ VAVK I++ E + RH ++++L Sbjct: 21 TLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 80 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 VI +++V EY++ G L DY+ GR L + + ++Y + VH Sbjct: 81 QVI-STPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVDYCHRHMVVH 137 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKFS-TKSDV 369 RDL NVL+ AK++DFGL+ S + T + APE + + ++ + D+ Sbjct: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAAT 429 WS G++L+ + G +P+ + + ++ G P P+V ++K+ +D Sbjct: 198 WSSGVILYALLC-GTLPFDDDHVPTLFKKICDGI-FYTPQYLNPSVISLLKHMLQVDPMK 255 Query: 430 RPTFLQLREQ 439 R + +RE Sbjct: 256 RASIKDIREH 265 >2YZA-A nrPDB Length = 276 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 68/251 (27%), Positives = 121/251 (48%), Gaps = 17/251 (6%) Query: 200 TIGKGEFGDVMLGDYR--GNKVAVKC-----IKNDATAQAFLAEASVMTQLRHSNLVQLL 252 T+G G FG V +G+++ G+KVAVK I++ E + RH ++++L Sbjct: 18 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 77 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 VI ++V EY++ G L DY+ GR V + F + A++Y + VH Sbjct: 78 QVI-STPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQ-QILSAVDYCHRHMVVH 134 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTGKLPVKWTAPEALREKKFS-TKSD 368 RDL NVL+ AK++DFGL+ S + D+ P + APE + + ++ + D Sbjct: 135 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSP-NYAAPEVISGRLYAGPEVD 193 Query: 369 VWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAA 428 +WS G++L+ + G +P+ + + ++ G P+ +V ++ + +D Sbjct: 194 IWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPL 251 Query: 429 TRPTFLQLREQ 439 R T +RE Sbjct: 252 KRATIKDIREH 262 >3D2K-A nrPDB Length = 272 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 64/262 (24%), Positives = 120/262 (45%), Gaps = 20/262 (7%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQA-----FLAEASVMTQL 243 +++ + + +GKG+FG+V L R +K +A+K + +A E + + L Sbjct: 10 TLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHL 69 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 RH N+++L G + +Y++ EY G++ L+ R + ++ A+ Sbjct: 70 RHPNILRLYGYF-HDATRVYLILEYAPLGTVYRELQKLSR--FDEQRTATYITELANALS 126 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT---GKLPVKWTAPEALRE 360 Y +HRD+ N+L+ + K++DFG + A S++ T G L + PE + Sbjct: 127 YCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTL--DYLPPEMIEG 184 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 + K D+WS G+L +E + G P+ ++ R+ + + PD D++ Sbjct: 185 RMHDEKVDLWSLGVLCYE-FLVGMPPFEAHTYQETYRRISR-VEFTFPDFVTEGARDLIS 242 Query: 421 NCWHLDAATRPTFLQLREQLEH 442 +A+ R L L E LEH Sbjct: 243 RLLKHNASQR---LTLAEVLEH 261 >2JDO-A nrPDB Length = 342 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 99/209 (47%), Gaps = 16/209 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVK--CIKNDATAQAFLAEASVMT 241 + M + L+ +GKG FG V+L G Y K+ K I D A + E+ V+ Sbjct: 7 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHT-VTESRVLQ 65 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 RH L L + L V EY G L +L SR R V + + ++ A Sbjct: 66 NTRHPFLTAL-KYAFQTHDRLCFVMEYANGGELFFHL-SRER-VFTEERARFYGAEIVSA 122 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAPEAL 358 +EYL + V+RD+ N+++ +D K++DFGL KE S T K ++ APE L Sbjct: 123 LEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVL 182 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPY 387 + + D W G++++E+ GR+P+ Sbjct: 183 EDNDYGRAVDWWGLGVVMYEMMC-GRLPF 210 >3H4J-B nrPDB Length = 336 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 71/251 (28%), Positives = 123/251 (49%), Gaps = 20/251 (7%) Query: 199 QTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFL-----AEASVMTQLRHSNLVQL 251 +T+G+G FG V L + KVA+K I ++ + E S + LRH ++++L Sbjct: 15 ETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKL 74 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 VI + +V EY A G L DY+ + R + D +F + A+EY + V Sbjct: 75 YDVITTPTD-IVMVIEY-AGGELFDYIVEKKR--MTEDEGRRFFQQIICAIEYCHRHKIV 130 Query: 312 HRDLAARNVLVSEDNVAKVSDFGLTK---EASSTQDTGKLPVKWTAPEALREKKFS-TKS 367 HRDL N+L+ ++ K++DFGL+ + + + + P + APE + K ++ + Sbjct: 131 HRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSP-NYAAPEVINGKLYAGPEV 189 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPDGCPPAVYDVMKNCWHLD 426 DVWS GI+L+ + GR+P+ + ++ +V Y M PD P +++ D Sbjct: 190 DVWSCGIVLY-VMLVGRLPFDDEFIPNLFKKVNSCVYVM--PDFLSPGAQSLIRRMIVAD 246 Query: 427 AATRPTFLQLR 437 R T ++R Sbjct: 247 PMQRITIQEIR 257 >2XIK-A nrPDB Length = 294 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 55/190 (28%), Positives = 95/190 (50%), Gaps = 12/190 (6%) Query: 198 LQTIGKGEFGDVMLG--DYRGNKVAVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLL 252 L IGKG FG+V G ++ VA+K I + + + E +V++Q + + Sbjct: 24 LDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYF 83 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 G ++ L+I+ EY+ GS +D L+ L + ++ + ++YL +H Sbjct: 84 GSYLKSTK-LWIIMEYLGGGSALDLLKP---GPLEETYIATILREILKGLDYLHSERKIH 139 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDV 369 RD+ A NVL+SE K++DFG+ + + TQ V W APE +++ + K+D+ Sbjct: 140 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADI 199 Query: 370 WSFGILLWEI 379 WS GI E+ Sbjct: 200 WSLGITAIEL 209 >6E2O-A nrPDB Length = 295 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 60/198 (30%), Positives = 102/198 (51%), Gaps = 13/198 (6%) Query: 201 IGKGEFGDVMLGDYRGNKV--AVKCI--KNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 +GKG +G V G N+V A+K I ++ +Q E ++ L+H N+VQ LG Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF- 88 Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF-SLDVCEAMEYLEGNNFVHRDL 315 E G + I E + GSL LRS+ + + + F + + E ++YL N VHRD+ Sbjct: 89 SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDI 148 Query: 316 AARNVLVSE-DNVAKVSDFGLTKEASSTQ---DTGKLPVKWTAPEALRE--KKFSTKSDV 369 NVL++ V K+SDFG +K + +T +++ APE + + + + +D+ Sbjct: 149 KGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADI 208 Query: 370 WSFGILLWEIYSFGRVPY 387 WS G + E+ + G+ P+ Sbjct: 209 WSLGCTIIEMAT-GKPPF 225 >5EFQ-A nrPDB Length = 347 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 102/208 (49%), Gaps = 22/208 (10%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRHSN 247 + ++ IG+G +G V + G VA+K ++ D + F + E ++ QL H + Sbjct: 12 KFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQS 71 Query: 248 LVQLLGVIVE---------EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 ++ + ++ + +KG Y+V EYM L+ L S G + + F + Sbjct: 72 IINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFNENHIKSFMRQL 129 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD---TGKLPVKWTAP 355 E ++Y NF+HRD+ N+L++ K++DFGL + SS + T K+ W P Sbjct: 130 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 189 Query: 356 EALR--EKKFSTKSDVWSFGILLWEIYS 381 L E++++ DVWS G +L E+++ Sbjct: 190 PELLLGEERYTPAIDVWSCGCILGELFT 217 >6FDY-U nrPDB Length = 276 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 109/224 (48%), Gaps = 17/224 (7%) Query: 197 LLQTIGKGEFGDVMLGDYRGNK---VAVKCIK----NDATAQAFLAEASVMTQLRHSNLV 249 L + +G G + V + + VA+KC+ N A+ + L E ++ +RH ++V Sbjct: 15 LTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIV 74 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 QL + +Y++ E+ A G L ++ +R +L F + A+++L N Sbjct: 75 QLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTR--RILPEKVARVFMQQLASALQFLHERN 131 Query: 310 FVHRDLAARNVLVS--EDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAPEALREKKFS 364 H DL +N+L+S E K++DFG + S + L P+ + APE + ++++ Sbjct: 132 ISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL-YMAPEMVCQRQYD 190 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP 408 + D+WS G++L+E FG+ P+ ++ ++ ++ P Sbjct: 191 ARVDLWSMGVILYEAL-FGQPPFASRSFSELEEKIRSNRVIELP 233 >3MN3-A nrPDB Length = 271 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/203 (30%), Positives = 107/203 (52%), Gaps = 17/203 (8%) Query: 196 KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLA-----EASVMTQLRHSNL 248 ++++T+G+G FG V L + G KVA+K I A++ + E S + LRH ++ Sbjct: 7 QIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHI 66 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 ++L VI + K + +V EY A L DY+ R + + +F + A+EY + Sbjct: 67 IKLYDVI-KSKDEIIMVIEY-AGNELFDYIVQRDK--MSEQEARRFFQQIISAVEYCHRH 122 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTK---EASSTQDTGKLPVKWTAPEALREKKFS- 364 VHRDL N+L+ E K++DFGL+ + + + + P + APE + K ++ Sbjct: 123 KIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSP-NYAAPEVISGKLYAG 181 Query: 365 TKSDVWSFGILLWEIYSFGRVPY 387 + DVWS G++L+ + R+P+ Sbjct: 182 PEVDVWSCGVILYVMLC-RRLPF 203 >6CMJ-A nrPDB Length = 321 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 109/221 (49%), Gaps = 28/221 (12%) Query: 190 LNMKELKLLQTIGKGEFGDVMLG------DYRGNKVAVK---------CIKNDATAQAFL 234 + + + L IGKG +G V L Y KV K CI+ + Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 235 AEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 293 E +++ +L H N+V+L+ V+ + + LY+V E + +G +++ + L D Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKP---LSEDQARF 147 Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST----QDTGKLP 349 + D+ + +EYL +HRD+ N+LV ED K++DFG++ E + +T P Sbjct: 148 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 207 Query: 350 VKWTAPEALRE--KKFSTKS-DVWSFGILLWEIYSFGRVPY 387 + APE+L E K FS K+ DVW+ G+ L+ + FG+ P+ Sbjct: 208 A-FMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPF 246 >3PFQ-A nrPDB Length = 674 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/245 (25%), Positives = 114/245 (46%), Gaps = 24/245 (9%) Query: 163 LCTRLIKPKVMEGTVAAQDE-------FYRSGWALNMK--ELKLLQTIGKGEFGDVMLGD 213 L + + K+ +GT A +++ F +G MK + L +GKG FG VML + Sbjct: 302 LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE 361 Query: 214 YRGNK--VAVKCIKNDATAQ-----AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVT 266 +G AVK +K D Q + E V+ + L + LY V Sbjct: 362 RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM 421 Query: 267 EYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDN 326 EY+ G L+ +++ GR + ++ ++ + +L+ ++RDL NV++ + Sbjct: 422 EYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG 479 Query: 327 VAKVSDFGLTKE----ASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSF 382 K++DFG+ KE +T+ P + APE + + + D W+FG+LL+E+ + Sbjct: 480 HIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA- 537 Query: 383 GRVPY 387 G+ P+ Sbjct: 538 GQAPF 542 >4M66-A nrPDB Length = 325 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/269 (28%), Positives = 122/269 (45%), Gaps = 35/269 (13%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQ 250 +ELK L+ +GKG FG V +R + VAVK + + + E M LR+ N++ Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW----EVKAMVNLRNENVLL 75 Query: 251 LLGVIVEEK----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 LLGV + + G +VT +M GSL L+ C + +V M YL Sbjct: 76 LLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLC--RLLQEVVLGMCYLH 133 Query: 307 GNN--FVHRDLAARNVLVSEDNVAKVSDFGLT---------KEASSTQDTGKLPVKWTAP 355 + +HRDL N+L+ + AK++DFGL+ + S + + P Sbjct: 134 SLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDP 193 Query: 356 EALREK--KFSTKSDVWSFGILLWEIYSFGR----VPYPRIPLKDVVPRVEKGYKMDAPD 409 E L + K S SDV+SFGIL+W + + GR V + + V R + + P Sbjct: 194 ELLFKVNLKASKASDVYSFGILVWAVLA-GREAELVDKTSLIRETVCDRQSRPPLTELPP 252 Query: 410 GCPPA-----VYDVMKNCWHLDAATRPTF 433 G P + ++M +CW + RP+F Sbjct: 253 GSPETPGLEKLKELMIHCWGSQSENRPSF 281 >3MV5-A nrPDB Length = 342 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 99/210 (47%), Gaps = 17/210 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVK--CIKNDATAQAFLAEASVMT 241 + M E + L+ +GKG FG V+L G Y K+ K + D A L E V+ Sbjct: 7 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQ 65 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 RH L L + L V EY G L +L SR R V D + ++ A Sbjct: 66 NSRHPFLTAL-KYSFQTHDRLCFVMEYANGGELFFHL-SRER-VFSEDRARFYGAEIVSA 122 Query: 302 MEYLEG-NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEA 357 ++YL N V+RDL N+++ +D K++DFGL KE +T T ++ APE Sbjct: 123 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 182 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 L + + D W G++++E+ GR+P+ Sbjct: 183 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 211 >2I0E-A nrPDB Length = 353 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 99/209 (47%), Gaps = 15/209 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ-----AFLAEASVMTQ 242 + + + L +GKG FG VML + +G AVK +K D Q + E V+ Sbjct: 17 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 76 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + L + LY V EY+ G L+ +++ GR + ++ ++ + Sbjct: 77 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGL 134 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE----ASSTQDTGKLPVKWTAPEAL 358 +L+ ++RDL NV++ + K++DFG+ KE +T+ P + APE + Sbjct: 135 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEII 193 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPY 387 + + D W+FG+LL+E+ + G+ P+ Sbjct: 194 AYQPYGKSVDWWAFGVLLYEMLA-GQAPF 221 >5KCV-A nrPDB Length = 460 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 99/210 (47%), Gaps = 17/210 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVK--CIKNDATAQAFLAEASVMT 241 + M E + L+ +GKG FG V+L G Y K+ K + D A L E V+ Sbjct: 159 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQ 217 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 RH L L + L V EY G L +L SR R V D + ++ A Sbjct: 218 NSRHPFLTAL-KYSFQTHDRLCFVMEYANGGELFFHL-SRER-VFSEDRARFYGAEIVSA 274 Query: 302 MEYLEG-NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEA 357 ++YL N V+RDL N+++ +D K++DFGL KE +T T ++ APE Sbjct: 275 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 334 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 L + + D W G++++E+ GR+P+ Sbjct: 335 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 363 >3NIZ-A nrPDB Length = 311 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 113/219 (51%), Gaps = 17/219 (7%) Query: 192 MKELKLLQTIGKGEFGDVMLG-DYRGNKVAVKCIKNDATAQAF----LAEASVMTQLRHS 246 M++ + L+ +G+G +G V D +G VA+K I+ DA + + E S++ +L H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHP 79 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V L+ VI E+ L +V E+M K + + ++ L + + + + + Sbjct: 80 NIVSLIDVIHSERC-LTLVFEFMEKD--LKKVLDENKTGLQDSQIKIYLYQLLRGVAHCH 136 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE-----ASSTQDTGKLPVKWTAPEALR-E 360 + +HRDL +N+L++ D K++DFGL + S T + L + AP+ L Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTL--WYRAPDVLMGS 194 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 KK+ST D+WS G + E+ + G+ +P + D +P++ Sbjct: 195 KKYSTSVDIWSIGCIFAEMIT-GKPLFPGVTDDDQLPKI 232 >2UV2-A nrPDB Length = 325 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 71/262 (27%), Positives = 123/262 (46%), Gaps = 31/262 (11%) Query: 196 KLLQTIGKGEFGDVMLGDYRGNKV--AVKCI--KNDATAQAFLAEASVMTQLRHSNLVQL 251 +++ +G G FG V + V A K I K++ + ++ E ++ H N+V+L Sbjct: 40 EIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKL 99 Query: 252 LGVIVEEKGGLYIVTEYMAKGS----LVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 L E L+I+ E+ A G+ +++ R S + C K +LD A+ YL Sbjct: 100 LDAFYYE-NNLWILIEFCAGGAVDAVMLELERPLTESQIQVVC--KQTLD---ALNYLHD 153 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAPEAL-----R 359 N +HRDL A N+L + D K++DFG++ + + T +D+ W APE + + Sbjct: 154 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 213 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY--- 416 ++ + K+DVWS GI L E+ + P++ ++ K K + P P+ + Sbjct: 214 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLL----KIAKSEPPTLAQPSRWSSN 269 Query: 417 --DVMKNCWHLDAATRPTFLQL 436 D +K C + R T QL Sbjct: 270 FKDFLKKCLEKNVDARWTTSQL 291 >5EZV-A nrPDB Length = 560 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 67/250 (26%), Positives = 119/250 (47%), Gaps = 15/250 (6%) Query: 200 TIGKGEFGDVMLGDYR--GNKVAVKC-----IKNDATAQAFLAEASVMTQLRHSNLVQLL 252 T+G G FG V +G+++ G+KVAVK I++ E + RH ++++L Sbjct: 35 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 94 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 VI ++V EY++ G L DY+ GR V + F + A++Y + VH Sbjct: 95 QVI-STPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQ-QILSAVDYCHRHMVVH 151 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKFS-TKSDV 369 RDL NVL+ AK++DFGL+ S + T + APE + + ++ + D+ Sbjct: 152 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 211 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAAT 429 WS G++L+ + G +P+ + + ++ G P+ +V ++ + +D Sbjct: 212 WSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPLK 269 Query: 430 RPTFLQLREQ 439 R T +RE Sbjct: 270 RATIKDIREH 279 >3IS5-A nrPDB Length = 285 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 69/254 (27%), Positives = 123/254 (48%), Gaps = 25/254 (9%) Query: 201 IGKGEFGDVMLGDYR--GNKVAVKCIKNDATA---QAFLAEASVMTQLRHSNLVQLLGVI 255 +G G FGDV L + R G + +K I D + + AE V+ L H N++++ V Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPNIIKIFEVF 89 Query: 256 VEEKGGLYIVTEYMAKGSLVDYL---RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 E+ +YIV E G L++ + ++RG+++ G + + + A+ Y + VH Sbjct: 90 -EDYHNMYIVMETCEGGELLERIVSAQARGKALSEG-YVAELMKQMMNALAYFHSQHVVH 147 Query: 313 RDLAARNVL---VSEDNVAKVSDFGLTK----EASSTQDTGKLPVKWTAPEALREKKFST 365 +DL N+L S + K+ DFGL + + ST G + APE + + + Sbjct: 148 KDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGT--ALYMAPEVFK-RDVTF 204 Query: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV---EKGYKMDAPDGCPPAVYDVMKNC 422 K D+WS G++++ + + G +P+ L++V + E Y ++ P AV D++K Sbjct: 205 KCDIWSAGVVMYFLLT-GCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAV-DLLKQM 262 Query: 423 WHLDAATRPTFLQL 436 D RP+ Q+ Sbjct: 263 LTKDPERRPSAAQV 276 >4RLP-A nrPDB Length = 288 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/250 (24%), Positives = 117/250 (46%), Gaps = 19/250 (7%) Query: 195 LKLLQTIGKGEFGDV-----MLGDYRGNKVAVKCIK------NDATAQAFLAEASVMTQL 243 +LL+ +GKG +G V + G G A+K +K N AE +++ ++ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +H +V L+ + G LY++ EY++ G L L G + C + ++ A+ Sbjct: 67 KHPFIVDLI-YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACF--YLAEISMALG 123 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEALRE 360 +L ++RDL N++++ K++DFGL KE+ + T +++ APE L Sbjct: 124 HLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMR 183 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 + D WS G L++++ + G P+ K + ++ K K++ P D++K Sbjct: 184 SGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILK-CKLNLPPYLTQEARDLLK 241 Query: 421 NCWHLDAATR 430 +AA+R Sbjct: 242 KLLKRNAASR 251 >4RA4-A nrPDB Length = 355 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 100/209 (47%), Gaps = 15/209 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ-----AFLAEASVMTQ 242 + + + L +GKG FG VML D +G + A+K +K D Q + E V+ Sbjct: 17 VKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLAL 76 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L + L + LY V EY+ G L+ +++ G+ + ++ ++ + Sbjct: 77 LDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAEISIGL 134 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE----ASSTQDTGKLPVKWTAPEAL 358 +L ++RDL NV++ + K++DFG+ KE +T+ P + APE + Sbjct: 135 FFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTP-DYIAPEII 193 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPY 387 + + D W++G+LL+E+ + G+ P+ Sbjct: 194 AYQPYGKSVDWWAYGVLLYEMLA-GQPPF 221 >4CFF-A nrPDB Length = 571 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 67/250 (26%), Positives = 119/250 (47%), Gaps = 15/250 (6%) Query: 200 TIGKGEFGDVMLGDYR--GNKVAVKC-----IKNDATAQAFLAEASVMTQLRHSNLVQLL 252 T+G G FG V +G+++ G+KVAVK I++ E + RH ++++L Sbjct: 40 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 99 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 VI ++V EY++ G L DY+ GR V + F + A++Y + VH Sbjct: 100 QVI-STPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQ-QILSAVDYCHRHMVVH 156 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKFS-TKSDV 369 RDL NVL+ AK++DFGL+ S + T + APE + + ++ + D+ Sbjct: 157 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 216 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAAT 429 WS G++L+ + G +P+ + + ++ G P+ +V ++ + +D Sbjct: 217 WSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPLK 274 Query: 430 RPTFLQLREQ 439 R T +RE Sbjct: 275 RATIKDIREH 284 >4L42-A nrPDB Length = 346 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 62/250 (24%), Positives = 117/250 (46%), Gaps = 19/250 (7%) Query: 195 LKLLQTIGKGEFGDV-----MLGDYRGNKVAVKCIK------NDATAQAFLAEASVMTQL 243 +LL+ +GKG +G V + G G A+K +K N AE +++ ++ Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +H +V L+ + G LY++ EY++ G L L G + D + ++ A+ Sbjct: 80 KHPFIVDLI-YAFQTGGKLYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEISMALG 136 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEALRE 360 +L ++RDL N++++ K++DFGL KE+ + T +++ APE L Sbjct: 137 HLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMR 196 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 + D WS G L++++ + G P+ K + ++ K K++ P D++K Sbjct: 197 SGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILK-CKLNLPPYLTQEARDLLK 254 Query: 421 NCWHLDAATR 430 +AA+R Sbjct: 255 KLLKRNAASR 264 >5LPV-A nrPDB Length = 296 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 81/280 (28%), Positives = 134/280 (47%), Gaps = 43/280 (15%) Query: 201 IGKGEFGDV---MLGDYRGNKVAVKCIKNDATA--QAFLAEASVMTQLRHSNLVQLLGV- 254 IG G FGDV +L D G+ VA+K + + + + F+AE + +++H NLV LLG Sbjct: 25 IGSGGFGDVYKAILKD--GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYC 82 Query: 255 -IVEEKGGLYIVTEYMAKGSLVDYLRSRGRS--VLGGDCLLKFSLDVCEAMEYLEGN--- 308 + +E+ +V E+M GSL D L ++ L K ++ + +L N Sbjct: 83 KVGDER---LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-------WTAPEALREK 361 + +HRD+ + NVL+ E+ A+VSDFG+ + S+ DT L V + PE + Sbjct: 140 HIIHRDMKSSNVLLDENLEARVSDFGMARLMSA-MDT-HLSVSTLAGTPGYVPPEYYQSF 197 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVP--YPRIPLKDVVPRVEKGYKMDAPDGCPPAVY--- 416 + STK DV+S+G++L E+ + G+ P P ++V V++ K+ D P + Sbjct: 198 RCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKED 256 Query: 417 -----------DVMKNCWHLDAATRPTFLQLREQLEHIRT 445 V C A RPT +Q+ + I+ Sbjct: 257 PALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQA 296 >2QKW-B nrPDB Length = 321 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 55/190 (28%), Positives = 98/190 (51%), Gaps = 13/190 (6%) Query: 201 IGKGEFGDVMLGDYR-GNKVAVKCIKNDATAQAFLAEASVMTQL---RHSNLVQLLGVIV 256 IG G FG V G R G KVA+K + ++Q + + L RH +LV L+G Sbjct: 47 IGHGVFGKVYKGVLRDGAKVALKR-RTPESSQGIEEFETEIETLSFCRHPHLVSLIG-FC 104 Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG--DCLLKFSLDVCEAMEYLEGNNFVHRD 314 +E+ + ++ +YM G+L +L + + L+ + + YL +HRD Sbjct: 105 DERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRD 164 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSDV 369 + + N+L+ E+ V K++DFG++K+ + T K + + PE + + + KSDV Sbjct: 165 VKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDV 224 Query: 370 WSFGILLWEI 379 +SFG++L+E+ Sbjct: 225 YSFGVVLFEV 234 >4KS7-A nrPDB Length = 292 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 57/195 (29%), Positives = 99/195 (50%), Gaps = 14/195 (7%) Query: 201 IGKGEFGDVMLG--DYRGNKVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLL-GVI 255 IG+G G V L + G +VAVK ++ + E +M +H N+V++ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 90 Query: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315 V E+ L+++ E++ G+L D + S+ R L + + V +A+ YL +HRD+ Sbjct: 91 VGEE--LWVLMEFLQGGALTDIV-SQVR--LNEEQIATVCEAVLQALAYLHAQGVIHRDI 145 Query: 316 AARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDVWSF 372 + ++L++ D K+SDFG + S K V W APE + ++T+ D+WS Sbjct: 146 KSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSL 205 Query: 373 GILLWEIYSFGRVPY 387 GI++ E+ G PY Sbjct: 206 GIMVIEMVD-GEPPY 219 >3TXO-A nrPDB Length = 353 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 99/209 (47%), Gaps = 15/209 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ-----AFLAEASVMTQ 242 L + + ++ +GKG FG VML + G+ AVK +K D Q + E +++ Sbjct: 20 LGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSL 79 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF-SLDVCEA 301 R+ + L + L+ V E++ G L+ +++ R + +F + ++ A Sbjct: 80 ARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRF---DEARARFYAAEIISA 136 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEAL 358 + +L ++RDL NVL+ + K++DFG+ KE T T + APE L Sbjct: 137 LMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPY 387 +E + D W+ G+LL+E+ G P+ Sbjct: 197 QEMLYGPAVDWWAMGVLLYEMLC-GHAPF 224 >5LPZ-A nrPDB Length = 332 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 81/280 (28%), Positives = 134/280 (47%), Gaps = 43/280 (15%) Query: 201 IGKGEFGDV---MLGDYRGNKVAVKCIKNDATA--QAFLAEASVMTQLRHSNLVQLLGV- 254 IG G FGDV +L D G+ VA+K + + + + F+AE + +++H NLV LLG Sbjct: 25 IGSGGFGDVYKAILKD--GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYC 82 Query: 255 -IVEEKGGLYIVTEYMAKGSLVDYLRSRGRS--VLGGDCLLKFSLDVCEAMEYLEGN--- 308 + +E+ +V E+M GSL D L ++ L K ++ + +L N Sbjct: 83 KVGDER---LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-------WTAPEALREK 361 + +HRD+ + NVL+ E+ A+VSDFG+ + S+ DT L V + PE + Sbjct: 140 HIIHRDMKSSNVLLDENLEARVSDFGMARLMSA-MDT-HLSVSTLAGTPGYVPPEYYQSF 197 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVP--YPRIPLKDVVPRVEKGYKMDAPDGCPPAVY--- 416 + STK DV+S+G++L E+ + G+ P P ++V V++ K+ D P + Sbjct: 198 RCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKED 256 Query: 417 -----------DVMKNCWHLDAATRPTFLQLREQLEHIRT 445 V C A RPT +Q+ + I+ Sbjct: 257 PALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQA 296 >4QTB-A nrPDB Length = 380 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 97/200 (48%), Gaps = 20/200 (10%) Query: 198 LQTIGKGEFGDV--MLGDYRGNKVAVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLL 252 LQ IG+G +G V R +VA+K I ++ Q L E ++ + RH N++ + Sbjct: 46 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 105 Query: 253 GVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 ++ +E +YIV + M + L L+S+ L D + F + ++Y+ Sbjct: 106 DILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ---LSNDHICYFLYQILRGLKYIHSA 161 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TGKLPVKW-TAPEALREKK 362 N +HRDL N+L++ K+ DFGL + A D T + +W APE + K Sbjct: 162 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 221 Query: 363 FSTKS-DVWSFGILLWEIYS 381 TKS D+WS G +L E+ S Sbjct: 222 GYTKSIDIWSVGCILAEMLS 241 >3HDN-A nrPDB Length = 373 Score = 77.8 bits (190), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 102/205 (49%), Gaps = 15/205 (7%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIKNDATAQA-----FLAEASVMTQ-LRH 245 + L+ IGKG FG V+L ++ +V AVK ++ A + ++E +V+ + ++H Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 98 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 LV L + LY V +Y+ G L +L+ R R L ++ ++ A+ YL Sbjct: 99 PFLVGL-HFSFQTADKLYFVLDYINGGELFYHLQ-RERCFLEPRARF-YAAEIASALGYL 155 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEALREKK 362 N V+RDL N+L+ ++DFGL KE +ST T ++ APE L ++ Sbjct: 156 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 215 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPY 387 + D W G +L+E+ +G P+ Sbjct: 216 YDRTVDWWCLGAVLYEML-YGLPPF 239 >4YZB-A nrPDB Length = 491 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 82/262 (31%), Positives = 125/262 (47%), Gaps = 29/262 (11%) Query: 199 QTIGKGEFGDVML--GDYRGNKVAVKCIKNDATAQ-----AFLAEASVMTQLRHSNLVQL 251 + +GKG FG+V+L G + AVK I Q L E ++ +L H N+++L Sbjct: 36 RVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKL 95 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAMEYLEGNNF 310 E+KG Y+VTE G L D + SR R S + +++ V + Y+ N Sbjct: 96 YEFF-EDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIR---QVLSGITYMHKNKI 151 Query: 311 VHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLPVK-----WTAPEALREKK 362 VHRDL N+L+ +D ++ DFGL+ ST+ K+ K + APE L Sbjct: 152 VHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTK---KMKDKIGTAYYIAPEVLH-GT 207 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPDGCPPAVYDVMKN 421 + K DVWS G++L+ + S G P+ D++ +VEKG + D P V + K+ Sbjct: 208 YDEKCDVWSTGVILYILLS-GCPPFNGANEFDILKKVEKGKFTFDLPQW--KKVSEPAKD 264 Query: 422 CWHLDAATRPTF-LQLREQLEH 442 A PT + R+ LEH Sbjct: 265 LIRKMLAYVPTMRISARDALEH 286 >3Q5I-A nrPDB Length = 504 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 52/247 (21%) Query: 198 LQTIGKGEFGDVMLGDYRG--NKVAVKCIK-----------NDATAQAF----LAEASVM 240 ++ +G G +G+V+L + ++ A+K IK ++ + F E S++ Sbjct: 41 VRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLL 100 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 L H N+++L V E+K Y+VTE+ G L + + +R + D C+ Sbjct: 101 KSLDHPNIIKLFDVF-EDKKYFYLVTEFYEGGELFEQIINRHK------------FDECD 147 Query: 301 AME----------YLEGNNFVHRDLAARNVLVSEDNV---AKVSDFGL----TKEASSTQ 343 A YL +N VHRD+ N+L+ N K+ DFGL +K+ Sbjct: 148 AANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRD 207 Query: 344 DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG- 402 G + APE L+ KK++ K DVWS G++++ I G P+ +D++ +VEKG Sbjct: 208 RLG--TAYYIAPEVLK-KKYNEKCDVWSCGVIMY-ILLCGYPPFGGQNDQDIIKKVEKGK 263 Query: 403 YKMDAPD 409 Y D D Sbjct: 264 YYFDFND 270 >4JXF-A nrPDB Length = 266 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 101/218 (46%), Gaps = 13/218 (5%) Query: 192 MKELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLA-----EASVMTQLR 244 +++ K+ +GKG F V + + G +VA+K I A +A + E + QL+ Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H ++++L E+ +Y+V E G + YL++R + + F + M Y Sbjct: 66 HPSILELYNYF-EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEAR-HFMHQIITGMLY 123 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEALREK 361 L + +HRDL N+L++ + K++DFGL + + + +PE Sbjct: 124 LHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRS 183 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 +SDVWS G + + + GR P+ +K+ + +V Sbjct: 184 AHGLESDVWSLGCMFYTLL-IGRPPFDTDTVKNTLNKV 220 >5XZW-A nrPDB Length = 471 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 108/236 (45%), Gaps = 34/236 (14%) Query: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLLG 253 + +G+G F V R G AVK I K E V+ +L H +V+L G Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKG 261 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 E+ Y+V E+++ G L+D++ + G +G D + S + A++Y+ HR Sbjct: 262 -FYEDTESYYMVMEFVSGGDLMDFVAAHG--AVGEDAGREISRQILTAIKYIHSMGISHR 318 Query: 314 DLAARNVLVSEDN--VAKVSDFGLTKEASSTQDTGKL------PVKWTAPEALREK---- 361 DL N+L+ +D+ + K++DFGL K Q G + + APE +R K Sbjct: 319 DLKPDNILIEQDDPVLVKITDFGLAK----VQGNGSFMKTFCGTLAYVAPEVIRGKDTSV 374 Query: 362 ---------KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP 408 ++S+ D+WS G L++ I + G +P+ + ++ +G + P Sbjct: 375 SPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGP 429 >5YV8-A nrPDB Length = 298 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 111/240 (46%), Gaps = 43/240 (17%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLG------DYRGNKVAVK----------------- 222 SG + + + L IGKG +G V L Y KV K Sbjct: 6 SGDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRG 65 Query: 223 -------CIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTEYMAKGSL 274 CI+ + E +++ +L H N+V+L+ V+ + + LY+V E + +G + Sbjct: 66 TRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV 125 Query: 275 VDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG 334 ++ + L D + D+ + +EYL +HRD+ N+LV ED K++DFG Sbjct: 126 MEVPTLKP---LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFG 182 Query: 335 LTKEASST----QDTGKLPVKWTAPEALRE--KKFSTKS-DVWSFGILLWEIYSFGRVPY 387 ++ E + +T P + APE+L E K FS K+ DVW+ G+ L+ + FG+ P+ Sbjct: 183 VSNEFKGSDALLSNTVGTPA-FMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPF 240 >3T04-A nrPDB Length = 123 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 43/111 (38%), Positives = 61/111 (54%), Gaps = 7/111 (6%) Query: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120 P+NY+ ++ + W+HG ++R AE LL G FLVRES + PG ++ + Sbjct: 3 PSNYITPVNSLEKHS------WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISL 56 Query: 121 SCEGKVEHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 EG+V HYRI + KL + E F L +LV H++T ADGL T L P Sbjct: 57 RYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP 107 >5NGU-A nrPDB Length = 381 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 97/200 (48%), Gaps = 20/200 (10%) Query: 198 LQTIGKGEFGDVMLGDYRGNKV--AVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLL 252 L IG+G +G V NKV A+K I ++ Q L E ++ + RH N++ + Sbjct: 47 LSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIN 106 Query: 253 GVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 +I +E+ +YIV + M + L L+++ L D + F + ++Y+ Sbjct: 107 DIIRAPTIEQMKDVYIVQDLM-ETDLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSA 162 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TGKLPVKW-TAPEALREKK 362 N +HRDL N+L++ K+ DFGL + A D T + +W APE + K Sbjct: 163 NVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSK 222 Query: 363 FSTKS-DVWSFGILLWEIYS 381 TKS D+WS G +L E+ S Sbjct: 223 GYTKSIDIWSVGCILAEMLS 242 >1U5R-A nrPDB Length = 348 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 58/192 (30%), Positives = 92/192 (47%), Gaps = 14/192 (7%) Query: 198 LQTIGKGEFGDVMLG-DYRGNKV-AVKCI-----KNDATAQAFLAEASVMTQLRHSNLVQ 250 L+ IG G FG V D R ++V A+K + +++ Q + E + +LRH N +Q Sbjct: 59 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 118 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 G + E ++V EY GS D L + + + + + + + YL +N Sbjct: 119 YRGCYLREHTA-WLVMEY-CLGSASDLLEVHKKPLQEVE-IAAVTHGALQGLAYLHSHNM 175 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPE---ALREKKFSTKS 367 +HRD+ A N+L+SE + K+ DFG + P W APE A+ E ++ K Sbjct: 176 IHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPY-WMAPEVILAMDEGQYDGKV 234 Query: 368 DVWSFGILLWEI 379 DVWS GI E+ Sbjct: 235 DVWSLGITCIEL 246 >2GCD-A nrPDB Length = 309 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 58/192 (30%), Positives = 92/192 (47%), Gaps = 14/192 (7%) Query: 198 LQTIGKGEFGDVMLG-DYRGNKV-AVKCI-----KNDATAQAFLAEASVMTQLRHSNLVQ 250 L+ IG G FG V D R ++V A+K + +++ Q + E + +LRH N +Q Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 79 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 G + E ++V EY GS D L + + + + + + + YL +N Sbjct: 80 YRGCYLREHTA-WLVMEY-CLGSASDLLEVHKKPLQEVE-IAAVTHGALQGLAYLHSHNM 136 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPE---ALREKKFSTKS 367 +HRD+ A N+L+SE + K+ DFG + P W APE A+ E ++ K Sbjct: 137 IHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPY-WMAPEVILAMDEGQYDGKV 195 Query: 368 DVWSFGILLWEI 379 DVWS GI E+ Sbjct: 196 DVWSLGITCIEL 207 >3MIA-A nrPDB Length = 351 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 100/213 (46%), Gaps = 39/213 (18%) Query: 198 LQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRHSNLVQL 251 L IG+G FG+V +R G KVA+K + + + F L E ++ L+H N+V L Sbjct: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 Query: 252 LGVIVEE-------KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD------- 297 + + + KG +Y+V ++ + L + L+KF+L Sbjct: 82 IEICRTKASPYNRCKGSIYLVFDFC----------EHDLAGLLSNVLVKFTLSEIKRVMQ 131 Query: 298 -VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPV 350 + + Y+ N +HRD+ A NVL++ D V K++DFGL + S ++ T ++ Sbjct: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 Query: 351 KWTAPEALR--EKKFSTKSDVWSFGILLWEIYS 381 W P L E+ + D+W G ++ E+++ Sbjct: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 >5YKS-A nrPDB Length = 377 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 63/203 (31%), Positives = 99/203 (48%), Gaps = 17/203 (8%) Query: 197 LLQTIGKGEFGDVMLGD--YRGNKVAVKCI---KNDATAQAFL-AEASVMTQLRHSNLVQ 250 L +T+G+G F V L + G KVAVK I K D A L E M ++H N+V+ Sbjct: 39 LDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVR 98 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 L VI + + LY++ E G + DY+ L D K+ + A+ Y + Sbjct: 99 LYEVI-DTQTKLYLILELGDGGDMFDYIMKHEEG-LNEDLAKKYFAQIVHAISYCHKLHV 156 Query: 311 VHRDLAARNVLVSEDN-VAKVSDFGLTKEASS----TQDTGKLPVKWTAPEALREKKFST 365 VHRDL NV+ E + K++DFG + + T G L ++APE L ++ Sbjct: 157 VHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLA--YSAPEILLGDEYDA 214 Query: 366 KS-DVWSFGILLWEIYSFGRVPY 387 + D+WS G++L+ + G+ P+ Sbjct: 215 PAVDIWSLGVILFMLVC-GQPPF 236 >5DYK-A nrPDB Length = 853 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 59/204 (28%), Positives = 95/204 (46%), Gaps = 13/204 (6%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIK-----NDATAQAFLAEASVMTQLR 244 M EL+ + IG+G FG V L ++ K+ A+KC+ N E + + Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEND 597 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAME 303 H +++L+ + K Y +TE + G L D +R G L +F L + A+E Sbjct: 598 HPFIIRLVRTFKDSKY-FYFLTELVTGGELYDAIRKLG---LLSKSQAQFYLGSIILAIE 653 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 YL N V+RDL N+L+ + K+ DFG K+ T + APE + K + Sbjct: 654 YLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKGY 713 Query: 364 STKSDVWSFGILLWEIYSFGRVPY 387 D+W+ GI L+E + G +P+ Sbjct: 714 GCTVDIWALGICLYE-FICGPLPF 736 >4FIE-A nrPDB Length = 423 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 94/196 (47%), Gaps = 16/196 (8%) Query: 201 IGKGEFGDVMLGDYR--GNKVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLG--V 254 IG+G G V + R G VAVK ++ + E +M +H N+V++ + Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 218 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + +E L++V E++ G+L D + + + + + L V +A+ L +HRD Sbjct: 219 VGDE---LWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 272 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDVWS 371 + + ++L++ D K+SDFG + S K V W APE + + + D+WS Sbjct: 273 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 332 Query: 372 FGILLWEIYSFGRVPY 387 GI++ E+ G PY Sbjct: 333 LGIMVIEMVD-GEPPY 347 >4JDH-A nrPDB Length = 346 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 65/253 (25%), Positives = 116/253 (45%), Gaps = 30/253 (11%) Query: 201 IGKGEFGDVMLGDYR--GNKVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLG--V 254 IG+G G V + R G VAVK ++ + E +M +H N+V++ + Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 141 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + +E L++V E++ G+L D + + + + + L V +A+ L +HRD Sbjct: 142 VGDE---LWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 195 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDVWS 371 + + ++L++ D K+SDFG + S K V W APE + + + D+WS Sbjct: 196 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 255 Query: 372 FGILLWEIYSFGRVPY-PRIPLK-------DVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 GI++ E+ G PY PLK ++ PR++ +K+ P++ + Sbjct: 256 LGIMVIEMVD-GEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVS------PSLKGFLDRLL 308 Query: 424 HLDAATRPTFLQL 436 D A R T +L Sbjct: 309 VRDPAQRATAAEL 321 >2Q0N-A nrPDB Length = 301 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 94/196 (47%), Gaps = 16/196 (8%) Query: 201 IGKGEFGDVMLGDYR--GNKVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLG--V 254 IG+G G V + R G VAVK ++ + E +M +H N+V++ + Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 96 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + +E L++V E++ G+L D + + + + + L V +A+ L +HRD Sbjct: 97 VGDE---LWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDVWS 371 + + ++L++ D K+SDFG + S K V W APE + + + D+WS Sbjct: 151 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 210 Query: 372 FGILLWEIYSFGRVPY 387 GI++ E+ G PY Sbjct: 211 LGIMVIEMVD-GEPPY 225 >4C0T-A nrPDB Length = 974 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 60/269 (22%), Positives = 121/269 (44%), Gaps = 25/269 (9%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNL 248 N+ + K + +G+G + V+L + G + AVK + + + + + + L Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRL 323 Query: 249 VQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 LGVI ++K LY V +Y + G L+ ++ L +C F + +A++ Sbjct: 324 SNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYN--TLNEECTRHFGAQILDAIK 381 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-TGKLPV-----------K 351 Y+ N +HRDL N+L+ + +++DFG + D + + PV + Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-GYKMDAPDG 410 + +PE L K DVW+FG +++++ + G+ P+ ++ K + A G Sbjct: 442 YVSPELLENKYCGKPGDVWAFGCIIYQMIA-GKPPFKATNEYLTFQKITKLQFAFSA--G 498 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 P + D++K L + R T ++++ Sbjct: 499 FPTIIRDLIKKILVLQPSRRATIPEIQKH 527 >2Z7Q-A nrPDB Length = 321 Score = 74.7 bits (182), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 62/250 (24%), Positives = 122/250 (48%), Gaps = 21/250 (8%) Query: 195 LKLLQTIGKGEFGDVMLGDY-----RGNKVAVKCIKNDATAQA-----FLAEASVMTQLR 244 +LL+ +G+G FG V L G+ A+K +K AT + E ++ + Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK-ATLKVRDRVRTKMERDILADVN 88 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAME 303 H +V+L + +G LY++ +++ G L L + V+ + +KF L ++ ++ Sbjct: 89 HPFVVKL-HYAFQTEGKLYLILDFLRGGDLFTRL---SKEVMFTEEDVKFYLAELALGLD 144 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAPEALRE 360 +L ++RDL N+L+ E+ K++DFGL+KEA + V++ APE + Sbjct: 145 HLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNR 204 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 + S +D WS+G+L++E+ + G +P+ K+ + + K K+ P +++ Sbjct: 205 QGHSHSADWWSYGVLMFEMLT-GSLPFQGKDRKETMTLILKA-KLGMPQFLSTEAQSLLR 262 Query: 421 NCWHLDAATR 430 + + A R Sbjct: 263 ALFKRNPANR 272 >4XBR-A nrPDB Length = 366 Score = 74.7 bits (182), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 94/196 (47%), Gaps = 16/196 (8%) Query: 201 IGKGEFGDVMLGDYR--GNKVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLG--V 254 IG+G G V + R G VAVK ++ + E +M +H N+V++ + Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 161 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + +E L++V E++ G+L D + + + + + L V +A+ L +HRD Sbjct: 162 VGDE---LWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 215 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKSDVWS 371 + + ++L++ D K+SDFG + S K V W APE + + + D+WS Sbjct: 216 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 275 Query: 372 FGILLWEIYSFGRVPY 387 GI++ E+ G PY Sbjct: 276 LGIMVIEMVD-GEPPY 290 >5LOH-A nrPDB Length = 341 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 100/223 (44%), Gaps = 25/223 (11%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK-----NDATAQAFLAEASVMTQLRH 245 +++E +++ I +G FG V LG G AVK +K N AE + L Sbjct: 34 SIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALA-LSK 92 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 S + L ++ +Y+V EY+ G + L G + +K+ +V A++YL Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYG--YFDEEMAVKYISEVALALDYL 150 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV----------KWTAP 355 + +HRDL N+L+S + K++DFGL+K + +D + + + AP Sbjct: 151 HRHGIIHRDLKPDNMLISNEGHIKLTDFGLSK-VTLNRDINMMDILTTRTFCGTPDYLAP 209 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 E L + D W+ G+ L+E + +P P D P+ Sbjct: 210 ELLLGRAHGPAVDWWALGVCLFEFLT--GIP----PFNDETPQ 246 >2BPM-A nrPDB Length = 309 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 104/205 (50%), Gaps = 12/205 (5%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVM 240 G ++M+ + ++ IG+G +G V + G VA+K I+ D + + E S++ Sbjct: 1 GPLVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL 60 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 +L H N+V+LL VI E LY+V E++ + L ++ + + + + + + + Sbjct: 61 KELNHPNIVKLLDVIHTE-NKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQ 118 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQDTGKLPVKWTAPEA 357 + + + +HRDL +N+L++ + K++DFGL + T + + + APE Sbjct: 119 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178 Query: 358 LRE-KKFSTKSDVWSFGILLWEIYS 381 L K +ST D+WS G + E+ + Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVT 203 >2F9G-A nrPDB Length = 353 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 97/210 (46%), Gaps = 27/210 (12%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASVMTQLRHSNL 248 + +L +G+G +G V ++ G VA+K I+ A L E ++ +H N+ Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 Query: 249 VQLLGV----IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 + + + E +YI+ E M D R +L D + F A++ Sbjct: 72 ITIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGK-------LPVKW 352 L G+N +HRDL N+L++ + KV DFGL + A +++ TG+ + +W Sbjct: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 Query: 353 -TAPEA-LREKKFSTKSDVWSFGILLWEIY 380 APE L K+S DVWS G +L E++ Sbjct: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 >4BBM-A nrPDB Length = 331 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 73/282 (25%), Positives = 125/282 (44%), Gaps = 46/282 (16%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI----KNDATAQAFLAEASVMTQLR 244 +M++ + L +G+G +G VM + G VA+K + + + E ++ QLR Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR 82 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDY-LRSRGRSVLGGDCLLKFSLDVCEAME 303 H NLV LL V ++K Y+V E++ L D L G L + K+ + + Sbjct: 83 HENLVNLLEV-CKKKKRWYLVFEFVDHTILDDLELFPNG---LDYQVVQKYLFQIINGIG 138 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT--GKLPVKW-TAPEAL-R 359 + +N +HRD+ N+LVS+ V K+ DFG + ++ + ++ +W APE L Sbjct: 139 FCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVG 198 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYP-----------RIPLKDVVPR---------V 399 + K+ DVW+ G L+ E++ G +P + L +++PR V Sbjct: 199 DVKYGKAVDVWAIGCLVTEMF-MGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPV 257 Query: 400 EKGYKMDAPDGCPP----------AVYDVMKNCWHLDAATRP 431 G ++ P V D+ K C H+D RP Sbjct: 258 FAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRP 299 >3G2F-A nrPDB Length = 336 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/225 (29%), Positives = 107/225 (47%), Gaps = 37/225 (16%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASV--MTQLRHS 246 +L++ LKLL+ IG+G +G V G VAVK + + A Q F+ E ++ + + H Sbjct: 9 SLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVK-VFSFANRQNFINEKNIYRVPLMEHD 67 Query: 247 NLVQLL----GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 N+ + + V + + +V EY GSL YL S S C L S V + Sbjct: 68 NIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL-SLHTSDWVSSCRLAHS--VTRGL 124 Query: 303 EYL-----EGNNF----VHRDLAARNVLVSEDNVAKVSDFGLTKEASST-------QDTG 346 YL G+++ HRDL +RNVLV D +SDFGL+ + +D Sbjct: 125 AYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNA 184 Query: 347 KLP----VKWTAPEA------LREKKFSTKS-DVWSFGILLWEIY 380 + +++ APE LR+ + + K D+++ G++ WEI+ Sbjct: 185 AISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIF 229 >4KRC-A nrPDB Length = 317 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 106/208 (50%), Gaps = 16/208 (7%) Query: 194 ELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDA---TAQAFLAEASVMTQLRHSNL 248 + K L+ +G G + V L G VA+K +K D+ T + E S+M +L+H N+ Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR--GRSVLGGDCLL--KFSLDVCEAMEY 304 V+L VI E L +V E+M L Y+ SR G + G + L F + + + + Sbjct: 66 VRLYDVIHTE-NKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALR-E 360 N +HRDL +N+L+++ K+ DFGL + +T + + + + AP+ L Sbjct: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYP 388 + +ST D+WS G +L E+ + G+ +P Sbjct: 184 RTYSTSIDIWSCGCILAEMIT-GKPLFP 210 >4B8L-A nrPDB Length = 286 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 50/197 (25%), Positives = 93/197 (47%), Gaps = 12/197 (6%) Query: 199 QTIGKGEFGDVMLGDYRGNK--VAVKCI-----KNDATAQAFLAEASVMTQLRHSNLVQL 251 + +GKG+FG+V L + NK +A+K + + + E + + LRH N++++ Sbjct: 21 RPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRM 80 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 + K +Y++ E+ +G L L+ GR F ++ +A+ Y + Sbjct: 81 YNYFHDRKR-IYLMLEFAPRGELYKELQKHGR--FDEQRSATFMEELADALHYCHERKVI 137 Query: 312 HRDLAARNVLVSEDNVAKVSDFGLTKEASS-TQDTGKLPVKWTAPEALREKKFSTKSDVW 370 HRD+ N+L+ K++DFG + A S + T + + PE + K K D+W Sbjct: 138 HRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLW 197 Query: 371 SFGILLWEIYSFGRVPY 387 G+L +E + G P+ Sbjct: 198 CAGVLCYE-FLVGMPPF 213 >2XNP-A nrPDB Length = 279 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 53/224 (23%), Positives = 103/224 (45%), Gaps = 12/224 (5%) Query: 227 DATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGG-LYIVTEYMAKGSLVDYLR--SRGR 283 +A Q ++E +++ +L+H N+V+ I++ LYIV EY G L + ++ R Sbjct: 46 EAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKER 105 Query: 284 SVLGGDCLLKFSLDVCEAMEYLE-----GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 L + +L+ + A++ G+ +HRDL NV + K+ DFGL + Sbjct: 106 QYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARI 165 Query: 339 ASSTQDTGKLPVK---WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 + K V + +PE + ++ KSD+WS G LL+E+ + P+ K++ Sbjct: 166 LNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCAL-MPPFTAFSQKEL 224 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 ++ +G P + +++ +L RP+ ++ E Sbjct: 225 AGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILEN 268 >4WOV-A nrPDB Length = 317 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 99/213 (46%), Gaps = 14/213 (6%) Query: 230 AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 A AF AS+M+Q+ H++L + GV V + +VTEY+ G L +LR R R + Sbjct: 100 ALAFYETASLMSQVSHTHLAFVHGVCVRGPENI-MVTEYVEHGPLDVWLR-RERGHVPMA 157 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA-------KVSDFGLTKEASST 342 + + + A+ YLE N VH ++ RN+L++ +A K+SD G+ A S Sbjct: 158 WKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSR 217 Query: 343 QDTGKLPVKWTAPEALR--EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE 400 ++ + + W APE L ST D W FG L EI G P + + Sbjct: 218 EERVER-IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQ 276 Query: 401 KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTF 433 + +++ P C P + + C + RP+F Sbjct: 277 RQHRLPEPS-C-PQLATLTSQCLTYEPTQRPSF 307 >4BGQ-A nrPDB Length = 304 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 104/207 (50%), Gaps = 14/207 (6%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK----NDATAQAFLAEASVMTQLRH 245 M + ++L +G+G +G V+ ++ VA+K K N+ + L E ++ L+ Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+V+L +G LY+V EY+ K ++++ L V + + + + +A+ + Sbjct: 71 ENIVELKEAF-RRRGKLYLVFEYVEK-NMLELLEEMPNGV-PPEKVKSYIYQLIKAIHWC 127 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG---KLPVKW-TAPEALREK 361 N+ VHRD+ N+L+S ++V K+ DFG + S + ++ +W +PE L Sbjct: 128 HKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA 187 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYP 388 + D+WS G +L E+ S G+ +P Sbjct: 188 PYGKSVDMWSVGCILGEL-SDGQPLFP 213 >3UIM-A nrPDB Length = 326 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/197 (32%), Positives = 93/197 (47%), Gaps = 14/197 (7%) Query: 201 IGKGEFGDVMLGDYR-GNKVAVKCIKNDATAQA---FLAEASVMTQLRHSNLVQLLGVIV 256 +G+G FG V G G VAVK +K + T F E +++ H NL++L G + Sbjct: 38 LGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCM 97 Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSV--LGGDCLLKFSLDVCEAMEYLEGN---NFV 311 L +V YMA GS+ LR R S L + +L + YL + + Sbjct: 98 TPTERL-LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKII 156 Query: 312 HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWT----APEALREKKFSTKS 367 HRD+ A N+L+ E+ A V DFGL K V+ T APE L K S K+ Sbjct: 157 HRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKT 216 Query: 368 DVWSFGILLWEIYSFGR 384 DV+ +G++L E+ + R Sbjct: 217 DVFGYGVMLLELITGQR 233 >5C01-A nrPDB Length = 342 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 99/213 (46%), Gaps = 14/213 (6%) Query: 230 AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 A AF AS+M+Q+ H++L + GV V + +VTEY+ G L +LR R R + Sbjct: 123 ALAFYETASLMSQVSHTHLAFVHGVCVRGPENI-MVTEYVEHGPLDVWLR-RERGHVPMA 180 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA-------KVSDFGLTKEASST 342 + + + A+ YLE N VH ++ RN+L++ +A K+SD G+ A S Sbjct: 181 WKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSR 240 Query: 343 QDTGKLPVKWTAPEALR--EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE 400 ++ + + W APE L ST D W FG L EI G P + + Sbjct: 241 EERVER-IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQ 299 Query: 401 KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTF 433 + +++ P C P + + C + RP+F Sbjct: 300 RQHRLPEPS-C-PQLATLTSQCLTYEPTQRPSF 330 >3A8W-A nrPDB Length = 345 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 97/208 (46%), Gaps = 13/208 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGD-------YRGNKVAVKCIKNDATAQAFLAEASVMTQ 242 L +++ LL+ IG+G + V+L Y V + + +D E V Q Sbjct: 6 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 65 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + + L + + L+ V EY+ G L+ +++ + + L + +S ++ A+ Sbjct: 66 ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRK--LPEEHARFYSAEISLAL 123 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAPEALR 359 YL ++RDL NVL+ + K++D+G+ KE DT + APE LR Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 183 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 + + D W+ G+L++E+ + GR P+ Sbjct: 184 GEDYGFSVDWWALGVLMFEMMA-GRSPF 210 >6HXF-B nrPDB Length = 302 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 66/261 (25%), Positives = 119/261 (45%), Gaps = 23/261 (8%) Query: 196 KLLQTIGKGEFGDVMLGDYR--GNKVAVKCI--KNDATAQAFLAEASVMTQLRHSNLVQL 251 +++ +G G FG V + G A K I K++ + ++ E ++ H +V+L Sbjct: 22 EIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKL 81 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 LG + G L+I+ E+ G+ VD + L + + EA+ +L + Sbjct: 82 LGAYYHD-GKLWIMIEFCPGGA-VDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRII 139 Query: 312 HRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAP-----EALREKKF 363 HRDL A NVL++ + +++DFG++ + T +D+ W AP E +++ + Sbjct: 140 HRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPY 199 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY-----DV 418 K+D+WS GI L E+ + P++ ++ K K D P P+ + D Sbjct: 200 DYKADIWSLGITLIEMAQIEPPHHELNPMRVLL----KIAKSDPPTLLTPSKWSVEFRDF 255 Query: 419 MKNCWHLDAATRPTFLQLREQ 439 +K + TRP+ QL E Sbjct: 256 LKIALDKNPETRPSAAQLLEH 276 >1CM8-A nrPDB Length = 367 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 105/228 (46%), Gaps = 26/228 (11%) Query: 173 MEGTVAAQDEFYRSGWALNMKELKL----LQTIGKGEFGDV--MLGDYRGNKVAVKCIKN 226 M A+ FYR E++ LQ +G G +G V + G KVA+K + Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 Query: 227 DATAQAFLAEA----SVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAK--GSLV 275 ++ F A ++ +RH N++ LL V +++ Y+V +M G L+ Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 Query: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL 335 + + LG D + + + + Y+ +HRDL N+ V+ED K+ DFGL Sbjct: 121 KHEK------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGL 174 Query: 336 TKEASSTQDTGKLPVKW-TAPEA-LREKKFSTKSDVWSFGILLWEIYS 381 ++A S TG + +W APE L +++ D+WS G ++ E+ + Sbjct: 175 ARQADSEM-TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 >6BDL-A nrPDB Length = 347 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 93/208 (44%), Gaps = 14/208 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK---VAVKCIKN----DATAQAFLAEASVMTQ 242 L + + ++ T+G G FG V L + + A+K +K D Q + + Q Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 90 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF-SLDVCEA 301 HS+ + L ++ LY++ E G L LR RG D +F + V EA Sbjct: 91 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFE---DSTTRFYTACVVEA 147 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALR 359 YL ++RDL N+++ AK+ DFG K+ + T ++ APE + Sbjct: 148 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIIL 207 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 K +D WS GIL++E+ + G P+ Sbjct: 208 NKGHDISADYWSLGILMYELLT-GSPPF 234 >4M7I-A nrPDB Length = 299 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 106/233 (45%), Gaps = 49/233 (21%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNKV-----AVKCIK---NDATAQAFLAEASVMTQL 243 + + + +Q +G+G FG V NKV A+K I+ + + + E + +L Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAK---NKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL 60 Query: 244 RHSNLVQLLGVIVEE-----------KGGLYIVTEYMAKGSLVDYLR------SRGRSVL 286 H +V+ +E+ K LYI + K +L D++ R RSV Sbjct: 61 EHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSV- 119 Query: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG------------ 334 CL F L + EA+E+L +HRDL N+ + D+V KV DFG Sbjct: 120 ---CLHIF-LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQ 175 Query: 335 --LTKEASSTQDTGKLPVK-WTAPEALREKKFSTKSDVWSFGILLWE-IYSFG 383 LT + + TG++ K + +PE + +S K D++S G++L+E +Y F Sbjct: 176 TVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFS 228 >4PDS-A nrPDB Length = 347 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 60/236 (25%), Positives = 107/236 (45%), Gaps = 34/236 (14%) Query: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLLG 253 + +G+G F V R G +VK I K E V+ +L H +V+L G Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKG 96 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 E+ Y+V E+++ G L+D++ + G +G D + S + A++Y+ HR Sbjct: 97 -FYEDTESYYMVMEFVSGGDLMDFVAAHG--AVGEDAGREISRQILTAIKYIHSMGISHR 153 Query: 314 DLAARNVLVSEDN--VAKVSDFGLTKEASSTQDTGKL------PVKWTAPEALREK---- 361 DL N+L+ +D+ + K++ FGL K Q G + + APE +R K Sbjct: 154 DLKPDNILIEQDDPVLVKITAFGLAK----VQGNGSFMKTFCGTLAYVAPEVIRGKDTSV 209 Query: 362 ---------KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP 408 ++S+ D+WS G L++ I + G +P+ + ++ +G + P Sbjct: 210 SPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGP 264 >4OTD-A nrPDB Length = 341 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 102/212 (48%), Gaps = 18/212 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK-NDATA----QAFLAEASVM-- 240 L +++ K L +G+G FG V+L ++R G A+K +K D A ++ + E ++ Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 241 -TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 T H LV L G + + V EY A G L+ ++ S V + +S V Sbjct: 69 VTSAGHPFLVNLFGCF-QTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYSACVV 124 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAPE 356 +++L + V+RDL N+L+ + K++DFGL KE D ++ APE Sbjct: 125 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 184 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 L + ++ D W G+LL+E+ G P+P Sbjct: 185 VLTDTSYTRAVDWWGLGVLLYEML-VGESPFP 215 >3ORP-A nrPDB Length = 311 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 97/208 (46%), Gaps = 19/208 (9%) Query: 196 KLLQTIGKGEFGDVMLG-DYRGNK-VAVKCIKNDATAQA-----FLAEASVMTQLRHSNL 248 +L + +G G +V L D R ++ VAVK ++ D F EA L H + Sbjct: 15 ELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAI 74 Query: 249 VQL--LGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 V + G G L YIV EY+ +L D + + G + ++ D C+A+ + Sbjct: 75 VAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGP--MTPKRAIEVIADACQALNFS 132 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKL--PVKWTAPEALR 359 N +HRD+ N+++S N KV DFG+ + +S T + ++ +PE R Sbjct: 133 HQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQAR 192 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 +SDV+S G +L+E+ + G P+ Sbjct: 193 GDSVDARSDVYSLGCVLYEVLT-GEPPF 219 >3DB8-A nrPDB Length = 317 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 97/206 (47%), Gaps = 10/206 (4%) Query: 235 AEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 E ++ L + ++V G E+ +Y+V E + SL++ L R ++V + F Sbjct: 91 TEIAIHKSLDNPHVVGFHGFF-EDDDFVYVVLEICRRRSLLE-LHKRRKAVTEPEARY-F 147 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPV 350 + ++YL N +HRDL N+ +++D K+ DFGL + +D P Sbjct: 148 MRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTP- 206 Query: 351 KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG 410 + APE L +K S + D+WS G +L+ + G+ P+ LK+ R++K + P Sbjct: 207 NYIAPEVLCKKGHSFEVDIWSLGCILYTLL-VGKPPFETSCLKETYIRIKKN-EYSVPRH 264 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQL 436 P +++ H D RP+ +L Sbjct: 265 INPVASALIRRMLHADPTLRPSVAEL 290 >5J5T-A nrPDB Length = 370 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 62/246 (25%), Positives = 112/246 (45%), Gaps = 22/246 (8%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASV--MTQLRHS 246 + ++ +L+Q IG G +GDV G A+K IK + + + + M +H Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHP 61 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V G + + L+I E+ GSL D G L + S + + + YL Sbjct: 62 NIVAYFGSYLR-RDKLWICMEFCGGGSLQDIYHVTG--PLSELQIAYVSRETLQGLYYLH 118 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEAL---RE 360 +HRD+ N+L++++ K++DFG++ + ++T K + W APE R+ Sbjct: 119 SKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERK 178 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 ++ D+W+ GI E+ + P+ D+ P + + M + PP + D MK Sbjct: 179 GGYNQLCDLWAVGITAIELAEL------QPPMFDLHP-MRALFLMTKSNFQPPKLKDKMK 231 Query: 421 --NCWH 424 N +H Sbjct: 232 WSNSFH 237 >4I6B-A nrPDB Length = 308 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 94/207 (45%), Gaps = 14/207 (6%) Query: 199 QTIGKGEFGDVM-LGDYRGNKV-AVKCIKNDATAQAFL-----AEASVMTQLRHSNLVQL 251 +T+GKG F + D NKV A K I + ++ E + L H ++VQ Sbjct: 34 KTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQF 93 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 E+K +YI+ EY ++ S+ L++R VL + + + ++YL + Sbjct: 94 YHYF-EDKENIYILLEYCSRRSMAHILKAR--KVLTEPEVRYYLRQIVSGLKYLHEQEIL 150 Query: 312 HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAPEALREKKFSTKSD 368 HRDL N ++E KV DFGL + + + +PE L ++ +SD Sbjct: 151 HRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGAESD 210 Query: 369 VWSFGILLWEIYSFGRVPYPRIPLKDV 395 +W+ G +++ + GR P+ LK+ Sbjct: 211 IWALGCVMYTML-LGRPPFETTNLKET 236 >4AGU-A nrPDB Length = 311 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 78/299 (26%), Positives = 132/299 (44%), Gaps = 48/299 (16%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI---KNDATAQAF-LAEASVMTQLRH 245 M++ + + IG+G +G V R G VA+K ++D + L E ++ QL+H Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRGRSVLGGDCLLKFSLDVCEAMEY 304 NLV LL V K L++V EY L + R RG + + + +A+ + Sbjct: 62 PNLVNLLEVF-RRKRRLHLVFEYCDHTVLHELDRYQRG---VPEHLVKSITWQTLQAVNF 117 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKW-TAPEALR-E 360 +N +HRD+ N+L+++ +V K+ DFG + + D ++ +W +PE L + Sbjct: 118 CHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGD 177 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYP-----------RIPLKDVVPRVEK-------- 401 ++ DVW+ G + E+ S G +P R L D++PR ++ Sbjct: 178 TQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYF 236 Query: 402 -GYKMDAPDGCPP----------AVYDVMKNCWHLDAATRPTFLQLREQ--LEHIRTHE 447 G K+ P+ P ++K C H+D R T QL E+IR E Sbjct: 237 SGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIE 295 >4FR4-A nrPDB Length = 384 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 94/213 (44%), Gaps = 22/213 (10%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAV--------KCIKNDATAQAFLAEASVMT 241 +N ++L+ IGKG FG V + K KC++ + F E +M Sbjct: 12 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVF-KELQIMQ 70 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 L H LV L +E+ +++V + + G L +L+ + + F ++ A Sbjct: 71 GLEHPFLVNLWYSFQDEED-MFMVVDLLLGGDLRYHLQQNVH--FKEETVKLFICELVMA 127 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTAPEA 357 ++YL+ +HRD+ N+L+ E ++DF L +E T G P + APE Sbjct: 128 LDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKP--YMAPEM 185 Query: 358 LREKK---FSTKSDVWSFGILLWEIYSFGRVPY 387 +K +S D WS G+ +E+ GR PY Sbjct: 186 FSSRKGAGYSFAVDWWSLGVTAYELLR-GRRPY 217 >4J52-A nrPDB Length = 293 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 92/204 (45%), Gaps = 8/204 (3%) Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E S+ L H ++V G E+ +++V E + SL++ + R L + Sbjct: 64 EISIHRSLAHQHVVGFHGFF-EDNDFVFVVLELCRRRSLLEL--HKRRKALTEPEARYYL 120 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKW 352 + +YL N +HRDL N+ ++ED K+ DFGL + + K+ + Sbjct: 121 RQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNY 180 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 APE L +K S + DVWS G +++ + G+ P+ LK+ R++K + P Sbjct: 181 IAPEVLSKKGHSFEVDVWSIGCIMYTLL-VGKPPFETSCLKETYLRIKKN-EYSIPKHIN 238 Query: 413 PAVYDVMKNCWHLDAATRPTFLQL 436 P +++ D RPT +L Sbjct: 239 PVAASLIQKMLQTDPTARPTINEL 262 >5FET-A nrPDB Length = 847 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 96/206 (46%), Gaps = 13/206 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIKNDAT-----AQAFLAEASVMTQ 242 + M EL+ + IG+G FG V L ++ ++ A+KC+ + E + + Sbjct: 530 VEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAE 589 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEA 301 H +++L+ ++ Y +TE + G L D +R G L +F L + A Sbjct: 590 NDHPFIIRLVRTF-KDSNCFYFLTELVTGGELYDAIRKLG---LLSKPQAQFYLGSIILA 645 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREK 361 +EYL N V+RDL N+L+ + K+ DFG K+ T + APE + K Sbjct: 646 IEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGK 705 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPY 387 + D+W+ G+ L+E + G +P+ Sbjct: 706 GYGCTVDIWALGVCLYE-FICGPLPF 730 >2OU7-A nrPDB Length = 335 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 92/204 (45%), Gaps = 8/204 (3%) Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E S+ L H ++V G E+ +++V E + SL++ + R L + Sbjct: 91 EISIHRSLAHQHVVGFHGFF-EDNDFVFVVLELCRRRSLLEL--HKRRKALTEPEARYYL 147 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKW 352 + +YL N +HRDL N+ ++ED K+ DFGL + + K+ + Sbjct: 148 RQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNY 207 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 APE L +K S + DVWS G +++ + G+ P+ LK+ R++K + P Sbjct: 208 IAPEVLSKKGHSFEVDVWSIGCIMYTLL-VGKPPFETSCLKETYLRIKKN-EYSIPKHIN 265 Query: 413 PAVYDVMKNCWHLDAATRPTFLQL 436 P +++ D RPT +L Sbjct: 266 PVAASLIQKMLQTDPTARPTINEL 289 >5G6V-A nrPDB Length = 324 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 99/200 (49%), Gaps = 13/200 (6%) Query: 198 LQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASVMTQLRHSNLVQLL 252 L +G+G + V G + N VA+K I+ + + E S++ L+H+N+V L Sbjct: 7 LDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 66 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 +I EK L +V EY+ K L YL G +++ + F + + Y +H Sbjct: 67 DIIHTEKS-LTLVFEYLDK-DLKQYLDDCG-NIINMHNVKLFLFQLLRGLAYCHRQKVLH 123 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALR-EKKFSTKSD 368 RDL +N+L++E K++DFGL + S T D + + + P+ L +ST+ D Sbjct: 124 RDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYSTQID 183 Query: 369 VWSFGILLWEIYSFGRVPYP 388 +W G + +E+ + GR +P Sbjct: 184 MWGVGCIFYEMAT-GRPLFP 202 >6GU6-A nrPDB Length = 302 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 104/207 (50%), Gaps = 27/207 (13%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLR 244 +M++ ++ IG+G +G V G ++ G VA+K I+ ++ + + E S++ +LR Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 64 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAME 303 H N+V L V++++ LY++ E+++ L YL S L+K L + + + Sbjct: 65 HPNIVSLQDVLMQD-SRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK----------WT 353 + +HRDL +N+L+ + K++DFGL + +P++ + Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG-------IPIRVYTHEVVTLWYR 175 Query: 354 APEALR-EKKFSTKSDVWSFGILLWEI 379 +PE L ++ST D+WS G + E+ Sbjct: 176 SPEVLLGSARYSTPVDIWSIGTIFAEL 202 >2BRG-A nrPDB Length = 297 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 100/210 (47%), Gaps = 21/210 (10%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATA---QAFLAEASVMTQLRHS 246 +++ L+QT+G+G +G+V L R + VAVK + + E + L H Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHE 65 Query: 247 NLVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+V+ G +G + Y+ EY + G L D R + +F + + YL Sbjct: 66 NVVKFYGH--RREGNIQYLFLEYCSGGELFD--RIEPDIGMPEPDAQRFFHQLMAGVVYL 121 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGL-------TKEASSTQDTGKLPVKWTAPEAL 358 G HRD+ N+L+ E + K+SDFGL +E + G LP + APE L Sbjct: 122 HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLP--YVAPELL 179 Query: 359 REKKFSTKS-DVWSFGILLWEIYSFGRVPY 387 + ++F + DVWS GI+L + + G +P+ Sbjct: 180 KRREFHAEPVDVWSCGIVLTAMLA-GELPW 208 >3GC9-A nrPDB Length = 370 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/244 (26%), Positives = 120/244 (49%), Gaps = 22/244 (9%) Query: 180 QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG-DYR-GNKVAVKCI----KNDATAQAF 233 + E ++ W + + L+ L+ +G G +G V D R KVAVK + ++ A+ Sbjct: 16 RQELNKTVWEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 74 Query: 234 LAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 E ++ L+H N++ LL V +E+ +Y+VT M L + ++S+ S Sbjct: 75 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG-ADLNNIVKSQALS---- 129 Query: 289 DCLLKFSL-DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK 347 D ++F + + ++Y+ +HRDL NV V+ED+ ++ DFGL ++A TG Sbjct: 130 DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEM-TGY 188 Query: 348 LPVKW-TAPE-ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM 405 + +W APE L ++ D+WS G ++ E+ G+ +P D + R+ + Sbjct: 189 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGT 247 Query: 406 DAPD 409 +P+ Sbjct: 248 PSPE 251 >2X4F-A nrPDB Length = 373 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/200 (30%), Positives = 95/200 (47%), Gaps = 17/200 (8%) Query: 199 QTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATA--QAFLAEASVMTQLRHSNLVQLLGV 254 + +G G FG V + G K+A K IK + E SVM QL H+NL+QL Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDA 154 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 E K + +V EY+ G L D + ++ D +L F +CE + ++ +H D Sbjct: 155 F-ESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTIL-FMKQICEGIRHMHQMYILHLD 212 Query: 315 LAARNVL-VSED-NVAKVSDFGLTKEASSTQDTGKLPV-----KWTAPEALREKKFSTKS 367 L N+L V+ D K+ DFGL + + KL V ++ APE + S + Sbjct: 213 LKPENILCVNRDAKQIKIIDFGLARRYKPRE---KLKVNFGTPEFLAPEVVNYDFVSFPT 269 Query: 368 DVWSFGILLWEIYSFGRVPY 387 D+WS G++ + + S G P+ Sbjct: 270 DMWSVGVIAYMLLS-GLSPF 288 >2BUJ-A nrPDB Length = 317 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/283 (22%), Positives = 128/283 (45%), Gaps = 31/283 (10%) Query: 190 LNMKELKLLQTIGKGEFG--DVMLGDYRGNKVAVK---CIKNDATAQAFLAEASVMTQLR 244 ++ K +Q +G+G F D++ G + G+ A+K C + +A EA + Sbjct: 26 IDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEA-QREADMHRLFN 84 Query: 245 HSNLVQLLGVIVEEKGG---LYIVTEYMAKGSL---VDYLRSRGRSVLGGDCLLKFSLDV 298 H N+++L+ + E+G +++ + +G+L ++ L+ +G + L D +L L + Sbjct: 85 HPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKG-NFLTEDQILWLLLGI 143 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL----------TKEASSTQD--TG 346 C +E + + HRDL N+L+ ++ + D G +++A + QD Sbjct: 144 CRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQ 203 Query: 347 KLPVKWTAPEALREKK---FSTKSDVWSFGILLWEIYSFGRVPYPRIPLK--DVVPRVEK 401 + + + APE + ++DVWS G +L+ + FG PY + K V V+ Sbjct: 204 RCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMM-FGEGPYDMVFQKGDSVALAVQN 262 Query: 402 GYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 + A++ ++ + +D RP L QLE ++ Sbjct: 263 QLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQ 305 >4AN9-A nrPDB Length = 301 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 99/216 (45%), Gaps = 15/216 (6%) Query: 228 ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 A + E V+ + +V G + G + I E+M GSL L+ GR + Sbjct: 49 AIRNQIIRELQVLHECNSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKKAGR--IP 105 Query: 288 GDCLLKFSLDVCEAMEYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG 346 L K S+ V + + YL E + +HRD+ N+LV+ K+ DFG++ + Sbjct: 106 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANE 165 Query: 347 KLPVK-WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM 405 + + + +PE L+ +S +SD+WS G+ L E+ + GR P P + + +++ + Sbjct: 166 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPRPPMAIFELLDYIVN---- 220 Query: 406 DAPDGCPPAVY-----DVMKNCWHLDAATRPTFLQL 436 + P P AV+ D + C + A R QL Sbjct: 221 EPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQL 256 >4AF3-A nrPDB Length = 292 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/274 (21%), Positives = 115/274 (41%), Gaps = 16/274 (5%) Query: 171 KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKC----- 223 KVME + D R + + ++ + +GKG+FG+V L + + VA+K Sbjct: 4 KVMENSSGTPDILTRH---FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ 60 Query: 224 IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR 283 I+ + E + L H N+++L + + +Y++ EY +G L Y + Sbjct: 61 IEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRR-IYLILEYAPRGEL--YKELQKS 117 Query: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-T 342 ++ +A+ Y G +HRD+ N+L+ K++DFG + A S Sbjct: 118 CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLR 177 Query: 343 QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 + T + + PE + + + K D+W G+L +E+ G P+ + R+ K Sbjct: 178 RKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELL-VGNPPFESASHNETYRRIVK- 235 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 + P P D++ + + R Q+ Sbjct: 236 VDLKFPASVPTGAQDLISKLLRHNPSERLPLAQV 269 >4M4Z-A nrPDB Length = 170 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/173 (32%), Positives = 84/173 (48%), Gaps = 21/173 (12%) Query: 10 SGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQKR 68 S +A +F +L G+ LTIV ++D +W+ ++V GRE IP+ +V K Sbjct: 10 SKATAVALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAK- 66 Query: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCE--- 123 V G W + ++RE+AE LL P G FL+RES G Y+L V Sbjct: 67 --VSHG-------WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPA 117 Query: 124 --GKVEHYRI-MYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVM 173 ++ HYRI L I + F +L LV+HY+ AD +C L +P V+ Sbjct: 118 SWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVL 170 >1V0B-A nrPDB Length = 288 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 107/219 (48%), Gaps = 17/219 (7%) Query: 192 MKELKLLQTIGKGEFGDVMLG-DYRGNKVAVKCIK----NDATAQAFLAEASVMTQLRHS 246 M++ L+ IG+G +G V + G A+K I+ ++ + E S++ +L+HS Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKG--SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 N+V+L VI K L +V E++ + L+D SV F L + + Y Sbjct: 61 NIVKLYDVI-HTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKS----FLLQLLNGIAY 115 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE--ASSTQDTGKLPVKW-TAPEALR-E 360 +HRDL +N+L++ + K++DFGL + + T ++ W AP+ L Sbjct: 116 CHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGS 175 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 KK+ST D+WS G + E+ + G +P + D + R+ Sbjct: 176 KKYSTTIDIWSVGCIFAEMVN-GAPLFPGVSEADQLMRI 213 >1KOA-A nrPDB Length = 491 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 94/201 (46%), Gaps = 15/201 (7%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCI--KNDATAQAFLAEASVMTQLRHSNLVQLL 252 + + +G G FG V R GN A K + +++ + E M+ LRH LV L Sbjct: 55 IHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTLVNLH 114 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 E+ + ++ E+M+ G L + + + + D +++ VC+ + ++ NN+VH Sbjct: 115 DAF-EDDNEMVMIYEFMSGGELFEKVADE-HNKMSEDEAVEYMRQVCKGLCHMHENNYVH 172 Query: 313 RDLAARNVLVS--EDNVAKVSDFGLTKEASSTQD----TGKLPVKWTAPEALREKKFSTK 366 DL N++ + N K+ DFGLT Q TG ++ APE K Sbjct: 173 LDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGT--AEFAAPEVAEGKPVGYY 230 Query: 367 SDVWSFGILLWEIYSFGRVPY 387 +D+WS G+L + + S G P+ Sbjct: 231 TDMWSVGVLSYILLS-GLSPF 250 >3UTO-A nrPDB Length = 573 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 94/201 (46%), Gaps = 15/201 (7%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCI--KNDATAQAFLAEASVMTQLRHSNLVQLL 252 + + +G G FG V R GN A K + +++ + E M+ LRH LV L Sbjct: 161 IHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTLVNLH 220 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 E+ + ++ E+M+ G L + + + + D +++ VC+ + ++ NN+VH Sbjct: 221 DAF-EDDNEMVMIYEFMSGGELFEKVADE-HNKMSEDEAVEYMRQVCKGLCHMHENNYVH 278 Query: 313 RDLAARNVLVS--EDNVAKVSDFGLTKEASSTQD----TGKLPVKWTAPEALREKKFSTK 366 DL N++ + N K+ DFGLT Q TG ++ APE K Sbjct: 279 LDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGT--AEFAAPEVAEGKPVGYY 336 Query: 367 SDVWSFGILLWEIYSFGRVPY 387 +D+WS G+L + + S G P+ Sbjct: 337 TDMWSVGVLSYILLS-GLSPF 356 >4CRS-A nrPDB Length = 341 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 101/218 (46%), Gaps = 26/218 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKN-DATAQ----AFLAEASV- 239 + N+++ + + +G FG V+L +Y+ A+K +K D A+ + + E + Sbjct: 7 FQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIF 66 Query: 240 --MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR----SRGRSVLGGDCLLK 293 + +RH LV L + K + V EY A G L+ ++ S R+V C Sbjct: 67 ETVNSVRHPFLVNLFACF-QTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAAC--- 122 Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PV 350 V ++YL + V+RDL N+L+ + K++DFGL KE D Sbjct: 123 ----VVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP 178 Query: 351 KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 ++ APE L E ++ D W G+L++E+ G P+P Sbjct: 179 EFLAPEVLTETSYTRAVDWWGLGVLIYEMLV-GESPFP 215 >3VN9-A nrPDB Length = 340 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 72/273 (26%), Positives = 123/273 (45%), Gaps = 26/273 (9%) Query: 187 GWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQA---FLAEASV-M 240 + + +L+ + +G+G +G V M G +AVK I+ +Q L + + M Sbjct: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS---RGRSVLGGDCLLKFSLD 297 + V G + E G ++I E M SL + + +G+++ D L K ++ Sbjct: 105 RTVDCPFTVTFYGALFRE-GDVWICMELM-DTSLDKFYKQVIDKGQTI-PEDILGKIAVS 161 Query: 298 VCEAMEYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKW 352 + +A+E+L + +HRD+ NVL++ K+ DFG L + T D G P + Sbjct: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--Y 219 Query: 353 TAPE----ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR--IPLKDVVPRVEKGYKMD 406 APE L +K +S KSD+WS GI + E+ + R PY P + + VE+ Sbjct: 220 MAPERINPELNQKGYSVKSDIWSLGITMIEL-AILRFPYDSWGTPFQQLKQVVEEPSPQL 278 Query: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 D D C ++ RPT+ +L + Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 >6CCF-A nrPDB Length = 290 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 48/160 (30%), Positives = 88/160 (55%), Gaps = 13/160 (8%) Query: 236 EASVMTQLRHSNLVQLLGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 E +++ +L H N+V+L+ V+ + + LY+V + + KG +++ + S L+ Sbjct: 78 EIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLR- 136 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQ--DTGKLPV 350 DV +EYL VHRD+ N+L+ +D K++DFG++ E + Q T P Sbjct: 137 --DVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPA 194 Query: 351 KWTAPEALRE--KKFSTKS-DVWSFGILLWEIYSFGRVPY 387 + APEA+ + + FS K+ DVW+ G+ L+ + +G+ P+ Sbjct: 195 -FMAPEAISDSGQSFSGKALDVWATGVTLY-CFVYGKCPF 232 >3OHT-A nrPDB Length = 389 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 65/249 (26%), Positives = 119/249 (47%), Gaps = 29/249 (11%) Query: 183 FYRSGWALNMKEL----KLLQTIGKGEFGDVMLG-DYR-GNKVAVKCI----KNDATAQA 232 FYR + E+ + L +G G +G V D + G K+AVK + ++ A+ Sbjct: 37 FYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKR 96 Query: 233 FLAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 E ++ ++H N++ LL V +EE +Y+VT M L + ++ + L Sbjct: 97 TYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMG-ADLNNIVKCQK---LT 152 Query: 288 GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK 347 D + + ++Y+ + +HRDL N+ V+ED K+ DFGL + + + TG Sbjct: 153 DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGY 211 Query: 348 LPVKW-TAPE-ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM 405 + +W APE L ++ D+WS G ++ E+ + GR +P D + ++++ ++ Sbjct: 212 VATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLT-GRTLFPGT---DHINQLQQIMRL 267 Query: 406 DAPDGCPPA 414 G PPA Sbjct: 268 ---TGTPPA 273 >4U41-A nrPDB Length = 332 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 49/204 (24%), Positives = 96/204 (47%), Gaps = 21/204 (10%) Query: 195 LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLR----HSNL 248 +L++ +G G +G V G + G A+K + D T + L+ H N+ Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDEEEEIKLEINMLKKYSHHRNI 83 Query: 249 VQLLGVIVEEK-----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 G +++ L++V E+ GS+ D +++ + L D + S ++ + Sbjct: 84 ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 143 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAPEALR- 359 +L ++ +HRD+ +NVL++E+ K+ DFG++ + T ++T W APE + Sbjct: 144 HLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 203 Query: 360 ----EKKFSTKSDVWSFGILLWEI 379 + + +SD+WS GI E+ Sbjct: 204 DENPDATYDYRSDLWSCGITAIEM 227 >4MVF-A nrPDB Length = 506 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 121/269 (44%), Gaps = 30/269 (11%) Query: 199 QTIGKGEFGDVMLG-DYRGNKV-AVKCIKND--ATAQAFLAEASVMTQLRHSNLVQLLGV 254 + +G+G +G V G D N++ A+K K D F E +M +L H N+V+L Sbjct: 63 EKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLYET 122 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 E +Y++ E + L D + G + ++K + A+ YL N VHR Sbjct: 123 -YENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMK---QIFSAIFYLHSLNIVHR 178 Query: 314 DLAARNVLV---SEDNVAKVSDFGLTKEASS---TQDTGKLPVKWTAPEALREKKFSTKS 367 DL N L ++D++ K+ DFGL+K + T P + AP+ L + K+ K Sbjct: 179 DLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPY-YVAPQVL-DGKYDKKC 236 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG----YKMDAPDGCPPA--------V 415 D+WS G++++ + G P+ +V+ +V+KG Y+ D A Sbjct: 237 DIWSSGVIMYTLLC-GYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLT 295 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHIR 444 Y+ + C +A P Q+ + EH+ Sbjct: 296 YNPNERCTIEEALNHPWITQMTKSHEHVE 324 >1UA2-A nrPDB Length = 346 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 99/208 (47%), Gaps = 18/208 (8%) Query: 193 KELKLLQTIGKGEFGDVMLG-DYRGNK-VAVKCIK-------NDATAQAFLAEASVMTQL 243 K + L +G+G+F V D N+ VA+K IK D + L E ++ +L Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H N++ LL K + +V ++M ++ + VL + + L + +E Sbjct: 70 SHPNIIGLLDAF-GHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKW-TAPEAL-R 359 YL + +HRDL N+L+ E+ V K++DFGL K S T ++ +W APE L Sbjct: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 + + D+W+ G +L E+ RVP+ Sbjct: 187 ARMYGVGVDMWAVGCILAEL--LLRVPF 212 >3FXW-A nrPDB Length = 336 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 53/190 (27%), Positives = 90/190 (47%), Gaps = 15/190 (7%) Query: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 Q +G G G V+ +R G K A+K + + A+ + + H +V +L V Sbjct: 35 QVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPH--IVCILDVYE 92 Query: 257 EEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 G L I+ E M G L ++ RG + D+ A+++L +N HR Sbjct: 93 NMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHR 152 Query: 314 DLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALREKKFSTKS 367 D+ N+L + +D V K++DFG KE +TQ+ + P + APE L +K+ Sbjct: 153 DVKPENLLYTSKEKDAVLKLTDFGFAKE--TTQNALQTPCYTPYYVAPEVLGPEKYDKSC 210 Query: 368 DVWSFGILLW 377 D+WS G++++ Sbjct: 211 DMWSLGVIMY 220 >2QLU-A nrPDB Length = 314 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 72/299 (24%), Positives = 133/299 (44%), Gaps = 55/299 (18%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQ--LRHSNLVQLL 252 L+LL+ +G FG V + VAVK I Q++ +E + + ++H NL+Q + Sbjct: 17 LQLLEIKARGRFGCVWKAQLMNDFVAVK-IFPLQDKQSWQSEREIFSTPGMKHENLLQFI 75 Query: 253 GVIVEEKGG-----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL-- 305 E++G L+++T + KGSL DYL+ +++ + L + + + YL Sbjct: 76 AA--EKRGSNLEVELWLITAFHDKGSLTDYLKG---NIITWNELCHVAETMSRGLSYLHE 130 Query: 306 -------EGN--NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-----PVK 351 EG+ + HRD ++NVL+ D A ++DFGL + G + Sbjct: 131 DVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRR 190 Query: 352 WTAPEALR-----EKKFSTKSDVWSFGILLWEIYSF-----GRVPYPRIPLKDVV---PR 398 + APE L ++ + D+++ G++LWE+ S G V +P ++ + P Sbjct: 191 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPS 250 Query: 399 VEKGYKMDAPDGCPPAVYD-------------VMKNCWHLDAATRPTFLQLREQLEHIR 444 +E+ ++ P + D ++ CW DA R + + E++ IR Sbjct: 251 LEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIR 309 >2WTK-C nrPDB Length = 305 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 99/214 (46%), Gaps = 15/214 (7%) Query: 236 EASVMTQLRHSNLVQLLGVIV-EEKGGLYIVTEYMAKG--SLVDYLRSRGRSVLGGDCLL 292 E ++ +LRH N++QL+ V+ EEK +Y+V EY G ++D + + V Sbjct: 56 EIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAH--- 112 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGK 347 + + + +EYL VH+D+ N+L++ K+S G+ + A T T + Sbjct: 113 GYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ 172 Query: 348 LPVKWTAPE-ALREKKFST-KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM 405 + PE A FS K D+WS G+ L+ I + G P+ + + + KG Sbjct: 173 GSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITT-GLYPFEGDNIYKLFENIGKG-SY 230 Query: 406 DAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 P C P + D++K + A R + Q+R+ Sbjct: 231 AIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH 264 >3FME-A nrPDB Length = 290 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 71/266 (26%), Positives = 121/266 (45%), Gaps = 26/266 (9%) Query: 194 ELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQA---FLAEASV-MTQLRHSN 247 +L+ + +G+G +G V M G +AVK I+ +Q L + + M + Sbjct: 8 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 67 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS---RGRSVLGGDCLLKFSLDVCEAMEY 304 V G + E G ++I E M SL + + +G+++ D L K ++ + +A+E+ Sbjct: 68 TVTFYGALFRE-GDVWICMELM-DTSLDKFYKQVIDKGQTI-PEDILGKIAVSIVKALEH 124 Query: 305 LEGN-NFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTAPE--- 356 L + +HRD+ NVL++ K+ DFG L + + D G P + APE Sbjct: 125 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKP--YMAPERIN 182 Query: 357 -ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR--IPLKDVVPRVEKGYKMDAPDGCPP 413 L +K +S KSD+WS GI + E+ + R PY P + + VE+ D Sbjct: 183 PELNQKGYSVKSDIWSLGITMIEL-AILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA 241 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQ 439 D C ++ RPT+ +L + Sbjct: 242 EFVDFTSQCLKKNSKERPTYPELMQH 267 >4I94-A nrPDB Length = 300 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 50/173 (28%), Positives = 87/173 (50%), Gaps = 7/173 (4%) Query: 218 KVAVKCIKNDA--TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLV 275 ++AVK + ++ FL EA + QLR+ + LLG E++ L ++ E+M +L Sbjct: 55 RIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERL-LIAEFMPNETLA 113 Query: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYL--EGNNFVHRDLAARNVLVSEDNVAKVSDF 333 +L + L+ +L + +A+EY +G H DL A VL +D ++S F Sbjct: 114 KHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYH-DLNAYRVLFDDDANPRLSCF 172 Query: 334 GLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP 386 GL K + + + +T PE LR + + +S ++SFG LL ++ S +P Sbjct: 173 GLMKNSRDGKSYST-NLAFTPPEYLRTGRVTPESVIYSFGTLLLDLLSGKHIP 224 >5X8I-B nrPDB Length = 346 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/246 (26%), Positives = 107/246 (43%), Gaps = 33/246 (13%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVM-LGDYR--GNKVAVKCIKN-DATAQAFLAEASVM 240 +SG L+ + +++ T+G+G FG V+ D++ G VAVK +KN D +A +E V+ Sbjct: 6 QSGDVLSAR-YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVL 64 Query: 241 TQLRHSN------LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 L ++ VQ+L E G + IV E + S D+++ G D + K Sbjct: 65 EHLNTTDPNSTFRCVQMLEWF-EHHGHICIVFELLGL-STYDFIKENGFLPFRLDHIRKM 122 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA-------------------KVSDFGL 335 + +C+++ +L N H DL N+L + + KV DFG Sbjct: 123 AYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGS 182 Query: 336 TKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 T + APE + +S DVWS G +L E Y G +P K+ Sbjct: 183 ATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY-LGFTVFPTHDSKEH 241 Query: 396 VPRVEK 401 + +E+ Sbjct: 242 LAMMER 247 >4EWQ-A nrPDB Length = 383 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 98/204 (48%), Gaps = 19/204 (9%) Query: 198 LQTIGKGEFGDV--MLGDYRGNKVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQL 251 L +G G +G V G +VAVK + ++ A+ E ++ ++H N++ L Sbjct: 50 LSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 109 Query: 252 LGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 L V +EE +Y+VT M L + ++ + L D + + ++Y+ Sbjct: 110 LDVFTPARSLEEFNDVYLVTHLMG-ADLNNIVKCQK---LTDDHVQFLIYQILRGLKYIH 165 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW-TAPE-ALREKKFS 364 + +HRDL N+ V+ED K+ DFGL + + + TG + +W APE L ++ Sbjct: 166 SADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVATRWYRAPEIMLNWMHYN 224 Query: 365 TKSDVWSFGILLWEIYSFGRVPYP 388 D+WS G ++ E+ + GR +P Sbjct: 225 QTVDIWSVGCIMAELLT-GRTLFP 247 >5D7A-A nrPDB Length = 308 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 46/202 (22%), Positives = 94/202 (46%), Gaps = 17/202 (8%) Query: 195 LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQ--LRHSNLVQ 250 +L++ +G G +G V G + G A+K + + + + M + H N+ Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 251 LLGVIVEEK-----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 G +++ L++V E+ GS+ D +++ + L + + ++ + +L Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAPEALR--- 359 + +HRD+ +NVL++E+ K+ DFG++ + T ++T W APE + Sbjct: 139 HQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDE 198 Query: 360 --EKKFSTKSDVWSFGILLWEI 379 + + KSD+WS GI E+ Sbjct: 199 NPDATYDFKSDLWSLGITAIEM 220 >5KKR-C nrPDB Length = 395 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/163 (28%), Positives = 80/163 (49%), Gaps = 6/163 (3%) Query: 228 ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 A + E V+ + +V G + G + I E+M GSL L+ GR + Sbjct: 108 AIRNQIIRELQVLHECNSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKKAGR--IP 164 Query: 288 GDCLLKFSLDVCEAMEYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG 346 L K S+ V + + YL E + +HRD+ N+LV+ K+ DFG++ + + Sbjct: 165 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS 224 Query: 347 KLPVK-WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 + + + +PE L+ +S +SD+WS G+ L E+ + GR P P Sbjct: 225 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 266 >3EQC-A nrPDB Length = 360 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/163 (28%), Positives = 80/163 (49%), Gaps = 6/163 (3%) Query: 228 ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 A + E V+ + +V G + G + I E+M GSL L+ GR + Sbjct: 73 AIRNQIIRELQVLHECNSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKKAGR--IP 129 Query: 288 GDCLLKFSLDVCEAMEYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG 346 L K S+ V + + YL E + +HRD+ N+LV+ K+ DFG++ + + Sbjct: 130 EQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS 189 Query: 347 KLPVK-WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 + + + +PE L+ +S +SD+WS G+ L E+ + GR P P Sbjct: 190 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIP 231 >6BFN-A nrPDB Length = 342 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 96/208 (46%), Gaps = 25/208 (12%) Query: 201 IGKGEFGDVMLGDYRGNKVAVKCIKNDA------TAQAFLAEASVMTQLRHSNLVQLLGV 254 IG+G FG V R AVK +K +A Q+FL E +++ RH N+V G Sbjct: 30 IGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGY 89 Query: 255 IVEEKGGLY-IVTEYMAKGSLVDYLRSRGRSV--LGGDCLLKFSLDVCEAMEYL--EGNN 309 + G Y +V ++ GSL D L + ++ L L L A+++L + + Sbjct: 90 CAQN--GFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPS 147 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQD-------TGKLPVKWTAPEA 357 +H D+ + NVL+ E K+ DFGL + +S +Q T + + + E Sbjct: 148 LIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 207 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRV 385 ++ + + +D +SFG+++ E + R Sbjct: 208 IKTGRLAVDTDTFSFGVVVLETLAGQRA 235 >4AU8-A nrPDB Length = 296 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 109/228 (47%), Gaps = 27/228 (11%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK----NDATAQAFLAEASVMTQ 242 A+ ++ + L+ IG+G +G V R VA+K ++ ++ + L E ++ + Sbjct: 2 AMGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKE 61 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L+H N+V+L V+ +K L +V E+ + L Y S L + + F + + + Sbjct: 62 LKHKNIVRLHDVLHSDKK-LTLVFEFCDQ-DLKKYFDS-CNGDLDPEIVKSFLFQLLKGL 118 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK----------W 352 + N +HRDL +N+L++ + K++DFGL + +PV+ + Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG-------IPVRCYSAEVVTLWY 171 Query: 353 TAPEALREKK-FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 P+ L K +ST D+WS G + E+ + GR +P + D + R+ Sbjct: 172 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 219 >4M69-B nrPDB Length = 283 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/260 (22%), Positives = 114/260 (43%), Gaps = 24/260 (9%) Query: 204 GEFGDVMLGDYRGNKVAVKCIKNDATAQ------AFLAEASVMTQLRHSNLVQLLGVIVE 257 + + G+Y + V +K N F E M + N++++ G+ ++ Sbjct: 20 SKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICID 79 Query: 258 EK---GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + IV EY G+L + L + LL L + L + +HR+ Sbjct: 80 QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL--VLRAARGLYRLHHSETLHRN 137 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-------PVKWTAPEALREK--KFST 365 +++ + LV+ K++ F L+K +S T K + +PE L+ + Sbjct: 138 ISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDI 197 Query: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG--CPPAVYDVMKNCW 423 K++++SFGI+LWEI + G++P+ K + V + K + P G CP + +++ C Sbjct: 198 KAEIYSFGIVLWEIAT-GKIPFEGCDSKKIRELVAEDKKQE-PVGQDCPELLREIINECR 255 Query: 424 HLDAATRPTFLQLREQLEHI 443 + + RP+ + E+L + Sbjct: 256 AHEPSQRPSVDGILERLSAV 275 >4KIK-B nrPDB Length = 677 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 91/209 (43%), Gaps = 26/209 (12%) Query: 201 IGKGEFGDVML--GDYRGNKVAVKCIKNDATA---QAFLAEASVMTQLRHSNLVQLLGVI 255 +G G FG+V+ G ++A+K + + + + + E +M +L H N+V V Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDV- 85 Query: 256 VEEKGGL------YIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGN 308 E L + EY G L YL L +L D+ A+ YL N Sbjct: 86 PEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHEN 145 Query: 309 NFVHRDLAARNVLVSEDN---VAKVSDFGLTKEASSTQDTGKL------PVKWTAPEALR 359 +HRDL N+++ + + K+ D G KE D G L +++ APE L Sbjct: 146 RIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKEL----DQGSLCTSFVGTLQYLAPELLE 201 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 ++K++ D WSFG L +E + R P Sbjct: 202 QQKYTVTVDYWSFGTLAFECITGFRPFLP 230 >2VN9-A nrPDB Length = 301 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 67/257 (26%), Positives = 113/257 (43%), Gaps = 25/257 (9%) Query: 194 ELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATA----QAFLAEASVMTQLRHSN 247 E +L + +GKG F V + G + A K I + Q EA + L+H N Sbjct: 5 EYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPN 64 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYL 305 +V+L I EE G Y+V + + G L + + +R C+ + + E++ + Sbjct: 65 IVRLHDSISEE-GFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQ----ILESVNHC 119 Query: 306 EGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEAL 358 N VHRDL N+L+ S+ K++DFGL E Q P + +PE L Sbjct: 120 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTP-GYLSPEVL 178 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAV 415 R+ + D+W+ G++L+ I G P+ + +++ G Y +P D P Sbjct: 179 RKDPYGKPVDMWACGVILY-ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 237 Query: 416 YDVMKNCWHLDAATRPT 432 D++ ++ A R T Sbjct: 238 KDLINKMLTINPAKRIT 254 >4JG6-A nrPDB Length = 355 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 21/204 (10%) Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD-YLRSRGRSVLGGDCLLKFSLDVCEAM 302 +H N++ L V + K +Y+VTE M G L+D LR + S +L + + + Sbjct: 87 QHPNIITLKDVYDDGKY-VYVVTELMKGGELLDKILRQKFFSEREASAVL---FTITKTV 142 Query: 303 EYLEGNNFVHRDLAARNVLVSEDN----VAKVSDFGLTKEASSTQDTGKLP---VKWTAP 355 EYL VHRDL N+L +++ ++ DFG K+ + P + AP Sbjct: 143 EYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAP 202 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP---LKDVVPRVEKGYKMDAPDGCP 412 E L + + D+WS G+LL+ + + G P+ P ++++ R+ G K G Sbjct: 203 EVLERQGYDAACDIWSLGVLLYTMLT-GYTPFANGPDDTPEEILARIGSG-KFSLSGGYW 260 Query: 413 PAVYDVMKNC----WHLDAATRPT 432 +V D K+ H+D R T Sbjct: 261 NSVSDTAKDLVSKMLHVDPHQRLT 284 >1S9I-A nrPDB Length = 354 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 47/163 (28%), Positives = 79/163 (48%), Gaps = 6/163 (3%) Query: 228 ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 A + E V+ + +V G + G + I E+M GSL L+ R + Sbjct: 56 AIRNQIIRELQVLHECNSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKEAKR--IP 112 Query: 288 GDCLLKFSLDVCEAMEYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG 346 + L K S+ V + YL E + +HRD+ N+LV+ K+ DFG++ + + Sbjct: 113 EEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS 172 Query: 347 KLPVK-WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 + + + APE L+ +S +SD+WS G+ L E+ + GR P P Sbjct: 173 FVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVEL-AVGRYPIP 214 >4OW8-A nrPDB Length = 283 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 97/211 (45%), Gaps = 26/211 (12%) Query: 196 KLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATA-----QAFLAEASVMTQLRHSNL 248 +L + I G G V + + G +VAVK +K++ ++ + F AEA L H + Sbjct: 14 RLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGI 73 Query: 249 VQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE---- 300 + + G Y+V E + L L+ GR L+ +LD+ E Sbjct: 74 ASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR------LSLRHALDMLEQTGR 127 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDTGKL--PVKWTAPE 356 A++ VHRD+ N+L++ K++DFG+ K +A+ TG + ++ APE Sbjct: 128 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 187 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 S SDV+S G++ +E S G+ P+ Sbjct: 188 QALGHDASPASDVYSLGVVGYEAVS-GKRPF 217 >4O2Z-A nrPDB Length = 377 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 75/280 (26%), Positives = 119/280 (42%), Gaps = 48/280 (17%) Query: 197 LLQTIGKGEFG---DVMLGDYRGNKVAVK----CIKNDATAQAFLAEASVMTQLRHSNLV 249 LL+ +G G +G + GD G KV++K ++ + L E +M H NL+ Sbjct: 49 LLKILGMGAYGIACSCLDGD-TGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLL 107 Query: 250 QLLGVIVEEKG------GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 ++ ++ K +Y+VT M V LRSR VL + F + ++ Sbjct: 108 NVVNILPPLKREYHSFEDVYVVTPLMDVDMNV-VLRSR--QVLEESHMQYFVYQILRGLK 164 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDTGKLPVKW-TAPEALRE 360 YL N HRDL N++ + K+ DFGL++ + ++ T + +W PE L E Sbjct: 165 YLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLE 224 Query: 361 K-KFSTKSDVWSFGILLWEIYSF-----GRVPYPRI---------PLKDVVPRVEKGYKM 405 +ST D+WS G + E+Y+ GR ++ P +V E K+ Sbjct: 225 NTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEKL 284 Query: 406 DA-PDGC---PPAV---------YDVMKNCWHLDAATRPT 432 + PDG P V D + W LD + RPT Sbjct: 285 NELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPT 324 >4BTF-A nrPDB Length = 469 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 58/252 (23%), Positives = 112/252 (44%), Gaps = 24/252 (9%) Query: 212 GDYRGNKVAVKCIKNDATAQ------AFLAEASVMTQLRHSNLVQLLGVIVEEK---GGL 262 G+Y + V +K N F E M + N++++ G+ +++ Sbjct: 214 GEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEF 273 Query: 263 YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV 322 IV EY G+L + L + LL L + L + +HR++++ + LV Sbjct: 274 SIVMEYCELGTLRELLDREKDLTMSVRSLL--VLRAARGLYRLHHSETLHRNISSSSFLV 331 Query: 323 SEDNVAKVSDFGLTKEASSTQDTGKL-------PVKWTAPEALREK--KFSTKSDVWSFG 373 + K++ F L+K +S T K + +PE L+ + K++++SFG Sbjct: 332 AGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFG 391 Query: 374 ILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG--CPPAVYDVMKNCWHLDAATRP 431 I+LWEI + G++P+ K + V + K + P G CP + +++ C + + RP Sbjct: 392 IVLWEIAT-GKIPFEGCDSKKIRELVAEDKKQE-PVGQDCPELLREIINECRAHEPSQRP 449 Query: 432 TFLQLREQLEHI 443 + + E+L + Sbjct: 450 SVDGILERLSAV 461 >5AR8-A nrPDB Length = 326 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 132/292 (45%), Gaps = 47/292 (16%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKN-----DATAQAFLAEASVMTQLRHS 246 + +L+ L G D+R +VAVK + D+ + L EA ++ + R S Sbjct: 34 LADLRYLSRGASGTVSSARHADWRV-QVAVKHLHIHTPLLDSERKDVLREAEILHKARFS 92 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL--DVCEAMEY 304 ++ +LG I E L IVTEYM GSL + L R L+F + ++ + Y Sbjct: 93 YILPILG-ICNEPEFLGIVTEYMPNGSLNELLH-RKTEYPDVAWPLRFRILHEIALGVNY 150 Query: 305 LEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLP----VKWTA 354 L +H DL +N+L+ + K++DFGL+K S ++ + P + + Sbjct: 151 LHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMP 210 Query: 355 PEAL---REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC 411 PE ++ + S K D++S+ ++ WE+ S + P +DV ++ Y + G Sbjct: 211 PENYEPGQKSRASIKHDIYSYAVITWEVLSRKQ------PFEDVTNPLQIMYSVS--QGH 262 Query: 412 PPAV------YDV---------MKNCWHLDAATRPTFLQLREQLEHI-RTHE 447 P + YD+ +++ W + RP+FL+ +LE + RT E Sbjct: 263 RPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFE 314 >6CQF-A nrPDB Length = 297 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 99/221 (44%), Gaps = 19/221 (8%) Query: 197 LLQTIGKGEFGDVMLG--DYRGNKVAVKCIK--NDATAQAFLAEASVMTQLRHSNLVQLL 252 LLQ +G G +G+V G+ VA+K +K D E ++ RH+N+V Sbjct: 20 LLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYH 79 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL---DVCEAMEYLEGNN 309 G + + L+I E+ GSL D + V G L+ S +V + + YL Sbjct: 80 GSYLWLQK-LWICMEFCGAGSLQDIYQ-----VTGSLSELQISYVCREVLQGLAYLHSQK 133 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK---WTAPEALR---EKKF 363 +HRD+ N+L+++ +++DFG++ + +T + W APE + + Sbjct: 134 KIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGY 193 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404 + D+WS GI E+ + PL+ + + GY+ Sbjct: 194 NELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQ 234 >1KOB-A nrPDB Length = 387 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/269 (21%), Positives = 115/269 (42%), Gaps = 41/269 (15%) Query: 197 LLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLA----------------EASVM 240 +L+ +G G FG V +C++ AT + F+A E S+M Sbjct: 55 ILEELGSGAFG-----------VVHRCVEK-ATGRVFVAKFINTPYPLDKYTVKNEISIM 102 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 QL H L+ L E+K + ++ E+++ G L D + + + + ++ + CE Sbjct: 103 NQLHHPKLINLHDAF-EDKYEMVLILEFLSGGELFDRIAAEDYKMSEAE-VINYMRQACE 160 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVA--KVSDFGLTKEASSTQ--DTGKLPVKWTAPE 356 ++++ ++ VH D+ N++ + K+ DFGL + + + ++ APE Sbjct: 161 GLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPE 220 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYP---RIPLKDVVPRVEKGYKMDAPDGCPP 413 + + +D+W+ G+L + + S G P+ + V R + + DA P Sbjct: 221 IVDREPVGFYTDMWAIGVLGYVLLS-GLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSP 279 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQLEH 442 D +KN + R L + + LEH Sbjct: 280 EAKDFIKNLLQKEPRKR---LTVHDALEH 305 >4NIF-A nrPDB Length = 333 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 66/259 (25%), Positives = 116/259 (44%), Gaps = 26/259 (10%) Query: 199 QTIGKGEFGDVMLGDYRGNKV--AVKCIKNDATAQAFLAEASVMTQL-RHSNLVQLLGVI 255 +TIG G + + ++ + AVK I D + + E ++ + +H N++ L V Sbjct: 14 ETIGVGSYSECKRCVHKATNMEYAVKVI--DKSKRDPSEEIEILLRYGQHPNIITLKDVY 71 Query: 256 VEEKGGLYIVTEYMAKGSLVD-YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + K +Y+VTE M G L+D LR + S +L + + +EYL VHRD Sbjct: 72 DDGKH-VYLVTELMRGGELLDKILRQKFFSEREASFVLH---TIGKTVEYLHSQGVVHRD 127 Query: 315 LAARNVLVSEDN----VAKVSDFGLTKEASSTQDTGKLP---VKWTAPEALREKKFSTKS 367 L N+L +++ ++ DFG K+ + P + APE L+ + + Sbjct: 128 LKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGC 187 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPL---KDVVPRVEKGYKMDAPDG----CPPAVYDVMK 420 D+WS GILL+ + + G P+ P ++++ R+ G K G D++ Sbjct: 188 DIWSLGILLYTMLA-GYTPFANGPSDTPEEILTRIGSG-KFTLSGGNWNTVSETAKDLVS 245 Query: 421 NCWHLDAATRPTFLQLREQ 439 H+D R T Q+ + Sbjct: 246 KMLHVDPHQRLTAKQVLQH 264 >4X3F-A nrPDB Length = 337 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 97/211 (45%), Gaps = 26/211 (12%) Query: 196 KLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATA-----QAFLAEASVMTQLRHSNL 248 +L + I G G V + + G +VAVK +K++ ++ + F AEA L H + Sbjct: 15 RLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGI 74 Query: 249 VQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE---- 300 + + G Y+V E + L L+ GR L+ +LD+ E Sbjct: 75 ASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR------LSLRHALDMLEQTGR 128 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDTGKL--PVKWTAPE 356 A++ VHRD+ N+L++ K++DFG+ K +A+ TG + ++ APE Sbjct: 129 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 188 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 S SDV+S G++ +E S G+ P+ Sbjct: 189 QALGHDASPASDVYSLGVVGYEAVS-GKRPF 218 >6B2Q-A nrPDB Length = 317 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 97/211 (45%), Gaps = 26/211 (12%) Query: 196 KLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATA-----QAFLAEASVMTQLRHSNL 248 +L + I G G V + + G +VAVK +K++ ++ + F AEA L H + Sbjct: 35 RLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGI 94 Query: 249 VQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE---- 300 + + G Y+V E + L L+ GR L+ +LD+ E Sbjct: 95 ASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR------LSLRHALDMLEQTGR 148 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDTGKL--PVKWTAPE 356 A++ VHRD+ N+L++ K++DFG+ K +A+ TG + ++ APE Sbjct: 149 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 208 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 S SDV+S G++ +E S G+ P+ Sbjct: 209 QALGHDASPASDVYSLGVVGYEAVS-GKRPF 238 >3SOC-A nrPDB Length = 322 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 103/213 (48%), Gaps = 31/213 (14%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK-NDATAQAFLAEASVMTQLRHSNLVQLLG 253 L+LL+ +G FG V VAVK D + E + ++H N++Q +G Sbjct: 26 LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG 85 Query: 254 VIVEEKG-----GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 E++G L+++T + KGSL D+L++ +V+ + L + + + YL + Sbjct: 86 A--EKRGTSVDVDLWLITAFHEKGSLSDFLKA---NVVSWNELCHIAETMARGLAYLHED 140 Query: 309 ----------NFVHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDT-GKLPV-KWT 353 HRD+ ++NVL+ + A ++DFGL + S DT G++ ++ Sbjct: 141 IPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYM 200 Query: 354 APEALR-----EKKFSTKSDVWSFGILLWEIYS 381 APE L ++ + D+++ G++LWE+ S Sbjct: 201 APEVLEGAINFQRDAFLRIDMYAMGLVLWELAS 233 >3BHH-A nrPDB Length = 295 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 70/267 (26%), Positives = 119/267 (44%), Gaps = 28/267 (10%) Query: 194 ELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATA----QAFLAEASVMTQLRHSN 247 E +L + IGKG F V + G++ A K I + Q EA + L+HSN Sbjct: 5 EYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSN 64 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYL 305 +V+L I EE G Y+V + + G L + + +R C+ + + EA+ + Sbjct: 65 IVRLHDSISEE-GFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQ----ILEAVLHC 119 Query: 306 EGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEAL 358 VHRDL N+L++ + K++DFGL E Q P + +PE L Sbjct: 120 HQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTP-GYLSPEVL 178 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAV 415 R++ + D+W+ G++L+ I G P+ + +++ G Y +P D P Sbjct: 179 RKEAYGKPVDIWACGVILY-ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEA 237 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEH 442 +++ ++ A R T E L+H Sbjct: 238 KNLINQMLTINPAKRIT---AHEALKH 261 >2YCR-A nrPDB Length = 323 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 67/223 (30%), Positives = 100/223 (44%), Gaps = 31/223 (13%) Query: 199 QTIGKGEFGDVMLGDYRGN--KVAVKCIKNDATAQAFLAEAS----------VMTQLRHS 246 +T+G G G+V L R KVA+K I A EA ++ +L H Sbjct: 16 KTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHP 75 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 ++++ E YIV E M G L D + R + C L F + A++YL Sbjct: 76 CIIKIKNFFDAE--DYYIVLELMEGGELFDKVVGNKR-LKEATCKLYF-YQMLLAVQYLH 131 Query: 307 GNNFVHRDLAARNVLVS---EDNVAKVSDFGLTK---EASSTQDTGKLPVKWTAPEALRE 360 N +HRDL NVL+S ED + K++DFG +K E S + P + APE L Sbjct: 132 ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT-YLAPEVLVS 190 Query: 361 ---KKFSTKSDVWSFGILLWEIYSFGRVPYP----RIPLKDVV 396 ++ D WS G++L+ S G P+ ++ LKD + Sbjct: 191 VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQI 