BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P32324 (842 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2P8Y-T nrPDB 1739 0.0 4V6W-Az nrPDB 1184 0.0 6MTD-v nrPDB 1123 0.0 6ID0-C nrPDB 609 e-174 3JB9-B nrPDB 535 e-152 5H7J-A nrPDB 421 e-118 5H7K-A nrPDB 202 5e-52 6NOT-A nrPDB 184 2e-46 4FN5-A nrPDB 171 1e-42 6N0I-A nrPDB 169 5e-42 4WQY-BZ nrPDB 134 2e-31 2YWH-A nrPDB 113 3e-25 3ZZ0-A nrPDB 113 3e-25 3CB4-D nrPDB 111 1e-24 5J8B-z nrPDB 108 9e-24 5A9Z-CA nrPDB 106 5e-23 5IMR-C nrPDB 103 2e-22 4V7D-BZ nrPDB 102 7e-22 6BK7-A nrPDB 102 9e-22 5TY0-A nrPDB 102 1e-21 5VH6-A nrPDB 95 2e-19 6B8D-A nrPDB 92 7e-19 2MZW-A nrPDB 90 5e-18 4V6V-A1 nrPDB 89 7e-18 1WDT-A nrPDB 86 7e-17 5KCS-1w nrPDB 85 1e-16 5TV2-A nrPDB 83 4e-16 3TR5-A nrPDB 74 2e-13 3VQT-A nrPDB 74 3e-13 4V89-AW nrPDB 64 2e-10 3WXM-A nrPDB 60 3e-09 1JNY-A nrPDB 58 2e-08 5W76-A nrPDB 57 3e-08 4AC9-A nrPDB 57 5e-08 4ZV4-A nrPDB 56 8e-08 5W75-A nrPDB 55 9e-08 4C0S-A nrPDB 55 1e-07 5LZS-jj nrPDB 55 1e-07 4J0Q-A nrPDB 54 2e-07 1D2E-A nrPDB 54 3e-07 5W7Q-A nrPDB 54 4e-07 3IZY-P nrPDB 52 1e-06 3MMP-A nrPDB 52 1e-06 6MIJ-A nrPDB 52 1e-06 2B7C-A nrPDB 52 2e-06 5YT0-A nrPDB 51 2e-06 6GB2-BC nrPDB 51 3e-06 2D74-A nrPDB 50 3e-06 5FG3-A nrPDB 50 3e-06 5LZY-jj nrPDB 50 4e-06 1MJ1-A nrPDB 49 6e-06 3MCA-A nrPDB 49 1e-05 4V5G-AZ nrPDB 49 1e-05 3WY9-A nrPDB 48 2e-05 4UJC-AB nrPDB 48 2e-05 4NCL-A nrPDB 48 2e-05 4N3G-A nrPDB 48 2e-05 1G7S-A nrPDB 48 2e-05 2LKD-A nrPDB 47 3e-05 5IZL-A nrPDB 47 4e-05 4ZU9-A nrPDB 46 7e-05 4TN1-B nrPDB 45 1e-04 3PEN-A nrPDB 45 1e-04 4B44-A nrPDB 44 2e-04 4KJZ-A nrPDB 44 2e-04 1EFM-A nrPDB 44 2e-04 1S0U-A nrPDB 44 2e-04 3J4J-A nrPDB 44 3e-04 3JCN-b nrPDB 41 0.002 3P27-A nrPDB 41 0.002 3IZQ-1 nrPDB 41 0.003 3WBI-A nrPDB 40 0.003 4V8Y-CP nrPDB 40 0.003 4NCF-A nrPDB 40 0.004 4V8Z-CV nrPDB 40 0.004 5LZD-z nrPDB 39 0.009 3J81-k nrPDB 39 0.009 1ZO1-I nrPDB 39 0.010 1ZUN-B nrPDB 39 0.010 6FEC-S nrPDB 38 0.021 6O81-S nrPDB 37 0.024 1R5O-A nrPDB 36 0.058 3JZY-A nrPDB 33 0.56 5LZT-jj nrPDB 33 0.72 4D61-i nrPDB 33 0.74 3E3X-A nrPDB 32 1.0 4CRN-P nrPDB 32 1.2 4ZCK-A nrPDB 32 1.4 2HDN-B nrPDB 31 2.6 5EG9-A nrPDB 30 3.0 4CB7-A nrPDB 30 3.1 >2P8Y-T nrPDB Length = 842 Score = 1739 bits (4504), Expect = 0.0, Method: Compositional matrix adjust. Identities = 842/842 (100%), Positives = 842/842 (100%) Query: 1 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTR 60 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTR Sbjct: 1 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTR 60 Query: 61 KDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALR 120 KDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALR Sbjct: 61 KDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALR 120 Query: 121 VTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR 180 VTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR Sbjct: 121 VTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR 180 Query: 181 TVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKM 240 TVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKM Sbjct: 181 TVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKM 240 Query: 241 MDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLL 300 MDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLL Sbjct: 241 MDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLL 300 Query: 301 EKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGP 360 EKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGP Sbjct: 301 EKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGP 360 Query: 361 ADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVP 420 ADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVP Sbjct: 361 ADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVP 420 Query: 421 GKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKV 480 GKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKV Sbjct: 421 GKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKV 480 Query: 481 MKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEI 540 MKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEI Sbjct: 481 MKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEI 540 Query: 541 CLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLA 600 CLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLA Sbjct: 541 CLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLA 600 Query: 601 IENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIK 660 IENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIK Sbjct: 601 IENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIK 660 Query: 661 DSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLA 720 DSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLA Sbjct: 661 DSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLA 720 Query: 721 DPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGF 780 DPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGF Sbjct: 721 DPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGF 780 Query: 781 TGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYD 840 TGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYD Sbjct: 781 TGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYD 840 Query: 841 KL 842 KL Sbjct: 841 KL 842 >4V6W-Az nrPDB Length = 844 Score = 1184 bits (3063), Expect = 0.0, Method: Compositional matrix adjust. Identities = 568/848 (66%), Positives = 685/848 (80%), Gaps = 10/848 (1%) Query: 1 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTR 60 MV FTVD++R LMDK N+RNMSVIAHVDHGKSTLTDSLV +AGII+ AKAGE RFTDTR Sbjct: 1 MVNFTVDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTR 60 Query: 61 KDEQERGITIKSTAISLYSEMSDEDVKEI----KQKTDGNSFLINLIDSPGHVDFSSEVT 116 KDEQER ITIKSTAIS+Y E+ ++D+ I +++ + FLINLIDSPGHVDFSSEVT Sbjct: 61 KDEQERCITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVT 120 Query: 117 AALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 AALRVTDGALVVVD + GVCVQTETVLRQA+ ERIKP++ +NK+DRALLELQ+ E+LYQ Sbjct: 121 AALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQ 180 Query: 177 TFARTVESVNVIVSTYADE--VLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFG 234 TF R VE+VNVI++TY D+ +G+V+V P++G+V FGSGLHGWAFT++QF+ Y++KF Sbjct: 181 TFQRIVENVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKFK 240 Query: 235 VDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKD 294 +D K+M+RLWG++FFN KTKKW K +A+ K R+F M+ILDPI+++F AIMN+KK+ Sbjct: 241 IDVVKLMNRLWGENFFNAKTKKW-QKQKEADNK---RSFCMYILDPIYKVFDAIMNYKKE 296 Query: 295 EIPVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAE 354 EI LLEK+ + LK ++KD +GKALLK VMR +LPA +ALL+MI +HLPSPV AQ YR E Sbjct: 297 EIGTLLEKIGVTLKHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRME 356 Query: 355 QLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQ 414 LYEGP DD IA+K+CDP LM+Y+SKMVPTSDKGRFYAFGRVFAG V +GQK RI Sbjct: 357 MLYEGPHDDEAAIAVKSCDPDGPLMMYISKMVPTSDKGRFYAFGRVFAGKVATGQKCRIM 416 Query: 415 GPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSET 474 GPNY PGKK+DL+ KAIQR +LMMGR+VE I+D P+GNI GLVG+DQFL+KTGT+TT + Sbjct: 417 GPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKD 476 Query: 475 AHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTG 534 AHNMKVMKFSVSPVV+VAVE KN DLPKLVEGLKRL+KSDP V + ESGEHI+AG G Sbjct: 477 AHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAG 536 Query: 535 ELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPID 594 ELHLEICL+DLE DHA +PLK S PVV+YRETV ES Q LSKSPNKHNR+ +KA P+ Sbjct: 537 ELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLSKSPNKHNRLLMKALPMP 596 Query: 595 EEVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQ 654 + + I+NG ++ +D+FKARAR +++ Y +DVT+ARKIWCFGPDG GPN ++D TK+VQ Sbjct: 597 DGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGPDGTGPNFILDCTKSVQ 656 Query: 655 YLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATY 714 YL+EIKDSVVA FQWA+KEG + E +R VR NI DVTLHADAIHRGGGQIIPT RR Y Sbjct: 657 YLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIHRGGGQIIPTTRRCLY 716 Query: 715 AGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPV 774 A + A P++ EPV+L EIQCPE AVGGIY VLN++RG V E Q GTP+F VKAYLPV Sbjct: 717 AAAITAKPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKAYLPV 776 Query: 775 NESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPG 834 NESFGFT +LR TGGQAFPQ VFDHW L DP +P+SK IV RKR G+KE +P Sbjct: 777 NESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPSEPSSKPYAIVQDTRKRKGLKEGLPD 836 Query: 835 WQEYYDKL 842 +Y DKL Sbjct: 837 LSQYLDKL 844 >6MTD-v nrPDB Length = 839 Score = 1123 bits (2906), Expect = 0.0, Method: Compositional matrix adjust. Identities = 552/857 (64%), Positives = 655/857 (76%), Gaps = 34/857 (3%) Query: 2 VAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRK 61 V FTVDQ+R++MDK N+RNMSVIAHVDHGKSTLTDSLV +AGII+ Sbjct: 1 VNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIA-------------- 46 Query: 62 DEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRV 121 R ITIKSTAISL+ E+S+ D+ IKQ DG FLINLIDSPGHVDFSSEVTAALRV Sbjct: 47 ----RCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRV 102 Query: 122 TDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFART 181 TDGALVVVD + GVCVQTETVLRQA+ ERIKPV+++NK+DRALLELQ+ E+LYQTF R Sbjct: 103 TDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRI 162 Query: 182 VESVNVIVSTYADE---VLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGV--- 235 VE+VNVI+STY + +G++ + P GTV FGSGLHGWAFT++QFA Y KF Sbjct: 163 VENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGE 222 Query: 236 ------DKAK----MMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLF 285 ++AK MM +LWGD +F+P K++ T EGK L R F ILDPIF++F Sbjct: 223 GQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVF 282 Query: 286 TAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSP 345 AIMNFKK+E L+EKL+I L ++KD EGK LLK VMR++LPA DALL+MI +HLPSP Sbjct: 283 DAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSP 342 Query: 346 VTAQAYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTV 405 VTAQ YR E LYEGP DD + IK+CDPK LM+Y+SKMVPTSDKGRFYAFGRVF+G V Sbjct: 343 VTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLV 402 Query: 406 KSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLK 465 +G KVRI GPNY PGKK+DL++K IQR +LMMGR+VEPI+D P GNI+GLVG+DQFL+K Sbjct: 403 STGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVK 462 Query: 466 TGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSES 525 TGT+TT E AHNM+VMKFSVSPVV+VAVE KN DLPKLVEGLKRL+KSDP V + ES Sbjct: 463 TGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEES 522 Query: 526 GEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNR 585 GEHI+AG GELHLEICL+DLE DHA +P+K S PVV+YRETV ES+ LSKSPNKHNR Sbjct: 523 GEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNR 582 Query: 586 IYLKAEPIDEEVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNL 645 +Y+KA P + ++ I+ G ++ R + K RAR +A+ Y WDV +ARKIWCFGPDG GPN+ Sbjct: 583 LYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNI 642 Query: 646 VIDQTKAVQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQI 705 + D TK VQYL+EIKDSVVA FQWATKEG + E MR VR ++ DVTLHADAIHRGGGQI Sbjct: 643 LTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQI 702 Query: 706 IPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPL 765 IPT RR YA L A P++ EP++LVEIQCPEQ VGGIY VLN+KRG V E Q GTP+ Sbjct: 703 IPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPM 762 Query: 766 FTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKR 825 F VKAYLPVNESFGFT +LR TGGQAFPQ VFDHW L DP D +S+ ++V RKR Sbjct: 763 FVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKR 822 Query: 826 HGMKEEVPGWQEYYDKL 842 G+KE +P + DKL Sbjct: 823 KGLKEGIPALDNFLDKL 839 >6ID0-C nrPDB Length = 972 Score = 609 bits (1571), Expect = e-174, Method: Compositional matrix adjust. Identities = 313/853 (36%), Positives = 500/853 (58%), Gaps = 37/853 (4%) Query: 1 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGI-ISAAKAGEARFTDT 59 + + +D + LMD +RN+++ H+ HGK+ D L+++ I + +TD Sbjct: 111 VTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDI 170 Query: 60 RKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAAL 119 EQERG+ IKST +++ + T G S+L N++D+PGHV+FS EVTA L Sbjct: 171 LFTEQERGVGIKSTPVTV-----------VLPDTKGKSYLFNIMDTPGHVNFSDEVTAGL 219 Query: 120 RVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFA 179 R++DG ++ +D EGV + TE +++ A+ ER+ V INK+DR +LEL++ D Y Sbjct: 220 RISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLR 279 Query: 180 RTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFG-VDKA 238 V+ VN ++S Y+ + ++ + P G V F S + FT+ FA YA FG ++ Sbjct: 280 HIVDEVNGLISMYSTD--ENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQ 337 Query: 239 KMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPV 298 + RLWGD +FNPKT+K+T K A +R+F FIL+P++++ ++ +P Sbjct: 338 EFAKRLWGDIYFNPKTRKFTKK---APTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPR 394 Query: 299 LLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYE 358 L++L I L +E L + LL++V +KF ++M V H+PSP + E Y Sbjct: 395 TLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYT 454 Query: 359 GPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNY 418 G D A+ +CDP LM + +KM T D +F+AFGRV +GT+ +GQ V++ G NY Sbjct: 455 GGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENY 514 Query: 419 VPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTT---SETA 475 ++D I + R+ + + R+ ++ PAGN + + G+DQ ++KT T+T +E A Sbjct: 515 TLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEA 574 Query: 476 HNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGE 535 + +KF+ + V+++AVE N ++LPK+++GL++++KS P + T + ESGEH++ GTGE Sbjct: 575 QIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGE 634 Query: 536 LHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDE 595 L+L+ + DL ++ + +K++ PVV + ETV SS +++PNK N+I + AEP+++ Sbjct: 635 LYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEK 694 Query: 596 EVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQ- 654 ++ IEN ++ + K Y WD+ AR IW FGPD GPN+++D T + Sbjct: 695 GLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEV 754 Query: 655 ---YLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRR 711 L +KDS+V FQW T+EGP+ E +R+V+ ILD + + +HRGGGQIIPT RR Sbjct: 755 DKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARR 814 Query: 712 ATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAY 771 Y+ FL+A P++ EP + VE+Q P V +Y+VL ++RG V + PG+PL+T+KA+ Sbjct: 815 VVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAF 874 Query: 772 LPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPT------------SKAGEIV 819 +P +SFGF +LR T GQAF VF HW + DPLD + A E + Sbjct: 875 IPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFM 934 Query: 820 LAARKRHGMKEEV 832 + R+R G+ E+V Sbjct: 935 IKTRRRKGLSEDV 947 >3JB9-B nrPDB Length = 984 Score = 535 bits (1379), Expect = e-152, Method: Compositional matrix adjust. Identities = 304/857 (35%), Positives = 476/857 (55%), Gaps = 48/857 (5%) Query: 12 LMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGI-ISAAKAGEARFTDTRKDEQERGITI 70 L+ +VR+ V H+ HGKS L D LV K R+TDT E+ER ++I Sbjct: 134 LLTGTDDVRSFIVAGHLHHGKSALLDLLVYYTHPDTKPPKRRSLRYTDTHYLERERVMSI 193 Query: 71 KSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130 KST ++L V ++K G +F ID+PGHVDF EV A + ++DG ++VVD Sbjct: 194 KSTPLTLA-------VSDMK----GKTFAFQCIDTPGHVDFVDEVAAPMAISDGVVLVVD 242 Query: 131 TIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVS 190 IEGV + T +++ A+ + V+V+NKVDR +LEL++ D Y ++ VN + Sbjct: 243 VIEGVMINTTRIIKHAILHDMPIVLVLNKVDRLILELRLPPNDAYHKLRHVIDEVNDNIC 302 Query: 191 TYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFG-VDKAKMMDRLWGDSF 249 + ++ +V P G V F S G+ FT+ FA Y + G +D RLWGD + Sbjct: 303 QISKDL--KYRVSPELGNVCFASCDLGYCFTLSSFAKLYIDRHGGIDVDLFSKRLWGDIY 360 Query: 250 FNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKG 309 F+ KT+K+ + D G R+F FIL+P+++L T ++ + +++ L +I LK Sbjct: 361 FDSKTRKFAKQSLDGSGV---RSFVHFILEPLYKLHTLTISDEAEKLKKHLSSFQIYLKP 417 Query: 310 DEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAI 369 + L+ K LL+++ F + + H+PSP A +A Q Y GP + + AI Sbjct: 418 KDYLLDPKPLLQLICASFFGFPVGFVNAVTRHIPSPRENAARKASQSYIGPINSSIGKAI 477 Query: 370 KNC--DPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLF 427 + A L+++V+K+ T D FYAF RV++G VK GQKV++ G NY ++D+ Sbjct: 478 LEMSREESAPLVMHVTKLYNTVDANNFYAFARVYSGQVKKGQKVKVLGENYSLEDEEDMV 537 Query: 428 IKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSP 487 + I + + R+ +D AG ++ L G+D + KT T+ + N+K + P Sbjct: 538 VAHIAEICVPCARYRLHVDGAVAGMLVLLGGVDNSISKTATIVSD----NLKDDPYIFRP 593 Query: 488 -------VVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEI 540 V +VAVE N ++LPKL++GL++ +KS P +T + ESGEH + GTGE++++ Sbjct: 594 IAHMSESVFKVAVEPHNPSELPKLLDGLRKTNKSYPLSITKVEESGEHTIFGTGEMYMDC 653 Query: 541 CLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLA 600 L DL ++ + +++S PV + ET SS S +PNK NRI + EP+++ +S Sbjct: 654 LLYDLRTLYSEIEIRVSDPVARFCETAVDTSSIKCFSDTPNKKNRITMVVEPLEKGISND 713 Query: 601 IENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAV----QYL 656 IENG +N K + +Y WD+ +R IW FGPD G N++ D T + L Sbjct: 714 IENGKVNINWPQKRISEFFQKNYDWDLLASRSIWAFGPDDRGTNILRDDTLSTDVDKNVL 773 Query: 657 HEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAG 716 + +K+ + FQW T+EGP+ E +R+V ++DV L + I+RGGGQIIPT RR Y+ Sbjct: 774 NSVKEYIKQGFQWGTREGPLCDETIRNVNFRLMDVVLAPEQIYRGGGQIIPTARRVCYSS 833 Query: 717 FLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNE 776 FL A P++ EPV++VE+ P ++ IY +L ++RG V+ + RPG+PL+ V+A +PV + Sbjct: 834 FLTASPRLMEPVYMVEVHAPADSLPIIYDLLTRRRGHVLQDIPRPGSPLYLVRALIPVID 893 Query: 777 SFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSK------------AGEIVLAARK 824 S GF +LR T GQA QMVFDHW + DPLD + K A + ++ R+ Sbjct: 894 SCGFETDLRVHTQGQAMCQMVFDHWQVVPGDPLDKSIKPKPLEPARGSDLARDFLIKTRR 953 Query: 825 RHGMKEEVPGWQEYYDK 841 R G+ E+V Y+D+ Sbjct: 954 RKGLVEDV-STTRYFDQ 969 >5H7J-A nrPDB Length = 743 Score = 421 bits (1083), Expect = e-118, Method: Compositional matrix adjust. Identities = 277/805 (34%), Positives = 413/805 (51%), Gaps = 127/805 (15%) Query: 6 VDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQE 65 + +++ LM + +RN+ + AH+DHGK+TL+D+L+ AG+IS AG+ D + EQ Sbjct: 11 IAKIKELMLQPERIRNIGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQLVLDFDEQEQA 70 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RGITI + +S+ +G +LINLID+PGHVDF +VT A+R DG Sbjct: 71 RGITINAANVSMV------------HNYEGKDYLINLIDTPGHVDFGGDVTRAMRAIDGV 118 Query: 126 LVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESV 185 ++VVD +EGV QTETV+RQAL E +KPV+ INKVDR + EL+ Sbjct: 119 IIVVDAVEGVMPQTETVVRQALREYVKPVLFINKVDRLIRELK----------------- 161 Query: 186 NVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLW 245 T +Q R++K +D +++ R Sbjct: 162 ----------------------------------LTPQQMMERFSKII-MDVNRLIQRYA 186 Query: 246 GDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEI 305 + + KKW K D +N + P + N E +++ Sbjct: 187 PEEY----KKKWMVKVEDGSVAFGSAYYNWALSVPFMKRTGVKFN----------EIIDL 232 Query: 306 VLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDAN 365 LKGD + L KA L VV +L+M+V HLPSP+ AQ YR L+EG Sbjct: 233 TLKGDNRTLRQKAPLHVV----------VLDMVVRHLPSPIEAQKYRIPHLWEGDISSDI 282 Query: 366 CIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDD 425 A+ NCDPK +++ V+K++ G A GRV++GTVKSGQ+V Y+ K Sbjct: 283 GQAMLNCDPKGKMVMVVTKIIIDKHAGEV-ATGRVWSGTVKSGQEV------YLINTKRK 335 Query: 426 LFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSV 485 IQ+V + MG ++ PAGNI+ + G+ + G E + + + Sbjct: 336 ---ARIQQVGIYMGPERINMEAVPAGNIVAVTGLRDAM--AGETVAEEQIEPFEALHYVS 390 Query: 486 SPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQD 544 PVV VA+E KN DLP+L+E L++L+K DP + + E+G+H+++G GELHLE+ L Sbjct: 391 EPVVTVAIEAKNVKDLPRLIEALRQLAKEDPTLHVKIDEETGQHLLSGMGELHLEVKLYK 450 Query: 545 LEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENG 604 L+ D G+ +++S P+V YRE++ ++SS KSPN+HNR Y+ EP+ +E+ AI+ G Sbjct: 451 LKKDW-GIDIEVSEPIVVYRESI-TKSSPMVEGKSPNRHNRFYIVVEPMPDEIYNAIKEG 508 Query: 605 II------NPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHE 658 II NP++ K A + G D AR I D N+ ID TK VQYL+E Sbjct: 509 IIPEGRVKNPKEVAKKLAEL-----GMDYEIARGIV----DIYNGNMFIDNTKGVQYLNE 559 Query: 659 IKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFL 718 + D ++ F A EGP+ E + V V +LD +H D +HRG QI P +R A + + Sbjct: 560 VMDLLIDGFHQAMDEGPLAREPVMKVIVRLLDAQVHEDNVHRGPAQIYPAIRTAIHCAMM 619 Query: 719 LADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESF 778 ++P + EP V I P + +G + + ++RGQ+V +Q + T+ A PV E F Sbjct: 620 KSNPVLYEPYQKVIINIPYEYMGAVSREITQRRGQLVDMKQE--GEVMTIIAEAPVAEMF 677 Query: 779 GFTGELRQATGGQAFPQMVFDHWST 803 GF G +R AT G+A WST Sbjct: 678 GFAGSIRSATSGRAL-------WST 695 >5H7K-A nrPDB Length = 397 Score = 202 bits (514), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 146/455 (32%), Positives = 226/455 (49%), Gaps = 100/455 (21%) Query: 6 VDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQE 65 + +++ LM + +RN+ + AH+DHGK+TL+D+L+ AG+IS AG+ D + EQ Sbjct: 11 IAKIKELMLQPERIRNIGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQLVLDFDEQEQA 70 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RGITI + +S+ +G +LINLID+PGHVDF +VT A+R DG Sbjct: 71 RGITINAANVSMV------------HNYEGKDYLINLIDTPGHVDFGGDVTRAMRAIDGV 118 Query: 126 LVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESV 185 ++VVD +EGV QTETV+RQAL E +KPV+ INKVDR + EL+++ + + + F++ + V Sbjct: 119 IIVVDAVEGVMPQTETVVRQALREYVKPVLFINKVDRLIRELKLTPQQMMERFSKIIMDV 178 Query: 186 NVIVSTYA-DEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRL 244 N ++ YA +E V G+VAFGS + WA ++ + K+ GV +++D Sbjct: 179 NRLIQRYAPEEYKKKWMVKVEDGSVAFGSAYYNWALSV-----PFMKRTGVKFNEIIDL- 232 Query: 245 WGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLE 304 T K N+ T + PL ++ +LD + R + + +K IP L E Sbjct: 233 ---------TLKGDNR-TLRQKAPL----HVVVLDMVVRHLPSPIEAQKYRIPHLWE--- 275 Query: 305 IVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDA 364 GD G+A+L Sbjct: 276 ----GDISSDIGQAML-------------------------------------------- 287 Query: 365 NCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKD 424 NCDPK +++ V+K++ G A GRV++GTVKSGQ+V Y+ K Sbjct: 288 ------NCDPKGKMVMVVTKIIIDKHAGEV-ATGRVWSGTVKSGQEV------YLINTKR 334 Query: 425 DLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGI 459 IQ+V + MG ++ PAGNI+ + G+ Sbjct: 335 K---ARIQQVGIYMGPERINMEAVPAGNIVAVTGL 366 >6NOT-A nrPDB Length = 707 Score = 184 bits (466), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 209/815 (25%), Positives = 348/815 (42%), Gaps = 138/815 (16%) Query: 11 SLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEAR----FTDTRKDEQER 66 S ++K+ +RN+ + AH+D GK+T T+ ++ G + K GE D + EQER Sbjct: 10 SKINKLEQIRNIGICAHIDAGKTTTTERILYYTG--KSHKIGEVHEGGATMDWMEQEQER 67 Query: 67 GITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGAL 126 GITI S A + + +IN+ID+PGHVDF+ EV +LRV DGA+ Sbjct: 68 GITITSAATTCRWQ----------------DKVINIIDTPGHVDFTIEVERSLRVLDGAV 111 Query: 127 VVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVN 186 V D + GV Q+ETV RQA + + +NK+DR + F R VE + Sbjct: 112 AVFDGVAGVEPQSETVWRQADKYNVPRMCFVNKMDR-----------MGADFYRCVEMIK 160 Query: 187 VIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFG--VDKAKMMDRL 244 + LG AR + Q + F V+ KM + Sbjct: 161 --------DRLG------ARSLII-------------QLPIGIEENFKGIVNLIKMKAVI 193 Query: 245 WGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLE 304 W D ++ +D A+ + + +LD + L IM + E+++ Sbjct: 194 WKDESLGA---EYFEEDIPADMQDKAAEYRARLLDMVVELDDTIMEQYLSGAEITEEQIK 250 Query: 305 IVLKGDEKDLEGKALLKVVMRKFL-PAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADD 363 I+++ + +E + + F LL+ IV LPSP+ + ++ D Sbjct: 251 ILIR--KGTIEARFYPILCGSAFKNKGVQPLLDAIVDFLPSPIDIGIVKGIEVSTSEEKD 308 Query: 364 ANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKK 423 I +P + L K++ G F R+++G + SG V N V K+ Sbjct: 309 ---FPISIVEPFSALAF---KIMNDPFVGSL-TFIRIYSGKITSGATV----INTVKNKR 357 Query: 424 DDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTG-TLTTSETAHNMKVMK 482 + I R++LM E I + AG+I+ L G+ TG TL+ + ++ M+ Sbjct: 358 E-----KIGRMLLMHANNREDIKEASAGDIVALAGLKD--TSTGDTLSDIDKQVVLERME 410 Query: 483 FSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCV-LTYMSESGEHIVAGTGELHLEIC 541 F PV+++AVE K+ D K+ L RL+ DP ++ E+G+ ++ G GELHLEI Sbjct: 411 FP-EPVIELAVEPKSTADQEKMGLALSRLAAEDPSFRVSTDHETGQTVIKGMGELHLEII 469 Query: 542 LQDLEHDHAGVPLKISPPVVAYRETV----ESESSQTALSKSPNKHNRIYLKAEPIDEEV 597 + + + V I P VAYRET+ E + + S + R+ + EP+ + + Sbjct: 470 IDRMRREFK-VEANIGAPQVAYRETITTACEIDYTHKKQSGGAGQFARVKIIFEPLKDVI 528 Query: 598 SLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQY-L 656 L E D K + F G + + V+ L Sbjct: 529 DLKDE--------------------------DKNKTFVFESKIVGGAVPKEYIPGVEKGL 562 Query: 657 HEIKDS-VVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYA 715 + I+++ V+A + + + V ++L + A R G Q Sbjct: 563 NNIRETGVIAGYPMIDFKATLVDGAFHDVDSSVLAFEIAAKGAFREGMQ----------- 611 Query: 716 GFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVN 775 +PK+ EP+ VE+ P++ +G I LN +RGQ+ + + R + T A++P+ Sbjct: 612 ---KGNPKLLEPIMKVEVITPDEYMGDIIGDLNSRRGQIQNMDPRGNAQVVT--AHVPLA 666 Query: 776 ESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLD 810 E FG+ LR + G+A M+F H+ + S D Sbjct: 667 EMFGYVNTLRSLSQGRAQFSMIFSHYDQVPSQVAD 701 >4FN5-A nrPDB Length = 709 Score = 171 bits (433), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 210/822 (25%), Positives = 345/822 (41%), Gaps = 148/822 (18%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ + AHVD GK+T T+ ++ G+ K GE A TD EQERGITI Sbjct: 10 INRYRNIGICAHVDAGKTTTTERVLFYTGV--NHKLGEVHDGAATTDWMVQEQERGITIT 67 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 S A++ + + S + +++ +N+ID+PGHVDF+ EV +LRV DGA+VV Sbjct: 68 SAAVTTFWKGS---------RGQYDNYRVNVIDTPGHVDFTIEVERSLRVLDGAVVVFCG 118 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 GV Q+ETV RQA + +V +NK+DR F R VE + Sbjct: 119 TSGVEPQSETVWRQANKYGVPRIVYVNKMDRQ-----------GANFLRVVEQIK----- 162 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 + LG V P + + G VD KM W D + Sbjct: 163 ---KRLGHTPV-PVQLAIGAEENFVGQ----------------VDLIKMKAIYWND---D 199 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 K + ++ AE K L + +++ +MN LE+ E+ E Sbjct: 200 DKGMTYREEEIPAELKDLAEEWRSSMVEAAAEANEELMN-------KYLEEGEL----SE 248 Query: 312 KDLEGKALLKVVMRKFLPAADA----------LLEMIVLHLPSPVTAQAYRAEQLYEGPA 361 +++ L+ + + +PA +L+ ++ +LP+P A + Sbjct: 249 AEIKEGLRLRTLACEIVPAVCGSSFKNKGVPLVLDAVIDYLPAPTEIPAIKGVS-----P 303 Query: 362 DDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPG 421 DD ++ D K+ G F RV++G + SG V N V G Sbjct: 304 DDETVEDERHADDNEPFSSLAFKIATDPFVGTL-TFARVYSGVLSSGDSVL----NSVKG 358 Query: 422 KKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTG-TLTTSETAHNMKV 480 KK+ + R+V M E I + AG+I L+G+ + TG TL + E ++ Sbjct: 359 KKE-----RVGRMVQMHANQREEIKEVRAGDIAALIGMKD--VTTGDTLCSIEKPIILER 411 Query: 481 MKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLE 539 M F PV+ VAVE K D K+ L +L++ DP ESG+ I++G GELHL+ Sbjct: 412 MDFP-EPVISVAVEPKTKADQEKMGIALGKLAQEDPSFRVKTDEESGQTIISGMGELHLD 470 Query: 540 ICLQDLEHDHAGVPLKISPPVVAYRET-------VESESSQTALSKSPNKHNRIYLKAEP 592 I + ++ + GV I P VAYRET +E + + + + H I A Sbjct: 471 IIVDRMKREF-GVEANIGKPQVAYRETITKDNVEIEGKFVRQSGGRGQFGHCWIRFSAAD 529 Query: 593 IDEEVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKA 652 +DE+ + I G++ F+ N V+ Sbjct: 530 VDEKGN--ITEGLV-----FE------------------------------NEVVGGVVP 552 Query: 653 VQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRA 712 +Y+ I+ + + K G + G + ++ + D + H + +I +M A Sbjct: 553 KEYIPAIQKGI----EEQMKNGVVAGYPLIGLKATVFDGSYHDVDSNEMAFKIAASM--A 606 Query: 713 TYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYL 772 T K+ EP+ VE+ PE +G + LN++RG + E + ++A + Sbjct: 607 TKQLAQKGGGKVLEPIMKVEVVTPEDYMGDVMGDLNRRRGLIQGMEDTVSGKV--IRAEV 664 Query: 773 PVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSK 814 P+ E FG+ ++R + G+A M F ++ S+ ++ K Sbjct: 665 PLGEMFGYATDVRSMSQGRASYSMEFSKYAEAPSNIVEALVK 706 >6N0I-A nrPDB Length = 706 Score = 169 bits (427), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 212/825 (25%), Positives = 344/825 (41%), Gaps = 155/825 (18%) Query: 20 RNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIKSTAI 75 RN+ ++AHVD GK+T T+ ++ G+ K GE A D EQERGITI S A Sbjct: 14 RNIGIVAHVDAGKTTTTERILFYTGV--NHKMGEVHDGAATMDWMAQEQERGITITSAAT 71 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 + + + S K + + N+ID+PGHVDF+ EV +LRV DGA+VV +GV Sbjct: 72 TAFWQGS--------TKQFAHKYRFNIIDTPGHVDFTIEVERSLRVLDGAVVVFSGADGV 123 Query: 136 CVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADE 195 Q+ETV RQA + + INK+DR + F R V+ + D+ Sbjct: 124 EPQSETVWRQANKYHVPRLAYINKMDRQGAD-----------FLRVVKQI--------DQ 164 Query: 196 VLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTK 255 LG +P +A GS F + +D KM W D+ + Sbjct: 165 RLGH---HPVPIQLAIGSE--------ENFMGQ------IDLVKMKAIYWNDA---DQGT 204 Query: 256 KWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPV-LLEKLEIVLKGDEKDL 314 + ++ AE K L + +++ DE+ + L+ E+ ++ + L Sbjct: 205 SYREEEIPAELKALADEWRAHMIEAAAE--------ANDELTMKFLDGEELSIEEIKAGL 256 Query: 315 EGKALLKVVMRKFLPAA------DALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIA 368 + + ++ L ++ +L+ ++ +LP+P A R P D+ + Sbjct: 257 RQRTIANEIVPTILGSSFKNKGVPLMLDAVIDYLPAPSEIPAIRGTD----PDDEEKHLE 312 Query: 369 IKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFI 428 ++ D K K+ G F RV++G + SG V N V GKK+ Sbjct: 313 -RHADDKEPFSALAFKIATDPFVGTL-TFARVYSGVLSSGNAVL----NSVKGKKE---- 362 Query: 429 KAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTG-TLTTSETAHNMKVMKFSVSP 487 I R+V M I D AG+I L+G+ + TG TL + ++ M F P Sbjct: 363 -RIGRMVQMHANQRAEIKDVCAGDIAALIGMKD--VTTGDTLCDMDKPIILERMDFP-DP 418 Query: 488 VVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQDLE 546 V+ VAVE K D K+ L +L++ DP E+G+ I++G GELHL+I + + Sbjct: 419 VISVAVEPKTKADQEKMGIALGKLAQEDPSFRVRTDEETGQTIISGMGELHLDIIVDRMR 478 Query: 547 HDHAGVPLKISPPVVAYRE----TVESESSQTALSKSPNKHNRIYLKAEPIDE-EVSLAI 601 + V I P VAYRE T E E S ++ +++ P DE + L Sbjct: 479 REF-NVEANIGKPQVAYREKIRNTCEIEGRFVRQSGGRGQYGHCWIRFAPGDEGKEGLEF 537 Query: 602 ENGIIN---PRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHE 658 N I+ PR+ A + + + + Sbjct: 538 INEIVGGVVPREYIPAIQKGIEE------------------------------------Q 561 Query: 659 IKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFL 718 +K+ V+A + + +F V N + + A + T + + G + Sbjct: 562 MKNGVLAGYPLINLKAAVFDGSYHDVDSNEMAYKIAAS---------MATKQLSQKGGAV 612 Query: 719 LADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESF 778 L EPV VE+ PE+ G I L+++RG + ++ P + ++A +P+ E F Sbjct: 613 LL-----EPVMKVEVVTPEEYQGDILGDLSRRRGMIQDGDETPAGKV--IRAEVPLGEMF 665 Query: 779 GFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAAR 823 G+ +R T G+A M F ++ P S A IV +R Sbjct: 666 GYATSMRSMTQGRASFSMEFTRYAEA------PASIADGIVKKSR 704 >4WQY-BZ nrPDB Length = 758 Score = 134 bits (337), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 121/471 (25%), Positives = 207/471 (43%), Gaps = 67/471 (14%) Query: 334 LLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGR 393 LL+ +V +LPSP+ + G + + I + DP L K++ GR Sbjct: 339 LLDAVVDYLPSPLDIPPIK------GTTPEGEVVEI-HPDPNGPLAALAFKIMADPYVGR 391 Query: 394 FYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNI 453 F RV++GT+ SG V N G+K+ + R++ M E +++ AG++ Sbjct: 392 L-TFIRVYSGTLTSGSYVY----NTTKGRKE-----RVARLLRMHANHREEVEELKAGDL 441 Query: 454 IGLVGIDQFLLKTGTLTTSETAHNMKVMKFSV-SPVVQVAVEVKNANDLPKLVEGLKRLS 512 +VG+ + + TG E A + + V PV+ VA+E K D KL + L RL+ Sbjct: 442 GAVVGLKETI--TGDTLVGEDAPRVILESIEVPEPVIDVAIEPKTKADQEKLSQALARLA 499 Query: 513 KSDPCV-LTYMSESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESES 571 + DP ++ E+G+ I++G GELHLEI + L+ + V + P VAYRET+ Sbjct: 500 EEDPTFRVSTHPETGQTIISGMGELHLEIIVDRLKREFK-VDANVGKPQVAYRETI---- 554 Query: 572 SQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARARIMADDYGWDVTDAR 631 +P+D E + G K + + G++ +A Sbjct: 555 ------------------TKPVDVEGKFIRQTGGRGQYGHVKIKVEPLPRGSGFEFVNA- 595 Query: 632 KIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDV 691 ++ +Y+ ++ + A Q GP+ G + ++V + D Sbjct: 596 --------------IVGGVIPKEYIPAVQKGIEEAMQ----SGPLIGFPVVDIKVTLYDG 637 Query: 692 TLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKR 751 + H +I +M A DP I EP+ VE+ PE+ +G + LN +R Sbjct: 638 SYHEVDSSEMAFKIAGSM--AIKEAVQKGDPVILEPIMRVEVTTPEEYMGDVIGDLNARR 695 Query: 752 GQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWS 802 GQ++ E R + ++A++P+ E FG+ +LR T G+ M FDH+ Sbjct: 696 GQILGMEPRGNAQV--IRAFVPLAEMFGYATDLRSKTQGRGSFVMFFDHYQ 744 Score = 94.0 bits (232), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 110/217 (50%), Gaps = 45/217 (20%) Query: 12 LMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERG 67 L + + +RN+ + AH+D GK+T T+ ++ G I K GE A D + E+ERG Sbjct: 72 LENDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIH--KIGEVHEGAATMDFMEQERERG 129 Query: 68 ITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALV 127 ITI + + + + IN+ID+PGHVDF+ EV ++RV DGA+V Sbjct: 130 ITITAAVTTCFWK----------------DHRINIIDTPGHVDFTIEVERSMRVLDGAIV 173 Query: 128 VVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRA--------------------LLEL 167 V D+ +GV Q+ETV RQA ++ + NK+D+ +++L Sbjct: 174 VFDSSQGVEPQSETVWRQAEKYKVPRIAFANKMDKTGADLWLVIRTMQERLGARPVVMQL 233 Query: 168 QVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYP 204 + +ED TF+ ++ + + TY +++ D++ P Sbjct: 234 PIGRED---TFSGIIDVLRMKAYTYGNDLGTDIREIP 267 >2YWH-A nrPDB Length = 600 Score = 113 bits (283), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 61/144 (42%), Positives = 90/144 (62%), Gaps = 12/144 (8%) Query: 18 NVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISL 77 NVRN +IAHVDHGKSTL D L++ G IS + E + DT E+ERGIT+K A+ + Sbjct: 5 NVRNFCIIAHVDHGKSTLADRLLEYTGAISEREKRE-QLLDTLDVERERGITVKMQAVRM 63 Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 + + D GN++ ++LID+PGHVDFS EV+ AL +GAL+++D +G+ Sbjct: 64 FYKAKD-----------GNTYKLHLIDTPGHVDFSYEVSRALAACEGALLLIDASQGIEA 112 Query: 138 QTETVLRQALGERIKPVVVINKVD 161 QT +A+ + + + VINK+D Sbjct: 113 QTVANFWKAVEQDLVIIPVINKID 136 Score = 29.6 bits (65), Expect = 6.4, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 21/178 (11%) Query: 396 AFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNI-- 453 AF R+F G VK G K+ + GK+ + + + M +F D AG++ Sbjct: 210 AFVRIFDGEVKPGDKIMLMS----TGKEYE--VTEVGAQTPKMTKF----DKLSAGDVGY 259 Query: 454 IGLVGIDQFLLKTG-TLTTSETAHNMKVMKFS-VSPVVQVAVEVKNANDLPKLVEGLKRL 511 I D ++ G T+T ++ V F P+V + +L + L++ Sbjct: 260 IAASIKDVRDIRIGDTITHAKNPTKEPVPGFQPAKPMVYAGIYPAEDTTYEELRDALEKY 319 Query: 512 SKSDPCVLTYMSESGEHIVAG-----TGELHLEICLQDLEHDHAGVPLKISPPVVAYR 564 + +D ++ Y ES + G G LH+EI + LE ++ GV + + P V YR Sbjct: 320 AINDAAIV-YEPESSPALGMGFRVGFLGLLHMEIVQERLEREY-GVKIITTAPNVIYR 375 >3ZZ0-A nrPDB Length = 693 Score = 113 bits (283), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 124/500 (24%), Positives = 212/500 (42%), Gaps = 96/500 (19%) Query: 334 LLEMIVLHLPSPVTAQ---AYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSD 390 +L+ ++ +LPSP+ + +RA P ++ I D A+ K++ Sbjct: 270 MLDAVIDYLPSPLDVKPIIGHRASN----PEEEV----IAKADDSAEFAALAFKVMTDPY 321 Query: 391 KGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPA 450 G+ F RV++GT+ SG V+ N GK++ + R++ M + ID + Sbjct: 322 VGKL-TFFRVYSGTMTSGSYVK----NSTKGKRE-----RVGRLLQMHANSRQEIDTVYS 371 Query: 451 GNIIGLVGIDQFLLKTGTLTTSETAHN---MKVMKFSVSPVVQVAVEVKNANDLPKLVEG 507 G+I VG L TGT T N ++ M+F PV+ ++VE K+ D K+ + Sbjct: 372 GDIAAAVG----LKDTGTGDTLCGEKNDIILESMEFP-EPVIHLSVEPKSKADQDKMTQA 426 Query: 508 LKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRET 566 L +L + DP + E+G+ I+ G GELHL+I + ++ + V + P+V+YRET Sbjct: 427 LVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEF-NVECNVGAPMVSYRET 485 Query: 567 VESESS-QTALSKSP---NKHNRIYLKAEPIDEEVSLAIENGIIN---PRDDFKARARIM 619 +S + Q S+ ++ ++++ P + EN I+ PR Sbjct: 486 FKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEFENAIVGGVVPR---------- 535 Query: 620 ADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAAFQWATKEGPIFGE 679 E SV A + A + G + G Sbjct: 536 --------------------------------------EYIPSVEAGLKDAMENGVLAGY 557 Query: 680 EMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQA 739 + V+ + D + H +I ++ A DP I EP+ V I+ PE+ Sbjct: 558 PLIDVKAKLYDGSYHDVDSSEMAFKIAASL--ALKEAAKKCDPVILEPMMKVTIEMPEEY 615 Query: 740 VGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFD 799 +G I + +RG+V E R + V AY+P++E FG+ LR T G+ M FD Sbjct: 616 MGDIMGDVTSRRGRVDGMEPRGNAQV--VNAYVPLSEMFGYATSLRSNTQGRGTYTMYFD 673 Query: 800 HWSTLGSDPLDPTSKAGEIV 819 H++ + P S A +I+ Sbjct: 674 HYAEV------PKSIAEDII 687 Score = 84.7 bits (208), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/157 (40%), Positives = 86/157 (54%), Gaps = 24/157 (15%) Query: 20 RNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIKSTAI 75 RN+ +IAH+D GK+T T+ ++ G I K GE A D + EQ+RGITI S A Sbjct: 11 RNIGIIAHIDAGKTTTTERILYYTGRIH--KIGETHEGASQMDWMEQEQDRGITITSAAT 68 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 + E +N+ID+PGHVDF+ EV +LRV DGA+ V+D GV Sbjct: 69 TAAWE----------------GHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGV 112 Query: 136 CVQTETVLRQALGERIKPVVVINKVDR--ALLELQVS 170 QTETV RQA + +V +NK+D+ A E VS Sbjct: 113 EPQTETVWRQATTYGVPRIVFVNKMDKLGANFEYSVS 149 >3CB4-D nrPDB Length = 599 Score = 111 bits (278), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 63/144 (43%), Positives = 93/144 (64%), Gaps = 12/144 (8%) Query: 18 NVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISL 77 N+RN S+IAH+DHGKSTL+D ++Q G +S + EA+ D+ E+ERGITIK+ +++L Sbjct: 3 NIRNFSIIAHIDHGKSTLSDRIIQICGGLSD-REMEAQVLDSMDLERERGITIKAQSVTL 61 Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 D K +DG ++ +N ID+PGHVDFS EV+ +L +GAL+VVD +GV Sbjct: 62 -------DYK----ASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEA 110 Query: 138 QTETVLRQALGERIKPVVVINKVD 161 QT A+ ++ V V+NK+D Sbjct: 111 QTLANCYTAMEMDLEVVPVLNKID 134 >5J8B-z nrPDB Length = 679 Score = 108 bits (270), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 62/157 (39%), Positives = 97/157 (61%), Gaps = 16/157 (10%) Query: 7 DQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQER 66 ++++ +++ ++ +RN S+IAHVDHGKSTL D +++ +S + E +F D+ + E+ER Sbjct: 66 ERLKEILENLSRIRNFSIIAHVDHGKSTLADRILELTHAVSDREMRE-QFLDSLELERER 124 Query: 67 GITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGAL 126 GITIK++A V+ + DG ++ +LID+PGHVDF+ EV+ AL +G L Sbjct: 125 GITIKASA-----------VRVTYRAKDGEEYVFHLIDTPGHVDFTYEVSRALAAVEGVL 173 Query: 127 VVVDTIEGVCVQTETVLRQAL--GERIKPVVVINKVD 161 +VVD +GV +T AL G I P VINK+D Sbjct: 174 LVVDASQGVEAETLAKFYMALEHGHVIIP--VINKID 208 Score = 32.7 bits (73), Expect = 0.64, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 91/206 (44%), Gaps = 21/206 (10%) Query: 373 DPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQ 432 DP+A L + V + +G + R+F G V+ G ++RI Y GK+ + Sbjct: 260 DPEAPLKALIFDSVYDAYQG-VIPYLRLFEGRVRPGDRIRI----YSTGKE-----FTVD 309 Query: 433 RVVLMMGRFVEPIDDCPAGNIIGLVGI--DQFLLKTG-TLTTSETAHNMKVMKFS-VSPV 488 +V + + + + AG + LV D ++ G T+T ++ F PV Sbjct: 310 KVGVFTPQGLVATEALEAGEVGWLVAAIRDIHDVQVGDTITLADRPTPSPYPGFRPAKPV 369 Query: 489 VQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAG-----TGELHLEICLQ 543 V + ++ D KL + L++L +D LT+ ES + G G LH EI + Sbjct: 370 VFAGLYPVDSGDYGKLRDALEKLKLND-AALTFEPESSTALGFGFRCGFLGLLHAEIVQE 428 Query: 544 DLEHDHAGVPLKISPPVVAYRETVES 569 LE + G+ L + P V Y+ ++S Sbjct: 429 RLEREF-GLSLIATAPSVVYKVRLKS 453 Score = 32.3 bits (72), Expect = 1.0, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 27/49 (55%), Gaps = 4/49 (8%) Query: 719 LADP----KIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGT 763 L DP +I EP + I PE+ VG + +L +KRG++V+ PG Sbjct: 465 LPDPTRIEEILEPYVKLTIFTPEEYVGSLMQLLQEKRGRLVNMNYLPGA 513 >5A9Z-CA nrPDB Length = 593 Score = 106 bits (264), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 58/149 (38%), Positives = 85/149 (57%), Gaps = 20/149 (13%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITI--KST 73 + +RN+++IAHVDHGK+TL D L+Q++G + + R D+ E+ERGITI K+T Sbjct: 2 IEKLRNIAIIAHVDHGKTTLVDKLLQQSGTFDSRAETQERVMDSNDLEKERGITILAKNT 61 Query: 74 AISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIE 133 A + + IN++D+PGH DF EV + + D L+VVD + Sbjct: 62 AAIKWD------------------YRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFD 103 Query: 134 GVCVQTETVLRQALGERIKPVVVINKVDR 162 G QT V ++A +KP+VVINKVDR Sbjct: 104 GPMPQTRFVTKKAFAYGLKPIVVINKVDR 132 Score = 31.2 bits (69), Expect = 1.9, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 23/36 (63%), Gaps = 2/36 (5%) Query: 530 VAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRE 565 V+G GELHL + ++++ + G L +S P V +RE Sbjct: 355 VSGRGELHLSVLIENMRRE--GFELAVSRPKVIFRE 388 >5IMR-C nrPDB Length = 610 Score = 103 bits (258), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 62/148 (41%), Positives = 90/148 (60%), Gaps = 16/148 (10%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAI 75 ++ +RN S+IAHVDHGKSTL D +++ +S + E +F D+ + E+ERGITIK++A Sbjct: 6 LSRIRNFSIIAHVDHGKSTLADRILELTHAVSDREMRE-QFLDSLELERERGITIKASA- 63 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 V+ + DG ++ +LID+PGHVDF+ EV+ AL +G L+VVD +GV Sbjct: 64 ----------VRVTYRAKDGEEYVFHLIDTPGHVDFTYEVSRALAAVEGVLLVVDASQGV 113 Query: 136 CVQTETVLRQAL--GERIKPVVVINKVD 161 +T AL G I P VINK+D Sbjct: 114 EAETLAKFYMALEHGHVIIP--VINKID 139 Score = 32.7 bits (73), Expect = 0.62, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 91/206 (44%), Gaps = 21/206 (10%) Query: 373 DPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQ 432 DP+A L + V + +G + R+F G V+ G ++RI Y GK+ + Sbjct: 191 DPEAPLKALIFDSVYDAYQG-VIPYLRLFEGRVRPGDRIRI----YSTGKE-----FTVD 240 Query: 433 RVVLMMGRFVEPIDDCPAGNIIGLVGI--DQFLLKTG-TLTTSETAHNMKVMKFS-VSPV 488 +V + + + + AG + LV D ++ G T+T ++ F PV Sbjct: 241 KVGVFTPQGLVATEALEAGEVGWLVAAIRDIHDVQVGDTITLADRPTPSPYPGFRPAKPV 300 Query: 489 VQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAG-----TGELHLEICLQ 543 V + ++ D KL + L++L +D LT+ ES + G G LH EI + Sbjct: 301 VFAGLYPVDSGDYGKLRDALEKLKLND-AALTFEPESSTALGFGFRCGFLGLLHAEIVQE 359 Query: 544 DLEHDHAGVPLKISPPVVAYRETVES 569 LE + G+ L + P V Y+ ++S Sbjct: 360 RLEREF-GLSLIATAPSVVYKVRLKS 384 Score = 32.3 bits (72), Expect = 0.89, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 27/49 (55%), Gaps = 4/49 (8%) Query: 719 LADP----KIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGT 763 L DP +I EP + I PE+ VG + +L +KRG++V+ PG Sbjct: 396 LPDPTRIEEILEPYVKLTIFTPEEYVGSLMQLLQEKRGRLVNMNYLPGA 444 >4V7D-BZ nrPDB Length = 711 Score = 102 bits (254), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 123/480 (25%), Positives = 198/480 (41%), Gaps = 86/480 (17%) Query: 333 ALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKG 392 A+L+ ++ +LPSPV A G DD + + ++ + T Sbjct: 276 AMLDAVIDYLPSPVDVPAIN------GILDDGKDTPAERHASDDEPFSALAFKIATDPFV 329 Query: 393 RFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGN 452 F RV++G V SG V N V ++ R+V M E I + AG+ Sbjct: 330 GNLTFFRVYSGVVNSGDTVL----NSVKAARERF-----GRIVQMHANKREEIKEVRAGD 380 Query: 453 IIGLVGIDQFLLKTG-TLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRL 511 I +G+ + TG TL + ++ M+F PV+ +AVE K D K+ L RL Sbjct: 381 IAAAIGLKD--VTTGDTLCDPDAPIILERMEFP-EPVISIAVEPKTKADQEKMGLALGRL 437 Query: 512 SKSDPCVLTYM-SESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESE 570 +K DP + ES + I+AG GELHL+I + ++ + V + P VAYRET+ + Sbjct: 438 AKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREF-NVEANVGKPQVAYRETIRQK 496 Query: 571 SSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARARIMADDYGWDVTDA 630 + D E A ++G R + YG V D Sbjct: 497 VT---------------------DVEGKHAKQSG---------GRGQ-----YGHVVID- 520 Query: 631 RKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVV---------AAFQWATKEGPIFGEEM 681 ++ P N K +++++IK V+ Q K GP+ G Sbjct: 521 --MYPLEPGSN--------PKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGPLAG--- 567 Query: 682 RSVRVNILDVTLHADAIHRGGGQIIPTMRRATYA---GFLLADPKIQEPVFLVEIQCPEQ 738 V + + LH + H + A+ A GF A P + EP+ VE++ PE+ Sbjct: 568 --YPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEE 625 Query: 739 AVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVF 798 G + L+++RG + +E + A +P++E FG+ +LR T G+A M F Sbjct: 626 NTGDVIGDLSRRRGMLKGQESE--VTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEF 683 Score = 92.0 bits (227), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 60/152 (39%), Positives = 87/152 (57%), Gaps = 17/152 (11%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ + AH+D GK+T T+ ++ G+ K GE A D + EQERGITI Sbjct: 6 IARYRNIGISAHIDAGKTTTTERILFYTGV--NHKIGEVHDGAATMDWMEQEQERGITIT 63 Query: 72 STAIS-LYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130 S A + +S M+ KQ IN+ID+PGHVDF+ EV ++RV DGA++V Sbjct: 64 SAATTAFWSGMA-------KQY---EPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYC 113 Query: 131 TIEGVCVQTETVLRQALGERIKPVVVINKVDR 162 + GV Q+ETV RQA ++ + +NK+DR Sbjct: 114 AVGGVQPQSETVWRQANKYKVPRIAFVNKMDR 145 >6BK7-A nrPDB Length = 407 Score = 102 bits (253), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 118/449 (26%), Positives = 184/449 (40%), Gaps = 89/449 (19%) Query: 20 RNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIKSTAI 75 RN+ ++AHVD GK+T T+ ++ G I K GE A D + EQERGITI S A Sbjct: 14 RNIGIMAHVDAGKTTTTERILYYTGKIH--KIGETHEGASQMDWMEQEQERGITITSAAT 71 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 + + +N+ID+PGHVDF+ EV +LRV DGA+ V+D+ GV Sbjct: 72 T----------------AQWKGYRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDSQSGV 115 Query: 136 CVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADE 195 QTETV RQA ++ +V NK+D+ + S E L+ + + + D Sbjct: 116 EPQTETVWRQATEYKVPRIVFCNKMDKIGADFFYSVESLHDRLQANAHPIQIPIGAEED- 174 Query: 196 VLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTK 255 G I+ A Y G D + + + + K + Sbjct: 175 -------------------FTGIIDLIKMKAEIYTNDLGTD---IQETDIPEDYLE-KAQ 211 Query: 256 KWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLE 315 +W K +A + E ++ + ++ I V + VL G + Sbjct: 212 EWREKLVEAVAETDEDLMMKYLEGEEITEEELVAGIRQATINV---EFFPVLAGSAFKNK 268 Query: 316 GKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRA-----EQLYEGPADDANCIAIK 370 G L +L+ ++ +LPSP+ A + ++ PADD Sbjct: 269 GVQL--------------MLDAVLDYLPSPLDIDAIKGIDTKTDEETTRPADDEA----- 309 Query: 371 NCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKA 430 P A L K++ GR F RV++G ++SG V N GKK+ Sbjct: 310 ---PFASLAF---KVMTDPFVGRL-TFFRVYSGVLESGSYVL----NASKGKKE-----R 353 Query: 431 IQRVVLMMGRFVEPIDDCPAGNIIGLVGI 459 I R++ M + ID +G+I VG+ Sbjct: 354 IGRILQMHANTRQEIDKVYSGDIAAAVGL 382 >5TY0-A nrPDB Length = 422 Score = 102 bits (253), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 64/147 (43%), Positives = 86/147 (58%), Gaps = 15/147 (10%) Query: 20 RNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIKSTAI 75 RN+ + AHVD GK+T T+ ++ G+ + K GE A D EQERGITI S A Sbjct: 12 RNIGIAAHVDAGKTTTTERVLYYTGM--SHKIGEVHDGAATMDWMVQEQERGITITSAAT 69 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 + Y D+ + S IN+ID+PGHVDF EV +LRV DGA+VV D++ GV Sbjct: 70 TCYWSGMDKQFE---------SHRINIIDTPGHVDFMIEVERSLRVLDGAVVVFDSVAGV 120 Query: 136 CVQTETVLRQALGERIKPVVVINKVDR 162 Q+ETV RQA + +V +NK+DR Sbjct: 121 EPQSETVWRQANKYGVPRIVFVNKMDR 147 >5VH6-A nrPDB Length = 409 Score = 94.7 bits (234), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 59/147 (40%), Positives = 82/147 (55%), Gaps = 22/147 (14%) Query: 20 RNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIKSTAI 75 RN+ ++AH+D GK+T T+ ++ G I K GE A D + EQERGITI S A Sbjct: 14 RNIGIMAHIDAGKTTTTERILFYTGRIH--KIGETHEGASQMDWMEQEQERGITITSAAT 71 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 + + +N+ID+PGHVDF+ EV +LRV DGA+ V+D GV Sbjct: 72 T----------------AQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGV 115 Query: 136 CVQTETVLRQALGERIKPVVVINKVDR 162 QTETV RQA + +V +NK+D+ Sbjct: 116 EPQTETVWRQATTYGVPRIVFVNKMDK 142 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 59/135 (43%), Gaps = 34/135 (25%) Query: 334 LLEMIVLHLPSPVTAQAYRA------EQLYEGPADDA--NCIAIK-NCDPKADLMLYVSK 384 +L+ ++ +LP+P A + E++ +D+ + +A K DP YV K Sbjct: 273 VLDAVLDYLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDP------YVGK 326 Query: 385 MVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEP 444 + F RV++GT+ SG V+ N GK++ + R++ M E Sbjct: 327 LT----------FFRVYSGTLDSGSYVK----NSTKGKRE-----RVGRILQMHANSREE 367 Query: 445 IDDCPAGNIIGLVGI 459 I AG+I VG+ Sbjct: 368 ISTVYAGDIAAAVGL 382 >6B8D-A nrPDB Length = 408 Score = 92.4 bits (228), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 60/148 (40%), Positives = 87/148 (58%), Gaps = 17/148 (11%) Query: 20 RNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIKSTAI 75 RN+ + AH+D GK+T T+ ++ G+ + K GE A D + EQERGITI S A Sbjct: 14 RNIGISAHIDAGKTTTTERILFYTGV--SHKIGEVHDGAATMDWMEQEQERGITITSAAT 71 Query: 76 S-LYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 + +S MS ++ Q IN+ID+PGHVDF+ EV ++RV DGA++V + G Sbjct: 72 TAFWSGMS----QQFPQHR------INVIDTPGHVDFTVEVERSMRVLDGAVMVYCAVGG 121 Query: 135 VCVQTETVLRQALGERIKPVVVINKVDR 162 V Q+ETV RQA + + +NK+DR Sbjct: 122 VQPQSETVWRQANKYEVPRIAFVNKMDR 149 >2MZW-A nrPDB Length = 301 Score = 89.7 bits (221), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 84/341 (24%), Positives = 143/341 (41%), Gaps = 67/341 (19%) Query: 487 PVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQDL 545 PV+ ++VE K+ D K+ + L +L + DP + E+G+ I+ G GELHL+I + + Sbjct: 6 PVIHLSVEPKSKADQDKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRM 65 Query: 546 EHDHAGVPLKISPPVVAYRETVESESS-QTALSKSPN---KHNRIYLKAEPIDEEVSLAI 601 + + V + P+V+YRET +S + Q S+ ++ ++++ P + Sbjct: 66 KKEF-NVECNVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEF 124 Query: 602 ENGIIN---PRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHE 658 EN I+ PR E Sbjct: 125 ENAIVGGVVPR------------------------------------------------E 136 Query: 659 IKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFL 718 SV A + A + G + G + V+ + D + H +I ++ A Sbjct: 137 YIPSVEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASL--ALKEAAK 194 Query: 719 LADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESF 778 DP I EP+ V I+ PE+ +G I + +RG+V E R + V AY+P++E F Sbjct: 195 KCDPVILEPMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQV--VNAYVPLSEMF 252 Query: 779 GFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIV 819 G+ LR T G+ M FDH++ + P S A +I+ Sbjct: 253 GYATSLRSNTQGRGTYTMYFDHYAEV------PKSIAEDII 287 >4V6V-A1 nrPDB Length = 639 Score = 89.4 bits (220), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 55/150 (36%), Positives = 86/150 (57%), Gaps = 20/150 (13%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIIS---AAKAGEARFTDTRKDEQERGITIKSTAISL 77 N+ ++AHVD GK+TLT+SL+ +G I+ + G R TDT E++RGITI++ S Sbjct: 5 NLGILAHVDAGKTTLTESLLYTSGAIAELGSVDEGTTR-TDTMNLERQRGITIQTAVTSF 63 Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 EDVK +N+ID+PGH+DF +EV +L V DGA+++V +G+ Sbjct: 64 ----QWEDVK------------VNIIDTPGHMDFLAEVYRSLSVLDGAVLLVSAKDGIQA 107 Query: 138 QTETVLRQALGERIKPVVVINKVDRALLEL 167 QT + +I + INK+D+ ++L Sbjct: 108 QTRILFHALQIMKIPTIFFINKIDQEGIDL 137 Score = 38.5 bits (88), Expect = 0.011, Method: Compositional matrix adjust. Identities = 57/269 (21%), Positives = 107/269 (39%), Gaps = 43/269 (15%) Query: 389 SDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDC 448 S+K R + + R+++GT+ +RI +K+ IK + V G C Sbjct: 259 SEKRRRFVYVRIYSGTLHLRDVIRI-------SEKEK--IKITEMYVPTNGELYSSDTAC 309 Query: 449 PAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGL 508 +G+I+ L +L+ ++ +E + + P++Q + VK + L+ L Sbjct: 310 -SGDIVIL---PNDVLQLNSILGNEILLPQRKFIENPLPMIQTTIAVKKSEQREILLGAL 365 Query: 509 KRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETV 567 +S DP + Y+ + + E I++ G + +E+ LE + V +I P V Y E Sbjct: 366 TEISDCDPLLKYYVDTTTHEIILSFLGNVQMEVICAILEEKYH-VEAEIKEPTVIYMERP 424 Query: 568 ESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARARIMADD----- 622 ++ T + P P V L+IE I +++R + + Sbjct: 425 LRKAEYTIHIEVP---------PNPFWASVGLSIEPLPIGSGVQYESRVSLGYLNQSFQN 475 Query: 623 --------------YGWDVTDARKIWCFG 637 YGW VTD + + +G Sbjct: 476 AVMEGVLYGCEQGLYGWKVTDCKICFEYG 504 >1WDT-A nrPDB Length = 665 Score = 85.9 bits (211), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 145/601 (24%), Positives = 237/601 (39%), Gaps = 141/601 (23%) Query: 19 VRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLY 78 +R ++++ H GK+TLT++L+ + G R+ E G T +T + Sbjct: 9 IRTVALVGHAGSGKTTLTEALLYKTG------------AKERRGRVEEGTT--TTDYTPE 54 Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQ 138 +++ V+ + L+D+PG+ DF E+ AL D ALV V GV V Sbjct: 55 AKLHRTTVRTGVAPLLFRGHRVFLLDAPGYGDFVGEIRGALEAADAALVAVSAEAGVQVG 114 Query: 139 TETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLG 198 TE A + +VV+ K+D+ D Y ++ I+ Sbjct: 115 TERAWTVAERLGLPRMVVVTKLDKG--------GDYYALLEDLRSTLGPILPI------- 159 Query: 199 DVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWT 258 D+ +Y V HG A+ RY Sbjct: 160 DLPLYEGGKWVGLIDVFHGKAY-------RYE---------------------------N 185 Query: 259 NKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEK----LEIVLKGDEKDL 314 ++ +AE P ER + F+++ + ++E LE L+G+E Sbjct: 186 GEEREAEVPPEER--------------ERVQRFRQEVLEAIVETDEGLLEKYLEGEEVTG 231 Query: 315 EG--KALLKVVMRKFL-PAADA----------LLEMIVLHLPSPVTAQAYRAEQLYEGPA 361 E KA + V R L P A A LLE+I+ LPSP E+ +GP Sbjct: 232 EALEKAFHEAVRRGLLYPVALASGEREIGVLPLLELILEALPSPT-------ERFGDGPP 284 Query: 362 DDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPN-YVP 420 A ++ DP + Y+ R Y GR+ G + +++ P+ YVP Sbjct: 285 L-AKVFKVQ-VDPFMGQVAYL----------RLYR-GRLKPGDSLQSEAGQVRLPHLYVP 331 Query: 421 GKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKV 480 MG+ + +++ AG ++G V + L + L E + +V Sbjct: 332 -----------------MGKDLLEVEEAEAGFVLG-VPKAEGLHRGMVLWQGEKPESEEV 373 Query: 481 MKFSV-SPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCV-LTYMSESGEHIVAGTGELHL 538 + P V VA+ K D +L E L++L + DP + L E+GE ++ G GELHL Sbjct: 374 PFARLPDPNVPVALHPKGRTDEARLGEALRKLLEEDPSLKLERQEETGELLLWGHGELHL 433 Query: 539 EICLQDLEHDHAGVPLKISPPVVAYRETVES-ESSQTALSKSPNKHNR---IYLKAEPID 594 + L+ D+ GV ++ S P V YRET++ Q K H + ++L+ EP Sbjct: 434 ATAKERLQ-DY-GVEVEFSVPKVPYRETIKKVAEGQGKYKKQTGGHGQYGDVWLRLEPAS 491 Query: 595 E 595 E Sbjct: 492 E 492 Score = 43.5 bits (101), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 43/83 (51%), Gaps = 2/83 (2%) Query: 720 ADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFG 779 A P + EP++ +++ P++ VG + S L +RG+++ EQ L V A +P+ E Sbjct: 567 AHPVLLEPIYRLKVLAPQERVGDVLSDLQARRGRILGMEQE--GALSVVHAEVPLAEVLE 624 Query: 780 FTGELRQATGGQAFPQMVFDHWS 802 + L TGG + F H++ Sbjct: 625 YYKALPGLTGGAGAYTLEFSHYA 647 >5KCS-1w nrPDB Length = 639 Score = 85.1 bits (209), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 53/157 (33%), Positives = 85/157 (54%), Gaps = 20/157 (12%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIIS---AAKAGEARFTDTRKDEQERGITIKSTAISL 77 N+ V+AHVD GK+TLT+SL+ +G I+ + G R TD E++RGITI++ S Sbjct: 5 NIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTR-TDNTLLERQRGITIQTGITSF 63 Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 E + +N+ID+PGH+DF +EV +L V DGA++++ +GV Sbjct: 64 QWENTK----------------VNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQA 107 Query: 138 QTETVLRQALGERIKPVVVINKVDRALLELQVSKEDL 174 QT + I + INK+D+ ++L +D+ Sbjct: 108 QTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDI 144 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 64/273 (23%), Positives = 115/273 (42%), Gaps = 26/273 (9%) Query: 376 ADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVV 435 ++L V K+ T + R A+ R+++G + VR+ +K+ IK + Sbjct: 247 SELCGNVFKIEYTKKRQRL-AYIRLYSGVLHLRDSVRV-------SEKEK--IKVTEMYT 296 Query: 436 LMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEV 495 + G + ID +G I+ L ++FL L ++ K ++ + P++Q VE Sbjct: 297 SINGELCK-IDRAYSGEIVILQ--NEFLKLNSVLGDTKLLPQRKKIE-NPHPLLQTTVEP 352 Query: 496 KNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQDLEHDHAGVPL 554 L++ L +S SDP + Y+ S + E I++ G++ +E+ + L + V + Sbjct: 353 SKPEQREMLLDALLEISDSDPLLRYYVDSTTHEIILSFLGKVQMEV-ISALLQEKYHVEI 411 Query: 555 KISPPVVAYRETVESESSQTA-LSKSPNKH-NRIYLKAEPI--------DEEVSLAIENG 604 +I+ P V Y E + T + PN I L P+ + VSL N Sbjct: 412 EITEPTVIYMERPLKNAEYTIHIEVPPNPFWASIGLSVSPLPLGSGMQYESSVSLGYLNQ 471 Query: 605 IINPRDDFKARARIMADDYGWDVTDARKIWCFG 637 R YGW+VTD + + +G Sbjct: 472 SFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYG 504 >5TV2-A nrPDB Length = 405 Score = 83.2 bits (204), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 60/148 (40%), Positives = 86/148 (58%), Gaps = 15/148 (10%) Query: 20 RNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIKSTAI 75 RN+ + AHVD GK+T T+ ++ G+ + K GE A D + EQERGITI S A Sbjct: 11 RNIGICAHVDAGKTTTTERILFYTGL--SHKIGEVHDGAATMDWMEQEQERGITITSAAT 68 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 + + + ++ + +N+ID+PGHVDF+ EV +LRV DGA+VV GV Sbjct: 69 TTFWRGMEAQFQDHR---------VNIIDTPGHVDFTIEVERSLRVLDGAVVVFCGSSGV 119 Query: 136 CVQTETVLRQALGERIKPVVVINKVDRA 163 Q+ETV RQA + +V +NK+DRA Sbjct: 120 EPQSETVWRQADKYHVPRMVFVNKMDRA 147 Score = 29.6 bits (65), Expect = 5.6, Method: Compositional matrix adjust. Identities = 31/127 (24%), Positives = 52/127 (40%), Gaps = 17/127 (13%) Query: 333 ALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKG 392 A+L+ ++ +LPSP+ A + D+ + ++ D K+ G Sbjct: 277 AVLDAVIEYLPSPIDVPAIKG-------IDENDNEVERHADDNEPFSALAFKIATDPFVG 329 Query: 393 RFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGN 452 F RV++G V +G V N V KK+ R+V M E I + AG+ Sbjct: 330 TL-TFIRVYSGVVNTGDAVY----NSVKQKKERF-----GRIVQMHANKREEIKEVRAGD 379 Query: 453 IIGLVGI 459 I +G+ Sbjct: 380 IAAAIGL 386 >3TR5-A nrPDB Length = 528 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 46/150 (30%), Positives = 76/150 (50%), Gaps = 24/150 (16%) Query: 20 RNMSVIAHVDHGKSTLTDSL------VQRAGIISAAKAGEARFTDTRKDEQERGITIKST 73 R ++I+H D GK+TLT+ L +Q AG I + KA +D + E++RGI++ ++ Sbjct: 14 RTFAIISHPDAGKTTLTEKLLLFGGAIQLAGTIKSRKAARHATSDWMELEKQRGISVTTS 73 Query: 74 AISL-YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTI 132 + Y + +LINL+D+PGH DF+ + L D AL+V+D Sbjct: 74 VMQFPYKD-----------------YLINLLDTPGHADFTEDTYRTLTAVDSALMVIDAA 116 Query: 133 EGVCVQTETVLRQALGERIKPVVVINKVDR 162 +GV +T ++ + INK+DR Sbjct: 117 KGVEPRTIKLMEVCRLRHTPIMTFINKMDR 146 >3VQT-A nrPDB Length = 548 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 50/154 (32%), Positives = 77/154 (50%), Gaps = 26/154 (16%) Query: 21 NMSVIAHVDHGKSTLTDSL------VQRAGIISAAKAGEARFTDTRKDEQERGITIKSTA 74 ++I+H D GK+TLT+ L +Q AG + A KA +D E+ERGI++ ++ Sbjct: 33 TFAIISHPDAGKTTLTEKLLLFGGAIQMAGSVKARKAARHATSDWMAMERERGISVTTSV 92 Query: 75 ISL-YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIE 133 + Y + ++NL+D+PGH DFS + L D ALVV+D + Sbjct: 93 MQFPYRDR-----------------VVNLLDTPGHQDFSEDTYRVLTAVDSALVVIDAAK 135 Query: 134 GVCVQTETVLRQALGERIKPVVV-INKVDRALLE 166 GV QT ++ R PV+ +NK+DR L Sbjct: 136 GVEAQTRKLM-DVCRMRATPVMTFVNKMDREALH 168 >4V89-AW nrPDB Length = 534 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 76/157 (48%), Gaps = 24/157 (15%) Query: 13 MDKVTNVRNMSVIAHVDHGKSTLTDSL------VQRAGIISAAKAGEARFTDTRKDEQER 66 + +V R ++I+H D GK+T+T+ + +Q AG + + + +D + E++R Sbjct: 7 LQEVAKRRTFAIISHPDAGKTTITEKVLLFGQAIQTAGTVKGRGSNQHAKSDWMEMEKQR 66 Query: 67 GITIKSTAISL-YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 GI+I ++ + Y + L+NL+D+PGH DFS + L D Sbjct: 67 GISITTSVMQFPYHDC-----------------LVNLLDTPGHEDFSEDTYRTLTAVDCC 109 Query: 126 LVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDR 162 L+V+D +GV +T ++ + +NK+DR Sbjct: 110 LMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKLDR 146 >3WXM-A nrPDB Length = 447 Score = 60.5 bits (145), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/166 (31%), Positives = 73/166 (43%), Gaps = 43/166 (25%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGEARFT-----DTRKDEQE 65 N+ VI HVDHGKSTL L+ R G I A G+ F D K+E+E Sbjct: 11 NLVVIGHVDHGKSTLVGHLLYRLGYIEEKKLKELEEQAKSRGKESFKFAWILDKMKEERE 70 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RGITI T + K + ++ +ID+PGH DF + D A Sbjct: 71 RGITIDLTFM----------------KFETKKYVFTIIDAPGHRDFVKNMITGASQADAA 114 Query: 126 LVVVDTIEG---VCVQTETVLRQALG-------ERIKPVVVINKVD 161 ++VV +G + TE R+ L E+I +V +NK+D Sbjct: 115 ILVVSARKGEFEAGMSTEGQTREHLLLARTMGIEQI--IVAVNKMD 158 >1JNY-A nrPDB Length = 435 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 41/165 (24%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGE-----ARFTDTRKDEQE 65 N+ VI HVDHGKSTL L+ G I +A K G+ A D K+E+E Sbjct: 8 NLIVIGHVDHGKSTLVGRLLMDRGFIDEKTVKEAEEAAKKLGKESEKFAFLLDRLKEERE 67 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RG+TI T + ++ + +ID+PGH DF + D A Sbjct: 68 RGVTINLTFMRFETK----------------KYFFTIIDAPGHRDFVKNMITGASQADAA 111 Query: 126 LVVVDTIE-----GVCVQTET----VLRQALGERIKPVVVINKVD 161 ++VV + G+ V+ +T +L + +G + +V +NK+D Sbjct: 112 ILVVSAKKGEYEAGMSVEGQTREHIILAKTMGLD-QLIVAVNKMD 155 >5W76-A nrPDB Length = 385 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/149 (32%), Positives = 70/149 (46%), Gaps = 31/149 (20%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARF-----TDTRKDEQERGITIKSTAI 75 N+ I HVDHGK+TLT ++ + A+ G+A F D +E+ERGITI + + Sbjct: 6 NIGTIGHVDHGKTTLTAAITK-----VLAEKGQAEFKAYDQIDKAPEEKERGITISTAHV 60 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 +E N + +D PGH D+ + DGA++VV +G Sbjct: 61 EYETE---------------NRHYAH-VDCPGHADYVKNMITGAAQMDGAILVVSAADGP 104 Query: 136 CVQT-ETVL--RQALGERIKPVVVINKVD 161 QT E +L RQ I VV +NKVD Sbjct: 105 MPQTREHILLARQVGVPYI--VVFLNKVD 131 >4AC9-A nrPDB Length = 482 Score = 56.6 bits (135), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 46/143 (32%), Positives = 65/143 (45%), Gaps = 25/143 (17%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ + H+DHGK+TL+ L + A + K E+ Q+RGITI +S Sbjct: 21 NLGIFGHIDHGKTTLSKVLTEIASTSAHDKLPES---------QKRGITIDIG----FSA 67 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTE 140 E+ + I L+D+PGH D V +A + D AL+VVD EG QT Sbjct: 68 FKLEN------------YRITLVDAPGHADLIRAVVSAADIIDLALIVVDAKEGPKTQTG 115 Query: 141 TVLRQALGERIKPVVVINKVDRA 163 + I +VVI K D A Sbjct: 116 EHMLILDHFNIPIIVVITKSDNA 138 >4ZV4-A nrPDB Length = 405 Score = 55.8 bits (133), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 54/169 (31%), Positives = 76/169 (44%), Gaps = 32/169 (18%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARF---TDTRKDEQERGITIKSTAISL 77 N+ I HVDHGK+TLT +L + + S G AR D +E+ RGITI ++ + Sbjct: 14 NVGTIGHVDHGKTTLTAALTK---VCSDTWGGSARAFDQIDNAPEEKARGITINTSHVEY 70 Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 D V+ +D PGH D+ + DGA++V +G Sbjct: 71 -----DSAVRHYAH-----------VDCPGHADYVKNMITGAAQMDGAILVCSAADGPMP 114 Query: 138 QT-ETVL--RQALGERIKPVVVINKVDRA----LLEL-QVSKEDLYQTF 178 QT E +L RQ I VV +NK D LLEL ++ DL T+ Sbjct: 115 QTREHILLSRQVGVPYI--VVFLNKADMVDDAELLELVEMEVRDLLNTY 161 >5W75-A nrPDB Length = 392 Score = 55.5 bits (132), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 51/175 (29%), Positives = 75/175 (42%), Gaps = 24/175 (13%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ I HVDHGKSTLT ++ + + A+ D +E+ RGITI T + +E Sbjct: 6 NVGTIGHVDHGKSTLTAAITKYLSLKGLAQYVPYDQIDKAPEEKARGITINITHVEYETE 65 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT- 139 ID PGH D+ + DGA++VV +G QT Sbjct: 66 KRH----------------YAHIDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTR 109 Query: 140 -ETVLRQALGERIKPVVVINKVDRA----LLEL-QVSKEDLYQTFARTVESVNVI 188 +L + +G +V INK D L+EL ++ DL + + V VI Sbjct: 110 EHVLLARQVGVPYM-IVFINKTDMVDDPELIELVEMEVRDLLSQYEYPGDEVPVI 163 >4C0S-A nrPDB Length = 463 Score = 55.5 bits (132), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 42/124 (33%), Positives = 57/124 (45%), Gaps = 31/124 (25%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGEARFT-----DTRKDEQE 65 N+ VI HVD GKST T L+ + G I AA+ G+ F D K E+E Sbjct: 9 NIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERE 68 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RGITI ISL+ K + + I +ID+PGH DF + D A Sbjct: 69 RGITID---ISLW-------------KFETTKYYITIIDAPGHRDFIKNMITGTSQADCA 112 Query: 126 LVVV 129 +++V Sbjct: 113 VLIV 116 >5LZS-jj nrPDB Length = 462 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 41/124 (33%), Positives = 58/124 (46%), Gaps = 31/124 (25%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGEARFT-----DTRKDEQE 65 N+ VI HVD GKST T L+ + G I AA+ G+ F D K E+E Sbjct: 9 NIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERE 68 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RGITI ISL+ K + + + + +ID+PGH DF + D A Sbjct: 69 RGITID---ISLW-------------KFETSKYYVTIIDAPGHRDFIKNMITGTSQADCA 112 Query: 126 LVVV 129 +++V Sbjct: 113 VLIV 116 >4J0Q-A nrPDB Length = 433 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 50/166 (30%), Positives = 73/166 (43%), Gaps = 26/166 (15%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ I HVDHGK+TLT +L + + + E D+ +E+ RGITI + + S Sbjct: 50 NVGTIGHVDHGKTTLTAALTRVCSEVFGSAIVEFDKIDSAPEEKARGITINTAHVEYNST 109 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT- 139 + +D PGH D+ + DGA++V +G QT Sbjct: 110 IRH----------------YAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTR 153 Query: 140 ETVL--RQALGERIKPVVVINKVDRA----LLEL-QVSKEDLYQTF 178 E +L RQ I VV +NK D LLEL ++ DL T+ Sbjct: 154 EHILLSRQVGVPYI--VVFLNKADLVDDAELLELVEMEVRDLLSTY 197 >1D2E-A nrPDB Length = 397 Score = 53.9 bits (128), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 51/181 (28%), Positives = 75/181 (41%), Gaps = 30/181 (16%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ I HVDHGK+TLT ++ + AK + D +E+ RGITI + + YS Sbjct: 5 NVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVE-YST 63 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTE 140 + D PGH D+ + DG ++VV +G QT Sbjct: 64 AARHYAH---------------TDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTR 108 Query: 141 TVL---RQALGERIKPVVVINKVDRA-------LLELQVSKEDLYQTFARTVESVNVIVS 190 L RQ E + VV +NK D L+EL++ +L F E +IV Sbjct: 109 EHLLLARQIGVEHV--VVYVNKADAVQDSEMVELVELEI--RELLTEFGYKGEETPIIVG 164 Query: 191 T 191 + Sbjct: 165 S 165 >5W7Q-A nrPDB Length = 373 Score = 53.5 bits (127), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 21/144 (14%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ I HVDHGK+TLT ++ A+A D +E+ RGITI + + +E Sbjct: 7 NIGTIGHVDHGKTTLTAAITTVLAKKGGAEAKAYDQIDNAPEEKARGITINTAHVEYETE 66 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT- 139 N + +D PGH D+ + DGA++VV +G QT Sbjct: 67 ---------------NRHYAH-VDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTR 110 Query: 140 ETVL--RQALGERIKPVVVINKVD 161 E +L RQ I VV +NK D Sbjct: 111 EHILLARQVGVPYI--VVFLNKCD 132 >3IZY-P nrPDB Length = 537 Score = 52.0 bits (123), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/180 (29%), Positives = 80/180 (44%), Gaps = 43/180 (23%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK+TL D L R ++A +AG GIT A L S Sbjct: 7 VTIMGHVDHGKTTLLDKL--RKTQVAAMEAG--------------GITQHIGAF-LVSLP 49 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 S E I +D+PGH FS+ +VTD ++VV +GV QT Sbjct: 50 SGEK--------------ITFLDTPGHAAFSAMRARGTQVTDIVILVVAADDGVMKQTVE 95 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQ 201 ++ A + V+ INK D+A + + K++L + +V+ Y GDVQ Sbjct: 96 SIQHAKDAHVPIVLAINKCDKAEADPEKVKKELL--------AYDVVCEDYG----GDVQ 143 >3MMP-A nrPDB Length = 678 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 43/148 (29%), Positives = 67/148 (45%), Gaps = 29/148 (19%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARF---TDTRKDEQERGITIKSTAISL 77 N+ I HVDHGK+TLT ++ +++ G AR D +E+ RGITI ++ + Sbjct: 298 NVGTIGHVDHGKTTLTAAITT---VLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEY 354 Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 D + +D PGH D+ + DGA++VV +G Sbjct: 355 ----------------DTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMP 398 Query: 138 QT-ETVLRQALGERIKP---VVVINKVD 161 QT E +L LG ++ +V +NK D Sbjct: 399 QTREHIL---LGRQVGVPYIIVFLNKCD 423 >6MIJ-A nrPDB Length = 396 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 36/122 (29%), Positives = 55/122 (45%), Gaps = 22/122 (18%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEAR---FTDTRKDEQERGITIKSTAISL 77 N+ I HVDHGK+TLT ++ A I + GEA+ D+ +E+ RGITI ++ + Sbjct: 14 NVGTIGHVDHGKTTLTAAI---ATICAKTYGGEAKDYSQIDSAPEEKARGITINTSHVEY 70 Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 D + +D PGH D+ + DGA++V +G Sbjct: 71 ----------------DSPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVCAATDGPMP 114 Query: 138 QT 139 QT Sbjct: 115 QT 116 >2B7C-A nrPDB Length = 458 Score = 51.6 bits (122), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 41/132 (31%), Positives = 60/132 (45%), Gaps = 31/132 (23%) Query: 13 MDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGEARFT----- 57 M K + N+ VI HVD GKST T L+ + G I AA+ G+ F Sbjct: 1 MGKEKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVL 60 Query: 58 DTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTA 117 D K E+ERGITI I+L+ K + + + +ID+PGH DF + Sbjct: 61 DKLKAERERGITID---IALW-------------KFETPKYQVTVIDAPGHRDFIKNMIT 104 Query: 118 ALRVTDGALVVV 129 D A++++ Sbjct: 105 GTSQADCAILII 116 >5YT0-A nrPDB Length = 364 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 45/142 (31%), Positives = 66/142 (46%), Gaps = 20/142 (14%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSD 83 V+ HVDHGK+TL D + + A ++A +AG GIT + S+ Sbjct: 21 VLGHVDHGKTTLLDKIRRTA--VAAKEAG--------------GIT-QHIGASIVPADVI 63 Query: 84 EDVKEIKQKTDGNSFLIN---LIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTE 140 E + E +K +I ID+PGH FS+ V D A++VVD +EG QT Sbjct: 64 EKIAEPLKKVIPVKLVIPGLLFIDTPGHELFSNLRRRGGSVADFAILVVDIMEGFKPQTY 