BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P31749 (480 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5KCV-A nrPDB 922 0.0 3MV5-A nrPDB 700 0.0 2JDO-A nrPDB 590 e-169 3TXO-A nrPDB 328 3e-90 3HDN-A nrPDB 328 4e-90 3PFQ-A nrPDB 316 2e-86 3A8W-A nrPDB 314 5e-86 2I0E-A nrPDB 313 2e-85 4RA4-A nrPDB 312 2e-85 4L42-A nrPDB 299 2e-81 4OTD-A nrPDB 295 2e-80 5F9E-A nrPDB 292 3e-79 4CRS-A nrPDB 291 3e-79 5D9K-A nrPDB 281 3e-76 4RLP-A nrPDB 277 9e-75 2Z7Q-A nrPDB 275 3e-74 4WB7-A nrPDB 267 6e-72 5X3F-B nrPDB 267 9e-72 5N23-A nrPDB 267 9e-72 2UVM-A nrPDB 261 3e-70 1VZO-A nrPDB 257 7e-69 1FOT-A nrPDB 257 8e-69 6BDL-A nrPDB 214 6e-56 5LOH-A nrPDB 212 4e-55 2X18-A nrPDB 209 2e-54 3NYO-A nrPDB 208 3e-54 4TNB-A nrPDB 208 5e-54 5UUU-A nrPDB 203 1e-52 3PVW-A nrPDB 203 1e-52 3TKU-A nrPDB 201 6e-52 5FET-A nrPDB 197 8e-51 4AW2-A nrPDB 196 3e-50 3ORZ-A nrPDB 194 7e-50 5DYK-A nrPDB 193 1e-49 4YHJ-A nrPDB 193 2e-49 6E9W-A nrPDB 190 1e-48 3C51-A nrPDB 190 1e-48 4FR4-A nrPDB 187 1e-47 6ED6-A nrPDB 184 9e-47 4LQP-A nrPDB 181 8e-46 2VD5-A nrPDB 179 3e-45 6BXI-A nrPDB 177 1e-44 2JC6-A nrPDB 167 1e-41 4FG9-A nrPDB 165 4e-41 3MN3-A nrPDB 165 5e-41 4REW-A nrPDB 161 5e-40 4CFH-A nrPDB 161 6e-40 5ES1-A nrPDB 161 7e-40 4CZT-A nrPDB 160 8e-40 2QNJ-A nrPDB 160 1e-39 4RED-A nrPDB 159 2e-39 5KZ7-A nrPDB 159 3e-39 4CFF-A nrPDB 158 5e-39 5EZV-A nrPDB 158 5e-39 4C0T-A nrPDB 157 8e-39 2JAM-A nrPDB 157 8e-39 2YZA-A nrPDB 153 1e-37 3H4J-B nrPDB 152 2e-37 4D28-A nrPDB 152 3e-37 2HAK-A nrPDB 150 1e-36 6C9D-A nrPDB 149 3e-36 4B8L-A nrPDB 149 4e-36 4UZD-A nrPDB 147 1e-35 4CQG-A nrPDB 147 1e-35 5IG1-A nrPDB 146 2e-35 4D2V-A nrPDB 145 5e-35 3D2K-A nrPDB 144 9e-35 2W4O-A nrPDB 142 3e-34 5JZN-A nrPDB 142 3e-34 5FG8-A nrPDB 141 7e-34 5YKS-A nrPDB 141 7e-34 5WAX-A nrPDB 140 9e-34 3UC3-A nrPDB 140 1e-33 2BDW-A nrPDB 140 1e-33 4AF3-A nrPDB 140 2e-33 3KK8-A nrPDB 140 2e-33 4YNZ-A nrPDB 139 2e-33 4JXF-A nrPDB 139 4e-33 3UDB-A nrPDB 138 4e-33 2VN9-A nrPDB 137 7e-33 4B6L-A nrPDB 137 8e-33 5XZW-A nrPDB 136 2e-32 3HZT-A nrPDB 136 2e-32 2OU7-A nrPDB 136 2e-32 3ZUT-A nrPDB 136 2e-32 3DXN-A nrPDB 135 3e-32 4J52-A nrPDB 135 3e-32 2V7O-A nrPDB 135 6e-32 4I6B-A nrPDB 133 2e-31 5U6Y-A nrPDB 133 2e-31 3BHH-A nrPDB 132 2e-31 2VZ6-A nrPDB 132 3e-31 3DB8-A nrPDB 132 3e-31 6CMJ-A nrPDB 132 4e-31 4PDS-A nrPDB 132 4e-31 3SOA-A nrPDB 131 6e-31 4APC-A nrPDB 131 8e-31 6FD3-A nrPDB 130 9e-31 3Q53-A nrPDB 130 1e-30 3KN6-A nrPDB 129 2e-30 3F3Z-A nrPDB 128 5e-30 2Y7J-A nrPDB 128 5e-30 4MVF-A nrPDB 127 1e-29 5YV8-A nrPDB 126 2e-29 3FXW-A nrPDB 125 6e-29 4FIE-A nrPDB 124 6e-29 2YAB-A nrPDB 124 8e-29 1PHK-A nrPDB 124 1e-28 2J90-A nrPDB 124 1e-28 2Q0N-A nrPDB 124 1e-28 3NCG-A nrPDB 124 1e-28 4JDH-A nrPDB 124 1e-28 4XBR-A nrPDB 123 1e-28 3DFA-A nrPDB 123 2e-28 5JN2-A nrPDB 122 3e-28 2YCR-A nrPDB 122 4e-28 3MA6-A nrPDB 122 5e-28 4YZB-A nrPDB 121 8e-28 4NIF-A nrPDB 120 1e-27 2A27-A nrPDB 120 1e-27 3I6U-A nrPDB 119 2e-27 1ZWS-A nrPDB 119 2e-27 6FDY-U nrPDB 118 5e-27 2F57-A nrPDB 117 8e-27 4KS7-A nrPDB 117 8e-27 3LIJ-A nrPDB 117 1e-26 4RGJ-A nrPDB 116 2e-26 2HW6-A nrPDB 115 3e-26 3TAC-A nrPDB 115 4e-26 4FZF-B nrPDB 114 7e-26 3IS5-A nrPDB 113 2e-25 1KOB-A nrPDB 113 2e-25 1NY3-A nrPDB 113 2e-25 2OZA-A nrPDB 112 2e-25 4JG6-A nrPDB 112 3e-25 1KOA-A nrPDB 112 4e-25 6HXF-B nrPDB 112 4e-25 3UTO-A nrPDB 112 5e-25 3GUB-A nrPDB 112 5e-25 5J5T-A nrPDB 110 1e-24 6CCF-A nrPDB 110 1e-24 3KA0-A nrPDB 110 1e-24 3LM0-A nrPDB 110 1e-24 4WNO-A nrPDB 110 1e-24 2XIK-A nrPDB 110 1e-24 2X4F-A nrPDB 109 2e-24 4QMW-A nrPDB 109 3e-24 6CKI-A nrPDB 109 3e-24 3Q5I-A nrPDB 106 3e-23 3PPZ-A nrPDB 106 3e-23 3COM-A nrPDB 104 7e-23 4LG4-A nrPDB 103 1e-22 2UV2-A nrPDB 103 2e-22 3DLS-A nrPDB 103 2e-22 6AO5-A nrPDB 103 2e-22 3HKO-A nrPDB 101 6e-22 5VO2-A nrPDB 101 8e-22 6QAU-A nrPDB 101 9e-22 4AN9-A nrPDB 100 2e-21 6CQF-A nrPDB 99 3e-21 5L2Q-C nrPDB 99 3e-21 5KKR-C nrPDB 99 4e-21 3EQC-A nrPDB 98 8e-21 1S9I-A nrPDB 98 8e-21 5D7A-A nrPDB 97 1e-20 3ZDU-A nrPDB 97 2e-20 1TKI-A nrPDB 97 2e-20 6E2O-A nrPDB 97 2e-20 2WQN-A nrPDB 97 2e-20 4KIK-B nrPDB 96 3e-20 3DAK-A nrPDB 95 6e-20 5O0Y-A nrPDB 95 8e-20 4UY9-A nrPDB 94 1e-19 4X7Q-B nrPDB 93 2e-19 2WTK-C nrPDB 93 2e-19 3DTC-A nrPDB 92 5e-19 5DBX-A nrPDB 92 5e-19 4GS6-A nrPDB 92 5e-19 3QA8-A nrPDB 91 1e-18 5HI2-A nrPDB 91 1e-18 4UYA-A nrPDB 91 1e-18 2BRG-A nrPDB 89 3e-18 5CEK-A nrPDB 89 4e-18 6DC0-A nrPDB 89 4e-18 5B2L-A nrPDB 88 9e-18 4U41-A nrPDB 87 1e-17 4EWQ-A nrPDB 87 1e-17 5TQX-A nrPDB 87 1e-17 4AGU-A nrPDB 87 2e-17 2XNP-A nrPDB 87 2e-17 4IC8-A nrPDB 86 2e-17 4ZSG-A nrPDB 86 3e-17 4BBM-A nrPDB 86 3e-17 5O2C-A nrPDB 86 4e-17 3M42-A nrPDB 86 4e-17 4QNY-A nrPDB 86 5e-17 4IDT-A nrPDB 86 5e-17 5HIE-A nrPDB 85 5e-17 5O2B-A nrPDB 85 6e-17 2BPM-A nrPDB 85 6e-17 4BGQ-A nrPDB 85 7e-17 4TPT-A nrPDB 85 8e-17 1UA2-A nrPDB 85 8e-17 4KRC-A nrPDB 84 1e-16 5HVK-A nrPDB 84 2e-16 1CM8-A nrPDB 83 3e-16 5ZTN-A nrPDB 83 3e-16 3OHT-A nrPDB 83 3e-16 1U5R-A nrPDB 83 3e-16 4HVI-A nrPDB 83 3e-16 5VD3-A nrPDB 83 3e-16 2GCD-A nrPDB 83 3e-16 2PMN-X nrPDB 82 4e-16 2A1A-B nrPDB 82 5e-16 3QUP-A nrPDB 82 7e-16 3VN9-A nrPDB 81 9e-16 2F9G-A nrPDB 81 1e-15 6DTL-A nrPDB 81 1e-15 4PWN-A nrPDB 81 1e-15 4X3F-A nrPDB 81 1e-15 4OW8-A nrPDB 80 1e-15 1ZXE-A nrPDB 80 2e-15 5G6V-A nrPDB 80 2e-15 5AMN-A nrPDB 80 2e-15 5X5O-A nrPDB 80 2e-15 3OMV-A nrPDB 80 2e-15 1K9A-A nrPDB 80 2e-15 1BYG-A nrPDB 80 3e-15 6B2Q-A nrPDB 79 3e-15 4Y93-A nrPDB 79 4e-15 4YFF-A nrPDB 79 6e-15 3FME-A nrPDB 78 7e-15 2XYN-A nrPDB 78 1e-14 6J5U-C nrPDB 77 1e-14 2WO6-A nrPDB 77 1e-14 6GU6-A nrPDB 77 1e-14 3ORP-A nrPDB 77 2e-14 5FM2-A nrPDB 77 2e-14 3LLT-A nrPDB 77 2e-14 3ALO-A nrPDB 77 2e-14 3UIU-A nrPDB 76 3e-14 6CTH-A nrPDB 75 4e-14 4G3E-A nrPDB 75 5e-14 3E3P-A nrPDB 75 5e-14 4CSV-A nrPDB 75 6e-14 5TOS-A nrPDB 75 6e-14 5TUR-A nrPDB 75 7e-14 4MYG-A nrPDB 75 8e-14 4RC3-A nrPDB 75 8e-14 6NPU-A nrPDB 74 1e-13 5Y86-A nrPDB 74 1e-13 3BGP-A nrPDB 74 1e-13 6GVJ-A nrPDB 74 1e-13 4XI2-A nrPDB 74 1e-13 1V0B-A nrPDB 74 2e-13 4NST-A nrPDB 74 2e-13 4XEY-B nrPDB 73 2e-13 5X8I-B nrPDB 73 2e-13 6E4F-A nrPDB 73 3e-13 3QGY-A nrPDB 73 3e-13 3NIZ-A nrPDB 73 3e-13 3GC9-A nrPDB 73 3e-13 5AIR-A nrPDB 72 5e-13 5H2U-A nrPDB 72 5e-13 2FO0-A nrPDB 72 5e-13 2QKW-B nrPDB 72 6e-13 3HMP-A nrPDB 72 7e-13 6DBN-A nrPDB 72 7e-13 4EQM-A nrPDB 71 8e-13 4AU8-A nrPDB 71 8e-13 4JLC-A nrPDB 71 9e-13 4OLI-A nrPDB 71 1e-12 4E93-A nrPDB 71 1e-12 5Z33-A nrPDB 70 2e-12 4NEU-A nrPDB 70 2e-12 5AP3-A nrPDB 70 3e-12 4EUT-A nrPDB 69 3e-12 5EFQ-A nrPDB 69 3e-12 6DBM-A nrPDB 69 4e-12 4F0G-A nrPDB 69 4e-12 4EUU-A nrPDB 69 4e-12 5WNO-A nrPDB 69 4e-12 3OZ6-A nrPDB 69 4e-12 2ZMD-A nrPDB 69 4e-12 1FVR-A nrPDB 69 4e-12 3MIA-A nrPDB 69 5e-12 6NT9-A nrPDB 69 5e-12 4E7W-A nrPDB 69 7e-12 3IO7-A nrPDB 68 8e-12 6FER-A nrPDB 68 1e-11 4QTB-A nrPDB 68 1e-11 2J0K-A nrPDB 68 1e-11 6O8B-A nrPDB 68 1e-11 4EBW-A nrPDB 68 1e-11 1G3N-A nrPDB 67 1e-11 5NGU-A nrPDB 67 1e-11 3BEA-A nrPDB 67 1e-11 2W1I-A nrPDB 67 1e-11 4O2Z-A nrPDB 67 1e-11 5AWM-A nrPDB 67 2e-11 3C1X-A nrPDB 67 2e-11 3E7O-A nrPDB 67 2e-11 6HMD-A nrPDB 66 3e-11 4H1J-A nrPDB 66 4e-11 4K33-A nrPDB 66 4e-11 5A46-A nrPDB 66 4e-11 2XS0-A nrPDB 65 4e-11 4M7I-A nrPDB 65 5e-11 2PSQ-A nrPDB 65 5e-11 3SXS-A nrPDB 65 6e-11 5HLW-A nrPDB 65 8e-11 3RAW-A nrPDB 65 8e-11 3GC0-A nrPDB 65 9e-11 6FYV-A nrPDB 64 1e-10 3TT0-A nrPDB 64 1e-10 3CJF-A nrPDB 64 1e-10 1U59-A nrPDB 64 1e-10 2OZO-A nrPDB 64 1e-10 3GQL-A nrPDB 64 1e-10 4E20-A nrPDB 64 1e-10 1LUF-A nrPDB 64 1e-10 3KUL-B nrPDB 64 1e-10 4XCU-A nrPDB 64 2e-10 6EII-A nrPDB 64 2e-10 2RIO-A nrPDB 64 2e-10 1JNK-A nrPDB 64 2e-10 4HZS-A nrPDB 63 2e-10 1U54-B nrPDB 63 3e-10 5UIU-A nrPDB 63 3e-10 6F3F-A nrPDB 63 3e-10 3V5Q-A nrPDB 63 3e-10 4MD7-E nrPDB 62 4e-10 3QD2-B nrPDB 62 4e-10 5U6C-A nrPDB 62 4e-10 3KRL-A nrPDB 62 5e-10 3UIM-A nrPDB 62 5e-10 5U6B-A nrPDB 62 5e-10 2VWV-A nrPDB 62 5e-10 2W96-B nrPDB 62 6e-10 3DKO-A nrPDB 62 6e-10 2OGV-A nrPDB 62 7e-10 2DQ7-X nrPDB 62 7e-10 2H8H-A nrPDB 62 8e-10 5EG3-A nrPDB 61 8e-10 5SYS-A nrPDB 61 9e-10 5L6P-A nrPDB 61 1e-09 2Y6O-A nrPDB 60 1e-09 2I6L-A nrPDB 60 1e-09 5AR8-A nrPDB 60 2e-09 5J0A-A nrPDB 60 2e-09 4AT3-A nrPDB 60 2e-09 1JPA-A nrPDB 60 2e-09 5UNP-A nrPDB 60 2e-09 3FI2-A nrPDB 60 2e-09 4XLV-A nrPDB 60 3e-09 5GRN-A nrPDB 59 3e-09 5LPZ-A nrPDB 59 4e-09 5IKW-A nrPDB 59 4e-09 6GQK-A nrPDB 59 4e-09 5OAT-A nrPDB 59 5e-09 5LPV-A nrPDB 59 5e-09 2H34-A nrPDB 59 5e-09 4R7H-A nrPDB 59 5e-09 3A4O-X nrPDB 59 6e-09 2BUJ-A nrPDB 59 6e-09 5MJB-A nrPDB 59 6e-09 4Y83-A nrPDB 58 7e-09 2Y4I-B nrPDB 58 7e-09 6FEX-A nrPDB 58 7e-09 3BBT-B nrPDB 58 8e-09 1AD5-A nrPDB 58 1e-08 4LFI-A nrPDB 58 1e-08 3EB0-A nrPDB 58 1e-08 2HK5-A nrPDB 58 1e-08 5WNL-A nrPDB 58 1e-08 2PL0-A nrPDB 57 1e-08 4PDO-A nrPDB 57 1e-08 4FL3-A nrPDB 57 1e-08 2R2P-A nrPDB 57 1e-08 1PY5-A nrPDB 57 2e-08 3HNG-A nrPDB 57 2e-08 2PVN-A nrPDB 56 3e-08 3Q4U-A nrPDB 56 3e-08 5C26-A nrPDB 56 3e-08 4P5Q-A nrPDB 56 3e-08 6BSD-A nrPDB 56 3e-08 4PL5-B nrPDB 56 4e-08 5XVU-A nrPDB 56 4e-08 5KMM-A nrPDB 56 4e-08 6O6Q-A nrPDB 55 5e-08 3G2F-A nrPDB 55 5e-08 3PG1-A nrPDB 55 5e-08 3MDY-A nrPDB 55 6e-08 3G0E-A nrPDB 55 6e-08 5M07-A nrPDB 55 6e-08 5XD6-A nrPDB 55 6e-08 4XUF-A nrPDB 55 7e-08 3PLS-A nrPDB 55 7e-08 5X02-A nrPDB 55 8e-08 3RP9-A nrPDB 55 9e-08 5TE0-A nrPDB 55 9e-08 4F9B-A nrPDB 54 1e-07 5E8V-A nrPDB 54 1e-07 6HV0-A nrPDB 54 2e-07 4C59-A nrPDB 54 2e-07 3AOX-A nrPDB 53 3e-07 2CMW-A nrPDB 53 3e-07 3PP0-A nrPDB 53 4e-07 2CHL-A nrPDB 52 5e-07 3VHK-A nrPDB 52 5e-07 4M66-A nrPDB 52 6e-07 3I81-A nrPDB 52 8e-07 4IAN-A nrPDB 51 9e-07 5GNK-A nrPDB 51 1e-06 3ZBF-A nrPDB 51 1e-06 4CRL-A nrPDB 51 1e-06 3NIE-A nrPDB 51 1e-06 3N9X-A nrPDB 50 2e-06 5C01-A nrPDB 50 2e-06 3LZB-A nrPDB 50 2e-06 4WOV-A nrPDB 50 2e-06 4TN6-A nrPDB 50 3e-06 2JD5-A nrPDB 49 5e-06 3REP-A nrPDB 49 5e-06 6EQI-C nrPDB 48 7e-06 2C47-A nrPDB 48 8e-06 4LRM-A nrPDB 48 1e-05 2PZI-A nrPDB 47 1e-05 3LMG-A nrPDB 47 1e-05 6BFN-A nrPDB 47 1e-05 4Y12-A nrPDB 47 1e-05 3ZZW-A nrPDB 46 3e-05 2QLU-A nrPDB 45 6e-05 4M69-B nrPDB 45 6e-05 3SV0-A nrPDB 45 7e-05 4JRN-A nrPDB 45 8e-05 4BTK-A nrPDB 45 9e-05 6BBQ-A nrPDB 45 9e-05 4BTF-A nrPDB 45 9e-05 2R09-A nrPDB 45 1e-04 4MWI-A nrPDB 44 1e-04 5VC6-A nrPDB 44 2e-04 4NFN-A nrPDB 44 2e-04 3MY0-A nrPDB 44 2e-04 4RT7-A nrPDB 43 2e-04 4NT4-A nrPDB 42 5e-04 3SOC-A nrPDB 42 6e-04 5UV4-A nrPDB 42 6e-04 5X1R-A nrPDB 42 7e-04 5FQD-C nrPDB 42 8e-04 5X18-A nrPDB 40 0.002 5VDK-A nrPDB 40 0.002 4I94-A nrPDB 39 0.005 5CLR-A nrPDB 39 0.005 2W1Z-A nrPDB 39 0.005 4WUA-A nrPDB 38 0.008 2X7G-A nrPDB 38 0.010 5UU1-A nrPDB 37 0.022 3DZO-A nrPDB 37 0.024 3VIA-A nrPDB 36 0.029 1CSN-A nrPDB 36 0.036 6J6I-B nrPDB 35 0.10 3BYV-A nrPDB 34 0.11 3Q60-A nrPDB 34 0.16 4L68-A nrPDB 33 0.22 5USZ-A nrPDB 33 0.25 2DHJ-A nrPDB 33 0.26 2DHI-A nrPDB 33 0.30 2J59-M nrPDB 32 0.62 2D9V-A nrPDB 31 0.91 1V5U-A nrPDB 30 3.4 6E31-A nrPDB 29 4.0 3TCA-A nrPDB 29 4.1 6EMW-E nrPDB 29 4.9 6EM8-A nrPDB 28 7.8 3J3U-A nrPDB 28 9.2 5DMZ-A nrPDB 28 9.5 >5KCV-A nrPDB Length = 460 Score = 922 bits (2382), Expect = 0.0, Method: Compositional matrix adjust. Identities = 442/445 (99%), Positives = 442/445 (99%) Query: 2 SDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQ 61 SDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQ Sbjct: 16 SDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQ 75 Query: 62 LMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFR 121 LMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQ EMDFR Sbjct: 76 LMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQAAAEMDFR 135 Query: 122 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL 181 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL Sbjct: 136 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL 195 Query: 182 KKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR 241 KKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR Sbjct: 196 KKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR 255 Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK Sbjct: 256 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 315 Query: 302 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 361 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI Sbjct: 316 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 375 Query: 362 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKL 421 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKL Sbjct: 376 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKL 435 Query: 422 SPPFKPQVTSETDTRYFDEEFTAQM 446 SPPFKPQVTSETDTRYFDEEFTAQM Sbjct: 436 SPPFKPQVTSETDTRYFDEEFTAQM 460 >3MV5-A nrPDB Length = 342 Score = 700 bits (1806), Expect = 0.0, Method: Compositional matrix adjust. Identities = 335/337 (99%), Positives = 335/337 (99%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ Sbjct: 6 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 65 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY Sbjct: 66 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 125 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED Sbjct: 126 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 185 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL Sbjct: 186 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 245 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 443 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT Sbjct: 246 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 305 Query: 444 AQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480 AQMITITPPDQDDSMECVDSERRPHFPQF YSAS TA Sbjct: 306 AQMITITPPDQDDSMECVDSERRPHFPQFDYSASSTA 342 >2JDO-A nrPDB Length = 342 Score = 590 bits (1522), Expect = e-169, Method: Compositional matrix adjust. Identities = 282/336 (83%), Positives = 310/336 (92%), Gaps = 4/336 (1%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +VTMN+F+YLKLLGKGTFGKVILV+EKATGRYYAMKIL+KEVI+AKDEVAHT+TE+RVLQ Sbjct: 6 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 N+RHPFLTALKY+FQTHDRLCFVMEYANGGELFFHLSRERVF+E+RARFYGAEIVSAL+Y Sbjct: 66 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 125 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LHS ++VVYRD+KLENLMLDKDGHIKITDFGLCKEGI DGATMKTFCGTPEYLAPEVLED Sbjct: 126 LHS-RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 184 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LFELILMEEIRFPRTL PEAKSLL+GL Sbjct: 185 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 244 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 443 LKKDPKQRLGGG DAKE+M+HRFF I WQ V +KKL PPFKPQVTSE DTRYFD+EFT Sbjct: 245 LKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 304 Query: 444 AQMITITPPDQDDSMECVDSERRPH---FPQFSYSA 476 AQ ITITPPD+ DS+ ++ ++R F F Y A Sbjct: 305 AQSITITPPDRYDSLGLLELDQREEQEMFEDFDYIA 340 >3TXO-A nrPDB Length = 353 Score = 328 bits (841), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 152/314 (48%), Positives = 222/314 (70%), Gaps = 3/314 (0%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 +R+ ++ FE++++LGKG+FGKV+L + K TG YA+K+LKK+VI+ D+V T+TE R+L Sbjct: 18 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 77 Query: 203 QNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 +R HPFLT L FQT DRL FVME+ NGG+L FH+ + R F E RARFY AEI+SAL Sbjct: 78 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 137 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +LH +K ++YRDLKL+N++LD +GH K+ DFG+CKEGI +G T TFCGTP+Y+APE+L Sbjct: 138 MFLH-DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 ++ YG AVDWW +GV++YEM+CG PF ++ + LFE IL +E+ +P L +A +L Sbjct: 197 QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILK 256 Query: 382 GLLKKDPKQRLGGGSEDAKE-IMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 + K+P RLG ++ + I++H FF I W + +++ PPF+P++ S D FD Sbjct: 257 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP 316 Query: 441 EFTAQMITITPPDQ 454 +F + +TP D+ Sbjct: 317 DFIKEEPVLTPIDE 330 >3HDN-A nrPDB Length = 373 Score = 328 bits (840), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 165/331 (49%), Positives = 222/331 (67%), Gaps = 5/331 (1%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE-NRVLQNSR 206 ++F +LK++GKG+FGKV+L + KA +YA+K+L+K+ I+ K E H ++E N +L+N + Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 97 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HPFL L +SFQT D+L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS Sbjct: 98 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 157 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 N+VYRDLK EN++LD GHI +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y Sbjct: 158 -LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY 216 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 R VDWW LG V+YEM+ G PFY+++ ++++ IL + ++ + A+ LL GLL+K Sbjct: 217 DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQK 276 Query: 387 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQM 446 D +RL G +D EI H FF+ I W + KK++PPF P V+ D R+FD EFT + Sbjct: 277 DRTKRL-GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEP 335 Query: 447 ITITPPDQDDSMECVDS--ERRPHFPQFSYS 475 + DS+ S E F FSY+ Sbjct: 336 VPNAIGKAPDSVLVTASVKEAAEAFLGFSYA 366 >3PFQ-A nrPDB Length = 674 Score = 316 bits (809), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 166/395 (42%), Positives = 238/395 (60%), Gaps = 21/395 (5%) Query: 88 FHVETPEE----REEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKH 143 F+V P E EE + G + EE + S DN+G + Sbjct: 287 FNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRD---------- 336 Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E RVL Sbjct: 337 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 396 Query: 204 -NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI L Sbjct: 397 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE++ Sbjct: 457 FLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 515 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++ G Sbjct: 516 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 575 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442 L+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ + + FD F Sbjct: 576 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGR-NAENFDRFF 634 Query: 443 TAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477 T +TPPDQ E + + + F FS+ S Sbjct: 635 TRHPPVLTPPDQ----EVIRNIDQSEFEGFSFVNS 665 >3A8W-A nrPDB Length = 345 Score = 314 bits (805), Expect = 5e-86, Method: Compositional matrix adjust. Identities = 152/322 (47%), Positives = 216/322 (67%), Gaps = 12/322 (3%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-Q 203 + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++ +++ TE V Q Sbjct: 6 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 65 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 S HPFL L FQT RL FV+EY NGG+L FH+ R+R E+ ARFY AEI AL+Y Sbjct: 66 ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNY 125 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T TFCGTP Y+APE+L Sbjct: 126 LH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 184 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPF------YNQDH---EKLFELILMEEIRFPRTLGP 374 DYG +VDWW LGV+M+EMM GR PF N D + LF++IL ++IR PR+L Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSV 244 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSET 433 +A S+L L KDPK+RLG + +I H FF + W + +K++ PPFKP ++ E Sbjct: 245 KAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEF 304 Query: 434 DTRYFDEEFTAQMITITPPDQD 455 FD +FT + + +TP D D Sbjct: 305 GLDNFDSQFTNEPVQLTPDDDD 326 >2I0E-A nrPDB Length = 353 Score = 313 bits (801), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 153/337 (45%), Positives = 219/337 (64%), Gaps = 7/337 (2%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E RV Sbjct: 14 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 73 Query: 202 LQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 L + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI Sbjct: 74 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 133 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE+ Sbjct: 134 LFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 192 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 + YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++ Sbjct: 193 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 252 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 GL+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ + FD Sbjct: 253 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDR 311 Query: 441 EFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477 FT +TPPDQ E + + + F FS+ S Sbjct: 312 FFTRHPPVLTPPDQ----EVIRNIDQSEFEGFSFVNS 344 >4RA4-A nrPDB Length = 355 Score = 312 bits (800), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 148/312 (47%), Positives = 213/312 (68%), Gaps = 3/312 (0%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 RV + +F +L +LGKG+FGKV+L K T YA+KILKK+V++ D+V T+ E RVL Sbjct: 16 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 204 N-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + PFLT L FQT DRL FVMEY NGG+L +H+ + F E +A FY AEI L Sbjct: 76 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 135 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 +LH ++ ++YRDLKL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++ Sbjct: 136 FLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 194 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P++L EA S+ G Sbjct: 195 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKG 254 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442 L+ K P +RLG G E +++ +H FF I W+ + +++ PPFKP+V+ + FD+ F Sbjct: 255 LMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKG-AENFDKFF 313 Query: 443 TAQMITITPPDQ 454 T +TPPDQ Sbjct: 314 TRGQPVLTPPDQ 325 >4L42-A nrPDB Length = 346 Score = 299 bits (765), Expect = 2e-81, Method: Compositional matrix adjust. Identities = 159/347 (45%), Positives = 215/347 (61%), Gaps = 12/347 (3%) Query: 135 EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIV--AK 189 E S+ + ++ FE L++LGKG +GKV V++ TG+ +AMK+LKK +IV AK Sbjct: 5 ETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 64 Query: 190 DEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249 D AHT E +L+ +HPF+ L Y+FQT +L ++EY +GGELF L RE +F ED Sbjct: 65 D-TAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDT 123 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309 A FY AEI AL +LH +K ++YRDLK EN+ML+ GH+K+TDFGLCKE I DG TF Sbjct: 124 ACFYLAEISMALGHLH-QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTF 182 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369 CGT EY+APE+L + + RAVDWW LG +MY+M+ G PF ++ +K + IL ++ P Sbjct: 183 CGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLP 242 Query: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV 429 L EA+ LL LLK++ RLG G DA E+ H FF I W+ + +K+ PPFKP + Sbjct: 243 PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLL 302 Query: 430 TSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476 SE D FD +FT Q TP D D + E + F F Y A Sbjct: 303 QSEEDVSQFDSKFTRQ----TPVDSPDD-STLSEEEQEMFRDFEYIA 344 >4OTD-A nrPDB Length = 341 Score = 295 bits (756), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 155/341 (45%), Positives = 224/341 (65%), Gaps = 8/341 (2%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K +T+ +F++L +LG+G FGKV+L + + +G +A+K LKK IVA+DEV + E R+ Sbjct: 6 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 65 Query: 202 LQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 L ++ HPFL L FQT + +CFVMEY+ GG+L H+ + VFSE RA FY A +V Sbjct: 66 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVV 124 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 L +LH E +VYRDLKL+NL+LD +G++KI DFGLCKEG+ G TFCGTPE+LAP Sbjct: 125 LGLQFLH-EHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378 EVL D Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +E+R+PR L EA Sbjct: 184 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 243 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438 ++ LL+++P++RLG DA+++ + FF + W+ + ++L PPF P ++ TD F Sbjct: 244 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 303 Query: 439 DEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGT 479 DEEFT + T++PP + + + F F + A G Sbjct: 304 DEEFTGEAPTLSPPRDARPLTAAE---QAAFLDFDFVAGGC 341 >5F9E-A nrPDB Length = 353 Score = 292 bits (747), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 150/336 (44%), Positives = 213/336 (63%), Gaps = 10/336 (2%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 ++ + +FE K+LGKG+FGKV L + K T +++A+K LKK+V++ D+V T+ E RVL Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 204 NS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + HPFLT + +FQT + L FVMEY NGG+L +H+ F RA FY AEI+ L Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 +LHS K +VYRDLKL+N++LDKDGHIKI DFG+CKE + A FCGTP+Y+APE+L Sbjct: 135 FLHS-KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 Y +VDWW GV++YEM+ G+ PF+ QD E+LF I M+ +PR L EAK LL Sbjct: 194 GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVK 253 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442 L ++P++RLG +I QH F I W+ + K++ PPF+P+V S D FD+EF Sbjct: 254 LFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 309 Query: 443 TAQMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478 + ++ D+ ++S + F FS+ G Sbjct: 310 LNEKPRLSFADR----ALINSMDQNMFRNFSFMNPG 341 >4CRS-A nrPDB Length = 341 Score = 291 bits (746), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 157/343 (45%), Positives = 222/343 (64%), Gaps = 8/343 (2%) Query: 137 SLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 196 S+++ + + + +F +L +G FGKV+L + K T +A+K LKK IVA+DEV + Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 60 Query: 197 TENRVLQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253 E R+ + + RHPFL L FQT + +CFVMEYA GG+L H+ + VFSE RA FY Sbjct: 61 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFY 119 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP 313 A +V L YLH E +VYRDLKL+NL+LD +G +KI DFGLCKEG+ G TFCGTP Sbjct: 120 AACVVLGLQYLH-EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP 178 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLG 373 E+LAPEVL + Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +E+R+PR L Sbjct: 179 EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS 238 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSET 433 EA S++ LL+++P++RLG +DA+++ +H FF I W + +KK+ PPF P + Sbjct: 239 TEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGRE 298 Query: 434 DTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476 D FD+EFT++ +TPP + + E + F F Y A Sbjct: 299 DVSNFDDEFTSEAPILTPPREP---RILSEEEQEMFRDFDYIA 338 >5D9K-A nrPDB Length = 330 Score = 281 bits (720), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 139/302 (46%), Positives = 200/302 (66%), Gaps = 7/302 (2%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATG----RYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 ++FE LK+LG+G+FGKV LVK K +G + YAMK+LKK + +D V T E +L Sbjct: 30 SQFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILV 87 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ ALD+ Sbjct: 88 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 147 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LHS ++YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APEV+ Sbjct: 148 LHS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNR 206 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 + ++ DWW GV+M+EM+ G LPF +D ++ +IL ++ P+ L PEA+SLL L Sbjct: 207 RGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRML 266 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 443 K++P RLG G + +EI +H FF+ I W +Y +++ PPFKP DT YFD EFT Sbjct: 267 FKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFT 326 Query: 444 AQ 445 A+ Sbjct: 327 AK 328 >4RLP-A nrPDB Length = 288 Score = 277 bits (708), Expect = 9e-75, Method: Compositional matrix adjust. Identities = 140/283 (49%), Positives = 188/283 (66%), Gaps = 7/283 (2%) Query: 150 FEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIV--AKDEVAHTLTENRVLQN 204 FE L++LGKG +GKV V++ TG+ +AMK+LKK +IV AKD AHT E +L+ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKD-TAHTKAERNILEE 65 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 +HPF+ L Y+FQT +L ++EY +GGELF L RE +F ED A FY AEI AL +L Sbjct: 66 VKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHL 125 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 H +K ++YRDLK EN+ML+ GH+K+TDFGLCKE I DG TFCGT EY+APE+L + Sbjct: 126 H-QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 184 