232 >2WTK-B nrPDB Length = 373 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 101/219 (46%), Gaps = 28/219 (12%) Query: 196 KLLQTIGKGEFGDVM---LGDYR--GNKVAVKCIKNDATAQ---AFL-AEASVMTQLRHS 246 +LL IGKG F D+M L Y+ G V V+ I +A + FL E V H Sbjct: 12 ELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V + + L++VT +MA GS D + + + + V +A++Y+ Sbjct: 71 NIVPYRATFIADNE-LWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIH 129 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---------TQDTGKLPVK---WTA 354 +VHR + A ++L+S D KV GL S D K VK W + Sbjct: 130 HMGYVHRSVKASHILISVD--GKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLS 187 Query: 355 PEALRE--KKFSTKSDVWSFGILLWEIYSFGRVPYPRIP 391 PE L++ + + KSD++S GI E+ + G VP+ +P Sbjct: 188 PEVLQQNLQGYDAKSDIYSVGITACELAN-GHVPFKDMP 225 >3QD2-B nrPDB Length = 332 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 43/140 (30%), Positives = 69/140 (49%), Gaps = 19/140 (13%) Query: 262 LYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARN 319 LYI + K +L D++ R G CL F + + EA+E+L +HRDL N Sbjct: 136 LYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIF-IQIAEAVEFLHSKGLMHRDLKPSN 194 Query: 320 VLVSEDNVAKVSDFGLTKEASSTQD--------------TGKLPVK-WTAPEALREKKFS 364 + + D+V KV DFGL ++ TG++ K + +PE + +S Sbjct: 195 IFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYS 254 Query: 365 TKSDVWSFGILLWE-IYSFG 383 K D++S G++L+E +YSF Sbjct: 255 HKVDIFSLGLILFELLYSFS 274 >3NYO-A nrPDB Length = 576 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 90/198 (45%), Gaps = 11/198 (5%) Query: 199 QTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAF-------LAEASVMTQLRHSNLVQL 251 + +GKG FG+V R C K + L E ++ ++ +S V Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVS 248 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 L E K L +V M G L ++ G++ + ++ ++C +E L V Sbjct: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 Query: 312 HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT-GKL-PVKWTAPEALREKKFSTKSDV 369 +RDL N+L+ + ++SD GL Q G++ V + APE ++ ++++ D Sbjct: 309 YRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368 Query: 370 WSFGILLWEIYSFGRVPY 387 W+ G LL+E+ + G+ P+ Sbjct: 369 WALGCLLYEMIA-GQSPF 385 >4YHJ-A nrPDB Length = 584 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 91/217 (41%), Gaps = 9/217 (4%) Query: 199 QTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFL-AEASVMTQLR-----HSNLVQLL 252 + +GKG FG+V R C K EA + + R S V L Sbjct: 191 RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSL 250 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 E K L +V M G L ++ + G + ++ ++C +E L+ V+ Sbjct: 251 AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVY 310 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT-GKL-PVKWTAPEALREKKFSTKSDVW 370 RDL N+L+ + ++SD GL E Q G++ V + APE + +K++ D W Sbjct: 311 RDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWW 370 Query: 371 SFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA 407 G L++E+ G P+ + K V++ K D Sbjct: 371 GLGCLIYEMIQ-GHSPFKKYKEKVKWEEVDQRIKNDT 406 >5TQX-A nrPDB Length = 655 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/199 (25%), Positives = 91/199 (45%), Gaps = 23/199 (11%) Query: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA---QAFLAEASVMTQLRHSNLVQLLG 253 + +G G FG+V L +R K+A+K + + + + + E +M +L H+N+V+ Sbjct: 14 ERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACD 73 Query: 254 VIVEEKGGLY----IVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGN 308 V E ++ + EY + G L L L +L D+ + YL N Sbjct: 74 VPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHEN 133 Query: 309 NFVHRDLAARNVLVSEDN---VAKVSDFGLTKEASSTQDTGKL------PVKWTAPEALR 359 +HRDL N+++ + + K+ D G K+ D G+L +++ APE Sbjct: 134 KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDV----DQGELCTEFVGTLQYLAPELFE 189 Query: 360 EKKFSTKSDVWSFGILLWE 378 K ++ D WSFG +++E Sbjct: 190 NKPYTATVDYWSFGTMVFE 208 >1VZO-A nrPDB Length = 355 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 101/221 (45%), Gaps = 32/221 (14%) Query: 190 LNMKELKLLQTIGKGEFGDVML-----GDYRGNKVAVKCIKNDA------TAQAFLAEAS 238 + ++ +LL+ +G G +G V L G G A+K +K T + E Sbjct: 51 VGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQ 110 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR------SVLGGDCLL 292 V+ +R S + L + + L+++ +Y+ G L +L R R + G+ +L Sbjct: 111 VLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVL 170 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE--ASSTQDTGKL-- 348 A+E+L ++RD+ N+L+ + ++DFGL+KE A T+ Sbjct: 171 --------ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCG 222 Query: 349 PVKWTAPEALR--EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 +++ AP+ +R + D WS G+L++E+ + G P+ Sbjct: 223 TIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLT-GASPF 262 >2W96-B nrPDB Length = 306 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 49/195 (25%), Positives = 90/195 (46%), Gaps = 16/195 (8%) Query: 201 IGKGEFGDVMLG--DYRGNKVAVKCIK----NDATAQAFLAEASVMTQLR---HSNLVQL 251 IG G +G V + G+ VA+K ++ + + + E +++ +L H N+V+L Sbjct: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNVVRL 71 Query: 252 LGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 + V + + +V E++ + L YL L + + +++L Sbjct: 72 MDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHA 130 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKKFST 365 N VHRDL N+LV+ K++DFGL + S + V + APE L + ++T Sbjct: 131 NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLLQSTYAT 190 Query: 366 KSDVWSFGILLWEIY 380 D+WS G + E++ Sbjct: 191 PVDMWSVGCIFAEMF 205 >3I6U-A nrPDB Length = 419 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 67/228 (29%), Positives = 102/228 (44%), Gaps = 31/228 (13%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCIKNDATAQAFLAEAS----------VMT 241 E + +T+G G G+V L R KVA++ I A EA ++ Sbjct: 136 EYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILK 195 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +L H ++++ E YIV E M G L D + R + C L F + A Sbjct: 196 KLNHPCIIKIKNFFDAE--DYYIVLELMEGGELFDKVVGNKR-LKEATCKLYF-YQMLLA 251 Query: 302 MEYLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTK---EASSTQDTGKLPVKWTAP 355 ++YL N +HRDL NVL+S ED + K++DFG +K E S + P + AP Sbjct: 252 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT-YLAP 310 Query: 356 EALRE---KKFSTKSDVWSFGILLWEIYSFGRVPYP----RIPLKDVV 396 E L ++ D WS G++L+ S G P+ ++ LKD + Sbjct: 311 EVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQI 357 >3QA8-A nrPDB Length = 676 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 93/219 (42%), Gaps = 42/219 (19%) Query: 199 QTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATA---QAFLAEASVMTQLRHSNLVQLLG 253 + +G G FG V+ + G +VA+K + + + + + E +M +L H N+V Sbjct: 20 ERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVVSARE 79 Query: 254 VIVEEKGGL---------YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK------FSLDV 298 V GL + EY G L YL C LK D+ Sbjct: 80 V----PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQ-----FENCCGLKEGPIRTLLSDI 130 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKL------P 349 A+ YL N +HRDL N+++ + + K+ D G KE D G+L Sbjct: 131 SSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKEL----DQGELCTEFVGT 186 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 +++ APE L +KK++ D WSFG L +E + R P Sbjct: 187 LQYLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPFLP 225 >5IG1-A nrPDB Length = 344 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 66/259 (25%), Positives = 114/259 (44%), Gaps = 25/259 (9%) Query: 200 TIGKGEFGDV--MLGDYRGNKVAVKCIK----NDATAQAFLAEASVMTQLRHSNLVQLLG 253 IGKG F V + G AVK I + E + + L+H ++V + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRR 83 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 +E Y+V EY++ G L D + +R C+ + + A+++ N + Sbjct: 84 AFRDE-SHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQ----ILSALQHCHSKNII 138 Query: 312 HRDLAARNVLV-SEDNVA--KVSDFGLT--KEASSTQDTGKLPVKWTAPEALREKKFSTK 366 HRDL N+L+ S+D A K++DFGL E T + +PE +R + T Sbjct: 139 HRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPYDTA 198 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-GYKMDAP--DGCPPAVYDVMKNCW 423 DVW+ G++L+ I G P+ + + +++ Y +P D A +++K Sbjct: 199 VDVWACGVILY-ILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAML 257 Query: 424 HLDAATRPTFLQLREQLEH 442 + RPT ++E L+H Sbjct: 258 EPNPKRRPT---VQELLQH 273 >4ZSG-A nrPDB Length = 347 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/207 (24%), Positives = 96/207 (46%), Gaps = 22/207 (10%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKND----ATAQAFLAEASVMTQLRHSN 247 E ++++TIG G +G V R G +VA+K I N A+ L E ++ +H N Sbjct: 8 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 67 Query: 248 LVQLLGVIVE-----EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 ++ + ++ E +Y+V + M + L + S L + + F + + Sbjct: 68 IIAIKDILRPTVPYGEFKSVYVVLDLM-ESDLHQIIHSSQPLTL--EHVRYFLYQLLRGL 124 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPVKW-TAP 355 +Y+ +HRDL N+LV+E+ K+ DFG+ + ++ T + +W AP Sbjct: 125 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 356 E-ALREKKFSTKSDVWSFGILLWEIYS 381 E L +++ D+WS G + E+ + Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLA 211 >4TNB-A nrPDB Length = 590 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 86/198 (43%), Gaps = 11/198 (5%) Query: 199 QTIGKGEFGDVMLGDYRGNKVAVKC-------IKNDATAQAFLAEASVMTQLRHSNLVQL 251 + +GKG FG+V R C IK L E ++ ++ +S V Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-NSQFVVN 248 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 L E K L +V M G L ++ + G + L ++ ++ +E L N V Sbjct: 249 LAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTV 308 Query: 312 HRDLAARNVLVSEDNVAKVSDFGL-TKEASSTQDTGKL-PVKWTAPEALREKKFSTKSDV 369 +RDL N+L+ + ++SD GL K G++ V + APE L +++ D Sbjct: 309 YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDY 368 Query: 370 WSFGILLWEIYSFGRVPY 387 W G L++E+ G+ P+ Sbjct: 369 WGLGCLIYEMIE-GQSPF 385 >4IC8-A nrPDB Length = 442 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/207 (24%), Positives = 96/207 (46%), Gaps = 22/207 (10%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKND----ATAQAFLAEASVMTQLRHSN 247 E ++++TIG G +G V R G +VA+K I N A+ L E ++ +H N Sbjct: 56 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 115 Query: 248 LVQLLGVIVE-----EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 ++ + ++ E +Y+V + M + L + S L + + F + + Sbjct: 116 IIAIKDILRPTVPYGEFKSVYVVLDLM-ESDLHQIIHSSQPLTL--EHVRYFLYQLLRGL 172 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPVKW-TAP 355 +Y+ +HRDL N+LV+E+ K+ DFG+ + ++ T + +W AP Sbjct: 173 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 232 Query: 356 E-ALREKKFSTKSDVWSFGILLWEIYS 381 E L +++ D+WS G + E+ + Sbjct: 233 ELMLSLHEYTQAIDLWSVGCIFGEMLA 259 >3TAC-A nrPDB Length = 361 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 73/290 (25%), Positives = 127/290 (43%), Gaps = 31/290 (10%) Query: 172 VMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCI----- 224 V G++A D + + +L + IGKG F V + G + AVK + Sbjct: 12 VPRGSMADDDVLFEDVY-------ELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKF 64 Query: 225 --KNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG 282 + + EAS+ L+H ++V+LL + G LY+V E+M L + R Sbjct: 65 TSSPGLSTEDLKREASICHMLKHPHIVELLETYSSD-GMLYMVFEFMDGADLCFEIVKRA 123 Query: 283 RS--VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV-SEDNVA--KVSDFGLTK 337 + V + + EA+ Y NN +HRD+ VL+ S++N A K+ FG+ Sbjct: 124 DAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAI 183 Query: 338 E--ASSTQDTGKLPV-KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD 394 + S G++ + APE ++ + + DVW G++L+ + S G +P+ + Sbjct: 184 QLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLS-GCLPFYGTKERL 242 Query: 395 VVPRVEKGYKMDAP--DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 ++ YKM+ + D+++ LD A R T + E L H Sbjct: 243 FEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT---VYEALNH 289 >6E9W-A nrPDB Length = 443 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 99/212 (46%), Gaps = 18/212 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKN----DATAQAFLAEASVMTQL 243 + ++ ++++ IG+G FG+V L ++ + A+K + + AF E + Sbjct: 99 MKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAF 158 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +S V L ++ LY+V EYM G LV+ + + + ++ +V A++ Sbjct: 159 ANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD---VPEKWARFYTAEVVLALD 215 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTAPEALR 359 + F+HRD+ N+L+ + K++DFG + KE DT + +PE L+ Sbjct: 216 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 360 EKK----FSTKSDVWSFGILLWEIYSFGRVPY 387 + + + D WS G+ L+E+ G P+ Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEML-VGDTPF 306 >5JZN-A nrPDB Length = 280 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 86/191 (45%), Gaps = 12/191 (6%) Query: 196 KLLQTIGKGEFGDVMLGDYRGN--KVAVKCIKND---ATAQAFLAEASVMTQLRHSNLVQ 250 K+ +TIG G F V R + A+K IK E S++ +++H N+V Sbjct: 22 KVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVL 81 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 L+ + + LY+V E + G L D + S + + ++L A++YL N Sbjct: 82 LIEEM-DVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNL--ASAIKYLHSLNI 138 Query: 311 VHRDLAARNVLVSE----DNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTK 366 VHRD+ N+LV E K+ DFGL T + APE + E + K Sbjct: 139 VHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLK 198 Query: 367 SDVWSFGILLW 377 D+W+ G++ + Sbjct: 199 VDIWAAGVITY 209 >4MWI-A nrPDB Length = 294 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 70/283 (24%), Positives = 121/283 (42%), Gaps = 41/283 (14%) Query: 191 NMKELKLLQTIG-------KGEFGDVMLGDYRGNKVAVKCIKN------DATAQAFLAEA 237 +KE+K Q G + E + G+Y VA+K K Q F E Sbjct: 15 QIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEI 74 Query: 238 SVMTQLRHSNLVQLLGVIVEEK---GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK- 293 M + N++++ G+ ++E IV EY G+L + L LG +L Sbjct: 75 KTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVL 134 Query: 294 ------FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS----TQ 343 + L EA E +H + + N LV++ K++ F L K +S T Sbjct: 135 GAARGLYRLHHSEAPE-------LHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTT 187 Query: 344 DTGKLPVKWTA---PEALRE--KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 VK TA P+ L + ++ KS+++SFGI+LWEI + G +P+ + + Sbjct: 188 REKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIAT-GDIPFQGCNSEKIRKL 246 Query: 399 VE-KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 V K + + CP + +++ C D + RP+ ++ ++L Sbjct: 247 VAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL 289 >4NFN-A nrPDB Length = 309 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/255 (23%), Positives = 114/255 (44%), Gaps = 20/255 (7%) Query: 196 KLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLV-QLL 252 K+L+ IG G FG++ + VA+K Q E +V+ +L+ + V + + Sbjct: 24 KVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFI 83 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 G EK Y+V + + +L D RS+ R L+ + E++E + F+H Sbjct: 84 GCGRNEKFN-YVVMQLQGR-NLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLH 141 Query: 313 RDLAARNV----LVSEDNVAKVSDFGLTKEASSTQDTGKLP---------VKWTAPEALR 359 RD+ N L S + DFGL ++ ++T + P V++ + A + Sbjct: 142 RDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHK 201 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA-PDGCPPAVYDV 418 ++ D+WS +L E ++ G++P+ +I K+ V +++ Y+ P + Sbjct: 202 NREMGRHDDLWSLFYMLVE-FAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLF 260 Query: 419 MKNCWHLDAATRPTF 433 + + LD T+P + Sbjct: 261 LDHIASLDYFTKPDY 275 >2W4O-A nrPDB Length = 349 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 53/186 (28%), Positives = 85/186 (45%), Gaps = 14/186 (7%) Query: 201 IGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE 258 +G+G V +G + A+K +K + E V+ +L H N+++L I E Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKL-KEIFET 119 Query: 259 KGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLA 316 + +V E + G L D + +G D + + + EA+ YL N VHRDL Sbjct: 120 PTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQ----ILEAVAYLHENGIVHRDLK 175 Query: 317 ARNVLVSE---DNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWS 371 N+L + D K++DFGL+K E T + APE LR + + D+WS Sbjct: 176 PENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWS 235 Query: 372 FGILLW 377 GI+ + Sbjct: 236 VGIITY 241 >5E8V-A nrPDB Length = 316 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 98/221 (44%), Gaps = 39/221 (17%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNK------VAVKCIKNDATAQAFLAEASVMT--QLRHS 246 ++L +GKG F +V + N VAVK + A ++ E + + L+H Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYA-SWKTEKDIFSDINLKHE 69 Query: 247 NLVQLLGVIVEEKGGL----YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 N++Q L E K L +++T + AKG+L +YL R V+ + L K + + Sbjct: 70 NILQFL-TAEERKTELGKQYWLITAFHAKGNLQEYLT---RHVISWEDLRKLGSSLARGI 125 Query: 303 EYLEGNN---------FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP---- 349 +L ++ VHRDL + N+LV D + DFGL+ T L Sbjct: 126 AHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 185 Query: 350 ---VKWTAPEALREK------KFSTKSDVWSFGILLWEIYS 381 ++ APE L + ++DV+S ++LWE+ S Sbjct: 186 VGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTS 226 >1G3N-A nrPDB Length = 326 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 50/196 (25%), Positives = 92/196 (46%), Gaps = 17/196 (8%) Query: 201 IGKGEFGDVMLG-DYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLR---HSNLVQ 250 IG+G +G V D + G VA+K ++ + + + E +V+ L H N+V+ Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 Query: 251 LLGVIV----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 L V + + L +V E++ + L YL + + + + +++L Sbjct: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKKFS 364 + VHRDL +N+LV+ K++DFGL + S + V + APE L + ++ Sbjct: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 Query: 365 TKSDVWSFGILLWEIY 380 T D+WS G + E++ Sbjct: 198 TPVDLWSVGCIFAEMF 213 >4BTK-A nrPDB Length = 337 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 59/255 (23%), Positives = 114/255 (44%), Gaps = 20/255 (7%) Query: 196 KLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLV-QLL 252 K+L+ IG G FG++ + VA+K Q E +V+ +L+ + V + + Sbjct: 59 KVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFI 118 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 G EK Y+V + + +L D RS+ R L+ + E++E + F+H Sbjct: 119 GCGRNEKFN-YVVMQLQGR-NLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLH 176 Query: 313 RDLAARNV----LVSEDNVAKVSDFGLTKEASSTQDTGKLP---------VKWTAPEALR 359 RD+ N L S + DFGL ++ ++T + P V++ + A + Sbjct: 177 RDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHK 236 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA-PDGCPPAVYDV 418 ++ D+WS +L E ++ G++P+ +I K+ V +++ Y+ P + Sbjct: 237 NREMGRHDDLWSLFYMLVE-FAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLF 295 Query: 419 MKNCWHLDAATRPTF 433 + + LD T+P + Sbjct: 296 LDHIASLDYFTKPDY 310 >3OZ6-A nrPDB Length = 388 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 108/230 (46%), Gaps = 38/230 (16%) Query: 192 MKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCI----KNDATAQAFLAEASVMTQLR- 244 +++ +L++ +GKG +G V + G VAVK I +N AQ E ++T+L Sbjct: 8 LRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 245 HSNLVQLLGVI-VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H N+V LL V+ + +Y+V +YM + L +R+ ++L + + ++ Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYM-ETDLHAVIRA---NILEPVHKQYVVYQLIKVIK 123 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-TGKLPVK----------- 351 YL +HRD+ N+L++ + KV+DFGL++ + + T +P+ Sbjct: 124 YLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDD 183 Query: 352 ------------WTAPEALR-EKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 + APE L K++ D+WS G +L EI G+ +P Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILC-GKPIFP 232 >2V7O-A nrPDB Length = 336 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 62/257 (24%), Positives = 114/257 (44%), Gaps = 25/257 (9%) Query: 194 ELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATA----QAFLAEASVMTQLRHSN 247 + +L + +GKG F V + + A K I + Q EA + L+H N Sbjct: 32 DYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPN 91 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYL 305 +V+L I EE G Y+V + + G L + + +R C+ + + E++ ++ Sbjct: 92 IVRLHDSISEE-GFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQ----ILESVNHI 146 Query: 306 EGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEAL 358 ++ VHRDL N+L++ + K++DFGL E Q P + +PE L Sbjct: 147 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTP-GYLSPEVL 205 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAV 415 R+ + D+W+ G++L+ I G P+ + +++ G Y +P D P Sbjct: 206 RKDPYGKPVDIWACGVILY-ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEA 264 Query: 416 YDVMKNCWHLDAATRPT 432 +++ ++ A R T Sbjct: 265 KNLINQMLTINPAKRIT 281 >6DTL-A nrPDB Length = 364 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 85/195 (43%), Gaps = 16/195 (8%) Query: 198 LQTIGKGEFGDV--MLGDYRGNKVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQL 251 + IGKG +G V + VA+K I N A+ L E ++ + H N+V + Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 252 LGVIV----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +I +YI E M L +RS L + F + ++Y+ Sbjct: 95 RDIIPPPLRNAFNDVYIAYELM-DTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHS 151 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-DTGKLPVKW-TAPE-ALREKKFS 364 N +HRDL N+L++ + K+ DFGL + S + T + +W APE L ++ Sbjct: 152 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 211 Query: 365 TKSDVWSFGILLWEI 379 DVWS G + E+ Sbjct: 212 AAIDVWSVGCIFMEL 226 >4PWN-A nrPDB Length = 274 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 68/261 (26%), Positives = 114/261 (43%), Gaps = 22/261 (8%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVK-CIKND-----ATAQAFLAEASVM 240 G + + + LK IG+G F V G V V C D + Q F EA ++ Sbjct: 4 GMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEML 63 Query: 241 TQLRHSNLVQLLGV---IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 L+H N+V+ V+ K + +VTE M G+L YL+ V+ L + Sbjct: 64 KGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR--FKVMKIKVLRSWCRQ 121 Query: 298 VCEAMEYLEGNN--FVHRDLAARNVLVS-EDNVAKVSDFGLT---KEASSTQDTGKLPVK 351 + + +++L +HRDL N+ ++ K+ D GL K AS + P + Sbjct: 122 ILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTP-E 180 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP-LKDVVPRVEKGYKMDAPDG 410 + APE + E+K+ DV++FG+ + E+ + PY + RV G K + D Sbjct: 181 FMAPE-MYEEKYDESVDVYAFGMCMLEMAT-SEYPYSECQNAAQIYRRVTSGVKPASFDK 238 Query: 411 CP-PAVYDVMKNCWHLDAATR 430 P V ++++ C + R Sbjct: 239 VAIPEVKEIIEGCIRQNKDER 259 >3PG1-A nrPDB Length = 362 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 95/202 (47%), Gaps = 23/202 (11%) Query: 201 IGKGEFGDVMLG-DYRGNKVAVKCIKNDAT--------AQAFLA-----EASVMTQLRHS 246 I G +G V G D G VA+K + N + + +FL E ++ H Sbjct: 30 ISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFHHP 89 Query: 247 NLVQLLGVIV--EEKG--GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 N++ L + V EE LY+VTE M + L + + R V+ + F + + Sbjct: 90 NILGLRDIFVHFEEPAMHKLYLVTELM-RTDLAQVIHDQ-RIVISPQHIQYFMYHILLGL 147 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-TGKLPVKW-TAPE-ALR 359 L VHRDL N+L++++N + DF L +E ++ + T + +W APE ++ Sbjct: 148 HVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAPELVMQ 207 Query: 360 EKKFSTKSDVWSFGILLWEIYS 381 K F+ D+WS G ++ E+++ Sbjct: 208 FKGFTKLVDMWSAGCVMAEMFN 229 >2A1A-B nrPDB Length = 284 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 95/214 (44%), Gaps = 30/214 (14%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK-NDATAQAFLAEASVMTQLR 244 + ++ KE++L IG G FG V +R G +K +K N+ A+ E + +L Sbjct: 9 FGMDFKEIEL---IGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAER---EVKALAKLD 62 Query: 245 HSNLVQLLGV---------------IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 H N+V G + L+I E+ KG+L ++ R L Sbjct: 63 HVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKV 122 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT----KEASSTQDT 345 L+ + + ++Y+ ++RDL N+ + + K+ DFGL + T+ Sbjct: 123 LALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK 182 Query: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEI 379 G L ++ +PE + + + + D+++ G++L E+ Sbjct: 183 GTL--RYMSPEQISSQDYGKEVDLYALGLILAEL 214 >3UC3-A nrPDB Length = 361 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 68/254 (26%), Positives = 108/254 (42%), Gaps = 17/254 (6%) Query: 197 LLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQAFLAEASVMTQ-LRHSNLVQLLG 253 ++ IG G FG L + K VAVK I+ A + + + LRH N+V+ Sbjct: 24 FVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRHPNIVRFKE 83 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 VI+ L I+ EY + G L + + + GR D F + + Y HR Sbjct: 84 VILTPTH-LAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYCHSMQICHR 140 Query: 314 DLAARNVLV--SEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEALREKKFSTK-S 367 DL N L+ S K+ DFG +K + S + T P + APE L +++ K + Sbjct: 141 DLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPA-YIAPEVLLRQEYDGKIA 199 Query: 368 DVWSFGILLWEI----YSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 DVWS G+ L+ + Y F PR K + + Y + P ++ + Sbjct: 200 DVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIF 259 Query: 424 HLDAATRPTFLQLR 437 D ATR + +++ Sbjct: 260 VADPATRISIPEIK 273 >2OZA-A nrPDB Length = 356 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 12/189 (6%) Query: 199 QTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 Q +G G G V+ K A+K +++ A+ + +Q H +V+++ V Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPH--IVRIVDVYE 81 Query: 257 EEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 G L IV E + G L ++ RG + + EA++YL N HR Sbjct: 82 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 141 Query: 314 DLAARNVLVSE---DNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALREKKFSTKSD 368 D+ N+L + + + K++DFG KE +S T + APE L +K+ D Sbjct: 142 DVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCD 201 Query: 369 VWSFGILLW 377 +WS G++++ Sbjct: 202 MWSLGVIMY 210 >4MYG-A nrPDB Length = 372 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/194 (25%), Positives = 87/194 (44%), Gaps = 19/194 (9%) Query: 201 IGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEAS----VMTQLRHSNLVQLLGV 254 +G G +G V + G KVA+K + ++ F A ++ ++H N++ LL V Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 255 IVEEKG-----GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 Y+V +M D + G + + + + ++Y+ Sbjct: 111 FTPASSLRNFYDFYLVMPFMQ----TDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSAG 165 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW-TAPEA-LREKKFSTKS 367 VHRDL N+ V+ED K+ DFGL + A + + TG + +W APE L ++ Sbjct: 166 VVHRDLKPGNLAVNEDCELKILDFGLARHADA-EMTGYVVTRWYRAPEVILSWMHYNQTV 224 Query: 368 DVWSFGILLWEIYS 381 D+WS G ++ E+ + Sbjct: 225 DIWSVGCIMAEMLT 238 >2VZ6-A nrPDB Length = 313 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 63/255 (24%), Positives = 111/255 (43%), Gaps = 25/255 (9%) Query: 196 KLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATA----QAFLAEASVMTQLRHSNLV 249 +L + +GKG F V + G + A K I + Q EA + L+H N+V Sbjct: 25 QLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIV 84 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYLEG 307 +L I EE G Y++ + + G L + + +R C+ + + EA+ + Sbjct: 85 RLHDSISEE-GHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQ----ILEAVLHCHQ 139 Query: 308 NNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEALRE 360 VHRDL N+L++ + K++DFGL E Q P + +PE LR+ Sbjct: 140 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP-GYLSPEVLRK 198 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYD 417 + D+W+ G++L+ I G P+ + +++ G Y +P D P D Sbjct: 199 DPYGKPVDLWACGVILY-ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 257 Query: 418 VMKNCWHLDAATRPT 432 ++ ++ + R T Sbjct: 258 LINKMLTINPSKRIT 272 >1NY3-A nrPDB Length = 400 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 12/189 (6%) Query: 199 QTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 Q +G G G V+ K A+K +++ A+ + +Q H +V+++ V Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPH--IVRIVDVYE 125 Query: 257 EEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 G L IV E + G L ++ RG + + EA++YL N HR Sbjct: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 Query: 314 DLAARNVLVSE---DNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALREKKFSTKSD 368 D+ N+L + + + K++DFG KE +S T + APE L +K+ D Sbjct: 186 DVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCD 245 Query: 369 VWSFGILLW 377 +WS G++++ Sbjct: 246 MWSLGVIMY 254 >5U6Y-A nrPDB Length = 461 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 63/255 (24%), Positives = 111/255 (43%), Gaps = 25/255 (9%) Query: 196 KLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATA----QAFLAEASVMTQLRHSNLV 249 +L + +GKG F V + G + A K I + Q EA + L+H N+V Sbjct: 3 QLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIV 62 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYLEG 307 +L I EE G Y++ + + G L + + +R C+ + + EA+ + Sbjct: 63 RLHDSISEE-GHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQ----ILEAVLHCHQ 117 Query: 308 NNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEALRE 360 VHRDL N+L++ + K++DFGL E Q P + +PE LR+ Sbjct: 118 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP-GYLSPEVLRK 176 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYD 417 + D+W+ G++L+ I G P+ + +++ G Y +P D P D Sbjct: 177 DPYGKPVDLWACGVILY-ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 235 Query: 418 VMKNCWHLDAATRPT 432 ++ ++ + R T Sbjct: 236 LINKMLTINPSKRIT 250 >3KK8-A nrPDB Length = 284 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 95/202 (47%), Gaps = 19/202 (9%) Query: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA----QAFLAEASVMTQLRHSNLVQLL 252 + +GKG F V ++ G + A K I + Q EA + +L+H N+V+L Sbjct: 12 EELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLH 71 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 I EE Y+V + + G L + + +R C+ + + E++ Y N Sbjct: 72 DSIQEESFH-YLVFDLVTGGELFEDIVAREFYSEADASHCIQQ----ILESIAYCHSNGI 126 Query: 311 VHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLP--VKWTAPEALREKKFST 365 VHR+L N+L++ + K++DFGL E + ++ + +PE L++ +S Sbjct: 127 VHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSK 186 Query: 366 KSDVWSFGILLWEIYSFGRVPY 387 D+W+ G++L+ I G P+ Sbjct: 187 PVDIWACGVILY-ILLVGYPPF 207 >3KA0-A nrPDB Length = 320 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 48/189 (25%), Positives = 85/189 (44%), Gaps = 12/189 (6%) Query: 199 QTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 Q +G G G V+ K A+K +++ A+ + +Q H +V+++ V Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPH--IVRIVDVYE 79 Query: 257 EEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 G L IV E + G L ++ RG + + EA++YL N HR Sbjct: 80 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 139 Query: 314 DLAARNVLVSE---DNVAKVSDFGLTKEASSTQDTGK--LPVKWTAPEALREKKFSTKSD 368 D+ N+L + + + K++DFG KE +S + + APE L +K+ D Sbjct: 140 DVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPEKYDKSCD 199 Query: 369 VWSFGILLW 377 +WS G++++ Sbjct: 200 MWSLGVIMY 208 >4B6L-A nrPDB Length = 281 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 16/206 (7%) Query: 201 IGKGEFGDV--MLGDYRGNKVAVKCIKNDATA-----QAFLAEASVMTQLRHSNLVQLLG 253 +GKG F G+ AVK I A + L E + L+H ++V+ Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF-S 75 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEYLEGNNFVH 312 E+ +YI E ++ SL ++R ++L + +++ L + ++YL +H Sbjct: 76 HHFEDADNIYIFLELCSRKSLAHIWKAR-HTLLEPE--VRYYLRQILSGLKYLHQRGILH 132 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEALREKKFSTKSDV 369 RDL N ++E+ KV DFGL + K + APE L + ++DV Sbjct: 133 RDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADV 192 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDV 395 WS G +++ + G P+ LK+ Sbjct: 193 WSLGCVMYTLLC-GSPPFETADLKET 217 >3C51-A nrPDB Length = 543 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 74/319 (23%), Positives = 130/319 (40%), Gaps = 36/319 (11%) Query: 160 ADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQT-------------IGKGEF 206 DGL L++ + A EF S + L + K L+ +G+G F Sbjct: 139 GDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGF 198 Query: 207 GDVMLGDYRGNKVAVKCIKNDATA-------QAFLAEASVMTQLRHSNLVQLLGVIVEEK 259 G+V + C K + Q + E ++ ++ HS + L E K Sbjct: 199 GEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKV-HSRFIVSLAYAFETK 257 Query: 260 GGLYIVTEYMAKGSLVDYLRSRGRSVLGGD--CLLKFSLDVCEAMEYLEGNNFVHRDLAA 317 L +V M G + ++ + G + ++ + +E+L N ++RDL Sbjct: 258 TDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKP 317 Query: 318 RNVLVSEDNVAKVSDFGLTKE--ASSTQDTGKLPVK-WTAPEALREKKFSTKSDVWSFGI 374 NVL+ +D ++SD GL E A T+ G + APE L +++ D ++ G+ Sbjct: 318 ENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGV 377 Query: 375 LLWEIYSFGRVPY----PRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 L+E+ + R P+ ++ K++ RV + + PD PA D + D R Sbjct: 378 TLYEMIA-ARGPFRARGEKVENKELKQRVLE-QAVTYPDKFSPASKDFCEALLQKDPEKR 435 Query: 431 PTFLQLRE-QLEHIRTHEL 448 L R+ + +RTH L Sbjct: 436 ---LGFRDGSCDGLRTHPL 451 >2J90-A nrPDB Length = 304 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 47/205 (22%), Positives = 94/205 (45%), Gaps = 20/205 (9%) Query: 199 QTIGKGEFGDVMLGDYRGN--KVAVKCIKN--------DATAQAFLAEASVMTQLRHSNL 248 + +G G+F V +G + A K IK + + E +++ ++RH N+ Sbjct: 32 EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNI 91 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 + L I E K + ++ E ++ G L D+L + L D +F + + + YL Sbjct: 92 ITLHD-IFENKTDVVLILELVSGGELFDFLAEK--ESLTEDEATQFLKQILDGVHYLHSK 148 Query: 309 NFVHRDLAARNVLVSEDNV----AKVSDFGLTKEASSTQDTGKL--PVKWTAPEALREKK 362 H DL N+++ + NV K+ DFG+ + + + + ++ APE + + Sbjct: 149 RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEP 208 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPY 387 ++D+WS G++ + + S G P+ Sbjct: 209 LGLEADMWSIGVITYILLS-GASPF 232 >3E7O-A nrPDB Length = 360 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 86/201 (42%), Gaps = 18/201 (8%) Query: 192 MKELKLLQTIGKGEFG------DVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 245 +K + L+ IG G G D +LG K + +N A+ E ++ + H Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 246 SNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 N++ LL V +EE +Y+V E M +L + L + + + Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIHME----LDHERMSYLLYQMLC 135 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEAL 358 +++L +HRDL N++V D K+ DFGL + AS+ V + APE + Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVI 195 Query: 359 REKKFSTKSDVWSFGILLWEI 379 + D+WS G ++ E+ Sbjct: 196 LGMGYKENVDIWSVGCIMGEL 216 >4X7Q-B nrPDB Length = 312 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 93/217 (42%), Gaps = 28/217 (12%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQAFLAEASVMTQLR------- 244 E +L +GKG FG V G ++ VA+K I + SV L Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 245 -----HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 H +++LL ++G + ++ + L DY+ +G LG F V Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGP--LGEGPSRCFFGQVV 149 Query: 300 EAMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFG----LTKEASSTQDTGKL--PVKW 352 A+++ VHRD+ N+L+ AK+ DFG L E + D ++ P +W Sbjct: 150 AAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEW 209 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR 389 + R + + + VWS GILL+++ G +P+ R Sbjct: 210 IS----RHQYHALPATVWSLGILLYDMVC-GDIPFER 241 >6ED6-A nrPDB Length = 415 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/216 (24%), Positives = 99/216 (45%), Gaps = 20/216 (9%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKN----DATAQAFLAEASVM 240 G + ++ +++ IG+G FG+V L ++ ++ A+K + + AF E + Sbjct: 82 GLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI 141 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF-SLDVC 299 +S V L ++ LY+V EYM G LV+ + + + KF + +V Sbjct: 142 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVP----EKWAKFYTAEVV 197 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAP 355 A++ + +HRD+ N+L+ + K++DFG + T DT + +P Sbjct: 198 LALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISP 257 Query: 356 EALREKK----FSTKSDVWSFGILLWEIYSFGRVPY 387 E L+ + + + D WS G+ L+E+ G P+ Sbjct: 258 EVLKSQGGDGFYGRECDWWSVGVFLYEML-VGDTPF 292 >5B2L-A nrPDB Length = 324 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 69/274 (25%), Positives = 123/274 (44%), Gaps = 28/274 (10%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASVMTQ 242 + + +L+ L +G G G V +R G+ +AVK ++ N + L + V+ + Sbjct: 12 YQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLK 71 Query: 243 LRHSN-LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +VQ G + ++I E M G+ + L+ R + + L K ++ + +A Sbjct: 72 SHDCPYIVQCFGTFITNTD-VFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIVKA 128 Query: 302 MEYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTAPE 356 + YL E + +HRD+ N+L+ E K+ DFG L + T+ G + APE Sbjct: 129 LYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAG--CAAYMAPE 186 Query: 357 AL-----REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK-DVVPRV--EKGYKMDAP 408 + + + ++DVWS GI L E+ + G+ PY +V+ +V E+ + Sbjct: 187 RIDPPDPTKPDYDIRADVWSLGISLVELAT-GQFPYKNCKTDFEVLTKVLQEEPPLLPGH 245 Query: 409 DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 G +K+C D RP + +L LEH Sbjct: 246 MGFSGDFQSFVKDCLTKDHRKRPKYNKL---LEH 276 >2Y7J-A nrPDB Length = 365 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 62/257 (24%), Positives = 113/257 (43%), Gaps = 28/257 (10%) Query: 200 TIGKGEFGDVMLGDYR--GNKVAVKCIKNDA----------TAQAFLAEASVMTQLR-HS 246 IG+G V +R G++ AVK ++ A +A E ++ Q+ H Sbjct: 101 VIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHP 160 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 +++ L+ E +++V + M KG L DYL + L + EA+ +L Sbjct: 161 HIITLIDS-YESSSFMFLVFDLMRKGELFDYLTEK--VALSEKETRSIMRSLLEAVSFLH 217 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALR----- 359 NN VHRDL N+L+ ++ ++SDFG + + +L + APE L+ Sbjct: 218 ANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDE 277 Query: 360 -EKKFSTKSDVWSFGILLWEIYSFGRVPY-PRIPLKDVVPRVEKGYKMDAP--DGCPPAV 415 + + D+W+ G++L+ + + G P+ R + + +E Y+ +P D V Sbjct: 278 THPGYGKEVDLWACGVILFTLLA-GSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTV 336 Query: 416 YDVMKNCWHLDAATRPT 432 D++ +D R T Sbjct: 337 KDLISRLLQVDPEARLT 353 >2BDW-A nrPDB Length = 362 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 95/202 (47%), Gaps = 19/202 (9%) Query: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA----QAFLAEASVMTQLRHSNLVQLL 252 + +GKG F V ++ G + A K I + Q EA + +L+H N+V+L Sbjct: 35 EELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLH 94 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 I EE Y+V + + G L + + +R C+ + + E++ Y N Sbjct: 95 DSIQEESFH-YLVFDLVTGGELFEDIVAREFYSEADASHCIQQ----ILESIAYCHSNGI 149 Query: 311 VHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKKFST 365 VHR+L N+L++ + K++DFGL E + ++ + +PE L++ +S Sbjct: 150 VHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSK 209 Query: 366 KSDVWSFGILLWEIYSFGRVPY 387 D+W+ G++L+ I G P+ Sbjct: 210 PVDIWACGVILY-ILLVGYPPF 230 >4QNY-A nrPDB Length = 354 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 91/199 (45%), Gaps = 19/199 (9%) Query: 197 LLQTIGKGEFGDVMLG-DYRGNK--VAVKCIKNDATAQAFLA-----EASVMTQLRHSNL 248 L + IG G +G V+ D + + VA+K + + + LA E ++ N+ Sbjct: 24 LERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNI 83 Query: 249 VQLLGVIVEEK----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 + L ++ E YIV + M + L LRS G+ + F A+ Sbjct: 84 IGLRNILTPEDPENFDHFYIVMDIM-ETDLKQVLRS-GQELTEAHIQF-FIYQALRALHI 140 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKW-TAPE-ALRE 360 + +HRD+ N+LV+ + K+ DFGL KE + + T + ++W APE + + Sbjct: 141 IHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMED 200 Query: 361 KKFSTKSDVWSFGILLWEI 379 K +S + DVW G +L E+ Sbjct: 201 KDYSAQIDVWGIGCILGEL 219 >3LM0-A nrPDB Length = 327 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 93/208 (44%), Gaps = 19/208 (9%) Query: 182 EFYRSGWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQ----AFLA 235 E + + + L KEL G+G+F V + G + A K +K Q L Sbjct: 24 ENFNNFYILTSKEL------GRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILH 77 Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E +V+ + V L + E + ++ EY A G + ++ + +++ Sbjct: 78 EIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLI 137 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSED---NVAKVSDFGLTKE---ASSTQDTGKLP 349 + E + YL NN VH DL +N+L+S K+ DFG++++ A ++ P Sbjct: 138 KQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTP 197 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLW 377 ++ APE L +T +D+W+ GI+ + Sbjct: 198 -EYLAPEILNYDPITTATDMWNIGIIAY 224 >5J0A-A nrPDB Length = 300 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 55/243 (22%), Positives = 96/243 (39%), Gaps = 39/243 (16%) Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR---GRSVLGGD 289 + EA ++ L H N+V G L + EY + SL D + R + Sbjct: 61 LMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAA 120 Query: 290 CLLKFSLDVCEAMEYL-EGNNFVHRDLAARNVLVSED-NVAKVSDFGLTKEASSTQDT-- 345 +LK +L++ ++YL + +H D+ + NV++ D K+ D G++ + Sbjct: 121 IILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTD 180 Query: 346 ------GKLPVKWTAPEALREKKFST-KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 G P W EA+ E T K+D+++FG+ LWE+ + P I L + Sbjct: 181 PEACYIGTEP--WKPKEAVEENGVITDKADIFAFGLTLWEMMTLS---IPHINLSNDDDD 235 Query: 399 VEKGY--------------------KMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 +K + M+ D V ++ C + D RP+ + E Sbjct: 236 EDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 Query: 439 QLE 441 LE Sbjct: 296 ALE 298 >3F3Z-A nrPDB Length = 277 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 83/191 (43%), Gaps = 15/191 (7%) Query: 197 LLQTIGKGEFGDVMLGDYRGNKV--AVKCIKNDATAQA--FLAEASVMTQLRHSNLVQLL 252 L TIG+G +G+V + +G ++ A K I F E +M L H N+++L Sbjct: 13 LENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLDHPNIIRLY 72 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 E+ +Y+V E G L + R + V + DV A+ Y N H Sbjct: 73 ETF-EDNTDIYLVMELCTGGELFE--RVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAH 129 Query: 313 RDLAARNVLV---SEDNVAKVSDFGLT---KEASSTQDTGKLPVKWTAPEALREKKFSTK 366 RDL N L S D+ K+ DFGL K + P + +P+ L E + + Sbjct: 130 RDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPY-YVSPQVL-EGLYGPE 187 Query: 367 SDVWSFGILLW 377 D WS G++++ Sbjct: 188 CDEWSAGVMMY 198 >3E3P-A nrPDB Length = 360 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 95/226 (42%), Gaps = 30/226 (13%) Query: 175 GTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQA 232 AA DE R M ++ + G+G FG V LG + G VA+K + D + Sbjct: 9 NAAAAADERSRK----EMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN 64 Query: 233 FLAEASVMTQL---RHSNLVQL------LGVIVEEKGGLYIVTEYMAKG---SLVDYLRS 280 E +M L H N+VQL LG L +V EY+ +Y R Sbjct: 65 --RELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYR- 121 Query: 281 RGRSVLGGDCLLK---FSLDVCEAMEYLEGNNFVHRDLAARNVLVSE-DNVAKVSDFGLT 336 R V L+K F L +L N HRD+ NVLV+E D K+ DFG Sbjct: 122 --RQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSA 179 Query: 337 KEASSTQDTGKLPVK--WTAPEAL-REKKFSTKSDVWSFGILLWEI 379 K+ S ++ + APE + + ++T D+WS G + E+ Sbjct: 180 KKLSPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEM 225 >3SOA-A nrPDB Length = 444 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 62/258 (24%), Positives = 112/258 (43%), Gaps = 25/258 (9%) Query: 193 KELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATA----QAFLAEASVMTQLRHS 246 +E +L + +GKG F V + G + A I + Q EA + L+H Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEY 304 N+V+L I EE G Y++ + + G L + + +R C+ + + EA+ + Sbjct: 71 NIVRLHDSISEE-GHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQ----ILEAVLH 125 Query: 305 LEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEA 357 VHR+L N+L++ + K++DFGL E Q P + +PE Sbjct: 126 CHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP-GYLSPEV 184 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPA 414 LR+ + D+W+ G++L+ I G P+ + +++ G Y +P D P Sbjct: 185 LRKDPYGKPVDLWACGVILY-ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 243 Query: 415 VYDVMKNCWHLDAATRPT 432 D++ ++ + R T Sbjct: 244 AKDLINKMLTINPSKRIT 261 >1RPY-A nrPDB Length = 114 Score = 58.2 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 26/86 (30%), Positives = 50/86 (58%), Gaps = 3/86 (3%) Query: 76 KLSLMPWFHGKITREQAERLLY---PPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIM 132 +LS PWFHG ++R +A +L+ P GLF++R+S PG+ L + +GK +H R+ Sbjct: 7 ELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLS 66 Query: 133 YHASKLSIDEEVYFENLMQLVEHYTT 158 + + ++F+++ ++ H+ T Sbjct: 67 LNGHGQCHVQHLWFQSVFDMLRHFHT 92 >3UIU-A nrPDB Length = 306 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 49/227 (21%), Positives = 95/227 (41%), Gaps = 43/227 (18%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK-NDATAQAFLAEASVMTQLR 244 + ++ KE++L IG G FG V +R G ++ +K N+ A+ E + +L Sbjct: 10 FGMDFKEIEL---IGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAER---EVKALAKLD 63 Query: 245 HSNLVQLLGV----------------------------IVEEKGGLYIVTEYMAKGSLVD 276 H N+V G + L+I E+ KG+L Sbjct: 64 HVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQ 123 Query: 277 YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT 336 ++ R L L+ + + ++Y+ +HRDL N+ + + K+ DFGL Sbjct: 124 WIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLV 183 Query: 337 ----KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEI 379 + T+ G L ++ +PE + + + + D+++ G++L E+ Sbjct: 184 TSLKNDGKRTRSKGTL--RYMSPEQISSQDYGKEVDLYALGLILAEL 228 >1ZXE-A nrPDB Length = 303 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 91/222 (40%), Gaps = 39/222 (17%) Query: 198 LQTIGKGEFGDVMLG----DYRGNKVAVKCIKN-DATAQAFLAEASVMTQLRHSNLVQLL 252 + +G+G FG V+ D R A+K I++ + L+E ++ L H +V+ Sbjct: 11 IAVLGQGAFGQVVKARNALDSR--YYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVRYY 68 Query: 253 G------------VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 V++K L+I EY +L D + S + D + + E Sbjct: 69 AAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQ-QRDEYWRLFRQILE 127 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--------- 351 A+ Y+ +HR+L N+ + E K+ DFGL K + D KL + Sbjct: 128 ALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNL 187 Query: 352 --------WTAPEALR-EKKFSTKSDVWSFGILLWE-IYSFG 383 + A E L ++ K D++S GI+ +E IY F Sbjct: 188 TSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFS 229 >2XS0-A nrPDB Length = 386 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 87/205 (42%), Gaps = 18/205 (8%) Query: 192 MKELKLLQTIGKGEFG------DVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 245 +K + L+ IG G G D +L K + +N A+ E +M + H Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 246 SNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 N++ LL V +EE +YIV E M +L ++ L + + + Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMELM-DANLCQVIQME----LDHERMSYLLYQMLC 139 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEAL 358 +++L +HRDL N++V D K+ DFGL + A ++ V + APE + Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVI 199 Query: 359 REKKFSTKSDVWSFGILLWEIYSFG 383 + D+WS G ++ E+ G Sbjct: 200 LGMGYKENVDIWSVGCIMGEMIKGG 224 >2AUG-A nrPDB Length = 126 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 34/97 (35%), Positives = 53/97 (54%), Gaps = 13/97 (13%) Query: 81 PWFHGKITREQAERLLYPPE--TGLFLVRESTNYPGDYTLCVSCEGKVEHYRI------- 131 PWFH KI+R++A+RL+ G+FLVR+S + P + L +S K++H++I Sbjct: 27 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 86 Query: 132 -MYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRL 167 M+H D F +L+QLVE Y + L +L Sbjct: 87 EMFHTLD---DGHTRFTDLIQLVEFYQLNKGVLPCKL 120 >1JNK-A nrPDB Length = 423 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 86/201 (42%), Gaps = 18/201 (8%) Query: 192 MKELKLLQTIGKGEFG------DVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 245 +K + L+ IG G G D +L K + +N A+ E +M + H Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 246 SNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 N++ LL V +EE +Y+V E M +L ++ L + + + Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME----LDHERMSYLLYQMLC 175 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEAL 358 +++L +HRDL N++V D K+ DFGL + A ++ V + APE + Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 Query: 359 REKKFSTKSDVWSFGILLWEI 379 + D+WS G ++ E+ Sbjct: 236 LGMGYKENVDIWSVGCIMGEM 256 >5O2B-A nrPDB Length = 285 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 24/264 (9%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVK-CIKND-----ATAQAFLAEASVMTQLRHSNL 248 LK +G+G F V G V V C D A Q F EA ++ L+H N+ Sbjct: 18 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 77 Query: 249 VQLLGV---IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 V+ I++ K + +VTE M G+L YL+ V+ L + + + +++L Sbjct: 78 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQFL 135 Query: 306 EGNN--FVHRDLAARNVLVS-EDNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALRE 360 +HRDL N+ ++ K+ D GL S + P ++ APE + E Sbjct: 136 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTP-EFMAPE-MYE 193 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIP-LKDVVPRVEKGYKMDAPDGCP-PAVYDV 418 + + DV++FG+ + E+ + PY + +V G K + + P V ++ Sbjct: 194 EHYDESVDVYAFGMCMLEMAT-SEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEI 252 Query: 419 MKNCWHLDAATRPTFLQLREQLEH 442 ++ C + + R L +R+ L H Sbjct: 253 IEGCIRQNKSER---LSIRDLLNH 273 >5IKW-A nrPDB Length = 310 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/227 (23%), Positives = 100/227 (44%), Gaps = 31/227 (13%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC------IKNDATAQAFLAEASVMT 241 +A+ ++ L +++ +G F V L G ++C + N E ++M Sbjct: 9 FAVGRHQVTLEESLAEGGFSTVFLVRTHG---GIRCALKRMYVNNMPDLNVCKREITIMK 65 Query: 242 QLR-HSNLVQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296 +L H N+V L V + I+ EY G +V+ + + ++ +L+ Sbjct: 66 ELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFC 125 Query: 297 DVCEAMEYLE--GNNFVHRDLAARNVLVSEDNVAKVSDFG-LTKEASSTQDTGKLPVK-- 351 D CEA+ L +HRDL N+L+++ + DFG T + + Q G V+ Sbjct: 126 DTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEE 185 Query: 352 --------WTAPEALR---EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 + APE + K +TK+D+W+ G LL+++ F +P+ Sbjct: 186 IKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKL-CFFTLPF 231 >6FYV-A nrPDB Length = 337 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 90/214 (42%), Gaps = 31/214 (14%) Query: 196 KLLQTIGKGEFGDVM-LGDY--RGNKVAVKCIKNDAT-AQAFLAEASVMTQLRHSN---- 247 +++ T+G+G FG V+ D+ G VAVK +KN +A +E V+ L ++ Sbjct: 17 EIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSV 76 Query: 248 --LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 VQ+L + G + IV E + S D+++ D + + + +C+++ +L Sbjct: 77 FRCVQMLEWF-DHHGHVCIVFELLGL-STYDFIKENSFLPFQIDHIRQMAYQICQSINFL 134 Query: 306 EGNNFVHRDLAARNVL-VSEDNVA------------------KVSDFGLTKEASSTQDTG 346 N H DL N+L V D V KV DFG T Sbjct: 135 HHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTL 194 Query: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIY 380 + APE + +S DVWS G +L E Y Sbjct: 195 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY 228 >4AW2-A nrPDB Length = 437 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 48/214 (22%), Positives = 99/214 (46%), Gaps = 19/214 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR-GNKVAVKCIKND------ATAQAFLAEASVMTQ 242 L+ ++ ++L+ IG+G FG+V + + +KV I N A F E V+ Sbjct: 71 LHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN 130 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 S + L ++ LY+V +Y G L+ L S+ L + + ++ A+ Sbjct: 131 -GDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLL-SKFEDRLPEEMARFYLAEMVIAI 188 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTAPEAL 358 + + ++VHRD+ N+L+ + +++DFG L ++ + + +PE L Sbjct: 189 DSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 248 Query: 359 R-----EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 + + ++ + D WS G+ ++E+ +G P+ Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEML-YGETPF 281 >3FI2-A nrPDB Length = 353 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 86/201 (42%), Gaps = 18/201 (8%) Query: 192 MKELKLLQTIGKGEFG------DVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 245 +K + L+ IG G G D +L K + +N A+ E +M + H Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 246 SNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 N++ LL V +EE +Y+V E M +L ++ L + + + Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME----LDHERMSYLLYQMLC 137 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEAL 358 +++L +HRDL N++V D K+ DFGL + A ++ V + APE + Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 197 Query: 359 REKKFSTKSDVWSFGILLWEI 379 + D+WS G ++ E+ Sbjct: 198 LGMGYKENVDIWSVGCIMGEM 218 >3DLS-A nrPDB Length = 335 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/227 (22%), Positives = 102/227 (44%), Gaps = 35/227 (15%) Query: 173 MEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFG------------DVMLGDYRGNKVA 220 +EG A + E+ ++ + +G G FG +V++ + KV Sbjct: 12 LEGLAACEGEY--------SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVL 63 Query: 221 VKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS 280 C D E ++++++ H+N++++L I E +G +V E GS +D Sbjct: 64 EDCWIEDPKLGKVTLEIAILSRVEHANIIKVLD-IFENQGFFQLVME--KHGSGLDLFAF 120 Query: 281 RGRSVLGGDCLLKFSL-DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA 339 R + L + + A+ YL + +HRD+ N++++ED K+ DFG + Sbjct: 121 IDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFG----S 176 Query: 340 SSTQDTGKL------PVKWTAPEALREKKF-STKSDVWSFGILLWEI 379 ++ + GKL +++ APE L + + ++WS G+ L+ + Sbjct: 177 AAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTL 223 >5FG8-A nrPDB Length = 285 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 93/204 (45%), Gaps = 22/204 (10%) Query: 199 QTIGKGEFGDV--MLGDYRGNKVAVKCIKNDA-TAQAFLA---EASVMTQLRHSNLVQLL 252 + +GKG F V + G + A K I TA+ F EA + +L H N+V+L Sbjct: 20 EELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLH 79 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 I EE Y+V + + G L + + +R C+ + + E++ + N Sbjct: 80 DSIQEENYH-YLVFDLVTGGELFEDIVAREFYSEADASHCIQQ----ILESVNHCHQNGV 134 Query: 311 VHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEALREKKF 363 VHRDL N+L++ + K++DFGL E P + +PE L+++ + Sbjct: 135 VHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTP-GYLSPEVLKKEPY 193 Query: 364 STKSDVWSFGILLWEIYSFGRVPY 387 D+W+ G++L+ I G P+ Sbjct: 194 GKSVDIWACGVILY-ILLVGYPPF 216 >2KK6-A nrPDB Length = 116 Score = 56.6 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 32/82 (39%), Positives = 46/82 (56%), Gaps = 3/82 (3%) Query: 77 LSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS 136 L+ W+HG I R +A+ LL + G FLVRES PG+Y L V +G+ H+ I Y Sbjct: 14 LAEQDWYHGAIPRIEAQELL--KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQY-VD 70 Query: 137 KLSIDEEVYFENLMQLVEHYTT 158 + E F N+ QL++H+ T Sbjct: 71 NMYRFEGTGFSNIPQLIDHHYT 92 >5O2C-A nrPDB Length = 380 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 24/264 (9%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVK-CIKND-----ATAQAFLAEASVMTQLRHSNL 248 LK +G+G F V G V V C D A Q F EA ++ L+H N+ Sbjct: 27 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 86 Query: 249 VQLLGV---IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 V+ I++ K + +VTE M G+L YL+ V+ L + + + +++L Sbjct: 87 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQFL 144 Query: 306 EGNN--FVHRDLAARNVLVS-EDNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALRE 360 +HRDL N+ ++ K+ D GL S + P ++ APE + E Sbjct: 145 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTP-EFMAPE-MYE 202 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIP-LKDVVPRVEKGYKMDAPDGCP-PAVYDV 418 + + DV++FG+ + E+ + PY + +V G K + + P V ++ Sbjct: 203 EHYDESVDVYAFGMCMLEMAT-SEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEI 261 Query: 419 MKNCWHLDAATRPTFLQLREQLEH 442 ++ C + + R L +R+ L H Sbjct: 262 IEGCIRQNKSER---LSIRDLLNH 282 >3GC0-A nrPDB Length = 329 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 92/206 (44%), Gaps = 19/206 (9%) Query: 189 ALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIK----NDATAQAFLAEASVMTQ 242 A ++ + + +G+G +G+V + VA+K I+ + + E S++ + Sbjct: 30 ATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKE 89 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L+H N+++L VI L+++ EY A+ L Y+ + + F + + Sbjct: 90 LQHRNIIELKSVI-HHNHRLHLIFEY-AENDLKKYMDKNPDVSM--RVIKSFLYQLINGV 145 Query: 303 EYLEGNNFVHRDLAARNVLV-----SEDNVAKVSDFGLTKE--ASSTQDTGKLPVKWTAP 355 + +HRDL +N+L+ SE V K+ DFGL + Q T ++ W P Sbjct: 146 NFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRP 205 Query: 356 EA--LREKKFSTKSDVWSFGILLWEI 379 L + +ST D+WS + E+ Sbjct: 206 PEILLGSRHYSTSVDIWSIACIWAEM 231 >5UNP-A nrPDB Length = 369 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 92/213 (43%), Gaps = 29/213 (13%) Query: 196 KLLQTIGKGEFGDVM-LGDYR--GNKVAVKCIKN-DATAQAFLAEASVMTQLR-----HS 246 +++ T+G+G FG V+ D+R G +VA+K IKN + +A E +V+ ++ + Sbjct: 37 EIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNK 96 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 NL + + G + I E + S D+L+ + + +C+A+++L Sbjct: 97 NLCVQMFDWFDYHGHMCISFELLGL-STFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLH 155 Query: 307 GNNFVHRDLAARNVL-VSED------------------NVAKVSDFGLTKEASSTQDTGK 347 N H DL N+L V+ D +V DFG T Sbjct: 156 DNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIV 215 Query: 348 LPVKWTAPEALREKKFSTKSDVWSFGILLWEIY 380 + APE + E +S DVWS G +++E Y Sbjct: 216 STRHYRAPEVILELGWSQPCDVWSIGCIIFEYY 248 >1ZWS-A nrPDB Length = 288 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 38/158 (24%), Positives = 75/158 (47%), Gaps = 10/158 (6%) Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E S++ Q+ H N++ L V E + + ++ E ++ G L D+L + L + F Sbjct: 65 EVSILRQVLHHNVITLHDV-YENRTDVVLILELVSGGELFDFLAQK--ESLSEEEATSFI 121 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA----KVSDFGLTKEASSTQDTGKL--P 349 + + + YL H DL N+++ + N+ K+ DFGL E + + Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 ++ APE + + ++D+WS G++ + + S G P+ Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPF 218 >1GBQ-A nrPDB Length = 74 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 25/56 (44%), Positives = 38/56 (67%), Gaps = 1/56 (1%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 E IAKY+F TA+ +L F +GD+L ++ D NWYKA+ G++G IP NY++ + Sbjct: 11 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYIEMK 65 >2A27-A nrPDB Length = 321 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 38/158 (24%), Positives = 75/158 (47%), Gaps = 10/158 (6%) Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E S++ Q+ H N++ L V E + + ++ E ++ G L D+L + L + F Sbjct: 65 EVSILRQVLHHNVITLHDV-YENRTDVVLILELVSGGELFDFLAQK--ESLSEEEATSFI 121 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV----AKVSDFGLTKEASSTQDTGKL--P 349 + + + YL H DL N+++ + N+ K+ DFGL E + + Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 ++ APE + + ++D+WS G++ + + S G P+ Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPF 218 >2YAB-A nrPDB Length = 361 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 38/158 (24%), Positives = 75/158 (47%), Gaps = 10/158 (6%) Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E S++ Q+ H N++ L V E + + ++ E ++ G L D+L + L + F Sbjct: 65 EVSILRQVLHPNIITLHDV-YENRTDVVLILELVSGGELFDFLAQK--ESLSEEEATSFI 121 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV----AKVSDFGLTKEASSTQDTGKL--P 349 + + + YL H DL N+++ + N+ K+ DFGL E + + Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 ++ APE + + ++D+WS G++ + + S G P+ Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPF 218 >2HDV-A nrPDB Length = 111 Score = 55.5 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 27/83 (32%), Positives = 50/83 (60%), Gaps = 3/83 (3%) Query: 77 LSLMPWFHGKITREQAERLLYPPETG---LFLVRESTNYPGDYTLCVSCEGKVEHYRIMY 133 LS PWFHG ++R +A +L+ TG +FLVR+S G+ L + +GK +H R+ Sbjct: 6 LSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHLRLSL 65 Query: 134 HASKLSIDEEVYFENLMQLVEHY 156 +A+ + ++F+++ ++EH+ Sbjct: 66 NAAGQCRVQHLHFQSIFDMLEHF 88 >4L68-A nrPDB Length = 340 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 17/177 (9%) Query: 216 GNKVAVKCIKNDATAQ-AFLAEASVMTQLRHSNLVQLLG--VIVEEKGGLYIVTEYMAKG 272 G+ +AVK + + F E + + +LRHSNL LLG V+ EEK ++V +YM+ G Sbjct: 64 GSALAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEK---FLVYKYMSNG 120 Query: 273 SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN---NFVHRDLAARNVLVSEDNVAK 329 +L L S R L + L + +L +H+++ + +L+ ED A+ Sbjct: 121 TLHSLLDSN-RGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDAR 179 Query: 330 VSDFGLTK------EASSTQDTGKL-PVKWTAPEALREKKFSTKSDVWSFGILLWEI 379 + D GL + S+ TG L + APE S K DV+ G++L E+ Sbjct: 180 IIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLEL 236 >5U06-A nrPDB Length = 120 Score = 55.5 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 32/82 (39%), Positives = 49/82 (59%), Gaps = 7/82 (8%) Query: 82 WFHGKITREQAERLLYPPE--TGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASK-- 137 WFHG+I+RE+++RL+ GLFLVRES P + L + KV+HY I+ + Sbjct: 19 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 78 Query: 138 --LSIDE-EVYFENLMQLVEHY 156 S+D+ + F +L+QLVE + Sbjct: 79 LYFSMDDGQTRFTDLLQLVEFH 100 >1TKI-A nrPDB Length = 321 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 45/192 (23%), Positives = 89/192 (46%), Gaps = 9/192 (4%) Query: 197 LLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQAFLA-EASVMTQLRHSNLVQLLG 253 + + +G+GEFG V +K K +K T Q + E S++ RH N++ L Sbjct: 9 IAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHLHE 68 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 E L ++ E+++ + + + + L ++ + VCEA+++L +N H Sbjct: 69 SF-ESMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHSHNIGHF 126 Query: 314 DLAARNVL--VSEDNVAKVSDFGLTKEASSTQDTGKLPV--KWTAPEALREKKFSTKSDV 369 D+ N++ + K+ +FG ++ + L ++ APE + ST +D+ Sbjct: 127 DIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDM 186 Query: 370 WSFGILLWEIYS 381 WS G L++ + S Sbjct: 187 WSLGTLVYVLLS 198 >3KN6-A nrPDB Length = 325 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 38/150 (25%), Positives = 73/150 (48%), Gaps = 12/150 (8%) Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAME 303 H N+V+L V ++ ++V E + G L + ++ + S +++ + A+ Sbjct: 65 HPNIVKLHEVF-HDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMR---KLVSAVS 120 Query: 304 YLEGNNFVHRDLAARNVLVSEDN---VAKVSDFGLTKEASSTQDTGKLP---VKWTAPEA 357 ++ VHRDL N+L +++N K+ DFG + K P + + APE Sbjct: 121 HMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPEL 180 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 L + + D+WS G++L+ + S G+VP+ Sbjct: 181 LNQNGYDESCDLWSLGVILYTMLS-GQVPF 209 >5AWM-A nrPDB Length = 394 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 51/199 (25%), Positives = 85/199 (42%), Gaps = 18/199 (9%) Query: 198 LQTIGKGEFGDVMLG--DYRGNKVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQL 251 L+ IG G G V VA+K + +N A+ E +M + H N++ L Sbjct: 49 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGL 108 Query: 252 LGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 L +EE +Y+V E M +L ++ L D + + +++L Sbjct: 109 LNAFTPQRNLEEFQDVYLVMELM-DANLCQVIQMD----LDHDRMSYLLYQMLCGIKHLH 163 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKKFS 364 +HRDL N++V D K+ DFGL + A +T V + APE + ++ Sbjct: 164 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 223 Query: 365 TKSDVWSFGILLWEIYSFG 383 D+WS G ++ E+ G Sbjct: 224 ENVDIWSVGCIMGEMIRGG 242 >3GUB-A nrPDB Length = 295 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 76/158 (48%), Gaps = 10/158 (6%) Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E S++ +++H N++ L V E K + ++ E +A G L D+L + L + +F Sbjct: 64 EVSILKEIQHPNVITLHEV-YENKTDVILIGELVAGGELFDFLAEK--ESLTEEEATEFL 120 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAK----VSDFGLTKEASSTQDTGKL--P 349 + + YL H DL N+++ + NV K + DFGL + + + Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 ++ APE + + ++D+WS G++ + + S G P+ Sbjct: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPF 217 >4XZ1-A nrPDB Length = 262 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 40/98 (40%), Positives = 48/98 (48%), Gaps = 4/98 (4%) Query: 69 EGVKAGTKLSLMPWFHGKITREQAERLLY--PPETGLFLVRESTNYPGDYTLCVSCEGKV 126 E + A T MPW+H +TRE+AER LY G FL+R G Y L + V Sbjct: 153 EKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTV 211 Query: 127 EHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGL 163 HY I A K I E F+ L QLVE+ ADGL Sbjct: 212 YHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGL 249 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 3/94 (3%) Query: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS- 136 +P+F+G I+R +AE L GLFL+R+ G Y L + + + H+ I + Sbjct: 11 LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 70 Query: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 +I +L E Y+ D DGL L KP Sbjct: 71 TYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP 104 >4IAN-A nrPDB Length = 358 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 97/199 (48%), Gaps = 14/199 (7%) Query: 202 GKGEFGDVMLG--DYRGNK-VAVKCIKNDATAQAF-LAEASVMTQLRHSNLVQLLGVI-- 255 G+G F +V+ + R N+ VAVK I+N+ Q L E + +L ++ + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRL 98 Query: 256 ---VEEKGGLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGNNFV 311 K L +V E ++ +L + L+ G+ V L + +S + A++ L+ N + Sbjct: 99 FRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNIL 157 Query: 312 HRDLAARNVLVSED-NVAKVSDFGLTKEASSTQDTGKLPVK-WTAPEALREKKFSTKSDV 369 H D+ N+LV+E + K+ DFG + T L + + APE + K + D+ Sbjct: 158 HADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDM 217 Query: 370 WSFGILLWEIYSFGRVPYP 388 WS G L+E+Y+ G++ +P Sbjct: 218 WSVGCTLYELYT-GKILFP 235 >1PHK-A nrPDB Length = 298 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 77/166 (46%), Gaps = 13/166 (7%) Query: 231 QAFLAEASVMTQLR-HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 +A L E ++ ++ H N++QL E ++V + M KG L DYL + L Sbjct: 68 EATLKEVDILRKVSGHPNIIQLKDT-YETNTFFFLVFDLMKKGELFDYLTEK--VTLSEK 124 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL- 348 K + E + L N VHRDL N+L+ +D K++DFG + + + ++ Sbjct: 125 ETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVC 184 Query: 349 -PVKWTAPEALR------EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 + APE + + + D+WS G++++ + + G P+ Sbjct: 185 GTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLA-GSPPF 229 >4JLC-A nrPDB Length = 657 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 65/245 (26%), Positives = 108/245 (44%), Gaps = 30/245 (12%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ AVK N + + + E V+ +L H N+V+L Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 71 Query: 252 LGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGN 308 I EE + ++ E+ GSL L + L L DV M +L N Sbjct: 72 FA-IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 130 Query: 309 NFVHRDLAARNVL--VSED--NVAKVSDFGLTKEASSTQDTGKL--PVKWTAPE-----A 357 VHRD+ N++ + ED +V K++DFG +E + L ++ P+ Sbjct: 131 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 190 Query: 358 LR---EKKFSTKSDVWSFGILLWEIYSFGRVPY-----PRIPLKDVVPRVEKGYKMDAPD 409 LR +KK+ D+WS G+ + + G +P+ PR K+V+ ++ G A Sbjct: 191 LRKDHQKKYGATVDLWSVGVTFYHAAT-GSLPFRPFEGPRRN-KEVMYKIITGKPSGAIS 248 Query: 410 GCPPA 414 G A Sbjct: 249 GVQKA 253 >5TE0-A nrPDB Length = 347 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/220 (23%), Positives = 97/220 (44%), Gaps = 25/220 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVML-GDYRGNKVAVK--CIKNDATAQAFLAEASVMTQLR 244 + + +++ + + + +G F V L G K A+K + N+ Q E +M L Sbjct: 14 FGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLS 73 Query: 245 -HSNLVQLLGVIVEEKGG-----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 H N+V + + + I+ ++ G +V+ + R ++ + +L+ D Sbjct: 74 GHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDT 133 Query: 299 CEAMEYLE--GNNFVHRDLAARNVLVSEDNVAKVSDFG-LTKEASSTQDTGKLPVK---- 351 CEA+ L +HRDL N+L+ + + DFG T + + Q G V+ Sbjct: 134 CEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIK 193 Query: 352 ------WTAPEALR---EKKFSTKSDVWSFGILLWEIYSF 382 + APE + K +TK+D+W+ G LL+++ F Sbjct: 194 KYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYF 233 >5AP3-A nrPDB Length = 313 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 84/175 (48%), Gaps = 27/175 (15%) Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE-----ASSTQDTGKLPVK 351 ++ EA+ + + VH DL N L+ D + K+ DFG+ + S +D+ V Sbjct: 135 NMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVN 193 Query: 352 WTAPEALREKKFSTKS-----------DVWSFGILLWEIYSFGRVPYPRI--PLKDVVPR 398 + PEA+++ S ++ DVWS G +L+ + ++G+ P+ +I + + Sbjct: 194 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAI 252 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH----IRTHELH 449 ++ ++++ PD + DV+K C D R + + E L H I+TH ++ Sbjct: 253 IDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQR---ISIPELLAHPYVQIQTHPVN 304 >5ZTN-A nrPDB Length = 429 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 49/208 (23%), Positives = 95/208 (45%), Gaps = 13/208 (6%) Query: 196 KLLQTIGKGEFGDVMLG-DYRGNK-VAVKCIKNDATAQAFLAEA-SVMTQLRHSNLVQLL 252 ++L+ IGKG FG V+ D++ ++ VA+K ++N+ AE ++ LR + + Sbjct: 100 EVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTM 159 Query: 253 GVIVEEKGGLY----IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 VI + + +T + +L + ++ + KF+ + + ++ L N Sbjct: 160 NVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKN 219 Query: 309 NFVHRDLAARNVLVSEDNVA--KVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTK 366 +H DL N+L+ + + KV DFG + T + APE + ++ Sbjct: 220 RIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMP 279 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKD 394 D+WS G +L E+ + YP +P +D Sbjct: 280 IDMWSLGCILAELLT----GYPLLPGED 303 >6O8B-A nrPDB Length = 665 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 97/213 (45%), Gaps = 24/213 (11%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 78 Query: 252 LGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGN 308 I EE + ++ E+ GSL L + L L DV M +L N Sbjct: 79 FA-IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 137 Query: 309 NFVHRDLAARNVL--VSED--NVAKVSDFGLTKEASSTQDTGKL--PVKWTAPE-----A 357 VHR++ N++ + ED +V K++DFG +E + +L ++ P+ Sbjct: 138 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAV 197 Query: 358 LR---EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 LR +KK+ D+WS G+ + + G +P+ Sbjct: 198 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 229 >2LQW-A nrPDB Length = 303 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 27/75 (36%), Positives = 43/75 (57%) Query: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSID 141 W+ G ++R++A+ L G+FLVR+S+ PGDY L VS +V HY I ++ Sbjct: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73 Query: 142 EEVYFENLMQLVEHY 156 + F++L L+E Y Sbjct: 74 GDQEFDHLPALLEFY 88 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 23/50 (46%), Positives = 34/50 (68%), Gaps = 1/50 (2%) Query: 18 YNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQK 67 Y+F G +DLPF KG++L I+ ++ W+ A+NK GR G+IP YV+K Sbjct: 132 YDFPGNDAEDLPFKKGEILVIIEKPEE-QWWSARNKDGRVGMIPVPYVEK 180 >2ZMD-A nrPDB Length = 390 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 84/175 (48%), Gaps = 27/175 (15%) Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE-----ASSTQDTGKLPVK 351 ++ EA+ + + VH DL N L+ D + K+ DFG+ + S +D+ V Sbjct: 163 NMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVN 221 Query: 352 WTAPEALREKKFSTKS-----------DVWSFGILLWEIYSFGRVPYPRI--PLKDVVPR 398 + PEA+++ S ++ DVWS G +L+ + ++G+ P+ +I + + Sbjct: 222 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAI 280 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH----IRTHELH 449 ++ ++++ PD + DV+K C D R + + E L H I+TH ++ Sbjct: 281 IDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQR---ISIPELLAHPYVQIQTHPVN 332 >5UUU-A nrPDB Length = 547 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 52/254 (20%), Positives = 104/254 (40%), Gaps = 16/254 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKND----ATAQAFLAEASVMTQL 243 L M + + + IG+G FG+V G A+KC+ + +M L Sbjct: 195 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 254 Query: 244 RHSN---LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + + + L + + M G L +L G V + ++ ++ Sbjct: 255 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIIL 312 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-WTAPEALR 359 +E++ V+RDL N+L+ E ++SD GL + S + + + APE L+ Sbjct: 313 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 372 Query: 360 EK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV--VPRVEKGYKMDAPDGCPPAVY 416 + + + +D +S G +L+++ G P+ + KD + R+ ++ PD P + Sbjct: 373 KGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 431 Query: 417 DVMKNCWHLDAATR 430 +++ D R Sbjct: 432 SLLEGLLQRDVNRR 445 >3TKU-A nrPDB Length = 433 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/214 (21%), Positives = 97/214 (45%), Gaps = 19/214 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKN-----DATAQAFLAEASVMTQ 242 L+ ++ ++++ IG+G FG+V + + + A+K + A F E V+ Sbjct: 87 LHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVN 146 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + L +++ LY+V +Y G L+ L S+ L D + ++ A+ Sbjct: 147 -GDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLL-SKFEDKLPEDMARFYIGEMVLAI 204 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTAPEAL 358 + + ++VHRD+ NVL+ + +++DFG + + + + +PE L Sbjct: 205 DSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEIL 264 Query: 359 REK-----KFSTKSDVWSFGILLWEIYSFGRVPY 387 + K+ + D WS G+ ++E+ +G P+ Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEML-YGETPF 297 >3HKO-A nrPDB Length = 345 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 67/280 (23%), Positives = 108/280 (38%), Gaps = 63/280 (22%) Query: 180 QDEFYRSGWALNM-KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK----------NDA 228 ++ +++ G L + K+ L IG+G +G V + A++ IK N Sbjct: 12 ENLYFQGGSLLELQKKYHLKGAIGQGSYGVVRVA-IENQTRAIRAIKIMNKNKIRQINPK 70 Query: 229 TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-----SRGR 283 + E +M +L H N+ +L V E++ + +V E G L+D L S G+ Sbjct: 71 DVERIKTEVRLMKKLHHPNIARLYEV-YEDEQYICLVMELCHGGHLLDKLNVFIDDSTGK 129 Query: 284 SVL-------------------GGDCLLKFSLD--------------VCEAMEYLEGNNF 310 + G + SLD + A+ YL Sbjct: 130 CAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGI 189 Query: 311 VHRDLAARNVLVSEDNV--AKVSDFGLTKEASSTQD-------TGKLPVKWTAPEALR-- 359 HRD+ N L S + K+ DFGL+KE + T + APE L Sbjct: 190 CHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTT 249 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 + + K D WS G+LL + G VP+P + D + +V Sbjct: 250 NESYGPKCDAWSAGVLL-HLLLMGAVPFPGVNDADTISQV 288 >6NT9-A nrPDB Length = 742 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 96/213 (45%), Gaps = 24/213 (11%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 Query: 252 LGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGN 308 I EE + ++ E+ GSL L + L L DV M +L N Sbjct: 71 FA-IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 Query: 309 NFVHRDLAARNVL--VSED--NVAKVSDFGLTKEASSTQDTGKL--PVKWTAPE-----A 357 VHR++ N++ + ED +V K++DFG +E + L ++ P+ Sbjct: 130 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 Query: 358 LR---EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 LR +KK+ D+WS G+ + + G +P+ Sbjct: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 >4EUT-A nrPDB Length = 396 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 96/213 (45%), Gaps = 24/213 (11%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 252 LGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGN 308 I EE + ++ E+ GSL L + L L DV M +L N Sbjct: 73 FA-IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 131 Query: 309 NFVHRDLAARNVL--VSED--NVAKVSDFGLTKEASSTQDTGKL--PVKWTAPE-----A 357 VHR++ N++ + ED +V K++DFG +E + L ++ P+ Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 358 LR---EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 LR +KK+ D+WS G+ + + G +P+ Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 223 >3HMP-A nrPDB Length = 342 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 84/175 (48%), Gaps = 27/175 (15%) Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE-----ASSTQDTGKLPVK 351 ++ EA+ + + VH DL N L+ D + K+ DFG+ + S +D+ V Sbjct: 163 NMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVN 221 Query: 352 WTAPEALREKKFSTKS-----------DVWSFGILLWEIYSFGRVPYPRI--PLKDVVPR 398 + PEA+++ S ++ DVWS G +L+ + ++G+ P+ +I + + Sbjct: 222 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAI 280 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH----IRTHELH 449 ++ ++++ PD + DV+K C D R + + E L H I+TH ++ Sbjct: 281 IDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQR---ISIPELLAHPYVQIQTHPVN 332 >6CMQ-A nrPDB Length = 427 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 68/158 (43%), Gaps = 34/158 (21%) Query: 82 WFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSC----------EGKVEHYR 130 WFHG ++ ++AE+LL + G FLVRES ++PGD+ L V + KV H Sbjct: 10 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 69 Query: 131 IMYHASKLSIDEEVYFENLMQLVEHYT----TDADGLCTRLIKP---------------- 170 I K + F++L LVEHY + G +L +P Sbjct: 70 IRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVR 129 Query: 171 ---KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGE 205 K+ E T + F+ L +E KLL + +G+ Sbjct: 130 ELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQ 167 >4H1O-A nrPDB Length = 560 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 68/158 (43%), Gaps = 34/158 (21%) Query: 82 WFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSC----------EGKVEHYR 130 WFHG ++ ++AE+LL + G FLVRES ++PGD+ L V + KV H Sbjct: 133 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 192 Query: 131 IMYHASKLSIDEEVYFENLMQLVEHYT----TDADGLCTRLIKP---------------- 170 I K + F++L LVEHY + G +L +P Sbjct: 193 IRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVR 252 Query: 171 ---KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGE 205 K+ E T + F+ L +E KLL + +G+ Sbjct: 253 ELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQ 290 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/76 (38%), Positives = 37/76 (48%), Gaps = 1/76 (1%) Query: 82 WFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSI 140 WFH IT +AE LL G FL R S + PGD+TL V G V H +I + Sbjct: 27 WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGGYYDL 86 Query: 141 DEEVYFENLMQLVEHY 156 F L +LV++Y Sbjct: 87 YGGEKFATLAELVQYY 102 >4C59-A nrPDB Length = 340 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/247 (22%), Positives = 99/247 (40%), Gaps = 35/247 (14%) Query: 175 GTVAAQDEFYRSGWALNMKELKLL--QTIGKGEFGDVM----LGDYRGNKVAVKCIKNDA 228 G + +D+ G + + EL+L + + +G F V +G R + + Sbjct: 7 GGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEE 66 Query: 229 TAQAFLAEASVMTQLR-HSNLVQLLGV--IVEEKGGL----YIVTEYMAKGSLVDYLRS- 280 +A + E M +L H N+VQ I +E+ +++ + KG LV++L+ Sbjct: 67 KNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKM 126 Query: 281 RGRSVLGGDCLLKFSLDVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 R L D +LK C A++++ +HRDL N+L+S K+ DFG Sbjct: 127 ESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATT 186 Query: 339 ASSTQD---------------TGKLPVKWTAPEAL---REKKFSTKSDVWSFGILLWEIY 380 S D T + PE + K D+W+ G +L+ + Sbjct: 187 ISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILY-LL 245 Query: 381 SFGRVPY 387 F + P+ Sbjct: 246 CFRQHPF 252 >6GVJ-A nrPDB Length = 429 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 84/175 (48%), Gaps = 27/175 (15%) Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE-----ASSTQDTGKLPVK 351 ++ EA+ + + VH DL N L+ D + K+ DFG+ + S +D+ V Sbjct: 251 NMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVN 309 Query: 352 WTAPEALREKKFSTKS-----------DVWSFGILLWEIYSFGRVPYPRI--PLKDVVPR 398 + PEA+++ S ++ DVWS G +L+ + ++G+ P+ +I + + Sbjct: 310 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAI 368 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH----IRTHELH 449 ++ ++++ PD + DV+K C D R + + E L H I+TH ++ Sbjct: 369 IDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQR---ISIPELLAHPYVQIQTHPVN 420 >3PVW-A nrPDB Length = 695 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 52/254 (20%), Positives = 104/254 (40%), Gaps = 16/254 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKND----ATAQAFLAEASVMTQL 243 L M + + + IG+G FG+V G A+KC+ + +M L Sbjct: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 Query: 244 RHSN---LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + + + L + + M G L +L G V + ++ ++ Sbjct: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIIL 303 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-WTAPEALR 359 +E++ V+RDL N+L+ E ++SD GL + S + + + APE L+ Sbjct: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 Query: 360 EK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV--VPRVEKGYKMDAPDGCPPAVY 416 + + + +D +S G +L+++ G P+ + KD + R+ ++ PD P + Sbjct: 364 KGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 Query: 417 DVMKNCWHLDAATR 430 +++ D R Sbjct: 423 SLLEGLLQRDVNRR 436 >5Y86-A nrPDB Length = 588 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%) Query: 196 KLLQTIGKGEFGDVM-LGDYRGNK-VAVKCIKNDATAQAFLAEA-SVMTQLRHSNLVQLL 252 ++L+ IGKG FG V + D++ + VA+K ++N+ AE ++ L+ + + Sbjct: 210 EVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSM 269 Query: 253 GVI-----VEEKGGLYIVTEYMAKG--SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 VI + + + E ++ L+ + +G SV + KF+ + ++++ L Sbjct: 270 NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV---QLVRKFAQSILQSLDAL 326 Query: 306 EGNNFVHRDLAARNVLVSED--NVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 N +H DL N+L+ + KV DFG + T + APE + ++ Sbjct: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRY 386 Query: 364 STKSDVWSFGILLWEIYS 381 ST D+WSFG +L E+ + Sbjct: 387 STPIDIWSFGCILAELLT 404 >1MIL-A nrPDB Length = 104 Score = 52.4 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 27/55 (49%), Positives = 34/55 (61%), Gaps = 2/55 (3%) Query: 74 GTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEH 128 G++L PWFHGK++R +AE LL G FLVREST PG Y L G+ +H Sbjct: 1 GSQLRGEPWFHGKLSRREAEALL--QLNGDFLVRESTTTPGQYVLTGLQSGQPKH 53 >3QWY-A nrPDB Length = 308 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 22/53 (41%), Positives = 35/53 (66%), Gaps = 1/53 (1%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 + + F G E DLPF +G+ L I++ T +W++A+N +G G++PANYVQ Sbjct: 150 VVGTFKFTGERETDLPFEQGERLEILSKTNQ-DWWEARNALGTTGLVPANYVQ 201 >3RP9-A nrPDB Length = 458 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 96/224 (42%), Gaps = 46/224 (20%) Query: 201 IGKGEFGDVMLGDYRGNK--VAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 IG G +G V + K VA+K I ++ + L E +++ +L H ++V++L + Sbjct: 61 IGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDI 120 Query: 255 I----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEYLEGNN 309 + VE+ LY+V E +A R+ V + +K L ++ ++Y+ Sbjct: 121 VIPKDVEKFDELYVVLE-IADSDFKKLFRT---PVYLTELHIKTLLYNLLVGVKYVHSAG 176 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKEAS----------------------------- 340 +HRDL N LV++D KV DFGL + Sbjct: 177 ILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNL 236 Query: 341 STQDTGKLPVKW-TAPE-ALREKKFSTKSDVWSFGILLWEIYSF 382 Q TG + +W APE L ++ ++ DVWS G + E+ + Sbjct: 237 KRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNM 280 >3NIE-A nrPDB Length = 429 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 55/235 (23%), Positives = 101/235 (42%), Gaps = 46/235 (19%) Query: 201 IGKGEFGDVMLG-DYRGNK-VAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 IG+G +G V L D NK VA+K + ++ + L E +++ +L+ +++L + Sbjct: 36 IGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLHDL 95 Query: 255 IVEEK----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 I+ E LYIV E +A L ++ L + ++ +++ + Sbjct: 96 IIPEDLLKFDELYIVLE-IADSDLKKLFKTP--IFLTEQHVKTILYNLLLGEKFIHESGI 152 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-------------------------- 344 +HRDL N L+++D K+ DFGL + +S +D Sbjct: 153 IHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQ 212 Query: 345 -TGKLPVKW-TAPE-ALREKKFSTKSDVWSFGILLWEIYSFGRV----PYPRIPL 392 T + +W APE L ++ ++ D+WS G + E+ + + P R PL Sbjct: 213 LTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPL 267 >4EUU-A nrPDB Length = 319 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 96/213 (45%), Gaps = 24/213 (11%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 252 LGVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGN 308 I EE + ++ E+ GSL L + L L DV M +L N Sbjct: 73 FA-IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 131 Query: 309 NFVHRDLAARNVL--VSED--NVAKVSDFGLTKEASSTQDTGKL--PVKWTAPE-----A 357 VHR++ N++ + ED +V K++DFG +E + L ++ P+ Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 358 LR---EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 LR +KK+ D+WS G+ + + G +P+ Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 223 >2WO6-A nrPDB Length = 382 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 26/229 (11%) Query: 201 IGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQAFLAEASVMTQL-----RHSNLVQLLG 253 IGKG FG V+ R + VA+K IKN +AFL +A + +L +H ++ Sbjct: 62 IGKGSFGQVVKAYDRVEQEWVAIKIIKN---KKAFLNQAQIEVRLLELMNKHDTEMKYYI 118 Query: 254 VIVEE----KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN- 308 V ++ + L +V E M +L D LR+ + + KF+ +C A+ +L Sbjct: 119 VHLKRHFMFRNHLCLVFE-MLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPE 177 Query: 309 -NFVHRDLAARNVLV--SEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFST 365 + +H DL N+L+ + + K+ DFG + + + +PE L + Sbjct: 178 LSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDL 237 Query: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414 D+WS G +L E+++ G PL V++ K+ G PPA Sbjct: 238 AIDMWSLGCILVEMHT-GE------PLFSGANEVDQMNKIVEVLGIPPA 279 >2EYZ-A nrPDB Length = 304 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 23/50 (46%), Positives = 33/50 (66%) Query: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRI 131 W+ G+++R++A LL G+FLVR+S+ PGDY L VS +V HY I Sbjct: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYII 62 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 22/52 (42%), Positives = 35/52 (67%), Gaps = 1/52 (1%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQK 67 A ++F+G E+DLPF KGD+L I ++ W+ A++ G+ G+IP YV+K Sbjct: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEE-QWWNAEDSEGKRGMIPVPYVEK 189 >5Z33-A nrPDB Length = 425 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 90/199 (45%), Gaps = 21/199 (10%) Query: 199 QTIGKGEFGDV--MLGDYRGNKVAVKCIKN----DATAQAFLAEASVMTQLR-HSNLVQL 251 + +G+G +G V + + VA+K + N A+ L E ++ R H N+ L Sbjct: 37 KELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCL 96 Query: 252 LGVIVEEKGGL---YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 + + Y+ E M + L +RS G+ + F + ++Y+ Sbjct: 97 YDMDIPRPDNFNETYLYEELM-ECDLAAIIRS-GQPLTDAH-FQSFIYQILCGLKYIHSA 153 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKW-TAPEALREK 361 N +HRDL N+LV+ D K+ DFGL + E ++ T + +W APE + Sbjct: 154 NVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIMLSF 213 Query: 362 KFSTKS-DVWSFGILLWEI 379 + TK+ DVWS G +L E+ Sbjct: 214 QSYTKAIDVWSVGCILAEL 232 >2EKX-A nrPDB Length = 110 Score = 51.2 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 34/109 (31%), Positives = 59/109 (54%), Gaps = 9/109 (8%) Query: 70 GVKAGTKLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSC------ 122 G + L WF G I+R Q+E+LL + G F+VR S+ G YT+ + Sbjct: 1 GSSGSSGLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDK 59 Query: 123 EGKVEHYRIMYHA-SKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 +G V+HY + +A +KL + E F+++ +L+ ++ ++ G+ TRL P Sbjct: 60 KGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHP 108 >3RAW-A nrPDB Length = 381 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 48/213 (22%), Positives = 88/213 (41%), Gaps = 29/213 (13%) Query: 196 KLLQTIGKGEFGDVM--LGDYRG-NKVAVKCIKNDAT-AQAFLAEASVMTQLRHSN---- 247 +++ +G+G FG V+ L RG ++VA+K I+N +A E +V+ +++ + Sbjct: 54 EIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENK 113 Query: 248 -LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 L L+ G + I E + K + ++L+ + + +C A+ +L Sbjct: 114 FLCVLMSDWFNFHGHMCIAFELLGKNTF-EFLKENNFQPYPLPHVRHMAYQLCHALRFLH 172 Query: 307 GNNFVHRDLAARNVLVS-------------------EDNVAKVSDFGLTKEASSTQDTGK 347 N H DL N+L ++ +V+DFG T Sbjct: 173 ENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIV 232 Query: 348 LPVKWTAPEALREKKFSTKSDVWSFGILLWEIY 380 + PE + E ++ DVWS G +L+E Y Sbjct: 233 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYY 265 >3N9X-A nrPDB Length = 432 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/233 (24%), Positives = 101/233 (43%), Gaps = 45/233 (19%) Query: 201 IGKGEFGDVMLGDYRGN---KVAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQLLG 253 IG+G +G V L Y N VA+K + ++ + L E +++ +L+ +++L Sbjct: 34 IGRGSYGYVYLA-YDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYD 92 Query: 254 VIVEEK----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 +I+ + LYIV E +A L ++ L + + ++ ++ + Sbjct: 93 LIIPDDLLKFDELYIVLE-IADSDLKKLFKTP--IFLTEEHIKTILYNLLLGENFIHESG 149 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----------------------- 346 +HRDL N L+++D KV DFGL + +S +DT Sbjct: 150 IIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLT 209 Query: 347 -KLPVKW-TAPEALREKKFSTKS-DVWSFGILLWEIYSFGRV----PYPRIPL 392 + +W APE + ++ TKS D+WS G + E+ + + P R PL Sbjct: 210 SHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPL 262 >6EAS-A nrPDB Length = 308 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/221 (24%), Positives = 95/221 (42%), Gaps = 29/221 (13%) Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYI-VTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 ++++ H N + LLG EE + V EY G+L ++L R L L+ S+ + Sbjct: 95 LSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGI 154 Query: 299 CEAMEYLE--GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPE 356 +E++ R+ + V +++D AKVSD +A T Sbjct: 155 AYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTN--------- 205 Query: 357 ALREKKFSTKSD--VWSFGILLWEIYSFGRVPYPRI--PLKDVVPR-VEKGYKMDA---- 407 E FS + V +G++L EI + GRVP PL++ V R E G +++ Sbjct: 206 --NELAFSPDMEDIVRKYGMVLLEILT-GRVPSSEDDGPLENWVSRYFEGGMRLEELIDP 262 Query: 408 -----PDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 P+ A+ +V+++C D RP ++ ++ I Sbjct: 263 SIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEVAARMREI 303 >2RIO-A nrPDB Length = 434 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/226 (24%), Positives = 95/226 (42%), Gaps = 43/226 (19%) Query: 199 QTIGKGEFGDVML-GDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVE 257 + +G G G V+ G ++G VAVK + D A + + H N+++ Sbjct: 21 KILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETT 80 Query: 258 EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD---------VCEAMEYLEGN 308 ++ LYI E + +L D + S+ S D LK + + + +L Sbjct: 81 DRF-LYIALE-LCNLNLQDLVESKNVS----DENLKLQKEYNPISLLRQIASGVAHLHSL 134 Query: 309 NFVHRDLAARNVLVS-------------EDNVAKVSDFGLTKEASSTQDTGKLPVK---- 351 +HRDL +N+LVS E+ +SDFGL K+ S Q + + + Sbjct: 135 KIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSG 194 Query: 352 ---WTAPEALRE-------KKFSTKSDVWSFGILLWEIYSFGRVPY 387 W APE L E ++ + D++S G + + I S G+ P+ Sbjct: 195 TSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF 240 >4IDT-A nrPDB Length = 356 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/185 (30%), Positives = 80/185 (43%), Gaps = 23/185 (12%) Query: 201 IGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE 258 +G+G FG+V M G + AVK ++ + L + +T R +V L G V E Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPR---IVPLYGA-VRE 137 Query: 259 KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAAR 318 + I E + GSL ++ +G L D L + E +EYL +H D+ A Sbjct: 138 GPWVNIFMELLEGGSLGQLVKEQG--CLPEDRALYYLGQALEGLEYLHSRRILHGDVKAD 195 Query: 319 NVLVSEDNV-AKVSDFGLTKEASSTQDTG---------KLPVKWT--APEALREKKFSTK 366 NVL+S D A + DFG A Q G +P T APE + + K Sbjct: 196 NVLLSSDGSHAALCDFG---HAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAK 252 Query: 367 SDVWS 371 DVWS Sbjct: 253 VDVWS 257 >2EOB-A nrPDB Length = 124 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/100 (32%), Positives = 52/100 (52%), Gaps = 9/100 (9%) Query: 81 PWFHGKITREQAERLLYP-PETGLFLVR--ESTNYPGDYTLCVSCEGKVEHYRIMYHASK 137 PW++ +++R +AE +L P G FL+R E T+ Y + GKV+H RI Sbjct: 20 PWYYDRLSRGEAEDMLMRIPRDGAFLIRKREGTD---SYAITFRARGKVKHCRINRDGRH 76 Query: 138 LSIDEEVYFENLMQLVEHYTTDADGLCTRL---IKPKVME 174 + YFE+L++LV +Y A RL + P+++E Sbjct: 77 FVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPELLE 116 >2I6L-A nrPDB Length = 320 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 46/187 (24%), Positives = 82/187 (43%), Gaps = 27/187 (14%) Query: 218 KVAVKCI--KNDATAQAFLAEASVMTQLRHSNLVQLLGVI-------------VEEKGGL 262 +VA+K I + + + L E ++ +L H N+V++ ++ + E + Sbjct: 38 RVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSV 97 Query: 263 YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV 322 YIV EYM D + L + F + ++Y+ N +HRDL N+ + Sbjct: 98 YIVQEYME----TDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFI 153 Query: 323 -SEDNVAKVSDFGLTK-----EASSTQDTGKLPVKW-TAPEALREKKFSTKS-DVWSFGI 374 +ED V K+ DFGL + + + L KW +P L TK+ D+W+ G Sbjct: 154 NTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGC 213 Query: 375 LLWEIYS 381 + E+ + Sbjct: 214 IFAEMLT 220 >3CXL-A nrPDB Length = 463 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 34/92 (36%), Positives = 47/92 (51%), Gaps = 9/92 (9%) Query: 83 FHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDE 142 FHG I+RE A++LL E G +L+RES PG YTL + + ++R+ Y Sbjct: 54 FHGMISREAADQLLIVAE-GSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFV--G 110 Query: 143 EVYFENLMQLVEHYTTDADGLCTRLIKPKVME 174 E FE++ LV DGL T I+ K E Sbjct: 111 EKRFESIHDLV------TDGLITLYIETKAAE 136 >3PS5-A nrPDB Length = 595 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 33/103 (32%), Positives = 50/103 (48%), Gaps = 14/103 (13%) Query: 82 WFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSCEG---------KVEHYRI 131 W+HG ++ QAE LL E FLVRES + PGD+ L V + +V H ++ Sbjct: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 Query: 132 MYHASKLSIDEEVYFENLMQLVEHYTT----DADGLCTRLIKP 170 M + ++ F++L LVEH+ +A G L +P Sbjct: 170 MCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 32/99 (32%), Positives = 42/99 (42%), Gaps = 7/99 (7%) Query: 79 LMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASK 137 ++ WFH ++ AE LL G FL R S GD++L V +V H RI Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 Query: 138 LSIDEEVYFENLMQLVEHYT------TDADGLCTRLIKP 170 + F L +LVE+YT D DG L P Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 >2B3O-A nrPDB Length = 532 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 10/85 (11%) Query: 82 WFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSCEG---------KVEHYRI 131 W+HG ++ QAE LL E FLVRES + PGD+ L V + +V H ++ Sbjct: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 Query: 132 MYHASKLSIDEEVYFENLMQLVEHY 156 M + ++ F++L LVEH+ Sbjct: 170 MCEGGRYTVGGLETFDSLTDLVEHF 194 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 32/99 (32%), Positives = 42/99 (42%), Gaps = 7/99 (7%) Query: 79 LMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASK 137 ++ WFH ++ AE LL G FL R S GD++L V +V H RI Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 Query: 138 LSIDEEVYFENLMQLVEHYT------TDADGLCTRLIKP 170 + F L +LVE+YT D DG L P Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 >6HV0-A nrPDB Length = 416 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 90/203 (44%), Gaps = 18/203 (8%) Query: 200 TIGKGEFGDVML-GDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE 258 +G G G ++ G + VAVK I + + A + H N+++ ++ Sbjct: 15 VLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYF-CTEKD 73 Query: 259 KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAAR 318 + YI E A +L +Y+ + + LG + + + +L N VHRDL Sbjct: 74 RQFQYIAIELCA-ATLQEYVEQKDFAHLGLEPITLLQ-QTTSGLAHLHSLNIVHRDLKPH 131 Query: 319 NVLVSEDNV-----AKVSDFGLTKEAS----STQDTGKLPVK--WTAPEALRE--KKFST 365 N+L+S N A +SDFGL K+ + S +P W APE L E K+ T Sbjct: 132 NILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPT 191 Query: 366 KS-DVWSFGILLWEIYSFGRVPY 387 + D++S G + + + S G P+ Sbjct: 192 YTVDIFSAGCVFYYVISEGSHPF 214 >2PLE-A nrPDB Length = 105 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 3/76 (3%) Query: 82 WFHGKITREQAERLLYP-PETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSI 140 W+H +TR QAE +L P G FLVR+ N P Y + EGK++H R+ + + Sbjct: 11 WYHASLTRAQAEHMLMRVPRDGAFLVRK-RNEPNSYAISFRAEGKIKHCRVQQEGQTVML 69 Query: 141 DEEVYFENLMQLVEHY 156 F++L+ L+ +Y Sbjct: 70 GNSE-FDSLVDLISYY 84 >5M6U-B nrPDB Length = 724 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 1/92 (1%) Query: 70 GVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRE-STNYPGDYTLCVSCEGKVEH 128 G+ L W+ G I+RE+ L G FLVR+ ST GDYTL + G + Sbjct: 321 GMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKL 380 Query: 129 YRIMYHASKLSIDEEVYFENLMQLVEHYTTDA 160 +I + K + + F ++++L+ HY ++ Sbjct: 381 IKIFHRDGKYGFSDPLTFSSVVELINHYRNES 412 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 28/76 (36%), Positives = 37/76 (48%), Gaps = 2/76 (2%) Query: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSID 141 W G R +AE LL G FLVRES+ G Y V +G+V+H I A+ Sbjct: 624 WNVGSSNRNKAENLLRGKRDGTFLVRESSK-QGCYACSVVVDGEVKHCVINKTATGYGFA 682 Query: 142 EEV-YFENLMQLVEHY 156 E + +L +LV HY Sbjct: 683 EPYNLYSSLKELVLHY 698 >6BXI-A nrPDB Length = 333 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 49/235 (20%), Positives = 99/235 (42%), Gaps = 48/235 (20%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQA-----FLAEASVMTQ 242 L +++ + L+ IG+G FG+V L + G+ A+K ++ + AE ++ + Sbjct: 3 LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE 62 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 +V++ ++K LY++ E++ G ++ L + L + + + A+ Sbjct: 63 ADSLWVVKMF-YSFQDKLNLYLIMEFLPGGDMMTLLMKK--DTLTEEETQFYIAETVLAI 119 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT---KEASSTQD----TGKLPVKWT-- 353 + + F+HRD+ N+L+ K+SDFGL K+A T+ LP +T Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 354 -----------------------------APEALREKKFSTKSDVWSFGILLWEI 379 APE + ++ D WS G++++E+ Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEM 234 >4Y83-A nrPDB Length = 332 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 57/243 (23%), Positives = 107/243 (44%), Gaps = 21/243 (8%) Query: 201 IGKGEFGDVMLG-DYRGNK-VAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE 258 I +G FG V L D + K +A K I D Q ++ + RH N+ +L G ++ Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVD---QFKPSDVEIQACFRHENIAELYGAVLWG 137 Query: 259 KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAAR 318 + +++ E GS+++ L S G + ++ + V + +++L +H D+ Sbjct: 138 ET-VHLFMEAGEGGSVLEKLESCGP--MREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 194 Query: 319 NVLVSEDNVAKVSDFGL----TKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI 374 N++ V DFGL T++ +D + + +PE + + STK+D++S G Sbjct: 195 NIVFMSTKAVLV-DFGLSVQMTEDVYFPKDLRGTEI-YMSPEVILCRGHSTKADIYSLGA 252 Query: 375 LLWEIYSFGRVP----YPRIPLKDVVPRVEKGYKM--DAPDGCPPAVYDVMKNCWHLDAA 428 L + + G P YPR + + K D D C P + ++++ + Sbjct: 253 TLIHMQT-GTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPN 311 Query: 429 TRP 431 RP Sbjct: 312 HRP 314 >1XA6-A nrPDB Length = 466 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 36/92 (39%), Positives = 51/92 (55%), Gaps = 9/92 (9%) Query: 83 FHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDE 142 FHG I+REQA+ LL E G +++RES PG YTL + + +YR ++H K + E Sbjct: 58 FHGIISREQADELLGGVE-GAYILRESQRQPGCYTLALRFGNQTLNYR-LFHDGKHFVGE 115 Query: 143 EVYFENLMQLVEHYTTDADGLCTRLIKPKVME 174 + FE++ LV DGL T I+ K E Sbjct: 116 K-RFESIHDLV------TDGLITLYIETKAAE 140 >4G3E-A nrPDB Length = 352 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 53/184 (28%), Positives = 74/184 (40%), Gaps = 21/184 (11%) Query: 201 IGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQ-LRHSNLVQLLGVIVEEK 259 +G+G FG+V + + +C + F E V L +V L G V E Sbjct: 82 VGRGSFGEVH--RMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSPRIVPLYGA-VREG 138 Query: 260 GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARN 319 + I E + GSL ++ G L D L + E +EYL +H D+ A N Sbjct: 139 PWVNIFMELLEGGSLGQLIKQMG--CLPEDRALYYLGQALEGLEYLHTRRILHGDVKADN 196 Query: 320 VLVSEDNV-AKVSDFGLTKEASSTQDTG---------KLPVKWT--APEALREKKFSTKS 367 VL+S D A + DFG A Q G +P T APE + K K Sbjct: 197 VLLSSDGSRAALCDFG---HALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKV 253 Query: 368 DVWS 371 D+WS Sbjct: 254 DIWS 257 >4PL5-B nrPDB Length = 435 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 89/203 (43%), Gaps = 18/203 (8%) Query: 200 TIGKGEFGDVML-GDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE 258 +G G G ++ G + VAVK I + + A + H N+++ ++ Sbjct: 34 VLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYF-CTEKD 92 Query: 259 KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAAR 318 + YI E A +L +Y+ + + LG + + + +L N VHRDL Sbjct: 93 RQFQYIAIELCA-ATLQEYVEQKDFAHLGLEPITLLH-QTTSGLAHLHSLNIVHRDLKPH 150 Query: 319 NVLVSEDNV-----AKVSDFGLTKE-----ASSTQDTGKLPVK-WTAPEALREKKFSTKS 367 N+L+S N A +SDFGL K+ S ++ +G + W APE L E + Sbjct: 151 NILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPT 210 Query: 368 ---DVWSFGILLWEIYSFGRVPY 387 D++S G + + + S G P+ Sbjct: 211 YTVDIFSAGCVFYYVISEGYHPF 233 >3M42-A nrPDB Length = 299 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 22/119 (18%) Query: 262 LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVL 321 L IV E + G L ++ RG + + EA++YL N HRD+ N+L Sbjct: 90 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 149 Query: 322 VSE---DNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLW 377 + + + K++DFG KE + +K+ D+WS G++++ Sbjct: 150 YTSKRPNAILKLTDFGFAKETTG-------------------EKYDKSCDMWSLGVIMY 189 >6CKI-A nrPDB Length = 316 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 23/145 (15%) Query: 262 LYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320 Y+V E M GS++ ++ R + L +++ DV A+++L HRDL N+ Sbjct: 86 FYLVFEKMRGGSILSHIHKRRHFNELEASVVVQ---DVASALDFLHNKGIAHRDLKPENI 142 Query: 321 LVSEDNV---AKVSDFGLTKEASSTQDTGKLPV----------KWTAP---EALREKK-- 362 L N K+ DFGL D + ++ AP EA E+ Sbjct: 143 LCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASI 202 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPY 387 + + D+WS G++L+ + S G P+ Sbjct: 203 YDKRCDLWSLGVILYILLS-GYPPF 226 >2PMN-X nrPDB Length = 348 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 49/230 (21%), Positives = 101/230 (43%), Gaps = 41/230 (17%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK--------------NDATA-----QA 232 + + ++++T+ +G+F ++L + A+K + ND + Sbjct: 30 INDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDD 89 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD--- 289 F E ++T +++ + G+I +YI+ EYM S++ + VL + Sbjct: 90 FKNELQIITDIKNEYCLTCEGIITNY-DEVYIIYEYMENDSILKF--DEYFFVLDKNYTC 146 Query: 290 --------CLLKFSLDVCEAMEYLEG-NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 C++K V + Y+ N HRD+ N+L+ ++ K+SDFG ++ Sbjct: 147 FIPIQVIKCIIK---SVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMV 203 Query: 341 STQDTG-KLPVKWTAPEAL-REKKFS-TKSDVWSFGILLWEIYSFGRVPY 387 + G + ++ PE E ++ K D+WS GI L+ ++ + VP+ Sbjct: 204 DKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMF-YNVVPF 252 >4RC3-A nrPDB Length = 289 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 62/273 (22%), Positives = 116/273 (42%), Gaps = 36/273 (13%) Query: 191 NMKELKLLQT-------IGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ--------AF 233 +MKE + L++ +G G FG V G + VA+K ++ D + Sbjct: 3 HMKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 62 Query: 234 LAEASVMTQLRH--SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCL 291 E ++ ++ S +++LL + I+ L D++ RG L + Sbjct: 63 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELA 120 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSED-NVAKVSDFG---LTKEASSTQDTGK 347 F V EA+ + +HRD+ N+L+ + K+ DFG L K+ T G Sbjct: 121 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGT 180 Query: 348 LPVKWTAPEALREKKFSTKS-DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 ++ PE +R ++ +S VWS GILL+++ G +P+ + + R + ++ Sbjct: 181 R--VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQR 234 Query: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 C +++ C L + RPTF +++ Sbjct: 235 VSSEC----QHLIRWCLALRPSDRPTFEEIQNH 263 >1NRV-A nrPDB Length = 105 Score = 47.8 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 28/93 (30%), Positives = 53/93 (56%), Gaps = 7/93 (7%) Query: 82 WFHGKITREQAERLLYPPE--TGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY----HA 135 WFHG+I+RE++ R++ GLFL+R+S + P + L + K+++++I+ Sbjct: 7 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 66 Query: 136 SKLSIDE-EVYFENLMQLVEHYTTDADGLCTRL 167 + S+D+ F +L+QLV+ Y + L +L Sbjct: 67 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 99 >2VD5-A nrPDB Length = 412 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/217 (21%), Positives = 93/217 (42%), Gaps = 23/217 (10%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKN-----DATAQAFLAEASVMTQ 242 L + ++L+ IG+G F +V + + G A+K + F E V+ Sbjct: 58 LQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN 117 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEA 301 + QL +++ LY+V EY G L+ L G + + +F L ++ A Sbjct: 118 GDRRWITQL-HFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE--MARFYLAEIVMA 174 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTAPEA 357 ++ + +VHRD+ N+L+ +++DFG L + + + +PE Sbjct: 175 IDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEI 234 Query: 358 LR-------EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 L+ + + D W+ G+ +E++ +G+ P+ Sbjct: 235 LQAVGGGPGTGSYGPECDWWALGVFAYEMF-YGQTPF 270 >5AIR-A nrPDB Length = 430 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 85/193 (44%), Gaps = 14/193 (7%) Query: 199 QTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 + IG G FG V G VA+K + D + E +M +L H N+V+L Sbjct: 70 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--RELQIMRKLDHCNIVRLRYFFY 127 Query: 257 ---EEKGGLYI--VTEYMAKGSL-VDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 E+K +Y+ V +Y+ + V SR + L + + + ++ Y+ Sbjct: 128 SSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI 187 Query: 311 VHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKLPVK--WTAPEAL-REKKFSTK 366 HRD+ +N+L+ D V K+ DFG K+ + + APE + +++ Sbjct: 188 CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS 247 Query: 367 SDVWSFGILLWEI 379 DVWS G +L E+ Sbjct: 248 IDVWSAGCVLAEL 260 >2CRH-A nrPDB Length = 138 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 42/88 (47%) Query: 77 LSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS 136 LS+ W+ G + R AE +L G FLVR+ ++ + + +V+H +IM Sbjct: 23 LSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEG 82 Query: 137 KLSIDEEVYFENLMQLVEHYTTDADGLC 164 I E+ F L +LVE Y ++ C Sbjct: 83 LYRITEKKAFRGLTELVEFYQQNSLKDC 110 >3BGP-A nrPDB Length = 333 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/256 (22%), Positives = 108/256 (42%), Gaps = 29/256 (11%) Query: 201 IGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ--------AFLAEASVMTQLRH--SNL 248 +G G FG V G + VA+K ++ D + E ++ ++ S + Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 123 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 ++LL + I+ L D++ RG L + F V EA+ + Sbjct: 124 IRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNC 181 Query: 309 NFVHRDLAARNVLVSED-NVAKVSDFG---LTKEASSTQDTGKLPVKWTAPEALREKKFS 364 +HRD+ N+L+ + K+ DFG L K+ T G ++ PE +R ++ Sbjct: 182 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTR--VYSPPEWIRYHRYH 