123 Query: 141 TVLRQALGERIKPVVVINKVDR 162 L R+ ++ NK+DR Sbjct: 124 EALELLKERRVPFLIAANKIDR 145 >6GB2-BC nrPDB Length = 657 Score = 50.8 bits (120), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/183 (27%), Positives = 80/183 (43%), Gaps = 43/183 (23%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK+TL D R ++A + G GIT A L S Sbjct: 113 VTIMGHVDHGKTTLLDKF--RKTQVAAVETG--------------GITQHIGAF-LVSLP 155 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 S E I +D+PGH FS+ +VTD ++VV +GV QT Sbjct: 156 SGEK--------------ITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVE 201 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQ 201 ++ A ++ ++ +NK D+A + + K++L + +V+ Y GDVQ Sbjct: 202 SIQHAKDAQVPIILAVNKCDKAEADPEKVKKELL--------AYDVVCEDYG----GDVQ 249 Query: 202 VYP 204 P Sbjct: 250 AVP 252 >2D74-A nrPDB Length = 419 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/116 (31%), Positives = 51/116 (43%), Gaps = 20/116 (17%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK----STAIS 76 N+ ++ HVDHGK+TLT +L +TDT +E RGITIK I Sbjct: 13 NIGMVGHVDHGKTTLTKALT-------------GVWTDTHSEELRRGITIKIGFADAEIR 59 Query: 77 LYSEMSDEDVKEIKQKTDGNSFLI---NLIDSPGHVDFSSEVTAALRVTDGALVVV 129 S I + I + IDSPGH + + A + DGA++V+ Sbjct: 60 RCSNCGRYSTSPICPYCGHETEFIRRVSFIDSPGHEALMTTMLAGASLMDGAILVI 115 >5FG3-A nrPDB Length = 623 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 45/142 (31%), Positives = 66/142 (46%), Gaps = 20/142 (14%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSD 83 V+ HVDHGK+TL D + + A ++A +AG GIT + S+ Sbjct: 21 VLGHVDHGKTTLLDKIRRTA--VAAKEAG--------------GIT-QHIGASIVPADVI 63 Query: 84 EDVKEIKQKTDGNSFLIN---LIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTE 140 E + E +K +I ID+PGH FS+ V D A++VVD +EG QT Sbjct: 64 EKIAEPLKKVIPVKLVIPGLLFIDTPGHELFSNLRRRGGSVADFAILVVDIMEGFKPQTY 123 Query: 141 TVLRQALGERIKPVVVINKVDR 162 L R+ ++ NK+DR Sbjct: 124 EALELLKERRVPFLIAANKIDR 145 >5LZY-jj nrPDB Length = 710 Score = 50.4 bits (119), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 42/129 (32%), Positives = 60/129 (46%), Gaps = 31/129 (24%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIIS----------AAKAGEARFT-----DTRKDEQE 65 N+ VI HVD GKSTL ++ G I+ + KAG+A F D +E+E Sbjct: 288 NLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAYAWVLDETGEERE 347 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RG+T+ DV K +T + +I L+D+PGH DF + D A Sbjct: 348 RGVTM--------------DVGMTKFET--TTKVITLMDAPGHKDFIPNMITGAAQADVA 391 Query: 126 LVVVDTIEG 134 ++VVD G Sbjct: 392 VLVVDASRG 400 >1MJ1-A nrPDB Length = 405 Score = 49.3 bits (116), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 52/180 (28%), Positives = 82/180 (45%), Gaps = 33/180 (18%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARF-----TDTRKDEQERGITIKSTAI 75 N+ I HVDHGK+TLT +L ++AA+ D ++E+ RGITI + Sbjct: 13 NVGTIGHVDHGKTTLTAALT----YVAAAENRNVEVKDYGDIDKAREERARGITINTA-- 66 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 ++ +T + + +D GH D+ + DGA++VV +G Sbjct: 67 ------------HVEYETAKRHY--SHVDCRGHADYIKNMITGAAQMDGAILVVSAADGR 112 Query: 136 CVQT--ETVLRQALGERIKPVVVINKV----DRALLEL-QVSKEDLYQTFARTVESVNVI 188 QT +L + +G R VV +NKV DR LL+L ++ DL + + V VI Sbjct: 113 MRQTREHILLARQVGVRY-IVVFMNKVDMVDDRELLDLVEMEVRDLLNQYEFRGDEVRVI 171 >3MCA-A nrPDB Length = 592 Score = 48.5 bits (114), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/189 (28%), Positives = 84/189 (44%), Gaps = 48/189 (25%) Query: 19 VRNMSVIAHVDHGKSTLTDSLVQRAGIIS----------AAKAGEARFT-----DTRKDE 63 V ++ V HVD GKST+ ++ G I+ AA +G+ F+ DT ++E Sbjct: 177 VVHLVVTGHVDSGKSTMLGRIMFELGEINSRSMQKLHNEAANSGKGSFSYAWLLDTTEEE 236 Query: 64 QERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTD 123 + RG+T+ + + SD+ + EI D+PGH DF S + A D Sbjct: 237 RARGVTMDVASTTF---ESDKKIYEIG-------------DAPGHRDFISGMIAGASSAD 280 Query: 124 GALVVVDT---------IEGVCVQTETVLRQALGERIKPVVV-INKVDRALLELQVSKED 173 A++VVD+ +E + L +ALG I +VV +NK+D L ED Sbjct: 281 FAVLVVDSSQNNFERGFLENGQTREHAYLLRALG--ISEIVVSVNKLD-----LMSWSED 333 Query: 174 LYQTFARTV 182 +Q V Sbjct: 334 RFQEIKNIV 342 >4V5G-AZ nrPDB Length = 406 Score = 48.5 bits (114), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/149 (30%), Positives = 68/149 (45%), Gaps = 30/149 (20%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARF-----TDTRKDEQERGITIKSTAI 75 N+ I HVDHGK+TLT +L ++AA+ D +E+ RGITI + Sbjct: 14 NVGTIGHVDHGKTTLTAALT----YVAAAENPNVEVKDYGDIDKAPEERARGITINTA-- 67 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 ++ +T + + +D PGH D+ + DGA++VV +G Sbjct: 68 ------------HVEYETAKRHY--SHVDCPGHADYIKNMITGAAQMDGAILVVSAADGP 113 Query: 136 CVQT-ETVL--RQALGERIKPVVVINKVD 161 QT E +L RQ I VV +NKVD Sbjct: 114 MPQTREHILLARQVGVPYI--VVFMNKVD 140 >3WY9-A nrPDB Length = 434 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/157 (35%), Positives = 72/157 (45%), Gaps = 34/157 (21%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAA------KAGE-------ARFTDTRKDEQERG 67 N+ I HVDHGKST L+ G I + GE A D K+E+ERG Sbjct: 9 NIVFIGHVDHGKSTTIGRLLYDTGNIPETIIKKFEEMGEKGKSFKFAWVMDRLKEERERG 68 Query: 68 ITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALV 127 ITI DV K +T I +ID+PGH DF + D A++ Sbjct: 69 ITI--------------DVAHTKFETPHR--YITIIDAPGHRDFVKNMITGASQADAAVL 112 Query: 128 VVDTIEGVCVQTE--TVLRQALGERIKPVVV-INKVD 161 VV +GV QT+ L + LG IK ++V INK+D Sbjct: 113 VVAATDGVMPQTKEHAFLARTLG--IKHIIVTINKMD 147 >4UJC-AB nrPDB Length = 627 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 41/143 (28%), Positives = 67/143 (46%), Gaps = 18/143 (12%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 + V+ HVD GK+ + D L R + +AG GIT + A ++ E Sbjct: 41 ICVLGHVDTGKTKILDKL--RHTHVQDGEAG--------------GITQQIGATNVPLEA 84 Query: 82 SDEDVKEIKQKTDGNSFL--INLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 +E K IK N + + +ID+PGH FS+ + D A++VVD + G+ QT Sbjct: 85 INEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQT 144 Query: 140 ETVLRQALGERIKPVVVINKVDR 162 + ++ +V +NK+DR Sbjct: 145 IESINLLKSKKCPFIVALNKIDR 167 >4NCL-A nrPDB Length = 457 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 90/198 (45%), Gaps = 37/198 (18%) Query: 11 SLMDKVTNVRN--MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGI 68 S M+K N+R+ ++ HVD GK+ L D + Q + + GEA GI Sbjct: 1 SHMNK-DNLRSPICCILGHVDTGKTKLLDKIRQ-----TNVQEGEAG-----------GI 43 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKT-----DGNSFL----INLIDSPGHVDFSSEVTAAL 119 T + A V+ IKQKT DG + +ID+PGH FS+ + Sbjct: 44 TQQIGATYF-------PVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGS 96 Query: 120 RVTDGALVVVDTIEGVCVQTETVLRQALGERIKP-VVVINKVDRALLELQVSKEDLYQTF 178 + + A++VVD + G+ QT LR L ER P VV +NK+DR ++ ++F Sbjct: 97 SLCNIAILVVDIMHGLEPQTIESLR-LLRERKTPFVVALNKIDRLYGWKKIENNGFRESF 155 Query: 179 ARTVESVNVIVSTYADEV 196 A ++V D+V Sbjct: 156 ALQNKAVQNEFRNRLDQV 173 >4N3G-A nrPDB Length = 603 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 90/198 (45%), Gaps = 37/198 (18%) Query: 11 SLMDKVTNVRN--MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGI 68 S M+K N+R+ ++ HVD GK+ L D + Q + + GEA GI Sbjct: 1 SHMNK-DNLRSPICCILGHVDTGKTKLLDKIRQ-----TNVQEGEAG-----------GI 43 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKT-----DGNSFL----INLIDSPGHVDFSSEVTAAL 119 T + A V+ IKQKT DG + +ID+PGH FS+ + Sbjct: 44 TQQIGATYF-------PVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGS 96 Query: 120 RVTDGALVVVDTIEGVCVQTETVLRQALGERIKP-VVVINKVDRALLELQVSKEDLYQTF 178 + + A++VVD + G+ QT LR L ER P VV +NK+DR ++ ++F Sbjct: 97 SLCNIAILVVDIMHGLEPQTIESLR-LLRERKTPFVVALNKIDRLYGWKKIENNGFRESF 155 Query: 179 ARTVESVNVIVSTYADEV 196 A ++V D+V Sbjct: 156 ALQNKAVQNEFRNRLDQV 173 >1G7S-A nrPDB Length = 594 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/143 (30%), Positives = 66/143 (46%), Gaps = 18/143 (12%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 +SV+ HVDHGK+TL D + R +++ +AG GIT A + ++ Sbjct: 8 VSVLGHVDHGKTTLLDHI--RGSAVASREAG--------------GITQHIGATEIPMDV 51 Query: 82 SDEDVKEIKQKTDGNSFLINL--IDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 + + +K L L ID+PGH F++ + D A+++VD EG QT Sbjct: 52 IEGICGDFLKKFSIRETLPGLFFIDTPGHEAFTTLRKRGGALADLAILIVDINEGFKPQT 111 Query: 140 ETVLRQALGERIKPVVVINKVDR 162 + L R VV NK+DR Sbjct: 112 QEALNILRMYRTPFVVAANKIDR 134 >2LKD-A nrPDB Length = 178 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/141 (27%), Positives = 63/141 (44%), Gaps = 32/141 (22%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK+TL D++ R ++ +AG GIT I Y Sbjct: 11 VTIMGHVDHGKTTLLDAI--RHSKVTEQEAG--------------GIT---QHIGAY--- 48 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 + N I +D+PGH F++ +VTD ++VV +GV QT Sbjct: 49 ----------QVTVNDKKITFLDTPGHEAFTTMRARGAQVTDIVILVVAADDGVMPQTVE 98 Query: 142 VLRQALGERIKPVVVINKVDR 162 + A + +V INK+D+ Sbjct: 99 AINHAKAANVPIIVAINKMDK 119 >5IZL-A nrPDB Length = 616 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 64/150 (42%), Gaps = 18/150 (12%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK--------S 72 N+ V+ H+D GK+ L +L + A A F D + +ERGIT+ Sbjct: 29 NVGVLGHIDSGKTALARAL--------STTASTAAF-DKQPQSRERGITLDLGFSCFSVP 79 Query: 73 TAISLYSEMSDEDVKEIKQKTDGNSFL-INLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 L S + + + G L + L+D PGH + ++ D ++V+D Sbjct: 80 LPARLRSSLPEFQAAPEAEPEPGEPLLQVTLVDCPGHASLIRTIIGGAQIIDLMMLVIDV 139 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVD 161 +G+ Q+ L K VVV+NK+D Sbjct: 140 TKGMQTQSAECLVIGQIACQKLVVVLNKID 169 >4ZU9-A nrPDB Length = 582 Score = 45.8 bits (107), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 46/151 (30%), Positives = 70/151 (46%), Gaps = 29/151 (19%) Query: 26 AHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSDED 85 HVDHGK+TL +L GI TD +E++RG++I Y + D + Sbjct: 10 GHVDHGKTTLIKTL---TGI----------DTDRLPEEKKRGLSIDIGFA--YIDFPDIN 54 Query: 86 VKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQ 145 + + +ID PGH F A + G ++VVD EG+ QT LR Sbjct: 55 TR------------LEIIDVPGHERFIKNAIAGICSASGLILVVDPNEGIMPQTIEHLRV 102 Query: 146 ALGERIKP-VVVINKVDRALLEL-QVSKEDL 174 A IK + V+ K+D+ EL +++E+L Sbjct: 103 AKSFGIKHGIAVLTKMDKVDEELAHIAEEEL 133 >4TN1-B nrPDB Length = 345 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/186 (29%), Positives = 81/186 (43%), Gaps = 38/186 (20%) Query: 23 SVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMS 82 ++ HV GK+ L D + Q + + GEA GIT + A Sbjct: 14 CILGHVRTGKTKLLDKIRQ-----TNVQEGEAG-----------GITQQIGATYF----- 52 Query: 83 DEDVKEIKQKT-----DGN------SFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 V+ IKQKT DG LI ID+PGH FS+ + + + A++VVD Sbjct: 53 --PVEAIKQKTAVVNKDGKFEFKVPGLLI--IDTPGHESFSNLRSRGSSLCNIAILVVDI 108 Query: 132 IEGVCVQTETVLRQALGERIKP-VVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVS 190 + G+ QT LR L ER P VV +NK+DR ++ ++FA ++V Sbjct: 109 MHGLEPQTIESLR-LLRERKTPFVVALNKIDRLYGWKKIENNGFRESFALQNKAVQNEFR 167 Query: 191 TYADEV 196 D+V Sbjct: 168 NRLDQV 173 >3PEN-A nrPDB Length = 403 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 34/109 (31%), Positives = 56/109 (51%), Gaps = 12/109 (11%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ V+ HVDHGK+TL ++ GI ++ K G A T+ E + T S S Sbjct: 10 NIGVVGHVDHGKTTLVQAI---TGIWTSKKLGYAE-TNIGVCESCKKPEAYVTEPSCKSC 65 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVV 129 SD++ K +++ I+ ID+PGH + + + + DGA++VV Sbjct: 66 GSDDEPKFLRR--------ISFIDAPGHEVLMATMLSGAALMDGAILVV 106 >4B44-A nrPDB Length = 363 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 61/138 (44%), Gaps = 32/138 (23%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSD 83 ++ HVDHGK+TL D L R I+ +AG GIT Sbjct: 78 IMGHVDHGKTTLLDYL--RKSRIAEKEAG--------------GIT-------------- 107 Query: 84 EDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVL 143 + V + KT + + ID+PGH F++ +V D A++V+ +G+ QTE + Sbjct: 108 QHVGAFEVKTPQGTVV--FIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQTEEAI 165 Query: 144 RQALGERIKPVVVINKVD 161 A K + INK+D Sbjct: 166 AHAKAAGAKLIFAINKID 183 >4KJZ-A nrPDB Length = 473 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 61/138 (44%), Gaps = 32/138 (23%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSD 83 ++ HVDHGK+TL D L R I+ +AG GIT Sbjct: 77 IMGHVDHGKTTLLDYL--RKSRIAEKEAG--------------GIT-------------- 106 Query: 84 EDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVL 143 + V + KT + + ID+PGH F++ +V D A++V+ +G+ QTE + Sbjct: 107 QHVGAFEVKTPQGTVV--FIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQTEEAI 164 Query: 144 RQALGERIKPVVVINKVD 161 A K + INK+D Sbjct: 165 AHAKAAGAKLIFAINKID 182 >1EFM-A nrPDB Length = 379 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/145 (27%), Positives = 62/145 (42%), Gaps = 37/145 (25%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ I HVDHGK+TLT ++ +++ G AR GITI ++ + Sbjct: 13 NVGTIGHVDHGKTTLTAAITT---VLAKTYGGAAR-----------GITINTSHVEY--- 55 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT- 139 D + +D PGH D+ + DGA++VV +G QT Sbjct: 56 -------------DTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTR 102 Query: 140 ETVLRQALGERIKP---VVVINKVD 161 E +L LG ++ +V +NK D Sbjct: 103 EHIL---LGRQVGVPYIIVFLNKCD 124 >1S0U-A nrPDB Length = 408 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/171 (25%), Positives = 79/171 (46%), Gaps = 36/171 (21%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ ++ HVDHGK++LT +L +TD +E RGI+I+ Y++ Sbjct: 10 NIGMVGHVDHGKTSLTKALT-------------GVWTDRHSEELRRGISIRLG----YAD 52 Query: 81 MSDEDVKEIKQKTDG---------NSFL--INLIDSPGHVDFSSEVTAALRVTDGALVVV 129 + T FL ++ +DSPGH + + + + DGA++V+ Sbjct: 53 CEIRKCPQCGTYTTKPRCPNCLAETEFLRRVSFVDSPGHETLMATMLSGASLMDGAILVI 112 Query: 130 DTIEGVCVQTET----VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 E C Q +T + + LG K ++V NK+D L++ + ++E+ Q Sbjct: 113 AANE-PCPQPQTKEHLMALEILGID-KIIIVQNKID--LVDEKQAEENYEQ 159 >3J4J-A nrPDB Length = 569 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 61/138 (44%), Gaps = 32/138 (23%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSD 83 ++ HVDHGK+TL D L R I+ +AG GIT Sbjct: 78 IMGHVDHGKTTLLDYL--RKSRIAEKEAG--------------GIT-------------- 107 Query: 84 EDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVL 143 + V + KT + + ID+PGH F++ +V D A++V+ +G+ QTE + Sbjct: 108 QHVGAFEVKTPQGTVV--FIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQTEEAI 165 Query: 144 RQALGERIKPVVVINKVD 161 A K + INK+D Sbjct: 166 AHAKAAGAKLIFAINKID 183 >3JCN-b nrPDB Length = 890 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/141 (26%), Positives = 67/141 (47%), Gaps = 32/141 (22%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK++L D + R+ +++ +AG GIT A + +E Sbjct: 394 VTIMGHVDHGKTSLLDYI--RSTKVASGEAG--------------GITQHIGAYHVETE- 436 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 + +I +D+PGH F+S + TD ++VV +GV QT Sbjct: 437 ---------------NGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIE 481 Query: 142 VLRQALGERIKPVVVINKVDR 162 ++ A ++ VV +NK+D+ Sbjct: 482 AIQHAKAAQVPVVVAVNKIDK 502 >3P27-A nrPDB Length = 483 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 54/122 (44%), Gaps = 31/122 (25%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAK----------AGEARF-----TDTRKDEQERGI 68 V+ HVD GKSTL L+ I++ ++ G++ F D +E+ERG+ Sbjct: 38 VLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKSSFKFAWIMDQTNEERERGV 97 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVV 128 T+ S S +S T +F I +D+PGH DF + D A++ Sbjct: 98 TV-SICTSHFS-------------THRANFTI--VDAPGHRDFVPNAIMGISQADMAILC 141 Query: 129 VD 130 VD Sbjct: 142 VD 143 >3IZQ-1 nrPDB Length = 611 Score = 40.8 bits (94), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 54/122 (44%), Gaps = 31/122 (25%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAK----------AGEARF-----TDTRKDEQERGI 68 V+ HVD GKSTL L+ I++ ++ G++ F D +E+ERG+ Sbjct: 172 VLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKSSFKFAWIMDQTNEERERGV 231 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVV 128 T+ S S +S T +F I +D+PGH DF + D A++ Sbjct: 232 TV-SICTSHFS-------------THRANFTI--VDAPGHRDFVPNAIMGISQADMAILC 275 Query: 129 VD 130 VD Sbjct: 276 VD 277 >3WBI-A nrPDB Length = 606 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 26/169 (15%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSD 83 ++ HVD GK+ L D + Q + + GEA GIT + A + Sbjct: 14 ILGHVDTGKTKLLDKIRQ-----TNVQGGEAG-----------GITQQIGATYFPIDAIK 57 Query: 84 EDVKEI----KQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 K + KQ D L+ ID+PGH FS+ + + + A++V+D + G+ QT Sbjct: 58 AKTKVMAEYEKQTFDVPGLLV--IDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQT 115 Query: 140 -ETVLRQALGERIKP-VVVINKVDRALLELQVSKEDLYQTFARTVESVN 186 E++ + L +R P VV +NK+DR + +FA+ +V Sbjct: 116 IESI--KLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQ 162 >4V8Y-CP nrPDB Length = 339 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 46/168 (27%), Positives = 76/168 (45%), Gaps = 26/168 (15%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSD 83 ++ HVD GK+ L D + Q + + GEA GIT + A + Sbjct: 10 ILGHVDTGKTKLLDKIRQ-----TNVQGGEAG-----------GITQQIGATYFPIDAIK 53 Query: 84 EDVKEI----KQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 K + KQ D L+ ID+PGH FS+ + + + A++V+D + G+ QT Sbjct: 54 AKTKVMAEYEKQTFDVPGLLV--IDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQT 111 Query: 140 -ETVLRQALGERIKP-VVVINKVDRALLELQVSKEDLYQTFARTVESV 185 E++ + L +R P VV +NK+DR + +FA+ +V Sbjct: 112 IESI--KLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAV 157 >4NCF-A nrPDB Length = 457 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 26/169 (15%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSD 83 ++ HVD GK+ L D + Q + + GEA GIT + A + Sbjct: 15 ILGHVDTGKTKLLDKIRQ-----TNVQGGEAG-----------GITQQIGATYFPIDAIK 58 Query: 84 EDVKEI----KQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 K + KQ D L+ ID+PGH FS+ + + + A++V+D + G+ QT Sbjct: 59 AKTKVMAEYEKQTFDVPGLLV--IDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQT 116 Query: 140 -ETVLRQALGERIKP-VVVINKVDRALLELQVSKEDLYQTFARTVESVN 186 E++ + L +R P VV +NK+DR + +FA+ +V Sbjct: 117 IESI--KLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQ 163 >4V8Z-CV nrPDB Length = 586 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 46/168 (27%), Positives = 76/168 (45%), Gaps = 26/168 (15%) Query: 24 VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSD 83 ++ HVD GK+ L D + Q + + GEA GIT + A + Sbjct: 10 ILGHVDTGKTKLLDKIRQ-----TNVQGGEAG-----------GITQQIGATYFPIDAIK 53 Query: 84 EDVKEI----KQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 K + KQ D L+ ID+PGH FS+ + + + A++V+D + G+ QT Sbjct: 54 AKTKVMAEYEKQTFDVPGLLV--IDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQT 111 Query: 140 -ETVLRQALGERIKP-VVVINKVDRALLELQVSKEDLYQTFARTVESV 185 E++ + L +R P VV +NK+DR + +FA+ +V Sbjct: 112 IESI--KLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAV 157 >5LZD-z nrPDB Length = 614 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 36/122 (29%), Positives = 52/122 (42%), Gaps = 28/122 (22%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++ HVDHGK+TL + I+ A D +E++RG+TI Y+ Sbjct: 3 IATAGHVDHGKTTLLQA-------ITGVNA------DRLPEEKKRGMTIDLG----YAYW 45 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 D + + ID PGH F S + A + D AL+VV +GV QT Sbjct: 46 PQPDGR-----------VPGFIDVPGHEKFLSNMLAGVGGIDHALLVVACDDGVMAQTRE 94 Query: 142 VL 143 L Sbjct: 95 HL 96 >3J81-k nrPDB Length = 527 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 49/165 (29%), Positives = 75/165 (45%), Gaps = 38/165 (23%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK--STAISLY 78 N+ I HV HGKST+ ++ +G+ + RF KDE ER ITIK +Y Sbjct: 102 NIGTIGHVAHGKSTVVRAI---SGVQT------VRF----KDELERNITIKLGYANAKIY 148 Query: 79 --------------SEMSDEDVKEIKQK--TDGNSFL---INLIDSPGHVDFSSEVTAAL 119 S SD+++ Q+ G L ++ +D PGH S + + Sbjct: 149 KCQEPTCPEPDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSGA 208 Query: 120 RVTDGALVVVDTIEGVCVQTETVLRQALGE--RIKPVVVI-NKVD 161 V D AL+++ E C Q +T A E ++K V+++ NKVD Sbjct: 209 AVMDAALLLIAGNES-CPQPQTSEHLAAIEIMKLKHVIILQNKVD 252 >1ZO1-I nrPDB Length = 501 Score = 38.9 bits (89), Expect = 0.010, Method: Compositional matrix adjust. Identities = 36/141 (25%), Positives = 67/141 (47%), Gaps = 32/141 (22%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK++L + + R+ +++ +AG GIT A + +E Sbjct: 7 VTIMGHVDHGKTSLLEYI--RSTKVASGEAG--------------GITQHIGAYHVETE- 49 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 + +I +D+PGH F+S + TD ++VV +GV QT Sbjct: 50 ---------------NGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIE 94 Query: 142 VLRQALGERIKPVVVINKVDR 162 ++ A ++ VV +NK+D+ Sbjct: 95 AIQHAKAAQVPVVVAVNKIDK 115 >1ZUN-B nrPDB Length = 434 Score = 38.9 bits (89), Expect = 0.010, Method: Compositional matrix adjust. Identities = 46/156 (29%), Positives = 67/156 (42%), Gaps = 38/156 (24%) Query: 26 AHVDHGKSTLTDSLVQRAGII----------SAAKAGE-------ARFTDTRKDEQERGI 68 +VD GKSTL L+ + +I + K+G A D + E+E+GI Sbjct: 31 GNVDDGKSTLIGRLLHDSKMIYEDHLEAITRDSKKSGTTGDDVDLALLVDGLQAEREQGI 90 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVV 128 TI DV T F+I D+PGH ++ + D A+++ Sbjct: 91 TI--------------DVAYRYFSTAKRKFII--ADTPGHEQYTRNMATGASTCDLAIIL 134 Query: 129 VDTIEGVCVQT--ETVLRQALGERIKPVVV-INKVD 161 VD GV QT + + LG IK +VV INK+D Sbjct: 135 VDARYGVQTQTRRHSYIASLLG--IKHIVVAINKMD 168 >6FEC-S nrPDB Length = 422 Score = 37.7 bits (86), Expect = 0.021, Method: Compositional matrix adjust. Identities = 52/184 (28%), Positives = 80/184 (43%), Gaps = 42/184 (22%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK--------- 71 N+ I HV HGKST+ ++ +G+ + RF K+E ER ITIK Sbjct: 5 NIGTIGHVAHGKSTVVKAI---SGVHT------VRF----KNELERNITIKLGYANAKIY 51 Query: 72 ----------STAISLYSEMSDEDVKEIKQKTDGNSFL---INLIDSPGHVDFSSEVTAA 118 S S DE +I T GN L ++ +D PGH + + Sbjct: 52 KLDDPSCPRPECYRSCGSSTPDEFPTDIP-GTKGNFKLVRHVSFVDCPGHDILMATMLNG 110 Query: 119 LRVTDGALVVVDTIEGVCVQTETVLRQALGE--RIKPVVVI-NKVDRALLELQVSKEDLY 175 V D AL+++ E C Q +T A E ++K ++++ NK+D L++ +KE Sbjct: 111 AAVMDAALLLIAGNES-CPQPQTSEHLAAIEIMKLKHILILQNKID--LVKESQAKEQYE 167 Query: 176 QTFA 179 Q A Sbjct: 168 QILA 171 >6O81-S nrPDB Length = 472 Score = 37.4 bits (85), Expect = 0.024, Method: Compositional matrix adjust. Identities = 52/184 (28%), Positives = 80/184 (43%), Gaps = 42/184 (22%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK--------- 71 N+ I HV HGKST+ ++ +G+ + RF K+E ER ITIK Sbjct: 43 NIGTIGHVAHGKSTVVKAI---SGVHT------VRF----KNELERNITIKLGYANAKIY 89 Query: 72 ----------STAISLYSEMSDEDVKEIKQKTDGNSFL---INLIDSPGHVDFSSEVTAA 118 S S DE +I T GN L ++ +D PGH + + Sbjct: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIP-GTKGNFKLVRHVSFVDCPGHDILMATMLNG 148 Query: 119 LRVTDGALVVVDTIEGVCVQTETVLRQALGE--RIKPVVVI-NKVDRALLELQVSKEDLY 175 V D AL+++ E C Q +T A E ++K ++++ NK+D L++ +KE Sbjct: 149 AAVMDAALLLIAGNES-CPQPQTSEHLAAIEIMKLKHILILQNKID--LVKESQAKEQYE 205 Query: 176 QTFA 179 Q A Sbjct: 206 QILA 209 >1R5O-A nrPDB Length = 467 Score = 36.2 bits (82), Expect = 0.058, Method: Compositional matrix adjust. Identities = 80/374 (21%), Positives = 149/374 (39%), Gaps = 86/374 (22%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGEARF-----TDTRKDEQE 65 N+ I HVD GKSTL +++ G++ A +AG+ + D+ +E+E Sbjct: 45 NIVFIGHVDAGKSTLGGNILFLTGMVDKRTMEKIEREAKEAGKESWYLSWALDSTSEERE 104 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 +G T+ +V +T+ F +L+D+PGH + + + D Sbjct: 105 KGKTV--------------EVGRAYFETEHRRF--SLLDAPGHKGYVTNMINGASQADIG 148 Query: 126 LVVVDTIEGVC---------VQTETVLRQALGERIKPVVVINKVDRALLELQVSKE---- 172 ++V+ G + VL + G VVVINK+D +Q S+E Sbjct: 149 VLVISARRGEFEAGFERGGQTREHAVLARTQGIN-HLVVVINKMDEP--SVQWSEERYKE 205 Query: 173 --DLYQTFARTVESVN-------VIVSTYADEVLGDVQVYPARGTVAFGSGLHGW--AFT 221 D F R V N + VS Y + + D S + W + Sbjct: 206 CVDKLSMFLRRVAGYNSKTDVKYMPVSAYTGQNVKD----------RVDSSVCPWYQGPS 255 Query: 222 IRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGK----PLERAFNMFI 277 + ++ +D ++R F P K+ + T EGK +++ N+ + Sbjct: 256 LLEY---------LDSMTHLERKVNAPFIMPIASKYKDLGTILEGKIEAGSIKKNSNVLV 306 Query: 278 LDPIFRLF--TAIMNFKKDEI--PVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADA 333 + PI + TAI + +EI + +++ + ++GD+ D++ +L Sbjct: 307 M-PINQTLEVTAIYDEADEEISSSICGDQVRLRVRGDDSDVQTGYVLTSTKNPVHATTRF 365 Query: 334 LLEMIVLHLPSPVT 347 + ++ +L LPS +T Sbjct: 366 IAQIAILELPSILT 379 >3JZY-A nrPDB Length = 510 Score = 33.1 bits (74), Expect = 0.56, Method: Compositional matrix adjust. Identities = 14/52 (26%), Positives = 27/52 (51%) Query: 25 IAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAIS 76 I+H+D + TD++ +R + KA ++ DT K ++E+ +S S Sbjct: 333 ISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKQREKAYQARSQKTS 384 >5LZT-jj nrPDB Length = 637 Score = 32.7 bits (73), Expect = 0.72, Method: Compositional matrix adjust. Identities = 31/118 (26%), Positives = 52/118 (44%), Gaps = 9/118 (7%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ I HVD GKST+ ++ G++ K ++ K E+ R S A+ E Sbjct: 214 NVVFIGHVDAGKSTIGGQIMYLTGMVD--KRTLEKYEREAK-EKNRETWYLSWALDTNQE 270 Query: 81 MSDE----DVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 D+ +V +T+ F I +D+PGH F + D A++V+ +G Sbjct: 271 ERDKGKTVEVGRAYFETEKKHFTI--LDAPGHKSFVPNMIGGASQADLAVLVISARKG 326 >4D61-i nrPDB Length = 426 Score = 32.7 bits (73), Expect = 0.74, Method: Compositional matrix adjust. Identities = 31/118 (26%), Positives = 52/118 (44%), Gaps = 9/118 (7%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ I HVD GKST+ ++ G++ K ++ K E+ R S A+ E Sbjct: 5 NVVFIGHVDAGKSTIGGQIMYLTGMVD--KRTLEKYEREAK-EKNRETWYLSWALDTNQE 61 Query: 81 MSDE----DVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 D+ +V +T+ F I +D+PGH F + D A++V+ +G Sbjct: 62 ERDKGKTVEVGRAYFETEKKHFTI--LDAPGHKSFVPNMIGGASQADLAVLVISARKG 117 >3E3X-A nrPDB Length = 332 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 43/109 (39%), Gaps = 17/109 (15%) Query: 705 IIPTMRRATYAGFLLA-----------DPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQ 753 +I MRR GF LA D ++ EP V I E+ GGI + ++G+ Sbjct: 96 LIENMRRE---GFELAVSRPEVIIKEEDGQLMEPFETVTIDVMEEHQGGIMENIGLRKGE 152 Query: 754 VVSEEQRP-GTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHW 801 + ++ P G + +P GF E T G FDH+ Sbjct: 153 L--KDMAPDGKGRVRMDFIMPSRGLIGFQTEFMTLTSGSGLLYHTFDHY 199 >4CRN-P nrPDB Length = 430 Score = 32.0 bits (71), Expect = 1.2, Method: Compositional matrix adjust. Identities = 28/113 (24%), Positives = 51/113 (45%), Gaps = 7/113 (6%) Query: 25 IAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSDE 84 + HVD GKST+ +L+ G S K ++ KD +G + + E +D Sbjct: 11 MGHVDAGKSTMGGNLLYLTG--SVDKRTIEKYEREAKDAGRQGWYLSWVMDTNKEERNDG 68 Query: 85 DVKEIKQ---KTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 E+ + +T+ + I +D+PGH + SE+ D ++V+ +G Sbjct: 69 KTIEVGKAYFETEKRRYTI--LDAPGHKMYVSEMIGGASQADVGVLVISARKG 119 >4ZCK-A nrPDB Length = 332 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 23/36 (63%), Gaps = 2/36 (5%) Query: 530 VAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRE 565 V+G GELHL + ++++ + G L +S P V +RE Sbjct: 87 VSGRGELHLSVLIENMRRE--GFELAVSRPKVIFRE 120 >2HDN-B nrPDB Length = 335 Score = 30.8 bits (68), Expect = 2.6, Method: Compositional matrix adjust. Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 7/63 (11%) Query: 103 IDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT-ETVLRQALGERIKP---VVVIN 158 +D PGH D+ + DGA++VV +G QT E +L LG ++ +V +N Sbjct: 21 VDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHIL---LGRQVGVPYIIVFLN 77 Query: 159 KVD 161 K D Sbjct: 78 KCD 80 >5EG9-A nrPDB Length = 183 Score = 30.4 bits (67), Expect = 3.0, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 17/95 (17%) Query: 152 KPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAF 211 + ++ K R L++L VS D Q+ A + ++ ++ E D + RG + F Sbjct: 73 RATAILRKATRRLIQLIVSGRD-EQSIAEAI----IVAMVFSQE---DCMIKAVRGDLNF 124 Query: 212 GSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWG 246 GSGL+ +R F AK++ + WG Sbjct: 125 GSGLNPMHQLLRHFQ---------KDAKVLFQNWG 150 >4CB7-A nrPDB Length = 163 Score = 30.4 bits (67), Expect = 3.1, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 17/95 (17%) Query: 152 KPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAF 211 + ++ K R L++L VS D Q+ A + ++ ++ E D + RG + F Sbjct: 53 RATAILRKATRRLIQLIVSGRD-EQSIAEAI----IVAMVFSQE---DCMIKAVRGDLNF 104 Query: 212 GSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWG 246 GSGL+ +R F AK++ + WG Sbjct: 105 GSGLNPMHQLLRHFQ---------KDAKVLFQNWG 130 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2P8Y-T nrPDB 1135 0.0 4V6W-Az nrPDB 1109 0.0 6MTD-v nrPDB 1062 0.0 6ID0-C nrPDB 960 0.0 3JB9-B nrPDB 916 0.0 5H7J-A nrPDB 685 0.0 6N0I-A nrPDB 662 0.0 4FN5-A nrPDB 658 0.0 6NOT-A nrPDB 637 0.0 4WQY-BZ nrPDB 618 e-177 4V7D-BZ nrPDB 617 e-177 3ZZ0-A nrPDB 614 e-176 1WDT-A nrPDB 447 e-126 6BK7-A nrPDB 343 3e-94 5TY0-A nrPDB 339 2e-93 2MZW-A nrPDB 331 1e-90 5H7K-A nrPDB 326 2e-89 5VH6-A nrPDB 324 7e-89 6B8D-A nrPDB 322 5e-88 5TV2-A nrPDB 314 1e-85 3TR5-A nrPDB 194 2e-49 4V89-AW nrPDB 189 4e-48 3VQT-A nrPDB 185 6e-47 4J0Q-A nrPDB 175 9e-44 4ZV4-A nrPDB 175 1e-43 4V5G-AZ nrPDB 174 1e-43 5W7Q-A nrPDB 172 8e-43 5W75-A nrPDB 171 1e-42 3CB4-D nrPDB 170 2e-42 3MMP-A nrPDB 169 4e-42 5W76-A nrPDB 169 5e-42 4V6V-A1 nrPDB 168 7e-42 5KCS-1w nrPDB 167 1e-41 6MIJ-A nrPDB 167 3e-41 5A9Z-CA nrPDB 166 3e-41 1MJ1-A nrPDB 166 4e-41 5J8B-z nrPDB 166 4e-41 1D2E-A nrPDB 165 1e-40 2YWH-A nrPDB 160 3e-39 5IMR-C nrPDB 156 2e-38 4NCL-A nrPDB 156 4e-38 4N3G-A nrPDB 156 5e-38 1EFM-A nrPDB 152 5e-37 4TN1-B nrPDB 151 9e-37 1G7S-A nrPDB 141 1e-33 3WXM-A nrPDB 141 2e-33 4UJC-AB nrPDB 138 7e-33 1JNY-A nrPDB 138 7e-33 3IZY-P nrPDB 137 2e-32 6GB2-BC nrPDB 136 3e-32 4C0S-A nrPDB 136 5e-32 2LKD-A nrPDB 135 6e-32 2B7C-A nrPDB 135 7e-32 5FG3-A nrPDB 134 1e-31 5LZS-jj nrPDB 134 1e-31 3WY9-A nrPDB 134 2e-31 5YT0-A nrPDB 133 3e-31 4AC9-A nrPDB 131 8e-31 2D74-A nrPDB 131 1e-30 1S0U-A nrPDB 127 2e-29 3PEN-A nrPDB 126 3e-29 4ZU9-A nrPDB 125 8e-29 5IZL-A nrPDB 122 5e-28 5LZY-jj nrPDB 122 6e-28 3MCA-A nrPDB 120 2e-27 3J4J-A nrPDB 118 1e-26 4KJZ-A nrPDB 117 2e-26 4B44-A nrPDB 116 4e-26 3JCN-b nrPDB 116 4e-26 Sequences not found previously or not previously below threshold: 4NCF-A nrPDB 136 3e-32 4V8Y-CP nrPDB 135 1e-31 3WBI-A nrPDB 133 3e-31 4V8Z-CV nrPDB 132 8e-31 1ZO1-I nrPDB 118 1e-26 5LZD-z nrPDB 115 8e-26 2HDN-B nrPDB 113 5e-25 4D61-i nrPDB 109 4e-24 1R5O-A nrPDB 108 1e-23 5LZT-jj nrPDB 108 1e-23 1ZUN-B nrPDB 106 5e-23 3P27-A nrPDB 103 4e-22 3IZQ-1 nrPDB 103 4e-22 6FEC-S nrPDB 99 6e-21 6O81-S nrPDB 99 9e-21 3J81-k nrPDB 97 3e-20 4CRN-P nrPDB 85 1e-16 3E3X-A nrPDB 57 4e-08 4ZCK-A nrPDB 56 7e-08 5DN8-A nrPDB 50 3e-06 3R9W-A nrPDB 48 1e-05 5MVF-A nrPDB 48 1e-05 5G06-P nrPDB 48 2e-05 4ZKD-A nrPDB 48 2e-05 2QTH-A nrPDB 48 2e-05 4IXM-A nrPDB 47 4e-05 3IEU-A nrPDB 46 8e-05 3J8G-X nrPDB 45 1e-04 1WF3-A nrPDB 43 5e-04 5LAD-A nrPDB 43 7e-04 4HI0-E nrPDB 43 8e-04 1MKY-A nrPDB 42 9e-04 3GEH-A nrPDB 41 0.002 2WIC-A nrPDB 40 0.003 5KH0-A nrPDB 40 0.005 5L94-A nrPDB 40 0.005 2E87-A nrPDB 40 0.007 3PIR-A nrPDB 39 0.008 4DCU-A nrPDB 39 0.009 5X4B-A nrPDB 39 0.009 2CXX-A nrPDB 39 0.010 3A1U-A nrPDB 39 0.011 5ZZM-A nrPDB 38 0.014 4V0N-A nrPDB 38 0.024 2QPT-A nrPDB 37 0.028 4R98-A nrPDB 37 0.036 2WSM-A nrPDB 37 0.037 5CM8-B nrPDB 37 0.039 2FN4-A nrPDB 36 0.049 5ZLU-EE nrPDB 36 0.049 5WDR-A nrPDB 36 0.098 1XZP-A nrPDB 35 0.10 1T9H-A nrPDB 35 0.12 1Z22-A nrPDB 35 0.13 2GAO-A nrPDB 35 0.13 5J40-A nrPDB 35 0.16 2YKR-W nrPDB 34 0.26 5NO4-Z nrPDB 34 0.28 3A1W-A nrPDB 34 0.29 2ERY-A nrPDB 34 0.31 1U0L-A nrPDB 34 0.31 4BAS-A nrPDB 34 0.32 3CUE-F nrPDB 33 0.39 1YZN-A nrPDB 33 0.39 4GDF-A nrPDB 33 0.44 1SVL-A nrPDB 33 0.44 2DYK-A nrPDB 33 0.47 1F6B-A nrPDB 33 0.48 6GNI-B nrPDB 33 0.50 1M2O-B nrPDB 33 0.50 6NB0-A nrPDB 33 0.52 2G77-B nrPDB 33 0.53 1Z06-A nrPDB 33 0.53 3CLV-A nrPDB 33 0.55 3RAP-R nrPDB 33 0.60 5CLL-A nrPDB 33 0.61 5WDQ-A nrPDB 33 0.63 2EP7-A nrPDB 33 0.63 4M8N-E nrPDB 33 0.64 4DXA-A nrPDB 33 0.64 5UWI-A nrPDB 33 0.66 2N1B-A nrPDB 33 0.66 2OCB-A nrPDB 33 0.68 5FHF-A nrPDB 33 0.71 4WA7-A nrPDB 33 0.80 1R9X-A nrPDB 32 0.87 2KE5-A nrPDB 32 0.94 5L3S-A nrPDB 32 0.95 1QZX-A nrPDB 32 1.1 3CON-A nrPDB 32 1.3 4PHF-A nrPDB 31 1.5 5UHV-A nrPDB 31 1.5 6FVU-I nrPDB 31 1.6 4FMC-F nrPDB 31 1.7 3L0I-B nrPDB 31 1.7 3JCP-I nrPDB 31 1.7 3OES-A nrPDB 31 1.8 4MKI-B nrPDB 31 1.9 3PNS-A nrPDB 31 3.0 3T5G-A nrPDB 30 3.3 4Z54-A nrPDB 30 3.7 1PUJ-A nrPDB 30 3.9 5B3F-A nrPDB 30 4.8 4JYC-A nrPDB 30 5.3 1TMF-3 nrPDB 29 6.5 >2P8Y-T nrPDB Length = 842 Score = 1135 bits (2935), Expect = 0.0, Method: Composition-based stats. Identities = 842/842 (100%), Positives = 842/842 (100%) Query: 1 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTR 60 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTR Sbjct: 1 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTR 60 Query: 61 KDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALR 120 KDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALR Sbjct: 61 KDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALR 120 Query: 121 VTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR 180 VTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR Sbjct: 121 VTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR 180 Query: 181 TVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKM 240 TVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKM Sbjct: 181 TVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKM 240 Query: 241 MDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLL 300 MDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLL Sbjct: 241 MDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLL 300 Query: 301 EKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGP 360 EKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGP Sbjct: 301 EKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGP 360 Query: 361 ADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVP 420 ADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVP Sbjct: 361 ADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVP 420 Query: 421 GKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKV 480 GKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKV Sbjct: 421 GKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKV 480 Query: 481 MKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEI 540 MKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEI Sbjct: 481 MKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEI 540 Query: 541 CLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLA 600 CLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLA Sbjct: 541 CLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLA 600 Query: 601 IENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIK 660 IENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIK Sbjct: 601 IENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIK 660 Query: 661 DSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLA 720 DSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLA Sbjct: 661 DSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLA 720 Query: 721 DPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGF 780 DPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGF Sbjct: 721 DPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGF 780 Query: 781 TGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYD 840 TGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYD Sbjct: 781 TGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYD 840 Query: 841 KL 842 KL Sbjct: 841 KL 842 >4V6W-Az nrPDB Length = 844 Score = 1109 bits (2868), Expect = 0.0, Method: Composition-based stats. Identities = 568/848 (66%), Positives = 682/848 (80%), Gaps = 10/848 (1%) Query: 1 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTR 60 MV FTVD++R LMDK N+RNMSVIAHVDHGKSTLTDSLV +AGII+ AKAGE RFTDTR Sbjct: 1 MVNFTVDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTR 60 Query: 61 KDEQERGITIKSTAISLYSEMSDEDVKEIKQK----TDGNSFLINLIDSPGHVDFSSEVT 116 KDEQER ITIKSTAIS+Y E+ ++D+ I + FLINLIDSPGHVDFSSEVT Sbjct: 61 KDEQERCITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVT 120 Query: 117 AALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 AALRVTDGALVVVD + GVCVQTETVLRQA+ ERIKP++ +NK+DRALLELQ+ E+LYQ Sbjct: 121 AALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQ 180 Query: 177 TFARTVESVNVIVSTYADE--VLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFG 234 TF R VE+VNVI++TY D+ +G+V+V P++G+V FGSGLHGWAFT++QF+ Y++KF Sbjct: 181 TFQRIVENVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKFK 240 Query: 235 VDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKD 294 +D K+M+RLWG++FFN KTKKW K +A+ K R+F M+ILDPI+++F AIMN+KK+ Sbjct: 241 IDVVKLMNRLWGENFFNAKTKKW-QKQKEADNK---RSFCMYILDPIYKVFDAIMNYKKE 296 Query: 295 EIPVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAE 354 EI LLEK+ + LK ++KD +GKALLK VMR +LPA +ALL+MI +HLPSPV AQ YR E Sbjct: 297 EIGTLLEKIGVTLKHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRME 356 Query: 355 QLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQ 414 LYEGP DD IA+K+CDP LM+Y+SKMVPTSDKGRFYAFGRVFAG V +GQK RI Sbjct: 357 MLYEGPHDDEAAIAVKSCDPDGPLMMYISKMVPTSDKGRFYAFGRVFAGKVATGQKCRIM 416 Query: 415 GPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSET 474 GPNY PGKK+DL+ KAIQR +LMMGR+VE I+D P+GNI GLVG+DQFL+KTGT+TT + Sbjct: 417 GPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKD 476 Query: 475 AHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTG 534 AHNMKVMKFSVSPVV+VAVE KN DLPKLVEGLKRL+KSDP V + ESGEHI+AG G Sbjct: 477 AHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAG 536 Query: 535 ELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPID 594 ELHLEICL+DLE DHA +PLK S PVV+YRETV ES Q LSKSPNKHNR+ +KA P+ Sbjct: 537 ELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLSKSPNKHNRLLMKALPMP 596 Query: 595 EEVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQ 654 + + I+NG ++ +D+FKARAR +++ Y +DVT+ARKIWCFGPDG GPN ++D TK+VQ Sbjct: 597 DGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGPDGTGPNFILDCTKSVQ 656 Query: 655 YLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATY 714 YL+EIKDSVVA FQWA+KEG + E +R VR NI DVTLHADAIHRGGGQIIPT RR Y Sbjct: 657 YLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIHRGGGQIIPTTRRCLY 716 Query: 715 AGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPV 774 A + A P++ EPV+L EIQCPE AVGGIY VLN++RG V E Q GTP+F VKAYLPV Sbjct: 717 AAAITAKPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKAYLPV 776 Query: 775 NESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPG 834 NESFGFT +LR TGGQAFPQ VFDHW L DP +P+SK IV RKR G+KE +P Sbjct: 777 NESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPSEPSSKPYAIVQDTRKRKGLKEGLPD 836 Query: 835 WQEYYDKL 842 +Y DKL Sbjct: 837 LSQYLDKL 844 >6MTD-v nrPDB Length = 839 Score = 1062 bits (2747), Expect = 0.0, Method: Composition-based stats. Identities = 550/857 (64%), Positives = 651/857 (75%), Gaps = 34/857 (3%) Query: 2 VAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRK 61 V FTVDQ+R++MDK N+RNMSVIAHVDHGKSTLTDSLV +AGII+ Sbjct: 1 VNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIA-------------- 46 Query: 62 DEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRV 121 R ITIKSTAISL+ E+S+ D+ IKQ DG FLINLIDSPGHVDFSSEVTAALRV Sbjct: 47 ----RCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRV 102 Query: 122 TDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFART 181 TDGALVVVD + GVCVQTETVLRQA+ ERIKPV+++NK+DRALLELQ+ E+LYQTF R Sbjct: 103 TDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRI 162 Query: 182 VESVNVIVSTYADE---VLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVD-- 236 VE+VNVI+STY + +G++ + P GTV FGSGLHGWAFT++QFA Y KF Sbjct: 163 VENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGE 222 Query: 237 -----------KAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLF 285 MM +LWGD +F+P K++ T EGK L R F ILDPIF++F Sbjct: 223 GQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVF 282 Query: 286 TAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSP 345 AIMNFKK+E L+EKL+I L ++KD EGK LLK VMR++LPA DALL+MI +HLPSP Sbjct: 283 DAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSP 342 Query: 346 VTAQAYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTV 405 VTAQ YR E LYEGP DD + IK+CDPK LM+Y+SKMVPTSDKGRFYAFGRVF+G V Sbjct: 343 VTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLV 402 Query: 406 KSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLK 465 +G KVRI GPNY PGKK+DL++K IQR +LMMGR+VEPI+D P GNI+GLVG+DQFL+K Sbjct: 403 STGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVK 462 Query: 466 TGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSES 525 TGT+TT E AHNM+VMKFSVSPVV+VAVE KN DLPKLVEGLKRL+KSDP V + ES Sbjct: 463 TGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEES 522 Query: 526 GEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNR 585 GEHI+AG GELHLEICL+DLE DHA +P+K S PVV+YRETV ES+ LSKSPNKHNR Sbjct: 523 GEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNR 582 Query: 586 IYLKAEPIDEEVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNL 645 +Y+KA P + ++ I+ G ++ R + K RAR +A+ Y WDV +ARKIWCFGPDG GPN+ Sbjct: 583 LYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNI 642 Query: 646 VIDQTKAVQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQI 705 + D TK VQYL+EIKDSVVA FQWATKEG + E MR VR ++ DVTLHADAIHRGGGQI Sbjct: 643 LTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQI 702 Query: 706 IPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPL 765 IPT RR YA L A P++ EP++LVEIQCPEQ VGGIY VLN+KRG V E Q GTP+ Sbjct: 703 IPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPM 762 Query: 766 FTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKR 825 F VKAYLPVNESFGFT +LR TGGQAFPQ VFDHW L DP D +S+ ++V RKR Sbjct: 763 FVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKR 822 Query: 826 HGMKEEVPGWQEYYDKL 842 G+KE +P + DKL Sbjct: 823 KGLKEGIPALDNFLDKL 839 >6ID0-C nrPDB Length = 972 Score = 960 bits (2481), Expect = 0.0, Method: Composition-based stats. Identities = 314/861 (36%), Positives = 503/861 (58%), Gaps = 38/861 (4%) Query: 1 MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGI-ISAAKAGEARFTDT 59 + + +D + LMD +RN+++ H+ HGK+ D L+++ I + +TD Sbjct: 111 VTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDI 170 Query: 60 RKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAAL 119 EQERG+ IKST +++ + T G S+L N++D+PGHV+FS EVTA L Sbjct: 171 LFTEQERGVGIKSTPVTV-----------VLPDTKGKSYLFNIMDTPGHVNFSDEVTAGL 219 Query: 120 RVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFA 179 R++DG ++ +D EGV + TE +++ A+ ER+ V INK+DR +LEL++ D Y Sbjct: 220 RISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLR 279 Query: 180 RTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFG-VDKA 238 V+ VN ++S Y+ + ++ + P G V F S + FT+ FA YA FG ++ Sbjct: 280 HIVDEVNGLISMYSTD--ENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQ 337 Query: 239 KMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPV 298 + RLWGD +FNPKT+K+T K A +R+F FIL+P++++ ++ +P Sbjct: 338 EFAKRLWGDIYFNPKTRKFTKK---APTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPR 394 Query: 299 LLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYE 358 L++L I L +E L + LL++V +KF ++M V H+PSP + E Y Sbjct: 395 TLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYT 454 Query: 359 GPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNY 418 G D A+ +CDP LM + +KM T D +F+AFGRV +GT+ +GQ V++ G NY Sbjct: 455 GGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENY 514 Query: 419 VPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTS---ETA 475 ++D I + R+ + + R+ ++ PAGN + + G+DQ ++KT T+T E A Sbjct: 515 TLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEA 574 Query: 476 HNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGE 535 + +KF+ + V+++AVE N ++LPK+++GL++++KS P + T + ESGEH++ GTGE Sbjct: 575 QIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGE 634 Query: 536 LHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDE 595 L+L+ + DL ++ + +K++ PVV + ETV SS +++PNK N+I + AEP+++ Sbjct: 635 LYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEK 694 Query: 596 EVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQ- 654 ++ IEN ++ + K Y WD+ AR IW FGPD GPN+++D T + Sbjct: 695 GLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEV 754 Query: 655 ---YLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRR 711 L +KDS+V FQW T+EGP+ E +R+V+ ILD + + +HRGGGQIIPT RR Sbjct: 755 DKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARR 814 Query: 712 ATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAY 771 Y+ FL+A P++ EP + VE+Q P V +Y+VL ++RG V + PG+PL+T+KA+ Sbjct: 815 VVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAF 874 Query: 772 LPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPT------------SKAGEIV 819 +P +SFGF +LR T GQAF VF HW + DPLD + A E + Sbjct: 875 IPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFM 934 Query: 820 LAARKRHGMKEEVPGWQEYYD 840 + R+R G+ E+V +++D Sbjct: 935 IKTRRRKGLSEDV-SISKFFD 954 >3JB9-B nrPDB Length = 984 Score = 916 bits (2368), Expect = 0.0, Method: Composition-based stats. Identities = 299/863 (34%), Positives = 474/863 (54%), Gaps = 40/863 (4%) Query: 2 VAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGI-ISAAKAGEARFTDTR 60 + + + L+ +VR+ V H+ HGKS L D LV K R+TDT Sbjct: 124 TVYKKEFLFGLLTGTDDVRSFIVAGHLHHGKSALLDLLVYYTHPDTKPPKRRSLRYTDTH 183 Query: 61 KDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALR 120 E+ER ++IKST ++L G +F ID+PGHVDF EV A + Sbjct: 184 YLERERVMSIKSTPLTLA-----------VSDMKGKTFAFQCIDTPGHVDFVDEVAAPMA 232 Query: 121 VTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR 180 ++DG ++VVD IEGV + T +++ A+ + V+V+NKVDR +LEL++ D Y Sbjct: 233 ISDGVVLVVDVIEGVMINTTRIIKHAILHDMPIVLVLNKVDRLILELRLPPNDAYHKLRH 292 Query: 181 TVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFG-VDKAK 239 ++ VN + + ++ +V P G V F S G+ FT+ FA Y + G +D Sbjct: 293 VIDEVNDNICQISKDL--KYRVSPELGNVCFASCDLGYCFTLSSFAKLYIDRHGGIDVDL 350 Query: 240 MMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVL 299 RLWGD +F+ KT+K+ + D G R+F FIL+P+++L T ++ + +++ Sbjct: 351 FSKRLWGDIYFDSKTRKFAKQSLDGSGV---RSFVHFILEPLYKLHTLTISDEAEKLKKH 407 Query: 300 LEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEG 359 L +I LK + L+ K LL+++ F + + H+PSP A +A Q Y G Sbjct: 408 LSSFQIYLKPKDYLLDPKPLLQLICASFFGFPVGFVNAVTRHIPSPRENAARKASQSYIG 467 Query: 360 PADDANCIAIKNC--DPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPN 417 P + + AI + A L+++V+K+ T D FYAF RV++G VK GQKV++ G N Sbjct: 468 PINSSIGKAILEMSREESAPLVMHVTKLYNTVDANNFYAFARVYSGQVKKGQKVKVLGEN 527 Query: 418 YVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTS---ET 474 Y ++D+ + I + + R+ +D AG ++ L G+D + KT T+ + + Sbjct: 528 YSLEDEEDMVVAHIAEICVPCARYRLHVDGAVAGMLVLLGGVDNSISKTATIVSDNLKDD 587 Query: 475 AHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTG 534 + + + V +VAVE N ++LPKL++GL++ +KS P +T + ESGEH + GTG Sbjct: 588 PYIFRPIAHMSESVFKVAVEPHNPSELPKLLDGLRKTNKSYPLSITKVEESGEHTIFGTG 647 Query: 535 ELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPID 594 E++++ L DL ++ + +++S PV + ET SS S +PNK NRI + EP++ Sbjct: 648 EMYMDCLLYDLRTLYSEIEIRVSDPVARFCETAVDTSSIKCFSDTPNKKNRITMVVEPLE 707 Query: 595 EEVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAV- 653 + +S IENG +N K + +Y WD+ +R IW FGPD G N++ D T + Sbjct: 708 KGISNDIENGKVNINWPQKRISEFFQKNYDWDLLASRSIWAFGPDDRGTNILRDDTLSTD 767 Query: 654 ---QYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMR 710 L+ +K+ + FQW T+EGP+ E +R+V ++DV L + I+RGGGQIIPT R Sbjct: 768 VDKNVLNSVKEYIKQGFQWGTREGPLCDETIRNVNFRLMDVVLAPEQIYRGGGQIIPTAR 827 Query: 711 RATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKA 770 R Y+ FL A P++ EPV++VE+ P ++ IY +L ++RG V+ + RPG+PL+ V+A Sbjct: 828 RVCYSSFLTASPRLMEPVYMVEVHAPADSLPIIYDLLTRRRGHVLQDIPRPGSPLYLVRA 887 Query: 771 YLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSK------------AGEI 818 +PV +S GF +LR T GQA QMVFDHW + DPLD + K A + Sbjct: 888 LIPVIDSCGFETDLRVHTQGQAMCQMVFDHWQVVPGDPLDKSIKPKPLEPARGSDLARDF 947 Query: 819 VLAARKRHGMKEEVPGWQEYYDK 841 ++ R+R G+ E+V Y+D+ Sbjct: 948 LIKTRRRKGLVEDV-STTRYFDQ 969 >5H7J-A nrPDB Length = 743 Score = 685 bits (1767), Expect = 0.0, Method: Composition-based stats. Identities = 274/809 (33%), Positives = 414/809 (51%), Gaps = 120/809 (14%) Query: 6 VDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQE 65 + +++ LM + +RN+ + AH+DHGK+TL+D+L+ AG+IS AG+ D + EQ Sbjct: 11 IAKIKELMLQPERIRNIGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQLVLDFDEQEQA 70 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RGITI + +S+ +G +LINLID+PGHVDF +VT A+R DG Sbjct: 71 RGITINAANVSMV------------HNYEGKDYLINLIDTPGHVDFGGDVTRAMRAIDGV 118 Query: 126 LVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESV 185 ++VVD +EGV QTETV+RQAL E +KPV+ INKVDR + EL+ Sbjct: 119 IIVVDAVEGVMPQTETVVRQALREYVKPVLFINKVDRLIRELK----------------- 161 Query: 186 NVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLW 245 T +Q R++K +D +++ R Sbjct: 162 ----------------------------------LTPQQMMERFSKII-MDVNRLIQRYA 186 Query: 246 GDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEI 305 + + KKW K D +N + P + N E +++ Sbjct: 187 PEEY----KKKWMVKVEDGSVAFGSAYYNWALSVPFMKRTGVKFN----------EIIDL 232 Query: 306 VLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDAN 365 LKGD + L KA L VV +L+M+V HLPSP+ AQ YR L+EG Sbjct: 233 TLKGDNRTLRQKAPLHVV----------VLDMVVRHLPSPIEAQKYRIPHLWEGDISSDI 282 Query: 366 CIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDD 425 A+ NCDPK +++ V+K++ G A GRV++GTVKSGQ+V Y+ K Sbjct: 283 GQAMLNCDPKGKMVMVVTKIIIDKHAGEV-ATGRVWSGTVKSGQEV------YLINTKRK 335 Query: 426 LFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSV 485 IQ+V + MG ++ PAGNI+ + G+ + G E + + + Sbjct: 336 ---ARIQQVGIYMGPERINMEAVPAGNIVAVTGLRDAM--AGETVAEEQIEPFEALHYVS 390 Query: 486 SPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQD 544 PVV VA+E KN DLP+L+E L++L+K DP + + E+G+H+++G GELHLE+ L Sbjct: 391 EPVVTVAIEAKNVKDLPRLIEALRQLAKEDPTLHVKIDEETGQHLLSGMGELHLEVKLYK 450 Query: 545 LEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENG 604 L+ D G+ +++S P+V YRE++ ++SS KSPN+HNR Y+ EP+ +E+ AI+ G Sbjct: 451 LKKDW-GIDIEVSEPIVVYRESI-TKSSPMVEGKSPNRHNRFYIVVEPMPDEIYNAIKEG 508 Query: 605 II------NPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHE 658 II NP++ K A + G D AR I D N+ ID TK VQYL+E Sbjct: 509 IIPEGRVKNPKEVAKKLAEL-----GMDYEIARGIV----DIYNGNMFIDNTKGVQYLNE 559 Query: 659 IKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFL 718 + D ++ F A EGP+ E + V V +LD +H D +HRG QI P +R A + + Sbjct: 560 VMDLLIDGFHQAMDEGPLAREPVMKVIVRLLDAQVHEDNVHRGPAQIYPAIRTAIHCAMM 619 Query: 719 LADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESF 778 ++P + EP V I P + +G + + ++RGQ+V +Q + T+ A PV E F Sbjct: 620 KSNPVLYEPYQKVIINIPYEYMGAVSREITQRRGQLVDMKQE--GEVMTIIAEAPVAEMF 677 Query: 779 GFTGELRQATGGQAFPQMVFDHWSTLGSD 807 GF G +R AT G+A + + ++ Sbjct: 678 GFAGSIRSATSGRALWSTEHAGFKRVPNE 706 >6N0I-A nrPDB Length = 706 Score = 662 bits (1707), Expect = 0.0, Method: Composition-based stats. Identities = 202/824 (24%), Positives = 327/824 (39%), Gaps = 145/824 (17%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ ++AHVD GK+T T+ ++ G+ K GE A D EQERGITI Sbjct: 10 IELYRNIGIVAHVDAGKTTTTERILFYTGV--NHKMGEVHDGAATMDWMAQEQERGITIT 67 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 S A + + + S + + N+ID+PGHVDF+ EV +LRV DGA+VV Sbjct: 68 SAATTAFWQGSTKQFAH--------KYRFNIIDTPGHVDFTIEVERSLRVLDGAVVVFSG 119 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 +GV Q+ETV RQA + + INK+DR + F R V+ + Sbjct: 120 ADGVEPQSETVWRQANKYHVPRLAYINKMDRQGAD-----------FLRVVKQI------ 162 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 D+ LG V P + + G +D KM W D+ Sbjct: 163 --DQRLGHHPV-PIQLAIGSEENFMGQ----------------IDLVKMKAIYWNDA--- 200 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 + + ++ AE K L + +++ + L+ E+ ++ + Sbjct: 201 DQGTSYREEEIPAELKALADEWRAHMIEAAAEAND-------ELTMKFLDGEELSIEEIK 253 Query: 312 KDLEGKALLKVVMRKFLP------AADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDAN 365 L + + ++ L +L+ ++ +LP+P A R DD Sbjct: 254 AGLRQRTIANEIVPTILGSSFKNKGVPLMLDAVIDYLPAPSEIPAIRGTD-----PDDEE 308 Query: 366 CIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDD 425 ++ D K K+ G F RV++G + SG V N V GKK+ Sbjct: 309 KHLERHADDKEPFSALAFKIATDPFVGTL-TFARVYSGVLSSGNAVL----NSVKGKKE- 362 Query: 426 LFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSV 485 I R+V M I D AG+I L+G+ + TL + ++ M F Sbjct: 363 ----RIGRMVQMHANQRAEIKDVCAGDIAALIGMKD-VTTGDTLCDMDKPIILERMDFP- 416 Query: 486 SPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQD 544 PV+ VAVE K D K+ L +L++ DP E+G+ I++G GELHL+I + Sbjct: 417 DPVISVAVEPKTKADQEKMGIALGKLAQEDPSFRVRTDEETGQTIISGMGELHLDIIVDR 476 Query: 545 LEHDHAGVPLKISPPVVAYRE----TVESESSQTALSKSPNKHNRIYLKAEPIDEE-VSL 599 + + V I P VAYRE T E E S ++ +++ P DE L Sbjct: 477 MRREF-NVEANIGKPQVAYREKIRNTCEIEGRFVRQSGGRGQYGHCWIRFAPGDEGKEGL 535 Query: 600 AIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEI 659 N I+ +Y+ I Sbjct: 536 EFINEIVG-----------------------------------------GVVPREYIPAI 554 Query: 660 KDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLL 719 + + + K G + G + +++ + D + H + +I +M AT Sbjct: 555 QKGI----EEQMKNGVLAGYPLINLKAAVFDGSYHDVDSNEMAYKIAASM--ATKQLSQK 608 Query: 720 ADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFG 779 + EPV VE+ PE+ G I L+++RG + ++ P + ++A +P+ E FG Sbjct: 609 GGAVLLEPVMKVEVVTPEEYQGDILGDLSRRRGMIQDGDETPAGKV--IRAEVPLGEMFG 666 Query: 780 FTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAAR 823 + +R T G+A M F ++ S A IV +R Sbjct: 667 YATSMRSMTQGRASFSMEFTRYAEAP------ASIADGIVKKSR 704 >4FN5-A nrPDB Length = 709 Score = 658 bits (1698), Expect = 0.0, Method: Composition-based stats. Identities = 205/822 (24%), Positives = 336/822 (40%), Gaps = 142/822 (17%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ + AHVD GK+T T+ ++ G+ K GE A TD EQERGITI Sbjct: 10 INRYRNIGICAHVDAGKTTTTERVLFYTGV--NHKLGEVHDGAATTDWMVQEQERGITIT 67 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 S A++ + + S +++ +N+ID+PGHVDF+ EV +LRV DGA+VV Sbjct: 68 SAAVTTFWKGSRGQY---------DNYRVNVIDTPGHVDFTIEVERSLRVLDGAVVVFCG 118 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 GV Q+ETV RQA + +V +NK+DR F R VE + Sbjct: 119 TSGVEPQSETVWRQANKYGVPRIVYVNKMDRQG-----------ANFLRVVEQIK----- 162 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 + LG V P + + G VD KM W D + Sbjct: 163 ---KRLGHTPV-PVQLAIGAEENFVGQ----------------VDLIKMKAIYWND---D 199 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 K + ++ AE K L + +++ +MN LE+ E+ E Sbjct: 200 DKGMTYREEEIPAELKDLAEEWRSSMVEAAAEANEELMN-------KYLEEGEL----SE 248 Query: 312 KDLEGKALLKVVMRKFLPAADA----------LLEMIVLHLPSPVTAQAYRAEQLYEGPA 361 +++ L+ + + +PA +L+ ++ +LP+P A + Sbjct: 249 AEIKEGLRLRTLACEIVPAVCGSSFKNKGVPLVLDAVIDYLPAPTEIPAIKGVS-----P 303 Query: 362 DDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPG 421 DD ++ D K+ G F RV++G + SG V N V G Sbjct: 304 DDETVEDERHADDNEPFSSLAFKIATDPFVGTL-TFARVYSGVLSSGDSVL----NSVKG 358 Query: 422 KKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVM 481 KK+ + R+V M E I + AG+I L+G+ + TL + E ++ M Sbjct: 359 KKE-----RVGRMVQMHANQREEIKEVRAGDIAALIGMKD-VTTGDTLCSIEKPIILERM 412 Query: 482 KFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEI 540 F PV+ VAVE K D K+ L +L++ DP ESG+ I++G GELHL+I Sbjct: 413 DFP-EPVISVAVEPKTKADQEKMGIALGKLAQEDPSFRVKTDEESGQTIISGMGELHLDI 471 Query: 541 CLQDLEHDHAGVPLKISPPVVAYRETV-----ESESSQTALSKSPNKHNRIYLKAEPIDE 595 + ++ + GV I P VAYRET+ E E S + +++ D Sbjct: 472 IVDRMKREF-GVEANIGKPQVAYRETITKDNVEIEGKFVRQSGGRGQFGHCWIRFSAADV 530 Query: 596 EVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQY 655 + I G++ N V+ +Y Sbjct: 531 DEKGNITEGLV-----------------------------------FENEVVGGVVPKEY 555 Query: 656 LHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYA 715 + I+ + + K G + G + ++ + D + H + +I +M AT Sbjct: 556 IPAIQKGI----EEQMKNGVVAGYPLIGLKATVFDGSYHDVDSNEMAFKIAASM--ATKQ 609 Query: 716 GFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVN 775 K+ EP+ VE+ PE +G + LN++RG + E + ++A +P+ Sbjct: 610 LAQKGGGKVLEPIMKVEVVTPEDYMGDVMGDLNRRRGLIQGMEDTVSGKV--IRAEVPLG 667 Query: 776 ESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGE 817 E FG+ ++R + G+A M F ++ S+ ++ K Sbjct: 668 EMFGYATDVRSMSQGRASYSMEFSKYAEAPSNIVEALVKKQG 709 >6NOT-A nrPDB Length = 707 Score = 637 bits (1643), Expect = 0.0, Method: Composition-based stats. Identities = 201/812 (24%), Positives = 339/812 (41%), Gaps = 132/812 (16%) Query: 11 SLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQER 66 S ++K+ +RN+ + AH+D GK+T T+ ++ G + K GE D + EQER Sbjct: 10 SKINKLEQIRNIGICAHIDAGKTTTTERILYYTG--KSHKIGEVHEGGATMDWMEQEQER 67 Query: 67 GITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGAL 126 GITI S A + + +IN+ID+PGHVDF+ EV +LRV DGA+ Sbjct: 68 GITITSAATTCRWQ----------------DKVINIIDTPGHVDFTIEVERSLRVLDGAV 111 Query: 127 VVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVN 186 V D + GV Q+ETV RQA + + +NK+DR + F R VE + Sbjct: 112 AVFDGVAGVEPQSETVWRQADKYNVPRMCFVNKMDRMGAD-----------FYRCVEMIK 160 Query: 187 VIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWG 246 + + + + G V+ KM +W Sbjct: 161 DRLGARS---------LIIQLPIGIEENFKGI----------------VNLIKMKAVIWK 195 Query: 247 DSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIV 306 D ++ +D A+ + + +LD + L IM + E+++I+ Sbjct: 196 DESLGA---EYFEEDIPADMQDKAAEYRARLLDMVVELDDTIMEQYLSGAEITEEQIKIL 252 Query: 307 LKGDEKDLEGKALLKVVMRKFL-PAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDAN 365 ++ + +E + + F LL+ IV LPSP+ + ++ + Sbjct: 253 IR--KGTIEARFYPILCGSAFKNKGVQPLLDAIVDFLPSPIDIGIVKGIEVSTS---EEK 307 Query: 366 CIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDD 425 I +P + L K++ G F R+++G + SG V N V K++ Sbjct: 308 DFPISIVEPFSALA---FKIMNDPFVGSL-TFIRIYSGKITSGATV----INTVKNKREK 359 Query: 426 LFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSV 485 I R++LM E I + AG+I+ L G+ TL+ + ++ M+F Sbjct: 360 -----IGRMLLMHANNREDIKEASAGDIVALAGLKDT-STGDTLSDIDKQVVLERMEFP- 412 Query: 486 SPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQD 544 PV+++AVE K+ D K+ L RL+ DP E+G+ ++ G GELHLEI + Sbjct: 413 EPVIELAVEPKSTADQEKMGLALSRLAAEDPSFRVSTDHETGQTVIKGMGELHLEIIIDR 472 Query: 545 LEHDHAGVPLKISPPVVAYRETV----ESESSQTALSKSPNKHNRIYLKAEPIDEEVSLA 600 + + V I P VAYRET+ E + + S + R+ + EP+ + + L Sbjct: 473 MRREFK-VEANIGAPQVAYRETITTACEIDYTHKKQSGGAGQFARVKIIFEPLKDVIDLK 531 Query: 601 IENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQY-LHEI 659 E D K + F G + + V+ L+ I Sbjct: 532 DE--------------------------DKNKTFVFESKIVGGAVPKEYIPGVEKGLNNI 565 Query: 660 KD-SVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFL 718 ++ V+A + + + V ++L + A R G Q Sbjct: 566 RETGVIAGYPMIDFKATLVDGAFHDVDSSVLAFEIAAKGAFREGMQ-------------- 611 Query: 719 LADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESF 778 +PK+ EP+ VE+ P++ +G I LN +RGQ+ + + R + T A++P+ E F Sbjct: 612 KGNPKLLEPIMKVEVITPDEYMGDIIGDLNSRRGQIQNMDPRGNAQVVT--AHVPLAEMF 669 Query: 779 GFTGELRQATGGQAFPQMVFDHWSTLGSDPLD 810 G+ LR + G+A M+F H+ + S D Sbjct: 670 GYVNTLRSLSQGRAQFSMIFSHYDQVPSQVAD 701 >4WQY-BZ nrPDB Length = 758 Score = 618 bits (1594), Expect = e-177, Method: Composition-based stats. Identities = 192/820 (23%), Positives = 339/820 (41%), Gaps = 133/820 (16%) Query: 5 TVDQMRSLM-DKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDT 59 ++++ ++ + + +RN+ + AH+D GK+T T+ ++ G I K GE A D Sbjct: 64 EAERLKEILENDLKRLRNIGIAAHIDAGKTTTTERILYYTGRI--HKIGEVHEGAATMDF 121 Query: 60 RKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAAL 119 + E+ERGITI + + + IN+ID+PGHVDF+ EV ++ Sbjct: 122 MEQERERGITITAAVTTCFW----------------KDHRINIIDTPGHVDFTIEVERSM 165 Query: 120 RVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFA 179 RV DGA+VV D+ +GV Q+ETV RQA ++ + NK+D+ +L + + + Sbjct: 166 RVLDGAIVVFDSSQGVEPQSETVWRQAEKYKVPRIAFANKMDKTGADLWLVIRTMQERLG 225 Query: 180 RTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAK 239 + + + G +R A Y G D + Sbjct: 226 A--------------------RPVVMQLPIGREDTFSGIIDVLRMKAYTYGNDLGTDIRE 265 Query: 240 MMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVL 299 + + + + + +++ K + E ++ + +K I + Sbjct: 266 IP---IPEEYLD-QAREYHEKLVEVAADFDENIMLKYLEGEEPTEEELVAAIRKGTIDL- 320 Query: 300 LEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEG 359 K+ V G +G LL L+ +V +LPSP+ + G Sbjct: 321 --KITPVFLGSALKNKGVQLL--------------LDAVVDYLPSPLDIPPIK------G 358 Query: 360 PADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYV 419 + + I + DP L K++ GR F RV++GT+ SG V N Sbjct: 359 TTPEGEVVEI-HPDPNGPLAALAFKIMADPYVGRL-TFIRVYSGTLTSGSYVY----NTT 412 Query: 420 PGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAH--N 477 G+K+ + R++ M E +++ AG++ +VG+ + + TG E A Sbjct: 413 KGRKE-----RVARLLRMHANHREEVEELKAGDLGAVVGLKETI--TGDTLVGEDAPRVI 465 Query: 478 MKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMS-ESGEHIVAGTGEL 536 ++ ++ PV+ VA+E K D KL + L RL++ DP E+G+ I++G GEL Sbjct: 466 LESIEVP-EPVIDVAIEPKTKADQEKLSQALARLAEEDPTFRVSTHPETGQTIISGMGEL 524 Query: 537 HLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEE 596 HLEI + L+ + V + P VAYRET+ +P+D E Sbjct: 525 HLEIIVDRLKREFK-VDANVGKPQVAYRETI----------------------TKPVDVE 561 Query: 597 VSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYL 656 + G K + + G++ N ++ +Y+ Sbjct: 562 GKFIRQTGGRGQYGHVKIKVEPLPRGSGFEFV---------------NAIVGGVIPKEYI 606 Query: 657 HEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAG 716 ++ + A Q GP+ G + ++V + D + H +I +M A Sbjct: 607 PAVQKGIEEAMQ----SGPLIGFPVVDIKVTLYDGSYHEVDSSEMAFKIAGSM--AIKEA 660 Query: 717 FLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNE 776 DP I EP+ VE+ PE+ +G + LN +RGQ++ E R + ++A++P+ E Sbjct: 661 VQKGDPVILEPIMRVEVTTPEEYMGDVIGDLNARRGQILGMEPRGNAQV--IRAFVPLAE 718 Query: 777 SFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAG 816 FG+ +LR T G+ M FDH+ + + K Sbjct: 719 MFGYATDLRSKTQGRGSFVMFFDHYQEVPKQVQEKLIKGQ 758 >4V7D-BZ nrPDB Length = 711 Score = 617 bits (1591), Expect = e-177, Method: Composition-based stats. Identities = 193/810 (23%), Positives = 321/810 (39%), Gaps = 121/810 (14%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ + AH+D GK+T T+ ++ G+ K GE A D + EQERGITI Sbjct: 6 IARYRNIGISAHIDAGKTTTTERILFYTGV--NHKIGEVHDGAATMDWMEQEQERGITIT 63 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 S A + + + IN+ID+PGHVDF+ EV ++RV DGA++V Sbjct: 64 SAATTAFWSGMAKQY---------EPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCA 114 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 + GV Q+ETV RQA ++ + +NK+DR + F + V + + Sbjct: 115 VGGVQPQSETVWRQANKYKVPRIAFVNKMDR-----------MGANFLKVVNQIKTRLGA 163 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 P + + G VD KM W D+ Sbjct: 164 NP---------VPLQLAIGAEEHFTGV----------------VDLVKMKAINWNDA--- 195 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 + + +D A+ L ++ +++ +M + +++ L+ + Sbjct: 196 DQGVTFEYEDIPADMVELANEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALR--Q 253 Query: 312 KDLEGKALLKVVMRKFL-PAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAI- 369 + L + +L F A+L+ ++ +LPSPV A G DD Sbjct: 254 RVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAIN------GILDDGKDTPAE 307 Query: 370 KNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIK 429 ++ K+ G F RV++G V SG V N V ++ Sbjct: 308 RHASDDEPFSALAFKIATDPFVGNL-TFFRVYSGVVNSGDTVL----NSVKAARE----- 357 Query: 430 AIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVV 489 R+V M E I + AG+I +G+ + TL + ++ M+F PV+ Sbjct: 358 RFGRIVQMHANKREEIKEVRAGDIAAAIGLKD-VTTGDTLCDPDAPIILERMEFP-EPVI 415 Query: 490 QVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQDLEHD 548 +AVE K D K+ L RL+K DP + ES + I+AG GELHL+I + ++ + Sbjct: 416 SIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKRE 475 Query: 549 HAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINP 608 V + P VAYRET+ + + D E A ++G Sbjct: 476 F-NVEANVGKPQVAYRETIRQKVT---------------------DVEGKHAKQSGGRGQ 513 Query: 609 RDDFKARARIMADDYGWDVTDARKIWCFGPDGN-GPNLVIDQTKAVQYLHEIKDSVVAAF 667 YG V D ++ P N I+ K E +V Sbjct: 514 --------------YGHVVID---MYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGI 556 Query: 668 QWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQEP 727 Q K GP+ G + + + + + H ++ ++ A GF A P + EP Sbjct: 557 QEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASI--AFKEGFKKAKPVLLEP 614 Query: 728 VFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQA 787 + VE++ PE+ G + L+++RG + +E + A +P++E FG+ +LR Sbjct: 615 IMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTG--VKIHAEVPLSEMFGYATQLRSL 672 Query: 788 TGGQAFPQMVFDHWSTLGSDPLDPTSKAGE 817 T G+A M F + S+ +A Sbjct: 673 TKGRASYTMEFLKYDEAPSNVAQAVIEARG 702 >3ZZ0-A nrPDB Length = 693 Score = 614 bits (1584), Expect = e-176, Method: Composition-based stats. Identities = 182/817 (22%), Positives = 319/817 (39%), Gaps = 141/817 (17%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ +IAH+D GK+T T+ ++ G I K GE A D + EQ+RG Sbjct: 7 LEKTRNIGIIAHIDAGKTTTTERILYYTGRI--HKIGETHEGASQMDWMEQEQDRG---- 60 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 + +N+ID+PGHVDF+ EV +LRV DGA+ V+D Sbjct: 61 ------------ITITSAATTAAWEGHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDA 108 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 GV QTETV RQA + +V +NK+D+ + S L+ Sbjct: 109 QSGVEPQTETVWRQATTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQAN---------- 158 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 P + + + +Y G + ++ Sbjct: 159 ----------AAPIQLPIGAEDEFEAIIDLVEMKCFKYTNDLGTEIEEIEIP----EDHL 204 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 + ++ +A + + ++ D + ++ V + VL G Sbjct: 205 DRAEEARASLIEAVAETSDELMEKYLGDEEISVSELKEAIRQATTNV---EFYPVLCGTA 261 Query: 312 KDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKN 371 +G L +L+ ++ +LPSP+ + P ++ I Sbjct: 262 FKNKGVQL--------------MLDAVIDYLPSPLDVKPIIG-HRASNPEEEV----IAK 302 Query: 372 CDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAI 431 D A+ K++ G+ F RV++GT+ SG V+ N GK++ + Sbjct: 303 ADDSAEFAALAFKVMTDPYVGKL-TFFRVYSGTMTSGSYVK----NSTKGKRE-----RV 352 Query: 432 QRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQV 491 R++ M + ID +G+I VG+ TL + ++ M+F PV+ + Sbjct: 353 GRLLQMHANSRQEIDTVYSGDIAAAVGLKDT-GTGDTLCGEKNDIILESMEFP-EPVIHL 410 Query: 492 AVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLEICLQDLEHDHA 550 +VE K+ D K+ + L +L + DP + E+G+ I+ G GELHL+I + ++ + Sbjct: 411 SVEPKSKADQDKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEF- 469 Query: 551 GVPLKISPPVVAYRETVESESS-QTALSKSPN---KHNRIYLKAEPIDEEVSLAIENGII 606 V + P+V+YRET +S + Q S+ ++ ++++ P + EN I+ Sbjct: 470 NVECNVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEFENAIV 529 Query: 607 NPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAA 666 +Y+ SV A Sbjct: 530 G-----------------------------------------GVVPREYIP----SVEAG 544 Query: 667 FQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQE 726 + A + G + G + V+ + D + H +I ++ A DP I E Sbjct: 545 LKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASL--ALKEAAKKCDPVILE 602 Query: 727 PVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQ 786 P+ V I+ PE+ +G I + +RG+V E R + V AY+P++E FG+ LR Sbjct: 603 PMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQV--VNAYVPLSEMFGYATSLRS 660 Query: 787 ATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAAR 823 T G+ M FDH++ + S A +I+ + Sbjct: 661 NTQGRGTYTMYFDHYAEVP------KSIAEDIIKKNK 691 >1WDT-A nrPDB Length = 665 Score = 447 bits (1150), Expect = e-126, Method: Composition-based stats. Identities = 174/810 (21%), Positives = 301/810 (37%), Gaps = 191/810 (23%) Query: 19 VRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLY 78 +R ++++ H GK+TLT++L+ + G R+ E G T +T + Sbjct: 9 IRTVALVGHAGSGKTTLTEALLYKTG------------AKERRGRVEEGTT--TTDYTPE 54 Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQ 138 +++ V+ + L+D+PG+ DF E+ AL D ALV V GV V Sbjct: 55 AKLHRTTVRTGVAPLLFRGHRVFLLDAPGYGDFVGEIRGALEAADAALVAVSAEAGVQVG 114 Query: 139 TETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLG 198 TE A + +VV+ K+D+ D Y ++ I+ Sbjct: 115 TERAWTVAERLGLPRMVVVTKLDKGG--------DYYALLEDLRSTLGPILPI------- 159 Query: 199 DVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWT 258 D+ +Y V HG A+ RY Sbjct: 160 DLPLYEGGKWVGLIDVFHGKAY-------RYE---------------------------N 185 Query: 259 NKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEK----LEIVLKGDEKDL 314 ++ +AE P ER + F+++ + ++E LE L+G+E Sbjct: 186 GEEREAEVPPEER--------------ERVQRFRQEVLEAIVETDEGLLEKYLEGEEVTG 231 Query: 315 EG--KALLKVVMRKFLP-----------AADALLEMIVLHLPSPVTAQAYRAEQLYEGPA 361 E KA + V R L LLE+I+ LPSP E+ +GP Sbjct: 232 EALEKAFHEAVRRGLLYPVALASGEREIGVLPLLELILEALPSPT-------ERFGDGPP 284 Query: 362 DDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPG 421 A ++ DP + Y+ R Y GR+ G + +++ P+ Sbjct: 285 L-AKVFKVQ-VDPFMGQVAYL----------RLYR-GRLKPGDSLQSEAGQVRLPH---- 327 Query: 422 KKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVM 481 + + MG+ + +++ AG ++G V + L + L E + +V Sbjct: 328 ------------LYVPMGKDLLEVEEAEAGFVLG-VPKAEGLHRGMVLWQGEKPESEEVP 374 Query: 482 KFSV-SPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCV-LTYMSESGEHIVAGTGELHLE 539 + P V VA+ K D +L E L++L + DP + L E+GE ++ G GELHL Sbjct: 375 FARLPDPNVPVALHPKGRTDEARLGEALRKLLEEDPSLKLERQEETGELLLWGHGELHLA 434 Query: 540 ICLQDLEHDHAGVPLKISPPVVAYRETVES-ESSQTALSKSPNKHNR---IYLKAEPIDE 595 + L+ D+ GV ++ S P V YRET++ Q K H + ++L+ EP E Sbjct: 435 TAKERLQ-DY-GVEVEFSVPKVPYRETIKKVAEGQGKYKKQTGGHGQYGDVWLRLEPASE 492 Query: 596 EVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQY 655 G + P +A + + Sbjct: 493 YGFEWRITGGVIPSKYQEAIEEGIKE---------------------------------- 518 Query: 656 LHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYA 715 A K+G + G + + + + + H QI ++ A Sbjct: 519 --------------AAKKGVLAGFPVMGFKAIVYNGSYHEVDSSDLAFQIAASL--AFKK 562 Query: 716 GFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVN 775 A P + EP++ +++ P++ VG + S L +RG+++ EQ L V A +P+ Sbjct: 563 VMAEAHPVLLEPIYRLKVLAPQERVGDVLSDLQARRGRILGMEQE--GALSVVHAEVPLA 620 Query: 776 ESFGFTGELRQATGGQAFPQMVFDHWSTLG 805 E + L TGG + F H++ + Sbjct: 621 EVLEYYKALPGLTGGAGAYTLEFSHYAEVP 650 >6BK7-A nrPDB Length = 407 Score = 343 bits (878), Expect = 3e-94, Method: Composition-based stats. Identities = 117/473 (24%), Positives = 189/473 (39%), Gaps = 80/473 (16%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ ++AHVD GK+T T+ ++ G I K GE A D + EQERGITI Sbjct: 10 LEKTRNIGIMAHVDAGKTTTTERILYYTGKI--HKIGETHEGASQMDWMEQEQERGITIT 67 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 S A + + +N+ID+PGHVDF+ EV +LRV DGA+ V+D+ Sbjct: 68 SAATTAQW----------------KGYRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDS 111 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 GV QTETV RQA ++ +V NK+D+ + S E L+ + + + Sbjct: 112 QSGVEPQTETVWRQATEYKVPRIVFCNKMDKIGADFFYSVESLHDRLQANAHPIQIPIGA 171 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 D G I+ A Y G D + + + + Sbjct: 172 EED--------------------FTGIIDLIKMKAEIYTNDLGTD---IQETDIPEDYLE 208 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 K ++W K +A + E ++ + ++ I V + VL G Sbjct: 209 -KAQEWREKLVEAVAETDEDLMMKYLEGEEITEEELVAGIRQATINV---EFFPVLAGSA 264 Query: 312 KDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKN 371 +G L +L+ ++ +LPSP+ A + D+ Sbjct: 265 FKNKGVQL--------------MLDAVLDYLPSPLDIDAIKGIDTKT---DEETTRP--- 304 Query: 372 CDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAI 431 D +A K++ GR F RV++G ++SG V N GKK+ I Sbjct: 305 ADDEAPFASLAFKVMTDPFVGRL-TFFRVYSGVLESGSYVL----NASKGKKE-----RI 354 Query: 432 QRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFS 484 R++ M + ID +G+I VG+ TL + ++ ++F Sbjct: 355 GRILQMHANTRQEIDKVYSGDIAAAVGLKDT-TTGDTLCALDAPVILESIEFP 406 >5TY0-A nrPDB Length = 422 Score = 339 bits (870), Expect = 2e-93, Method: Composition-based stats. Identities = 125/486 (25%), Positives = 192/486 (39%), Gaps = 76/486 (15%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ + AHVD GK+T T+ ++ G+ + K GE A D EQERGITI Sbjct: 8 LKLYRNIGIAAHVDAGKTTTTERVLYYTGM--SHKIGEVHDGAATMDWMVQEQERGITIT 65 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 S A + Y D+ S IN+ID+PGHVDF EV +LRV DGA+VV D+ Sbjct: 66 SAATTCYWSGMDKQ---------FESHRINIIDTPGHVDFMIEVERSLRVLDGAVVVFDS 116 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 + GV Q+ETV RQA + +V +NK+DR + F R V + Sbjct: 117 VAGVEPQSETVWRQANKYGVPRIVFVNKMDR-----------MGANFLRVVSQIK----- 160 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 + LG V + + G +D KM W + Sbjct: 161 ---QRLGSTPVV-LQLPIGAEEEFKGV----------------IDLIKMKAIHWDEE--- 197 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 K + D A+ K + I++ +M + +++ L+ Sbjct: 198 NKGMTFKYVDIPADLKSTCEEYRAHIIEAAAEYSEELMEKYLEGEEFTEAEIKKALRH-- 255 Query: 312 KDLEGKALLKVVMRKFL-PAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIK 370 + K + F A+L+ ++ +LPSP + D+ + + Sbjct: 256 LTITNKVVPVFCGSAFKNKGVQAVLDGVIEYLPSPTDIPDIQG-------VDEHGDVIHR 308 Query: 371 NCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKA 430 K+ G + R ++G +KSG V N V GKK+ Sbjct: 309 KTSYDEPFSALAFKIATDPFVGTL-TYFRAYSGILKSGDTVY----NSVKGKKE-----R 358 Query: 431 IQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQ 490 I R++ M E I + AG+I VG+ + TL + ++ M F PV+ Sbjct: 359 IGRLLQMHANSREEIKEVRAGDIAAAVGLK-TVTTGDTLCDQDKVVILERMDFP-DPVIA 416 Query: 491 VAVEVK 496 VAVE K Sbjct: 417 VAVEPK 422 >2MZW-A nrPDB Length = 301 Score = 331 bits (847), Expect = 1e-90, Method: Composition-based stats. Identities = 83/348 (23%), Positives = 146/348 (41%), Gaps = 62/348 (17%) Query: 481 MKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYM-SESGEHIVAGTGELHLE 539 M+F PV+ ++VE K+ D K+ + L +L + DP + E+G+ I+ G GELHL+ Sbjct: 1 MEFP-EPVIHLSVEPKSKADQDKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLD 59 Query: 540 ICLQDLEHDHAGVPLKISPPVVAYRETVESESS-QTALSKSPN---KHNRIYLKAEPIDE 595 I + ++ + V + P+V+YRET +S + Q S+ ++ ++++ P + Sbjct: 60 ILVDRMKKEF-NVECNVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNET 118 Query: 596 EVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQY 655 EN I+ +Y Sbjct: 119 GAGFEFENAIVG-----------------------------------------GVVPREY 137 Query: 656 LHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYA 715 + SV A + A + G + G + V+ + D + H +I ++ A Sbjct: 138 IP----SVEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASL--ALKE 191 Query: 716 GFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVN 775 DP I EP+ V I+ PE+ +G I + +RG+V E R + V AY+P++ Sbjct: 192 AAKKCDPVILEPMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQV--VNAYVPLS 249 Query: 776 ESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAAR 823 E FG+ LR T G+ M FDH++ + S A +I+ + Sbjct: 250 EMFGYATSLRSNTQGRGTYTMYFDHYAEVP------KSIAEDIIKKNK 291 >5H7K-A nrPDB Length = 397 Score = 326 bits (835), Expect = 2e-89, Method: Composition-based stats. Identities = 145/482 (30%), Positives = 230/482 (47%), Gaps = 102/482 (21%) Query: 6 VDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQE 65 + +++ LM + +RN+ + AH+DHGK+TL+D+L+ AG+IS AG+ D + EQ Sbjct: 11 IAKIKELMLQPERIRNIGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQLVLDFDEQEQA 70 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RGITI + +S+ +G +LINLID+PGHVDF +VT A+R DG Sbjct: 71 RGITINAANVSMV------------HNYEGKDYLINLIDTPGHVDFGGDVTRAMRAIDGV 118 Query: 126 LVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESV 185 ++VVD +EGV QTETV+RQAL E +KPV+ INKVDR + EL+++ + + + F++ + V Sbjct: 119 IIVVDAVEGVMPQTETVVRQALREYVKPVLFINKVDRLIRELKLTPQQMMERFSKIIMDV 178 Query: 186 NVIVSTYA-DEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRL 244 N ++ YA +E V G+VAFGS + WA ++ + K+ GV +++D Sbjct: 179 NRLIQRYAPEEYKKKWMVKVEDGSVAFGSAYYNWALSV-----PFMKRTGVKFNEIIDL- 232 Query: 245 WGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLE 304 T K N+ + ++ +LD + R + + +K IP L E Sbjct: 233 ---------TLKGDNRTLRQKAP-----LHVVVLDMVVRHLPSPIEAQKYRIPHLWE--- 275 Query: 305 IVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDA 364 GD G+A+L Sbjct: 276 ----GDISSDIGQAML-------------------------------------------- 287 Query: 365 NCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKD 424 NCDPK +++ V+K++ G A GRV++GTVKSGQ+V Y+ K Sbjct: 288 ------NCDPKGKMVMVVTKIIIDKHAGEV-ATGRVWSGTVKSGQEV------YLINTKR 334 Query: 425 DLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFS 484 IQ+V + MG ++ PAGNI+ + G+ + G E + + + Sbjct: 335 K---ARIQQVGIYMGPERINMEAVPAGNIVAVTGLRDAM--AGETVAEEQIEPFEALHYV 389 Query: 485 VS 486 + Sbjct: 390 LE 391 >5VH6-A nrPDB Length = 409 Score = 324 bits (831), Expect = 7e-89, Method: Composition-based stats. Identities = 109/478 (22%), Positives = 187/478 (39%), Gaps = 83/478 (17%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ ++AH+D GK+T T+ ++ G I K GE A D + EQERGITI Sbjct: 10 LEKTRNIGIMAHIDAGKTTTTERILFYTGRI--HKIGETHEGASQMDWMEQEQERGITIT 67 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 S A + + +N+ID+PGHVDF+ EV +LRV DGA+ V+D Sbjct: 68 SAATTAQW----------------KGYRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDA 111 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 GV QTETV RQA + +V +NK+D+ + S L ++ + + Sbjct: 112 QSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAHAIQLPI-- 169 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 G + A Y G Sbjct: 170 ------------------GAEDNFEGIIDLVENVAYFYEDDLGT---------------- 195 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 + K+ E K +++ + L +M+ + + +++L+ ++ + Sbjct: 196 ----RSDAKEIPEEYKEQAEELRNSLIEAVCELDEELMDKYLEGEEITIDELKAGIR--K 249 Query: 312 KDLEGKALLKVVMRKFL-PAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIK 370 L + +V F +L+ ++ +LP+P A + + D N + Sbjct: 250 GTLNVEFYPVLVGSAFKNKGVQLVLDAVLDYLPAPTDVAAIKGTR------PDTNEEIER 303 Query: 371 NCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKA 430 + + K++ G+ F RV++GT+ SG V+ N GK++ Sbjct: 304 HSSDEEPFSALAFKVMTDPYVGKL-TFFRVYSGTLDSGSYVK----NSTKGKRE-----R 353 Query: 431 IQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPV 488 + R++ M E I AG+I VG+ TL + ++ M+F PV Sbjct: 354 VGRILQMHANSREEISTVYAGDIAAAVGLKDT-TTGDTLCDEKDLVILESMEFP-EPV 409 >6B8D-A nrPDB Length = 408 Score = 322 bits (824), Expect = 5e-88, Method: Composition-based stats. Identities = 106/469 (22%), Positives = 179/469 (38%), Gaps = 75/469 (15%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ + AH+D GK+T T+ ++ G+ + K GE A D + EQERGITI Sbjct: 10 IERYRNIGISAHIDAGKTTTTERILFYTGV--SHKIGEVHDGAATMDWMEQEQERGITIT 67 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 S A + + + IN+ID+PGHVDF+ EV ++RV DGA++V Sbjct: 68 SAATTAFWSGMSQQ---------FPQHRINVIDTPGHVDFTVEVERSMRVLDGAVMVYCA 118 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 + GV Q+ETV RQA + + +NK+DR F R VE + + Sbjct: 119 VGGVQPQSETVWRQANKYEVPRIAFVNKMDRTG-----------ANFLRVVEQLKTRLGA 167 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 P + V G VD KM W ++ Sbjct: 168 ---------NAIPLQLPVGAEENFTGV----------------VDLIKMKAINWNEA--- 199 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 + +T ++ A + + +++ +M + E+++ L+ Sbjct: 200 DQGMTFTYEEVPANMQADCEEWRQNLVEAAAEASEELMEKYLGGEDLTEEEIKSALRQRV 259 Query: 312 KDLEGKALLKVVMRKFL-PAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIK 370 E +L F A+L+ +V +LP+P A + + + Sbjct: 260 LANEI--ILVTCGSAFKNKGVQAMLDAVVEYLPAPTDIPAIKG-------INPDETEGER 310 Query: 371 NCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKA 430 + + K+ G F RV++G + SG V N V K++ Sbjct: 311 HASDEEPFSSLAFKIATDPFVGNL-TFFRVYSGVINSGDTVL----NSVRQKRE-----R 360 Query: 431 IQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMK 479 R+V M E I + AG+I +G+ + TL + ++ Sbjct: 361 FGRIVQMHANKREEIKEVRAGDIAAAIGLKD-VTTGDTLCAIDAPIILE 408 >5TV2-A nrPDB Length = 405 Score = 314 bits (804), Expect = 1e-85, Method: Composition-based stats. Identities = 113/469 (24%), Positives = 192/469 (40%), Gaps = 75/469 (15%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE----ARFTDTRKDEQERGITIK 71 + RN+ + AHVD GK+T T+ ++ G+ + K GE A D + EQERGITI Sbjct: 7 IERYRNIGICAHVDAGKTTTTERILFYTGL--SHKIGEVHDGAATMDWMEQEQERGITIT 64 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDT 131 S A + + + ++ +N+ID+PGHVDF+ EV +LRV DGA+VV Sbjct: 65 SAATTTFWRGMEAQFQD---------HRVNIIDTPGHVDFTIEVERSLRVLDGAVVVFCG 115 Query: 132 IEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 GV Q+ETV RQA + +V +NK+DRA + F R V+ + + Sbjct: 116 SSGVEPQSETVWRQADKYHVPRMVFVNKMDRAGAD-----------FLRVVDQIKNRLGA 164 Query: 192 YADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 P + V G +D KM W ++ Sbjct: 165 NP---------VPIQLNVGAEEDFKGV----------------IDLIKMKMINWNEA--- 196 Query: 252 PKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDE 311 + +T ++ A+ L + +++ +M+ +E + +++ L+ Sbjct: 197 DQGMTFTYEEIPADMIELAEEWRNNLVEAAAEASEELMDKYLEEGELTEAEIKQALR--A 254 Query: 312 KDLEGKALLKVVMRKFL-PAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIK 370 + L + +L F A+L+ ++ +LPSP+ A + D+ + + Sbjct: 255 RTLNNEIVLATCGSAFKNKGVQAVLDAVIEYLPSPIDVPAIKG-------IDENDNEVER 307 Query: 371 NCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKA 430 + D K+ G F RV++G V +G V N V KK+ Sbjct: 308 HADDNEPFSALAFKIATDPFVGTL-TFIRVYSGVVNTGDAVY----NSVKQKKE-----R 357 Query: 431 IQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMK 479 R+V M E I + AG+I +G+ + TL S+ ++ Sbjct: 358 FGRIVQMHANKREEIKEVRAGDIAAAIGLKD-VTTGDTLCNSDHKVILE 405 >3TR5-A nrPDB Length = 528 Score = 194 bits (492), Expect = 2e-49, Method: Composition-based stats. Identities = 109/554 (19%), Positives = 186/554 (33%), Gaps = 117/554 (21%) Query: 11 SLMDKVTNVRNMSVIAHVDHGKSTLTDSLV------QRAGIISAAKAGEARFTDTRKDEQ 64 S+ + R ++I+H D GK+TLT+ L+ Q AG I + KA +D + E+ Sbjct: 5 SVEKQTAMRRTFAIISHPDAGKTTLTEKLLLFGGAIQLAGTIKSRKAARHATSDWMELEK 64 Query: 65 ERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDG 124 +RGI++ ++ + +LINL+D+PGH DF+ + L D Sbjct: 65 QRGISVTTSVMQF----------------PYKDYLINLLDTPGHADFTEDTYRTLTAVDS 108 Query: 125 ALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVES 184 AL+V+D +GV +T ++ + INK+DR D + + Sbjct: 109 ALMVIDAAKGVEPRTIKLMEVCRLRHTPIMTFINKMDR----------DTRPSIELL-DE 157 Query: 185 VNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRL 244 + I+ + P + G G I Y Sbjct: 158 IESILR---------IHCAPVTWPIGMGKYFKGIYHLIEDAIYLYQP------------- 195 Query: 245 WGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLE--K 302 + ++ + P + E+ +E K Sbjct: 196 ------GKHERVGESERIEGINNPE---------------LDKKLGDLASELRNEIELVK 234 Query: 303 LEIVLKGDEKDLEGKALLKVVMRKFLPAADA-LLEMIVLHLPSPVTAQAYRAEQLYEGPA 361 E L+G+ LL+ V P P Q P Sbjct: 235 GASHPFEREGYLKGELTPIFFGSAINNFGVGELLDAFVKEAPPP---QGRETNSRLVKPE 291 Query: 362 DDANCIAIKNCDPKADLMLYVSKMVPTSDKG--RFYAFGRVFAGTVKSGQKVRIQGPNYV 419 ++ +V K+ D G AF R+ +G + G K +V Sbjct: 292 EE-------------KFSGFVFKIQANMDPGHRDRIAFLRIASGQYQKGMKAY-----HV 333 Query: 420 PGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMK 479 KK+ I + M E ++ G+IIG L GT+ +T + Sbjct: 334 RLKKE----IQINNALTFMAGKRENAEEAWPGDIIG-------LHNHGTIQIGDTFTQGE 382 Query: 480 VMKFSVSPVVQVA----VEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGE 535 KF+ P V +K+ L++GL +LS+ L +S E I+ G Sbjct: 383 RFKFTGIPNFASELFRLVRLKDPLKQKALLKGLTQLSEEGATQLFRPLDSNELILGAVGL 442 Query: 536 LHLEICLQDLEHDH 549 L ++ LE+++ Sbjct: 443 LQFDVVAYRLENEY 456 >4V89-AW nrPDB Length = 534 Score = 189 bits (480), Expect = 4e-48, Method: Composition-based stats. Identities = 98/562 (17%), Positives = 192/562 (34%), Gaps = 119/562 (21%) Query: 9 MRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLV------QRAGIISAAKAGEARFTDTRKD 62 + + +V R ++I+H D GK+T+T+ ++ Q AG + + + +D + Sbjct: 3 LSPYLQEVAKRRTFAIISHPDAGKTTITEKVLLFGQAIQTAGTVKGRGSNQHAKSDWMEM 62 Query: 63 EQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVT 122 E++RGI+I ++ + + L+NL+D+PGH DFS + L Sbjct: 63 EKQRGISITTSVMQF----------------PYHDCLVNLLDTPGHEDFSEDTYRTLTAV 106 Query: 123 DGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTV 182 D L+V+D +GV +T ++ + +NK+DR + + +++ Sbjct: 107 DCCLMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKLDRDIRDPMELLDEVENEL---- 162 Query: 183 ESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMD 242 + P + G G + Y G ++ Sbjct: 163 ----------------KIGCAPITWPIGCGKLFKGVYHLYKDETYLYQSGKGHTIQEVRI 206 Query: 243 RLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEK 302 K N D DA +D L ++ Sbjct: 207 V-----------KGLNNPDLDAAVG-------------------------EDLAQQLRDE 230 Query: 303 LEIVLKGDEKDLEGKALLKVVMRKFLPAADA------LLEMIVLHLPSPVTAQAYRAEQL 356 LE+V + + L + F A +L+ +V P+P+ Sbjct: 231 LELVKGASNEFDKELFLAGEITPVFFGTALGNFGVDHMLDGLVEWAPAPM---------- 280 Query: 357 YEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGP 416 P + D + + + + R AF RV +G + G K+R Sbjct: 281 ---PRQTDTRTVEASEDKFTGFVFKIQANMDPKHRDRV-AFMRVVSGKYEKGMKLRQV-- 334 Query: 417 NYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAH 476 I + M +++ G+I+G L GT+ +T Sbjct: 335 -------RTAKDVVISDALTFMAGDRSHVEEAYPGDILG-------LHNHGTIQIGDTFT 380 Query: 477 NMKVMKFSVSPVVQVA----VEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAG 532 ++MKF+ P + +K+ +L++GL +LS+ + + + IV Sbjct: 381 QGEMMKFTGIPNFAPELFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPISNNDLIVGA 440 Query: 533 TGELHLEICLQDLEHDHAGVPL 554 G L ++ + L+ ++ V Sbjct: 441 VGVLQFDVVVARLKSEY-NVEA 461 >3VQT-A nrPDB Length = 548 Score = 185 bits (470), Expect = 6e-47, Method: Composition-based stats. Identities = 105/548 (19%), Positives = 189/548 (34%), Gaps = 115/548 (20%) Query: 21 NMSVIAHVDHGKSTLTDSLV------QRAGIISAAKAGEARFTDTRKDEQERGITIKSTA 74 ++I+H D GK+TLT+ L+ Q AG + A KA +D E+ERGI++ ++ Sbjct: 33 TFAIISHPDAGKTTLTEKLLLFGGAIQMAGSVKARKAARHATSDWMAMERERGISVTTSV 92 Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 + ++NL+D+PGH DFS + L D ALVV+D +G Sbjct: 93 MQF----------------PYRDRVVNLLDTPGHQDFSEDTYRVLTAVDSALVVIDAAKG 136 Query: 135 VCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYAD 194 V QT ++ + +NK+DR L D+ Q Sbjct: 137 VEAQTRKLMDVCRMRATPVMTFVNKMDREALHPLDVMADIEQHLQ--------------- 181 Query: 195 EVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKT 254 ++ P + GS G + + ++ G + D +P+ Sbjct: 182 -----IECAPMTWPIGMGSSFKGTYDLLHKQLHLFSATHGGRIQSGIVIHGAD---DPQL 233 Query: 255 KKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDL 314 ++ + L +L+ F E LKG+ L Sbjct: 234 DEYLGDQAEQLRMDLA------LLEEAGTPFDE----------------ERYLKGE---L 268 Query: 315 EGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDP 374 + +L+M V P P A A + +P Sbjct: 269 TPVFFGSAINNF---GVREMLDMFVEFAPGPQPRPA-----------------ATRVVEP 308 Query: 375 -KADLMLYVSKMVPTSDKG--RFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAI 431 + V K+ DK AF R+ +GT G ++ ++ GK + Sbjct: 309 GEEAFTGVVFKIQANMDKAHRDRMAFLRICSGTFTRG----MRLKHHRTGK-----DVTV 359 Query: 432 QRVVLMMGRFVEPIDDCPAGNIIGL-----VGIDQFLLKTGTLTTSETAHNMKVMKFSVS 486 + M + +++ G+IIG+ + I ++ + N F Sbjct: 360 ANATIFMAQDRTGVEEAFPGDIIGIPNHGTIKIGDTFTESKEVLKFVGIPNFAPEHFRR- 418 Query: 487 PVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEICLQDLE 546 V +KN +L +GL++L++ L + ++I+ G L ++ + L Sbjct: 419 ------VRLKNPLKAKQLQKGLEQLAEEGAVQLFRPLVNNDYILGAVGVLQFDVIVARLA 472 Query: 547 HDHAGVPL 554 ++ GV Sbjct: 473 DEY-GVDA 479 >4J0Q-A nrPDB Length = 433 Score = 175 bits (442), Expect = 9e-44, Method: Composition-based stats. Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 22/196 (11%) Query: 10 RSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGIT 69 + D+ N+ I HVDHGK+TLT +L + + + E D+ +E+ RGIT Sbjct: 39 KEKFDRSLPHVNVGTIGHVDHGKTTLTAALTRVCSEVFGSAIVEFDKIDSAPEEKARGIT 98 Query: 70 IKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVV 129 I + + S + +D PGH D+ + DGA++V Sbjct: 99 INTAHVEYNSTI----------------RHYAHVDCPGHADYVKNMITGAAQMDGAILVC 142 Query: 130 DTIEGVCVQTETVLRQALGERIK-PVVVINKV----DRALLEL-QVSKEDLYQTFARTVE 183 +G QT + + + VV +NK D LLEL ++ DL T+ + Sbjct: 143 SAADGPMPQTREHILLSRQVGVPYIVVFLNKADLVDDAELLELVEMEVRDLLSTYDFPGD 202 Query: 184 SVNVIVSTYADEVLGD 199 +I+ + + G Sbjct: 203 DTPIIIGSARMALEGK 218 >4ZV4-A nrPDB Length = 405 Score = 175 bits (442), Expect = 1e-43, Method: Composition-based stats. Identities = 47/196 (23%), Positives = 78/196 (39%), Gaps = 22/196 (11%) Query: 10 RSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGIT 69 + ++ N+ I HVDHGK+TLT +L + A D +E+ RGIT Sbjct: 3 KEKFERNKPHVNVGTIGHVDHGKTTLTAALTKVCSDTWGGSARAFDQIDNAPEEKARGIT 62 Query: 70 IKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVV 129 I ++ + S + +D PGH D+ + DGA++V Sbjct: 63 INTSHVEYDSAV----------------RHYAHVDCPGHADYVKNMITGAAQMDGAILVC 106 Query: 130 DTIEGVCVQTETVLRQALGERIK-PVVVINKVDRA----LLEL-QVSKEDLYQTFARTVE 183 +G QT + + + VV +NK D LLEL ++ DL T+ + Sbjct: 107 SAADGPMPQTREHILLSRQVGVPYIVVFLNKADMVDDAELLELVEMEVRDLLNTYDFPGD 166 Query: 184 SVNVIVSTYADEVLGD 199 +I+ + + G Sbjct: 167 DTPIIIGSALMALEGK 182 >4V5G-AZ nrPDB Length = 406 Score = 174 bits (441), Expect = 1e-43, Method: Composition-based stats. Identities = 48/181 (26%), Positives = 75/181 (41%), Gaps = 23/181 (12%) Query: 15 KVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIIS-AAKAGEARFTDTRKDEQERGITIKST 73 + N+ I HVDHGK+TLT +L A + + + D +E+ RGITI + Sbjct: 8 RTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERARGITINTA 67 Query: 74 AISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIE 133 + + + +D PGH D+ + DGA++VV + Sbjct: 68 HVEYETA----------------KRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAAD 111 Query: 134 GVCVQTETVLRQALGERIK-PVVVINKVDRA----LLEL-QVSKEDLYQTFARTVESVNV 187 G QT + A + VV +NKVD LL+L ++ DL + + V V Sbjct: 112 GPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPV 171 Query: 188 I 188 I Sbjct: 172 I 172 >5W7Q-A nrPDB Length = 373 Score = 172 bits (434), Expect = 8e-43, Method: Composition-based stats. Identities = 45/191 (23%), Positives = 76/191 (39%), Gaps = 22/191 (11%) Query: 15 KVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTA 74 + N+ I HVDHGK+TLT ++ A+A D +E+ RGITI + Sbjct: 1 RTKPHVNIGTIGHVDHGKTTLTAAITTVLAKKGGAEAKAYDQIDNAPEEKARGITINTAH 60 Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 + +E + +D PGH D+ + DGA++VV +G Sbjct: 61 VEYETE----------------NRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADG 104 Query: 135 VCVQTETVLRQALGERIK-PVVVINKVDR-----ALLELQVSKEDLYQTFARTVESVNVI 188 QT + A + VV +NK D L +++ +L + + + +I Sbjct: 105 PMPQTREHILLARQVGVPYIVVFLNKCDMVDDEELLELVEMEVRELLSEYDFPGDDIPII 164 Query: 189 VSTYADEVLGD 199 + + GD Sbjct: 165 RGSALKALEGD 175 >5W75-A nrPDB Length = 392 Score = 171 bits (433), Expect = 1e-42, Method: Composition-based stats. Identities = 50/179 (27%), Positives = 74/179 (41%), Gaps = 22/179 (12%) Query: 19 VRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLY 78 N+ I HVDHGKSTLT ++ + + A+ D +E+ RGITI T + Sbjct: 4 HVNVGTIGHVDHGKSTLTAAITKYLSLKGLAQYVPYDQIDKAPEEKARGITINITHVEYE 63 Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQ 138 +E ID PGH D+ + DGA++VV +G Q Sbjct: 64 TE----------------KRHYAHIDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQ 107 Query: 139 TETVLRQALGERIK-PVVVINKVDRA----LLEL-QVSKEDLYQTFARTVESVNVIVST 191 T + A + +V INK D L+EL ++ DL + + V VI + Sbjct: 108 TREHVLLARQVGVPYMIVFINKTDMVDDPELIELVEMEVRDLLSQYEYPGDEVPVIKGS 166 >3CB4-D nrPDB Length = 599 Score = 170 bits (431), Expect = 2e-42, Method: Composition-based stats. Identities = 63/161 (39%), Positives = 98/161 (60%), Gaps = 12/161 (7%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAI 75 + N+RN S+IAH+DHGKSTL+D ++Q G +S + EA+ D+ E+ERGITIK+ ++ Sbjct: 1 MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREM-EAQVLDSMDLERERGITIKAQSV 59 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 +L + SD G ++ +N ID+PGHVDFS EV+ +L +GAL+VVD +GV Sbjct: 60 TLDYKASD-----------GETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGV 108 Query: 136 CVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 QT A+ ++ V V+NK+D + + E++ Sbjct: 109 EAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIED 149 Score = 61.9 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 48/212 (22%), Positives = 78/212 (36%), Gaps = 20/212 (9%) Query: 393 RFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGN 452 + R+ GT++ G KV++ Q + G Sbjct: 205 GVVSLIRIKNGTLRKGDKVKVMSTGQTYNADRLGIFTPKQV-------DRTELKCGEVGW 257 Query: 453 IIGLVGIDQFLLKTGTLTTSETAHNMKVMKFS-VSPVVQVAVEVKNANDLPKLVEGLKRL 511 ++ + TLT + + F V P V + +++D + L +L Sbjct: 258 LVCAIKDIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKL 317 Query: 512 SKSDPCVLTYMSESGEHIVAG-----TGELHLEICLQDLEHDHAGVPLKISPPVVAYRET 566 S +D + Y ES + G G LH+EI + LE ++ + L + P V Y Sbjct: 318 SLNDASLF-YEPESSSALGFGFRCGFLGLLHMEIIQERLEREY-DLDLITTAPTVVYE-- 373 Query: 567 VESESSQTALSKSPNKH---NRIYLKAEPIDE 595 VE+ S + SP+K N IY EPI E Sbjct: 374 VETTSREVIYVDSPSKLPAVNNIYELREPIAE 405 Score = 39.9 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 31/80 (38%), Gaps = 3/80 (3%) Query: 724 IQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNE-SFGFTG 782 ++EP+ + P+ +G + ++ +KRG + T +P+ E F Sbjct: 399 LREPIAECHMLLPQAYLGNVITLCVEKRGVQTNMVYHGNQVALTY--EIPMAEVVLDFFD 456 Query: 783 ELRQATGGQAFPQMVFDHWS 802 L+ + G A F + Sbjct: 457 RLKSTSRGYASLDYNFKRFQ 476 >3MMP-A nrPDB Length = 678 Score = 169 bits (428), Expect = 4e-42, Method: Composition-based stats. Identities = 41/196 (20%), Positives = 74/196 (37%), Gaps = 22/196 (11%) Query: 10 RSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGIT 69 + ++ N+ I HVDHGK+TLT ++ A D +E+ RGIT Sbjct: 287 KEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGIT 346 Query: 70 IKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVV 129 I ++ + D + +D PGH D+ + DGA++VV Sbjct: 347 INTSHVEY----------------DTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVV 390 Query: 130 DTIEGVCVQTETVLRQALGERIK-PVVVINKVDR-----ALLELQVSKEDLYQTFARTVE 183 +G QT + + +V +NK D L +++ +L + + Sbjct: 391 AATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGD 450 Query: 184 SVNVIVSTYADEVLGD 199 ++ + + GD Sbjct: 451 DTPIVRGSALKALEGD 466 >5W76-A nrPDB Length = 385 Score = 169 bits (427), Expect = 5e-42, Method: Composition-based stats. Identities = 46/187 (24%), Positives = 78/187 (41%), Gaps = 22/187 (11%) Query: 19 VRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLY 78 N+ I HVDHGK+TLT ++ + A+ D +E+ERGITI + + Sbjct: 4 HVNIGTIGHVDHGKTTLTAAITKVLAEKGQAEFKAYDQIDKAPEEKERGITISTAHVEYE 63 Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQ 138 +E + +D PGH D+ + DGA++VV +G Q Sbjct: 64 TE----------------NRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQ 107 Query: 139 TETVLRQALGERIK-PVVVINKVDR-----ALLELQVSKEDLYQTFARTVESVNVIVSTY 192 T + A + VV +NKVD L +++ +L ++ + + +I + Sbjct: 108 TREHILLARQVGVPYIVVFLNKVDMVDDEELLELVEMEVRELLSSYDFPGDDIPIIKGSA 167 Query: 193 ADEVLGD 199 + GD Sbjct: 168 LKALEGD 174 >4V6V-A1 nrPDB Length = 639 Score = 168 bits (426), Expect = 7e-42, Method: Composition-based stats. Identities = 52/165 (31%), Positives = 88/165 (53%), Gaps = 20/165 (12%) Query: 18 NVRNMSVIAHVDHGKSTLTDSLVQRAGIIS---AAKAGEARFTDTRKDEQERGITIKSTA 74 + N+ ++AHVD GK+TLT+SL+ +G I+ + G R TDT E++RGITI++ Sbjct: 2 KIINLGILAHVDAGKTTLTESLLYTSGAIAELGSVDEGTTR-TDTMNLERQRGITIQTAV 60 Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 S E +N+ID+PGH+DF +EV +L V DGA+++V +G Sbjct: 61 TSFQWE----------------DVKVNIIDTPGHMDFLAEVYRSLSVLDGAVLLVSAKDG 104 Query: 135 VCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFA 179 + QT + +I + INK+D+ ++L + ++ + Sbjct: 105 IQAQTRILFHALQIMKIPTIFFINKIDQEGIDLPMVYREMKAKLS 149 Score = 82.7 bits (202), Expect = 7e-16, Method: Composition-based stats. Identities = 69/456 (15%), Positives = 161/456 (35%), Gaps = 66/456 (14%) Query: 370 KNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIK 429 + +++L V K+ + + RF + R+++GT+ +RI +K+ + Sbjct: 241 STPEGQSELCGQVFKIEYSEKRRRF-VYVRIYSGTLHLRDVIRI-------SEKEKI--- 289 Query: 430 AIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVV 489 I + + + D +G+I+ L +L+ ++ +E + + P++ Sbjct: 290 KITEMYVPTNGELYSSDTACSGDIVIL---PNDVLQLNSILGNEILLPQRKFIENPLPMI 346 Query: 490 QVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESG-EHIVAGTGELHLEICLQDLEHD 548 Q + VK + L+ L +S DP + Y+ + E I++ G + +E+ LE Sbjct: 347 QTTIAVKKSEQREILLGALTEISDCDPLLKYYVDTTTHEIILSFLGNVQMEVICAILEEK 406 Query: 549 HAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINP 608 + V +I P V Y E ++ T I+++ P NP Sbjct: 407 YH-VEAEIKEPTVIYMERPLRKAEYT-----------IHIEVPP--------------NP 440 Query: 609 RDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHE-IKDSVVAAF 667 + P G + + ++ YL++ +++V+ Sbjct: 441 FWASVGLS-------------------IEPLPIGSGVQYESRVSLGYLNQSFQNAVMEGV 481 Query: 668 QWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQEP 727 + ++G ++G ++ ++ ++ +++ + A ++ EP Sbjct: 482 LYGCEQG-LYGWKVTDCKICFEYGLYYSPVSTPADFRLLSPI--VLEQALKKAGTELLEP 538 Query: 728 VFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQA 787 EI P++ + Y + +VS Q + +K +P + +L Sbjct: 539 YLHFEIYAPQEYLSRAYHDAPRYCADIVS-TQIKNDEV-ILKGEIPARCIQEYRNDLTYF 596 Query: 788 TGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAAR 823 T GQ + + + + R Sbjct: 597 TNGQGVCLTELKGYQPAIGKFICQPRRPNSRIDKVR 632 >5KCS-1w nrPDB Length = 639 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 21/202 (10%) Query: 18 NVRNMSVIAHVDHGKSTLTDSLVQRAGIIS---AAKAGEARFTDTRKDEQERGITIKSTA 74 + N+ V+AHVD GK+TLT+SL+ +G I+ + G R TD E++RGITI++ Sbjct: 2 KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTR-TDNTLLERQRGITIQTGI 60 Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 S E + +N+ID+PGH+DF +EV +L V DGA++++ +G Sbjct: 61 TSFQWENTK----------------VNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDG 104 Query: 135 VCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYAD 194 V QT + I + INK+D+ ++L +D+ + + + + V Y + Sbjct: 105 VQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEI-VIKQKVELYPN 163 Query: 195 EVLGDVQVYPARGTVAFGSGLH 216 + + TV G+ Sbjct: 164 VCVTNFTESEQWDTVIEGNDDL 185 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 68/450 (15%), Positives = 164/450 (36%), Gaps = 66/450 (14%) Query: 376 ADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVV 435 ++L V K+ T + R A+ R+++G + VR+ +K+ + + + Sbjct: 247 SELCGNVFKIEYTKKRQRL-AYIRLYSGVLHLRDSVRV-------SEKEKI---KVTEMY 295 Query: 436 LMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEV 495 + + ID +G I+ L ++FL L ++ K ++ P++Q VE Sbjct: 296 TSINGELCKIDRAYSGEIVIL--QNEFLKLNSVLGDTKLLPQRKKIENP-HPLLQTTVEP 352 Query: 496 KNANDLPKLVEGLKRLSKSDPCVLTYMSESG-EHIVAGTGELHLEICLQDLEHDHAGVPL 554 L++ L +S SDP + Y+ + E I++ G++ +E+ L+ + V + Sbjct: 353 SKPEQREMLLDALLEISDSDPLLRYYVDSTTHEIILSFLGKVQMEVISALLQEKYH-VEI 411 Query: 555 KISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKA 614 +I+ P V Y E + T I+++ P NP Sbjct: 412 EITEPTVIYMERPLKNAEYT-----------IHIEVPP--------------NPFWASIG 446 Query: 615 RARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHE-IKDSVVAAFQWATKE 673 + P G + + + ++ YL++ +++V+ ++ ++ Sbjct: 447 LS-------------------VSPLPLGSGMQYESSVSLGYLNQSFQNAVMEGIRYGCEQ 487 Query: 674 GPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQEPVFLVEI 733 G ++G + ++ ++ +++ + A ++ EP +I Sbjct: 488 G-LYGWNVTDCKICFKYGLYYSPVSTPADFRMLAPI--VLEQVLKKAGTELLEPYLSFKI 544 Query: 734 QCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAF 793 P++ + Y+ K +V + + + +P + +L T G++ Sbjct: 545 YAPQEYLSRAYNDAPKYCANIVDTQLKNNE--VILSGEIPARCIQEYRSDLTFFTNGRSV 602 Query: 794 PQMVFDHWSTLGSDPLDPTSKAGEIVLAAR 823 + +P+ + + R Sbjct: 603 CLTELKGYHVTTGEPVCQPRRPNSRIDKVR 632 >6MIJ-A nrPDB Length = 396 Score = 167 bits (421), Expect = 3e-41, Method: Composition-based stats. Identities = 46/237 (19%), Positives = 89/237 (37%), Gaps = 27/237 (11%) Query: 10 RSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGIT 69 ++ ++ N+ I HVDHGK+TLT ++ +A + D+ +E+ RGIT Sbjct: 3 KAKFERNKPHVNVGTIGHVDHGKTTLTAAIATICAKTYGGEAKDYSQIDSAPEEKARGIT 62 Query: 70 IKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVV 129 I ++ + D + +D PGH D+ + DGA++V Sbjct: 63 INTSHVEY----------------DSPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVC 106 Query: 130 DTIEGVCVQTETVLRQALGERIK-PVVVINKV-----DRALLELQVSKEDLYQTFARTVE 183 +G QT + + + +V +NK + L +++ +L T+ + Sbjct: 107 AATDGPMPQTREHILLSRQVGVPYIIVFLNKCDLVDDEELLELVEMEVRELLSTYDFPGD 166 Query: 184 SVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTI-----RQFATRYAKKFGV 235 VI + + G+ Y +A + L + + F F + Sbjct: 167 DTPVIRGSALAALNGEAGPYGEESVLALVAALDSYIPEPERAIDKAFLMPIEDVFSI 223 >5A9Z-CA nrPDB Length = 593 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 56/166 (33%), Positives = 85/166 (51%), Gaps = 16/166 (9%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAI 75 + +RN+++IAHVDHGK+TL D L+Q++G + + R D+ E+ERGITI + Sbjct: 2 IEKLRNIAIIAHVDHGKTTLVDKLLQQSGTFDSRAETQERVMDSNDLEKERGITILAKNT 61 Query: 76 SLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGV 135 + IN++D+PGH DF EV + + D L+VVD +G Sbjct: 62 ----------------AAIKWDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGP 105 Query: 136 CVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFART 181 QT V ++A +KP+VVINKVDR + ++ F Sbjct: 106 MPQTRFVTKKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNL 151 Score = 73.8 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 47/244 (19%), Positives = 88/244 (36%), Gaps = 49/244 (20%) Query: 332 DALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDK 391 L + IV H+P+P + D + +S++ S Sbjct: 184 TPLYQAIVDHVPAP-------------------------DVDLDGPFQMQISQLDYNSYV 218 Query: 392 GRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAG 451 G GR+ G VK Q+V + + + +V+ +G D AG Sbjct: 219 G-VIGIGRIKRGKVKPNQQV------TIIDSEGKTRNAKVGKVLGHLGLERIETDLAEAG 271 Query: 452 NIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLV------ 505 +I+ + L + T+ ++ + + P V + V + K Sbjct: 272 DIVAIT----ELNISDTVCDTQNVEALPALS-VDEPTVSMFFCVNTSPFCGKEGKFVTSR 326 Query: 506 EGLKRLSKS----DPCVLTYMSESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVV 561 + L RL+K + ++ V+G GELHL + ++++ + G L +S P V Sbjct: 327 QILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRRE--GFELAVSRPKV 384 Query: 562 AYRE 565 +RE Sbjct: 385 IFRE 388 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 53/142 (37%), Gaps = 6/142 (4%) Query: 696 DAIHRGGGQIIPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVV 755 + + R G ++ + + F D + QEP V + EQ G + L +++G + Sbjct: 368 ENMRREGFELAVSRPKVI---FREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLK 424 Query: 756 SEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKA 815 + + + +P GF E T G F H+ + P + + Sbjct: 425 NMNPDGKGRV-RLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDV--RPGEVGQRQ 481 Query: 816 GEIVLAARKRHGMKEEVPGWQE 837 ++++ + + + G Q+ Sbjct: 482 NGVLISNGQGKAVAFALFGLQD 503 >1MJ1-A nrPDB Length = 405 Score = 166 bits (419), Expect = 4e-41, Method: Composition-based stats. Identities = 48/181 (26%), Positives = 77/181 (42%), Gaps = 23/181 (12%) Query: 15 KVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIIS-AAKAGEARFTDTRKDEQERGITIKST 73 + N+ I HVDHGK+TLT +L A + + + D ++E+ RGITI + Sbjct: 7 RTKRHVNVGTIGHVDHGKTTLTAALTYVAAAENRNVEVKDYGDIDKAREERARGITINTA 66 Query: 74 AISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIE 133 + + + +D GH D+ + DGA++VV + Sbjct: 67 HVEYETA----------------KRHYSHVDCRGHADYIKNMITGAAQMDGAILVVSAAD 110 Query: 134 GVCVQTETVLRQALGERIK-PVVVINKV----DRALLEL-QVSKEDLYQTFARTVESVNV 187 G QT + A ++ VV +NKV DR LL+L ++ DL + + V V Sbjct: 111 GRMRQTREHILLARQVGVRYIVVFMNKVDMVDDRELLDLVEMEVRDLLNQYEFRGDEVRV 170 Query: 188 I 188 I Sbjct: 171 I 171 >5J8B-z nrPDB Length = 679 Score = 166 bits (419), Expect = 4e-41, Method: Composition-based stats. Identities = 58/180 (32%), Positives = 99/180 (55%), Gaps = 12/180 (6%) Query: 5 TVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQ 64 ++++ +++ ++ +RN S+IAHVDHGKSTL D +++ +S + E +F D+ + E+ Sbjct: 64 EAERLKEILENLSRIRNFSIIAHVDHGKSTLADRILELTHAVSDREMRE-QFLDSLELER 122 Query: 65 ERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDG 124 ERGITIK++A+ + + DG ++ +LID+PGHVDF+ EV+ AL +G Sbjct: 123 ERGITIKASAVRV-----------TYRAKDGEEYVFHLIDTPGHVDFTYEVSRALAAVEG 171 Query: 125 ALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVES 184 L+VVD +GV +T AL + VINK+D ++ + + Sbjct: 172 VLLVVDASQGVEAETLAKFYMALEHGHVIIPVINKIDLPNARPLEVALEVEEVLGLPADE 231 Score = 66.1 bits (159), Expect = 6e-11, Method: Composition-based stats. Identities = 81/417 (19%), Positives = 146/417 (35%), Gaps = 54/417 (12%) Query: 303 LEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPAD 362 LE+ L+ +E K + +LE IV +P P Sbjct: 215 LEVALEVEEVLGLPADEAIFASGKTGEGVEEILEAIVQRIPPPKG--------------- 259 Query: 363 DANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGK 422 DP+A L + V + +G + R+F G V+ G ++RI Y GK Sbjct: 260 ----------DPEAPLKALIFDSVYDAYQG-VIPYLRLFEGRVRPGDRIRI----YSTGK 304 Query: 