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384 + RAVDWW LG +MY+M+ G PF ++ +K + IL ++ P L EA+ LL LL Sbjct: 185 GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLL 244 Query: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427 K++ RLG G DA E+ H FF I W+ + +K+ PPFKP Sbjct: 245 KRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >2Z7Q-A nrPDB Length = 321 Score = 275 bits (703), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 136/304 (44%), Positives = 195/304 (64%), Gaps = 11/304 (3%) Query: 139 AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVAHT 195 A P H FE LK+LG+G+FGKV LV++ +G YAMK+LKK + +D V T Sbjct: 25 ADPSH------FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RT 77 Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 E +L + HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY A Sbjct: 78 KMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 137 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEY 315 E+ LD+LHS ++YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY Sbjct: 138 ELALGLDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEY 196 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE 375 +APEV+ + + DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L E Sbjct: 197 MAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTE 256 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDT 435 A+SLL L K++P RLG G + A+EI +H F++ I W +Y +++ PPFKP V DT Sbjct: 257 AQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDT 316 Query: 436 RYFD 439 YFD Sbjct: 317 FYFD 320 >4WB7-A nrPDB Length = 405 Score = 267 bits (683), Expect = 6e-72, Method: Compositional matrix adjust. Identities = 133/294 (45%), Positives = 186/294 (63%), Gaps = 4/294 (1%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 +++FE +K LG G+FG+V+LVK K TG +YAMKIL K+ +V ++ HTL E R+LQ Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 154 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 PFL L++SF+ + L VMEY GGE+F HL R FSE ARFY A+IV +YLHS Sbjct: 155 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 214 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +++YRDLK ENL++D+ G+I++TDFG K G T T CGTPEYLAPE++ Y Sbjct: 215 -LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGY 270 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 +AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL LL+ Sbjct: 271 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 330 Query: 387 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 D +R G +I H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 331 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 384 >5X3F-B nrPDB Length = 393 Score = 267 bits (682), Expect = 9e-72, Method: Compositional matrix adjust. Identities = 131/299 (43%), Positives = 188/299 (62%), Gaps = 4/299 (1%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 ++ +++F+ +K LG G+FG+V+LVK K +G +YAMKIL K+ +V ++ HTL E R+ Sbjct: 78 QNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRI 137 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 LQ PFL L++SF+ + L VMEY GGE+F HL R FSE ARFY A+IV Sbjct: 138 LQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 197 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +YLHS +++YRDLK ENL++D+ G+I++TDFG K G T T CGTPEYLAPE++ Sbjct: 198 EYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEII 253 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 Y +AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL Sbjct: 254 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 313 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 LL+ D +R G +I H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 314 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 372 >5N23-A nrPDB Length = 352 Score = 267 bits (682), Expect = 9e-72, Method: Compositional matrix adjust. Identities = 131/294 (44%), Positives = 185/294 (62%), Gaps = 3/294 (1%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 +++FE ++ LG G+FG+V+LVK K TG +YAMKIL K+ +V ++ HTL E R+ Q Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVN 100 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 PFL L++SF+ + L V+EYA GGE+F HL R FSE ARFY A+IV +YLHS Sbjct: 101 FPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +++YRDLK ENL++D+ G+IK+ DFG K G T T CGTPEYLAPE++ Y Sbjct: 161 -LDLIYRDLKPENLLIDQQGYIKVADFGFAKR--VKGRTPWTLCGTPEYLAPEIILSKGY 217 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 +AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL LL+ Sbjct: 218 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 277 Query: 387 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 D +R G +I H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 278 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 331 >2UVM-A nrPDB Length = 123 Score = 261 bits (668), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 123/123 (100%), Positives = 123/123 (100%) Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60 Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120 Query: 121 RSG 123 RSG Sbjct: 121 RSG 123 >1VZO-A nrPDB Length = 355 Score = 257 bits (657), Expect = 7e-69, Method: Compositional matrix adjust. Identities = 143/315 (45%), Positives = 195/315 (61%), Gaps = 15/315 (4%) Query: 137 SLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVA 193 +L +V + FE LK+LG G +GKV LV++ + TG+ YAMK+LKK IV K + Sbjct: 43 NLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTT 102 Query: 194 -HTLTENRVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRAR 251 HT TE +VL++ R PFL L Y+FQT +L +++Y NGGELF HLS+ F+E + Sbjct: 103 EHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQ 162 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK-TFC 310 Y EIV AL++LH + ++YRD+KLEN++LD +GH+ +TDFGL KE + D FC Sbjct: 163 IYVGEIVLALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFC 221 Query: 311 GTPEYLAPEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK-----LFELILM 363 GT EY+AP+++ D G +AVDWW LGV+MYE++ G PF D EK + IL Sbjct: 222 GTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKNSQAEISRRILK 280 Query: 364 EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSP 423 E +P+ + AK L+ LL KDPK+RLG G DA EI +H FF I W + KK+ Sbjct: 281 SEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPA 340 Query: 424 PFKPQVTSETDTRYF 438 PFKP + E D F Sbjct: 341 PFKPVIRDELDVSNF 355 >1FOT-A nrPDB Length = 318 Score = 257 bits (656), Expect = 8e-69, Method: Compositional matrix adjust. Identities = 123/298 (41%), Positives = 189/298 (63%), Gaps = 5/298 (1%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 + ++ +F+ L+ LG G+FG+V L++ + GRYYAMK+LKKE++V +V HT E +L Sbjct: 2 KYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLS 61 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 HPF+ + +FQ ++ +M+Y GGELF L + + F A+FY AE+ AL+Y Sbjct: 62 IVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 121 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LHS K+++YRDLK EN++LDK+GHIKITDFG K + D T CGTP+Y+APEV+ Sbjct: 122 LHS-KDIIYRDLKPENILLDKNGHIKITDFGFAKY-VPD--VTYTLCGTPDYIAPEVVST 177 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 Y +++DWW G+++YEM+ G PFY+ + K +E IL E+RFP + K LLS L Sbjct: 178 KPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRL 237 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV-TSETDTRYFDE 440 + +D QRLG +++ H +F +VW+ + + + P++P + + DT FD+ Sbjct: 238 ITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDK 295 >6BDL-A nrPDB Length = 347 Score = 214 bits (545), Expect = 6e-56, Method: Compositional matrix adjust. Identities = 115/299 (38%), Positives = 174/299 (58%), Gaps = 5/299 (1%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKAT-GRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + +++F + LG G FG+V LV+ K+ + +AMKILKK IV + H +E +++ Sbjct: 30 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 89 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 Q + F+ L +F+ L +ME GGEL+ L F + RFY A +V A Sbjct: 90 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 149 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 YLHS K ++YRDLK ENL+LD G+ K+ DFG K+ I G TFCGTPEY+APE++ Sbjct: 150 YLHS-KGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIIL 207 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFPRTLGPEAKSLL 380 + + + D+W LG++MYE++ G PF D K + +IL ++ I FP+ + A +L+ Sbjct: 208 NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLI 267 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439 L + +P +RLG K+I +H++F G W+ + + L+PP P V S TDT FD Sbjct: 268 KKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD 326 >5LOH-A nrPDB Length = 341 Score = 212 bits (539), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 127/345 (36%), Positives = 195/345 (56%), Gaps = 23/345 (6%) Query: 118 MDFRSGS---PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR 174 MD +GS P + EE +A PK ++ EF +K + +G FGKV L ++ G+ Sbjct: 4 MDPTAGSKKEPGGGAATEEGVNRIAVPK-PPSIEEFSIVKPISRGAFGKVYLGQKG--GK 60 Query: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGE 234 YA+K++KK ++ K+ E L S+ PF+ L YS Q+ + + VMEY GG+ Sbjct: 61 LYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGD 120 Query: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 + L F E+ A Y +E+ ALDYLH +++RDLK +N+++ +GHIK+TDFG Sbjct: 121 VKSLLHIYGYFDEEMAVKYISEVALALDYLH-RHGIIHRDLKPDNMLISNEGHIKLTDFG 179 Query: 295 LCKEGIK------DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP 348 L K + D T +TFCGTP+YLAPE+L +G AVDWW LGV ++E + G P Sbjct: 180 LSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPP 239 Query: 349 FYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 F ++ +++F+ IL +I +P L A+S + LL D +R G KE+ +H Sbjct: 240 FNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAG-----MKELKRH 294 Query: 406 RFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITIT 450 F+ + W+++ + + PF PQ ETDT YF+ TAQ +T++ Sbjct: 295 PLFSDVDWENLQHQTM--PFIPQPDDETDTSYFEARNTAQHLTVS 337 >2X18-A nrPDB Length = 119 Score = 209 bits (533), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 98/119 (82%), Positives = 107/119 (89%), Gaps = 1/119 (0%) Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60 MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD PLNNFSVA+C Sbjct: 2 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 60 Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMD 119 QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+ Sbjct: 61 QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMN 119 >3NYO-A nrPDB Length = 576 Score = 208 bits (530), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 123/322 (38%), Positives = 186/322 (57%), Gaps = 10/322 (3%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E ++ Sbjct: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVS 259 L+ F+ +L Y+++T D LC V+ NGG+L FH+ + F E RA FY AEI Sbjct: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 L+ LH E+ +VYRDLK EN++LD GHI+I+D GL + +G T+K GT Y+APE Sbjct: 298 GLEDLHRER-IVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPE 355 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI--LMEEI--RFPRTLGPE 375 V+++ Y + DWW LG ++YEM+ G+ PF + + E + L++E+ + P+ Sbjct: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK--PQVTSET 433 A+SL S LL KDP +RLG A+E+ +H F + ++ + L PPFK PQ Sbjct: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCK 475 Query: 434 DTRYFDEEFTAQMITITPPDQD 455 D ++ T + + + P DQD Sbjct: 476 DVLDIEQFSTVKGVELEPTDQD 497 >4TNB-A nrPDB Length = 590 Score = 208 bits (529), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 118/289 (40%), Positives = 170/289 (58%), Gaps = 8/289 (2%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + + L E ++L+ Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262 F+ L Y+++T D LC V+ NGG+L FH+ F E+RA FY AEI+ L+ Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 LH E N VYRDLK EN++LD GHI+I+D GL + I +G ++ GT Y+APEVL Sbjct: 301 DLHHE-NTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPEAKS 378 + YG + D+WGLG ++YEM+ G+ PF + E++ +L E + EAKS Sbjct: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427 + LL KD KQRLG E+A E+ +H FF + ++ + L PPF P Sbjct: 419 ICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467 >5UUU-A nrPDB Length = 547 Score = 203 bits (517), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 117/323 (36%), Positives = 181/323 (56%), Gaps = 16/323 (4%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ- 203 +TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L Sbjct: 195 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 254 Query: 204 --NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI+ L Sbjct: 255 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 314 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+APEVL Sbjct: 315 EHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 371 Query: 322 EDN-DYGRAVDWWGLGVVMYEMMCGRLPFY---NQDHEKLFELILMEEIRFPRTLGPEAK 377 + Y + DW+ LG ++++++ G PF +D ++ + L + P + PE + Sbjct: 372 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 431 Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTSE 432 SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P Sbjct: 432 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 491 Query: 433 TDTRYFDEEFTAQMITITPPDQD 455 D FDEE T + I + DQ+ Sbjct: 492 FDIGSFDEEDT-KGIKLLDSDQE 513 >3PVW-A nrPDB Length = 695 Score = 203 bits (516), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 117/323 (36%), Positives = 181/323 (56%), Gaps = 16/323 (4%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ- 203 +TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L Sbjct: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 Query: 204 --NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI+ L Sbjct: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+APEVL Sbjct: 306 EHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 362 Query: 322 EDN-DYGRAVDWWGLGVVMYEMMCGRLPFYN---QDHEKLFELILMEEIRFPRTLGPEAK 377 + Y + DW+ LG ++++++ G PF +D ++ + L + P + PE + Sbjct: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTSE 432 SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P Sbjct: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 Query: 433 TDTRYFDEEFTAQMITITPPDQD 455 D FDEE T + I + DQ+ Sbjct: 483 FDIGSFDEEDT-KGIKLLDSDQE 504 >3TKU-A nrPDB Length = 433 Score = 201 bits (511), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 122/317 (38%), Positives = 182/317 (57%), Gaps = 19/317 (5%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 +FE +K++G+G FG+V +VK K T R YAMKIL K ++ + E A E VL N Sbjct: 91 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQ 150 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALDYLHSE 267 ++TAL Y+FQ + L VM+Y GG+L LS+ E ED ARFY E+V A+D +H + Sbjct: 151 WITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIH-Q 209 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GTPEYLAPEVLEDND- 325 + V+RD+K +N++LD +GHI++ DFG C + DG + GTP+Y++PE+L+ + Sbjct: 210 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 269 Query: 326 ----YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP-----RTLGPEA 376 YG DWW LGV MYEM+ G PFY + + + I+ E RF + EA Sbjct: 270 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 329 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 436 K L+ L+ ++ G ED K +H FF G+ W+++ + L P+ P V+S +DT Sbjct: 330 KDLIQRLICSRERRLGQNGIEDFK---KHAFFEGLNWENI--RNLEAPYIPDVSSPSDTS 384 Query: 437 YFD-EEFTAQMITITPP 452 FD ++ + I PP Sbjct: 385 NFDVDDDVLRNTEILPP 401 >5FET-A nrPDB Length = 847 Score = 197 bits (501), Expect = 8e-51, Method: Compositional matrix adjust. Identities = 115/320 (35%), Positives = 180/320 (56%), Gaps = 12/320 (3%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +V M+E E +++G+GTFG V LV K T YA+K + K I++ ++ + E + Sbjct: 529 KVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITA 588 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + HPF+ L +F+ + F+ E GGEL+ + + + S+ +A+FY I+ A++Y Sbjct: 589 ENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEY 648 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LH E+N+VYRDLK EN++LDK G++K+ DFG C + I+ A T GTP Y+APEV+ Sbjct: 649 LH-ERNIVYRDLKPENILLDKQGYVKLIDFG-CAKKIQGRAY--TLVGTPHYMAPEVILG 704 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYN--QDHEKLFELILMEEIRFPRTLGPE-AKSLL 380 YG VD W LGV +YE +CG LPF N +D ++F IL ++ FP + + + +L+ Sbjct: 705 KGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLM 764 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ---VTSETDTRY 437 LL + P+ R+G K+I +H FF W + + L PP + + D + Sbjct: 765 KRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQ 824 Query: 438 FDEEFTAQMITITPPDQDDS 457 +EE + P D DDS Sbjct: 825 IEEE--DALNEGEPLDGDDS 842 >4AW2-A nrPDB Length = 437 Score = 196 bits (497), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 122/324 (37%), Positives = 187/324 (57%), Gaps = 22/324 (6%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ +FE LK++G+G FG+V +VK K + +AMKIL K ++ + E A E VL Sbjct: 70 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV 129 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALD 262 N ++T L Y+FQ + L VM+Y GG+L LS+ E E+ ARFY AE+V A+D Sbjct: 130 NGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAID 189 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GTPEYLAPEVL 321 +H + + V+RD+K +N+++D +GHI++ DFG C + ++DG + GTP+Y++PE+L Sbjct: 190 SVH-QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 248 Query: 322 EDND-----YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFPRT--- 371 + + YG DWW LGV MYEM+ G PFY + + + I+ E +FP Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTD 308 Query: 372 LGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 430 + AK L+ L+ + RLG G ED K +H FF+GI W ++ + P+ P+V+ Sbjct: 309 VSENAKDLIRRLICSR-EHRLGQNGIEDFK---KHPFFSGIDWDNI--RNCEAPYIPEVS 362 Query: 431 SETDTRYF--DEEFTAQMITITPP 452 S TDT F D++ T+ PP Sbjct: 363 SPTDTSNFDVDDDCLKNSETMPPP 386 >3ORZ-A nrPDB Length = 316 Score = 194 bits (493), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 104/279 (37%), Positives = 167/279 (59%), Gaps = 6/279 (2%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 +F++ K+LG+G+F V+L +E AT R YA+KIL+K I+ +++V + E V+ HP Sbjct: 38 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHP 97 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 F L + FQ ++L F + YA GEL ++ + F E RFY AEIVSAL+YLH K Sbjct: 98 FFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHG-K 156 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG--ATMKTFCGTPEYLAPEVLEDNDY 326 +++RDLK EN++L++D HI+ITDFG K + A +F GT +Y++PE+L + Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 216 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 ++ D W LG ++Y+++ G PF + +F+ I+ E FP P+A+ L+ LL Sbjct: 217 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 276 Query: 387 DPKQRLGGGS-EDAKEIMQHRFFAGIVWQHVYEKKLSPP 424 D +RLG E + H FF + W++++++ +PP Sbjct: 277 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 313 >5DYK-A nrPDB Length = 853 Score = 193 bits (491), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 105/285 (36%), Positives = 165/285 (57%), Gaps = 7/285 (2%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +V M+E E +++G+GTFG V LV K T YA+K + K I+ ++ + E + Sbjct: 535 KVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITA 594 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + HPF+ L +F+ F+ E GGEL+ + + + S+ +A+FY I+ A++Y Sbjct: 595 ENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEY 654 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LH E+N+VYRDLK EN++LDK G++K+ DFG C + ++ A T GTP Y+APEV+ Sbjct: 655 LH-ERNIVYRDLKPENILLDKQGYVKLIDFG-CAKKVQGRAY--TLVGTPHYMAPEVILG 710 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYN--QDHEKLFELILMEEIRFPRTL-GPEAKSLL 380 YG VD W LG+ +YE +CG LPF N +D ++F IL ++ FP + ++ +L+ Sbjct: 711 KGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLM 770 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPF 425 LL + P+ R+G K+I H FF+ W + + L PP Sbjct: 771 KRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPL 815 >4YHJ-A nrPDB Length = 584 Score = 193 bits (490), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 113/292 (38%), Positives = 166/292 (56%), Gaps = 8/292 (2%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + VT N F + ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E R+ Sbjct: 179 RQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRI 238 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVS 259 L+ + F+ +L Y+++T D LC V+ NGG+L FH+ F E RA FY AE+ Sbjct: 239 LEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCC 298 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 L+ L E+ +VYRDLK EN++LD GHI+I+D GL E I +G ++ GT Y+APE Sbjct: 299 GLEDLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPE 356 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPE 375 V+ + Y + DWWGLG ++YEM+ G PF E++ + I + + + Sbjct: 357 VVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSED 416 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427 AKS+ LL K+P +RLG E A + QH F I ++ + L PPF P Sbjct: 417 AKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468 >6E9W-A nrPDB Length = 443 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 114/306 (37%), Positives = 171/306 (55%), Gaps = 14/306 (4%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ ++E +K++G+G FG+V LV+ K+T + YAMK+L K ++ + + A E ++ Sbjct: 98 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 157 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + P++ L Y+FQ L VMEY GG+L +S V E ARFY AE+V ALD Sbjct: 158 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAEVVLALDA 216 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT-MKTFCGTPEYLAPEVLE 322 +HS ++RD+K +N++LDK GH+K+ DFG C + K+G T GTP+Y++PEVL+ Sbjct: 217 IHS-MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 323 ----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFP--RTLGP 374 D YGR DWW +GV +YEM+ G PFY + I+ + FP + Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISK 335 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETD 434 EAK+L+ L D + RLG +EI +H FF W + P P ++S+ D Sbjct: 336 EAKNLICAFL-TDREVRLGRNG--VEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDID 392 Query: 435 TRYFDE 440 T FD+ Sbjct: 393 TSNFDD 398 >3C51-A nrPDB Length = 543 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 105/284 (36%), Positives = 167/284 (58%), Gaps = 11/284 (3%) Query: 153 LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 ++LG+G FG+V + KATG+ YA K L K+ + + + E ++L F+ + Sbjct: 190 FRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVS 249 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSR----ERVFSEDRARFYGAEIVSALDYLHSEK 268 L Y+F+T LC VM NGG++ +H+ F E RA FY A+IVS L++LH ++ Sbjct: 250 LAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLH-QR 308 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT-MKTFCGTPEYLAPEVLEDNDYG 327 N++YRDLK EN++LD DG+++I+D GL E +K G T K + GTP ++APE+L +Y Sbjct: 309 NIIYRDLKPENVLLDDDGNVRISDLGLAVE-LKAGQTKTKGYAGTPGFMAPELLLGEEYD 367 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 +VD++ LGV +YEM+ R PF + ++++L + +L + + +P P +K L Sbjct: 368 FSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEAL 427 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427 L+KDP++RLG + H F I W+ + L+PPF P Sbjct: 428 LQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVP 471 >4FR4-A nrPDB Length = 384 Score = 187 bits (474), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 101/289 (34%), Positives = 163/289 (56%), Gaps = 12/289 (4%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 V + FE L+ +GKG+FGKV +V++ T + YAMK + K+ V ++EV + E +++Q Sbjct: 12 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 71 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 HPFL L YSFQ + + V++ GG+L +HL + F E+ + + E+V ALDYL Sbjct: 72 LEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYL 131 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 +++ +++RD+K +N++LD+ GH+ ITDF + ++ + T GT Y+APE+ Sbjct: 132 QNQR-IIHRDMKPDNILLDEHGHVHITDFNIAAMLPRE-TQITTMAGTKPYMAPEMFSSR 189 Query: 325 D---YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPRTLGPEAKS 378 Y AVDWW LGV YE++ GR P++ + E++ E + +P E S Sbjct: 190 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVS 249 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427 LL LL+ +P QR S ++ + I W V++K+L P F P Sbjct: 250 LLKKLLEPNPDQRFSQLS----DVQNFPYMNDINWDAVFQKRLIPGFIP 294 >6ED6-A nrPDB Length = 415 Score = 184 bits (466), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 109/301 (36%), Positives = 171/301 (56%), Gaps = 14/301 (4%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 +++ +K++G+G FG+V LV+ KA+ + YAMK+L K ++ + + A E ++ + P Sbjct: 89 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 148 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 ++ L Y+FQ L VMEY GG+L +S V E A+FY AE+V ALD +HS Sbjct: 149 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVVLALDAIHS-M 206 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT-MKTFCGTPEYLAPEVLE----D 323 +++RD+K +N++LDK GH+K+ DFG C + + G T GTP+Y++PEVL+ D Sbjct: 207 GLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGD 266 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFPRT--LGPEAKSL 379 YGR DWW +GV +YEM+ G PFY + I+ + FP + AK+L Sbjct: 267 GFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNL 326 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439 + L D + RLG +EI QH FF W ++ + P P+++S+ D+ FD Sbjct: 327 ICAFL-TDREVRLGRNG--VEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFD 383 Query: 440 E 440 + Sbjct: 384 D 384 >4LQP-A nrPDB Length = 508 Score = 181 bits (458), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 117/357 (32%), Positives = 180/357 (50%), Gaps = 74/357 (20%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 +F +K++GKG FG+V LV++K TG+ YAMK L K + KD++AH E VL S P Sbjct: 103 DFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSP 162 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 ++ +L YSFQ L +ME+ GG+L L R ++F+ED RFY AE + A++ +H + Sbjct: 163 WVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIH-KL 221 Query: 269 NVVYRDLKLENLMLDKDGHIKITDF--------------------------GLCKEGIKD 302 ++R +K +N+++D GHIK++DF G+ K G + Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYN 281 Query: 303 GATMKTF-----------------------------------CGTPEYLAPEVLEDNDYG 327 T T GTP+Y+APE+ YG Sbjct: 282 ANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYG 341 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE--IRFPRT--LGPEAKSLLSGL 383 + DWW LG +MYE + G PF ++ ++ + I+ E ++FP + EA+ L+ L Sbjct: 342 QECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRRL 401 Query: 384 LKKDPKQRLG--GGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438 L QRLG GG A EI H FF G+ W + +++ P+ P+++S TDTR+F Sbjct: 402 LTH-ADQRLGRHGG---ADEIKSHPFFRGVDWNTI--RQVEAPYIPKLSSITDTRFF 452 >2VD5-A nrPDB Length = 412 Score = 179 bits (454), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 129/354 (36%), Positives = 184/354 (51%), Gaps = 26/354 (7%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ ++FE LK++G+G F +V +VK K TG+ YAMKI+ K ++ + EV+ E VL Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 116 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSAL 261 N ++T L ++FQ + L VMEY GG+L LS+ ER+ +E ARFY AEIV A+ Sbjct: 117 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE-MARFYLAEIVMAI 175 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GTPEYLAPEV 320 D +H V+RD+K +N++LD+ GHI++ DFG C + DG GTP+YL+PE+ Sbjct: 176 DSVH-RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEI 234 Query: 321 LEDNDYGRA-------VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM--EEIRFPRT 371 L+ G DWW LGV YEM G+ PFY + + I+ E + P Sbjct: 235 LQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLV 294 Query: 372 ---LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428 + EA+ + LL P+ RLG G A + H FF G+ W + + PPF P Sbjct: 295 DEGVPEEARDFIQRLLCP-PETRLGRGG--AGDFRTHPFFFGLDWDGLRDS--VPPFTPD 349 Query: 429 VTSETDTRYFD--EEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480 TDT FD E+ M++ D E + H P YS S A Sbjct: 350 FEGATDTCNFDLVEDGLTAMVSGGGETLSDIRE--GAPLGVHLPFVGYSYSCMA 401 >6BXI-A nrPDB Length = 333 Score = 177 bits (449), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 105/335 (31%), Positives = 177/335 (52%), Gaps = 43/335 (12%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ + +FE LK++G+G FG+V LV++K TG YAMKIL+K ++ K++V H E +L Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV 61 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + ++ + YSFQ L +ME+ GG++ L ++ +E+ +FY AE V A+D Sbjct: 62 EADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDS 121 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF-------------- 309 +H + ++RD+K +NL+LD GH+K++DFGLC G+K + + Sbjct: 122 IH-QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCT-GLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 310 ----------------------CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347 GTP+Y+APEV Y + DWW LGV+MYEM+ G Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYP 239 Query: 348 PFYNQDHEKLFELIL--MEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 PF ++ ++ ++ ++ E + FP + P ++ +L+ + G+ +EI + Sbjct: 240 PFCSETPQETYKKVMNWKETLTFPPEV-PISEKAKDLILRFCCEWEHRIGAPGVEEIKSN 298 Query: 406 RFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 FF G+ W+H+ E+ + ++ S DT FDE Sbjct: 299 SFFEGVDWEHIRERPAA--ISIEIKSIDDTSNFDE 331 >2JC6-A nrPDB Length = 334 Score = 167 bits (422), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 96/250 (38%), Positives = 147/250 (58%), Gaps = 13/250 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 FE+ + LG G F +V+L +EKATG+ +A+K + K+ + K+ + E VL+ +H Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE--SSIENEIAVLRKIKHEN 81 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + AL+ +++ + L VM+ +GGELF + + ++E A +++ A+ YLH Sbjct: 82 IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLH-RMG 140 Query: 270 VVYRDLKLENLML---DKDGHIKITDFGLCK-EGIKDGATMKTFCGTPEYLAPEVLEDND 325 +V+RDLK ENL+ D++ I I+DFGL K EG G M T CGTP Y+APEVL Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEG--KGDVMSTACGTPGYVAPEVLAQKP 198 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLS 381 Y +AVD W +GV+ Y ++CG PFY+++ KLFE IL E F + AK + Sbjct: 199 YSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIR 258 Query: 382 GLLKKDPKQR 391 L++KDP +R Sbjct: 259 NLMEKDPNKR 268 >4FG9-A nrPDB Length = 320 Score = 165 bits (418), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 97/269 (36%), Positives = 154/269 (57%), Gaps = 18/269 (6%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 +++ +LG G F +VIL ++K T + A+K + KE + K+ E VL +HP Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE--GSMENEIAVLHKIKHPN 77 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + AL +++ L +M+ +GGELF + + ++E A +++ A+ YLH + Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH-DLG 136 Query: 270 VVYRDLKLENLM---LDKDGHIKITDFGLCKEGIKD-GATMKTFCGTPEYLAPEVLEDND 325 +V+RDLK ENL+ LD+D I I+DFGL K ++D G+ + T CGTP Y+APEVL Sbjct: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLSK--MEDPGSVLSTACGTPGYVAPEVLAQKP 194 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLS 381 Y +AVD W +GV+ Y ++CG PFY+++ KLFE IL E F + AK + Sbjct: 195 YSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIR 254 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 L++KDP++R ++ +QH + AG Sbjct: 255 HLMEKDPEKRFT-----CEQALQHPWIAG 278 >3MN3-A nrPDB Length = 271 Score = 165 bits (417), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 100/263 (38%), Positives = 147/263 (55%), Gaps = 9/263 (3%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + ++ +K LG+G+FGKV L TG+ A+KI+ K+V+ D E L+ R Sbjct: 3 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR 62 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L ++ D + V+EYA G ELF ++ + SE AR + +I+SA++Y H Sbjct: 63 HPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 K +V+RDLK ENL+LD+ ++KI DFGL + DG +KT CG+P Y APEV+ Y Sbjct: 122 HK-IVHRDLKPENLLLDEHLNVKIADFGL-SNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 327 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 G VD W GV++Y M+C RLPF ++ LF+ I P+ L P A L+ +L Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLI 239 Query: 386 KDPKQRLGGGSEDAKEIMQHRFF 408 +P R+ EIMQ +F Sbjct: 240 VNPLNRIS-----IHEIMQDDWF 257 >4REW-A nrPDB Length = 540 Score = 161 bits (408), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 98/254 (38%), Positives = 138/254 (54%), Gaps = 8/254 (3%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG GTFGKV + K + TG A+KIL ++ I + D V E + L+ RHP + L Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 73 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 T + VMEY +GGELF ++ + E +R +I+S +DY H VV+RDL Sbjct: 74 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM-VVHRDL 132 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWG 334 K EN++LD + KI DFGL + DG ++T CG+P Y APEV+ Y G VD W Sbjct: 133 KPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 191 Query: 335 LGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGG 394 GV++Y ++CG LPF + LF+ I P+ L P SLL +L+ DP +R Sbjct: 192 SGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKR--- 248 Query: 395 GSEDAKEIMQHRFF 408 K+I +H +F Sbjct: 249 --ASIKDIREHEWF 260 >4CFH-A nrPDB Length = 493 Score = 161 bits (408), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 103/272 (37%), Positives = 145/272 (53%), Gaps = 10/272 (3%) Query: 140 KPKH--RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 K KH RV + + LG GTFGKV + K + TG A+KIL ++ I + D V Sbjct: 23 KQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 82 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257 E + L+ RHP + L T + VMEY +GGELF ++ + E +R +I Sbjct: 83 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQI 142 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 +S +DY H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y A Sbjct: 143 LSGVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAA 200 Query: 318 PEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA 376 PEV+ Y G VD W GV++Y ++CG LPF + LF+ I P+ L P Sbjct: 201 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 260 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 SLL +L+ DP +R K+I +H +F Sbjct: 261 ISLLKHMLQVDPMKR-----ATIKDIREHEWF 287 >5ES1-A nrPDB Length = 328 Score = 161 bits (407), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 93/252 (36%), Positives = 140/252 (55%), Gaps = 4/252 (1%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 P+ + + + L+ +GKG F KV L + TGR A+KI+ K + + E R Sbjct: 8 PEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLFREVR 66 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 +++ HP + L +T L VMEYA+ GE+F +L E AR +IVSA Sbjct: 67 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSA 126 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 + Y H +KN+V+RDLK ENL+LD + +IKI DFG E G+ + TFCG+P Y APE+ Sbjct: 127 VHYCH-QKNIVHRDLKAENLLLDAEANIKIADFGFSNE-FTLGSKLDTFCGSPPYAAPEL 184 Query: 321 LEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379 + Y G VD W LGV++Y ++ G LPF + ++L E +L + R P + + +S+ Sbjct: 185 FQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESI 244 Query: 380 LSGLLKKDPKQR 391 L L +P +R Sbjct: 245 LRRFLVLNPAKR 256 >4CZT-A nrPDB Length = 464 Score = 160 bits (406), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 84/252 (33%), Positives = 139/252 (55%), Gaps = 4/252 (1%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R + ++E + LG+GTF KV + G A+K++ KE ++ +A E ++ Sbjct: 7 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 66 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 +HP + + + ++ FV+E+ GGELF +S ED AR Y ++++A+DY Sbjct: 67 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 126 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPEVL 321 HS + V +RDLK ENL+LD +G +K++DFGL + +++ + T CGTP Y+APEV+ Sbjct: 127 CHS-RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 322 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 + Y G D W GV+++ +M G LPF + + L++ I E P AK L+ Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 245 Query: 381 SGLLKKDPKQRL 392 +L +P R+ Sbjct: 246 KRILDPNPATRI 257 >2QNJ-A nrPDB Length = 328 Score = 160 bits (405), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 94/246 (38%), Positives = 137/246 (55%), Gaps = 4/246 (1%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + + LK +GKG F KV L + TGR A+KI+ K + + E R+++ Sbjct: 11 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILN 69 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L +T L +MEYA+GGE+F +L E AR +IVSA+ Y H Sbjct: 70 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH- 128 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +K +V+RDLK ENL+LD D +IKI DFG E G + TFCG+P Y APE+ + Y Sbjct: 129 QKRIVHRDLKAENLLLDADMNIKIADFGFSNE-FTVGGKLDTFCGSPPYAAPELFQGKKY 187 Query: 327 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 G VD W LGV++Y ++ G LPF Q+ ++L E +L + R P + + ++LL L Sbjct: 188 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLV 247 Query: 386 KDPKQR 391 +P +R Sbjct: 248 LNPIKR 253 >4RED-A nrPDB Length = 351 Score = 159 bits (403), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 98/254 (38%), Positives = 138/254 (54%), Gaps = 8/254 (3%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG GTFGKV + K + TG A+KIL ++ I + D V E + L+ RHP + L Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 T + VMEY +GGELF ++ + E +R +I+S +DY H VV+RDL Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM-VVHRDL 140 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWG 334 K EN++LD + KI DFGL + DG ++T CG+P Y APEV+ Y G VD W Sbjct: 141 KPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 335 LGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGG 394 GV++Y ++CG LPF + LF+ I P+ L P SLL +L+ DP +R Sbjct: 200 SGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKR--- 256 Query: 395 GSEDAKEIMQHRFF 408 K+I +H +F Sbjct: 257 --ASIKDIREHEWF 268 >5KZ7-A nrPDB Length = 346 Score = 159 bits (402), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 94/246 (38%), Positives = 138/246 (56%), Gaps = 4/246 (1%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + + LK +GKG F KV L + TG+ A+KI+ K + + + E R+++ Sbjct: 32 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS-SSLQKLFREVRIMKVLN 90 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L +T L VMEYA+GGE+F +L E AR +IVSA+ Y H Sbjct: 91 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH- 149 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +K +V+RDLK ENL+LD D +IKI DFG E G + TFCG+P Y APE+ + Y Sbjct: 150 QKFIVHRDLKAENLLLDADMNIKIADFGFSNE-FTFGNKLDTFCGSPPYAAPELFQGKKY 208 Query: 327 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 G VD W LGV++Y ++ G LPF Q+ ++L E +L + R P + + ++LL L Sbjct: 209 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 268 Query: 386 KDPKQR 391 +P +R Sbjct: 269 LNPSKR 274 >4CFF-A nrPDB Length = 571 Score = 158 bits (400), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 102/272 (37%), Positives = 144/272 (52%), Gaps = 10/272 (3%) Query: 140 KPKH--RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 K KH RV + + LG GTFGKV + + + TG A+KIL ++ I + D V Sbjct: 23 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 82 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257 E + L+ RHP + L T VMEY +GGELF ++ + E AR +I Sbjct: 83 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 142 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 +SA+DY H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y A Sbjct: 143 LSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAA 200 Query: 318 PEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA 376 PEV+ Y G VD W GV++Y ++CG LPF ++ LF+ I P L Sbjct: 201 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 260 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +LL +L+ DP +R K+I +H +F Sbjct: 261 ATLLMHMLQVDPLKR-----ATIKDIREHEWF 287 >5EZV-A nrPDB Length = 560 Score = 158 bits (400), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 102/272 (37%), Positives = 144/272 (52%), Gaps = 10/272 (3%) Query: 140 KPKH--RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 K KH RV + + LG GTFGKV + + + TG A+KIL ++ I + D V Sbjct: 18 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 77 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257 E + L+ RHP + L T VMEY +GGELF ++ + E AR +I Sbjct: 78 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 137 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 +SA+DY H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y A Sbjct: 138 LSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAA 195 Query: 318 PEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA 376 PEV+ Y G VD W GV++Y ++CG LPF ++ LF+ I P L Sbjct: 196 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 255 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +LL +L+ DP +R K+I +H +F Sbjct: 256 ATLLMHMLQVDPLKR-----ATIKDIREHEWF 282 >4C0T-A nrPDB Length = 974 Score = 157 bits (398), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 90/278 (32%), Positives = 147/278 (52%), Gaps = 16/278 (5%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R + +F++ K LG+G++ VIL +K TG+ YA+K+L K I+ + +V + E L Sbjct: 262 RRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALN 321 Query: 204 N-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 S + +L ++FQ D L FV++YA+ GEL + R +E+ R +GA+I+ A+ Sbjct: 322 RLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK---------EGIKDGATMKTFCGTP 313 Y+H + V++RDLK EN++LD I+ITDFG + E K+F GT Sbjct: 382 YMH-DNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTA 440 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLG 373 EY++PE+LE+ G+ D W G ++Y+M+ G+ PF + F+ I + F Sbjct: 441 EYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFP 500 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 + L+ +L P +R EI +H FF + Sbjct: 501 TIIRDLIKKILVLQPSRRAT-----IPEIQKHYFFQSV 533 >2JAM-A nrPDB Length = 304 Score = 157 bits (398), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 92/249 (36%), Positives = 140/249 (56%), Gaps = 13/249 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F ++++LG G F +V LVK++ TG+ +A+K +KK + + E VL+ +H Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLEN---EIAVLKKIKHEN 67 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L+ +++ VM+ +GGELF + V++E A +++SA+ YLH E Sbjct: 68 IVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLH-ENG 126 Query: 270 VVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +V+RDLK ENL+ +++ I ITDFGL K ++ M T CGTP Y+APEVL Y Sbjct: 127 IVHRDLKPENLLYLTPEENSKIMITDFGLSK--MEQNGIMSTACGTPGYVAPEVLAQKPY 184 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI----LMEEIRFPRTLGPEAKSLLSG 382 +AVD W +GV+ Y ++CG PFY + KLFE I E F + AK + Sbjct: 185 SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICH 244 Query: 383 LLKKDPKQR 391 LL+KDP +R Sbjct: 245 LLEKDPNER 253 >2YZA-A nrPDB Length = 276 Score = 153 bits (387), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 99/271 (36%), Positives = 142/271 (52%), Gaps = 8/271 (2%) Query: 139 AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 +K RV + + LG GTFGKV + + + TG A+KIL ++ I + D V E Sbjct: 2 SKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 61 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 + L+ RHP + L T VMEY +GGELF ++ + E AR +I+ Sbjct: 62 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQIL 121 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 SA+DY H VV+RDLK EN++LD + KI DFGL + DG ++ CG+P Y AP Sbjct: 122 SAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRDSCGSPNYAAP 179 Query: 319 EVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAK 377 EV+ Y G VD W GV++Y ++CG LPF ++ LF+ I P L Sbjct: 180 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVA 239 Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +LL +L+ DP +R K+I +H +F Sbjct: 240 TLLMHMLQVDPLKR-----ATIKDIREHEWF 265 >3H4J-B nrPDB Length = 336 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 90/238 (37%), Positives = 135/238 (56%), Gaps = 4/238 (1%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG+G+FGKV L T + A+K + ++++ D E L+ RHP + L Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYD 76 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 T + V+EYA GGELF ++ ++ +ED R + +I+ A++Y H K +V+RDL Sbjct: 77 VITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHK-IVHRDL 134 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWG 334 K ENL+LD + ++KI DFGL + DG +KT CG+P Y APEV+ Y G VD W Sbjct: 135 KPENLLLDDNLNVKIADFGL-SNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWS 193 Query: 335 LGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 G+V+Y M+ GRLPF ++ LF+ + P L P A+SL+ ++ DP QR+ Sbjct: 194 CGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRMIVADPMQRI 251 >4D28-A nrPDB Length = 446 Score = 152 bits (384), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 87/250 (34%), Positives = 135/250 (54%), Gaps = 8/250 (3%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + ++E + +G+GTF KV + TG A+KI+ K I+ V E +++ R Sbjct: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L + ++ V+E+ GGELF + + ED +R Y ++V A+ + HS Sbjct: 68 HPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHS 127 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLC---KEGIKDGATMKTFCGTPEYLAPEVLED 323 K V +RDLK ENL+LD +G++K++DFGL +EG++ + CGTP Y+APEVL Sbjct: 128 -KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVE---LLNDTCGTPNYVAPEVLSG 183 Query: 324 NDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 Y G A D W GV+++ ++ G LPF D L+ I E P E K L+ Sbjct: 184 QGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIHR 243 Query: 383 LLKKDPKQRL 392 +L +PK R+ Sbjct: 244 ILDPNPKTRI 253 >2HAK-A nrPDB Length = 328 Score = 150 bits (379), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 106/284 (37%), Positives = 155/284 (54%), Gaps = 17/284 (5%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + + K +GKG F KV L + TGR A+KI+ K + + E R+++ Sbjct: 14 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILN 72 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L +T L VMEYA+GGE+F +L E AR +IVSA+ Y H Sbjct: 73 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH- 131 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +K +V+RDLK ENL+LD D +IKI DFG E G + TFCG+P Y APE+ + Y Sbjct: 132 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNE-FTVGNKLDTFCGSPPYAAPELFQGKKY 190 Query: 327 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 G VD W LGV++Y ++ G LPF Q+ ++L E +L + R P + + ++LL LL Sbjct: 191 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLV 250 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHV--YEKKLSPPFKP 427 +P +R GS ++IM+ R W +V E++L P +P Sbjct: 251 LNPIKR---GS--LEQIMKDR------WMNVGHEEEELKPYTEP 283 >6C9D-A nrPDB Length = 459 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 105/284 (36%), Positives = 154/284 (54%), Gaps = 17/284 (5%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + + K +GKG F KV L + TGR A+KI+ K + + E R+++ Sbjct: 20 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILN 78 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L +T L VMEYA+GGE+F +L E AR +IVSA+ Y H Sbjct: 79 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH- 137 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +K +V+RDLK ENL+LD D +IKI DFG E G + FCG+P Y APE+ + Y Sbjct: 138 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNE-FTVGNKLDEFCGSPPYAAPELFQGKKY 196 Query: 327 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 G VD W LGV++Y ++ G LPF Q+ ++L E +L + R P + + ++LL LL Sbjct: 197 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLV 256 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHV--YEKKLSPPFKP 427 +P +R GS ++IM+ R W +V E++L P +P Sbjct: 257 LNPIKR---GS--LEQIMKDR------WMNVGHEEEELKPYTEP 289 >4B8L-A nrPDB Length = 286 Score = 149 bits (375), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 92/266 (34%), Positives = 141/266 (53%), Gaps = 10/266 (3%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 PK + T+++F+ + LGKG FG V L +EK A+K+L K + K+ V H L Sbjct: 8 PKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQL-EKEGVEHQLRREI 66 Query: 201 VLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 +Q+ RHP + + F R+ ++E+A GEL+ L + F E R+ + E+ Sbjct: 67 EIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELAD 126 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 AL Y H E+ V++RD+K ENL++ G +KI DFG +T CGT +YL PE Sbjct: 127 ALHYCH-ERKVIHRDIKPENLLMGYKGELKIADFGWSVHA--PSLRRRTMCGTLDYLPPE 183 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379 ++E + VD W GV+ YE + G PF + H + I+ +++FP L +K L Sbjct: 184 MIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDL 243 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQH 405 +S LL+ P QRL K +M+H Sbjct: 244 ISKLLRYHPPQRL-----PLKGVMEH 264 >4UZD-A nrPDB Length = 287 Score = 147 bits (371), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 92/251 (36%), Positives = 133/251 (52%), Gaps = 5/251 (1%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K + + +FE + LGKG FG V L +EK + A+K+L K + K V H L Sbjct: 2 KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQL-EKAGVEHQLRREVE 60 Query: 202 LQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 +Q+ RHP + L F R+ ++EYA G ++ L + F E R Y E+ +A Sbjct: 61 IQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANA 120 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 L Y HS K V++RD+K ENL+L G +KI DFG T T CGT +YL PE+ Sbjct: 121 LSYCHS-KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRT--TLCGTLDYLPPEM 177 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 +E + VD W LGV+ YE + G+ PF +++ ++ I E FP + A+ L+ Sbjct: 178 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 237 Query: 381 SGLLKKDPKQR 391 S LLK +P QR Sbjct: 238 SRLLKHNPSQR 248 >4CQG-A nrPDB Length = 331 Score = 147 bits (370), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 84/247 (34%), Positives = 141/247 (57%), Gaps = 7/247 (2%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 +E + +G G F KV L TG A+KI+ K + + ++ TE L++ RH Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALKSLRHQH 68 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L + +T +++ V+EY GGELF ++ + SE+ R +I+SA+ Y+HS+ Sbjct: 69 ICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQ-G 127 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKE--GIKDGATMKTFCGTPEYLAPEVLEDNDY- 326 +RDLK ENL+ D++ +K+ DFGLC + G KD ++ CG+ Y APE+++ Y Sbjct: 128 YAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKD-YHLQECCGSLAYAAPELIQGKSYL 186 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 G D W +G+++Y +MCG LPF + + L++ I+ + P+ L P + LL +L+ Sbjct: 187 GSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQV 246 Query: 387 DPKQRLG 393 DPK+R+ Sbjct: 247 DPKKRIS 253 >5IG1-A nrPDB Length = 344 Score = 146 bits (368), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 88/262 (33%), Positives = 144/262 (54%), Gaps = 15/262 (5%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 ++GKG F V K TG A+K++ + + + E+ E + + +H + +++ Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRS-SEINKIKREIGICSSLQHEHIVSMR 82 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 +F+ V EY +GGELF + + ++E A +I+SAL + HS KN+++RD Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHS-KNIIHRD 141 Query: 275 LKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVD 331 LK ENL+L D + +KITDFGL ++ G T F GTP YL+PEV+ Y AVD Sbjct: 142 LKPENLLLASKDPNAPVKITDFGLAVI-MEQGPTYFGFAGTPGYLSPEVIRRVPYDTAVD 200 Query: 332 WWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGLLKKD 387 W GV++Y ++ G PF+ +DH+KL+ I + FP ++ AK L+ +L+ + Sbjct: 201 VWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEPN 260 Query: 388 PKQRLGGGSEDAKEIMQHRFFA 409 PK+R +E++QH + A Sbjct: 261 PKRR-----PTVQELLQHPWIA 277 >4D2V-A nrPDB Length = 356 Score = 145 bits (365), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 86/246 (34%), Positives = 135/246 (54%), Gaps = 7/246 (2%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 +E + +G G F KV L TG A+KI+ K + ++ TE L+N RH Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL--GSDLPRIKTEIEALKNLRHQH 88 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L + +T +++ V+EY GGELF ++ + SE+ R +IVSA+ Y+HS+ Sbjct: 89 ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQ-G 147 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPEVLEDNDY- 326 +RDLK ENL+ D+ +K+ DFGLC +G KD ++ CG Y APE+++ Y Sbjct: 148 YAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKD-YHLQACCGALAYAAPELIQGKSYL 206 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 G D W +G+++Y +MCG LPF + L I+ + P+ L P + LL +L+ Sbjct: 207 GSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQV 266 Query: 387 DPKQRL 392 DPK+R+ Sbjct: 267 DPKKRI 272 >3D2K-A nrPDB Length = 272 Score = 144 bits (363), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 93/265 (35%), Positives = 138/265 (52%), Gaps = 10/265 (3%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K + T+ +F+ + LGKG FG V L +E+ + A+K+L K + K V H L Sbjct: 6 KRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQL-EKAGVEHQLRREVE 64 Query: 202 LQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 +Q+ RHP + L F R+ ++EYA G ++ L + F E R Y E+ +A Sbjct: 65 IQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANA 124 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 L Y HS K V++RD+K ENL+L +G +KI DFG T T CGT +YL PE+ Sbjct: 125 LSYCHS-KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRT--TLCGTLDYLPPEM 181 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 +E + VD W LGV+ YE + G PF +++ + I E FP + A+ L+ Sbjct: 182 IEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLI 241 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQH 405 S LLK + QRL E+++H Sbjct: 242 SRLLKHNASQRL-----TLAEVLEH 261 >2W4O-A nrPDB Length = 349 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 99/269 (36%), Positives = 139/269 (51%), Gaps = 20/269 (7%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 FE LG+G V K+K T + YA+K+LKK V + TE VL HP Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV-----DKKIVRTEIGVLLRLSHPN 109 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + LK F+T + V+E GGELF + + +SE A +I+ A+ YLH E Sbjct: 110 IIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLH-ENG 168 Query: 270 VVYRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +V+RDLK ENL+ D +KI DFGL K ++ MKT CGTP Y APE+L Y Sbjct: 169 IVHRDLKPENLLYATPAPDAPLKIADFGLSKI-VEHQVLMKTVCGTPGYCAPEILRGCAY 227 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEK-LFELILMEEIRFPRT----LGPEAKSLLS 381 G VD W +G++ Y ++CG PFY++ ++ +F IL E F + AK L+ Sbjct: 228 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 287 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 L+ DPK+RL + +QH + G Sbjct: 288 KLIVLDPKKRL-----TTFQALQHPWVTG 311 >5JZN-A nrPDB Length = 280 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 91/262 (34%), Positives = 136/262 (51%), Gaps = 21/262 (8%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 + +G G F V E++T R YA+KI+KK K+ + E +L+ +HP + L Sbjct: 25 RTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQN--EVSILRRVKHPNIVLL 82 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYR 273 L VME GG+LF ++ ++E A + SA+ YLHS N+V+R Sbjct: 83 IEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHS-LNIVHR 141 Query: 274 DLKLENLML----DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 D+K ENL++ D +K+ DFGL I DG + T CGTP Y+APE++ + YG Sbjct: 142 DIKPENLLVYEHQDGSKSLKLGDFGLAT--IVDGP-LYTVCGTPTYVAPEIIAETGYGLK 198 Query: 330 VDWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGL 383 VD W GV+ Y ++CG PF D E LF+ ILM ++ FP + AK L++ + Sbjct: 199 VDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMM 258 Query: 384 LKKDPKQRLGGGSEDAKEIMQH 405 L D QR A ++++H Sbjct: 259 LLVDVDQRF-----SAVQVLEH 275 >5FG8-A nrPDB Length = 285 Score = 141 bits (355), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 87/257 (33%), Positives = 136/257 (52%), Gaps = 14/257 (5%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LGKG F V +K+TG +A KI+ + + A+D E R+ + HP + L Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARD-FQKLEREARICRKLHHPNIVRLHD 80 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 S Q + V + GGELF + +SE A +I+ ++++ H + VV+RDL Sbjct: 81 SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH-QNGVVHRDL 139 Query: 276 KLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 332 K ENL+L K +K+ DFGL E D F GTP YL+PEVL+ YG++VD Sbjct: 140 KPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDI 199 Query: 333 WGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGLLKKDP 388 W GV++Y ++ G PF+++D +L+ I +P T+ PEAK+L++ +L +P Sbjct: 200 WACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNP 259 Query: 389 KQRLGGGSEDAKEIMQH 405 +R+ A E ++H Sbjct: 260 NKRI-----TAAEALKH 271 >5YKS-A nrPDB Length = 377 Score = 141 bits (355), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 98/324 (30%), Positives = 167/324 (51%), Gaps = 26/324 (8%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA--HTLTENRVLQNSRHPFLT 211 K LG+G F V L + TG A+K++ K + D +A H E R ++ +HP + Sbjct: 41 KTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL---DTLATGHLFQEVRCMKLVQHPNIV 97 Query: 212 ALKYSFQTHDRLCFVMEYANGGELF-FHLSRERVFSEDRARFYGAEIVSALDYLHSEKNV 270 L T +L ++E +GG++F + + E +ED A+ Y A+IV A+ Y H + +V Sbjct: 98 RLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH-KLHV 156 Query: 271 VYRDLKLENLML-DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GR 328 V+RDLK EN++ +K G +K+TDFG + + G + T CG+ Y APE+L ++Y Sbjct: 157 VHRDLKPENVVFFEKQGLVKLTDFGFSNK-FQPGKKLTTSCGSLAYSAPEILLGDEYDAP 215 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDP 388 AVD W LGV+++ ++CG+ PF + + +I+ + P + E K L++ +L++DP Sbjct: 216 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDP 275 Query: 389 KQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK---PQVTSETDTRYFDEEFTAQ 445 K+R +EI H + G+ SP K P V+ + + + Sbjct: 276 KRR-----ASLEEIENHPWLQGV--------DPSPATKYNIPLVSYKNLSEEEHNSIIQR 322 Query: 446 MITITPPDQDDSMECVDSERRPHF 469 M+ D+D +E +++ R H Sbjct: 323 MVLGDIADRDAIVEALETNRYNHI 346 >5WAX-A nrPDB Length = 310 Score = 140 bits (354), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 93/270 (34%), Positives = 139/270 (51%), Gaps = 20/270 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + +E ++ +G G FG L++ +A G+ A+K +++ + + V + +R L RH Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKI-DENVQREIINHRSL---RH 66 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + K T L VMEYA+GGELF + FSED ARF+ +++S + Y HS Sbjct: 67 PNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 268 KNVVYRDLKLENLMLDKDG--HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + V +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL + Sbjct: 127 Q-VCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKE 184 Query: 326 Y-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF----ELILMEEIRFPR--TLGPEAKS 378 Y G+ D W GV +Y M+ G PF + D K F + IL + P + PE + Sbjct: 185 YDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQD 244 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L+S + +P R+ EI H +F Sbjct: 245 LISRIFVANPATRI-----TIPEIRNHPWF 269 >3UC3-A nrPDB Length = 361 Score = 140 bits (353), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 90/270 (33%), Positives = 139/270 (51%), Gaps = 20/270 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++++K +G G FG L+++K T A+K +++ + + V + +R L RH Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAI-DENVQREIINHRSL---RH 75 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + K T L +MEYA+GGEL+ + FSED ARF+ +++S + Y HS Sbjct: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 Query: 268 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + + +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL + Sbjct: 136 Q-ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLRQE 193 Query: 326 Y-GRAVDWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFPRT--LGPEAKS 378 Y G+ D W GV +Y M+ G PF + +D+ K + IL + P + PE Sbjct: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCH 253 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L+S + DP R+ EI H +F Sbjct: 254 LISRIFVADPATRIS-----IPEIKTHSWF 278 >2BDW-A nrPDB Length = 362 Score = 140 bits (353), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 85/244 (34%), Positives = 128/244 (52%), Gaps = 10/244 (4%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LGKG F V K TG +A KI+ + + A+D E R+ + +HP + L Sbjct: 37 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARD-FQKLEREARICRKLQHPNIVRLHD 95 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 S Q V + GGELF + +SE A +I+ ++ Y HS +V+R+L Sbjct: 96 SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN-GIVHRNL 154 Query: 276 KLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 332 K ENL+L K +K+ DFGL E + D F GTP YL+PEVL+ + Y + VD Sbjct: 155 KPENLLLASKAKGAAVKLADFGLAIE-VNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDI 213 Query: 333 WGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGLLKKDP 388 W GV++Y ++ G PF+++D +L+ I +P T+ PEAKSL+ +L +P Sbjct: 214 WACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNP 273 Query: 389 KQRL 392 K+R+ Sbjct: 274 KKRI 277 >4AF3-A nrPDB Length = 292 Score = 140 bits (352), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 90/248 (36%), Positives = 136/248 (54%), Gaps = 5/248 (2%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT-ENRVLQN 204 T+++FE + LGKG FG V L +EK + A+K+L K I K+ V H L E + + Sbjct: 21 TIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQI-EKEGVEHQLRREIEIQAH 79 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 HP + L F R+ ++EYA GEL+ L + F E R E+ AL Y Sbjct: 80 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 139 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 H +K V++RD+K ENL+L G +KI DFG KT CGT +YL PE++E Sbjct: 140 HGKK-VIHRDIKPENLLLGLKGELKIADFGWSVHA--PSLRRKTMCGTLDYLPPEMIEGR 196 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384 + VD W +GV+ YE++ G PF + H + + I+ +++FP ++ A+ L+S LL Sbjct: 197 MHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLL 256 Query: 385 KKDPKQRL 392 + +P +RL Sbjct: 257 RHNPSERL 264 >3KK8-A nrPDB Length = 284 Score = 140 bits (352), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 85/244 (34%), Positives = 128/244 (52%), Gaps = 10/244 (4%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LGKG F V K TG +A KI+ + + A+D E R+ + +HP + L Sbjct: 14 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARD-FQKLEREARICRKLQHPNIVRLHD 72 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 S Q V + GGELF + +SE A +I+ ++ Y HS +V+R+L Sbjct: 73 SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHS-NGIVHRNL 131 Query: 276 KLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 332 K ENL+L K +K+ DFGL E + D F GTP YL+PEVL+ + Y + VD Sbjct: 132 KPENLLLASKAKGAAVKLADFGLAIE-VNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDI 190 Query: 333 WGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGLLKKDP 388 W GV++Y ++ G PF+++D +L+ I +P T+ PEAKSL+ +L +P Sbjct: 191 WACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNP 250 Query: 389 KQRL 392 K+R+ Sbjct: 251 KKRI 254 >4YNZ-A nrPDB Length = 342 Score = 139 bits (351), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 84/258 (32%), Positives = 142/258 (55%), Gaps = 9/258 (3%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 K LGKG G V L T + A+KI+ +E + ++ + E +L+ HP + L Sbjct: 16 KTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVLKL 74 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYR 273 ++ L V+E+ +GGELF +L ++ + AR + +I+SALD+ HS ++ +R Sbjct: 75 HDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH-SICHR 133 Query: 274 DLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDW 332 DLK ENL+LD+ +I+I DFG+ + D + ++T CG+P Y PEV+ Y GR D Sbjct: 134 DLKPENLLLDERNNIRIADFGMASLQVGD-SLLETSCGSPHYACPEVIRGEKYDGRKADV 192 Query: 333 WGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 W GV+++ ++ G LPF + + +L E + P + P+ +SLL G+++ D +RL Sbjct: 193 WSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRL 252 Query: 393 GGGSEDAKEIMQHRFFAG 410 + I +H ++ G Sbjct: 253 -----TLEHIQKHIWYIG 265 >4JXF-A nrPDB Length = 266 Score = 139 bits (349), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 81/262 (30%), Positives = 137/262 (52%), Gaps = 7/262 (2%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 +F+ LLGKG+F V + TG A+K++ K+ + V E ++ +HP Sbjct: 8 DFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHP 67 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHL-SRERVFSEDRARFYGAEIVSALDYLHSE 267 + L F+ + + V+E + GE+ +L +R + FSE+ AR + +I++ + YLHS Sbjct: 68 SILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSH 127 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +++RDL L NL+L ++ +IKI DFGL + T CGTP Y++PE+ + +G Sbjct: 128 -GILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHG 186 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKD 387 D W LG + Y ++ GR PF + +++ + P L EAK L+ LL+++ Sbjct: 187 LESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRN 246 Query: 388 PKQRLGGGSEDAKEIMQHRFFA 409 P RL S ++ H F + Sbjct: 247 PADRLSLSS-----VLDHPFMS 263 >3UDB-A nrPDB Length = 317 Score = 138 bits (348), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 92/270 (34%), Positives = 137/270 (50%), Gaps = 20/270 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + +E +K +G G FG L+++K A+K +++ + + V + +R L RH Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKI-DENVKREIINHRSL---RH 74 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + K T L VMEYA+GGELF + FSED ARF+ +++S + Y H+ Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 268 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + V +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL + Sbjct: 135 Q-VAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQP-KSAVGTPAYIAPEVLLKKE 192 Query: 326 Y-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF----ELILMEEIRFPR--TLGPEAKS 378 Y G+ D W GV +Y M+ G PF + + K F IL + P + PE + Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L+S + DP +R+ EI H +F Sbjct: 253 LISRIFVADPAKRIS-----IPEIRNHEWF 277 >2VN9-A nrPDB Length = 301 Score = 137 bits (346), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 87/265 (32%), Positives = 137/265 (51%), Gaps = 14/265 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +E++ + LGKG F V + TG+ YA KI+ + + A+D E R+ + +H Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH-QKLEREARICRLLKH 62 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L S V + GGELF + +SE A +I+ ++++ H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHL- 121 Query: 268 KNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 +V+RDLK ENL+L K +K+ DFGL E D F GTP YL+PEVL + Sbjct: 122 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 181 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLL 380 YG+ VD W GV++Y ++ G PF+++D +L++ I FP T+ PEAK L+ Sbjct: 182 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 241 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQH 405 + +L +P +R+ A E ++H Sbjct: 242 NKMLTINPAKRI-----TASEALKH 261 >4B6L-A nrPDB Length = 281 Score = 137 bits (346), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 79/259 (30%), Positives = 126/259 (48%), Gaps = 8/259 (3%) Query: 152 YLK--LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 YLK LLGKG F + + TG YA+K++ + + + L E + ++ +H Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + + F+ D + +E + L E R+Y +I+S L YLH ++ Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLH-QRG 129 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 +++RDLKL N + ++ +K+ DFGL KT CGTP Y+APEVL +G Sbjct: 130 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE 189 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPK 389 D W LG VMY ++CG PF D ++ + I P +L A+ LL+ +L+ P+ Sbjct: 190 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR 249 Query: 390 QRLGGGSEDAKEIMQHRFF 408 R +I++H FF Sbjct: 250 DR-----PSIDQILRHDFF 263 >5XZW-A nrPDB Length = 471 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 87/263 (33%), Positives = 143/263 (54%), Gaps = 35/263 (13%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKIL-KKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 +++G+G F V E+ TG+ +A+KI+ K++VI D V L VLQ HP + Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTREL---EVLQKLNHPRIVR 258 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272 LK ++ + VME+ +GG+L ++ ED R +I++A+ Y+HS + + Sbjct: 259 LKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS-MGISH 317 Query: 273 RDLKLENLMLDKDG--HIKITDFGLCK-EGIKDGATMKTFCGTPEYLAPEVL-------- 321 RDLK +N+++++D +KITDFGL K +G +G+ MKTFCGT Y+APEV+ Sbjct: 318 RDLKPDNILIEQDDPVLVKITDFGLAKVQG--NGSFMKTFCGTLAYVAPEVIRGKDTSVS 375 Query: 322 -----EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--------MEEIRF 368 E N+Y VD W +G ++Y ++ G LPF ++L++ I +++ R Sbjct: 376 PDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFR- 434 Query: 369 PRTLGPEAKSLLSGLLKKDPKQR 391 + EA+ + LL+ DP R Sbjct: 435 ---ISEEARDFIDSLLQVDPNNR 454 >3HZT-A nrPDB Length = 467 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 91/265 (34%), Positives = 136/265 (51%), Gaps = 15/265 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ +K LG G +G+V+L K+K TG A+KI+KK + L E VL+ H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L F+ VME GGELF + + FSE A +++S YLH + Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH-K 122 Query: 268 KNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 N+V+RDLK ENL+L+ +D IKI DFGL + G MK GT Y+APEVL Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAH-FEVGGKMKERLGTAYYIAPEVLR-K 180 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 Y D W GV++Y ++CG PF Q +++ + + + F + EAK L+ Sbjct: 181 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 240 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQH 405 +L +P +R+ A+E + H Sbjct: 241 KLMLTYEPSKRIS-----AEEALNH 260 >2OU7-A nrPDB Length = 335 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 80/256 (31%), Positives = 124/256 (48%), Gaps = 6/256 (2%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 LGKG F K + + T +A KI+ K +++ + E + ++ H + Sbjct: 48 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFH 107 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 F+ +D + V+E L R + +E AR+Y +IV YLH + V++RD Sbjct: 108 GFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNR-VIHRD 166 Query: 275 LKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 334 LKL NL L++D +KI DFGL + DG K CGTP Y+APEVL + VD W Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWS 226 Query: 335 LGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGG 394 +G +MY ++ G+ PF ++ + I E P+ + P A SL+ +L+ DP R Sbjct: 227 IGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR--- 283 Query: 395 GSEDAKEIMQHRFFAG 410 E++ FF Sbjct: 284 --PTINELLNDEFFTS 297 >3ZUT-A nrPDB Length = 362 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 91/270 (33%), Positives = 137/270 (50%), Gaps = 20/270 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + +E +K +G G FG L+++K + A+K +++ + + V + +R L RH Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKI-DENVKREIINHRSL---RH 74 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + K T L VMEYA+GGELF + FSED ARF+ +++S + Y H+ Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 Query: 268 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + V +RDLKLEN +LD +KI FG K + K+ GTP Y+APEVL + Sbjct: 135 Q-VCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKE 192 Query: 326 Y-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF----ELILMEEIRFPR--TLGPEAKS 378 Y G+ D W GV +Y M+ G PF + + K F IL + P + PE + Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRH 252 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L+S + DP +R+ EI H +F Sbjct: 253 LISRIFVADPAKRIS-----IPEIRNHEWF 277 >3DXN-A nrPDB Length = 287 Score = 135 bits (341), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 91/265 (34%), Positives = 136/265 (51%), Gaps = 15/265 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ +K LG G +G+V+L K+K TG A+KI+KK + L E VL+ H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L F+ VME GGELF + + FSE A +++S YLH + Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH-K 139 Query: 268 KNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 N+V+RDLK ENL+L+ +D IKI DFGL + G MK GT Y+APEVL Sbjct: 140 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAH-FEVGGKMKERLGTAYYIAPEVLR-K 197 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 Y D W GV++Y ++CG PF Q +++ + + + F + EAK L+ Sbjct: 198 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 257 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQH 405 +L +P +R+ A+E + H Sbjct: 258 KLMLTYEPSKRI-----SAEEALNH 277 >4J52-A nrPDB Length = 293 Score = 135 bits (341), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 80/256 (31%), Positives = 124/256 (48%), Gaps = 6/256 (2%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 LGKG F K + + T +A KI+ K +++ + E + ++ H + Sbjct: 21 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFH 80 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 F+ +D + V+E L R + +E AR+Y +IV YLH + V++RD Sbjct: 81 GFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNR-VIHRD 139 Query: 275 LKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 334 LKL NL L++D +KI DFGL + DG K CGTP Y+APEVL + VD W Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWS 199 Query: 335 LGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGG 394 +G +MY ++ G+ PF ++ + I E P+ + P A SL+ +L+ DP R Sbjct: 200 IGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR--- 256 Query: 395 GSEDAKEIMQHRFFAG 410 E++ FF Sbjct: 257 --PTINELLNDEFFTS 270 >2V7O-A nrPDB Length = 336 Score = 135 bits (339), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 82/252 (32%), Positives = 135/252 (53%), Gaps = 9/252 (3%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++++ + LGKG F V +K + YA KI+ + + A+D E R+ + +H Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDH-QKLEREARICRLLKH 89 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L S V + GGELF + +SE A +I+ +++++H + Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIH-Q 148 Query: 268 KNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 ++V+RDLK ENL+L K +K+ DFGL E + F GTP YL+PEVL + Sbjct: 149 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 208 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLL 380 YG+ VD W GV++Y ++ G PF+++D KL++ I FP T+ PEAK+L+ Sbjct: 209 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 268 Query: 381 SGLLKKDPKQRL 392 + +L +P +R+ Sbjct: 269 NQMLTINPAKRI 280 >4I6B-A nrPDB Length = 308 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 79/259 (30%), Positives = 130/259 (50%), Gaps = 12/259 (4%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA---KDEVAHTLTENRVLQNSRHPFL 210 K LGKG F K + + + YA KI+ + ++++ + +R+L H + Sbjct: 34 KTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILH---HKHV 90 Query: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNV 270 + F+ + + ++EY + + L +V +E R+Y +IVS L YLH E+ + Sbjct: 91 VQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLH-EQEI 149 Query: 271 VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330 ++RDLKL N +++ +K+ DFGL +T CGTP YL+PEVL +G Sbjct: 150 LHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGAES 209 Query: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQ 390 D W LG VMY M+ GR PF + ++ + I P +L AK L++ +L K+P+ Sbjct: 210 DIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPED 269 Query: 391 RLGGGSEDAKEIMQHRFFA 409 R +I++H FF Sbjct: 270 R-----PSLDDIIRHDFFT 283 >5U6Y-A nrPDB Length = 461 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 84/264 (31%), Positives = 132/264 (50%), Gaps = 9/264 (3%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 ++ + LGKG F V + G+ YA KI+ + + A+D E R+ + +HP Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 60 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L S + + GGELF + +SE A +I+ A+ + H + Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH-QMG 119 Query: 270 VVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 VV+RDLK ENL+L K +K+ DFGL E + F GTP YL+PEVL + Y Sbjct: 120 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY 179 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSG 382 G+ VD W GV++Y ++ G PF+++D +L++ I FP T+ PEAK L++ Sbjct: 180 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 239 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHR 406 +L +P +R+ + HR Sbjct: 240 MLTINPSKRITAAEALKHPWISHR 263 >3BHH-A nrPDB Length = 295 Score = 132 bits (333), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 88/265 (33%), Positives = 135/265 (50%), Gaps = 14/265 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +E++ + +GKG F V + TG YA KI+ + + A+D E R+ + +H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDH-QKLEREARICRLLKH 62 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 + L S V + GGELF + +SE A +I+ A+ + H + Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH-Q 121 Query: 268 KNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 VV+RDLK ENL+L K +K+ DFGL E D F GTP YL+PEVL Sbjct: 122 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKE 181 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLL 380 YG+ VD W GV++Y ++ G PF+++D KL++ I FP T+ PEAK+L+ Sbjct: 182 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 241 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQH 405 + +L +P +R+ A E ++H Sbjct: 242 NQMLTINPAKRI-----TAHEALKH 261 >2VZ6-A nrPDB Length = 313 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 84/264 (31%), Positives = 132/264 (50%), Gaps = 9/264 (3%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 ++ + LGKG F V + G+ YA KI+ + + A+D E R+ + +HP Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 82 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L S + + GGELF + +SE A +I+ A+ + H + Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH-QMG 141 Query: 270 VVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 VV+RDLK ENL+L K +K+ DFGL E + F GTP YL+PEVL + Y Sbjct: 142 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY 201 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSG 382 G+ VD W GV++Y ++ G PF+++D +L++ I FP T+ PEAK L++ Sbjct: 202 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 261 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHR 406 +L +P +R+ + HR Sbjct: 262 MLTINPSKRITAAEALKHPWISHR 285 >3DB8-A nrPDB Length = 317 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 79/265 (29%), Positives = 128/265 (48%), Gaps = 6/265 (2%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 TM + + LGKG F K + + T +A K++ K +++ + TE + ++ Sbjct: 40 TMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSL 99 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 +P + F+ D + V+E L R + +E AR++ + + + YLH Sbjct: 100 DNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLH 159 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + + V++RDLKL NL L+ D +KI DFGL + DG K CGTP Y+APEVL Sbjct: 160 NNR-VIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKG 218 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 + VD W LG ++Y ++ G+ PF ++ + I E PR + P A +L+ +L Sbjct: 219 HSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLH 278 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAG 410 DP R E++ FF Sbjct: 279 ADPTLR-----PSVAELLTDEFFTS 298 >6CMJ-A nrPDB Length = 321 Score = 132 bits (331), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 81/272 (29%), Positives = 140/272 (51%), Gaps = 17/272 (6%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIV-------- 187 VS+ + V ++++ +GKG++G V L + YYAMK+L K+ ++ Sbjct: 22 VSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQ 81 Query: 188 AKDEVAHTLTENRVLQNSRHPFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRERVF 245 + + E +L+ HP + L D L V E N G + + + Sbjct: 82 PRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM-EVPTLKPL 140 Query: 246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT 305 SED+ARFY +++ ++YLH +K +++RD+K NL++ +DGHIKI DFG+ E A Sbjct: 141 SEDQARFYFQDLIKGIEYLHYQK-IIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDAL 199 Query: 306 MKTFCGTPEYLAPEVLEDND---YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 362 + GTP ++APE L + G+A+D W +GV +Y + G+ PF ++ L I Sbjct: 200 LSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIK 259 Query: 363 MEEIRFPRT--LGPEAKSLLSGLLKKDPKQRL 392 + + FP + + K L++ +L K+P+ R+ Sbjct: 260 SQALEFPDQPDIAEDLKDLITRMLDKNPESRI 291 >4PDS-A nrPDB Length = 347 Score = 132 bits (331), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 85/263 (32%), Positives = 142/263 (53%), Gaps = 35/263 (13%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKIL-KKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 +++G+G F V E+ TG+ +++KI+ K++VI D V L VLQ HP + Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTREL---EVLQKLNHPRIVR 93 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272 LK ++ + VME+ +GG+L ++ ED R +I++A+ Y+HS + + Sbjct: 94 LKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS-MGISH 152 Query: 273 RDLKLENLMLDKDGH--IKITDFGLCK-EGIKDGATMKTFCGTPEYLAPEVL-------- 321 RDLK +N+++++D +KIT FGL K +G +G+ MKTFCGT Y+APEV+ Sbjct: 153 RDLKPDNILIEQDDPVLVKITAFGLAKVQG--NGSFMKTFCGTLAYVAPEVIRGKDTSVS 210 Query: 322 -----EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--------MEEIRF 368 E N+Y VD W +G ++Y ++ G LPF ++L++ I +++ R Sbjct: 211 PDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFR- 269 Query: 369 PRTLGPEAKSLLSGLLKKDPKQR 391 + EA+ + LL+ DP R Sbjct: 270 ---ISEEARDFIDSLLQVDPNNR 289 >3SOA-A nrPDB Length = 444 Score = 131 bits (330), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 83/265 (31%), Positives = 132/265 (49%), Gaps = 9/265 (3%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 E++ + LGKG F V + G+ YA I+ + + A+D E R+ + +HP Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDH-QKLEREARICRLLKHP 70 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 + L S + + GGELF + +SE A +I+ A+ + H + Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH-QM 129 Query: 269 NVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 VV+R+LK ENL+L K +K+ DFGL E + F GTP YL+PEVL + Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLS 381 YG+ VD W GV++Y ++ G PF+++D +L++ I FP T+ PEAK L++ Sbjct: 190 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 249 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHR 406 +L +P +R+ + HR Sbjct: 250 KMLTINPSKRITAAEALKHPWISHR 274 >4APC-A nrPDB Length = 350 Score = 131 bits (329), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 88/283 (31%), Positives = 146/283 (51%), Gaps = 19/283 (6%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +M ++ L+ +G+G+FGK ILVK GR Y +K + + +K E + E VL N Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSK-EREESRREVAVLANM 80 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER--VFSEDRARFYGAEIVSALDY 263 +HP + + SF+ + L VM+Y GG+LF ++ ++ +F ED+ + +I AL + Sbjct: 81 KHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKH 140 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 +H K +++RD+K +N+ L KDG +++ DFG+ + + GTP YL+PE+ E+ Sbjct: 141 VHDRK-ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICEN 199 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRT---LGPEAKSLL 380 Y D W LG V+YE+ + F + L I+ FP + +SL+ Sbjct: 200 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGS--FPPVSLHYSYDLRSLV 257 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSP 423 S L K++P+ R I++ F A + EK LSP Sbjct: 258 SQLFKRNPRDR-----PSVNSILEKGFIAKRI-----EKFLSP 290 >6FD3-A nrPDB Length = 300 Score = 130 bits (328), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 93/282 (32%), Positives = 144/282 (51%), Gaps = 30/282 (10%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL------KKEVIVAK 189 VS+ PK + T FE + G+G G V + ATG+ A+K + KKE+I+ Sbjct: 15 VSVGDPKKKYT--RFEKI---GQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELII-- 67 Query: 190 DEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249 E V++ +++P + S+ D L VMEY GG L + E E + Sbjct: 68 -------NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT-DVVTETCMDEGQ 119 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309 E + ALD+LHS + V++RD+K +N++L DG +K+TDFG C + + + T Sbjct: 120 IAAVCRECLQALDFLHSNQ-VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 178 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---EI 366 GTP ++APEV+ YG VD W LG++ EM+ G P+ N++ + LI E+ Sbjct: 179 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL 238 Query: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + P L + L+ L+ D +R GS AKE++QH F Sbjct: 239 QNPERLSAVFRDFLNRCLEMDVDRR---GS--AKELLQHPFL 275 >3Q53-A nrPDB Length = 306 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 91/282 (32%), Positives = 146/282 (51%), Gaps = 30/282 (10%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL------KKEVIVAK 189 VS+ PK + T FE + G+G G V + ATG+ A++ + KKE+I+ Sbjct: 14 VSVGDPKKKYT--RFEKI---GQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELII-- 66 Query: 190 DEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249 E V++ +++P + S+ D L VMEY GG L + E E + Sbjct: 67 -------NEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT-DVVTETCMDEGQ 118 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309 E + AL++LHS + V++RD+K +N++L DG +K+TDFG C + + + T Sbjct: 119 IAAVCRECLQALEFLHSNQ-VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 