239 Query: 365 TKS-DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 +S VWS GILL+++ G +P+ + + R + ++ C +++ C Sbjct: 240 GRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQRVSSEC----QHLIRWCL 291 Query: 424 HLDAATRPTFLQLREQ 439 L + RPTF +++ Sbjct: 292 ALRPSDRPTFEEIQNH 307 >5TUR-A nrPDB Length = 404 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/256 (22%), Positives = 107/256 (41%), Gaps = 29/256 (11%) Query: 201 IGKGEFGDVMLGDYRGNK--VAVKCIKND--------ATAQAFLAEASVMTQLRH--SNL 248 +G G FG V G + VA+K ++ D E ++ ++ S + Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 194 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 ++LL + I+ L D++ RG L + F V EA+ + Sbjct: 195 IRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNC 252 Query: 309 NFVHRDLAARNVLVSEDN-VAKVSDFG---LTKEASSTQDTGKLPVKWTAPEALREKKFS 364 +HRD+ N+L+ + K+ DFG L K+ T G ++ PE +R ++ Sbjct: 253 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTR--VYSPPEWIRYHRYH 310 Query: 365 TKS-DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 +S VWS GILL+++ G +P+ + + R + ++ C +++ C Sbjct: 311 GRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQRVSSEC----QHLIRWCL 362 Query: 424 HLDAATRPTFLQLREQ 439 L + RPTF +++ Sbjct: 363 ALRPSDRPTFEEIQNH 378 >5GZA-A nrPDB Length = 290 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 47/81 (58%), Gaps = 3/81 (3%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 ++ ++ IG+G V L +++G KVA+ + +D A FL S++ L+ S++V L+GV Sbjct: 27 VRRVKLIGQGAVKKVYLSEWQGQKVALSVLSSDQYADDFLHGLSMLRALQSSHVVTLVGV 86 Query: 255 IVEEKGGLYIVTEYMAKGSLV 275 E+ VTEY GS++ Sbjct: 87 CEEDA---VFVTEYHPLGSVL 104 >2LCT-A nrPDB Length = 107 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 26/90 (28%), Positives = 43/90 (47%) Query: 77 LSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS 136 LS+ W+ G + R AE +L G FLVR+ ++ + + +V+H +IM Sbjct: 6 LSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEG 65 Query: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTR 166 I E+ F L +LVE Y ++ C + Sbjct: 66 LYRITEKKAFRGLTELVEFYQQNSLKDCFK 95 >2CT4-A nrPDB Length = 70 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 35/61 (57%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 C+A Y+F G++E + +G+ L+++ K W + + K G EG +P +Y++ G + Sbjct: 10 CVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTSGPSS 69 Query: 74 G 74 G Sbjct: 70 G 70 >5X1R-A nrPDB Length = 302 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 66/294 (22%), Positives = 125/294 (42%), Gaps = 51/294 (17%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLG-DYRGNK-VAVK-------CIKND--------- 227 SG+ N E ++ + IG+G FG V D++ + +A+K +ND Sbjct: 16 SGYRFN--EFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGE 73 Query: 228 -------ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS 280 A +F+ EA ++ + H L+ +L EE G Y+ T++ + G+ + L++ Sbjct: 74 RFGKTFQAGLNSFIQEARLLARFSHPGLLHVL-RFWEENGTAYMGTQFYS-GTTLKNLQA 131 Query: 281 RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT-KEA 339 + + + + + A+ + ++HRD++ N+ + E + + DFG KE Sbjct: 132 QQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEI 191 Query: 340 SSTQDTGKLPVKWTAPEALREKKFSTKSD----VWSFGILLWEIYSFGRVPYPRI----P 391 + D ++ +K P ++++ SD W+ +IY+ G V + I P Sbjct: 192 GNLSDETEIVLK---PGFAPIEQYTENSDGEQGPWT------DIYALGAVLHTLIVGSPP 242 Query: 392 LKDVVPRVEKGYK---MDAPDGCPPAVYDVMKNCWHLDAATRP-TFLQLREQLE 441 VV +E Y+ P G P + + L RP T ++ E LE Sbjct: 243 PVSVVRSIEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >5VC6-A nrPDB Length = 289 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 69/272 (25%), Positives = 103/272 (37%), Gaps = 35/272 (12%) Query: 194 ELKLLQTIGKGEFGDV------MLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL-RHS 246 E L+ IG GEFG V + G K + K + Q L E L +HS Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVCEAMEY 304 ++V+ E+ L I EY GSL D + R S L L V + Y Sbjct: 72 HVVRYFSAWAEDDHML-IQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 305 LEGNNFVHRDLAARNVLVS-------------EDNVA------KVSDFGLTKEASSTQDT 345 + + VH D+ N+ +S ED+ A K+ D G SS Q Sbjct: 131 IHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ-V 189 Query: 346 GKLPVKWTAPEALREK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404 + ++ A E L+E K+D+ F + L + + G P PR D + +G Sbjct: 190 EEGDSRFLANEVLQENYTHLPKADI--FALALTVVCAAGAEPLPRN--GDQWHEIRQGRL 245 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 P +++K H D RP+ + L Sbjct: 246 PRIPQVLSQEFTELLKVMIHPDPERRPSAMAL 277 >3LLT-A nrPDB Length = 360 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 49/230 (21%), Positives = 98/230 (42%), Gaps = 34/230 (14%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKN-DATAQAFLAEASVM 240 ++ G LN L +++ +G G FG V+L + NK AVK ++N ++ EA ++ Sbjct: 27 WKKGMLLNNAFL-VIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADIL 85 Query: 241 TQLRHSNLVQLLGVIVEEKGGLY----IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296 ++++ ++ V K Y ++ E + SL + + + + + + + Sbjct: 86 KKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPLGP-SLYEIITRNNYNGFHIEDIKLYCI 144 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLV-------------------------SEDNVAKVS 331 ++ +A+ YL + H DL N+L+ ++ K+ Sbjct: 145 EILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLI 204 Query: 332 DFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYS 381 DFG S + ++ APE + + SD+WSFG +L E+Y+ Sbjct: 205 DFGCATFKSDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYT 254 >2YUP-A nrPDB Length = 90 Score = 45.4 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 22/55 (40%), Positives = 34/55 (61%), Gaps = 2/55 (3%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAK-NKVGREGIIPANYVQ 66 E +A+Y F G E +L F KG+ + ++ + NWY+ + GR+GI PA+YVQ Sbjct: 19 EAVAQYTFKGDLEVELSFRKGEHICLIRKVNE-NWYEGRITGTGRQGIFPASYVQ 72 >1KA6-A nrPDB Length = 128 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 31/97 (31%), Positives = 46/97 (47%), Gaps = 11/97 (11%) Query: 83 FHGKITREQAERLLYPPETGL---FLVRESTNYPGDYTLCVSCEGKVEHYRI------MY 133 +HGKI+RE E+LL TGL +L+R+S + PG Y LCV G + YR+ + Sbjct: 7 YHGKISRETGEKLLL--ATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSW 64 Query: 134 HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 A + YF + L+ + G+ L P Sbjct: 65 SAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYP 101 >2H34-A nrPDB Length = 309 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 89/208 (42%), Gaps = 25/208 (12%) Query: 196 KLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLA-----EASVMTQLRHSNL 248 +L + +G+G GDV + R VA+K + ++ EA +L+ ++ Sbjct: 37 RLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHV 96 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 V + E G LY+ + L LR +G L + + A++ Sbjct: 97 VPIHD-FGEIDGQLYVDMRLINGVDLAAMLRRQG--PLAPPRAVAIVRQIGSALDAAHAA 153 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD---------TGKLPVKWTAPEALR 359 HRD+ N+LVS D+ A + DFG+ AS+T D G L + APE Sbjct: 154 GATHRDVKPENILVSADDFAYLVDFGI---ASATTDEKLTQLGNTVGTL--YYMAPERFS 208 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 E + ++D+++ +L+E + G PY Sbjct: 209 ESHATYRADIYALTCVLYECLT-GSPPY 235 >5UV4-A nrPDB Length = 311 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 49/182 (26%), Positives = 81/182 (44%), Gaps = 17/182 (9%) Query: 229 TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYI-VTEYMAKGSLVDYLRS---RGRS 284 + + F E + +RH NLV L G K I +++Y SL YL R Sbjct: 64 SKKEFSREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLP 123 Query: 285 VLGGDCLLKFSLDVCEAMEYLEGNNFV-HRDLAARNVLVSEDN-VAKVSDFGLTK----- 337 L L ++D+ ++YL + H ++ + NVL+ A V+D+ L + Sbjct: 124 PLSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPI 183 Query: 338 -EASSTQDTGKLPVKWTAPEALREKKF--STKSDVWSFGILLWEIYSFGRVPYPRIPLKD 394 A + G L ++ PE K S KSDV++FG++L E+ + G++ I + D Sbjct: 184 GMAEQVLNAGAL--GYSPPEFSSTSKPCPSLKSDVYAFGVILLELLT-GKIAGEIICMND 240 Query: 395 VV 396 V Sbjct: 241 GV 242 >1M27-A nrPDB Length = 104 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 31/97 (31%), Positives = 46/97 (47%), Gaps = 11/97 (11%) Query: 83 FHGKITREQAERLLYPPETGL---FLVRESTNYPGDYTLCVSCEGKVEHYRI------MY 133 +HGKI+RE E+LL TGL +L+R+S + PG Y LCV G + YR+ + Sbjct: 7 YHGKISRETGEKLLL--ATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSW 64 Query: 134 HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 A + YF + L+ + G+ L P Sbjct: 65 SAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYP 101 >3EB0-A nrPDB Length = 383 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 55/239 (23%), Positives = 98/239 (41%), Gaps = 50/239 (20%) Query: 187 GWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLR 244 G + K+ L +T+G G FG V + G + A+K + D + E +M L Sbjct: 1 GLETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN--RELDIMKVLD 58 Query: 245 HSNLVQLL-----------------------------------GVIVEEKGGLY--IVTE 267 H N+++L+ VIV Y ++ E Sbjct: 59 HVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIME 118 Query: 268 YMA---KGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV-S 323 Y+ L ++RS GRS+ + + + + A+ ++ HRD+ +N+LV S Sbjct: 119 YVPDTLHKVLKSFIRS-GRSI-PMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNS 176 Query: 324 EDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPE-ALREKKFSTKSDVWSFGILLWEI 379 +DN K+ DFG K+ ++ + + APE L +++ D+WS G + E+ Sbjct: 177 KDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGEL 235 >5VD3-A nrPDB Length = 311 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 37/134 (27%), Positives = 63/134 (47%), Gaps = 7/134 (5%) Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLA 316 EE G LY+ TE + SL + + G S+ + + D A+ +L VH D+ Sbjct: 127 EEGGILYLQTE-LCGPSLQQHCEAWGASLPEAQ-VWGYLRDTLLALAHLHSQGLVHLDVK 184 Query: 317 ARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP---VKWTAPEALREKKFSTKSDVWSFG 373 N+ + K+ DFGL E T G++ ++ APE L + + T +DV+S G Sbjct: 185 PANIFLGPRGRCKLGDFGLLVEL-GTAGAGEVQEGDPRYMAPELL-QGSYGTAADVFSLG 242 Query: 374 ILLWEIYSFGRVPY 387 + + E+ +P+ Sbjct: 243 LTILEVACNMELPH 256 >5FQD-C nrPDB Length = 341 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 67/290 (23%), Positives = 109/290 (37%), Gaps = 35/290 (12%) Query: 173 MEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATA 230 M + ++ EF G + KL++ IG G FGD+ L G +VAVK A Sbjct: 5 MASSSGSKAEFIVGG------KYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARH 58 Query: 231 QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC 290 L E+ + L+ + + +EK +V + + SL D R Sbjct: 59 PQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGP-SLEDLFNFCSRRFTMKTV 117 Query: 291 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGK 347 L+ + + +EY+ NF+HRD+ N L+ N + DFGL K+ + Sbjct: 118 LM-LADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQH 176 Query: 348 LP----------VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVP 397 +P ++ + A + S + D+ S G +L F R P LK Sbjct: 177 IPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM---YFNRTSLPWQGLKAATK 233 Query: 398 RVE----KGYKMDAP-----DGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 + + KM P G P + C L P ++ LR+ Sbjct: 234 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQ 283 >4LQP-A nrPDB Length = 508 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/163 (27%), Positives = 74/163 (45%), Gaps = 14/163 (8%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI------KNDATAQAFLAEASVMTQLR 244 ++ ++ IGKG FG+V L + G A+K + K D A AE V+ Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHV-KAERDVLAG-S 159 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC-EAME 303 S V L ++ LY++ E++ G L+ L R L + + +F + C A+E Sbjct: 160 DSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLI---RWQLFTEDVTRFYMAECILAIE 216 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG 346 + F+HR + N+L+ K+SDFGL+ T D+ Sbjct: 217 TIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSN 259 >4CRL-A nrPDB Length = 406 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/203 (21%), Positives = 89/203 (43%), Gaps = 22/203 (10%) Query: 201 IGKGEFGDV----MLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 +G+G +G V A+K I+ + + E +++ +L+H N++ L V + Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFL 89 Query: 257 EEKG-GLYIVTEYMAKG--SLVDYLRS---RGRSVLGGDCLLKFSL-DVCEAMEYLEGNN 309 ++++ +Y ++ + R+ + V ++K L + + + YL N Sbjct: 90 SHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANW 149 Query: 310 FVHRDLAARNVLV----SEDNVAKVSDFGLTKEASST------QDTGKLPVKWTAPEALR 359 +HRDL N+LV E K++D G + +S D + + APE L Sbjct: 150 VLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLL 209 Query: 360 EKKFSTKS-DVWSFGILLWEIYS 381 + TK+ D+W+ G + E+ + Sbjct: 210 GARHYTKAIDIWAIGCIFAELLT 232 >5GZ9-A nrPDB Length = 305 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/159 (26%), Positives = 75/159 (47%), Gaps = 7/159 (4%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLG 253 E++ L+ +G+G V L +++ +KVA+ + + FL ++ L+ ++V L+G Sbjct: 35 EVRQLKRVGEGAVKRVFLSEWKEHKVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVG 94 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 EE G I+TEY GSL + + S + L + AMEY+ N++H Sbjct: 95 -YCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQL--AMEYVSIINYLHH 149 Query: 314 DLAARNVLVSEDNVAK-VSDFGLTKEAS-STQDTGKLPV 350 V+ +++ K +S + LT S D LP+ Sbjct: 150 SPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPL 188 >4TN6-A nrPDB Length = 318 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 66/286 (23%), Positives = 110/286 (38%), Gaps = 57/286 (19%) Query: 196 KLLQTIGKGEFGDVMLGD--YRGNKVAVK--CIKNDATAQAFLAEASVMTQLRHSNLVQL 251 +L + IG G FGD+ LG G +VA+K C+K ++ M Q Sbjct: 10 RLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ--------- 60 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDY----LRSRGRSV--LGGDCLLKFSL--------D 297 GG+ I T G+ DY + G S+ L C KFSL Sbjct: 61 --------GGVGIPTIRWC-GAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQ 111 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLP----- 349 + +EY+ NF+HRD+ N L+ + N+ + DFGL K+ + +P Sbjct: 112 MISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENK 171 Query: 350 -----VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK--G 402 ++ + + S + D+ S G +L ++ G +P+ + + E+ Sbjct: 172 NLTGTARYASINTHLGIEQSRRDDLESLGYVLM-YFNLGSLPWQGLKAATKRQKYERISE 230 Query: 403 YKMDAP-----DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 KM P G P + C L +P + LR+ ++ Sbjct: 231 KKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNL 276 >2VIF-A nrPDB Length = 141 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 3/89 (3%) Query: 76 KLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHA 135 KL+ W+ G ITR +AE L G FLVR+S++ +L GK H RI + Sbjct: 20 KLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSN 79 Query: 136 SKLSIDEEVYFE---NLMQLVEHYTTDAD 161 + S E+ E +++ L+EH D++ Sbjct: 80 GRFSFYEQPDVEGHTSIVDLIEHSIGDSE 108 >6O6Q-A nrPDB Length = 335 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/192 (23%), Positives = 96/192 (50%), Gaps = 20/192 (10%) Query: 196 KLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHS-NLVQLL 252 ++L+ +G+G++ +V LG + KV +K +K + E S++ L N++ +L Sbjct: 44 EILRKLGRGKYSEVFLGIDLEKREKVVIKVLK-PVKRKKIKREISILKNLVDGPNIIAML 102 Query: 253 GVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEYLEGN 308 V+ E + GL + E++ +D+ R D ++F + ++ +A++Y Sbjct: 103 DVVREPQSKTPGL--IFEHINN---IDF---RSLYPTFTDYDIRFYMYELLKALDYSHSM 154 Query: 309 NFVHRDLAARNVLVSED-NVAKVSDFGLTKEAS-STQDTGKLPVKW-TAPEALREKKFST 365 +HRD+ NV++ D + ++ D+GL + T+ ++ ++ PE L + + Sbjct: 155 GIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRLYD 214 Query: 366 KS-DVWSFGILL 376 S D+WSFG +L Sbjct: 215 YSLDMWSFGCML 226 >5CLR-A nrPDB Length = 451 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 27/192 (14%) Query: 216 GNKVAVKCIKNDA-TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSL 274 G +K +K DA + F E + S L +L+G E+ ++ + KG Sbjct: 104 GKTYFLKSVKIDAESLTEFTNEKDTL-----SKLGRLVGTFFNEQTQVHYILTTFIKG-- 156 Query: 275 VDYLRSRGRSVLGGDC-----LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAK 329 +D R + L + +L + VC ++ +HRDL N+++ D Sbjct: 157 IDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCH 216 Query: 330 VSDFGLTKEASSTQDTGKLPVKW-----TAPEALREKK---FSTKSDVWSFGILLWEIYS 381 + DFG SS+ D P W APE ++ FS SD+++ L E+++ Sbjct: 217 LVDFG-----SSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSLDELFN 271 Query: 382 -FGRVPYPRIPL 392 F +V + ++ + Sbjct: 272 PFRQVKFAKVDI 283 >2CS0-A nrPDB Length = 119 Score = 42.0 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 21/50 (42%), Positives = 28/50 (56%), Gaps = 1/50 (2%) Query: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRI 131 WFHG I+RE AE LL G FL+R S ++ G YTL + H+ + Sbjct: 18 WFHGAISREDAENLLESQPLGSFLIRVSHSHVG-YTLSYKAQSSCCHFMV 66 >5L2Q-C nrPDB Length = 320 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 13/108 (12%) Query: 297 DVCEAMEYLEGNNFVHRDLAARN-VLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVK 351 DV +E L N VHRDL N VL + +++F L K E +D P Sbjct: 161 DVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPA- 219 Query: 352 WTAPEALREKKFSTK-SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 + +P+ L + + K SD+W+ G++L+ + Y + P D +P+ Sbjct: 220 YISPDVLSGRPYRGKPSDMWALGVVLFTML------YGQFPFYDSIPQ 261 >5VEI-A nrPDB Length = 110 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 2/61 (3%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGT 75 A Y+F ++L F KGD + I+ D NWY+ ++ GR GI P +YV+K G A Sbjct: 39 AVYDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHH-GRVGIFPISYVEKLTGSAAAL 96 Query: 76 K 76 + Sbjct: 97 R 97 >2DLM-A nrPDB Length = 68 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 2/69 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYV 65 +S SG K++F + ++L KGD++ I D NW + ++ GR GI PANYV Sbjct: 2 SSGSSGKAARLKFDFQAQSPKELTLQKGDIVYIHKEV-DKNWLEGEHH-GRLGIFPANYV 59 Query: 66 QKREGVKAG 74 + G +G Sbjct: 60 EVLSGPSSG 68 >5O0Y-A nrPDB Length = 579 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/171 (23%), Positives = 71/171 (41%), Gaps = 22/171 (12%) Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E + +L H +V+L + V EY L YL+ ++ Sbjct: 338 EYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH--KLMSEKEARSII 395 Query: 296 LDVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVA---KVSDFGLTK----EASSTQDTG 346 + + A++YL +H DL N+L+ K++DFGL+K ++ ++ D Sbjct: 396 MQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGM 455 Query: 347 KLPVK------WTAPEAL----REKKFSTKSDVWSFGILLWEIYSFGRVPY 387 +L + + PE K S K DVWS G++ ++ +GR P+ Sbjct: 456 ELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCL-YGRKPF 505 >2HW6-A nrPDB Length = 307 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/211 (22%), Positives = 89/211 (42%), Gaps = 25/211 (11%) Query: 199 QTIGKGEFGDVM--LGDYRGNKVAVKCIKNDA--TAQAFLAEASVMTQLRHSNLVQLLGV 254 + +G+G + V + G + AVK I+ A + E + Q + + + L Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIE 78 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 E+ Y+V E + GS++ +++ + + DV A+++L HRD Sbjct: 79 FFEDDTRFYLVFEKLQGGSILAHIQKQKH--FNEREASRVVRDVAAALDFLHTKGIAHRD 136 Query: 315 LAARNVLV-SEDNVA--KVSDFGL----------TKEASSTQDTGKLPVKWTAPEAL--- 358 L N+L S + V+ K+ DF L T + T ++ APE + Sbjct: 137 LKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVF 196 Query: 359 --REKKFSTKSDVWSFGILLWEIYSFGRVPY 387 + + + D+WS G++L+ + S G P+ Sbjct: 197 TDQATFYDKRCDLWSLGVVLYIMLS-GYPPF 226 >3GF9-A nrPDB Length = 295 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 33/56 (58%), Gaps = 2/56 (3%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 G + IA Y++ E +L F KG ++ ++ DP+W++ + G G+ P+NYV+ Sbjct: 18 GCQVIAMYDYAANNEDELSFSKGQLINVMN-KDDPDWWQGEIN-GVTGLFPSNYVK 71 >4Y12-A nrPDB Length = 375 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 68/138 (49%), Gaps = 11/138 (7%) Query: 240 MTQLRHSNLVQLLGVI--VEEKGGL--YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 + ++ H ++VQ+ + + G YIV EY+ SL RS+G+ + + + + Sbjct: 172 LAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK---RSKGQKLPVAEAI-AYL 227 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAP 355 L++ A+ YL V+ DL N++++E+ + K+ D G +S P + AP Sbjct: 228 LEILPALSYLHSIGLVYNDLKPENIMLTEEQL-KLIDLGAVSRINSFGYLYGTP-GFQAP 285 Query: 356 EALREKKFSTKSDVWSFG 373 E +R + +D+++ G Sbjct: 286 EIVRTGP-TVATDIYTVG 302 >6C5X-D nrPDB Length = 164 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 1/58 (1%) Query: 102 GLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSID-EEVYFENLMQLVEHYTT 158 G FL+R+S + + V + RI +HA K S+D + F L QLVEHY T Sbjct: 52 GTFLIRDSKQKNCFFAISVKTARETVSIRIKFHAGKFSLDGSKELFSCLFQLVEHYMT 109 >6J6I-B nrPDB Length = 351 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 81/183 (44%), Gaps = 32/183 (17%) Query: 216 GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLV 275 G + VK + ND A ++ HSN +QLLG +E + +V E+ G++ Sbjct: 96 GKRHRVKEVYNDIVLSARMSN--------HSNFLQLLGCCLEFPFPV-LVFEFAEHGAM- 145 Query: 276 DYLRSRGRSVLGGD-------CLLKFSLDVCEAMEYLEG---NNFVHRDLAARNVLVSED 325 RG ++ G+ LK ++ A+ YL +HRD+ +V + ++ Sbjct: 146 ---NQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKN 202 Query: 326 NVAKVSDFGLTKEASSTQDTGKLPVKWTAP-----EALREKK-FSTK-SDVWSFGILLWE 378 AK+SD + S + ++ +W + L K F T+ +DV+SFGI L Sbjct: 203 WTAKLSDLSFS--ISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLV 260 Query: 379 IYS 381 I + Sbjct: 261 IIT 263 >2X3W-D nrPDB Length = 60 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 29/56 (51%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 G A Y++ G + +L F GD LT + + W + + G+ G+ PANYV+ Sbjct: 3 GVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 58 >5NXJ-A nrPDB Length = 60 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 2/59 (3%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKRE 69 G IA Y++ + ++ F D++T + + D W++ K GR G+ PANYV+ R+ Sbjct: 4 GITAIALYDYQAAGDDEISFDPDDIITNIEMIDD-GWWRGVCK-GRYGLFPANYVELRQ 60 >3ULR-B nrPDB Length = 65 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 2/59 (3%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKRE 69 G IA Y++ + ++ F D++T + + D W++ K GR G+ PANYV+ R+ Sbjct: 9 GITAIALYDYQAAGDDEISFDPDDIITNIEMIDD-GWWRGVCK-GRYGLFPANYVELRQ 65 >2PZI-A nrPDB Length = 681 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 68/138 (49%), Gaps = 11/138 (7%) Query: 240 MTQLRHSNLVQLLGVI--VEEKGGL--YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 + ++ H ++VQ+ + + G YIV EY+ SL RS+G+ + + + + Sbjct: 133 LAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK---RSKGQKLPVAEAI-AYL 188 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAP 355 L++ A+ YL V+ DL N++++E+ + K+ D G +S P + AP Sbjct: 189 LEILPALSYLHSIGLVYNDLKPENIMLTEEQL-KLIDLGAVSRINSFGYLYGTP-GFQAP 246 Query: 356 EALREKKFSTKSDVWSFG 373 E +R + +D+++ G Sbjct: 247 EIVRTGP-TVATDIYTVG 263 >3HAJ-A nrPDB Length = 486 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 2/59 (3%) Query: 10 SGTECIAK--YNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 SGTE + Y++ G +L F GD LT + + W K + G+ G+ PANYV+ Sbjct: 425 SGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVE 483 >1X69-A nrPDB Length = 79 Score = 38.9 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 18/59 (30%), Positives = 33/59 (55%), Gaps = 2/59 (3%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKRE 69 G +A Y++ + ++ F D++T + + D W++ K GR G+ PANYV+ R+ Sbjct: 17 GITAVALYDYQAAGDDEISFDPDDIITNIEMIDD-GWWRGVCK-GRYGLFPANYVELRQ 73 >3EHQ-A nrPDB Length = 222 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 20/53 (37%), Positives = 32/53 (60%), Gaps = 2/53 (3%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 A Y F +L +GD++ I ++ D NW+K +K GR G+IP+NYV ++ Sbjct: 19 ALYTFEPRTPDELYIEEGDIIYITDMS-DTNWWKGTSK-GRTGLIPSNYVAEQ 69 >4BNE-A nrPDB Length = 457 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 28/51 (54%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 A Y++ G + +L F GD LT + + W K + G+ G+ PANYV+ Sbjct: 404 ALYDYEGQEQDELSFKAGDELTKMENEDEQGWCKGRLDNGQVGLYPANYVE 454 >2CMW-A nrPDB Length = 310 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 70/166 (42%), Gaps = 12/166 (7%) Query: 195 LKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLL 252 +++ + IG G FG++ LG Y VA+K + A E QL + L Sbjct: 2 MRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAG-EGLP 60 Query: 253 GVIVEEKGGLY--IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 V G Y +V E + SL D R+ L+ ++ + MEY+ N Sbjct: 61 QVYYFGPCGKYNAMVLELLGP-SLEDLFDLCDRTFTLKTVLM-IAIQLLSRMEYVHSKNL 118 Query: 311 VHRDLAARNVLVS-----EDNVAKVSDFGLTKEASSTQDTGKLPVK 351 ++RD+ N L+ +++V + DFGL KE + +P + Sbjct: 119 IYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYR 164 >3JV3-A nrPDB Length = 283 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 33/54 (61%), Gaps = 2/54 (3%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 + I Y++ + +L F KG ++ ++ +DP+W+K + G+ G+ P+NYV+ Sbjct: 4 QVIGMYDYTAQNDDELAFSKGQIINVLN-KEDPDWWKGEVS-GQVGLFPSNYVK 55 >2NWM-A nrPDB Length = 65 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 2/50 (4%) Query: 17 KYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 K++F + ++L KGD++ I D NW + ++ GR GI PANYV+ Sbjct: 7 KFDFQAQSPKELTLQKGDIVYIHKEV-DKNWLEGEHH-GRLGIFPANYVE 54 >1WXU-A nrPDB Length = 93 Score = 37.4 bits (85), Expect = 0.015, Method: Composition-based stats. Identities = 24/76 (31%), Positives = 38/76 (50%), Gaps = 10/76 (13%) Query: 7 SWPSGTE----CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPN---WYKAKNKVGREGI 59 +W SG + A+Y+F +++++ F GD+L + + P W A G+ Sbjct: 9 NWASGEDDHVVARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGL 68 Query: 60 IPANYVQ---KREGVK 72 IPANYV+ KR G K Sbjct: 69 IPANYVKILGKRRGRK 84 >5M07-A nrPDB Length = 276 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 42/201 (20%), Positives = 83/201 (41%), Gaps = 25/201 (12%) Query: 197 LLQTIGKGEFGDVMLGDYRGNK--VAVKCIK-----NDATAQAFLAEASVMTQLRHSNLV 249 +++ +G G+V L + G A+K + +D + F E V +L H +++ Sbjct: 34 VVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPHIL 93 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 ++ E G L+I +Y+ ++ R +VL +L V A++Y Sbjct: 94 EVHDR-GEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRG 152 Query: 310 FVHRDLAARNVLVSEDNVAK----VSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFST 365 +HRD+ NV+++ + ++DFG+ + S + APE Sbjct: 153 LLHRDVNPANVVLTSQSAGDQRILLADFGIASQPS-----------YPAPELSAGADVDG 201 Query: 366 KSDVWSFGILLWEIYSFGRVP 386 ++D + + L I+ F P Sbjct: 202 RAD--QYALALTAIHLFAGAP 220 >6F55-A nrPDB Length = 67 Score = 37.0 bits (84), Expect = 0.018, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 28/57 (49%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQK 67 G A Y++ G +L F G+ L ++ + W K + G G+ PANYV+K Sbjct: 5 GVRVRALYDYTGQEADELSFKAGEELMKISEEDEQGWCKGRLLTGHVGLYPANYVEK 61 >2CR4-A nrPDB Length = 126 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 3/62 (4%) Query: 99 PETGLFLVRESTNYPGDYTLCV--SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156 P+ GL+ +R S+ G L V KV +YRI SK ++ EV F ++ +VEHY Sbjct: 42 PQDGLYCIRNSSTKSGK-VLVVWDETSNKVRNYRIFEKDSKFYLEGEVLFVSVGSMVEHY 100 Query: 157 TT 158 T Sbjct: 101 HT 102 >4XHH-A nrPDB Length = 403 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 57/271 (21%), Positives = 101/271 (37%), Gaps = 35/271 (12%) Query: 193 KELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQ 250 ++ ++ + IG G FGD+ G G +VA++ + E+ V L + Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIP 66 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 + E +V + + SL D R ++ +L + ++Y+ G +F Sbjct: 67 FIRWFGREGEYNAMVIDLLGP-SLEDLFNYCHRK-FSFKTVIMLALQMICRVQYIHGRSF 124 Query: 311 VHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLP----------VKWTAPEA 357 +HRD+ N L+ + V DFGL+K+ +P ++ + Sbjct: 125 IHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNT 184 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVP------------YPRIPLKDVVPRVEKGYKM 405 + S + D+ S G +L + G +P Y RI K + VE Sbjct: 185 HLGIEQSRRDDLESLGYMLI-YFCKGSLPWQGLKATTKKQKYDRILEKKLCISVET---- 239 Query: 406 DAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 G P + M C +L RP +L L Sbjct: 240 -LCAGLPLEFSEYMNYCRNLKFDERPDYLYL 269 >6DC0-A nrPDB Length = 292 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 70/152 (46%), Gaps = 16/152 (10%) Query: 245 HSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 HSN+ ++ VI+ E K ++ ++ G + Y+RSR R L + + + A+ Sbjct: 57 HSNITGIVEVILGETKAYVFFEKDF---GDMHSYVRSRKR--LREEEAARLFKQIVSAVA 111 Query: 304 YLEGNNFVHRDLAARNVLVSED-----NVAKVSDFGLTK-EASSTQDTGKLPVKWTAPEA 357 + + V DL R + S + + + D + K E + D P + +PE Sbjct: 112 HCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPA-YVSPEI 170 Query: 358 LREK-KFSTKS-DVWSFGILLWEIYSFGRVPY 387 L +S K+ DVWS G++L+ + GR P+ Sbjct: 171 LNTTGTYSGKAADVWSLGVMLYTLL-VGRYPF 201 >6C7Y-B nrPDB Length = 117 Score = 35.8 bits (81), Expect = 0.036, Method: Composition-based stats. Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 3/89 (3%) Query: 72 KAGTKLSLMPWFHGKITREQA-ERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 +A + L ++ G +T A E+L PE G FL+R+ST + + V R Sbjct: 18 RASSLLDACGFYWGPLTVSAAHEKLKSEPE-GTFLIRDSTQKNCFFAISVKTATGPTSIR 76 Query: 131 IMYHASKLSID-EEVYFENLMQLVEHYTT 158 I + + S+D + F+ L +L+EHY + Sbjct: 77 INFQTGRFSLDGSKETFDCLFKLLEHYLS 105 >3SV0-A nrPDB Length = 483 Score = 35.8 bits (81), Expect = 0.036, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 68/166 (40%), Gaps = 13/166 (7%) Query: 194 ELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSN---L 248 + +L + IG G FG++ LG +VA+K L E+ + L+ Sbjct: 8 KFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTGIPN 67 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 V+ GV +G ++ + SL D R L +L + + +E++ Sbjct: 68 VRWFGV----EGDYNVLVMDLLGPSLEDLFNFCSRK-LSLKTVLMLADQMINRVEFVHSK 122 Query: 309 NFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLPVK 351 +F+HRD+ N L+ N + DFGL K+ T +P + Sbjct: 123 SFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYR 168 >4JGH-A nrPDB Length = 173 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 46/95 (48%), Gaps = 11/95 (11%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKV--EH 128 KA +L W+ G +T +A+ L G FL+R+S++ DY L +S + + Sbjct: 12 AKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSH--SDYLLTISVKTSAGPTN 69 Query: 129 YRIMYHASKLSIDEEV-------YFENLMQLVEHY 156 RI Y K +D + F++++ L+++Y Sbjct: 70 LRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 104 >5CEK-A nrPDB Length = 263 Score = 35.8 bits (81), Expect = 0.040, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 70/152 (46%), Gaps = 16/152 (10%) Query: 245 HSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 HSN+ ++ VI+ E K ++ ++ G + Y+RSR R L + + + A+ Sbjct: 60 HSNITGIVEVILGETKAYVFFEKDF---GDMHSYVRSRKR--LREEEAARLFKQIVSAVA 114 Query: 304 YLEGNNFVHRDLAARNVLVSED-----NVAKVSDFGLTK-EASSTQDTGKLPVKWTAPEA 357 + + V DL R + S + + + D + K E + D P + +PE Sbjct: 115 HCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPA-YVSPEI 173 Query: 358 LREK-KFSTKS-DVWSFGILLWEIYSFGRVPY 387 L +S K+ DVWS G++L+ + GR P+ Sbjct: 174 LNTTGTYSGKAADVWSLGVMLYTLL-VGRYPF 204 >4LFI-A nrPDB Length = 374 Score = 35.8 bits (81), Expect = 0.042, Method: Compositional matrix adjust. Identities = 36/149 (24%), Positives = 68/149 (45%), Gaps = 13/149 (8%) Query: 245 HSNLVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAM 302 H+N++ L +I + +V EY VD + R D ++F + ++ +A+ Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEY------VDNVDFRILYPKLTDLEIRFYMFELLKAL 185 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVA-KVSDFGLTK--EASSTQDTGKLPVKWTAPEALR 359 +Y +HRD+ NV++ N ++ D+GL + + + + PE L Sbjct: 186 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 245 Query: 360 EKKFSTKS-DVWSFGILLWEIYSFGRVPY 387 + + S D+WSFG +L + F R P+ Sbjct: 246 DYRMYDYSLDLWSFGTMLASM-IFKREPF 273 >5UU1-A nrPDB Length = 324 Score = 35.4 bits (80), Expect = 0.055, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 21/109 (19%) Query: 291 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKV--SDFGLT---------KEA 339 +L+ + + + +EY+ N +VH D+ A N+L+ N +V +D+GL+ K+ Sbjct: 132 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQY 191 Query: 340 SSTQDTG-KLPVKWTAPEALREKKFSTKSDV---------WSFGILLWE 378 G +++T+ +A + S +SDV W G L WE Sbjct: 192 QENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWE 240 >4XHL-A nrPDB Length = 394 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 34/166 (20%), Positives = 67/166 (40%), Gaps = 11/166 (6%) Query: 193 KELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQ 250 ++ ++ + IG G FGD+ G G +VA++ + E+ V L + Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIP 66 Query: 251 LLGVIVEEKGGLYIVTEYMAKG--SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 + E +V + + L +Y R ++ +L + ++Y+ G Sbjct: 67 FIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRR----FSFKTVIMLALQMFCRIQYIHGR 122 Query: 309 NFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLPVK 351 +F+HRD+ N L+ + V DFGL+K+ +P + Sbjct: 123 SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYR 168 >1NM7-A nrPDB Length = 69 Score = 35.0 bits (79), Expect = 0.059, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 4/46 (8%) Query: 25 EQDLPFCKGDVLTIVA----VTKDPNWYKAKNKVGREGIIPANYVQ 66 E ++ KGD++ I++ + +D +W+K + K G G IP NY++ Sbjct: 22 EMEVALKKGDLMAILSKKDPLGRDSDWWKVRTKNGNIGYIPYNYIE 67 >6EQI-C nrPDB Length = 433 Score = 35.0 bits (79), Expect = 0.061, Method: Compositional matrix adjust. Identities = 40/147 (27%), Positives = 64/147 (43%), Gaps = 31/147 (21%) Query: 300 EAMEYLEGNNFVHRDLAARNVLV--SEDNVAK---VSDFG----------LTKEASSTQD 344 EA+ ++ +N HRDL + N+LV SE + ++DFG + S QD Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQD 237 Query: 345 TGKLPVKWTAPEALREK--KFS----TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 G APE K FS KSD+W+ G + +EI++ Y + + Sbjct: 238 KGG-NRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDK-----TMKL 291 Query: 399 VEKGYKM----DAPDGCPPAVYDVMKN 421 + K YK + PD P + +++ N Sbjct: 292 LSKSYKEEDLPELPDTIPFIIRNLVSN 318 >2V1R-A nrPDB Length = 80 Score = 35.0 bits (79), Expect = 0.067, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 4/46 (8%) Query: 25 EQDLPFCKGDVLTIVA----VTKDPNWYKAKNKVGREGIIPANYVQ 66 E ++ KGD++ I++ + +D +W+K + K G G IP NY++ Sbjct: 29 EMEVALKKGDLMAILSKKDPLGRDSDWWKVRTKNGNIGYIPYNYIE 74 >1N5Z-A nrPDB Length = 92 Score = 35.0 bits (79), Expect = 0.068, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 4/46 (8%) Query: 25 EQDLPFCKGDVLTIVA----VTKDPNWYKAKNKVGREGIIPANYVQ 66 E ++ KGD++ I++ + +D +W+K + K G G IP NY++ Sbjct: 29 EMEVALKKGDLMAILSKKDPLGRDSDWWKVRTKNGNIGYIPYNYIE 74 >2C47-A nrPDB Length = 313 Score = 35.0 bits (79), Expect = 0.074, Method: Compositional matrix adjust. Identities = 37/160 (23%), Positives = 59/160 (36%), Gaps = 9/160 (5%) Query: 199 QTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 + IG G FG++ LG Y VA+K + A E QL + V V Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVP--QVYY 67 Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLA 316 G Y G ++ L +L ++ + MEY+ + ++RD+ Sbjct: 68 FGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVK 127 Query: 317 ARNVLVSEDNVAK-----VSDFGLTKEASSTQDTGKLPVK 351 N LV + + DFGL KE + +P + Sbjct: 128 PENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYR 167 >5NP2-A nrPDB Length = 61 Score = 34.7 bits (78), Expect = 0.081, Method: Composition-based stats. Identities = 15/51 (29%), Positives = 29/51 (56%), Gaps = 1/51 (1%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYV 65 +A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ Sbjct: 8 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYI 57 >2HMH-A nrPDB Length = 152 Score = 34.7 bits (78), Expect = 0.082, Method: Compositional matrix adjust. Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 18/124 (14%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 V A KL ++ +T +A LL G FL+R+S++ +TL V + ++ R Sbjct: 25 VNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLR 84 Query: 131 IMYHASKLSIDEE-------VYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEF 183 I S+ + F+ +++LV HY + P+ + G+ + + Sbjct: 85 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY-----------MPPQALPGSTPKRAYY 133 Query: 184 YRSG 187 SG Sbjct: 134 IYSG 137 >2LAV-A nrPDB Length = 361 Score = 34.7 bits (78), Expect = 0.088, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 73/167 (43%), Gaps = 23/167 (13%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDA----TAQAFLAEASVMT 241 KE K+ IG+G FG + L D ++ VK +D T F A+ Sbjct: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 Query: 242 QLR---HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC-------L 291 Q++ + ++ LGV GL+ + ++D S + + + + Sbjct: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKV--SDFGLT 336 L+ SL + + +EY+ + +VH D+ A N+L++ N +V D+GL Sbjct: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 >4GL9-E nrPDB Length = 143 Score = 34.7 bits (78), Expect = 0.092, Method: Compositional matrix adjust. Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 7/93 (7%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 V A KL ++ +T +A LL G FL+R+S++ +TL V + ++ R Sbjct: 19 VNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLR 78 Query: 131 IMYHASKLSIDEE-------VYFENLMQLVEHY 156 I S+ + F+ +++LV HY Sbjct: 79 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 111 >2RSV-A nrPDB Length = 403 Score = 34.7 bits (78), Expect = 0.097, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 73/167 (43%), Gaps = 23/167 (13%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDA----TAQAFLAEASVMT 241 KE K+ IG+G FG + L D ++ VK +D T F A+ Sbjct: 42 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 101 Query: 242 QLR---HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC-------L 291 Q++ + ++ LGV GL+ + ++D S + + + + Sbjct: 102 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 161 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKV--SDFGLT 336 L+ SL + + +EY+ + +VH D+ A N+L++ N +V D+GL Sbjct: 162 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 208 >2CHL-A nrPDB Length = 351 Score = 34.7 bits (78), Expect = 0.097, Method: Compositional matrix adjust. Identities = 36/160 (22%), Positives = 58/160 (36%), Gaps = 9/160 (5%) Query: 199 QTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 + IG G FG++ LG Y VA+K + A E QL + + V Sbjct: 36 KKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIP--QVYY 93 Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLA 316 G Y G ++ L +L ++ + MEY+ N ++RD+ Sbjct: 94 FGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVK 153 Query: 317 ARNVLVSE-----DNVAKVSDFGLTKEASSTQDTGKLPVK 351 N L+ V + DF L KE + +P + Sbjct: 154 PENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYR 193 >2EQI-A nrPDB Length = 69 Score = 34.3 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 21/70 (30%), Positives = 34/70 (48%), Gaps = 3/70 (4%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDP-NWYKAKNKVGREGIIPANY 64 +S SG A Y++ +L FC+G + I V+K+P W+K + P+NY Sbjct: 2 SSGSSGRTVKALYDYKAKRSDELTFCRGAL--IHNVSKEPGGWWKGDYGTRIQQYFPSNY 59 Query: 65 VQKREGVKAG 74 V+ G +G Sbjct: 60 VEDISGPSSG 69 >2JII-A nrPDB Length = 352 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 19/80 (23%), Positives = 42/80 (52%), Gaps = 1/80 (1%) Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 +G V + ++V + + SL L + VL +L+ + + +A+E+L N +V Sbjct: 123 MGFGVHQDKYRFLVLPSLGR-SLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 181 Query: 312 HRDLAARNVLVSEDNVAKVS 331 H ++ A N+ V ++ ++V+ Sbjct: 182 HGNVTAENIFVDPEDQSQVT 201 >2ENM-A nrPDB Length = 77 Score = 33.9 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 17/64 (26%), Positives = 32/64 (50%), Gaps = 3/64 (4%) Query: 6 ASWPSGTECIAKYNFHGTAE---QDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPA 62 +S SG A+ + AE +L +G+++T+ W + KN G +G++P Sbjct: 2 SSGSSGMATKARVMYDFAAEPGNNELTVTEGEIITVTNPNVGGGWLEGKNNKGEQGLVPT 61 Query: 63 NYVQ 66 +YV+ Sbjct: 62 DYVE 65 >2VKN-A nrPDB Length = 70 Score = 33.5 bits (75), Expect = 0.21, Method: Composition-based stats. Identities = 15/44 (34%), Positives = 27/44 (61%), Gaps = 2/44 (4%) Query: 27 DLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREG 70 ++ F + ++L + + + W+KA+ G GIIP+NYVQ +G Sbjct: 23 EISFEQNEILQVSDI--EGRWWKARRANGETGIIPSNYVQLIDG 64 >1UGV-A nrPDB Length = 72 Score = 33.1 bits (74), Expect = 0.28, Method: Composition-based stats. Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 3/61 (4%) Query: 16 AKYNFHGTAEQD--LPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 AK + AE D L F G V V +++P W + G+ G+IP NYV+ G + Sbjct: 13 AKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLN-GKTGLIPENYVEFLSGPSS 71 Query: 74 G 74 G Sbjct: 72 G 72 >1UHF-A nrPDB Length = 69 Score = 32.7 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 5/58 (8%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVG-REGIIPANYVQKRE 69 E IA Y + DL F +G+ I+ KD W+ +G R GI P+NYV+ ++ Sbjct: 10 EYIALYPYSSVEPGDLTFTEGE--EILVTQKDGEWWTGS--IGDRSGIFPSNYVKPKD 63 >2BBU-A nrPDB Length = 164 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 7/93 (7%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 V A KL ++ +T +A LL G FL+R+S++ +TL V + ++ R Sbjct: 14 VNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLR 73 Query: 131 IMYHASKLSIDEE-------VYFENLMQLVEHY 156 I S+ + F+ +++LV HY Sbjct: 74 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 106 >5OAT-A nrPDB Length = 411 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 62/145 (42%), Gaps = 29/145 (20%) Query: 300 EAMEYLEGNNFVHRDLAARNVLVS----EDNVAKVSDFGLTKEASSTQDTGKLPVKWT-- 353 E + ++ + HRDL + N+L+ E + +SDFG T L + +T Sbjct: 164 EGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFG----CCLADKTNGLSLPYTSY 219 Query: 354 -----------APEALREKK--FS----TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396 APE + +K FS +K+D+W+ G + +EI++ Y LK+ Sbjct: 220 EMDKGGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNF- 278 Query: 397 PRVEKGYKMDAPDGCPPAVYDVMKN 421 ++G PD P + ++ N Sbjct: 279 -NYKEGDLPKLPDEVPTVIQALVAN 302 >2ED0-A nrPDB Length = 78 Score = 32.3 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 2/60 (3%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74 +A Y++ E +L F +G ++ ++ D WY+ G G+ P NYV+ G +G Sbjct: 21 VAIYDYTKDKEDELSFQEGAIIYVIK-KNDDGWYEGVMN-GVTGLFPGNYVESISGPSSG 78 >2DA9-A nrPDB Length = 70 Score = 32.3 bits (72), Expect = 0.41, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 35/70 (50%), Gaps = 2/70 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAV-TKDPNWYKAKNKVGREGIIPANY 64 +S SG C + + + +L +GD++T++ D W++ + GR G+ P N+ Sbjct: 2 SSGSSGDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELN-GRRGVFPDNF 60 Query: 65 VQKREGVKAG 74 V+ G +G Sbjct: 61 VKLLSGPSSG 70 >6HMD-A nrPDB Length = 365 Score = 32.3 bits (72), Expect = 0.44, Method: Compositional matrix adjust. Identities = 25/104 (24%), Positives = 53/104 (50%), Gaps = 6/104 (5%) Query: 289 DCLLKFSL-DVCEAMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG 346 D ++F + ++ +A++Y +HRD+ NV++ + ++ D+GL + Q+ Sbjct: 146 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN 205 Query: 347 -KLPVKW-TAPEALREKKFSTKS-DVWSFGILLWEIYSFGRVPY 387 ++ ++ PE L + + S D+WS G +L + F R P+ Sbjct: 206 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPF 248 >5XVU-A nrPDB Length = 332 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 19/83 (22%), Positives = 39/83 (46%), Gaps = 4/83 (4%) Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDN-VAKVSDFGLTKEASSTQDTGKLPVK--WTA 354 + +A++Y +HRD+ N+++ +N ++ +GL + Q+ + Sbjct: 134 ILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKG 193 Query: 355 PEALREKKFSTKS-DVWSFGILL 376 PE L + + S D+WS G +L Sbjct: 194 PELLIDLQLYDYSLDIWSLGCML 216 >1K4U-S nrPDB Length = 62 Score = 32.0 bits (71), Expect = 0.52, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 34/56 (60%), Gaps = 2/56 (3%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 G++ A +++ T +DL F +GD++ +++ + W + ++K G+ GI P +V+ Sbjct: 5 GSQVEALFSYEATQPEDLEFQEGDIILVLSKVNE-EWLEGESK-GKVGIFPKVFVE 58 >2KBT-A nrPDB Length = 142 Score = 32.0 bits (71), Expect = 0.54, Method: Compositional matrix adjust. Identities = 15/52 (28%), Positives = 28/52 (53%), Gaps = 1/52 (1%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQK 67 A+Y+F +L +GD++ I+ W++ + GR G P+NYV++ Sbjct: 10 ARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGE-IYGRIGWFPSNYVEE 60 >1I07-A nrPDB Length = 60 Score = 32.0 bits (71), Expect = 0.63, Method: Composition-based stats. Identities = 16/48 (33%), Positives = 24/48 (50%), Gaps = 2/48 (4%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPAN 63 +KY+F +L K DVL I+ + W+K +N G G +P N Sbjct: 6 SKYDFVARNSSELSVMKDDVLEILDDRR--QWWKVRNASGDSGFVPNN 51 >4WSI-A nrPDB Length = 394 Score = 31.6 bits (70), Expect = 0.72, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 4/81 (4%) Query: 28 LPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKI 87 L F KGD+L +++ +DPNW++A + + A V +E + ++SL +H Sbjct: 140 LSFQKGDILHVIS-QEDPNWWQAYREGDEDNQPLAGLVPGKEEILTYEEMSL---YHQPA 195 Query: 88 TREQAERLLYPPETGLFLVRE 108 R++ L+ P G +R+ Sbjct: 196 NRKRPIILIGPQNCGQNELRQ 216 >6EII-A nrPDB Length = 352 Score = 31.6 bits (70), Expect = 0.74, Method: Compositional matrix adjust. Identities = 23/93 (24%), Positives = 48/93 (51%), Gaps = 5/93 (5%) Query: 289 DCLLKFSL-DVCEAMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG 346 D ++F + ++ +A++Y +HRD+ NV++ E ++ D+GL + Q+ Sbjct: 153 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 212 Query: 347 -KLPVKW-TAPEALREKKFSTKS-DVWSFGILL 376 ++ ++ PE L + + S D+WS G +L Sbjct: 213 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 245 >4MD7-E nrPDB Length = 391 Score = 31.6 bits (70), Expect = 0.74, Method: Compositional matrix adjust. Identities = 23/93 (24%), Positives = 48/93 (51%), Gaps = 5/93 (5%) Query: 289 DCLLKFSL-DVCEAMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG 346 D ++F + ++ +A++Y +HRD+ NV++ E ++ D+GL + Q+ Sbjct: 130 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 189 Query: 347 -KLPVKW-TAPEALREKKFSTKS-DVWSFGILL 376 ++ ++ PE L + + S D+WS G +L Sbjct: 190 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 222 >2M0Y-A nrPDB Length = 74 Score = 31.6 bits (70), Expect = 0.76, Method: Compositional matrix adjust. Identities = 17/62 (27%), Positives = 30/62 (48%), Gaps = 4/62 (6%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN--KVGREGIIPANYVQKREGVK 72 +A YN+ +L GD + I+ + WY+ K ++GI PA+Y+ +E + Sbjct: 15 VAFYNYDARGADELSLQIGDTVHILETYE--GWYRGYTLRKKSKKGIFPASYIHLKEAIV 72 Query: 73 AG 74 G Sbjct: 73 EG 74 >2RQR-A nrPDB Length = 119 Score = 31.6 bits (70), Expect = 0.77, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 6/58 (10%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKA---KNKVGREGIIPANYVQKRE 69 +A YNF G+ L GDV+ I D WY+ K+K+ +GI P +++ +E Sbjct: 63 VAIYNFQGSGAPQLSLQIGDVVRIQETCGD--WYRGYLIKHKM-LQGIFPKSFIHIKE 117 >4NT4-A nrPDB Length = 312 Score = 31.6 bits (70), Expect = 0.82, Method: Compositional matrix adjust. Identities = 18/75 (24%), Positives = 31/75 (41%), Gaps = 13/75 (17%) Query: 290 CLLKFSL--------DVCEAMEYLEGNNFVHRDLAARNVLVS-----EDNVAKVSDFGLT 336 C KFSL + +EY+ + ++RD+ N L+ + + + DFGL Sbjct: 107 CARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLA 166 Query: 337 KEASSTQDTGKLPVK 351 KE +P + Sbjct: 167 KEYIDLDTNRHIPYR 181 >3A98-A nrPDB Length = 184 Score = 31.2 bits (69), Expect = 1.00, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 6/58 (10%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKA---KNKVGREGIIPANYVQKRE 69 +A YNF G+ L GDV+ I D WY+ K+K+ +GI P +++ +E Sbjct: 21 VAIYNFQGSGAPQLSLQIGDVVRIQETCGD--WYRGYLIKHKM-LQGIFPKSFIHIKE 75 >2V1Q-A nrPDB Length = 60 Score = 30.8 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 13/53 (24%), Positives = 29/53 (54%), Gaps = 1/53 (1%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAK-NKVGREGIIPANYVQ 66 I +Y+F ++ +L GD + I+ K +W+ + G+ G++PA +++ Sbjct: 6 IVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIE 58 >2MIO-A nrPDB Length = 70 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 15/51 (29%), Positives = 24/51 (47%), Gaps = 1/51 (1%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 A Y +L F G + V +++P W + G+ G+IP NYV+ Sbjct: 19 AVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLN-GKRGLIPQNYVK 68 >2KYM-A nrPDB Length = 120 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 29/55 (52%), Gaps = 3/55 (5%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAK--NKVGREGIIPANYVQ 66 + Y F + +L G+ L+I A D W+ AK N++G G++P +YV+ Sbjct: 6 AVTLYEFKAERDDELDVSPGENLSICA-HYDYEWFIAKPINRLGGPGLVPVSYVR 59 >2JT4-A nrPDB Length = 71 Score = 30.4 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 13/53 (24%), Positives = 29/53 (54%), Gaps = 1/53 (1%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAK-NKVGREGIIPANYVQ 66 I +Y+F ++ +L GD + I+ K +W+ + G+ G++PA +++ Sbjct: 10 IVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIE 62 >6EWX-A nrPDB Length = 484 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 11/31 (35%), Positives = 19/31 (61%) Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDN 326 L +C +E+L+ + +HRDL N+L+ N Sbjct: 217 LQLCNGLEHLKEHGIIHRDLCLENLLLVHCN 247 >1UUS-A nrPDB Length = 473 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 22/96 (22%), Positives = 43/96 (44%), Gaps = 15/96 (15%) Query: 84 HGKITREQAERLLYPPETGLFLVRESTNYPGDYTLC---VSCEGKVEHYRIMYHASKLS- 139 +G + R++ L + G F++R S PG + + V +++HY + + + + Sbjct: 355 YGYMGRQEVNDALQNQDPGTFIIRFSERNPGQFGIAYIGVEMPARIKHYLVQPNDTAAAK 414 Query: 140 ------IDEEVYFENLMQLVEHYTTDADGLCTRLIK 169 + E F NL+Q +T D +G R +K Sbjct: 415 KTFPDFLSEHSQFVNLLQ----WTKDTNG-APRFLK 445 >5VE6-A nrPDB Length = 492 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 17/74 (22%), Positives = 34/74 (45%), Gaps = 9/74 (12%) Query: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD-------CLLKFSLDVCEAMEYLEGN 308 +E+ + ++T + + D++R S C L L +C +E+L+ + Sbjct: 170 AQEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLL--LQLCNGLEHLKEH 227 Query: 309 NFVHRDLAARNVLV 322 +HRDL N+L+ Sbjct: 228 GIIHRDLCLENLLL 241 >2CUC-A nrPDB Length = 70 Score = 29.6 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 35/70 (50%), Gaps = 2/70 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANY 64 +S SG +A + + ++L KG+ + ++ +D W K + + GR GI P++Y Sbjct: 2 SSGSSGNMFVALHTYSAHRPEELDLQKGEGIRVLGKYQD-GWLKGLSLLTGRTGIFPSDY 60 Query: 65 VQKREGVKAG 74 V G +G Sbjct: 61 VIPVSGPSSG 70 >3U0O-A nrPDB Length = 347 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 1/47 (2%) Query: 58 GIIPANYVQKREGVKAGTKLSLM-PWFHGKITREQAERLLYPPETGL 103 GI+P V+K +AG KL L P G +T + + LL P GL Sbjct: 155 GIVPTERVKKNSTAQAGCKLFLTKPLGIGVLTTAEKKSLLKPEHQGL 201 >3P0L-A nrPDB Length = 221 Score = 28.5 bits (62), Expect = 5.5, Method: Compositional matrix adjust. Identities = 27/90 (30%), Positives = 40/90 (44%), Gaps = 12/90 (13%) Query: 188 WALNMKELKLLQTIGKGEFGDVML-----GDYRGNK--VAVKCIKNDATAQAFLAEASVM 240 W N+KE+K+LQ IGK F L G+ G + V+V+C K + A+ Sbjct: 84 WNPNVKEIKVLQKIGKDTFITHELAAEAAGNLVGPRDFVSVRCAKRRGSTCVLAGMAT-- 141 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMA 270 N+ + GVI E G +V +A Sbjct: 142 ---DFGNMPEQKGVIRAEHGPTCMVLHPLA 168 >4O1O-A nrPDB Length = 717 Score = 28.5 bits (62), Expect = 5.7, Method: Compositional matrix adjust. Identities = 41/185 (22%), Positives = 75/185 (40%), Gaps = 27/185 (14%) Query: 207 GDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLR-HSNLVQLLGVIVEEKGGLYIV 265 G + LG Y +VAVK +T E S + R + N+V G E G V Sbjct: 360 GGIYLGLYEDQEVAVKRFSEGSTRGQ--QEVSCLQSSRANDNVVTFYGS--ESDGSCLHV 415 Query: 266 TEYMAKGSLVDYLRS-RGRSVLG--GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV 322 + + +L ++L + RG +V + + +A+ L + + H+DL +N+L+ Sbjct: 416 CLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILI 475 Query: 323 SEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSF 382 N ++DF + +KW E K D+ + G+L+ + Sbjct: 476 DSKNGTFLADFDKS-------------IKWA------EDPQKIKRDLEALGLLVLYVVKK 516 Query: 383 GRVPY 387 G + + Sbjct: 517 GDISF 521 >4IX6-A nrPDB Length = 350 Score = 28.5 bits (62), Expect = 6.9, Method: Compositional matrix adjust. Identities = 46/172 (26%), Positives = 74/172 (43%), Gaps = 30/172 (17%) Query: 193 KELKLLQ-TIGKGEFGDVMLGDYRGNK-VAVKCIKNDATAQAFLAEASVMTQLR-HSN-- 247 K++++L +G G FG V G ++G++ V +K K D A L E + H+N Sbjct: 19 KDIRVLPGPLGSGNFGTVFRGVFKGDQDVVLKNAKADVMAAEELLECEMDVNYHVHANAK 78 Query: 248 --LVQLLGVI-VEEKGGLYIVTEYMAKG----------SLVDYLRSRGRSVLGG--DCLL 292 + +G I + K G I + +G + V+ L RG + L C Sbjct: 79 GTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACAD 138 Query: 293 KFSLDVC-EAMEYLEGN-------NFVHRDLAARNVLVSEDN--VAKVSDFG 334 L V +AM L G+ VHRD+ N++ +E + V K+ D G Sbjct: 139 ATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLG 190 >4LGM-A nrPDB Length = 295 Score = 28.5 bits (62), Expect = 7.1, Method: Compositional matrix adjust. Identities = 12/25 (48%), Positives = 16/25 (64%) Query: 133 YHASKLSIDEEVYFENLMQLVEHYT 157 Y+ SK+ +D EV E L +L E YT Sbjct: 207 YYTSKIKLDTEVSLEELAKLTEGYT 231 >2PVN-A nrPDB Length = 352 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 17/87 (19%), Positives = 39/87 (44%), Gaps = 4/87 (4%) Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSED-NVAKVSDFGLTK--EASSTQDTGKLPV 350 + ++ +A++Y +HRD+ NV++ + ++ D+GL + + Sbjct: 151 YIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASR 210 Query: 351 KWTAPEALRE-KKFSTKSDVWSFGILL 376 + PE L + + + D+WS G + Sbjct: 211 YFKGPELLVDLQDYDYSLDMWSLGCMF 237 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1K9A-A nrPDB 658 0.0 2FO0-A nrPDB 504 e-143 2H8H-A nrPDB 493 e-140 6F3F-A nrPDB 489 e-138 1AD5-A nrPDB 467 e-132 4XEY-B nrPDB 438 e-123 4XI2-A nrPDB 428 e-120 1BYG-A nrPDB 410 e-115 4E93-A nrPDB 366 e-101 4CSV-A nrPDB 339 2e-93 2PL0-A nrPDB 322 3e-88 2DQ7-X nrPDB 317 6e-87 5SYS-A nrPDB 316 1e-86 6NPU-A nrPDB 315 2e-86 2XYN-A nrPDB 315 3e-86 2HK5-A nrPDB 311 3e-85 3A4O-X nrPDB 308 4e-84 3DKO-A nrPDB 302 2e-82 4XCU-A nrPDB 302 2e-82 1JPA-A nrPDB 300 8e-82 5H2U-A nrPDB 300 1e-81 4P5Q-A nrPDB 299 2e-81 5A46-A nrPDB 297 7e-81 4EBW-A nrPDB 297 8e-81 3TT0-A nrPDB 296 1e-80 2PSQ-A nrPDB 296 1e-80 2R2P-A nrPDB 296 2e-80 3GQL-A nrPDB 294 4e-80 2J0K-A nrPDB 293 9e-80 5MJB-A nrPDB 293 1e-79 4K33-A nrPDB 292 2e-79 2OZO-A nrPDB 292 2e-79 5EG3-A nrPDB 291 4e-79 2Y6O-A nrPDB 290 8e-79 6GQK-A nrPDB 289 2e-78 4H1J-A nrPDB 288 4e-78 3SXS-A nrPDB 287 5e-78 5L6P-A nrPDB 286 2e-77 3KUL-B nrPDB 286 2e-77 2VWV-A nrPDB 285 3e-77 3CJF-A nrPDB 281 4e-76 4PDO-A nrPDB 280 7e-76 4Y93-A nrPDB 280 9e-76 4XLV-A nrPDB 279 2e-75 5AMN-A nrPDB 279 2e-75 6E4F-A nrPDB 278 4e-75 3QGY-A nrPDB 278 4e-75 3BEA-A nrPDB 278 4e-75 5KMM-A nrPDB 276 1e-74 1FVR-A nrPDB 276 1e-74 5FM2-A nrPDB 275 2e-74 2OGV-A nrPDB 275 2e-74 3G0E-A nrPDB 275 3e-74 4GS6-A nrPDB 275 3e-74 4AT3-A nrPDB 275 4e-74 3V5Q-A nrPDB 275 4e-74 1LUF-A nrPDB 274 5e-74 3KRL-A nrPDB 273 1e-73 4R7H-A nrPDB 272 2e-73 3I81-A nrPDB 271 3e-73 4XUF-A nrPDB 271 4e-73 3PPZ-A nrPDB 271 5e-73 5X02-A nrPDB 271 5e-73 5GRN-A nrPDB 271 5e-73 5U6B-A nrPDB 269 1e-72 3QUP-A nrPDB 269 1e-72 3ZBF-A nrPDB 269 2e-72 3BBT-B nrPDB 269 2e-72 3C1X-A nrPDB 268 4e-72 5HLW-A nrPDB 266 1e-71 4HZS-A nrPDB 265 2e-71 1U54-B nrPDB 265 4e-71 3PLS-A nrPDB 264 4e-71 3DTC-A nrPDB 264 4e-71 4UY9-A nrPDB 263 1e-70 3PP0-A nrPDB 263 1e-70 5VO2-A nrPDB 262 2e-70 3AOX-A nrPDB 262 3e-70 5X5O-A nrPDB 262 3e-70 4OLI-A nrPDB 261 4e-70 5U6C-A nrPDB 260 7e-70 6DBM-A nrPDB 260 1e-69 6FEX-A nrPDB 259 2e-69 5GNK-A nrPDB 258 3e-69 3LZB-A nrPDB 258 3e-69 1U59-A nrPDB 258 4e-69 6BSD-A nrPDB 258 4e-69 6DBN-A nrPDB 258 5e-69 4UYA-A nrPDB 256 1e-68 4E20-A nrPDB 255 2e-68 3COM-A nrPDB 255 3e-68 2QNJ-A nrPDB 255 3e-68 5ES1-A nrPDB 255 3e-68 2W1I-A nrPDB 255 3e-68 5KZ7-A nrPDB 255 3e-68 6FER-A nrPDB 255 3e-68 3ZZW-A nrPDB 255 4e-68 3IO7-A nrPDB 254 7e-68 4LRM-A nrPDB 253 1e-67 5JN2-A nrPDB 253 1e-67 4FL3-A nrPDB 252 2e-67 4CFF-A nrPDB 251 5e-67 4REW-A nrPDB 251 5e-67 4LG4-A nrPDB 250 1e-66 4CZT-A nrPDB 249 1e-66 5C26-A nrPDB 249 2e-66 4CFH-A nrPDB 249 2e-66 6AO5-A nrPDB 248 4e-66 5EZV-A nrPDB 247 5e-66 3MA6-A nrPDB 247 6e-66 4RED-A nrPDB 246 1e-65 3MN3-A nrPDB 245 2e-65 3NCG-A nrPDB 243 1e-64 1FOT-A nrPDB 243 1e-64 2YZA-A nrPDB 243 1e-64 3HZT-A nrPDB 243 1e-64 3DXN-A nrPDB 242 3e-64 5WNO-A nrPDB 241 4e-64 3DFA-A nrPDB 241 4e-64 4RGJ-A nrPDB 241 5e-64 3LIJ-A nrPDB 241 5e-64 3H4J-B nrPDB 241 5e-64 4QMW-A nrPDB 241 5e-64 4HVI-A nrPDB 241 6e-64 5X3F-B nrPDB 240 6e-64 4UZD-A nrPDB 240 8e-64 4D28-A nrPDB 240 8e-64 2HAK-A nrPDB 240 1e-63 4YNZ-A nrPDB 240 1e-63 4RA4-A nrPDB 239 2e-63 5HI2-A nrPDB 239 2e-63 2JC6-A nrPDB 239 2e-63 4MVF-A nrPDB 239 2e-63 4WB7-A nrPDB 238 3e-63 6C9D-A nrPDB 238 3e-63 5YKS-A nrPDB 238 4e-63 4FG9-A nrPDB 238 4e-63 5IG1-A nrPDB 237 5e-63 2JAM-A nrPDB 237 5e-63 3D2K-A nrPDB 237 8e-63 4APC-A nrPDB 237 9e-63 5HIE-A nrPDB 237 1e-62 2WQN-A nrPDB 237 1e-62 3OMV-A nrPDB 236 1e-62 3LMG-A nrPDB 236 1e-62 2XIK-A nrPDB 236 2e-62 2VN9-A nrPDB 236 2e-62 4FZF-B nrPDB 236 2e-62 5N23-A nrPDB 235 2e-62 4CQG-A nrPDB 235 2e-62 3Q5I-A nrPDB 235 2e-62 2BDW-A nrPDB 235 4e-62 3PFQ-A nrPDB 234 5e-62 2V7O-A nrPDB 234 5e-62 6FD3-A nrPDB 234 6e-62 2BPM-A nrPDB 234 7e-62 4YZB-A nrPDB 234 8e-62 4D2V-A nrPDB 233 1e-61 2UV2-A nrPDB 233 1e-61 3DAK-A nrPDB 233 2e-61 6FDY-U nrPDB 232 2e-61 5D9K-A nrPDB 232 3e-61 3KK8-A nrPDB 232 3e-61 5U6Y-A nrPDB 232 4e-61 5FG8-A nrPDB 232 4e-61 3Q53-A nrPDB 231 4e-61 3BHH-A nrPDB 231 5e-61 5DBX-A nrPDB 231 5e-61 4JXF-A nrPDB 231 6e-61 2VZ6-A nrPDB 230 7e-61 5XZW-A nrPDB 230 7e-61 4YFF-A nrPDB 230 8e-61 2Z7Q-A nrPDB 230 1e-60 2JDO-A nrPDB 229 2e-60 3HDN-A nrPDB 228 2e-60 3TXO-A nrPDB 228 4e-60 4L42-A nrPDB 228 5e-60 5KCV-A nrPDB 228 5e-60 3MV5-A nrPDB 227 6e-60 3SOA-A nrPDB 227 7e-60 4RLP-A nrPDB 227 7e-60 2I0E-A nrPDB 226 1e-59 5HVK-A nrPDB 225 3e-59 5D7A-A nrPDB 225 4e-59 5F9E-A nrPDB 224 5e-59 6HXF-B nrPDB 223 8e-59 4WNO-A nrPDB 223 1e-58 3NIZ-A nrPDB 222 3e-58 4FIE-A nrPDB 222 3e-58 2F57-A nrPDB 222 3e-58 5J5T-A nrPDB 222 3e-58 6QAU-A nrPDB 222 4e-58 3DB8-A nrPDB 221 4e-58 5JZN-A nrPDB 221 4e-58 6BDL-A nrPDB 221 4e-58 3ORZ-A nrPDB 221 5e-58 4JDH-A nrPDB 221 6e-58 2Q0N-A nrPDB 220 7e-58 3IS5-A nrPDB 220 8e-58 4NEU-A nrPDB 220 8e-58 4XBR-A nrPDB 220 1e-57 3C51-A nrPDB 220 1e-57 5LOH-A nrPDB 220 1e-57 4BBM-A nrPDB 220 1e-57 4I6B-A nrPDB 220 1e-57 5FET-A nrPDB 219 1e-57 2XNP-A nrPDB 219 2e-57 4B6L-A nrPDB 219 2e-57 4PDS-A nrPDB 219 2e-57 5DYK-A nrPDB 219 2e-57 2OU7-A nrPDB 219 2e-57 2W4O-A nrPDB 219 2e-57 4AGU-A nrPDB 218 3e-57 3F3Z-A nrPDB 217 6e-57 4F0G-A nrPDB 217 6e-57 4AF3-A nrPDB 217 6e-57 1VZO-A nrPDB 217 6e-57 4B8L-A nrPDB 217 6e-57 6CQF-A nrPDB 217 6e-57 4J52-A nrPDB 217 8e-57 6GU6-A nrPDB 217 9e-57 4NIF-A nrPDB 217 9e-57 4KS7-A nrPDB 216 1e-56 6E2O-A nrPDB 215 4e-56 5UIU-A nrPDB 215 4e-56 4JG6-A nrPDB 214 5e-56 3TAC-A nrPDB 214 6e-56 1G3N-A nrPDB 214 6e-56 4C0T-A nrPDB 214 7e-56 1CM8-A nrPDB 214 7e-56 3UC3-A nrPDB 213 8e-56 4TPT-A nrPDB 213 9e-56 3KN6-A nrPDB 213 2e-55 2J90-A nrPDB 212 2e-55 5EFQ-A nrPDB 212 3e-55 4AU8-A nrPDB 212 3e-55 3A8W-A nrPDB 212 3e-55 6CMJ-A nrPDB 211 4e-55 5TOS-A nrPDB 211 6e-55 1V0B-A nrPDB 210 7e-55 2Y7J-A nrPDB 210 8e-55 4KRC-A nrPDB 210 9e-55 2X4F-A nrPDB 210 9e-55 4NST-A nrPDB 210 1e-54 3NYO-A nrPDB 209 2e-54 2W96-B nrPDB 209 2e-54 3REP-A nrPDB 209 2e-54 4EWQ-A nrPDB 209 2e-54 1PHK-A nrPDB 208 3e-54 4U41-A nrPDB 208 5e-54 2YCR-A nrPDB 208 5e-54 1U5R-A nrPDB 208 5e-54 6E9W-A nrPDB 207 7e-54 3ALO-A nrPDB 206 1e-53 4TNB-A nrPDB 206 2e-53 5YV8-A nrPDB 206 2e-53 4EQM-A nrPDB 206 2e-53 3Q4U-A nrPDB 206 2e-53 2Y4I-B nrPDB 205 2e-53 2GCD-A nrPDB 205 2e-53 6ED6-A nrPDB 205 3e-53 2YAB-A nrPDB 205 3e-53 3HNG-A nrPDB 205 3e-53 3GUB-A nrPDB 205 4e-53 3ZDU-A nrPDB 205 4e-53 3GC9-A nrPDB 205 4e-53 3I6U-A nrPDB 204 5e-53 4OTD-A nrPDB 204 5e-53 3UTO-A nrPDB 204 6e-53 3VHK-A nrPDB 204 7e-53 3FXW-A nrPDB 204 7e-53 4AW2-A nrPDB 203 1e-52 3TKU-A nrPDB 203 1e-52 5WNL-A nrPDB 203 1e-52 4MYG-A nrPDB 203 1e-52 1UA2-A nrPDB 203 1e-52 4QTB-A nrPDB 203 1e-52 4BGQ-A nrPDB 203 1e-52 4CRS-A nrPDB 203 2e-52 3VN9-A nrPDB 203 2e-52 3OHT-A nrPDB 203 2e-52 1KOA-A nrPDB 202 3e-52 1ZWS-A nrPDB 202 3e-52 5AWM-A nrPDB 202 3e-52 2A27-A nrPDB 202 4e-52 6J5U-C nrPDB 201 5e-52 1KOB-A nrPDB 200 1e-51 4AN9-A nrPDB 200 1e-51 5NGU-A nrPDB 200 1e-51 3MDY-A nrPDB 200 1e-51 5Z33-A nrPDB 200 1e-51 2F9G-A nrPDB 200 1e-51 1NY3-A nrPDB 200 1e-51 1JNK-A nrPDB 200 1e-51 2BRG-A nrPDB 200 1e-51 6DTL-A nrPDB 200 1e-51 2XS0-A nrPDB 200 1e-51 3FME-A nrPDB 200 1e-51 2OZA-A nrPDB 199 2e-51 5LPZ-A nrPDB 199 2e-51 4FR4-A nrPDB 199 2e-51 3KA0-A nrPDB 199 2e-51 3FI2-A nrPDB 198 3e-51 3E7O-A nrPDB 198 3e-51 5LPV-A nrPDB 198 3e-51 6AMW-A nrPDB 198 4e-51 6CTH-A nrPDB 198 4e-51 3HKO-A nrPDB 198 6e-51 2BUJ-A nrPDB 197 6e-51 1PY5-A nrPDB 196 2e-50 5UUU-A nrPDB 195 2e-50 6BXI-A nrPDB 195 3e-50 3PVW-A nrPDB 195 3e-50 4IC8-A nrPDB 195 3e-50 4YHJ-A nrPDB 195 4e-50 5O2B-A nrPDB 195 4e-50 3MY0-A nrPDB 195 4e-50 2ABL-A nrPDB 195 4e-50 4PWN-A nrPDB 195 5e-50 5O2C-A nrPDB 194 6e-50 4C59-A nrPDB 193 1e-49 4O2Z-A nrPDB 193 2e-49 3LM0-A nrPDB 193 2e-49 2HW6-A nrPDB 193 2e-49 2A1A-B nrPDB 193 2e-49 3ORP-A nrPDB 192 2e-49 5Y86-A nrPDB 192 2e-49 4ZSG-A nrPDB 192 2e-49 4QNY-A nrPDB 192 3e-49 1ZXE-A nrPDB 192 3e-49 5G6V-A nrPDB 192 3e-49 3OZ6-A nrPDB 192 4e-49 5USZ-A nrPDB 192 4e-49 2VD5-A nrPDB 191 5e-49 5AIR-A nrPDB 190 8e-49 6CCF-A nrPDB 190 8e-49 5B2L-A nrPDB 190 9e-49 2WTK-C nrPDB 190 1e-48 3MIA-A nrPDB 190 1e-48 4RT7-A nrPDB 190 1e-48 3UIU-A nrPDB 189 2e-48 4MWI-A nrPDB 189 2e-48 4M7I-A nrPDB 188 5e-48 5TE0-A nrPDB 187 8e-48 4M69-B nrPDB 187 1e-47 4BTF-A nrPDB 186 2e-47 6GVJ-A nrPDB 185 3e-47 5IKW-A nrPDB 185 3e-47 6CKI-A nrPDB 185 4e-47 5KKR-C nrPDB 184 8e-47 3GC0-A nrPDB 184 8e-47 3EQC-A nrPDB 183 9e-47 3UIM-A nrPDB 183 1e-46 5ZTN-A nrPDB 183 2e-46 5AR8-A nrPDB 182 2e-46 5XD6-A nrPDB 182 3e-46 6BFN-A nrPDB 182 3e-46 3HMP-A nrPDB 182 3e-46 5O0Y-A nrPDB 181 4e-46 5TUR-A nrPDB 181 4e-46 5X8I-B nrPDB 181 6e-46 5AP3-A nrPDB 181 6e-46 3QA8-A nrPDB 181 7e-46 3BGP-A nrPDB 180 8e-46 1S9I-A nrPDB 180 9e-46 4KIK-B nrPDB 180 9e-46 2ZMD-A nrPDB 180 9e-46 2QKW-B nrPDB 180 1e-45 3DLS-A nrPDB 180 1e-45 4M66-A nrPDB 180 1e-45 4RC3-A nrPDB 179 2e-45 4X7Q-B nrPDB 178 3e-45 5TQX-A nrPDB 178 4e-45 3PG1-A nrPDB 178 5e-45 5VD3-A nrPDB 176 1e-44 2RIO-A nrPDB 176 2e-44 3E3P-A nrPDB 176 2e-44 6FYV-A nrPDB 176 2e-44 2I6L-A nrPDB 175 5e-44 3N9X-A nrPDB 174 7e-44 4Y83-A nrPDB 174 8e-44 3M42-A nrPDB 173 1e-43 4OW8-A nrPDB 173 1e-43 4X3F-A nrPDB 173 1e-43 6B2Q-A nrPDB 173 1e-43 3SOC-A nrPDB 173 2e-43 2WO6-A nrPDB 172 2e-43 1TKI-A nrPDB 172 3e-43 3EB0-A nrPDB 172 3e-43 5E8V-A nrPDB 171 7e-43 3G2F-A nrPDB 170 1e-42 4L00-A nrPDB 170 1e-42 4IDT-A nrPDB 168 5e-42 3RP9-A nrPDB 167 8e-42 1GRI-A nrPDB 167 9e-42 6HV0-A nrPDB 167 1e-41 3NIE-A nrPDB 166 1e-41 5VC6-A nrPDB 165 3e-41 4PL5-B nrPDB 165 3e-41 3RAW-A nrPDB 165 5e-41 2QLU-A nrPDB 164 6e-41 5UNP-A nrPDB 164 7e-41 5J0A-A nrPDB 163 1e-40 4G3E-A nrPDB 161 4e-40 4BTK-A nrPDB 159 2e-39 5C01-A nrPDB 158 5e-39 6O6Q-A nrPDB 158 5e-39 2WTK-B nrPDB 158 5e-39 4IAN-A nrPDB 157 8e-39 4JLC-A nrPDB 156 1e-38 4EUU-A nrPDB 156 1e-38 4NFN-A nrPDB 156 2e-38 4EUT-A nrPDB 155 3e-38 4WOV-A nrPDB 155 3e-38 4M4Z-A nrPDB 154 7e-38 6O8B-A nrPDB 154 8e-38 6NT9-A nrPDB 153 1e-37 3LLT-A nrPDB 153 1e-37 4CRL-A nrPDB 153 1e-37 4I94-A nrPDB 152 3e-37 2H34-A nrPDB 150 9e-37 4TN6-A nrPDB 148 5e-36 2PMN-X nrPDB 147 8e-36 5FQD-C nrPDB 145 6e-35 5X1R-A nrPDB 142 4e-34 3QD2-B nrPDB 139 3e-33 3T04-A nrPDB 138 5e-33 4LQP-A nrPDB 136 1e-32 4L68-A nrPDB 133 2e-31 6EAS-A nrPDB 133 2e-31 5UV4-A nrPDB 124 5e-29 5L2Q-C nrPDB 124 6e-29 1A81-A nrPDB 117 1e-26 4Y12-A nrPDB 113 2e-25 6CMQ-A nrPDB 113 2e-25 4H1O-A nrPDB 112 3e-25 5CLR-A nrPDB 109 4e-24 4XZ1-A nrPDB 106 2e-23 2B3O-A nrPDB 105 4e-23 3PS5-A nrPDB 104 6e-23 5M6U-B nrPDB 103 1e-22 1RPY-A nrPDB 103 1e-22 2EKX-A nrPDB 103 2e-22 2EOB-A nrPDB 103 2e-22 2LQW-A nrPDB 102 3e-22 2HDV-A nrPDB 101 5e-22 2VIF-A nrPDB 100 1e-21 5U06-A nrPDB 100 1e-21 2CRH-A nrPDB 99 2e-21 2AUG-A nrPDB 99 3e-21 2LCT-A nrPDB 98 5e-21 2KK6-A nrPDB 97 2e-20 1KA6-A nrPDB 96 2e-20 2PLE-A nrPDB 95 5e-20 1M27-A nrPDB 91 7e-19 1NRV-A nrPDB 91 8e-19 5GZ9-A nrPDB 91 1e-18 2EYZ-A nrPDB 91 1e-18 1MIL-A nrPDB 88 8e-18 3CXL-A nrPDB 87 1e-17 5GZA-A nrPDB 86 3e-17 1XA6-A nrPDB 85 5e-17 2CS0-A nrPDB 82 4e-16 1GBQ-A nrPDB 77 1e-14 Sequences not found previously or not previously below threshold: 5WAX-A nrPDB 219 2e-57 3ZUT-A nrPDB 210 1e-54 3UDB-A nrPDB 209 2e-54 4E7W-A nrPDB 185 3e-47 5VDK-A nrPDB 146 2e-35 3SV0-A nrPDB 138 6e-33 2JD5-A nrPDB 137 9e-33 2PVN-A nrPDB 133 2e-31 6HMD-A nrPDB 133 2e-31 4MD7-E nrPDB 132 2e-31 4WUA-A nrPDB 129 3e-30 6EII-A nrPDB 129 3e-30 4F9B-A nrPDB 128 4e-30 5XVU-A nrPDB 128 6e-30 4XHH-A nrPDB 127 9e-30 2X7G-A nrPDB 127 1e-29 5M07-A nrPDB 123 1e-28 6DC0-A nrPDB 123 2e-28 5CEK-A nrPDB 123 2e-28 2C47-A nrPDB 122 3e-28 2CHL-A nrPDB 121 5e-28 2CMW-A nrPDB 121 7e-28 4XHL-A nrPDB 118 4e-27 4LFI-A nrPDB 118 5e-27 4NT4-A nrPDB 116 3e-26 5X18-A nrPDB 115 4e-26 6J6I-B nrPDB 114 6e-26 2PZI-A nrPDB 113 2e-25 1CSN-A nrPDB 112 4e-25 5OAT-A nrPDB 112 4e-25 6EQI-C nrPDB 111 7e-25 4JRN-A nrPDB 91 1e-18 5NP2-A nrPDB 78 6e-15 2RSV-A nrPDB 78 1e-14 2LAV-A nrPDB 77 2e-14 4O1O-A nrPDB 76 3e-14 >1K9A-A nrPDB Length = 450 Score = 658 bits (1699), Expect = 0.0, Method: Composition-based stats. Identities = 450/450 (100%), Positives = 450/450 (100%) Query: 1 MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII 60 MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII Sbjct: 1 MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII 60 Query: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV Sbjct: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120 Query: 121 SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQ 180 SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQ Sbjct: 121 SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQ 180 Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM 240 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM Sbjct: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM 240 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE 360 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE Sbjct: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE 360 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK Sbjct: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 Query: 421 NCWHLDAATRPTFLQLREQLEHIRTHELHL 450 NCWHLDAATRPTFLQLREQLEHIRTHELHL Sbjct: 421 NCWHLDAATRPTFLQLREQLEHIRTHELHL 450 >2FO0-A nrPDB Length = 495 Score = 504 bits (1299), Expect = e-143, Method: Composition-based stats. Identities = 174/442 (39%), Positives = 253/442 (57%), Gaps = 19/442 (4%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 +A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ Sbjct: 43 FVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITPVNS--- 98 Query: 74 GTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY 133 L W+HG ++R AE LL G FLVRES + PG ++ + EG+V HYRI Sbjct: 99 ---LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINT 155 Query: 134 -HASKLSIDEEVYFENLMQLVEHYTTDADGLCT--RLIKPKVMEGTVAAQDEFYRSGWAL 190 KL + E F L +LV H++T ADGL T PK + TV Y W + Sbjct: 156 ASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY-DKWEM 214 Query: 191 NMKELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCIKNDATA-QAFLAEASVMTQLRHSN 247 ++ + +G G++G+V G ++ VAVK +K D + FL EA+VM +++H N Sbjct: 215 ERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 274 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 LVQLLGV E YI+TE+M G+L+DYLR R + LL + + AMEYLE Sbjct: 275 LVQLLGVCTREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK 333 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKF 363 NF+HR+LAARN LV E+++ KV+DFGL++ + T K P+KWTAPE+L KF Sbjct: 334 KNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKF 393 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 S KSDVW+FG+LLWEI ++G PYP I L V +EK Y+M+ P+GCP VY++M+ CW Sbjct: 394 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW 453 Query: 424 HLDAATRPTFLQLREQLEHIRT 445 + + RP+F ++ + E + Sbjct: 454 QWNPSDRPSFAEIHQAFETMFQ 475 >2H8H-A nrPDB Length = 535 Score = 493 bits (1270), Expect = e-140, Method: Composition-based stats. Identities = 181/448 (40%), Positives = 250/448 (55%), Gaps = 24/448 (5%) Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71 T +A Y++ E DL F KG+ L IV T+ W G+ G IP+NYV + + Sbjct: 86 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 145 Query: 72 KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS-----CEG 124 +A W+ GKITR ++ERLL E G FLVRES G Y L VS Sbjct: 146 QAE------EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 199 Query: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEF 183 V+HY+I + I F +L QLV +Y+ ADGLC RL V + Sbjct: 200 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPTSKPQTQGL 257 Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMT 241 + W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM Sbjct: 258 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 317 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + + Sbjct: 318 KLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 375 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357 M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA Sbjct: 376 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 435 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++D Sbjct: 436 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 495 Query: 418 VMKNCWHLDAATRPTFLQLREQLEHIRT 445 +M CW + RPTF L+ LE T Sbjct: 496 LMCQCWRKEPEERPTFEYLQAFLEDYFT 523 >6F3F-A nrPDB Length = 455 Score = 489 bits (1259), Expect = e-138, Method: Composition-based stats. Identities = 182/448 (40%), Positives = 249/448 (55%), Gaps = 24/448 (5%) Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71 T +A Y++ E DL F KG+ L IV T+ W G+ G IP+NYV + + Sbjct: 6 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 65 Query: 72 KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS-----CEG 124 +A W+ GKITR ++ERLL E G FLVRES G Y L VS Sbjct: 66 QAE------EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 119 Query: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEF 183 V+HY+I + I F +L QLV +Y+ ADGLC RL V + Sbjct: 120 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPTSKPQTQGL 177 Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMT 241 + W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM Sbjct: 178 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 237 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +LRH LVQL V+ EE +YIVTEYM KGSL+D+L+ L L+ S + Sbjct: 238 KLRHEKLVQLYAVVSEEP--IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASG 295 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357 M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA Sbjct: 296 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 355 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++D Sbjct: 356 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 415 Query: 418 VMKNCWHLDAATRPTFLQLREQLEHIRT 445 +M CW + RPTF L+ LE T Sbjct: 416 LMCQCWRKEPEERPTFEYLQAFLEDYFT 443 >1AD5-A nrPDB Length = 438 Score = 467 bits (1201), Expect = e-132, Method: Composition-based stats. Identities = 168/443 (37%), Positives = 249/443 (56%), Gaps = 30/443 (6%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKREGVK 72 +A Y++ +DL F KGD + ++ + W+KA++ R EG IP+NYV + + Sbjct: 5 VVALYDYEAIHHEDLSFQKGDQMVVLEES--GEWWKARSLATRKEGYIPSNYVARVDS-- 60 Query: 73 AGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS-----CEGK 125 L WF I+R+ AER L P G F++R+S G Y+L V Sbjct: 61 ----LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDT 116 Query: 126 VEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFY 184 V+HY+I I F L +LV+HY DGLC +L P + + Q + Sbjct: 117 VKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM---SSKPQKPWE 173 Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIKNDATA-QAFLAEASVMTQ 242 + W + + LKL + +G G+FG+V + Y + KVAVK +K + + +AFLAEA+VM Sbjct: 174 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 233 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L+H LV+L V+ +E +YI+TE+MAKGSL+D+L+S S L+ FS + E M Sbjct: 234 LQHDKLVKLHAVVTKEP--IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGM 291 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKK 362 ++E N++HRDL A N+LVS V K++DFGL + K P+KWTAPEA+ Sbjct: 292 AFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVG------AKFPIKWTAPEAINFGS 345 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 F+ KSDVWSFGILL EI ++GR+PYP + +V+ +E+GY+M P+ CP +Y++M C Sbjct: 346 FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRC 405 Query: 423 WHLDAATRPTFLQLREQLEHIRT 445 W RPTF ++ L+ T Sbjct: 406 WKNRPEERPTFEYIQSVLDDFYT 428 >4XEY-B nrPDB Length = 408 Score = 438 bits (1126), Expect = e-123, Method: Composition-based stats. Identities = 160/385 (41%), Positives = 226/385 (58%), Gaps = 12/385 (3%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 + + L W+HG ++R AE LL G FLVRES + PG ++ + EG+V HYR Sbjct: 1 MASVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYR 60 Query: 131 IMY-HASKLSIDEEVYFENLMQLVEHYTTDADGLCT--RLIKPKVMEGTVAAQDEFYRSG 187 I KL + E F L +LV H++T ADGL T PK + TV Y Sbjct: 61 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY-DK 119 Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCIKNDATA-QAFLAEASVMTQLR 244 W + ++ + +G G++G+V G ++ VAVK +K D + FL EA+VM +++ Sbjct: 120 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 179 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H NLVQLLGV E YI+TE+M G+L+DYLR R + LL + + AMEY Sbjct: 180 HPNLVQLLGVCTREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 238 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALRE 360 LE NF+HRDLAARN LV E+++ KV+DFGL++ + T K P+KWTAPE+L Sbjct: 239 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 298 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 KFS KSDVW+FG+LLWEI ++G PYP I L V +EK Y+M+ P+GCP VY++M+ Sbjct: 299 NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 358 Query: 421 NCWHLDAATRPTFLQLREQLEHIRT 445 CW + + RP+F ++ + E + Sbjct: 359 ACWQWNPSDRPSFAEIHQAFETMFQ 383 >4XI2-A nrPDB Length = 446 Score = 428 bits (1102), Expect = e-120, Method: Composition-based stats. Identities = 162/442 (36%), Positives = 246/442 (55%), Gaps = 24/442 (5%) Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71 + +A Y++ DL KG+ I+ + P W++A++K G+EG IP+NY+ Sbjct: 4 KKVVALYDYMPMNANDLQLRKGEEYFILEESNLP-WWRARDKNGQEGYIPSNYIT----- 57 Query: 72 KAGTKLSLMPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSC------EG 124 +A + + W+ +TR QAE+LL G F+VR+S + G YT+ V +G Sbjct: 58 EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGEPQG 116 Query: 125 KVEHYRIMYH-ASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEF 183 + HY + S+ + E+ F + +L+ ++ ++ GL +RL P + A Sbjct: 117 VIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAG 176 Query: 184 YRSG-WALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVM 240 G W ++ K+L L+ +G G+FG V G +RG VA+K I+ + ++ F+ EA VM Sbjct: 177 LGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVM 236 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 L H LVQL GV +++ ++I+TEYMA G L++YLR R LL+ DVCE Sbjct: 237 MNLSHEKLVQLYGVCTKQRP-IFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCE 294 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPE 356 AMEYLE F+HRDLAARN LV++ V KVSDFGL++ + T K PV+W+ PE Sbjct: 295 AMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPE 354 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY 416 L KFS+KSD+W+FG+L+WEIYS G++PY R + + +G ++ P VY Sbjct: 355 VLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVY 414 Query: 417 DVMKNCWHLDAATRPTFLQLRE 438 +M +CWH A RP+F L Sbjct: 415 TIMYSCWHEKADERPSFKILLS 436 >1BYG-A nrPDB Length = 278 Score = 410 bits (1054), Expect = e-115, Method: Composition-based stats. Identities = 272/278 (97%), Positives = 276/278 (99%) Query: 173 MEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQA 232 M G+VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQA Sbjct: 1 MGGSVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQA 60 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL Sbjct: 61 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 120 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW 352 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW Sbjct: 121 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW 180 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP Sbjct: 181 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 240 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL 450 PAVY+VMKNCWHLDAA RP+FLQLREQLEHI+THELHL Sbjct: 241 PAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL 278 >4E93-A nrPDB Length = 377 Score = 366 bits (939), Expect = e-101, Method: Composition-based stats. Identities = 139/385 (36%), Positives = 201/385 (52%), Gaps = 24/385 (6%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 + L W+HG I R + LL +G FLVRES +Y L V +G H+ Sbjct: 4 PEVQKPLHEQLWYHGAIPRAEVAELLV--HSGDFLVRESQG-KQEYVLSVLWDGLPRHFI 60 Query: 131 IMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWAL 190 I L E F ++ L++H + +P + V + W L Sbjct: 61 I-QSLDNLYRLEGEGFPSIPLLIDHLLSTQ--------QPLTKKSGVVLHRAVPKDKWVL 111 Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ---AFLAEASVMTQLRH 245 N ++L L + IG+G FG+V G R VAVK + FL EA ++ Q H Sbjct: 112 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSH 171 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+V+L+GV + K +YIV E + G + +LR+ G + L LL+ D MEYL Sbjct: 172 PNIVRLIGVCTQ-KQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAAAGMEYL 229 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-----KLPVKWTAPEALRE 360 E +HRDLAARN LV+E NV K+SDFG+++E + ++PVKWTAPEAL Sbjct: 230 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 289 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 ++S++SDVWSFGILLWE +S G PYP + + VEKG ++ P+ CP AV+ +M+ Sbjct: 290 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 349 Query: 421 NCWHLDAATRPTFLQLREQLEHIRT 445 CW + RP+F + ++L+ IR Sbjct: 350 QCWAYEPGQRPSFSTIYQELQSIRK 374 >4CSV-A nrPDB Length = 275 Score = 339 bits (870), Expect = 2e-93, Method: Composition-based stats. Identities = 122/269 (45%), Positives = 169/269 (62%), Gaps = 8/269 (2%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCIKNDATA-QAFLAEASVMTQ 242 W + E+ L + +G G+FG+V G +R +VAVK +K + + FL EA +M + Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKK 63 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L+H NLVQL GV +E +YI+TEYM+ GSL+DYLR + LL + V M Sbjct: 64 LKHPNLVQLYGVCTKEPP-IYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGM 122 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEAL 358 YLE NF+HRDLAARN LV E+NV KV+DFGL + + + T K P+KWTAPEA+ Sbjct: 123 AYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAI 182 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 +FS KSDVW+FGILLWEI+++G+VPYP + +V+ +VE+GY+M P GCP +Y++ Sbjct: 183 SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYEL 242 Query: 419 MKNCWHLDAATRPTFLQLREQLEHIRTHE 447 M CW+ RPTF + LE + E Sbjct: 243 MLQCWNKSPEERPTFAETLHALETMFLPE 271 >2PL0-A nrPDB Length = 289 Score = 322 bits (825), Expect = 3e-88, Method: Composition-based stats. Identities = 119/276 (43%), Positives = 171/276 (61%), Gaps = 8/276 (2%) Query: 176 TVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAF 233 T Q ++ W + + LKL++ +G G+FG+V +G Y G+ KVAVK +K + + AF Sbjct: 6 TQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAF 65 Query: 234 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 293 LAEA++M QL+H LV+L V+ +E +YI+TEYM GSLVD+L++ L + LL Sbjct: 66 LAEANLMKQLQHQRLVRLYAVVTQEP--IYIITEYMENGSLVDFLKTPSGIKLTINKLLD 123 Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLP 349 + + E M ++E N++HRDL A N+LVS+ K++DFGL + + T K P Sbjct: 124 MAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP 183 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD 409 +KWTAPEA+ F+ KSDVWSFGILL EI + GR+PYP + +V+ +E+GY+M PD Sbjct: 184 IKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPD 243 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 CP +Y +M+ CW RPTF LR LE T Sbjct: 244 NCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFT 279 >2DQ7-X nrPDB Length = 283 Score = 317 bits (813), Expect = 6e-87, Method: Composition-based stats. Identities = 111/267 (41%), Positives = 166/267 (62%), Gaps = 8/267 (2%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-NKVAVKCIKNDATA-QAFLAEASVMTQ 242 + W + + L+L++ +G G+FG+V +G + G KVA+K +K + ++FL EA +M + Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK 60 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L+H LVQL V+ EE +YIVTEYM KGSL+D+L+ L L+ + V M Sbjct: 61 LKHDKLVQLYAVVSEEP--IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGM 118 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEAL 358 Y+E N++HRDL + N+LV + K++DFGL + + T K P+KWTAPEA Sbjct: 119 AYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 178 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++++ Sbjct: 179 LYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHEL 238 Query: 419 MKNCWHLDAATRPTFLQLREQLEHIRT 445 M +CW D RPTF L+ LE T Sbjct: 239 MIHCWKKDPEERPTFEYLQSFLEDYFT 265 >5SYS-A nrPDB Length = 286 Score = 316 bits (810), Expect = 1e-86, Method: Composition-based stats. Identities = 117/271 (43%), Positives = 165/271 (60%), Gaps = 8/271 (2%) Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEAS 238 + W + + L+L +G+G FG+ +G + G +VA+K +K + +AFL EA Sbjct: 6 QGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQ 65 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 VM +LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + + Sbjct: 66 VMKKLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQI 123 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTA 354 M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTA Sbjct: 124 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 183 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414 PEA +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP + Sbjct: 184 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 243 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 ++D+M CW D RPTF L+ LE T Sbjct: 244 LHDLMCQCWRKDPEERPTFEYLQAFLEDYFT 274 >6NPU-A nrPDB Length = 298 Score = 315 bits (808), Expect = 2e-86, Method: Composition-based stats. Identities = 116/267 (43%), Positives = 167/267 (62%), Gaps = 8/267 (2%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCIKNDATA-QAFLAEASVMTQ 242 W + ++ + +G G++G+V G ++ VAVK +K D + FL EA+VM + Sbjct: 19 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 78 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 ++H NLVQLLGV E YI+TE+M G+L+DYLR R + LL + + AM Sbjct: 79 IKHPNLVQLLGVCTREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 137 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEAL 358 EYLE NF+HRDLAARN LV E+++ KV+DFGL++ + T K P+KWTAPE+L Sbjct: 138 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 197 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 KFS KSDVW+FG+LLWEI ++G PYP I L V +EK Y+M+ P+GCP VY++ Sbjct: 198 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYEL 257 Query: 419 MKNCWHLDAATRPTFLQLREQLEHIRT 445 M+ CW + + RP+F ++ + E + Sbjct: 258 MRACWQWNPSDRPSFAEIHQAFETMFQ 284 >2XYN-A nrPDB Length = 292 Score = 315 bits (807), Expect = 3e-86, Method: Composition-based stats. Identities = 121/266 (45%), Positives = 167/266 (62%), Gaps = 8/266 (3%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCIKNDATA-QAFLAEASVMTQ 242 W + ++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM + Sbjct: 25 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 84 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 ++H NLVQLLGV E YIVTEYM G+L+DYLR R + LL + + AM Sbjct: 85 IKHPNLVQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 143 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEAL 358 EYLE NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L Sbjct: 144 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 203 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 FS KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VY++ Sbjct: 204 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 263 Query: 419 MKNCWHLDAATRPTFLQLREQLEHIR 444 M+ CW A RP+F + + E + Sbjct: 264 MRACWKWSPADRPSFAETHQAFETMF 289 >2HK5-A nrPDB Length = 270 Score = 311 bits (798), Expect = 3e-85, Method: Composition-based stats. Identities = 115/272 (42%), Positives = 170/272 (62%), Gaps = 8/272 (2%) Query: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIKNDATA-QAFLAE 236 AQ + + W + + LKL + +G G+FG+V + Y + KVAVK +K + + +AFLAE Sbjct: 1 AQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAE 60 Query: 237 ASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296 A+VM L+H LV+L V+ +E +YI+TE+MAKGSL+D+L+S S L+ FS Sbjct: 61 ANVMKTLQHDKLVKLHAVVTKEP--IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSA 118 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKW 352 + E M ++E N++HRDL A N+LVS V K++DFGL + + T K P+KW Sbjct: 119 QIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKW 178 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 TAPEA+ F+ KSDVWSFGILL EI ++GR+PYP + +V+ +E+GY+M P+ CP Sbjct: 179 TAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP 238 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 +Y++M CW RPTF ++ L+ Sbjct: 239 EELYNIMMRCWKNRPEERPTFEYIQSVLDDFE 270 >3A4O-X nrPDB Length = 286 Score = 308 bits (789), Expect = 4e-84, Method: Composition-based stats. Identities = 117/271 (43%), Positives = 169/271 (62%), Gaps = 7/271 (2%) Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-NKVAVKCIKNDATA-QAFLAEAS 238 + + W + + +KL++ +G G+FG+V +G Y KVAVK +K + QAFL EA+ Sbjct: 1 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEAN 60 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 +M L+H LV+L V+ E+ +YI+TEYMAKGSL+D+L+S + L+ FS + Sbjct: 61 LMKTLQHDKLVRLYAVVTREEP-IYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQI 119 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTA 354 E M Y+E N++HRDL A NVLVSE + K++DFGL + + T K P+KWTA Sbjct: 120 AEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 179 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414 PEA+ F+ KSDVWSFGILL+EI ++G++PYP DV+ + +GY+M + CP Sbjct: 180 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 239 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 +YD+MK CW A RPTF L+ L+ T Sbjct: 240 LYDIMKMCWKEKAEERPTFDYLQSVLDDFYT 270 >3DKO-A nrPDB Length = 318 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 117/317 (36%), Positives = 175/317 (55%), Gaps = 30/317 (9%) Query: 141 DEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQT 200 DEE+YF + Y I P+ E A +F + L+ +K+ + Sbjct: 5 DEELYFHFKFPGTKTY-----------IDPETYEDPNRAVHQFAK---ELDASCIKIERV 50 Query: 201 IGKGEFGDVMLGDYR--GNK---VAVKCIK---NDATAQAFLAEASVMTQLRHSNLVQLL 252 IG GEFG+V G + G + VA+K +K + + FL EAS+M Q H N+V L Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 110 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 GV+ K + IV E+M G+L +LR L+ + M YL +VH Sbjct: 111 GVVTRGKP-VMIVIEFMENGALDAFLRKHDGQ-FTVIQLVGMLRGIAAGMRYLADMGYVH 168 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKWTAPEALREKKFSTK 366 RDLAARN+LV+ + V KVSDFGL++ EA T GK+PV+WTAPEA++ +KF++ Sbjct: 169 RDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSA 228 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 SDVWS+GI++WE+ S+G PY + +DV+ +E+GY++ AP CP ++ +M +CW + Sbjct: 229 SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKE 288 Query: 427 AATRPTFLQLREQLEHI 443 A RP F Q+ L+ + Sbjct: 289 RAERPKFEQIVGILDKM 305 >4XCU-A nrPDB Length = 300 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 114/279 (40%), Positives = 167/279 (59%), Gaps = 24/279 (8%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGN---------KVAVKCIKNDATAQAF---LA 235 W L L + +G+G FG V+ + G VAVK +K++A+ + ++ Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 71 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS-----VLGGD 289 E VM + RH N++ LLGV +E G LY++ E AKG+L ++LR+R L Sbjct: 72 EMEVMKLIGRHKNIINLLGVCTQE-GPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFP 130 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQD 344 L+ + V M+YLE +HRDLAARNVLV+EDNV K++DFGL + + Sbjct: 131 VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS 190 Query: 345 TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404 G+LPVKW APEAL ++ ++ +SDVWSFGILLWEI++ G PYP IP++++ + +G++ Sbjct: 191 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHR 250 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 MD P CPP +Y +M+ CWH + RPTF QL E L+ + Sbjct: 251 MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 289 >1JPA-A nrPDB Length = 312 Score = 300 bits (769), Expect = 8e-82, Method: Composition-based stats. Identities = 107/293 (36%), Positives = 168/293 (57%), Gaps = 21/293 (7%) Query: 167 LIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAV 221 I P E A EF + +++ +K+ Q IG GEFG+V G + G + VA+ Sbjct: 10 FIDPFTFEDPNEAVREFAK---EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAI 66 Query: 222 KCIKN---DATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL 278 K +K+ + + FL+EAS+M Q H N++ L GV+ + + I+TE+M GSL +L Sbjct: 67 KTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKS-TPVMIITEFMENGSLDSFL 125 Query: 279 RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 R + L+ + M+YL N+VHRDLAARN+LV+ + V KVSDFGL++ Sbjct: 126 R-QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRF 184 Query: 339 ASSTQDT--------GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI 390 GK+P++WTAPEA++ +KF++ SDVWS+GI++WE+ S+G PY + Sbjct: 185 LEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDM 244 Query: 391 PLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +DV+ +E+ Y++ P CP A++ +M +CW D RP F Q+ L+ + Sbjct: 245 TNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 297 >5H2U-A nrPDB Length = 267 Score = 300 bits (768), Expect = 1e-81, Method: Composition-based stats. Identities = 114/268 (42%), Positives = 153/268 (57%), Gaps = 7/268 (2%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDA--TAQAFLAEASVMTQLR 244 +E L + +G G FG+V G ++ +VA+K I D Q +E M +LR Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR 60 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H +++ L V+ +YI+TE MAKGSL++ LR VL LL + V E M Y Sbjct: 61 HKHILALYAVV-SVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCY 119 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAPEALREK 361 LE N++HRDLAARN+LV E+ + KV DFGL + +P KWTAPEAL Sbjct: 120 LESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRG 179 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 +STKSDVWSFGILL E++S G+VPYP + + RV+ GY+M P CPP+V+ +M Sbjct: 180 HYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLT 239 Query: 422 CWHLDAATRPTFLQLREQLEHIRTHELH 449 CW D RPTF LRE+L +H H Sbjct: 240 CWCRDPEQRPTFKALRERLSSFTSHHHH 267 >4P5Q-A nrPDB Length = 361 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 108/286 (37%), Positives = 165/286 (57%), Gaps = 19/286 (6%) Query: 172 VMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR-----GNKVAVKCIK- 225 V G+ EF + L+ + + + +G GEFG+V G + VA+K +K Sbjct: 15 VPRGSTQTVHEFAK---ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKV 71 Query: 226 --NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR 283 + + FL EAS+M Q H N+++L GV+ + K + IVTEYM GSL +LR Sbjct: 72 GYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKP-VMIVTEYMENGSLDSFLRKHDA 130 Query: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------ 337 L+ + M+YL +VHRDLAARN+L++ + V KVSDFGL++ Sbjct: 131 Q-FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDP 189 Query: 338 EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVP 397 EA+ T GK+P++WT+PEA+ +KF++ SDVWS+GI+LWE+ S+G PY + +DV+ Sbjct: 190 EAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIK 249 Query: 398 RVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 V++GY++ P CP A+Y +M +CW D RP F Q+ L+ + Sbjct: 250 AVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKL 295 >5A46-A nrPDB Length = 386 Score = 297 bits (760), Expect = 7e-81, Method: Composition-based stats. Identities = 112/288 (38%), Positives = 169/288 (58%), Gaps = 33/288 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRG---------NKVAVKCIKNDATAQAF---LA 235 W L L L + +G+G FG V+L + G KVAVK +K+DAT + ++ Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 94 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR------------- 281 E +M + +H N++ LLG ++ G LY++ EY +KG+L +YL++R Sbjct: 95 EMEMMKMIGKHKNIINLLGACTQD-GPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSH 153 Query: 282 -GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA- 339 L L+ + V MEYL +HRDLAARNVLV+EDNV K++DFGL ++ Sbjct: 154 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 213 Query: 340 ----SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 G+LPVKW APEAL ++ ++ +SDVWSFG+LLWEI++ G PYP +P++++ Sbjct: 214 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL 273 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +++G++MD P C +Y +M++CWH + RPTF QL E L+ I Sbjct: 274 FKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 321 >4EBW-A nrPDB Length = 304 Score = 297 bits (760), Expect = 8e-81, Method: Composition-based stats. Identities = 103/273 (37%), Positives = 156/273 (57%), Gaps = 15/273 (5%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK-----VAVKCIKN---DATAQAFLAEASV 239 + + + ++L + IG+G+FGDV G Y + VA+K KN D+ + FL EA Sbjct: 33 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT 92 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 M Q H ++V+L+GVI E ++I+ E G L +L+ R S L L+ ++ + Sbjct: 93 MRQFDHPHIVKLIGVITE--NPVWIIMELCTLGELRSFLQVRKYS-LDLASLILYAYQLS 149 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAP 355 A+ YLE FVHRD+AARNVLVS ++ K+ DFGL++ + GKLP+KW AP Sbjct: 150 TALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAP 209 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ ++F++ SDVW FG+ +WEI G P+ + DV+ R+E G ++ P CPP + Sbjct: 210 ESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTL 269 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHIRTHEL 448 Y +M CW D + RP F +L+ QL I E Sbjct: 270 YSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK 302 >3TT0-A nrPDB Length = 382 Score = 296 bits (759), Expect = 1e-80, Method: Composition-based stats. Identities = 115/306 (37%), Positives = 175/306 (57%), Gaps = 36/306 (11%) Query: 173 MEGTVAAQDEFY---RSGWALNMKELKLLQTIGKGEFGDVMLGDYRG---------NKVA 220 +G +A E+ W L L L + +G+G FG V+L + G KVA Sbjct: 46 FQGMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVA 105 Query: 221 VKCIKNDATAQAF---LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD 276 VK +K+DAT + ++E +M + +H N++ LLG ++ G LY++ EY +KG+L + Sbjct: 106 VKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQD-GPLYVIVEYASKGNLRE 164 Query: 277 YLRSR--------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV 322 YL++R L L+ + V MEYL +HRDLAARNVLV Sbjct: 165 YLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV 224 Query: 323 SEDNVAKVSDFGLTKEA-----SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLW 377 +EDNV K++DFGL ++ G+LPVKW APEAL ++ ++ +SDVWSFG+LLW Sbjct: 225 TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLW 284 Query: 378 EIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLR 437 EI++ G PYP +P++++ +++G++MD P C +Y +M++CWH + RPTF QL Sbjct: 285 EIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLV 344 Query: 438 EQLEHI 443 E L+ I Sbjct: 345 EDLDRI 350 >2PSQ-A nrPDB Length = 370 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 108/291 (37%), Positives = 170/291 (58%), Gaps = 33/291 (11%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGN---------KVAVKCIKNDATAQAF---L 234 W +L L + +G+G FG V++ + G VAVK +K+DAT + + Sbjct: 75 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 134 Query: 235 AEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVL------- 286 +E +M + +H N++ LLG ++ G LY++ EY +KG+L +YLR+R + Sbjct: 135 SEMEMMKMIGKHKNIINLLGACTQD-GPLYVIVEYASKGNLREYLRARRPPGMEYSYDIN 193 Query: 287 --GGDC-----LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA 339 + L+ + + MEYL +HRDLAARNVLV+E+NV K++DFGL ++ Sbjct: 194 RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 253 Query: 340 -----SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD 394 G+LPVKW APEAL ++ ++ +SDVWSFG+L+WEI++ G PYP IP+++ Sbjct: 254 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEE 313 Query: 395 VVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 + +++G++MD P C +Y +M++CWH + RPTF QL E L+ I T Sbjct: 314 LFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 364 >2R2P-A nrPDB Length = 295 Score = 296 bits (758), Expect = 2e-80, Method: Composition-based stats. Identities = 108/288 (37%), Positives = 168/288 (58%), Gaps = 19/288 (6%) Query: 170 PKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCI 224 P E A EF + + + + + IG GEFG+V G + G + VA+K + Sbjct: 2 PHTYEDPNQAVHEFAK---EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTL 58 Query: 225 K---NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR 281 K + + FL EAS+M Q H N++ L GV+ + K + IVTEYM GSL +L+ + Sbjct: 59 KVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKP-VMIVTEYMENGSLDTFLK-K 116 Query: 282 GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK---- 337 L+ + M+YL +VHRDLAARN+L++ + V KVSDFGL++ Sbjct: 117 NDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLED 176 Query: 338 --EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 EA+ T GK+P++WTAPEA+ +KF++ SDVWS+GI++WE+ S+G PY + +DV Sbjct: 177 DPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDV 236 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + VE+GY++ +P CP A+Y +M +CW + +RP F ++ L+ + Sbjct: 237 IKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKL 284 >3GQL-A nrPDB Length = 326 Score = 294 bits (754), Expect = 4e-80, Method: Composition-based stats. Identities = 112/288 (38%), Positives = 169/288 (58%), Gaps = 33/288 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRG---------NKVAVKCIKNDATAQAF---LA 235 W L L L + +G+G FG V+L + G KVAVK +K+DAT + ++ Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 82 Query: 236 EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR------------- 281 E +M + +H N++ LLG ++ G LY++ EY +KG+L +YL++R Sbjct: 83 EMEMMKMIGKHKNIINLLGACTQD-GPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSH 141 Query: 282 -GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA- 339 L L+ + V MEYL +HRDLAARNVLV+EDNV K++DFGL ++ Sbjct: 142 NPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH 201 Query: 340 ----SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 G+LPVKW APEAL ++ ++ +SDVWSFG+LLWEI++ G PYP +P++++ Sbjct: 202 HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL 261 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +++G++MD P C +Y +M++CWH + RPTF QL E L+ I Sbjct: 262 FKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 309 >2J0K-A nrPDB Length = 656 Score = 293 bits (751), Expect = 9e-80, Method: Composition-based stats. Identities = 103/273 (37%), Positives = 154/273 (56%), Gaps = 15/273 (5%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYR-----GNKVAVKCIKN---DATAQAFLAEASV 239 + + + ++L + IG+G+FGDV G Y VA+K KN D+ + FL EA Sbjct: 385 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALT 444 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 M Q H ++V+L+GVI E ++I+ E G L +L+ R S L L+ ++ + Sbjct: 445 MRQFDHPHIVKLIGVITE--NPVWIIMELCTLGELRSFLQVRKFS-LDLASLILYAYQLS 501 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAP 355 A+ YLE FVHRD+AARNVLVS + K+ DFGL++ + GKLP+KW AP Sbjct: 502 TALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAP 561 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ ++F++ SDVW FG+ +WEI G P+ + DV+ R+E G ++ P CPP + Sbjct: 562 ESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTL 621 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHIRTHEL 448 Y +M CW D + RP F +L+ QL I E Sbjct: 622 YSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK 654 >5MJB-A nrPDB Length = 305 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 102/287 (35%), Positives = 166/287 (57%), Gaps = 21/287 (7%) Query: 173 MEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCIK-- 225 A EF + +++ +K+ + IG GEFG+V G + G + VA+K +K Sbjct: 9 GSDPNEAVREFAK---EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAG 65 Query: 226 -NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS 284 ++ + FL+EAS+M Q H N+++L GV+ + + + I+TE+M +L +LR + Sbjct: 66 YSEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRP-VMIITEFMENCALDSFLR-QNDG 123 Query: 285 VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD 344 L+ + M+YL N+VHRDLAARN+LV+ + V KVSDFGL++ Sbjct: 124 QFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTS 183 Query: 345 T--------GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396 GK+PV+WTAPEA+ +KF++ SDVWS+GI++WE+ SFG PY + +DV+ Sbjct: 184 DPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVI 243 Query: 397 PRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +E+ Y++ P CP A++ +M +CW D +RP F ++ L+ + Sbjct: 244 NAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKM 290 >4K33-A nrPDB Length = 325 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 112/291 (38%), Positives = 168/291 (57%), Gaps = 33/291 (11%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGN---------KVAVKCIKNDATAQAF---L 234 W L+ L L + +G+G FG V++ + G VAVK +K+DAT + + Sbjct: 30 KWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLV 89 Query: 235 AEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD---- 289 +E +M + +H N++ LLG + G LY++ EY AKG+L ++LR+R L Sbjct: 90 SEMEMMKMIGKHKNIINLLGACTQ-GGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTS 148 Query: 290 ----------CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE- 338 L+ + V MEYL +HRDLAARNVLV+EDNV K++DFGL ++ Sbjct: 149 KPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV 208 Query: 339 ----ASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD 394 G+LPVKW APEAL ++ ++ +SDVWSFG+LLWEI++ G PYP IP+++ Sbjct: 209 HNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEE 268 Query: 395 VVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 + +++G++MD P C +Y +M+ CWH + RPTF QL E L+ + T Sbjct: 269 LFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLT 319 >2OZO-A nrPDB Length = 613 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 132/469 (28%), Positives = 201/469 (42%), Gaps = 80/469 (17%) Query: 48 YKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYP--PETGLFL 105 +K + + + II + + E + A T MPW+H +TRE+AER LY G FL Sbjct: 131 WKLEGEALEQAII--SQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFL 188 Query: 106 VRE----------------------STNYPGDYT----------------LCVSCEGKVE 127 +R S + G Y L + +G + Sbjct: 189 LRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIY 248 Query: 128 HYRIMYHASKLSIDEEVYFENLMQLVEHYTTDA---------------------DGLCTR 166 + S S L T D Sbjct: 249 CLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPM 308 Query: 167 LIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQT-IGKGEFGDVMLGDYRGNK----VAV 221 + V E + +E L L + +G G FG V G YR K VA+ Sbjct: 309 PMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAI 368 Query: 222 KCIKN---DATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL 278 K +K A + + EA +M QL + +V+L+GV E L +V E G L +L Sbjct: 369 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE--ALMLVMEMAGGGPLHKFL 426 Query: 279 RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 + R + + + V M+YLE NFVHR+LAARNVL+ + AK+SDFGL+K Sbjct: 427 VGK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKA 485 Query: 339 A------SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392 + + GK P+KW APE + +KFS++SDVWS+G+ +WE S+G+ PY ++ Sbjct: 486 LGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 545 Query: 393 KDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 +V+ +E+G +M+ P CPP +Y +M +CW RP FL + +++ Sbjct: 546 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 Score = 72.2 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 3/108 (2%) Query: 81 PWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH-ASK 137 P+F+G I+R +AE L GLFL+R+ G Y L + + + H+ I Sbjct: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGT 68 Query: 138 LSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYR 185 +I +L E Y+ D DGL L KP + Q + Sbjct: 69 YAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFD 116 >5EG3-A nrPDB Length = 334 Score = 291 bits (745), Expect = 4e-79, Method: Composition-based stats. Identities = 107/291 (36%), Positives = 170/291 (58%), Gaps = 33/291 (11%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGN---------KVAVKCIKNDATAQAF---L 234 W +L L + +G+G FG V++ + G VAVK +K+DAT + + Sbjct: 29 KWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 88 Query: 235 AEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD---- 289 +E +M + +H N++ LLG ++ G LY++ Y +KG+L +YLR+R + Sbjct: 89 SEMEMMKMIGKHKNIINLLGACTQD-GPLYVIVAYASKGNLREYLRARRPPGMELSPDIN 147 Query: 290 ----------CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA 339 L+ + + MEYL +HRDLAARNVLV+E+NV K++DFGL ++ Sbjct: 148 RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 207 Query: 340 SS-----TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD 394 ++ G+LPVKW APEAL ++ ++ +SDVWSFG+L+WEI++ G PYP IP+++ Sbjct: 208 NNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEE 267 Query: 395 VVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 + +++G++MD P C +Y +M++CWH + RPTF QL E L+ I T Sbjct: 268 LFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 318 >2Y6O-A nrPDB Length = 291 Score = 290 bits (743), Expect = 8e-79, Method: Composition-based stats. Identities = 107/281 (38%), Positives = 169/281 (60%), Gaps = 19/281 (6%) Query: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCIK---NDA 228 A EF + ++ +K+ + IG GEFG+V G + G + VA+K +K D Sbjct: 1 NQAVREFAK---EIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK 57 Query: 229 TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 + FL+EAS+M Q H N++ L GV+ + K + I+TEYM GSL +LR + Sbjct: 58 QRRDFLSEASIMGQFDHPNIIHLEGVVTKCKP-VMIITEYMENGSLDAFLR-KNDGRFTV 115 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASST 342 L+ + M+YL ++VHRDLAARN+LV+ + V KVSDFG+++ EA+ T Sbjct: 116 IQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT 175 Query: 343 QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 GK+P++WTAPEA+ +KF++ SDVWS+GI++WE+ S+G PY + +DV+ +E+G Sbjct: 176 TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG 235 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 Y++ P CP A++ +M +CW + + RP F Q+ L+ + Sbjct: 236 YRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKL 276 >6GQK-A nrPDB Length = 328 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 98/290 (33%), Positives = 152/290 (52%), Gaps = 32/290 (11%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIK---NDATAQAF 233 Y W L +T+G G FG V+ +G VAVK +K + +A Sbjct: 32 YDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREAL 91 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG---------- 282 ++E V++ L H N+V LLG L ++TEY G L+++LR + Sbjct: 92 MSELKVLSYLGNHENIVNLLGACTHGGPTL-VITEYCCYGDLLNFLRRKRDEFVPYKVAP 150 Query: 283 ----RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 + L + LL FS V + M +L N +HRDLAARN+L++ N+ K+ DFGL ++ Sbjct: 151 EDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARD 210 Query: 339 ASS-----TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP-L 392 + + +LPVKW APE++ ++ +SDVWS+GI LWE++S G PYP +P Sbjct: 211 IKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVD 270 Query: 393 KDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 +++G++M +P+ P +YD+MK CW D RPTF Q+ + +E Sbjct: 271 SKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEK 320 >4H1J-A nrPDB Length = 293 Score = 288 bits (737), Expect = 4e-78, Method: Composition-based stats. Identities = 102/275 (37%), Positives = 158/275 (57%), Gaps = 15/275 (5%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNK-----VAVKCIKNDAT---AQAFLAEASV 239 + + +++ L + +G+G FG+V G Y +K VAVK K D T + F++EA + Sbjct: 19 YGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVI 78 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 M L H ++V+L+G+I EE +I+ E G L YL R ++ L L+ +SL +C Sbjct: 79 MKNLDHPHIVKLIGIIEEEPT--WIIMELYPYGELGHYL-ERNKNSLKVLTLVLYSLQIC 135 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAP 355 +AM YLE N VHRD+A RN+LV+ K+ DFGL++ +LP+KW +P Sbjct: 136 KAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSP 195 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ ++F+T SDVW F + +WEI SFG+ P+ + KDV+ +EKG ++ PD CPP + Sbjct: 196 ESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVL 255 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL 450 Y +M CW D + RP F +L L + E + Sbjct: 256 YTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDI 290 >3SXS-A nrPDB Length = 268 Score = 287 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 116/270 (42%), Positives = 162/270 (60%), Gaps = 8/270 (2%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQL 243 L +E+ LL+ +G G+FG V LG ++G VAVK IK + ++ F EA M +L Sbjct: 1 GHMELKREEITLLKELGSGQFGVVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKL 60 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H LV+ GV +E +YIVTEY++ G L++YLRS G+ L LL+ DVCE M Sbjct: 61 SHPKLVKFYGVCSKEYP-IYIVTEYISNGCLLNYLRSHGKG-LEPSQLLEMCYDVCEGMA 118 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEALR 359 +LE + F+HRDLAARN LV D KVSDFG+T+ Q K PVKW+APE Sbjct: 119 FLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFH 178 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 K+S+KSDVW+FGIL+WE++S G++PY +VV +V +G+++ P +Y +M Sbjct: 179 YFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIM 238 Query: 420 KNCWHLDAATRPTFLQLREQLEHIRTHELH 449 +CWH RPTF QL +E +R + H Sbjct: 239 YSCWHELPEKRPTFQQLLSSIEPLREKDKH 268 >5L6P-A nrPDB Length = 298 Score = 286 bits (732), Expect = 2e-77, Method: Composition-based stats. Identities = 102/286 (35%), Positives = 163/286 (56%), Gaps = 21/286 (7%) Query: 174 EGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCIK--- 225 A EF + +++ +K+ + IG GEFG+V G + G + VA+K +K Sbjct: 3 SDPNEAVREFAK---EIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY 59 Query: 226 NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV 285 + + FL+EAS+M Q H N+++L GV+ + + + I+TE+M +L +LR Sbjct: 60 TERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRP-VMILTEFMENCALDSFLRL-NDGQ 117 Query: 286 LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT 345 L+ + M+YL N+VHRDLAARN+LV+ + V KVSDFGL++ Sbjct: 118 FTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSD 177 Query: 346 --------GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVP 397 GK+P++WTAPEA+ +KF++ SDVWS+GI++WE+ S+G PY + +DV+ Sbjct: 178 PTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIN 237 Query: 398 RVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 VE+ Y++ P CP A++ +M +CW D RP F Q+ L+ + Sbjct: 238 AVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKL 283 >3KUL-B nrPDB Length = 325 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 117/307 (38%), Positives = 171/307 (55%), Gaps = 20/307 (6%) Query: 156 YTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR 215 Y +P E A F R + + + + IG G+ G+V G R Sbjct: 15 YFQGKLPEPQFYAEPHTYEEPGRAGRSFTR---EIEASRIHIEKIIGSGDSGEVCYGRLR 71 Query: 216 --GNK---VAVKCIK---NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTE 267 G + VA+K +K + + FL+EAS+M Q H N+++L GV+ + + IVTE Sbjct: 72 VPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAM-IVTE 130 Query: 268 YMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV 327 YM GSL +LR+ L+ V M YL +VHRDLAARNVLV + V Sbjct: 131 YMENGSLDTFLRTHDGQ-FTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLV 189 Query: 328 AKVSDFGLTK------EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYS 381 KVSDFGL++ +A+ T GK+P++WTAPEA+ + FS+ SDVWSFG+++WE+ + Sbjct: 190 CKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLA 249 Query: 382 FGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 +G PY + +DV+ VE+GY++ AP GCP A++ +M +CWH D A RP F Q+ L+ Sbjct: 250 YGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLD 309 Query: 442 H-IRTHE 447 IR+ E Sbjct: 310 ALIRSPE 316 >2VWV-A nrPDB Length = 302 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 101/285 (35%), Positives = 160/285 (56%), Gaps = 21/285 (7%) Query: 175 GTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNK---VAVKCIK---N 226 A EF + +++ +K+ + IG GEFG+V G + G K VA+K +K Sbjct: 1 DPNEAVREFAK---EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYT 57 Query: 227 DATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVL 286 + + FL+EAS+M Q H N+++L GV+ + I+TE+M G+L +LR Sbjct: 58 ERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMP-VMILTEFMENGALDSFLRL-NDGQF 115 Query: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT- 345 L+ + M YL ++VHRDLAARN+LV+ + V KVSDFGL++ Sbjct: 116 TVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDP 175 Query: 346 -------GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 GK+P++WTAPEA+ +KF++ SD WS+GI++WE+ SFG PY + +DV+ Sbjct: 176 TETSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINA 235 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +E+ Y++ P CP +++ +M +CW D RP F Q+ L+ + Sbjct: 236 IEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKM 280 >3CJF-A nrPDB Length = 309 Score = 281 bits (719), Expect = 4e-76, Method: Composition-based stats. Identities = 103/291 (35%), Positives = 158/291 (54%), Gaps = 27/291 (9%) Query: 182 EFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDA---TAQ 231 + S W L L + +G+G FG V+ D G VAVK +K A + Sbjct: 16 PYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR 75 Query: 232 AFLAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG-------- 282 A ++E ++ + H N+V LLG + G L ++ E+ G+L YLRS+ Sbjct: 76 ALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKD 135 Query: 283 --RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 + L + L+ +S V + ME+L +HRDLAARN+L+SE NV K+ DFGL ++ Sbjct: 136 LYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIY 195 Query: 341 STQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 D +LP+KW APE + ++ ++ +SDVWSFG+LLWEI+S G PYP + + + Sbjct: 196 KDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEE 255 Query: 396 V-PRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 R+++G +M APD P +Y M +CWH + + RPTF +L E L ++ Sbjct: 256 FCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQ 306 >4PDO-A nrPDB Length = 299 Score = 280 bits (718), Expect = 7e-76, Method: Composition-based stats. Identities = 106/291 (36%), Positives = 161/291 (55%), Gaps = 20/291 (6%) Query: 168 IKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR---GNK---VAV 221 P E A +F ++ + + IG GEFG+V G + G K VA+ Sbjct: 12 QDPHTYEDPNQAVLKFTT---EIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAI 68 Query: 222 KCIK---NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL 278 K +K + FL EA +M Q H N+++L GVI + K + I+TEYM G+L +L Sbjct: 69 KTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKP-MMIITEYMENGALDKFL 127 Query: 279 RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK- 337 R + L+ + M+YL N+VHRDLAARN+LV+ + V KVSDFGL++ Sbjct: 128 REK-DGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRV 186 Query: 338 -----EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392 EA+ T GK+P++WTAPEA+ +KF++ SDVWSFGI++WE+ ++G PY + Sbjct: 187 LEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN 246 Query: 393 KDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +V+ + G+++ P CP A+Y +M CW + A RP F + L+ + Sbjct: 247 HEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKL 297 >4Y93-A nrPDB Length = 446 Score = 280 bits (716), Expect = 9e-76, Method: Composition-based stats. Identities = 115/259 (44%), Positives = 157/259 (60%), Gaps = 8/259 (3%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQL 243 W ++ K+L L+ +G G+FG V G +RG VA+K IK + ++ F+ EA VM L Sbjct: 181 GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 240 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H LVQL GV +++ ++I+TEYMA G L++YLR R LL+ DVCEAME Sbjct: 241 SHEKLVQLYGVCTKQRP-IFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAME 298 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359 YLE F+HRDLAARN LV++ V KVSDFG+T+ + T K PVKW +PE L Sbjct: 299 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLM 358 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 KFS+KSD+W+FG+L+WEIYS G++PY R + + +G ++ P VY +M Sbjct: 359 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIM 418 Query: 420 KNCWHLDAATRPTFLQLRE 438 +CWH A RPTF L Sbjct: 419 YSCWHEKADERPTFKILLS 437 >4XLV-A nrPDB Length = 328 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 104/287 (36%), Positives = 156/287 (54%), Gaps = 24/287 (8%) Query: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATAQ 231 + W ++ +++ LL+ +G+G FG V G+ R +VAVK + A+ + Sbjct: 25 PSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLR 84 Query: 232 A---FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS-------- 280 FL EASVM ++V+LLGV+ + + L +V E MA G L YLRS Sbjct: 85 ERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTL-VVMELMAHGDLKSYLRSLRPEAENN 143 Query: 281 RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 GR +++ + ++ + M YL FVHRDLAARN +V+ D K+ DFG+T++ Sbjct: 144 PGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY 203 Query: 341 STQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 T G LPV+W APE+L++ F+T SD+WSFG++LWEI S PY + + V Sbjct: 204 ETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQV 263 Query: 396 VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 + V G +D PD CP V D+M+ CW + RPTFL++ L+ Sbjct: 264 LKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKD 310 >5AMN-A nrPDB Length = 299 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 101/291 (34%), Positives = 159/291 (54%), Gaps = 24/291 (8%) Query: 176 TVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG---DYRG----NKVAVKCIKNDA 228 +V A W K L L +T+G+GEFG V+ +G VAVK +K +A Sbjct: 6 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA 65 Query: 229 TA---QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-- 283 + + L+E +V+ Q+ H ++++L G ++ G L ++ EY GSL +LR + Sbjct: 66 SPSELRDLLSEFNVLKQVNHPHVIKLYGACSQD-GPLLLIVEYAKYGSLRGFLRESRKVG 124 Query: 284 ------SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 337 L L+ F+ + + M+YL VHRDLAARN+LV+E K+SDFGL++ Sbjct: 125 PGYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR 184 Query: 338 EASST-----QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392 + + G++PVKW A E+L + ++T+SDVWSFG+LLWEI + G PYP IP Sbjct: 185 DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP 244 Query: 393 KDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + + ++ G++M+ PD C +Y +M CW + RP F + + LE + Sbjct: 245 ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM 295 >6E4F-A nrPDB Length = 290 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 114/259 (44%), Positives = 157/259 (60%), Gaps = 8/259 (3%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQL 243 W ++ K+L L+ +G G+FG V G +RG VA+K IK + ++ F+ EA VM L Sbjct: 24 GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 83 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H LVQL GV +++ ++I+TEYMA G L++YLR R LL+ DVCEAME Sbjct: 84 SHEKLVQLYGVCTKQRP-IFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAME 141 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359 YLE F+HRDLAARN LV++ V KVSDFGL++ + T K PV+W+ PE L Sbjct: 142 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM 201 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 KFS+KSD+W+FG+L+WEIYS G++PY R + + +G ++ P VY +M Sbjct: 202 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM 261 Query: 420 KNCWHLDAATRPTFLQLRE 438 +CWH A RPTF L Sbjct: 262 YSCWHEKADERPTFKILLS 280 >3QGY-A nrPDB Length = 286 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 112/263 (42%), Positives = 155/263 (58%), Gaps = 8/263 (3%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQA-FLAEASVMTQLR 244 ++ EL +Q IG G+FG V LG + +KVA+K IK + ++ F+ EA VM +L Sbjct: 21 HMVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIKEGSMSEDDFIEEAEVMMKLS 80 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H LVQL GV +E+ + +V E+M G L DYLR++ R + + LL LDVCE M Y Sbjct: 81 HPKLVQLYGVCLEQAP-ICLVFEFMEHGCLSDYLRTQ-RGLFAAETLLGMCLDVCEGMAY 138 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEALRE 360 LE +HRDLAARN LV E+ V KVSDFG+T+ Q T K PVKW +PE Sbjct: 139 LEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSF 198 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 ++S+KSDVWSFG+L+WE++S G++PY +VV + G+++ P VY +M Sbjct: 199 SRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMN 258 Query: 421 NCWHLDAATRPTFLQLREQLEHI 443 +CW RP F +L QL I Sbjct: 259 HCWKERPEDRPAFSRLLRQLAEI 281 >3BEA-A nrPDB Length = 333 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 109/324 (33%), Positives = 161/324 (49%), Gaps = 34/324 (10%) Query: 152 LVEHYTTDADGLCTRLIKPKVMEGTVA----AQDEFYRSGWALNMKELKLLQTIGKGEFG 207 V++ R + EG Y W L+ +T+G G FG Sbjct: 1 GVDYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFG 60 Query: 208 DVMLGDYRGN-------KVAVKCIKNDA---TAQAFLAEASVMTQL-RHSNLVQLLGVIV 256 V+ G KVAVK +K+ A +A ++E +M+ L +H N+V LLG Sbjct: 61 KVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT 120 Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGR------------SVLGGDCLLKFSLDVCEAMEY 304 G + ++TEY G L+++LR + R S L LL FS V + M + Sbjct: 121 H-GGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAF 179 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-----QDTGKLPVKWTAPEALR 359 L N +HRD+AARNVL++ +VAK+ DFGL ++ + + +LPVKW APE++ Sbjct: 180 LASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIF 239 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 + ++ +SDVWS+GILLWEI+S G PYP I V+ GY+M P P +Y + Sbjct: 240 DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSI 299 Query: 419 MKNCWHLDAATRPTFLQLREQLEH 442 M+ CW L+ RPTF Q+ L+ Sbjct: 300 MQACWALEPTHRPTFQQICSFLQE 323 >5KMM-A nrPDB Length = 329 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 96/308 (31%), Positives = 163/308 (52%), Gaps = 31/308 (10%) Query: 173 MEGTVAAQDEFYRSGWA--LNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKC 223 ++G + +++ + +++ L +G+G FG V L + VAVK Sbjct: 13 LQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKA 72 Query: 224 IKN--DATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR 281 +K ++ Q F EA ++T L+H ++V+ GV E + L +V EYM G L +LRS Sbjct: 73 LKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRP-LLMVFEYMRHGDLNRFLRSH 131 Query: 282 GRS-------------VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA 328 G LG LL + V M YL G +FVHRDLA RN LV + V Sbjct: 132 GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV 191 Query: 329 KVSDFGLTKEASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFG 383 K+ DFG++++ ST LP++W PE++ +KF+T+SDVWSFG++LWEI+++G Sbjct: 192 KIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG 251 Query: 384 RVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + P+ ++ + + + +G +++ P CPP VY +M+ CW + R + + +L+ + Sbjct: 252 KQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 311 Query: 444 -RTHELHL 450 + ++L Sbjct: 312 AQAPPVYL 319 >1FVR-A nrPDB Length = 327 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 100/281 (35%), Positives = 149/281 (53%), Gaps = 25/281 (8%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRG----NKVAVKCIKN---DATAQAFLAEASVMT 241 L+ ++K IG+G FG V+ + A+K +K + F E V+ Sbjct: 21 VLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLC 80 Query: 242 QL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--------------RSVL 286 +L H N++ LLG E +G LY+ EY G+L+D+LR S L Sbjct: 81 KLGHHPNIINLLGAC-EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTL 139 Query: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQD 344 LL F+ DV M+YL F+HRDLAARN+LV E+ VAK++DFGL++ E + Sbjct: 140 SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKT 199 Query: 345 TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404 G+LPV+W A E+L ++T SDVWS+G+LLWEI S G PY + ++ ++ +GY+ Sbjct: 200 MGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 259 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 ++ P C VYD+M+ CW RP+F Q+ L + Sbjct: 260 LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLE 300 >5FM2-A nrPDB Length = 355 Score = 275 bits (705), Expect = 2e-74, Method: Composition-based stats. Identities = 102/324 (31%), Positives = 164/324 (50%), Gaps = 38/324 (11%) Query: 157 TTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG---D 213 + + G + + +V A W K L L +T+G+GEFG V+ Sbjct: 28 SYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFH 87 Query: 214 YRG----NKVAVKCIKNDATA---QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVT 266 +G VAVK +K +A+ + L+E +V+ Q+ H ++++L G ++ G L ++ Sbjct: 88 LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQD-GPLLLIV 146 Query: 267 EYMAKGSLVDYLRSRGR----------------------SVLGGDCLLKFSLDVCEAMEY 304 EY GSL +LR + L L+ F+ + + M+Y Sbjct: 147 EYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQY 206 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-----QDTGKLPVKWTAPEALR 359 L VHRDLAARN+LV+E K+SDFGL+++ + G++PVKW A E+L Sbjct: 207 LAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF 266 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 + ++T+SDVWSFG+LLWEI + G PYP IP + + ++ G++M+ PD C +Y +M Sbjct: 267 DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLM 326 Query: 420 KNCWHLDAATRPTFLQLREQLEHI 443 CW + RP F + + LE + Sbjct: 327 LQCWKQEPDKRPVFADISKDLEKM 350 >2OGV-A nrPDB Length = 317 Score = 275 bits (705), Expect = 2e-74, Method: Composition-based stats. Identities = 103/284 (36%), Positives = 154/284 (54%), Gaps = 26/284 (9%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDA---TAQAF 233 Y W L+ +T+G G FG V+ G KVAVK +K+ A +A Sbjct: 29 YNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL 88 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC-- 290 ++E +M+ L +H N+V LLG G + ++TEY G L+++LR + + L + Sbjct: 89 MSELKIMSHLGQHENIVNLLGACTH-GGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGR 147 Query: 291 ------LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-- 342 LL FS V + M +L N +HRD+AARNVL++ +VAK+ DFGL ++ + Sbjct: 148 PLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSN 207 Query: 343 ---QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPR 398 + +LPVKW APE++ + ++ +SDVWS+GILLWEI+S G PYP I Sbjct: 208 YIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKL 267 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 V+ GY+M P P +Y +M+ CW L+ RPTF Q+ L+ Sbjct: 268 VKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 311 >3G0E-A nrPDB Length = 336 Score = 275 bits (704), Expect = 3e-74, Method: Composition-based stats. Identities = 98/292 (33%), Positives = 150/292 (51%), Gaps = 34/292 (11%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDA---TAQAF 233 Y W L +T+G G FG V+ G VAVK +K A +A Sbjct: 37 YDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREAL 96 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVL------ 286 ++E V++ L H N+V LLG L ++TEY G L+++LR + S + Sbjct: 97 MSELKVLSYLGNHMNIVNLLGACTIGGPTL-VITEYCCYGDLLNFLRRKRDSFICSKTSP 155 Query: 287 ----------GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT 336 + LL FS V + M +L N +HRDLAARN+L++ + K+ DFGL Sbjct: 156 AIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLA 215 Query: 337 KEASST-----QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP 391 ++ + + +LPVKW APE++ ++ +SDVWS+GI LWE++S G PYP +P Sbjct: 216 RDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMP 275 Query: 392 -LKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 +++G++M +P+ P +YD+MK CW D RPTF Q+ + +E Sbjct: 276 VDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 327 >4GS6-A nrPDB Length = 315 Score = 275 bits (704), Expect = 3e-74, Method: Composition-based stats. Identities = 69/261 (26%), Positives = 125/261 (47%), Gaps = 11/261 (4%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLV 249 ++ KE+++ + +G+G FG V +R VA+K I++++ +AF+ E ++++ H N+V Sbjct: 6 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIV 65 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 +L G + + +V EY GSL + L + + + L + + YL Sbjct: 66 KLYGACL---NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 309 N---FVHRDLAARNVLVSEDNVA-KVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFS 364 +HRDL N+L+ K+ DFG + + K W APE +S Sbjct: 123 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYS 182 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRI--PLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 K DV+S+GI+LWE+ + R P+ I P ++ V G + P + +M C Sbjct: 183 EKCDVFSWGIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRC 241 Query: 423 WHLDAATRPTFLQLREQLEHI 443 W D + RP+ ++ + + H+ Sbjct: 242 WSKDPSQRPSMEEIVKIMTHL 262 >4AT3-A nrPDB Length = 299 Score = 275 bits (703), Expect = 4e-74, Method: Composition-based stats. Identities = 92/291 (31%), Positives = 150/291 (51%), Gaps = 29/291 (9%) Query: 178 AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKN--DA 228 A D F + + + L + +G+G FG V L + VAVK +K+ D Sbjct: 1 GAMDTFVQH---IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDN 57 Query: 229 TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS---- 284 + F EA ++T L+H ++V+ GV VE L +V EYM G L +LR+ G Sbjct: 58 ARKDFHREAELLTNLQHEHIVKFYGVCVE-GDPLIMVFEYMKHGDLNKFLRAHGPDAVLM 116 Query: 285 -------VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 337 L +L + + M YL +FVHRDLA RN LV E+ + K+ DFG+++ Sbjct: 117 AEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 176 Query: 338 EASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392 + ST LP++W PE++ +KF+T+SDVWS G++LWEI+++G+ P+ ++ Sbjct: 177 DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSN 236 Query: 393 KDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +V+ + +G + P CP VY++M CW + R + L+++ Sbjct: 237 NEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 287 >3V5Q-A nrPDB Length = 297 Score = 275 bits (703), Expect = 4e-74, Method: Composition-based stats. Identities = 90/282 (31%), Positives = 150/282 (53%), Gaps = 29/282 (10%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKND--ATAQAFLAEASVM 240 + +++ L + +G+G FG V L + VAVK +K+ A + F EA ++ Sbjct: 12 IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL 71 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--------------RSVL 286 T L+H ++V+ GV + L +V EYM G L +LR+ G + L Sbjct: 72 TNLQHEHIVKFYGVCG-DGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGEL 130 Query: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-- 344 G +L + + M YL +FVHRDLA RN LV + + K+ DFG++++ ST Sbjct: 131 GLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR 190 Query: 345 ---TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 401 LP++W PE++ +KF+T+SDVWSFG++LWEI+++G+ P+ ++ +V+ + + Sbjct: 191 VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQ 250 Query: 402 GYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 G ++ P CP VYDVM CW + R ++ + L + Sbjct: 251 GRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHAL 292 >1LUF-A nrPDB Length = 343 Score = 274 bits (701), Expect = 5e-74, Method: Composition-based stats. Identities = 93/292 (31%), Positives = 147/292 (50%), Gaps = 38/292 (13%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATAQ---AFLAEAS 238 ++ ++ IG+G FG V G VAVK +K +A+A F EA+ Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 102 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR----------------- 281 +M + + N+V+LLGV K + ++ EYMA G L ++LRS Sbjct: 103 LMAEFDNPNIVKLLGVCAVGKP-MCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRA 161 Query: 282 -----GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT 336 G L L + V M YL FVHRDLA RN LV E+ V K++DFGL+ Sbjct: 162 RVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLS 221 Query: 337 KEASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP 391 + S +P++W PE++ +++T+SDVW++G++LWEI+S+G PY + Sbjct: 222 RNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMA 281 Query: 392 LKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 ++V+ V G + P+ CP +Y++M+ CW A RP+F + L+ + Sbjct: 282 HEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRM 333 >3KRL-A nrPDB Length = 335 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 107/326 (32%), Positives = 159/326 (48%), Gaps = 36/326 (11%) Query: 152 LVEHYTTDADGLCTRLIKPKVMEGTVA----AQDEFYRSGWALNMKELKLLQTIGKGEFG 207 V++ R + EG Y W L+ +T+G G FG Sbjct: 1 GVDYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFG 60 Query: 208 DVMLGDYRGN-------KVAVKCIKNDA---TAQAFLAEASVMTQL-RHSNLVQLLGVIV 256 V+ G KVAVK +K+ A +A ++E +M+ L +H N+V LLG Sbjct: 61 KVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT 120 Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSR--------------GRSVLGGDCLLKFSLDVCEAM 302 G + ++TEY G L+++LR + L LL FS V + M Sbjct: 121 H-GGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGM 179 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-----QDTGKLPVKWTAPEA 357 +L N +HRD+AARNVL++ +VAK+ DFGL ++ + + +LPVKW APE+ Sbjct: 180 AFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPES 239 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPDGCPPAVY 416 + + ++ +SDVWS+GILLWEI+S G PYP I V+ GY+M P P +Y Sbjct: 240 IFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIY 299 Query: 417 DVMKNCWHLDAATRPTFLQLREQLEH 442 +M+ CW L+ RPTF Q+ L+ Sbjct: 300 SIMQACWALEPTHRPTFQQICSFLQE 325 >4R7H-A nrPDB Length = 343 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 107/340 (31%), Positives = 167/340 (49%), Gaps = 52/340 (15%) Query: 141 DEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQT 200 ++ ++ +++E Y ++ I P + Y W L+ +T Sbjct: 11 GQKPKYQVRWKIIESYEGNS----YTFIDPTQLP---------YNEKWEFPRNNLQFGKT 57 Query: 201 IGKGEFGDVMLGDYRGN-------KVAVKCIKNDA---TAQAFLAEASVMTQL-RHSNLV 249 +G G FG V+ G KVAVK +K+ A +A ++E +M+ L +H N+V Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 117 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS---------------------VLGG 288 LLG G + ++TEY G L+++LR + + L Sbjct: 118 NLLGACTH-GGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLEL 176 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-----Q 343 LL FS V + M +L N +HRD+AARNVL++ +VAK+ DFGL ++ + + Sbjct: 177 RDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVK 236 Query: 344 DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKG 402 +LPVKW APE++ + ++ +SDVWS+GILLWEI+S G PYP I V+ G Sbjct: 237 GNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDG 296 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 Y+M P P +Y +M+ CW L+ RPTF Q+ L+ Sbjct: 297 YQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQITSFLQE 336 >3I81-A nrPDB Length = 315 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 97/289 (33%), Positives = 161/289 (55%), Gaps = 24/289 (8%) Query: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDAT 229 V+A D + W + +++ + + +G+G FG V G +G +VA+K + A+ Sbjct: 2 VSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAAS 61 Query: 230 AQA---FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS-- 284 + FL EASVM + ++V+LLGV+ + + L ++ E M +G L YLRS Sbjct: 62 MRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTL-VIMELMTRGDLKSYLRSLRPEME 120 Query: 285 ------VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 +++ + ++ + M YL N FVHRDLAARN +V+ED K+ DFG+T++ Sbjct: 121 NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRD 180 Query: 339 ASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK 393 T G LPV+W +PE+L++ F+T SDVWSFG++LWEI + PY + + Sbjct: 181 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE 240 Query: 394 DVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 V+ V +G +D PD CP ++++M+ CW + RP+FL++ ++ Sbjct: 241 QVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE 289 >4XUF-A nrPDB Length = 297 Score = 271 bits (694), Expect = 4e-73, Method: Composition-based stats. Identities = 111/292 (38%), Positives = 155/292 (53%), Gaps = 39/292 (13%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDA---TAQAFLAE 236 W + L+ + +G G FG VM G +VAVK +K A +A ++E Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSE 62 Query: 237 ASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR------------ 283 +MTQL H N+V LLG G +Y++ EY G L++YLRS+ Sbjct: 63 LKMMTQLGSHENIVNLLGACT-LSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQ 121 Query: 284 ---------SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG 334 +VL + LL F+ V + ME+LE + VHRDLAARNVLV+ V K+ DFG Sbjct: 122 KRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFG 181 Query: 335 LTKEASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR 389 L ++ S + +LPVKW APE+L E ++ KSDVWS+GILLWEI+S G PYP Sbjct: 182 LARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPG 241 Query: 390 IP-LKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 IP + ++ G+KMD P +Y +M++CW D+ RP+F L L Sbjct: 242 IPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 293 >3PPZ-A nrPDB Length = 309 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 88/269 (32%), Positives = 138/269 (51%), Gaps = 13/269 (4%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKND----ATAQAFLAEASVMT 241 + +L + + IG G FG V ++ G+ VAVK + FL E ++M Sbjct: 30 DDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMK 89 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG-RSVLGGDCLLKFSLDVCE 300 +LRH N+V +G + + L IVTEY+++GSL L G R L L + DV + Sbjct: 90 RLRHPNIVLFMGAVTQPPN-LSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAK 148 Query: 301 AMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAP 355 M YL N VHRDL + N+LV + KV DFGL++ +ST + +W AP Sbjct: 149 GMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAP 208 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPA 414 E LR++ + KSDV+SFG++LWE+ + + P+ + VV V K +++ P P Sbjct: 209 EVLRDEPSNEKSDVYSFGVILWELATL-QQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQ 267 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQLEHI 443 V +++ CW + RP+F + + L + Sbjct: 268 VAAIIEGCWTNEPWKRPSFATIMDLLRPL 296 >5X02-A nrPDB Length = 347 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 112/295 (37%), Positives = 156/295 (52%), Gaps = 39/295 (13%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDA---TAQAF 233 Y W + L+ + +G G FG VM G +VAVK +K A +A Sbjct: 39 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 98 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR--------- 283 ++E +MTQL H N+V LLG G +Y++ EY G L++YLRS+ Sbjct: 99 MSELKMMTQLGSHENIVNLLGACT-LSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEY 157 Query: 284 ------------SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVS 331 +VL + LL F+ V + ME+LE + VHRDLAARNVLV+ V K+ Sbjct: 158 ENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKIC 217 Query: 332 DFGLTKEASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP 386 DFGL ++ S + +LPVKW APE+L E ++ KSDVWS+GILLWEI+S G P Sbjct: 218 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP 277 Query: 387 YPRIP-LKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 YP IP + ++ G+KMD P +Y +M++CW D+ RP+F L L Sbjct: 278 YPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 332 >5GRN-A nrPDB Length = 356 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 110/306 (35%), Positives = 156/306 (50%), Gaps = 42/306 (13%) Query: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATA- 230 Y S W L L + +G G FG V+ G G KVAVK +K A + Sbjct: 32 PMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSS 91 Query: 231 --QAFLAEASVMTQLR-HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 QA ++E +MT L H N+V LLG + G +YI+TEY G LV+YL S L Sbjct: 92 EKQALMSELKIMTHLGPHLNIVNLLGACTKS-GPIYIITEYCFYGDLVNYLHKNRDSFLS 150 Query: 288 GD------------------------CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS 323 LL F+ V ME+L N VHRDLAARNVL++ Sbjct: 151 HKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLA 210 Query: 324 EDNVAKVSDFGLTKEA-----SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWE 378 + + K+ DFGL ++ ++ + LPVKW APE++ + ++T SDVWS+GILLWE Sbjct: 211 QGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWE 270 Query: 379 IYSFGRVPYPRIPLKDV-VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLR 437 I+S G PYP + + +++ GY+M PD VY++M CW+ + RP+F L Sbjct: 271 IFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLS 330 Query: 438 EQLEHI 443 E +E++ Sbjct: 331 EIVENL 336 >5U6B-A nrPDB Length = 307 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 95/275 (34%), Positives = 151/275 (54%), Gaps = 22/275 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGN----KVAVKCIK----NDATAQAFLAEASVMT 241 ++ ++ L +T+G+GEFG VM G + KVAVK +K + + FL+EA M Sbjct: 20 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 79 Query: 242 QLRHSNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRS----RGRSVLGGDCLL 292 + H N+++L+GV E ++ +M G L +L L L+ Sbjct: 80 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 139 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-----DTGK 347 KF D+ MEYL F+HRDLAARN +++E+ V+DFGL+K+ + K Sbjct: 140 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAK 199 Query: 348 LPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA 407 +PVKW A E+L ++ +++KSDVWSFG+ +WEI + G+ PYP + ++ + +G ++ Sbjct: 200 MPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ 259 Query: 408 PDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 P C +Y +M CW L+ RP+F +LRE LE+ Sbjct: 260 PADCLDGLYALMSRCWELNPQDRPSFTELREDLEN 294 >3QUP-A nrPDB Length = 323 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 98/280 (35%), Positives = 149/280 (53%), Gaps = 23/280 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGN-----KVAVKCIKND----ATAQAFLAEASVM 240 + ++ L + +GKGEFG V + KVAVK +K D + + FL EA+ M Sbjct: 20 IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACM 79 Query: 241 TQLRHSNLVQLLGVIVEE--KGGL---YIVTEYMAKGSLVDYLRS----RGRSVLGGDCL 291 + H ++ +L+GV + KG L ++ +M G L +L + L L Sbjct: 80 KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL 139 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TG 346 ++F +D+ MEYL NF+HRDLAARN +++ED V+DFGL+++ S Sbjct: 140 VRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS 199 Query: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 KLPVKW A E+L + ++ SDVW+FG+ +WEI + G+ PY I ++ + G ++ Sbjct: 200 KLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLK 259 Query: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTH 446 P C VYD+M CW D RP+F LR +LE+I H Sbjct: 260 QPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH 299 >3ZBF-A nrPDB Length = 322 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 102/295 (34%), Positives = 153/295 (51%), Gaps = 27/295 (9%) Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY-------RGN-KVAVKCIKN---DAT 229 + A ++L L +G G FG+V G G KVAVK +K D Sbjct: 21 QGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQE 80 Query: 230 AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVL--- 286 FL EA +M++ H N+++ LGV + + YI+ E M G L+ YLR + Sbjct: 81 KIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQ-YIILELMEGGDLLTYLRKARMATFYGP 139 Query: 287 --GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV-----SEDNVAKVSDFGLTKEA 339 L+ +D+ + YLE +F+HRDLAARN LV + + K+ DFGL ++ Sbjct: 140 LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI 199 Query: 340 SSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD 394 G LPV+W APE+L + F+T+SDVWSFGIL+WEI + G PYP D Sbjct: 200 YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLD 259 Query: 395 VVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELH 449 V+ V+ G +++ P CP ++++M CW + RPTF ++++QL+ R L+ Sbjct: 260 VLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLN 314 >3BBT-B nrPDB Length = 328 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 96/268 (35%), Positives = 147/268 (54%), Gaps = 17/268 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGN------KVAVKCIKNDATAQ---AFLAEASVM 240 L ELK ++ +G G FG V G + VA+K + + F+ EA +M Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 71 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + H +LV+LLGV + + +VT+ M G L++Y+ + +G LL + + + + Sbjct: 72 ASMDHPHLVRLLGVCLSPT--IQLVTQLMPHGCLLEYVHEHKDN-IGSQLLLNWCVQIAK 128 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-----DTGKLPVKWTAP 355 M YLE VHRDLAARNVLV N K++DFGL + + D GK+P+KW A Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMAL 188 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E + +KF+ +SDVWS+G+ +WE+ +FG PY IP +++ +EKG ++ P C V Sbjct: 189 ECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDV 248 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHI 443 Y VM CW +DA +RP F +L + + Sbjct: 249 YMVMVKCWMIDADSRPKFKELAAEFSRM 276 >3C1X-A nrPDB Length = 373 Score = 268 bits (685), Expect = 4e-72, Method: Composition-based stats. Identities = 98/266 (36%), Positives = 146/266 (54%), Gaps = 16/266 (6%) Query: 195 LKLLQTIGKGEFGDVMLG---DYRGNKV--AVK---CIKNDATAQAFLAEASVMTQLRHS 246 + + IG+G FG V G D G K+ AVK I + FL E +M H Sbjct: 91 VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP 150 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N++ LLG+ + +G +V YM G L +++R+ + L+ F L V + M++L Sbjct: 151 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKFLA 209 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-------TQDTGKLPVKWTAPEALR 359 FVHRDLAARN ++ E KV+DFGL ++ + KLPVKW A E+L+ Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQ 269 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 +KF+TKSDVWSFG+LLWE+ + G PYP + D+ + +G ++ P+ CP +Y+VM Sbjct: 270 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 329 Query: 420 KNCWHLDAATRPTFLQLREQLEHIRT 445 CWH A RP+F +L ++ I + Sbjct: 330 LKCWHPKAEMRPSFSELVSRISAIFS 355 >5HLW-A nrPDB Length = 299 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 99/266 (37%), Positives = 146/266 (54%), Gaps = 16/266 (6%) Query: 195 LKLLQTIGKGEFGDVMLG---DYRGNKV--AVK---CIKNDATAQAFLAEASVMTQLRHS 246 + + IG+G FG V G D G K+ AVK I + FL E +M H Sbjct: 22 VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP 81 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N++ LLG+ + +G +V YM G L +++R+ + L+ F L V + M+YL Sbjct: 82 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLA 140 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-------TQDTGKLPVKWTAPEALR 359 FVHRDLAARN ++ E KV+DFGL ++ + KLPVKW A E+L+ Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ 200 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 +KF+TKSDVWSFG+LLWE+ + G PYP + D+ + +G ++ P+ CP +Y+VM Sbjct: 201 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 260 Query: 420 KNCWHLDAATRPTFLQLREQLEHIRT 445 CWH A RP+F +L ++ I + Sbjct: 261 LKCWHPKAEMRPSFSELVSRISAIFS 286 >4HZS-A nrPDB Length = 341 Score = 265 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 96/268 (35%), Positives = 152/268 (56%), Gaps = 20/268 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY-----RGNKVAVKCIKNDATAQ-----AFLAEASV 239 + K+L+LL+ +G G FG V G++ + VAVKC+K D +Q F+ E + Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 68 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 M L H NL++L GV++ + +VTE GSL+D LR L L ++++ V Sbjct: 69 MHSLDHRNLIRLYGVVLTPP--MKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVA 125 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPVKWT 353 E M YLE F+HRDLAARN+L++ ++ K+ DFGL + D K+P W Sbjct: 126 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 185 Query: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-EKGYKMDAPDGCP 412 APE+L+ + FS SD W FG+ LWE++++G+ P+ + ++ ++ ++G ++ P+ CP Sbjct: 186 APESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP 245 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQL 440 +Y+VM CW RPTF+ LR+ L Sbjct: 246 QDIYNVMVQCWAHKPEDRPTFVALRDFL 273 >1U54-B nrPDB Length = 291 Score = 265 bits (677), Expect = 4e-71, Method: Composition-based stats. Identities = 97/282 (34%), Positives = 154/282 (54%), Gaps = 20/282 (7%) Query: 176 TVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY-----RGNKVAVKCIKNDATA 230 A + + K+L+LL+ +G G FG V G++ + VAVKC+K D + Sbjct: 1 GSAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLS 60 Query: 231 Q-----AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV 285 Q F+ E + M L H NL++L GV++ + +VTE GSL+D LR Sbjct: 61 QPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP--MKMVTELAPLGSLLDRLRKHQGHF 118 Query: 286 LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD- 344 L L ++++ V E M YLE F+HRDLAARN+L++ ++ K+ DFGL + D Sbjct: 119 L-LGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDH 177 Query: 345 -----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 K+P W APE+L+ + FS SD W FG+ LWE++++G+ P+ + ++ ++ Sbjct: 178 YVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKI 237 Query: 400 -EKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 ++G ++ P+ CP +Y+VM CW RPTF+ LR+ L Sbjct: 238 DKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFL 279 >3PLS-A nrPDB Length = 298 Score = 264 bits (676), Expect = 4e-71, Method: Composition-based stats. Identities = 101/260 (38%), Positives = 146/260 (56%), Gaps = 16/260 (6%) Query: 199 QTIGKGEFGDVMLGDYRGN-----KVAVK---CIKNDATAQAFLAEASVMTQLRHSNLVQ 250 + IGKG FG V G+Y + A+K I +AFL E +M L H N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 L+G+++ +G +++ YM G L+ ++RS R+ L+ F L V MEYL F Sbjct: 87 LIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNP-TVKDLISFGLQVARGMEYLAEQKF 145 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASST-------QDTGKLPVKWTAPEALREKKF 363 VHRDLAARN ++ E KV+DFGL ++ +LPVKWTA E+L+ +F Sbjct: 146 VHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYRF 205 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 +TKSDVWSFG+LLWE+ + G PY I D+ + +G ++ P+ CP ++Y VM+ CW Sbjct: 206 TTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCW 265 Query: 424 HLDAATRPTFLQLREQLEHI 443 D A RPTF L ++E I Sbjct: 266 EADPAVRPTFRVLVGEVEQI 285 >3DTC-A nrPDB Length = 271 Score = 264 bits (676), Expect = 4e-71, Method: Composition-based stats. Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 24/274 (8%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATA------QAFLAEASVMTQ 242 ++ EL L + IG G FG V + G++VAVK ++D + EA + Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 62 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L+H N++ L GV ++E L +V E+ G L L + + D L+ +++ + M Sbjct: 63 LKHPNIIALRGVCLKEPN-LCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIARGM 118 Query: 303 EYLEGN---NFVHRDLAARNVLVSE--------DNVAKVSDFGLTKEAS-STQDTGKLPV 350 YL +HRDL + N+L+ + + + K++DFGL +E +T+ + Sbjct: 119 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAY 178 Query: 351 KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-EKGYKMDAPD 409 W APE +R FS SDVWS+G+LLWE+ + G VP+ I V V + P Sbjct: 179 AWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLALPIPS 237 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 CP +M++CW+ D +RP+F + +QL I Sbjct: 238 TCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTI 271 >4UY9-A nrPDB Length = 323 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 84/276 (30%), Positives = 136/276 (49%), Gaps = 24/276 (8%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATA------QAFLAEASVMTQ 242 ++ EL L + IG G FG V + G++VAVK ++D + EA + Sbjct: 5 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 64 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L+H N++ L GV ++E L +V E+ G L L + + D L+ +++ + M Sbjct: 65 LKHPNIIALRGVCLKEPN-LCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIARGM 120 Query: 303 EYLEGN---NFVHRDLAARNVLVSE--------DNVAKVSDFGLTKEAS-STQDTGKLPV 350 YL +HRDL + N+L+ + + + K++DFGL +E +T+ + Sbjct: 121 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTY 180 Query: 351 KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-EKGYKMDAPD 409 W APE +R FS SDVWS+G+LLWE+ + G VP+ I V V + P Sbjct: 181 AWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLALPIPS 239 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 CP +M++CW+ D +RP+F + +QL I Sbjct: 240 TCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 275 >3PP0-A nrPDB Length = 338 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 96/283 (33%), Positives = 150/283 (53%), Gaps = 20/283 (7%) Query: 175 GTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKV----AVKCIKNDA 228 A R L EL+ ++ +G G FG V G + G V A+K ++ + Sbjct: 2 SGAAPNQALLR---ILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENT 58 Query: 229 TAQ---AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV 285 + + L EA VM + + +LLG+ + + +VT+ M G L+D++R R Sbjct: 59 SPKANKEILDEAYVMAGVGSPYVSRLLGICLTST--VQLVTQLMPYGCLLDHVRE-NRGR 115 Query: 286 LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EAS 340 LG LL + + + + M YLE VHRDLAARNVLV N K++DFGL + E Sbjct: 116 LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE 175 Query: 341 STQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE 400 D GK+P+KW A E++ ++F+ +SDVWS+G+ +WE+ +FG PY IP +++ +E Sbjct: 176 YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE 235 Query: 401 KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 KG ++ P C VY +M CW +D+ RP F +L + + Sbjct: 236 KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRM 278 >5VO2-A nrPDB Length = 300 Score = 262 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 80/260 (30%), Positives = 135/260 (51%), Gaps = 12/260 (4%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLR 244 W + +E+ LQ +G G G V LG + G +VAVK +++ + +L+ Sbjct: 4 EDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETD-----IKHLRKLK 58 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H N++ GV + I+ E+ A+G L + LR+ + L+ +S+ + M Y Sbjct: 59 HPNIITFKGVCTQ-APCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNY 115 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS--STQDTGKLPVKWTAPEALREKK 362 L + +HRDL + N+L++ D+V K+SDFG +KE S ST+ + V W APE +R + Sbjct: 116 LHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 175 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPDGCPPAVYDVMKN 421 S K D+WSFG++LWE+ + G +PY + ++ V + P CP +++ Sbjct: 176 VSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQ 234 Query: 422 CWHLDAATRPTFLQLREQLE 441 CW+ RP+F Q+ L+ Sbjct: 235 CWNSKPRNRPSFRQILLHLD 254 >3AOX-A nrPDB Length = 344 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 100/287 (34%), Positives = 148/287 (51%), Gaps = 24/287 (8%) Query: 178 AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATA 230 A + + K + L++ +G G FG+V G G +VAVK + + Sbjct: 32 AGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSE 91 Query: 231 QA---FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV-- 285 Q FL EA ++++ H N+V+ +GV ++ +I+ E MA G L +LR Sbjct: 92 QDELDFLMEALIISKFNHQNIVRCIGVSLQSLPR-FILLELMAGGDLKSFLRETRPRPSQ 150 Query: 286 ---LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEA 339 L LL + D+ +YLE N+F+HRD+AARN L++ VAK+ DFG+ ++ Sbjct: 151 PSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI 210 Query: 340 SSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD 394 K LPVKW PEA E F++K+D WSFG+LLWEI+S G +PYP ++ Sbjct: 211 YRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQE 270 Query: 395 VVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 V+ V G +MD P CP VY +M CW RP F + E++E Sbjct: 271 VLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE 317 >5X5O-A nrPDB Length = 310 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 82/267 (30%), Positives = 133/267 (49%), Gaps = 15/267 (5%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQL 243 S + +L+ + G G FG V + + +VAVK + EA +++ L Sbjct: 8 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------IEKEAEILSVL 61 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H N++Q GVI+E IVTEY + GSL DY+ S + D ++ ++ DV + M Sbjct: 62 SHRNIIQFYGVILEPPNY-GIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMH 120 Query: 304 YLEGN---NFVHRDLAARNVLVSEDNVAKVSDFGLTK-EASSTQDTGKLPVKWTAPEALR 359 YL +HRDL +RNV+++ D V K+ DFG ++ +T + W APE ++ Sbjct: 121 YLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQ 180 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-EKGYKMDAPDGCPPAVYDV 418 S D +S+G++LWE+ + VP+ + V V EK ++ P CP + ++ Sbjct: 181 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 239 Query: 419 MKNCWHLDAATRPTFLQLREQLEHIRT 445 + CW DA RP+F Q+ LE + Sbjct: 240 LHQCWEADAKKRPSFKQIISILESMSN 266 >4OLI-A nrPDB Length = 645 Score = 261 bits (668), Expect = 4e-70, Method: Composition-based stats. Identities = 99/285 (34%), Positives = 147/285 (51%), Gaps = 33/285 (11%) Query: 189 ALNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVKCIKNDATAQA---FLAEASV 239 + + LK ++ +G+G FG V L D G VAVK +K D Q + E + Sbjct: 349 VFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDI 408 Query: 240 MTQLRHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 + L H ++++ G + + L +V EY+ GSL DYL R +G LL F+ + Sbjct: 409 LRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQI 465 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKW 352 CE M YL +++HR+LAARNVL+ D + K+ DFGL K E ++ G PV W Sbjct: 466 CEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 525 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGR----VPYP----------RIPLKDVVPR 398 APE L+E KF SDVWSFG+ L+E+ + P ++ + + Sbjct: 526 YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL 585 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +E+G ++ PD CP VY +MKNCW +A+ RPTF L L+ + Sbjct: 586 LERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTV 630 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 67/250 (26%), Positives = 111/250 (44%), Gaps = 18/250 (7%) Query: 212 GDYRGNK--VAVKCIKNDA--TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTE 267 G RG + V +K + A AF AS+M+Q+ H++L + GV V + +VTE Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI-MVTE 146 Query: 268 YMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV 327 Y+ G L +LR R R + + + + A+ YLE N VH ++ RN+L++ + Sbjct: 147 YVEHGPLDVWLR-RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 205 Query: 328 -------AKVSDFGLTKEASSTQDTGKLPVKWTAPEALREK--KFSTKSDVWSFGILLWE 378 K+SD G+ + +++ + W APE L ST D W FG L E Sbjct: 206 AEGTSPFIKLSDPGVG-LGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLE 264 Query: 379 IYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 I G P + ++ +++ P CP + + C + RP+F + Sbjct: 265 ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CPQ-LATLTSQCLTYEPTQRPSFRTILR 322 Query: 439 QLEHIRTHEL 448 L ++ H L Sbjct: 323 DLTRLQPHNL 332 >5U6C-A nrPDB Length = 315 Score = 260 bits (666), Expect = 7e-70, Method: Composition-based stats. Identities = 102/279 (36%), Positives = 155/279 (55%), Gaps = 22/279 (7%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRGN-----KVAVKCIKNDATAQA----FLAEASV 239 ++ L L + +G+GEFG VM G+ + KVAVK +K D ++Q FL+EA+ Sbjct: 32 VIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAAC 91 Query: 240 MTQLRHSNLVQLLGVIVEEK----GGLYIVTEYMAKGSLVDYLR----SRGRSVLGGDCL 291 M H N+++LLGV +E ++ +M G L YL G + L Sbjct: 92 MKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTL 151 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-----DTG 346 LKF +D+ MEYL NF+HRDLAARN ++ +D V+DFGL+K+ S Sbjct: 152 LKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIA 211 Query: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 K+PVKW A E+L ++ +++KSDVW+FG+ +WEI + G PYP + ++ + G+++ Sbjct: 212 KMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLK 271 Query: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 P+ C +Y++M +CW D RPTF LR QLE + Sbjct: 272 QPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 310 >6DBM-A nrPDB Length = 318 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 101/285 (35%), Positives = 147/285 (51%), Gaps = 33/285 (11%) Query: 189 ALNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVKCIKNDATAQA---FLAEASV 239 + + LK ++ +G+G FG V L D G VAVK +K DA Q + E + Sbjct: 27 VFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDI 86 Query: 240 MTQLRHSNLVQLLGVIVE-EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 + L H ++++ G + L +V EY+ GSL DYL R +G LL F+ + Sbjct: 87 LRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQI 143 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKW 352 CE M YL +++HRDLAARNVL+ D + K+ DFGL K E ++ G PV W Sbjct: 144 CEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 203 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGR----VPYP----------RIPLKDVVPR 398 APE L+E KF SDVWSFG+ L+E+ + P ++ + + Sbjct: 204 YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL 263 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +E+G ++ PD CP VY +MKNCW +A+ RPTF L L+ + Sbjct: 264 LERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLIPILKTV 308 >6FEX-A nrPDB Length = 321 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 89/296 (30%), Positives = 145/296 (48%), Gaps = 46/296 (15%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGD----------------YRGNK--VAVKCIKNDAT-- 229 L+ + +G+G+FG+V L + +G+ VAVK ++ DAT Sbjct: 13 FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKN 72 Query: 230 -AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR------- 281 FL E +M++L+ N+++LLGV V++ L ++T+YM G L +L + Sbjct: 73 ARNDFLKEVKIMSRLKDPNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDKAA 131 Query: 282 ----GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 337 G + LL + + M YL NFVHRDLA RN LV E+ K++DFG+++ Sbjct: 132 EGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR 191 Query: 338 -----EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWE-IYSFGRVPYPRIP 391 + Q LP++W A E + KF+T SDVW+FG+ LWE + P+ ++ Sbjct: 192 NLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLT 251 Query: 392 LKDVVPRVEKGYK-------MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 + V+ + ++ + P CP +Y++M CW ++ RP F QL L Sbjct: 252 DEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL 307 >5GNK-A nrPDB Length = 297 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 94/283 (33%), Positives = 149/283 (52%), Gaps = 20/283 (7%) Query: 175 GTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKV----AVKCIKNDA 228 G A R L E K ++ +G G FG V G + G KV A+K ++ Sbjct: 4 GGEAPNQALLR---ILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT 60 Query: 229 TAQ---AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV 285 + + L EA VM + + ++ +LLG+ + + ++ + M G L+DY+R + Sbjct: 61 SPKANKEILDEAYVMASVDNPHVCRLLGICLTST--VQLIMQLMPFGCLLDYVREHKDN- 117 Query: 286 LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EAS 340 +G LL + + + + M YLE VHRDLAARNVLV K++DFGL K E Sbjct: 118 IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKE 177 Query: 341 STQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE 400 + GK+P+KW A E++ + ++ +SDVWS+G+ +WE+ +FG PY IP ++ +E Sbjct: 178 YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILE 237 Query: 401 KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 KG ++ P C VY +M CW +DA +RP F +L + + Sbjct: 238 KGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKM 280 >3LZB-A nrPDB Length = 327 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 92/268 (34%), Positives = 148/268 (55%), Gaps = 17/268 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY--RGNKV----AVKCIKNDATAQ---AFLAEASVM 240 L E K ++ +G G FG V G + G KV A+K ++ + + L EA VM Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 71 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + + ++ +LLG+ + + ++T+ M G L+DY+R + +G LL + + + + Sbjct: 72 ASVDNPHVCRLLGICLTST--VQLITQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIAK 128 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAP 355 M YLE VHRDLAARNVLV K++DFGL K E + GK+P+KW A Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 188 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ + ++ +SDVWS+G+ +WE+ +FG PY IP ++ +EKG ++ P C V Sbjct: 189 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 248 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHI 443 Y +M+ CW +DA +RP F +L + + Sbjct: 249 YMIMRKCWMIDADSRPKFRELIIEFSKM 276 >1U59-A nrPDB Length = 287 Score = 258 bits (659), Expect = 4e-69, Method: Composition-based stats. Identities = 96/255 (37%), Positives = 144/255 (56%), Gaps = 16/255 (6%) Query: 200 TIGKGEFGDVMLGDYRGNK----VAVKCIKN---DATAQAFLAEASVMTQLRHSNLVQLL 252 +G G FG V G YR K VA+K +K A + + EA +M QL + +V+L+ Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 GV E L +V E G L +L + R + + + V M+YLE NFVH Sbjct: 77 GVCQAEA--LMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEA------SSTQDTGKLPVKWTAPEALREKKFSTK 366 RDLAARNVL+ + AK+SDFGL+K + + GK P+KW APE + +KFS++ Sbjct: 134 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 193 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 SDVWS+G+ +WE S+G+ PY ++ +V+ +E+G +M+ P CPP +Y +M +CW Sbjct: 194 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 253 Query: 427 AATRPTFLQLREQLE 441 RP FL + +++ Sbjct: 254 WEDRPDFLTVEQRMR 268 >6BSD-A nrPDB Length = 876 Score = 258 bits (659), Expect = 4e-69, Method: Composition-based stats. Identities = 94/345 (27%), Positives = 151/345 (43%), Gaps = 62/345 (17%) Query: 153 VEHYTTDADGLCT------RLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEF 206 V HY P + G V L+ + +G+G+F Sbjct: 529 VPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVD----FPRSRLRFKEKLGEGQF 584 Query: 207 GDVMLGD----------------YRGNK--VAVKCIKNDAT---AQAFLAEASVMTQLRH 245 G+V L + +G+ VAVK ++ DAT FL E +M++L+ Sbjct: 585 GEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKD 644 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-----------------SVLGG 288 N+++LLGV V++ L ++T+YM G L +L + + Sbjct: 645 PNIIRLLGVCVQD-DPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISY 703 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQ 343 LL + + M YL NFVHRDLA RN LV E+ K++DFG+++ + Q Sbjct: 704 PMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQ 763 Query: 344 DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWE-IYSFGRVPYPRIPLKDVVPRVEKG 402 LP++W A E + KF+T SDVW+FG+ LWE + P+ ++ + V+ + Sbjct: 764 GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEF 823 Query: 403 YK-------MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 ++ + P CP +Y++M CW ++ RP F QL L Sbjct: 824 FRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL 868 >6DBN-A nrPDB Length = 316 Score = 258 bits (659), Expect = 5e-69, Method: Composition-based stats. Identities = 89/284 (31%), Positives = 146/284 (51%), Gaps = 31/284 (10%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY------RGNKVAVKCIKNDATAQAF---LAEASVM 240 + LK ++ +G+G FG V L Y G +VAVK +K ++ E ++ Sbjct: 32 FEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEIL 91 Query: 241 TQLRHSNLVQLLGVIVEEKGG-LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 L H N+V+ G+ E+ G + ++ E++ GSL +YL + ++ + LK+++ +C Sbjct: 92 RNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYL-PKNKNKINLKQQLKYAVQIC 150 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT------KEASSTQDTGKLPVKWT 353 + M+YL +VHRDLAARNVLV ++ K+ DFGLT KE + +D PV W Sbjct: 151 KGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY 210 Query: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGR--------------VPYPRIPLKDVVPRV 399 APE L + KF SDVWSFG+ L E+ ++ + ++ + +V + Sbjct: 211 APECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTL 270 Query: 400 EKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 ++G ++ P CP VY +M+ CW + R +F L E E + Sbjct: 271 KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL 314 >4UYA-A nrPDB Length = 340 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 85/274 (31%), Positives = 132/274 (48%), Gaps = 24/274 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATA------QAFLAEASVMTQL 243 + + L+L + IG G FG V ++G +VAVK + D ++ EA + L Sbjct: 23 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 82 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 RH N+++L GV ++ + L +V E+ G+L L R + L+ +++ + M Sbjct: 83 RHPNIIELRGVCLQ-QPHLCLVLEFARGGALNRALAGRR---IPPHVLVNWAVQIARGML 138 Query: 304 YLEGN---NFVHRDLAARNVLVSE--------DNVAKVSDFGLTKEAS-STQDTGKLPVK 351 YL +HRDL + N+L+ E + K++DFGL +E +T+ Sbjct: 139 YLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYA 198 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDG 410 W APE ++ FS SD+WS+G+LLWE+ + G VPY I V V + P Sbjct: 199 WMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPST 257 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 CP +MK CW D RP+F + EQL I Sbjct: 258 CPEPFAKLMKECWQQDPHIRPSFALILEQLTAIE 291 >4E20-A nrPDB Length = 290 Score = 255 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 97/287 (33%), Positives = 148/287 (51%), Gaps = 33/287 (11%) Query: 189 ALNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVKCIKNDATAQ---AFLAEASV 239 + + LK ++ +G+G FG V L D G VAVK +K Q + E + Sbjct: 4 VFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEI 63 Query: 240 MTQLRHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 + L H ++V+ G + + + +V EY+ GSL DYL R +G LL F+ + Sbjct: 64 LRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYL---PRHCVGLAQLLLFAQQI 120 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKW 352 CE M YL +++HR LAARNVL+ D + K+ DFGL K E ++ G PV W Sbjct: 121 CEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 180 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSF---GRVPYP-----------RIPLKDVVPR 398 APE L+E KF SDVWSFG+ L+E+ ++ + P+ ++ + + Sbjct: 181 YAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTEL 240 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 +E+G ++ PD CP +Y +MKNCW +A+ RPTF L L+ + Sbjct: 241 LERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQE 287 >3COM-A nrPDB Length = 314 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 126/282 (44%), Gaps = 14/282 (4%) Query: 165 TRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVK 222 +L P + +D + + +L+ +G+G +G V ++ G VA+K Sbjct: 5 VQLRNPPRRQLKKLDEDSLTKQPEEV----FDVLEKLGEGSYGSVYKAIHKETGQIVAIK 60 Query: 223 CIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG 282 + ++ Q + E S+M Q ++V+ G + L+IV EY GS+ D +R R Sbjct: 61 QVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTD-LWIVMEYCGAGSVSDIIRLRN 119 Query: 283 RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST 342 + L D + + +EYL +HRD+ A N+L++ + AK++DFG+ + + T Sbjct: 120 K-TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 178 Query: 343 ---QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 ++T W APE ++E ++ +D+WS GI E+ + G+ PY I + + Sbjct: 179 MAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEM-AEGKPPYADIHPMRAIFMI 237 Query: 400 EKGYK--MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 P+ D +K C R T QL + Sbjct: 238 PTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQH 279 >2QNJ-A nrPDB Length = 328 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 81/258 (31%), Positives = 126/258 (48%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDA----TAQAFLAEASVMTQLR 244 ++ +LL+TIGKG F V L + G +VA+K I + Q E +M L Sbjct: 10 HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 69 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H N+V+L VI EK LY++ EY + G + DYL + GR + + A++Y Sbjct: 70 HPNIVKLFEVIETEKT-LYLIMEYASGGEVFDYLVAHGR--MKEKEARSKFRQIVSAVQY 126 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS--STQDTGKLPVKWTAPEALREKK 362 VHRDL A N+L+ D K++DFG + E + DT + APE + KK Sbjct: 127 CHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKK 186 Query: 363 FS-TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 + + DVWS G++L+ + S G +P+ LK++ RV +G K P +++K Sbjct: 187 YDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKR 244 Query: 422 CWHLDAATRPTFLQLREQ 439 L+ R T Q+ + Sbjct: 245 FLVLNPIKRGTLEQIMKD 262 >5ES1-A nrPDB Length = 328 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 83/255 (32%), Positives = 125/255 (49%), Gaps = 14/255 (5%) Query: 194 ELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDA----TAQAFLAEASVMTQLRHSN 247 +LL+TIGKG F V L + G +VA+K I + Q E +M L H N Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +V+L VI EK LY+V EY + G + DYL S GR + + A+ Y Sbjct: 76 IVKLFEVIETEKT-LYLVMEYASAGEVFDYLVSHGR--MKEKEARAKFRQIVSAVHYCHQ 132 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS--STQDTGKLPVKWTAPEALREKKFS- 364 N VHRDL A N+L+ + K++DFG + E + S DT + APE + KK+ Sbjct: 133 KNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG 192 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWH 424 + D+WS G++L+ + S G +P+ LK++ RV +G K P +++ Sbjct: 193 PEVDIWSLGVILYTLVS-GSLPFDGHNLKELRERVLRG-KYRVPFYMSTDCESILRRFLV 250 Query: 425 LDAATRPTFLQLREQ 439 L+ A R T Q+ + Sbjct: 251 LNPAKRCTLEQIMKD 265 >2W1I-A nrPDB Length = 326 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 95/291 (32%), Positives = 154/291 (52%), Gaps = 31/291 (10%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDY------RGNKVAVKCIKN--DATAQAFLA 235 R + LK LQ +GKG FG V + Y G VAVK +++ + + F Sbjct: 32 DRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFER 91 Query: 236 EASVMTQLRHSNLVQLLGVIVE-EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 E ++ L+H N+V+ GV + L ++ EY+ GSL DYL+ + + LL++ Sbjct: 92 EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH-KERIDHIKLLQY 150 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT------KEASSTQDTGKL 348 + +C+ MEYL ++HRDLA RN+LV +N K+ DFGLT KE ++ G+ Sbjct: 151 TSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGES 210 Query: 349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSF----GRVPYP-----------RIPLK 393 P+ W APE+L E KFS SDVWSFG++L+E++++ P ++ + Sbjct: 211 PIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVF 270 Query: 394 DVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 ++ ++ ++ PDGCP +Y +M CW+ + RP+F L +++ IR Sbjct: 271 HLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR 321 >5KZ7-A nrPDB Length = 346 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 84/258 (32%), Positives = 129/258 (50%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK----NDATAQAFLAEASVMTQLR 244 ++ +LL+TIGKG F V L + G +VAVK I N ++ Q E +M L Sbjct: 31 HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLN 90 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H N+V+L VI EK LY+V EY + G + DYL + GR + + A++Y Sbjct: 91 HPNIVKLFEVIETEKT-LYLVMEYASGGEVFDYLVAHGR--MKEKEARAKFRQIVSAVQY 147 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKK 362 VHRDL A N+L+ D K++DFG + E + DT + APE + KK Sbjct: 148 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKK 207 Query: 363 FS-TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 + + DVWS G++L+ + S G +P+ LK++ RV +G K P +++K Sbjct: 208 YDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKK 265 Query: 422 CWHLDAATRPTFLQLREQ 439 L+ + R T Q+ + Sbjct: 266 FLILNPSKRGTLEQIMKD 283 >6FER-A nrPDB Length = 309 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 85/294 (28%), Positives = 141/294 (47%), Gaps = 43/294 (14%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRGNK------------------VAVKCIK---ND 227 K L + +G+G+FG+V L + G + VAVK ++ N Sbjct: 5 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 64 Query: 228 ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 FL E +M++L+ N++ LL V + + L ++TEYM G L +L Sbjct: 65 NARNDFLKEIKIMSRLKDPNIIHLLAVCITD-DPLCMITEYMENGDLNQFLSRHEPPNSS 123 Query: 288 GDCLL--------KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA 339 + + + M+YL NFVHRDLA RN LV ++ K++DFG+++ Sbjct: 124 SSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNL 183 Query: 340 SST-----QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGR-VPYPRIPLK 393 S Q LP++W + E++ KF+T SDVW+FG+ LWE ++F + PY ++ + Sbjct: 184 YSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE 243 Query: 394 DVVPRVEKGYK-------MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 V+ + ++ + P CP +VY +M +CW D RP+F ++ L Sbjct: 244 QVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 297 >3ZZW-A nrPDB Length = 289 Score = 255 bits (651), Expect = 4e-68, Method: Composition-based stats. Identities = 88/282 (31%), Positives = 142/282 (50%), Gaps = 30/282 (10%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDAT---AQAFLAEAS 238 +++ ++ ++ +G+ FG V G G VA+K +K+ A + F EA Sbjct: 5 EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAM 64 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--------------RS 284 + +L+H N+V LLGV+ +++ L ++ Y + G L ++L R +S Sbjct: 65 LRARLQHPNVVCLLGVVTKDQP-LSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKS 123 Query: 285 VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD 344 L + + MEYL ++ VH+DLA RNVLV + K+SD GL +E + Sbjct: 124 ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADY 183 Query: 345 -----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 LP++W APEA+ KFS SD+WS+G++LWE++S+G PY +DVV + Sbjct: 184 YKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMI 243 Query: 400 EKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 + PD CP VY +M CW+ + RP F + +L Sbjct: 244 RNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLR 285 >3IO7-A nrPDB Length = 313 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 94/286 (32%), Positives = 153/286 (53%), Gaps = 31/286 (10%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDY------RGNKVAVKCIKN--DATAQAFLAEASVM 240 + LK LQ +GKG FG V + Y G VAVK +++ + + F E ++ Sbjct: 24 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL 83 Query: 241 TQLRHSNLVQLLGVIVE-EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 L+H N+V+ GV + L ++ EY+ GSL DYL+ + + LL+++ +C Sbjct: 84 KSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH-KERIDHIKLLQYTSQIC 142 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT------KEASSTQDTGKLPVKWT 353 + MEYL ++HRDLA RN+LV +N K+ DFGLT KE ++ G+ P+ W Sbjct: 143 KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY 202 Query: 354 APEALREKKFSTKSDVWSFGILLWEIYSF----GRVPYP-----------RIPLKDVVPR 398 APE+L E KFS SDVWSFG++L+E++++ P ++ + ++ Sbjct: 203 APESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIEL 262 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 ++ ++ PDGCP +Y +M CW+ + RP+F L +++ IR Sbjct: 263 LKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR 308 >4LRM-A nrPDB Length = 334 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 94/287 (32%), Positives = 149/287 (51%), Gaps = 23/287 (8%) Query: 174 EGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKV----AVKCIKND 227 A R L E K ++ +G G FG V G + G KV A+K ++ Sbjct: 3 PSGEAPNQALLR---ILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA 59 Query: 228 ATAQ---AFLAEASVMTQLRHS---NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR 281 + + L EA VM + + ++ +LLG+ + + ++T+ M G L+DY+R Sbjct: 60 TSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTST--VQLITQLMPFGCLLDYVREH 117 Query: 282 GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK---- 337 + +G LL + + + + M YLE VHRDLAARNVLV K++DFGL K Sbjct: 118 KDN-IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA 176 Query: 338 -EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396 E + GK+P+KW A E++ + ++ +SDVWS+G+ +WE+ +FG PY IP ++ Sbjct: 177 EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEIS 236 Query: 397 PRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 +EKG ++ P C VY +M CW +DA +RP F +L + + Sbjct: 237 SILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKM 283 >5JN2-A nrPDB Length = 525 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 88/324 (27%), Positives = 139/324 (42%), Gaps = 25/324 (7%) Query: 142 EEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGT----VAAQDEFYRSGWALNMKELKL 197 E +YF+ + Q A +R G A F + A+ K Sbjct: 12 ENLYFQGMGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKG 71 Query: 198 LQTIGKGEFGDVMLGDYR--GNKVAVKCI-----KNDATAQAFLAEASVMTQLRHSNLVQ 250 + +GKG FG+V+L + G + AVK I K ++ L E ++ QL H N+++ Sbjct: 72 QRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMK 131 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 L E+KG Y+V E G L D + SR R + V + Y+ N Sbjct: 132 LYE-FFEDKGYFYLVGEVYTGGELFDEIISRKR--FSEVDAARIIRQVLSGITYMHKNKI 188 Query: 311 VHRDLAARNVLV---SEDNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALREKKFST 365 VHRDL N+L+ S+D ++ DFGL+ EAS + APE L + Sbjct: 189 VHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG-TYDE 247 Query: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPD--GCPPAVYDVMKNC 422 K DVWS G++L+ + S G P+ D++ +VEKG Y + P + D+++ Sbjct: 248 KCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKM 306 Query: 423 WHLDAATRPTFLQLREQLEHIRTH 446 + R + + E I+T+ Sbjct: 307 LTYVPSMRISARDALDH-EWIQTY 329 >4FL3-A nrPDB Length = 635 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 112/291 (38%), Positives = 155/291 (53%), Gaps = 19/291 (6%) Query: 169 KPKVMEGTVAAQDEFYRSGWALNMKELKLL-QTIGKGEFGDVMLGDYR----GNKVAVKC 223 +V E A +E L+ K L L + +G G FG V G Y+ VAVK Sbjct: 344 DTEVFESPFADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKI 403 Query: 224 IKNDAT----AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR 279 +KN+A LAEA+VM QL + +V+++G+ E +V E G L YL+ Sbjct: 404 LKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC--EAESWMLVMEMAELGPLNKYLQ 461 Query: 280 SRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-- 337 + +++ V M+YLE +NFVHRDLAARNVL+ + AK+SDFGL+K Sbjct: 462 QNRH--VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519 Query: 338 ----EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK 393 Q GK PVKW APE + KFS+KSDVWSFG+L+WE +S+G+ PY + Sbjct: 520 RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 579 Query: 394 DVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 +V +EKG +M P GCP +YD+M CW D RP F + +L + Sbjct: 580 EVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 53/115 (46%), Positives = 64/115 (55%), Gaps = 4/115 (3%) Query: 67 KREGVKAGTKLSLMPWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCEG 124 + E + A T MPWFHGKI+RE++E+ L+ G FL+R N G Y LC+ EG Sbjct: 153 QLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEG 211 Query: 125 KVEHYRIMYH-ASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVA 178 KV HYRI KLSI E F+ L QLVEHY+ ADGL L P GT Sbjct: 212 KVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQG 266 Score = 78.0 bits (191), Expect = 7e-15, Method: Composition-based stats. Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 3/118 (2%) Query: 81 PWFHGKITREQAERLLYPPE--TGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH-ASK 137 P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I Sbjct: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73 Query: 138 LSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKEL 195 +I + L +++ ++DGL L KP V + + ++E Sbjct: 74 YAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREY 131 >4CFF-A nrPDB Length = 571 Score = 251 bits (641), Expect = 5e-67, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 124/279 (44%), Gaps = 18/279 (6%) Query: 171 KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDA 228 + +G +A + + + + L T+G G FG V +G++ G+KVAVK + Sbjct: 14 VLFQGPMAEKQ---KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK 70 Query: 229 TAQ-----AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR 283 E + RH ++++L VI ++V EY++ G L DY+ GR Sbjct: 71 IRSLDVVGKIKREIQNLKLFRHPHIIKLYQVI-STPTDFFMVMEYVSGGELFDYICKHGR 129 Query: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 343 + + + A++Y + VHRDL NVL+ AK++DFGL+ S + Sbjct: 130 --VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 187 Query: 344 --DTGKLPVKWTAPEALREKKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE 400 T + APE + + + + D+WS G++L+ + G +P+ + + ++ Sbjct: 188 FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIR 246 Query: 401 KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 G P+ +V ++ + +D R T +RE Sbjct: 247 GGV-FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 284 >4REW-A nrPDB Length = 540 Score = 251 bits (641), Expect = 5e-67, Method: Composition-based stats. Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 15/260 (5%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQ-----AFLAEASVMTQ 242 + + L T+G G FG V +G + G+KVAVK + E + Sbjct: 3 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 62 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 RH ++++L VI +++V EY++ G L DY+ GR L + + + Sbjct: 63 FRHPHIIKLYQVI-STPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGV 119 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALRE 360 +Y + VHRDL NVL+ AK++DFGL+ S + T + APE + Sbjct: 120 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 179 Query: 361 KKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 + + + D+WS G++L+ + G +P+ + + ++ G P P+V ++ Sbjct: 180 RLYAGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGI-FYTPQYLNPSVISLL 237 Query: 420 KNCWHLDAATRPTFLQLREQ 439 K+ +D R + +RE Sbjct: 238 KHMLQVDPMKRASIKDIREH 257 >4LG4-A nrPDB Length = 299 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 65/252 (25%), Positives = 120/252 (47%), Gaps = 10/252 (3%) Query: 195 LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLL 252 +L+ +G+G +G V ++ G VA+K + ++ Q + E S+M Q +V+ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYY 72 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 G + L+IV EY GS+ D +R R ++++ D + + +EYL +H Sbjct: 73 GSYFKNTD-LWIVMEYCGAGSVSDIIRLRNKTLI-EDEIATILKSTLKGLEYLHFMRKIH 130 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAPEALREKKFSTKSDV 369 R++ A N+L++ + AK++DFG+ + + T ++T W APE ++E ++ +D+ Sbjct: 131 RNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 190 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK--MDAPDGCPPAVYDVMKNCWHLDA 427 WS GI E+ + G+ PY I + + P+ D +K C + Sbjct: 191 WSLGITSIEM-AEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNP 249 Query: 428 ATRPTFLQLREQ 439 R T QL + Sbjct: 250 EQRATATQLLQH 261 >4CZT-A nrPDB Length = 464 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 68/258 (26%), Positives = 120/258 (46%), Gaps = 18/258 (6%) Query: 194 ELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQ-----AFLAEASVMTQLRHS 246 + +L +T+G+G F V G+ VA+K I + + E S M ++H Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N++++ V+ K +Y V E++ G L D + S GR L D K+ + A++Y Sbjct: 72 NVIRMFEVMA-SKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYCH 128 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TGKLPVKWTAPEALREK 361 HRDL N+L+ + KVSDFGL+ ++ T + APE + K Sbjct: 129 SRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNK 188 Query: 362 KFS-TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 + K+D+WS G++L+ + + G +P+ L + ++ K + P + ++K Sbjct: 189 GYDGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFK-AEFTCPPWFSASAKKLIK 246 Query: 421 NCWHLDAATRPTFLQLRE 438 + ATR TF ++ E Sbjct: 247 RILDPNPATRITFAEVIE 264 >5C26-A nrPDB Length = 299 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 112/291 (38%), Positives = 155/291 (53%), Gaps = 19/291 (6%) Query: 169 KPKVMEGTVAAQDEFYRSGWALNMKELKLL-QTIGKGEFGDVMLGDYR----GNKVAVKC 223 +V E A +E L+ K L L + +G G FG V G Y+ VAVK Sbjct: 2 DTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKI 61 Query: 224 IKNDAT----AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR 279 +KN+A LAEA+VM QL + +V+++G+ E +V E G L YL+ Sbjct: 62 LKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC--EAESWMLVMEMAELGPLNKYLQ 119 Query: 280 SRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-- 337 + +++ V M+YLE +NFVHRDLAARNVL+ + AK+SDFGL+K Sbjct: 120 QNRH--VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 177 Query: 338 ----EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK 393 Q GK PVKW APE + KFS+KSDVWSFG+L+WE +S+G+ PY + Sbjct: 178 RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 237 Query: 394 DVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 +V +EKG +M P GCP +YD+M CW D RP F + +L + Sbjct: 238 EVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 288 >4CFH-A nrPDB Length = 493 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 69/279 (24%), Positives = 124/279 (44%), Gaps = 18/279 (6%) Query: 171 KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDA 228 + +G +A + + + + L T+G G FG V +G + G+KVAVK + Sbjct: 14 VLFQGPMAEKQ---KHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQK 70 Query: 229 TAQ-----AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR 283 E + RH ++++L VI +++V EY++ G L DY+ GR Sbjct: 71 IRSLDVVGKIRREIQNLKLFRHPHIIKLYQVI-STPSDIFMVMEYVSGGELFDYICKNGR 129 Query: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 343 L + + ++Y + VHRDL NVL+ AK++DFGL+ S + Sbjct: 130 --LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 187 Query: 344 --DTGKLPVKWTAPEALREKKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE 400 T + APE + + + + D+WS G++L+ + G +P+ + + ++ Sbjct: 188 FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKIC 246 Query: 401 KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 G P P+V ++K+ +D R T +RE Sbjct: 247 DGI-FYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREH 284 >6AO5-A nrPDB Length = 362 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 65/252 (25%), Positives = 120/252 (47%), Gaps = 10/252 (3%) Query: 195 LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLL 252 +L+ +G+G +G V ++ G VA+K + ++ Q + E S+M Q +V+ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYY 71 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 G + L+IV EY GS+ D +R R ++++ D + + +EYL +H Sbjct: 72 GSYFKNTD-LWIVMEYCGAGSVSDIIRLRNKTLI-EDEIATILKSTLKGLEYLHFMRKIH 129 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAPEALREKKFSTKSDV 369 R++ A N+L++ + AK++DFG+ + + T ++T W APE ++E ++ +D+ Sbjct: 130 RNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 189 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK--MDAPDGCPPAVYDVMKNCWHLDA 427 WS GI E+ + G+ PY I + + P+ D +K C + Sbjct: 190 WSLGITSIEM-AEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNP 248 Query: 428 ATRPTFLQLREQ 439 R T QL + Sbjct: 249 EQRATATQLLQH 260 >5EZV-A nrPDB Length = 560 Score = 247 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 65/260 (25%), Positives = 117/260 (45%), Gaps = 15/260 (5%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQ-----AFLAEASVMTQ 242 + + L T+G G FG V +G++ G+KVAVK + E + Sbjct: 25 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 84 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 RH ++++L VI ++V EY++ G L DY+ GR + + + A+ Sbjct: 85 FRHPHIIKLYQVI-STPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAV 141 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALRE 360 +Y + VHRDL NVL+ AK++DFGL+ S + T + APE + Sbjct: 142 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 201 Query: 361 KKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 + + + D+WS G++L+ + G +P+ + + ++ G P+ +V ++ Sbjct: 202 RLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLL 259 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + +D R T +RE Sbjct: 260 MHMLQVDPLKRATIKDIREH 279 >3MA6-A nrPDB Length = 298 Score = 247 bits (632), Expect = 6e-66, Method: Composition-based stats. Identities = 80/279 (28%), Positives = 127/279 (45%), Gaps = 21/279 (7%) Query: 183 FYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI-----KNDATAQAFLA 235 F + A+ K + +GKG FG+V+L + G + AVK I K ++ L Sbjct: 22 FVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLR 81 Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E ++ QL H N+++L E+KG Y+V E G L D + SR R + Sbjct: 82 EVQLLKQLDHPNIMKLYE-FFEDKGYFYLVGEVYTGGELFDEIISRKR--FSEVDAARII 138 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTK--EASSTQDTGKLPV 350 V + Y+ N VHRDL N+L+ S+D ++ DFGL+ EAS Sbjct: 139 RQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTA 198 Query: 351 KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPD 409 + APE L + K DVWS G++L+ + S G P+ D++ +VEKG Y + P Sbjct: 199 YYIAPEVLHG-TYDEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELPQ 256 Query: 410 --GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTH 446 + D+++ + R + + E I+T+ Sbjct: 257 WKKVSESAKDLIRKMLTYVPSMRISARDALDH-EWIQTY 294 >4RED-A nrPDB Length = 351 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 65/260 (25%), Positives = 116/260 (44%), Gaps = 15/260 (5%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQ-----AFLAEASVMTQ 242 + + L T+G G FG V +G + G+ VAVK + E + Sbjct: 11 VKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKL 70 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 RH ++++L VI +++V EY++ G L DY+ GR L + + + Sbjct: 71 FRHPHIIKLYQVI-STPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGV 127 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALRE 360 +Y + VHRDL NVL+ AK++DFGL+ S + T + APE + Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Query: 361 KKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 + + + D+WS G++L+ + G +P+ + + ++ G P P+V ++ Sbjct: 188 RLYAGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGI-FYTPQYLNPSVISLL 245 Query: 420 KNCWHLDAATRPTFLQLREQ 439 K+ +D R + +RE Sbjct: 246 KHMLQVDPMKRASIKDIREH 265 >3MN3-A nrPDB Length = 271 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 66/259 (25%), Positives = 119/259 (45%), Gaps = 16/259 (6%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ-----AFLAEASVMTQL 243 ++ ++++T+G+G FG V L + G KVA+K I A+ E S + L Sbjct: 2 HIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLL 61 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 RH ++++L VI + K + +V EY A L DY+ R + + +F + A+E Sbjct: 62 RHPHIIKLYDVI-KSKDEIIMVIEY-AGNELFDYIVQRDK--MSEQEARRFFQQIISAVE 117 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREK 361 Y + VHRDL N+L+ E K++DFGL+ + T + APE + K Sbjct: 118 YCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGK 177 Query: 362 KF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 + + DVWS G++L+ + R+P+ + + + G P P ++K Sbjct: 178 LYAGPEVDVWSCGVILYVMLC-RRLPFDDESIPVLFKNISNGV-YTLPKFLSPGAAGLIK 235 Query: 421 NCWHLDAATRPTFLQLREQ 439 ++ R + ++ + Sbjct: 236 RMLIVNPLNRISIHEIMQD 254 >3NCG-A nrPDB Length = 486 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 72/261 (27%), Positives = 113/261 (43%), Gaps = 19/261 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKN----DATAQAFLAEASVMTQLRHS 246 + ++ +GKG FG+V+ R + AVK I + L E ++ +L H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+++L I+E+ YIV E G L D + R R + V + Y+ Sbjct: 82 NIMKLFE-ILEDSSSFYIVGELYTGGELFDEIIKRKR--FSEHDAARIIKQVFSGITYMH 138 Query: 307 GNNFVHRDLAARNVLVSE---DNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALREK 361 +N VHRDL N+L+ D K+ DFGL+ + ++ + APE LR Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG- 197 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPDG--CPPAVYDV 418 + K DVWS G++L+ + S G P+ D++ RVE G Y D P D+ Sbjct: 198 TYDEKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDL 256 Query: 419 MKNCWHLDAATRPTFLQLREQ 439 ++ + R T Q E Sbjct: 257 IRKMLTFHPSLRITATQCLEH 277 >1FOT-A nrPDB Length = 318 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 60/264 (22%), Positives = 121/264 (45%), Gaps = 14/264 (5%) Query: 191 NMKELKLLQTIGKGEFGDVML--GDYRGNKVAVKCIKND-----ATAQAFLAEASVMTQL 243 ++++ ++L+T+G G FG V L + G A+K +K + + E +++ + Sbjct: 4 SLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV 63 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H ++++ G ++ ++++ +Y+ G L LR R ++ +VC A+E Sbjct: 64 THPFIIRMWGTF-QDAQQIFMIMDYIEGGELFSLLRKSQR--FPNPVAKFYAAEVCLALE 120 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 YL + ++RDL N+L+ ++ K++DFG K T + APE + K + Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPY 180 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 + D WSFGIL++E+ + G P+ ++ ++ P V D++ Sbjct: 181 NKSIDWWSFGILIYEMLA-GYTPFYDSNTMKTYEKILN-AELRFPPFFNEDVKDLLSRLI 238 Query: 424 HLDAATRPTFLQLREQLEHIRTHE 447 D + R L+ E ++ H Sbjct: 239 TRDLSQRL--GNLQNGTEDVKNHP 260 >2YZA-A nrPDB Length = 276 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 64/260 (24%), Positives = 116/260 (44%), Gaps = 15/260 (5%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQ-----AFLAEASVMTQ 242 + + L T+G G FG V +G++ G+KVAVK + E + Sbjct: 8 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 67 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 RH ++++L VI ++V EY++ G L DY+ GR + + + A+ Sbjct: 68 FRHPHIIKLYQVI-STPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAV 124 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALRE 360 +Y + VHRDL NVL+ AK++DFGL+ S + + APE + Sbjct: 125 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISG 184 Query: 361 KKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 + + + D+WS G++L+ + G +P+ + + ++ G P+ +V ++ Sbjct: 185 RLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLL 242 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + +D R T +RE Sbjct: 243 MHMLQVDPLKRATIKDIREH 262 >3HZT-A nrPDB Length = 467 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 73/262 (27%), Positives = 118/262 (45%), Gaps = 20/262 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT-----AQAFLAEASVMTQLRH 245 + ++ +G G +G+V+L + G + A+K IK + + A L E +V+ QL H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+++L E+K Y+V E G L D + R + V YL Sbjct: 64 PNIMKLYE-FFEDKRNYYLVMEVYRGGELFDEIILRQK--FSEVDAAVIMKQVLSGTTYL 120 Query: 306 EGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALRE 360 +N VHRDL N+L+ S D + K+ DFGL+ E + APE LR Sbjct: 121 HKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR- 179 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPDG--CPPAVYD 417 KK+ K DVWS G++L+ + G P+ ++++ RVEKG + D PD Sbjct: 180 KKYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQ 238 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++K + + R + + Sbjct: 239 LVKLMLTYEPSKRISAEEALNH 260 >3DXN-A nrPDB Length = 287 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 73/262 (27%), Positives = 118/262 (45%), Gaps = 20/262 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT-----AQAFLAEASVMTQLRH 245 + ++ +G G +G+V+L + G + A+K IK + + A L E +V+ QL H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+++L E+K Y+V E G L D + R + V YL Sbjct: 81 PNIMKLYE-FFEDKRNYYLVMEVYRGGELFDEIILRQK--FSEVDAAVIMKQVLSGTTYL 137 Query: 306 EGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALRE 360 +N VHRDL N+L+ S D + K+ DFGL+ E + APE LR Sbjct: 138 HKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR- 196 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPDG--CPPAVYD 417 KK+ K DVWS G++L+ + G P+ ++++ RVEKG + D PD Sbjct: 197 KKYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQ 255 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++K + + R + + Sbjct: 256 LVKLMLTYEPSKRISAEEALNH 277 >5WNO-A nrPDB Length = 330 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 90/281 (32%), Positives = 141/281 (50%), Gaps = 17/281 (6%) Query: 178 AAQDEFYRSGWALNMKEL--KLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDA 228 A+ + EL KL + +G G FG V G Y + VA+K + D Sbjct: 5 ASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQ 64 Query: 229 TA-QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 + L EA+ M +LRH NL++++G + + G L IVT Y G+L ++L+ + LG Sbjct: 65 SQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDG-LKIVTIYRPLGNLQNFLKLHKEN-LG 122 Query: 288 GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT-- 345 + + + M+YLE VHRDLA RNVLV + N +++DFGL+K D+ Sbjct: 123 AREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSIT 182 Query: 346 ---GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 GK+ +KW A E + ++ SDVW+FG+ WEI +FG+ PY + + ++ G Sbjct: 183 IKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDG 242 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 ++ P C +Y + CW D +RP F L E+ + Sbjct: 243 NRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEF 283 >3DFA-A nrPDB Length = 286 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 72/261 (27%), Positives = 113/261 (43%), Gaps = 19/261 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKN----DATAQAFLAEASVMTQLRHS 246 + ++ +GKG FG+V+ R + AVK I + L E ++ +L H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+++L I+E+ YIV E G L D + R R + V + Y+ Sbjct: 82 NIMKLFE-ILEDSSSFYIVGELYTGGELFDEIIKRKR--FSEHDAARIIKQVFSGITYMH 138 Query: 307 GNNFVHRDLAARNVLVSE---DNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALREK 361 +N VHRDL N+L+ D K+ DFGL+ + ++ + APE LR Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG- 197 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPDG--CPPAVYDV 418 + K DVWS G++L+ + S G P+ D++ RVE G Y D P D+ Sbjct: 198 TYDEKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDL 256 Query: 419 MKNCWHLDAATRPTFLQLREQ 439 ++ + R T Q E Sbjct: 257 IRKMLTFHPSLRITATQCLEH 277 >4RGJ-A nrPDB Length = 520 Score = 241 bits (616), Expect = 5e-64, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 133/305 (43%), Gaps = 24/305 (7%) Query: 154 EHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVML-- 211 H ++ ++ I + F ++ + ++ K ++ +GKG FG+V+L Sbjct: 21 RHEMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSR 80 Query: 212 GDYRGNKVAVKCI-----KNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVT 266 + G++ A+K I K ++ L E ++ L H N+++L E+ Y+V+ Sbjct: 81 DKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYE-FFEDNNYYYLVS 139 Query: 267 EYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV---- 322 + G L D + SR R + + + Y+ NN VHRDL N+L+ Sbjct: 140 DVYTGGELFDEIISRKR--FYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKN 197 Query: 323 SEDNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIY 380 ED + K+ DFGL+ E S + AP+ L + K D+WS G++L+ + Sbjct: 198 KEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHG-TYDEKCDIWSCGVILYILL 256 Query: 381 SFGRVPYPRIPLKDVVPRVEKG---YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLR 437 S G P+ D++ +VE G + + D++K +A R + R Sbjct: 257 S-GCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISA---R 312 Query: 438 EQLEH 442 + LEH Sbjct: 313 DALEH 317 >3LIJ-A nrPDB Length = 494 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 72/261 (27%), Positives = 121/261 (46%), Gaps = 19/261 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIKNDATA----QAFLAEASVMTQLRHS 246 + + ++ +G G +G+V+L + V A+K I+ + + L E +V+ L H Sbjct: 37 EMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHP 96 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+++L E+K Y+V E G L D + R + V + YL Sbjct: 97 NIMKLYD-FFEDKRNYYLVMECYKGGELFDEIIHRMK--FNEVDAAVIIKQVLSGVTYLH 153 Query: 307 GNNFVHRDLAARNVLV---SEDNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALREK 361 +N VHRDL N+L+ +D + K+ DFGL+ E + APE LR K Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVLR-K 212 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPD--GCPPAVYDV 418 K+ K DVWS G++L+ + + G P+ ++++ +VEKG Y D+P+ D+ Sbjct: 213 KYDEKCDVWSIGVILFILLA-GYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDL 271 Query: 419 MKNCWHLDAATRPTFLQLREQ 439 +K D+ R + Q E Sbjct: 272 IKQMLQFDSQRRISAQQALEH 292 >3H4J-B nrPDB Length = 336 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 70/255 (27%), Positives = 116/255 (45%), Gaps = 16/255 (6%) Query: 195 LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCI-----KNDATAQAFLAEASVMTQLRHSN 247 + +T+G+G FG V L + KVA+K I K E S + LRH + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +++L VI + +V EY A G L DY+ + R + D +F + A+EY Sbjct: 71 IIKLYDVITTPTD-IVMVIEY-AGGELFDYIVEKKR--MTEDEGRRFFQQIICAIEYCHR 126 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKF-S 364 + VHRDL N+L+ ++ K++DFGL+ + T + APE + K + Sbjct: 127 HKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWH 424 + DVWS GI+L+ + GR+P+ + ++ +V PD P +++ Sbjct: 187 PEVDVWSCGIVLYVML-VGRLPFDDEFIPNLFKKVNSCV-YVMPDFLSPGAQSLIRRMIV 244 Query: 425 LDAATRPTFLQLREQ 439 D R T ++R Sbjct: 245 ADPMQRITIQEIRRD 259 >4QMW-A nrPDB Length = 310 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 66/277 (23%), Positives = 125/277 (45%), Gaps = 13/277 (4%) Query: 171 KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK--- 225 + V + ++ A + L+ IGKG FG+V G VA+K I Sbjct: 7 FMAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE 66 Query: 226 NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV 285 + + E +V++Q + + G +++ L+I+ EY+ GS +D L Sbjct: 67 AEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKD-TKLWIIMEYLGGGSALDLLE---PGP 122 Query: 286 LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-- 343 L + ++ + ++YL +HRD+ A NVL+SE K++DFG+ + + TQ Sbjct: 123 LDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK 182 Query: 344 -DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 +T W APE +++ + +K+D+WS GI E+ + G P+ + V+ + K Sbjct: 183 RNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIEL-ARGEPPHSELHPMKVLFLIPKN 241 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + + ++ C + + + RPT +L + Sbjct: 242 NPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKH 278 >4HVI-A nrPDB Length = 314 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 95/283 (33%), Positives = 145/283 (51%), Gaps = 30/283 (10%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDY------RGNKVAVKCIKNDATAQA--FLAEASVMT 241 + LK + +GKG FG V L Y G VAVK +++ Q F E ++ Sbjct: 7 FEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILK 66 Query: 242 QLRHSNLVQLLGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 L +V+ GV + L +V EY+ G L D+L+ R R+ L LL +S +C+ Sbjct: 67 ALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ-RHRARLDASRLLLYSSQICK 125 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT------KEASSTQDTGKLPVKWTA 354 MEYL VHRDLAARN+LV + K++DFGL K+ ++ G+ P+ W A Sbjct: 126 GMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYA 185 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGR---VPYPR----IPLKDVVPRVEK------ 401 PE+L + FS +SDVWSFG++L+E++++ P + + VP + + Sbjct: 186 PESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLE 245 Query: 402 -GYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 G ++ AP CP V+++MK CW RP+F L QL+ + Sbjct: 246 EGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDML 288 >5X3F-B nrPDB Length = 393 Score = 240 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 124/283 (43%), Gaps = 20/283 (7%) Query: 178 AAQDEFYRSGWALN------MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT 229 A E + W + + ++T+G G FG VML ++ GN A+K + Sbjct: 63 AKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKV 122 Query: 230 A-----QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS 284 + L E ++ + LV+L ++ LY+V EY+A G + +LR GR Sbjct: 123 VKLKQIEHTLNEKRILQAVNFPFLVKL-EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGR- 180 Query: 285 VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD 344 ++ + EYL + ++RDL N+L+ + +V+DFG K Sbjct: 181 -FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTW 239 Query: 345 TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404 T ++ APE + K ++ D W+ G+L++E+ + G P+ + ++ G K Sbjct: 240 TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-K 297 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 + P + D+++N +D R F L+ + I+ H+ Sbjct: 298 VRFPSHFSSDLKDLLRNLLQVDLTKR--FGNLKNGVNDIKNHK 338 >4UZD-A nrPDB Length = 287 Score = 240 bits (613), Expect = 8e-64, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 118/259 (45%), Gaps = 16/259 (6%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCI-----KNDATAQAFLAEASVMTQLR 244 +++ ++ + +GKG+FG+V L + +K A+K + + E + + LR Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H N+++L G + +Y++ EY G++ L + S + ++ A+ Y Sbjct: 67 HPNILRLYGYF-HDATRVYLILEYAPLGTVYREL--QKLSKFDEQRTATYITELANALSY 123 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-KLPVKWTAPEALREKKF 363 +HRD+ N+L+ K++DFG + A S++ T + + PE + + Sbjct: 124 CHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMH 183 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 K D+WS G+L +E + G+ P+ ++ R+ + + PD D++ Sbjct: 184 DEKVDLWSLGVLCYE-FLVGKPPFEANTYQETYKRISR-VEFTFPDFVTEGARDLISRLL 241 Query: 424 HLDAATRPTFLQLREQLEH 442 + + RP LRE LEH Sbjct: 242 KHNPSQRP---MLREVLEH 257 >4D28-A nrPDB Length = 446 Score = 240 bits (613), Expect = 8e-64, Method: Composition-based stats. Identities = 66/257 (25%), Positives = 116/257 (45%), Gaps = 16/257 (6%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKC-----IKNDATAQAFLAEASVMTQLRHS 246 + ++ +TIG+G F V G+ VA+K I + E S+M +RH Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V+L V+ K +YIV E++ G L D + +GR L D K+ + +A+ + Sbjct: 70 NIVRLYEVLA-SKSKIYIVLEFVTGGELFDRIVHKGR--LKEDESRKYFQQLVDAVAHCH 126 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTK---EASSTQDTGKLPVKWTAPEALREKKF 363 HRDL N+L+ + KVSDFGL+ E + + APE L + + Sbjct: 127 SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGY 186 Query: 364 S-TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 + +D+WS G++L+ I + G +P+ L + ++ + D P V ++ Sbjct: 187 DGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKI-NAAEFDCPPWFSAEVKFLIHRI 244 Query: 423 WHLDAATRPTFLQLREQ 439 + TR +++ Sbjct: 245 LDPNPKTRIQIQGIKKD 261 >2HAK-A nrPDB Length = 328 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 81/258 (31%), Positives = 125/258 (48%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDA----TAQAFLAEASVMTQLR 244 ++ +L +TIGKG F V L + G +VAVK I + Q E +M L Sbjct: 13 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILN 72 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H N+V+L VI EK LY+V EY + G + DYL + GR + + A++Y Sbjct: 73 HPNIVKLFEVIETEKT-LYLVMEYASGGEVFDYLVAHGR--MKEKEARAKFRQIVSAVQY 129 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKK 362 VHRDL A N+L+ D K++DFG + E + DT + APE + KK Sbjct: 130 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKK 189 Query: 363 FS-TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 + + DVWS G++L+ + S G +P+ LK++ RV +G K P +++K Sbjct: 190 YDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKK 247 Query: 422 CWHLDAATRPTFLQLREQ 439 L+ R + Q+ + Sbjct: 248 LLVLNPIKRGSLEQIMKD 265 >4YNZ-A nrPDB Length = 342 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 77/261 (29%), Positives = 136/261 (52%), Gaps = 21/261 (8%) Query: 195 LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFL----AEASVMTQLRHSNL 248 +L +T+GKG+ G V LG + KVA+K + + +++ L E +++ + H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 ++L V E K LY+V E+++ G L DYL +GR L KF + A+++ + Sbjct: 72 LKLHDV-YENKKYLYLVLEHVSGGELFDYLVKKGR--LTPKEARKFFRQIISALDFCHSH 128 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDTGKLPVKWTAPEALREKKFS-T 365 + HRDL N+L+ E N +++DFG+ S +T + PE +R +K+ Sbjct: 129 SICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 188 Query: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHL 425 K+DVWS G++L+ + G +P+ L+ ++ +V++G P PP +++ + Sbjct: 189 KADVWSCGVILFALL-VGALPFDDDNLRQLLEKVKRGV-FHMPHFIPPDCQSLLRGMIEV 246 Query: 426 DAATRPTFLQLREQLEHIRTH 446 DAA R T LEHI+ H Sbjct: 247 DAARRLT-------LEHIQKH 260 >4RA4-A nrPDB Length = 355 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 57/266 (21%), Positives = 112/266 (42%), Gaps = 14/266 (5%) Query: 175 GTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQA 232 + + + + + + L +GKG FG VML D +G + A+K +K D Q Sbjct: 2 SPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQD 61 Query: 233 -----FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 + E V+ L + L + LY V EY+ G L+ +++ G+ Sbjct: 62 DDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FK 119 Query: 288 GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQD 344 + ++ ++ + +L ++RDL NV++ + K++DFG+ KE T Sbjct: 120 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTR 179 Query: 345 TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK 404 T + APE + + + D W++G+LL+E+ + G+ P+ ++ + + + Sbjct: 180 TFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLA-GQPPFDGEDEDELFQSIME-HN 237 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATR 430 + P + K A R Sbjct: 238 VSYPKSLSKEAVSICKGLMTKHPAKR 263 >5HI2-A nrPDB Length = 283 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 19/271 (7%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 245 W + ++ + Q IG G FG V G + G+ VAVK + QAF E V+ + RH Sbjct: 13 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKML-TPQQLQAFKNEVGVLRKTRH 70 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N++ +G K L IVT++ SL +L + + L+ + M+YL Sbjct: 71 VNILLFMGY--STKPQLAIVTQWCEGSSLYHHLHA-SETKFEMKKLIDIARQTARGMDYL 127 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALR- 359 + +HRDL + N+ + EDN K+ DFGL S + + + W APE +R Sbjct: 128 HAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRM 187 Query: 360 --EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD-VVPRVEKGYKMD----APDGCP 412 +S +SDV++FGI+L+E+ + G++PY I +D ++ V +G CP Sbjct: 188 QDSNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCP 246 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + +M C RP+F ++ ++E + Sbjct: 247 KRMKRLMAECLKKKRDERPSFPRILAEIEEL 277 >2JC6-A nrPDB Length = 334 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 73/281 (25%), Positives = 122/281 (43%), Gaps = 21/281 (7%) Query: 176 TVAAQDEFYRSGWALNMKE----LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDA- 228 ++A ++ S W ++ + +T+G G F +V+L + + G AVKCI A Sbjct: 1 SMARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL 60 Query: 229 --TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVL 286 + E +V+ +++H N+V L I E LY+V + ++ G L D + +G Sbjct: 61 KGKESSIENEIAVLRKIKHENIVALED-IYESPNHLYLVMQLVSGGELFDRIVEKGF--Y 117 Query: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTKE--ASS 341 V +A+ YL VHRDL N+L E++ +SDFGL+K Sbjct: 118 TEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD 177 Query: 342 TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 401 T + APE L +K +S D WS G++ + + G P+ + ++ K Sbjct: 178 VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLC-GYPPFYDENDSKLFEQILK 236 Query: 402 -GYKMDAP--DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 Y+ D+P D + D ++N D R T Q Sbjct: 237 AEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARH 277 >4MVF-A nrPDB Length = 506 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 108/260 (41%), Gaps = 19/260 (7%) Query: 193 KELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQ--AFLAEASVMTQLRHSNL 248 + + + +G+G +G V G A+K K D F E +M +L H N+ Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNI 116 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 V+L E +Y++ E + L D + G + A+ YL Sbjct: 117 VKLYET-YENDNYIYLIMELCSGRELFDSIIENGS--FTEKNAATIMKQIFSAIFYLHSL 173 Query: 309 NFVHRDLAARNVLV---SEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKF 363 N VHRDL N L ++D++ K+ DFGL+K + + T + AP+ L + K+ Sbjct: 174 NIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVL-DGKY 232 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG----YKMDAPDGCPPAVYDVM 419 K D+WS G++++ + G P+ +V+ +V+KG Y+ D +++ Sbjct: 233 DKKCDIWSSGVIMYTLLC-GYPPFYGDTDNEVLKKVKKGEFCFYENDWGS-ISSDAKNLI 290 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + R T + Sbjct: 291 TKLLTYNPNERCTIEEALNH 310 >4WB7-A nrPDB Length = 405 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 63/264 (23%), Positives = 121/264 (45%), Gaps = 14/264 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQL 243 ++ + + ++T+G G FG VML ++ GN A+K + + L E ++ + Sbjct: 94 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 153 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 LV+L ++ LY+V EY+ G + +LR GR ++ + E Sbjct: 154 NFPFLVKL-EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFE 210 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 YL + ++RDL N+L+ + +V+DFG K T ++ APE + K + Sbjct: 211 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGY 270 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 + D W+ G+L++E+ + G P+ + ++ G K+ P + D+++N Sbjct: 271 NKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNLL 328 Query: 424 HLDAATRPTFLQLREQLEHIRTHE 447 +D R F L+ + I+ H+ Sbjct: 329 QVDLTKR--FGNLKNGVNDIKNHK 350 >6C9D-A nrPDB Length = 459 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 80/258 (31%), Positives = 124/258 (48%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDA----TAQAFLAEASVMTQLR 244 ++ +L +TIGKG F V L + G +VAVK I + Q E +M L Sbjct: 19 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILN 78 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H N+V+L VI EK LY+V EY + G + DYL + GR + + A++Y Sbjct: 79 HPNIVKLFEVIETEKT-LYLVMEYASGGEVFDYLVAHGR--MKEKEARAKFRQIVSAVQY 135 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKK 362 VHRDL A N+L+ D K++DFG + E + D + APE + KK Sbjct: 136 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKK 195 Query: 363 FS-TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 + + DVWS G++L+ + S G +P+ LK++ RV +G K P +++K Sbjct: 196 YDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKK 253 Query: 422 CWHLDAATRPTFLQLREQ 439 L+ R + Q+ + Sbjct: 254 LLVLNPIKRGSLEQIMKD 271 >5YKS-A nrPDB Length = 377 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 61/255 (23%), Positives = 106/255 (41%), Gaps = 14/255 (5%) Query: 195 LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDAT----AQAFLAEASVMTQLRHSNL 248 L +T+G+G F V L + G KVAVK I E M ++H N+ Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 V+L VI + + LY++ E G + DY+ L D K+ + A+ Y Sbjct: 97 