423 KDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLK---TGTLTTSETAHNMK 479 + + +V + + + + AG + LV + + T+T ++ Sbjct: 305 E-----FTVDKVGVFTPQGLVATEALEAGEVGWLVAAIRDIHDVQVGDTITLADRPTPSP 359 Query: 480 VMKF-SVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAG-----T 533 F PVV + ++ D KL + L++L +D + T+ ES + G Sbjct: 360 YPGFRPAKPVVFAGLYPVDSGDYGKLRDALEKLKLNDAAL-TFEPESSTALGFGFRCGFL 418 Query: 534 GELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPN---KHNRIYLKA 590 G LH EI + LE + G+ L + P V Y+ V +S + +P RI Sbjct: 419 GLLHAEIVQERLEREF-GLSLIATAPSVVYK--VRLKSGEEVEVHNPADLPDPTRIEEIL 475 Query: 591 EPIDEEVSLAIENGIINPRD-DFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQ 649 EP + E + + + R R++ +Y ++ P D+ Sbjct: 476 EPYVKLTIFTPEEYVGSLMQLLQEKRGRLVNMNYLPGAQKRVELVYEAPFAEILYDFHDR 535 Query: 650 TKAVQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQII 706 K+V + D A ++ + V+ L H + + I+ Sbjct: 536 LKSVSRGYASMDYEQAGYRPGDL--VKVNVLVHGEVVDALTFIAHREKAYTMARAIV 590 Score = 54.5 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 41/101 (40%), Gaps = 4/101 (3%) Query: 724 IQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFT-VKAYLPVNE-SFGFT 781 I EP + I PE+ VG + +L +KRG++V+ PG + P E + F Sbjct: 474 ILEPYVKLTIFTPEEYVGSLMQLLQEKRGRLVNMNYLPGAQKRVELVYEAPFAEILYDFH 533 Query: 782 GELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAA 822 L+ + G A M ++ D + V+ A Sbjct: 534 DRLKSVSRGYA--SMDYEQAGYRPGDLVKVNVLVHGEVVDA 572 >1D2E-A nrPDB Length = 397 Score = 165 bits (416), Expect = 1e-40, Method: Composition-based stats. Identities = 47/179 (26%), Positives = 73/179 (40%), Gaps = 22/179 (12%) Query: 19 VRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLY 78 N+ I HVDHGK+TLT ++ + AK + D +E+ RGITI + + Sbjct: 3 HVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYS 62 Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQ 138 + D PGH D+ + DG ++VV +G Q Sbjct: 63 TAA----------------RHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQ 106 Query: 139 TETVLRQALGERIKPVVV-INKVDRA----LLEL-QVSKEDLYQTFARTVESVNVIVST 191 T L A ++ VVV +NK D ++EL ++ +L F E +IV + Sbjct: 107 TREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPIIVGS 165 >2YWH-A nrPDB Length = 600 Score = 160 bits (403), Expect = 3e-39, Method: Composition-based stats. Identities = 63/170 (37%), Positives = 98/170 (57%), Gaps = 12/170 (7%) Query: 15 KVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTA 74 + NVRN +IAHVDHGKSTL D L++ G IS + E + DT E+ERGIT+K A Sbjct: 2 EQKNVRNFCIIAHVDHGKSTLADRLLEYTGAISEREKRE-QLLDTLDVERERGITVKMQA 60 Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 + ++ + D GN++ ++LID+PGHVDFS EV+ AL +GAL+++D +G Sbjct: 61 VRMFYKAKD-----------GNTYKLHLIDTPGHVDFSYEVSRALAACEGALLLIDASQG 109 Query: 135 VCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVES 184 + QT +A+ + + + VINK+D ++ K+ + + E Sbjct: 110 IEAQTVANFWKAVEQDLVIIPVINKIDLPSADVDRVKKQIEEVLGLDPEE 159 Score = 66.9 bits (161), Expect = 4e-11, Method: Composition-based stats. Identities = 44/198 (22%), Positives = 75/198 (37%), Gaps = 16/198 (8%) Query: 373 DPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQ 432 DP+ L + +G AF R+F G VK G K+ + K+ + Sbjct: 188 DPQKPLKALIFDSYYDPYRGAV-AFVRIFDGEVKPGDKIMLMSTG-----KEYEVTEVGA 241 Query: 433 RVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKF-SVSPVVQV 491 + M D G I + + + T+T ++ V F P+V Sbjct: 242 QTPKMTKFDKLSAGDV--GYIAASIKDVRDIRIGDTITHAKNPTKEPVPGFQPAKPMVYA 299 Query: 492 AVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAG-----TGELHLEICLQDLE 546 + +L + L++ + +D + Y ES + G G LH+EI + LE Sbjct: 300 GIYPAEDTTYEELRDALEKYAIND-AAIVYEPESSPALGMGFRVGFLGLLHMEIVQERLE 358 Query: 547 HDHAGVPLKISPPVVAYR 564 ++ GV + + P V YR Sbjct: 359 REY-GVKIITTAPNVIYR 375 Score = 44.1 bits (102), Expect = 3e-04, Method: Composition-based stats. Identities = 20/83 (24%), Positives = 37/83 (44%), Gaps = 4/83 (4%) Query: 726 EPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESF-GFTGEL 784 EP LV I P++ VG I + +KRG + ++ ++ +P++E F ++ Sbjct: 405 EPFVLVTIITPKEYVGPIIQLCQEKRGIQKNMTYLDPNTVY-LEYEMPLSEIIVDFHDKI 463 Query: 785 RQATGGQAFPQMVFDHWSTLGSD 807 + + G A F + SD Sbjct: 464 KSISRGFASYDYEFIGYR--PSD 484 >5IMR-C nrPDB Length = 610 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 58/170 (34%), Positives = 92/170 (54%), Gaps = 12/170 (7%) Query: 15 KVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTA 74 ++ +RN S+IAHVDHGKSTL D +++ +S + E +F D+ + E+ERGITIK++A Sbjct: 5 DLSRIRNFSIIAHVDHGKSTLADRILELTHAVSDREMRE-QFLDSLELERERGITIKASA 63 Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 + + + DG ++ +LID+PGHVDF+ EV+ AL +G L+VVD +G Sbjct: 64 VRV-----------TYRAKDGEEYVFHLIDTPGHVDFTYEVSRALAAVEGVLLVVDASQG 112 Query: 135 VCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVES 184 V +T AL + VINK+D ++ + + Sbjct: 113 VEAETLAKFYMALEHGHVIIPVINKIDLPNARPLEVALEVEEVLGLPADE 162 Score = 66.1 bits (159), Expect = 6e-11, Method: Composition-based stats. Identities = 81/417 (19%), Positives = 146/417 (35%), Gaps = 54/417 (12%) Query: 303 LEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPAD 362 LE+ L+ +E K + +LE IV +P P Sbjct: 146 LEVALEVEEVLGLPADEAIFASGKTGEGVEEILEAIVQRIPPPKG--------------- 190 Query: 363 DANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGK 422 DP+A L + V + +G + R+F G V+ G ++RI Y GK Sbjct: 191 ----------DPEAPLKALIFDSVYDAYQG-VIPYLRLFEGRVRPGDRIRI----YSTGK 235 Query: 423 KDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLK---TGTLTTSETAHNMK 479 + + +V + + + + AG + LV + + T+T ++ Sbjct: 236 E-----FTVDKVGVFTPQGLVATEALEAGEVGWLVAAIRDIHDVQVGDTITLADRPTPSP 290 Query: 480 VMKF-SVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAG-----T 533 F PVV + ++ D KL + L++L +D + T+ ES + G Sbjct: 291 YPGFRPAKPVVFAGLYPVDSGDYGKLRDALEKLKLNDAAL-TFEPESSTALGFGFRCGFL 349 Query: 534 GELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPN---KHNRIYLKA 590 G LH EI + LE + G+ L + P V Y+ V +S + +P RI Sbjct: 350 GLLHAEIVQERLEREF-GLSLIATAPSVVYK--VRLKSGEEVEVHNPADLPDPTRIEEIL 406 Query: 591 EPIDEEVSLAIENGIINPRD-DFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQ 649 EP + E + + + R R++ +Y ++ P D+ Sbjct: 407 EPYVKLTIFTPEEYVGSLMQLLQEKRGRLVNMNYLPGAQKRVELVYEAPFAEILYDFHDR 466 Query: 650 TKAVQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQII 706 K+V + D A ++ + V+ L H + + I+ Sbjct: 467 LKSVSRGYASMDYEQAGYRPGDL--VKVNVLVHGEVVDALTFIAHREKAYTMARAIV 521 Score = 54.5 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 41/101 (40%), Gaps = 4/101 (3%) Query: 724 IQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFT-VKAYLPVNE-SFGFT 781 I EP + I PE+ VG + +L +KRG++V+ PG + P E + F Sbjct: 405 ILEPYVKLTIFTPEEYVGSLMQLLQEKRGRLVNMNYLPGAQKRVELVYEAPFAEILYDFH 464 Query: 782 GELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAA 822 L+ + G A M ++ D + V+ A Sbjct: 465 DRLKSVSRGYA--SMDYEQAGYRPGDLVKVNVLVHGEVVDA 503 >4NCL-A nrPDB Length = 457 Score = 156 bits (394), Expect = 4e-38, Method: Composition-based stats. Identities = 48/191 (25%), Positives = 83/191 (43%), Gaps = 21/191 (10%) Query: 11 SLMDKVTNVRN--MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGI 68 S M+K N+R+ ++ HVD GK+ L D + Q + + GEA GI Sbjct: 1 SHMNK-DNLRSPICCILGHVDTGKTKLLDKIRQ-----TNVQEGEAG-----------GI 43 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKTDGNSFL--INLIDSPGHVDFSSEVTAALRVTDGAL 126 T + A E + + + + + +ID+PGH FS+ + + + A+ Sbjct: 44 TQQIGATYFPVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNIAI 103 Query: 127 VVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVN 186 +VVD + G+ QT LR + VV +NK+DR ++ ++FA ++V Sbjct: 104 LVVDIMHGLEPQTIESLRLLRERKTPFVVALNKIDRLYGWKKIENNGFRESFALQNKAVQ 163 Query: 187 VIVSTYADEVL 197 D+V Sbjct: 164 NEFRNRLDQVK 174 >4N3G-A nrPDB Length = 603 Score = 156 bits (393), Expect = 5e-38, Method: Composition-based stats. Identities = 48/191 (25%), Positives = 83/191 (43%), Gaps = 21/191 (10%) Query: 11 SLMDKVTNVRN--MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGI 68 S M+K N+R+ ++ HVD GK+ L D + Q + + GEA GI Sbjct: 1 SHMNK-DNLRSPICCILGHVDTGKTKLLDKIRQ-----TNVQEGEAG-----------GI 43 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKTDGNSFL--INLIDSPGHVDFSSEVTAALRVTDGAL 126 T + A E + + + + + +ID+PGH FS+ + + + A+ Sbjct: 44 TQQIGATYFPVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNIAI 103 Query: 127 VVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVN 186 +VVD + G+ QT LR + VV +NK+DR ++ ++FA ++V Sbjct: 104 LVVDIMHGLEPQTIESLRLLRERKTPFVVALNKIDRLYGWKKIENNGFRESFALQNKAVQ 163 Query: 187 VIVSTYADEVL 197 D+V Sbjct: 164 NEFRNRLDQVK 174 >1EFM-A nrPDB Length = 379 Score = 152 bits (384), Expect = 5e-37, Method: Composition-based stats. Identities = 40/196 (20%), Positives = 74/196 (37%), Gaps = 36/196 (18%) Query: 10 RSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGIT 69 + ++ N+ I HVDHGK+TLT ++ +++ G A RGIT Sbjct: 2 KEKFERTKPHVNVGTIGHVDHGKTTLTAAI---TTVLAKTYGGAA-----------RGIT 47 Query: 70 IKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVV 129 I ++ + D + +D PGH D+ + DGA++VV Sbjct: 48 INTSHVEY----------------DTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVV 91 Query: 130 DTIEGVCVQTETVLRQALGERIK-PVVVINKVDR-----ALLELQVSKEDLYQTFARTVE 183 +G QT + + +V +NK D L +++ +L + + Sbjct: 92 AATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGD 151 Query: 184 SVNVIVSTYADEVLGD 199 ++ + + GD Sbjct: 152 DTPIVRGSALKALEGD 167 >4TN1-B nrPDB Length = 345 Score = 151 bits (382), Expect = 9e-37, Method: Composition-based stats. Identities = 46/191 (24%), Positives = 81/191 (42%), Gaps = 21/191 (10%) Query: 11 SLMDKVTNVRN--MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGI 68 M+K N+R+ ++ HV GK+ L D + Q + + GEA GI Sbjct: 1 GHMNK-DNLRSPICCILGHVRTGKTKLLDKIRQ-----TNVQEGEAG-----------GI 43 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKTDGNSFL--INLIDSPGHVDFSSEVTAALRVTDGAL 126 T + A E + + + + + +ID+PGH FS+ + + + A+ Sbjct: 44 TQQIGATYFPVEAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNIAI 103 Query: 127 VVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVN 186 +VVD + G+ QT LR + VV +NK+DR ++ ++FA ++V Sbjct: 104 LVVDIMHGLEPQTIESLRLLRERKTPFVVALNKIDRLYGWKKIENNGFRESFALQNKAVQ 163 Query: 187 VIVSTYADEVL 197 D+V Sbjct: 164 NEFRNRLDQVK 174 >1G7S-A nrPDB Length = 594 Score = 141 bits (355), Expect = 1e-33, Method: Composition-based stats. Identities = 48/181 (26%), Positives = 79/181 (43%), Gaps = 18/181 (9%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 +SV+ HVDHGK+TL D + R +++ +AG GIT A + ++ Sbjct: 8 VSVLGHVDHGKTTLLDHI--RGSAVASREAG--------------GITQHIGATEIPMDV 51 Query: 82 SDEDVKEIKQKTDGNSFL--INLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 + + +K L + ID+PGH F++ + D A+++VD EG QT Sbjct: 52 IEGICGDFLKKFSIRETLPGLFFIDTPGHEAFTTLRKRGGALADLAILIVDINEGFKPQT 111 Query: 140 ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGD 199 + L R VV NK+DR +TF++ V + T E++G Sbjct: 112 QEALNILRMYRTPFVVAANKIDRIHGWRVHEGRPFMETFSKQDIQVQQKLDTKVYELVGK 171 Query: 200 V 200 + Sbjct: 172 L 172 >3WXM-A nrPDB Length = 447 Score = 141 bits (354), Expect = 2e-33, Method: Composition-based stats. Identities = 53/213 (24%), Positives = 79/213 (37%), Gaps = 46/213 (21%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGEARF-----TDTRKDEQE 65 N+ VI HVDHGKSTL L+ R G I A G+ F D K+E+E Sbjct: 11 NLVVIGHVDHGKSTLVGHLLYRLGYIEEKKLKELEEQAKSRGKESFKFAWILDKMKEERE 70 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RGITI T + + ++ +ID+PGH DF + D A Sbjct: 71 RGITIDLTFMKFET----------------KKYVFTIIDAPGHRDFVKNMITGASQADAA 114 Query: 126 LVVVDTIEG-------VCVQTETVLRQALGERI-KPVVVINKVDRALLELQVSKEDLYQT 177 ++VV +G QT L A I + +V +NK+D + + Sbjct: 115 ILVVSARKGEFEAGMSTEGQTREHLLLARTMGIEQIIVAVNKMDAPDVNYDQ------KR 168 Query: 178 FARTVESVNVIVSTYADEVLGDVQVYPARGTVA 210 + V + + +V + P Sbjct: 169 YEFVVSVLKKFMKGLGYQV-DKIPFIPVSAWKG 200 >4UJC-AB nrPDB Length = 627 Score = 138 bits (348), Expect = 7e-33, Method: Composition-based stats. Identities = 67/350 (19%), Positives = 117/350 (33%), Gaps = 50/350 (14%) Query: 15 KVTNVRN--MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKS 72 +R + V+ HVD GK+ + D L R + +AG GIT + Sbjct: 32 NTEKLRAPVICVLGHVDTGKTKILDKL--RHTHVQDGEAG--------------GITQQI 75 Query: 73 TAISLYSEMSDEDVKEIKQKTDGNSFL--INLIDSPGHVDFSSEVTAALRVTDGALVVVD 130 A ++ E +E K IK N + + +ID+PGH FS+ + D A++VVD Sbjct: 76 GATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVD 135 Query: 131 TIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVS 190 + G+ QT + ++ +V +NK+DR + D+ T + ++ Sbjct: 136 IMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFE 195 Query: 191 TYA--------------------DEVLGDVQVYPARGTVAFGSGLHGWAFT--------- 221 A + V + P G G + Sbjct: 196 ERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSK 255 Query: 222 -IRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDP 280 + A+ V M N + K+ P+ +L P Sbjct: 256 RLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPP 315 Query: 281 IFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPA 330 + ++K + + ++I+ K EK L G LL +P Sbjct: 316 PMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPV 365 >1JNY-A nrPDB Length = 435 Score = 138 bits (348), Expect = 7e-33, Method: Composition-based stats. Identities = 56/224 (25%), Positives = 86/224 (38%), Gaps = 48/224 (21%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEAR---------------FTDTRKDEQE 65 N+ VI HVDHGKSTL L+ G I EA D K+E+E Sbjct: 8 NLIVIGHVDHGKSTLVGRLLMDRGFIDEKTVKEAEEAAKKLGKESEKFAFLLDRLKEERE 67 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RG+TI T + + + +ID+PGH DF + D A Sbjct: 68 RGVTINLTFMRFET----------------KKYFFTIIDAPGHRDFVKNMITGASQADAA 111 Query: 126 LVVVDTIEG-------VCVQTETVLRQALGERI-KPVVVINKVDRALLELQVSKEDLYQT 177 ++VV +G V QT + A + + +V +NK+D L D + Sbjct: 112 ILVVSAKKGEYEAGMSVEGQTREHIILAKTMGLDQLIVAVNKMD-----LTEPPYD-EKR 165 Query: 178 FARTVESVNVIVSTYA---DEVLGDVQVYPARGTVAFGSGLHGW 218 + V+ V+ + +Y ++V V P+ + S W Sbjct: 166 YKEIVDQVSKFMRSYGFNTNKVRFVPVVAPSGDNITHKSENMKW 209 >3IZY-P nrPDB Length = 537 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 101/278 (36%), Gaps = 45/278 (16%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK+TL D L R ++A +AG GIT A + Sbjct: 7 VTIMGHVDHGKTTLLDKL--RKTQVAAMEAG--------------GITQHIGAFLV---- 46 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 + + I +D+PGH FS+ +VTD ++VV +GV QT Sbjct: 47 -----------SLPSGEKITFLDTPGHAAFSAMRARGTQVTDIVILVVAADDGVMKQTVE 95 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLG-DV 200 ++ A + V+ INK D+A + + K++L + +V+ Y +V V Sbjct: 96 SIQHAKDAHVPIVLAINKCDKAEADPEKVKKELL--------AYDVVCEDYGGDVQAVHV 147 Query: 201 QVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNK 260 +A A + A G D P T + Sbjct: 148 SALTGENMMALAEATIALAEMLELKADPTGAVEGTVIESFT-----DKGRGPVTTAIIQR 202 Query: 261 DTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPV 298 T +G L + + +F +N +PV Sbjct: 203 GTLRKGSILVAGKSWAKVRLMFDENGRAVNEAYPSMPV 240 >6GB2-BC nrPDB Length = 657 Score = 136 bits (343), Expect = 3e-32, Method: Composition-based stats. Identities = 46/189 (24%), Positives = 79/189 (41%), Gaps = 43/189 (22%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK+TL D R ++A + G GIT A + Sbjct: 113 VTIMGHVDHGKTTLLDK--FRKTQVAAVETG--------------GITQHIGAFLV---- 152 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 + + I +D+PGH FS+ +VTD ++VV +GV QT Sbjct: 153 -----------SLPSGEKITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVE 201 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQ 201 ++ A ++ ++ +NK D+A + + K++L + +V+ Y GDVQ Sbjct: 202 SIQHAKDAQVPIILAVNKCDKAEADPEKVKKELL--------AYDVVCEDYG----GDVQ 249 Query: 202 VYPARGTVA 210 P Sbjct: 250 AVPVSALTG 258 >4NCF-A nrPDB Length = 457 Score = 136 bits (343), Expect = 3e-32, Method: Composition-based stats. Identities = 41/193 (21%), Positives = 78/193 (40%), Gaps = 19/193 (9%) Query: 11 SLMDKVTNVRNMS-VIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGIT 69 S M+K + ++ HVD GK+ L D + Q + +AG GIT Sbjct: 1 SHMNKKDLRSPICCILGHVDTGKTKLLDKIRQ--TNVQGGEAG--------------GIT 44 Query: 70 IKSTAISLYSEMSDEDVKEIKQKTDGNSFLINL--IDSPGHVDFSSEVTAALRVTDGALV 127 + A + K + + + L ID+PGH FS+ + + + A++ Sbjct: 45 QQIGATYFPIDAIKAKTKVMAEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIAIL 104 Query: 128 VVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNV 187 V+D + G+ QT ++ + VV +NK+DR + +FA+ +V Sbjct: 105 VIDIMHGLEQQTIESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQE 164 Query: 188 IVSTYADEVLGDV 200 + ++ ++ Sbjct: 165 EFQSRYSKIQLEL 177 >4C0S-A nrPDB Length = 463 Score = 136 bits (341), Expect = 5e-32, Method: Composition-based stats. Identities = 55/221 (24%), Positives = 79/221 (35%), Gaps = 46/221 (20%) Query: 13 MDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGEARF-----T 57 M K N+ VI HVD GKST T L+ + G I AA+ G+ F Sbjct: 1 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL 60 Query: 58 DTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTA 117 D K E+ERGITI + K + + I +ID+PGH DF + Sbjct: 61 DKLKAERERGITIDIS----------------LWKFETTKYYITIIDAPGHRDFIKNMIT 104 Query: 118 ALRVTDGALVVVDTIEG-VCV------QTETVLRQALGERIK-PVVVINKVDRALLELQV 169 D A+++V G QT A +K +V +NK+D Sbjct: 105 GTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMD------ST 158 Query: 170 SKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVA 210 + + V+ V+ + V P G Sbjct: 159 EPAYSEKRYDEIVKEVSAYIKKIGYNPAT-VPFVPISGWHG 198 >2LKD-A nrPDB Length = 178 Score = 135 bits (340), Expect = 6e-32, Method: Composition-based stats. Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 32/155 (20%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK+TL D++ R ++ +AG GIT A + Sbjct: 11 VTIMGHVDHGKTTLLDAI--RHSKVTEQEAG--------------GITQHIGAYQV---- 50 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 N I +D+PGH F++ +VTD ++VV +GV QT Sbjct: 51 ------------TVNDKKITFLDTPGHEAFTTMRARGAQVTDIVILVVAADDGVMPQTVE 98 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 + A + +V INK+D+ ++L + Sbjct: 99 AINHAKAANVPIIVAINKMDKPEANPDRVMQELME 133 >2B7C-A nrPDB Length = 458 Score = 135 bits (340), Expect = 7e-32, Method: Composition-based stats. Identities = 52/221 (23%), Positives = 78/221 (35%), Gaps = 48/221 (21%) Query: 13 MDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGEARF-----T 57 M K + N+ VI HVD GKST T L+ + G I AA+ G+ F Sbjct: 1 MGKEKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVL 60 Query: 58 DTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTA 117 D K E+ERGITI K + + + +ID+PGH DF + Sbjct: 61 DKLKAERERGITIDIA----------------LWKFETPKYQVTVIDAPGHRDFIKNMIT 104 Query: 118 ALRVTDGALVVVDTIEG-VCV------QTETVLRQALGERI-KPVVVINKVDRALLELQV 169 D A++++ G QT A + + +V +NK+D + Sbjct: 105 GTSQADCAILIIAGGVGEFEAGISKDGQTREHALLAFTLGVRQLIVAVNKMDSVKWD--- 161 Query: 170 SKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVA 210 F V+ + + V P G Sbjct: 162 -----ESRFQEIVKETSNFIKKVGYNPKT-VPFVPISGWNG 196 >4V8Y-CP nrPDB Length = 339 Score = 135 bits (338), Expect = 1e-31, Method: Composition-based stats. Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 18/181 (9%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++ HVD GK+ L D + Q + +AG GIT + A + Sbjct: 8 CCILGHVDTGKTKLLDKIRQ--TNVQGGEAG--------------GITQQIGATYFPIDA 51 Query: 82 SDEDVKEIKQKTDGNSFLINL--IDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 K + + + L ID+PGH FS+ + + + A++V+D + G+ QT Sbjct: 52 IKAKTKVMAEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQT 111 Query: 140 ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGD 199 ++ + VV +NK+DR + +FA+ +V + ++ + Sbjct: 112 IESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQSRYSKIQLE 171 Query: 200 V 200 + Sbjct: 172 L 172 >5FG3-A nrPDB Length = 623 Score = 134 bits (337), Expect = 1e-31, Method: Composition-based stats. Identities = 50/191 (26%), Positives = 84/191 (43%), Gaps = 20/191 (10%) Query: 14 DKVTNVRN--MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK 71 D +R + V+ HVDHGK+TL D + + A ++A +AG GIT Sbjct: 9 DGERRLRQPIVVVLGHVDHGKTTLLDKIRRTA--VAAKEAG--------------GITQH 52 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFL--INLIDSPGHVDFSSEVTAALRVTDGALVVV 129 A + +++ ++ + +K+ + + ID+PGH FS+ V D A++VV Sbjct: 53 IGASIVPADVIEKIAEPLKKVIPVKLVIPGLLFIDTPGHELFSNLRRRGGSVADFAILVV 112 Query: 130 DTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIV 189 D +EG QT L R+ ++ NK+DR +T R V I+ Sbjct: 113 DIMEGFKPQTYEALELLKERRVPFLIAANKIDRIPGWKPNPDAPFIETIRRQDPKVREIL 172 Query: 190 STYADEVLGDV 200 E++G + Sbjct: 173 EQRVYEIVGKM 183 >5LZS-jj nrPDB Length = 462 Score = 134 bits (337), Expect = 1e-31, Method: Composition-based stats. Identities = 54/221 (24%), Positives = 80/221 (36%), Gaps = 46/221 (20%) Query: 13 MDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGEARF-----T 57 M K N+ VI HVD GKST T L+ + G I AA+ G+ F Sbjct: 1 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL 60 Query: 58 DTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTA 117 D K E+ERGITI + K + + + + +ID+PGH DF + Sbjct: 61 DKLKAERERGITIDIS----------------LWKFETSKYYVTIIDAPGHRDFIKNMIT 104 Query: 118 ALRVTDGALVVVDTIEG-VCV------QTETVLRQALGERIK-PVVVINKVDRALLELQV 169 D A+++V G QT A +K +V +NK+D Sbjct: 105 GTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMD------ST 158 Query: 170 SKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVA 210 + + V+ V+ + V P G Sbjct: 159 EPPYSQKRYEEIVKEVSTYIKKIGYNPDT-VAFVPISGWNG 198 >3WY9-A nrPDB Length = 434 Score = 134 bits (337), Expect = 2e-31, Method: Composition-based stats. Identities = 71/321 (22%), Positives = 110/321 (34%), Gaps = 43/321 (13%) Query: 13 MDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAA------KAGE-------ARFTDT 59 M K N+ I HVDHGKST L+ G I + GE A D Sbjct: 1 MPKEKPHVNIVFIGHVDHGKSTTIGRLLYDTGNIPETIIKKFEEMGEKGKSFKFAWVMDR 60 Query: 60 RKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAAL 119 K+E+ERGITI + I +ID+PGH DF + Sbjct: 61 LKEERERGITIDVAHTKFET----------------PHRYITIIDAPGHRDFVKNMITGA 104 Query: 120 RVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVV-INKVDRALLELQVSKEDLYQTF 178 D A++VV +GV QT+ A IK ++V INK+D + +V F Sbjct: 105 SQADAAVLVVAATDGVMPQTKEHAFLARTLGIKHIIVTINKMDMVNYDQKV--------F 156 Query: 179 ARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGV-DK 237 + V ++ T D V P T + + Sbjct: 157 EKVKAQVEKLLKTLG---YKDFPVIPTSAWNGDNVVKKSDKMPWYNGPTLIEALDQIPEP 213 Query: 238 AKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLE-RAFNMFILDPIFRLFTAIMNFKKDEI 296 K +D+ + + K + + + ++ I +P +F + + I Sbjct: 214 EKPIDKPLRIPIQDVYSIKGVGTVPVGRVETGKLKVGDVVIFEPASTIFHKPIQGEVKSI 273 Query: 297 PVLLEKLEIVLKGDEKDLEGK 317 + E L+ L GD + Sbjct: 274 EMHHEPLQEALPGDNIGFNVR 294 >3WBI-A nrPDB Length = 606 Score = 133 bits (335), Expect = 3e-31, Method: Composition-based stats. Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 18/181 (9%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++ HVD GK+ L D + Q + +AG GIT + A + Sbjct: 12 CCILGHVDTGKTKLLDKIRQ--TNVQGGEAG--------------GITQQIGATYFPIDA 55 Query: 82 SDEDVKEIKQKTDGNSFLINL--IDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 K + + + L ID+PGH FS+ + + + A++V+D + G+ QT Sbjct: 56 IKAKTKVMAEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQT 115 Query: 140 ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGD 199 ++ + VV +NK+DR + +FA+ +V + ++ + Sbjct: 116 IESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQSRYSKIQLE 175 Query: 200 V 200 + Sbjct: 176 L 176 >5YT0-A nrPDB Length = 364 Score = 133 bits (335), Expect = 3e-31, Method: Composition-based stats. Identities = 50/191 (26%), Positives = 84/191 (43%), Gaps = 20/191 (10%) Query: 14 DKVTNVRN--MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK 71 D +R + V+ HVDHGK+TL D + + A ++A +AG GIT Sbjct: 9 DGERRLRQPIVVVLGHVDHGKTTLLDKIRRTA--VAAKEAG--------------GITQH 52 Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFL--INLIDSPGHVDFSSEVTAALRVTDGALVVV 129 A + +++ ++ + +K+ + + ID+PGH FS+ V D A++VV Sbjct: 53 IGASIVPADVIEKIAEPLKKVIPVKLVIPGLLFIDTPGHELFSNLRRRGGSVADFAILVV 112 Query: 130 DTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIV 189 D +EG QT L R+ ++ NK+DR +T R V I+ Sbjct: 113 DIMEGFKPQTYEALELLKERRVPFLIAANKIDRIPGWKPNPDAPFIETIRRQDPKVREIL 172 Query: 190 STYADEVLGDV 200 E++G + Sbjct: 173 EQRVYEIVGKM 183 >4V8Z-CV nrPDB Length = 586 Score = 132 bits (331), Expect = 8e-31, Method: Composition-based stats. Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 18/181 (9%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++ HVD GK+ L D + Q + +AG GIT + A + Sbjct: 8 CCILGHVDTGKTKLLDKIRQ--TNVQGGEAG--------------GITQQIGATYFPIDA 51 Query: 82 SDEDVKEIKQKTDGNSFLINL--IDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 K + + + L ID+PGH FS+ + + + A++V+D + G+ QT Sbjct: 52 IKAKTKVMAEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHGLEQQT 111 Query: 140 ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGD 199 ++ + VV +NK+DR + +FA+ +V + ++ + Sbjct: 112 IESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQSRYSKIQLE 171 Query: 200 V 200 + Sbjct: 172 L 172 >4AC9-A nrPDB Length = 482 Score = 131 bits (330), Expect = 8e-31, Method: Composition-based stats. Identities = 46/167 (27%), Positives = 72/167 (43%), Gaps = 25/167 (14%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ + H+DHGK+TL+ L + A + D + Q+RGITI + E Sbjct: 21 NLGIFGHIDHGKTTLSKVLTEIASTSAH---------DKLPESQKRGITIDIGFSAFKLE 71 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTE 140 ++ I L+D+PGH D V +A + D AL+VVD EG QT Sbjct: 72 ----------------NYRITLVDAPGHADLIRAVVSAADIIDLALIVVDAKEGPKTQTG 115 Query: 141 TVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNV 187 + I +VVI K D A E E + ++ ++ ++ Sbjct: 116 EHMLILDHFNIPIIVVITKSDNAGTEEIKRTEMIMKSILQSTHNLKN 162 >2D74-A nrPDB Length = 419 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 48/186 (25%), Positives = 74/186 (39%), Gaps = 28/186 (15%) Query: 13 MDKVTNVR----NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGI 68 M + R N+ ++ HVDHGK+TLT +L +TDT +E RGI Sbjct: 1 MGEKRKTRQAEVNIGMVGHVDHGKTTLTKALT-------------GVWTDTHSEELRRGI 47 Query: 69 TIKS----TAISLYSEMSDEDVKEIKQKTDGNS---FLINLIDSPGHVDFSSEVTAALRV 121 TIK I S I + ++ IDSPGH + + A + Sbjct: 48 TIKIGFADAEIRRCSNCGRYSTSPICPYCGHETEFIRRVSFIDSPGHEALMTTMLAGASL 107 Query: 122 TDGALVVVDTIEG-VCVQTETVLRQALGERIK-PVVVINKVDRALLELQVSKEDLYQTFA 179 DGA++V+ E QT L K ++ NK+ L++ + + E+ Q Sbjct: 108 MDGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKI--ELVDKEKALENYRQIKE 165 Query: 180 RTVESV 185 +V Sbjct: 166 FIKGTV 171 >1S0U-A nrPDB Length = 408 Score = 127 bits (319), Expect = 2e-29, Method: Composition-based stats. Identities = 40/198 (20%), Positives = 77/198 (38%), Gaps = 24/198 (12%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLY-- 78 N+ ++ HVDHGK++LT +L +TD +E RGI+I+ Sbjct: 10 NIGMVGHVDHGKTSLTKALT-------------GVWTDRHSEELRRGISIRLGYADCEIR 56 Query: 79 --SEMSDEDVKEIKQKTDGNS---FLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIE 133 + K + ++ +DSPGH + + + + DGA++V+ E Sbjct: 57 KCPQCGTYTTKPRCPNCLAETEFLRRVSFVDSPGHETLMATMLSGASLMDGAILVIAANE 116 Query: 134 G-VCVQTETVLRQALGERI-KPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 QT+ L I K ++V NK+D L++ + ++E+ Q ++ Sbjct: 117 PCPQPQTKEHLMALEILGIDKIIIVQNKID--LVDEKQAEENYEQIKEFVKGTIAENAPI 174 Query: 192 YADEVLGDVQVYPARGTV 209 + + + Sbjct: 175 IPISAHHEANIDVLLKAI 192 >3PEN-A nrPDB Length = 403 Score = 126 bits (317), Expect = 3e-29, Method: Composition-based stats. Identities = 48/171 (28%), Positives = 78/171 (45%), Gaps = 14/171 (8%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ V+ HVDHGK+TL ++ GI ++ K G A T+ E + T S S Sbjct: 10 NIGVVGHVDHGKTTLVQAI---TGIWTSKKLGYAE-TNIGVCESCKKPEAYVTEPSCKSC 65 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG-VCVQT 139 SD++ K ++ I+ ID+PGH + + + + DGA++VV E QT Sbjct: 66 GSDDEPKFLR--------RISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQT 117 Query: 140 ETVLRQALGERIK-PVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIV 189 +K ++V NKVD E +S+ + F + + NV + Sbjct: 118 REHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPI 168 >4ZU9-A nrPDB Length = 582 Score = 125 bits (313), Expect = 8e-29, Method: Composition-based stats. Identities = 42/169 (24%), Positives = 71/169 (42%), Gaps = 29/169 (17%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 + HVDHGK+TL +L TD +E++RG++I + Sbjct: 6 FATAGHVDHGKTTLIKTLT-------------GIDTDRLPEEKKRGLSIDIGFAYI---- 48 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 + + +ID PGH F A + G ++VVD EG+ QT Sbjct: 49 ----------DFPDINTRLEIIDVPGHERFIKNAIAGICSASGLILVVDPNEGIMPQTIE 98 Query: 142 VLRQALGERIKP-VVVINKVDRALLEL-QVSKEDLYQTFARTVESVNVI 188 LR A IK + V+ K+D+ EL +++E+L + ++ ++ Sbjct: 99 HLRVAKSFGIKHGIAVLTKMDKVDEELAHIAEEELIAFLEKEEMNMEIV 147 >5IZL-A nrPDB Length = 616 Score = 122 bits (306), Expect = 5e-28, Method: Composition-based stats. Identities = 39/160 (24%), Positives = 64/160 (40%), Gaps = 18/160 (11%) Query: 11 SLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITI 70 S M N+ V+ H+D GK+ L +L A + D + +ERGIT+ Sbjct: 19 SHMAGRRVNVNVGVLGHIDSGKTALARALSTTASTAA---------FDKQPQSRERGITL 69 Query: 71 KST--------AISLYSEMSDEDVKEIKQKTDGNSFL-INLIDSPGHVDFSSEVTAALRV 121 L S + + + G L + L+D PGH + ++ Sbjct: 70 DLGFSCFSVPLPARLRSSLPEFQAAPEAEPEPGEPLLQVTLVDCPGHASLIRTIIGGAQI 129 Query: 122 TDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVD 161 D ++V+D +G+ Q+ L K VVV+NK+D Sbjct: 130 IDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKID 169 >5LZY-jj nrPDB Length = 710 Score = 122 bits (306), Expect = 6e-28, Method: Composition-based stats. Identities = 44/170 (25%), Positives = 68/170 (40%), Gaps = 39/170 (22%) Query: 17 TNVRNMSVIAHVDHGKSTLTDSLVQRAGIIS----------AAKAGEARF-----TDTRK 61 + N+ VI HVD GKSTL ++ G I+ + KAG+A F D Sbjct: 284 KQLLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAYAWVLDETG 343 Query: 62 DEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRV 121 +E+ERG+T+ + + +I L+D+PGH DF + Sbjct: 344 EERERGVTMDVGMTKFET----------------TTKVITLMDAPGHKDFIPNMITGAAQ 387 Query: 122 TDGALVVVDTI-----EGVCV--QTETVLRQALGERIKPV-VVINKVDRA 163 D A++VVD G QT + + V +NK+D+ Sbjct: 388 ADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQV 437 >3MCA-A nrPDB Length = 592 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 49/217 (22%), Positives = 82/217 (37%), Gaps = 44/217 (20%) Query: 15 KVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE---------------ARFTDT 59 V ++ V HVD GKST+ ++ G I++ + A DT Sbjct: 173 NPKPVVHLVVTGHVDSGKSTMLGRIMFELGEINSRSMQKLHNEAANSGKGSFSYAWLLDT 232 Query: 60 RKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAAL 119 ++E+ RG+T+ + + S+ ++ D+PGH DF S + A Sbjct: 233 TEEERARGVTMDVASTTFESDKKIYEIG----------------DAPGHRDFISGMIAGA 276 Query: 120 RVTDGALVVVDTIE-----GVCV--QTETVLRQALGERIKPVVV-INKVDRALLELQVSK 171 D A++VVD+ + G QT I +VV +NK+D L Sbjct: 277 SSADFAVLVVDSSQNNFERGFLENGQTREHAYLLRALGISEIVVSVNKLD-----LMSWS 331 Query: 172 EDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGT 208 ED +Q V + + + + V + GT Sbjct: 332 EDRFQEIKNIVSDFLIKMVGFKTSNVHFVPISAISGT 368 >1ZO1-I nrPDB Length = 501 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 32/155 (20%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK++L + + R+ +++ +AG GIT A + +E Sbjct: 7 VTIMGHVDHGKTSLLEYI--RSTKVASGEAG--------------GITQHIGAYHVETEN 50 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 +I +D+PGH F+S + TD ++VV +GV QT Sbjct: 51 G----------------MITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIE 94 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 ++ A ++ VV +NK+D+ + K +L Q Sbjct: 95 AIQHAKAAQVPVVVAVNKIDKPEADPDRVKNELSQ 129 >3J4J-A nrPDB Length = 569 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 42/183 (22%), Positives = 74/183 (40%), Gaps = 36/183 (19%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 + ++ HVDHGK+TL D L R I+ +AG GIT A + + Sbjct: 76 VVIMGHVDHGKTTLLDYL--RKSRIAEKEAG--------------GITQHVGAFEVKT-- 117 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 + ID+PGH F++ +V D A++V+ +G+ QTE Sbjct: 118 --------------PQGTVVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQTEE 163 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQT----FARTVESVNVIVSTYADEVL 197 + A K + INK+D + + K L + +++ + +S + + Sbjct: 164 AIAHAKAAGAKLIFAINKIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGV 223 Query: 198 GDV 200 D+ Sbjct: 224 QDL 226 >4KJZ-A nrPDB Length = 473 Score = 117 bits (293), Expect = 2e-26, Method: Composition-based stats. Identities = 42/183 (22%), Positives = 74/183 (40%), Gaps = 36/183 (19%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 + ++ HVDHGK+TL D L R I+ +AG GIT A + + Sbjct: 75 VVIMGHVDHGKTTLLDYL--RKSRIAEKEAG--------------GITQHVGAFEVKT-- 116 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 + ID+PGH F++ +V D A++V+ +G+ QTE Sbjct: 117 --------------PQGTVVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQTEE 162 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQT----FARTVESVNVIVSTYADEVL 197 + A K + INK+D + + K L + +++ + +S + + Sbjct: 163 AIAHAKAAGAKLIFAINKIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGV 222 Query: 198 GDV 200 D+ Sbjct: 223 QDL 225 >4B44-A nrPDB Length = 363 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 42/183 (22%), Positives = 74/183 (40%), Gaps = 36/183 (19%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 + ++ HVDHGK+TL D L R I+ +AG GIT A + + Sbjct: 76 VVIMGHVDHGKTTLLDYL--RKSRIAEKEAG--------------GITQHVGAFEVKT-- 117 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 + ID+PGH F++ +V D A++V+ +G+ QTE Sbjct: 118 --------------PQGTVVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGIMPQTEE 163 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQT----FARTVESVNVIVSTYADEVL 197 + A K + INK+D + + K L + +++ + +S + + Sbjct: 164 AIAHAKAAGAKLIFAINKIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGV 223 Query: 198 GDV 200 D+ Sbjct: 224 QDL 226 >3JCN-b nrPDB Length = 890 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 40/155 (25%), Positives = 71/155 (45%), Gaps = 32/155 (20%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ HVDHGK++L D + R+ +++ +AG GIT A + +E Sbjct: 394 VTIMGHVDHGKTSLLDYI--RSTKVASGEAG--------------GITQHIGAYHVETEN 437 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 +I +D+PGH F+S + TD ++VV +GV QT Sbjct: 438 G----------------MITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIE 481 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 ++ A ++ VV +NK+D+ + K +L Q Sbjct: 482 AIQHAKAAQVPVVVAVNKIDKPEADPDRVKNELSQ 516 >5LZD-z nrPDB Length = 614 Score = 115 bits (287), Expect = 8e-26, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 91/259 (35%), Gaps = 42/259 (16%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++ HVDHGK+TL ++ D +E++RG+TI Y Sbjct: 3 IATAGHVDHGKTTLLQAIT-------------GVNADRLPEEKKRGMTIDLGYA--YWPQ 47 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 D V ID PGH F S + A + D AL+VV +GV QT Sbjct: 48 PDGRVPG-------------FIDVPGHEKFLSNMLAGVGGIDHALLVVACDDGVMAQTRE 94 Query: 142 