177 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---EI 366 GTP ++APEV+ YG VD W LG++ EM+ G P+ N++ + LI E+ Sbjct: 178 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPEL 237 Query: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + P L + L+ L+ D ++R GS AKE++QH+F Sbjct: 238 QNPEKLSAIFRDFLNRCLEMDVEKR---GS--AKELIQHQFL 274 >3KN6-A nrPDB Length = 325 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 87/255 (34%), Positives = 129/255 (50%), Gaps = 24/255 (9%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKK--EVIVAKDEVAHTLTENRVLQNSRHPFLT 211 K LG+G+F K + + +A+KI+ K E K+ A L E HP + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG-------HPNIV 69 Query: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 L F VME NGGELF + +++ FSE A + ++VSA+ ++H + VV Sbjct: 70 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVV 128 Query: 272 YRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 +RDLK ENL+ + + IKI DFG + D +KT C T Y APE+L N Y Sbjct: 129 HRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDE 188 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHE-------KLFELILMEEIRFP----RTLGPEAK 377 + D W LGV++Y M+ G++PF + D ++ + I + F + + EAK Sbjct: 189 SCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAK 248 Query: 378 SLLSGLLKKDPKQRL 392 L+ GLL DP +RL Sbjct: 249 DLIQGLLTVDPNKRL 263 >3F3Z-A nrPDB Length = 277 Score = 128 bits (322), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 86/260 (33%), Positives = 136/260 (52%), Gaps = 18/260 (6%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G+G++G+V + +K T A K + K + ++V E ++++ HP + L Sbjct: 17 IGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLDHPNIIRLYE 73 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 +F+ + + VME GGELF + +RVF E A +++SA+ Y H + NV +RDL Sbjct: 74 TFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCH-KLNVAHRDL 132 Query: 276 KLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 332 K EN + D +K+ DFGL K G M+T GTP Y++P+VLE YG D Sbjct: 133 KPENFLFLTDSPDSPLKLIDFGLAAR-FKPGKMMRTKVGTPYYVSPQVLE-GLYGPECDE 190 Query: 333 WGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGLLKKDP 388 W GV+MY ++CG PF ++ I FP + P+A+SL+ LL K P Sbjct: 191 WSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRRLLTKSP 250 Query: 389 KQRLGGGSEDAKEIMQHRFF 408 KQR+ + + ++H +F Sbjct: 251 KQRI-----TSLQALEHEWF 265 >2Y7J-A nrPDB Length = 365 Score = 128 bits (322), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 86/275 (31%), Positives = 146/275 (53%), Gaps = 33/275 (12%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAK------DEVAH-TLTENRVL-QNSR 206 ++G+G V +ATG +A+KI+ EV + +EV T E +L Q + Sbjct: 101 VIGRGVSSVVRRCVHRATGHEFAVKIM--EVTAERLSPEQLEEVREATRRETHILRQVAG 158 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L S+++ + V + GELF +L+ + SE R ++ A+ +LH+ Sbjct: 159 HPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHA 218 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN-- 324 N+V+RDLK EN++LD + I+++DFG ++ G ++ CGTP YLAPE+L+ + Sbjct: 219 -NNIVHRDLKPENILLDDNMQIRLSDFGFSCH-LEPGEKLRELCGTPGYLAPEILKCSMD 276 Query: 325 ----DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE----- 375 YG+ VD W GV+++ ++ G PF+++ + +I+ + +F PE Sbjct: 277 ETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFS---SPEWDDRS 333 Query: 376 --AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 K L+S LL+ DP+ RL A++ +QH FF Sbjct: 334 STVKDLISRLLQVDPEARLT-----AEQALQHPFF 363 >4MVF-A nrPDB Length = 506 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 82/243 (33%), Positives = 129/243 (53%), Gaps = 13/243 (5%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG+GT+G V +K T + YA+K KK+ + + E +++ HP + L Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIKEEKKDRL---KNINRFFQEIEIMKKLDHPNIVKLYE 121 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 +++ + + +ME +G ELF + F+E A +I SA+ YLHS N+V+RDL Sbjct: 122 TYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS-LNIVHRDL 180 Query: 276 KLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 332 K EN + +KD +KI DFGL K + G T GTP Y+AP+VL D Y + D Sbjct: 181 KPENFLFQSENKDSLLKIIDFGLSK-NLGTGEFTTTKAGTPYYVAPQVL-DGKYDKKCDI 238 Query: 333 WGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGLLKKDP 388 W GV+MY ++CG PFY ++ + + E F ++ +AK+L++ LL +P Sbjct: 239 WSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNP 298 Query: 389 KQR 391 +R Sbjct: 299 NER 301 >5YV8-A nrPDB Length = 298 Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 80/278 (28%), Positives = 136/278 (48%), Gaps = 32/278 (11%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIV----------------- 187 V +N++ +GKG++G V L + YYAMK+L K+ ++ Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 188 ------AKDEVAHTLTENRVLQNSRHPFLTALKYSFQ--THDRLCFVMEYANGGELFFHL 239 + + E +L+ HP + L D L V E N G + + Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM-EV 128 Query: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299 + SED+ARFY +++ ++YLH +K +++RD+K NL++ +DGHIKI DFG+ E Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQK-IIHRDIKPSNLLVGEDGHIKIADFGVSNEF 187 Query: 300 IKDGATMKTFCGTPEYLAPEVLEDND---YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEK 356 A + GTP ++APE L + G+A+D W +GV +Y + G+ PF ++ Sbjct: 188 KGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 247 Query: 357 LFELILMEEIRFPRT--LGPEAKSLLSGLLKKDPKQRL 392 L I + + FP + + K L++ +L K+P+ R+ Sbjct: 248 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI 285 >3FXW-A nrPDB Length = 336 Score = 125 bits (313), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 91/271 (33%), Positives = 142/271 (52%), Gaps = 28/271 (10%) Query: 140 KPKHRVTMNEFEYLK-LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 +PK ++++ K +LG G GKV+ + TG+ A+K+L + A+ EV H Sbjct: 20 EPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-YDSPKARQEVDHH--- 75 Query: 199 NRVLQNSRHPFLTAL--KYSFQTHDRLCF--VMEYANGGELFFHLSR--ERVFSEDRARF 252 Q S P + + Y H + C +ME GGELF + ++ F+E A Sbjct: 76 ---WQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAE 132 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTF 309 +I +A+ +LHS N+ +RD+K ENL+ +KD +K+TDFG KE ++ ++T Sbjct: 133 IMRDIGTAIQFLHSH-NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNA--LQTP 189 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF----ELILMEE 365 C TP Y+APEVL Y ++ D W LGV+MY ++CG PFY+ + + I + + Sbjct: 190 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQ 249 Query: 366 IRFPRT----LGPEAKSLLSGLLKKDPKQRL 392 FP + +AK L+ LLK DP +RL Sbjct: 250 YGFPNPEWSEVSEDAKQLIRLLLKTDPTERL 280 >4FIE-A nrPDB Length = 423 Score = 124 bits (312), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 136/257 (52%), Gaps = 13/257 (5%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G+G+ G V + +++G+ A +KK + + E ++++ +H + + Sbjct: 159 IGEGSTGIVCIATVRSSGKLVA---VKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 215 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 S+ D L VME+ GG L ++ R+ E A A ++ AL LH++ V++RD+ Sbjct: 216 SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLA-VLQALSVLHAQ-GVIHRDI 273 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 K ++++L DG +K++DFG C + K+ K+ GTP ++APE++ YG VD W L Sbjct: 274 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSL 333 Query: 336 GVVMYEMMCGRLPFYNQDHEKLFELI---LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 G+++ EM+ G P++N+ K ++I L ++ + P K L LL +DP QR Sbjct: 334 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR- 392 Query: 393 GGGSEDAKEIMQHRFFA 409 A E+++H F A Sbjct: 393 ----ATAAELLKHPFLA 405 >2YAB-A nrPDB Length = 361 Score = 124 bits (311), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 81/251 (32%), Positives = 130/251 (51%), Gaps = 19/251 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVI------VAKDEVAHTLTENRVLQNSRHPF 209 LG G F V +EK+TG YA K +KK V ++E+ ++ +L+ HP Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVS---ILRQVLHPN 76 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L ++ + ++E +GGELF L+++ SE+ A + +I+ ++YLH++K Sbjct: 77 IITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKK- 135 Query: 270 VVYRDLKLENLML-DKD---GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + + DLK EN+ML DK+ HIK+ DFGL E I+DG K GTPE++APE++ Sbjct: 136 IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPEFVAPEIVNYEP 194 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE----AKSLLS 381 G D W +GV+ Y ++ G PF ++ I F + AK + Sbjct: 195 LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIR 254 Query: 382 GLLKKDPKQRL 392 LL K+ ++RL Sbjct: 255 KLLVKETRKRL 265 >1PHK-A nrPDB Length = 298 Score = 124 bits (311), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 93/287 (32%), Positives = 146/287 (50%), Gaps = 30/287 (10%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV--IVAKDEVAH----TLTENRVLQ 203 +E ++LG+G V K T + YA+KI+ + +EV TL E +L+ Sbjct: 19 YEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILR 78 Query: 204 N-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 S HP + LK +++T+ V + GELF +L+ + SE R ++ + Sbjct: 79 KVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVIC 138 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 LH + N+V+RDLK EN++LD D +IK+TDFG + + G ++ CGTP YLAPE++E Sbjct: 139 ALH-KLNIVHRDLKPENILLDDDMNIKLTDFGFSCQ-LDPGEKLREVCGTPSYLAPEIIE 196 Query: 323 ----DND--YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE- 375 DN YG+ VD W GV+MY ++ G PF+++ + +I+ +F PE Sbjct: 197 CSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG---SPEW 253 Query: 376 ------AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHV 416 K L+S L P++R A+E + H FF V + V Sbjct: 254 DDYSDTVKDLVSRFLVVQPQKRY-----TAEEALAHPFFQQYVVEEV 295 >2J90-A nrPDB Length = 304 Score = 124 bits (310), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 84/252 (33%), Positives = 131/252 (51%), Gaps = 21/252 (8%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVI------VAKDEVAHTLTENRVLQNSRHPF 209 LG G F V ++K TG+ YA K +KK + V+++E+ E +L+ RHP Sbjct: 34 LGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIER---EVNILREIRHPN 90 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L F+ + ++E +GGELF L+ + +ED A + +I+ + YLHS K Sbjct: 91 IITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS-KR 149 Query: 270 VVYRDLKLENLML-DKD---GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + + DLK EN+ML DK+ IK+ DFG+ + I+ G K GTPE++APE++ Sbjct: 150 IAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHK-IEAGNEFKNIFGTPEFVAPEIVNYEP 208 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-----MEEIRFPRTLGPEAKSLL 380 G D W +GV+ Y ++ G PF + ++ I +E F T AK + Sbjct: 209 LGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNT-SELAKDFI 267 Query: 381 SGLLKKDPKQRL 392 LL KDPK+R+ Sbjct: 268 RRLLVKDPKRRM 279 >2Q0N-A nrPDB Length = 301 Score = 124 bits (310), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 136/257 (52%), Gaps = 13/257 (5%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G+G+ G V + +++G+ A +KK + + E ++++ +H + + Sbjct: 37 IGEGSTGIVCIATVRSSGKLVA---VKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 93 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 S+ D L VME+ GG L ++ R+ E A A ++ AL LH++ V++RD+ Sbjct: 94 SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLA-VLQALSVLHAQ-GVIHRDI 151 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 K ++++L DG +K++DFG C + K+ K+ GTP ++APE++ YG VD W L Sbjct: 152 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSL 211 Query: 336 GVVMYEMMCGRLPFYNQDHEKLFELI---LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 G+++ EM+ G P++N+ K ++I L ++ + P K L LL +DP QR Sbjct: 212 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR- 270 Query: 393 GGGSEDAKEIMQHRFFA 409 A E+++H F A Sbjct: 271 ----ATAAELLKHPFLA 283 >3NCG-A nrPDB Length = 486 Score = 124 bits (310), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 82/245 (33%), Positives = 127/245 (51%), Gaps = 11/245 (4%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LGKG+FG+V+ K++ T + YA+K++ K KD + L E +L+ HP + L Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKD-TSTILREVELLKKLDHPNIMKLF 87 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 + V E GGELF + + + FSE A ++ S + Y+H + N+V+RD Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH-KHNIVHRD 146 Query: 275 LKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVD 331 LK EN++L +KD IKI DFGL + MK GT Y+APEVL Y D Sbjct: 147 LKPENILLESKEKDCDIKIIDFGLST-CFQQNTKMKDRIGTAYYIAPEVLRGT-YDEKCD 204 Query: 332 WWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLKKD 387 W GV++Y ++ G PFY ++ + + + + F RT+ +AK L+ +L Sbjct: 205 VWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTFH 264 Query: 388 PKQRL 392 P R+ Sbjct: 265 PSLRI 269 >4JDH-A nrPDB Length = 346 Score = 124 bits (310), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 136/257 (52%), Gaps = 13/257 (5%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G+G+ G V + +++G+ A +KK + + E ++++ +H + + Sbjct: 82 IGEGSTGIVCIATVRSSGKLVA---VKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 138 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 S+ D L VME+ GG L ++ R+ E A A ++ AL LH++ V++RD+ Sbjct: 139 SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLA-VLQALSVLHAQ-GVIHRDI 196 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 K ++++L DG +K++DFG C + K+ K+ GTP ++APE++ YG VD W L Sbjct: 197 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSL 256 Query: 336 GVVMYEMMCGRLPFYNQDHEKLFELI---LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 G+++ EM+ G P++N+ K ++I L ++ + P K L LL +DP QR Sbjct: 257 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR- 315 Query: 393 GGGSEDAKEIMQHRFFA 409 A E+++H F A Sbjct: 316 ----ATAAELLKHPFLA 328 >4XBR-A nrPDB Length = 366 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 136/257 (52%), Gaps = 13/257 (5%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G+G+ G V + +++G+ A +KK + + E ++++ +H + + Sbjct: 102 IGEGSTGIVCIATVRSSGKLVA---VKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 158 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 S+ D L VME+ GG L ++ R+ E A A ++ AL LH++ V++RD+ Sbjct: 159 SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLA-VLQALSVLHAQ-GVIHRDI 216 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 K ++++L DG +K++DFG C + K+ K+ GTP ++APE++ YG VD W L Sbjct: 217 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSL 276 Query: 336 GVVMYEMMCGRLPFYNQDHEKLFELI---LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 G+++ EM+ G P++N+ K ++I L ++ + P K L LL +DP QR Sbjct: 277 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR- 335 Query: 393 GGGSEDAKEIMQHRFFA 409 A E+++H F A Sbjct: 336 ----ATAAELLKHPFLA 348 >3DFA-A nrPDB Length = 286 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 82/250 (32%), Positives = 129/250 (51%), Gaps = 11/250 (4%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 + + +LGKG+FG+V+ K++ T + YA+K++ K KD + L E +L+ HP Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKD-TSTILREVELLKKLDHPN 82 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L + V E GGELF + + + FSE A ++ S + Y+H + N Sbjct: 83 IMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH-KHN 141 Query: 270 VVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +V+RDLK EN++L +KD IKI DFGL + MK GT Y+APEVL Y Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGL-STCFQQNTKMKDRIGTAYYIAPEVLRGT-Y 199 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSG 382 D W GV++Y ++ G PFY ++ + + + + F RT+ +AK L+ Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 383 LLKKDPKQRL 392 +L P R+ Sbjct: 260 MLTFHPSLRI 269 >5JN2-A nrPDB Length = 525 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 89/275 (32%), Positives = 138/275 (50%), Gaps = 23/275 (8%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 ++LGKG+FG+VIL K+K TG+ A+K++ K + K + L E ++L+ HP + L Sbjct: 73 RVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKL 132 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSE-DRARFYGAEIVSALDYLHSEKNVVY 272 F+ V E GGELF + + FSE D AR +++S + Y+H K +V+ Sbjct: 133 YEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARII-RQVLSGITYMHKNK-IVH 190 Query: 273 RDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 RDLK ENL+L+ KD +I+I DFGL + MK GT Y+APEVL Y Sbjct: 191 RDLKPENLLLESKSKDANIRIIDFGLSTH-FEASKKMKDKIGTAYYIAPEVLHGT-YDEK 248 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLK 385 D W GV++Y ++ G PF + + + + + F + + AK L+ +L Sbjct: 249 CDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLT 308 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420 P R+ A++ + H W Y K+ Sbjct: 309 YVPSMRIS-----ARDALDHE------WIQTYTKE 332 >2YCR-A nrPDB Length = 323 Score = 122 bits (306), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 99/308 (32%), Positives = 150/308 (48%), Gaps = 28/308 (9%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA-----KDEVAHTLTENRVL 202 +E+ K LG G G+V L E+ T + A+KI+ K D + TE +L Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + HP + +K F D V+E GGELF + + E + Y +++ A+ Sbjct: 70 KKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 263 YLHSEKNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 YLH E +++RDLK EN++L ++D IKITDFG K + + + M+T CGTP YLAPE Sbjct: 129 YLH-ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTYLAPE 186 Query: 320 VLED---NDYGRAVDWWGLGVVMYEMMCGRLPFY-NQDHEKLFELILMEEIRF-PRT--- 371 VL Y RAVD W LGV+++ + G PF ++ L + I + F P Sbjct: 187 VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAE 246 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLS----PPFKP 427 + +A L+ LL DPK R +E ++H + + ++ LS KP Sbjct: 247 VSEKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDEDMKRKFQDLLSEENESTAKP 301 Query: 428 QVTSETDT 435 QV ++ T Sbjct: 302 QVLAQPST 309 >3MA6-A nrPDB Length = 298 Score = 122 bits (305), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 135/273 (49%), Gaps = 21/273 (7%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 ++LGKG+FG+VIL K+K TG+ A+K++ K + K + L E ++L+ HP + L Sbjct: 38 RVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKL 97 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYR 273 F+ V E GGELF + + FSE A +++S + Y+H K +V+R Sbjct: 98 YEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNK-IVHR 156 Query: 274 DLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330 DLK ENL+L+ KD +I+I DFGL + MK GT Y+APEVL Y Sbjct: 157 DLKPENLLLESKSKDANIRIIDFGLSTH-FEASKKMKDKIGTAYYIAPEVLHGT-YDEKC 214 Query: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLKK 386 D W GV++Y ++ G PF + + + + + F + + AK L+ +L Sbjct: 215 DVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTY 274 Query: 387 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEK 419 P R+ A++ + H W Y K Sbjct: 275 VPSMRIS-----ARDALDHE------WIQTYTK 296 >4YZB-A nrPDB Length = 491 Score = 121 bits (303), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 85/262 (32%), Positives = 134/262 (51%), Gaps = 15/262 (5%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 ++LGKG+FG+VIL K+K TG+ YA+K++ K + K + L E +L+ HP + L Sbjct: 36 RVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKL 95 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYR 273 F+ V E GGELF + + FSE A +++S + Y+H K +V+R Sbjct: 96 YEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNK-IVHR 154 Query: 274 DLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330 DLK ENL+L+ KD +I+I DFGL + MK GT Y+APEVL Y Sbjct: 155 DLKPENLLLENKRKDANIRIIDFGLSTH-FESTKKMKDKIGTAYYIAPEVLHGT-YDEKC 212 Query: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLKK 386 D W GV++Y ++ G PF + + + + + F + + AK L+ +L Sbjct: 213 DVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAY 272 Query: 387 DPKQRLGGGSEDAKEIMQHRFF 408 P R+ A++ ++H + Sbjct: 273 VPTMRIS-----ARDALEHEWL 289 >4NIF-A nrPDB Length = 333 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 82/261 (31%), Positives = 132/261 (50%), Gaps = 23/261 (8%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G G++ + KAT YA+K++ K +E+ +L+ +HP + LK Sbjct: 16 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------EILLRYGQHPNIITLKD 69 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 + + V E GGEL + R++ FSE A F I ++YLHS+ VV+RDL Sbjct: 70 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDL 128 Query: 276 KLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVD 331 K N++ +D+ G+ ++I DFG K+ + + T C T ++APEVL+ Y D Sbjct: 129 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 188 Query: 332 WWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------RTLGPEAKSLLSGLL 384 W LG+++Y M+ G PF N + E++ + +F T+ AK L+S +L Sbjct: 189 IWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKML 248 Query: 385 KKDPKQRLGGGSEDAKEIMQH 405 DP QRL AK+++QH Sbjct: 249 HVDPHQRL-----TAKQVLQH 264 >2A27-A nrPDB Length = 321 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 80/251 (31%), Positives = 130/251 (51%), Gaps = 19/251 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVI------VAKDEVAHTLTENRVLQNSRHPF 209 LG G F V +EK+TG YA K +KK V+++E+ ++ +L+ H Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVS---ILRQVLHHN 76 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L ++ + ++E +GGELF L+++ SE+ A + +I+ ++YLH++K Sbjct: 77 VITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKK- 135 Query: 270 VVYRDLKLENLML-DKD---GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + + DLK EN+ML DK+ HIK+ DFGL E I+DG K GTPE++APE++ Sbjct: 136 IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPEFVAPEIVNYEP 194 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE----AKSLLS 381 G D W +GV+ Y ++ G PF ++ I F + AK + Sbjct: 195 LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIR 254 Query: 382 GLLKKDPKQRL 392 LL K+ ++RL Sbjct: 255 KLLVKETRKRL 265 >3I6U-A nrPDB Length = 419 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 89/261 (34%), Positives = 131/261 (50%), Gaps = 19/261 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA-----KDEVAHTLTENRVL 202 +E+ K LG G G+V L E+ T + A++I+ K D + TE +L Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + HP + +K F D V+E GGELF + + E + Y +++ A+ Sbjct: 195 KKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 263 YLHSEKNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 YLH E +++RDLK EN++L ++D IKITDFG K + + + M+T CGTP YLAPE Sbjct: 254 YLH-ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTYLAPE 311 Query: 320 VLED---NDYGRAVDWWGLGVVMYEMMCGRLPFY-NQDHEKLFELILMEEIRFPRTLGPE 375 VL Y RAVD W LGV+++ + G PF ++ L + I + F + E Sbjct: 312 VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAE 371 Query: 376 ----AKSLLSGLLKKDPKQRL 392 A L+ LL DPK R Sbjct: 372 VSEKALDLVKKLLVVDPKARF 392 >1ZWS-A nrPDB Length = 288 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 82/252 (32%), Positives = 132/252 (52%), Gaps = 21/252 (8%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVI------VAKDEVAHTLTENRVLQNSRHPF 209 LG G F V +EK+TG YA K +KK V+++E+ ++ +L+ H Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVS---ILRQVLHHN 76 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L ++ + ++E +GGELF L+++ SE+ A + +I+ ++YLH++K Sbjct: 77 VITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKK- 135 Query: 270 VVYRDLKLENLML-DKD---GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + + DLK EN+ML DK+ HIK+ DFGL E I+DG K GTPE++APE++ Sbjct: 136 IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPEFVAPEIVNYEP 194 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-----MEEIRFPRTLGPEAKSLL 380 G D W +GV+ Y ++ G PF ++ I +E F T AK + Sbjct: 195 LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHT-SELAKDFI 253 Query: 381 SGLLKKDPKQRL 392 LL K+ ++RL Sbjct: 254 RKLLVKETRKRL 265 >6FDY-U nrPDB Length = 276 Score = 118 bits (296), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 78/253 (30%), Positives = 131/253 (51%), Gaps = 9/253 (3%) Query: 147 MNEFEYLKLLGKGTFGKVI-LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 ++ F + LG GT+ V +K T A+K + K+ + K V + LTE +L+ Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSL-NKASVENLLTEIEILKGI 68 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 RHP + LK D + +ME+ GG+L + R+ E AR + ++ SAL +LH Sbjct: 69 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 128 Query: 266 SEKNVVYRDLKLENLMLD--KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 E+N+ + DLK +N++L + H+K+ DFG + + G+P Y+APE++ Sbjct: 129 -ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQH-MSPWDEKHVLRGSPLYMAPEMVCQ 186 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---EIRFPRTLGPEAKSLL 380 Y VD W +GV++YE + G+ PF ++ +L E I E+ L + + LL Sbjct: 187 RQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 246 Query: 381 SGLLKKDPKQRLG 393 LL++DP +R+ Sbjct: 247 QRLLERDPSRRIS 259 >2F57-A nrPDB Length = 317 Score = 117 bits (294), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 80/263 (30%), Positives = 135/263 (51%), Gaps = 27/263 (10%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G+G+ G V + EK TG+ A +KK + + E ++++ H + + Sbjct: 53 IGEGSTGIVCIATEKHTGKQVA---VKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYS 109 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 S+ D L VME+ GG L ++ R+ +E++ ++ AL YLH++ V++RD+ Sbjct: 110 SYLVGDELWVVMEFLEGGALTDIVTHTRM-NEEQIATVCLSVLRALSYLHNQ-GVIHRDI 167 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 K ++++L DG IK++DFG C + K+ K+ GTP ++APEV+ YG VD W L Sbjct: 168 KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSL 227 Query: 336 GVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL----------LSGLLK 385 G+++ EM+ G P++N+ L M IR +L P K L L +L Sbjct: 228 GIMVIEMIDGEPPYFNEP-----PLQAMRRIR--DSLPPRVKDLHKVSSVLRGFLDLMLV 280 Query: 386 KDPKQRLGGGSEDAKEIMQHRFF 408 ++P QR A+E++ H F Sbjct: 281 REPSQR-----ATAQELLGHPFL 298 >4KS7-A nrPDB Length = 292 Score = 117 bits (294), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 76/261 (29%), Positives = 143/261 (54%), Gaps = 16/261 (6%) Query: 152 YLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL-TENRVLQNSRHPFL 210 Y+K+ G+G+ G V L +EK +GR A+K++ + K + L E ++++ +H + Sbjct: 28 YVKI-GEGSTGIVCLAREKHSGRQVAVKMMD----LRKQQRRELLFNEVVIMRDYQHFNV 82 Query: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNV 270 + S+ + L +ME+ GG L +S+ R+ E A A ++ AL YLH++ V Sbjct: 83 VEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEA-VLQALAYLHAQ-GV 140 Query: 271 VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330 ++RD+K ++++L DG +K++DFG C + KD K+ GTP ++APEV+ + Y V Sbjct: 141 IHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEV 200 Query: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---EIRFPRTLGPEAKSLLSGLLKKD 387 D W LG+++ EM+ G P+++ + + + +++ + P + L +L +D Sbjct: 201 DIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRD 260 Query: 388 PKQRLGGGSEDAKEIMQHRFF 408 P++R A+E++ H F Sbjct: 261 PQER-----ATAQELLDHPFL 276 >3LIJ-A nrPDB Length = 494 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 84/263 (31%), Positives = 137/263 (52%), Gaps = 16/263 (6%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 ++ +K LG G +G+V+L ++K T A+KI++K V+ + L E VL+ HP Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRK-TSVSTSSNSKLLEEVAVLKLLDHPN 97 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L F+ VME GGELF + F+E A +++S + YLH + N Sbjct: 98 IMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH-KHN 156 Query: 270 VVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +V+RDLK ENL+L +KD IKI DFGL ++ MK GT Y+APEVL Y Sbjct: 157 IVHRDLKPENLLLESKEKDALIKIVDFGLSAV-FENQKKMKERLGTAYYIAPEVLR-KKY 214 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSG 382 D W +GV+++ ++ G PF Q +++ + + F + + AK L+ Sbjct: 215 DEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQ 274 Query: 383 LLKKDPKQRLGGGSEDAKEIMQH 405 +L+ D ++R+ A++ ++H Sbjct: 275 MLQFDSQRRIS-----AQQALEH 292 >4RGJ-A nrPDB Length = 520 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 87/275 (31%), Positives = 144/275 (52%), Gaps = 19/275 (6%) Query: 144 RVTMNE-FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 V NE ++ +K+LGKG+FG+VIL ++K TG YA+K++ K+ + K + L E +L Sbjct: 55 NVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELL 114 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH-LSRERVFSEDRARFYGAEIVSAL 261 + H + L F+ ++ V + GGELF +SR+R + D AR +I+S + Sbjct: 115 KMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARII-KQILSGI 173 Query: 262 DYLHSEKNVVYRDLKLENLMLD----KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 Y+H + NVV+RDLK EN++L+ +D IKI DFGL + MK GT Y+A Sbjct: 174 TYMH-KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTH-FEYSKKMKDKIGTAYYIA 231 