VRLYEVI-DTQTKLYLILELGDGGDMFDYIMKHE-EGLNEDLAKKYFAQIVHAISYCHKL 154 Query: 309 NFVHRDLAARN-VLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKFS- 364 + VHRDL N V + + K++DFG + + + T + ++APE L ++ Sbjct: 155 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWH 424 D+WS G++L+ + G+ P+ + + + K P D++ Sbjct: 215 PAVDIWSLGVILF-MLVCGQPPFQEANDSETLTMIMDC-KYTVPSHVSKECKDLITRMLQ 272 Query: 425 LDAATRPTFLQLREQ 439 D R + ++ Sbjct: 273 RDPKRRASLEEIENH 287 >4FG9-A nrPDB Length = 320 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 122/275 (44%), Gaps = 18/275 (6%) Query: 178 AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDA---TAQA 232 A + ++ + +G G F +V+L + + + VA+KCI +A + Sbjct: 4 AVEGPRWKQAEDI-RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS 62 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 E +V+ +++H N+V L I E G LY++ + ++ G L D + +G Sbjct: 63 MENEIAVLHKIKHPNIVAL-DDIYESGGHLYLIMQLVSGGELFDRIVEKGF--YTERDAS 119 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVL---VSEDNVAKVSDFGLTKEASSTQ--DTGK 347 + V +A++YL VHRDL N+L + ED+ +SDFGL+K T Sbjct: 120 RLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTAC 179 Query: 348 LPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-GYKMD 406 + APE L +K +S D WS G++ + + G P+ + ++ K Y+ D Sbjct: 180 GTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLC-GYPPFYDENDAKLFEQILKAEYEFD 238 Query: 407 AP--DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 +P D + D +++ D R T Q + Sbjct: 239 SPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQH 273 >5IG1-A nrPDB Length = 344 Score = 237 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 61/279 (21%), Positives = 114/279 (40%), Gaps = 20/279 (7%) Query: 175 GTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQ- 231 G + + + +++K+ + IGKG F V G AVK I + Sbjct: 1 GPHMETETSFFDLYDVDLKDKR--SVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSS 58 Query: 232 ---AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 E + + L+H ++V + ++ Y+V EY++ G L D + +R Sbjct: 59 EINKIKREIGICSSLQHEHIVSMRRAF-RDESHFYLVFEYVSGGELFDEIVTRKF--YNE 115 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV---SEDNVAKVSDFGLT--KEASSTQ 343 + A+++ N +HRDL N+L+ + K++DFGL E T Sbjct: 116 KDASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTY 175 Query: 344 DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-G 402 + +PE +R + T DVW+ G++L+ I G P+ + + +++ Sbjct: 176 FGFAGTPGYLSPEVIRRVPYDTAVDVWACGVILY-ILLVGYPPFWEEDHQKLYAQIKNCQ 234 Query: 403 YKMDAP--DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 Y +P D A +++K + RPT +L + Sbjct: 235 YDFPSPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQH 273 >2JAM-A nrPDB Length = 304 Score = 237 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 15/259 (5%) Query: 192 MKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQA--FLAEASVMTQLRHSN 247 K ++ +G G F +V L G A+KCIK + E +V+ +++H N Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHEN 67 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +V L I E Y+V + ++ G L D + RG V V A++YL Sbjct: 68 IVTLED-IYESTTHYYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYLHE 124 Query: 308 NNFVHRDLAARNVLV---SEDNVAKVSDFGLTK-EASSTQDTGKLPVKWTAPEALREKKF 363 N VHRDL N+L E++ ++DFGL+K E + T + APE L +K + Sbjct: 125 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPY 184 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYDVMK 420 S D WS G++ + + G P+ + ++++G Y+ ++P D + D + Sbjct: 185 SKAVDCWSIGVITYILLC-GYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFIC 243 Query: 421 NCWHLDAATRPTFLQLREQ 439 + D R T + Sbjct: 244 HLLEKDPNERYTCEKALSH 262 >3D2K-A nrPDB Length = 272 Score = 237 bits (605), Expect = 8e-63, Method: Composition-based stats. Identities = 57/257 (22%), Positives = 115/257 (44%), Gaps = 13/257 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCI-----KNDATAQAFLAEASVMTQL 243 +++ + + +GKG+FG+V L R +K A+K + + E + + L Sbjct: 10 TLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHL 69 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 RH N+++L G + +Y++ EY G++ L+ R + ++ A+ Sbjct: 70 RHPNILRLYGYF-HDATRVYLILEYAPLGTVYRELQKLSR--FDEQRTATYITELANALS 126 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-KLPVKWTAPEALREKK 362 Y +HRD+ N+L+ + K++DFG + A S++ T + + PE + + Sbjct: 127 YCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 186 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 K D+WS G+L +E + G P+ ++ R+ + + PD D++ Sbjct: 187 HDEKVDLWSLGVLCYE-FLVGMPPFEAHTYQETYRRISR-VEFTFPDFVTEGARDLISRL 244 Query: 423 WHLDAATRPTFLQLREQ 439 +A+ R T ++ E Sbjct: 245 LKHNASQRLTLAEVLEH 261 >4APC-A nrPDB Length = 350 Score = 237 bits (604), Expect = 9e-63, Method: Composition-based stats. Identities = 59/271 (21%), Positives = 127/271 (46%), Gaps = 11/271 (4%) Query: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATA 230 + D + + +M++ LQ IG+G FG +L G + +K I + Sbjct: 8 SSGVDLGTENLYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKER 67 Query: 231 QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC 290 + E +V+ ++H N+VQ EE G LYIV +Y G L + ++ + D Sbjct: 68 EESRREVAVLANMKHPNIVQYRESF-EENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQ 126 Query: 291 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK--- 347 +L + + +C A++++ +HRD+ ++N+ +++D ++ DFG+ + +ST + + Sbjct: 127 ILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACI 186 Query: 348 LPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA 407 + +PE K ++ KSD+W+ G +L+E+ + + +K++V ++ G Sbjct: 187 GTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHA-FEAGSMKNLVLKIISGSFPPV 245 Query: 408 PDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 + ++ + + RP+ + E Sbjct: 246 SLHYSYDLRSLVSQLFKRNPRDRPSVNSILE 276 >5HIE-A nrPDB Length = 302 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 80/271 (29%), Positives = 130/271 (47%), Gaps = 19/271 (7%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 245 W + ++ + Q IG G FG V G + G+ VAVK + QAF E V+ + RH Sbjct: 29 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKML-TPQQLQAFKNEVGVLRKTRH 86 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N++ +G K L IVT++ SL +L + L+ + + M+YL Sbjct: 87 VNILLFMGY--STKPQLAIVTQWCEGSSLYHHLHIIE-TKFEMIKLIDIARQTAQGMDYL 143 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALR- 359 + +HRDL + N+ + ED K+ DFGL S + + + W APE +R Sbjct: 144 HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRM 203 Query: 360 --EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD-VVPRVEKGYKMD----APDGCP 412 + +S +SDV++FGI+L+E+ + G++PY I +D ++ V +GY CP Sbjct: 204 QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCP 262 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 A+ +M C RP F Q+ +E + Sbjct: 263 KAMKRLMAECLKKKRDERPLFPQILASIELL 293 >2WQN-A nrPDB Length = 310 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 120/268 (44%), Gaps = 17/268 (6%) Query: 191 NMKELKLLQTIGKGEFGDVML--GDYRGNKVAVKCIK-----NDATAQAFLAEASVMTQL 243 + ++ + IG+G+F +V G VA+K ++ + + E ++ QL Sbjct: 30 TLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL 89 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR--SRGRSVLGGDCLLKFSLDVCEA 301 H N+++ +E+ L IV E G L ++ + + ++ + K+ + +C A Sbjct: 90 NHPNVIKYYASFIED-NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSA 148 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEAL 358 +E++ +HRD+ NV ++ V K+ D GL + SS + +PE + Sbjct: 149 LEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPR--IPLKDVVPRVEKGYKMDAP-DGCPPAV 415 E ++ KSD+WS G LL+E+ + + P+ + L + ++E+ P D + Sbjct: 209 HENGYNFKSDIWSLGCLLYEMAAL-QSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEEL 267 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHI 443 ++ C + D RP + + + + Sbjct: 268 RQLVNMCINPDPEKRPDVTYVYDVAKRM 295 >3OMV-A nrPDB Length = 307 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 81/274 (29%), Positives = 132/274 (48%), Gaps = 22/274 (8%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK----NDATAQAFLAEASVMTQL 243 W + E+ L IG G FG V G + G+ VAVK +K QAF E +V+ + Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKT 89 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 RH N++ +G + ++ L IVT++ SL +L + + L+ + + M+ Sbjct: 90 RHVNILLFMGYMTKD--NLAIVTQWCEGSSLYKHLHVQE-TKFQMFQLIDIARQTAQGMD 146 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAPEAL 358 YL N +HRD+ + N+ + E K+ DFGL S + V W APE + Sbjct: 147 YLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVI 206 Query: 359 R---EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD-VVPRVEKGYKMDAP----DG 410 R FS +SDV+S+GI+L+E+ + G +PY I +D ++ V +GY Sbjct: 207 RMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYKN 265 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 CP A+ ++ +C RP F Q+ +E ++ Sbjct: 266 CPKAMKRLVADCVKKVKEERPLFPQILSSIELLQ 299 >3LMG-A nrPDB Length = 344 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 92/268 (34%), Positives = 143/268 (53%), Gaps = 17/268 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGN------KVAVKCIKNDATAQAFLAEASVM--- 240 EL+ L+ +G G FG V G + V +K I++ + Q+F A M Sbjct: 28 FKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI 87 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 L H+++V+LLG+ L +VT+Y+ GSL+D++R R LG LL + + + + Sbjct: 88 GSLDHAHIVRLLGLC--PGSSLQLVTQYLPLGSLLDHVRQH-RGALGPQLLLNWGVQIAK 144 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-----DTGKLPVKWTAP 355 M YLE + VHR+LAARNVL+ + +V+DFG+ K P+KW A Sbjct: 145 GMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMAL 204 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E++ K++ +SDVWS+G+ +WE+ +FG PY + L +V +EKG ++ P C V Sbjct: 205 ESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDV 264 Query: 416 YDVMKNCWHLDAATRPTFLQLREQLEHI 443 Y VM CW +D RPTF +L + + Sbjct: 265 YMVMVKCWMIDENIRPTFKELANEFTRM 292 >2XIK-A nrPDB Length = 294 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 68/273 (24%), Positives = 122/273 (44%), Gaps = 14/273 (5%) Query: 176 TVAAQDEFYRSGWALNMKE-LKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIK---NDAT 229 ++A F ++ +E L IGKG FG+V G + VA+K I + Sbjct: 1 SMAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDE 60 Query: 230 AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 + E +V++Q + + G ++ L+I+ EY+ GS +D L+ L Sbjct: 61 IEDIQQEITVLSQCDSPYITRYFGSYLKS-TKLWIIMEYLGGGSALDLLK---PGPLEET 116 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTG 346 + ++ + ++YL +HRD+ A NVL+SE K++DFG+ + + TQ +T Sbjct: 117 YIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTF 176 Query: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 W APE +++ + K+D+WS GI E+ + G P + V+ + K Sbjct: 177 VGTPFWMAPEVIKQSAYDFKADIWSLGITAIEL-AKGEPPNSDLHPMRVLFLIPKNSPPT 235 Query: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + ++ C + D RPT +L + Sbjct: 236 LEGQHSKPFKEFVEACLNKDPRFRPTAKELLKH 268 >2VN9-A nrPDB Length = 301 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 65/262 (24%), Positives = 110/262 (41%), Gaps = 19/262 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATA----QAFLAEASVMTQLRHS 246 E +L + +GKG F V G + A K I + Q EA + L+H Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V+L I EE G Y+V + + G L + + +R + E++ + Sbjct: 64 NIVRLHDSISEE-GFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILESVNHCH 120 Query: 307 GNNFVHRDLAARNVLV---SEDNVAKVSDFGLTKEASSTQDT---GKLPVKWTAPEALRE 360 N VHRDL N+L+ S+ K++DFGL E Q + +PE LR+ Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYD 417 + D+W+ G++L+ I G P+ + +++ G Y +P D P D Sbjct: 181 DPYGKPVDMWACGVILY-ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 239 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++ ++ A R T + + Sbjct: 240 LINKMLTINPAKRITASEALKH 261 >4FZF-B nrPDB Length = 283 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 65/253 (25%), Positives = 116/253 (45%), Gaps = 13/253 (5%) Query: 195 LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK---NDATAQAFLAEASVMTQLRHSNLV 249 L+ IGKG FG+V G VA+K I + + E +V++Q S + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 69 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 + G ++ L+I+ EY+ GS +D LR+ + ++ + ++YL Sbjct: 70 KYYGSYLK-GSKLWIIMEYLGGGSALDLLRA---GPFDEFQIATMLKEILKGLDYLHSEK 125 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTGKLPVKWTAPEALREKKFSTK 366 +HRD+ A NVL+SE K++ FG+ + + TQ +T W APE +++ + +K Sbjct: 126 KIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK 185 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 +D+WS GI E+ + G P + V+ + K + + + C + D Sbjct: 186 ADIWSLGITAIEL-AKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKD 244 Query: 427 AATRPTFLQLREQ 439 + RPT +L + Sbjct: 245 PSFRPTAKELLKH 257 >5N23-A nrPDB Length = 352 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 119/265 (44%), Gaps = 15/265 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQL 243 ++ + + ++T+G G FG VML ++ GN A+K + + L E + + Sbjct: 40 HLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAV 99 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 LV+L ++ LY+V EY G + +LR GR ++ + E Sbjct: 100 NFPFLVKL-EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFE 156 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-TGKLPVKWTAPEALREKK 362 YL + ++RDL N+L+ + KV+DFG K T ++ APE + K Sbjct: 157 YLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILSKG 216 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 ++ D W+ G+L++E+ + G P+ + ++ G K+ P + D+++N Sbjct: 217 YNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNL 274 Query: 423 WHLDAATRPTFLQLREQLEHIRTHE 447 +D R F L+ + I+ H+ Sbjct: 275 LQVDLTKR--FGNLKNGVNDIKNHK 297 >4CQG-A nrPDB Length = 331 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 69/258 (26%), Positives = 120/258 (46%), Gaps = 15/258 (5%) Query: 192 MKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLA---EASVMTQLRHS 246 +K +L +TIG G F V L + G VA+K + +A E + LRH Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQ 67 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 ++ QL V +E K +++V EY G L DY+ S+ R L + + A+ Y+ Sbjct: 68 HICQLYHV-LETKNKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQILSAVAYVH 124 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD----TGKLPVKWTAPEALREKK 362 + HRDL N+L E++ K+ DFGL + +D + + APE ++ K Sbjct: 125 SQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKS 184 Query: 363 F-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 + +++DVWS GILL+ + G +P+ + + ++ +G K + P P+ +++ Sbjct: 185 YLGSEADVWSMGILLYVLMC-GFLPFDDDNVMALYKKIMRG-KYEVPKWLSPSSILLLQQ 242 Query: 422 CWHLDAATRPTFLQLREQ 439 +D R + L Sbjct: 243 MLQVDPKKRISMRNLLNH 260 >3Q5I-A nrPDB Length = 504 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 67/271 (24%), Positives = 118/271 (43%), Gaps = 30/271 (11%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKN---------------DATAQAFLA 235 + ++ +G G +G+V+L + ++ A+K IK + + Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E S++ L H N+++L V E+K Y+VTE+ G L + + +R + Sbjct: 96 EISLLKSLDHPNIIKLFDVF-EDKKYFYLVTEFYEGGELFEQIINRHK--FDECDAANIM 152 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDN---VAKVSDFGLTKEASST--QDTGKLPV 350 + + YL +N VHRD+ N+L+ N K+ DFGL+ S Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTA 212 Query: 351 KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAPD 409 + APE L+ KK++ K DVWS G++++ + G P+ +D++ +VEKG Y D D Sbjct: 213 YYIAPEVLK-KKYNEKCDVWSCGVIMYILLC-GYPPFGGQNDQDIIKKVEKGKYYFDFND 270 Query: 410 --GCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 +++K D R T + Sbjct: 271 WKNISDEAKELIKLMLTYDYNKRCTAEEALN 301 >2BDW-A nrPDB Length = 362 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 114/272 (41%), Gaps = 18/272 (6%) Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA----QAFL 234 EF + + + +GKG F V ++ G + A K I + Q Sbjct: 17 SEFMMNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE 76 Query: 235 AEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 EA + +L+H N+V+L I EE Y+V + + G L + + +R Sbjct: 77 REARICRKLQHPNIVRLHDSIQEESFH-YLVFDLVTGGELFEDIVAREF--YSEADASHC 133 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEASSTQDTGK--LP 349 + E++ Y N VHR+L N+L++ K++DFGL E + ++ Sbjct: 134 IQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGT 193 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP 408 + +PE L++ +S D+W+ G++L+ I G P+ + +++ G Y +P Sbjct: 194 PGYLSPEVLKKDPYSKPVDIWACGVILY-ILLVGYPPFWDEDQHRLYAQIKAGAYDYPSP 252 Query: 409 --DGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 D P ++ + ++ R T Q + Sbjct: 253 EWDTVTPEAKSLIDSMLTVNPKKRITADQALK 284 >3PFQ-A nrPDB Length = 674 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 124/293 (42%), Gaps = 23/293 (7%) Query: 157 TTDADGLCTRLIKPKVMEGTVAAQDE-------FYRSGWA--LNMKELKLLQTIGKGEFG 207 + + L + + K+ +GT A +++ F +G + + + L +GKG FG Sbjct: 296 SEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFG 355 Query: 208 DVMLGDYRG--NKVAVKCIKNDATAQA-----FLAEASVMTQLRHSNLVQLLGVIVEEKG 260 VML + +G AVK +K D Q + E V+ + L + Sbjct: 356 KVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMD 415 Query: 261 GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320 LY V EY+ G L+ +++ GR + ++ ++ + +L+ ++RDL NV Sbjct: 416 RLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNV 473 Query: 321 LVSEDNVAKVSDFGLTKE---ASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLW 377 ++ + K++DFG+ KE T T + APE + + + D W+FG+LL+ Sbjct: 474 MLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLY 533 Query: 378 EIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 E+ + G+ P+ ++ + + + + P + K R Sbjct: 534 EMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMSKEAVAICKGLMTKHPGKR 584 >2V7O-A nrPDB Length = 336 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 61/262 (23%), Positives = 111/262 (42%), Gaps = 19/262 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDATA----QAFLAEASVMTQLRHS 246 + +L + +GKG F V + + A K I + Q EA + L+H Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V+L I EE G Y+V + + G L + + +R + E++ ++ Sbjct: 91 NIVRLHDSISEE-GFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQILESVNHIH 147 Query: 307 GNNFVHRDLAARNVLVSEDN---VAKVSDFGLTKEASSTQDT---GKLPVKWTAPEALRE 360 ++ VHRDL N+L++ K++DFGL E Q + +PE LR+ Sbjct: 148 QHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK 207 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYD 417 + D+W+ G++L+ I G P+ + +++ G Y +P D P + Sbjct: 208 DPYGKPVDIWACGVILY-ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 266 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++ ++ A R T Q + Sbjct: 267 LINQMLTINPAKRITADQALKH 288 >6FD3-A nrPDB Length = 300 Score = 234 bits (597), Expect = 6e-62, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 111/258 (43%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKC--IKNDATAQAFLAEASVMTQLRHS 246 K+ + IG+G G V L G +VA+K ++ + + E VM + ++ Sbjct: 20 PKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNP 79 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V L + L++V EY+A GSL D + + + + + +A+++L Sbjct: 80 NIVNYLDSYL-VGDELWVVMEYLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALDFLH 135 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTGKLPVKWTAPEALREKKF 363 N +HRD+ + N+L+ D K++DFG + + Q T W APE + K + Sbjct: 136 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY 195 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA--PDGCPPAVYDVMKN 421 K D+WS GI+ E+ G PY + + + P+ D + Sbjct: 196 GPKVDIWSLGIMAIEMV-EGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNR 254 Query: 422 CWHLDAATRPTFLQLREQ 439 C +D R + +L + Sbjct: 255 CLEMDVDRRGSAKELLQH 272 >2BPM-A nrPDB Length = 309 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 124/304 (40%), Gaps = 43/304 (14%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ----AFLAEASVM 240 G ++M+ + ++ IG+G +G V + G VA+K I+ D + + E S++ Sbjct: 1 GPLVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL 60 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 +L H N+V+LL VI E LY+V E++ L ++ + + + + + + + Sbjct: 61 KELNHPNIVKLLDVIHTE-NKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQ 118 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEA 357 + + + +HRDL +N+L++ + K++DFGL + T + + + APE Sbjct: 119 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178 Query: 358 LREKK-FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK--------------- 401 L K +ST D+WS G + E+ + R +P D + R+ + Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237 Query: 402 --GYKMDAPDGCPPAV-----------YDVMKNCWHLDAATRPTFLQLREQ--LEHIRTH 446 YK P ++ H D R + + + Sbjct: 238 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 Query: 447 ELHL 450 HL Sbjct: 298 VPHL 301 >4YZB-A nrPDB Length = 491 Score = 233 bits (596), Expect = 8e-62, Method: Composition-based stats. Identities = 80/281 (28%), Positives = 122/281 (43%), Gaps = 23/281 (8%) Query: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF- 233 A F + A K + +GKG FG+V+L + G + AVK I Q Sbjct: 14 AATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTD 73 Query: 234 ----LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 L E ++ +L H N+++L E+KG Y+VTE G L D + SR R Sbjct: 74 KELLLKEVELLKKLDHPNIMKLYE-FFEDKGYFYLVTEVYTGGELFDEIISRKR--FSEV 130 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTG 346 + V + Y+ N VHRDL N+L+ +D ++ DFGL+ ST+ Sbjct: 131 DAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMK 190 Query: 347 K--LPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-Y 403 + APE L + K DVWS G++L+ + S G P+ D++ +VEKG + Sbjct: 191 DKIGTAYYIAPEVLHG-TYDEKCDVWSTGVILYILLS-GCPPFNGANEFDILKKVEKGKF 248 Query: 404 KMDAPD--GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 D P D+++ R + R+ LEH Sbjct: 249 TFDLPQWKKVSEPAKDLIRKMLAYVPTMRISA---RDALEH 286 >4D2V-A nrPDB Length = 356 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 69/258 (26%), Positives = 117/258 (45%), Gaps = 15/258 (5%) Query: 192 MKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDA---TAQAFLAEASVMTQLRHS 246 +K +L +TIG G F V L + G VA+K + + E + LRH Sbjct: 28 LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQ 87 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 ++ QL V +E +++V EY G L DY+ S+ R L + + A+ Y+ Sbjct: 88 HICQLYHV-LETANKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQIVSAVAYVH 144 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD----TGKLPVKWTAPEALREKK 362 + HRDL N+L E + K+ DFGL + +D + + APE ++ K Sbjct: 145 SQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKS 204 Query: 363 F-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 + +++DVWS GILL+ + G +P+ +V ++ +G K D P P+ +++ Sbjct: 205 YLGSEADVWSMGILLYVLMC-GFLPFDDDTAAALVAKIMRG-KYDVPKWLSPSSILLLQQ 262 Query: 422 CWHLDAATRPTFLQLREQ 439 +D R + L Sbjct: 263 MLQVDPKKRISMKNLLNH 280 >2UV2-A nrPDB Length = 325 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 68/275 (24%), Positives = 117/275 (42%), Gaps = 24/275 (8%) Query: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCI--KNDATAQAFL 234 +D W + + +G G FG V + V A K I K++ + ++ Sbjct: 30 TRDLNPEDFWEI-------IGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYM 82 Query: 235 AEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 E ++ H N+V+LL E L+I+ E+ A G++ + R L + Sbjct: 83 VEIDILASCDHPNIVKLLDAFYYE-NNLWILIEFCAGGAVDAVMLELER-PLTESQIQVV 140 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVK 351 +A+ YL N +HRDL A N+L + D K++DFG++ + + T +D+ Sbjct: 141 CKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPY 200 Query: 352 WTAPEAL-----REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 W APE + +++ + K+DVWS GI L E+ P+ + V+ ++ K Sbjct: 201 WMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEI-EPPHHELNPMRVLLKIAKSEPPT 259 Query: 407 --APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 P D +K C + R T QL + Sbjct: 260 LAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQH 294 >3DAK-A nrPDB Length = 290 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 73/281 (25%), Positives = 124/281 (44%), Gaps = 31/281 (11%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDA---TAQAFLAEASVMTQ 242 W++N + +L + IG G V + KVA+K I + + L E M+Q Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ 64 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR------SRGRSVLGGDCLLKFSL 296 H N+V V K L++V + ++ GS++D ++ VL + Sbjct: 65 CHHPNIVSYYTSFV-VKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILR 123 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--------TGKL 348 +V E +EYL N +HRD+ A N+L+ ED +++DFG++ ++ D T Sbjct: 124 EVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVG 183 Query: 349 PVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV--------PRV 399 W APE + + + + K+D+WSFGI E+ + G PY + P V+ P + Sbjct: 184 TPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPSL 242 Query: 400 EKGYK-MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 E G + + + ++ C D RPT +L Sbjct: 243 ETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRH 283 >6FDY-U nrPDB Length = 276 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 121/275 (44%), Gaps = 22/275 (8%) Query: 187 GWALNMKE-LKLLQTIGKGEFGDVMLG---DYRGNKVAVKCI----KNDATAQAFLAEAS 238 GW + L + +G G + V VA+KC+ N A+ + L E Sbjct: 4 GWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIE 63 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 ++ +RH ++VQL + +Y++ E+ A G L ++ +R +L F + Sbjct: 64 ILKGIRHPHIVQLKD-FQWDSDNIYLIMEFCAGGDLSRFIHTRR--ILPEKVARVFMQQL 120 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVS--EDNVAKVSDFGLTKEASSTQDTG--KLPVKWTA 354 A+++L N H DL +N+L+S E K++DFG + S + + + A Sbjct: 121 ASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMA 180 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP--DGCP 412 PE + ++++ + D+WS G++L+E FG+ P+ ++ ++ ++ P Sbjct: 181 PEMVCQRQYDARVDLWSMGVILYEAL-FGQPPFASRSFSELEEKIRSNRVIELPLRPLLS 239 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQ----LEHI 443 D+++ D + R +F LEH+ Sbjct: 240 RDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHM 274 >5D9K-A nrPDB Length = 330 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 60/268 (22%), Positives = 125/268 (46%), Gaps = 19/268 (7%) Query: 191 NMKELKLLQTIGKGEFGDVML-----GDYRGNKVAVKCIKND----ATAQAFLAEASVMT 241 + + +LL+ +G+G FG V L G A+K +K E ++ Sbjct: 28 DPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILV 87 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 ++ H +V+L + +G LY++ +++ G L L + + + + ++ A Sbjct: 88 EVNHPFIVKLH-YAFQTEGKLYLILDFLRGGDLFTRLSKE--VMFTEEDVKFYLAELALA 144 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG---KLPVKWTAPEAL 358 +++L ++RDL N+L+ E+ K++DFGL+KE+ + V++ APE + Sbjct: 145 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 204 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 + + +D WSFG+L++E+ + G +P+ K+ + + K K+ P P + Sbjct: 205 NRRGHTQSADWWSFGVLMFEMLT-GTLPFQGKDRKETMTMILK-AKLGMPQFLSPEAQSL 262 Query: 419 MKNCWHLDAATRPTFLQLREQLEHIRTH 446 ++ + + A R + +E I+ H Sbjct: 263 LRMLFKRNPANRLGAG--PDGVEEIKRH 288 >3KK8-A nrPDB Length = 284 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 59/260 (22%), Positives = 111/260 (42%), Gaps = 18/260 (6%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA----QAFLAEASVMTQLRHS 246 + + +GKG F V ++ G + A K I + Q EA + +L+H Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 65 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V+L I EE Y+V + + G L + + +R + E++ Y Sbjct: 66 NIVRLHDSIQEESFH-YLVFDLVTGGELFEDIVAREF--YSEADASHCIQQILESIAYCH 122 Query: 307 GNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEASSTQDTGK--LPVKWTAPEALREK 361 N VHR+L N+L++ K++DFGL E + ++ + +PE L++ Sbjct: 123 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKD 182 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYDV 418 +S D+W+ G++L+ I G P+ + +++ G Y +P D P + Sbjct: 183 PYSKPVDIWACGVILY-ILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSL 241 Query: 419 MKNCWHLDAATRPTFLQLRE 438 + + ++ R T Q + Sbjct: 242 IDSMLTVNPKKRITADQALK 261 >5U6Y-A nrPDB Length = 461 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 107/260 (41%), Gaps = 19/260 (7%) Query: 195 LKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATA----QAFLAEASVMTQLRHSNL 248 +L + +GKG F V G + A K I + Q EA + L+H N+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 V+L I EE G Y++ + + G L + + +R + EA+ + Sbjct: 62 VRLHDSISEE-GHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQM 118 Query: 309 NFVHRDLAARNVLVSE---DNVAKVSDFGLTKEASSTQDT---GKLPVKWTAPEALREKK 362 VHRDL N+L++ K++DFGL E Q + +PE LR+ Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYDVM 419 + D+W+ G++L+ I G P+ + +++ G Y +P D P D++ Sbjct: 179 YGKPVDLWACGVILY-ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 237 Query: 420 KNCWHLDAATRPTFLQLREQ 439 ++ + R T + + Sbjct: 238 NKMLTINPSKRITAAEALKH 257 >5FG8-A nrPDB Length = 285 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 104/262 (39%), Gaps = 19/262 (7%) Query: 193 KELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDA----TAQAFLAEASVMTQLRHS 246 + + +GKG F V G + A K I Q EA + +L H Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V+L I EE Y+V + + G L + + +R + E++ + Sbjct: 74 NIVRLHDSIQEE-NYHYLVFDLVTGGELFEDIVAREF--YSEADASHCIQQILESVNHCH 130 Query: 307 GNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEASSTQDT---GKLPVKWTAPEALRE 360 N VHRDL N+L++ K++DFGL E + +PE L++ Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKK 190 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYD 417 + + D+W+ G++L+ I G P+ + +++ G Y +P D P + Sbjct: 191 EPYGKSVDIWACGVILY-ILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKN 249 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++ ++ R T + + Sbjct: 250 LINQMLTVNPNKRITAAEALKH 271 >3Q53-A nrPDB Length = 306 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 111/258 (43%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKC--IKNDATAQAFLAEASVMTQLRHS 246 K+ + IG+G G V + G +VA++ ++ + + E VM + ++ Sbjct: 19 PKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNP 78 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V L + L++V EY+A GSL D + + + + + +A+E+L Sbjct: 79 NIVNYLDSYL-VGDELWVVMEYLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALEFLH 134 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTGKLPVKWTAPEALREKKF 363 N +HRD+ + N+L+ D K++DFG + + Q T W APE + K + Sbjct: 135 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY 194 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA--PDGCPPAVYDVMKN 421 K D+WS GI+ E+ G PY + + + P+ D + Sbjct: 195 GPKVDIWSLGIMAIEMI-EGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNR 253 Query: 422 CWHLDAATRPTFLQLREQ 439 C +D R + +L + Sbjct: 254 CLEMDVEKRGSAKELIQH 271 >3BHH-A nrPDB Length = 295 Score = 231 bits (590), Expect = 5e-61, Method: Composition-based stats. Identities = 65/262 (24%), Positives = 111/262 (42%), Gaps = 19/262 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATA----QAFLAEASVMTQLRHS 246 E +L + IGKG F V G++ A K I + Q EA + L+HS Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V+L I EE G Y+V + + G L + + +R + EA+ + Sbjct: 64 NIVRLHDSISEE-GFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCH 120 Query: 307 GNNFVHRDLAARNVLVSEDN---VAKVSDFGLTKEASSTQDT---GKLPVKWTAPEALRE 360 VHRDL N+L++ K++DFGL E Q + +PE LR+ Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYD 417 + + D+W+ G++L+ I G P+ + +++ G Y +P D P + Sbjct: 181 EAYGKPVDIWACGVILY-ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 239 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++ ++ A R T + + Sbjct: 240 LINQMLTINPAKRITAHEALKH 261 >5DBX-A nrPDB Length = 328 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 73/281 (25%), Positives = 125/281 (44%), Gaps = 31/281 (11%) Query: 187 GWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDA---TAQAFLAEASVMT 241 GW + +L + IG G V L R +VA+K I + + L E M+ Sbjct: 5 GWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMS 64 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR------SRGRSVLGGDCLLKFS 295 Q H N+V V K L++V + ++ GS++D ++ VL + Sbjct: 65 QCSHPNVVTYYTSFV-VKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIL 123 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK-------- 347 +V E ++YL N +HRDL A N+L+ ED +++DFG++ ++ D + Sbjct: 124 KEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFV 183 Query: 348 LPVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV--------PR 398 W APE + + + + K+D+WSFGI E+ + G PY + P V+ P Sbjct: 184 GTPCWMAPEVMEQVRGYDFKADMWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPT 242 Query: 399 VEKGYK-MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 +E G + + + ++ C D + RPT +L + Sbjct: 243 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLK 283 >4JXF-A nrPDB Length = 266 Score = 231 bits (589), Expect = 6e-61, Method: Composition-based stats. Identities = 59/259 (22%), Positives = 111/259 (42%), Gaps = 14/259 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDAT-----AQAFLAEASVMTQL 243 +++ K+ +GKG F V + + G +VA+K I A Q E + QL Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +H ++++L E+ +Y+V E G + YL++R + + F + M Sbjct: 65 KHPSILELYNYF-EDSNYVYLVLEMCHNGEMNRYLKNRVK-PFSENEARHFMHQIITGML 122 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD---TGKLPVKWTAPEALRE 360 YL + +HRDL N+L++ + K++DFGL + + T + +PE Sbjct: 123 YLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATR 182 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 +SDVWS G + + + GR P+ +K+ + +V + P D++ Sbjct: 183 SAHGLESDVWSLGCMFYTLL-IGRPPFDTDTVKNTLNKVV-LADYEMPSFLSIEAKDLIH 240 Query: 421 NCWHLDAATRPTFLQLREQ 439 + A R + + + Sbjct: 241 QLLRRNPADRLSLSSVLDH 259 >2VZ6-A nrPDB Length = 313 Score = 230 bits (588), Expect = 7e-61, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 108/260 (41%), Gaps = 19/260 (7%) Query: 195 LKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATA----QAFLAEASVMTQLRHSNL 248 +L + +GKG F V G + A K I + Q EA + L+H N+ Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 V+L I EE G Y++ + + G L + + +R + EA+ + Sbjct: 84 VRLHDSISEE-GHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQM 140 Query: 309 NFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDT---GKLPVKWTAPEALREKK 362 VHRDL N+L++ + K++DFGL E Q + +PE LR+ Sbjct: 141 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 200 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYDVM 419 + D+W+ G++L+ I G P+ + +++ G Y +P D P D++ Sbjct: 201 YGKPVDLWACGVILY-ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 259 Query: 420 KNCWHLDAATRPTFLQLREQ 439 ++ + R T + + Sbjct: 260 NKMLTINPSKRITAAEALKH 279 >5XZW-A nrPDB Length = 471 Score = 230 bits (588), Expect = 7e-61, Method: Composition-based stats. Identities = 67/318 (21%), Positives = 129/318 (40%), Gaps = 36/318 (11%) Query: 147 ENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEF 206 +N + + + + + + VA + ++ ++ + +G+G F Sbjct: 157 QNKVDRIRSNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSIID-------EVVGQGAF 209 Query: 207 GDVMLG--DYRGNKVAVKCIKNDAT---AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGG 261 V G AVK I E V+ +L H +V+L G E+ Sbjct: 210 ATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKG-FYEDTES 268 Query: 262 LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVL 321 Y+V E+++ G L+D++ + G +G D + S + A++Y+ HRDL N+L Sbjct: 269 YYMVMEFVSGGDLMDFVAAHG--AVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNIL 326 Query: 322 VSEDN--VAKVSDFGLTKEA--SSTQDTGKLPVKWTAPEALREK-------------KFS 364 + +D+ + K++DFGL K S T + + APE +R K ++S Sbjct: 327 IEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYS 386 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP---DGCPPAVYDVMKN 421 + D+WS G L++ I + G +P+ + ++ +G + P D + + Sbjct: 387 SLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDS 445 Query: 422 CWHLDAATRPTFLQLREQ 439 +D R T + Sbjct: 446 LLQVDPNNRSTAAKALNH 463 >4YFF-A nrPDB Length = 311 Score = 230 bits (588), Expect = 8e-61, Method: Composition-based stats. Identities = 74/271 (27%), Positives = 129/271 (47%), Gaps = 15/271 (5%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK-----NDATAQAFLAEASV 239 S + L + E++ + IG G FG V G R VA+K + + + F E S+ Sbjct: 34 PSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSI 93 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 + QL H ++Q +G + + IVT+Y++ GSL L + R +L L ++DV Sbjct: 94 LCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKR-ILDLQSKLIIAVDVA 152 Query: 300 EAMEYLEG--NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS----TQDTGKLPVKWT 353 + MEYL +HRDL + N+L+ ED A V+DFG ++ S ++W Sbjct: 153 KGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWM 212 Query: 354 APEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY-KMDAPDGC 411 APE + +++ K+DV+S+ + LWEI + G +P+ + + + + Sbjct: 213 APEVFTQCTRYTIKADVFSYALCLWEILT-GEIPFAHLKPAAAAADMAYHHIRPPIGYSI 271 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 P + ++ W+ RP F ++ +LE Sbjct: 272 PKPISSLLIRGWNACPEGRPEFSEVVMKLEE 302 >2Z7Q-A nrPDB Length = 321 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 56/252 (22%), Positives = 116/252 (46%), Gaps = 17/252 (6%) Query: 191 NMKELKLLQTIGKGEFGDVMLGD-----YRGNKVAVKCIKND----ATAQAFLAEASVMT 241 + +LL+ +G+G FG V L G+ A+K +K E ++ Sbjct: 26 DPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILA 85 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 + H +V+L + +G LY++ +++ G L L + + + + ++ Sbjct: 86 DVNHPFVVKLH-YAFQTEGKLYLILDFLRGGDLFTRLSKE--VMFTEEDVKFYLAELALG 142 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG---KLPVKWTAPEAL 358 +++L ++RDL N+L+ E+ K++DFGL+KEA + V++ APE + Sbjct: 143 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV 202 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 + S +D WS+G+L++E+ + G +P+ K+ + + K K+ P + Sbjct: 203 NRQGHSHSADWWSYGVLMFEMLT-GSLPFQGKDRKETMTLILK-AKLGMPQFLSTEAQSL 260 Query: 419 MKNCWHLDAATR 430 ++ + + A R Sbjct: 261 LRALFKRNPANR 272 >2JDO-A nrPDB Length = 342 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 112/265 (42%), Gaps = 20/265 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDA-----TAQAFLAEASVMTQ 242 + M + L+ +GKG FG V+L + G A+K ++ + + E+ V+ Sbjct: 7 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 66 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 RH L L + L V EY G L +L V + + ++ A+ Sbjct: 67 TRHPFLTALK-YAFQTHDRLCFVMEYANGGELFFHLSRER--VFTEERARFYGAEIVSAL 123 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---TQDTGKLPVKWTAPEALR 359 EYL + V+RD+ N+++ +D K++DFGL KE S T T ++ APE L Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 + + D W G++++E+ GR+P+ + + + ++ P P ++ Sbjct: 184 DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELIL-MEEIRFPRTLSPEAKSLL 241 Query: 420 KNCWHLDAATR----PT-FLQLREQ 439 D R P+ ++ E Sbjct: 242 AGLLKKDPKQRLGGGPSDAKEVMEH 266 >3HDN-A nrPDB Length = 373 Score = 228 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 59/262 (22%), Positives = 112/262 (42%), Gaps = 20/262 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIKND-----ATAQAFLAEASVM-TQLR 244 + L+ IGKG FG V+L ++ +V AVK ++ + ++E +V+ ++ Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 97 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H LV L + LY V +Y+ G L +L+ ++ ++ A+ Y Sbjct: 98 HPFLVGLH-FSFQTADKLYFVLDYINGGELFYHLQRER--CFLEPRARFYAAEIASALGY 154 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK---EASSTQDTGKLPVKWTAPEALREK 361 L N V+RDL N+L+ ++DFGL K E +ST T ++ APE L ++ Sbjct: 155 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 214 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 + D W G +L+E+ +G P+ ++ + + + +++ Sbjct: 215 PYDRTVDWWCLGAVLYEML-YGLPPFYSRNTAEMYDNILN-KPLQLKPNITNSARHLLEG 272 Query: 422 CWHLDAATRP----TFLQLREQ 439 D R F++++ Sbjct: 273 LLQKDRTKRLGAKDDFMEIKSH 294 >3TXO-A nrPDB Length = 353 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 59/268 (22%), Positives = 112/268 (41%), Gaps = 14/268 (5%) Query: 173 MEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDA-- 228 E + S L + + ++ +GKG FG VML + G+ AVK +K D Sbjct: 3 KESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVIL 62 Query: 229 ---TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV 285 + + E +++ R+ + L + L+ V E++ G L+ +++ R Sbjct: 63 QDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR-- 120 Query: 286 LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SST 342 ++ ++ A+ +L ++RDL NVL+ + K++DFG+ KE T Sbjct: 121 FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT 180 Query: 343 QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 T + APE L+E + D W+ G+LL+E+ G P+ D+ + Sbjct: 181 TATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLC-GHAPFEAENEDDLFEAILND 239 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATR 430 ++ P ++K+ + R Sbjct: 240 -EVVYPTWLHEDATGILKSFMTKNPTMR 266 >4L42-A nrPDB Length = 346 Score = 228 bits (581), Expect = 5e-60, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 121/269 (44%), Gaps = 19/269 (7%) Query: 176 TVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGD-----YRGNKVAVKCIKNDATA 230 ++ R + + +LL+ +GKG +G V G A+K +K Sbjct: 1 GAMSETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIV 60 Query: 231 Q------AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS 284 + AE +++ +++H +V L+ + G LY++ EY++ G L +++ Sbjct: 61 RNAKDTAHTKAERNILEEVKHPFIVDLI-YAFQTGGKLYLILEYLSGGEL--FMQLEREG 117 Query: 285 VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SS 341 + D + ++ A+ +L ++RDL N++++ K++DFGL KE+ + Sbjct: 118 IFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGT 177 Query: 342 TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 401 T +++ APE L + D WS G L++++ + G P+ K + ++ K Sbjct: 178 VTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILK 236 Query: 402 GYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 K++ P D++K +AA+R Sbjct: 237 C-KLNLPPYLTQEARDLLKKLLKRNAASR 264 >5KCV-A nrPDB Length = 460 Score = 228 bits (581), Expect = 5e-60, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 114/286 (39%), Gaps = 21/286 (7%) Query: 170 PKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKND 227 P G + + + M E + L+ +GKG FG V+L + G A+K +K + Sbjct: 139 PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE 198 Query: 228 A-----TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG 282 L E V+ RH L L + L V EY G L +L Sbjct: 199 VIVAKDEVAHTLTENRVLQNSRHPFLTALK-YSFQTHDRLCFVMEYANGGELFFHLSRER 257 Query: 283 RSVLGGDCLLKFSLDVCEAMEYLEG-NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA-- 339 V D + ++ A++YL N V+RDL N+++ +D K++DFGL KE Sbjct: 258 --VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 315 Query: 340 -SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 +T T ++ APE L + + D W G++++E+ GR+P+ + + Sbjct: 316 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFEL 374 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRP-----TFLQLREQ 439 + ++ P P ++ D R ++ + Sbjct: 375 IL-MEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 419 >3MV5-A nrPDB Length = 342 Score = 227 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 64/266 (24%), Positives = 110/266 (41%), Gaps = 21/266 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDA-----TAQAFLAEASVMTQ 242 + M E + L+ +GKG FG V+L + G A+K +K + L E V+ Sbjct: 7 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 66 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 RH L L + L V EY G L +L V D + ++ A+ Sbjct: 67 SRHPFLTALK-YSFQTHDRLCFVMEYANGGELFFHLSRER--VFSEDRARFYGAEIVSAL 123 Query: 303 EYLEG-NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEAL 358 +YL N V+RDL N+++ +D K++DFGL KE +T T ++ APE L Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 + + D W G++++E+ GR+P+ + + + ++ P P + Sbjct: 184 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELIL-MEEIRFPRTLGPEAKSL 241 Query: 419 MKNCWHLDAATRP-----TFLQLREQ 439 + D R ++ + Sbjct: 242 LSGLLKKDPKQRLGGGSEDAKEIMQH 267 >3SOA-A nrPDB Length = 444 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 19/262 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATA----QAFLAEASVMTQLRHS 246 +E +L + +GKG F V G + A I + Q EA + L+H Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V+L I EE G Y++ + + G L + + +R + EA+ + Sbjct: 71 NIVRLHDSISEE-GHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCH 127 Query: 307 GNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEASSTQDT---GKLPVKWTAPEALRE 360 VHR+L N+L++ K++DFGL E Q + +PE LR+ Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP--DGCPPAVYD 417 + D+W+ G++L+ I G P+ + +++ G Y +P D P D Sbjct: 188 DPYGKPVDLWACGVILY-ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 246 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++ ++ + R T + + Sbjct: 247 LINKMLTINPSKRITAAEALKH 268 >4RLP-A nrPDB Length = 288 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 118/255 (46%), Gaps = 19/255 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGD-----YRGNKVAVKCIKNDATAQ------AFLAEAS 238 + + +LL+ +GKG +G V G A+K +K + AE + Sbjct: 2 IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERN 61 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 ++ +++H +V L+ + G LY++ EY++ G L +++ + D + ++ Sbjct: 62 ILEEVKHPFIVDLI-YAFQTGGKLYLILEYLSGGEL--FMQLEREGIFMEDTACFYLAEI 118 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAP 355 A+ +L ++RDL N++++ K++DFGL KE+ + T +++ AP Sbjct: 119 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAP 178 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E L + D WS G L++++ + G P+ K + ++ K K++ P Sbjct: 179 EILMRSGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILKC-KLNLPPYLTQEA 236 Query: 416 YDVMKNCWHLDAATR 430 D++K +AA+R Sbjct: 237 RDLLKKLLKRNAASR 251 >2I0E-A nrPDB Length = 353 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 112/267 (41%), Gaps = 16/267 (5%) Query: 176 TVAAQDEFYRSGWA--LNMKELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDATAQ 231 T +F +G + + + L +GKG FG VML + +G AVK +K D Q Sbjct: 1 TTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ 60 Query: 232 A-----FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVL 286 + E V+ + L + LY V EY+ G L+ +++ GR Sbjct: 61 DDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--F 118 Query: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQ 343 + ++ ++ + +L+ ++RDL NV++ + K++DFG+ KE T Sbjct: 119 KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT 178 Query: 344 DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY 403 T + APE + + + D W+FG+LL+E+ + G+ P+ ++ + + + Sbjct: 179 KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-H 236 Query: 404 KMDAPDGCPPAVYDVMKNCWHLDAATR 430 + P + K R Sbjct: 237 NVAYPKSMSKEAVAICKGLMTKHPGKR 263 >5HVK-A nrPDB Length = 315 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 83/281 (29%), Positives = 128/281 (45%), Gaps = 28/281 (9%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI--KNDATAQAFLAEASVMTQLRH 245 +L + +GKG FG + +R G + +K + ++ T + FL E VM L H Sbjct: 11 FRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEH 70 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+++ +GV+ ++K L +TEY+ G+L ++S S + F+ D+ M YL Sbjct: 71 PNVLKFIGVLYKDK-RLNFITEYIKGGTLRGIIKSM-DSQYPWSQRVSFAKDIASGMAYL 128 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----------------TGKL 348 N +HR+L + N LV E+ V+DFGL + + T Sbjct: 129 HSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVG 188 Query: 349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV---PYPRIPLKDVVPRVEKGYKM 405 W APE + + + K DV+SFGI+L EI GRV P D V Sbjct: 189 NPYWMAPEMINGRSYDEKVDVFSFGIVLCEII--GRVNADPDYLPRTMDFGLNVRGFLDR 246 Query: 406 DAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTH 446 P CPP+ + + C LD RP+F++L LE +R H Sbjct: 247 YCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMH 287 >5D7A-A nrPDB Length = 308 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 117/280 (41%), Gaps = 19/280 (6%) Query: 178 AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK-NDATAQAFL 234 + DE S +L++ +G G +G V G + G A+K + + Sbjct: 2 SGADEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK 61 Query: 235 AEASVMTQL-RHSNLVQLLGVIVEE-----KGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 E +++ + H N+ G +++ L++V E+ GS+ D +++ + L Sbjct: 62 QEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKE 121 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDT 345 + + ++ + +L + +HRD+ +NVL++E+ K+ DFG++ + T ++T Sbjct: 122 EWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNT 181 Query: 346 GKLPVKWTAPEALR-----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE 400 W APE + + + KSD+WS GI E+ + G P + + + Sbjct: 182 FIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEM-AEGAPPLCDMHPMRALFLIP 240 Query: 401 KGYKMDA-PDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + +++C + + RP QL + Sbjct: 241 RNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKH 280 >5F9E-A nrPDB Length = 353 Score = 224 bits (572), Expect = 5e-59, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 117/269 (43%), Gaps = 20/269 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDA-----TAQAFLAEASVMTQ 242 L +++ +L + +GKG FG V L +++ A+K +K D + + E V++ Sbjct: 16 LKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL 75 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + + + K L+ V EY+ G L+ +++S + ++ ++ + Sbjct: 76 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK--FDLSRATFYAAEIILGL 133 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQDTGKLPVKWTAPEALR 359 ++L V+RDL N+L+ +D K++DFG+ KE + + + APE L Sbjct: 134 QFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 +K++ D WSFG+LL+E+ G+ P+ +++ + P D++ Sbjct: 194 GQKYNHSVDWWSFGVLLYEML-IGQSPFHGQDEEELFHSIRMDNPFY-PRWLEKEAKDLL 251 Query: 420 KNCWHLDAATRPTFLQLREQLEHIRTHEL 448 + + R IR H L Sbjct: 252 VKLFVREPEKRLGVRG------DIRQHPL 274 >6HXF-B nrPDB Length = 302 Score = 223 bits (570), Expect = 8e-59, Method: Composition-based stats. Identities = 63/259 (24%), Positives = 115/259 (44%), Gaps = 17/259 (6%) Query: 195 LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI--KNDATAQAFLAEASVMTQLRHSNLVQ 250 +++ +G G FG V + G A K I K++ + ++ E ++ H +V+ Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVK 80 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 LLG + G L+I+ E+ G++ D + L + + EA+ +L Sbjct: 81 LLGAYYHD-GKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRI 138 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAPEA-----LREKK 362 +HRDL A NVL++ + +++DFG++ + T +D+ W APE +++ Sbjct: 139 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 198 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA--PDGCPPAVYDVMK 420 + K+D+WS GI L E+ P+ + V+ ++ K P D +K Sbjct: 199 YDYKADIWSLGITLIEMAQI-EPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 257 Query: 421 NCWHLDAATRPTFLQLREQ 439 + TRP+ QL E Sbjct: 258 IALDKNPETRPSAAQLLEH 276 >4WNO-A nrPDB Length = 287 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 69/269 (25%), Positives = 113/269 (42%), Gaps = 28/269 (10%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN---KVAVKCIKND--ATAQAFL-AEASV 239 + + K+L IG G F V G +R +VAVKCI A +Q L E + Sbjct: 16 GKFEFSRKDL-----IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKI 70 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 + +L+H N+V L E +Y+V EY G L DYL + L D + F + Sbjct: 71 LKELKHENIVALYD-FQEMANSVYLVMEYCNGGDLADYLHAMR--TLSEDTIRLFLQQIA 127 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDN---------VAKVSDFGLTKEASSTQD--TGKL 348 AM L +HRDL +N+L+S K++DFG + S T Sbjct: 128 GAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCG 187 Query: 349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM--D 406 + APE + + + K+D+WS G ++++ + G+ P+ +D+ EK + Sbjct: 188 SPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLT-GKAPFQASSPQDLRLFYEKNKTLVPT 246 Query: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQ 435 P + ++ + R F + Sbjct: 247 IPRETSAPLRQLLLALLQRNHKDRMDFDE 275 >3NIZ-A nrPDB Length = 311 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 120/286 (41%), Gaps = 42/286 (14%) Query: 192 MKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQAF----LAEASVMTQLRHS 246 M++ + L+ +G+G +G V +G VA+K I+ DA + + E S++ +L H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHP 79 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V L+ VI E+ L +V E+M K L L ++ L + + + + + Sbjct: 80 NIVSLIDVIHSER-CLTLVFEFMEK-DLKKVL-DENKTGLQDSQIKIYLYQLLRGVAHCH 136 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALRE-KK 362 + +HRDL +N+L++ D K++DFGL + + + + + AP+ L KK Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPP--------- 413 +ST D+WS G + E+ + G+ +P + D +P++ P P Sbjct: 197 YSTSVDIWSIGCIFAEMIT-GKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQ 255 Query: 414 --------------------AVYDVMKNCWHLDAATRPTFLQLREQ 439 D++ N D R + Sbjct: 256 RTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNH 301 >4FIE-A nrPDB Length = 423 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 58/258 (22%), Positives = 108/258 (41%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKC--IKNDATAQAFLAEASVMTQLRHS 246 L IG+G G V + R G VAVK ++ + E +M +H Sbjct: 149 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 208 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V++ + L++V E++ G+L D + + + + + L V +A+ L Sbjct: 209 NVVEMYNSYL-VGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLH 264 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALREKKF 363 +HRD+ + ++L++ D K+SDFG + S + + W APE + + Sbjct: 265 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 324 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY--KMDAPDGCPPAVYDVMKN 421 + D+WS GI++ E+ G PY P + + ++ P++ + Sbjct: 325 GPEVDIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDR 383 Query: 422 CWHLDAATRPTFLQLREQ 439 D A R T +L + Sbjct: 384 LLVRDPAQRATAAELLKH 401 >2F57-A nrPDB Length = 317 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 59/258 (22%), Positives = 105/258 (40%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKC--IKNDATAQAFLAEASVMTQLRHS 246 + L IG+G G V + + G +VAVK ++ + E +M H Sbjct: 43 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 102 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V + + L++V E++ G+L D + + + + + L V A+ YL Sbjct: 103 NVVDMYSSYL-VGDELWVVMEFLEGGALTDIV---THTRMNEEQIATVCLSVLRALSYLH 158 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEALREKKF 363 +HRD+ + ++L++ D K+SDFG + S K W APE + + Sbjct: 159 NQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY 218 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD--GCPPAVYDVMKN 421 T+ D+WS GI++ E+ G PY P + R+ D + + Sbjct: 219 GTEVDIWSLGIMVIEMI-DGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDL 277 Query: 422 CWHLDAATRPTFLQLREQ 439 + + R T +L Sbjct: 278 MLVREPSQRATAQELLGH 295 >5J5T-A nrPDB Length = 370 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 58/262 (22%), Positives = 110/262 (41%), Gaps = 16/262 (6%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQ--AFLAEASVMTQLRHS 246 + ++ +L+Q IG G +GDV G A+K IK + E +M +H Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHP 61 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V G + + L+I E+ GSL D G L + S + + + YL Sbjct: 62 NIVAYFGSYLR-RDKLWICMEFCGGGSLQDIYHVTG--PLSELQIAYVSRETLQGLYYLH 118 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEAL---RE 360 +HRD+ N+L++++ K++DFG++ + ++T K W APE R+ Sbjct: 119 SKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERK 178 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG---CPPAVYD 417 ++ D+W+ GI E+ + P++ + + ++ + + Sbjct: 179 GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHH 238 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 +K + RPT +L + Sbjct: 239 FVKMALTKNPKKRPTAEKLLQH 260 >6QAU-A nrPDB Length = 280 Score = 222 bits (565), Expect = 4e-58, Method: Composition-based stats. Identities = 61/239 (25%), Positives = 104/239 (43%), Gaps = 23/239 (9%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGN---KVAVKCIKNDATAQAFL---AEASVMTQLRHSN 247 E +G G F V G +R +VA+K I +++ + E ++ +L+H N Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHEN 71 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +V L V E +++V EY G L DYL+++G L D + F + AM L Sbjct: 72 IVALYDV-QELPNSVFLVMEYCNGGDLADYLQAKG--TLSEDTIRVFLHQIAAAMRILHS 128 Query: 308 NNFVHRDLAARNVLVS---------EDNVAKVSDFGLTKEASSTQDTG--KLPVKWTAPE 356 +HRDL +N+L+S K++DFG + S + APE Sbjct: 129 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPE 188 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM--DAPDGCPP 413 + + + K+D+WS G ++++ G+ P+ +D+ EK + P P Sbjct: 189 VIMSQHYDAKADLWSIGTVIYQCL-VGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSP 246 >3DB8-A nrPDB Length = 317 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 104/257 (40%), Gaps = 15/257 (5%) Query: 191 NMKELKLLQTIGKGEFGDVML--GDYRGNKVAVKCIKND-----ATAQAFLAEASVMTQL 243 MK + +GKG F A K + + E ++ L Sbjct: 40 TMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSL 99 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 + ++V G E+ +Y+V E + SL++ + R + F + ++ Sbjct: 100 DNPHVVGFHG-FFEDDDFVYVVLEICRRRSLLELHKRRK--AVTEPEARYFMRQTIQGVQ 156 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALRE 360 YL N +HRDL N+ +++D K+ DFGL + + + APE L + Sbjct: 157 YLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK 216 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 K S + D+WS G +L+ + G+ P+ LK+ R++K + P P +++ Sbjct: 217 KGHSFEVDIWSLGCILYTLL-VGKPPFETSCLKETYIRIKKN-EYSVPRHINPVASALIR 274 Query: 421 NCWHLDAATRPTFLQLR 437 H D RP+ +L Sbjct: 275 RMLHADPTLRPSVAELL 291 >5JZN-A nrPDB Length = 280 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 112/276 (40%), Gaps = 21/276 (7%) Query: 181 DEFYRSGWALNM---KELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDA---TAQA 232 +E G+ + + K+ +TIG G F V + A+K IK Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM 63 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 E S++ +++H N+V L+ ++ LY+V E + G L D + S + Sbjct: 64 IQNEVSILRRVKHPNIVLLIEE-MDVPTELYLVMELVKGGDLFDAITSTNK--YTERDAS 120 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLV----SEDNVAKVSDFGLTKEASSTQDTGKL 348 ++ A++YL N VHRD+ N+LV K+ DFGL T Sbjct: 121 GMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCG 180 Query: 349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPY--PRIPLKDVVPRVEKGY-KM 405 + APE + E + K D+W+ G++ + + G P+ + + ++ G Sbjct: 181 TPTYVAPEIIAETGYGLKVDIWAAGVITYILLC-GFPPFRGSGDDQEVLFDQILMGQVDF 239 Query: 406 DAP--DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 +P D + +++ +D R + +Q+ E Sbjct: 240 PSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEH 275 >6BDL-A nrPDB Length = 347 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 111/269 (41%), Gaps = 17/269 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK---VAVKCIKND-----ATAQAFLAEASVMT 241 L + + ++ T+G G FG V L + + A+K +K + +E +M Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 90 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +V+L ++ LY++ E G L LR RG ++ V EA Sbjct: 91 GAHSDFIVRLYRTF-KDSKYLYMLMEACLGGELWTILRDRGS--FEDSTTRFYTACVVEA 147 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALR 359 YL ++RDL N+++ AK+ DFG K+ + T ++ APE + Sbjct: 148 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIIL 207 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM-DAPDGCPPAVYDV 418 K +D WS GIL++E+ + G P+ + +G M + P ++ Sbjct: 208 NKGHDISADYWSLGILMYELLT-GSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANL 266 Query: 419 MKNCWHLDAATRPTFLQLREQLEHIRTHE 447 +K + + R L+ ++ I+ H+ Sbjct: 267 IKKLCRDNPSERL--GNLKNGVKDIQKHK 293 >3ORZ-A nrPDB Length = 316 Score = 221 bits (563), Expect = 5e-58, Method: Composition-based stats. Identities = 62/256 (24%), Positives = 115/256 (44%), Gaps = 17/256 (6%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQA-----FLAEASVMTQLRH 245 ++ K + +G+G F V+L + A+K ++ + E VM++L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 V+L ++ LY Y G L+ Y+R G C ++ ++ A+EYL Sbjct: 97 PFFVKLY-FCFQDDEKLYFGLSYAKNGELLKYIRKIGS--FDETCTRFYTAEIVSALEYL 153 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALRE 360 G +HRDL N+L++ED +++DFG K S + ++ +PE L E Sbjct: 154 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 213 Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMK 420 K SD+W+ G +++++ + G P+ + ++ K + D P+ P D+++ Sbjct: 214 KSACKSSDLWALGCIIYQLVA-GLPPFRAGNEYLIFQKIIK-LEYDFPEKFFPKARDLVE 271 Query: 421 NCWHLDAATRPTFLQL 436 LDA R ++ Sbjct: 272 KLLVLDATKRLGCEEM 287 >4JDH-A nrPDB Length = 346 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 58/258 (22%), Positives = 108/258 (41%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKC--IKNDATAQAFLAEASVMTQLRHS 246 L IG+G G V + R G VAVK ++ + E +M +H Sbjct: 72 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 131 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V++ + L++V E++ G+L D + + + + + L V +A+ L Sbjct: 132 NVVEMYNSYL-VGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLH 187 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALREKKF 363 +HRD+ + ++L++ D K+SDFG + S + + W APE + + Sbjct: 188 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 247 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY--KMDAPDGCPPAVYDVMKN 421 + D+WS GI++ E+ G PY P + + ++ P++ + Sbjct: 248 GPEVDIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDR 306 Query: 422 CWHLDAATRPTFLQLREQ 439 D A R T +L + Sbjct: 307 LLVRDPAQRATAAELLKH 324 >2Q0N-A nrPDB Length = 301 Score = 220 bits (562), Expect = 7e-58, Method: Composition-based stats. Identities = 58/258 (22%), Positives = 108/258 (41%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKC--IKNDATAQAFLAEASVMTQLRHS 246 L IG+G G V + R G VAVK ++ + E +M +H Sbjct: 27 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 86 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V++ + L++V E++ G+L D + + + + + L V +A+ L Sbjct: 87 NVVEMYNSYL-VGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLH 142 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALREKKF 363 +HRD+ + ++L++ D K+SDFG + S + + W APE + + Sbjct: 143 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 202 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY--KMDAPDGCPPAVYDVMKN 421 + D+WS GI++ E+ G PY P + + ++ P++ + Sbjct: 203 GPEVDIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDR 261 Query: 422 CWHLDAATRPTFLQLREQ 439 D A R T +L + Sbjct: 262 LLVRDPAQRATAAELLKH 279 >3IS5-A nrPDB Length = 285 Score = 220 bits (562), Expect = 8e-58, Method: Composition-based stats. Identities = 65/260 (25%), Positives = 116/260 (44%), Gaps = 19/260 (7%) Query: 195 LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA---QAFLAEASVMTQLRHSNLV 249 + +G G FGDV L + R G + +K I D + + AE V+ L H N++ Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPNII 83 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV--LGGDCLLKFSLDVCEAMEYLEG 307 ++ V E+ +YIV E G L++ + S L + + + A+ Y Sbjct: 84 KIFEVF-EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHS 142 Query: 308 NNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKK 362 + VH+DL N+L + + K+ DFGL + S + + APE + + Sbjct: 143 QHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFK-RD 201 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV---EKGYKMDAPDGCPPAVYDVM 419 + K D+WS G++++ + + G +P+ L++V + E Y ++ P AV D++ Sbjct: 202 VTFKCDIWSAGVVMYFLLT-GCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAV-DLL 259 Query: 420 KNCWHLDAATRPTFLQLREQ 439 K D RP+ Q+ Sbjct: 260 KQMLTKDPERRPSAAQVLHH 279 >4NEU-A nrPDB Length = 333 Score = 220 bits (562), Expect = 8e-58, Method: Composition-based stats. Identities = 85/284 (29%), Positives = 133/284 (46%), Gaps = 31/284 (10%) Query: 189 ALNMKELKLLQ--TIGKGEFGDVMLGDYRGNKVAV-KCIKNDATA----QAFLAEASVMT 241 + MK L+ + G FG V L +R + + K + +A L EA +M Sbjct: 18 VIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMN 77 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +LRHS +V+LLGVI+EE G +V EYM KG+L+ L++ + L + L++ E Sbjct: 78 RLRHSRVVKLLGVIIEE-GKYSLVMEYMEKGNLMHVLKAEMSTPLSVKG--RIILEIIEG 134 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT----------------KEASSTQDT 345 M YL G +H+DL N+LV D K++D GL +E T Sbjct: 135 MCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKK 194 Query: 346 GKLPVKWTAPEALRE--KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY 403 + + APE L + K + KSDV+SF ++LW I++ I + ++ ++ G Sbjct: 195 NGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGN 254 Query: 404 KMDAPD---GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 + D D CP + +MK CW + RPTF + E+ Sbjct: 255 RPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFY 298 >4XBR-A nrPDB Length = 366 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 58/258 (22%), Positives = 108/258 (41%), Gaps = 14/258 (5%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKC--IKNDATAQAFLAEASVMTQLRHS 246 L IG+G G V + R G VAVK ++ + E +M +H Sbjct: 92 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 151 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V++ + L++V E++ G+L D + + + + + L V +A+ L Sbjct: 152 NVVEMYNSYL-VGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLH 207 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALREKKF 363 +HRD+ + ++L++ D K+SDFG + S + + W APE + + Sbjct: 208 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 267 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY--KMDAPDGCPPAVYDVMKN 421 + D+WS GI++ E+ G PY P + + ++ P++ + Sbjct: 268 GPEVDIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDR 326 Query: 422 CWHLDAATRPTFLQLREQ 439 D A R T +L + Sbjct: 327 LLVRDPAQRATAAELLKH 344 >3C51-A nrPDB Length = 543 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 71/318 (22%), Positives = 126/318 (39%), Gaps = 34/318 (10%) Query: 160 ADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQ-------------TIGKGEF 206 DGL L++ + A EF S + L + K L+ +G+G F Sbjct: 139 GDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGF 198 Query: 207 GDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQLRHSNLVQLLGVIVEEK 259 G+V + G A K + Q + E ++ ++ +V L E K Sbjct: 199 GEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL-AYAFETK 257 Query: 260 GGLYIVTEYMAKGSLVDYLRS--RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAA 317 L +V M G + ++ + + ++ + +E+L N ++RDL Sbjct: 258 TDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKP 317 Query: 318 RNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEALREKKFSTKSDVWSFGI 374 NVL+ +D ++SD GL E + Q K + APE L +++ D ++ G+ Sbjct: 318 ENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGV 377 Query: 375 LLWEIYSFGRVPY----PRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 L+E+ + R P+ ++ K++ RV + + PD PA D + D R Sbjct: 378 TLYEMIAA-RGPFRARGEKVENKELKQRVLE-QAVTYPDKFSPASKDFCEALLQKDPEKR 435 Query: 431 PTFLQLREQLEHIRTHEL 448 F + +RTH L Sbjct: 436 LGFRD--GSCDGLRTHPL 451 >5LOH-A nrPDB Length = 341 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 111/266 (41%), Gaps = 22/266 (8%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK-----NDATAQAFLAEASVMTQLRH 245 +++E +++ I +G FG V LG G AVK +K N AE + + Sbjct: 34 SIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 +V L ++ +Y+V EY+ G + L G + +K+ +V A++YL Sbjct: 94 PFIVHLY-YSLQSANNVYLVMEYLIGGDVKSLLHIYG--YFDEEMAVKYISEVALALDYL 150 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---------TQDTGKLPVKWTAPE 356 + +HRDL N+L+S + K++DFGL+K + T T + APE Sbjct: 151 HRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPE 210 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG---CPP 413 L + D W+ G+ L+E + G P+ + V + K + P+G Sbjct: 211 LLLGRAHGPAVDWWALGVCLFEFLT-GIPPFNDETPQQVFQNILK-RDIPWPEGEEKLSD 268 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQ 439 ++ +D R +L+ Sbjct: 269 NAQSAVEILLTIDDTKRAGMKELKRH 294 >4BBM-A nrPDB Length = 331 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 120/303 (39%), Gaps = 44/303 (14%) Query: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI----KNDATA 230 + D + + +M++ + L +G+G +G VM + G VA+K + Sbjct: 9 SSGVDLGTENLYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVK 68 Query: 231 QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC 290 + + E ++ QLRH NLV LL V ++K Y+V E++ L D + L Sbjct: 69 KIAMREIKLLKQLRHENLVNLLEVC-KKKKRWYLVFEFVDHTILDDL--ELFPNGLDYQV 125 Query: 291 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTGK 347 + K+ + + + +N +HRD+ N+LVS+ V K+ DFG + ++ D Sbjct: 126 VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEV 185 Query: 348 LPVKWTAPEALREK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE------ 400 + APE L K+ DVW+ G L+ E++ G +P D + + Sbjct: 186 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMF-MGEPLFPGDSDIDQLYHIMMCLGNL 244 Query: 401 --------------KGYKMDAP----------DGCPPAVYDVMKNCWHLDAATRPTFLQL 436 G ++ V D+ K C H+D RP +L Sbjct: 245 IPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAEL 304 Query: 437 REQ 439 Sbjct: 305 LHH 307 >4I6B-A nrPDB Length = 308 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 55/257 (21%), Positives = 100/257 (38%), Gaps = 15/257 (5%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK-----NDATAQAFLAEASVMTQLRH 245 K +T+GKG F A K I + E + L H Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 ++VQ E+K +YI+ EY ++ S+ L++R VL + + + ++YL Sbjct: 88 KHVVQFYHYF-EDKENIYILLEYCSRRSMAHILKARK--VLTEPEVRYYLRQIVSGLKYL 144 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---TQDTGKLPVKWTAPEALREKK 362 +HRDL N ++E KV DFGL + T + +PE L ++ Sbjct: 145 HEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQG 204 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNC 422 +SD+W+ G +++ + GR P+ LK+ + + + P ++ + Sbjct: 205 HGAESDIWALGCVMYTML-LGRPPFETTNLKETYRSIRE-ARYTMPSSLLAPAKHLIASM 262 Query: 423 WHLDAATRPTFLQLREQ 439 + RP+ + Sbjct: 263 LSKNPEDRPSLDDIIRH 279 >5FET-A nrPDB Length = 847 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 61/267 (22%), Positives = 112/267 (41%), Gaps = 17/267 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDA-----TAQAFLAEASVMTQ 242 + M EL+ + IG+G FG V L ++ + A+KC+ + E + + Sbjct: 530 VEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAE 589 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 H +++L+ ++ Y +TE + G L D +R G +L + + A+ Sbjct: 590 NDHPFIIRLVRTF-KDSNCFYFLTELVTGGELYDAIRKLG--LLSKPQAQFYLGSIILAI 646 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKK 362 EYL N V+RDL N+L+ + K+ DFG K+ T + APE + K Sbjct: 647 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGKG 706 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPY--PRIPLKDVVPRVEKGYKMDAPDGCPP-AVYDVM 419 + D+W+ G+ L+E + G +P+ + ++ + G ++ PD ++M Sbjct: 707 YGCTVDIWALGVCLYE-FICGPLPFGNDQEDQLEIFRDILTG-QLTFPDYVSDQDSINLM 764 Query: 420 KNCWHLDAATRPTFLQLREQLEHIRTH 446 K R + I+ H Sbjct: 765 KRLLCRLPQGRIGCS--INGFKDIKEH 789 >5WAX-A nrPDB Length = 310 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 69/260 (26%), Positives = 106/260 (40%), Gaps = 17/260 (6%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKN-DATAQAFLAEASVMTQLRHSNLV 249 +L++ IG G FG L R G VAVK I+ + + E LRH N++ Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRHPNII 70 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 + VI+ L IV EY + G L + + + GR D F + + Y Sbjct: 71 RFKEVILT-PTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHSMQ 127 Query: 310 FVHRDLAARNVLVSEDN--VAKVSDFGLTKE--ASSTQDTGKLPVKWTAPEALREKKFST 365 HRDL N L+ K+ DFG +K S + + APE L +K++ Sbjct: 128 VCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 187 Query: 366 KS-DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---GYKMDAPD--GCPPAVYDVM 419 K DVWS G+ L+ + G P+ + + G + PD P D++ Sbjct: 188 KVADVWSCGVTLYVML-VGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQDLI 246 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + + ATR T ++R Sbjct: 247 SRIFVANPATRITIPEIRNH 266 >2XNP-A nrPDB Length = 279 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 59/263 (22%), Positives = 115/263 (43%), Gaps = 18/263 (6%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRHS 246 ++ ++L TIG G +G + G + K + +A Q ++E +++ +L+H Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 247 NLVQLLG-VIVEEKGGLYIVTEYMAKGSLVDYLRS--RGRSVLGGDCLLKFSLDVCEAME 303 N+V+ +I LYIV EY G L + + R L + +L+ + A++ Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125 Query: 304 YLEG-----NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAP 355 + +HRDL NV + K+ DFGL + + K + +P Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV 415 E + ++ KSD+WS G LL+E+ + P+ K++ ++ +G P + Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCAL-MPPFTAFSQKELAGKIREGKFRRIPYRYSDEL 244 Query: 416 YDVMKNCWHLDAATRPTFLQLRE 438 +++ +L RP+ ++ E Sbjct: 245 NEIITRMLNLKDYHRPSVEEILE 267 >4B6L-A nrPDB Length = 281 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 97/255 (38%), Gaps = 15/255 (5%) Query: 195 LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK-----NDATAQAFLAEASVMTQLRHSN 247 + +GKG F G+ AVK I + L E + L+H + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +V+ E+ +YI E ++ SL ++R L + + + ++YL Sbjct: 71 IVRFSHHF-EDADNIYIFLELCSRKSLAHIWKAR--HTLLEPEVRYYLRQILSGLKYLHQ 127 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD---TGKLPVKWTAPEALREKKFS 364 +HRDL N ++E+ KV DFGL + T + APE L + Sbjct: 128 RGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHG 187 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWH 424 ++DVWS G +++ + G P+ LK+ +++ + P ++ Sbjct: 188 PEADVWSLGCVMYTLLC-GSPPFETADLKETYRCIKQVH-YTLPASLSLPARQLLAAILR 245 Query: 425 LDAATRPTFLQLREQ 439 RP+ Q+ Sbjct: 246 ASPRDRPSIDQILRH 260 >4PDS-A nrPDB Length = 347 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 117/274 (42%), Gaps = 30/274 (10%) Query: 192 MKELKLL-QTIGKGEFGDVMLG--DYRGNKVAVKCIKNDAT---AQAFLAEASVMTQLRH 245 K+ ++ + +G+G F V G +VK I E V+ +L H Sbjct: 29 FKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNH 88 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 +V+L G E+ Y+V E+++ G L+D++ + G +G D + S + A++Y+ Sbjct: 89 PRIVRLKG-FYEDTESYYMVMEFVSGGDLMDFVAAHG--AVGEDAGREISRQILTAIKYI 145 Query: 306 EGNNFVHRDLAARNVLVSEDN--VAKVSDFGLTKEA--SSTQDTGKLPVKWTAPEALREK 361 HRDL N+L+ +D+ + K++ FGL K S T + + APE +R K Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 205 Query: 362 -------------KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP 408 ++S+ D+WS G L++ I + G +P+ + ++ +G + P Sbjct: 206 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGP 264 Query: 409 ---DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 D + + +D R T + Sbjct: 265 LKDFRISEEARDFIDSLLQVDPNNRSTAAKALNH 298 >5DYK-A nrPDB Length = 853 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 63/268 (23%), Positives = 111/268 (41%), Gaps = 17/268 (6%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDA-----TAQAFLAEASVMTQ 242 + M EL+ + IG+G FG V L ++ K A+KC+ + E + + Sbjct: 536 VEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAE 595 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 H +++L+ ++ Y +TE + G L D +R G +L + + A+ Sbjct: 596 NDHPFIIRLVRTF-KDSKYFYFLTELVTGGELYDAIRKLG--LLSKSQAQFYLGSIILAI 652 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKK 362 EYL N V+RDL N+L+ + K+ DFG K+ T + APE + K Sbjct: 653 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKG 712 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPY--PRIPLKDVVPRVEKGYKMDAPDGCPP-AVYDVM 419 + D+W+ GI L+E + G +P+ ++ + G ++ PD ++M Sbjct: 713 YGCTVDIWALGICLYE-FICGPLPFGNDEEDQLEIFRDILTG-QLTFPDYVTDTDSINLM 770 Query: 420 KNCWHLDAATRPTFLQLREQLEHIRTHE 447 K R + I+ H Sbjct: 771 KRLLCRLPQGRIGCS--INGFKDIKDHP 796 >2OU7-A nrPDB Length = 335 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 59/249 (23%), Positives = 101/249 (40%), Gaps = 15/249 (6%) Query: 201 IGKGEFGDVML--GDYRGNKVAVKCIKND-----ATAQAFLAEASVMTQLRHSNLVQLLG 253 +GKG F A K + + E S+ L H ++V G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 E+ +++V E + SL++ + R L + + +YL N +HR Sbjct: 109 -FFEDNDFVFVVLELCRRRSLLELHKRRK--ALTEPEARYYLRQIVLGCQYLHRNRVIHR 165 Query: 314 DLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAPEALREKKFSTKSDVW 370 DL N+ ++ED K+ DFGL + + K+ + APE L +K S + DVW Sbjct: 166 DLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVW 225 Query: 371 SFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 S G +++ + G+ P+ LK+ R++K + P P +++ D R Sbjct: 226 SIGCIMYTLL-VGKPPFETSCLKETYLRIKKN-EYSIPKHINPVAASLIQKMLQTDPTAR 283 Query: 431 PTFLQLREQ 439 PT +L Sbjct: 284 PTINELLND 292 >2W4O-A nrPDB Length = 349 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 113/284 (39%), Gaps = 15/284 (5%) Query: 168 IKPKVMEGTVAAQDEFYRSGWALNM--KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKC 223 + GT + +++ G + ++ +G+G V +G + A+K Sbjct: 26 VTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKV 85 Query: 224 IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR 283 +K + E V+ +L H N+++L + E + +V E + G L D + +G Sbjct: 86 LKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIF-ETPTEISLVLELVTGGELFDRIVEKG- 143 Query: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTK--E 338 + EA+ YL N VHRDL N+L + D K++DFGL+K E Sbjct: 144 -YYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE 202 Query: 339 ASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 T + APE LR + + D+WS GI+ + + Y + + R Sbjct: 203 HQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRR 262 Query: 399 VEK-GYKMDAP--DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + Y +P D D+++ LD R T Q + Sbjct: 263 ILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQH 306 >4AGU-A nrPDB Length = 311 Score = 218 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 120/298 (40%), Gaps = 46/298 (15%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT----AQAFLAEASVMTQLRH 245 M++ + + IG+G +G V R G VA+K + L E ++ QL+H Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 NLV LL V K L++V EY L + R + + + + +A+ + Sbjct: 62 PNLVNLLEVF-RRKRRLHLVFEYCDHTVLHEL--DRYQRGVPEHLVKSITWQTLQAVNFC 118 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTGKLPVKWTAPEAL-REK 361 +N +HRD+ N+L+++ +V K+ DFG + + D + +PE L + Sbjct: 119 HKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-------------------- 401 ++ DVW+ G + E+ S G +P D + + K Sbjct: 179 QYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFS 237 Query: 402 GYKMDAPDGCPP----------AVYDVMKNCWHLDAATRPTFLQLREQ--LEHIRTHE 447 G K+ P+ P ++K C H+D R T QL E+IR E Sbjct: 238 GVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIE 295 >3F3Z-A nrPDB Length = 277 Score = 217 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 104/260 (40%), Gaps = 19/260 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIKN--DATAQAFLAEASVMTQLRHSNL 248 + L TIG+G +G+V + +G ++ A K I F E +M L H N+ Sbjct: 9 QYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLDHPNI 68 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 ++L E+ +Y+V E G L + + + V + DV A+ Y Sbjct: 69 IRLYETF-EDNTDIYLVMELCTGGELFERVVHKR--VFRESDAARIMKDVLSAVAYCHKL 125 Query: 309 NFVHRDLAARNVLV---SEDNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALREKKF 363 N HRDL N L S D+ K+ DFGL + T + +P+ L + Sbjct: 126 NVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEGL-Y 184 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD----GCPPAVYDVM 419 + D WS G++++ + G P+ +V+ ++ +G P+ P ++ Sbjct: 185 GPECDEWSAGVMMYVLLC-GYPPFSAPTDSEVMLKIREG-TFTFPEKDWLNVSPQAESLI 242 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + R T LQ E Sbjct: 243 RRLLTKSPKQRITSLQALEH 262 >4F0G-A nrPDB Length = 287 Score = 217 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 74/274 (27%), Positives = 133/274 (48%), Gaps = 28/274 (10%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCI---------KNDATAQAFLAEASVMT 241 E++ + IGKG FG V G +K VA+K + + Q F E +M+ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 L H N+V+L G++ +V E++ G L L + + L+ LD+ Sbjct: 79 NLNHPNIVKLYGLMHNPPR---MVMEFVPCGDLYHRLLDKAH-PIKWSVKLRLMLDIALG 134 Query: 302 MEYLEGNN--FVHRDLAARNVLV---SEDNVA--KVSDFGLTKEASSTQDTGKLPVKWTA 354 +EY++ N VHRDL + N+ + E+ KV+DFGL++++ + +W A Sbjct: 135 IEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMA 194 Query: 355 PEAL--REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV--VPRV-EKGYKMDAPD 409 PE + E+ ++ K+D +SF ++L+ I + G P+ + + + E+G + P+ Sbjct: 195 PETIGAEEESYTEKADTYSFAMILYTILT-GEGPFDEYSYGKIKFINMIREEGLRPTIPE 253 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 CPP + +V++ CW D RP F + ++L + Sbjct: 254 DCPPRLRNVIELCWSGDPKKRPHFSYIVKELSEL 287 >4AF3-A nrPDB Length = 292 Score = 217 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 60/277 (21%), Positives = 115/277 (41%), Gaps = 16/277 (5%) Query: 171 KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKC----- 223 KVME + D R + + ++ + +GKG+FG+V L + + VA+K Sbjct: 4 KVMENSSGTPDILTRH---FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ 60 Query: 224 IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR 283 I+ + E + L H N+++L ++ +Y++ EY +G L L + Sbjct: 61 IEKEGVEHQLRREIEIQAHLHHPNILRLYNYFY-DRRRIYLILEYAPRGELYKEL--QKS 117 Query: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 343 ++ +A+ Y G +HRD+ N+L+ K++DFG + A S + Sbjct: 118 CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLR 177 Query: 344 D-TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG 402 T + + PE + + + K D+W G+L +E+ G P+ + R+ K Sbjct: 178 RKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELL-VGNPPFESASHNETYRRIVK- 235 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + P P D++ + + R Q+ Sbjct: 236 VDLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAH 272 >1VZO-A nrPDB Length = 355 Score = 217 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 117/281 (41%), Gaps = 30/281 (10%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVML-----GDYRGNKVAVKCIKND------ATAQAFL 234 + ++ +LL+ +G G +G V L G G A+K +K T + Sbjct: 47 HAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTR 106 Query: 235 AEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 E V+ +R S + L + + L+++ +Y+ G L +L R R + + Sbjct: 107 TERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER--FTEHEVQIY 164 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPV 350 ++ A+E+L ++RD+ N+L+ + ++DFGL+KE + + + Sbjct: 165 VGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTI 224 Query: 351 KWTAPEALREK--KFSTKSDVWSFGILLWEIYSFGRVPY----PRIPLKDVVPRVEKGYK 404 ++ AP+ +R D WS G+L++E+ + G P+ + ++ R+ K + Sbjct: 225 EYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLT-GASPFTVDGEKNSQAEISRRILKS-E 282 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRP-----TFLQLREQL 440 P D+++ D R +++E L Sbjct: 283 PPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHL 323 >4B8L-A nrPDB Length = 286 Score = 217 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 106/258 (41%), Gaps = 13/258 (5%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCI-----KNDATAQAFLAEASVMTQ 242 + + + + +GKG+FG+V L + NK A+K + + + E + + Sbjct: 12 FTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSH 71 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 LRH N++++ ++ +Y++ E+ +G L L+ GR F ++ +A+ Sbjct: 72 LRHPNILRMYNYF-HDRKRIYLMLEFAPRGELYKELQKHGR--FDEQRSATFMEELADAL 128 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-TQDTGKLPVKWTAPEALREK 361 Y +HRD+ N+L+ K++DFG + A S + T + + PE + K Sbjct: 129 HYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGK 188 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 K D+W G+L +E + G P+ + R+ + P D++ Sbjct: 189 THDEKVDLWCAGVLCYE-FLVGMPPFDSPSHTETHRRIVN-VDLKFPPFLSDGSKDLISK 246 Query: 422 CWHLDAATRPTFLQLREQ 439 R + E Sbjct: 247 LLRYHPPQRLPLKGVMEH 264 >6CQF-A nrPDB Length = 297 Score = 217 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 62/276 (22%), Positives = 111/276 (40%), Gaps = 20/276 (7%) Query: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK--NDATAQA 232 V D F R LLQ +G G +G+V + G+ VA+K +K D Sbjct: 4 VVDPDIFNRD----PRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVST 59 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 E ++ RH+N+V G + + L+I E+ GSL D + G L + Sbjct: 60 LQKEILILKTCRHANIVAYHGSYLWLQ-KLWICMEFCGAGSLQDIYQVTGS--LSELQIS 116 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG---KLP 349 +V + + YL +HRD+ N+L+++ +++DFG++ + +T Sbjct: 117 YVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGT 176 Query: 350 VKWTAPE---ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 W APE + ++ D+WS GI E+ + PL+ + + GY+ Sbjct: 177 PYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPP 236 Query: 407 APD---GCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 A ++ +K RP+ ++ Sbjct: 237 RLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >4J52-A nrPDB Length = 293 Score = 217 bits (553), Expect = 8e-57, Method: Composition-based stats. Identities = 59/249 (23%), Positives = 101/249 (40%), Gaps = 15/249 (6%) Query: 201 IGKGEFGDVML--GDYRGNKVAVKCIKND-----ATAQAFLAEASVMTQLRHSNLVQLLG 253 +GKG F A K + + E S+ L H ++V G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 E+ +++V E + SL++ + R L + + +YL N +HR Sbjct: 82 -FFEDNDFVFVVLELCRRRSLLELHKRRK--ALTEPEARYYLRQIVLGCQYLHRNRVIHR 138 Query: 314 DLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL---PVKWTAPEALREKKFSTKSDVW 370 DL N+ ++ED K+ DFGL + + K+ + APE L +K S + DVW Sbjct: 139 DLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVW 198 Query: 371 SFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 S G +++ + G+ P+ LK+ R++K + P P +++ D R Sbjct: 199 SIGCIMYTLL-VGKPPFETSCLKETYLRIKKN-EYSIPKHINPVAASLIQKMLQTDPTAR 256 Query: 431 PTFLQLREQ 439 PT +L Sbjct: 257 PTINELLND 265 >6GU6-A nrPDB Length = 302 Score = 217 bits (553), Expect = 9e-57, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 124/288 (43%), Gaps = 42/288 (14%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ----AFLAEASVMTQLR 244 +M++ ++ IG+G +G V G ++ G VA+K I+ ++ + + E S++ +LR Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 64 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAME 303 H N+V L V++++ LY++ E+++ L YL S + + + + + + Sbjct: 65 HPNIVSLQDVLMQD-SRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEALRE 360 + +HRDL +N+L+ + K++DFGL + + + + +PE L Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 182 Query: 361 K-KFSTKSDVWSFGILLWEIYSFGRVPYPRI---------------PLKDVVPRVE--KG 402 ++ST D+WS G + E+ + + + P +V P VE + Sbjct: 183 SARYSTPVDIWSIGTIFAELATK-KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 241 Query: 403 YKMDAPDGCPPAVY-----------DVMKNCWHLDAATRPTFLQLREQ 439 YK P P ++ D++ D A R + Sbjct: 242 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 289 >4NIF-A nrPDB Length = 333 Score = 217 bits (553), Expect = 9e-57, Method: Composition-based stats. Identities = 62/261 (23%), Positives = 109/261 (41%), Gaps = 22/261 (8%) Query: 195 LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLL 252 + +TIG G + + ++ + AVK I + E ++ +H N++ L Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI-LLRYGQHPNIITLK 68 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 V ++ +Y+VTE M G L+D + + + + +EYL VH Sbjct: 69 DV-YDDGKHVYLVTELMRGGELLDKILRQKF--FSEREASFVLHTIGKTVEYLHSQGVVH 125 Query: 313 RDLAARNVL-VSEDNV---AKVSDFGLTKEASSTQ---DTGKLPVKWTAPEALREKKFST 365 RDL N+L V E ++ DFG K+ + T + APE L+ + + Sbjct: 126 RDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDE 185 Query: 366 KSDVWSFGILLWEIYSFGRVPY---PRIPLKDVVPRVEKGYKMDAPDG----CPPAVYDV 418 D+WS GILL+ + + G P+ P ++++ R+ G K G D+ Sbjct: 186 GCDIWSLGILLYTMLA-GYTPFANGPSDTPEEILTRIGSG-KFTLSGGNWNTVSETAKDL 243 Query: 419 MKNCWHLDAATRPTFLQLREQ 439 + H+D R T Q+ + Sbjct: 244 VSKMLHVDPHQRLTAKQVLQH 264 >4KS7-A nrPDB Length = 292 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 60/249 (24%), Positives = 110/249 (44%), Gaps = 14/249 (5%) Query: 200 TIGKGEFGDVMLGD--YRGNKVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLGVI 255 IG+G G V L + G +VAVK ++ + E +M +H N+V++ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSY 89 Query: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315 + + L+++ E++ G+L D + + L + + V +A+ YL +HRD+ Sbjct: 90 LVGE-ELWVLMEFLQGGALTDIV---SQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDI 145 Query: 316 AARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEALREKKFSTKSDVWSF 372 + ++L++ D K+SDFG + S K W APE + ++T+ D+WS Sbjct: 146 KSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSL 205 Query: 373 GILLWEIYSFGRVPYPRIPLKDVVPRVEKG--YKMDAPDGCPPAVYDVMKNCWHLDAATR 430 GI++ E+ G PY + R+ K+ P + D ++ D R Sbjct: 206 GIMVIEMV-DGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQER 264 Query: 431 PTFLQLREQ 439 T +L + Sbjct: 265 ATAQELLDH 273 >6E2O-A nrPDB Length = 295 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 65/244 (26%), Positives = 111/244 (45%), Gaps = 15/244 (6%) Query: 200 TIGKGEFGDVMLGDYRGNKV--AVKCI--KNDATAQAFLAEASVMTQLRHSNLVQLLGVI 255 +GKG +G V G N+V A+K I ++ +Q E ++ L+H N+VQ LG Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF 88 Query: 256 VEEKGGLYIVTEYMAKGSLVDYLRSR-GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 E G + I E + GSL LRS+ G + ++ + E ++YL N VHRD Sbjct: 89 SEN-GFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 147 Query: 315 LAARNVLVSE-DNVAKVSDFGLTKE---ASSTQDTGKLPVKWTAPEALREKK--FSTKSD 368 + NVL++ V K+SDFG +K + +T +++ APE + + + +D Sbjct: 148 IKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAAD 207 Query: 369 VWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK--MDAPDGCPPAVYDVMKNCWHLD 426 +WS G + E+ + G+ P+ + +K + P+ + C+ D Sbjct: 208 IWSLGCTIIEMAT-GKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPD 266 Query: 427 AATR 430 R Sbjct: 267 PDKR 270 >5UIU-A nrPDB Length = 323 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 79/272 (29%), Positives = 120/272 (44%), Gaps = 33/272 (12%) Query: 200 TIGKGEFGDVMLGDYRGNKVAVKC------IKNDATAQAFLAEASVMTQLRHSNLVQLLG 253 +G+G FG V G VAVK I + Q F E VM + +H NLV+LLG Sbjct: 54 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG 113 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRS-RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 + L +V YM GSL+D L G L K + + +L N+ +H Sbjct: 114 -FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 172 Query: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-----PVKWTAPEALREKKFSTKS 367 RD+ + N+L+ E AK+SDFGL + + T + APEALR + + KS Sbjct: 173 RDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKS 231 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVV---------------PRVEKGYKMDAPDGCP 412 D++SFG++L EI + G ++ ++K KM+ D Sbjct: 232 DIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDK--KMNDADSTS 288 Query: 413 -PAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 A+Y V C H RP ++++ L+ + Sbjct: 289 VEAMYSVASQCLHEKKNKRPDIKKVQQLLQEM 320 >4JG6-A nrPDB Length = 355 Score = 214 bits (546), Expect = 5e-56, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 111/272 (40%), Gaps = 25/272 (9%) Query: 186 SGWALNMKE-LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQ 242 ++ + ++ + IG G + ++ + AVK I D + + E ++ + Sbjct: 27 HRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKII--DKSKRDPTEEIEILLR 84 Query: 243 L-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 +H N++ L V ++ +Y+VTE M G L+D + + + + Sbjct: 85 YGQHPNIITLKDV-YDDGKYVYVVTELMKGGELLDKILRQKF--FSEREASAVLFTITKT 141 Query: 302 MEYLEGNNFVHRDLAARNVL-VSEDNV---AKVSDFGLTKEASSTQ---DTGKLPVKWTA 354 +EYL VHRDL N+L V E ++ DFG K+ + T + A Sbjct: 142 VEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVA 201 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPY---PRIPLKDVVPRVEKGYKMDAPDGC 411 PE L + + D+WS G+LL+ + + G P+ P ++++ R+ G K G Sbjct: 202 PEVLERQGYDAACDIWSLGVLLYTMLT-GYTPFANGPDDTPEEILARIGSG-KFSLSGGY 259 Query: 412 ----PPAVYDVMKNCWHLDAATRPTFLQLREQ 439 D++ H+D R T + Sbjct: 260 WNSVSDTAKDLVSKMLHVDPHQRLTAALVLRH 291 >3TAC-A nrPDB Length = 361 Score = 214 bits (546), Expect = 6e-56, Method: Composition-based stats. Identities = 67/290 (23%), Positives = 117/290 (40%), Gaps = 31/290 (10%) Query: 172 VMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDA- 228 V G++A D + + L + IGKG F V G + AVK + Sbjct: 12 VPRGSMADDDVLFEDVYE-------LCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKF 64 Query: 229 ------TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG 282 + + EAS+ L+H ++V+LL + G LY+V E+M L + R Sbjct: 65 TSSPGLSTEDLKREASICHMLKHPHIVELLETYSSD-GMLYMVFEFMDGADLCFEIVKRA 123 Query: 283 RSVL--GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV---AKVSDFGLTK 337 + + + EA+ Y NN +HRD+ VL++ K+ FG+ Sbjct: 124 DAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAI 183 Query: 338 EASSTQ---DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD 394 + + + APE ++ + + DVW G++L+ + S G +P+ + Sbjct: 184 QLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLS-GCLPFYGTKERL 242 Query: 395 VVPRVEKGYKMDAPD--GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 ++ YKM+ + D+++ LD A R T + E L H Sbjct: 243 FEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT---VYEALNH 289 >1G3N-A nrPDB Length = 326 Score = 214 bits (546), Expect = 6e-56, Method: Composition-based stats. Identities = 55/289 (19%), Positives = 113/289 (39%), Gaps = 44/289 (15%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR---GNKVAVKCIKNDATAQ----AFLAEASVMTQLR- 244 ++ + + IG+G +G V G VA+K ++ + + + E +V+ L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 245 --HSNLVQLLGVIV----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 H N+V+L V + + L +V E++ + L YL + + + + Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPE 356 +++L + VHRDL +N+LV+ K++DFGL + S + + + + APE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAV- 415 L + ++T D+WS G + E++ + + D + ++ + + P V Sbjct: 190 VLLQSSYATPVDLWSVGCIFAEMF-RRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 416 -------------------------YDVMKNCWHLDAATRPTFLQLREQ 439 D++ C + A R + Sbjct: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH 297 >4C0T-A nrPDB Length = 974 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 115/268 (42%), Gaps = 23/268 (8%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLA-----EASVMTQL 243 N+ + K + +G+G + V+L + G + AVK + + E + +L Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRL 323 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 + V L ++K LY V +Y + G L+ ++ L +C F + +A++ Sbjct: 324 SNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYN--TLNEECTRHFGAQILDAIK 381 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK------------LPVK 351 Y+ N +HRDL N+L+ + +++DFG + D + + Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC 411 + +PE L K DVW+FG +++++ + G+ P+ ++ K + G Sbjct: 442 YVSPELLENKYCGKPGDVWAFGCIIYQMIA-GKPPFKATNEYLTFQKITK-LQFAFSAGF 499 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQ 439 P + D++K L + R T ++++ Sbjct: 500 PTIIRDLIKKILVLQPSRRATIPEIQKH 527 >1CM8-A nrPDB Length = 367 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 120/313 (38%), Gaps = 51/313 (16%) Query: 173 MEGTVAAQDEFYRSGWALNMKE----LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCI-- 224 M A+ FYR E + LQ +G G +G V G KVA+K + Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 Query: 225 --KNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKG-----GLYIVTEYMAKGSLVDY 277 +++ A+ E ++ +RH N++ LL V ++ Y+V +M L Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKL 119 Query: 278 LRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 337 ++ LG D + + + + Y+ +HRDL N+ V+ED K+ DFGL + Sbjct: 120 MKHEK---LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR 176 Query: 338 EASSTQDTGKLPVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396 +A S + + APE + +++ D+WS G ++ E+ + G+ + D + Sbjct: 177 QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQL 235 Query: 397 PRVE-------------------KGYKMDAPD-----------GCPPAVYDVMKNCWHLD 426 + K Y P+ P ++++ LD Sbjct: 236 KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD 295 Query: 427 AATRPTFLQLREQ 439 A R T + Sbjct: 296 AEQRVTAGEALAH 308 >3UC3-A nrPDB Length = 361 Score = 213 bits (544), Expect = 8e-56, Method: Composition-based stats. Identities = 64/262 (24%), Positives = 102/262 (38%), Gaps = 17/262 (6%) Query: 191 NMKELKLLQTIGKGEFGD--VMLGDYRGNKVAVKCIKNDA-TAQAFLAEASVMTQLRHSN 247 + ++ IG G FG +M VAVK I+ A + E LRH N Sbjct: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRHPN 77 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +V+ VI+ L I+ EY + G L + + + GR D F + + Y Sbjct: 78 IVRFKEVILT-PTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYCHS 134 Query: 308 NNFVHRDLAARNVLVSED--NVAKVSDFGLTKE--ASSTQDTGKLPVKWTAPEALREKKF 363 HRDL N L+ K+ DFG +K S + + APE L +++ Sbjct: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 Query: 364 STK-SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG---YKMDAPDG--CPPAVYD 417 K +DVWS G+ L+ + G P+ + + K PD P Sbjct: 195 DGKIADVWSCGVTLYVML-VGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++ + D ATR + +++ Sbjct: 254 LISRIFVADPATRISIPEIKTH 275 >4TPT-A nrPDB Length = 303 Score = 213 bits (544), Expect = 9e-56, Method: Composition-based stats. Identities = 77/280 (27%), Positives = 128/280 (45%), Gaps = 35/280 (12%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK--NDATAQAFLAEASVMTQLRHSNLV 249 +L + +GKG FG + ++ G + +K + ++ T + FL E VM L H N++ Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVL 60 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 + +GV+ ++K L ++TEY+ G+L D+LRS ++F+ + M YL Sbjct: 61 KFIGVLYKDK-KLNLLTEYIEGGTLKDFLRSM--DPFPWQQKVRFAKGIASGMAYLHSMC 117 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTK-----------------------EASSTQDTG 346 +HRDL + N L+ D V+DFGL++ + T Sbjct: 118 IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTV 177 Query: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR---VEKGY 403 W APE L K + D++SFGI+L EI G+V L + V+ + Sbjct: 178 VGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII--GQVYADPDCLPRTLDFGLNVKLFW 235 Query: 404 KMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + P CPPA + + C L+ +RP F +L + E + Sbjct: 236 EKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 275 >3KN6-A nrPDB Length = 325 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 113/276 (40%), Gaps = 29/276 (10%) Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEAS 238 FY+ + L++K+ + +G+G F ++ AVK I A E + Sbjct: 4 SPFYQH-YDLDLKD----KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEA-NTQKEIT 57 Query: 239 VMTQLR-HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 + H N+V+L V ++ ++V E + G L + ++ + Sbjct: 58 ALKLCEGHPNIVKLHEVF-HDQLHTFLVMELLNGGELFERIKKKKH--FSETEASYIMRK 114 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLV---SEDNVAKVSDFGLTKEASSTQD---TGKLPVK 351 + A+ ++ VHRDL N+L +++ K+ DFG + T + Sbjct: 115 LVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLH 174 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK-------DVVPRVEKG-- 402 + APE L + + D+WS G++L+ + S G+VP+ +++ +++KG Sbjct: 175 YAAPELLNQNGYDESCDLWSLGVILYTMLS-GQVPFQSHDRSLTCTSAVEIMKKIKKGDF 233 Query: 403 -YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLR 437 ++ +A D+++ +D R LR Sbjct: 234 SFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLR 269 >2J90-A nrPDB Length = 304 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 53/269 (19%), Positives = 113/269 (42%), Gaps = 26/269 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDA--------TAQAFLAEASVMTQ 242 ++ + +G G+F V +G + A K IK + + E +++ + Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 +RH N++ L + E K + ++ E ++ G L D+L + L D +F + + + Sbjct: 86 IRHPNIITLHDIF-ENKTDVVLILELVSGGELFDFLAEKES--LTEDEATQFLKQILDGV 142 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNV----AKVSDFGLTKEASSTQDTGKL--PVKWTAPE 356 YL H DL N+++ + NV K+ DFG+ + + + + ++ APE Sbjct: 143 HYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPE 202 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---GYKMDAPDGCPP 413 + + ++D+WS G++ + + S G P+ ++ + + + + Sbjct: 203 IVNYEPLGLEADMWSIGVITYILLS-GASPFLGETKQETLTNISAVNYDFDEEYFSNTSE 261 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQLEH 442 D ++ D R T + + LEH Sbjct: 262 LAKDFIRRLLVKDPKRRMT---IAQSLEH 287 >5EFQ-A nrPDB Length = 347 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 118/295 (40%), Gaps = 52/295 (17%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRHS 246 + ++ IG+G +G V + G VA+K ++ D + F + E ++ QL H Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 247 NLVQLLGV---------IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 +++ + + ++KG Y+V EYM L+ L S G + + F Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFNENHIKSFMRQ 128 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD----TGKLPVKWT 353 + E ++Y NF+HRD+ N+L++ K++DFGL + SS + + + + Sbjct: 129 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 188 Query: 354 APEALR-EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 PE L E++++ DVWS G +L E+++ + + + + + P P Sbjct: 189 PPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANQELAQLELISRICGSPCPAVWP 247 Query: 413 PAVY-----------------------------DVMKNCWHLDAATRPTFLQLRE 438 + D+ LD + R T Q + Sbjct: 248 DVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQ 302 >4AU8-A nrPDB Length = 296 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 63/289 (21%), Positives = 123/289 (42%), Gaps = 41/289 (14%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDATAQ----AFLAEASVMTQ 242 A+ ++ + L+ IG+G +G V R VA+K ++ D + + L E ++ + Sbjct: 2 AMGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKE 61 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L+H N+V+L V+ +K L +V E+ + L Y S L + + F + + + Sbjct: 62 LKHKNIVRLHDVLHSDK-KLTLVFEFCDQ-DLKKYFDSCNGD-LDPEIVKSFLFQLLKGL 118 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTGKLPVKWTAPEALR 359 + N +HRDL +N+L++ + K++DFGL + + + + P+ L Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 178 Query: 360 EKK-FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD----------AP 408 K +ST D+WS G + E+ + GR +P + D + R+ + P Sbjct: 179 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 238 Query: 409 DGCPPAVY------------------DVMKNCWHLDAATRPTFLQLREQ 439 D P +Y D+++N + R + + + Sbjct: 239 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQH 287 >3A8W-A nrPDB Length = 345 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 64/260 (24%), Positives = 115/260 (44%), Gaps = 23/260 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKN-----DATAQAFLAEASVMTQ 242 L +++ LL+ IG+G + V+L + A+K +K D E V Q Sbjct: 6 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 65 Query: 243 L-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 H LV L + + L+ V EY+ G L+ +++ + + L + +S ++ A Sbjct: 66 ASNHPFLVGLH-SCFQTESRLFFVIEYVNGGDLMFHMQRQRK--LPEEHARFYSAEISLA 122 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEAL 358 + YL ++RDL NVL+ + K++D+G+ KE T T + APE L Sbjct: 123 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 182 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPY--------PRIPLKDVVPRVEKGYKMDAPDG 410 R + + D W+ G+L++E+ + GR P+ P +D + +V ++ P Sbjct: 183 RGEDYGFSVDWWALGVLMFEMMA-GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRS 241 Query: 411 CPPAVYDVMKNCWHLDAATR 430 V+K+ + D R Sbjct: 242 LSVKAASVLKSFLNKDPKER 261 >6CMJ-A nrPDB Length = 321 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 120/273 (43%), Gaps = 27/273 (9%) Query: 190 LNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDA-------------TAQAFL 234 + + + L IGKG +G V L + A+K + + Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 235 AEASVMTQLRHSNLVQLLGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 293 E +++ +L H N+V+L+ V+ + + LY+V E + +G +++ L D Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV---PTLKPLSEDQARF 147 Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTGKLPV 350 + D+ + +EYL +HRD+ N+LV ED K++DFG++ E + Sbjct: 148 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 207 Query: 351 KWTAPEALREKK--FSTKS-DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMD 406 + APE+L E + FS K+ DVW+ G+ L+ + FG+ P+ + + +++ + + Sbjct: 208 AFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPFMDERIMCLHSKIKSQALEFP 266 Query: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + D++ + +R +++ Sbjct: 267 DQPDIAEDLKDLITRMLDKNPESRIVVPEIKLH 299 >5TOS-A nrPDB Length = 395 Score = 211 bits (537), Expect = 6e-55, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 128/307 (41%), Gaps = 39/307 (12%) Query: 176 TVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY-----------RGNKVAVKCI 224 + F + L + + IG+G FG V G G +AVK + Sbjct: 48 SSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL 107 Query: 225 KNDATA--QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG 282 + + +L E + + QL H NLV+L+G +E++ L +V E+M KGSL ++L RG Sbjct: 108 NQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRG 166 Query: 283 --RSVLGGDCLLKFSLDVCEAMEYLEGN--NFVHRDLAARNVLVSEDNVAKVSDFGLTK- 337 L + +LD + + +L + ++RD+ A N+L+ D AK+SDFGL + Sbjct: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 Query: 338 ----EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV-----PYP 388 + S + APE + + +SDV+SFG+LL EI S R P Sbjct: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 Query: 389 RIPLKDVVPRVEKGYKMDAP--------DGCPPA---VYDVMKNCWHLDAATRPTFLQLR 437 L D + P + V C + +RPT Q+ Sbjct: 287 EENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 Query: 438 EQLEHIR 444 L+ ++ Sbjct: 347 RALQQLQ 353 >1V0B-A nrPDB Length = 288 Score = 210 bits (536), Expect = 7e-55, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 114/285 (40%), Gaps = 41/285 (14%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR-GNKVAVKCIKNDATAQAF----LAEASVMTQLRHS 246 M++ L+ IG+G +G V G A+K I+ + + + E S++ +L+HS Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V+L VI K L +V E++ + L L L F L + + Y Sbjct: 61 NIVKLYDVI-HTKKRLVLVFEHLDQ-DLKKLLDVCE-GGLESVTAKSFLLQLLNGIAYCH 117 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEALRE-KK 362 +HRDL +N+L++ + K++DFGL + + + + AP+ L KK Sbjct: 118 DRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP---------- 412 +ST D+WS G + E+ + G +P + D + R+ + P Sbjct: 178 YSTTIDIWSVGCIFAEMVN-GAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDP 236 Query: 413 ------------------PAVYDVMKNCWHLDAATRPTFLQLREQ 439 + D++ LD R T Q E Sbjct: 237 NFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEH 281 >2Y7J-A nrPDB Length = 365 Score = 210 bits (536), Expect = 8e-55, Method: Composition-based stats. Identities = 63/289 (21%), Positives = 121/289 (41%), Gaps = 29/289 (10%) Query: 176 TVAAQDEFYRSGWALNM-KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK------- 225 ++ +DE A ++ IG+G V +R G++ AVK ++ Sbjct: 76 SMGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLS 135 Query: 226 ---NDATAQAFLAEASVMTQLR-HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR 281 + +A E ++ Q+ H +++ L+ E +++V + M KG L DYL + Sbjct: 136 PEQLEEVREATRRETHILRQVAGHPHIITLIDS-YESSSFMFLVFDLMRKGELFDYLTEK 194 Query: 282 GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS 341 L + EA+ +L NN VHRDL N+L+ ++ ++SDFG + Sbjct: 195 --VALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP 252 Query: 342 TQDTG--KLPVKWTAPEALR------EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK 393 + + APE L+ + + D+W+ G++L+ + + G P+ Sbjct: 253 GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFWHRRQI 311 Query: 394 DVVPRVEKG-YKMDAP--DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 ++ + +G Y+ +P D V D++ +D R T Q + Sbjct: 312 LMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQH 360 >4KRC-A nrPDB Length = 317 Score = 210 bits (536), Expect = 9e-55, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 117/293 (39%), Gaps = 49/293 (16%) Query: 193 KELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIK---NDATAQAFLAEASVMTQLRHSN 247 + K L+ +G G + V G G VA+K +K + T + E S+M +L+H N Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG----RSVLGGDCLLKFSLDVCEAME 303 +V+L VI E L +V E+M L Y+ SR L + + F + + + Sbjct: 65 IVRLYDVIHTE-NKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALRE 360 + N +HRDL +N+L+++ K+ DFGL + +T + + + + AP+ L Sbjct: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 Query: 361 -KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY---------------- 403 + +ST D+WS G +L E+ + G+ +P ++ + + Sbjct: 183 SRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 Query: 404 -----KMDAPDGCPPAVY------------DVMKNCWHLDAATRPTFLQLREQ 439 + P + D + L+ R + Q Sbjct: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 >2X4F-A nrPDB Length = 373 Score = 210 bits (535), Expect = 9e-55, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 117/286 (40%), Gaps = 24/286 (8%) Query: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKND--ATAQA 232 V A+ S + ++ E+ +G G FG V + G K+A K IK + Sbjct: 78 VTAKQGAVNSFYTVSKTEI-----LGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE 132 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 E SVM QL H+NL+QL E K + +V EY+ G L D + ++ D +L Sbjct: 133 VKNEISVMNQLDHANLIQLYDAF-ESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTIL 191 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDN--VAKVSDFGLTKEASSTQDTGK--L 348 F +CE + ++ +H DL N+L + K+ DFGL + + Sbjct: 192 -FMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFG 250 Query: 