VLRQALGERIKPV-VVINKVDRALL----ELQVSKEDLYQTFARTVESVNVIVSTYA--- 193 L + V + K DR E++ +++ + + + + +T Sbjct: 95 HLAILQLTGNPMLTVALTKADRVDEARVDEVERQVKEVLREYGFAEAKLFITAATEGRGM 154 Query: 194 DEVLGDVQVYPARGTVAFGSGLHGW--AFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFN 251 D + + P R + S AFT++ + K+ D LW Sbjct: 155 DALREHLLQLPEREHASQHSFRLAIDRAFTVKGAGLVVTGTALSGEVKVGDSLW----LT 210 Query: 252 PKTKKWTNKDTDAEGKPLE 270 K + A+ +P E Sbjct: 211 GVNKPMRVRALHAQNQPTE 229 >2HDN-B nrPDB Length = 335 Score = 113 bits (281), Expect = 5e-25, Method: Composition-based stats. Identities = 26/139 (18%), Positives = 50/139 (35%), Gaps = 22/139 (15%) Query: 67 GITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGAL 126 GITI ++ + D + +D PGH D+ + DGA+ Sbjct: 1 GITINTSHVEY----------------DTPTRHYAHVDCPGHADYVKNMITGAAQMDGAI 44 Query: 127 VVVDTIEGVCVQTETVLRQALGERIK-PVVVINKVDR-----ALLELQVSKEDLYQTFAR 180 +VV +G QT + + +V +NK D L +++ +L + Sbjct: 45 LVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDF 104 Query: 181 TVESVNVIVSTYADEVLGD 199 + ++ + + GD Sbjct: 105 PGDDTPIVRGSALKALEGD 123 >4D61-i nrPDB Length = 426 Score = 109 bits (272), Expect = 4e-24, Method: Composition-based stats. Identities = 38/217 (17%), Positives = 71/217 (32%), Gaps = 45/217 (20%) Query: 17 TNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEAR---------------FTDTRK 61 N+ I HVD GKST+ ++ G++ + DT + Sbjct: 1 KEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQ 60 Query: 62 DEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRV 121 +E+++G T++ +E ++D+PGH F + Sbjct: 61 EERDKGKTVEVGRAYFETE----------------KKHFTILDAPGHKSFVPNMIGGASQ 104 Query: 122 TDGALVVVDTIEG-VCV------QTETVLRQALGERIKP-VVVINKVDRALLELQVSKED 173 D A++V+ +G QT A +K +V+INK+D + Sbjct: 105 ADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMD------DPTVNW 158 Query: 174 LYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVA 210 + + E + + D+ P G Sbjct: 159 SNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTG 195 >1R5O-A nrPDB Length = 467 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 71/373 (19%), Positives = 141/373 (37%), Gaps = 58/373 (15%) Query: 5 TVDQ--MRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAG 52 VDQ ++ + K N+ I HVD GKSTL +++ G++ A +AG Sbjct: 29 EVDQELLKDMYGKE--HVNIVFIGHVDAGKSTLGGNILFLTGMVDKRTMEKIEREAKEAG 86 Query: 53 EARF-----TDTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPG 107 + + D+ +E+E+G T++ +E +L+D+PG Sbjct: 87 KESWYLSWALDSTSEEREKGKTVEVGRAYFETE----------------HRRFSLLDAPG 130 Query: 108 HVDFSSEVTAALRVTDGALVVVDTIEG-VCV------QTETVLRQALGERIKP-VVVINK 159 H + + + D ++V+ G QT A + I VVVINK Sbjct: 131 HKGYVTNMINGASQADIGVLVISARRGEFEAGFERGGQTREHAVLARTQGINHLVVVINK 190 Query: 160 VDRALLELQVSKEDLYQTFARTVESVNVIVSTY-ADEVLGDVQVYPARGTVAFGSGLHGW 218 +D + S + + + V+ +++ + DV+ P Sbjct: 191 MD------EPSVQWSEERYKECVDKLSMFLRRVAGYNSKTDVKYMPVSAYTGQNVKDRVD 244 Query: 219 AFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNM--- 275 + + ++ +D ++R F P K+ + T EGK + Sbjct: 245 SSVCPWYQGPSLLEY-LDSMTHLERKVNAPFIMPIASKYKDLGTILEGKIEAGSIKKNSN 303 Query: 276 FILDPIFRLFT--AIMNFKKDEIPVLL--EKLEIVLKGDEKDLEGKALLKVVMRKFLPAA 331 ++ PI + AI + +EI + +++ + ++GD+ D++ +L Sbjct: 304 VLVMPINQTLEVTAIYDEADEEISSSICGDQVRLRVRGDDSDVQTGYVLTSTKNPVHATT 363 Query: 332 DALLEMIVLHLPS 344 + ++ +L LPS Sbjct: 364 RFIAQIAILELPS 376 >5LZT-jj nrPDB Length = 637 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 71/218 (32%), Gaps = 45/218 (20%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEAR---------------FTDTR 60 N+ I HVD GKST+ ++ G++ + DT Sbjct: 209 KKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTN 268 Query: 61 KDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALR 120 ++E+++G T++ +E ++D+PGH F + Sbjct: 269 QEERDKGKTVEVGRAYFETE----------------KKHFTILDAPGHKSFVPNMIGGAS 312 Query: 121 VTDGALVVVDTIEG-VCV------QTETVLRQALGERIKP-VVVINKVDRALLELQVSKE 172 D A++V+ +G QT A +K +V+INK+D + Sbjct: 313 QADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMD------DPTVN 366 Query: 173 DLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVA 210 + + E + + D+ P G Sbjct: 367 WSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTG 404 >1ZUN-B nrPDB Length = 434 Score = 106 bits (263), Expect = 5e-23, Method: Composition-based stats. Identities = 47/264 (17%), Positives = 85/264 (32%), Gaps = 41/264 (15%) Query: 14 DKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGII----------SAAKAGE-------ARF 56 ++ +R +VD GKSTL L+ + +I + K+G A Sbjct: 20 ERKEMLR-FLTCGNVDDGKSTLIGRLLHDSKMIYEDHLEAITRDSKKSGTTGDDVDLALL 78 Query: 57 TDTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVT 116 D + E+E+GITI + + D+PGH ++ + Sbjct: 79 VDGLQAEREQGITIDVA----------------YRYFSTAKRKFIIADTPGHEQYTRNMA 122 Query: 117 AALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVV-INKVDRALLELQVSKEDLY 175 D A+++VD GV QT A IK +VV INK+D + + E + Sbjct: 123 TGASTCDLAIILVDARYGVQTQTRRHSYIASLLGIKHIVVAINKMDLNGFD-ERVFESIK 181 Query: 176 QTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGV 235 + + E + + + V + +G + + Sbjct: 182 ADYLKFAEGI-----AFKPTTMAFVPMSALKGDNVVNKSERSPWYAGQSLMEILETVEIA 236 Query: 236 DKAKMMDRLWGDSFFNPKTKKWTN 259 D + + N + Sbjct: 237 SDRNYTDLRFPVQYVNRPNLNFRG 260 >3P27-A nrPDB Length = 483 Score = 103 bits (255), Expect = 4e-22, Method: Composition-based stats. Identities = 43/230 (18%), Positives = 81/230 (35%), Gaps = 54/230 (23%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE---------------ARFTDTRKDEQE 65 + V+ HVD GKSTL L+ I++ ++ + A D +E+E Sbjct: 35 SFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKSSFKFAWIMDQTNEERE 94 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RG+T+ + ++ ++D+PGH DF + D A Sbjct: 95 RGVTVSICTSHFSTHRAN----------------FTIVDAPGHRDFVPNAIMGISQADMA 138 Query: 126 LVVVDTI----------EGVCVQTETVLRQALGERI-KPVVVINKVDRALLELQVSKEDL 174 ++ VD +G QT+ + A I ++ +NK+D + Sbjct: 139 ILCVDCSTNAFESGFDLDG---QTKEHMLLASSLGIHNLIIAMNKMDNVD-----WSQQR 190 Query: 175 YQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQ 224 ++ + V + + D ++ P G G + +RQ Sbjct: 191 FEEIKSKLLPYLVDIGFFED----NINWVPISGFSGEGVYKIEYTDEVRQ 236 >3IZQ-1 nrPDB Length = 611 Score = 103 bits (255), Expect = 4e-22, Method: Composition-based stats. Identities = 43/230 (18%), Positives = 81/230 (35%), Gaps = 54/230 (23%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGE---------------ARFTDTRKDEQE 65 + V+ HVD GKSTL L+ I++ ++ + A D +E+E Sbjct: 169 SFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKSSFKFAWIMDQTNEERE 228 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 RG+T+ + ++ ++D+PGH DF + D A Sbjct: 229 RGVTVSICTSHFSTHRAN----------------FTIVDAPGHRDFVPNAIMGISQADMA 272 Query: 126 LVVVDTI----------EGVCVQTETVLRQALGERI-KPVVVINKVDRALLELQVSKEDL 174 ++ VD +G QT+ + A I ++ +NK+D + Sbjct: 273 ILCVDCSTNAFESGFDLDG---QTKEHMLLASSLGIHNLIIAMNKMDNVD-----WSQQR 324 Query: 175 YQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQ 224 ++ + V + + D ++ P G G + +RQ Sbjct: 325 FEEIKSKLLPYLVDIGFFED----NINWVPISGFSGEGVYKIEYTDEVRQ 370 >6FEC-S nrPDB Length = 422 Score = 99.2 bits (245), Expect = 6e-21, Method: Composition-based stats. Identities = 43/188 (22%), Positives = 67/188 (35%), Gaps = 38/188 (20%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAI----- 75 N+ I HV HGKST+ ++ T K+E ER ITIK Sbjct: 5 NIGTIGHVAHGKSTVVKAI-------------SGVHTVRFKNELERNITIKLGYANAKIY 51 Query: 76 ----------SLYSEMSDEDVKEIKQKTDGNS------FLINLIDSPGHVDFSSEVTAAL 119 Y E G ++ +D PGH + + Sbjct: 52 KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGA 111 Query: 120 RVTDGALVVVDTIEG-VCVQTETVLRQALGERIKPVVVI-NKVDRALLELQVSKEDLYQT 177 V D AL+++ E QT L ++K ++++ NK+D L++ +KE Q Sbjct: 112 AVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKID--LVKESQAKEQYEQI 169 Query: 178 FARTVESV 185 A +V Sbjct: 170 LAFVQGTV 177 >6O81-S nrPDB Length = 472 Score = 98.8 bits (244), Expect = 9e-21, Method: Composition-based stats. Identities = 43/188 (22%), Positives = 67/188 (35%), Gaps = 38/188 (20%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAI----- 75 N+ I HV HGKST+ ++ T K+E ER ITIK Sbjct: 43 NIGTIGHVAHGKSTVVKAI-------------SGVHTVRFKNELERNITIKLGYANAKIY 89 Query: 76 ----------SLYSEMSDEDVKEIKQKTDGNS------FLINLIDSPGHVDFSSEVTAAL 119 Y E G ++ +D PGH + + Sbjct: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGA 149 Query: 120 RVTDGALVVVDTIEG-VCVQTETVLRQALGERIKPVVVI-NKVDRALLELQVSKEDLYQT 177 V D AL+++ E QT L ++K ++++ NK+D L++ +KE Q Sbjct: 150 AVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKID--LVKESQAKEQYEQI 207 Query: 178 FARTVESV 185 A +V Sbjct: 208 LAFVQGTV 215 >3J81-k nrPDB Length = 527 Score = 97.3 bits (240), Expect = 3e-20, Method: Composition-based stats. Identities = 47/241 (19%), Positives = 83/241 (34%), Gaps = 55/241 (22%) Query: 10 RSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGIT 69 ++++ + N+ I HV HGKST+ ++ T KDE ER IT Sbjct: 92 AEIINRQATI-NIGTIGHVAHGKSTVVRAI-------------SGVQTVRFKDELERNIT 137 Query: 70 IKSTAIS----------------LYSEMSDEDVKEIKQKTDGNSFL-----INLIDSPGH 108 IK + S SD+++ Q+ ++ +D PGH Sbjct: 138 IKLGYANAKIYKCQEPTCPEPDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGH 197 Query: 109 VDFSSEVTAALRVTDGALVVVDTIEG-VCVQTETVLRQALGERIKPVVVI-NKVDRALLE 166 S + + V D AL+++ E QT L ++K V+++ NKVD E Sbjct: 198 DILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREE 257 Query: 167 LQVSKED------------------LYQTFARTVESVNVIVSTYADEVLGDVQVYPARGT 208 + + + +++VN + D + P Sbjct: 258 SALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISPRLIV 317 Query: 209 V 209 + Sbjct: 318 I 318 >4CRN-P nrPDB Length = 430 Score = 85.3 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 38/222 (17%), Positives = 71/222 (31%), Gaps = 43/222 (19%) Query: 17 TNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEAR---------------FTDTRK 61 + ++ + HVD GKST+ +L+ G + + DT K Sbjct: 3 KDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQGWYLSWVMDTNK 62 Query: 62 DEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRV 121 +E+ G TI+ +E ++D+PGH + SE+ Sbjct: 63 EERNDGKTIEVGKAYFETE----------------KRRYTILDAPGHKMYVSEMIGGASQ 106 Query: 122 TDGALVVVDTIEG-------VCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDL 174 D ++V+ +G QT A + + +VV + Sbjct: 107 ADVGVLVISARKGEYETGFERGGQTREHALLAKTQGVNKMVV-----VVNKMDDPTVNWS 161 Query: 175 YQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLH 216 + + + V +V+ + + DV P G H Sbjct: 162 KERYDQCVSNVSNFLRAIGYNIKTDVVFMPVSGYSGANLKDH 203 >3E3X-A nrPDB Length = 332 Score = 56.8 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 48/142 (33%), Gaps = 6/142 (4%) Query: 696 DAIHRGGGQIIPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVV 755 + + R G ++ + D ++ EP V I E+ GGI + ++G++ Sbjct: 98 ENMRREGFELAVSRPEVI---IKEEDGQLMEPFETVTIDVMEEHQGGIMENIGLRKGELK 154 Query: 756 SEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKA 815 + + +P GF E T G FDH+ + + Sbjct: 155 DMAPDGKGRV-RMDFIMPSRGLIGFQTEFMTLTSGSGLLYHTFDHYG--PHKGGNIGQRV 211 Query: 816 GEIVLAARKRHGMKEEVPGWQE 837 +++A + + QE Sbjct: 212 NGVLIANAAGKALTNALFNLQE 233 Score = 37.2 bits (84), Expect = 0.032, Method: Composition-based stats. Identities = 14/36 (38%), Positives = 22/36 (61%), Gaps = 2/36 (5%) Query: 530 VAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRE 565 V+G GELHL I ++++ + G L +S P V +E Sbjct: 85 VSGRGELHLSILIENMRRE--GFELAVSRPEVIIKE 118 >4ZCK-A nrPDB Length = 332 Score = 55.7 bits (132), Expect = 7e-08, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 53/142 (37%), Gaps = 6/142 (4%) Query: 696 DAIHRGGGQIIPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVV 755 + + R G ++ + + F D + QEP V + EQ G + L +++G + Sbjct: 100 ENMRREGFELAVSRPKVI---FREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLK 156 Query: 756 SEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKA 815 + + + +P GF E T G F H+ + P + + Sbjct: 157 NMNPDGKGRV-RLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDV--RPGEVGQRQ 213 Query: 816 GEIVLAARKRHGMKEEVPGWQE 837 ++++ + + + G Q+ Sbjct: 214 NGVLISNGQGKAVAFALFGLQD 235 Score = 43.4 bits (100), Expect = 5e-04, Method: Composition-based stats. Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 6/64 (9%) Query: 506 EGLKRLSKS-DPCVLTYMSESGEH---IVAGTGELHLEICLQDLEHDHAGVPLKISPPVV 561 + L RL+K V + E+ + V+G GELHL + ++++ + G L +S P V Sbjct: 59 QILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRRE--GFELAVSRPKV 116 Query: 562 AYRE 565 +RE Sbjct: 117 IFRE 120 >5DN8-A nrPDB Length = 446 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 28/167 (16%), Positives = 55/167 (32%), Gaps = 42/167 (25%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 +++I + GKSTL + L+ ER I + Sbjct: 181 IAMIGRPNVGKSTLINRLLGE----------------------ERVI---------VYDQ 209 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHV------DFSS--EVTAALRVT---DGALVVVD 130 I N LID+ G D+ + +L+ D + ++D Sbjct: 210 PGTTRDSIYIPFARNDENYTLIDTAGIRRRAKIQDYVEKFSMIKSLQAMHAADVVIFLLD 269 Query: 131 TIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQT 177 +GV Q +L + + + ++ +NK D +E + + + Sbjct: 270 ARQGVTEQDLRLLNRIVEAGVSLIIAVNKWDGLNIEERDNVRNAIDR 316 Score = 46.1 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 30/142 (21%), Positives = 52/142 (36%), Gaps = 22/142 (15%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ + GKSTL + L + + A G R D + E TI S + L Sbjct: 8 IAIVGRPNVGKSTLFNYLTKSRAALVADVPGVTR--DRQYGE----TTIDSQRLLLVDTG 61 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 D + + + + ID +D L +VD G+ E Sbjct: 62 GLVDTENKEVAPLAETQVEQAID----------------ESDCILFLVDAKAGLVPADEI 105 Query: 142 VLRQALGERIKPVVVINKVDRA 163 + + + K + +NK DRA Sbjct: 106 IAERLRKKGKKIFLAVNKADRA 127 >3R9W-A nrPDB Length = 307 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 31/155 (20%), Positives = 55/155 (35%), Gaps = 43/155 (27%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ + GKSTL ++L+ I + KAG R Sbjct: 12 VAIVGKPNVGKSTLLNNLLGTKVSIISPKAGTTR-------------------------- 45 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSP-----------GHVDFSSEVTAALRVTDGALVVVD 130 ++ + K N I +D+P GH +L D L ++D Sbjct: 46 ----MRVLGVKNIPNEAQIIFLDTPGIYEPKKSDVLGH-SMVEIAKQSLEEADVILFMID 100 Query: 131 TIEGVCVQTETVLRQALGE-RIKPVVVINKVDRAL 164 EG + E + + + +VVINK+D+ Sbjct: 101 ATEGWRPRDEEIYQNFIKPLNKPVIVVINKIDKIG 135 >5MVF-A nrPDB Length = 523 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 64/426 (15%), Positives = 129/426 (30%), Gaps = 28/426 (6%) Query: 22 MSVIAHVDHGKSTLTDSLVQR--AGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYS 79 + ++ GK+T L+++ G+ + F E E G T + + Sbjct: 46 ILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETE-GSTPGNALVVDPK 104 Query: 80 EMSDEDVKE---------IKQKTDGNSFLINLIDSPGHVDFSSEVT-AA----------L 119 + + + Q + I++IDSPG + + Sbjct: 105 KPFRKLSRFGNAFLNRFMCSQLPNQVLKSISIIDSPGILSGEKQRISRGYDFCQVLQWFA 164 Query: 120 RVTDGALVVVDTIE-GVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTF 178 D +++ D + + + ++ G+ K VV+NK D+ + + Sbjct: 165 ERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWS 224 Query: 179 ARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKA 238 V + ++ Y + F + I+ + A + D Sbjct: 225 LGKVINTPEVLRVYIGSFWAQ-PLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLI 283 Query: 239 KMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPV 298 K ++ KK E K E + + + + I E+ Sbjct: 284 KRARLAKVHAYIISYLKKEMPNMFGKENKKRELIYRLPEIYVQLQREYQISAGDFPEVKA 343 Query: 299 LLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIV-LHLPSPVT-AQAYRAEQL 356 + E+LE L+ K L++ V +L+ +I + P Q + Sbjct: 344 MQEQLENYDFTKFHSLKPK-LIEAVDNMLTNKISSLMGLISQEEMNMPTQMVQGGAFDGT 402 Query: 357 YEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGP 416 EGP + K + + ++ K V +G + V + P Sbjct: 403 TEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLP 462 Query: 417 NYVPGK 422 N V GK Sbjct: 463 NSVLGK 468 >5G06-P nrPDB Length = 747 Score = 48.0 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 70/219 (31%), Gaps = 53/219 (24%) Query: 25 IAHVDHGKSTLTDSLVQRAGIISAAKAGEARF----------------TDTRKDEQERGI 68 + + GKSTL L+ IS + E + D K E+E G Sbjct: 273 LGDTNAGKSTLLGHLLYDLNEISMSSMRELQKKSSNLDPSSSNSFKVILDNTKTERENGF 332 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVD-FSSEVTAALRVTD--GA 125 ++ + V +++ S + LID+PG + F+ E ++ D Sbjct: 333 SM------------FKKVIQVENDLLPPSSTLTLIDTPGSIKYFNKETLNSILTFDPEVY 380 Query: 126 LVVVDTI--------EGVCVQTETVLRQALGERIK------PVVVINKVDRALLELQVSK 171 ++V+D +G Q +L+ ++++NK D + Sbjct: 381 VLVIDCNYDSWEKSLDGPNNQIYEILKVISYLNKNSACKKHLIILLNKADLISWDK---- 436 Query: 172 EDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVA 210 +N ++ + Q P G + Sbjct: 437 ----HRLEMIQSELNYVLKENFQWTDAEFQFIPCSGLLG 471 >4ZKD-A nrPDB Length = 499 Score = 48.0 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 70/219 (31%), Gaps = 53/219 (24%) Query: 25 IAHVDHGKSTLTDSLVQRAGIISAAKAGEARF----------------TDTRKDEQERGI 68 + + GKSTL L+ IS + E + D K E+E G Sbjct: 25 LGDTNAGKSTLLGHLLYDLNEISMSSMRELQKKSSNLDPSSSNSFKVILDNTKTERENGF 84 Query: 69 TIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVD-FSSEVTAALRVTD--GA 125 ++ + V +++ S + LID+PG + F+ E ++ D Sbjct: 85 SM------------FKKVIQVENDLLPPSSTLTLIDTPGSIKYFNKETLNSILTFDPEVY 132 Query: 126 LVVVDTI--------EGVCVQTETVLRQALGERIK------PVVVINKVDRALLELQVSK 171 ++V+D +G Q +L+ ++++NK D + Sbjct: 133 VLVIDCNYDSWEKSLDGPNNQIYEILKVISYLNKNSACKKHLIILLNKADLISWDK---- 188 Query: 172 EDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVA 210 +N ++ + Q P G + Sbjct: 189 ----HRLEMIQSELNYVLKENFQWTDAEFQFIPCSGLLG 223 >2QTH-A nrPDB Length = 364 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 28/171 (16%), Positives = 63/171 (36%), Gaps = 52/171 (30%) Query: 14 DKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKST 73 +K N+ ++ ++ + + GK++L +SL G+T K Sbjct: 174 NKRNNIPSIGIVGYTNSGKTSLFNSLT--------------------------GLTQKV- 206 Query: 74 AISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEV-----------TAALRVT 122 + + N+ I L+D+ G F + + + + Sbjct: 207 -----DTKLFTTMSPKRYAIPINNRKIMLVDTVG---FIRGIPPQIVDAFFVTLSEAKYS 258 Query: 123 DGALVVVDTI--EGVCVQTE----TVLRQALGERIKPVVVINKVDRALLEL 167 D ++V+D+ E + ++T +LR+ +V +NK+D+ +L Sbjct: 259 DALILVIDSTFSENLLIETLQSSFEILREIGVSGKPILVTLNKIDKINGDL 309 >4IXM-A nrPDB Length = 318 Score = 46.8 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 34/191 (17%), Positives = 64/191 (33%), Gaps = 22/191 (11%) Query: 24 VIAHVDHGKSTLTDSLVQRAG----IISAAKAGEARFTDTRKDEQERGITIKSTAISLYS 79 + + GK+TL ++ + + GE D ++ I + S Sbjct: 9 LTGFLGAGKTTLLRHILNEQHGYKIAVIENEFGEVSVDDQLIGDRATQIKTLTNGCICCS 68 Query: 80 EMSDEDVKEIKQKTDGNSFLINL----IDSPGHVD--------FSSEVTAALRVTDGALV 127 ++ + + + + I I+ G D FS EV + DG + Sbjct: 69 RSNELEDALLDLLDNLDKGNIQFDRLVIECTGMADPGPIIQTFFSHEVLCQRYLLDGVIA 128 Query: 128 VVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNV 187 +VD + + + Q+ ++ + K D A E L++ AR V Sbjct: 129 LVDAVHADEQMNQFTIAQSQVGYADRIL-LTKTDVAG-----EAEKLHERLARINARAPV 182 Query: 188 IVSTYADEVLG 198 T+ D LG Sbjct: 183 YTVTHGDIDLG 193 >3IEU-A nrPDB Length = 301 Score = 45.7 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 31/173 (17%), Positives = 61/173 (35%), Gaps = 44/173 (25%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ + GKSTL + L+ + I++ KA + R + I + Sbjct: 11 IAIVGRPNVGKSTLLNKLLGQKISITSRKAQTT---------RHRIVGIHT--------- 52 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPG-H----VDFSSEVTAALRVTDGAL-VVVDTIEGV 135 ++ +D+PG H + + A + G + +V+ +EG Sbjct: 53 -------------EGAYQAIYVDTPGLHMEEKRAINRLMNKAASSSIGDVELVIFVVEGT 99 Query: 136 C--VQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVN 186 E VL + + ++ +NKVD K DL +N Sbjct: 100 RWTPDDEMVLNKLREGKAPVILAVNKVDNV-----QEKADLLPHLQFLASQMN 147 >3J8G-X nrPDB Length = 490 Score = 45.3 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 28/157 (17%), Positives = 60/157 (38%), Gaps = 24/157 (15%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQ--ERGITIKSTAISLYS 79 ++++ + GKSTLT+ ++ ++ G R + E+ + I + + Sbjct: 205 LAIVGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERDGREYVLIDTAGVRKRG 264 Query: 80 EMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQT 139 +++D K KT N++ ++V+D EG+ Q Sbjct: 265 KITDAVEKFSVIKTLQAIEDANVV----------------------MLVIDAREGISDQD 302 Query: 140 ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 ++L L V+V+NK D E++ ++ Sbjct: 303 LSLLGFILNSGRSLVIVVNKWDGLSQEVKEQVKETLD 339 Score = 42.6 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 33/160 (20%), Positives = 52/160 (32%), Gaps = 35/160 (21%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ + GKSTL + L + +A D ++R Y Sbjct: 5 VALVGRPNVGKSTLFNRLTRT---------RDALVADFPGLTRDRK----------YGRA 45 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTA-----ALRVTDGALVVVDTIEGVC 136 E + I T G ID G D A A+ D L +VD G+ Sbjct: 46 EIEGREFICIDTGG-------ID--GTEDGVETRMAEQSLLAIEEADVVLFMVDARAGLM 96 Query: 137 VQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 E + + +V NK D L+ + D Y Sbjct: 97 PADEAIAKHLRSREKPTFLVANKTD--GLDPDQAVVDFYS 134 >1WF3-A nrPDB Length = 301 Score = 43.4 bits (100), Expect = 5e-04, Method: Composition-based stats. Identities = 57/331 (17%), Positives = 107/331 (32%), Gaps = 61/331 (18%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ + GKSTL ++L+ K ++ RGI Sbjct: 10 VAIVGKPNVGKSTLLNNLL-------GVKVAPISPRPQTTRKRLRGI------------- 49 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPG-H------VDFSS-EVTAALRVTDGALVVVDTIE 133 I +D+PG H +F EV AL + + VVD Sbjct: 50 -----------LTEGRRQIVFVDTPGLHKPMDALGEFMDQEVYEALADVNAVVWVVDLRH 98 Query: 134 GVCVQTETVLRQALGE--RIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 + E V R ++ ++V NK+D A E+ + + + + + Sbjct: 99 PPTPEDELVARALKPLVGKVPILLVGNKLDAA-----KYPEEAMKAYHELLPEAEPRMLS 153 Query: 192 YADEVLGDVQVYPARGTVAFGSGLH--GWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSF 249 DE + G + +A + + F A+ + + M RLW + Sbjct: 154 ALDERQVAELKADLLALMPEGPFFYPEDYAKSDQTFGEWVAEIL---REEAMKRLWHEVP 210 Query: 250 FNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKG 309 + TK + + E L +++ P + + + E + K Sbjct: 211 YAVATK--VEEVAERENGVLYIKAILYVERPSQKAI-----VIGEGGRKIKEIGQATRKQ 263 Query: 310 DEKDLEGKALLKV---VMRKFLPAADALLEM 337 E L K L + V + +AL E+ Sbjct: 264 LEALLGKKVYLDLEVKVYPDWRKDPEALREL 294 >5LAD-A nrPDB Length = 404 Score = 42.6 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 27/140 (19%), Positives = 53/140 (37%), Gaps = 11/140 (7%) Query: 68 ITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSE----VTAALRV-- 121 + + +S Y+ + + V + + + L+D+PG D V A RV Sbjct: 30 VGQNVSIVSEYAGTTTDPVYKSMELYPVGP--VTLVDTPGLDDVGELGRLRVEKARRVFY 87 Query: 122 -TDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR 180 D ++V D+ + V+ I VVV+NK+D + + K + Sbjct: 88 RADCGILVTDSE--PTPYEDDVVNLFKEMEIPFVVVVNKIDVLGEKAEELKGLYESRYEA 145 Query: 181 TVESVNVIVSTYADEVLGDV 200 V V+ + D++ + Sbjct: 146 KVLLVSALQKKGFDDIGKTI 165 >4HI0-E nrPDB Length = 199 Score = 42.6 bits (98), Expect = 8e-04, Method: Composition-based stats. Identities = 34/172 (19%), Positives = 63/172 (36%), Gaps = 32/172 (18%) Query: 22 MSVIAHVDHGKSTLTDSLV------QRAGIISA---AKAGEARFTDTRKDEQERGITIKS 72 + V V GK+ L ++L +I+ K +ER I +++ Sbjct: 4 IGVCGPVGSGKTALIEALTRHMSKDYDMAVITNDIYTKEDAEFMCKNSVMPRERIIGVET 63 Query: 73 T---AISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPG---HVDFSSEVTAALRVTDGAL 126 ++ + S + + + LI+S G F+ E + D + Sbjct: 64 GGCPHTAIREDASMNLEAVEEMHGRFPNLELLLIESGGDNLSATFNPE------LADFTI 117 Query: 127 VVVDTIEGVCVQTETVLRQALGERIKP--VVVINKVDRA---LLELQVSKED 173 V+D EG + + G I ++VINK+D A +L+V + D Sbjct: 118 FVIDVAEG------DKIPRKGGPGITRSDLLVINKIDLAPYVGADLKVMERD 163 >1MKY-A nrPDB Length = 439 Score = 42.2 bits (97), Expect = 9e-04, Method: Composition-based stats. Identities = 26/165 (15%), Positives = 62/165 (37%), Gaps = 20/165 (12%) Query: 15 KVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTA 74 ++T+ ++++ + GKSTL ++++ + + + G R D DE + I Sbjct: 176 EITDAIKVAIVGRPNVGKSTLFNAILNKERALVSPIPGTTR--DPVDDE----VFIDGRK 229 Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEG 134 ++ +T ++D ++ D ++V+D +G Sbjct: 230 YVFVDTAGLRRKSRVEPRTVEKYSNYRVVD-------------SIEKADVVVIVLDATQG 276 Query: 135 VCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFA 179 + Q + + VVV NK D ++ + ++ + F Sbjct: 277 ITRQDQRMAGLMERRGRASVVVFNKWD-LVVHREKRYDEFTKLFR 320 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 31/157 (19%), Positives = 56/157 (35%), Gaps = 24/157 (15%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 + ++ + GKSTL + LV++ I E E G+T ++ Sbjct: 3 TVLIVGRPNVGKSTLFNKLVKKKKAIV---------------EDEEGVTRDPVQDTVEWY 47 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAAL-RVTDGALVVVDTIEGVCVQT 139 + + D +I+ EVT + R D L VVD G+ + Sbjct: 48 GKTFKLVDTCGVFDNPQDIISQK--------MKEVTLNMIREADLVLFVVDGKRGITKED 99 Query: 140 ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 E++ + ++V NK + + K +LY Sbjct: 100 ESLADFLRKSTVDTILVANKAENLREFEREVKPELYS 136 >3GEH-A nrPDB Length = 462 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 57/175 (32%), Gaps = 30/175 (17%) Query: 2 VAFTVDQMRSLMDKVTNVRN---MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTD 58 +A + Q+ + DK +R ++++ + GKS+L ++ +D Sbjct: 204 IAAEISQLLATKDKGELLRTGLKVAIVGRPNVGKSSLLNA---------------WSQSD 248 Query: 59 TRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTA- 117 G T L V + + + + + E + Sbjct: 249 RAIVTDLPGTTRDVVESQLVVGGIPVQVLDTAGIRETSDQVEKI---------GVERSRQ 299 Query: 118 ALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKE 172 A D L+ +D G + + Q ++V+NK+D +L S E Sbjct: 300 AANTADLVLLTIDAATGWTTGDQEIYEQVKHR--PLILVMNKIDLVEKQLITSLE 352 >2WIC-A nrPDB Length = 267 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 35/176 (19%), Positives = 57/176 (32%), Gaps = 30/176 (17%) Query: 21 NMSVIAHVDHGKSTLTDSLV---QRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISL 77 + +I + + GK+TL + L QR G + E++ GI + Sbjct: 5 TVGLIGNPNSGKTTLFNQLTGARQRVGNWAGVTV-----------ERKEGIFATTDHQVT 53 Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 ++ I H S + D + VVD Sbjct: 54 LVDLPGTYSLTTISSQTSLDEQIAC-----HYILSGD-------ADMLINVVDASN--LE 99 Query: 138 QTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYA 193 + + Q L I VV +N +D + E Q + D+ AR V +VST Sbjct: 100 RNLYLTLQLLELGIPCVVALNMLD--IAEKQQVRIDIDALAARLGCPVIPLVSTRG 153 >5KH0-A nrPDB Length = 396 Score = 39.9 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 34/221 (15%), Positives = 67/221 (30%), Gaps = 32/221 (14%) Query: 40 VQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFL 99 + I G++ F + QE I + ++ + Sbjct: 8 RKYIAITGRRNVGKSSFMNALIG-QEVSIVSNVAGTTTDPVFKSMELSPVGP-------- 58 Query: 100 INLIDSPGHVDF-------SSEVTAALRVTDGALVVVDTIEG-VCVQTETVLRQALGERI 151 I LID+PG D + +L D +++VD I G Q + ++ I Sbjct: 59 ITLIDTPGLDDVGELGIKRIKKAKKSLYRADCGILIVDDIPGNFEEQIIKLFKELE---I 115 Query: 152 KPVVVINKVDRALLELQVSKEDLYQT------------FARTVESVNVIVSTYADEVLGD 199 + INK+D E + Y F + +++N I+ + Sbjct: 116 PYFIAINKIDTIDHENIEKEYKKYNVPILKVSALKKIGFEKIGKTINSILPKDDEIPYLS 175 Query: 200 VQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKM 240 + + G +A + G+D+ + Sbjct: 176 DLIDGGDLVILVVPIDLGAPKGRLIMPQVHAIREGLDREAL 216 >5L94-A nrPDB Length = 410 Score = 39.9 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 40/326 (12%), Positives = 98/326 (30%), Gaps = 27/326 (8%) Query: 228 RYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTA 287 R + + W + N +W + + +++F D + + Sbjct: 11 RQVNTIQTKEERFNPFSWYEEMRNTAPVQWDEE---------RQVWDVFHYDGVKEVLEQ 61 Query: 288 ----------IMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEM 337 N ++ + L ++ + + L KA M+ + P + Sbjct: 62 KNIFSSDRRPPQNQRQTALGTSLINIDPPKHAEMRALVNKAFTPKAMKAWEPKIARITNE 121 Query: 338 IVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAF 397 ++ + Y P I + + + +V Sbjct: 122 LLQEVEHLEDIDIVE-HLSYPLPVMVIADILGVPIEDQRQFKDWSDIIVAGPSNNERETL 180 Query: 398 GRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGN-IIGL 456 ++ +K+ ++ + K+ I ++ + D+ G I+ L Sbjct: 181 EKLQQEKMKANDELETYFYRIIEEKRTRPGDDIISVLLQAKEEGKQLTDEEIVGFSILLL 240 Query: 457 VGIDQF---LLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSK 513 + ++ L+ E + + +K ++ +E P V+ L R+ K Sbjct: 241 IAGNETTTNLISNTIYCLMEDKASFERLKREKE-LLPSGIEEVLRYRSP--VQALHRIVK 297 Query: 514 SDPCVLTYMSESGEHIVAGTGELHLE 539 D + ++GEH+V G H + Sbjct: 298 EDVTLAGKKLKAGEHVVPWMGSAHRD 323 >2E87-A nrPDB Length = 357 Score = 39.5 bits (90), Expect = 0.007, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 56/162 (34%), Gaps = 46/162 (28%) Query: 19 VRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLY 78 + + + H + GKSTL +L I++ RGI + Sbjct: 167 IPTVVIAGHPNVGKSTLLKALTTAKPEIASYPFTT------------RGINV-------- 206 Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVD--------FSSEVTAALRVT-DGALVVV 129 + + F +ID+PG +D + ALR + + + Sbjct: 207 ------------GQFEDGYFRYQIIDTPGLLDRPISERNEIEKQAILALRYLGNLIIYIF 254 Query: 130 DTIE--GVCVQTETVL---RQALGERIKPVVVINKVDRALLE 166 D E G ++ + L + + +VVINK+D A E Sbjct: 255 DPSEHCGFPLEEQIHLFEEVHGEFKDLPFLVVINKIDVADEE 296 >3PIR-A nrPDB Length = 183 Score = 39.1 bits (89), Expect = 0.008, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 45/110 (40%), Gaps = 11/110 (10%) Query: 77 LYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVC 136 + + ED + D +++++D+ G +FS+ +R DG L+V + Sbjct: 45 PEYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTD--K 102 Query: 137 VQTETV-------LRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFA 179 E V LR E ++V NKVD L+ L+ D + A Sbjct: 103 ASFEHVDRFHQLILRVKDRESFPMILVANKVD--LMHLRKVTRDQGKEMA 150 >4DCU-A nrPDB Length = 456 Score = 39.1 bits (89), Expect = 0.009, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 44/110 (40%), Gaps = 10/110 (9%) Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPG----HVDFSSEVTAALRVT----DGAL 126 IS+ + I + ++ NLID+ G F +++ + D + Sbjct: 48 ISIVEDTPGVTRDRIYSSAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVII 107 Query: 127 VVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 +V+ EGV E V + + V+ +NK+D E++ + D Y Sbjct: 108 FMVNGREGVTAADEEVAKILYRTKKPVVLAVNKLDNT--EMRANIYDFYS 155 Score = 38.7 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 34/171 (19%), Positives = 64/171 (37%), Gaps = 29/171 (16%) Query: 17 TNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAIS 76 V +I + GKS+L ++++ +I + AG R + ++ Sbjct: 193 EEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDA------------VDTSFTY 240 Query: 77 LYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTD---GALVVVDTIE 133 E D +++K G + +S V AL+ D VV+D E Sbjct: 241 NQQEFVIVDTAGMRKK--GKVYETT-------EKYS--VLRALKAIDRSEVVAVVLDGEE 289 Query: 134 GVCVQTETVLRQALGERIKPVVVINK---VDRALLELQVSKEDLYQTFART 181 G+ Q + + A V+V+NK VD+ ++ +E++ F Sbjct: 290 GIIEQDKRIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFL 340 >5X4B-A nrPDB Length = 162 Score = 38.7 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 39/99 (39%), Gaps = 8/99 (8%) Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPG----HVDFSSEVTAALRVT----DGAL 126 IS+ + I + ++ NLID+ G F +++ + D + Sbjct: 27 ISIVEDTPGVTRDRIYSSAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVII 86 Query: 127 VVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALL 165 +V+ EGV E V + + V+ +NK+D + Sbjct: 87 FMVNGREGVTAADEEVAKILYRTKKPVVLAVNKLDNTEM 125 >2CXX-A nrPDB Length = 190 Score = 38.7 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 26/181 (14%), Positives = 53/181 (29%), Gaps = 33/181 (18%) Query: 31 GKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSDEDVKEIK 90 GKSTL L + + + G+T K I + + Sbjct: 13 GKSTLIYRLTGK----------------KVRRGKRPGVTRKIIEIEWKNHKIIDMPGFGF 56 Query: 91 QKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVC-----------VQT 139 + D H F + + D A++VVD Sbjct: 57 MMGLPKEVQERIKDEIVH--FIED---NAKNIDVAVLVVDGKAAPEIIKRWEKRGEIPID 111 Query: 140 ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGD 199 + I +V +NK+D+ + +Q L + F + ++ + + + + Sbjct: 112 VEFYQFLRELDIPTIVAVNKLDK-IKNVQEVINFLAEKFEVPLSEIDKVFIPISAKFGDN 170 Query: 200 V 200 + Sbjct: 171 I 171 >3A1U-A nrPDB Length = 258 Score = 38.7 bits (88), Expect = 0.011, Method: Composition-based stats. Identities = 33/229 (14%), Positives = 69/229 (30%), Gaps = 6/229 (2%) Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDF----SSEVTAALRVTDG-AL 126 + + V++ + + INLID PG E A + G A Sbjct: 26 TGTKQYVANWPGVTVEKKEGVFTYKGYTINLIDLPGTYSLGYSSIDEKIARDYLLKGDAD 85 Query: 127 VVVDTIEGVCV-QTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESV 185 +V+ + V Q+ +L + L K ++ + +D A Q Sbjct: 86 LVILVADSVNPEQSLYLLLEILEMEKKVILAMTAIDEAKKTGMKIDRYELQKHLGIPVVF 145 Query: 186 NVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLW 245 V+ E L + V A+ + + + + K ++ R + Sbjct: 146 TSSVTGEGLEELKEKIVEYAQKNTILHRMILDYGEKVESEIKKVENFLRDKKLRINPRYF 205 Query: 246 GDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKD 294 + + + ++ + E + L R + N K+ Sbjct: 206 ALKYLSGDPEFYSEGVKLGLPELSEEERIGYRLLIAKRKREYVENVVKE 254 >5ZZM-A nrPDB Length = 426 Score = 38.4 bits (87), Expect = 0.014, Method: Composition-based stats. Identities = 32/169 (18%), Positives = 56/169 (33%), Gaps = 25/169 (14%) Query: 16 VTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITI---KS 72 +V +S++ + + GKSTL + + + + T R D + G T+ Sbjct: 194 KADVPTVSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVGETVLADTV 253 Query: 73 TAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTI 132 I K Q+T + L+++ID+ D V Sbjct: 254 GFIRHLPHDLVAAFKATLQETRQATLLLHVIDA----------------AD-----VRVQ 292 Query: 133 EGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFART 181 E + TVL + I ++V+NK+D D R Sbjct: 293 ENIEA-VNTVLEEIDAHEIPTLLVMNKIDMLEDFEPRIDRDEENKPNRV 340 >4V0N-A nrPDB Length = 169 Score = 37.6 bits (85), Expect = 0.024, Method: Composition-based stats. Identities = 24/141 (17%), Positives = 45/141 (31%), Gaps = 28/141 (19%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 N+ V+ + GK+T+ + L R + D E E+G T Sbjct: 8 NVLVVGLDNSGKTTIIERLKPRPRQAAEVAPTVGFTVD----EVEKGP---LTFTVFDMS 60 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTE 140 + +Q ++ ++DS D +VV E E Sbjct: 61 GAGRYRTLWEQYYREADAVVFVVDS----------------ADKLRMVVARDE-----ME 99 Query: 141 TVLRQALGERIKPVVVINKVD 161 +L+ + ++ + NK D Sbjct: 100 HMLKHSNMRKVPILYFANKKD 120 >2QPT-A nrPDB Length = 550 Score = 37.2 bits (84), Expect = 0.028, Method: Composition-based stats. Identities = 63/434 (14%), Positives = 128/434 (29%), Gaps = 39/434 (8%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTD----TRKDEQERGITIKSTAISL 77 + V GK++ L+++ + ++ G TD E E T+ A+ + Sbjct: 68 VLVAGQYSTGKTSFIQYLLEQ--EVPGSRVGPEPTTDCFVAVMHGETEG--TVPGNALVV 123 Query: 78 YSEMSDEDVKEIKQKTDGNS----------FLINLIDSPG-----------HVDFSSEVT 116 E + I++ID+PG DF + + Sbjct: 124 DPEKPFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLR 183 Query: 117 AALRVTDGALVVVDTIEGVCVQTE--TVLRQALGERIKPVVVINKVDRALLELQVSKEDL 174 D +++ D + + + E + G K VV+NK D + + Sbjct: 184 WFAERVDLIILLFDAHK-LEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGA 242 Query: 175 YQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFG 234 V ++ Y + P + F I+ A + Sbjct: 243 LMWALGKVVGTPEVLRVYIGSFWSQPLLVPDNRRL-FELEEQDLFRDIQGLPRHAALRKL 301 Query: 235 VDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKD 294 D K + ++ KK E K + + ++ +L I Sbjct: 302 NDLVKRARLVRVHAYIISYLKKEMPTVFGKENKKKQLILKLPVIFAKIQLEHHISPGDFP 361 Query: 295 EIPVLLEKLEIVLKGDEKDLEGK---ALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAY 351 + + E L L+ K AL ++ + L + + + + V A+ Sbjct: 362 DCQKMQELLMAHDFTKFHSLKPKLLEALDDMLAQDIAKLMPLLRQEELESVEAGVAGGAF 421 Query: 352 RAEQLY---EGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSG 408 ++ E D+A + + A+ ++ K +G+ Sbjct: 422 EGTRMGPFVERGPDEAIEDGEEGSEDDAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKT 481 Query: 409 QKVRIQGPNYVPGK 422 V + PN V G+ Sbjct: 482 WMVGTKLPNSVLGR 495 >4R98-A nrPDB Length = 271 Score = 36.8 bits (83), Expect = 0.036, Method: Composition-based stats. Identities = 49/301 (16%), Positives = 93/301 (30%), Gaps = 62/301 (20%) Query: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSE 80 + +I + + GK+TL + L R + G+T Sbjct: 5 TIGLIGNPNSGKTTLFNQLT----------GSRQRVGNWA------GVT----------- 37 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRV--------------TDGAL 126 V+ + + + L+D PG +S ++ D + Sbjct: 38 -----VERKEGQFSTTDHQVTLVDLPG--TYSLTTISSQTSLDEQIACHYILSGDADLLI 90 Query: 127 VVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVN 186 VVD + + Q L I +V +N +D + E Q + ++ AR V Sbjct: 91 NVVDASN--LERNLYLTLQLLELGIPCIVALNMLD--IAEKQNIRIEIDALSARLGCPVI 146 Query: 187 VIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLW- 245 +V+T V +++ R L +A + A AK D + R W Sbjct: 147 PLVATDTKNVQFVLKLAIDRYKANENVELVHYAQPLLNEADSLAKVMPSD-IPLKQRRWL 205 Query: 246 ------GDSFFNPKTKKWTN--KDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIP 297 GD + + + A + + I D ++ AI + + + Sbjct: 206 GLQMLEGDIYSRAYAGEASQHLDAALARLRNEMDDPALHIADARYQCIAAICDVVSNTLT 265 Query: 298 V 298 Sbjct: 266 A 266 >2WSM-A nrPDB Length = 221 Score = 36.8 bits (83), Expect = 0.037, Method: Composition-based stats. Identities = 32/146 (21%), Positives = 55/146 (37%), Gaps = 21/146 (14%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 ++++ + GK+ L + ++R G A E+ R IK+ AIS E Sbjct: 33 VNIMGAIGSGKTLLIERTIERIGNEVKIGAMLGDVVSKADYERVRRFGIKAEAISTGKEC 92 Query: 82 SDEDVKEIKQKTDGNSFLINLID------SPGHVDF-SSEVTAALRVTDGALVVVDTIEG 134 + + + + LI+ P VDF E +V+V EG Sbjct: 93 HLDAHMIYHRLKKFSDCDLLLIENVGNLICP--VDFDLGENYR--------VVMVSVTEG 142 Query: 135 VCVQTETVLRQALGERIKPVVVINKV 160 + V + R+ ++VINKV Sbjct: 143 ----DDVVEKHPEIFRVADLIVINKV 164 >5CM8-B nrPDB Length = 203 Score = 36.8 bits (83), Expect = 0.039, Method: Composition-based stats. Identities = 23/88 (26%), Positives = 36/88 (40%), Gaps = 5/88 (5%) Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQ 138 E + D K DG I+++D+ G D+++ R +G L V + Q Sbjct: 42 YEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITDDESFQ 101 Query: 139 T-----ETVLRQALGERIKPVVVINKVD 161 E +LR E I ++V NK D Sbjct: 102 ATQEFREQILRVKNDESIPFLLVGNKCD 129 >2FN4-A nrPDB Length = 181 Score = 36.4 bits (82), Expect = 0.049, Method: Composition-based stats. Identities = 22/104 (21%), Positives = 40/104 (38%), Gaps = 13/104 (12%) Query: 68 ITIKSTAISLYSE--MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 +TI+ S+ + ED DG ++++D+ G +F + +R G Sbjct: 25 LTIQFIQSYFVSDYDPTIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGF 84 Query: 126 LVVVDTIEGVCVQT--------ETVLRQALGERIKPVVVINKVD 161 L+V + Q+ +LR + V+V NK D Sbjct: 85 LLVFAIND---RQSFNEVGKLFTQILRVKDRDDFPVVLVGNKAD 125 >5ZLU-EE nrPDB Length = 497 Score = 36.4 bits (82), Expect = 0.049, Method: Composition-based stats. Identities = 28/124 (22%), Positives = 45/124 (36%), Gaps = 18/124 (14%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKS--------- 72 + ++ GKS+L L G I A+A RF D Q GI I++ Sbjct: 33 IGLVGDNGAGKSSLLKVL---NGEIVLAEATLQRFGDFAHISQLGGIEIETVEDRAMLSR 89 Query: 73 ---TAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSP-GHVDF--SSEVTAALRVTDGAL 126 + + + E+ + L D P H+D + L+ DGAL Sbjct: 90 LGVSNVQNDTMSGGEETRAKIAAAFSQQVHGILADEPTSHLDLNGIDLLIGQLKAFDGAL 149 Query: 127 VVVD 130 +V+ Sbjct: 150 LVIS 153 >5WDR-A nrPDB Length = 171 Score = 35.7 bits (80), Expect = 0.098, Method: Composition-based stats. Identities = 22/104 (21%), Positives = 42/104 (40%), Gaps = 13/104 (12%) Query: 68 ITIKS--TAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 +TI+ + + ED D + L++++D+ G D+S+ +R +G Sbjct: 23 LTIQLIQQHFVTEYDPTIEDSYRKHVSIDDEACLLDILDTAGQEDYSAMRDQYMRTGEGF 82 Query: 126 LVVVDTIEGVCVQT--------ETVLRQALGERIKPVVVINKVD 161 L V Q+ E +LR + + ++V NK D Sbjct: 83 LCVYSIDS---QQSLDEIHSFREQILRVKDQDEVPMILVGNKCD 123 >1XZP-A nrPDB Length = 482 Score = 35.3 bits (79), Expect = 0.10, Method: Composition-based stats. Identities = 31/163 (19%), Positives = 57/163 (34%), Gaps = 26/163 (15%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDE-QERGITIKSTAISLYSE 80 M ++ + GKSTL + L+ I G R D +E RGI + + Sbjct: 246 MVIVGKPNVGKSTLLNRLLNEDRAIVTDIPGTTR--DVISEEIVIRGILFRIVDTAGVRS 303 Query: 81 MSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTE 140 +++ V+ + + + D L V+D + + Sbjct: 304 ETNDLVERLGIERTLQE---------------------IEKADIVLFVLDASSPLDEEDR 342 Query: 141 TVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVE 183 +L + +R +VVINKVD + ++ T V+ Sbjct: 343 KILERIKNKRY--LVVINKVDVVEKINEEEIKNKLGTDRHMVK 383 >1T9H-A nrPDB Length = 307 Score = 35.3 bits (79), Expect = 0.12, Method: Composition-based stats. Identities = 28/181 (15%), Positives = 62/181 (34%), Gaps = 21/181 (11%) Query: 53 EARFTDTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFS 112 E+ +D + RGI K+ L + + D +L+ + + + Sbjct: 28 ESEDSDKVIQCRGRGIFRKNKITPLVGDYVVYQA-----ENDKEGYLMEI------KERT 76 Query: 113 SEVTAA-LRVTDGALVVVDTIEGVCVQTETVLR-----QALGERIKPVVVINKVDR-ALL 165 +E+ + D A++V V T L I+P++ I K+D Sbjct: 77 NELIRPPICNVDQAVLVFSA---VQPSFSTALLDRFLVLVEANDIQPIICITKMDLIEDQ 133 Query: 166 ELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQF 225 + + + + + + V + S D + + + + TV G G + + Sbjct: 134 DTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIPHFQDKTTVFAGQSGVGKSSLLNAI 193 Query: 226 A 226 + Sbjct: 194 S 194 >1Z22-A nrPDB Length = 168 Score = 35.3 bits (79), Expect = 0.13, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 54/158 (34%), Gaps = 21/158 (13%) Query: 59 TRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDF---SSEV 115 + +GI Y + D E + + + + L D+ G +F + Sbjct: 20 SMIQRYCKGI-----FTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAY 74 Query: 116 TAALRVTDGALVVVDTIEGVCVQTETVLR---QALGERIKPVVVINKVDRALLELQVSKE 172 + ++V T + + + R A I +V NK+D LL+ K Sbjct: 75 YRGAQAC---VLVFSTTDRESFEAISSWREKVVAEVGDIPTALVQNKID--LLDDSCIKN 129 Query: 173 DLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVA 210 + + A+ ++ + Y V D+ V +A Sbjct: 130 EEAEGLAKRLK-----LRFYRTSVKEDLNVSEVFKYLA 162 >2GAO-A nrPDB Length = 208 Score = 35.3 bits (79), Expect = 0.13, Method: Composition-based stats. Identities = 26/187 (13%), Positives = 59/187 (31%), Gaps = 33/187 (17%) Query: 30 HGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK-STAISLYSEMSDEDVKE 88 GK+TL ++ + G+ T E+ +TI T + ++ + Sbjct: 46 AGKTTLL-------HMLKDDRLGQHVPTLHPTSEE---LTIAGMTFTTFDLGGHEQARRV 95 Query: 89 IKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALG 148 K + ++ L+D D S V + V+ ++ Sbjct: 96 WKNYLPAINGIVFLVDC---ADHSRLVES------------------KVELNALMTDETI 134 Query: 149 ERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGT 208 + +++ NK+DR + +++ + +T NV + + Sbjct: 135 SNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCS-VLKR 193 Query: 209 VAFGSGL 215 +G G Sbjct: 194 QGYGEGF 200 >5J40-A nrPDB Length = 372 Score = 34.9 bits (78), Expect = 0.16, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 33/102 (32%), Gaps = 15/102 (14%) Query: 7 DQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQ-- 64 + ++ ++ + R +D GK+TL +L+ G S E+ Sbjct: 152 EFLKCIVLNIPKKRYWLFKGPIDSGKTTLAAALLDLCGGKS--------LNVNMPLERLN 203 Query: 65 -ERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDS 105 E G+ I D + + + I+ +D Sbjct: 204 FELGVGID----QFMVVFEDVKGTGAESRDLPSGHGISNLDC 241 >2YKR-W nrPDB Length = 350 Score = 34.1 bits (76), Expect = 0.26, Method: Composition-based stats. Identities = 20/129 (15%), Positives = 42/129 (32%), Gaps = 1/129 (0%) Query: 110 DFSSEVTAALRVTDGALVVVDTIEGVCVQTE-TVLRQALGERIKPVVVINKVDRALLELQ 168 DF V D ++V + + + L +I+P++V+NK+D E Sbjct: 111 DFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEPIIVLNKIDLLDDEGM 170 Query: 169 VSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATR 228 + + V ++ S D + + R ++ G G + + Sbjct: 171 AFVNEQMDIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLGL 230 Query: 229 YAKKFGVDK 237 + D Sbjct: 231 QKEILTNDV 239 >5NO4-Z nrPDB Length = 313 Score = 34.1 bits (76), Expect = 0.28, Method: Composition-based stats. Identities = 20/129 (15%), Positives = 42/129 (32%), Gaps = 1/129 (0%) Query: 110 DFSSEVTAALRVTDGALVVVDTIEGVCVQTE-TVLRQALGERIKPVVVINKVDRALLELQ 168 DF V D ++V + + + L +I+P++V+NK+D E Sbjct: 78 DFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEPIIVLNKIDLLDDEGM 137 Query: 169 VSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATR 228 + + V ++ S D + + R ++ G G + + Sbjct: 138 AFVNEQMDIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLGL 197 Query: 229 YAKKFGVDK 237 + D Sbjct: 198 QKEILTNDI 206 >3A1W-A nrPDB Length = 168 Score = 34.1 bits (76), Expect = 0.29, Method: Composition-based stats. Identities = 20/98 (20%), Positives = 37/98 (37%), Gaps = 6/98 (6%) Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDF----SSEVTAALRVTDG-AL 126 + + V++ + + INLID PG E A + G A Sbjct: 26 TGTKQYVANWPGVTVEKKEGVFTYKGYTINLIDLPGTYSLGYSSIDEKIARDYLLKGDAD 85 Query: 127 VVVDTIEGVCV-QTETVLRQALGERIKPVVVINKVDRA 163 +V+ + V Q+ +L + L K ++ + +D A Sbjct: 86 LVILVADSVNPEQSLYLLLEILEMEKKVILAMTAIDEA 123 >2ERY-A nrPDB Length = 172 Score = 33.7 bits (75), Expect = 0.31, Method: Composition-based stats. Identities = 22/119 (18%), Positives = 51/119 (42%), Gaps = 8/119 (6%) Query: 70 IKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVV 129 I+S ++ Y + + ED + D + ++++D+ G +F + +R +G L+V Sbjct: 26 IQSYFVTDY-DPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVF 84 Query: 130 DTIEGVCVQT-----ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVE 183 + + +LR + +++ NK D L + ++ Q AR ++ Sbjct: 85 SVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKAD--LDHQRQVTQEEGQQLARQLK 141 >1U0L-A nrPDB Length = 301 Score = 33.7 bits (75), Expect = 0.31, Method: Composition-based stats. Identities = 20/123 (16%), Positives = 43/123 (34%), Gaps = 14/123 (11%) Query: 122 TDGALVVVDTIEGVCVQTETV-----LRQALGERIKPVVVINKVDRALLELQVSKEDLYQ 176 D ++VV +T T L A ++ V+VINK+D + +L + Sbjct: 85 VDQVILVVTVK---MPETSTYIIDKFLVLAEKNELETVMVINKMDLYDEDDLRKVRELEE 141 Query: 177 TFARTVESVN------VIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYA 230 ++ V + + + + G + V S L+ ++ + + Sbjct: 142 IYSGLYPIVKTSAKTGMGIEELKEYLKGKISTMAGLSGVGKSSLLNAINPGLKLRVSEVS 201 Query: 231 KKF 233 +K Sbjct: 202 EKL 204 >4BAS-A nrPDB Length = 199 Score = 33.7 bits (75), Expect = 0.32, Method: Composition-based stats. Identities = 26/187 (13%), Positives = 61/187 (32%), Gaps = 23/187 (12%) Query: 13 MDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKS 72 M + + + + GK+T ++ + ++ + E+G + Sbjct: 11 MGQSKTKLQVVMCGLDNSGKTT----IINQVKPAQSSSKHITATVGYNVETFEKG---RV 63 Query: 73 TAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTI 132 + + + D +I ++DS H LR+ VV + Sbjct: 64 AFTVFDMGGAKKFRGLWETYYDNIDAVIFVVDSSDH----------LRLC-----VVKSE 108 Query: 133 EGVCVQTETVLRQA-LGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVST 191 ++ E + R+ G R+ + NK+D A + ++ + VI ++ Sbjct: 109 IQAMLKHEDIRRELPGGGRVPFLFFANKMDAAGAKTAAELVEILDLTTLMGDHPFVIFAS 168 Query: 192 YADEVLG 198 + G Sbjct: 169 NGLKGTG 175 >3CUE-F nrPDB Length = 206 Score = 33.3 bits (74), Expect = 0.39, Method: Composition-based stats. Identities = 27/118 (22%), Positives = 51/118 (43%), Gaps = 8/118 (6%) Query: 71 KSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130 T + Y D K + DG + + + D+ G F + ++ R + G ++V D Sbjct: 30 DDTYTNDYISTIGVDFKIKTVELDGKTVKLQIWDTAGQERFRTITSSYYRGSHGIIIVYD 89 Query: 131 TIE-----GVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVE 183 + GV + + + R A +K +V NK D L + +V + D+ + FA + Sbjct: 90 VTDQESFNGVKMWLQEIDRYATSTVLKLLVG-NKCD--LKDKRVVEYDVAKEFADANK 144 >1YZN-A nrPDB Length = 185 Score = 33.3 bits (74), Expect = 0.39, Method: Composition-based stats. Identities = 27/118 (22%), Positives = 51/118 (43%), Gaps = 8/118 (6%) Query: 71 KSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130 T + Y D K + DG + + + D+ G F + ++ R + G ++V D Sbjct: 43 DDTYTNDYISTIGVDFKIKTVELDGKTVKLQIWDTAGQERFRTITSSYYRGSHGIIIVYD 102 Query: 131 TIE-----GVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVE 183 + GV + + + R A +K +V NK D L + +V + D+ + FA + Sbjct: 103 VTDQESFNGVKMWLQEIDRYATSTVLKLLVG-NKCD--LKDKRVVEYDVAKEFADANK 157 >4GDF-A nrPDB Length = 497 Score = 33.3 bits (74), Expect = 0.44, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 20/41 (48%) Query: 7 DQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIIS 47 D ++ ++ + R +D GK+TL +L++ G + Sbjct: 277 DFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKA 317 >1SVL-A nrPDB Length = 377 Score = 33.3 bits (74), Expect = 0.44, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 20/41 (48%) Query: 7 DQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIIS 47 D ++ ++ + R +D GK+TL +L++ G + Sbjct: 157 DFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKA 197 >2DYK-A nrPDB Length = 161 Score = 33.3 bits (74), Expect = 0.47, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 45/150 (30%), Gaps = 24/150 (16%) Query: 22 MSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEM 81 + ++ + GKS+L + L+++ + A G R E +RG Sbjct: 4 VVIVGRPNVGKSSLFNRLLKKRSAVVADVPGVTRDLKEGVVETDRG------------RF 51 Query: 82 SDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTET 141 D + + +D AL + L VD + Sbjct: 52 LLVDTGGLWSGDKWEKKIQEKVD------------RALEDAEVVLFAVDGRAELTQADYE 99 Query: 142 VLRQALGERIKPVVVINKVDRALLELQVSK 171 V + ++V KVD EL + Sbjct: 100 VAEYLRRKGKPVILVATKVDDPKHELYLGP 129 >1F6B-A nrPDB Length = 198 Score = 33.3 bits (74), Expect = 0.48, Method: Composition-based stats. Identities = 24/187 (12%), Positives = 55/187 (29%), Gaps = 33/187 (17%) Query: 30 HGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK-STAISLYSEMSDEDVKE 88 GK+TL ++ + G+ T E+ +TI T + + + Sbjct: 36 AGKTTLL-------HMLKDDRLGQHVPTLHPTSEE---LTIAGMTFTTFDLGGHIQARRV 85 Query: 89 IKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALG 148 K + ++ L+D H + T+ + Sbjct: 86 WKNYLPAINGIVFLVDCADHERLLESKEELDSLM----------------TDETI----- 124 Query: 149 ERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGT 208 + +++ NK+DR + +++ + +T +V + L Sbjct: 125 ANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSVSLKELNARPLEVFMCS-VLKR 183 Query: 209 VAFGSGL 215 +G G Sbjct: 184 QGYGEGF 190 >6GNI-B nrPDB Length = 167 Score = 33.3 bits (74), Expect = 0.50, Method: Composition-based stats. Identities = 21/155 (13%), Positives = 43/155 (27%), Gaps = 30/155 (19%) Query: 30 HGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSDEDVKEI 89 GK+TL ++ + + T +E I + + + Sbjct: 12 AGKTTLL-------HMLKNDRLATLQPT-WHPTSEELAIG-NIKFTTFDLGGHIQARRLW 62 Query: 90 KQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGE 149 K + ++ L+D+ F D A V +D + A + Sbjct: 63 KDYFPEVNGIVFLVDAADPERF-----------DEARVELDA----------LFNIAELK 101 Query: 150 RIKPVVVINKVDRALLELQVSKEDLYQTFARTVES 184 + V++ NK+D + T Sbjct: 102 DVPFVILGNKIDAPNAVSEAELRSALGLLNTTGSQ 136 >1M2O-B nrPDB Length = 190 Score = 33.3 bits (74), Expect = 0.50, Method: Composition-based stats. Identities = 21/155 (13%), Positives = 43/155 (27%), Gaps = 30/155 (19%) Query: 30 HGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSDEDVKEI 89 GK+TL ++ + + T +E I + + + Sbjct: 34 AGKTTLL-------HMLKNDRLATLQPT-WHPTSEELAIG-NIKFTTFDLGGHIQARRLW 84 Query: 90 KQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGE 149 K + ++ L+D+ F D A V +D + A + Sbjct: 85 KDYFPEVNGIVFLVDAADPERF-----------DEARVELDA----------LFNIAELK 123 Query: 150 RIKPVVVINKVDRALLELQVSKEDLYQTFARTVES 184 + V++ NK+D + T Sbjct: 124 DVPFVILGNKIDAPNAVSEAELRSALGLLNTTGSQ 158 >6NB0-A nrPDB Length = 287 Score = 33.0 bits (73), Expect = 0.52, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 43/150 (28%), Gaps = 28/150 (18%) Query: 682 RSVRVNILDVTLHADAIHRGGGQ-------IIPTMRRATYAGFLLADPKIQEPVFLVEIQ 734 R + + I G Q I+ T R T A L P P+ Sbjct: 85 RKIDAKDTTAQRALEGIRNGVDQQVKLLESIVDTTRAETKALALKRAPFALRPLL----- 139 Query: 735 CPEQAVGGIYSVLNKKRG------------QVVSEEQRPGTPLFTVKAYLPVNESFGFTG 782 ++ +G + L +RG Q+ + +R L+ + + + G T Sbjct: 140 --DETIGDVREGLAARRGIVLALNTPLAAQQMDGDRERLAAALWLLVTFAVEASASGTTV 197 Query: 783 ELRQATGGQAFPQMVFDHWSTLGSDPLDPT 812 L V W + DP Sbjct: 198 TLDADVDTATLRATV--SWQATPAALTDPA 225 >2G77-B nrPDB Length = 198 Score = 33.0 bits (73), Expect = 0.53, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 49/170 (28%), Gaps = 38/170 (22%) Query: 17 TNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAIS 76 + + + VI + GK+ LT AG D +ER + I Sbjct: 27 SRIFKIIVIGDSNVGKTCLTYR--FCAGRFPDRTEATIGV-----DFRERAVDID----- 74 Query: 77 LYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAAL-RVTDGALVVVD----- 130 G I L D+ G F + R + V D Sbjct: 75 ------------------GERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMA 116 Query: 131 TIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR 180 + + E + L I ++V NK D L DL Q FA Sbjct: 117 SFHSLPAWIEECKQHLLANDIPRILVGNKCD--LRSAIQVPTDLAQKFAD 164 >1Z06-A nrPDB Length = 189 Score = 33.0 bits (73), Expect = 0.53, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 49/170 (28%), Gaps = 38/170 (22%) Query: 17 TNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAIS 76 + + + VI + GK+ LT AG D +ER + I Sbjct: 18 SRIFKIIVIGDSNVGKTCLTYR--FCAGRFPDRTEATIGV-----DFRERAVDID----- 65 Query: 77 LYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAAL-RVTDGALVVVD----- 130 G I L D+ G F + R + V D Sbjct: 66 ------------------GERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMA 107 Query: 131 TIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFAR 180 + + E + L I ++V NK D L DL Q FA Sbjct: 108 SFHSLPAWIEECKQHLLANDIPRILVGNKCD--LRSAIQVPTDLAQKFAD 155 >3CLV-A nrPDB Length = 208 Score = 33.0 bits (73), Expect = 0.55, Method: Composition-based stats. Identities = 25/116 (21%), Positives = 48/116 (41%), Gaps = 17/116 (14%) Query: 100 INLIDSPGHVDFSSEV---TAALRVTDGALVVVDT-IEGVCVQTETVLRQAL-GERIKPV 154 ++ D+ G ++S V A+VV D + +T + Q + Sbjct: 95 FDIWDTAGQERYASIVPLYYRGAT---CAIVVFDISNSNTLDRAKTWVNQLKISSNYIII 151 Query: 155 VVINKVDRA-----LLELQVSKED----LYQTFARTVESVNVIVSTYADEVLGDVQ 201 +V NK+D+ +LE+Q +D QT A+T ++ I A+E+ ++ Sbjct: 152 LVANKIDKNKFQVDILEVQKYAQDNNLLFIQTSAKTGTNIKNIFYMLAEEIYKNII 207 >3RAP-R nrPDB Length = 167 Score = 33.0 bits (73), Expect = 0.60, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 42/95 (44%), Gaps = 5/95 (5%) Query: 72 STAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD- 130 + + + ED + + D + ++ ++D+ G F+S ++ G ++V Sbjct: 25 TGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSL 84 Query: 131 ----TIEGVCVQTETVLRQALGERIKPVVVINKVD 161 + + + + ++R E++ ++V NKVD Sbjct: 85 VNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVD 119 >5CLL-A nrPDB Length = 191 Score = 33.0 bits (73), Expect = 0.61, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 29/87 (33%), Gaps = 3/87 (3%) Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 Y +V + T+ N+ D+ G F A+++ D V Sbjct: 39 YVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTY 98 Query: 138 QTETVLRQALG---ERIKPVVVINKVD 161 + + L E I V+ NKVD Sbjct: 99 KNVPNWHRDLVRVCENIPIVLCGNKVD 125 >5WDQ-A nrPDB Length = 170 Score = 33.0 bits (73), Expect = 0.63, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 44/108 (40%), Gaps = 7/108 (6%) Query: 68 ITIKSTAISL--YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 +TI+ + + ED + DG + L++++D+ G ++S+ +R +G Sbjct: 23 LTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGF 82 Query: 126 LVVVDTIEGVCVQTETVLRQALGE-----RIKPVVVINKVDRALLELQ 168 L V + R+ + + V+V NK D A ++ Sbjct: 83 LCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDAAARTVE 130 >2EP7-A nrPDB Length = 342 Score = 33.0 bits (73), Expect = 0.63, Method: Composition-based stats. Identities = 25/142 (17%), Positives = 48/142 (33%), Gaps = 12/142 (8%) Query: 102 LIDSPGHVDFSSEV---------TAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIK 152 L+D P H DF T G V+ ++G T + G I Sbjct: 187 LLDLP-HKDFRRARAAAINIVPTTTGAAKAIGE--VIPELKGKLDGTARRVPVPDGSLID 243 Query: 153 PVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFG 212 VV+NK ++ E+ + Q + + + + Y ++ + + + F Sbjct: 244 LTVVVNKAPSSVEEVNEKFREAAQKYRESGKVYLKEILQYCEDPIVSTDIVGNPHSAIFD 303 Query: 213 SGLHGWAFTIRQFATRYAKKFG 234 + L + A Y ++G Sbjct: 304 APLTQVIDNLVHIAAWYDNEWG 325 >4M8N-E nrPDB Length = 199 Score = 33.0 bits (73), Expect = 0.64, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 45/112 (40%), Gaps = 15/112 (13%) Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQ 138 + + ED + + D ++ ++D+ G F++ ++ G +V Q Sbjct: 35 YDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSIT----AQ 90 Query: 139 T---------ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFART 181 + E +LR + + ++V NK D L + +V ++ Q AR Sbjct: 91 STFNDLQDLREQILRVKDTDDVPMILVGNKCD--LEDERVVGKEQGQNLARQ 140 >4DXA-A nrPDB Length = 169 Score = 33.0 bits (73), Expect = 0.64, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 45/112 (40%), Gaps = 15/112 (13%) Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQ 138 + + ED + + D ++ ++D+ G F++ ++ G +V Q Sbjct: 34 YDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSIT----AQ 89 Query: 139 T---------ETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFART 181 + E +LR + + ++V NK D L + +V ++ Q AR Sbjct: 90 STFNDLQDLREQILRVKDTDDVPMILVGNKCD--LEDERVVGKEQGQNLARQ 139 >5UWI-A nrPDB Length = 237 Score = 32.6 bits (72), Expect = 0.66, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 29/87 (33%), Gaps = 3/87 (3%) Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 Y +V + T+ N+ D+ G F A+++ D V Sbjct: 60 YVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTY 119 Query: 138 QTETVLRQALG---ERIKPVVVINKVD 161 + + L E I V+ NKVD Sbjct: 120 KNVPNWHRDLVRVCENIPIVLCGNKVD 146 >2N1B-A nrPDB Length = 261 Score = 32.6 bits (72), Expect = 0.66, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 29/87 (33%), Gaps = 3/87 (3%) Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 Y +V + T+ N+ D+ G F A+++ D V Sbjct: 80 YVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTY 139 Query: 138 QTETVLRQALG---ERIKPVVVINKVD 161 + + L E I V+ NKVD Sbjct: 140 KNVPNWHRDLVRVCENIPIVLCGNKVD 166 >2OCB-A nrPDB Length = 180 Score = 32.6 bits (72), Expect = 0.68, Method: Composition-based stats. Identities = 28/153 (18%), Positives = 55/153 (35%), Gaps = 28/153 (18%) Query: 30 HGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSDEDVKEI 89 GKS L ++ G + G++ + R +T K + + ++ + +++ Sbjct: 2 SGKSLLLKVILLGDGGV-----GKSSLMN-------RYVTNKFDSQAFHTIGVEFLNRDL 49 Query: 90 KQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVL------ 143 + DG + + D+ G F S T R D L+ + Q+ L Sbjct: 50 --EVDGRFVTLQIWDTAGQERFKSLRTPFYRGADCCLLTFSVDD---RQSFENLGNWQKE 104 Query: 144 -----RQALGERIKPVVVINKVDRALLELQVSK 171 E VV+ NKVD+ ++ + Sbjct: 105 FIYYADVKDPEHFPFVVLGNKVDKEDRQVTTEE 137 >5FHF-A nrPDB Length = 433 Score = 32.6 bits (72), Expect = 0.71, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 20/41 (48%), Gaps = 2/41 (4%) Query: 5 TVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGI 45 + ++ +L+ N N+ V GK+T L++++G Sbjct: 9 EMQKIMNLIQDDEN--NVFVTGKAGSGKTTFLKYLIEKSGK 47 >4WA7-A nrPDB Length = 170 Score = 32.6 bits (72), Expect = 0.80, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 38/89 (42%), Gaps = 5/89 (5%) Query: 78 YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV 137 + + ED + DG + L++++D+ G ++S+ +R +G L V Sbjct: 32 EYDPTIEDSYRKQVVIDGETCLLDILDTAGLEEYSAMRDQYMRTGEGFLCVFAINNTKSF 91 Query: 138 QTETVLRQALG-----ERIKPVVVINKVD 161 + R+ + E + V+V NK D Sbjct: 92 EDIHHYREQIKRVKDSEDVPMVLVGNKCD 120 >1R9X-A nrPDB Length = 430 Score = 32.2 bits (71), Expect = 0.87, Method: Composition-based stats. Identities = 12/33 (36%), Positives = 14/33 (42%) Query: 123 DGALVVVDTIEGVCVQTETVLRQALGERIKPVV 155 DG + +D GV TE L G I P V Sbjct: 30 DGKISAIDAQSGVMPITENSLDAEQGLVIPPFV 62 >2KE5-A nrPDB Length = 174 Score = 32.2 bits (71), Expect = 0.94, Method: Composition-based stats. Identities = 24/107 (22%), Positives = 42/107 (39%), Gaps = 7/107 (6%) Query: 79 SEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIE----- 133 E + D K DG I+++D+ G D+++ R +G L+V E Sbjct: 32 YEPTKADSYRKKVVLDGEEVQIDILDTAGLEDYAAIRDNYFRSGEGFLLVFSITEHESFT 91 Query: 134 -GVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFA 179 + + + +A ++I +VV NK D QV E+ Sbjct: 92 ATAEFREQILRVKAEEDKIPLLVVGNKSD-LEERRQVPVEEARSKAE 137 >5L3S-A nrPDB Length = 298 Score = 32.2 bits (71), Expect = 0.95, Method: Composition-based stats. Identities = 27/159 (16%), Positives = 54/159 (33%), Gaps = 31/159 (19%) Query: 22 MSVIAHVDHGKSTLTDSLVQ-------RAGIISAAKAGEARFTDTRKDEQERGITIKSTA 74 + V GK+T L + G+++A A + + + G+ + Sbjct: 108 VGVQG---SGKTTTAGKLAYFYKKRGYKVGLVAADVYRPAAYDQLLQLGNQIGVQVYG-- 162 Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDF---------SSEVTAALRVTDGA 125 ++ E K+ N I ++D+ G + E+ L+ D Sbjct: 163 -EPNNQNPIEIAKKGVDIFVKNKMDIIIVDTAGRHGYGEETKLLEEMKEMYDVLKP-DDV 220 Query: 126 LVVVDTIEGVCVQTETVLRQALGER-IKPV--VVINKVD 161 ++V+D G + A P+ V+I K+D Sbjct: 221 ILVIDASIG-----QKAYDLASRFHQASPIGSVIITKMD 254 >1QZX-A nrPDB Length = 440 Score = 31.8 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 27/159 (16%), Positives = 54/159 (33%), Gaps = 31/159 (19%) Query: 22 MSVIAHVDHGKSTLTDSLVQ-------RAGIISAAKAGEARFTDTRKDEQERGITIKSTA 74 + V GK+T L + G+++A A + + + G+ + Sbjct: 110 VGVQG---SGKTTTAGKLAYFYKKRGYKVGLVAADVYRPAAYDQLLQLGNQIGVQVYG-- 164 Query: 75 ISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDF---------SSEVTAALRVTDGA 125 ++ E K+ N I ++D+ G + E+ L+ D Sbjct: 165 -EPNNQNPIEIAKKGVDIFVKNKMDIIIVDTAGRHGYGEETKLLEEMKEMYDVLKP-DDV 222 Query: 126 LVVVDTIEGVCVQTETVLRQALGER-IKPV--VVINKVD 161 ++V+D G + A P+ V+I K+D Sbjct: 223 ILVIDASIG-----QKAYDLASRFHQASPIGSVIITKMD 256 >3CON-A nrPDB Length = 190 Score = 31.8 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 43/101 (42%), Gaps = 7/101 (6%) Query: 68 ITIKSTAISL--YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 +TI+ + + ED + DG + L++++D+ G ++S+ +R +G Sbjct: 37 LTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGF 96 Query: 126 LVVVDTIEG-----VCVQTETVLRQALGERIKPVVVINKVD 161 L V + + E + R + + V+V NK D Sbjct: 97 LCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCD 137 >4PHF-A nrPDB Length = 184 Score = 31.4 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 24/166 (14%), Positives = 50/166 (30%), Gaps = 21/166 (12%) Query: 26 AHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSDED 85 H+ K + ++ + D + + TI + ++ + + Sbjct: 1 GHMSSRKKNILKVIILGDSGVGKTSLMHRYVNDKYSCQYKA--TIGADFLTKEVTVDGDK 58 Query: 86 VKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLR- 144 V ++ D+ G F S A R D ++V D + R Sbjct: 59 VATMQVW-----------DTAGQERFQSLGVAFYRGADCCVLVYDVTNASSFENIKSWRD 107 Query: 145 ----QALG---ERIKPVVVINKVDRALLELQVSKEDLYQTFARTVE 183 A E V++ NK+D + VS++ + + Sbjct: 108 EFLVHANVNSPETFPFVILGNKIDAEESKKIVSEKSAQELAKSLGD 153 >5UHV-A nrPDB Length = 166 Score = 31.4 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 43/101 (42%), Gaps = 7/101 (6%) Query: 68 ITIKSTAISL--YSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGA 125 +TI+ + + ED + DG + L++++D+ G ++S+ +R +G Sbjct: 19 LTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGF 78 Query: 126 LVVVDTIEG-----VCVQTETVLRQALGERIKPVVVINKVD 161 L V + + E + R + + V+V NK D Sbjct: 79 LCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCD 119 >6FVU-I nrPDB Length = 384 Score = 31.4 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 41/96 (42%), Gaps = 3/96 (3%) Query: 153 PVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFG 212 P+V + K+D++ E L ESV + E+ ++ + P +G + +G Sbjct: 113 PMVSVMKMDKSPTESYSDIGGLESQIQEIKESV--ELPLTHPELYEEMGIKPPKGVILYG 170 Query: 213 SGLHGWAFTIRQFATRYAKKF-GVDKAKMMDRLWGD 247 + G + A + + F + ++++ + GD Sbjct: 171 APGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGD 206 >4FMC-F nrPDB Length = 117 Score = 31.4 bits (69), Expect = 1.7, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 34/95 (35%), Gaps = 4/95 (4%) Query: 71 KSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130 T Y D K + DG + + + D+ G F + ++ R G +VV D Sbjct: 20 DDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYD 79 Query: 131 TIEGVCVQTETVLRQAL----GERIKPVVVINKVD 161 + Q + E + ++V NK D Sbjct: 80 VTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCD 114 >3L0I-B nrPDB Length = 199 Score = 31.4 bits (69), Expect = 1.7, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 34/95 (35%), Gaps = 4/95 (4%) Query: 71 KSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVD 130 T Y D K + DG + + + D+ G F + ++ R G +VV D Sbjct: 55 DDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYD 114 Query: 131 TIEGVCVQTETVLRQAL----GERIKPVVVINKVD 161 + Q + E + ++V NK D Sbjct: 115 VTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCD 149 >3JCP-I nrPDB Length = 437 Score = 31.4 bits (69), Expect = 1.7, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 41/96 (42%), Gaps = 3/96 (3%) Query: 153 PVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFG 212 P+V + K+D++ E L ESV + E+ ++ + P +G + +G Sbjct: 166 PMVSVMKMDKSPTESYSDIGGLESQIQEIKESV--ELPLTHPELYEEMGIKPPKGVILYG 223 Query: 213 SGLHGWAFTIRQFATRYAKKF-GVDKAKMMDRLWGD 247 + G + A + + F + ++++ + GD Sbjct: 224 APGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGD 259 >3OES-A nrPDB Length = 201 Score = 31.4 bits (69), Expect = 1.8, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 36/94 (38%), Gaps = 5/94 (5%) Query: 73 TAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTI 132 S + + E+ + F ++L+D+ G ++S + + G ++V Sbjct: 47 GEFSEGYDPTVENTYSKIVTLGKDEFHLHLVDTAGQDEYSILPYSFIIGVHGYVLVYSVT 106 Query: 133 EGVCVQTETVLRQALGE-----RIKPVVVINKVD 161 Q L Q L E R+ V+V NK D Sbjct: 107 SLHSFQVIESLYQKLHEGHGKTRVPVVLVGNKAD 140 >4MKI-B nrPDB Length = 298 Score = 31.0 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 16/38 (42%) Query: 2 VAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSL 39 + ++ + + + + +I H GKSTL L Sbjct: 20 TPYATVALKDINFSIDDEEFVGIIGHTGSGKSTLIQQL 57 >3PNS-A nrPDB Length = 261 Score = 30.7 bits (67), Expect = 3.0, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 25/65 (38%) Query: 451 GNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKR 510 G I V + ++ TG++ + + M+F P VA +K A + Sbjct: 103 GAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGV 162 Query: 511 LSKSD 515 + SD Sbjct: 163 TASSD 167 >3T5G-A nrPDB Length = 181 Score = 30.3 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 28/147 (19%), Positives = 55/147 (37%), Gaps = 36/147 (24%) Query: 20 RNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYS 79 R ++++ + GKS+LT + E +F D+ TI++T L + Sbjct: 7 RKIAILGYRSVGKSSLT------------IQFVEGQFVDSYD------PTIENTFTKLIT 48 Query: 80 EMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTI-----EG 134 +G + + L+D+ G ++S +G ++V E Sbjct: 49 -------------VNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEV 95 Query: 135 VCVQTETVLRQALGERIKPVVVINKVD 161 + V +L +I ++V NK D Sbjct: 96 IKVIHGKLLDMVGKVQIPIMLVGNKKD 122 >4Z54-A nrPDB Length = 287 Score = 30.3 bits (66), Expect = 3.7, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 39/109 (35%), Gaps = 21/109 (19%) Query: 6 VDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQE 65 ++QMR K N+ V+ GKSTL ++L + + KA ++E+ Sbjct: 6 IEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFK---SQVSRKASS-----WNREEK- 56 Query: 66 RGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSE 114 + + + G + +ID+PG D + Sbjct: 57 ------------IPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINN 93 >1PUJ-A nrPDB Length = 282 Score = 30.3 bits (66), Expect = 3.9, Method: Composition-based stats. Identities = 16/92 (17%), Positives = 43/92 (46%), Gaps = 3/92 (3%) Query: 106 PGHVDFSS-EVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRAL 164 PGH+ + EVT L++ D +VD + + + + + + + ++++NK D+A Sbjct: 7 PGHMAKARREVTEKLKLIDIVYELVDAR--IPMSSRNPMIEDILKNKPRIMLLNKADKAD 64 Query: 165 LELQVSKEDLYQTFARTVESVNVIVSTYADEV 196 + ++ ++ S+N + +++ Sbjct: 65 AAVTQQWKEHFENQGIRSLSINSVNGQGLNQI 96 >5B3F-A nrPDB Length = 343 Score = 29.9 bits (65), Expect = 4.8, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 25/71 (35%), Gaps = 13/71 (18%) Query: 11 SLMDKVTNVRN----------MSVIAHVDHGKSTLTDSLVQRAGI--ISAAKAGEARFTD 58 S M + N R + V GKST T ++ G +S+ + D Sbjct: 19 SHMSQPENFREVIRHSPLVYLIGVAGDSGSGKSTFTRAISDIFGEELVSSITVDDYHLYD 78 Query: 59 TRKDEQERGIT 69 K E GIT Sbjct: 79 R-KTRSEMGIT 88 >4JYC-A nrPDB Length = 337 Score = 29.9 bits (65), Expect = 5.3, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 59/175 (33%), Gaps = 23/175 (13%) Query: 7 DQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGII-----------SAAKAGEAR 55 D + +++ + + + GKST D+L S+ + G + Sbjct: 43 DLIDAVLPQTGRAIRVGITGVPGVGKSTTIDALGSLLTAAGHKVAVLAVDPSSTRTGGSI 102 Query: 56 FTDTRKDEQ---ERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFS 112 D + + +R I+ + S +E + F + L+++ G Sbjct: 103 LGDKTRMARLAIDRNAFIRPSPSSGTLGGVAAKTRETMLLCEAAGFDVILVETVG----V 158 Query: 113 SEVTAA-LRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLE 166 + A +TD LV++ G +Q + ++ +NK D E Sbjct: 159 GQSETAVADLTDFFLVLMLPGAGDELQGIKK----GIFELADMIAVNKADDGDGE 209 >1TMF-3 nrPDB Length = 232 Score = 29.5 bits (64), Expect = 6.5, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 16/42 (38%) Query: 706 IPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVL 747 IP R F +P P++ I P + G +S L Sbjct: 3 IPVTVREHKGCFYSTNPDTTVPIYGKTISTPSDYMCGEFSDL 44 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.114 0.282 Lambda K H 0.267 0.0348 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,847,017 Number of Sequences: 36641 Number of extensions: 983055 Number of successful extensions: 3804 Number of sequences better than 10.0: 177 Number of HSP's better than 10.0 without gapping: 182 Number of HSP's successfully gapped in prelim test: 92 Number of HSP's that attempted gapping in prelim test: 3049 Number of HSP's gapped (non-prelim): 369 length of query: 842 length of database: 10,336,785 effective HSP length: 105 effective length of query: 737 effective length of database: 6,489,480 effective search space: 4782746760 effective search space used: 4782746760 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 63 (29.1 bits)