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLG 373 P+VL Y D W GV++Y ++ G PF + + + + + F + + Sbjct: 232 PDVLHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKIS 290 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +AK L+ +L R+ A++ ++H + Sbjct: 291 DKAKDLIKKMLMYTSAVRIS-----ARDALEHEWI 320 >2HW6-A nrPDB Length = 307 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 90/292 (30%), Positives = 142/292 (48%), Gaps = 44/292 (15%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 +LLG+G + KV G+ YA+KI++K+ ++ V + Q +++ L + Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKN-ILELI 77 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYR 273 ++ F+ R V E GG + H+ +++ F+E A ++ +ALD+LH+ K + +R Sbjct: 78 EF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHT-KGIAHR 135 Query: 274 DLKLENLML---DKDGHIKITDFGLCKEGIKDGAT--------MKTFCGTPEYLAPEVLE 322 DLK EN++ +K +KI DF L G+K + + T CG+ EY+APEV+E Sbjct: 136 DLKPENILCESPEKVSPVKICDFDL-GSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 194 Query: 323 -----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---------------DHEKLFELIL 362 Y + D W LGVV+Y M+ G PF KLFE I Sbjct: 195 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 254 Query: 363 MEEIRFPRT----LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 + FP + EAK L+S LL +D KQRL A +++QH + G Sbjct: 255 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQG 301 >3TAC-A nrPDB Length = 361 Score = 115 bits (288), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 79/260 (30%), Positives = 135/260 (51%), Gaps = 23/260 (8%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT------ENRVLQ 203 +E +++GKG F V + TG+ +A+KI V VAK + L+ E + Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKI----VDVAKFTSSPGLSTEDLKREASICH 83 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER----VFSEDRARFYGAEIVS 259 +HP + L ++ + L V E+ +G +L F + + V+SE A Y +I+ Sbjct: 84 MLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILE 143 Query: 260 ALDYLHSEKNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 316 AL Y H + N+++RD+K ++L + +K+ FG+ + + G GTP ++ Sbjct: 144 ALRYCH-DNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFM 202 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRF-PRT---L 372 APEV++ YG+ VD WG GV+++ ++ G LPFY E+LFE I+ + + PR + Sbjct: 203 APEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTK-ERLFEGIIKGKYKMNPRQWSHI 261 Query: 373 GPEAKSLLSGLLKKDPKQRL 392 AK L+ +L DP +R+ Sbjct: 262 SESAKDLVRRMLMLDPAERI 281 >4FZF-B nrPDB Length = 283 Score = 114 bits (286), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 84/263 (31%), Positives = 129/263 (49%), Gaps = 14/263 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F L+ +GKG+FG+V + T + A+KI+ ++ A+DE+ E VL + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKII--DLEEAEDEIEDIQQEITVLSQCDSSY 67 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 +T S+ +L +MEY GG L R F E + EI+ LDYLHSEK Sbjct: 68 VTKYYGSYLKGSKLWIIMEYLGGGSAL-DLLRAGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 + +RD+K N++L + G +K+ FG+ + TF GTP ++APEV++ + Y Sbjct: 127 I-HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK 185 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS---LLSGLLKK 386 D W LG+ E+ G P N D + L L+ + P +G KS + L K Sbjct: 186 ADIWSLGITAIELAKGEPP--NSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNK 243 Query: 387 DPKQRLGGGSEDAKEIMQHRFFA 409 DP R AKE+++H+F Sbjct: 244 DPSFR-----PTAKELLKHKFIV 261 >3IS5-A nrPDB Length = 285 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 87/269 (32%), Positives = 136/269 (50%), Gaps = 20/269 (7%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F + + LG G FG V LV+E+++G +K + K+ ++ + E VL++ HP Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD--RSQVPMEQIEAEIEVLKSLDHPN 81 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHL----SRERVFSEDRARFYGAEIVSALDYLH 265 + + F+ + + VME GGEL + +R + SE ++++AL Y H Sbjct: 82 IIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFH 141 Query: 266 SEKNVVYRDLKLENLML-DKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 S+ +VV++DLK EN++ D H IKI DFGL E K GT Y+APEV + Sbjct: 142 SQ-HVVHKDLKPENILFQDTSPHSPIKIIDFGLA-ELFKSDEHSTNAAGTALYMAPEVFK 199 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSL 379 D D W GVVMY ++ G LPF E++ + +E + R L P+A L Sbjct: 200 -RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAVDL 258 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L +L KDP++R A +++ H +F Sbjct: 259 LKQMLTKDPERR-----PSAAQVLHHEWF 282 >1KOB-A nrPDB Length = 387 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 74/250 (29%), Positives = 127/250 (50%), Gaps = 12/250 (4%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 ++ L+ LG G FG V EKATGR + K + + K V + ++ ++ HP Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEIS---IMNQLHHPK 109 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLHSEK 268 L L +F+ + ++E+ +GGELF ++ E SE Y + L ++H E Sbjct: 110 LINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMH-EH 168 Query: 269 NVVYRDLKLENLMLD--KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 ++V+ D+K EN+M + K +KI DFGL + + +K T E+ APE+++ Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATK-LNPDEIVKVTTATAEFAAPEIVDREPV 227 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSG 382 G D W +GV+ Y ++ G PF +D + + + + F ++ PEAK + Sbjct: 228 GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKN 287 Query: 383 LLKKDPKQRL 392 LL+K+P++RL Sbjct: 288 LLQKEPRKRL 297 >1NY3-A nrPDB Length = 400 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 83/252 (32%), Positives = 126/252 (50%), Gaps = 18/252 (7%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 ++LG G GKV+ + K T +A+K+L+ + A+ EV ++ R + Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVELHWRASQCPHIVR--IVDVY 124 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 + + L VME +GGELF + ++ F+E A I A+ YLHS N+ Sbjct: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-INIA 183 Query: 272 YRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 +RD+K ENL+ + +K+TDFG KE + + T C TP Y+APEVL Y + Sbjct: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGPEKYDK 242 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIRFPRT----LGPEAKSLL 380 + D W LGV+MY ++CG PFY+ + I M + FP + E K L+ Sbjct: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 Query: 381 SGLLKKDPKQRL 392 LLK +P QR+ Sbjct: 303 RNLLKTEPTQRM 314 >2OZA-A nrPDB Length = 356 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 83/252 (32%), Positives = 126/252 (50%), Gaps = 18/252 (7%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 ++LG G GKV+ + K T +A+K+L+ + A+ EV ++ R + Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVELHWRASQCPHIVR--IVDVY 80 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 + + L VME +GGELF + ++ F+E A I A+ YLHS N+ Sbjct: 81 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-INIA 139 Query: 272 YRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 +RD+K ENL+ + +K+TDFG KE + + T C TP Y+APEVL Y + Sbjct: 140 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGPEKYDK 198 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIRFPRT----LGPEAKSLL 380 + D W LGV+MY ++CG PFY+ + I M + FP + E K L+ Sbjct: 199 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 258 Query: 381 SGLLKKDPKQRL 392 LLK +P QR+ Sbjct: 259 RNLLKTEPTQRM 270 >4JG6-A nrPDB Length = 355 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 83/270 (30%), Positives = 135/270 (50%), Gaps = 21/270 (7%) Query: 137 SLAKPKHRVTM---NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA 193 S+ + HR ++ + +E + +G G++ KAT +A+KI+ K +E+ Sbjct: 21 SIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI- 79 Query: 194 HTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253 +L+ +HP + LK + + V E GGEL + R++ FSE A Sbjct: 80 -----EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAV 134 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTF 309 I ++YLH++ VV+RDLK N++ +D+ G+ I+I DFG K+ + + T Sbjct: 135 LFTITKTVEYLHAQ-GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP 193 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRF 368 C T ++APEVLE Y A D W LGV++Y M+ G PF N + E++ + +F Sbjct: 194 CYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKF 253 Query: 369 P------RTLGPEAKSLLSGLLKKDPKQRL 392 ++ AK L+S +L DP QRL Sbjct: 254 SLSGGYWNSVSDTAKDLVSKMLHVDPHQRL 283 >1KOA-A nrPDB Length = 491 Score = 112 bits (280), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 79/259 (30%), Positives = 126/259 (48%), Gaps = 14/259 (5%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 KH ++ ++ + LG G FG V V E+ATG +A K + K+ V + V Sbjct: 45 KHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSV 104 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEIVSA 260 L RHP L L +F+ + + + E+ +GGELF ++ E SED A Y ++ Sbjct: 105 L---RHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKG 161 Query: 261 LDYLHSEKNVVYRDLKLENLML--DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 L ++H E N V+ DLK EN+M + +K+ DFGL + ++K GT E+ AP Sbjct: 162 LCHMH-ENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAH-LDPKQSVKVTTGTAEFAAP 219 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-----MEEIRFPRTLG 373 EV E G D W +GV+ Y ++ G PF ++ ++ + M++ F + Sbjct: 220 EVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAF-SGIS 278 Query: 374 PEAKSLLSGLLKKDPKQRL 392 + K + LL DP R+ Sbjct: 279 EDGKDFIRKLLLADPNTRM 297 >6HXF-B nrPDB Length = 302 Score = 112 bits (279), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 73/271 (26%), Positives = 136/271 (50%), Gaps = 18/271 (6%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 +E + LG G FGKV K K TG A K+++ + +++E+ + E +L HP+ Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETK---SEEELEDYIVEIEILATCDHPY 77 Query: 210 LTALKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 + L ++ +L ++E+ GG + L +R +E + + +++ AL++LHS K Sbjct: 78 IVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS-K 136 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV-----LED 323 +++RDLK N+++ +G I++ DFG+ + +K +F GTP ++APEV ++D Sbjct: 137 RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKD 196 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPRTLGPEAKSLL 380 Y D W LG+ + EM P + + ++ I + + P E + L Sbjct: 197 TPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFL 256 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 L K+P+ R A ++++H F + I Sbjct: 257 KIALDKNPETR-----PSAAQLLEHPFVSSI 282 >3UTO-A nrPDB Length = 573 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 79/259 (30%), Positives = 126/259 (48%), Gaps = 14/259 (5%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 KH ++ ++ + LG G FG V V E+ATG +A K + K+ V + V Sbjct: 151 KHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSV 210 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEIVSA 260 L RHP L L +F+ + + + E+ +GGELF ++ E SED A Y ++ Sbjct: 211 L---RHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKG 267 Query: 261 LDYLHSEKNVVYRDLKLENLML--DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 L ++H E N V+ DLK EN+M + +K+ DFGL + ++K GT E+ AP Sbjct: 268 LCHMH-ENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAH-LDPKQSVKVTTGTAEFAAP 325 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-----MEEIRFPRTLG 373 EV E G D W +GV+ Y ++ G PF ++ ++ + M++ F + Sbjct: 326 EVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAF-SGIS 384 Query: 374 PEAKSLLSGLLKKDPKQRL 392 + K + LL DP R+ Sbjct: 385 EDGKDFIRKLLLADPNTRM 403 >3GUB-A nrPDB Length = 295 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 77/251 (30%), Positives = 125/251 (49%), Gaps = 19/251 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVI------VAKDEVAHTLTENRVLQNSRHPF 209 LG G F V +EK+TG YA K +KK V+++++ ++ +L+ +HP Sbjct: 19 LGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVS---ILKEIQHPN 75 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L ++ + + E GGELF L+ + +E+ A + +I++ + YLHS + Sbjct: 76 VITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQ- 134 Query: 270 VVYRDLKLENLML-DKD---GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + + DLK EN+ML D++ IKI DFGL + I G K GTPE++APE++ Sbjct: 135 IAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK-IDFGNEFKNIFGTPEFVAPEIVNYEP 193 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLS 381 G D W +GV+ Y ++ G PF ++ + F AK + Sbjct: 194 LGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIR 253 Query: 382 GLLKKDPKQRL 392 LL KDPK+R+ Sbjct: 254 RLLVKDPKKRM 264 >5J5T-A nrPDB Length = 370 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 87/306 (28%), Positives = 148/306 (48%), Gaps = 30/306 (9%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + +FE ++ +G GT+G V + TG A+K++K E ++ A E ++++ Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE---PGEDFAVVQQEIIMMKDC 58 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDY 263 +HP + A S+ D+L ME+ GG L +H++ SE + + E + L Y Sbjct: 59 KHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP--LSELQIAYVSRETLQGLYY 116 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-- 321 LHS K ++RD+K N++L +GH+K+ DFG+ + A K F GTP ++APEV Sbjct: 117 LHS-KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAV 175 Query: 322 -EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRF-PRTLGPEAK-- 377 Y + D W +G+ E+ + P + D + L LM + F P L + K Sbjct: 176 ERKGGYNQLCDLWAVGITAIELAELQPPMF--DLHPMRALFLMTKSNFQPPKLKDKMKWS 233 Query: 378 ----SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSET 433 + L K+PK+R A++++QH F V QH+ + L+ +V + Sbjct: 234 NSFHHFVKMALTKNPKKR-----PTAEKLLQHPF----VTQHL-TRSLAIELLDKVNNPD 283 Query: 434 DTRYFD 439 + Y D Sbjct: 284 HSTYHD 289 >6CCF-A nrPDB Length = 290 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 82/279 (29%), Positives = 138/279 (49%), Gaps = 32/279 (11%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVI----------------VA 188 + +N+++ +GKG +G V L ++ R+YAMK+L K+ + A Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 189 KDEVAHTL-------TENRVLQNSRHPFLTALKYSFQ--THDRLCFVMEYANGGELFFHL 239 + A L E +L+ H + L D L V + G + + Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVM-EV 120 Query: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299 ++ FSE++AR Y +++ L+YLH +K +V+RD+K NL+L DGH+KI DFG+ + Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQK-IVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 300 IKDGATMKTFCGTPEYLAPEVLEDND---YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEK 356 + A + + GTP ++APE + D+ G+A+D W GV +Y + G+ PF + Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 239 Query: 357 LFELILMEEIRFPR--TLGPEAKSLLSGLLKKDPKQRLG 393 L I E + FP + E K L+ +L K+P+ R+G Sbjct: 240 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIG 278 >3KA0-A nrPDB Length = 320 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 82/252 (32%), Positives = 125/252 (49%), Gaps = 18/252 (7%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 ++LG G GKV+ + K T +A+K+L+ + A+ EV ++ R + Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVELHWRASQCPHIVR--IVDVY 78 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 + + L VME +GGELF + ++ F+E A I A+ YLHS N+ Sbjct: 79 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-INIA 137 Query: 272 YRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 +RD+K ENL+ + +K+TDFG KE + + C TP Y+APEVL Y + Sbjct: 138 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEP-CYTPYYVAPEVLGPEKYDK 196 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIRFPRT----LGPEAKSLL 380 + D W LGV+MY ++CG PFY+ + I M + FP + E K L+ Sbjct: 197 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 256 Query: 381 SGLLKKDPKQRL 392 LLK +P QR+ Sbjct: 257 RNLLKTEPTQRM 268 >3LM0-A nrPDB Length = 327 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 77/248 (31%), Positives = 127/248 (51%), Gaps = 13/248 (5%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH-PFLTA 212 K LG+G F V K+TG+ YA K LKK +D A L E VL+ ++ P + Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAEILHEIAVLELAKSCPRVIN 93 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSALDYLHSEKNV 270 L ++ + ++EYA GGE+F E + SE+ +I+ + YLH + N+ Sbjct: 94 LHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLH-QNNI 152 Query: 271 VYRDLKLENLMLDKD---GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 V+ DLK +N++L G IKI DFG+ ++ I ++ GTPEYLAPE+L + Sbjct: 153 VHLDLKPQNILLSSIYPLGDIKIVDFGMSRK-IGHACELREIMGTPEYLAPEILNYDPIT 211 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGL 383 A D W +G++ Y ++ PF +D+++ + I + + ++ A + L Sbjct: 212 TATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSL 271 Query: 384 LKKDPKQR 391 L K+P++R Sbjct: 272 LVKNPEKR 279 >4WNO-A nrPDB Length = 287 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 72/221 (32%), Positives = 113/221 (51%), Gaps = 26/221 (11%) Query: 146 TMNEFEYLK--LLGKGTFGKVILVKEKATGRYYAMKILKKEV-IVAKDEVAHTLT----E 198 T+ +FE+ + L+G G F V GR+ A L+ V + K +A + T E Sbjct: 14 TVGKFEFSRKDLIGHGAFAVVF------KGRHRAAHDLEVAVKCINKKNLAKSQTLLGKE 67 Query: 199 NRVLQNSRHPFLTALKYSFQ-THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257 ++L+ +H + AL Y FQ + + VMEY NGG+L +L R SED R + +I Sbjct: 68 IKILKELKHENIVAL-YDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQI 126 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDG---------HIKITDFGLCKEGIKDGATMKT 308 A+ LHS K +++RDLK +N++L +KI DFG + ++ T Sbjct: 127 AGAMRLLHS-KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARY-LQSNMMAAT 184 Query: 309 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 CG+P Y+APEV+ Y D W +G ++Y+ + G+ PF Sbjct: 185 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPF 225 >2XIK-A nrPDB Length = 294 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 82/263 (31%), Positives = 127/263 (48%), Gaps = 14/263 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F L +GKG+FG+V + T A+KI+ ++ A+DE+ E VL P+ Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKII--DLEEAEDEIEDIQQEITVLSQCDSPY 78 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 +T S+ +L +MEY GG L + E EI+ LDYLHSE+ Sbjct: 79 ITRYFGSYLKSTKLWIIMEYLGGGSAL-DLLKPGPLEETYIATILREILKGLDYLHSERK 137 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 + +RD+K N++L + G +K+ DFG+ + TF GTP ++APEV++ + Y Sbjct: 138 I-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK 196 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA---KSLLSGLLKK 386 D W LG+ E+ G P N D + L L+ + P G + K + L K Sbjct: 197 ADIWSLGITAIELAKGEPP--NSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNK 254 Query: 387 DPKQRLGGGSEDAKEIMQHRFFA 409 DP+ R AKE+++H+F Sbjct: 255 DPRFR-----PTAKELLKHKFIT 272 >2X4F-A nrPDB Length = 373 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 82/264 (31%), Positives = 137/264 (51%), Gaps = 19/264 (7%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 ++LG G FG+V +E ATG A KI+K + K+EV + ++ V+ H L L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEIS---VMNQLDHANLIQL 151 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLHSEKNVVY 272 +F++ + + VMEY +GGELF + E +E + +I + ++H + +++ Sbjct: 152 YDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMH-QMYILH 210 Query: 273 RDLKLENLM-LDKDG-HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330 DLK EN++ +++D IKI DFGL + K +K GTPE+LAPEV+ + Sbjct: 211 LDLKPENILCVNRDAKQIKIIDFGLARR-YKPREKLKVNFGTPEFLAPEVVNYDFVSFPT 269 Query: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-----MEEIRFPRTLGPEAKSLLSGLLK 385 D W +GV+ Y ++ G PF + + IL +E+ F + + EAK +S LL Sbjct: 270 DMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF-QDISEEAKEFISKLLI 328 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFA 409 K+ R+ A E ++H + + Sbjct: 329 KEKSWRIS-----ASEALKHPWLS 347 >4QMW-A nrPDB Length = 310 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 90/293 (30%), Positives = 140/293 (47%), Gaps = 20/293 (6%) Query: 119 DFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178 +F + SP SG M+ A P+ F L+ +GKG+FG+V + T + A+ Sbjct: 6 EFMAHSPV-QSGLPGMQNLKADPEEL-----FTKLEKIGKGSFGEVFKGIDNRTQKVVAI 59 Query: 179 KILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238 KI+ ++ A+DE+ E VL P++T S+ +L +MEY GG Sbjct: 60 KII--DLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSAL-D 116 Query: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298 L E + EI+ LDYLHSEK + +RD+K N++L + G +K+ DFG+ + Sbjct: 117 LLEPGPLDETQIATILREILKGLDYLHSEKKI-HRDIKAANVLLSEHGEVKLADFGVAGQ 175 Query: 299 GIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 358 TF GTP ++APEV++ + Y D W LG+ E+ G P K+ Sbjct: 176 LTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKV- 234 Query: 359 ELILMEEIRFPRTLGPEAKSL---LSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L L+ + P G +K L + L K+P R AKE+++H+F Sbjct: 235 -LFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFR-----PTAKELLKHKFI 281 >6CKI-A nrPDB Length = 316 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 89/293 (30%), Positives = 135/293 (46%), Gaps = 44/293 (15%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G +V T + YA+KI++K+ + V + + Q H + L Sbjct: 20 VLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREV--EMLYQCQGHRNVLELI 77 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 F+ DR V E GG + H+ + R F+E A ++ SALD+LH+ K + +RD Sbjct: 78 EFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHN-KGIAHRD 136 Query: 275 LKLENLMLDKDGH---IKITDFGLCKEGIK--------DGATMKTFCGTPEYLAPEVL-- 321 LK EN++ + +KI DFGL GIK + T CG+ EY+APEV+ Sbjct: 137 LKPENILCEHPNQVSPVKICDFGL-GSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEA 195 Query: 322 ---EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---------------DHEKLFELILM 363 E + Y + D W LGV++Y ++ G PF + LFE I Sbjct: 196 FSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQE 255 Query: 364 EEIRFPRT----LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 + FP + AK L+S LL +D KQRL A +++QH + G Sbjct: 256 GKYEFPDKDWAHISCAAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQGCA 303 >3Q5I-A nrPDB Length = 504 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 82/253 (32%), Positives = 124/253 (49%), Gaps = 20/253 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVI----VAKD----EVAHTLTENRV--LQNS 205 LG G +G+V+L KEK A+K++KK + D E H N + L++ Sbjct: 44 LGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSL 103 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 HP + L F+ V E+ GGELF + F E A +I+S + YLH Sbjct: 104 DHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLH 163 Query: 266 SEKNVVYRDLKLENLMLDKDG---HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 N+V+RD+K EN++L+ +IKI DFGL KD ++ GT Y+APEVL+ Sbjct: 164 KH-NIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKD-YKLRDRLGTAYYIAPEVLK 221 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKS 378 Y D W GV+MY ++CG PF Q+ + + + + + F + + EAK Sbjct: 222 -KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAKE 280 Query: 379 LLSGLLKKDPKQR 391 L+ +L D +R Sbjct: 281 LIKLMLTYDYNKR 293 >3PPZ-A nrPDB Length = 309 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 70/242 (28%), Positives = 122/242 (50%), Gaps = 9/242 (3%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G G+FG V + + G A+KIL ++ A + V L E +++ RHP + Sbjct: 45 IGAGSFGTV--HRAEWHGSDVAVKILMEQDFHA-ERVNEFLREVAIMKRLRHPNIVLFMG 101 Query: 216 SFQTHDRLCFVMEYANGGELF--FHLSRERVFSEDRARFYGA-EIVSALDYLHSEKN-VV 271 + L V EY + G L+ H S R ++R R A ++ ++YLH+ +V Sbjct: 102 AVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIV 161 Query: 272 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVD 331 +RDLK NL++DK +K+ DFGL + + K+ GTPE++APEVL D D Sbjct: 162 HRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSD 221 Query: 332 WWGLGVVMYEMMCGRLPFYNQDHEKLFELI--LMEEIRFPRTLGPEAKSLLSGLLKKDPK 389 + GV+++E+ + P+ N + ++ + + + PR L P+ +++ G +P Sbjct: 222 VYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPW 281 Query: 390 QR 391 +R Sbjct: 282 KR 283 >3COM-A nrPDB Length = 314 Score = 104 bits (260), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 73/262 (27%), Positives = 121/262 (46%), Gaps = 15/262 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F+ L+ LG+G++G V K TG+ A+K +V V D + + E ++Q P Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIK----QVPVESD-LQEIIKEISIMQQCDSPH 85 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYLHSEK 268 + S+ + L VMEY G + + R + +ED + L+YLH + Sbjct: 86 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMR 145 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 + +RD+K N++L+ +GH K+ DFG+ + A T GTP ++APEV+++ Y Sbjct: 146 KI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 204 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---EIRFPRTLGPEAKSLLSGLLK 385 D W LG+ EM G+ P+ + + +I R P + L Sbjct: 205 VADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 264 Query: 386 KDPKQRLGGGSEDAKEIMQHRF 407 K P+QR A +++QH F Sbjct: 265 KSPEQR-----ATATQLLQHPF 281 >4LG4-A nrPDB Length = 299 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 69/263 (26%), Positives = 122/263 (46%), Gaps = 15/263 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F+ L+ LG+G++G V K +G+ A+K + E ++ + E ++Q P+ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE-----SDLQEIIKEISIMQQCDSPY 67 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYLHSEK 268 + S+ + L VMEY G + + R + ED + L+YLH + Sbjct: 68 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 127 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 + +R++K N++L+ +GH K+ DFG+ + A T GTP ++APEV+++ Y Sbjct: 128 KI-HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 186 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---EIRFPRTLGPEAKSLLSGLLK 385 D W LG+ EM G+ P+ + + +I R P + + L Sbjct: 187 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 246 Query: 386 KDPKQRLGGGSEDAKEIMQHRFF 408 K+P+QR A +++QH F Sbjct: 247 KNPEQR-----ATATQLLQHPFI 264 >2UV2-A nrPDB Length = 325 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 73/267 (27%), Positives = 125/267 (46%), Gaps = 18/267 (6%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 +E + LG G FGKV + K T A K++ + +++E+ + E +L + HP Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTK---SEEELEDYMVEIDILASCDHPN 95 Query: 210 LTALKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 + L +F + L ++E+ GG + L ER +E + + + + AL+YLH K Sbjct: 96 IVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNK 155 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-----ED 323 +++RDLK N++ DG IK+ DFG+ + + +F GTP ++APEV+ +D Sbjct: 156 -IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKD 214 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPRTLGPEAKSLL 380 Y D W LG+ + EM P + + ++ I E + P K L Sbjct: 215 RPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFL 274 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRF 407 L+K+ R +++QH F Sbjct: 275 KKCLEKNVDARWT-----TSQLLQHPF 296 >3DLS-A nrPDB Length = 335 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 76/243 (31%), Positives = 119/243 (48%), Gaps = 15/243 (6%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVI-----VAKDEVAHTLTENRVLQNSRHPFL 210 LG G FG V +K + +K +KKE + + ++ E +L H + Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANI 91 Query: 211 TALKYSFQTHDRLCFVME-YANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + F+ VME + +G +LF + R E A + ++VSA+ YL K+ Sbjct: 92 IKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRL-KD 150 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GR 328 +++RD+K EN+++ +D IK+ DFG ++ G TFCGT EY APEVL N Y G Sbjct: 151 IIHRDIKDENIVIAEDFTIKLIDFG-SAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGP 209 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDP 388 ++ W LGV +Y ++ PF E + I P + E SL+SGLL+ P Sbjct: 210 ELEMWSLGVTLYTLVFEENPFCE------LEETVEAAIHPPYLVSKELMSLVSGLLQPVP 263 Query: 389 KQR 391 ++R Sbjct: 264 ERR 266 >6AO5-A nrPDB Length = 362 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 123/263 (46%), Gaps = 15/263 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F+ L+ LG+G++G V K +G+ A+K +V V D + + E ++Q P+ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIK----QVPVESD-LQEIIKEISIMQQCDSPY 66 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYLHSEK 268 + S+ + L VMEY G + + R + ED + L+YLH + Sbjct: 67 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 126 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 + +R++K N++L+ +GH K+ DFG+ + A T GTP ++APEV+++ Y Sbjct: 127 KI-HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 185 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---EIRFPRTLGPEAKSLLSGLLK 385 D W LG+ EM G+ P+ + + +I R P + + L Sbjct: 186 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 