349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV---EKGYKM 405 ++ APE + S +D+WS G++ + + G P+ + + + + Sbjct: 251 TPEFLAPEVVNYDFVSFPTDMWSVGVIAY-MLLSGLSPFLGDNDAETLNNILACRWDLED 309 Query: 406 DAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH--IRTHELH 449 + + + + + R + E L+H + H+LH Sbjct: 310 EEFQDISEEAKEFISKLLIKEKSWRISAS---EALKHPWLSDHKLH 352 >4NST-A nrPDB Length = 351 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 125/312 (40%), Gaps = 59/312 (18%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRHS 246 + ++ IG+G +G V + G VA+K ++ D + F + E ++ QL H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 247 NLVQLLGV---------IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 ++V + + ++KG Y+V EYM L+ L S G D + F Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFSEDHIKSFMKQ 130 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD----TGKLPVKWT 353 + E +EY NF+HRD+ N+L++ K++DFGL + +S + + + + Sbjct: 131 LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 190 Query: 354 APEALR-EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP---- 408 PE L E++++ DVWS G +L E+++ + + + + + P Sbjct: 191 PPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANLELAQLELISRLCGSPCPAVWP 249 Query: 409 -------------------------DGCPPAVYDVMKNCWHLDAATRPTFLQLRE----- 438 P A D++ + LD + R T Q + Sbjct: 250 DVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK 309 Query: 439 --QLEHIRTHEL 448 +L + +L Sbjct: 310 DVELSKMAPPDL 321 >3ZUT-A nrPDB Length = 362 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 104/263 (39%), Gaps = 19/263 (7%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKN-DATAQAFLAEASVMTQLRHSN 247 + +L++ IG G FG L + VAVK I+ + + E LRH N Sbjct: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPN 76 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +V+ VI+ L IV EY + G L + + + GR D F + + Y Sbjct: 77 IVRFKEVILT-PTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHA 133 Query: 308 NNFVHRDLAARNVLVSED--NVAKVSDFGLTKE--ASSTQDTGKLPVKWTAPEALREKKF 363 HRDL N L+ K+ FG +K S + + APE L +K++ Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 Query: 364 STKS-DVWSFGILLWEIYSFGRVPYPR----IPLKDVVPRVEKGYKMDAPD--GCPPAVY 416 K DVWS G+ L+ + G P+ + + R+ + PD P Sbjct: 194 DGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHRILN-VQYAIPDYVHISPECR 251 Query: 417 DVMKNCWHLDAATRPTFLQLREQ 439 ++ + D A R + ++R Sbjct: 252 HLISRIFVADPAKRISIPEIRNH 274 >3UDB-A nrPDB Length = 317 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 66/263 (25%), Positives = 106/263 (40%), Gaps = 19/263 (7%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKN-DATAQAFLAEASVMTQLRHSN 247 + +L++ IG G FG L + VAVK I+ + + E LRH N Sbjct: 17 DSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRSLRHPN 76 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +V+ VI+ L IV EY + G L + + + GR D F + + Y Sbjct: 77 IVRFKEVILT-PTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYAHA 133 Query: 308 NNFVHRDLAARNVLVSED--NVAKVSDFGLTKE--ASSTQDTGKLPVKWTAPEALREKKF 363 HRDL N L+ K++DFG +K S + + APE L +K++ Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEY 193 Query: 364 STKS-DVWSFGILLWEIYSFGRVPYPR----IPLKDVVPRVEKGYKMDAPD--GCPPAVY 416 K DVWS G+ L+ + G P+ + + R+ + PD P Sbjct: 194 DGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHRILN-VQYAIPDYVHISPECR 251 Query: 417 DVMKNCWHLDAATRPTFLQLREQ 439 ++ + D A R + ++R Sbjct: 252 HLISRIFVADPAKRISIPEIRNH 274 >3NYO-A nrPDB Length = 576 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 56/273 (20%), Positives = 110/273 (40%), Gaps = 19/273 (6%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQA-----FLAE 236 + + + + +GKG FG+V G A K ++ + L E Sbjct: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 Query: 237 ASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296 ++ ++ +V L E K L +V M G L ++ G++ + ++ Sbjct: 235 KQILEKVNSRFVVSL-AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT--GKLPVKWTA 354 ++C +E L V+RDL N+L+ + ++SD GL Q V + A Sbjct: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMA 353 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK---DVVPRVEKGYKMDAPDGC 411 PE ++ ++++ D W+ G LL+E+ + G+ P+ + K + V R+ K + + Sbjct: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERF 412 Query: 412 PPAVYDVMKNCWHLDAATRP-----TFLQLREQ 439 P + D A R + +++E Sbjct: 413 SPQARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 >2W96-B nrPDB Length = 306 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 54/288 (18%), Positives = 110/288 (38%), Gaps = 43/288 (14%) Query: 193 KELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIK----NDATAQAFLAEASVMTQLR-- 244 + + IG G +G V + G+ VA+K ++ + + + E +++ +L Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 245 -HSNLVQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 H N+V+L+ V + + +V E++ + L YL L + + Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEA 357 +++L N VHRDL N+LV+ K++DFGL + S D + + + APE Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY- 416 L + ++T D+WS G + E++ + + D + ++ + D P V Sbjct: 183 LLQSTYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 241 Query: 417 -------------------------DVMKNCWHLDAATRPTFLQLREQ 439 ++ + R + + + Sbjct: 242 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 289 >3REP-A nrPDB Length = 271 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 74/267 (27%), Positives = 130/267 (48%), Gaps = 16/267 (5%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK----NDATAQAFLAEASVMTQLRH 245 ++ K+L L + + G++ G ++GN + VK +K + ++ F E + H Sbjct: 7 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 66 Query: 246 SNLVQLLGVIVEEK-GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 N++ +LG ++T +M GSL + L V+ +KF+LD+ M + Sbjct: 67 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAF 126 Query: 305 LEG-NNFVHRD-LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-PVKWTAPEALREK 361 L + R L +R+V++ ED A++S + S Q G++ W APEAL++K Sbjct: 127 LHTLEPLIPRHALNSRSVMIDEDMTARIS---MADVKFSFQSPGRMYAPAWVAPEALQKK 183 Query: 362 KFST---KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYD 417 T +D+WSF +LLWE+ + VP+ + ++ +V +G + P G P V Sbjct: 184 PEDTNRRSADMWSFAVLLWELVTR-EVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSK 242 Query: 418 VMKNCWHLDAATRPTFLQLREQLEHIR 444 +MK C + D A RP F + LE ++ Sbjct: 243 LMKICMNEDPAKRPKFDMIVPILEKMQ 269 >4EWQ-A nrPDB Length = 383 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 114/302 (37%), Gaps = 48/302 (15%) Query: 180 QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATA----QAF 233 + E ++ W + + + L +G G +G V G +VAVK + + + Sbjct: 33 RQELNKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRT 91 Query: 234 LAEASVMTQLRHSNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 E ++ ++H N++ LL V EE +Y+VT M L + ++ + L Sbjct: 92 YRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQK---LTD 147 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL 348 D + + ++Y+ + +HRDL N+ V+ED K+ DFGL + Sbjct: 148 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 207 Query: 349 PVKWTAPEA-LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD- 406 + APE L ++ D+WS G ++ E+ + GR +P D + + + Sbjct: 208 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPG 266 Query: 407 ---------------------APD--------GCPPAVYDVMKNCWHLDAATRPTFLQLR 437 P G P D+++ LD+ R T Q Sbjct: 267 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 326 Query: 438 EQ 439 Sbjct: 327 AH 328 >1PHK-A nrPDB Length = 298 Score = 208 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 108/272 (39%), Gaps = 29/272 (10%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCI-----------KNDATAQAFLAEASV 239 + + + +G+G V ++ + AVK I + +A L E + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 240 MTQLR-HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 + ++ H N++QL E ++V + M KG L DYL + L K + Sbjct: 77 LRKVSGHPNIIQLKDT-YETNTFFFLVFDLMKKGELFDYLTEK--VTLSEKETRKIMRAL 133 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPE 356 E + L N VHRDL N+L+ +D K++DFG + + + + APE Sbjct: 134 LEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPE 193 Query: 357 AL------REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-YKMDAP- 408 + + + D+WS G++++ + + G P+ ++ + G Y+ +P Sbjct: 194 IIECSMNDNHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHRKQMLMLRMIMSGNYQFGSPE 252 Query: 409 -DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 D V D++ + R T + Sbjct: 253 WDDYSDTVKDLVSRFLVVQPQKRYTAEEALAH 284 >4U41-A nrPDB Length = 332 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 115/263 (43%), Gaps = 19/263 (7%) Query: 195 LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK-NDATAQAFLAEASVMTQL-RHSNLVQ 250 +L++ +G G +G V G + G A+K + + + E +++ + H N+ Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 251 LLGVIVE-----EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 G ++ L++V E+ GS+ D +++ + L D + S ++ + +L Sbjct: 86 YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHL 145 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---QDTGKLPVKWTAPEALR--- 359 ++ +HRD+ +NVL++E+ K+ DFG++ + T ++T W APE + Sbjct: 146 HIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDE 205 Query: 360 --EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA-PDGCPPAVY 416 + + +SD+WS GI E+ + G P + + + + + Sbjct: 206 NPDATYDYRSDLWSCGITAIEM-AEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFF 264 Query: 417 DVMKNCWHLDAATRPTFLQLREQ 439 ++ C + RP+ QL + Sbjct: 265 SFIEGCLVKNYMQRPSTEQLLKH 287 >2YCR-A nrPDB Length = 323 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 67/272 (24%), Positives = 106/272 (38%), Gaps = 29/272 (10%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDATAQ----------AFLAEASV 239 E + +T+G G G+V L R KVA+K I A E + Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 + +L H ++++ + YIV E M G L D + R L + + Sbjct: 69 LKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKR--LKEATCKLYFYQML 124 Query: 300 EAMEYLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASST--QDTGKLPVKWTA 354 A++YL N +HRDL NVL+S ED + K++DFG +K T T + A Sbjct: 125 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 184 Query: 355 PEAL---REKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPD- 409 PE L ++ D WS G++L+ S G P+ + ++ G P+ Sbjct: 185 PEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQITSGKYNFIPEV 243 Query: 410 --GCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 D++K +D R T + Sbjct: 244 WAEVSEKALDLVKKLLVVDPKARFTTEEALRH 275 >1U5R-A nrPDB Length = 348 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 118/310 (38%), Gaps = 31/310 (10%) Query: 141 DEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQT 200 E +YF+ M A G L P V E F++ +L+ Sbjct: 17 TENLYFQGAMD-----PMPAGGRAGSLKDPDVAEL-------FFKDDPEKLFSDLR---E 61 Query: 201 IGKGEFGDVMLGDY--RGNKVAVKCI-----KNDATAQAFLAEASVMTQLRHSNLVQLLG 253 IG G FG V VA+K + +++ Q + E + +LRH N +Q G Sbjct: 62 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRG 121 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 + E ++V EY GS D L + L + + + + YL +N +HR Sbjct: 122 CYLREHTA-WLVMEYC-LGSASDLLEVHKK-PLQEVEIAAVTHGALQGLAYLHSHNMIHR 178 Query: 314 DLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALR---EKKFSTKSDVW 370 D+ A N+L+SE + K+ DFG + W APE + E ++ K DVW Sbjct: 179 DVKAGNILLSEPGLVKLGDFGSASIMAPANSF-VGTPYWMAPEVILAMDEGQYDGKVDVW 237 Query: 371 SFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA-VYDVMKNCWHLDAAT 429 S GI E+ + + P + + + + G + + +C Sbjct: 238 SLGITCIEL-AERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQD 296 Query: 430 RPTFLQLREQ 439 RPT L + Sbjct: 297 RPTSEVLLKH 306 >6E9W-A nrPDB Length = 443 Score = 207 bits (528), Expect = 7e-54, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 114/273 (41%), Gaps = 24/273 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQA-----FLAEASVMTQ 242 + ++ ++++ IG+G FG+V L ++ + A+K + + F E +M Sbjct: 99 MKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAF 158 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 +VQL ++ LY+V EYM G LV+ + + + ++ +V A+ Sbjct: 159 ANSPWVVQLF-YAFQDDRYLYMVMEYMPGGDLVNLMSNYD---VPEKWARFYTAEVVLAL 214 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTAPEAL 358 + + F+HRD+ N+L+ + K++DFG + KE DT + +PE L Sbjct: 215 DAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVL 274 Query: 359 REKK----FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-GYKMDAPD--GC 411 + + + + D WS G+ L+E+ G P+ L ++ + PD Sbjct: 275 KSQGGDGYYGRECDWWSVGVFLYEML-VGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDI 333 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 +++ D R + E H+ Sbjct: 334 SKEAKNLICAFLT-DREVRLGRNGVEEIKRHLF 365 >3ALO-A nrPDB Length = 327 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 74/279 (26%), Positives = 126/279 (45%), Gaps = 30/279 (10%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASV 239 W ++LK L IG+G +G V ++ G +AVK I+ ++ + L + V Sbjct: 14 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 73 Query: 240 -MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAK--GSLVDYLRSRGRSVLGGDCLLKFSL 296 M +VQ G + E G +I E M+ Y+ S V+ + L K +L Sbjct: 74 VMRSSDCPYIVQFYGALFRE-GDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITL 132 Query: 297 DVCEAMEYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS----TQDTGKLPVK 351 +A+ +L+ N +HRD+ N+L+ K+ DFG++ + T+D G P Sbjct: 133 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP-- 190 Query: 352 WTAPEAL----REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA 407 + APE + + + +SDVWS GI L+E+ + GR PYP+ V ++ + K D Sbjct: 191 YMAPERIDPSASRQGYDVRSDVWSLGITLYELAT-GRFPYPKWN--SVFDQLTQVVKGDP 247 Query: 408 PD-------GCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 P P+ + + C D + RP + +L + Sbjct: 248 PQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKH 286 >4TNB-A nrPDB Length = 590 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 53/264 (20%), Positives = 97/264 (36%), Gaps = 14/264 (5%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQA-----FLAE 236 + + + + +GKG FG+V G A K ++ + L E Sbjct: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNE 234 Query: 237 ASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296 ++ ++ +V L E K L +V M G L ++ + G + L ++ Sbjct: 235 KQILEKVNSQFVVNL-AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTA 354 ++ +E L N V+RDL N+L+ + ++SD GL + V + A Sbjct: 294 EILCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMA 353 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA---PDGC 411 PE L +++ D W G L++E+ G+ P+ K V++ Sbjct: 354 PEVLNNQRYGLSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDRRVLETEEVYSHKF 412 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQ 435 + K DA R + Sbjct: 413 SEEAKSICKMLLTKDAKQRLGCQE 436 >5YV8-A nrPDB Length = 298 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 122/292 (41%), Gaps = 42/292 (14%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDA--------------- 228 SG + + + L IGKG +G V L + A+K + Sbjct: 6 SGDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRG 65 Query: 229 -------------TAQAFLAEASVMTQLRHSNLVQLLGVIVEE-KGGLYIVTEYMAKGSL 274 + E +++ +L H N+V+L+ V+ + + LY+V E + +G + Sbjct: 66 TRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV 125 Query: 275 VDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG 334 ++ L D + D+ + +EYL +HRD+ N+LV ED K++DFG Sbjct: 126 MEV---PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFG 182 Query: 335 LTKEASSTQ---DTGKLPVKWTAPEALREKK--FSTKS-DVWSFGILLWEIYSFGRVPYP 388 ++ E + + APE+L E + FS K+ DVW+ G+ L+ + FG+ P+ Sbjct: 183 VSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPFM 241 Query: 389 RIPLKDVVPRVE-KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + + +++ + + + D++ + +R +++ Sbjct: 242 DERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLH 293 >4EQM-A nrPDB Length = 294 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 65/267 (24%), Positives = 122/267 (45%), Gaps = 20/267 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI-----KNDATAQAFLAEASVMTQLRH 245 + K++ +G G V L + KVA+K I + + T + F E +QL H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+V ++ V EE Y+V EY+ +L +Y+ S G L D + F+ + + +++ Sbjct: 71 QNIVSMIDV-DEEDDCYYLVMEYIEGPTLSEYIESHG--PLSVDTAINFTNQILDGIKHA 127 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK----LPVKWTAPEALREK 361 VHRD+ +N+L+ + K+ DFG+ K S T T V++ +PE + + Sbjct: 128 HDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGE 187 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV-VPRVEK---GYKMDAPDGCPPAVYD 417 +D++S GI+L+E+ G P+ + + ++ D P ++ + Sbjct: 188 ATDECTDIYSIGIVLYEML-VGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSLSN 246 Query: 418 VMKNCWHLDAATR-PTFLQLREQLEHI 443 V+ D A R T ++++ L + Sbjct: 247 VILRATEKDKANRYKTIQEMKDDLSSV 273 >3Q4U-A nrPDB Length = 301 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 129/296 (43%), Gaps = 48/296 (16%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLA-EASVMTQLRHSNLVQL 251 +++ LL+ +GKG +G+V G ++G VAVK + F E LRH N++ Sbjct: 8 RDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 67 Query: 252 LGVIVEEK---GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE-- 306 + + + L+++T Y GSL DYL+ + L L+ L + + +L Sbjct: 68 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQ---LTTLDTVSCLRIVLSIASGLAHLHIE 124 Query: 307 ------GNNFVHRDLAARNVLVSEDNVAKVSDFGLT-------KEASSTQDTGKLPVKWT 353 HRDL ++N+LV ++ ++D GL + + ++ Sbjct: 125 IFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYM 184 Query: 354 APEALREK------KFSTKSDVWSFGILLWE----IYSFG-----RVPY----PRIPLKD 394 APE L E + D+W+FG++LWE + S G + P+ P P + Sbjct: 185 APEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFE 244 Query: 395 VVPRV--EKGYKMDAP-----DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + +V + + P D ++ +MK CW+ + + R T L++++ L I Sbjct: 245 DMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 300 >2Y4I-B nrPDB Length = 319 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 74/289 (25%), Positives = 134/289 (46%), Gaps = 27/289 (9%) Query: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK----NDATAQA 232 A+Q + W + ++L++ + IGKG FG V G + G VA++ I N+ +A Sbjct: 17 KASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGE-VAIRLIDIERDNEDQLKA 75 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 F E Q RH N+V +G + L I+T +L +R + VL + Sbjct: 76 FKREVMAYRQTRHENVVLFMGACMSPP-HLAIITSLCKGRTLYSVVRD-AKIVLDVNKTR 133 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGK 347 + + ++ + M YL +H+DL ++NV + ++DFGL +A +D + Sbjct: 134 QIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLR 192 Query: 348 LPVKW---TAPEALRE---------KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 + W APE +R+ FS SDV++ G + +E+++ P+ P + + Sbjct: 193 IQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA-REWPFKTQPAEAI 251 Query: 396 VPRVEKGYKMDAPD-GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 + ++ G K + G + D++ CW + RPTF +L + LE + Sbjct: 252 IWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 300 >2GCD-A nrPDB Length = 309 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 63/268 (23%), Positives = 106/268 (39%), Gaps = 19/268 (7%) Query: 183 FYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCI-----KNDATAQAFLA 235 F++ +L+ IG G FG V VA+K + +++ Q + Sbjct: 8 FFKDDPEKLFSDLR---EIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIK 64 Query: 236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 E + +LRH N +Q G + E ++V EY GS D L + L + + Sbjct: 65 EVRFLQKLRHPNTIQYRGCYLREHTA-WLVMEYC-LGSASDLLEVHKK-PLQEVEIAAVT 121 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAP 355 + + YL +N +HRD+ A N+L+SE + K+ DFG + W AP Sbjct: 122 HGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSF-VGTPYWMAP 180 Query: 356 EALR---EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 E + E ++ K DVWS GI E+ + + P + + + + G Sbjct: 181 EVILAMDEGQYDGKVDVWSLGITCIEL-AERKPPLFNMNAMSALYHIAQNESPALQSGHW 239 Query: 413 PA-VYDVMKNCWHLDAATRPTFLQLREQ 439 + + +C RPT L + Sbjct: 240 SEYFRNFVDSCLQKIPQDRPTSEVLLKH 267 >6ED6-A nrPDB Length = 415 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 112/279 (40%), Gaps = 28/279 (10%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQA-----FLAEASV 239 G + ++ +++ IG+G FG+V L ++ ++ A+K + + F E + Sbjct: 82 GLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI 141 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 M +VQL ++ LY+V EYM G LV+ + + + ++ +V Sbjct: 142 MAFANSPWVVQLF-YAFQDDRYLYMVMEYMPGGDLVNLMSNYD---VPEKWAKFYTAEVV 197 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAP 355 A++ + +HRD+ N+L+ + K++DFG + T DT + +P Sbjct: 198 LALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISP 257 Query: 356 EALREKK----FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK---MDAP 408 E L+ + + + D WS G+ L+E+ G P+ L ++ Sbjct: 258 EVLKSQGGDGFYGRECDWWSVGVFLYEML-VGDTPFYADSLVGTYSKIMDHKNSLCFPED 316 Query: 409 DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 +++ D R R +E IR H Sbjct: 317 AEISKHAKNLICAFLT-DREVRLG----RNGVEEIRQHP 350 >2YAB-A nrPDB Length = 361 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 50/266 (18%), Positives = 104/266 (39%), Gaps = 23/266 (8%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA--------QAFLAEASVMTQ 242 + + +G G+F V + G + A K IK + + E S++ Q Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQ 71 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + H N++ L V E + + ++ E ++ G L D+L + L + F + + + Sbjct: 72 VLHPNIITLHDV-YENRTDVVLILELVSGGELFDFLAQKES--LSEEEATSFIKQILDGV 128 Query: 303 EYLEGNNFVHRDLAARNVLVSEDN----VAKVSDFGLTKEASSTQDTGKL--PVKWTAPE 356 YL H DL N+++ + N K+ DFGL E + + ++ APE Sbjct: 129 NYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPE 188 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---GYKMDAPDGCPP 413 + + ++D+WS G++ + + S G P+ ++ + + + + Sbjct: 189 IVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITAVSYDFDEEFFSQTSE 247 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQ 439 D ++ + R T + Sbjct: 248 LAKDFIRKLLVKETRKRLTIQEALRH 273 >3HNG-A nrPDB Length = 360 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 71/167 (42%), Positives = 106/167 (63%), Gaps = 6/167 (3%) Query: 283 RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST 342 + + + L+ +S V ME+L +HRDLAARN+L+SE+NV K+ DFGL ++ Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 343 QD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL-KDVV 396 D +LP+KW APE++ +K +STKSDVWS+G+LLWEI+S G PYP + + +D Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFC 312 Query: 397 PRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 R+ +G +M AP+ P +Y +M +CWH D RP F +L E+L + Sbjct: 313 SRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDL 359 Score = 92.6 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 42/125 (33%), Positives = 63/125 (50%), Gaps = 12/125 (9%) Query: 182 EFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDATA---Q 231 + S W + LKL +++G+G FG V+ G K VAVK +K ATA + Sbjct: 16 PYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYK 75 Query: 232 AFLAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS-RGRSVLGGD 289 A + E ++T + H N+V LLG ++ G L ++ EY G+L +YL+S R L D Sbjct: 76 ALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKD 135 Query: 290 CLLKF 294 L Sbjct: 136 AALHM 140 >3GUB-A nrPDB Length = 295 Score = 205 bits (522), Expect = 4e-53, Method: Composition-based stats. Identities = 56/269 (20%), Positives = 111/269 (41%), Gaps = 26/269 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDA--------TAQAFLAEASVMTQ 242 + +G G+F V + G + A K IK + + E S++ + Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 ++H N++ L V E K + ++ E +A G L D+L + L + +F + + Sbjct: 71 IQHPNVITLHEV-YENKTDVILIGELVAGGELFDFLAEKES--LTEEEATEFLKQILNGV 127 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNV----AKVSDFGLTKEASSTQDTGKL--PVKWTAPE 356 YL H DL N+++ + NV K+ DFGL + + + ++ APE Sbjct: 128 YYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPE 187 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-GYKMDA--PDGCPP 413 + + ++D+WS G++ + + S G P+ ++ + V Y+ + Sbjct: 188 IVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANVSAVNYEFEDEYFSNTSA 246 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQLEH 442 D ++ D R T +++ L+H Sbjct: 247 LAKDFIRRLLVKDPKKRMT---IQDSLQH 272 >3ZDU-A nrPDB Length = 325 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 116/288 (40%), Gaps = 43/288 (14%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI---KNDATAQAFLAEASVMTQLRH 245 +M+ + L +G+G +G VM ++ G VA+K + + + E + Q H Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHH 60 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 NLV L+ V +K +++V E++ L + L L K+ + A++YL Sbjct: 61 ENLVNLIEVF-RQKKKIHLVFEFIDHTVLDELQHYC--HGLESKRLRKYLFQILRAIDYL 117 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ---DTGKLPVKWTAPE-ALREK 361 NN +HRD+ N+LVS+ + K+ DFG + ++ D + APE L++ Sbjct: 118 HSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDT 177 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE--------------------K 401 + D+W+ G ++ E+ + G P D++ ++ Sbjct: 178 SYGKPVDIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFA 236 Query: 402 GYKMDA---PDGCPPA-------VYDVMKNCWHLDAATRPTFLQLREQ 439 G + P + D++ C +D A R + L Sbjct: 237 GVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHH 284 >3GC9-A nrPDB Length = 370 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 119/302 (39%), Gaps = 48/302 (15%) Query: 180 QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDATA----QAF 233 + E ++ W + + L+ L+ +G G +G V KVAVK + + + Sbjct: 16 RQELNKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRT 74 Query: 234 LAEASVMTQLRHSNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 E ++ L+H N++ LL V E+ +Y+VT M L + ++S+ L Sbjct: 75 YRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKSQ---ALSD 130 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL 348 + + + ++Y+ +HRDL NV V+ED+ ++ DFGL ++A Sbjct: 131 EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYVA 190 Query: 349 PVKWTAPEA-LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA 407 + APE L ++ D+WS G ++ E+ G+ +P D + R+ + + Sbjct: 191 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGTPS 249 Query: 408 PD------------------------------GCPPAVYDVMKNCWHLDAATRPTFLQLR 437 P+ G P D++ LD+ R + + Sbjct: 250 PEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEAL 309 Query: 438 EQ 439 Sbjct: 310 AH 311 >3I6U-A nrPDB Length = 419 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 106/272 (38%), Gaps = 29/272 (10%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDATAQ----------AFLAEASV 239 E + +T+G G G+V L R KVA++ I A E + Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 + +L H ++++ + YIV E M G L D + R L + + Sbjct: 194 LKKLNHPCIIKIKNFF--DAEDYYIVLELMEGGELFDKVVGNKR--LKEATCKLYFYQML 249 Query: 300 EAMEYLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASST--QDTGKLPVKWTA 354 A++YL N +HRDL NVL+S ED + K++DFG +K T T + A Sbjct: 250 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 309 Query: 355 PEAL---REKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPD- 409 PE L ++ D WS G++L+ S G P+ + ++ G P+ Sbjct: 310 PEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQITSGKYNFIPEV 368 Query: 410 --GCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 D++K +D R T + Sbjct: 369 WAEVSEKALDLVKKLLVVDPKARFTTEEALRH 400 >4OTD-A nrPDB Length = 341 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 62/254 (24%), Positives = 112/254 (44%), Gaps = 19/254 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKN-----DATAQAFLAEASVMTQ 242 L +++ K L +G+G FG V+L ++R G A+K +K ++ + E ++ Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 243 LR---HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 + H LV L G + + V EY A G L+ ++ S V + +S V Sbjct: 69 VTSAGHPFLVNLFG-CFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYSACVV 124 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQDTGKLPVKWTAPE 356 +++L + V+RDL N+L+ + K++DFGL KE T ++ APE Sbjct: 125 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 184 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY 416 L + ++ D W G+LL+E+ G P+P ++V + ++ P Sbjct: 185 VLTDTSYTRAVDWWGLGVLLYEML-VGESPFPGDDEEEVFDSIVND-EVRYPRFLSAEAI 242 Query: 417 DVMKNCWHLDAATR 430 +M+ + R Sbjct: 243 GIMRRLLRRNPERR 256 >3UTO-A nrPDB Length = 573 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 115/277 (41%), Gaps = 21/277 (7%) Query: 181 DEFYRSGWALN----MKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCI--KNDATAQA 232 ++Y + + + + +G G FG V GN A K + +++ + Sbjct: 141 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 200 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 E M+ LRH LV L E+ + ++ E+M+ G L + + + + + D + Sbjct: 201 VRKEIQTMSVLRHPTLVNLHDAF-EDDNEMVMIYEFMSGGELFEKV-ADEHNKMSEDEAV 258 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVS--EDNVAKVSDFGLTKEASSTQD--TGKL 348 ++ VC+ + ++ NN+VH DL N++ + N K+ DFGLT Q Sbjct: 259 EYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTG 318 Query: 349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---GYKM 405 ++ APE K +D+WS G+L + + S G P+ + + V+ Sbjct: 319 TAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLS-GLSPFGGENDDETLRNVKSCDWNMDD 377 Query: 406 DAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 A G D ++ D TR T + + LEH Sbjct: 378 SAFSGISEDGKDFIRKLLLADPNTRMT---IHQALEH 411 >3VHK-A nrPDB Length = 368 Score = 204 bits (519), Expect = 7e-53, Method: Composition-based stats. Identities = 72/189 (38%), Positives = 111/189 (58%), Gaps = 11/189 (5%) Query: 268 YMAKGSLVDYLRSRG-----RSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV 322 ++ + SL D + L + L+ +S V + ME+L +HRDLAARN+L+ Sbjct: 174 FVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILL 233 Query: 323 SEDNVAKVSDFGLTKEASSTQD-----TGKLPVKWTAPEALREKKFSTKSDVWSFGILLW 377 SE NV K+ DFGL ++ D +LP+KW APE + ++ ++ +SDVWSFG+LLW Sbjct: 234 SEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLW 293 Query: 378 EIYSFGRVPYPRIPLKDVV-PRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 EI+S G PYP + + + R+++G +M APD P +Y M +CWH + + RPTF +L Sbjct: 294 EIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSEL 353 Query: 437 REQLEHIRT 445 E L ++ Sbjct: 354 VEHLGNLLQ 362 Score = 92.6 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 35/117 (29%), Positives = 55/117 (47%), Gaps = 11/117 (9%) Query: 182 EFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDA---TAQ 231 + S W LKL + +G+G FG V+ D G VAVK +K A + Sbjct: 18 PYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR 77 Query: 232 AFLAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 A ++E ++ + H N+V LLG + G L ++ E+ G+L YLRS+ + Sbjct: 78 ALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVP 134 >3FXW-A nrPDB Length = 336 Score = 204 bits (519), Expect = 7e-53, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 109/265 (41%), Gaps = 22/265 (8%) Query: 193 KELKL-LQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRH-SNL 248 + +L Q +G G G V+ +R G K A+K + + A+ E Q ++ Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQ---EVDHHWQASGGPHI 84 Query: 249 VQLLGVI---VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 V +L V K L I+ E M G L ++ RG + D+ A+++L Sbjct: 85 VCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFL 144 Query: 306 EGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEASST-QDTGKLPVKWTAPEALREK 361 +N HRD+ N+L + D V K++DFG KE + T + APE L + Sbjct: 145 HSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPE 204 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM-----DAPD--GCPPA 414 K+ D+WS G++++ + G P+ + + P +++ ++ P+ Sbjct: 205 KYDKSCDMWSLGVIMYILLC-GFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSED 263 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQ 439 +++ D R T Q Sbjct: 264 AKQLIRLLLKTDPTERLTITQFMNH 288 >4AW2-A nrPDB Length = 437 Score = 203 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 111/282 (39%), Gaps = 34/282 (12%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKN-----DATAQAFLAEAS 238 L+ ++ ++L+ IG+G FG+V + + A+K + A F E Sbjct: 67 KQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERD 126 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 V+ + L ++ LY+V +Y G L+ L S+ L + + ++ Sbjct: 127 VLVNGDSKWITTLH-YAFQDDNNLYLVMDYYVGGDLLTLL-SKFEDRLPEEMARFYLAEM 184 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTA 354 A++ + ++VHRD+ N+L+ + +++DFG L ++ + + + Sbjct: 185 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYIS 244 Query: 355 PEALR-----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-GYKMDAP 408 PE L+ + ++ + D WS G+ ++E+ +G P+ L + ++ + P Sbjct: 245 PEILQAMEGGKGRYGPECDWWSLGVCMYEML-YGETPFYAESLVETYGKIMNHKERFQFP 303 Query: 409 ---DGCPPAVYDVMKNCW-----------HLDAATRPTFLQL 436 D+++ D P F + Sbjct: 304 TQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGI 345 >3TKU-A nrPDB Length = 433 Score = 203 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 49/258 (18%), Positives = 106/258 (41%), Gaps = 23/258 (8%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKN-----DATAQAFLAEAS 238 L+ ++ ++++ IG+G FG+V + + + A+K + A F E Sbjct: 83 KEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERD 142 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 V+ + L +++ LY+V +Y G L+ L S+ L D + ++ Sbjct: 143 VLVNGDCQWITALH-YAFQDENHLYLVMDYYVGGDLLTLL-SKFEDKLPEDMARFYIGEM 200 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST----QDTGKLPVKWTA 354 A++ + ++VHRD+ NVL+ + +++DFG + + + + Sbjct: 201 VLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYIS 260 Query: 355 PEALRE-----KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-GYKMDAP 408 PE L+ K+ + D WS G+ ++E+ +G P+ L + ++ + P Sbjct: 261 PEILQAMEDGMGKYGPECDWWSLGVCMYEML-YGETPFYAESLVETYGKIMNHEERFQFP 319 Query: 409 D---GCPPAVYDVMKNCW 423 D+++ Sbjct: 320 SHVTDVSEEAKDLIQRLI 337 >5WNL-A nrPDB Length = 342 Score = 203 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 72/277 (25%), Positives = 119/277 (42%), Gaps = 28/277 (10%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK----NDATAQAFLAEASVMTQ 242 + E + +G G FG V + K +A+KC +D L EA M Sbjct: 16 TFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEM 75 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + ++ + G+ E + +V EYM GSL L S L D + + M Sbjct: 76 AKFRYILPVYGICQEP---VGLVMEYMETGSLEKLLAS---EPLPWDLRFRIVHETAVGM 129 Query: 303 EYLE--GNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKWTA 354 +L +H +L N+L+ K+SDFGL K + D + + Sbjct: 130 NFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLP 189 Query: 355 PEALREKK--FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 PE +REK F TK DV+SF I++W + + + + ++ +V KG++ + P C Sbjct: 190 PERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICR 249 Query: 413 P------AVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 P ++ +M+ CWH D RPTF ++ + E + Sbjct: 250 PRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDL 286 >4MYG-A nrPDB Length = 372 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 113/312 (36%), Gaps = 51/312 (16%) Query: 180 QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI----KNDATAQAF 233 + + ++ W L + G G +G V + G KVA+K + +++ A+ Sbjct: 31 KQDVNKTAWELPKTYVSPTHV-GSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRA 89 Query: 234 LAEASVMTQLRHSNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 E ++ ++H N++ LL V Y+V +M L + Sbjct: 90 YRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIM----GMEFSE 144 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL 348 + + + + ++Y+ VHRDL N+ V+ED K+ DFGL + A + + Sbjct: 145 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 204 Query: 349 PVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-------- 399 + APE + ++ D+WS G ++ E+ + G+ + D + ++ Sbjct: 205 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPG 263 Query: 400 -----------EKGYKMDAP-----------DGCPPAVYDVMKNCWHLDAATRPTFLQLR 437 K Y P P D+++ LD R T Q Sbjct: 264 TEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQAL 323 Query: 438 EQ--LEHIRTHE 447 E R E Sbjct: 324 THPFFEPFRDPE 335 >1UA2-A nrPDB Length = 346 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 65/288 (22%), Positives = 114/288 (39%), Gaps = 46/288 (15%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIK-------NDATAQAFLAEASVMTQL 243 K + L +G+G+F V + VA+K IK D + L E ++ +L Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H N++ LL K + +V ++M ++ + VL + + L + +E Sbjct: 70 SHPNIIGLLDAFGH-KSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEALRE 360 YL + +HRDL N+L+ E+ V K++DFGL K S + + APE L Sbjct: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 Query: 361 -KKFSTKSDVWSFGILLWEIYSFGRVPY-PRIPLKDVVPRVEKGYKMDA----PDGCP-- 412 + + D+W+ G +L E+ RVP+ P D + R+ + PD C Sbjct: 187 ARMYGVGVDMWAVGCILAELLL--RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 Query: 413 ---------------------PAVYDVMKNCWHLDAATRPTFLQLREQ 439 + D+++ + + R T Q + Sbjct: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 >4QTB-A nrPDB Length = 380 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 110/292 (37%), Gaps = 51/292 (17%) Query: 194 ELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCI---KNDATAQAFLAEASVMTQLRHSNL 248 LQ IG+G +G V R +VA+K I ++ Q L E ++ + RH N+ Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 101 Query: 249 VQLLGVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 + + ++ +E +YIV + M L L+S+ L D + F + ++Y Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ---LSNDHICYFLYQILRGLKY 157 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL------PVKWTAPEA- 357 + N +HRDL N+L++ K+ DFGL + A D + APE Sbjct: 158 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV------------------ 399 L K ++ D+WS G +L E+ S R +P D + + Sbjct: 218 LNSKGYTKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 276 Query: 400 -EKGYKMDAPDG--------CPPA---VYDVMKNCWHLDAATRPTFLQLREQ 439 + Y P P + D++ + R T + Sbjct: 277 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 328 >4BGQ-A nrPDB Length = 304 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 69/293 (23%), Positives = 123/293 (41%), Gaps = 54/293 (18%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIK----NDATAQAFLAEASVMTQLRH 245 M + ++L +G+G +G V+ ++ VA+K K N+ + L E ++ L+ Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+V+L +G LY+V EY+ K ++++ L V + + + + +A+ + Sbjct: 71 ENIVELKEAF-RRRGKLYLVFEYVEK-NMLELLEEMPNGV-PPEKVKSYIYQLIKAIHWC 127 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAPEALREK 361 N+ VHRD+ N+L+S ++V K+ DFG + S D + +PE L Sbjct: 128 HKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA 187 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-------------------- 401 + D+WS G +L E+ S G+ +P D + ++K Sbjct: 188 PYGKSVDMWSVGCILGEL-SDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFH 246 Query: 402 GYKMDAPDG-----------CPPAVYDVMKNCWHLDAATR---------PTFL 434 G + A + + D+MKN LD A R PTF Sbjct: 247 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >4CRS-A nrPDB Length = 341 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 60/276 (21%), Positives = 116/276 (42%), Gaps = 21/276 (7%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKN-----DATAQAFLAEA 237 + + N+++ + + +G FG V+L +Y+ A+K +K + + E Sbjct: 4 QQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEK 63 Query: 238 SVMT---QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 + +RH LV L + K + V EY A G L+ ++ + V + + Sbjct: 64 RIFETVNSVRHPFLVNLF-ACFQTKEHVCFVMEYAAGGDLMMHIHT---DVFSEPRAVFY 119 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQDTGKLPVK 351 + V ++YL + V+RDL N+L+ + K++DFGL KE T + Sbjct: 120 AACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPE 179 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC 411 + APE L E ++ D W G+L++E+ G P+P ++V + ++ P Sbjct: 180 FLAPEVLTETSYTRAVDWWGLGVLIYEML-VGESPFPGDDEEEVFDSIVND-EVRYPRFL 237 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 +M+ + R + + E ++ H Sbjct: 238 STEAISIMRRLLRRNPERRLGASE--KDAEDVKKHP 271 >3VN9-A nrPDB Length = 340 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 72/297 (24%), Positives = 122/297 (41%), Gaps = 29/297 (9%) Query: 167 LIKPKVMEGTVAAQDE-----FYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKV 219 +P+ D + + +L+ + +G+G +G V + G + Sbjct: 20 FEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIM 79 Query: 220 AVKCIK---NDATAQAFLAEASV-MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLV 275 AVK I+ N + L + + M + V G + E G ++I E M SL Sbjct: 80 AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE-GDVWICMELMD-TSLD 137 Query: 276 DYLRS--RGRSVLGGDCLLKFSLDVCEAMEYLEGN-NFVHRDLAARNVLVSEDNVAKVSD 332 + + + D L K ++ + +A+E+L + +HRD+ NVL++ K+ D Sbjct: 138 KFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 197 Query: 333 FG----LTKEASSTQDTGKLPVKWTAPE----ALREKKFSTKSDVWSFGILLWEIYSFGR 384 FG L + T D G P + APE L +K +S KSD+WS GI + E+ R Sbjct: 198 FGISGYLVDSVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-R 254 Query: 385 VPY--PRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 PY P + + VE+ D D C ++ RPT+ +L + Sbjct: 255 FPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 >3OHT-A nrPDB Length = 389 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 117/302 (38%), Gaps = 48/302 (15%) Query: 180 QDEFYRSGWALNMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATA----QAF 233 + E ++ W + + + L +G G +G V G K+AVK + + + Sbjct: 39 RQELNKTIWEVP-ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRT 97 Query: 234 LAEASVMTQLRHSNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 E ++ ++H N++ LL V EE +Y+VT M L + ++ + L Sbjct: 98 YRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNNIVKCQK---LTD 153 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL 348 D + + ++Y+ + +HRDL N+ V+ED K+ DFGL + Sbjct: 154 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 213 Query: 349 PVKWTAPEA-LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY---- 403 + APE L ++ D+WS G ++ E+ + GR +P + + ++ + Sbjct: 214 TRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLT-GRTLFPGTDHINQLQQIMRLTGTPP 272 Query: 404 -----KMDAPD---------------------GCPPAVYDVMKNCWHLDAATRPTFLQLR 437 +M + + G P D+++ LD R T + Sbjct: 273 ASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEAL 332 Query: 438 EQ 439 Sbjct: 333 AH 334 >1KOA-A nrPDB Length = 491 Score = 202 bits (514), Expect = 3e-52, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 115/277 (41%), Gaps = 21/277 (7%) Query: 181 DEFYRSGWALN----MKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCI--KNDATAQA 232 ++Y + + + + +G G FG V GN A K + +++ + Sbjct: 35 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 94 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 E M+ LRH LV L E+ + ++ E+M+ G L + + + + + D + Sbjct: 95 VRKEIQTMSVLRHPTLVNLHDAF-EDDNEMVMIYEFMSGGELFEKV-ADEHNKMSEDEAV 152 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVS--EDNVAKVSDFGLTKEASSTQD--TGKL 348 ++ VC+ + ++ NN+VH DL N++ + N K+ DFGLT Q Sbjct: 153 EYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTG 212 Query: 349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---GYKM 405 ++ APE K +D+WS G+L + + S G P+ + + V+ Sbjct: 213 TAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLS-GLSPFGGENDDETLRNVKSCDWNMDD 271 Query: 406 DAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 A G D ++ D TR T + + LEH Sbjct: 272 SAFSGISEDGKDFIRKLLLADPNTRMT---IHQALEH 305 >1ZWS-A nrPDB Length = 288 Score = 202 bits (514), Expect = 3e-52, Method: Composition-based stats. Identities = 50/266 (18%), Positives = 104/266 (39%), Gaps = 23/266 (8%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA--------QAFLAEASVMTQ 242 + + +G G+F V + G + A K IK + + E S++ Q Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ 71 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + H N++ L V E + + ++ E ++ G L D+L + L + F + + + Sbjct: 72 VLHHNVITLHDV-YENRTDVVLILELVSGGELFDFLAQKES--LSEEEATSFIKQILDGV 128 Query: 303 EYLEGNNFVHRDLAARNVLVSEDN----VAKVSDFGLTKEASSTQDTGKL--PVKWTAPE 356 YL H DL N+++ + N K+ DFGL E + + ++ APE Sbjct: 129 NYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPE 188 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---GYKMDAPDGCPP 413 + + ++D+WS G++ + + S G P+ ++ + + + + Sbjct: 189 IVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITSVSYDFDEEFFSHTSE 247 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQ 439 D ++ + R T + Sbjct: 248 LAKDFIRKLLVKETRKRLTIQEALRH 273 >5AWM-A nrPDB Length = 394 Score = 202 bits (514), Expect = 3e-52, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 113/310 (36%), Gaps = 62/310 (20%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI----KNDATAQAFLAEAS 238 + + ++ + + L + IG G G V VA+K + +N A+ E Sbjct: 37 DTNFTIHSRYINL-RPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFK 95 Query: 239 VMTQLRHSNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 293 +M + H N++ LL EE +Y+V E M +L ++ L D + Sbjct: 96 LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD----LDHDRMSY 150 Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST--QDTGKLPVK 351 + +++L +HRDL N++V D K+ DFGL + A +T + Sbjct: 151 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRY 210 Query: 352 WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---------- 401 + APE + ++ D+WS G ++ E+ G V +P D ++ + Sbjct: 211 YRAPEVILGMGYTENVDIWSVGCIMGEMIRGG-VLFPGTDHIDQWNKIIEQLGTPSPSFM 269 Query: 402 ------------------GYKMDA--PDGCPP------------AVYDVMKNCWHLDAAT 429 GY D PDG P +++ +D Sbjct: 270 QRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQ 329 Query: 430 RPTFLQLREQ 439 R + + + Sbjct: 330 RISVDEALKH 339 >2A27-A nrPDB Length = 321 Score = 202 bits (513), Expect = 4e-52, Method: Composition-based stats. Identities = 50/266 (18%), Positives = 104/266 (39%), Gaps = 23/266 (8%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA--------QAFLAEASVMTQ 242 + + +G G+F V + G + A K IK + + E S++ Q Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ 71 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + H N++ L V E + + ++ E ++ G L D+L + L + F + + + Sbjct: 72 VLHHNVITLHDV-YENRTDVVLILELVSGGELFDFLAQKES--LSEEEATSFIKQILDGV 128 Query: 303 EYLEGNNFVHRDLAARNVLVSEDN----VAKVSDFGLTKEASSTQDTGKL--PVKWTAPE 356 YL H DL N+++ + N K+ DFGL E + + ++ APE Sbjct: 129 NYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPE 188 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---GYKMDAPDGCPP 413 + + ++D+WS G++ + + S G P+ ++ + + + + Sbjct: 189 IVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITAVSYDFDEEFFSQTSE 247 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQ 439 D ++ + R T + Sbjct: 248 LAKDFIRKLLVKETRKRLTIQEALRH 273 >6J5U-C nrPDB Length = 426 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 127/307 (41%), Gaps = 39/307 (12%) Query: 176 TVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR-----------GNKVAVKCI 224 + F + K + +G+G FG V G G VAVK + Sbjct: 67 SSPNLKAFTFNELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQL 126 Query: 225 KNDATA--QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG 282 K + + +L E + + QL H NLV L+G E + L +V E+M KGSL ++L RG Sbjct: 127 KPEGFQGHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRRG 185 Query: 283 RSVLGGDCLLKFSLDVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKEAS 340 L +K ++ + + +L ++RD A N+L+ D AK+SDFGL K Sbjct: 186 AQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGP 245 Query: 341 STQDTGK-----LPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGR----------- 384 + +T + APE + + + KSDV+SFG++L E+ S R Sbjct: 246 TGDNTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEY 305 Query: 385 ------VPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 PY + + ++ P ++ C + DA RP ++ Sbjct: 306 SLVDWATPYLGDK-RKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVLV 364 Query: 439 QLEHIRT 445 LE + + Sbjct: 365 TLEQLES 371 >1KOB-A nrPDB Length = 387 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 109/261 (41%), Gaps = 17/261 (6%) Query: 193 KELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQA--FLAEASVMTQLRHSNL 248 +L+ +G G FG V G K I E S+M QL H L Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHHPKL 110 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 + L E+K + ++ E+++ G L D + + + ++ + CE ++++ + Sbjct: 111 INLHDAF-EDKYEMVLILEFLSGGELFDRIAAE-DYKMSEAEVINYMRQACEGLKHMHEH 168 Query: 309 NFVHRDLAARNVLV--SEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKFS 364 + VH D+ N++ + + K+ DFGL + + + ++ APE + + Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREPVG 228 Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---GYKMDAPDGCPPAVYDVMKN 421 +D+W+ G+L + + S G P+ + + V++ + DA P D +KN Sbjct: 229 FYTDMWAIGVLGYVLLS-GLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKN 287 Query: 422 CWHLDAATRPTFLQLREQLEH 442 + R T + + LEH Sbjct: 288 LLQKEPRKRLT---VHDALEH 305 >4AN9-A nrPDB Length = 301 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 63/257 (24%), Positives = 109/257 (42%), Gaps = 12/257 (4%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI---KNDATAQAFLAEASVMTQL 243 L + + + +G G G V ++ G +A K I A + E V+ + Sbjct: 5 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 64 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +V G + G + I E+M GSL L+ GR + L K S+ V + + Sbjct: 65 NSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLT 121 Query: 304 YL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-DTGKLPVKWTAPEALREK 361 YL E + +HRD+ N+LV+ K+ DFG++ + + + +PE L+ Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGT 181 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG-CPPAVYDVMK 420 +S +SD+WS G+ L E+ + GR P P + + +++ + P D + Sbjct: 182 HYSVQSDIWSMGLSLVEM-AVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVN 240 Query: 421 NCWHLDAATRPTFLQLR 437 C + A R QL Sbjct: 241 KCLIKNPAERADLKQLM 257 >5NGU-A nrPDB Length = 381 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 108/292 (36%), Gaps = 51/292 (17%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCI---KNDATAQAFLAEASVMTQLRHSNL 248 L IG+G +G V NKV A+K I ++ Q L E ++ + RH N+ Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 249 VQLLGVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 + + +I +E+ +YIV + M L L+++ L D + F + ++Y Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLME-TDLYKLLKTQH---LSNDHICYFLYQILRGLKY 158 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL------PVKWTAPEA- 357 + N +HRDL N+L++ K+ DFGL + A D + APE Sbjct: 159 IHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV------------------ 399 L K ++ D+WS G +L E+ S R +P D + + Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINL 277 Query: 400 -EKGYKMDAP-----------DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + Y + P D++ + R Q Sbjct: 278 KARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAH 329 >3MDY-A nrPDB Length = 337 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 78/298 (26%), Positives = 136/298 (45%), Gaps = 48/298 (16%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLA-EASVMTQLRHSNLVQL 251 K++++++ IGKG +G+V +G +RG KVAVK A F E +RH N++ Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 96 Query: 252 LGVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 + ++ G LY++T+Y GSL DYL+S + L +LK + + +L Sbjct: 97 IAADIKGTGSWTQLYLITDYHENGSLYDYLKS---TTLDAKSMLKLAYSSVSGLCHLHTE 153 Query: 309 --------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV-------KWT 353 HRDL ++N+LV ++ ++D GL + S + +P ++ Sbjct: 154 IFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYM 213 Query: 354 APEALREK------KFSTKSDVWSFGILLWE----IYSFG-----RVPY----PRIPLKD 394 PE L E + +D++SFG++LWE S G ++PY P P + Sbjct: 214 PPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYE 273 Query: 395 VVPRVE--KGYKMDAP-----DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 + + K + P D C + +M CW + A+R T L++++ L + Sbjct: 274 DMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSE 331 >5Z33-A nrPDB Length = 425 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 108/295 (36%), Gaps = 52/295 (17%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCI----KNDATAQAFLAEASVMTQLR-H 245 + + + +G+G +G V VA+K + A+ L E ++ R H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 246 SNLVQLLGVIVEEKGGL---YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 N+ L + + Y+ E M L +RS L F + + Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELME-CDLAAIIRS--GQPLTDAHFQSFIYQILCGL 147 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK------EASSTQDTGKLPVKW-TAP 355 +Y+ N +HRDL N+LV+ D K+ DFGL + E ++ T + +W AP Sbjct: 148 KYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAP 207 Query: 356 EA-LREKKFSTKSDVWSFGILLWEIYSFGRVPYPR---------------IPLKDVVPRV 399 E L + ++ DVWS G +L E+ GR + P ++ + R+ Sbjct: 208 EIMLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYVDQLNQILHILGTPNEETLSRI 266 Query: 400 EK------------GYKMDAPDGCP---PAVYDVMKNCWHLDAATRPTFLQLREQ 439 K P P P D++ D ++R + Q E Sbjct: 267 GSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEH 321 >2F9G-A nrPDB Length = 353 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 109/301 (36%), Gaps = 59/301 (19%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASVMTQLRHSN 247 + +L +G+G +G V ++ G VA+K I+ A L E ++ +H N Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 Query: 248 LVQLLGV----IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 ++ + + E +YI+ E M D R +L D + F A++ Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS-------------STQDTGKLPV 350 L G+N +HRDL N+L++ + KV DFGL + S Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 351 KWTAPEA-LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV---------- 399 + APE L K+S DVWS G +L E++ R +P + + + Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Query: 400 ----------EKGYKMDAP-----------DGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 + Y P P D+++ D A R T + E Sbjct: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 Query: 439 Q 439 Sbjct: 306 H 306 >1NY3-A nrPDB Length = 400 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 106/259 (40%), Gaps = 22/259 (8%) Query: 199 QTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEASVM-TQLRHSNLVQLLGVI 255 Q +G G G V + K A+K +++ A+ E + + ++V+++ V Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR---REVELHWRASQCPHIVRIVDVY 124 Query: 256 VE---EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 + L IV E + G L ++ RG + + EA++YL N H Sbjct: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 Query: 313 RDLAARNVLVSE---DNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALREKKFSTKS 367 RD+ N+L + + + K++DFG KE +S T + APE L +K+ Sbjct: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 244 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-----GYKMDAPD--GCPPAVYDVMK 420 D+WS G++++ + G P+ + P ++ Y+ P+ V +++ Sbjct: 245 DMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 303 Query: 421 NCWHLDAATRPTFLQLREQ 439 N + R T + Sbjct: 304 NLLKTEPTQRMTITEFMNH 322 >1JNK-A nrPDB Length = 423 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 108/302 (35%), Gaps = 60/302 (19%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI----KNDATAQAFLAEASVMTQLRH 245 +K + L+ IG G G V VA+K + +N A+ E +M + H Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 246 SNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 N++ LL V EE +Y+V E M +L ++ L + + + Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME----LDHERMSYLLYQMLC 175 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST--QDTGKLPVKWTAPEAL 358 +++L +HRDL N++V D K+ DFGL + A ++ + + APE + Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG-------- 410 + D+WS G ++ E+ ++ +P D +V + P+ Sbjct: 236 LGMGYKENVDIWSVGCIMGEMVRH-KILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 Query: 411 ------------------CPPAV---------------YDVMKNCWHLDAATRPTFLQLR 437 P ++ D++ +D A R + Sbjct: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 Query: 438 EQ 439 + Sbjct: 355 QH 356 >2BRG-A nrPDB Length = 297 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 107/260 (41%), Gaps = 17/260 (6%) Query: 193 KELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDAT---AQAFLAEASVMTQLRHSN 247 ++ L+QT+G+G +G+V L VAVK + + E + L H N Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHEN 66 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +V+ G E Y+ EY + G L D + + +F + + YL G Sbjct: 67 VVKFYG-HRREGNIQYLFLEYCSGGELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-----KLPVKWTAPEALREKK 362 HRD+ N+L+ E + K+SDFGL + + APE L+ ++ Sbjct: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRRE 183 Query: 363 F-STKSDVWSFGILLWEIYSFGRVPY--PRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 F + DVWS GI+L + + G +P+ P ++ EK ++ A ++ Sbjct: 184 FHAEPVDVWSCGIVLTAMLA-GELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + + R T +++ Sbjct: 243 HKILVENPSARITIPDIKKD 262 >6DTL-A nrPDB Length = 364 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 68/324 (20%), Positives = 114/324 (35%), Gaps = 49/324 (15%) Query: 168 IKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCI- 224 I + G Q + + + + K + IGKG +G V VA+K I Sbjct: 5 IPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIA 64 Query: 225 ---KNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE----KGGLYIVTEYMAKGSLVDY 277 N A+ L E ++ + H N+V + +I +YI E M L Sbjct: 65 NAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMD-TDLHQI 123 Query: 278 LRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 337 +RS L + F + ++Y+ N +HRDL N+L++ + K+ DFGL + Sbjct: 124 IRSN--QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR 181 Query: 338 EA--SSTQDTGKLPVKWTAPEALREKK-FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD 394 S + + APE L ++ DVWS G + E+ + +P Sbjct: 182 VTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM-DRKPLFPGRDHVH 240 Query: 395 VVPRVEK---------------------GYKMDAP-----DGCP---PAVYDVMKNCWHL 425 + + + P D P P D+++ Sbjct: 241 QLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTF 300 Query: 426 DAATRPTFLQLREQLEHIRTHELH 449 D R T + + L H + LH Sbjct: 301 DPRRRIT---VLDALAHPYLNSLH 321 >2XS0-A nrPDB Length = 386 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 107/302 (35%), Gaps = 60/302 (19%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI----KNDATAQAFLAEASVMTQLRH 245 +K + L+ IG G G V VA+K + +N A+ E +M + H Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 246 SNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 N++ LL V EE +YIV E M +L ++ L + + + Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQME----LDHERMSYLLYQMLC 139 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG--KLPVKWTAPEAL 358 +++L +HRDL N++V D K+ DFGL + A ++ + + APE + Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVI 199 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGC------- 411 + D+WS G ++ E+ G V +P D +V + P+ Sbjct: 200 LGMGYKENVDIWSVGCIMGEMIKGG-VLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTV 258 Query: 412 ----------------------------------PPAVYDVMKNCWHLDAATRPTFLQLR 437 D++ +DA+ R + + Sbjct: 259 RTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL 318 Query: 438 EQ 439 + Sbjct: 319 QH 320 >3FME-A nrPDB Length = 290 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 117/272 (43%), Gaps = 24/272 (8%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIK---NDATAQAFLAEASV-M 240 + +L+ + +G+G +G V + G +AVK I+ N + L + + M Sbjct: 1 SMEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 60 Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS--RGRSVLGGDCLLKFSLDV 298 + V G + E G ++I E M SL + + + D L K ++ + Sbjct: 61 RTVDCPFTVTFYGALFRE-GDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSI 118 Query: 299 CEAMEYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWT 353 +A+E+L + +HRD+ NVL++ K+ DFG L + + D G P + Sbjct: 119 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKP--YM 176 Query: 354 APE----ALREKKFSTKSDVWSFGILLWEIYSFGRVPY--PRIPLKDVVPRVEKGYKMDA 407 APE L +K +S KSD+WS GI + E+ R PY P + + VE+ Sbjct: 177 APERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEPSPQLP 235 Query: 408 PDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 D D C ++ RPT+ +L + Sbjct: 236 ADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 267 >2OZA-A nrPDB Length = 356 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 106/259 (40%), Gaps = 22/259 (8%) Query: 199 QTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEASVM-TQLRHSNLVQLLGVI 255 Q +G G G V + K A+K +++ A+ E + + ++V+++ V Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR---REVELHWRASQCPHIVRIVDVY 80 Query: 256 VE---EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 + L IV E + G L ++ RG + + EA++YL N H Sbjct: 81 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 140 Query: 313 RDLAARNVLVSE---DNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALREKKFSTKS 367 RD+ N+L + + + K++DFG KE +S T + APE L +K+ Sbjct: 141 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 200 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-----GYKMDAPD--GCPPAVYDVMK 420 D+WS G++++ + G P+ + P ++ Y+ P+ V +++ Sbjct: 201 DMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 259 Query: 421 NCWHLDAATRPTFLQLREQ 439 N + R T + Sbjct: 260 NLLKTEPTQRMTITEFMNH 278 >5LPZ-A nrPDB Length = 332 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 74/279 (26%), Positives = 129/279 (46%), Gaps = 31/279 (11%) Query: 195 LKLLQTIGKGEFGDVMLGDYR-GNKVAVKCIKN--DATAQAFLAEASVMTQLRHSNLVQL 251 IG G FGDV + G+ VA+K + + + F+AE + +++H NLV L Sbjct: 19 FHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPL 78 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS--VLGGDCLLKFSLDVCEAMEYLEGN- 308 LG L +V E+M GSL D L ++ L K ++ + +L N Sbjct: 79 LGYCKVGDERL-LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 309 --NFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAPEALREK 361 + +HRD+ + NVL+ E+ A+VSDFG+ + + + T + PE + Sbjct: 138 SPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSF 197 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVP--YPRIPLKDVVPRVEKGYKMDAPDGCPPAV---- 415 + STK DV+S+G++L E+ + G+ P P ++V V++ K+ D P + Sbjct: 198 RCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKED 256 Query: 416 ----YDVMKN------CWHLDAATRPTFLQLREQLEHIR 444 +++++ C A RPT +Q+ + I+ Sbjct: 257 PALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQ 295 >4FR4-A nrPDB Length = 384 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 58/284 (20%), Positives = 109/284 (38%), Gaps = 26/284 (9%) Query: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQA---- 232 + + +N ++L+ IGKG FG V + K A+K + + Sbjct: 1 SMPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVR 60 Query: 233 -FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCL 291 E +M L H LV L +++ +++V + + G L +L+ + + Sbjct: 61 NVFKELQIMQGLEHPFLVNLW-YSFQDEEDMFMVVDLLLGGDLRYHLQQNVH--FKEETV 117 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLP 349 F ++ A++YL+ +HRD+ N+L+ E ++DF + T Sbjct: 118 KLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGT 177 Query: 350 VKWTAPEALREKK---FSTKSDVWSFGILLWEIYSFGRVPY---PRIPLKDVVPRVEKGY 403 + APE +K +S D WS G+ +E+ GR PY K++V E Sbjct: 178 KPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELL-RGRRPYHIRSSTSSKEIVHTFETTV 236 Query: 404 KMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 + P + ++K + R + QL ++ Sbjct: 237 -VTYPSAWSQEMVSLLKKLLEPNPDQRFS------QLSDVQNFP 273 >3KA0-A nrPDB Length = 320 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 57/259 (22%), Positives = 106/259 (40%), Gaps = 22/259 (8%) Query: 199 QTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEASVM-TQLRHSNLVQLLGVI 255 Q +G G G V + K A+K +++ A+ E + + ++V+++ V Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR---REVELHWRASQCPHIVRIVDVY 78 Query: 256 VE---EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 + L IV E + G L ++ RG + + EA++YL N H Sbjct: 79 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 138 Query: 313 RDLAARNVLVSE---DNVAKVSDFGLTKEASSTQDTG--KLPVKWTAPEALREKKFSTKS 367 RD+ N+L + + + K++DFG KE +S + APE L +K+ Sbjct: 139 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPEKYDKSC 198 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVP----RVEKG-YKMDAPD--GCPPAVYDVMK 420 D+WS G++++ + G P+ + P R+ G Y+ P+ V +++ Sbjct: 199 DMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 257 Query: 421 NCWHLDAATRPTFLQLREQ 439 N + R T + Sbjct: 258 NLLKTEPTQRMTITEFMNH 276 >3FI2-A nrPDB Length = 353 Score = 198 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 108/302 (35%), Gaps = 60/302 (19%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI----KNDATAQAFLAEASVMTQLRH 245 +K + L+ IG G G V VA+K + +N A+ E +M + H Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 246 SNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 N++ LL V EE +Y+V E M +L ++ L + + + Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME----LDHERMSYLLYQMLC 137 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST--QDTGKLPVKWTAPEAL 358 +++L +HRDL N++V D K+ DFGL + A ++ + + APE + Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 197 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG-------- 410 + D+WS G ++ E+ ++ +P D +V + P+ Sbjct: 198 LGMGYKENVDIWSVGCIMGEMVRH-KILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 256 Query: 411 ------------------CPPAV---------------YDVMKNCWHLDAATRPTFLQLR 437 P ++ D++ +D A R + Sbjct: 257 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 316 Query: 438 EQ 439 + Sbjct: 317 QH 318 >3E7O-A nrPDB Length = 360 Score = 198 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 107/302 (35%), Gaps = 60/302 (19%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI----KNDATAQAFLAEASVMTQLRH 245 +K + L+ IG G G V G VAVK + +N A+ E ++ + H Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 246 SNLVQLLGVIV-----EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 N++ LL V EE +Y+V E M +L + L + + + Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHME----LDHERMSYLLYQMLC 135 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST--QDTGKLPVKWTAPEAL 358 +++L +HRDL N++V D K+ DFGL + AS+ + + APE + Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVI 195 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG---------------- 402 + D+WS G ++ E+ G V + D +V + Sbjct: 196 LGMGYKENVDIWSVGCIMGELV-KGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTV 254 Query: 403 --------------YKMDAPDGCPPA-----------VYDVMKNCWHLDAATRPTFLQLR 437 ++ PD P+ D++ +D R + + Sbjct: 255 RNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEAL 314 Query: 438 EQ 439 Sbjct: 315 RH 316 >5LPV-A nrPDB Length = 296 Score = 198 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 74/279 (26%), Positives = 129/279 (46%), Gaps = 31/279 (11%) Query: 195 LKLLQTIGKGEFGDVMLGDYR-GNKVAVKCIKN--DATAQAFLAEASVMTQLRHSNLVQL 251 IG G FGDV + G+ VA+K + + + F+AE + +++H NLV L Sbjct: 19 FHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPL 78 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS--VLGGDCLLKFSLDVCEAMEYLEGN- 308 LG L +V E+M GSL D L ++ L K ++ + +L N Sbjct: 79 LGYCKVGDERL-LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 309 --NFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKLPVKWTAPEALREK 361 + +HRD+ + NVL+ E+ A+VSDFG+ + + + T + PE + Sbjct: 138 SPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSF 197 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVP--YPRIPLKDVVPRVEKGYKMDAPDGCPPAV---- 415 + STK DV+S+G++L E+ + G+ P P ++V V++ K+ D P + Sbjct: 198 RCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKED 256 Query: 416 ----YDVMKN------CWHLDAATRPTFLQLREQLEHIR 444 +++++ C A RPT +Q+ + I+ Sbjct: 257 PALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQ 295 >6AMW-A nrPDB Length = 255 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 60/179 (33%), Positives = 87/179 (48%), Gaps = 11/179 (6%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 +A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ Sbjct: 85 FVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWAEAQTKNG-QGWVPSNYITPVNS--- 140 Query: 74 GTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY 133 L W+HG ++R AE LL G FLVRES + PG ++ + EG+V HYRI Sbjct: 141 ---LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINT 197 Query: 134 -HASKLSIDEEVYFENLMQLVEHYTTDADGLCT--RLIKPKVMEGTVAAQDEFYRSGWA 189 KL + E F L +LV H++T ADGL T PK + TV Y W Sbjct: 198 ASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY-DKWE 255 >6CTH-A nrPDB Length = 309 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 76/276 (27%), Positives = 123/276 (44%), Gaps = 29/276 (10%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKN--DATAQAFLAEASVMTQLRHSNL 248 +G+G FG V G R +AVK + + + +E ++++LRH NL Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHKNL 74 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 V+L+G E +G L +V E+MA GSL ++ +G+S+L + + D+ A+ YL Sbjct: 75 VKLIGWCHE-RGELMLVYEFMANGSLDSHI-FKGKSLLTWEVRYRIVKDLASALLYLHEE 132 Query: 309 N---FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL----PVKWTAPEALREK 361 +HRD+ N+++ AK+ DFGL + + K V + APE L Sbjct: 133 GDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSG 192 Query: 362 KFSTKSDVWSFGILLWEIYSFGR---VPYPRIPLKDVVPRVEKGYKMDAPDGC------- 411 K S +SDV+SFG++ EI S R + +VP V + Y + Sbjct: 193 KASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKLGM 252 Query: 412 ---PPAV-YDVMKNCWHLDAAT--RPTFLQLREQLE 441 P + VM W + RP+ Q+ + L Sbjct: 253 AFDPKQLECLVMVGLWCAHPSHNLRPSIRQVIQVLN 288 >3HKO-A nrPDB Length = 345 Score = 198 bits (503), Expect = 6e-51, Method: Composition-based stats. Identities = 67/326 (20%), Positives = 118/326 (36%), Gaps = 64/326 (19%) Query: 176 TVAAQDEFYRSGWALNM-KELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIKNDATAQ- 231 + ++ +++ G L + K+ L IG+G +G V + + A+K + + Q Sbjct: 8 SSGRENLYFQGGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQI 67 Query: 232 ------AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-----S 280 E +M +L H N+ +L V E++ + +V E G L+D L S Sbjct: 68 NPKDVERIKTEVRLMKKLHHPNIARLYEV-YEDEQYICLVMELCHGGHLLDKLNVFIDDS 126 Query: 281 RGRSVLG---------------------------------GDCLLKFSLDVCEAMEYLEG 307 G+ + + + A+ YL Sbjct: 127 TGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHN 186 Query: 308 NNFVHRDLAARNVLVSED--NVAKVSDFGLTKEA-------SSTQDTGKLPVKWTAPEAL 358 HRD+ N L S + K+ DFGL+KE T + APE L Sbjct: 187 QGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVL 246 Query: 359 R--EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK-MDAPDG--CPP 413 + + K D WS G+LL + G VP+P + D + +V + P+ P Sbjct: 247 NTTNESYGPKCDAWSAGVLL-HLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSP 305 Query: 414 AVYDVMKNCWHLDAATRPTFLQLREQ 439 D++ N + + R ++ + Sbjct: 306 LARDLLSNLLNRNVDERFDAMRALQH 331 >2BUJ-A nrPDB Length = 317 Score = 197 bits (502), Expect = 6e-51, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 27/290 (9%) Query: 183 FYRSGWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIK--NDATAQAFLAEAS 238 F ++ K +Q +G+G F V + G + G+ A+K I + EA Sbjct: 19 FQGHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREAD 78 Query: 239 VMTQLRHSNLVQLLGVIVEEKG---GLYIVTEYMAKGSLVDYLR--SRGRSVLGGDCLLK 293 + H N+++L+ + E+G +++ + +G+L + + + L D +L Sbjct: 79 MHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILW 138 Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL----------TKEASSTQ 343 L +C +E + + HRDL N+L+ ++ + D G +++A + Q Sbjct: 139 LLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQ 198 Query: 344 D--TGKLPVKWTAPEALREKKF---STKSDVWSFGILLWEIYSFGRVPYPRI--PLKDVV 396 D + + + APE + ++DVWS G +L+ + FG PY + V Sbjct: 199 DWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMM-FGEGPYDMVFQKGDSVA 257 Query: 397 PRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTH 446 V+ + A++ ++ + +D RP L QLE ++ Sbjct: 258 LAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPP 307 >1PY5-A nrPDB Length = 326 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 76/298 (25%), Positives = 135/298 (45%), Gaps = 48/298 (16%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLA-EASVMTQLRHSNLVQLLG 253 + L ++IGKG FG+V G +RG +VAVK + F E LRH N++ + Sbjct: 31 IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 90 Query: 254 VIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---- 306 ++ G L++V++Y GSL DYL R + + ++K +L + +L Sbjct: 91 ADNKDNGTWTQLWLVSDYHEHGSLFDYL---NRYTVTVEGMIKLALSTASGLAHLHMEIV 147 Query: 307 ----GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT-------GKLPVKWTAP 355 HRDL ++N+LV ++ ++D GL S DT ++ AP Sbjct: 148 GTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAP 207 Query: 356 EALREK------KFSTKSDVWSFGILLWEI---YSFG------RVPY----PRIPLKDVV 396 E L + + ++D+++ G++ WEI S G ++PY P P + + Sbjct: 208 EVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEM 267 Query: 397 PRV--EKGYKMDAP---DGCP--PAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 +V E+ + + P C + +M+ CW+ + A R T L++++ L + E Sbjct: 268 RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQE 325 >5UUU-A nrPDB Length = 547 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 53/255 (20%), Positives = 106/255 (41%), Gaps = 18/255 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQA-----FLAEASVMTQ 242 L M + + + IG+G FG+V G A+KC+ L E +++ Sbjct: 195 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 254 Query: 243 L---RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 + +V + L + + M G L +L G V + ++ ++ Sbjct: 255 VSTGDCPFIV-CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEII 311 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-PVKWTAPEAL 358 +E++ V+RDL N+L+ E ++SD GL + S + + + APE L Sbjct: 312 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 371 Query: 359 REK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV--VPRVEKGYKMDAPDGCPPAV 415 ++ + + +D +S G +L+++ G P+ + KD + R+ ++ PD P + Sbjct: 372 QKGVAYDSSADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 430 Query: 416 YDVMKNCWHLDAATR 430 +++ D R Sbjct: 431 RSLLEGLLQRDVNRR 445 >6BXI-A nrPDB Length = 333 Score = 195 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 57/317 (17%), Positives = 114/317 (35%), Gaps = 65/317 (20%) Query: 190 LNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQ-----AFLAEASVMTQ 242 L +++ + L+ IG+G FG+V L G+ A+K ++ + AE ++ + Sbjct: 3 LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE 62 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 +V++ ++K LY++ E++ G ++ L + L + + + A+ Sbjct: 63 ADSLWVVKMF-YSFQDKLNLYLIMEFLPGGDMMTLL--MKKDTLTEEETQFYIAETVLAI 119 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT----------------- 345 + + F+HRD+ N+L+ K+SDFGL T Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 346 ---------------------GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGR 384 + APE + ++ D WS G++++E+ G Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEML-IGY 238 Query: 385 VPYPRIPLKDVVPRVEK-GYKMDAPDGCP--PAVYDVMKN-CWHLDAATR---PTFLQLR 437 P+ ++ +V + P P D++ C R P +++ Sbjct: 239 PPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEW--EHRIGAPGVEEIK 296 Query: 438 E-------QLEHIRTHE 447 EHIR Sbjct: 297 SNSFFEGVDWEHIRERP 313 >3PVW-A nrPDB Length = 695 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 53/255 (20%), Positives = 106/255 (41%), Gaps = 18/255 (7%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQA-----FLAEASVMTQ 242 L M + + + IG+G FG+V G A+KC+ L E +++ Sbjct: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 Query: 243 L---RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 + +V + L + + M G L +L G V + ++ ++ Sbjct: 246 VSTGDCPFIV-CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEII 302 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-PVKWTAPEAL 358 +E++ V+RDL N+L+ E ++SD GL + S + + + APE L Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 Query: 359 REK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV--VPRVEKGYKMDAPDGCPPAV 415 ++ + + +D +S G +L+++ G P+ + KD + R+ ++ PD P + Sbjct: 363 QKGVAYDSSADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 Query: 416 YDVMKNCWHLDAATR 430 +++ D R Sbjct: 422 RSLLEGLLQRDVNRR 436 >4IC8-A nrPDB Length = 442 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 55/296 (18%), Positives = 107/296 (36%), Gaps = 53/296 (17%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKND----ATAQAFLAEASVMTQLRHS 246 E ++++TIG G +G V R G +VA+K I N A+ L E ++ +H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 247 NLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 N++ + ++ E +Y+V + M L + S L + + F + Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHS--SQPLTLEHVRYFLYQLLRG 171 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-------EASSTQDTGKLPVKWTA 354 ++Y+ +HRDL N+LV+E+ K+ DFG+ + E + A Sbjct: 172 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 231 Query: 355 PE-ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE------------- 400 PE L +++ D+WS G + E+ + ++ +P + + Sbjct: 232 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQL-FPGKNYVHQLQLIMMVLGTPSPAVIQA 290 Query: 401 ------KGYKMDAPDGCP-----------PAVYDVMKNCWHLDAATRPTFLQLREQ 439 + Y P P ++ + + R + Sbjct: 291 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRH 346 >4YHJ-A nrPDB Length = 584 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 52/259 (20%), Positives = 102/259 (39%), Gaps = 14/259 (5%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQA-----FLAE 236 + + + + +GKG FG+V G A K ++ + L E Sbjct: 176 WLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNE 235 Query: 237 ASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296 ++ +++ +V L E K L +V M G L ++ + G + ++ Sbjct: 236 KRILEKVQSRFVVSL-AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAA 294 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK--LPVKWTA 354 ++C +E L+ V+RDL N+L+ + ++SD GL E Q V + A Sbjct: 295 ELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMA 354 Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYK---MDAPDGC 411 PE + +K++ D W G L++E+ G P+ + K V++ K + + Sbjct: 355 PEVVNNEKYTFSPDWWGLGCLIYEMI-QGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKF 413 Query: 412 PPAVYDVMKNCWHLDAATR 430 + + + + R Sbjct: 414 SEDAKSICRMLLTKNPSKR 432 >5O2B-A nrPDB Length = 285 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 60/260 (23%), Positives = 107/260 (41%), Gaps = 19/260 (7%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVK------CIKNDATAQAFLAEASVMTQLRHSNL 248 LK +G+G F V G V V A Q F EA ++ L+H N+ Sbjct: 18 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 77 Query: 249 VQLLG---VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 V+ I++ K + +VTE M G+L YL+ V+ L + + + +++L Sbjct: 78 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQFL 135 Query: 306 EGN--NFVHRDLAARNVLVS-EDNVAKVSDFGLTKEA-SSTQDTGKLPVKWTAPEALREK 361 +HRDL N+ ++ K+ D GL +S + ++ APE E Sbjct: 136 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE- 194 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPDGCP-PAVYDVM 419 + DV++FG+ + E+ + PY + +V G K + + P V +++ Sbjct: 195 HYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEII 253 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + C + + R + L Sbjct: 254 EGCIRQNKSERLSIRDLLNH 273 >3MY0-A nrPDB Length = 305 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 125/302 (41%), Gaps = 52/302 (17%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLA-EASVMTQLRHSNLVQL 251 +++ L++ +GKG +G+V G + G VAVK + F E LRH N++ Sbjct: 8 RQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGF 67 Query: 252 LGVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE-- 306 + + + L+++T Y GSL D+L+ R L L+ ++ + +L Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQ---RQTLEPHLALRLAVSAACGLAHLHVE 124 Query: 307 ------GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-------TGKLPVKWT 353 HRD +RNVLV + ++D GL S D ++ Sbjct: 125 IFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYM 184 Query: 354 APEALREK------KFSTKSDVWSFGILLWEIYSF----G-----RVPYPRIPLKDVVPR 398 APE L E+ + +D+W+FG++LWEI G R P+ + D P Sbjct: 185 APEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPND--PS 242 Query: 399 VEKGYKMDAPDGCPPA-------------VYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 E K+ D P + +M+ CW+ + + R T L++++ L+ I Sbjct: 243 FEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISN 302 Query: 446 HE 447 Sbjct: 303 SP 304 >2ABL-A nrPDB Length = 163 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 56/158 (35%), Positives = 82/158 (51%), Gaps = 8/158 (5%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 +A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ Sbjct: 11 FVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITPVNS--- 66 Query: 74 GTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY 133 L W+HG ++R AE LL G FLVRES + PG ++ + EG+V HYRI Sbjct: 67 ---LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINT 123 Query: 134 -HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 KL + E F L +LV H++T ADGL T L P Sbjct: 124 ASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP 161 >4PWN-A nrPDB Length = 274 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 110/269 (40%), Gaps = 20/269 (7%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVK------CIKNDATAQAFLAEASVM 240 G + + + LK IG+G F V G V V + Q F EA ++ Sbjct: 4 GMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEML 63 Query: 241 TQLRHSNLVQLLGVIV---EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 L+H N+V+ + K + +VTE M G+L YL+ V+ L + Sbjct: 64 KGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR--FKVMKIKVLRSWCRQ 121 Query: 298 VCEAMEYLEGN--NFVHRDLAARNVLVS-EDNVAKVSDFGLTK--EASSTQDTGKLPVKW 352 + + +++L +HRDL N+ ++ K+ D GL + +S + ++ Sbjct: 122 ILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEF 181 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPDGC 411 APE EK + DV++FG+ + E+ + PY + RV G K + D Sbjct: 182 MAPEMYEEK-YDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRRVTSGVKPASFDKV 239 Query: 412 P-PAVYDVMKNCWHLDAATRPTFLQLREQ 439 P V ++++ C + R + L Sbjct: 240 AIPEVKEIIEGCIRQNKDERYSIKDLLNH 268 >5O2C-A nrPDB Length = 380 Score = 194 bits (494), Expect = 6e-50, Method: Composition-based stats. Identities = 60/260 (23%), Positives = 107/260 (41%), Gaps = 19/260 (7%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVK------CIKNDATAQAFLAEASVMTQLRHSNL 248 LK +G+G F V G V V A Q F EA ++ L+H N+ Sbjct: 27 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 86 Query: 249 VQLLG---VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 V+ I++ K + +VTE M G+L YL+ V+ L + + + +++L Sbjct: 87 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQFL 144 Query: 306 EGN--NFVHRDLAARNVLVS-EDNVAKVSDFGLTKEA-SSTQDTGKLPVKWTAPEALREK 361 +HRDL N+ ++ K+ D GL +S + ++ APE E Sbjct: 145 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE- 203 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPDGCP-PAVYDVM 419 + DV++FG+ + E+ + PY + +V G K + + P V +++ Sbjct: 204 HYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEII 262 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + C + + R + L Sbjct: 263 EGCIRQNKSERLSIRDLLNH 282 >4C59-A nrPDB Length = 340 Score = 193 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 117/304 (38%), Gaps = 40/304 (13%) Query: 175 GTVAAQDEFYRSGWALNMKELKLL--QTIGKGEFGDVMLGDY--RGNKVAVKCI--KNDA 228 G + +D+ G + + EL+L + + +G F V G + A+K + + Sbjct: 7 GGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEE 66 Query: 229 TAQAFLAEASVMTQLR-HSNLVQLLGVIV-------EEKGGLYIVTEYMAKGSLVDYLRS 280 +A + E M +L H N+VQ + ++TE KG LV++L+ Sbjct: 67 KNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELC-KGQLVEFLKK 125 Query: 281 RG-RSVLGGDCLLKFSLDVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTK 337 R L D +LK C A++++ +HRDL N+L+S K+ DFG Sbjct: 126 MESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSAT 185 Query: 338 EASSTQD---------------TGKLPVKWTAPEAL---REKKFSTKSDVWSFGILLWEI 379 S D T + PE + K D+W+ G +L+ + Sbjct: 186 TISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILY-L 244 Query: 380 YSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 F + P+ + V Y + D + +++ ++ R + ++ Q Sbjct: 245 LCFRQHPFED---GAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQ 301 Query: 440 LEHI 443 L+ I Sbjct: 302 LQEI 305 >4O2Z-A nrPDB Length = 377 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 112/301 (37%), Gaps = 50/301 (16%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVK----CIKNDATAQAFLAEASVMTQLRHS 246 + LL+ +G G +G G KV++K ++ + L E +M H Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHE 104 Query: 247 NLVQLLGVI------VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 NL+ ++ ++ +Y+VT M + + R R VL + F + Sbjct: 105 NLLNVVNILPPLKREYHSFEDVYVVTPLM---DVDMNVVLRSRQVLEESHMQYFVYQILR 161 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEA 357 ++YL N HRDL N++ + K+ DFGL++ S + + PE Sbjct: 162 GLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPEL 221 Query: 358 LREK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV----------------- 399 L E +ST D+WS G + E+Y+ + +P D + + Sbjct: 222 LLENTNYSTAVDIWSVGCIFAEMYN-RKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREA 280 Query: 400 -EKGYKMD-----APDGCP-----PAVYDVMKNCWHLDAATRPTFLQLREQ--LEHIRTH 446 EK ++ P P D + W LD + RPT + L H+ Sbjct: 281 LEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDE 340 Query: 447 E 447 E Sbjct: 341 E 341 >3LM0-A nrPDB Length = 327 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 56/288 (19%), Positives = 115/288 (39%), Gaps = 30/288 (10%) Query: 182 EFYRSGWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQ----AFLA 235 E + + + L KE +G+G+F V + G + A K +K Q L Sbjct: 24 ENFNNFYILTSKE------LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILH 77 Query: 236 EASVMTQLRH-SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 E +V+ + ++ L V E + ++ EY A G + ++ + +++ Sbjct: 78 EIAVLELAKSCPRVINLHEV-YENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRL 136 Query: 295 SLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEASSTQDTGKL--P 349 + E + YL NN VH DL +N+L+S K+ DFG++++ + ++ Sbjct: 137 IKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGT 196 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK---GYKMD 406 ++ APE L +T +D+W+ GI+ + + + P+ ++ + + Y + Sbjct: 197 PEYLAPEILNYDPITTATDMWNIGIIAYMLLTH-TSPFVGEDNQETYLNISQVNVDYSEE 255 Query: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ-------LEHIRTHE 447 D +++ + RPT E++ E Sbjct: 256 TFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPE 303 >2HW6-A nrPDB Length = 307 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 55/283 (19%), Positives = 107/283 (37%), Gaps = 47/283 (16%) Query: 199 QTIGKGEFGDV--MLGDYRGNKVAVKCIKNDA--TAQAFLAEASVMTQLR-HSNLVQLLG 253 + +G+G + V + G + AVK I+ A + E + Q + + N+++L+ Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIE 78 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 E+ Y+V E + GS++ +++ + + DV A+++L HR Sbjct: 79 -FFEDDTRFYLVFEKLQGGSILAHIQKQKH--FNEREASRVVRDVAAALDFLHTKGIAHR 135 Query: 314 DLAARNVLVSEDNV---AKVSDFGLTKEASSTQD----------TGKLPVKWTAPEAL-- 358 DL N+L K+ DF L T ++ APE + Sbjct: 136 DLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEV 195 Query: 359 ---REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD---------------VVPRVE 400 + + + D+WS G++L+ + S G P+ D + ++ Sbjct: 196 FTDQATFYDKRCDLWSLGVVLYIMLS-GYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 254 Query: 401 KGYKMDAPD----GCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 +G K + PD D++ DA R + Q+ + Sbjct: 255 EG-KYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQH 296 >2A1A-B nrPDB Length = 284 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 50/276 (18%), Positives = 105/276 (38%), Gaps = 32/276 (11%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQ 242 + ++ KE++L IG G FG V +R G +K +K + E + + Sbjct: 6 DKRFGMDFKEIEL---IGSGGFGQVFKAKHRIDGKTYVIKRVK--YNNEKAEREVKALAK 60 Query: 243 LRHSNLVQLLGVI---------------VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG 287 L H N+V G + L+I E+ KG+L ++ R L Sbjct: 61 LDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLD 120 Query: 288 GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL--TKEASSTQDT 345 L+ + + ++Y+ ++RDL N+ + + K+ DFGL + + + Sbjct: 121 KVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTR 180 Query: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLK-DVVPRVEKGYK 404 K +++ +PE + + + + D+++ G++L E+ + D+ + Sbjct: 181 SKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGI----- 235 Query: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 D +++ RP ++ L Sbjct: 236 --ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTL 269 >3ORP-A nrPDB Length = 311 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 111/275 (40%), Gaps = 25/275 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQ-----AFLAEASVMTQLRH 245 +L + +G G +V L VAVK ++ D F EA L H Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 246 SNLVQLL--GVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 +V + G G L YIV EY+ +L D + + G + ++ D C+A+ Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG--PMTPKRAIEVIADACQAL 129 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK------LPVKWTAPE 356 + N +HRD+ N+++S N KV DFG+ + + + ++ ++ +PE Sbjct: 130 NFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE 189 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV-VPRVEKGYKMD--APDGCPP 413 R +SDV+S G +L+E+ + G P+ V V + +G Sbjct: 190 QARGDSVDARSDVYSLGCVLYEVLT-GEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSA 248 Query: 414 AVYDVMKNCWHLDAATRP-TFLQLREQLEHIRTHE 447 + V+ + R T ++R L +R H Sbjct: 249 DLDAVVLKALAKNPENRYQTAAEMRADL--VRVHN 281 >5Y86-A nrPDB Length = 588 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 50/232 (21%), Positives = 96/232 (41%), Gaps = 14/232 (6%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDATAQA-FLAEASVMTQLRHS---- 246 ++L+ IGKG FG V VA+K ++N+ E ++ L+ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Query: 247 --NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 N++ +L + + + E ++ L + ++ + KF+ + ++++ Sbjct: 268 SMNVIHMLESFT-FRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 Query: 305 LEGNNFVHRDLAARNVLVSEDN--VAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKK 362 L N +H DL N+L+ KV DFG + T + APE + + Sbjct: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSR 385 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414 +ST D+WSFG +L E+ + G+ +P D + + + M P + Sbjct: 386 YSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKLLEQS 436 >4ZSG-A nrPDB Length = 347 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 55/296 (18%), Positives = 107/296 (36%), Gaps = 53/296 (17%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKND----ATAQAFLAEASVMTQLRHS 246 E ++++TIG G +G V R G +VA+K I N A+ L E ++ +H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 247 NLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 N++ + ++ E +Y+V + M L + S L + + F + Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHS--SQPLTLEHVRYFLYQLLRG 123 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-------EASSTQDTGKLPVKWTA 354 ++Y+ +HRDL N+LV+E+ K+ DFG+ + E + A Sbjct: 124 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 183 Query: 355 PE-ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE------------- 400 PE L +++ D+WS G + E+ + ++ +P + + Sbjct: 184 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQL-FPGKNYVHQLQLIMMVLGTPSPAVIQA 242 Query: 401 ------KGYKMDAPDGCP-----------PAVYDVMKNCWHLDAATRPTFLQLREQ 439 + Y P P ++ + + R + Sbjct: 243 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRH 298 >4QNY-A nrPDB Length = 354 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 109/299 (36%), Gaps = 52/299 (17%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR---GNKVAVKCIKNDATAQ-----AFLAEASVMTQLR 244 L + IG G +G V+ VA+K + + + L E ++ Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFN 79 Query: 245 HSNLVQLLGVIVEEK----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 N++ L ++ E YIV + M L LRS L + F Sbjct: 80 DDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLRS--GQELTEAHIQFFIYQALR 136 Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKW-TAPE- 356 A+ + +HRD+ N+LV+ + K+ DFGL KE + T + ++W APE Sbjct: 137 ALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 357 ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV----------------- 399 + +K +S + DVW G +L E+ R + + + ++ Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELL-GSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGS 255 Query: 400 --------EKGYKMDAP-----DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ--LEHI 443 +K ++ A P D++++ + R T LQ LE + Sbjct: 256 SAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQL 314 >1ZXE-A nrPDB Length = 303 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 56/279 (20%), Positives = 102/279 (36%), Gaps = 34/279 (12%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKN-DATAQAFLAEASVMTQLRHSNLV 249 + + + +G+G FG V+ A+K I++ + L+E ++ L H +V Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVV 65 Query: 250 QLLGVIVEEKGG------------LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 + +E + L+I EY +L D + S + D + Sbjct: 66 RYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQ-QRDEYWRLFRQ 124 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--------- 348 + EA+ Y+ +HR+L N+ + E K+ DFGL K + D KL Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 349 --------PVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 + A E L ++ K D++S GI+ +E+ R+ + + V Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILKKLRSV 244 Query: 400 EKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 + D D +++ D RP L Sbjct: 245 SIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLN 283 >5G6V-A nrPDB Length = 324 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 59/217 (27%), Positives = 106/217 (48%), Gaps = 13/217 (5%) Query: 192 MKELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQA---FLAEASVMTQLRHS 246 M+ L +G+G + V G N VA+K I+ + A + E S++ L+H+ Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 60 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 N+V L +I EK L +V EY+ K L YL G +++ + F + + Y Sbjct: 61 NIVTLHDIIHTEKS-LTLVFEYLDK-DLKQYLDDCG-NIINMHNVKLFLFQLLRGLAYCH 117 Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---STQDTGKLPVKWTAPEALREK-K 362 +HRDL +N+L++E K++DFGL + S T D + + + P+ L Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTD 177 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 +ST+ D+W G + +E+ + GR +P +++ + + Sbjct: 178 YSTQIDMWGVGCIFYEMAT-GRPLFPGSTVEEQLHFI 213 >3OZ6-A nrPDB Length = 388 Score = 192 bits (487), Expect = 4e-49, Method: Composition-based stats. Identities = 62/327 (18%), Positives = 115/327 (35%), Gaps = 84/327 (25%) Query: 192 MKELKLLQTIGKGEFGDVML--GDYRGNKVAVKCI----KNDATAQAFLAEASVMTQLR- 244 +++ +L++ +GKG +G V G VAVK I +N AQ E ++T+L Sbjct: 8 LRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 245 HSNLVQLLGVIVEEKG-GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 H N+V LL V+ + +Y+V +YM L +R+ +L + + ++ Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYME-TDLHAVIRAN---ILEPVHKQYVVYQLIKVIK 123 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--------------- 348 YL +HRD+ N+L++ + KV+DFGL++ + + Sbjct: 124 YLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDD 183 Query: 349 ---------PVKWTAPEALREK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 + APE L K++ D+WS G +L EI G+ +P + + R Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILC-GKPIFPGSSTMNQLER 242 Query: 399 VEKGYKMDAPD----------------------------------------------GCP 412 + + + C Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302 Query: 413 PAVYDVMKNCWHLDAATRPTFLQLREQ 439 D++ + R + + Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKH 329 >5USZ-A nrPDB Length = 289 Score = 192 bits (487), Expect = 4e-49, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 129/279 (46%), Gaps = 25/279 (8%) Query: 190 LNMKELKLLQTIGKGEFGDVMLG---------DYRGNKVAVKCIKN--DATAQAFLAEAS 238 + ++L +++G+G F + G +V +K + +++F AS Sbjct: 5 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAAS 64 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 +M++L H +LV GV V + +V E++ GSL YL+ + ++ + L+ + + Sbjct: 65 MMSKLSHKHLVLNYGVCVCGDENI-LVQEFVKFGSLDTYLK-KNKNCINILWKLEVAKQL 122 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNV--------AKVSDFGLTKEASSTQDTGKLPV 350 AM +LE N +H ++ A+N+L+ + K+SD G++ +D + + Sbjct: 123 AAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP-KDILQERI 181 Query: 351 KWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD 409 W PE + K + +D WSFG LWEI S G P + + + E +++ AP Sbjct: 182 PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPK 241 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHEL 448 + +++ NC + RP+F + L + T +L Sbjct: 242 A--AELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPDL 278 >2VD5-A nrPDB Length = 412 Score = 191 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 50/267 (18%), Positives = 105/267 (39%), Gaps = 26/267 (9%) Query: 186 SGWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKN-----DATAQAFLAEAS 238 L + ++L+ IG+G F +V + G A+K + F E Sbjct: 54 KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERD 113 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 V+ + QL +++ LY+V EY G L+ L S+ + + + ++ Sbjct: 114 VLVNGDRRWITQLH-FAFQDENYLYLVMEYYVGGDLLTLL-SKFGERIPAEMARFYLAEI 171 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKWTA 354 A++ + +VHRD+ N+L+ +++DFG L + + + + Sbjct: 172 VMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLS 231 Query: 355 PEALR-------EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV---EKGYK 404 PE L+ + + D W+ G+ +E++ +G+ P+ + ++ ++ Sbjct: 232 PEILQAVGGGPGTGSYGPECDWWALGVFAYEMF-YGQTPFYADSTAETYGKIVHYKEHLS 290 Query: 405 MDAPD-GCPPAVYDVMKNCWHLDAATR 430 + D G P D ++ TR Sbjct: 291 LPLVDEGVPEEARDFIQRLLCP-PETR 316 >5AIR-A nrPDB Length = 430 Score = 190 bits (484), Expect = 8e-49, Method: Composition-based stats. Identities = 66/334 (19%), Positives = 116/334 (34%), Gaps = 56/334 (16%) Query: 159 DADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RG 216 D DG + +G Q+ Y + IG G FG V G Sbjct: 41 DKDGSKVTTVVATPGQGPDRPQEVSYTDT-----------KVIGNGSFGVVYQAKLCDSG 89 Query: 217 NKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV---EEKGGLYI--VTEYMAK 271 VA+K + D + E +M +L H N+V+L E+K +Y+ V +Y+ + Sbjct: 90 ELVAIKKVLQDKRFKN--RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE 147 Query: 272 GSLV-DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA-K 329 SR + L + + + ++ Y+ HRD+ +N+L+ D K Sbjct: 148 TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLK 207 Query: 330 VSDFGLTKEASSTQDTGKL--PVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVP 386 + DFG K+ + + APE + +++ DVWS G +L E+ G+ Sbjct: 208 LCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQPI 266 Query: 387 YPRI---------------PLKDVVPRVEKGY-KMDAP------------DGCPPAVYDV 418 +P P ++ + + Y + P PP + Sbjct: 267 FPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL 326 Query: 419 MKNCWHLDAATRPTFLQ--LREQLEHIRTHELHL 450 R T L+ + +R + L Sbjct: 327 CSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL 360 >6CCF-A nrPDB Length = 290 Score = 190 bits (484), Expect = 8e-49, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 116/288 (40%), Gaps = 42/288 (14%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCI----------------------- 224 + + + KL IGKG +G V L A+K + Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 225 -----KNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE-KGGLYIVTEYMAKGSLVDYL 278 K + E +++ +L H N+V+L+ V+ + + LY+V + + KG +++ Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV- 120 Query: 279 RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 + + DV +EYL VHRD+ N+L+ +D K++DFG++ + Sbjct: 121 --PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ 178 Query: 339 ASSTQ---DTGKLPVKWTAPEAL--REKKFSTKS-DVWSFGILLWEIYSFGRVPYPRIPL 392 + + APEA+ + FS K+ DVW+ G+ L+ + +G+ P+ + Sbjct: 179 FEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLY-CFVYGKCPFIDDFI 237 Query: 393 KDVVPRVE-KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + +++ + + D++ + TR ++ Sbjct: 238 LALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLH 285 >5B2L-A nrPDB Length = 324 Score = 190 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 119/271 (43%), Gaps = 21/271 (7%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASV- 239 + + +L+ L +G G G V +R G+ +AVK ++ N + L + V Sbjct: 10 QRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVV 69 Query: 240 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 + +VQ G + ++I E M G+ + L+ R + + L K ++ + Sbjct: 70 LKSHDCPYIVQCFGTFITNTD-VFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIV 126 Query: 300 EAMEYL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP--VKWTAPE 356 +A+ YL E + +HRD+ N+L+ E K+ DFG++ ++ + + APE Sbjct: 127 KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPE 186 Query: 357 AL-----REKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAP-- 408 + + + ++DVWS GI L E+ + G+ PY +V+ +V + P Sbjct: 187 RIDPPDPTKPDYDIRADVWSLGISLVELAT-GQFPYKNCKTDFEVLTKVLQEEPPLLPGH 245 Query: 409 DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 G +K+C D RP + +L E Sbjct: 246 MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEH 276 >2WTK-C nrPDB Length = 305 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 61/262 (23%), Positives = 108/262 (41%), Gaps = 19/262 (7%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIKNDATAQ------AFLAEASVMTQLRH 245 + + +G+G +G V AVK +K + E ++ +LRH Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 246 SNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 N++QL+ V+ EEK +Y+V EY G + + L S + + + +EY Sbjct: 66 KNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLIDGLEY 124 Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-----TQDTGKLPVKWTAPEALR 359 L VH+D+ N+L++ K+S G+ + T T + + PE Sbjct: 125 LHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIAN 184 Query: 360 EKK--FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 K D+WS G+ L+ I + G P+ + + + KG P C P + D Sbjct: 185 GLDTFSGFKVDIWSAGVTLYNI-TTGLYPFEGDNIYKLFENIGKG-SYAIPGDCGPPLSD 242 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 ++K + A R + Q+R+ Sbjct: 243 LLKGMLEYEPAKRFSIRQIRQH 264 >3MIA-A nrPDB Length = 351 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 118/300 (39%), Gaps = 53/300 (17%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLR 244 + + + L IG+G FG+V +R G KVA+K + + + F L E ++ L+ Sbjct: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 Query: 245 HSNLVQLLGVIVEE-------KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 H N+V L+ + + KG +Y+V ++ L L S + + Sbjct: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLL-SNVLVKFTLSEIKRVMQM 132 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-------TGKLPV 350 + + Y+ N +HRD+ A NVL++ D V K++DFGL + S ++ + + Sbjct: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 Query: 351 KWTAPEALREKK-FSTKSDVWSFGILLWEI---------------------YSFGRVP-- 386 + PE L ++ + D+W G ++ E+ P Sbjct: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Query: 387 YPRIPLKDVVPRVE--KGYKMDAPDGC-----PPAVYDVMKNCWHLDAATRPTFLQLREQ 439 +P + ++ ++E KG K D P D++ LD A R Sbjct: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 >4RT7-A nrPDB Length = 415 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 81/215 (37%), Positives = 115/215 (53%), Gaps = 21/215 (9%) Query: 235 AEASVMTQLRHSN---LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCL 291 E + H + + L G + + EY + L + +VL + L Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEI----EYENQKRLEE---EEDLNVLTFEDL 245 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TG 346 L F+ V + ME+LE + VHRDLAARNVLV+ V K+ DFGL ++ S + Sbjct: 246 LCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNA 305 Query: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP-LKDVVPRVEKGYKM 405 +LPVKW APE+L E ++ KSDVWS+GILLWEI+S G PYP IP + ++ G+KM Sbjct: 306 RLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKM 365 Query: 406 DAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 D P +Y +M++CW D+ RP+F L L Sbjct: 366 DQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 400 Score = 99 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 12/111 (10%) Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDA---TAQAF 233 Y W + L+ + +G G FG VM G +VAVK +K A +A Sbjct: 56 YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 115 Query: 234 LAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR 283 ++E +MTQL H N+V LLG G +Y++ EY G L++YLRS+ Sbjct: 116 MSELKMMTQLGSHENIVNLLGACT-LSGPIYLIFEYCCYGDLLNYLRSKRE 165 >3UIU-A nrPDB Length = 306 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 50/289 (17%), Positives = 105/289 (36%), Gaps = 45/289 (15%) Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQ 242 + ++ KE++L IG G FG V +R G ++ +K + E + + Sbjct: 7 DKRFGMDFKEIEL---IGSGGFGQVFKAKHRIDGKTYVIRRVK--YNNEKAEREVKALAK 61 Query: 243 LRHSNLVQLLGVI----------------------------VEEKGGLYIVTEYMAKGSL 274 L H N+V G + L+I E+ KG+L Sbjct: 62 LDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTL 121 Query: 275 VDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG 334 ++ R L L+ + + ++Y+ +HRDL N+ + + K+ DFG Sbjct: 122 EQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFG 181 Query: 335 L--TKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392 L + + + K +++ +PE + + + + D+++ G++L E+ + Sbjct: 182 LVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKF 241 Query: 393 K-DVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQL 440 D+ + D +++ RP ++ L Sbjct: 242 FTDLRDGI-------ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTL 283 >4MWI-A nrPDB Length = 294 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 117/279 (41%), Gaps = 31/279 (11%) Query: 191 NMKELKLLQTIG-------KGEFGDVMLGDYRGNKVAVKCIKNDA------TAQAFLAEA 237 +KE+K Q G + E + G+Y VA+K K Q F E Sbjct: 15 QIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEI 74 Query: 238 SVMTQLRHSNLVQLLGVIVEE---KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF 294 M + N++++ G+ ++E IV EY G+L + L LG +L Sbjct: 75 KTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVL-- 132 Query: 295 SLDVCEAMEYLE--GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-------TQDT 345 L + L +H + + N LV++ K++ F L K +S + Sbjct: 133 VLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTD 192 Query: 346 GKLPVKWTAPEALRE--KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KG 402 + +P+ L + ++ KS+++SFGI+LWEI + G +P+ + + V K Sbjct: 193 RVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAVKR 251 Query: 403 YKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 + + CP + +++ C D + RP+ ++ ++L Sbjct: 252 QQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLS 290 >4M7I-A nrPDB Length = 299 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 61/284 (21%), Positives = 114/284 (40%), Gaps = 45/284 (15%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCIK---NDATAQAFLAEASVMTQLRHS 246 + + + +Q +G+G FG V + + A+K I+ + + + E + +L H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHP 63 Query: 247 NLVQLLGVIVEEKG-----------GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCL---L 292 +V+ +E+ LYI + K +L D++ GR + L Sbjct: 64 GIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM--NGRCTIEERERSVCL 121 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL--TKEASSTQDTGKLPV 350 L + EA+E+L +HRDL N+ + D+V KV DFGL + + T P+ Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 181 Query: 351 K-------------WTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVP 397 + +PE + +S K D++S G++L+E+ YP + V Sbjct: 182 PAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL------YPFSTQMERVR 235 Query: 398 RVEKGYKMDAPDGCP---PAVYDVMKNCWHLDAATRPTFLQLRE 438 + + P P Y ++++ RP + + E Sbjct: 236 TLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIE 279 >5TE0-A nrPDB Length = 347 Score = 187 bits (476), Expect = 8e-48, Method: Composition-based stats. Identities = 56/286 (19%), Positives = 114/286 (39%), Gaps = 30/286 (10%) Query: 176 TVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGD-YRGNKVAVKC--IKNDATAQA 232 T + + + +++ + + + +G F V L G K A+K + N+ Q Sbjct: 2 TSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQV 61 Query: 233 FLAEASVMTQLR-HSNLVQLLGVIVEE--KGGLY---IVTEYMAKGSLVDYLRSRGRSVL 286 E +M L H N+V + + G ++ I+ ++ G +V+ + R ++ Sbjct: 62 CKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGF 121 Query: 287 GGDCLLKFSLDVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD 344 + +L+ D CEA+ L +HRDL N+L+ + + DFG Sbjct: 122 TENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ 181 Query: 345 T-----------GKLPVKWTAPEALR---EKKFSTKSDVWSFGILLWEIYSFGRVPYPRI 390 T + + APE + K +TK+D+W+ G LL+++ F +P+ Sbjct: 182 TEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYF-TLPFG-- 238 Query: 391 PLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 + V + + + ++ +++ D RP Q+ Sbjct: 239 --ESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >4M69-B nrPDB Length = 283 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 111/265 (41%), Gaps = 22/265 (8%) Query: 200 TIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQ------AFLAEASVMTQLRHSNLVQLLG 253 + + + G+Y + V +K N F E M + N++++ G Sbjct: 16 KLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFG 75 Query: 254 VIVEE---KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 + +++ IV EY G+L + L + LL + L + Sbjct: 76 ICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRA--ARGLYRLHHSET 133 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKWTAPEALRE--K 361 +HR++++ + LV+ K++ F L+K +S T K + +PE L+ Sbjct: 134 LHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFC 193 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-EKGYKMDAPDGCPPAVYDVMK 420 + K++++SFGI+LWEI + G++P+ K + V E + CP + +++ Sbjct: 194 LYDIKAEIYSFGIVLWEIAT-GKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIIN 252 Query: 421 NCWHLDAATRPTFLQLREQLEHIRT 445 C + + RP+ + E+L + Sbjct: 253 ECRAHEPSQRPSVDGILERLSAVEE 277 >4BTF-A nrPDB Length = 469 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 111/265 (41%), Gaps = 22/265 (8%) Query: 200 TIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQ------AFLAEASVMTQLRHSNLVQLLG 253 + + + G+Y + V +K N F E M + N++++ G Sbjct: 202 KLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFG 261 Query: 254 VIVEE---KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 + +++ IV EY G+L + L + LL + L + Sbjct: 262 ICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRA--ARGLYRLHHSET 319 Query: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP-------VKWTAPEALRE--K 361 +HR++++ + LV+ K++ F L+K +S T K + +PE L+ Sbjct: 320 LHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFC 379 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-EKGYKMDAPDGCPPAVYDVMK 420 + K++++SFGI+LWEI + G++P+ K + V E + CP + +++ Sbjct: 380 LYDIKAEIYSFGIVLWEIAT-GKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIIN 438 Query: 421 NCWHLDAATRPTFLQLREQLEHIRT 445 C + + RP+ + E+L + Sbjct: 439 ECRAHEPSQRPSVDGILERLSAVEE 463 >6GVJ-A nrPDB Length = 429 Score = 185 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 124/281 (44%), Gaps = 32/281 (11%) Query: 195 LKLLQTIGKGEFGDVMLG-DYRGNKVAVKCIKNDATAQAFL----AEASVMTQLR-HSN- 247 +L+ IG G V + + A+K + + L E + + +L+ HS+ Sbjct: 146 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 205 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +++L + ++ +Y+V E L +L+ + + + ++ EA+ + Sbjct: 206 IIRLYDYEITDQ-YIYMVME-CGNIDLNSWLKKKKS--IDPWERKSYWKNMLEAVHTIHQ 261 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-----QDTGKLPVKWTAPEALREKK 362 + VH DL N L+ D + K+ DFG+ + +D+ V + PEA+++ Sbjct: 262 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 320 Query: 363 FSTK-----------SDVWSFGILLWEIYSFGRVPYPRI--PLKDVVPRVEKGYKMDAPD 409 S + SDVWS G +L+ + ++G+ P+ +I + + ++ ++++ PD Sbjct: 321 SSRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPD 379 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQ-LEHIRTHELH 449 + DV+K C D R + +L I+TH ++ Sbjct: 380 IPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVN 420 >5IKW-A nrPDB Length = 310 Score = 185 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 115/275 (41%), Gaps = 33/275 (12%) Query: 188 WALNMKELKLLQTIGKGEFGDVMLGD-YRGNKVAVKC--IKNDATAQAFLAEASVMTQLR 244 +A+ ++ L +++ +G F V L + G + A+K + N E ++M +L Sbjct: 9 FAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELS 68 Query: 245 -HSNLVQLLGVIVEE-KGGLY---IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 H N+V L V ++ I+ EY G +V+ + + ++ +L+ D C Sbjct: 69 GHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTC 128 Query: 300 EAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLT--KEASSTQD---------TG 346 EA+ L +HRDL N+L+++ + DFG K + +D Sbjct: 129 EAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKK 188 Query: 347 KLPVKWTAPEALR---EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY 403 + + APE + K +TK+D+W+ G LL+++ + +P + + G Sbjct: 189 YTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLC------FFTLPFGESQVAICDGN 242 Query: 404 KMDAPDG--CPPAVYDVMKNCWHLDAATRPTFLQL 436 PD ++ +++ D RP Q+ Sbjct: 243 -FTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV 276 >4E7W-A nrPDB Length = 394 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 54/294 (18%), Positives = 107/294 (36%), Gaps = 44/294 (14%) Query: 195 LKLLQTIGKGEFGDVMLGDYRG-NKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLG 253 + IG G FG V ++VA+K + D + E +M ++H N+V L Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDEVAIKKVLQDKRFKN--RELQIMRIVKHPNVVDLKA 99 Query: 254 VIV-----EEKGGLYIVTEYMAKGSLV-DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +++ L +V EY+ + ++ + + + + + ++ Y+ Sbjct: 100 FFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHS 159 Query: 308 NNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE-KKF 363 HRD+ +N+L+ V K+ DFG K + + + APE + + Sbjct: 160 IGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGATNY 219 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK------------------GYKM 405 +T D+WS G ++ E+ G+ +P D + + K +K Sbjct: 220 TTNIDIWSTGCVMAELM-QGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKF 278 Query: 406 DA----------PDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ--LEHIRTHE 447 PP D++ + R T ++ + +RT E Sbjct: 279 PQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRTGE 332 >6CKI-A nrPDB Length = 316 Score = 185 bits (470), Expect = 4e-47, Method: Composition-based stats. Identities = 62/306 (20%), Positives = 105/306 (34%), Gaps = 51/306 (16%) Query: 175 GTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKND--ATA 230 G+ + + + L +G+G V + AVK I+ Sbjct: 1 GSTDSFSGRFEDVYQLQ------EDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIR 54 Query: 231 QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDC 290 E ++ Q + V L EE+ Y+V E M GS++ ++ R Sbjct: 55 SRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH--FNELE 112 Query: 291 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV---AKVSDFGLTKEASSTQD--- 344 DV A+++L HRDL N+L N K+ DFGL D Sbjct: 113 ASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSP 172 Query: 345 -------TGKLPVKWTAPEALREKK-----FSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392 T ++ APE + + + D+WS G++L+ + S G P+ Sbjct: 173 ISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLS-GYPPFVGRCG 231 Query: 393 KD---------------VVPRVEKGYKMDAPD----GCPPAVYDVMKNCWHLDAATRPTF 433 D + +++G K + PD A D++ DA R + Sbjct: 232 SDCGWDRGEACPACQNMLFESIQEG-KYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSA 290 Query: 434 LQLREQ 439 Q+ + Sbjct: 291 AQVLQH 296 >5KKR-C nrPDB Length = 395 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 111/299 (37%), Gaps = 54/299 (18%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI---KNDATAQAFLAEASVMTQL 243 L + + + +G G G V ++ G +A K I A + E V+ + Sbjct: 64 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 123 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +V G + G + I E+M GSL L+ GR + L K S+ V + + Sbjct: 124 NSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLT 180 Query: 304 YL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-DTGKLPVKWTAPEALREK 361 YL E + +HRD+ N+LV+ K+ DFG++ + + ++ + +PE L+ Sbjct: 181 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT 240 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV-------------------------V 396 +S +SD+WS G+ L E+ + GR P P K++ + Sbjct: 241 HYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 299 Query: 397 PRVEKGYKMDA-------------PDGCPP-----AVYDVMKNCWHLDAATRPTFLQLR 437 + P P D + C + A R QL Sbjct: 300 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLM 358 >3GC0-A nrPDB Length = 329 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 53/293 (18%), Positives = 106/293 (36%), Gaps = 49/293 (16%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ----AFLAEASVMTQLR 244 ++ + + +G+G +G+V VA+K I+ + + + E S++ +L+ Sbjct: 32 SIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQ 91 Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 H N+++L VI L+++ EY L Y+ + + F + + + Sbjct: 92 HRNIIELKSVIHHNH-RLHLIFEYAEN-DLKKYMDKNPD--VSMRVIKSFLYQLINGVNF 147 Query: 305 LEGNNFVHRDLAARNVLV-----SEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPE 356 +HRDL +N+L+ SE V K+ DFGL + + + + PE Sbjct: 148 CHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPE 207 Query: 357 ALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-------------- 401 L + +ST D+WS + E+ +P D + ++ + Sbjct: 208 ILLGSRHYSTSVDIWSIACIWAEML-MKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVT 266 Query: 402 ---GYKMDAPDGCPPAVYDVM------------KNCWHLDAATRPTFLQLREQ 439 +K P + V+ +D R + E Sbjct: 267 ALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEH 319 >3EQC-A nrPDB Length = 360 Score = 183 bits (466), Expect = 9e-47, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 112/299 (37%), Gaps = 54/299 (18%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI---KNDATAQAFLAEASVMTQL 243 L + + + +G G G V ++ G +A K I A + E V+ + Sbjct: 29 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 88 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +V G + G + I E+M GSL L+ GR + L K S+ V + + Sbjct: 89 NSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLT 145 Query: 304 YL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-DTGKLPVKWTAPEALREK 361 YL E + +HRD+ N+LV+ K+ DFG++ + + ++ + +PE L+ Sbjct: 146 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGT 205 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV-------------------------V 396 +S +SD+WS G+ L E+ + GR P P K++ + Sbjct: 206 HYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 264 Query: 397 PRVEKGYKMDA-------------PDGCPP-----AVYDVMKNCWHLDAATRPTFLQLR 437 + + P P D + C + A R QL Sbjct: 265 NKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM 323 >3UIM-A nrPDB Length = 326 Score = 183 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 74/290 (25%), Positives = 119/290 (41%), Gaps = 33/290 (11%) Query: 183 FYRSGWALNMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQ---AFLAEAS 238 F + +G+G FG V G G VAVK +K + T F E Sbjct: 20 FSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVE 79 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRG--RSVLGGDCLLKFSL 296 +++ H NL++L G + L +V YMA GS+ LR R + L + +L Sbjct: 80 MISMAVHRNLLRLRGFCMTPTERL-LVYPYMANGSVASCLRERPESQPPLDWPKRQRIAL 138 Query: 297 DVCEAMEYLEGN---NFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLP 349 + YL + +HRD+ A N+L+ E+ A V DFGL K + + + Sbjct: 139 GSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGT 198 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPY--------PRIPLKDVVPRVEK 401 + APE L K S K+DV+ +G++L E+ + G+ + + L D V + K Sbjct: 199 IGHIAPEYLSTGKSSEKTDVFGYGVMLLELIT-GQRAFDLARLANDDDVMLLDWVKGLLK 257 Query: 402 GYKMDAPDGC-------PPAVYDVMK---NCWHLDAATRPTFLQLREQLE 441 K++A V +++ C RP ++ LE Sbjct: 258 EKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRMLE 307 >5ZTN-A nrPDB Length = 429 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 47/224 (20%), Positives = 91/224 (40%), Gaps = 12/224 (5%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIKNDATAQA-FLAEASVMTQLRHSNLVQ 250 ++L+ IGKG FG V+ VA+K ++N+ E ++ LR + Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 157 Query: 251 LLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 + VI + + + E ++ +L + ++ + KF+ + + ++ L Sbjct: 158 TMNVIHMLENFTFRNHICMTFELLS-MNLYELIKKNKFQGFSLPLVRKFAHSILQCLDAL 216 Query: 306 EGNNFVHRDLAARNVLVSEDNV--AKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 N +H DL N+L+ + KV DFG + T + APE + ++ Sbjct: 217 HKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARY 276 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA 407 D+WS G +L E+ + G P D + + + M + Sbjct: 277 GMPIDMWSLGCILAELLT-GYPLLPGEDEGDQLACMIELLGMPS 319 >5AR8-A nrPDB Length = 326 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 126/288 (43%), Gaps = 30/288 (10%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCI-----KNDATAQAFLAEASVMT 241 + +L L+ + +G G V + +VAVK + D+ + L EA ++ Sbjct: 28 TIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILH 87 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCE 300 + R S ++ +LG+ E L IVTEYM GSL + L + + + ++ Sbjct: 88 KARFSYILPILGIC-NEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIAL 146 Query: 301 AMEYLEGN--NFVHRDLAARNVLVSEDNVAKVSDFGLTK--------EASSTQDTGKLPV 350 + YL +H DL +N+L+ + K++DFGL+K SS + Sbjct: 147 GVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTI 206 Query: 351 KWTAPEAL---REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM-- 405 + PE ++ + S K D++S+ ++ WE+ S + ++ V +G++ Sbjct: 207 IYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVI 266 Query: 406 ---DAPDGCP--PAVYDVMKNCWHLDAATRPTFLQLREQLEH-IRTHE 447 P P + ++++ W + RP+FL+ +LE +RT E Sbjct: 267 NEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFE 314 >5XD6-A nrPDB Length = 305 Score = 182 bits (463), Expect = 3e-46, Method: Composition-based stats. Identities = 77/278 (27%), Positives = 123/278 (44%), Gaps = 35/278 (12%) Query: 201 IGKGEFGDVMLGDYR-GNKVAVKCI-KNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE 258 IG+G +G V G + G A+K + + Q FLA+ S++++LR N+V LLG V+ Sbjct: 30 IGEGSYGRVFYGILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVALLGYCVDG 89 Query: 259 KGGLYIVTEYMAKGSLVDYLRSRGR-------SVLGGDCLLKFSLDVCEAMEYLEGN--- 308 + + EY GSL D L R VL +K ++ +EYL Sbjct: 90 PLRV-LAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKANP 148 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-----TQDTGKLPVKWTAPEALREKKF 363 + +HRD+ + NVL+ +D+VAK++DF L+ +A + APE Sbjct: 149 HVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGTL 208 Query: 364 STKSDVWSFGILLWEIYSFGRVP----------------YPRIPLKDVVPRVEKGYKMDA 407 STKSDV+SFG++L E+ + GR P P++ V V+ + Sbjct: 209 STKSDVYSFGVVLLELLT-GRKPVDHTLPRGQQSVVTWATPKLSEDKVKQCVDARLNGEY 267 Query: 408 PDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 P + V C +A RP + + L+ + Sbjct: 268 PPKAVAKLAAVAALCVQYEADFRPNMSIVVKALQPLLN 305 >6BFN-A nrPDB Length = 342 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 65/307 (21%), Positives = 113/307 (36%), Gaps = 63/307 (20%) Query: 200 TIGKGEFGDVMLGDYRGNKVAVKCIKNDAT------AQAFLAEASVMTQLRHSNLVQLLG 253 IG+G FG V R AVK +K +A Q+FL E +++ RH N+V G Sbjct: 29 KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAG 88 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVCEAMEYLE--GNN 309 + G +V ++ GSL D L + + L L L A+++L + Sbjct: 89 YCAQN-GFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPS 147 Query: 310 FVHRDLAARNVLVSEDNVAKVSDFGLTK------------EASSTQDTGKLPVKWTAPEA 357 +H D+ + NVL+ E K+ DFGL + + T + + + E Sbjct: 148 LIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 207 Query: 358 LREKKFSTKSDVWSFGILLWEIY------------------------------------S 381 ++ + + +D +SFG+++ E + Sbjct: 208 IKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQST 267 Query: 382 FGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA----VYDVMKNCWHLDAATRPTFLQLR 437 + ++ K + P CPP + + C H A RP Q+ Sbjct: 268 LQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVY 327 Query: 438 EQLEHIR 444 E+LE ++ Sbjct: 328 ERLEKLQ 334 >3HMP-A nrPDB Length = 342 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 124/281 (44%), Gaps = 32/281 (11%) Query: 195 LKLLQTIGKGEFGDVMLG-DYRGNKVAVKCIKNDATAQAFL----AEASVMTQLR-HSN- 247 +L+ IG G V + + A+K + + L E + + +L+ HS+ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 117 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +++L + ++ +Y+V E L +L+ + + + ++ EA+ + Sbjct: 118 IIRLYDYEITDQ-YIYMVME-CGNIDLNSWLKKKKS--IDPWERKSYWKNMLEAVHTIHQ 173 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-----QDTGKLPVKWTAPEALREKK 362 + VH DL N L+ D + K+ DFG+ + +D+ V + PEA+++ Sbjct: 174 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 232 Query: 363 FSTK-----------SDVWSFGILLWEIYSFGRVPYPRI--PLKDVVPRVEKGYKMDAPD 409 S + SDVWS G +L+ + ++G+ P+ +I + + ++ ++++ PD Sbjct: 233 SSRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPD 291 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQ-LEHIRTHELH 449 + DV+K C D R + +L I+TH ++ Sbjct: 292 IPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVN 332 >5O0Y-A nrPDB Length = 579 Score = 181 bits (461), Expect = 4e-46, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 94/278 (33%), Gaps = 41/278 (14%) Query: 206 FGDVMLGDYRGNK--VAVKC---------IKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 F +V + VAVK K + + E + +L H +V+L Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN--FVH 312 + V EY L YL+ ++ + + A++YL +H Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHK--LMSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 313 RDLAARNVLVSED---NVAKVSDFGLTKEASST----------QDTGKLPVKWTAPEAL- 358 DL N+L+ K++DFGL+K G + PE Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 359 ---REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR---VEKGYKMDAPDG-- 410 K S K DVWS G++ ++ +GR P+ + + + + K ++ P Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCL-YGRKPFGHNQSQQDILQENTILKATEVQFPPKPV 533 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLRE---QLEHIRT 445 P ++ C R QL L HIR Sbjct: 534 VTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK 571 >5TUR-A nrPDB Length = 404 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 102/262 (38%), Gaps = 25/262 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ--------AFLAEASVMTQ 242 + ++ +G G FG V G + VA+K ++ D + E ++ + Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 243 LRH--SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + S +++LL + I+ L D++ RG L + F V E Sbjct: 187 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLE 244 Query: 301 AMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKWTAPEAL 358 A+ + +HRD+ N+L+ K+ DFG T T ++ PE + Sbjct: 245 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 304 Query: 359 REKKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 R ++ + VWS GILL+++ G +P+ + +G Sbjct: 305 RYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD------EEIIRGQVF-FRQRVSSECQH 356 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 +++ C L + RPTF +++ Sbjct: 357 LIRWCLALRPSDRPTFEEIQNH 378 >5X8I-B nrPDB Length = 346 Score = 181 bits (460), Expect = 6e-46, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 117/321 (36%), Gaps = 78/321 (24%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR---GNKVAVKCIKN-DATAQAFLAEASVMTQLR--HSN 247 +++ T+G+G FG V+ G VAVK +KN D +A +E V+ L N Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPN 73 Query: 248 ----LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 VQ+L E G + IV E + S D+++ G D + K + +C+++ Sbjct: 74 STFRCVQMLEWF-EHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKSVN 131 Query: 304 YLEGNNFVHRDLAARNVLVSE-------------------DNVAKVSDFGLTKEASSTQD 344 +L N H DL N+L + + KV DFG Sbjct: 132 FLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHS 191 Query: 345 TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY- 403 T + APE + +S DVWS G +L E Y G +P K+ + +E+ Sbjct: 192 TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY-LGFTVFPTHDSKEHLAMMERILG 250 Query: 404 -------------------KMDAPDGCP-----------------------PAVYDVMKN 421 ++D + ++D+++ Sbjct: 251 PLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQK 310 Query: 422 CWHLDAATRPTFLQLREQLEH 442 D A R T LRE L+H Sbjct: 311 MLEYDPAKRIT---LREALKH 328 >5AP3-A nrPDB Length = 313 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 129/297 (43%), Gaps = 32/297 (10%) Query: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG-DYRGNKVAVKCIKNDATAQAFL--- 234 + Y ++ + +L+ IG G V + + A+K + + L Sbjct: 14 GTENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSY 73 Query: 235 -AEASVMTQLR-HSN-LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCL 291 E + + +L+ HS+ +++L + ++ +Y+V E L +L+ + + Sbjct: 74 RNEIAYLNKLQQHSDKIIRLYDYEITDQ-YIYMVME-CGNIDLNGWLKKKKS--IDPWER 129 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-----QDTG 346 + ++ EA+ + + VH DL N L+ D + K+ DFG+ + +D+ Sbjct: 130 KSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ 188 Query: 347 KLPVKWTAPEALREKKFSTK-----------SDVWSFGILLWEIYSFGRVPYPRI--PLK 393 V + PEA+++ S + SDVWS G +L+ + ++G+ P+ +I + Sbjct: 189 VGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQIS 247 Query: 394 DVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ-LEHIRTHELH 449 + ++ ++++ PD + DV+K C D R + +L I+TH ++ Sbjct: 248 KLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVN 304 >3QA8-A nrPDB Length = 676 Score = 181 bits (459), Expect = 7e-46, Method: Composition-based stats. Identities = 54/223 (24%), Positives = 91/223 (40%), Gaps = 16/223 (7%) Query: 195 LKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKND---ATAQAFLAEASVMTQLRHSNLV 249 ++ + +G G FG V + G +VA+K + + + + E +M +L H N+V Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 250 QLLGV-----IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAME 303 V + + EY G L YL L + D+ A+ Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALR 135 Query: 304 YLEGNNFVHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEAL 358 YL N +HRDL N+++ + + K+ D G KE + +++ APE L Sbjct: 136 YLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELL 195 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 401 +KK++ D WSFG L +E + R P +V + Sbjct: 196 EQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVRE 238 >3BGP-A nrPDB Length = 333 Score = 180 bits (458), Expect = 8e-46, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 102/262 (38%), Gaps = 25/262 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ--------AFLAEASVMTQ 242 + ++ +G G FG V G + VA+K ++ D + E ++ + Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 243 LRH--SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + S +++LL + I+ L D++ RG L + F V E Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLE 173 Query: 301 AMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKWTAPEAL 358 A+ + +HRD+ N+L+ K+ DFG T T ++ PE + Sbjct: 174 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 233 Query: 359 REKKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 R ++ + VWS GILL+++ G +P+ + +G Sbjct: 234 RYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD------EEIIRGQVF-FRQRVSSECQH 285 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 +++ C L + RPTF +++ Sbjct: 286 LIRWCLALRPSDRPTFEEIQNH 307 >1S9I-A nrPDB Length = 354 Score = 180 bits (458), Expect = 9e-46, Method: Composition-based stats. Identities = 68/305 (22%), Positives = 113/305 (37%), Gaps = 58/305 (19%) Query: 189 ALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCI---KNDATAQAFLAEASVMTQL 243 L + + + +G G G V +R G +A K I A + E V+ + Sbjct: 12 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC 71 Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +V G + G + I E+M GSL L+ R + + L K S+ V + Sbjct: 72 NSPYIVGFYGAFYSD-GEISICMEHMDGGSLDQVLKEAKR--IPEEILGKVSIAVLRGLA 128 Query: 304 YL-EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ-DTGKLPVKWTAPEALREK 361 YL E + +HRD+ N+LV+ K+ DFG++ + + ++ + APE L+ Sbjct: 129 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGT 188 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-------------------- 401 +S +SD+WS G+ L E+ + GR P P K++ + Sbjct: 189 HYSVQSDIWSMGLSLVEL-AVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPP 247 Query: 402 -----GYKMD-----------------APDGCP-----PAVYDVMKNCWHLDAATRPTFL 434 G+ MD P P P + + C + A R Sbjct: 248 GRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLK 307 Query: 435 QLREQ 439 L Sbjct: 308 MLTNH 312 >4KIK-B nrPDB Length = 677 Score = 180 bits (458), Expect = 9e-46, Method: Composition-based stats. Identities = 54/229 (23%), Positives = 94/229 (41%), Gaps = 16/229 (6%) Query: 195 LKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKND---ATAQAFLAEASVMTQLRHSNLV 249 ++ + +G G FG+V G ++A+K + + + + E +M +L H N+V Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 250 QLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAME 303 V + + EY G L YL L +L D+ A+ Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 304 YLEGNNFVHRDLAARNVLVSEDNV---AKVSDFGLTKEASSTQ--DTGKLPVKWTAPEAL 358 YL N +HRDL N+++ + K+ D G KE + +++ APE L Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL 200 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA 407 ++K++ D WSFG L +E + R P +V + ++D Sbjct: 201 EQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDI 249 >2ZMD-A nrPDB Length = 390 Score = 180 bits (458), Expect = 9e-46, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 124/281 (44%), Gaps = 32/281 (11%) Query: 195 LKLLQTIGKGEFGDVMLG-DYRGNKVAVKCIKNDATAQAFL----AEASVMTQLR-HSN- 247 +L+ IG G V + + A+K + + L E + + +L+ HS+ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 117 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 +++L + ++ +Y+V E L +L+ + + + ++ EA+ + Sbjct: 118 IIRLYDYEITDQ-YIYMVME-CGNIDLNSWLKKKKS--IDPWERKSYWKNMLEAVHTIHQ 173 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-----QDTGKLPVKWTAPEALREKK 362 + VH DL N L+ D + K+ DFG+ + +D+ V + PEA+++ Sbjct: 174 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMS 232 Query: 363 FSTK-----------SDVWSFGILLWEIYSFGRVPYPRI--PLKDVVPRVEKGYKMDAPD 409 S + SDVWS G +L+ + ++G+ P+ +I + + ++ ++++ PD Sbjct: 233 SSRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPD 291 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQ-LEHIRTHELH 449 + DV+K C D R + +L I+TH ++ Sbjct: 292 IPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVN 332 >2QKW-B nrPDB Length = 321 Score = 180 bits (458), Expect = 1e-45, Method: Composition-based stats. Identities = 68/267 (25%), Positives = 122/267 (45%), Gaps = 28/267 (10%) Query: 201 IGKGEFGDVMLGDYR-GNKVAVKCIKNDATAQ---AFLAEASVMTQLRHSNLVQLLGVIV 256 IG G FG V G R G KVA+K + ++Q F E ++ RH +LV L+G Sbjct: 47 IGHGVFGKVYKGVLRDGAKVALKR-RTPESSQGIEEFETEIETLSFCRHPHLVSLIGFC- 104 Query: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLG--GDCLLKFSLDVCEAMEYLEGNNFVHRD 314 +E+ + ++ +YM G+L +L + + L+ + + YL +HRD Sbjct: 105 DERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRD 164 Query: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTG-----KLPVKWTAPEALREKKFSTKSDV 369 + + N+L+ E+ V K++DFG++K+ + T K + + PE + + + KSDV Sbjct: 165 VKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDV 224 Query: 370 WSFGILLWEIYSFG-----RVPYPRIPLKDVV------PRVEKGYKMDAPDGCPPA---- 414 +SFG++L+E+ +P + L + ++E+ + D P Sbjct: 225 YSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKIRPESLRK 284 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQLE 441 D C L + RP+ + +LE Sbjct: 285 FGDTAVKCLALSSEDRPSMGDVLWKLE 311 >3DLS-A nrPDB Length = 335 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 56/286 (19%), Positives = 110/286 (38%), Gaps = 35/286 (12%) Query: 168 IKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIK 225 K +EG A + E+ + + +G G FG V + +V VK IK Sbjct: 7 PKAVELEGLAACEGEYSQK--------YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIK 58 Query: 226 NDATAQA----------FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKG-SL 274 + + E ++++++ H+N++++L + E +G +V E G L Sbjct: 59 KEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIF-ENQGFFQLVMEKHGSGLDL 117 Query: 275 VDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG 334 ++ R L + A+ YL + +HRD+ N++++ED K+ DFG Sbjct: 118 FAFIDRHPR--LDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFG 175 Query: 335 LTKEASSTQ--DTGKLPVKWTAPEALREKKF-STKSDVWSFGILLWEIYSFGRVPYPRIP 391 + T +++ APE L + + ++WS G+ L+ + + P Sbjct: 176 SAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLV------FEENP 229 Query: 392 LKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLR 437 ++ VE P + ++ R T +L Sbjct: 230 FCELEETVEAAIHP--PYLVSKELMSLVSGLLQPVPERRTTLEKLV 273 >4M66-A nrPDB Length = 325 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 74/283 (26%), Positives = 120/283 (42%), Gaps = 33/283 (11%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSN 247 ++ +ELK L+ +GKG FG V +R + VAVK + + + E M LR+ N Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW----EVKAMVNLRNEN 72 Query: 248 LVQLLGVIVEEKGGLY----IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 ++ LLGV + + +VT +M GSL L + + L + +V M Sbjct: 73 VLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLL--QPEAPRPWPLLCRLLQEVVLGMC 130 Query: 304 YLEGN--NFVHRDLAARNVLVSEDNVAKVSDFGLTK---------EASSTQDTGKLPVKW 352 YL +HRDL N+L+ + AK++DFGL+ + S + + Sbjct: 131 YLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAY 190 Query: 353 TAPEALR--EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL---KDVVPRVEKGYKMDA 407 PE L K S SDV+SFGIL+W + + + V R + + Sbjct: 191 LDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTEL 250 Query: 408 PDGCP-----PAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 P G P + ++M +CW + RP+F + + Sbjct: 251 PPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYN 293 >4RC3-A nrPDB Length = 289 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 102/262 (38%), Gaps = 25/262 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ--------AFLAEASVMTQ 242 + ++ +G G FG V G + VA+K ++ D + E ++ + Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 243 LRH--SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 + S +++LL + I+ L D++ RG L + F V E Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLE 129 Query: 301 AMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKWTAPEAL 358 A+ + +HRD+ N+L+ K+ DFG T T ++ PE + Sbjct: 130 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 189 Query: 359 REKKF-STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 R ++ + VWS GILL+++ G +P+ + +G Sbjct: 190 RYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD------EEIIRGQVF-FRQRVSSECQH 241 Query: 418 VMKNCWHLDAATRPTFLQLREQ 439 +++ C L + RPTF +++ Sbjct: 242 LIRWCLALRPSDRPTFEEIQNH 263 >4X7Q-B nrPDB Length = 312 Score = 178 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 110/261 (42%), Gaps = 27/261 (10%) Query: 194 ELKLLQTIGKGEFGDVMLGDYRGN--KVAVKCIKNDATAQA--------FLAEASVMTQL 243 E +L +GKG FG V G + +VA+K I + E +++ ++ Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 244 R----HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 H +++LL ++G + ++ + L DY+ +G LG F V Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKG--PLGEGPSRCFFGQVV 149 Query: 300 EAMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKWTAPEA 357 A+++ VHRD+ N+L+ AK+ DFG T ++ PE Sbjct: 150 AAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEW 209 Query: 358 LREKKFST-KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY 416 + ++ + VWS GILL+++ G +P+ R ++++ ++ P P Sbjct: 210 ISRHQYHALPATVWSLGILLYDMVC-GDIPFERD--QEILEA-----ELHFPAHVSPDCC 261 Query: 417 DVMKNCWHLDAATRPTFLQLR 437 +++ C ++RP+ ++ Sbjct: 262 ALIRRCLAPKPSSRPSLEEIL 282 >5TQX-A nrPDB Length = 655 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 54/274 (19%), Positives = 108/274 (39%), Gaps = 39/274 (14%) Query: 195 LKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKND---ATAQAFLAEASVMTQLRHSNLV 249 ++ + +G G FG+V L +R K+A+K + + + + E +M +L H+N+V Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 69 Query: 250 QLLGVIVEEKGGLY----IVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEY 304 + V E ++ + EY + G L L L +L D+ + Y Sbjct: 70 KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY 129 Query: 305 LEGNNFVHRDLAARNVLVSEDN---VAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALR 359 L N +HRDL N+++ + + K+ D G K+ + +++ APE Sbjct: 130 LHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELFE 189 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPY-PRIPLKDVVPRVEKG--------------YK 404 K ++ D WSFG +++E + G P+ + +++K + Sbjct: 190 NKPYTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVR 248 Query: 405 MDAPDGCPPAVYDVMKN--------CWHLDAATR 430 + P ++ ++ + D R Sbjct: 249 FSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQR 282 >3PG1-A nrPDB Length = 362 Score = 178 bits (452), Expect = 5e-45, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 111/306 (36%), Gaps = 57/306 (18%) Query: 195 LKLLQTIGKGEFGDVMLGDYR-GNKVAVKCIKNDATA-------------QAFLAEASVM 240 + + I G +G V G G VA+K + N + + L E ++ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLL 83 Query: 241 TQLRHSNLVQLLGVI--VEEK--GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296 H N++ L + EE LY+VTE M + L + + R V+ + F Sbjct: 84 NHFHHPNILGLRDIFVHFEEPAMHKLYLVTELM-RTDLAQVIHDQ-RIVISPQHIQYFMY 141 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS-STQDTGKLPVKW-TA 354 + + L VHRDL N+L++++N + DF L +E + T + +W A Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRA 201 Query: 355 PE-ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV---------PRVEKGYK 404 PE ++ K F+ D+WS G ++ E+++ + + + + P++E Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFN-RKALFRGSTFYNQLNKIVEVVGTPKIEDVVM 260 Query: 405 MDAP----------------------DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ--L 440 +P P D++ + R + Q Sbjct: 261 FSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYF 320 Query: 441 EHIRTH 446 E + Sbjct: 321 ESLFDP 326 >5VD3-A nrPDB Length = 311 Score = 176 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 116/309 (37%), Gaps = 28/309 (9%) Query: 141 DEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQT 200 E +YF+++ QL + G ++ E + + + L Sbjct: 15 TENLYFQSMHQL----QPRRVSFRGEASETLQSPGYDPSRPESFFQ------QSFQRLSR 64 Query: 201 IGKGEFGDVMLGDYR--GNKVAVKC----IKNDATAQAFLAEASVMTQL-RHSNLVQLLG 253 +G G +G+V + G AVK + LAE ++ +H V+L Sbjct: 65 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQ 124 Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 EE G LY+ TE SL + + G S L + + D A+ +L VH Sbjct: 125 AW-EEGGILYLQTELC-GPSLQQHCEAWGAS-LPEAQVWGYLRDTLLALAHLHSQGLVHL 181 Query: 314 DLAARNVLVSEDNVAKVSDFGLTKEA--SSTQDTGKLPVKWTAPEALREKKFSTKSDVWS 371 D+ N+ + K+ DFGL E + + + ++ APE L+ + T +DV+S Sbjct: 182 DVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQG-SYGTAADVFS 240 Query: 372 FGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP-DGCPPAVYDVMKNCWHLDAATR 430 G+ + E+ +P+ + ++ +GY G + V+ D R Sbjct: 241 LGLTILEVACNMELPHGG----EGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLR 296 Query: 431 PTFLQLREQ 439 T L Sbjct: 297 ATAEALLAL 305 >2RIO-A nrPDB Length = 434 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 106/280 (37%), Gaps = 41/280 (14%) Query: 198 LQTIGKGEFGDV-MLGDYRGNKVAVKCIKNDATAQAFLAEASVM-TQLRHSNLVQLLGVI 255 + +G G G V G ++G VAVK + D L E ++ H N+++ Sbjct: 20 EKILGYGSSGTVVFQGSFQGRPVAVKRMLID-FCDIALMEIKLLTESDDHPNVIRYY-CS 77 Query: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF-----SLDVCEAMEYLEGNNF 310 LYI E +L D + S+ S ++ + + +L Sbjct: 78 ETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKI 136 Query: 311 VHRDLAARNVLVS-------------EDNVAKVSDFGLTKEASSTQDTGKL-------PV 350 +HRDL +N+LVS E+ +SDFGL K+ S Q + + Sbjct: 137 IHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTS 196 Query: 351 KWTAPEALRE-------KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD--VVPRVEK 401 W APE L E ++ + D++S G + + I S G+ P+ ++ ++ + Sbjct: 197 GWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFS 256 Query: 402 GYKMDAPDGCP--PAVYDVMKNCWHLDAATRPTFLQLREQ 439 +M D++ D RPT +++ Sbjct: 257 LDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRH 296 >3E3P-A nrPDB Length = 360 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 72/323 (22%), Positives = 120/323 (37%), Gaps = 67/323 (20%) Query: 175 GTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQA 232 AA DE R M ++ + G+G FG V LG + G VA+K + D + Sbjct: 9 NAAAAADERSRK----EMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN 64 Query: 233 FLAEASVMTQL---RHSNLVQLLGVIV----EEKGGLYI--VTEYMAKGSLVDYLRSRGR 283 E +M L H N+VQL ++ +Y+ V EY+ +L R+ R Sbjct: 65 --RELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPD-TLHRCCRNYYR 121 Query: 284 SVLGGDCLL--KFSLDVCEAMEYLE--GNNFVHRDLAARNVLVSE-DNVAKVSDFGLTKE 338 + +L F + ++ L N HRD+ NVLV+E D K+ DFG K+ Sbjct: 122 RQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKK 181 Query: 339 ASSTQDTGKL--PVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPR------ 389 S ++ + APE + + ++T D+WS G + E+ G + Sbjct: 182 LSPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMM-LGEPIFRGDNSAGQ 240 Query: 390 ---------IPLKDVVPRVEKGY---KMDAPDGCP-------------PAVYDVMKNCWH 424 P ++V+ ++ + + G P YD++ Sbjct: 241 LHEIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQ 300 Query: 425 LDAATR---------PTFLQLRE 438 R P F +L + Sbjct: 301 YLPEERMKPYEALCHPYFDELHD 323 >6FYV-A nrPDB Length = 337 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 62/320 (19%), Positives = 109/320 (34%), Gaps = 75/320 (23%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGN---KVAVKCIKN-DATAQAFLAEASVMTQLRH-- 245 +++ T+G+G FG V+ G VAVK +KN +A +E V+ L Sbjct: 13 RARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTD 72 Query: 246 SN----LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 N VQ+L + G + IV E + S D+++ D + + + +C++ Sbjct: 73 PNSVFRCVQMLEWF-DHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQS 130 Query: 302 MEYLEGNNFVHRDLAARNVLVSE-------------------DNVAKVSDFGLTKEASST 342 + +L N H DL N+L + + KV DFG Sbjct: 131 INFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH 190 Query: 343 QDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK- 401 T + APE + +S DVWS G +L E Y G + K+ + +E+ Sbjct: 191 HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYY-LGFTVFQTHDSKEHLAMMERI 249 Query: 402 -------------------GYKMDAPDGCP-----------------------PAVYDVM 419 ++D + ++D++ Sbjct: 250 LGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLV 309 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + D R T + + Sbjct: 310 RRMLEYDPTQRITLDEALQH 329 >2I6L-A nrPDB Length = 320 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 103/301 (34%), Gaps = 59/301 (19%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCI--KNDATAQAFLAEASVMTQLRHSNL 248 L+ +G G G V +VA+K I + + + L E ++ +L H N+ Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNI 70 Query: 249 VQLLGVI-------------VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 V++ ++ + E +YIV EYM L + L L + F Sbjct: 71 VKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVLEQ---GPLLEEHARLFM 126 Query: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASS------TQDTGKL 348 + ++Y+ N +HRDL N+ ++ ED V K+ DFGL + G + Sbjct: 127 YQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLV 186 Query: 349 PVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK------ 401 + +P L ++ D+W+ G + E+ + G+ + + + + + Sbjct: 187 TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLT-GKTLFAGAHELEQMQLILESIPVVH 245 Query: 402 ---------------GYKMDAP--------DGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 M P G D ++ R T + Sbjct: 246 EEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALS 305 Query: 439 Q 439 Sbjct: 306 H 306 >3N9X-A nrPDB Length = 432 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 58/352 (16%), Positives = 120/352 (34%), Gaps = 100/352 (28%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK----NDATAQAFLAEASVMTQLRHS 246 + IG+G +G V L + + VA+K + + + L E +++ +L+ Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 85 Query: 247 NLVQLLGVIVEEK----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 +++L +I+ + LYIV E +A L ++ L + + ++ Sbjct: 86 YIIRLYDLIIPDDLLKFDELYIVLE-IADSDLKKLFKT--PIFLTEEHIKTILYNLLLGE 142 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT----------------- 345 ++ + +HRDL N L+++D KV DFGL + +S +DT Sbjct: 143 NFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNK 202 Query: 346 --------GKLPVKWTAPE-ALREKKFSTKSDVWSFGILLWEIY----------SFGRVP 386 + + APE L ++ ++ D+WS G + E+ + Sbjct: 203 NLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPL 262 Query: 387 YPR-----------------------------------------IPLKDVVPRVEKGYKM 405 +P I +V+ + K + Sbjct: 263 FPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYI-KLFPH 321 Query: 406 DAP-------DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ--LEHIRTHEL 448 P +++++ + R T Q + L+ +R +L Sbjct: 322 RKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKKL 373 >4Y83-A nrPDB Length = 332 Score = 174 bits (441), Expect = 8e-44, Method: Composition-based stats. Identities = 53/250 (21%), Positives = 104/250 (41%), Gaps = 19/250 (7%) Query: 201 IGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE 258 I +G FG V L ++A K I D ++ + RH N+ +L G ++ Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKP---SDVEIQACFRHENIAELYGAVLWG 137 Query: 259 KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAAR 318 + +++ E GS+++ L S G + ++ + V + +++L +H D+ Sbjct: 138 ET-VHLFMEAGEGGSVLEKLESCG--PMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPS 194 Query: 319 NVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEALREKKFSTKSDVWSFGIL 375 N++ + DFGL+ + + K + +PE + + STK+D++S G Sbjct: 195 NIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGAT 253 Query: 376 LWEIYSFGRVP----YPRIPLKDVVPRVEKGYKM--DAPDGCPPAVYDVMKNCWHLDAAT 429 L + + G P YPR + + K D D C P + ++++ + Sbjct: 254 LIHMQT-GTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNH 312 Query: 430 RPTFLQLREQ 439 RP L + Sbjct: 313 RPRAADLLKH 322 >3M42-A nrPDB Length = 299 Score = 173 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 100/257 (38%), Gaps = 39/257 (15%) Query: 199 QTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEASVM-TQLRHSNLVQLLGVI 255 Q +G G G V + K A+K +++ A+ E + + ++V+++ V Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR---REVELHWRASQCPHIVRIVDVY 80 Query: 256 VE---EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 + L IV E + G L ++ RG + + EA++YL N H Sbjct: 81 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 140 Query: 313 RDLAARNVLVSE---DNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDV 369 RD+ N+L + + + K++DFG KE + +K+ D+ Sbjct: 141 RDVKPENLLYTSKRPNAILKLTDFGFAKETT-------------------GEKYDKSCDM 181 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVP----RVEKG-YKMDAPD--GCPPAVYDVMKNC 422 WS G++++ + G P+ + P R+ G Y+ P+ V +++N Sbjct: 182 WSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNL 240 Query: 423 WHLDAATRPTFLQLREQ 439 + R T + Sbjct: 241 LKTEPTQRMTITEFMNH 257 >4OW8-A nrPDB Length = 283 Score = 173 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 63/252 (25%), Positives = 104/252 (41%), Gaps = 18/252 (7%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQLRHS 246 +L + I G G V G +VAVK +K++ ++ + F AEA L H Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 247 NLVQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + + + G Y+V E + L L+ GR L L A+ Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 129 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDTGKL--PVKWTAPEAL 358 + VHRD+ N+L++ K++DFG+ K +A+ TG + ++ APE Sbjct: 130 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 189 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 S SDV+S G++ +E S G+ P+ V + K P PP V ++ Sbjct: 190 LGHDASPASDVYSLGVVGYEAVS-GKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVREL 248 Query: 419 MKNCWHLDAATR 430 ++ + A R Sbjct: 249 IEITLVKNPAMR 260 >4X3F-A nrPDB Length = 337 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 63/252 (25%), Positives = 104/252 (41%), Gaps = 18/252 (7%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQLRHS 246 +L + I G G V G +VAVK +K++ ++ + F AEA L H Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 247 NLVQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + + + G Y+V E + L L+ GR L L A+ Sbjct: 73 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 130 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDTGKL--PVKWTAPEAL 358 + VHRD+ N+L++ K++DFG+ K +A+ TG + ++ APE Sbjct: 131 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 190 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 S SDV+S G++ +E S G+ P+ V + K P PP V ++ Sbjct: 191 LGHDASPASDVYSLGVVGYEAVS-GKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVREL 249 Query: 419 MKNCWHLDAATR 430 ++ + A R Sbjct: 250 IEITLVKNPAMR 261 >6B2Q-A nrPDB Length = 317 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 63/252 (25%), Positives = 104/252 (41%), Gaps = 18/252 (7%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQLRHS 246 +L + I G G V G +VAVK +K++ ++ + F AEA L H Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 247 NLVQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + + + G Y+V E + L L+ GR L L A+ Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 150 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQDTGKL--PVKWTAPEAL 358 + VHRD+ N+L++ K++DFG+ K +A+ TG + ++ APE Sbjct: 151 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 210 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 S SDV+S G++ +E S G+ P+ V + K P PP V ++ Sbjct: 211 LGHDASPASDVYSLGVVGYEAVS-GKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVREL 269 Query: 419 MKNCWHLDAATR 430 ++ + A R Sbjct: 270 IEITLVKNPAMR 281 >3SOC-A nrPDB Length = 322 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 122/295 (41%), Gaps = 48/295 (16%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK-NDATAQAFLAEASVMTQLRHSNLVQLLG 253 L+LL+ +G FG V VAVK D + E + ++H N++Q +G Sbjct: 26 LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG 85 Query: 254 VIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN-- 308 L+++T + KGSL D+L++ V+ + L + + + YL + Sbjct: 86 AEKRGTSVDVDLWLITAFHEKGSLSDFLKAN---VVSWNELCHIAETMARGLAYLHEDIP 142 Query: 309 --------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-----PVKWTAP 355 HRD+ ++NVL+ + A ++DFGL + + + G ++ AP Sbjct: 143 GLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAP 202 Query: 356 EALRE-----KKFSTKSDVWSFGILLWEIYSF-----GRVPYPRIPLKDVVPR------- 398 E L + + D+++ G++LWE+ S G V +P ++ + + Sbjct: 203 EVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM 262 Query: 399 ----VEKGYKMDAPDGCPPA-----VYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 V K + D + + ++ CW DA R + + E++ ++ Sbjct: 263 QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQ 317 >2WO6-A nrPDB Length = 382 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 57/257 (22%), Positives = 105/257 (40%), Gaps = 26/257 (10%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDA-TAQAFLAEASVMTQLR-HSN 247 M ++ IGKG FG V+ R + VA+K IKN E ++ + H Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 112 Query: 248 LVQLLGVIVEE----KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 ++ V ++ + L +V E ++ +L D LR+ + + KF+ +C A+ Sbjct: 113 EMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMCTALL 171 Query: 304 YLE--GNNFVHRDLAARNVLV--SEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALR 359 +L + +H DL N+L+ + + K+ DFG + + + +PE L Sbjct: 172 FLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 231 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVM 419 + D+WS G +L E+++ G + D + ++ + G PPA Sbjct: 232 GMPYDLAIDMWSLGCILVEMHT-GEPLFSGANEVDQMNKIVEVL------GIPPA----- 279 Query: 420 KNCWHLDAATRPTFLQL 436 + R F +L Sbjct: 280 -HILDQAPKARKFFEKL 295 >1TKI-A nrPDB Length = 321 Score = 172 bits (437), Expect = 3e-43, Method: Composition-based stats. Identities = 51/257 (19%), Positives = 108/257 (42%), Gaps = 13/257 (5%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQAF-LAEASVMTQLRHSNLV 249 ++ + + +G+GEFG V +K K +K T Q E S++ RH N++ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNIL 64 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 L E L ++ E+++ + + + + L ++ + VCEA+++L +N Sbjct: 65 HLHESF-ESMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHSHN 122 Query: 310 FVHRDLAARNVLVS--EDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALREKKFST 365 H D+ N++ + K+ +FG ++ + L ++ APE + ST Sbjct: 123 IGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVST 182 Query: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG---YKMDAPDGCPPAVYDVMKNC 422 +D+WS G L++ + S G P+ + ++ + + +A D + Sbjct: 183 ATDMWSLGTLVYVLLS-GINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRL 241 Query: 423 WHLDAATRPTFLQLREQ 439 + +R T + + Sbjct: 242 LVKERKSRMTASEALQH 258 >3EB0-A nrPDB Length = 383 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 61/334 (18%), Positives = 118/334 (35%), Gaps = 79/334 (23%) Query: 187 GWALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQAFLAEASVMTQLR 244 G + K+ L +T+G G FG V G + A+K + D + E +M L Sbjct: 1 GLETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN--RELDIMKVLD 58 Query: 245 HSNLVQLLGVIVEEKG-------------------------------------GLYIVTE 267 H N+++L+ L ++ E Sbjct: 59 HVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIME 118 Query: 268 YMAKGSLVDYLRS--RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE- 324 Y+ +L L+S R + + + + + A+ ++ HRD+ +N+LV+ Sbjct: 119 YVPD-TLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSK 177 Query: 325 DNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYS 381 DN K+ DFG K+ ++ + + APE + +++ D+WS G + E+ Sbjct: 178 DNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELI- 236 Query: 382 FGRVPYPRIPLKDVVPRV---------EKGYKMDA-------------------PDGCPP 413 G+ + D + R+ E+ +M+ P+G P Sbjct: 237 LGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPS 296 Query: 414 AVYDVMKNCWHLDAATR--PTFLQLREQLEHIRT 445 D+++ + R P +H+R Sbjct: 297 LAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRN 330 >5E8V-A nrPDB Length = 316 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 112/303 (36%), Gaps = 57/303 (18%) Query: 195 LKLLQTIGKGEFGDVMLGDYRG------NKVAVKCIKNDATAQAFLAEASVMT--QLRHS 246 ++L +GKG F +V + VAVK + A ++ E + + L+H Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYA-SWKTEKDIFSDINLKHE 69 Query: 247 NLVQLL---GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 N++Q L E +++T + AKG+L +YL R V+ + L K + + Sbjct: 70 NILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL---TRHVISWEDLRKLGSSLARGIA 126 Query: 304 YLEG---------NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST-------QDTGK 347 +L VHRDL + N+LV D + DFGL+ T Sbjct: 127 HLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQV 186 Query: 348 LPVKWTAPEA------LREKKFSTKSDVWSFGILLWEIYSFG---------RVPY----- 387 ++ APE L + ++DV+S ++LWE+ S P+ Sbjct: 187 GTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVR 246 Query: 388 PRIPLKDVVPRV-EKGYKMDAPDGCP-----PAVYDVMKNCWHLDAATRPTFLQLREQLE 441 + + V + + P V + + CW D R T + E+ Sbjct: 247 EHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFS 306 Query: 442 HIR 444 + Sbjct: 307 ELE 309 >3G2F-A nrPDB Length = 336 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 67/315 (21%), Positives = 116/315 (36%), Gaps = 61/315 (19%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMT--QL 243 S +L++ LKLL+ IG+G +G V G VAVK A Q F+ E ++ + Sbjct: 6 SEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFS-FANRQNFINEKNIYRVPLM 64 Query: 244 RHSNLVQLL----GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 H N+ + + V + + +V EY GSL YL + + V Sbjct: 65 EHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS---DWVSSCRLAHSVT 121 Query: 300 EAMEYLEGN---------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG---- 346 + YL HRDL +RNVLV D +SDFGL+ + + Sbjct: 122 RGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEE 181 Query: 347 -------KLPVKWTAPEALRE-------KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392 +++ APE L + + D+++ G++ WEI+ +P + Sbjct: 182 DNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESV 241 Query: 393 KDVVPRVEKGY--------------KMDAPDGCPP----------AVYDVMKNCWHLDAA 428 + + + P ++ + +++CW DA Sbjct: 242 PEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAE 301 Query: 429 TRPTFLQLREQLEHI 443 R T E++ + Sbjct: 302 ARLTAQCAEERMAEL 316 >4L00-A nrPDB Length = 304 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 70/277 (25%), Positives = 116/277 (41%), Gaps = 27/277 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--------RGNKVAVKCIKN------DATAQAFLAEAS 238 K+L + +G+G + G + +K I + AF AS Sbjct: 25 KDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAAS 84 Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 +M Q+ H ++V L GV V + + +V E++ G L D R VL K + + Sbjct: 85 MMRQVSHKHIVYLYGVCVRDVENI-MVEEFVEGGPL-DLFMHRKSDVLTTPWKFKVAKQL 142 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNV-------AKVSDFGLTKEASSTQDTGKLPVK 351 A+ YLE + VH ++ +N+L++ + + K+SD G+ S Q+ + + Sbjct: 143 ASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIE-RIP 201 Query: 352 WTAPEALREKK-FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG 410 W APE + + K S +D WSFG LWEI G +P L + E + P Sbjct: 202 WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS- 260 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 C + D+M C + D RP F + + + Sbjct: 261 C-KELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQN 296 >4IDT-A nrPDB Length = 356 Score = 168 bits (426), Expect = 5e-42, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 110/306 (35%), Gaps = 25/306 (8%) Query: 147 ENLMQLVEHYTTDADGLCTRLIKPKVMEG---TVAAQDEFYRSGWALNMKELKLLQTIGK 203 +L L + + K + EG T + Y ++ +L +G+ Sbjct: 27 HSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQL--RLGR 84 Query: 204 GEFGDVML--GDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGG 261 G FG+V G + AVK ++ + E L +V L G + E Sbjct: 85 GSFGEVHRMEDKQTGFQCAVKKVRLEVFR---AEELMACAGLTSPRIVPLYGAV-REGPW 140 Query: 262 LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVL 321 + I E + GSL ++ +G L D L + E +EYL +H D+ A NVL Sbjct: 141 VNIFMELLEGGSLGQLVKEQG--CLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVL 198 Query: 322 VSEDN-VAKVSDFGLT-KEASSTQDTGKLPVKW-------TAPEALREKKFSTKSDVWSF 372 +S D A + DFG L + APE + + K DVWS Sbjct: 199 LSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSS 258 Query: 373 GILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM--DAPDGCPPAVYDVMKNCWHLDAATR 430 ++ + + G P+ + + ++ + P C P ++ + R Sbjct: 259 CCMMLHMLN-GCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHR 317 Query: 431 PTFLQL 436 + +L Sbjct: 318 VSAAEL 323 >3RP9-A nrPDB Length = 458 Score = 167 bits (424), Expect = 8e-42, Method: Composition-based stats. Identities = 63/385 (16%), Positives = 120/385 (31%), Gaps = 106/385 (27%) Query: 157 TTDADGLCTRLIKPKVMEGTVAAQD-EFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR 215 G + K + S W + ++ IG G +G V + Sbjct: 17 QHTVSGSQQEGQQRKQHHSSKPTASMPRPHSDWQIP-DRYEIRHLIGTGSYGHVCEAYDK 75 Query: 216 GNK--VAVKCI----KNDATAQAFLAEASVMTQLRHSNLVQLLGVI----VEEKGGLYIV 265 K VA+K I ++ + L E +++ +L H ++V++L ++ VE+ LY+V Sbjct: 76 LEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVV 135 Query: 266 TEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSED 325 E +A R+ L + ++ ++Y+ +HRDL N LV++D Sbjct: 136 LE-IADSDFKKLFRT--PVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQD 192 Query: 326 NVAKVSDFGLTKEASSTQD------------------------------TGKLPVKWTAP 355 KV DFGL + ++ + + AP Sbjct: 193 CSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAP 252 Query: 356 E-ALREKKFSTKSDVWSFGILLWEIYSF----------------GRVPYP---------- 388 E L ++ ++ DVWS G + E+ + G +P Sbjct: 253 ELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGND 312 Query: 389 -------------------RIPLKDVVPRVEK--------------GYKM-DAPDGCPPA 414 P ++ + +EK G + + Sbjct: 313 FKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGTDLAERFPASSAD 372 Query: 415 VYDVMKNCWHLDAATRPTFLQLREQ 439 ++K + R T + Sbjct: 373 AIHLLKRMLVFNPNKRITINECLAH 397 >1GRI-A nrPDB Length = 217 Score = 167 bits (423), Expect = 9e-42, Method: Composition-based stats. Identities = 53/149 (35%), Positives = 85/149 (57%), Gaps = 12/149 (8%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72 E IAKY+F TA+ +L F +GD+L ++ D NWYKA+ G++G IP NY++ Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAEL-NGKDGFIPKNYIE------ 54 Query: 73 AGTKLSLMPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCEGKVEHYRI 131 + PWF GKI R +AE +L G FL+RES + PGD++L V V+H+++ Sbjct: 55 ----MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV 110 Query: 132 MYHASKLSIDEEVYFENLMQLVEHYTTDA 160 + + V F +L +LV+++ + + Sbjct: 111 LRDGAGKYFLWVVKFNSLNELVDYHRSTS 139 Score = 58.0 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 18/58 (31%), Positives = 30/58 (51%), Gaps = 2/58 (3%) Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKRE 69 T A ++F + +L F +GD + ++ + DPNW+K G+ G+ P NYV Sbjct: 159 TYVQALFDFDPQEDGELGFRRGDFIHVMDNS-DPNWWKGACH-GQTGMFPRNYVTPVN 214 >6HV0-A nrPDB Length = 416 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 57/259 (22%), Positives = 107/259 (41%), Gaps = 24/259 (9%) Query: 200 TIGKGEFGD-VMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLR-HSNLVQLLGVIVE 257 +G G G V G + VAVK I + + A E ++ + H N+++ + Sbjct: 15 VLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFAD-REVQLLRESDEHPNVIRYF-CTEK 72 Query: 258 EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAA 317 ++ YI E A +L +Y+ + + LG + + + +L N VHRDL Sbjct: 73 DRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLHSLNIVHRDLKP 130 Query: 318 RNVLV---SEDNVAK--VSDFGLTKEAS------STQDTGKLPVKWTAPEALRE---KKF 363 N+L+ + K +SDFGL K+ + S + W APE L E + Sbjct: 131 HNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENP 190 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA--PDGCPPAV-YDVMK 420 + D++S G + + + S G P+ L+ + +D P+ + ++++ Sbjct: 191 TYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSLDCLHPEKHEDVIARELIE 249 Query: 421 NCWHLDAATRPTFLQLREQ 439 +D RP+ + + Sbjct: 250 KMIAMDPQKRPSAKHVLKH 268 >3NIE-A nrPDB Length = 429 Score = 166 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 58/354 (16%), Positives = 119/354 (33%), Gaps = 101/354 (28%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRG--NKVAVKCIK----NDATAQAFLAEASVMTQLRHS 246 ++ IG+G +G V L + VA+K + + + L E +++ +L+ Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 247 NLVQLLGVIVEEK----GGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 +++L +I+ E LYIV E +A L ++ L + ++ Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLE-IADSDLKKLFKT--PIFLTEQHVKTILYNLLLGE 144 Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------------------ 344 +++ + +HRDL N L+++D K+ DFGL + +S +D Sbjct: 145 KFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 345 ----------TGKLPVKWTAPE-ALREKKFSTKSDVWSFGILLWEIY----------SFG 383 + + + APE L ++ ++ D+WS G + E+ + Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNR 264 Query: 384 RVPYP--------------------------------RIPLKDVVPRVEKG------YKM 405 +P P ++ + + K Sbjct: 265 FPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLF 324 Query: 406 DAPDG---------CPPAVYDVMKNCWHLDAATRPTFLQLREQ--LEHIRTHEL 448 DG D++++ +A R T + L+ +R L Sbjct: 325 PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENL 378 >5VC6-A nrPDB Length = 289 Score = 165 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 64/276 (23%), Positives = 104/276 (37%), Gaps = 37/276 (13%) Query: 194 ELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKN----DATAQAFLAEASVMTQL-RHS 246 E L+ IG GEFG V G A+K K Q L E L +HS Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVCEAMEY 304 ++V+ E+ + I EY GSL D + R S L L V + Y Sbjct: 72 HVVRYFSAWAED-DHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 305 LEGNNFVHRDLAARNVLVSEDNVA-------------------KVSDFGLTKEASSTQDT 345 + + VH D+ N+ +S ++ K+ D G SS Q Sbjct: 131 IHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ-V 189 Query: 346 GKLPVKWTAPEALREKKFS--TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY 403 + ++ A E L+E ++ K+D+++ + + + + G P PR D + +G Sbjct: 190 EEGDSRFLANEVLQEN-YTHLPKADIFALALTV--VCAAGAEPLPR--NGDQWHEIRQGR 244 Query: 404 KMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 P +++K H D RP+ + L + Sbjct: 245 LPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKH 280 >4PL5-B nrPDB Length = 435 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 57/259 (22%), Positives = 105/259 (40%), Gaps = 24/259 (9%) Query: 200 TIGKGEFGD-VMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLR-HSNLVQLLGVIVE 257 +G G G V G + VAVK I + + A E ++ + H N+++ + Sbjct: 34 VLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFAD-REVQLLRESDEHPNVIRYF-CTEK 91 Query: 258 EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAA 317 ++ YI E A +L +Y+ + + LG + + + +L N VHRDL Sbjct: 92 DRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLHSLNIVHRDLKP 149 Query: 318 RNVLV---SEDNVAK--VSDFGLTKEAS------STQDTGKLPVKWTAPEALRE---KKF 363 N+L+ + K +SDFGL K+ + S + W APE L E Sbjct: 150 HNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNP 209 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA--PDGCPPAV-YDVMK 420 + D++S G + + + S G P+ L+ + +D D + ++++ Sbjct: 210 TYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNLDCFHSDKHEDVIARELIE 268 Query: 421 NCWHLDAATRPTFLQLREQ 439 +D RP+ + + Sbjct: 269 KMIAMDPQQRPSAKHVLKH 287 >3RAW-A nrPDB Length = 381 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 109/320 (34%), Gaps = 75/320 (23%) Query: 192 MKELKLLQTIGKGEFGDV--MLGDYRGN-KVAVKCIKN-DATAQAFLAEASVMTQLR--- 244 + +++ +G+G FG V L RG +VA+K I+N +A E +V+ +++ Sbjct: 50 QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD 109 Query: 245 --HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + L L+ G + I E + + ++L+ + + +C A+ Sbjct: 110 KENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHAL 168 Query: 303 EYLEGNNFVHRDLAARNVLVS-------------------EDNVAKVSDFGLTKEASSTQ 343 +L N H DL N+L ++ +V+DFG Sbjct: 169 RFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHH 228 Query: 344 DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY 403 T + PE + E ++ DVWS G +L+E Y G + ++ + +EK Sbjct: 229 TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYY-RGFTLFQTHENREHLVMMEKIL 287 Query: 404 KMDAP-------------------------------DGCPP-------------AVYDVM 419 P + C P ++D+M Sbjct: 288 G-PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLM 346 Query: 420 KNCWHLDAATRPTFLQLREQ 439 + D A R T + Sbjct: 347 RRMLEFDPAQRITLAEALLH 366 >2QLU-A nrPDB Length = 314 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 67/301 (22%), Positives = 121/301 (40%), Gaps = 49/301 (16%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK-NDATAQAFLAEASVMTQLRHSNL 248 + L+LL+ +G FG V + VAVK D + E ++H NL Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENL 71 Query: 249 VQLLGVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 +Q + L+++T + KGSL DYL+ ++ + L + + + YL Sbjct: 72 LQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGN---IITWNELCHVAETMSRGLSYL 128 Query: 306 EGN-----------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-----P 349 + + HRD ++NVL+ D A ++DFGL + G Sbjct: 129 HEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGT 188 Query: 350 VKWTAPEALRE-----KKFSTKSDVWSFGILLWEIYSF-----GRVPYPRIPLKDVV--- 396 ++ APE L + + D+++ G++LWE+ S G V +P ++ + Sbjct: 189 RRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQH 248 Query: 397 PRVEKGYKMDAPDGCPPAVYD-------------VMKNCWHLDAATRPTFLQLREQLEHI 443 P +E+ ++ P + D ++ CW DA R + + E++ I Sbjct: 249 PSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLI 308 Query: 444 R 444 R Sbjct: 309 R 309 >5UNP-A nrPDB Length = 369 Score = 164 bits (416), Expect = 7e-41, Method: Composition-based stats. Identities = 59/319 (18%), Positives = 115/319 (36%), Gaps = 73/319 (22%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYR---GNKVAVKCIKN-DATAQAFLAEASVMTQL---- 243 + +++ T+G+G FG V+ G +VA+K IKN + +A E +V+ ++ Sbjct: 33 QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKD 92 Query: 244 -RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 + NL + + G + I E + S D+L+ + + +C+A+ Sbjct: 93 PDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAV 151 Query: 303 EYLEGNNFVHRDLAARNVL-VSEDNV------------------AKVSDFGLTKEASSTQ 343 ++L N H DL N+L V+ D +V DFG Sbjct: 152 KFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHH 211 Query: 344 DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK-- 401 T + APE + E +S DVWS G +++E Y G + ++ + +E+ Sbjct: 212 STIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYY-VGFTLFQTHDNREHLAMMERIL 270 Query: 402 ------------------GYKMDAPDGCPP-----------------------AVYDVMK 420 ++D + ++D+++ Sbjct: 271 GPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIE 330 Query: 421 NCWHLDAATRPTFLQLREQ 439 + + A R T + + Sbjct: 331 SMLEYEPAKRLTLGEALQH 349 >5J0A-A nrPDB Length = 300 Score = 163 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 106/289 (36%), Gaps = 47/289 (16%) Query: 197 LLQTIGKGEFGD---VMLGDYRGNKV-----AVKCIK-------NDATAQAFLAEASVMT 241 +Q +G FG V L + AVK I + + EA ++ Sbjct: 13 FMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILK 69 Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR---GRSVLGGDCLLKFSLDV 298 L H N+V G L + EY + SL D + R + +LK +L++ Sbjct: 70 SLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNM 129 Query: 299 CEAMEYLE-GNNFVHRDLAARNVLVSEDN-VAKVSDFGLT------KEASSTQDTGKLPV 350 ++YL +H D+ + NV++ D K+ D G++ E + + Sbjct: 130 ARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTE 189 Query: 351 KWTAPEALREKKF-STKSDVWSFGILLWEIYSFGRVP-------------YPRIPLKDVV 396 W EA+ E + K+D+++FG+ LWE+ + + D Sbjct: 190 PWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEA 249 Query: 397 PRVEKGYK----MDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 G + M+ D V ++ C + D RP+ + E LE Sbjct: 250 YYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALE 298 >4G3E-A nrPDB Length = 352 Score = 161 bits (409), Expect = 4e-40, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 116/308 (37%), Gaps = 25/308 (8%) Query: 147 ENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQ---TIGK 203 +L L + +++ + L + + EG + + +E+ + +G+ Sbjct: 27 HSLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVDYEY--REEVHWMTHQPRVGR 84 Query: 204 GEFGDV--MLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGG 261 G FG+V M G + AVK ++ + + E L +V L G + E Sbjct: 85 GSFGEVHRMKDKQTGFQCAVKKVRLEVFR---VEELVACAGLSSPRIVPLYGAV-REGPW 140 Query: 262 LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVL 321 + I E + GSL ++ G L D L + E +EYL +H D+ A NVL Sbjct: 141 VNIFMELLEGGSLGQLIKQMG--CLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVL 198 Query: 322 VSEDNV-AKVSDFGLT-KEASSTQDTGKLPVKW-------TAPEALREKKFSTKSDVWSF 372 +S D A + DFG L + APE + K K D+WS Sbjct: 199 LSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSS 258 Query: 373 GILLWEIYSFGRVPYPRIPLKDVVPRVEK--GYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 ++ + + G P+ + + ++ + P C P ++ + R Sbjct: 259 CCMMLHMLN-GCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHR 317 Query: 431 PTFLQLRE 438 + ++LR Sbjct: 318 ASAMELRR 325 >4BTK-A nrPDB Length = 337 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 59/304 (19%), Positives = 123/304 (40%), Gaps = 19/304 (6%) Query: 155 HYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY 214 ++ ++A +K + Q + + + + K+L+ IG G FG++ Sbjct: 19 YFQSNAMQCLAAALKDETNMSGGGEQADILPANYVVK-DRWKVLKKIGGGGFGEIYEAMD 77 Query: 215 --RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKG 272 VA+K Q E +V+ +L+ + V + Y+V + Sbjct: 78 LLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQL-QGR 136 Query: 273 SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV----LVSEDNVA 328 +L D RS+ R L+ + E++E + F+HRD+ N L S Sbjct: 137 NLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKC 196 Query: 329 KVSDFGLTKEASSTQDTG---------KLPVKWTAPEALREKKFSTKSDVWSFGILLWEI 379 + DFGL ++ ++T + V++ + A + ++ D+WS +L E Sbjct: 197 YMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVE- 255 Query: 380 YSFGRVPYPRIPLKDVVPRVEKGYKMDA-PDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 ++ G++P+ +I K+ V +++ Y+ P + + + LD T+P + + Sbjct: 256 FAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMS 315 Query: 439 QLEH 442 E+ Sbjct: 316 VFEN 319 >5C01-A nrPDB Length = 342 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 67/251 (26%), Positives = 109/251 (43%), Gaps = 28/251 (11%) Query: 212 GDYRGNK--VAVKCIKNDA--TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTE 267 G RG + V +K + A AF AS+M+Q+ H++L + GV V + +VTE Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI-MVTE 159 Query: 268 YMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV 327 Y+ G L +LR R R + + + + A+ YLE N VH ++ RN+L++ + Sbjct: 160 YVEHGPLDVWLR-RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 218 Query: 328 -------AKVSDFG-----LTKEASSTQDTGKLPVKWTAPEALREK--KFSTKSDVWSFG 373 K+SD G L++E + + W APE L ST D W FG Sbjct: 219 AEGTSPFIKLSDPGVGLGALSREERVER------IPWLAPECLPGGANSLSTAMDKWGFG 272 Query: 374 ILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTF 433 L EI G P + ++ +++ P CP + + C + RP+F Sbjct: 273 ATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CPQ-LATLTSQCLTYEPTQRPSF 330 Query: 434 LQLREQLEHIR 444 + L ++ Sbjct: 331 RTILRDLTRLQ 341 >6O6Q-A nrPDB Length = 335 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 46/292 (15%), Positives = 107/292 (36%), Gaps = 49/292 (16%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQL-RHSN 247 + ++L+ +G+G++ +V LG + KV +K +K + E S++ L N Sbjct: 39 PQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKP-VKRKKIKREISILKNLVDGPN 97 Query: 248 LVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 ++ +L V+ E + ++ E++ + + ++ +A++Y Sbjct: 98 IIAMLDVVREPQSKTPGLIFEHINNIDFRSL-----YPTFTDYDIRFYMYELLKALDYSH 152 Query: 307 GNNFVHRDLAARNVLVSED-NVAKVSDFGLTKEASS-TQDTGKLPVKW-TAPEAL-REKK 362 +HRD+ NV++ D + ++ D+GL + T+ ++ ++ PE L + Sbjct: 153 SMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRL 212 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK------------------GYK 404 + D+WSFG +L + + D + ++ + G + Sbjct: 213 YDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGEE 272 Query: 405 MDAP-----------------DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 + D D++ D R T + + Sbjct: 273 YEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKH 324 >2WTK-B nrPDB Length = 373 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 111/313 (35%), Gaps = 73/313 (23%) Query: 195 LKLLQTIGKGEFG---DVMLGDYR--GNKVAVKCIKNDATAQA----FLAEASVMTQLRH 245 +LL IGKG F V L Y+ G V V+ I +A + E V H Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+V + + L++VT +MA GS D + + + + V +A++Y+ Sbjct: 70 PNIVPYRATFIAD-NELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYI 128 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---------TQDTGKLPVK---WT 353 +VHR + A ++L+S D +S GL S D K VK W Sbjct: 129 HHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWL 186 Query: 354 APEALRE--KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM------ 405 +PE L++ + + KSD++S GI E+ + G VP+ +P ++ G Sbjct: 187 SPEVLQQNLQGYDAKSDIYSVGITACELAN-GHVPFKDMPATQMLLEKLNGTVPCLLDTS 245 Query: 406 ----------------------------DAPDG-----------CPPAVYDVMKNCWHLD 426 P P + ++ C + Sbjct: 246 TIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRN 305 Query: 427 AATRPTFLQLREQ 439 RP+ L Sbjct: 306 PDARPSASTLLNH 318 >4IAN-A nrPDB Length = 358 Score = 157 bits (398), Expect = 8e-39, Method: Composition-based stats. Identities = 54/218 (24%), Positives = 99/218 (45%), Gaps = 16/218 (7%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR---GNKVAVKCIKNDATAQAF-LAEASVMTQLRHS-- 246 K + G+G F +V+ +VAVK I+N+ Q L E + +L + Sbjct: 30 KRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADP 89 Query: 247 ----NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEA 301 + ++L K L +V E ++ +L + L+ G+ V L + +S + A Sbjct: 90 DDKFHCLRLFRHFYH-KQHLCLVFEPLS-MNLREVLKKYGKDVGLHIKAVRSYSQQLFLA 147 Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVA-KVSDFGLTKEASSTQDTGKLPVK-WTAPEALR 359 ++ L+ N +H D+ N+LV+E K+ DFG + T L + + APE + Sbjct: 148 LKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIII 207 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVP 397 K + D+WS G L+E+Y+ G++ +P ++ Sbjct: 208 GKSYDYGIDMWSVGCTLYELYT-GKILFPGKTNNHMLK 244 >4JLC-A nrPDB Length = 657 Score = 156 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 54/232 (23%), Positives = 96/232 (41%), Gaps = 26/232 (11%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ AVK N + + + E V+ +L H N+V+L Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 71 Query: 252 LGVIVEEKG-GLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGNN 309 + E ++ E+ GSL L + L L DV M +L N Sbjct: 72 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 131 Query: 310 FVHRDLAARNVL--VSEDNV--AKVSDFGLTKEASSTQDTG--KLPVKWTAPEALR---- 359 VHRD+ N++ + ED K++DFG +E + ++ P+ Sbjct: 132 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 191 Query: 360 ----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP----LKDVVPRVEKGY 403 +KK+ D+WS G+ + + G +P+ K+V+ ++ G Sbjct: 192 RKDHQKKYGATVDLWSVGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 242 >4EUU-A nrPDB Length = 319 Score = 156 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 52/232 (22%), Positives = 96/232 (41%), Gaps = 26/232 (11%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 252 LGVIVEEKG-GLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGNN 309 + E ++ E+ GSL L + L L DV M +L N Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 310 FVHRDLAARNVL--VSEDNV--AKVSDFGLTKEASSTQDTG--KLPVKWTAPEALR---- 359 VHR++ N++ + ED K++DFG +E + ++ P+ Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 360 ----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP----LKDVVPRVEKGY 403 +KK+ D+WS G+ + + G +P+ K+V+ ++ G Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 243 >4NFN-A nrPDB Length = 309 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 110/266 (41%), Gaps = 18/266 (6%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQ 250 K+L+ IG G FG++ VA+K Q E +V+ +L+ + V Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVC 80 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 + Y+V + +L D RS+ R L+ + E++E + F Sbjct: 81 RFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 139 Query: 311 VHRDLAARNV----LVSEDNVAKVSDFGLTKEASSTQDTG---------KLPVKWTAPEA 357 +HRD+ N L S + DFGL ++ ++T + V++ + A Sbjct: 140 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNA 199 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA-PDGCPPAVY 416 + ++ D+WS +L E ++ G++P+ +I K+ V +++ Y+ P + Sbjct: 200 HKNREMGRHDDLWSLFYMLVE-FAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFH 258 Query: 417 DVMKNCWHLDAATRPTFLQLREQLEH 442 + + LD T+P + + E+ Sbjct: 259 LFLDHIASLDYFTKPDYQLIMSVFEN 284 >4EUT-A nrPDB Length = 396 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 52/232 (22%), Positives = 96/232 (41%), Gaps = 26/232 (11%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 252 LGVIVEEKG-GLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGNN 309 + E ++ E+ GSL L + L L DV M +L N Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 310 FVHRDLAARNVL--VSEDNV--AKVSDFGLTKEASSTQDTG--KLPVKWTAPEALR---- 359 VHR++ N++ + ED K++DFG +E + ++ P+ Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 360 ----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP----LKDVVPRVEKGY 403 +KK+ D+WS G+ + + G +P+ K+V+ ++ G Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 243 >4WOV-A nrPDB Length = 317 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 67/250 (26%), Positives = 108/250 (43%), Gaps = 28/250 (11%) Query: 212 GDYRGNK--VAVKCIKNDA--TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTE 267 G RG + V +K + A AF AS+M+Q+ H++L + GV V + +VTE Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI-MVTE 136 Query: 268 YMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV 327 Y+ G L +LR R R + + + + A+ YLE N VH ++ RN+L++ + Sbjct: 137 YVEHGPLDVWLR-RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 195 Query: 328 -------AKVSDFG-----LTKEASSTQDTGKLPVKWTAPEALREK--KFSTKSDVWSFG 373 K+SD G L++E + + W APE L ST D W FG Sbjct: 196 AEGTSPFIKLSDPGVGLGALSREERVER------IPWLAPECLPGGANSLSTAMDKWGFG 249 Query: 374 ILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTF 433 L EI G P + ++ +++ P CP + + C + RP+F Sbjct: 250 ATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CPQ-LATLTSQCLTYEPTQRPSF 307 Query: 434 LQLREQLEHI 443 + L + Sbjct: 308 RTILRDLTRL 317 >4M4Z-A nrPDB Length = 170 Score = 154 bits (390), Expect = 7e-38, Method: Composition-based stats. Identities = 55/173 (31%), Positives = 82/173 (47%), Gaps = 21/173 (12%) Query: 10 SGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQKR 68 S +A +F +L G+ LTIV ++D +W+ ++V GRE IP+ +V K Sbjct: 10 SKATAVALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKV 67 Query: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCE--- 123 W + ++RE+AE LL P G FL+RES G Y+L V Sbjct: 68 S----------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPA 117 Query: 124 --GKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVM 173 ++ HYRI L I + F +L LV+HY+ AD +C L +P V+ Sbjct: 118 SWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVL 170 >6O8B-A nrPDB Length = 665 Score = 154 bits (389), Expect = 8e-38, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 98/232 (42%), Gaps = 26/232 (11%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 78 Query: 252 LGVIVEEKG-GLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGNN 309 + E ++ E+ GSL L + L L DV M +L N Sbjct: 79 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 138 Query: 310 FVHRDLAARNVL--VSEDNV--AKVSDFGLTKEASSTQDTGKL--PVKWTAPEALR---- 359 VHR++ N++ + ED K++DFG +E + +L ++ P+ Sbjct: 139 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVL 198 Query: 360 ----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP----LKDVVPRVEKGY 403 +KK+ D+WS G+ + + G +P+ K+V+ ++ G Sbjct: 199 RKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 249 >6NT9-A nrPDB Length = 742 Score = 153 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 52/232 (22%), Positives = 96/232 (41%), Gaps = 26/232 (11%) Query: 197 LLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF---LAEASVMTQLRHSNLVQL 251 L +G+G +V G ++ G+ A+K N + + + E V+ +L H N+V+L Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 Query: 252 LGVIVEEKG-GLYIVTEYMAKGSLVDYLRSRGRSV-LGGDCLLKFSLDVCEAMEYLEGNN 309 + E ++ E+ GSL L + L L DV M +L N Sbjct: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 Query: 310 FVHRDLAARNVL--VSEDNV--AKVSDFGLTKEASSTQDTG--KLPVKWTAPEALR---- 359 VHR++ N++ + ED K++DFG +E + ++ P+ Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 Query: 360 ----EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIP----LKDVVPRVEKGY 403 +KK+ D+WS G+ + + G +P+ K+V+ ++ G Sbjct: 191 RKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 241 >3LLT-A nrPDB Length = 360 Score = 153 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 57/345 (16%), Positives = 122/345 (35%), Gaps = 82/345 (23%) Query: 173 MEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKN-DAT 229 +G ++ G LN +++ +G G FG V+L + NK AVK ++N Sbjct: 16 FQGDDEIVHFSWKKGMLLN-NAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKY 74 Query: 230 AQAFLAEASVMTQLRHSNL-----VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS 284 ++ EA ++ ++++ ++ V+ G + + ++ E + SL + + + Sbjct: 75 TRSAKIEADILKKIQNDDINNNNIVKYHGKFM-YYDHMCLIFEPL-GPSLYEIITRNNYN 132 Query: 285 VLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV----------------- 327 + + + +++ +A+ YL + H DL N+L+ + Sbjct: 133 GFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQ 192 Query: 328 --------AKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEI 379 K+ DFG S + ++ APE + + SD+WSFG +L E+ Sbjct: 193 IYRTKSTGIKLIDFGCATFKSDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAEL 252 Query: 380 YSFGRVPYPRIPLKDVVPRVE-------------------------KGYKMDAPDGCP-- 412 Y+ G + + + + +E K+ P+ Sbjct: 253 YT-GSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSI 311 Query: 413 ------------------PAVYDVMKNCWHLDAATRPTFLQLREQ 439 D + + +D RP+ +L + Sbjct: 312 NSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKH 356 >4CRL-A nrPDB Length = 406 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 41/205 (20%), Positives = 86/205 (41%), Gaps = 24/205 (11%) Query: 200 TIGKGEFGDVMLGDYRGNK----VAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVI 255 +G+G +G V + K A+K I+ + + E +++ +L+H N++ L V Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVF 88 Query: 256 VEEKGG-LYIVTEYMAKGSLVDYLR-------SRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 + ++++ +Y L ++ ++ L + + + + YL Sbjct: 89 LSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHA 147 Query: 308 NNFVHRDLAARNVLVS----EDNVAKVSDFGLTKEASS------TQDTGKLPVKWTAPEA 357 N +HRDL N+LV E K++D G + +S D + + APE Sbjct: 148 NWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPEL 207 Query: 358 LRE-KKFSTKSDVWSFGILLWEIYS 381 L + ++ D+W+ G + E+ + Sbjct: 208 LLGARHYTKAIDIWAIGCIFAELLT 232 >4I94-A nrPDB Length = 300 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 105/246 (42%), Gaps = 10/246 (4%) Query: 208 DVMLGDYRGNK-VAVKCIKND--ATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYI 264 V G + +AVK ++ FL EA + QLR+ + LLG E++ L + Sbjct: 44 VVYKGKLENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERL-L 102 Query: 265 VTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN-FVHRDLAARNVLVS 323 + E+M +L +L + L+ +L + +A+EY ++ DL A VL Sbjct: 103 IAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVLFD 162 Query: 324 EDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFG 383 +D ++S FGL K + + + +T PE LR + + +S ++SFG LL ++ S Sbjct: 163 DDANPRLSCFGLMKNSRDGKS-YSTNLAFTPPEYLRTGRVTPESVIYSFGTLLLDLLSGK 221 Query: 384 RVP----YPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 +P I +++ ++ G + + + C + RP L Sbjct: 222 HIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPNPKSLVSA 281 Query: 440 LEHIRT 445 + ++ Sbjct: 282 MIPLQK 287 >2H34-A nrPDB Length = 309 Score = 150 bits (380), Expect = 9e-37, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 101/265 (38%), Gaps = 21/265 (7%) Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ-----AF 233 D S +L + +G+G GDV + + VA+K + ++ Sbjct: 22 DGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRM 81 Query: 234 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 293 EA +L+ ++V + E G LY+ + L LR +G L + Sbjct: 82 QREARTAGRLQEPHVVPIHD-FGEIDGQLYVDMRLINGVDLAAMLRRQG--PLAPPRAVA 138 Query: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT----GKLP 349 + A++ HRD+ N+LVS D+ A + DFG+ + + T Sbjct: 139 IVRQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGT 198 Query: 350 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP- 408 + + APE E + ++D+++ +L+E + G PY L + + + + P Sbjct: 199 LYYMAPERFSESHATYRADIYALTCVLYECLT-GSPPYQGDQLSVMGAHINQ--AIPRPS 255 Query: 409 ---DGCPPAVYDVMKNCWHLDAATR 430 G P A V+ + R Sbjct: 256 TVRPGIPVAFDAVIARGMAKNPEDR 280 >4TN6-A nrPDB Length = 318 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 106/276 (38%), Gaps = 29/276 (10%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVK--CIKNDATAQAFLAEASVMTQLRHSNL 248 +L + IG G FGD+ LG G +VA+K C+K E+ + ++ Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI--ESKIYKMMQGGVG 64 Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 + + E +V E + SL D R +L + + +EY+ Sbjct: 65 IPTIRWCGAEGDYNVMVMELL-GPSLEDLFNFCSR-KFSLKTVLLLADQMISRIEYIHSK 122 Query: 309 NFVHRDLAARNVLV---SEDNVAKVSDFGLTKEASSTQDTGKLP----------VKWTAP 355 NF+HRD+ N L+ + N+ + DFGL K+ + +P ++ + Sbjct: 123 NFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASI 182 Query: 356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK--GYKMDAP----- 408 + S + D+ S G +L ++ G +P+ + + E+ KM P Sbjct: 183 NTHLGIEQSRRDDLESLGYVLM-YFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241 Query: 409 DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 G P + C L +P + LR+ ++ Sbjct: 242 KGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLF 277 >2PMN-X nrPDB Length = 348 Score = 147 bits (372), Expect = 8e-36, Method: Composition-based stats. Identities = 58/314 (18%), Positives = 117/314 (37%), Gaps = 57/314 (18%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNKVAVKC-------------------IKNDATAQA 232 + + ++++T+ +G+F ++L + A+K I + Sbjct: 30 INDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDD 89 Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDY------LRSRGRSVL 286 F E ++T +++ + G+I +YI+ EYM S++ + L + Sbjct: 90 FKNELQIITDIKNEYCLTCEGIITN-YDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFI 148 Query: 287 GGDCLLKFSLDVCEAMEYLE-GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT 345 + V + Y+ N HRD+ N+L+ ++ K+SDFG ++ + Sbjct: 149 PIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIK 208 Query: 346 G-KLPVKWTAPEAL-REKKF-STKSDVWSFGILLWEIYSFGRVPYP-RIPLKDVVPRVEK 401 G + ++ PE E + K D+WS GI L+ ++ + VP+ +I L ++ + Sbjct: 209 GSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMF-YNVVPFSLKISLVELFNNIRT 267 Query: 402 G---YKMDAPDGCPP---------------AVYDVMKNCWHLDAATRPTFLQLREQ---- 439 Y +D P D +K + A R T + Sbjct: 268 KNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHEWLA 327 Query: 440 ---LEHIRTHELHL 450 +E +R L Sbjct: 328 DTNIEDLREFSKEL 341 >5VDK-A nrPDB Length = 297 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 55/279 (19%), Positives = 97/279 (34%), Gaps = 39/279 (13%) Query: 193 KELKLLQTIGKGEFGDVMLG--DYRGNKVAVKC----IKNDATAQAFLAEASVMTQL-RH 245 KE ++ IG GEFG V G A+K + + L E L H Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV--LGGDCLLKFSLDVCEAME 303 ++V+ E+ + I EY GSL + +S L L + + Sbjct: 75 PHVVRYYSSWAED-DHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 133 Query: 304 YLEGNNFVHRDLAARNV-----------------------LVSEDNVAKVSDFGLTKEAS 340 Y+ ++ VH D+ N+ +S + + K+ D G + Sbjct: 134 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 193 Query: 341 STQDTGKLPVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 + + ++ A E L+E + K+D+++ G+ + +P + Sbjct: 194 KPK-VEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLP----TNGAAWHHI 248 Query: 400 EKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 KG D P + ++KN DA RP+ L Sbjct: 249 RKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALAR 287 >5FQD-C nrPDB Length = 341 Score = 145 bits (365), Expect = 6e-35, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 112/295 (37%), Gaps = 31/295 (10%) Query: 172 VMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDAT 229 M + ++ EF G + KL++ IG G FGD+ L G +VAVK A Sbjct: 4 RMASSSGSKAEFIVGG------KYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKAR 57 Query: 230 AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 L E+ + L+ + + +EK +V + + SL D R Sbjct: 58 HPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLL-GPSLEDLFNFCSRR-FTMK 115 Query: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA-K--VSDFGLTKEASSTQDTG 346 +L + + +EY+ NF+HRD+ N L+ K + DFGL K+ + Sbjct: 116 TVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQ 175 Query: 347 KLP----------VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396 +P ++ + A + S + D+ S G +L ++ +P+ + Sbjct: 176 HIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM-YFNRTSLPWQGLKAATKK 234 Query: 397 PRVEK--GYKMDAP-----DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 + EK KM P G P + C L P ++ LR+ + Sbjct: 235 QKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILF 289 >5X1R-A nrPDB Length = 302 Score = 142 bits (358), Expect = 4e-34, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 116/302 (38%), Gaps = 45/302 (14%) Query: 175 GTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG--NKVAVKC--------- 223 G SG+ N E ++ + IG+G FG V +A+K Sbjct: 5 GITKPNSNSLPSGYRFN--EFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKR 62 Query: 224 -------IKNDATAQ-------AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYM 269 ++ + + +F+ EA ++ + H L+ +L EE G Y+ T++ Sbjct: 63 NDDLSIGLRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLR-FWEENGTAYMGTQFY 121 Query: 270 AKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAK 329 + +L + L+++ + + + + A+ + ++HRD++ N+ + E + Sbjct: 122 SGTTLKN-LQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV 180 Query: 330 VSDFGLTKEA---SSTQDTGKLPVKWTAPEAL---REKKFSTKSDVWSFGILLWEIYSFG 383 + DFG ++ S + L + E + + +D+++ G +L + G Sbjct: 181 LLDFGSARKEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLI-VG 239 Query: 384 RVPYPRIPLKDVVPRVEKGYKM---DAPDGCPPAVYDVMKNCWHLDAATRP-TFLQLREQ 439 P VV +E Y+ P G P + + L RP T ++ E Sbjct: 240 SPP-----PVSVVRSIEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAEL 294 Query: 440 LE 441 LE Sbjct: 295 LE 296 >3QD2-B nrPDB Length = 332 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 57/336 (16%), Positives = 105/336 (31%), Gaps = 92/336 (27%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGN--KVAV-------------KCIKN---------- 226 + + + +Q +G+G FG V + + A+ K ++ Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHP 64 Query: 227 ----------DATAQAFLAE---------------------------ASVMTQLRHSNLV 249 + + + E M N V Sbjct: 65 GIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTV 124 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCL-LKFSLDVCEAMEYLEGN 308 L K LYI + K +L D++ R + L + + EA+E+L Sbjct: 125 GQLQ-PSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSK 183 Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---------------TQDTGKLPVKWT 353 +HRDL N+ + D+V KV DFGL T + Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAP----D 409 +PE + +S K D++S G++L+E+ Y + V + + P Sbjct: 244 SPEQIHGNNYSHKVDIFSLGLILFELL------YSFSTQMERVRIITDVRNLKFPLLFTQ 297 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLRE--QLEHI 443 P + ++++ RP + E E++ Sbjct: 298 KYPQE-HMMVQDMLSPSPTERPEATDIIENAIFENL 332 >3T04-A nrPDB Length = 123 Score = 138 bits (348), Expect = 5e-33, Method: Composition-based stats. Identities = 47/127 (37%), Positives = 62/127 (48%), Gaps = 9/127 (7%) Query: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120 P+NY+ L W+HG ++R AE LL G FLVRES + PG ++ + Sbjct: 3 PSNYITPVNS------LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISL 56 Query: 121 SCEGKVEHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDADGLCT--RLIKPKVMEGTV 177 EG+V HYRI KL + E F L +LV H++T ADGL T PK + TV Sbjct: 57 RYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 116 Query: 178 AAQDEFY 184 Y Sbjct: 117 YGVSPNY 123 >3SV0-A nrPDB Length = 483 Score = 138 bits (347), Expect = 6e-33, Method: Composition-based stats. Identities = 51/274 (18%), Positives = 99/274 (36%), Gaps = 25/274 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQ 250 + +L + IG G FG++ LG +VA+K L E+ + L+ + Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTGIP 66 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 + E +V + + SL D R L +L + + +E++ +F Sbjct: 67 NVRWFGVEGDYNVLVMDLL-GPSLEDLFNFCSR-KLSLKTVLMLADQMINRVEFVHSKSF 124 Query: 311 VHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLP----------VKWTAPEA 357 +HRD+ N L+ N + DFGL K+ T +P ++ + Sbjct: 125 LHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASVNT 184 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL---KDVVPRVEKGYKMDAPD----G 410 + S + D+ S G +L + G +P+ + K ++ + + + G Sbjct: 185 HLGIEQSRRDDLESLGYVLM-YFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEALCRG 243 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 P C L +P + L+ + Sbjct: 244 YPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLF 277 >2JD5-A nrPDB Length = 373 Score = 137 bits (346), Expect = 9e-33, Method: Composition-based stats. Identities = 49/334 (14%), Positives = 106/334 (31%), Gaps = 77/334 (23%) Query: 194 ELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDAT-AQAFLAEASVMTQLRH----- 245 L++ +G G F V L VA+K ++ D +A E ++ ++ Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK 79 Query: 246 ------SNLVQLLGVI-VEEKGGLYIVTEY-MAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 +++++LL + G+++V + + +L+ ++ + + + S Sbjct: 80 EDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQ 139 Query: 298 VCEAMEYLEGN-NFVHRDLAARNVL---VSEDN---VAKVSDFGLTKEASSTQDTGKLPV 350 + ++Y+ +H D+ NVL V K++D G Sbjct: 140 LLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQTR 199 Query: 351 KWTAPEALREKKFSTKSDVWSFGILLWEIYS--------------------------FGR 384 ++ +PE L + +D+WS L++E+ + G Sbjct: 200 EYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGE 259 Query: 385 VPYPRI----------PLKDVVPRVEKGYKMDAPDGCPP----------AVYDVMKNCWH 424 +P + + ++ + K D + D + Sbjct: 260 LPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQ 319 Query: 425 LDAATRPTFLQLREQ--------LEHIRTHELHL 450 LD R L +E IR + L Sbjct: 320 LDPRKRADAGGLVNHPWLKDTLGMEEIRVPDREL 353 >4LQP-A nrPDB Length = 508 Score = 136 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 38/163 (23%), Positives = 67/163 (41%), Gaps = 10/163 (6%) Query: 193 KELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQ-----AFLAEASVMTQLRH 245 ++ ++ IGKG FG+V L G A+K + + AE V+ Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 +V L ++ LY++ E++ G L+ L + D + + A+E + Sbjct: 162 PWVVSLY-YSFQDAQYLYLIMEFLPGGDLMTMLIRW--QLFTEDVTRFYMAECILAIETI 218 Query: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL 348 F+HR + N+L+ K+SDFGL+ T D+ Sbjct: 219 HKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYY 261 Score = 74.5 bits (182), Expect = 8e-14, Method: Composition-based stats. Identities = 14/90 (15%), Positives = 32/90 (35%), Gaps = 5/90 (5%) Query: 344 DTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV---E 400 + + APE + + + D WS G +++E G P+ ++ ++ E Sbjct: 321 YSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECL-IGWPPFCSETPQETYRKIMNFE 379 Query: 401 KGYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 + + D+++ A R Sbjct: 380 QTLQFPDDIHISYEAEDLIRRLLTH-ADQR 408 >4L68-A nrPDB Length = 340 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 104/265 (39%), Gaps = 29/265 (10%) Query: 205 EFGDVMLGDY-RGNKVAVKCIKNDATAQA-FLAEASVMTQLRHSNLVQLLGVIVEEKGGL 262 G G+ +AVK + + F E + + +LRHSNL LLG V E+ Sbjct: 52 RTGTTYKALLPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEK- 110 Query: 263 YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG---NNFVHRDLAARN 319 ++V +YM+ G+L L S R L + L + +L +H+++ + Sbjct: 111 FLVYKYMSNGTLHSLLDS-NRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSV 169 Query: 320 VLVSEDNVAKVSDFGLTK-------EASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSF 372 +L+ ED A++ D GL + SS + APE S K DV+ Sbjct: 170 ILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGL 229 Query: 373 GILLWEIYS----FGRVPYPRIPLKDVVPRVEKGYKMD-------APDGCPPAVYDVMK- 420 G++L E+ + G + L D V ++E ++ G + ++ Sbjct: 230 GVVLLELATGLKAVGGEGFKG-SLVDWVKQLESSGRIAETFDENIRGKGHDEEISKFVEI 288 Query: 421 --NCWHLDAATRPTFLQLREQLEHI 443 NC R + Q + L+ I Sbjct: 289 ALNCVSSRPKERWSMFQAYQSLKAI 313 >6EAS-A nrPDB Length = 308 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 122/307 (39%), Gaps = 44/307 (14%) Query: 168 IKPKVMEGTVAAQDEFYRSGWALNMKELK-----LLQTIGKGEFGDVMLGDYR-GNKVAV 221 ++P + Q F +L EL+ IG + G G ++AV Sbjct: 10 VRPWATGLSGQLQKAFVTGVPSLKRSELETACEDFSNIIGSTSTCMLYKGTLSSGVEIAV 69 Query: 222 --------KCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGL-YIVTEYMAKG 272 K + +Q + + + ++++ H N + LLG EE +V EY G Sbjct: 70 ASSLVTSAKDWSKENESQ-YRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNG 128 Query: 273 SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN--NFVHRDLAARNVLVSEDNVAKV 330 +L ++L R L L+ S+ + +E++ R+ + V +++D AKV Sbjct: 129 TLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKV 188 Query: 331 SDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSD--VWSFGILLWEIYSFGRVPYP 388 SD +A T E FS + V +G++L EI + GRVP Sbjct: 189 SDLEFWNDAKGHNSTTN-----------NELAFSPDMEDIVRKYGMVLLEILT-GRVPSS 236 Query: 389 RI--PLKDVVPR-VEKGYKMDA---------PDGCPPAVYDVMKNCWHLDAATRPTFLQL 436 PL++ V R E G +++ P+ A+ +V+++C D RP ++ Sbjct: 237 EDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 Query: 437 REQLEHI 443 ++ I Sbjct: 297 AARMREI 303 >2PVN-A nrPDB Length = 352 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 43/294 (14%), Positives = 102/294 (34%), Gaps = 52/294 (17%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH----S 246 + ++++ +G+G++ +V G N KCI + L++ Sbjct: 50 EQDDYEVVRKVGRGKYSEVFEGINVNNN--EKCIIKILKPVKKKKIKREIKILQNLCGGP 107 Query: 247 NLVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 N+V+LL ++ ++ ++ EY+ L L + + ++ +A++Y Sbjct: 108 NIVKLLDIVRDQHSKTPSLIFEYVNNTD-FKVLY----PTLTDYDIRYYIYELLKALDYC 162 Query: 306 EGNNFVHRDLAARNVLVSEDNV-AKVSDFGLTKEASSTQD-TGKLPVKW-TAPEALRE-K 361 +HRD+ NV++ + ++ D+GL + ++ ++ ++ PE L + + Sbjct: 163 HSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQ 222 Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK------------GYKMDAPD 409 + D+WS G + + + D + ++ K Y+++ Sbjct: 223 DYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDP 282 Query: 410 G------------------------CPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 P D + D R T L+ Sbjct: 283 QLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTH 336 >6HMD-A nrPDB Length = 365 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 102/292 (34%), Gaps = 48/292 (16%) Query: 191 NMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQAFLAEASVMTQLRH-SNL 248 N + +L++ +G+G++ +V N+ V I + E ++ LR +N+ Sbjct: 51 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 110 Query: 249 VQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 ++L+ + + +V EY+ +L + + ++ +A++Y Sbjct: 111 IKLIDTVKDPVSKTPALVFEYINNTDFKQL-----YQILTDFDIRFYMYELLKALDYCHS 165 Query: 308 NNFVHRDLAARNVLVSE-DNVAKVSDFGLTKEASSTQD-TGKLPVKW-TAPEAL-REKKF 363 +HRD+ NV++ ++ D+GL + Q+ ++ ++ PE L + + Sbjct: 166 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 225 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE------------KGYKMDAPDGC 411 D+WS G +L + + D + R+ K Y +D Sbjct: 226 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 285 Query: 412 ------------------------PPAVYDVMKNCWHLDAATRPTFLQLREQ 439 P D++ D R T + E Sbjct: 286 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 337 >4MD7-E nrPDB Length = 391 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 46/307 (14%), Positives = 105/307 (34%), Gaps = 52/307 (16%) Query: 180 QDEFYRSGWAL----NMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQAFL 234 E++ + N + +L++ +G+G++ +V N+ V I + Sbjct: 20 PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK 79 Query: 235 AEASVMTQLRH-SNLVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 E ++ LR N++ L ++ + +V E++ L + Sbjct: 80 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL-----YQTLTDYDIR 134 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV-AKVSDFGLTKEASSTQD-TGKLPV 350 + ++ +A++Y +HRD+ NV++ ++ ++ D+GL + Q+ ++ Sbjct: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 Query: 351 KW-TAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK------- 401 ++ PE L + + D+WS G +L + + D + R+ K Sbjct: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 Query: 402 -----GYKMDAPDGC------------------------PPAVYDVMKNCWHLDAATRPT 432 Y ++ P D + D +R T Sbjct: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 314 Query: 433 FLQLREQ 439 + E Sbjct: 315 AREAMEH 321 >4WUA-A nrPDB Length = 401 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 46/265 (17%), Positives = 91/265 (34%), Gaps = 66/265 (24%) Query: 194 ELKLLQTIGKGEFGDVMLG-DYRGNK-VAVKCIKN-DATAQAFLAEASVMTQLRH----- 245 +++ +G G F V L D +G K VA+K +K+ + + L E ++ +R+ Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 101 Query: 246 SN---LVQLLGVI---VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 N +VQLL + +V E + L+ ++ L C+ K V Sbjct: 102 PNREMVVQLLDDFKISGVNGTHICMVFEVLGH-HLLKWIIKSNYQGLPLPCVKKIIQQVL 160 Query: 300 EAMEYLEGN-NFVHRDLAARNVLVS----------------------------------- 323 + ++YL +H D+ N+L+S Sbjct: 161 QGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPAT 220 Query: 324 --------------EDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDV 369 E K++D G ++ + E L ++T +D+ Sbjct: 221 AGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADI 280 Query: 370 WSFGILLWEIYSFGRVPYPRIPLKD 394 WS + +E+ + G + ++ Sbjct: 281 WSTACMAFELAT-GDYLFEPHSGEE 304 >6EII-A nrPDB Length = 352 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 46/307 (14%), Positives = 105/307 (34%), Gaps = 52/307 (16%) Query: 180 QDEFYRSGWAL----NMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIKNDATAQAFL 234 E++ + N + +L++ +G+G++ +V N+ V I + Sbjct: 43 PSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIK 102 Query: 235 AEASVMTQLRH-SNLVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 E ++ LR N++ L ++ + +V E++ L + Sbjct: 103 REIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL-----YQTLTDYDIR 157 Query: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV-AKVSDFGLTKEASSTQD-TGKLPV 350 + ++ +A++Y +HRD+ NV++ ++ ++ D+GL + Q+ ++ Sbjct: 158 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 217 Query: 351 KW-TAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK------- 401 ++ PE L + + D+WS G +L + + D + R+ K Sbjct: 218 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 277 Query: 402 -----GYKMDAPDGC------------------------PPAVYDVMKNCWHLDAATRPT 432 Y ++ P D + D +R T Sbjct: 278 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT 337 Query: 433 FLQLREQ 439 + E Sbjct: 338 AREAMEH 344 >4F9B-A nrPDB Length = 361 Score = 128 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 48/239 (20%), Positives = 85/239 (35%), Gaps = 48/239 (20%) Query: 195 LKLLQTIGKGEFGDVMLGDYR-----GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLV 249 K+ IG+G F V L + K+A+K + + AE +T + V Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV 82 Query: 250 QLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 + + + I Y+ S +D L S L + ++ L++ +A++ + Sbjct: 83 MGVKYCFRKNDHVVIAMPYLEHESFLDILNS-----LSFQEVREYMLNLFKALKRIHQFG 137 Query: 310 FVHRDLAARNVLVSEDNVAK---VSDFGLTKEASSTQ----------------------- 343 VHRD+ N L + K + DFGL + T+ Sbjct: 138 IVHRDVKPSNFLYNRR--LKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSI 195 Query: 344 --------DTGKLPVKWTAPEALREKK-FSTKSDVWSFGILLWEIYSFGRVPYPRIPLK 393 + APE L + +T D+WS G++ + S GR P+ + Sbjct: 196 CLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLS-GRYPFYKASDD 253 >5XVU-A nrPDB Length = 332 Score = 128 bits (322), Expect = 6e-30, Method: Composition-based stats. Identities = 42/290 (14%), Positives = 94/290 (32%), Gaps = 48/290 (16%) Query: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQ 250 ++++ IG+G++ +V G A+K +K + + N+++ Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKKKKIKREIKILQNLNGGPNIIK 90 Query: 251 LLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 LL ++ + ++ EY+ + + + +A++Y Sbjct: 91 LLDIVKDPVTKTPSLIFEYINNIDFKTL-----YPKFTDKDIRYYIYQILKALDYCHSQG 145 Query: 310 FVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALRE-KKFST 365 +HRD+ N+++ E+ ++ +GL + Q+ + PE L + + + Sbjct: 146 IMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDLQLYDY 205 Query: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK------------------------ 401 D+WS G +L + + D + ++ K Sbjct: 206 SLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKPHYLN 265 Query: 402 --GYKMDAP----------DGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 G P D V D++ D A R + E Sbjct: 266 ILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEH 315 >4XHH-A nrPDB Length = 403 Score = 127 bits (320), Expect = 9e-30, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 102/273 (37%), Gaps = 25/273 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQ 250 ++ ++ + IG G FGD+ G G +VA++ + E+ V L + Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIP 66 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 + E +V + + SL D R ++ +L + ++Y+ G +F Sbjct: 67 FIRWFGREGEYNAMVIDLL-GPSLEDLFNYCHR-KFSFKTVIMLALQMICRVQYIHGRSF 124 Query: 311 VHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLP----------VKWTAPEA 357 +HRD+ N L+ + V DFGL+K+ +P ++ + Sbjct: 125 IHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNT 184 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL---KDVVPRVEKGYK----MDAPDG 410 + S + D+ S G +L + G +P+ + K R+ + G Sbjct: 185 HLGIEQSRRDDLESLGYMLI-YFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAG 243 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 P + M C +L RP +L L + + Sbjct: 244 LPLEFSEYMNYCRNLKFDERPDYLYLARLFKDL 276 >2X7G-A nrPDB Length = 389 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 44/263 (16%), Positives = 87/263 (33%), Gaps = 64/263 (24%) Query: 194 ELKLLQTIGKGEFGDVMLG-DYRGNK-VAVKCIKN-DATAQAFLAEASVMTQLR-----H 245 +++ +G G F V L D +G + VA+K +K+ + L E ++ +R Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 91 Query: 246 SN---LVQLLGVI---VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 N +VQL+ + +V E + L+ ++ L C+ V Sbjct: 92 PNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH-HLLKWIIKSNYQGLPVRCVKSIIRQVL 150 Query: 300 EAMEYLEGN-NFVHRDLAARNVL------------------------------------- 321 + ++YL +H D+ N+L Sbjct: 151 QGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAA 210 Query: 322 ------VSEDN----VAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWS 371 + N K++D G ++ + E L +ST +D+WS Sbjct: 211 DLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWS 270 Query: 372 FGILLWEIYSFGRVPYPRIPLKD 394 + +E+ + G + +D Sbjct: 271 TACMAFELAT-GDYLFEPHSGED 292 >5UV4-A nrPDB Length = 311 Score = 124 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 120/295 (40%), Gaps = 38/295 (12%) Query: 183 FYRSGWALNMKELKLL--QTIGKGEFGDVMLGDY-RGNKVAVKCIKND--ATAQAFLAEA 237 + + +EL + IG+ G G + VK +K + + F E Sbjct: 13 LFDNSVVFTAEELSCAPAEIIGRSCHGTSYKATLDNGYMLTVKWLKEGFAKSKKEFSREI 72 Query: 238 SVMTQLRHSNLVQLLGVIVEEKGGLYI-VTEYMAKGSLVDYL---RSRGRSVLGGDCLLK 293 + +RH NLV L G K I +++Y SL YL R L L Sbjct: 73 KKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLN 132 Query: 294 FSLDVCEAMEYLEGNNFV-HRDLAARNVLV-SEDNVAKVSDFGLTKEASSTQDTGKL--- 348 ++D+ ++YL + H ++ + NVL+ + A V+D+ L + + ++ Sbjct: 133 IAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNA 192 Query: 349 -PVKWTAPEALREKK--FSTKSDVWSFGILLWEIYSF---GRV---------PYPRIPLK 393 + ++ PE K S KSDV++FG++L E+ + G + + + Sbjct: 193 GALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTGKIAGEIICMNDGVVDLTDWVRML 252 Query: 394 DVVPRVEKGYK-----MDAPDGCPPAVYDVMK---NCWHLDAATRPTFLQLREQL 440 D+ RV + Y +++ +G P A+ +++ C A+ RP + E L Sbjct: 253 DLEERVSECYDRHITGVESSEGAPQALDGMLRIALRCI-RSASERPEVRTVFEDL 306 >5L2Q-C nrPDB Length = 320 Score = 124 bits (313), Expect = 6e-29, Method: Composition-based stats. Identities = 38/201 (18%), Positives = 79/201 (39%), Gaps = 19/201 (9%) Query: 259 KGGLYIVTEYMAKGS----------LVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 K + +V + + L Y+ R L + DV +E L Sbjct: 115 KKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKR--LSERETVVIFYDVVRVVEALHQK 172 Query: 309 NFVHRDLAARNVLVSEDNV-AKVSDFGLTKEASSTQD---TGKLPVKWTAPEALREKKF- 363 N VHRDL N+++++ +++F L K S D + + +P+ L + + Sbjct: 173 NIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYR 232 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYDVMKNC 422 SD+W+ G++L+ + +G+ P+ +++ +++ Y + +++ Sbjct: 233 GKPSDMWALGVVLFTML-YGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKL 291 Query: 423 WHLDAATRPTFLQLREQLEHI 443 LD R + E L I Sbjct: 292 LVLDPQQRLAAADVLEALSAI 312 >5M07-A nrPDB Length = 276 Score = 123 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 44/255 (17%), Positives = 92/255 (36%), Gaps = 35/255 (13%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK-----NDATAQAFLAEASVMTQ 242 + +++ +G G+V L + G A+K + +D + F E V + Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAAR 86 Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 L H +++++ E G L+I +Y+ ++ R +VL +L V A+ Sbjct: 87 LFHPHILEVHDR-GEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 303 EYLEGNNFVHRDLAARNVLVSE----DNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEAL 358 +Y +HRD+ NV+++ D ++DFG+ + + APE Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------PSYPAPELS 194 Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 ++D ++ + +++ G P V + P + + Sbjct: 195 AGADVDGRADQYALALTAIHLFA-GAPP--------VDRSHTGPLQPPKLSAFRPDLARL 245 Query: 419 ---MKNCWHLDAATR 430 + A R Sbjct: 246 DGVLSRALATAPADR 260 >6DC0-A nrPDB Length = 292 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 46/236 (19%), Positives = 90/236 (38%), Gaps = 16/236 (6%) Query: 211 LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMA 270 L + G ++ K + HSN+ ++ VI+ E Y+ E Sbjct: 26 LCIHTGRELRCKVFPIKHYQDKIRPYIQL---PSHSNITGIVEVILGETKA-YVFFEK-D 80 Query: 271 KGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS--EDNVA 328 G + Y+RSR R L + + + A+ + + V DL R + S E Sbjct: 81 FGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQL 138 Query: 329 K---VSDFGLTKEASSTQDTGKLPVKWTAPEALR-EKKFSTK-SDVWSFGILLWEIYSFG 383 + + D + K + +PE L +S K +DVWS G++L+ + G Sbjct: 139 RLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLL-VG 197 Query: 384 RVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 R P+ + ++ +G + P+ P ++++ + + R T ++ Sbjct: 198 RYPFHDSDPSALFSKIRRG-QFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 