245 Query: 386 KDPKQRLGGGSEDAKEIMQHRFF 408 K+P+QR A +++QH F Sbjct: 246 KNPEQR-----ATATQLLQHPFI 263 >3HKO-A nrPDB Length = 345 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 86/307 (28%), Positives = 136/307 (44%), Gaps = 66/307 (21%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVI--VAKDEVAHTLTENRVLQNSRHPFLTAL 213 +G+G++G V + E T A+KI+ K I + +V TE R+++ HP + L Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARL 93 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED------------------------- 248 ++ +C VME +GG L L + VF +D Sbjct: 94 YEVYEDEQYICLVMELCHGGHL---LDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAI 150 Query: 249 RARFYG------------------AEIVSALDYLHSEKNVVYRDLKLENLML--DKDGHI 288 +G +I SAL YLH++ + +RD+K EN + +K I Sbjct: 151 NGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQ-GICHRDIKPENFLFSTNKSFEI 209 Query: 289 KITDFGLCKE--GIKDGA--TMKTFCGTPEYLAPEVLE--DNDYGRAVDWWGLGVVMYEM 342 K+ DFGL KE + +G M T GTP ++APEVL + YG D W GV+++ + Sbjct: 210 KLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLL 269 Query: 343 MCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLKKDPKQRLGGGSED 398 + G +PF + +L +++ F L P A+ LLS LL ++ +R D Sbjct: 270 LMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERF-----D 324 Query: 399 AKEIMQH 405 A +QH Sbjct: 325 AMRALQH 331 >5VO2-A nrPDB Length = 300 Score = 101 bits (251), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 69/249 (27%), Positives = 118/249 (47%), Gaps = 16/249 (6%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 V E L+ +G G G V L GR++ ++ K+V K+ T+ + L+ Sbjct: 9 VPFEEILDLQWVGSGAQGAVFL------GRFHGEEVAVKKVRDLKE------TDIKHLRK 56 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 +HP + K C +ME+ G+L+ L R + + I ++YL Sbjct: 57 LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYL 116 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 H K +++RDLK N+++ D +KI+DFG KE + D +T +F GT ++APEV+ + Sbjct: 117 HLHK-IIHRDLKSPNMLITYDDVVKISDFGTSKE-LSDKSTKMSFAGTVAWMAPEVIRNE 174 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR-TLGPEA-KSLLSG 382 VD W GVV++E++ G +P+ + D + + + P + P+ K LL Sbjct: 175 PVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQ 234 Query: 383 LLKKDPKQR 391 P+ R Sbjct: 235 CWNSKPRNR 243 >6QAU-A nrPDB Length = 280 Score = 101 bits (251), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 82/264 (31%), Positives = 132/264 (50%), Gaps = 23/264 (8%) Query: 146 TMNEFEYLK--LLGKGTFGKVILVKEKATGRY-YAMKILKKEVIVAKDEVAHTLTENRVL 202 + +FEY K L+G G F V + + + A+K + K+ + +K ++ E ++L Sbjct: 7 VVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL-SKSQILLG-KEIKIL 64 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + +H + AL + + + VMEY NGG+L +L + SED R + +I +A+ Sbjct: 65 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 124 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGH---------IKITDFGLCKEGIKDGATMKTFCGTP 313 LHS K +++RDLK +N++L IKI DFG + + CG+P Sbjct: 125 ILHS-KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARY-LHSNMMAADLCGSP 182 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN---QDHEKLFE--LILMEEIRF 368 Y+APEV+ Y D W +G V+Y+ + G+ PF QD +E LM I Sbjct: 183 MYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSI-- 240 Query: 369 PRTLGPEAKSLLSGLLKKDPKQRL 392 PR P +LL GLL+++ K R+ Sbjct: 241 PRETSPYLANLLLGLLQRNQKDRM 264 >4AN9-A nrPDB Length = 301 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 121/263 (46%), Gaps = 11/263 (4%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 66 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P++ +F + + ME+ +GG L L + E ++ L YL + Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 126 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +++RD+K N++++ G IK+ DFG+ + I + A F GT Y++PE L+ Y Sbjct: 127 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMAN--EFVGTRSYMSPERLQGTHYS 184 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME-EIRFPRTL-GPEAKSLLSGLLK 385 D W +G+ + EM GR P +L + I+ E + P + E + ++ L Sbjct: 185 VQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLI 244 Query: 386 KDPKQRLGGGSEDAKEIMQHRFF 408 K+P +R D K++M H F Sbjct: 245 KNPAER-----ADLKQLMVHAFI 262 >6CQF-A nrPDB Length = 297 Score = 99.4 bits (246), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 76/275 (27%), Positives = 131/275 (47%), Gaps = 27/275 (9%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ L+ LG GT+G+V ++K +G A+K++K E D+V+ E +L+ RH Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME---PDDDVSTLQKEILILKTCRH 72 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 + A S+ +L ME+ G L SE + + E++ L YLHS+ Sbjct: 73 ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQ 132 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK---TFCGTPEYLAPEVLE-- 322 K + +RD+K N++++ G +++ DFG+ + GAT+ F GTP ++APEV Sbjct: 133 KKI-HRDIKGANILINDAGEVRLADFGISAQ---IGATLARRLAFIGTPYWMAPEVAAVA 188 Query: 323 -DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRF-PRTLGPEAK--- 377 Y D W LG+ E+ + P + D L L LM + + P L + K Sbjct: 189 LKGGYNELCDIWSLGITAIELAELQPPLF--DVHPLRVLFLMTKSGYQPPRLKEKGKWSA 246 Query: 378 ---SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + + L K PK+R A +++ H+ + Sbjct: 247 AFHNFIKVTLTKSPKKR-----PSATKMLSHQLVS 276 >5L2Q-C nrPDB Length = 320 Score = 99.4 bits (246), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 63/188 (33%), Positives = 100/188 (53%), Gaps = 15/188 (7%) Query: 222 RLCFVMEY----------ANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 R+C V++ A+ L ++ +E+ SE ++V ++ LH +KN+V Sbjct: 117 RICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALH-QKNIV 175 Query: 272 YRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GRA 329 +RDLKL N++L+K H I IT+F L K + +G +K G+P Y++P+VL Y G+ Sbjct: 176 HRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKP 235 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRT--LGPEAKSLLSGLLKKD 387 D W LGVV++ M+ G+ PFY+ ++LF I E P + L+ LL D Sbjct: 236 SDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLD 295 Query: 388 PKQRLGGG 395 P+QRL Sbjct: 296 PQQRLAAA 303 >5KKR-C nrPDB Length = 395 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 99/210 (47%), Gaps = 4/210 (1%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 125 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P++ +F + + ME+ +GG L L + E ++ L YL + Sbjct: 126 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 185 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +++RD+K N++++ G IK+ DFG+ + I A +F GT Y++PE L+ Y Sbjct: 186 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYS 243 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357 D W +G+ + EM GR P D ++L Sbjct: 244 VQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 273 >3EQC-A nrPDB Length = 360 Score = 98.2 bits (243), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 99/210 (47%), Gaps = 4/210 (1%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--QIIRELQVLHECNS 90 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P++ +F + + ME+ +GG L L + E ++ L YL + Sbjct: 91 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 150 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +++RD+K N++++ G IK+ DFG+ + I A +F GT Y++PE L+ Y Sbjct: 151 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYS 208 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357 D W +G+ + EM GR P D ++L Sbjct: 209 VQSDIWSMGLSLVEMAVGRYPIPPPDAKEL 238 >1S9I-A nrPDB Length = 354 Score = 98.2 bits (243), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 101/210 (48%), Gaps = 4/210 (1%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + LG G G V V+ + +G A K++ E+ A + E +VL Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRN--QIIRELQVLHECNS 73 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P++ +F + + ME+ +GG L L + E+ ++ L YL + Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK 133 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +++RD+K N++++ G IK+ DFG+ + I A +F GT Y+APE L+ Y Sbjct: 134 HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMAPERLQGTHYS 191 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357 D W +G+ + E+ GR P D ++L Sbjct: 192 VQSDIWSMGLSLVELAVGRYPIPPPDAKEL 221 >5D7A-A nrPDB Length = 308 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 81/303 (26%), Positives = 133/303 (43%), Gaps = 44/303 (14%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA 188 SGA+E+++S + + FE ++L+G GT+G+V + TG+ A+K++ V Sbjct: 2 SGADEIDLSALRDPAGI----FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD----VT 53 Query: 189 KDEVAHTLTENRVLQNSRHPFLTALKYSF-------QTHDRLCFVMEYANGGEL--FFHL 239 DE E +L+ H A Y D+L VME+ G + Sbjct: 54 GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN 113 Query: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299 ++ E+ + EI+ L +LH K V++RD+K +N++L ++ +K+ DFG+ + Sbjct: 114 TKGNTLKEEWIAYICREILRGLSHLHQHK-VIHRDIKGQNVLLTENAEVKLVDFGVSAQL 172 Query: 300 IKDGATMKTFCGTPEYLAPEVLE-----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354 + TF GTP ++APEV+ D Y D W LG+ EM G P + Sbjct: 173 DRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHP 232 Query: 355 EKLFELILMEEIRFPRTLGPEAK---------SLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 + LI PR P K S + L K+ QR +++M+H Sbjct: 233 MRALFLI-------PRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA-----TEQLMKH 280 Query: 406 RFF 408 F Sbjct: 281 PFI 283 >3ZDU-A nrPDB Length = 325 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 64/201 (31%), Positives = 103/201 (51%), Gaps = 4/201 (1%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +M +E L +G+G++G V+ K K TG+ A+KI + + +++A + E + L+ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIA--MREIKFLKQF 58 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 H L L F+ ++ V E+ + L R R Y +I+ A+DYLH Sbjct: 59 HHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLH 118 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE-VLEDN 324 S N+++RD+K EN+++ + G K+ DFG + G T Y APE VL+D Sbjct: 119 SN-NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDT 177 Query: 325 DYGRAVDWWGLGVVMYEMMCG 345 YG+ VD W LG ++ EM G Sbjct: 178 SYGKPVDIWALGCMIIEMATG 198 >1TKI-A nrPDB Length = 321 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 73/266 (27%), Positives = 129/266 (48%), Gaps = 36/266 (13%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILK---KEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 LG+G FG V E ++ + Y K +K + ++ K E++ +L +RH + Sbjct: 13 LGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEIS-------ILNIARHRNILH 65 Query: 213 LKYSFQTHDRLCFVMEYANGGELF-------FHLSRERVFSEDRARFYGAEIVSALDYLH 265 L SF++ + L + E+ +G ++F F L+ + S Y ++ AL +LH Sbjct: 66 LHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVS------YVHQVCEALQFLH 119 Query: 266 SEKNVVYRDLKLENLMLD--KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 S N+ + D++ EN++ + IKI +FG ++ +K G + PEY APEV + Sbjct: 120 SH-NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQ-LKPGDNFRLLFTAPEYYAPEVHQH 177 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSL 379 + A D W LG ++Y ++ G PF + ++++ E I+ E F + + EA Sbjct: 178 DVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDF 237 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQH 405 + LL K+ K R+ A E +QH Sbjct: 238 VDRLLVKERKSRM-----TASEALQH 258 >6E2O-A nrPDB Length = 295 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 71/247 (28%), Positives = 123/247 (49%), Gaps = 15/247 (6%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTAL 213 +LGKGT+G V ++ + ++I KE+ + L E L ++ +H + Sbjct: 29 VLGKGTYGIVYAGRDLSN----QVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQY 84 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRAR---FYGAEIVSALDYLHSEKNV 270 SF + + ME GG L L + +D + FY +I+ L YLH + + Sbjct: 85 LGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLH-DNQI 143 Query: 271 VYRDLKLENLMLDK-DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN--DYG 327 V+RD+K +N++++ G +KI+DFG K +TF GT +Y+APE+++ YG Sbjct: 144 VHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYG 203 Query: 328 RAVDWWGLGVVMYEMMCGRLPFY--NQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLL 384 +A D W LG + EM G+ PFY + +F++ + + P ++ EAK+ + Sbjct: 204 KAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCF 263 Query: 385 KKDPKQR 391 + DP +R Sbjct: 264 EPDPDKR 270 >2WQN-A nrPDB Length = 310 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 69/255 (27%), Positives = 123/255 (48%), Gaps = 11/255 (4%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 T+ F K +G+G F +V G A+K ++ ++ A + E +L+ Sbjct: 30 TLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL 89 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGEL---FFHLSRERVFSEDRARF-YGAEIVSAL 261 HP + SF + L V+E A+ G+L H +++ +R + Y ++ SAL Sbjct: 90 NHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +++HS + V++RD+K N+ + G +K+ D GL + + GTP Y++PE + Sbjct: 150 EHMHSRR-VMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI-LMEEIRFPRT----LGPEA 376 +N Y D W LG ++YEM + PFY D L+ L +E+ +P E Sbjct: 209 HENGYNFKSDIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIEQCDYPPLPSDHYSEEL 267 Query: 377 KSLLSGLLKKDPKQR 391 + L++ + DP++R Sbjct: 268 RQLVNMCINPDPEKR 282 >4KIK-B nrPDB Length = 677 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 70/216 (32%), Positives = 106/216 (49%), Gaps = 16/216 (7%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 T +E + LG G FG VI + TG A+K ++E+ E E ++++ Sbjct: 17 TCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRE--RWCLEIQIMRRL 74 Query: 206 RHPFLTALK------YSFQTHDRLCFVMEYANGGELFFHLSR-ERV--FSEDRARFYGAE 256 HP + A + + +D MEY GG+L +L++ E E ++ Sbjct: 75 THPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSD 134 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHI---KITDFGLCKEGIKDGATMKTFCGTP 313 I SAL YLH E +++RDLK EN++L + KI D G KE + G+ +F GT Sbjct: 135 IASALRYLH-ENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKE-LDQGSLCTSFVGTL 192 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 +YLAPE+LE Y VD+W G + +E + G PF Sbjct: 193 QYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPF 228 >3DAK-A nrPDB Length = 290 Score = 95.1 bits (235), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 67/237 (28%), Positives = 110/237 (46%), Gaps = 30/237 (12%) Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGG---ELFFHL-----SRERVFSE 247 L E + + HP + + SF D L VM+ +GG ++ H+ + V E Sbjct: 56 LKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDE 115 Query: 248 DRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG----LCKEG-IKD 302 E++ L+YLH + +RD+K N++L +DG ++I DFG L G I Sbjct: 116 STIATILREVLEGLEYLHKNGQI-HRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITR 174 Query: 303 GATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 361 KTF GTP ++APEV+E Y D W G+ E+ G P++ K+ L Sbjct: 175 NKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLT 234 Query: 362 L----------MEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L +++ + G + ++S L+KDP++R A E+++H+FF Sbjct: 235 LQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKR-----PTAAELLRHKFF 286 >5O0Y-A nrPDB Length = 579 Score = 94.7 bits (234), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 81/240 (33%), Positives = 117/240 (48%), Gaps = 32/240 (13%) Query: 174 RYYAMKI--LKKEVIVAKDEV--AHTLTENRVLQNSRHPFLTALK--YSFQTHDRLCFVM 227 RY A+KI L K K E H E R+ + HP + L +S T D C V+ Sbjct: 310 RYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDT-DSFCTVL 368 Query: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEK-NVVYRDLKLENLMLDKD- 285 EY G +L F+L + ++ SE AR +IV+AL YL+ K +++ DLK N++L Sbjct: 369 EYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGT 428 Query: 286 --GHIKITDFGLCKEGIKDGATMKTF---------CGTPEYLAPEVL----EDNDYGRAV 330 G IKITDFGL K I D + + GT YL PE E V Sbjct: 429 ACGEIKITDFGLSK--IMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKV 486 Query: 331 DWWGLGVVMYEMMCGRLPF-YNQDHEKLFE---LILMEEIRFP--RTLGPEAKSLLSGLL 384 D W +GV+ Y+ + GR PF +NQ + + + ++ E++FP + PEAK+ + L Sbjct: 487 DVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCL 546 >4UY9-A nrPDB Length = 323 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 24/263 (9%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL----TENR 200 + E +++G G FGKV + G A+K + + ++++ T+ E + Sbjct: 6 IDFAELTLEEIIGIGGFGKV--YRAFWIGDEVAVKAARHD---PDEDISQTIENVRQEAK 60 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 + +HP + AL+ LC VME+A GG L LS +R+ D + +I Sbjct: 61 LFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRI-PPDILVNWAVQIARG 119 Query: 261 LDYLHSEKNV--VYRDLKLENLMLDK--------DGHIKITDFGLCKEGIKDGATMKTFC 310 ++YLH E V ++RDLK N+++ + + +KITDFGL +E + T + Sbjct: 120 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHR--TTKMSAA 177 Query: 311 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP- 369 GT ++APEV+ + + + D W GV+++E++ G +PF D + + M ++ P Sbjct: 178 GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPI 237 Query: 370 RTLGPEA-KSLLSGLLKKDPKQR 391 + PE L+ DP R Sbjct: 238 PSTCPEPFAKLMEDCWNPDPHSR 260 >4X7Q-B nrPDB Length = 312 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/253 (27%), Positives = 120/253 (47%), Gaps = 19/253 (7%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN-------RV 201 E+ LLGKG FG V A+K++ + ++ ++ ++T +V Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYA-NGGELFFHLSRERVFSEDRARFYGAEIVSA 260 HP + L F+T + V+E +LF +++ + E +R + ++V+A Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 261 LDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 + + HS + VV+RD+K EN+++D + G K+ DFG + F GT Y PE Sbjct: 152 IQHCHS-RGVVHRDIKDENILIDLRRGCAKLIDFG--SGALLHDEPYTDFDGTRVYSPPE 208 Query: 320 VLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378 + + Y W LG+++Y+M+CG +PF +D E IL E+ FP + P+ + Sbjct: 209 WISRHQYHALPATVWSLGILLYDMVCGDIPF-ERDQE-----ILEAELHFPAHVSPDCCA 262 Query: 379 LLSGLLKKDPKQR 391 L+ L P R Sbjct: 263 LIRRCLAPKPSSR 275 >2WTK-C nrPDB Length = 305 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 80/264 (30%), Positives = 126/264 (47%), Gaps = 18/264 (6%) Query: 155 LLGKGTFGKV--ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 LLG+G++GKV +L E R + KK + E A+ E ++L+ RH + Sbjct: 12 LLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGE-ANVKKEIQLLRRLRHKNVIQ 70 Query: 213 LKYSFQTHDR--LCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 L ++ + VMEY G E+ + +R F +A Y +++ L+YLHS+ Sbjct: 71 LVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKR-FPVCQAHGYFCQLIDGLEYLHSQ- 128 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA--TMKTFCGTPEYLAPEVLE--DN 324 +V++D+K NL+L G +KI+ G+ + A T +T G+P + PE+ D Sbjct: 129 GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDT 188 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384 G VD W GV +Y + G PF + KLFE I P GP LL G+L Sbjct: 189 FSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGML 248 Query: 385 KKDPKQRLGGGSEDAKEIMQHRFF 408 + +P +R ++I QH +F Sbjct: 249 EYEPAKRF-----SIRQIRQHSWF 267 >3DTC-A nrPDB Length = 271 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 125/263 (47%), Gaps = 24/263 (9%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL----TENR 200 + E +++G G FGKV + G A+K + + ++++ T+ E + Sbjct: 4 IDFAELTLEEIIGIGGFGKV--YRAFWIGDEVAVKAARHD---PDEDISQTIENVRQEAK 58 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 + +HP + AL+ LC VME+A GG L LS +R+ D + +I Sbjct: 59 LFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRI-PPDILVNWAVQIARG 117 Query: 261 LDYLHSEKNV--VYRDLKLENLMLDK--------DGHIKITDFGLCKEGIKDGATMKTFC 310 ++YLH E V ++RDLK N+++ + + +KITDFGL +E + T + Sbjct: 118 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHR--TTKMSAA 175 Query: 311 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP- 369 G ++APEV+ + + + D W GV+++E++ G +PF D + + M ++ P Sbjct: 176 GAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPI 235 Query: 370 RTLGPEA-KSLLSGLLKKDPKQR 391 + PE L+ DP R Sbjct: 236 PSTCPEPFAKLMEDCWNPDPHSR 258 >5DBX-A nrPDB Length = 328 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 78/289 (26%), Positives = 124/289 (42%), Gaps = 34/289 (11%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVI-VAKDEVAHTLTENRVLQ 203 + + +E +++G G V K A+K + E + DE+ L E + + Sbjct: 8 ICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDEL---LKEIQAMS 64 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS--------RERVFSEDRARFYGA 255 HP + SF D L VM+ +GG + + + V E Sbjct: 65 QCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK 124 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG----LCKEG-IKDGATMKTFC 310 E++ LDYLH + +RDLK N++L +DG ++I DFG L G + K F Sbjct: 125 EVLEGLDYLHRNGQI-HRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFV 183 Query: 311 GTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL------- 362 GTP ++APEV+E Y D W G+ E+ G P++ K+ L L Sbjct: 184 GTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTL 243 Query: 363 ---MEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +E+ + G + LLS L+KDP +R A E+++ +FF Sbjct: 244 ETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKR-----PTAAELLKCKFF 287 >4GS6-A nrPDB Length = 315 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 80/280 (28%), Positives = 131/280 (46%), Gaps = 27/280 (9%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 H + E E +++G+G FG ++ K K + A+K ++ E E + E R L Sbjct: 4 HMIDYKEIEVEEVVGRGAFG--VVCKAKWRAKDVAIKQIESE-----SERKAFIVELRQL 56 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVS 259 HP + L + + +C VMEYA GG L+ L ++ A + + Sbjct: 57 SRVNHPNIVKLYGA--CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 260 ALDYLHS--EKNVVYRDLKLENLMLDKDGHI-KITDFGLCKEGIKDGATMKTFCGTPEYL 316 + YLHS K +++RDLK NL+L G + KI DFG M G+ ++ Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG---TACDIQTHMTNNKGSAAWM 171 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI--LMEEIRFP--RTL 372 APEV E ++Y D + G++++E++ R PF ++ F ++ + R P + L Sbjct: 172 APEVFEGSNYSEKCDVFSWGIILWEVITRRKPF-DEIGGPAFRIMWAVHNGTRPPLIKNL 230 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH--RFFAG 410 +SL++ KDP QR E+ +IM H R+F G Sbjct: 231 PKPIESLMTRCWSKDPSQR--PSMEEIVKIMTHLMRYFPG 268 >3QA8-A nrPDB Length = 676 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 69/216 (31%), Positives = 103/216 (47%), Gaps = 16/216 (7%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 T +E + LG G FG V+ + TG A+K ++E+ E E ++++ Sbjct: 12 TCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRE--RWCLEIQIMKKL 69 Query: 206 RHPFLTALK------YSFQTHDRLCFVMEYANGGELFFHLSR-ERV--FSEDRARFYGAE 256 HP + + + +D MEY GG+L +L++ E E R ++ Sbjct: 70 NHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSD 129 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHI---KITDFGLCKEGIKDGATMKTFCGTP 313 I SAL YLH E +++RDLK EN++L KI D G KE + G F GT Sbjct: 130 ISSALRYLH-ENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKE-LDQGELCTEFVGTL 187 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 +YLAPE+LE Y VD+W G + +E + G PF Sbjct: 188 QYLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >5HI2-A nrPDB Length = 283 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 71/248 (28%), Positives = 123/248 (49%), Gaps = 23/248 (9%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G G+FG V K K G + +++ K+EV VL+ +RH + L Sbjct: 28 IGSGSFGTV--YKGKWHGDVAVKMLTPQQLQAFKNEVG-------VLRKTRHVNIL-LFM 77 Query: 216 SFQTHDRLCFVMEYANGGELFFHL-SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 + T +L V ++ G L+ HL + E F + + +DYLH+ K++++RD Sbjct: 78 GYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHA-KSIIHRD 136 Query: 275 LKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPEVL---EDNDYGRA 329 LK N+ L +D +KI DFGL K + G+ ++APEV+ + N Y Sbjct: 137 LKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQ 196 Query: 330 VDWWGLGVVMYEMMCGRLPFYN-QDHEKLFELI----LMEEIRFPRTLGPE-AKSLLSGL 383 D + G+V+YE+M G+LP+ N + +++ E++ L ++ R+ P+ K L++ Sbjct: 197 SDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAEC 256 Query: 384 LKKDPKQR 391 LKK +R Sbjct: 257 LKKKRDER 264 >4UYA-A nrPDB Length = 340 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 109/224 (48%), Gaps = 17/224 (7%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT-EN 199 P H V E +L+G G FG+V + G+ A+K +++ A ++ E Sbjct: 20 PVH-VAFERLELKELIGAGGFGQV--YRATWQGQEVAVKAARQDPEQDAAAAAESVRREA 76 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 R+ RHP + L+ LC V+E+A GG L L+ R+ + +I Sbjct: 77 RLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAGRRIPPHVLVN-WAVQIAR 135 Query: 260 ALDYLHSEKNV--VYRDLKLEN-LMLDKDGH-------IKITDFGLCKEGIKDGATMKTF 309 + YLH E V ++RDLK N L+L+K H +KITDFGL +E + T Sbjct: 136 GMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHR--TTKMAT 193 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353 G ++APEV++ + + + D W GV+++E++ G +P+ D Sbjct: 194 AGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGID 237 >2BRG-A nrPDB Length = 297 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 110/208 (52%), Gaps = 10/208 (4%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK-KEVIVAKDEVAHTLTENRVLQNS 205 + +++ ++ LG+G +G+V L + T A+KI+ K + + + + N++L + Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHE 65 Query: 206 RHPFLTALKYSFQTHDRLCFV-MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 Y + + ++ +EY +GGELF + + E A+ + ++++ + YL Sbjct: 66 N----VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL 121 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG--ATMKTFCGTPEYLAPEVLE 322 H + +RD+K ENL+LD+ ++KI+DFGL + + CGT Y+APE+L+ Sbjct: 122 HG-IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180 Query: 323 DNDY-GRAVDWWGLGVVMYEMMCGRLPF 349 ++ VD W G+V+ M+ G LP+ Sbjct: 181 RREFHAEPVDVWSCGIVLTAMLAGELPW 208 >5CEK-A nrPDB Length = 263 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 55/177 (31%), Positives = 92/177 (51%), Gaps = 11/177 (6%) Query: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299 SR+R+ E+ AR + +IVSA+ + H + +V DLKL + + ++ L Sbjct: 93 SRKRLREEEAARLF-KQIVSAVAHCH-QSAIVLGDLKLRKFVFSTEERTQLRLESLEDTH 150 Query: 300 IKDGA--TMKTFCGTPEYLAPEVLEDND--YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 I G + G P Y++PE+L G+A D W LGV++Y ++ GR PF++ D Sbjct: 151 IMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPS 210 Query: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 LF I + P + P+A+ L+ LL+++P +RL A EI+ H +F ++ Sbjct: 211 ALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-----TAPEILLHPWFESVL 262 >6DC0-A nrPDB Length = 292 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 55/177 (31%), Positives = 92/177 (51%), Gaps = 11/177 (6%) Query: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299 SR+R+ E+ AR + +IVSA+ + H + +V DLKL + + ++ L Sbjct: 90 SRKRLREEEAARLF-KQIVSAVAHCH-QSAIVLGDLKLRKFVFSTEERTQLRLESLEDTH 147 Query: 300 IKDGA--TMKTFCGTPEYLAPEVLEDND--YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 I G + G P Y++PE+L G+A D W LGV++Y ++ GR PF++ D Sbjct: 148 IMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPS 207 Query: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 LF I + P + P+A+ L+ LL+++P +RL A EI+ H +F ++ Sbjct: 208 ALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-----TAPEILLHPWFESVL 259 >5B2L-A nrPDB Length = 324 Score = 87.8 bits (216), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 69/266 (25%), Positives = 126/266 (47%), Gaps = 13/266 (4%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 +++ +++ +N+ E L +G GT G+V ++ + TG A+K +++ K+E Sbjct: 5 LTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSG--NKEENKRI 62 Query: 196 LTE-NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYG 254 L + + VL++ P++ +F T+ + ME + E Sbjct: 63 LMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMT 122 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE 314 IV AL YL + V++RD+K N++LD+ G IK+ DFG+ + A ++ G Sbjct: 123 VAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAA 181 Query: 315 YLAPEVLE-----DNDYGRAVDWWGLGVVMYEMMCGRLPFYN--QDHEKLFELILMEEIR 367 Y+APE ++ DY D W LG+ + E+ G+ P+ N D E L +++ E Sbjct: 182 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPL 241 Query: 368 FPRTLG--PEAKSLLSGLLKKDPKQR 391 P +G + +S + L KD ++R Sbjct: 242 LPGHMGFSGDFQSFVKDCLTKDHRKR 267 >4U41-A nrPDB Length = 332 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 19/252 (7%) Query: 123 GSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK 182 GS +D+ +++ L+ + + FE ++++G GT+G+V + TG+ A+K++ Sbjct: 1 GSANDSPAKSLVDIDLSSLRDPAGI--FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 58 Query: 183 KEVIVAKDEVAHTLTENRVLQNSRHPFLTA-----LKYSFQTHD-RLCFVMEYANGGEL- 235 + +E L N + + S H + +K S HD +L