252 >5CEK-A nrPDB Length = 263 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 46/236 (19%), Positives = 90/236 (38%), Gaps = 16/236 (6%) Query: 211 LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMA 270 L + G ++ K + HSN+ ++ VI+ E Y+ E Sbjct: 29 LCIHTGRELRCKVFPIKHYQDKIRPYIQL---PSHSNITGIVEVILGETKA-YVFFEK-D 83 Query: 271 KGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS--EDNVA 328 G + Y+RSR R L + + + A+ + + V DL R + S E Sbjct: 84 FGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQL 141 Query: 329 K---VSDFGLTKEASSTQDTGKLPVKWTAPEALR-EKKFSTK-SDVWSFGILLWEIYSFG 383 + + D + K + +PE L +S K +DVWS G++L+ + G Sbjct: 142 RLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLL-VG 200 Query: 384 RVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 R P+ + ++ +G + P+ P ++++ + + R T ++ Sbjct: 201 RYPFHDSDPSALFSKIRRG-QFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 255 >2C47-A nrPDB Length = 313 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 52/276 (18%), Positives = 101/276 (36%), Gaps = 29/276 (10%) Query: 194 ELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQL 251 ++ + IG G FG++ LG Y VA+K + A E QL + V Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQ 64 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 + +V E + SL D R +L ++ + MEY+ + + Sbjct: 65 VYYFGPCGKYNAMVLELL-GPSLEDLFDLCDR-TFTLKTVLMIAIQLITRMEYVHTKSLI 122 Query: 312 HRDLAARNVLVSEDNV-----AKVSDFGLTKEASSTQDTGKLP----------VKWTAPE 356 +RD+ N LV + DFGL KE + +P ++ + Sbjct: 123 YRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 182 Query: 357 ALREKKFSTKSDVWSFG-ILLWEIYSFGRVPYPRI---PLKDVVPRVEKGYKMDAP---- 408 K+ S + D+ + G + ++ + G +P+ + LK+ ++ + Sbjct: 183 THLGKEQSRRDDLEALGHMFMY--FLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLC 240 Query: 409 DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 + P + ++ LD +P + LR+ + Sbjct: 241 ENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 276 >2CHL-A nrPDB Length = 351 Score = 121 bits (304), Expect = 5e-28, Method: Composition-based stats. Identities = 52/275 (18%), Positives = 101/275 (36%), Gaps = 28/275 (10%) Query: 194 ELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQL 251 ++ + IG G FG++ LG Y VA+K + A E QL + + Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQ 90 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 + +V E + SL D R +L ++ + MEY+ N + Sbjct: 91 VYYFGPCGKYNAMVLELL-GPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLI 148 Query: 312 HRDLAARNVLVSEDN-----VAKVSDFGLTKEASSTQDTGKLP----------VKWTAPE 356 +RD+ N L+ V + DF L KE + +P ++ + Sbjct: 149 YRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSIN 208 Query: 357 ALREKKFSTKSDVWSFG-ILLWEIYSFGRVPYPRI---PLKDVVPRVEKGYK-MDAPDGC 411 K+ S + D+ + G + ++ + G +P+ + LK+ ++ + C Sbjct: 209 THLGKEQSRRDDLEALGHMFMY--FLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLC 266 Query: 412 P--PAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 P + ++ LD +P + LR+ + Sbjct: 267 ENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 301 >2CMW-A nrPDB Length = 310 Score = 121 bits (304), Expect = 7e-28, Method: Composition-based stats. Identities = 52/278 (18%), Positives = 102/278 (36%), Gaps = 30/278 (10%) Query: 196 KLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNL-VQLL 252 ++ + IG G FG++ LG Y VA+K + A E QL + + + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQV 62 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 +V E + SL D R +L ++ + MEY+ N ++ Sbjct: 63 YYFGPCGKYNAMVLELL-GPSLEDLFDLCDR-TFTLKTVLMIAIQLLSRMEYVHSKNLIY 120 Query: 313 RDLAARNVLVSEDNVAK-----VSDFGLTKEASSTQDTGKLP----------VKWTAPEA 357 RD+ N L+ K + DFGL KE + +P ++ + Sbjct: 121 RDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINT 180 Query: 358 LREKKFSTKSDVWSFG-ILLWEIYSFGRVPYPRI---PLKDVVPRVEKGYKMDAP----D 409 K+ S + D+ + G + ++ + G +P+ + LK+ ++ + + Sbjct: 181 HLGKEQSRRDDLEALGHMFMY--FLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCE 238 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHE 447 P + ++ LD +P + LR + + Sbjct: 239 NFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKK 276 >4XHL-A nrPDB Length = 394 Score = 118 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 104/273 (38%), Gaps = 25/273 (9%) Query: 193 KELKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQ 250 ++ ++ + IG G FGD+ G G +VA++ + E+ V L + Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIP 66 Query: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 + E +V + + SL D R ++ +L + ++Y+ G +F Sbjct: 67 FIRWFGREGEYNAMVIDLL-GPSLEDLFNYCHRR-FSFKTVIMLALQMFCRIQYIHGRSF 124 Query: 311 VHRDLAARNVLVS---EDNVAKVSDFGLTKEASSTQDTGKLP----------VKWTAPEA 357 +HRD+ N L+ + V DFGL+K+ +P ++ + Sbjct: 125 IHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNT 184 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL---KDVVPRVEKGYKMDAPD----G 410 + S + D+ S G +L + G +P+ + K R+ + + + G Sbjct: 185 HLGIEQSRRDDLESLGYVLI-YFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSG 243 Query: 411 CPPAVYDVMKNCWHLDAATRPTFLQLREQLEHI 443 P + M C +L +P +L L + + Sbjct: 244 LPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDL 276 >4LFI-A nrPDB Length = 374 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 52/359 (14%), Positives = 114/359 (31%), Gaps = 92/359 (25%) Query: 164 CTRLIKPKVMEGTVAAQ-DEFYRSG-----WALNMKELKLLQTIGKGEFGDVMLGDYRGN 217 C + +V + +E++ W+ N K+ ++ +G+G++ +V G + Sbjct: 5 CRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDS 64 Query: 218 KVAVKC--------------------IKNDATAQAFL----------AEASVMTQLR--- 244 KV + + N+ L + V+ +R Sbjct: 65 KVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYI 124 Query: 245 -------HSNLVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296 H+N++ L +I + +V EY+ L + + Sbjct: 125 FDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRIL-----YPKLTDLEIRFYMF 179 Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSE-DNVAKVSDFGLTKEASSTQD--TGKLPVKWT 353 ++ +A++Y +HRD+ NV++ + ++ D+GL + + + Sbjct: 180 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFK 239 Query: 354 APEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK----------- 401 PE L + + D+WSFG +L + + D + ++ K Sbjct: 240 GPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYL 299 Query: 402 -GYKMDAPDGC------------------------PPAVYDVMKNCWHLDAATRPTFLQ 435 Y++ P + D++ N D R T + Sbjct: 300 LKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKE 358 >1A81-A nrPDB Length = 254 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 51/108 (47%), Positives = 62/108 (57%), Gaps = 4/108 (3%) Query: 67 KREGVKAGTKLSLMPWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCEG 124 + E + A T MPWFHGKI+RE++E+ L+ G FL+R N G Y LC+ EG Sbjct: 145 QLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEG 203 Query: 125 KVEHYRIMYH-ASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPK 171 KV HYRI KLSI E F+ L QLVEHY+ ADGL L P Sbjct: 204 KVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 251 Score = 77.6 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 3/118 (2%) Query: 81 PWFHGKITREQAERLLYPPE--TGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH-ASK 137 P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I Sbjct: 6 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 65 Query: 138 LSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKEL 195 +I + L +++ ++DGL L KP V + + ++E Sbjct: 66 YAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREY 123 >4NT4-A nrPDB Length = 312 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 103/282 (36%), Gaps = 35/282 (12%) Query: 194 ELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQAFLAEASVMTQL-RHSN--- 247 ++ + IG G FG++ LG Y VA+K + A E L H++ Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 72 Query: 248 --LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 + ++ + +V E + SL D R +L + + +EY+ Sbjct: 73 DGIPRIYHLGTCGGRYNAMVLELL-GLSLEDLFNICAR-KFSLKTVLMIAKQLLHRIEYV 130 Query: 306 EGNNFVHRDLAARNVLV-----SEDNVAKVSDFGLTKEASSTQDTGKLP----------V 350 + ++RD+ N L+ + + + DFGL KE +P Sbjct: 131 HSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTA 190 Query: 351 KWTAPEALREKKFSTKSDVWSFG-ILLWEIYSFGRVPYPRI---PLKDVVPRVEKGYKMD 406 ++ + ++ S + D+ + G + ++ + G +P+ + LK+ ++ + Sbjct: 191 RYMSINTHMGREQSRRDDLEALGHMFMY--FLRGSLPWQGLKADTLKERYQKIGDTKRAT 248 Query: 407 AP----DGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 DG P ++ LD P + LR + + Sbjct: 249 PIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLF 290 >5X18-A nrPDB Length = 295 Score = 115 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 89/244 (36%), Gaps = 30/244 (12%) Query: 195 LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLL 252 K+ + IG+G FG + G G VA+K A E L + + Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYA 68 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 +E +V + + SL D GR +++ ++ + +E L ++ ++ Sbjct: 69 YYFGQEGLHNILVIDLL-GPSLEDLFDWCGR-KFSVKTVVQVAVQMITLIEDLHAHDLIY 126 Query: 313 RDLAARNVLVSEDNV-----AKVSDFGLTKEASSTQDTGKLP----------VKWTAPEA 357 RD+ N L+ + DFG+ K+ + +P ++ + Sbjct: 127 RDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINT 186 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI---PLKDVVPRVEKGYKMDAPDGCPPA 414 ++ S + D+ + G + + + G +P+ + K ++ + + Sbjct: 187 HLGREQSRRDDMEALGHVFF-YFLRGHLPWQGLKAPNNKQKYEKIGEKKR-------STN 238 Query: 415 VYDV 418 VYD+ Sbjct: 239 VYDL 242 >6J6I-B nrPDB Length = 351 Score = 114 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 100/273 (36%), Gaps = 41/273 (15%) Query: 210 MLGDYRGNKVAVKCIKNDA------TAQAFLAEASVMTQL-RHSNLVQLLGVIVEEKGGL 262 G+ +K D + + + ++ HSN +QLLG +E + Sbjct: 75 YRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPV 134 Query: 263 YIVTEYMAKGSLVD---YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG---NNFVHRDLA 316 +V E+ G++ + + S+L LK ++ A+ YL +HRD+ Sbjct: 135 -LVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVK 193 Query: 317 ARNVLVSEDNVAKVSDFGLTKEASSTQDTGK-----LPVKWTAPEALREKKFSTKSDVWS 371 +V + ++ AK+SD + + + + P + + +DV+S Sbjct: 194 PMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYS 253 Query: 372 FGILLWEIYSFGRVPYPRIPLKD------VVPRVEKGYKMDAPDGCPPAVYD-------- 417 FGI L I + G+ I D +V + + K+D P + D Sbjct: 254 FGICLLVIIT-GKPAIMTISDGDLQGILSLVRELCENGKLDEVID-PRLMKDITSGQRLQ 311 Query: 418 ------VMKNCWHLDAATRPTFLQLREQLEHIR 444 + C RP +Q+ ++L+ I Sbjct: 312 VEACVVLALRCCKERDEDRPKMIQVAKELKQIE 344 >2PZI-A nrPDB Length = 681 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 49/253 (19%), Positives = 95/253 (37%), Gaps = 27/253 (10%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR---GNKVAVKCIKNDATAQAFLAE---ASVMTQLRHSN 247 + ++ I G G + L R G V +K + + A+A + ++ H + Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPS 140 Query: 248 LVQLLGVIVEEKGGL----YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 +VQ+ + YIV EY+ SL + L + + L++ A+ Sbjct: 141 IVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIAYLLEILPALS 196 Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKF 363 YL V+ DL N++++E+ K+ D G +S + APE +R Sbjct: 197 YLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYL-YGTPGFQAPEIVRTGP- 253 Query: 364 STKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD-GCPPAVYDVMKNC 422 + +D+++ G L + +P ++ R G D P + +++ Sbjct: 254 TVATDIYTVGRTLAALTL-------DLPTRN--GRYVDGLPEDDPVLKTYDSYGRLLRRA 304 Query: 423 WHLDAATRPTFLQ 435 D R T + Sbjct: 305 IDPDPRQRFTTAE 317 >4Y12-A nrPDB Length = 375 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 52/259 (20%), Positives = 95/259 (36%), Gaps = 39/259 (15%) Query: 194 ELKLLQTIGKGEFGDVMLGDYR---GNKVAVKCIKNDATA---------QAFLAEASVMT 241 + ++ I G G + L R G V +K + + A + FLAE Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV--- 176 Query: 242 QLRHSNLVQLLGVIVEEKGGL----YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 H ++VQ+ + YIV EY+ SL + L + + L+ Sbjct: 177 ---HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIAYLLE 229 Query: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEA 357 + A+ YL V+ DL N++++E+ K+ D G +S + APE Sbjct: 230 ILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYL-YGTPGFQAPEI 287 Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD-GCPPAVY 416 +R + +D+++ G L + +P ++ R G D P + Sbjct: 288 VRTGP-TVATDIYTVGRTLAALTL-------DLPTRN--GRYVDGLPEDDPVLKTYDSYG 337 Query: 417 DVMKNCWHLDAATRPTFLQ 435 +++ D R T + Sbjct: 338 RLLRRAIDPDPRQRFTTAE 356 >6CMQ-A nrPDB Length = 427 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 45/160 (28%), Positives = 66/160 (41%), Gaps = 34/160 (21%) Query: 80 MPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCE----------GKVEH 128 WFHG ++ ++AE+LL G FLVRES ++PGD+ L V KV H Sbjct: 8 ERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTH 67 Query: 129 YRIMYHASKLSIDEEVYFENLMQLVEHYTTD----ADGLCTRLIKP-------------- 170 I K + F++L LVEHY + G +L +P Sbjct: 68 VMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESR 127 Query: 171 -----KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGE 205 K+ E T + F+ L +E KLL + +G+ Sbjct: 128 VRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQ 167 >4H1O-A nrPDB Length = 560 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 45/160 (28%), Positives = 66/160 (41%), Gaps = 34/160 (21%) Query: 80 MPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCE----------GKVEH 128 WFHG ++ ++AE+LL G FLVRES ++PGD+ L V KV H Sbjct: 131 ERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTH 190 Query: 129 YRIMYHASKLSIDEEVYFENLMQLVEHYTTD----ADGLCTRLIKP-------------- 170 I K + F++L LVEHY + G +L +P Sbjct: 191 VMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESR 250 Query: 171 -----KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGE 205 K+ E T + F+ L +E KLL + +G+ Sbjct: 251 VRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQ 290 Score = 93.0 bits (230), Expect = 3e-19, Method: Composition-based stats. Identities = 41/139 (29%), Positives = 56/139 (40%), Gaps = 11/139 (7%) Query: 76 KLSLMPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH 134 ++ WFH IT +AE LL G FL R S + PGD+TL V G V H +I Sbjct: 21 GMTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNT 80 Query: 135 ASKLSIDEEVYFENLMQLVEHY------TTDADGLCTRLIKPKVMEGTVAAQDEFYRSGW 188 + F L +LV++Y + +G L P + E + G Sbjct: 81 GGYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTS---ERWFHGH 137 Query: 189 ALNMKELKLLQTIGK-GEF 206 + KLL GK G F Sbjct: 138 LSGKEAEKLLTEKGKHGSF 156 >1CSN-A nrPDB Length = 298 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 49/276 (17%), Positives = 95/276 (34%), Gaps = 29/276 (10%) Query: 195 LKLLQTIGKGEFGDVMLGDY--RGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLL 252 K+ + IG+G FG + G +VA+K + A E L + + Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNV 71 Query: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 +E +V + + SL D L GR + + + ++ + + V+ Sbjct: 72 YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGR-KFSVKTVAMAAKQMLARVQSIHEKSLVY 129 Query: 313 RDLAARNVLVSEDNV-----AKVSDFGLTKEASSTQDTGKLP----------VKWTAPEA 357 RD+ N L+ N V DFG+ K +P ++ + Sbjct: 130 RDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINT 189 Query: 358 LREKKFSTKSDVWSFG-ILLWEIYSFGRVPYPRI---PLKDVVPRV-EKGYKMDAPDGC- 411 ++ S + D+ + G + ++ + G +P+ + K R+ EK + C Sbjct: 190 HLGREQSRRDDLEALGHVFMY--FLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCA 247 Query: 412 --PPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 P Y M +L P + L+ + Sbjct: 248 GFPEEFYKYMHYARNLAFDATPDYDYLQGLFSKVLE 283 >5OAT-A nrPDB Length = 411 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 52/316 (16%), Positives = 104/316 (32%), Gaps = 79/316 (25%) Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKNDATAQAFLAEAS 238 + + +L L + I KG G V + ++ A+K + N + + Sbjct: 4 ESNPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILK 63 Query: 239 VM---------------------------TQLR-HSNLVQLLGVIVEEKG---------- 260 M L H N+V + V + Sbjct: 64 AMYRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPE 123 Query: 261 ------GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 L+++ + +L +L + + L + E + ++ + HRD Sbjct: 124 GEGRNMSLFLLMKRYD-CNLQSFLSTAPSTRTSLLLLAQLL----EGVAHMTAHGIAHRD 178 Query: 315 LAARNVLVS----EDNVAKVSDF---------GLTKEASSTQDTGKLPVKWTAPEALREK 361 L + N+L+ E + +SDF GL+ +S + APE + +K Sbjct: 179 LKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQK 238 Query: 362 K-------FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414 +S K+D+W+ G + +EI++ P+ ++G PD P Sbjct: 239 PGTFSVLNYS-KADLWAVGAIAYEIFNC-HNPFYGPSRLKNFN-YKEGDLPKLPDEVPTV 295 Query: 415 VYDVMKNCWHLDAATR 430 + ++ N + R Sbjct: 296 IQALVANLLKRNPNKR 311 >6EQI-C nrPDB Length = 433 Score = 111 bits (278), Expect = 7e-25, Method: Composition-based stats. Identities = 62/336 (18%), Positives = 113/336 (33%), Gaps = 85/336 (25%) Query: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCI------- 224 ++ E A N+ EL L + I KG V + +++AVK + Sbjct: 1 SESENVEQLQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVES 60 Query: 225 KNDATAQAFLAE---------------ASVMTQLR-----HSNLVQLLGVIVEEKGGL-- 262 + A +A E ++ + H N+V++ V + L Sbjct: 61 NSTAILKAMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQC 120 Query: 263 ------------------------YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 ++V + +L +YLR + ++ LL L Sbjct: 121 NKQLYPEALPPRINPEGSGRNMSLFLVMKRYD-CTLKEYLRDKTPNMRSSILLLSQLL-- 177 Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDN-----VAKVSDF---------GLTKEASSTQD 344 EA+ ++ +N HRDL + N+LV ++DF GL S Sbjct: 178 -EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQ 236 Query: 345 TGKLPVKWTAPEALREKKFS------TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 APE K + KSD+W+ G + +EI++ P+ +K + Sbjct: 237 DKGGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNI-DNPFYDKTMKLLSKS 295 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFL 434 ++ + PD P + +++ N R Sbjct: 296 YKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRLDCD 331 >5CLR-A nrPDB Length = 451 Score = 109 bits (272), Expect = 4e-24, Method: Composition-based stats. Identities = 43/224 (19%), Positives = 87/224 (38%), Gaps = 23/224 (10%) Query: 208 DVMLGDYRGNKVAVKCIKNDATA-QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGL-YIV 265 V G +K +K DA + F E +++L +L+G E+ + YI+ Sbjct: 97 KVY-ALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQVHYIL 150 Query: 266 TEYMAKGSLVDYLRSRGRSVLGGD-----CLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320 T ++ L Y + L + +L + VC ++ +HRDL N+ Sbjct: 151 TTFIKGIDLSRY---KNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNI 207 Query: 321 LVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKK---FSTKSDVWSFGILLW 377 ++ D + DFG + + + APE ++ FS SD+++ L Sbjct: 208 MLDADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSLD 267 Query: 378 EIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 E+++ P+ ++ V ++ + + + +M N Sbjct: 268 ELFN----PFRQVKFAKVDIGIKNKHLVLLHAEIEACITGLMSN 307 >4XZ1-A nrPDB Length = 262 Score = 106 bits (266), Expect = 2e-23, Method: Composition-based stats. Identities = 44/132 (33%), Positives = 59/132 (44%), Gaps = 6/132 (4%) Query: 48 YKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYP--PETGLFL 105 +K + + + II + + E + A T MPW+H +TRE+AER LY G FL Sbjct: 134 WKLEGEALEQAII--SQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFL 191 Query: 106 VRESTNYPGDYTLCVSCEGKVEHYRIMYH-ASKLSIDEEVYFENLMQLVEHYTTDADGLC 164 +R G Y L + V HY I A K I E F+ L QLVE+ ADGL Sbjct: 192 LRPRKEQ-GTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLI 250 Query: 165 TRLIKPKVMEGT 176 L + Sbjct: 251 YCLKEACPNSSA 262 Score = 73.0 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 31/109 (28%), Positives = 46/109 (42%), Gaps = 3/109 (2%) Query: 81 PWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH-ASK 137 P+F+G I+R +AE L GLFL+R+ G Y L + + + H+ I Sbjct: 12 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGT 71 Query: 138 LSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRS 186 +I +L E Y+ D DGL L KP + Q + S Sbjct: 72 YAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDS 120 >2B3O-A nrPDB Length = 532 Score = 105 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 53/233 (22%), Positives = 85/233 (36%), Gaps = 48/233 (20%) Query: 21 HGTAEQDLPFCKGDVLTIVAVTKDPNWYK-------AKNKVGREGIIPANYV-QKREGVK 72 + L GD +T + + ++Y A E V Q R+G Sbjct: 34 KNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTI 93 Query: 73 AGTKL-------SLMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCEG 124 K + W+HG ++ QAE LL FLVRES + PGD+ L V + Sbjct: 94 IHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQ 153 Query: 125 ---------KVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTT----DADGLCTRLIKP- 170 +V H ++M + ++ F++L LVEH+ +A G L +P Sbjct: 154 PKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPY 213 Query: 171 ------------------KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGE 205 K E A+ F+ +L +E+K L +G+ Sbjct: 214 YATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQ 266 Score = 91.1 bits (225), Expect = 8e-19, Method: Composition-based stats. Identities = 32/109 (29%), Positives = 44/109 (40%), Gaps = 7/109 (6%) Query: 79 LMPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASK 137 ++ WFH ++ AE LL G FL R S GD++L V +V H RI Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 Query: 138 LSIDEEVYFENLMQLVEHYT------TDADGLCTRLIKPKVMEGTVAAQ 180 + F L +LVE+YT D DG L P + + Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSER 109 >3PS5-A nrPDB Length = 595 Score = 104 bits (261), Expect = 6e-23, Method: Composition-based stats. Identities = 53/233 (22%), Positives = 85/233 (36%), Gaps = 48/233 (20%) Query: 21 HGTAEQDLPFCKGDVLTIVAVTKDPNWYK-------AKNKVGREGIIPANYV-QKREGVK 72 + L GD +T + + ++Y A E V Q R+G Sbjct: 34 KNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTI 93 Query: 73 AGTKL-------SLMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCEG 124 K + W+HG ++ QAE LL FLVRES + PGD+ L V + Sbjct: 94 IHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQ 153 Query: 125 ---------KVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTT----DADGLCTRLIKP- 170 +V H ++M + ++ F++L LVEH+ +A G L +P Sbjct: 154 PKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPY 213 Query: 171 ------------------KVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGE 205 K E A+ F+ +L +E+K L +G+ Sbjct: 214 YATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQ 266 Score = 90.7 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 32/109 (29%), Positives = 44/109 (40%), Gaps = 7/109 (6%) Query: 79 LMPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASK 137 ++ WFH ++ AE LL G FL R S GD++L V +V H RI Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 Query: 138 LSIDEEVYFENLMQLVEHYT------TDADGLCTRLIKPKVMEGTVAAQ 180 + F L +LVE+YT D DG L P + + Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSER 109 >5M6U-B nrPDB Length = 724 Score = 103 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 2/120 (1%) Query: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRE-STNYPGDYTLCVSCEGKVE 127 G+ L W+ G I+RE+ L G FLVR+ ST GDYTL + G + Sbjct: 320 NGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNK 379 Query: 128 HYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPK-VMEGTVAAQDEFYRS 186 +I + K + + F ++++L+ HY ++ + K + + QD+ + Sbjct: 380 LIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKE 439 Score = 73.8 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 28/85 (32%), Positives = 38/85 (44%), Gaps = 2/85 (2%) Query: 77 LSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS 136 W G R +AE LL G FLVRES+ G Y V +G+V+H I A+ Sbjct: 619 HDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQ-GCYACSVVVDGEVKHCVINKTAT 677 Query: 137 KLSIDEEVY-FENLMQLVEHYTTDA 160 E + +L +LV HY + Sbjct: 678 GYGFAEPYNLYSSLKELVLHYQHTS 702 Score = 36.8 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 27/73 (36%), Gaps = 15/73 (20%) Query: 9 PSGTECIAKYNFHGTAEQDLPFCKGDVLTIVA--------------VTKDPNWYKAKNK- 53 G + A Y++ E+D+ GD+LT+ ++ W N+ Sbjct: 3 AEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNET 62 Query: 54 VGREGIIPANYVQ 66 G G P YV+ Sbjct: 63 TGERGDFPGTYVE 75 >1RPY-A nrPDB Length = 114 Score = 103 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 26/93 (27%), Positives = 50/93 (53%), Gaps = 3/93 (3%) Query: 70 GVKAGTKLSLMPWFHGKITREQAERLLYPPE---TGLFLVRESTNYPGDYTLCVSCEGKV 126 G +LS PWFHG ++R +A +L+ GLF++R+S PG+ L + +GK Sbjct: 1 GSHMELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKA 60 Query: 127 EHYRIMYHASKLSIDEEVYFENLMQLVEHYTTD 159 +H R+ + + ++F+++ ++ H+ T Sbjct: 61 KHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTH 93 >2EKX-A nrPDB Length = 110 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 34/111 (30%), Positives = 58/111 (52%), Gaps = 9/111 (8%) Query: 70 GVKAGTKLSLMPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCE----- 123 G + L WF G I+R Q+E+LL G F+VR S + G YT+ + + Sbjct: 1 GSSGSSGLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDK 59 Query: 124 -GKVEHYRIMYHA-SKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKV 172 G V+HY + +A +KL + E F+++ +L+ ++ ++ G+ TRL P Sbjct: 60 KGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVS 110 >2EOB-A nrPDB Length = 124 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 31/107 (28%), Positives = 48/107 (44%), Gaps = 2/107 (1%) Query: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYP-PETGLFLVRESTNYPGDYTLCVSCEGKVE 127 + V PW++ +++R +AE +L P G FL+R+ Y + GKV+ Sbjct: 8 DPVPNPNPHESKPWYYDRLSRGEAEDMLMRIPRDGAFLIRKREGTD-SYAITFRARGKVK 66 Query: 128 HYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVME 174 H RI + YFE+L++LV +Y A RL P E Sbjct: 67 HCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPE 113 >2LQW-A nrPDB Length = 303 Score = 102 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 28/96 (29%), Positives = 45/96 (46%) Query: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSID 141 W+ G ++R++A+ L G+FLVR+S+ PGDY L VS +V HY I ++ Sbjct: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73 Query: 142 EEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTV 177 + F++L L+E Y T + Sbjct: 74 GDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPP 109 Score = 78.4 bits (192), Expect = 6e-15, Method: Composition-based stats. Identities = 24/64 (37%), Positives = 35/64 (54%), Gaps = 1/64 (1%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 Y+F G +DLPF KG++L I+ ++ W+ A+NK GR G+IP YV+K Sbjct: 128 VRTLYDFPGNDAEDLPFKKGEILVIIEKPEE-QWWSARNKDGRVGMIPVPYVEKLVRSSP 186 Query: 74 GTKL 77 K Sbjct: 187 HGKH 190 Score = 31.0 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 22/48 (45%), Gaps = 2/48 (4%) Query: 22 GTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKRE 69 + L GD++ + + + W + + GR+G+ P +V+ + Sbjct: 250 AYDKTALALEVGDIVKVTRMNINGQW-EGEV-NGRKGLFPFTHVKIFD 295 >2HDV-A nrPDB Length = 111 Score = 101 bits (253), Expect = 5e-22, Method: Composition-based stats. Identities = 26/86 (30%), Positives = 49/86 (56%), Gaps = 3/86 (3%) Query: 77 LSLMPWFHGKITREQAERLLYPPE---TGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY 133 LS PWFHG ++R +A +L+ G+FLVR+S G+ L + +GK +H R+ Sbjct: 6 LSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHLRLSL 65 Query: 134 HASKLSIDEEVYFENLMQLVEHYTTD 159 +A+ + ++F+++ ++EH+ Sbjct: 66 NAAGQCRVQHLHFQSIFDMLEHFRVH 91 >2VIF-A nrPDB Length = 141 Score = 100 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 3/120 (2%) Query: 65 VQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEG 124 + + KL+ W+ G ITR +AE L G FLVR+S++ +L G Sbjct: 9 MDVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHG 68 Query: 125 KVEHYRIMYHASKLSIDEEVYFE---NLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQD 181 K H RI + + S E+ E +++ L+EH D++ + ++ Sbjct: 69 KTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIGDSENGAFCYSRSRLPGSATYPVR 128 >5U06-A nrPDB Length = 120 Score = 100 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 34/103 (33%), Positives = 50/103 (48%), Gaps = 7/103 (6%) Query: 77 LSLMPWFHGKITREQAERLLYPPE--TGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH 134 WFHG+I+RE+++RL+ GLFLVRES P + L + KV+HY I+ Sbjct: 14 HRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPS 73 Query: 135 --ASKLSI---DEEVYFENLMQLVEHYTTDADGLCTRLIKPKV 172 +L D + F +L+QLVE + + L L Sbjct: 74 EEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCT 116 >2CRH-A nrPDB Length = 138 Score = 99 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 26/94 (27%), Positives = 44/94 (46%) Query: 77 LSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS 136 LS+ W+ G + R AE +L G FLVR+ ++ + + +V+H +IM Sbjct: 23 LSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEG 82 Query: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 I E+ F L +LVE Y ++ C + + Sbjct: 83 LYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDT 116 >2AUG-A nrPDB Length = 126 Score = 99.2 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 7/107 (6%) Query: 73 AGTKLSLMPWFHGKITREQAERLLYPPE--TGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 + PWFH KI+R++A+RL+ G+FLVR+S + P + L +S K++H++ Sbjct: 19 SHMIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQ 78 Query: 131 IMY--HASKLSI---DEEVYFENLMQLVEHYTTDADGLCTRLIKPKV 172 I+ ++ D F +L+QLVE Y + L +L Sbjct: 79 IIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCA 125 >2LCT-A nrPDB Length = 107 Score = 98.4 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 26/94 (27%), Positives = 44/94 (46%) Query: 77 LSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS 136 LS+ W+ G + R AE +L G FLVR+ ++ + + +V+H +IM Sbjct: 6 LSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEG 65 Query: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 I E+ F L +LVE Y ++ C + + Sbjct: 66 LYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDT 99 >2KK6-A nrPDB Length = 116 Score = 96.9 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 32/87 (36%), Positives = 46/87 (52%), Gaps = 3/87 (3%) Query: 77 LSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS 136 L+ W+HG I R +A+ LL G FLVRES PG+Y L V +G+ H+ I Y Sbjct: 14 LAEQDWYHGAIPRIEAQELLKKQ--GDFLVRESHGKPGEYVLSVYSDGQRRHFIIQY-VD 70 Query: 137 KLSIDEEVYFENLMQLVEHYTTDADGL 163 + E F N+ QL++H+ T + Sbjct: 71 NMYRFEGTGFSNIPQLIDHHYTTKQVI 97 >1KA6-A nrPDB Length = 128 Score = 96.5 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 7/107 (6%) Query: 83 FHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCEGKVEHYRI------MYHA 135 +HGKI+RE E+LL G +L+R+S + PG Y LCV G + YR+ + A Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSA 66 Query: 136 SKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDE 182 + YF + L+ + G+ L P + + + Sbjct: 67 ETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQG 113 >2PLE-A nrPDB Length = 105 Score = 95.3 bits (236), Expect = 5e-20, Method: Composition-based stats. Identities = 29/102 (28%), Positives = 46/102 (45%), Gaps = 3/102 (2%) Query: 77 LSLMPWFHGKITREQAERLLYP-PETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHA 135 W+H +TR QAE +L P G FLVR+ N P Y + EGK++H R+ Sbjct: 6 HESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKR-NEPNSYAISFRAEGKIKHCRVQQEG 64 Query: 136 SKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTV 177 + + F++L+ L+ +Y +L P E + Sbjct: 65 QTVML-GNSEFDSLVDLISYYEKHPLYRKMKLRYPINEENSS 105 >1M27-A nrPDB Length = 104 Score = 91.5 bits (226), Expect = 7e-19, Method: Composition-based stats. Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 7/96 (7%) Query: 83 FHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCEGKVEHYRI------MYHA 135 +HGKI+RE E+LL G +L+R+S + PG Y LCV G + YR+ + A Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSA 66 Query: 136 SKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPK 171 + YF + L+ + G+ L P Sbjct: 67 ETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPV 102 >1NRV-A nrPDB Length = 105 Score = 91.1 bits (225), Expect = 8e-19, Method: Composition-based stats. Identities = 27/103 (26%), Positives = 50/103 (48%), Gaps = 7/103 (6%) Query: 77 LSLMPWFHGKITREQAERLLYPPE--TGLFLVRESTNYPGDYTLCVSCEGKVEHYRI--M 132 WFHG+I+RE++ R++ GLFL+R+S + P + L + K+++++I Sbjct: 2 HRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPC 61 Query: 133 YHASKLSI---DEEVYFENLMQLVEHYTTDADGLCTRLIKPKV 172 + D F +L+QLV+ Y + L +L + Sbjct: 62 EDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCI 104 >5GZ9-A nrPDB Length = 305 Score = 91.1 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 107/285 (37%), Gaps = 59/285 (20%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQL 251 E++ L+ +G+G V L +++ +KVA+ + + FL ++ L+ ++V L Sbjct: 33 RTEVRQLKRVGEGAVKRVFLSEWKEHKVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTL 92 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 +G E+ I+TEY GSL + + S + L + AMEY+ N++ Sbjct: 93 VGYCEEDGT---ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQL--AMEYVSIINYL 147 Query: 312 HRDLAARNVLVSEDNVAK-VSDFGLTKEAS-STQDTGKLPV------------------K 351 H V+ +++ K +S + LT S D LP+ Sbjct: 148 HHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGD 207 Query: 352 WTAPEAL------------REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV 399 + APE L ++ K D+W ++P + + Sbjct: 208 FVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW-------------KIP----DVSSFLLGH 250 Query: 400 EKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 +G M ++D+ K C A RPT + + + + Sbjct: 251 VEGSDMVRF-----HLFDIHKACKSQIPAERPTAQNVLDAYQRVF 290 >2EYZ-A nrPDB Length = 304 Score = 90.7 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 35/113 (30%), Positives = 52/113 (46%), Gaps = 20/113 (17%) Query: 78 SLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY---- 133 W+ G+++R++A LL G+FLVR+S+ PGDY L VS +V HY I Sbjct: 9 ERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPR 68 Query: 134 --------------HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKV 172 S+L I ++ F++L L+E Y T LI+P Sbjct: 69 PPVPPSPAQPPPGVSPSRLRIGDQE-FDSLPALLEFYKIHYLDT-TTLIEPVS 119 Score = 74.9 bits (183), Expect = 6e-14, Method: Composition-based stats. Identities = 23/63 (36%), Positives = 36/63 (57%), Gaps = 1/63 (1%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 A ++F+G E+DLPF KGD+L I ++ W+ A++ G+ G+IP YV+K A Sbjct: 137 VRALFDFNGNDEEDLPFKKGDILRIRDKPEE-QWWNAEDSEGKRGMIPVPYVEKYRPASA 195 Query: 74 GTK 76 Sbjct: 196 SVS 198 >4JRN-A nrPDB Length = 372 Score = 90.7 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 87/272 (31%), Gaps = 50/272 (18%) Query: 200 TIGKGEFGDVMLGDY--RGNKVAVKCI-----KNDATAQAFLAEASVMTQLRH------- 245 +G G F V ++AVK D T E+S Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 246 ---------SNLVQLLGVIVEEKGGLYIVTEYMAK---------GSLVDYLR------SR 281 S++V L G + + + T ++ + + S Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 282 GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS 341 +S G + S + + ++ VH D+ N L+ +D + DFG + ++ Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYR-INN 253 Query: 342 TQDTGKLPVKWTAPE---ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398 + + PE ++ +D W GI L+ I+ P P + D + Sbjct: 254 SVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCK-ERPTPADGIWDYLHF 312 Query: 399 VEKGYKMDAPDGCPPAVYDVMKNCWHLDAATR 430 D P P V D++++ + D R Sbjct: 313 A------DCPS-TPELVQDLIRSLLNRDPQKR 337 >1MIL-A nrPDB Length = 104 Score = 88.0 bits (217), Expect = 8e-18, Method: Composition-based stats. Identities = 30/102 (29%), Positives = 53/102 (51%), Gaps = 3/102 (2%) Query: 74 GTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMY 133 G++L PWFHGK++R +AE LL G FLVREST PG Y L G+ +H ++ Sbjct: 1 GSQLRGEPWFHGKLSRREAEALL--QLNGDFLVRESTTTPGQYVLTGLQSGQPKHL-LLV 57 Query: 134 HASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEG 175 + ++ FE++ L+ ++ + + + + + + Sbjct: 58 DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQP 99 >3CXL-A nrPDB Length = 463 Score = 87.2 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 33/92 (35%), Positives = 46/92 (50%), Gaps = 9/92 (9%) Query: 83 FHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDE 142 FHG I+RE A++LL G +L+RES PG YTL + + ++R+ Y Sbjct: 54 FHGMISREAADQLLI-VAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHF--VG 110 Query: 143 EVYFENLMQLVEHYTTDADGLCTRLIKPKVME 174 E FE++ LV DGL T I+ K E Sbjct: 111 EKRFESIHDLV------TDGLITLYIETKAAE 136 >5GZA-A nrPDB Length = 290 Score = 86.1 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 103/277 (37%), Gaps = 44/277 (15%) Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQL 251 ++ ++ IG+G V L +++G KVA+ + +D A FL S++ L+ S++V L Sbjct: 24 RSGVRRVKLIGQGAVKKVYLSEWQGQKVALSVLSSDQYADDFLHGLSMLRALQSSHVVTL 83 Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 +GV E+ VTEY GS++ + + L + A++Y+ ++ Sbjct: 84 VGVCEEDA---VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQL--AIDYVAFLAYL 138 Query: 312 HRDLAARNVLVSEDNVAK-VSDFGLTKEASSTQD------------------TGKLPVKW 352 H A V+ +++ K +S F L + + +L + Sbjct: 139 HSSPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDF 198 Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 APE L W +G E +SF P K + ++ + D Sbjct: 199 VAPEQL-----------WPYG----EDFSFSDEAMPGYDEKTDIWKIPDVTRFLLGDVLG 243 Query: 413 PAVYDVM-----KNCWHLDAATRPTFLQLREQLEHIR 444 V C +A RPT ++ + Sbjct: 244 GDVIHFHLFQIYSECKRKEAHMRPTAREVLSVYRSVY 280 >1XA6-A nrPDB Length = 466 Score = 85.3 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 34/92 (36%), Positives = 47/92 (51%), Gaps = 9/92 (9%) Query: 83 FHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDE 142 FHG I+REQA+ LL E G +++RES PG YTL + + +YR+ + Sbjct: 58 FHGIISREQADELLGGVE-GAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHF--VG 114 Query: 143 EVYFENLMQLVEHYTTDADGLCTRLIKPKVME 174 E FE++ LV DGL T I+ K E Sbjct: 115 EKRFESIHDLV------TDGLITLYIETKAAE 140 >2CS0-A nrPDB Length = 119 Score = 82.2 bits (202), Expect = 4e-16, Method: Composition-based stats. Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 4/99 (4%) Query: 81 PWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRI-MYHASKLS 139 WFHG I+RE AE LL G FL+R S ++ G YTL + H+ + + Sbjct: 17 EWFHGAISREDAENLLESQPLGSFLIRVSHSHVG-YTLSYKAQSSCCHFMVKLLDDGTFM 75 Query: 140 I-DEEVYFENLMQLVEHY-TTDADGLCTRLIKPKVMEGT 176 I E+V +L LV + + L +P + + Sbjct: 76 IPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPCRQKDS 114 >5NP2-A nrPDB Length = 61 Score = 78.4 bits (192), Expect = 6e-15, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 29/56 (51%), Gaps = 1/56 (1%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKRE 69 +A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ Sbjct: 7 FVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITPVN 61 >2RSV-A nrPDB Length = 403 Score = 77.6 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 47/266 (17%), Positives = 101/266 (37%), Gaps = 47/266 (17%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKND--------------ATAQ 231 KE K+ IG+G FG + L D ++ VK +D A + Sbjct: 42 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 101 Query: 232 AFLAEASVMTQLRHSNLVQLLGVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 +L++ + + G + +K +++ + GS + + Sbjct: 102 QIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSR 158 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS--EDNVAKVSDFGLT---------- 336 +L+ SL + + +EY+ + +VH D+ A N+L++ + + D+GL Sbjct: 159 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 218 Query: 337 KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396 + + +++T+ +A S + D+ G + + + G +P+ LKD Sbjct: 219 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED-NLKD-- 274 Query: 397 PRVEKGYKMDAPDGCPPAVYDVMKNC 422 P+ + K+ + +M C Sbjct: 275 PKYVRDSKIR----YRENIASLMDKC 296 >1GBQ-A nrPDB Length = 74 Score = 77.2 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 25/60 (41%), Positives = 39/60 (65%), Gaps = 1/60 (1%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72 E IAKY+F TA+ +L F +GD+L ++ D NWYKA+ G++G IP NY++ + + Sbjct: 11 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAEL-NGKDGFIPKNYIEMKPHPE 69 >2LAV-A nrPDB Length = 361 Score = 76.8 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 47/266 (17%), Positives = 101/266 (37%), Gaps = 47/266 (17%) Query: 193 KELKLLQTIGKGEFGDVMLGDYRGNK-------VAVKCIKND--------------ATAQ 231 KE K+ IG+G FG + L D ++ VK +D A + Sbjct: 35 KEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPE 94 Query: 232 AFLAEASVMTQLRHSNLVQLLGVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 +L++ + + G + +K +++ + GS + + Sbjct: 95 QIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKRFSR 151 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS--EDNVAKVSDFGLT---------- 336 +L+ SL + + +EY+ + +VH D+ A N+L++ + + D+GL Sbjct: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 Query: 337 KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396 + + +++T+ +A S + D+ G + + + G +P+ LKD Sbjct: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED-NLKD-- 267 Query: 397 PRVEKGYKMDAPDGCPPAVYDVMKNC 422 P+ + K+ + +M C Sbjct: 268 PKYVRDSKIR----YRENIASLMDKC 289 >4O1O-A nrPDB Length = 717 Score = 76.1 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 41/232 (17%), Positives = 86/232 (37%), Gaps = 37/232 (15%) Query: 207 GDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLR-HSNLVQLLGVIVEEKGGLYIV 265 G + LG Y +VAVK +T E S + R + N+V G + L++ Sbjct: 360 GGIYLGLYEDQEVAVKRFSEGSTRGQ--QEVSCLQSSRANDNVVTFYGS-ESDGSCLHVC 416 Query: 266 TEYMAKGSLVDYLRSRGRSVLGGDC---LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV 322 +L ++L + + + + +A+ L + + H+DL +N+L+ Sbjct: 417 LALCEY-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILI 475 Query: 323 SEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSF 382 N ++DF +KW E K D+ + G+L+ + Sbjct: 476 DSKNGTFLADF-------------DKSIKW------AEDPQKIKRDLEALGLLVLYVVKK 516 Query: 383 GRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHL--DAATRPT 432 G + + + + ++ +PD D++ + +H + R + Sbjct: 517 GDISFETLKNQSFEEVIQG-----SPD---EETRDLIHHLFHPGDNVEDRLS 560 >2CT4-A nrPDB Length = 70 Score = 75.7 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 18/61 (29%), Positives = 35/61 (57%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 C+A Y+F G++E + +G+ L+++ K W + + K G EG +P +Y++ G + Sbjct: 10 CVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTSGPSS 69 Query: 74 G 74 G Sbjct: 70 G 70 >5UU1-A nrPDB Length = 324 Score = 75.3 bits (184), Expect = 5e-14, Method: Composition-based stats. Identities = 38/233 (16%), Positives = 87/233 (37%), Gaps = 37/233 (15%) Query: 190 LNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIKNDATAQ-AFLAEASVMTQLRHS 246 + + L + IG G FG + L + K A +K + +E ++ Sbjct: 13 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK 72 Query: 247 NLVQ---------------LLGVI---VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 + ++ G + + ++V E + L S Sbjct: 73 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKI--SGQNGTFKK 129 Query: 289 DCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV--SEDNVAKVSDFGLT---------- 336 +L+ + + + +EY+ N +VH D+ A N+L+ + ++D+GL+ Sbjct: 130 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHK 189 Query: 337 KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR 389 + + + +++T+ +A + S +SDV G + G++P+ + Sbjct: 190 QYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLC-GKLPWEQ 241 >6EWX-A nrPDB Length = 484 Score = 75.3 bits (184), Expect = 6e-14, Method: Composition-based stats. Identities = 38/234 (16%), Positives = 79/234 (33%), Gaps = 51/234 (21%) Query: 257 EEKGGLYIVTEYMAKGSLVDYLR-----SRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 +E+ + ++T + + D++R R + + L +C +E+L+ + + Sbjct: 173 QEQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGII 232 Query: 312 HRDLAARNVLV---------------------------------------SEDNVAK--V 330 HRDL N+L+ E ++ + + Sbjct: 233 HRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLII 292 Query: 331 SDFGLTKEASSTQDT--GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388 S+F K+ K APE + ++ K D + GIL++E+ P+ Sbjct: 293 SNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY-RKFDEFQTGILIYELL-HQPNPFE 350 Query: 389 -RIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 R L++ R E + P + + D R + + L+ Sbjct: 351 VRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQ 404 >4IX6-A nrPDB Length = 350 Score = 74.9 bits (183), Expect = 7e-14, Method: Composition-based stats. Identities = 52/254 (20%), Positives = 93/254 (36%), Gaps = 65/254 (25%) Query: 190 LNMKELKLL-QTIGKGEFGDVMLGDYRGNK-VAVKCIKNDATAQAFLAEASVMTQLR-HS 246 + K++++L +G G FG V G ++G++ V +K K D A L E + H+ Sbjct: 16 VEPKDIRVLPGPLGSGNFGTVFRGVFKGDQDVVLKNAKADVMAAEELLECEMDVNYHVHA 75 Query: 247 N----LVQLLGVIV---EEKGGLY--IVTE---YM---AKGSLVDYLRSRGRSVLGGDCL 291 N + +G I ++ G +Y +TE M + V+ L RG + L Sbjct: 76 NAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMA 135 Query: 292 ----------LKFSLDVCEAMEYLEGNNFVHRDLAARNVLV---SEDNVAKVSDFG---- 334 K ++ ++ L VHRD+ N L+ + V K+ D G Sbjct: 136 CADATELGVTKKAMRELLGSLARLHECGVVHRDVKPAN-LIAAEKDGGVLKLIDLGAAAL 194 Query: 335 ---LTKEASSTQDTGKLPVKW--------TAP--------------EALREKKFSTKSDV 369 L + + G ++ P EA + +F + Sbjct: 195 CLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS---- 250 Query: 370 WSFGILLWEIYSFG 383 WS G ++ ++ G Sbjct: 251 WSAGCVMLQLAVVG 264 >3GF9-A nrPDB Length = 295 Score = 74.5 bits (182), Expect = 9e-14, Method: Composition-based stats. Identities = 18/66 (27%), Positives = 34/66 (51%), Gaps = 2/66 (3%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREG 70 G + IA Y++ E +L F KG ++ ++ DP+W++ + G G+ P+NYV+ Sbjct: 18 GCQVIAMYDYAANNEDELSFSKGQLINVMNK-DDPDWWQGEI-NGVTGLFPSNYVKMTTD 75 Query: 71 VKAGTK 76 + Sbjct: 76 SDPSQQ 81 >2DLM-A nrPDB Length = 68 Score = 74.5 bits (182), Expect = 9e-14, Method: Composition-based stats. Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 2/69 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYV 65 +S SG K++F + ++L KGD++ I D NW + ++ GR GI PANYV Sbjct: 2 SSGSSGKAARLKFDFQAQSPKELTLQKGDIVYIHKEV-DKNWLEGEHH-GRLGIFPANYV 59 Query: 66 QKREGVKAG 74 + G +G Sbjct: 60 EVLSGPSSG 68 >2JII-A nrPDB Length = 352 Score = 73.8 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 36/216 (16%), Positives = 84/216 (38%), Gaps = 24/216 (11%) Query: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 +G V + ++V + SL L + VL +L+ + + +A+E+L N +V Sbjct: 123 MGFGVHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 181 Query: 312 HRDLAARNVLVS--EDNVAKVSDFGLT----------KEASSTQDTGKLPVKWTAPEALR 359 H ++ A N+ V + + ++ +G ++ + +++ + + + Sbjct: 182 HGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHK 241 Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRI--PLKDVVPRVEKGYKMDAPD-------- 409 S +SD+ S G + + +G +P+ +D++ + +K P Sbjct: 242 GCGPSRRSDLQSLGYCMLKWL-YGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWI 300 Query: 410 GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445 + +K L +P + LR LE + Sbjct: 301 RPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQ 336 >5VEI-A nrPDB Length = 110 Score = 72.2 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 2/63 (3%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 A Y+F ++L F KGD + I+ D NWY+ ++ GR GI P +YV+K G A Sbjct: 37 AKAVYDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHH-GRVGIFPISYVEKLTGSAA 94 Query: 74 GTK 76 + Sbjct: 95 ALR 97 >2BBU-A nrPDB Length = 164 Score = 70.7 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 25/119 (21%), Positives = 45/119 (37%), Gaps = 9/119 (7%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 V A KL ++ +T +A LL G FL+R+S++ +TL V + ++ R Sbjct: 14 VNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLR 73 Query: 131 IMYHASKLSIDEE-------VYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDE 182 I S+ + F+ +++LV HY P + + Sbjct: 74 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPG--TPSFSLPPTEPSSEVPEQP 130 >5DMZ-A nrPDB Length = 365 Score = 70.7 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 45/308 (14%), Positives = 108/308 (35%), Gaps = 36/308 (11%) Query: 169 KPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLG------DYRGNKVAVK 222 P E ++ + L K + + +G+G F V D + + V Sbjct: 41 YPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVL 100 Query: 223 CIKNDATAQAFLAEASVMTQL----RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL 278 ++ A F +M +L +H ++ + + G + +V E + G+L++ + Sbjct: 101 KVQKPANPWEFYIGTQLMERLKPSMQHM-FMKFYSAHLFQNGSV-LVGELYSYGTLLNAI 158 Query: 279 ---RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNV-------- 327 ++ V+ ++ F++ + +E + +H D+ N ++ + Sbjct: 159 NLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDL 218 Query: 328 ---AKVSDFGLTKEASSTQDTGKLPVK-----WTAPEALREKKFSTKSDVWSFGILLWEI 379 + D G + + K + E L K ++ + D + ++ + Sbjct: 219 SAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCM 278 Query: 380 YSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 FG Y ++ + + E ++ + VM N D P+ LR++ Sbjct: 279 L-FGT--YMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNI--PDCHHLPSLDLLRQK 333 Query: 440 LEHIRTHE 447 L+ + Sbjct: 334 LKKVFQQH 341 >2HMH-A nrPDB Length = 152 Score = 70.3 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 24/98 (24%), Positives = 42/98 (42%), Gaps = 7/98 (7%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 V A KL ++ +T +A LL G FL+R+S++ +TL V + ++ R Sbjct: 25 VNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLR 84 Query: 131 IMYHASKLSIDEE-------VYFENLMQLVEHYTTDAD 161 I S+ + F+ +++LV HY Sbjct: 85 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPQA 122 >4GL9-E nrPDB Length = 143 Score = 69.9 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 7/93 (7%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 V A KL ++ +T +A LL G FL+R+S++ +TL V + ++ R Sbjct: 19 VNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLR 78 Query: 131 IMYHASKLSIDEE-------VYFENLMQLVEHY 156 I S+ + F+ +++LV HY Sbjct: 79 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 111 >4OAU-C nrPDB Length = 699 Score = 69.5 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 29/131 (22%), Positives = 53/131 (40%), Gaps = 7/131 (5%) Query: 207 GDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLR-HSNLVQLLGVIVEEKGGLYIV 265 G + LG Y +VAVK + E S + R +S+LV G +G L++ Sbjct: 357 GGIYLGFYEKQEVAVKTF--CEGSPRAQREVSCLQSSRENSHLVTFYGS-ESHRGHLFVC 413 Query: 266 TEYMAKG--SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE-GNNFVHRDLAARNVLV 322 + + +D R + + +A++ L + H+DL +N+L+ Sbjct: 414 VTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI 473 Query: 323 SEDNVAKVSDF 333 A ++DF Sbjct: 474 DSKKAAHLADF 484 >2YUP-A nrPDB Length = 90 Score = 69.1 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 12/77 (15%) Query: 6 ASWPSGT----------ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAK-NKV 54 +S SG E +A+Y F G E +L F KG+ + ++ + NWY+ + Sbjct: 2 SSGSSGKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNE-NWYEGRITGT 60 Query: 55 GREGIIPANYVQKREGV 71 GR+GI PA+YVQ Sbjct: 61 GRQGIFPASYVQVSREP 77 >6BHC-A nrPDB Length = 438 Score = 68.7 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 48/270 (17%), Positives = 95/270 (35%), Gaps = 47/270 (17%) Query: 217 NKVAVKCIKND-ATAQAFLAEASVMTQLR-HSNLVQLLGVIV---------------EEK 259 N AVK K+ +Q + +V L H N+ Q G + +++ Sbjct: 84 NNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQR 143 Query: 260 GGLYIVTEYMAKGSLVDYLR----SRGRSV-LGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 + ++T + ++ D++R G+S L + L +C +E+L+ + H D Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCD 203 Query: 315 LAARNVLVSE---DNVAK------------------VSDFGLTKEASSTQDTGKLPVKWT 353 L N+L+ A+ VS+F K+ S D L + Sbjct: 204 LRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR 263 Query: 354 -APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY-KMDAPDGC 411 APE + ++ K D + GIL++E+ P+ P ++ Sbjct: 264 LAPEIITATQY-KKCDEFQTGILIYEMLHL-PNPFDENPELKEREYTRADLPRIPFRSPY 321 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 + + + + + R + L+ Sbjct: 322 SRGLQQLASCLLNPNPSERILISDAKGILQ 351 >3JV3-A nrPDB Length = 283 Score = 68.4 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 16/65 (24%), Positives = 35/65 (53%), Gaps = 2/65 (3%) Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71 + I Y++ + +L F KG ++ ++ +DP+W+K + G+ G+ P+NYV+ + Sbjct: 3 CQVIGMYDYTAQNDDELAFSKGQIINVLNK-EDPDWWKGEVS-GQVGLFPSNYVKLTTDM 60 Query: 72 KAGTK 76 + Sbjct: 61 DPSQQ 65 >4CI6-B nrPDB Length = 643 Score = 68.4 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 94/289 (32%), Gaps = 48/289 (16%) Query: 194 ELKLLQTIGKGEFGD------VMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL---- 243 +L+ ++ +F + ++ + VA I+ AE + Sbjct: 41 DLEGMRVAETDKFAEGESHISIIETKDKQRLVA--KIERSIAEGHLFAELEAYKHIYKTA 98 Query: 244 -RHSNLVQLLGVIVEEKGGLY---IVTEYMAK----GSLVDYLRSRGRSVLG----GDCL 291 +H NL + G+ V G Y ++ + + +L S + + + Sbjct: 99 GKHPNLANVHGMAVVPYGNRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTI 158 Query: 292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE-DNVAKVSDFGLTKEASSTQDTGKLPV 350 + + + +L VH D+ NV+ V D GL + S + Sbjct: 159 KFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL--HSRSGEQPKGFTE 216 Query: 351 KWTAPEA-LREKKFSTKSDVWSFGILLWEIYSFGRVPY---PRIPLKDVVPRV------- 399 + APE + S KSDV+ L+ G + P I + + Sbjct: 217 SFKAPELGVGNLGASEKSDVF----LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHV 272 Query: 400 --EKGYKMDAP--DGCPPAVYDVMKNCWHLDAATRPTFLQ--LREQLEH 442 E GY + P G A + + + A +RP + L E L Sbjct: 273 MDENGYPIHRPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSD 321 >6G4J-A nrPDB Length = 315 Score = 68.0 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 23/138 (16%), Positives = 51/138 (36%), Gaps = 17/138 (12%) Query: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 L + +GKG G V L + VA+K + + +E +V+ + V + Sbjct: 28 YTLRKQLGKGANGIVYLAETSDGHVALKV---SDDSLSITSEVNVLKSFSKAQSVTMGPS 84 Query: 255 IVEEKGGL---------YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 + + EY+ L+ Y+ +G + + + + ++ L Sbjct: 85 FFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG-----AEWIPVLMIQLLSSLSVL 139 Query: 306 EGNNFVHRDLAARNVLVS 323 ++ DL N++V+ Sbjct: 140 HQQGWIFGDLKPDNLIVT 157 >3QWY-A nrPDB Length = 308 Score = 68.0 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 22/53 (41%), Positives = 35/53 (66%), Gaps = 1/53 (1%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 + + F G E DLPF +G+ L I++ T +W++A+N +G G++PANYVQ Sbjct: 150 VVGTFKFTGERETDLPFEQGERLEILSKTN-QDWWEARNALGTTGLVPANYVQ 201 Score = 63.4 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 28/118 (23%), Positives = 48/118 (40%), Gaps = 19/118 (16%) Query: 58 GIIPA-NYVQKREGVK--AGTKLSLMPW---FHGKITREQAERLLYPP--ETGLFLVRES 109 G++P +++ G + W + ++RE+A +LL P G FL+R+S Sbjct: 13 GLVPRGSHMASMTGGQQMTTNGFDPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDS 72 Query: 110 TNYPGDYTLCVS---CEGKVEHYRIMYHASKL-------SIDEEVYFENLMQLVEHYT 157 + PG+Y+L V V HY I K F ++ L+ H+ Sbjct: 73 -SRPGEYSLTVREADEGNAVCHYLIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFK 129 >6C7Y-B nrPDB Length = 117 Score = 68.0 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 27/99 (27%), Positives = 44/99 (44%), Gaps = 2/99 (2%) Query: 73 AGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIM 132 A + L ++ G +T A L G FL+R+ST + + V RI Sbjct: 19 ASSLLDACGFYWGPLTVSAAHEKLKSEPEGTFLIRDSTQKNCFFAISVKTATGPTSIRIN 78 Query: 133 YHASKLSIDE-EVYFENLMQLVEHY-TTDADGLCTRLIK 169 + + S+D + F+ L +L+EHY ++ L T L K Sbjct: 79 FQTGRFSLDGSKETFDCLFKLLEHYLSSPRKVLVTPLRK 117 >4JGH-A nrPDB Length = 173 Score = 67.6 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 26/123 (21%), Positives = 48/123 (39%), Gaps = 7/123 (5%) Query: 76 KLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHA 135 +L W+ G +T +A+ L G FL+R+S++ T+ V + RI Y Sbjct: 17 ELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQD 76 Query: 136 SKLSIDE-------EVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGW 188 K +D F++++ L+++Y T P+ + Y S Sbjct: 77 GKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAP 136 Query: 189 ALN 191 +L Sbjct: 137 SLQ 139 >3HAJ-A nrPDB Length = 486 Score = 67.6 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 2/63 (3%) Query: 9 PSGTECI--AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 SGTE A Y++ G +L F GD LT + + W K + G+ G+ PANYV+ Sbjct: 424 TSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVE 483 Query: 67 KRE 69 + Sbjct: 484 AIQ 486 >4BNE-A nrPDB Length = 457 Score = 67.6 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 18/56 (32%), Positives = 29/56 (51%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKRE 69 A Y++ G + +L F GD LT + + W K + G+ G+ PANYV+ + Sbjct: 402 VRALYDYEGQEQDELSFKAGDELTKMENEDEQGWCKGRLDNGQVGLYPANYVEPIQ 457 >6F55-A nrPDB Length = 67 Score = 65.7 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 18/58 (31%), Positives = 28/58 (48%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 G A Y++ G +L F G+ L ++ + W K + G G+ PANYV+K Sbjct: 5 GVRVRALYDYTGQEADELSFKAGEELMKISEEDEQGWCKGRLLTGHVGLYPANYVEKV 62 >2X3W-D nrPDB Length = 60 Score = 65.7 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 18/56 (32%), Positives = 29/56 (51%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 G A Y++ G + +L F GD LT + + W + + G+ G+ PANYV+ Sbjct: 3 GVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 58 >2DA9-A nrPDB Length = 70 Score = 65.7 bits (159), Expect = 5e-11, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 35/70 (50%), Gaps = 2/70 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTK-DPNWYKAKNKVGREGIIPANY 64 +S SG C + + + +L +GD++T++ D W++ + GR G+ P N+ Sbjct: 2 SSGSSGDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGEL-NGRRGVFPDNF 60 Query: 65 VQKREGVKAG 74 V+ G +G Sbjct: 61 VKLLSGPSSG 70 >2KBT-A nrPDB Length = 142 Score = 64.5 bits (156), Expect = 9e-11, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 27/54 (50%), Gaps = 1/54 (1%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 A+Y+F +L +GD++ I+ W++ + GR G P+NYV+ Sbjct: 7 TAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEI-YGRIGWFPSNYVE 59 >6C5X-D nrPDB Length = 164 Score = 64.1 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 27/106 (25%), Positives = 43/106 (40%), Gaps = 1/106 (0%) Query: 71 VKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130 K + L ++ G + A L G FL+R+S + + V + R Sbjct: 21 TKTSSMLDTCGFYWGPMDVNVAHDKLKSEPIGTFLIRDSKQKNCFFAISVKTARETVSIR 80 Query: 131 IMYHASKLSIDE-EVYFENLMQLVEHYTTDADGLCTRLIKPKVMEG 175 I +HA K S+D + F L QLVEHY T + ++ + Sbjct: 81 IKFHAGKFSLDGSKELFSCLFQLVEHYMTSPKKMLVSPLRKVRLRP 126 >2EQI-A nrPDB Length = 69 Score = 64.1 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 18/69 (26%), Positives = 32/69 (46%), Gaps = 1/69 (1%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYV 65 +S SG A Y++ +L FC+G ++ V+ + W+K + P+NYV Sbjct: 2 SSGSSGRTVKALYDYKAKRSDELTFCRGALIHNVSK-EPGGWWKGDYGTRIQQYFPSNYV 60 Query: 66 QKREGVKAG 74 + G +G Sbjct: 61 EDISGPSSG 69 >2CUC-A nrPDB Length = 70 Score = 63.7 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 34/70 (48%), Gaps = 2/70 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNK-VGREGIIPANY 64 +S SG +A + + ++L KG+ + ++ +D W K + GR GI P++Y Sbjct: 2 SSGSSGNMFVALHTYSAHRPEELDLQKGEGIRVLGKYQDG-WLKGLSLLTGRTGIFPSDY 60 Query: 65 VQKREGVKAG 74 V G +G Sbjct: 61 VIPVSGPSSG 70 >2ED0-A nrPDB Length = 78 Score = 63.4 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 35/79 (44%), Gaps = 12/79 (15%) Query: 6 ASWPSG----------TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVG 55 +S SG + +A Y++ E +L F +G ++ ++ D WY+ G Sbjct: 2 SSGSSGDPPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDG-WYEG-VMNG 59 Query: 56 REGIIPANYVQKREGVKAG 74 G+ P NYV+ G +G Sbjct: 60 VTGLFPGNYVESISGPSSG 78 >1WI7-A nrPDB Length = 68 Score = 62.6 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 36/69 (52%), Gaps = 2/69 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYV 65 +S SG C +++ + +L GD++ +V ++ W++ G+ G+ P+N++ Sbjct: 2 SSGSSGRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEG-WWEG-VLNGKTGMFPSNFI 59 Query: 66 QKREGVKAG 74 ++ G +G Sbjct: 60 KELSGPSSG 68 >2IZV-A nrPDB Length = 187 Score = 61.0 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 21/94 (22%), Positives = 38/94 (40%), Gaps = 4/94 (4%) Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYH 134 +++ P + G + + AE LL G FL+R+S +++ + H RI Sbjct: 29 LQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQW 88 Query: 135 ASKLSIDEEV--YFEN--LMQLVEHYTTDADGLC 164 S D F + + L+EHY + + Sbjct: 89 NHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMF 122 >2ENM-A nrPDB Length = 77 Score = 60.7 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 32/66 (48%), Gaps = 3/66 (4%) Query: 6 ASWPSG--TECIAKYNFHGT-AEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPA 62 +S SG T+ Y+F +L +G+++T+ W + KN G +G++P Sbjct: 2 SSGSSGMATKARVMYDFAAEPGNNELTVTEGEIITVTNPNVGGGWLEGKNNKGEQGLVPT 61 Query: 63 NYVQKR 68 +YV+ Sbjct: 62 DYVEIL 67 >1GCQ-A nrPDB Length = 61 Score = 59.5 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 18/58 (31%), Positives = 30/58 (51%), Gaps = 2/58 (3%) Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKRE 69 T A ++F + +L F +GD + ++ + DPNW+K G+ G+ P NYV Sbjct: 3 TYVQALFDFDPQEDGELGFRRGDFIHVMDNS-DPNWWKGACH-GQTGMFPRNYVTPVN 58 >1NM7-A nrPDB Length = 69 Score = 59.1 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 5/60 (8%) Query: 14 CIAKYNFHGTAEQ-DLPFCKGDVLTIVAVTK----DPNWYKAKNKVGREGIIPANYVQKR 68 A Y+F + ++ KGD++ I++ D +W+K + K G G IP NY++ Sbjct: 10 ARALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRTKNGNIGYIPYNYIEII 69 >2V1R-A nrPDB Length = 80 Score = 59.1 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 20/66 (30%), Positives = 33/66 (50%), Gaps = 6/66 (9%) Query: 9 PSGTE-CIAKYNFHGTAEQ-DLPFCKGDVLTIVAVTK----DPNWYKAKNKVGREGIIPA 62 PS E A Y+F + ++ KGD++ I++ D +W+K + K G G IP Sbjct: 11 PSKLEFARALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRTKNGNIGYIPY 70 Query: 63 NYVQKR 68 NY++ Sbjct: 71 NYIEII 76 >2NWM-A nrPDB Length = 65 Score = 58.7 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 2/57 (3%) Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 K++F + ++L KGD++ I D NW + ++ GR GI PANYV+ Sbjct: 2 KAARLKFDFQAQSPKELTLQKGDIVYIHKEV-DKNWLEGEHH-GRLGIFPANYVEVL 56 >2DJQ-A nrPDB Length = 68 Score = 58.3 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 25/69 (36%), Positives = 35/69 (50%), Gaps = 2/69 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYV 65 +S SG A N+ G DL F KGDV+ ++ D NWY+ + G GI PA+ V Sbjct: 2 SSGSSGPRAKALCNYRGKNPGDLKFNKGDVI-LLRRQLDENWYQGEI-NGVSGIFPASSV 59 Query: 66 QKREGVKAG 74 + G +G Sbjct: 60 EVISGPSSG 68 >1N5Z-A nrPDB Length = 92 Score = 58.3 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 21/78 (26%), Positives = 36/78 (46%), Gaps = 6/78 (7%) Query: 9 PSGTE-CIAKYNFHGTAEQ-DLPFCKGDVLTIVAVTK----DPNWYKAKNKVGREGIIPA 62 PS E A Y+F + ++ KGD++ I++ D +W+K + K G G IP Sbjct: 11 PSKLEFARALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRTKNGNIGYIPY 70 Query: 63 NYVQKREGVKAGTKLSLM 80 NY++ + K + Sbjct: 71 NYIEIIKRRKKIEHVDDE 88 >4N78-F nrPDB Length = 514 Score = 58.0 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 28/54 (51%), Gaps = 2/54 (3%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 + +A Y++ E +L F +G ++ ++ D WY+ G G+ P NYV+ Sbjct: 456 KVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDG-WYEG-VMNGVTGLFPGNYVE 507 >3EHQ-A nrPDB Length = 222 Score = 58.0 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 2/65 (3%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKA 73 A Y F +L +GD++ I ++ D NW+K +K GR G+IP+NYV ++ Sbjct: 17 FRALYTFEPRTPDELYIEEGDIIYITDMS-DTNWWKGTSK-GRTGLIPSNYVAEQAESID 74 Query: 74 GTKLS 78 Sbjct: 75 NPLHE 79 >5VE6-A nrPDB Length = 492 Score = 58.0 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 33/71 (46%), Gaps = 5/71 (7%) Query: 257 EEKGGLYIVTEYMAKGSLVDYLR-----SRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 +E+ + ++T + + D++R + + L +C +E+L+ + + Sbjct: 171 QEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGII 230 Query: 312 HRDLAARNVLV 322 HRDL N+L+ Sbjct: 231 HRDLCLENLLL 241 Score = 43.3 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 35/90 (38%), Gaps = 3/90 (3%) Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP-RIPLKDVVPRVEKGYKMDAPDGC 411 APE + ++ K D + GIL++E+ P+ R L++ R E + A Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELL-HQPNPFEVRAQLRERDYRQEDLPPLPALSLY 382 Query: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 P + + D R + + L+ Sbjct: 383 SPGLQQLAHLLLEADPIKRIRIGEAKRVLQ 412 >1X69-A nrPDB Length = 79 Score = 58.0 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 12/75 (16%) Query: 6 ASWPSGT----------ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVG 55 +S SGT +A Y++ + ++ F D++T + + D W++ K G Sbjct: 2 SSGSSGTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDG-WWRGVCK-G 59 Query: 56 REGIIPANYVQKREG 70 R G+ PANYV+ R+ Sbjct: 60 RYGLFPANYVELRQS 74 >1UGV-A nrPDB Length = 72 Score = 56.8 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 4/72 (5%) Query: 6 ASWPSGT---ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPA 62 +S SGT + A Y + +L F G V V +++P W + G+ G+IP Sbjct: 2 SSGSSGTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEG-TLNGKTGLIPE 60 Query: 63 NYVQKREGVKAG 74 NYV+ G +G Sbjct: 61 NYVEFLSGPSSG 72 >6M7Z-A nrPDB Length = 319 Score = 56.0 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 33/194 (17%), Positives = 67/194 (34%), Gaps = 35/194 (18%) Query: 261 GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV 320 L + ++KG + D L + + + ++ A++ L +HR + + Sbjct: 120 FLTYIFHPLSKGLVGDMLETGRSHP----DVQVLAANMVAALKSLHNLGLLHRSIELNSF 175 Query: 321 LVSEDNVAKVSDFGLTKEASSTQDTGKLPVKW---TAPEA---------LREKKFSTKSD 368 V D + GL A +T + TAPE L + + + KSD Sbjct: 176 SVLPDGTVVLG--GLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSD 233 Query: 369 VWSFGIL---LWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHL 425 V+S G+ L ++ G + + V + + ++ D Sbjct: 234 VYSLGVAFRNLVQLLGNGNL------GPEDRGAVRQDH-LELLDKLSQ-------KMIEE 279 Query: 426 DAATRPTFLQLREQ 439 + RPT ++ + Sbjct: 280 EPGNRPTIEEIMKD 293 >3ULR-B nrPDB Length = 65 Score = 55.7 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 2/59 (3%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKRE 69 G IA Y++ + ++ F D++T + + D W++ K GR G+ PANYV+ R+ Sbjct: 9 GITAIALYDYQAAGDDEISFDPDDIITNIEMIDDG-WWRGVCK-GRYGLFPANYVELRQ 65 >5NXJ-A nrPDB Length = 60 Score = 55.7 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 19/62 (30%), Positives = 33/62 (53%), Gaps = 2/62 (3%) Query: 8 WPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQK 67 G IA Y++ + ++ F D++T + + D W++ K GR G+ PANYV+ Sbjct: 1 GHMGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDG-WWRGVCK-GRYGLFPANYVEL 58 Query: 68 RE 69 R+ Sbjct: 59 RQ 60 >2JT4-A nrPDB Length = 71 Score = 54.9 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 15/67 (22%), Positives = 31/67 (46%), Gaps = 1/67 (1%) Query: 10 SGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKR 68 S I +Y+F ++ +L GD + I+ K +W+ + G+ G++PA +++ Sbjct: 5 SKKRGIVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIEPV 64 Query: 69 EGVKAGT 75 K Sbjct: 65 RDKKHTE 71 >1UHF-A nrPDB Length = 69 Score = 54.5 bits (130), Expect = 8e-08, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 3/58 (5%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREG 70 E IA Y + DL F +G+ I+ KD W+ R GI P+NYV+ ++ Sbjct: 10 EYIALYPYSSVEPGDLTFTEGE--EILVTQKDGEWWTGSIGD-RSGIFPSNYVKPKDS 64 >2HSP-A nrPDB Length = 71 Score = 53.7 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 11/63 (17%), Positives = 26/63 (41%), Gaps = 1/63 (1%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREG 70 A +++ E +L F K ++ V + W++ ++ P+NYV++ Sbjct: 6 KCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGG-WWRGDYGGKKQLWFPSNYVEEMVN 64 Query: 71 VKA 73 + Sbjct: 65 PEG 67 >2K9G-A nrPDB Length = 73 Score = 53.7 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 32/65 (49%), Gaps = 2/65 (3%) Query: 3 AIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTK-DPNWYKAKNKVGREGIIP 61 ++ + S C + + + +L +GD++T++ D W++ + GR G+ P Sbjct: 1 SMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGEL-NGRRGVFP 59 Query: 62 ANYVQ 66 N+V+ Sbjct: 60 DNFVK 64 >1YWO-A nrPDB Length = 64 Score = 53.7 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 12/56 (21%), Positives = 26/56 (46%), Gaps = 1/56 (1%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 + A +++ E +L F K ++ V +D W++ ++ P+NYV+ Sbjct: 6 KSAVKALFDYKAQREDELTFTKSAIIQNVEK-QDGGWWRGDYGGKKQLWFPSNYVE 60 >5JMQ-A nrPDB Length = 446 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 2/55 (3%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQK 67 E +A ++ T E L F +G+ + I+ T W+ + G G IPAN++ K Sbjct: 47 EFVAIADYTATDETQLSFLRGEKILILRQTTADWWWGER--AGCCGYIPANHLGK 99 >5O2P-A nrPDB Length = 100 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 29/60 (48%), Gaps = 3/60 (5%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDP--NWYKAKNKVGREGIIPANYVQKREGV 71 A Y+ + +L F KGD++T++ W+ GR+GI+P N ++ G+ Sbjct: 10 AKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLCSLH-GRQGIVPGNRLKILVGM 68 >2K6D-A nrPDB Length = 62 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 14/58 (24%), Positives = 29/58 (50%), Gaps = 2/58 (3%) Query: 10 SGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTK-DPNWYKAKNKVGREGIIPANYVQ 66 S C + + + +L +GD++T++ D W++ + GR G+ P N+V+ Sbjct: 2 SKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGEL-NGRRGVFPDNFVK 58 >1SPK-A nrPDB Length = 72 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 31/71 (43%), Gaps = 2/71 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDL-PFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPAN 63 +S SG + + + L F +GDVLT++ + W ++ + G P++ Sbjct: 2 SSGSSGQKVKTIFPHTAGNNKTLLSFAQGDVLTLLIPEEKDGWLYGEHDTTKARGWFPSS 61 Query: 64 YVQKREGVKAG 74 Y + G +G Sbjct: 62 YTKLLSGPSSG 72 >5O2M-A nrPDB Length = 81 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 29/60 (48%), Gaps = 3/60 (5%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDP--NWYKAKNKVGREGIIPANYVQKREGV 71 A Y+ + +L F KGD++T++ W+ GR+GI+P N ++ G+ Sbjct: 10 AKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLCSLH-GRQGIVPGNRLKILVGM 68 >1K4U-S nrPDB Length = 62 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 34/56 (60%), Gaps = 2/56 (3%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 G++ A +++ T +DL F +GD++ +++ + W + ++K G+ GI P +V+ Sbjct: 5 GSQVEALFSYEATQPEDLEFQEGDIILVLSKVNE-EWLEGESK-GKVGIFPKVFVE 58 >5O2Q-A nrPDB Length = 99 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 29/60 (48%), Gaps = 3/60 (5%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDP--NWYKAKNKVGREGIIPANYVQKREGV 71 A Y+ + +L F KGD++T++ W+ GR+GI+P N ++ G+ Sbjct: 10 AKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLCSLH-GRQGIVPGNRLKILVGM 68 >2YDL-A nrPDB Length = 69 Score = 53.3 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 13/60 (21%), Positives = 30/60 (50%), Gaps = 2/60 (3%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTK-DPNWYKAKNKVGREGIIPANYVQKREGVK 72 C + + + +L +GD++T++ D W++ + GR G+ P N+V+ ++ Sbjct: 5 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGEL-NGRRGVFPDNFVKLLPPLE 63 >1WXU-A nrPDB Length = 93 Score = 53.0 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 37/89 (41%), Gaps = 13/89 (14%) Query: 6 ASWPSGTE----------CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDP---NWYKAKN 52 +S SGT A+Y+F +++++ F GD+L + + P W A Sbjct: 2 SSGSSGTNWASGEDDHVVARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASL 61 Query: 53 KVGREGIIPANYVQKREGVKAGTKLSLMP 81 G+IPANYV+ + + P Sbjct: 62 DGQTTGLIPANYVKILGKRRGRKTIESGP 90 >2V1Q-A nrPDB Length = 60 Score = 53.0 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 29/55 (52%), Gaps = 1/55 (1%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKR 68 I +Y+F ++ +L GD + I+ K +W+ + G+ G++PA +++ Sbjct: 6 IVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIEPV 60 >4AZW-A nrPDB Length = 471 Score = 52.6 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 38/114 (33%), Gaps = 13/114 (11%) Query: 225 KNDATAQAFLAEASVMTQ----LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS 280 ++ E +TQ ++ E ++V E + L D L + Sbjct: 280 ESQRNKHELHNEIKFLTQPPAGFDAPAVL----AHGENAQSGWLVMEKLPGRLLSDMLAA 335 Query: 281 RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG 334 K + ++ LE F H D+ NV+V A++ DFG Sbjct: 336 G-----EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >2O2O-A nrPDB Length = 92 Score = 52.6 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 31/61 (50%), Gaps = 2/61 (3%) Query: 18 YNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKL 77 +++ + +L GD++ +V ++ W++ G+ G+ P+N++++ G + Sbjct: 25 FSYLPQNDDELELKVGDIIEVVGEVEEG-WWEG-VLNGKTGMFPSNFIKELSGESDELGI 82 Query: 78 S 78 S Sbjct: 83 S 83 >4AZV-A nrPDB Length = 569 Score = 52.6 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 18/72 (25%), Positives = 29/72 (40%), Gaps = 5/72 (6%) Query: 263 YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLV 322 ++V E + L D L + K + ++ LE F H D+ NV+V Sbjct: 318 WLVMEKLPGRLLSDMLAAG-----EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMV 372 Query: 323 SEDNVAKVSDFG 334 A++ DFG Sbjct: 373 DARQHARLIDFG 384 >1J3T-A nrPDB Length = 74 Score = 51.8 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 6/72 (8%) Query: 6 ASWPSGTE---CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPA 62 +S SG E A ++ + L F K D++T++ + NW+ + GR G P Sbjct: 2 SSGSSGVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQE--NWWFGEVHGGR-GWFPK 58 Query: 63 NYVQKREGVKAG 74 +YV+ G ++G Sbjct: 59 SYVKIIPGSESG 70 >2DMO-A nrPDB Length = 68 Score = 51.0 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 33/69 (47%), Gaps = 2/69 (2%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYV 65 +S SG + F +++L G+++ ++ D NW G++G++P NY+ Sbjct: 2 SSGSSGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGND-NWATVMF-NGQKGLVPCNYL 59 Query: 66 QKREGVKAG 74 + G +G Sbjct: 60 EPVSGPSSG 68 >4WWA-A nrPDB Length = 261 Score = 49.9 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 28/137 (20%), Positives = 52/137 (37%), Gaps = 18/137 (13%) Query: 224 IKNDATAQAFLAEASVMTQLRH-SNL-VQLLGVIVEEKGGLYIVT--EYMAKG----SLV 275 I T L E+ ++ +L L V L G +++ E + G +L Sbjct: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLK 123 Query: 276 DYLRSRGRSVLG---GDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDN---VAK 329 ++L + L K + + L N++ H DL + N+++ D Sbjct: 124 NFLWMHDQDPYSDLVATTLRKVGRQI--GL--LHWNDYCHGDLTSSNIVLVRDGARWTPH 179 Query: 330 VSDFGLTKEASSTQDTG 346 + DFGL ++ +D G Sbjct: 180 LIDFGLGSVSNLVEDKG 196 >5XHZ-A nrPDB Length = 66 Score = 49.9 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 10/53 (18%), Positives = 29/53 (54%), Gaps = 2/53 (3%) Query: 18 YNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREG 70 +++ + +L GD++ +V ++ W++ G+ G+ P+N++++ G Sbjct: 16 FSYLPQNDDELELKVGDIIEVVGEVEEG-WWEG-VLNGKTGMFPSNFIKELSG 66 >4CYJ-A nrPDB Length = 438 Score = 49.5 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 18/152 (11%), Positives = 53/152 (34%), Gaps = 26/152 (17%) Query: 202 GKGEFGD---VMLGDY--RGNKVAVKCIKNDATAQAFLAEASVM------TQLRHSNLVQ 250 FG V G A++ ++ E +++ +++++++V Sbjct: 61 NTSCFGYPSWVYKAQNSRNGRHYALRRLEGY----RLTNEKAILNVMKDWKKIKNASIVT 116 Query: 251 LLGVIVEE---KGGLYIVTEYMAKG-SLVDYL-------RSRGRSVLGGDCLLKFSLDVC 299 + V L ++ +L ++ R R + + + + + Sbjct: 117 IHEVFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIA 176 Query: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVS 331 A++ + N R L +++++ N ++S Sbjct: 177 NALKTIHSNRLAARCLEPSKIILTDINRIRLS 208 >2VKN-A nrPDB Length = 70 Score = 49.5 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 27/46 (58%), Gaps = 2/46 (4%) Query: 27 DLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72 ++ F + ++L + + W+KA+ G GIIP+NYVQ +G + Sbjct: 23 EISFEQNEILQV--SDIEGRWWKARRANGETGIIPSNYVQLIDGPE 66 >3ENH-A nrPDB Length = 540 Score = 49.1 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 52/159 (32%), Gaps = 23/159 (14%) Query: 198 LQTIGKGEFGDVMLGDYRGNKVAVK----------CIKNDATAQAFLAEASVMTQLRHSN 247 IGKG D+ Y V +K + + EA + ++ Sbjct: 341 EHLIGKGAEADIKRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFG 400 Query: 248 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEG 307 + + + I+ Y+ D + L + + E + L Sbjct: 401 IPAPY-IFDVDLDNKRIMMSYINGKLAKDVIEDN----------LDIAYKIGEIVGKLHK 449 Query: 308 NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG 346 N+ +H DL N + +D + DFGL K ++ +D Sbjct: 450 NDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKA 486 >1I07-A nrPDB Length = 60 Score = 48.7 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 25/62 (40%), Gaps = 2/62 (3%) Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREG 70 +KY+F +L K DVL I+ W+K +N G G +P N + Sbjct: 1 KKYAKSKYDFVARNSSELSVMKDDVLEIL--DDRRQWWKVRNASGDSGFVPNNILDIMRT 58 Query: 71 VK 72 + Sbjct: 59 PE 60 >1UE9-A nrPDB Length = 80 Score = 48.7 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 27/70 (38%), Gaps = 3/70 (4%) Query: 6 ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNW---YKAKNKVGREGIIPA 62 +S SG + + + L G ++ I+ W +A+ K ++G PA Sbjct: 2 SSGSSGEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPA 61 Query: 63 NYVQKREGVK 72 ++V+ Sbjct: 62 SHVKLLGPSS 71 >2ED1-A nrPDB Length = 76 Score = 47.9 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 33/76 (43%), Gaps = 6/76 (7%) Query: 6 ASWPSGTECI---AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKA--KNKVGREGII 60 +S SG + Y+ + +L F +G+V+ IV +D W+ + + R+G+ Sbjct: 2 SSGSSGNKVRRVKTIYDCQADNDDELTFIEGEVI-IVTGEEDQEWWIGHIEGQPERKGVF 60 Query: 61 PANYVQKREGVKAGTK 76 P ++V + Sbjct: 61 PVSFVHILSDSGPSSG 76 >3DZO-A nrPDB Length = 413 Score = 47.9 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 38/264 (14%), Positives = 89/264 (33%), Gaps = 51/264 (19%) Query: 220 AVKCIKNDATAQAFLAEASVMTQLR-HSNLV------------QLLGVIVEEKGGLYIVT 266 A+K +K + L Q + H + +++ V ++E+ +++++ Sbjct: 121 AIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERD-MWVLS 179 Query: 267 EYMAKGSLVDYLRSRGRSVLGG---------DCLLKFSLDVCEAMEYLEGNNFVHRDLAA 317 + + L++ G +L L+ +L V + L VH L Sbjct: 180 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRP 239 Query: 318 RNVLVSEDNVAKVSDFG-LTKEASSTQDTGKLPVKWTAPE-----ALREKKF-----STK 366 ++++ + ++ F L ++ +S + + PE L + + Sbjct: 240 VDIVLDQRGGVFLTGFEHLVRDGASAVSP--IGRGFAPPETTAERMLPFGQHHPTLMTFA 297 Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 D W+ G+ ++ I+ +P D + + P V +++ Sbjct: 298 FDTWTLGLAIYWIWC------ADLPNTDDAALGGSEWIFRSCKNIPQPVRALLEGFLRYP 351 Query: 427 AATR---------PTFLQLREQLE 441 R P + QLR +L Sbjct: 352 KEDRLLPLQAMETPEYEQLRTELS 375 >1UUS-A nrPDB Length = 473 Score = 47.6 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 17/78 (21%), Positives = 34/78 (43%), Gaps = 10/78 (12%) Query: 84 HGKITREQAERLLYPPETGLFLVRESTNYPGDYTLC---VSCEGKVEHYRIMYHASKL-- 138 +G + R++ L + G F++R S PG + + V +++HY + + + Sbjct: 355 YGYMGRQEVNDALQNQDPGTFIIRFSERNPGQFGIAYIGVEMPARIKHYLVQPNDTAAAK 414 Query: 139 -----SIDEEVYFENLMQ 151 + E F NL+Q Sbjct: 415 KTFPDFLSEHSQFVNLLQ 432 >2PZ1-A nrPDB Length = 466 Score = 46.8 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 15/51 (29%), Positives = 27/51 (52%), Gaps = 2/51 (3%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 A ++ +Q+L F GDV+ ++ T W+ + G EG PA++V+ Sbjct: 35 ALWDHVTMDDQELGFKAGDVIEVMDATNREWWW-GRVADG-EGWFPASFVR 83 >2CR4-A nrPDB Length = 126 Score = 46.8 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 3/65 (4%) Query: 97 YPPETGLFLVRESTNYPGDYTLCV--SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVE 154 P+ GL+ +R S+ G L V KV +YRI SK ++ EV F ++ +VE Sbjct: 40 GEPQDGLYCIRNSSTKSGK-VLVVWDETSNKVRNYRIFEKDSKFYLEGEVLFVSVGSMVE 98 Query: 155 HYTTD 159 HY T Sbjct: 99 HYHTH 103 >3BYV-A nrPDB Length = 377 Score = 45.6 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 35/265 (13%), Positives = 90/265 (33%), Gaps = 52/265 (19%) Query: 220 AVKCIKNDATAQAFLAEASVMTQLR-HSNLV------------QLLGVIVEEKGGLYIVT 266 A+K +K + L Q + H + +++ V ++E+ +++++ Sbjct: 116 AIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERD-MWVLS 174 Query: 267 EYMAKGSLVDYLRSRGRSVLGG---------DCLLKFSLDVCEAMEYLEGNNFVHRDLAA 317 + + L++ G +L L+ +L V + L VH L Sbjct: 175 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRP 234 Query: 318 RNVLVSEDNVAKVSDFG-LTKEASSTQDTGKLPVKWTAPEA------LREKK-----FST 365 ++++ + ++ F L ++ + + + + PE + + + Sbjct: 235 VDIVLDQRGGVFLTGFEHLVRDGARVVSS--VSRGFEPPELEARRATISYHRDRRTLMTF 292 Query: 366 KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHL 425 D W+ G++++ I+ +P+ + + P V +++ Sbjct: 293 SFDAWALGLVIYWIWC------ADLPITKDAALGGSEWIFRSCKNIPQPVRALLEGFLRY 346 Query: 426 DAATR---------PTFLQLREQLE 441 R P + QLR +L Sbjct: 347 PKEDRLLPLQAMETPEYEQLRTELS 371 >2W1Z-A nrPDB Length = 368 Score = 45.6 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 40/260 (15%), Positives = 82/260 (31%), Gaps = 42/260 (16%) Query: 220 AVKCIKNDATAQAFLAEASVMTQ-------------LRHSNLVQLLGVIVEEKGGLYIV- 265 A+K + L Q ++ +++ V ++E+ + Sbjct: 101 AIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLSR 160 Query: 266 TEYMAKGS-----LVDYL--RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAAR 318 + L D L S L L+ +L + L+ VH D R Sbjct: 161 FFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVR 220 Query: 319 NVLVSEDNVAKVSDFG-LTKEASSTQDTGKLPVKWTAPE-----ALREKKF-----STKS 367 N+L+ + ++ F L ++ +S + + PE L ++ + Sbjct: 221 NILLDQRGGVFLTGFEHLVRDGASAVSP--IGRGFAPPETTAERMLPYRQHHPTLMTFPF 278 Query: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDA 427 D W+ G+ ++ I+ +P + + P V +++ Sbjct: 279 DTWTLGLAIYWIWC------ADLPNTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSK 332 Query: 428 ATRPTFLQLRE--QLEHIRT 445 R LQ E + E +RT Sbjct: 333 EDRLLPLQAMETSEYEQLRT 352 >2MIO-A nrPDB Length = 70 Score = 45.3 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 25/54 (46%), Gaps = 1/54 (1%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQ 66 + A Y +L F G + V +++P W + G+ G+IP NYV+ Sbjct: 16 KARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEG-TLNGKRGLIPQNYVK 68 >1UEC-A nrPDB Length = 193 Score = 45.3 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 14/73 (19%), Positives = 32/73 (43%), Gaps = 4/73 (5%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72 A ++ T+ ++ GDV+ +V ++ W+ + K + G IPA++++ + Sbjct: 13 TYRAIADYEKTSGSEMALSTGDVVEVVEKSESG-WWFCQMKA-KRGWIPASFLEPLDSPD 70 Query: 73 AGTKLSLMPWFHG 85 P + G Sbjct: 71 ETE--DPEPNYAG 81 Score = 40.2 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 23/59 (38%), Gaps = 2/59 (3%) Query: 10 SGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 +G +A + ++ +G+ + ++ D W K G P+ Y+QK Sbjct: 80 AGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGYFPSMYLQKS 136 >3MAZ-A nrPDB Length = 125 Score = 44.9 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 20/98 (20%), Positives = 46/98 (46%), Gaps = 7/98 (7%) Query: 77 LSLMPWFHGKITREQAERLLY-PPETGLFLVRESTNYPGDYTLCVSCE---GKVEHYRIM 132 L+ MP ++R++A +L P G ++R ++ Y++ + E +++HY++M Sbjct: 12 LNPMPACFYTVSRKEATEMLQKNPSLGNMILRPGSDSRN-YSITIRQEIDIPRIKHYKVM 70 Query: 133 YHASKLSIDEEV--YFENLMQLVEHYTTDADGLCTRLI 168 +I+ E NL +++++ + G I Sbjct: 71 SVGQNYTIELEKPVTLPNLFSVIDYFVKETRGNLRPFI 108 >1OV3-A nrPDB Length = 138 Score = 44.9 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 14/73 (19%), Positives = 32/73 (43%), Gaps = 4/73 (5%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72 A ++ T+ ++ GDV+ +V ++ W+ + K + G IPA++++ + Sbjct: 13 TYRAIADYEKTSGSEMALSTGDVVEVVEKSESG-WWFCQMKA-KRGWIPASFLEPLDSPD 70 Query: 73 AGTKLSLMPWFHG 85 P + G Sbjct: 71 ETE--DPEPNYAG 81 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 23/59 (38%), Gaps = 2/59 (3%) Query: 10 SGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 +G +A + ++ +G+ + ++ D W K G P+ Y+QK Sbjct: 80 AGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWW--VIRKDDVTGYFPSMYLQKS 136 >6G38-A nrPDB Length = 357 Score = 44.9 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 33/181 (18%), Positives = 57/181 (31%), Gaps = 54/181 (29%) Query: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCI----------KNDATAQAFLAEASV 239 L ++L+ + IG+G FG+V VA+K I + T + L E + Sbjct: 38 LPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIII 97 Query: 240 MTQL---------RHSNLVQLLGV------------------------------IVEEKG 260 +L R + L V ++ Sbjct: 98 SKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKD-D 156 Query: 261 GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE-GNNFVHRDLAARN 319 L+IV E+ G ++ +R++ + ++ E F HRDL N Sbjct: 157 QLFIVLEFEFGGIDLEQMRTKLS---SLATAKSILHQLTASLAVAEASLRFEHRDLHWGN 213 Query: 320 V 320 V Sbjct: 214 V 214 >2M0Y-A nrPDB Length = 74 Score = 44.5 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 16/59 (27%), Positives = 29/59 (49%), Gaps = 4/59 (6%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKA--KNKVGREGIIPANYVQKREGV 71 +A YN+ +L GD + I+ + WY+ K ++GI PA+Y+ +E + Sbjct: 15 VAFYNYDARGADELSLQIGDTVHILETYEG--WYRGYTLRKKSKKGIFPASYIHLKEAI 71 >4MT6-A nrPDB Length = 456 Score = 44.5 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 30/65 (46%), Gaps = 2/65 (3%) Query: 2 SAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIP 61 S + + S A ++ A ++L F GDV+ ++ + W+ + EG P Sbjct: 8 SGMLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDE--EGWFP 65 Query: 62 ANYVQ 66 A++V+ Sbjct: 66 ASFVR 70 >4IIO-A nrPDB Length = 66 Score = 44.5 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 27/56 (48%), Gaps = 3/56 (5%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 + A ++ + L F K D++T++ + NW+ + GR G P +YV+ Sbjct: 10 KAQALCSWTAKKDNHLNFSKHDIITVLEQQE--NWWFGEVHGGR-GWFPKSYVKII 62 >1Z9Q-A nrPDB Length = 79 Score = 43.7 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 14/53 (26%), Positives = 28/53 (52%), Gaps = 2/53 (3%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 A ++F G ++ +L F GDV+ +++ +W + G GI P ++V+ Sbjct: 23 ALFDFTGNSKLELNFKAGDVIFLLSRIN-KDWLEG-TVRGATGIFPLSFVKIL 73 >2DYB-A nrPDB Length = 341 Score = 43.7 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 14/53 (26%), Positives = 28/53 (52%), Gaps = 2/53 (3%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 A ++F G ++ +L F GDV+ +++ +W + G GI P ++V+ Sbjct: 179 ALFDFTGNSKLELNFKAGDVIFLLSRIN-KDWLEG-TVRGATGIFPLSFVKIL 229 >1W6X-A nrPDB Length = 60 Score = 43.7 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 14/53 (26%), Positives = 28/53 (52%), Gaps = 2/53 (3%) Query: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 A ++F G ++ +L F GDV+ +++ +W + G GI P ++V+ Sbjct: 9 ALFDFTGNSKLELNFKAGDVIFLLSRIN-KDWLEG-TVRGATGIFPLSFVKIL 59 >1TQM-A nrPDB Length = 282 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 48/139 (34%), Gaps = 25/139 (17%) Query: 205 EFGDVMLGDYRGNKVAVKCIKNDAT----------AQAFLAEASVMTQLRHSNLVQLLGV 254 +FG+ ++ ++ + K +K ++ E + +L+ + ++ Sbjct: 113 KFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARNEFRALQKLQGLAVPKVYAW 172 Query: 255 IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 ++ E + L VL +V + + VH D Sbjct: 173 EGNA-----VLMELIDAKELYRVRVENPDEVLDM-----ILEEVAK---FYH-RGIVHGD 218 Query: 315 LAARNVLVSEDNVAKVSDF 333 L+ NVLVSE+ + DF Sbjct: 219 LSQYNVLVSEEG-IWIIDF 236 >2EL8-A nrPDB Length = 118 Score = 42.2 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 7/90 (7%) Query: 86 KITREQAERLLYP-PETGLFLVRESTNYPGDYTLCVS--CEGK--VEHYRIMYHASKLSI 140 K++R +A+ LL PE G L+R S + ++ G V HY++ K I Sbjct: 27 KVSRLEAQLLLERYPECGNLLLRPSGDGADGVSVTTRQMHNGTHVVRHYKVKREGPKYVI 86 Query: 141 DEEVYFE--NLMQLVEHYTTDADGLCTRLI 168 D E F +L +V ++ + + Sbjct: 87 DVEQPFSCTSLDAVVNYFVSHTKKALVPFL 116 >2CUD-A nrPDB Length = 79 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 25/59 (42%), Gaps = 3/59 (5%) Query: 17 KYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKA-KNKVGREGIIPANYVQKREGVKAG 74 ++ F +G+ L ++ + + W+KA GRE IP V + G +G Sbjct: 23 LSDYPSPDISPPIFRRGEKLRVI--SDEGGWWKAISLSTGRESYIPGICVARVSGPSSG 79 >2KYM-A nrPDB Length = 120 Score = 41.8 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 17/58 (29%), Positives = 30/58 (51%), Gaps = 3/58 (5%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAK--NKVGREGIIPANYVQKRE 69 + Y F + +L G+ L+I A D W+ AK N++G G++P +YV+ + Sbjct: 6 AVTLYEFKAERDDELDVSPGENLSICAH-YDYEWFIAKPINRLGGPGLVPVSYVRIID 62 >4WSI-A nrPDB Length = 394 Score = 41.4 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 26/111 (23%), Positives = 47/111 (42%), Gaps = 14/111 (12%) Query: 9 PSGTECI---AKYNFHGTA-------EQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREG 58 P+ I A +++ + E L F KGD+L +++ +DPNW++A + G E Sbjct: 111 PAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQ-EDPNWWQA-YREGDED 168 Query: 59 IIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRES 109 P + G + M +H R++ L+ P G +R+ Sbjct: 169 NQPLAGLVP--GKEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQR 217 >2RQT-A nrPDB Length = 61 Score = 41.4 bits (96), Expect = 9e-04, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 27/55 (49%), Gaps = 3/55 (5%) Query: 17 KYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKA--KNKVGREGIIPANYVQKRE 69 Y+ + +L F +G+V+ IV +D W+ + + R+G+ P ++V Sbjct: 7 IYDCQADNDDELTFIEGEVI-IVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILS 60 >4BWP-A nrPDB Length = 448 Score = 41.0 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 20/138 (14%), Positives = 40/138 (28%), Gaps = 39/138 (28%) Query: 210 MLGDY--RGNKVAVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE---KGG 261 + G K ++ I + +T L E +L+H+N+VQL V + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMW--KKLQHTNVVQLREVFTTKAFGDNS 124 Query: 262 LYIVTEYMAKGS--LVDYL---------------------------RSRGRSVLGGDCLL 292 L +V +Y L Y R+ +L + Sbjct: 125 LVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIW 184 Query: 293 KFSLDVCEAMEYLEGNNF 310 + + ++ + Sbjct: 185 SIIMQLTAGLKAIHHAGL 202 >2RQR-A nrPDB Length = 119 Score = 41.0 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 16/57 (28%), Positives = 26/57 (45%), Gaps = 4/57 (7%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN--KVGREGIIPANYVQKRE 69 +A YNF G+ L GDV+ I +WY+ +GI P +++ +E Sbjct: 63 VAIYNFQGSGAPQLSLQIGDVVRI--QETCGDWYRGYLIKHKMLQGIFPKSFIHIKE 117 >3A98-A nrPDB Length = 184 Score = 40.2 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 30/76 (39%), Gaps = 14/76 (18%) Query: 6 ASWPSGTE----------CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN--K 53 +S SG +A YNF G+ L GDV+ I +WY+ Sbjct: 2 SSGSSGMAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRI--QETCGDWYRGYLIKH 59 Query: 54 VGREGIIPANYVQKRE 69 +GI P +++ +E Sbjct: 60 KMLQGIFPKSFIHIKE 75 >4CZY-B nrPDB Length = 429 Score = 40.2 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 19/142 (13%), Positives = 46/142 (32%), Gaps = 25/142 (17%) Query: 210 MLGDYR--GNKVAVKCIKNDATAQAFLAEASVM------TQLRHSNLVQLLGVIVEE--- 258 G A++ I E +++ ++ ++N+V + E Sbjct: 61 YKAQNNKNGRHFALRRI----EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFG 116 Query: 259 KGGLYIVTEYMAKGS-LVDYL--------RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNN 309 L V ++ L D+ R R + + + L + + A+ + Sbjct: 117 DSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAK 176 Query: 310 FVHRDLAARNVLVSEDNVAKVS 331 R L + + E+N +++ Sbjct: 177 LAARCLELSKI-IWENNRIRLA 197 >3RNJ-A nrPDB Length = 67 Score = 39.9 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 10/64 (15%), Positives = 25/64 (39%), Gaps = 2/64 (3%) Query: 8 WPSGTECIAKYNFHGTAEQDL-PFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYV 65 A ++ L F +GD++T++ W+ +++ + G P +Y Sbjct: 4 GSGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYT 63 Query: 66 QKRE 69 + + Sbjct: 64 RVLD 67 >2KXC-A nrPDB Length = 67 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 26/49 (53%), Gaps = 1/49 (2%) Query: 22 GTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKRE 69 G+ + L F +GDV+T++ + W ++ V + G P++Y + E Sbjct: 18 GSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLE 66 >1U3O-A nrPDB Length = 82 Score = 39.1 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 10/63 (15%), Positives = 25/63 (39%), Gaps = 5/63 (7%) Query: 6 ASWPSGTE-CIAKYNFHGTAEQDLPFCKGDVLTIVAVT-KDPNWYKAKNKV---GREGII 60 ++ G E + +F +L G + ++ + P W + +EG++ Sbjct: 11 STLSGGCELTVVLQDFSAAHSSELSIQVGQTVELLERPSERPGWCLVRTTERSPPQEGLV 70 Query: 61 PAN 63 P++ Sbjct: 71 PSS 73 >3Q60-A nrPDB Length = 371 Score = 37.9 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 25/159 (15%), Positives = 51/159 (32%), Gaps = 24/159 (15%) Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALR--EKK 362 L+ VH N+ + D + D + + +PV + E L Sbjct: 210 LQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPVTYAPREFLNASTAT 269 Query: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG----------CP 412 F+ + W G+ ++ ++ +P+ + + K + P P Sbjct: 270 FTHALNAWQLGLSIYRVWCL-FLPFGLVTPG--IKGSWKRPSLRVPGTDSLAFGSCTPLP 326 Query: 413 PAVYDVMKNCWHLDAATR---------PTFLQLREQLEH 442 V ++ + D R P FLQL+ ++ Sbjct: 327 DFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISS 365 >6DFL-A nrPDB Length = 259 Score = 37.2 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 50/165 (30%), Gaps = 13/165 (7%) Query: 199 QTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEE 258 + G+G F + G G +A + E + +L + + + V E Sbjct: 42 EVDGRGYFVKIHRGIGWGE-IAKNLLTAKLPVLGARQEWQAIRRLHEAGVATMTAVAYGE 100 Query: 259 KG------GLYIVTE-YMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 +G +IVTE L + + V + + Sbjct: 101 RGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVN 160 Query: 312 HRD--LAARNVLVSEDNVAKVSDFGLT-KEASSTQDTGKLPVKWT 353 HRD + + L+ D DF L+ + Q P +W Sbjct: 161 HRDCYIC--HFLLHTDKPVSADDFRLSVIDLHRAQTRDATPKRWR 203 >2RQW-A nrPDB Length = 105 Score = 37.2 bits (85), Expect = 0.017, Method: Composition-based stats. Identities = 15/58 (25%), Positives = 26/58 (44%), Gaps = 3/58 (5%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAK--NKVGREGIIPANYVQKRE 69 I Y+F +L G+ L I A + W+ AK ++G G++P +V + Sbjct: 5 AIVLYDFKAEKADELTTYVGENLFICAH-HNCEWFIAKPIGRLGGPGLVPVGFVSIID 61 >2GTJ-A nrPDB Length = 96 Score = 36.8 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 21/45 (46%), Gaps = 1/45 (2%) Query: 23 TAEQDLPFCKGDVLTIVAVTKDPNW-YKAKNKVGREGIIPANYVQ 66 + +L F +G+ + I+ +T +P + + G G I V+ Sbjct: 39 GGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVE 83 >2XKX-A nrPDB Length = 721 Score = 36.8 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 45/103 (43%), Gaps = 16/103 (15%) Query: 2 SAIQASWPSGTECIAKYNFHGTAE-----QDLPFCKGDVLTIVAVTKDPNWYKAK----- 51 ++++++ G A +++ T + Q L F GDVL ++ D W++A+ Sbjct: 418 ASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVID-AGDEEWWQARRVHSD 476 Query: 52 NKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAER 94 ++ G IP+ ++R + ++L W G + Q Sbjct: 477 SETDDIGFIPS---KRRVERREWSRLKAKDW--GSSSGSQGRE 514 >1Y1U-A nrPDB Length = 585 Score = 36.8 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 19/40 (47%) Query: 85 GKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEG 124 G + ++QA LL G FL+R S + G T+ + Sbjct: 469 GFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDS 508 >6G18-v nrPDB Length = 552 Score = 36.4 bits (83), Expect = 0.025, Method: Composition-based stats. Identities = 10/70 (14%), Positives = 23/70 (32%), Gaps = 8/70 (11%) Query: 264 IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS 323 +V E + L + + + + L + +H D N+++ Sbjct: 186 VVMELINGYPLCQIHHVEDPASVYDEAMELIVK--------LANHGLIHGDFNEFNLILD 237 Query: 324 EDNVAKVSDF 333 E + + DF Sbjct: 238 ESDHITMIDF 247 >5VKO-A nrPDB Length = 211 Score = 36.0 bits (82), Expect = 0.032, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 38/107 (35%), Gaps = 9/107 (8%) Query: 80 MPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKV-EHYRIM------ 132 P++ QAE L E G F++R+S+ + + + +H I Sbjct: 16 HPYYF-PFNGRQAEDYLRSKERGEFVIRQSSRGDDHLVITWKLDKDLFQHIDIQELEKEN 74 Query: 133 -YHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVA 178 K+ I + + +L Q++ Y + L + + + Sbjct: 75 PLALGKVLIVDNQKYNDLDQIIVEYLQNKVRLLNEMTSSEKFKSGTK 121 >6FDN-A nrPDB Length = 320 Score = 36.0 bits (82), Expect = 0.038, Method: Composition-based stats. Identities = 10/70 (14%), Positives = 23/70 (32%), Gaps = 8/70 (11%) Query: 264 IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS 323 +V E + L + + + + L + +H D N+++ Sbjct: 186 VVMELINGYPLCQIHHVEDPASVYDEAMELIVK--------LANHGLIHGDFNEFNLILD 237 Query: 324 EDNVAKVSDF 333 E + + DF Sbjct: 238 ESDHITMIDF 247 >3PJP-A nrPDB Length = 199 Score = 36.0 bits (82), Expect = 0.038, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 47/124 (37%), Gaps = 10/124 (8%) Query: 80 MPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKV-EHYRIM------ 132 P++ +QAE L E G F++R+S+ + + + +H I Sbjct: 10 HPYYF-PFNGKQAEDYLRSKERGDFVIRQSSRGDDHLAITWKLDKDLFQHVDIQELEKEN 68 Query: 133 -YHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVME-GTVAAQDEFYRSGWAL 190 K+ + E + +L Q++ Y + L L + + GT +F + Sbjct: 69 PLALGKVLVVEGQRYHDLDQIIVEYLQNKIRLLNELTSNEKFKAGTKKEVVKFIEDYSKV 128 Query: 191 NMKE 194 N K+ Sbjct: 129 NPKK 132 >1K1Z-A nrPDB Length = 78 Score = 34.9 bits (79), Expect = 0.070, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 18/41 (43%), Gaps = 1/41 (2%) Query: 28 LPFCKGDVLTIVAVTKDPNWYKAKNKVGRE-GIIPANYVQK 67 L GD++ + + NW++ +N E G P N V Sbjct: 35 LRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVHP 75 >3GXW-A nrPDB Length = 103 Score = 34.1 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 35/89 (39%), Gaps = 9/89 (10%) Query: 80 MPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKV-EHYRIM------ 132 P++ +QAE L E G F++R+S+ + + + +H I Sbjct: 10 HPYYF-PFNGKQAEDYLRSKERGDFVIRQSSRGDDHLAITWKLDKDLFQHVDIQEMEKEN 68 Query: 133 -YHASKLSIDEEVYFENLMQLVEHYTTDA 160 K+ + E + +L Q++ Y + Sbjct: 69 PLAMGKVLVVEGQRYHDLDQIIVEYLQNK 97 >1GCP-A nrPDB Length = 70 Score = 34.1 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 18/41 (43%), Gaps = 1/41 (2%) Query: 28 LPFCKGDVLTIVAVTKDPNWYKAKNKVGRE-GIIPANYVQK 67 L GD++ + + NW++ +N E G P N V Sbjct: 27 LRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVHP 67 >1BB9-A nrPDB Length = 115 Score = 33.3 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 11/70 (15%), Positives = 28/70 (40%), Gaps = 13/70 (18%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTK-------------DPNWYKAKNKVGREGI 59 + A++++ T +L GDV+ ++ + +W + K G+ Sbjct: 46 KVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGV 105 Query: 60 IPANYVQKRE 69 P N+ ++ + Sbjct: 106 FPENFTERVQ 115 >2DE0-X nrPDB Length = 526 Score = 33.3 bits (75), Expect = 0.21, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 24/54 (44%) Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68 IA Y ++P GD++ + D K+GR G+ P+ V+++ Sbjct: 446 IAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYKVREK 499 >1MV3-A nrPDB Length = 213 Score = 33.3 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 11/69 (15%), Positives = 27/69 (39%), Gaps = 13/69 (18%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTK-------------DPNWYKAKNKVGREGI 59 + A++++ T +L GDV+ ++ + +W + K G+ Sbjct: 144 KVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKKLEKCRGV 203 Query: 60 IPANYVQKR 68 P N+ ++ Sbjct: 204 FPENFTERV 212 >5F3Y-A nrPDB Length = 621 Score = 33.3 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 25/54 (46%), Gaps = 5/54 (9%) Query: 14 CIAKYNFHGTAEQDL-PFCKGDVLTIVAVT---KDPNWYKAKN-KVGREGIIPA 62 +A + T + L PF KGD+L + NW +N + G+ G++P Sbjct: 546 AMALQDRRATDDITLLPFKKGDLLILTKKQGLLASENWALGQNDRTGKTGLVPT 599 >4Y5W-A nrPDB Length = 549 Score = 32.9 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 33/95 (34%), Gaps = 6/95 (6%) Query: 85 GKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEG-----KVEHYRIMYHASKLS 139 G I+++ LL G FL+R S + G T+ G ++E+ + Sbjct: 431 GFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSI 490 Query: 140 IDEEVYFENLMQLVEHY-TTDADGLCTRLIKPKVM 173 +L QL Y D KP+ M Sbjct: 491 RSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQM 525 >2XP1-A nrPDB Length = 178 Score = 32.5 bits (73), Expect = 0.35, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 30/67 (44%), Gaps = 4/67 (5%) Query: 91 QAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVE-HYRIMYHASKLSIDEEVYFENL 149 ++E L FL+R+ + G L + V H +I H+ + + +FE++ Sbjct: 24 ESENYLRSSTD-DFLIRKG-SRHGYCVLVIKFASDVFVHMKIEEHSEHYTCSNK-HFEDI 80 Query: 150 MQLVEHY 156 +++ Y Sbjct: 81 DEVISVY 87 >5YK0-A nrPDB Length = 452 Score = 32.5 bits (73), Expect = 0.36, Method: Composition-based stats. Identities = 7/26 (26%), Positives = 11/26 (42%) Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFG 334 +H D N ++ D + DFG Sbjct: 286 GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >1MV0-B nrPDB Length = 81 Score = 32.5 bits (73), Expect = 0.36, Method: Composition-based stats. Identities = 11/69 (15%), Positives = 27/69 (39%), Gaps = 13/69 (18%) Query: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTK-------------DPNWYKAKNKVGREGI 59 + A++++ T +L GDV+ ++ + +W + K G+ Sbjct: 12 KVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKKLEKCRGV 71 Query: 60 IPANYVQKR 68 P N+ ++ Sbjct: 72 FPENFTERV 80 >3NPK-A nrPDB Length = 291 Score = 31.0 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 16/29 (55%) Query: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315 LL +LDV A+E++ + +H DL Sbjct: 54 NKPELLNQALDVALALEFIHTYSLIHDDL 82 >3MZV-A nrPDB Length = 341 Score = 31.0 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 12/67 (17%), Positives = 24/67 (35%), Gaps = 10/67 (14%) Query: 294 FSLDVCEAMEYLEGNNFVHRDL---------AA-RNVLVSEDNVAKVSDFGLTKEASSTQ 343 F + + +E++ +H D+ N+L + V D+ + Sbjct: 74 FHVHLAATVEFIHTATLLHDDVVDESRQRRGRPTANLLWDNKSSVLVGDYLFARSFQLMT 133 Query: 344 DTGKLPV 350 DTG + V Sbjct: 134 DTGNMRV 140 >1WFW-A nrPDB Length = 74 Score = 31.0 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 10/61 (16%), Positives = 26/61 (42%), Gaps = 6/61 (9%) Query: 19 NFHGTAEQDLPFCKGDVLTIVAVTKDPNWY-----KAKNKVGREGIIPANYVQKREGVKA 73 +++ E ++ +G+V+ ++A N + + EG +P + + G + Sbjct: 15 DYYALKENEICVSQGEVVQVLA-VNQQNMCLVYQPASDHSPAAEGWVPGSILAPFSGPSS 73 Query: 74 G 74 G Sbjct: 74 G 74 >1BF5-A nrPDB Length = 575 Score = 30.6 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 16/29 (55%) Query: 85 GKITREQAERLLYPPETGLFLVRESTNYP 113 G I++E+ LL + G FL+R S + Sbjct: 445 GFISKERERALLKDQQPGTFLLRFSESSR 473 >1YVL-A nrPDB Length = 683 Score = 30.2 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 16/29 (55%) Query: 85 GKITREQAERLLYPPETGLFLVRESTNYP 113 G I++E+ LL + G FL+R S + Sbjct: 580 GFISKERERALLKDQQPGTFLLRFSESSR 608 >4PO6-A nrPDB Length = 567 Score = 30.2 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 36/106 (33%), Gaps = 14/106 (13%) Query: 84 HGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEG---------KVEHYRIMYH 134 HG + + L PE GL+L+ ST++P L V+ ++ + I Sbjct: 432 HGPLLEPFVQAKL-RPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQ 490 Query: 135 ASKLSI-DEEVYFENLMQLVEHYTT---DADGLCTRLIKPKVMEGT 176 + F ++ +L A C L + + + Sbjct: 491 DGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPG 536 >4H05-A nrPDB Length = 273 Score = 29.8 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 6/14 (42%), Positives = 7/14 (50%) Query: 310 FVHRDLAARNVLVS 323 H DL NVL+ Sbjct: 186 VCHGDLCPDNVLLD 199 >4BVU-A nrPDB Length = 211 Score = 29.5 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 12/72 (16%), Positives = 29/72 (40%), Gaps = 8/72 (11%) Query: 254 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 V+++ G +Y+ + L D + + + + +C+ L + +H Sbjct: 101 VVIQYGGDVYLRMLRVPGTPLSDI----DTADIPDNIESLYLQLICK----LNELSIIHY 152 Query: 314 DLAARNVLVSED 325 DL N+L ++ Sbjct: 153 DLNTGNMLYDKE 164 >5VFZ-A nrPDB Length = 318 Score = 29.5 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 9/46 (19%), Positives = 19/46 (41%), Gaps = 1/46 (2%) Query: 404 KMDAPDGCPPAVYDV-MKNCWHLDAATRPTFLQLREQLEHIRTHEL 448 + P P V ++ ++ + A R + L + +R HE+ Sbjct: 111 RPKRPKSVPRPVSNLDVQRLLAVRAHKRTKAMILLAAFQGLRVHEI 156 >6DK4-A nrPDB Length = 142 Score = 29.5 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 12/57 (21%), Positives = 24/57 (42%), Gaps = 1/57 (1%) Query: 220 AVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD 276 +K + AT Q ++ + H N+ +L I +E + + T Y +L + Sbjct: 6 MLKKHELKATPQRLCV-LKILKRHEHPNIDELYIEIKKEYPSISLATVYKNLNTLQE 61 >3QFR-A nrPDB Length = 618 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 11/72 (15%), Positives = 25/72 (34%), Gaps = 2/72 (2%) Query: 375 LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFL 434 +L+E+ + P + L+ + +G ++ + + RP Sbjct: 326 VLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVV--EARRHILAILQDCPSLRPPID 383 Query: 435 QLREQLEHIRTH 446 L E L ++ H Sbjct: 384 HLCELLPRLQAH 395 >2DIA-A nrPDB Length = 113 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 19/43 (44%), Gaps = 1/43 (2%) Query: 88 TREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGK-VEHY 129 + +AE + + G + V G YTL + G+ V H+ Sbjct: 52 SGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHF 94 >4E68-A nrPDB Length = 596 Score = 29.1 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 9/29 (31%), Positives = 15/29 (51%) Query: 85 GKITREQAERLLYPPETGLFLVRESTNYP 113 G I++E+ +L G FL+R S + Sbjct: 461 GFISKERERAILSTKPPGTFLLRFSESSK 489 >4DEX-A nrPDB Length = 339 Score = 29.1 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 29/82 (35%), Gaps = 17/82 (20%) Query: 19 NFHGTAEQD-------LPFCKGDVLTIVAVTKDPNWYKAKNKVGRE-GIIPAN------- 63 ++ E D + F D L + + W K G E G IP+ Sbjct: 48 SYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMR 107 Query: 64 --YVQKREGVKAGTKLSLMPWF 83 + Q+ + K +K MP+F Sbjct: 108 LQHEQRAKEFKLHSKEKRMPFF 129 >2FNA-A nrPDB Length = 357 Score = 28.7 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 21/79 (26%), Positives = 30/79 (37%), Gaps = 8/79 (10%) Query: 233 FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS------VL 286 L EA + +LR NL+ L + + + G L DYLR Sbjct: 142 VLDEAQELVKLRGVNLLPALAYAYDNLKRIKFIMSGSEMGLLYDYLRVEDPESPLFGRAF 201 Query: 287 GGDCLLKFSLDVCEAMEYL 305 L FS + EA+E+L Sbjct: 202 STVELKPFSRE--EAIEFL 218 >6FAI-l nrPDB Length = 425 Score = 28.7 bits (63), Expect = 5.8, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 25/82 (30%), Gaps = 14/82 (17%) Query: 258 EKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAA 317 + +V E + + + + L D + L + +H D Sbjct: 181 DNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVD--------LANSGLIHCDFNE 232 Query: 318 RNVLVSE------DNVAKVSDF 333 N+++ + D V DF Sbjct: 233 FNIMIKDKLEDENDCGFVVIDF 254 >5IXB-A nrPDB Length = 108 Score = 28.7 bits (63), Expect = 5.8, Method: Composition-based stats. Identities = 11/70 (15%), Positives = 28/70 (40%), Gaps = 9/70 (12%) Query: 14 CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPN--WYKAK-------NKVGREGIIPANY 64 +A ++ + L +G V+ + + K ++ + R G P++ Sbjct: 25 AVALQDYMAPDCRFLTIHRGQVVYVFSKLKGRGRLFWGGSVQGDYYGDLAARLGYFPSSI 84 Query: 65 VQKREGVKAG 74 V++ + +K G Sbjct: 85 VREDQTLKPG 94 >3H16-A nrPDB Length = 154 Score = 28.3 bits (62), Expect = 7.2, Method: Composition-based stats. Identities = 9/61 (14%), Positives = 21/61 (34%), Gaps = 2/61 (3%) Query: 156 YTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELK--LLQTIGKGEFGDVMLGD 213 + + A ++ A + +Y L+ + + +G FG V+L Sbjct: 24 FISHAWEDKADFVEALAHTLRAAGAEVWYDDFSLRPGDSLRRSIDKGLGSSRFGIVVLST 83 Query: 214 Y 214 + Sbjct: 84 H 84 >4DA5-A nrPDB Length = 457 Score = 27.9 bits (61), Expect = 8.1, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 31/104 (29%), Gaps = 25/104 (24%) Query: 272 GSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY------------LEGNN----FVHRDL 315 G++ YL+ R + +K + Y LE F H D Sbjct: 251 GTMEKYLKEVLRIKFTEESRIKKLHKLLS---YNLPLELENLRSLLESTPSPVVFCHNDC 307 Query: 316 AARNVLV------SEDNVAKVSDFGLTKEASSTQDTGKLPVKWT 353 N+L+ SE + DF + D G +W Sbjct: 308 QEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWM 351 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.153 0.461 Lambda K H 0.267 0.0466 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,447,254 Number of Sequences: 36641 Number of extensions: 909848 Number of successful extensions: 7280 Number of sequences better than 10.0: 655 Number of HSP's better than 10.0 without gapping: 1014 Number of HSP's successfully gapped in prelim test: 184 Number of HSP's that attempted gapping in prelim test: 2593 Number of HSP's gapped (non-prelim): 1358 length of query: 450 length of database: 10,336,785 effective HSP length: 100 effective length of query: 350 effective length of database: 6,672,685 effective search space: 2335439750 effective search space used: 2335439750 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (27.9 bits)