VME+ G + Sbjct: 59 ---VTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSIT 115 Query: 236 -FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 ++ ED + EI+ L +LH +V++RD+K +N++L ++ +K+ DFG Sbjct: 116 DLVKNTKGNTLKEDWIAYISREILRGLAHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFG 174 Query: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLE-----DNDYGRAVDWWGLGVVMYEMMCGRLPF 349 + + + TF GTP ++APEV+ D Y D W G+ EM G P Sbjct: 175 VSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPL 234 Query: 350 YNQDHEKLFELI 361 + + LI Sbjct: 235 CDMHPMRALFLI 246 >4EWQ-A nrPDB Length = 383 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 112/222 (50%), Gaps = 18/222 (8%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK---EVIVAKDEVAHTLTENRVLQNSR 206 ++ L +G G +G V + TG A+K L + +I AK T E R+L++ + Sbjct: 47 YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK----RTYRELRLLKHMK 102 Query: 207 HPFLTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 H + L F L +++ + G +L ++ + + ++D +F +I+ L Sbjct: 103 HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQILRGL 161 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 Y+HS ++++RDLK NL +++D +KI DFGL + + M + T Y APE++ Sbjct: 162 KYIHS-ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIM 217 Query: 322 ED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 362 + Y + VD W +G +M E++ GR F DH +LIL Sbjct: 218 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIL 259 >5TQX-A nrPDB Length = 655 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 89/302 (29%), Positives = 135/302 (44%), Gaps = 46/302 (15%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL-- 213 LG G FG V L + + A+K + E+ E E ++++ H + Sbjct: 16 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRE--RWCHEIQIMKKLNHANVVKACD 73 Query: 214 ---KYSFQTHDRLCFVMEYANGGELFFHLSRERV---FSEDRARFYGAEIVSALDYLHSE 267 + + HD MEY +GG+L L++ E + ++I S + YLH E Sbjct: 74 VPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLH-E 132 Query: 268 KNVVYRDLKLENLML-DKDGHI--KITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 +++RDLK EN++L D G I KI D G K+ + G F GT +YLAPE+ E+ Sbjct: 133 NKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKD-VDQGELCTEFVGTLQYLAPELFENK 191 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQD-----HEK--------LFELILME-EIRFPR 370 Y VD+W G +++E + G PF + HEK +F M E+RF Sbjct: 192 PYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSS 251 Query: 371 TLGPEAKSL-----------LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEK 419 L P+ SL L +L DP+QR GG D + Q R F ++ H+ Sbjct: 252 HL-PQPNSLCSLIVEPMENWLQLMLNWDPQQR--GGPVDLT-LKQPRCF--VLMDHILNL 305 Query: 420 KL 421 K+ Sbjct: 306 KI 307 >4AGU-A nrPDB Length = 311 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 82/300 (27%), Positives = 135/300 (45%), Gaps = 45/300 (15%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMK-ILKKEVIVAKDEVAHTLTENRVLQNS 205 M ++E + +G+G++G V + + TG+ A+K L+ E ++A L E R+L+ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIA--LREIRMLKQL 59 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 +HP L L F+ RL V EY + L +R E + + + A+++ H Sbjct: 60 KHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH 119 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-EDN 324 N ++RD+K EN+++ K IK+ DFG + T Y +PE+L D Sbjct: 120 KH-NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFY--NQDHEKLF-------ELIL------------- 362 YG VD W +G V E++ G +P + D ++L+ +LI Sbjct: 179 QYGPPVDVWAIGCVFAELLSG-VPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFS 237 Query: 363 ---------ME--EIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 ME E++FP P A LL G L DP +RL ++++ H +F I Sbjct: 238 GVKIPDPEDMEPLELKFPNISYP-ALGLLKGCLHMDPTERLT-----CEQLLHHPYFENI 291 >2XNP-A nrPDB Length = 279 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 105/212 (49%), Gaps = 16/212 (7%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 ++E L +G G++G+ ++ K+ G+ K L + + E ++E +L+ +HP Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSM-TEAEKQMLVSEVNLLRELKHP 65 Query: 209 FLTALKYSFQTHDR----LCFVMEYANGGELFFHLSR----ERVFSEDRARFYGAEIVSA 260 ++Y + DR L VMEY GG+L +++ + E+ ++ A Sbjct: 66 --NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123 Query: 261 LDYLHSEKN----VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 316 L H + V++RDLK N+ LD ++K+ DFGL + D + KTF GTP Y+ Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYM 183 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP 348 +PE + Y D W LG ++YE +C +P Sbjct: 184 SPEQMNRMSYNEKSDIWSLGCLLYE-LCALMP 214 >4IC8-A nrPDB Length = 442 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 72/303 (23%), Positives = 142/303 (46%), Gaps = 48/303 (15%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +E+E ++ +G G +G V + + TG+ A+K + V + TL E ++L++ +H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN-AKRTLRELKILKHFKH 113 Query: 208 PFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + A+K + + +V+ +L + + + + R++ +++ L Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLK 173 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDF----GLCKEGIKDGATMKTFCGTPEYLAP 318 Y+HS + V++RDLK NL+++++ +KI DF GLC + M + T Y AP Sbjct: 174 YMHSAQ-VIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 232 Query: 319 EV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-------------- 363 E+ L ++Y +A+D W +G + EM+ R F +++ +LI+M Sbjct: 233 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 292 Query: 364 -EEIR-FPRTLGP---------------EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406 E +R + ++L P +A SLL +L+ +P R+ + ++H Sbjct: 293 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAA-----LRHP 347 Query: 407 FFA 409 F A Sbjct: 348 FLA 350 >4ZSG-A nrPDB Length = 347 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 72/303 (23%), Positives = 142/303 (46%), Gaps = 48/303 (15%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +E+E ++ +G G +G V + + TG+ A+K + V + TL E ++L++ +H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN-AKRTLRELKILKHFKH 65 Query: 208 PFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + A+K + + +V+ +L + + + + R++ +++ L Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLK 125 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDF----GLCKEGIKDGATMKTFCGTPEYLAP 318 Y+HS + V++RDLK NL+++++ +KI DF GLC + M + T Y AP Sbjct: 126 YMHSAQ-VIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 319 EV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-------------- 363 E+ L ++Y +A+D W +G + EM+ R F +++ +LI+M Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 244 Query: 364 -EEIR-FPRTLGP---------------EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406 E +R + ++L P +A SLL +L+ +P R+ + ++H Sbjct: 245 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAA-----LRHP 299 Query: 407 FFA 409 F A Sbjct: 300 FLA 302 >4BBM-A nrPDB Length = 331 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 67/234 (28%), Positives = 120/234 (51%), Gaps = 18/234 (7%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMK-ILKKEVIVAKDEVAHTLTENRVLQN 204 +M ++E L L+G+G++G V+ + K TGR A+K L+ + ++A + E ++L+ Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIA--MREIKLLKQ 80 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGG-----ELFFHLSRERVFSEDRARFYGAEIVS 259 RH L L + R V E+ + ELF + +V + Y +I++ Sbjct: 81 LRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQK-----YLFQIIN 135 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 + + HS N+++RD+K EN+++ + G +K+ DFG + G T Y APE Sbjct: 136 GIGFCHSH-NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPE 194 Query: 320 VL-EDNDYGRAVDWWGLGVVMYEMMCGRLPFY--NQDHEKLFELILMEEIRFPR 370 +L D YG+AVD W +G ++ EM G P + + D ++L+ +++ PR Sbjct: 195 LLVGDVKYGKAVDVWAIGCLVTEMFMGE-PLFPGDSDIDQLYHIMMCLGNLIPR 247 >5O2C-A nrPDB Length = 380 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 112/221 (50%), Gaps = 17/221 (7%) Query: 198 ENRVLQNSRHPFLTALKYSFQT--HDRLCFVM--EYANGGELFFHLSRERVFSEDRARFY 253 E +L+ +HP + S+++ + C V+ E G L +L R +V R + Sbjct: 74 EAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSW 133 Query: 254 GAEIVSALDYLHSEKN-VVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCG 311 +I+ L +LH+ +++RDLK +N+ + G +KI D GL + + K+ G Sbjct: 134 CRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT--LMRTSFAKSVIG 191 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN-QDHEKLFELIL--MEEIRF 368 TPE++APE+ E++ Y +VD + G+ M EM P+ Q+ +++ + ++ F Sbjct: 192 TPEFMAPEMYEEH-YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASF 250 Query: 369 PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + PE K ++ G ++++ +RL ++++ H FFA Sbjct: 251 NKVTDPEVKEIIEGCIRQNKSERLS-----IRDLLNHAFFA 286 >3M42-A nrPDB Length = 299 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 73/252 (28%), Positives = 114/252 (45%), Gaps = 39/252 (15%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 ++LG G GKV+ + K T +A+K+L+ + A+ EV ++ R + Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVELHWRASQCPHIVR--IVDVY 80 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 + + L VME +GGELF + ++ F+E A I A+ YLHS N+ Sbjct: 81 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-INIA 139 Query: 272 YRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 +RD+K ENL+ + +K+TDFG KE + Y + Sbjct: 140 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE----------------------KYDK 177 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIRFPRT----LGPEAKSLL 380 + D W LGV+MY ++CG PFY+ + I M + FP + E K L+ Sbjct: 178 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 237 Query: 381 SGLLKKDPKQRL 392 LLK +P QR+ Sbjct: 238 RNLLKTEPTQRM 249 >4QNY-A nrPDB Length = 354 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 85/320 (26%), Positives = 146/320 (45%), Gaps = 29/320 (9%) Query: 137 SLAKPKHRVTMNEFEYL--KLLGKGTFGKVILVKE-KATGRYYAMKILKKE----VIVAK 189 SLA+ + V + YL +++G G++G VI ++ K+ R AMK + KE VI+AK Sbjct: 7 SLAELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAK 66 Query: 190 DEVAHTLTENRVLQNSRHPFLTALKYSF-----QTHDRLCFVMEYANGGELFFHLSRERV 244 L E ++L + + L+ + D VM+ +L L + Sbjct: 67 ----RILREIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQE 121 Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 304 +E +F+ + + AL +HS V++RD+ N++++ + +KI DFGL KE G Sbjct: 122 LTEAHIQFFIYQALRALHIIHS-AGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGE 180 Query: 305 TMKTFCGTPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 363 M + Y APE V+ED DY +D WG+G ++ E++ R F +D + I+ Sbjct: 181 YMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIV- 239 Query: 364 EEIRFP--RTLGPEAKSLLSGLLKK-------DPKQRLGGGSEDAKEIMQHRFFAGIVWQ 414 + I P + S LKK D +QR S +A ++++H + Sbjct: 240 DVIGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRR 299 Query: 415 HVYEKKLSPPFKPQVTSETD 434 + + PF Q+ + D Sbjct: 300 ITVLQAMRHPFLEQLHDDAD 319 >4IDT-A nrPDB Length = 356 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 79/281 (28%), Positives = 130/281 (46%), Gaps = 22/281 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQNSRHPFLTALK 214 LG+G+FG+V +++K TG A+K ++ EV A++ +A LT R++ P A++ Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIV-----PLYGAVR 136 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 + ME GG L + + EDRA +Y + + L+YLHS + +++ D Sbjct: 137 EGPWVN----IFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHS-RRILHGD 191 Query: 275 LKLENLMLDKDG-HIKITDFG----LCKEGI-KDGATMKTFCGTPEYLAPEVLEDNDYGR 328 +K +N++L DG H + DFG L +G+ KD T GT ++APEV+ Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDA 251 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME--EIR-FPRTLGPEAKSLLSGLLK 385 VD W +M M+ G P+ L I E +R P + P + L+ Sbjct: 252 KVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLR 311 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAGI--VWQHVYEKKLSPP 424 K+P R+ K + G+ W+ Y++ PP Sbjct: 312 KEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPP 352 >5HIE-A nrPDB Length = 302 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 71/248 (28%), Positives = 122/248 (49%), Gaps = 23/248 (9%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G G+FG V K K G + +++ K+EV VL+ +RH + L Sbjct: 44 IGSGSFGTV--YKGKWHGDVAVKMLTPQQLQAFKNEVG-------VLRKTRHVNIL-LFM 93 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 + T +L V ++ G L+ HL E F + + +DYLH+ K++++RD Sbjct: 94 GYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA-KSIIHRD 152 Query: 275 LKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPEVL---EDNDYGRA 329 LK N+ L +D +KI DFGL K + G+ ++APEV+ + N Y Sbjct: 153 LKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQ 212 Query: 330 VDWWGLGVVMYEMMCGRLPFYN-QDHEKLFELI----LMEEIRFPRTLGPEA-KSLLSGL 383 D + G+V+YE+M G+LP+ N + +++ ++ L ++ R+ P+A K L++ Sbjct: 213 SDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAEC 272 Query: 384 LKKDPKQR 391 LKK +R Sbjct: 273 LKKKRDER 280 >5O2B-A nrPDB Length = 285 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 112/221 (50%), Gaps = 17/221 (7%) Query: 198 ENRVLQNSRHPFLTALKYSFQT--HDRLCFVM--EYANGGELFFHLSRERVFSEDRARFY 253 E +L+ +HP + S+++ + C V+ E G L +L R +V R + Sbjct: 65 EAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSW 124 Query: 254 GAEIVSALDYLHSEKN-VVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCG 311 +I+ L +LH+ +++RDLK +N+ + G +KI D GL + + K+ G Sbjct: 125 CRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT--LMRTSFAKSVIG 182 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN-QDHEKLFELIL--MEEIRF 368 TPE++APE+ E++ Y +VD + G+ M EM P+ Q+ +++ + ++ F Sbjct: 183 TPEFMAPEMYEEH-YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASF 241 Query: 369 PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + PE K ++ G ++++ +RL ++++ H FFA Sbjct: 242 NKVTDPEVKEIIEGCIRQNKSERL-----SIRDLLNHAFFA 277 >2BPM-A nrPDB Length = 309 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 81/302 (26%), Positives = 138/302 (45%), Gaps = 46/302 (15%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQ 203 V M F+ ++ +G+GT+G V + K TG A+K ++ + + V T + E +L+ Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLK 61 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSALD 262 HP + L T ++L V E+ + + F S + Y +++ L Sbjct: 62 ELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPE 319 + HS + V++RDLK +NL+++ +G IK+ DFGL + G ++T+ T Y APE Sbjct: 122 FCHSHR-VLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLWYRAPE 177 Query: 320 VLEDND-YGRAVDWWGLGVVMYEMMCGRLPFY-NQDHEKLFELILM----EEIRFPRT-- 371 +L Y AVD W LG + EM+ R F + + ++LF + +E+ +P Sbjct: 178 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237 Query: 372 ----------------------LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 L + +SLLS +L DP +R+ AK + H FF Sbjct: 238 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQ 292 Query: 410 GI 411 + Sbjct: 293 DV 294 >4BGQ-A nrPDB Length = 304 Score = 85.1 bits (209), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 107/214 (50%), Gaps = 9/214 (4%) Query: 137 SLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT- 195 S+ P MN+FE L ++G+G +G V+ + K T A+K K +EV T Sbjct: 1 SMKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSE--ENEEVKETT 58 Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 L E ++L+ + + LK +F+ +L V EY L ++ + Y Sbjct: 59 LRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIY 118 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK---EGIKDGATMKTFCGT 312 +++ A+ + H + ++V+RD+K ENL++ + +K+ DFG + EG + A T Sbjct: 119 QLIKAIHWCH-KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEG--NNANYDEEVAT 175 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346 Y +PE+L YG++VD W +G ++ E+ G+ Sbjct: 176 RWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQ 209 >4TPT-A nrPDB Length = 303 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 64/211 (30%), Positives = 96/211 (45%), Gaps = 26/211 (12%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQNSRHPFLTA 212 ++LGKG FG+ I V KATG+ MK E+I +E T LTE +V+++ HP + Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMK----ELIRCDEETQKTFLTEVKVMRSLDHPNVLK 61 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272 +L + EY GG L L F + + I S + YLHS +++ Sbjct: 62 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHS-MCIIH 120 Query: 273 RDLKLENLMLDKDGHIKITDFGLC-------KEGIKDGATMK-------------TFCGT 312 RDL N ++ D + + DFGL K + AT K T G Sbjct: 121 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343 P ++APE+L Y VD + G+V+ E++ Sbjct: 181 PYWMAPEMLNGKSYDETVDIFSFGIVLCEII 211 >1UA2-A nrPDB Length = 346 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 99/209 (47%), Gaps = 5/209 (2%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILK-KEVIVAKDEVAHT-LTENRVLQNSRH 207 +E L LG+G F V ++K T + A+K +K AKD + T L E ++LQ H Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L +F + V ++ V + + Y + L+YLH + Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH-Q 130 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-EDNDY 326 +++RDLK NL+LD++G +K+ DFGL K T Y APE+L Y Sbjct: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 G VD W +G ++ E++ R+PF D + Sbjct: 191 GVGVDMWAVGCILAELLL-RVPFLPGDSD 218 >4KRC-A nrPDB Length = 317 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 77/305 (25%), Positives = 135/305 (44%), Gaps = 54/305 (17%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++F+ L+ LG GT+ V K TG Y A+K +K + A + E +++ +H Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA--IREISLMKELKH 62 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-----RVFSEDRARFYGAEIVSALD 262 + L T ++L V E+ + + SR R + +++ +++ L Sbjct: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPE 319 + H E +++RDLK +NL+++K G +K+ DFGL + G + TF T Y AP+ Sbjct: 123 FCH-ENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRAPD 178 Query: 320 VLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL---------------- 362 VL + Y ++D W G ++ EM+ G+ F + E+ +LI Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 Query: 363 ---------------MEEIRFPRTLGPEAKSL---LSGLLKKDPKQRLGGGSEDAKEIMQ 404 + ++ P T P +L L GLL+ +P RL AK+ + Sbjct: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALH 293 Query: 405 HRFFA 409 H +FA Sbjct: 294 HPWFA 298 >5HVK-A nrPDB Length = 315 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 109/225 (48%), Gaps = 22/225 (9%) Query: 139 AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LT 197 ++P ++ + ++LGKG FG+ I V + TG MK E+I +E T L Sbjct: 5 SRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMK----ELIRFDEETQRTFLK 60 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL-SRERVFSEDRARFYGAE 256 E +V++ HP + RL F+ EY GG L + S + + + + + Sbjct: 61 EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKD 120 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK---------EGIK-----D 302 I S + YLHS N+++R+L N ++ ++ ++ + DFGL + EG++ D Sbjct: 121 IASGMAYLHS-MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPD 179 Query: 303 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347 T G P ++APE++ Y VD + G+V+ E++ GR+ Sbjct: 180 RKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRV 223 >1CM8-A nrPDB Length = 367 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 95/344 (27%), Positives = 147/344 (42%), Gaps = 38/344 (11%) Query: 122 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL 181 S P SG EV+ + R + L+ +G G +G V + TG A+K L Sbjct: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRD---LQPVGSGAYGAVCSAVDGRTGAKVAIKKL 58 Query: 182 KKEV---IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLC----FVMEYANGGE 234 + + AK E R+L++ RH + L F + L F + G Sbjct: 59 YRPFQSELFAK----RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT 114 Query: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 L + EDR +F +++ L Y+H+ +++RDLK NL +++D +KI DFG Sbjct: 115 DLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVNEDCELKILDFG 173 Query: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353 L ++ + M + T Y APEV+ + Y + VD W +G +M EM+ G+ F D Sbjct: 174 LARQA---DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 Query: 354 HEKLFELILMEEIRFP-----RTLGPEAKSLLSGLL---KKDPKQRLGGGSEDAKEIM-- 403 H + I+ P R EAK+ + GL KKD L S A ++ Sbjct: 231 HLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEK 290 Query: 404 ------QHRFFAGIVWQHVYEKKL-SPPFKPQVTSETDTRYFDE 440 + R AG H Y + L +PQV D+ FD+ Sbjct: 291 MLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDS--FDD 332 >5ZTN-A nrPDB Length = 429 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 66/247 (26%), Positives = 120/247 (48%), Gaps = 23/247 (9%) Query: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168 GL ++ + M +G P +N G ++ + S + H +E LK++GKG+FG+V+ Sbjct: 62 GLNAKKRQGM---TGGP-NNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY 117 Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ--------NSRHPFLTALKYSFQTH 220 + ++ A+K+++ E K E R+L+ N+ + ++F+ H Sbjct: 118 DHKVHQHVALKMVRNE----KRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNH 173 Query: 221 DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENL 280 + F + N EL ++ + FS R + I+ LD LH + +++ DLK EN+ Sbjct: 174 ICMTFELLSMNLYEL-IKKNKFQGFSLPLVRKFAHSILQCLDALHKNR-IIHCDLKPENI 231 Query: 281 MLDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVV 338 +L + G IK+ DFG + + T+ + Y APEV+ YG +D W LG + Sbjct: 232 LLKQQGRSGIKVIDFG---SSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCI 288 Query: 339 MYEMMCG 345 + E++ G Sbjct: 289 LAELLTG 295 >3OHT-A nrPDB Length = 389 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 110/222 (49%), Gaps = 18/222 (8%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK---EVIVAKDEVAHTLTENRVLQNSR 206 ++ L +G G +G V + +G A+K L + +I AK T E R+L++ + Sbjct: 53 YQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAK----RTYRELRLLKHMK 108 Query: 207 HPFLTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 H + L F L +++ + G +L ++ + + ++D +F +I+ L Sbjct: 109 HENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQILRGL 167 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 Y+HS ++++RDLK NL +++D +KI DFGL + + M + T Y APE++ Sbjct: 168 KYIHS-ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIM 223 Query: 322 ED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 362 + Y VD W +G +M E++ GR F DH + I+ Sbjct: 224 LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIM 265 >1U5R-A nrPDB Length = 348 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 92/207 (44%), Gaps = 8/207 (3%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F L+ +G G+FG V ++ A+K + + ++ + E R LQ RHP Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + + VMEY G ++ E + L YLHS N Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH-N 174 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV---LEDNDY 326 +++RD+K N++L + G +K+ DFG A +F GTP ++APEV +++ Y Sbjct: 175 MIHRDVKAGNILLSEPGLVKLGDFG----SASIMAPANSFVGTPYWMAPEVILAMDEGQY 230 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQD 353 VD W LG+ E+ + P +N + Sbjct: 231 DGKVDVWSLGITCIELAERKPPLFNMN 257 >4HVI-A nrPDB Length = 314 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 66/205 (32%), Positives = 98/205 (47%), Gaps = 18/205 (8%) Query: 150 FEYLKLLGKGTFGKVILVKEKA----TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +Y+ LGKG FG V L + TG A+K L+ D+ E ++L+ Sbjct: 12 LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS---GPDQQRDFQREIQILKAL 68 Query: 206 RHPFLTALKYSFQTH----DRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSA 260 F+ +KY ++ L VMEY G L L R R R Y ++I Sbjct: 69 HSDFI--VKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKG 126 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEY-LA 317 ++YL S + V+RDL N++++ + H+KI DFGL K KD ++ +P + A Sbjct: 127 MEYLGS-RRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYA 185 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEM 342 PE L DN + R D W GVV+YE+ Sbjct: 186 PESLSDNIFSRQSDVWSFGVVLYEL 210 >5VD3-A nrPDB Length = 311 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 78/249 (31%), Positives = 119/249 (47%), Gaps = 14/249 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKD---EVAHTLTENRVLQN 204 F+ L LG G++G+V V+ K GR YA+K KD ++A + +V Q Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ- 115 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL-SRERVFSEDRARFYGAEIVSALDY 263 HP L+ +++ L E G L H + E + Y + + AL + Sbjct: 116 --HPCCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAH 172 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LHS+ +V+ D+K N+ L G K+ DFGL E GA + G P Y+APE+L+ Sbjct: 173 LHSQ-GLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAG-EVQEGDPRYMAPELLQ- 229 Query: 324 NDYGRAVDWWGLGVVMYEMMCG-RLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 YG A D + LG+ + E+ C LP + ++L + L E F L E +S+L Sbjct: 230 GSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPE--FTAGLSSELRSVLVM 287 Query: 383 LLKKDPKQR 391 +L+ DPK R Sbjct: 288 MLEPDPKLR 296 >2GCD-A nrPDB Length = 309 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 92/207 (44%), Gaps = 8/207 (3%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F L+ +G G+FG V ++ A+K + + ++ + E R LQ RHP Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + + VMEY G ++ E + L YLHS N Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH-N 135 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV---LEDNDY 326 +++RD+K N++L + G +K+ DFG A +F GTP ++APEV +++ Y Sbjct: 136 MIHRDVKAGNILLSEPGLVKLGDFG----SASIMAPANSFVGTPYWMAPEVILAMDEGQY 191 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQD 353 VD W LG+ E+ + P +N + Sbjct: 192 DGKVDVWSLGITCIELAERKPPLFNMN 218 >2PMN-X nrPDB Length = 348 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 72/307 (23%), Positives = 136/307 (44%), Gaps = 53/307 (17%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 +N++ ++ L +G F K+IL ++ ++YA+K +K ++ K + + + +++ Sbjct: 30 INDYRIIRTLNQGKFNKIILCEK--DNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 207 HPFLTALKYSFQTHDRLCFVME--YANGGELFF---HLSRERVFSEDRARF-----YGA- 255 F L+ + C E N E++ ++ + + D F Y Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 256 -----------EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 304 ++++ Y+H+EKN+ +RD+K N+++DK+G +K++DFG + + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMV--DK 205 Query: 305 TMKTFCGTPEYLAPEVL--EDNDYGRAVDWWGLGVVMYEMMCGRLPF-YNQDHEKLFELI 361 +K GT E++ PE E + G VD W LG+ +Y M +PF +LF I Sbjct: 206 KIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNI 265 Query: 362 LMEEIRFP-------------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 402 + I +P L E L L+K+P +R+ SEDA Sbjct: 266 RTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERI--TSEDA--- 320 Query: 403 MQHRFFA 409 ++H + A Sbjct: 321 LKHEWLA 327 >2A1A-B nrPDB Length = 284 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 72/256 (28%), Positives = 126/256 (49%), Gaps = 21/256 (8%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK-------KEV-IVAKDEVAHTLTENR 200 +F+ ++L+G G FG+V K + G+ Y +K +K +EV +AK + + + N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNG 71 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFV-MEYANGGELFFHLSRERVFSEDR--ARFYGAEI 257 + T+ K S ++ + F+ ME+ + G L + + R D+ A +I Sbjct: 72 CWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQI 131 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 +DY+HS+K ++ RDLK N+ L +KI DFGL DG ++ GT Y++ Sbjct: 132 TKGVDYIHSKK-LINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMS 189 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMM--CGRLPFYNQDHEKLFELILMEEIRFPRTLGPE 375 PE + DYG+ VD + LG+++ E++ C ++ L + I+ + + Sbjct: 190 PEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISD------IFDKK 243 Query: 376 AKSLLSGLLKKDPKQR 391 K+LL LL K P+ R Sbjct: 244 EKTLLQKLLSKKPEDR 259 >3QUP-A nrPDB Length = 323 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 74/264 (28%), Positives = 122/264 (46%), Gaps = 25/264 (9%) Query: 149 EFEYLKLLGKGTFGKV---ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +F ++LGKG FG V L +E + A+K+LK ++I + D + L E ++ Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSD-IEEFLREAACMKEF 82 Query: 206 RHPF---LTALKYSFQTHDRL---CFVMEYANGGELFFHLSRERVFS-------EDRARF 252 HP L + + RL ++ + G+L L R+ + RF Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT 312 +I ++YL S +N ++RDL N ML +D + + DFGL ++ I G + C + Sbjct: 143 M-VDIACGMEYL-SSRNFIHRDLAARNCMLAEDMTVCVADFGLSRK-IYSGDYYRQGCAS 199 Query: 313 P---EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFE-LILMEEIR 367 ++LA E L DN Y D W GV M+E+M G+ P+ ++ +++ LI ++ Sbjct: 200 KLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLK 259 Query: 368 FPRTLGPEAKSLLSGLLKKDPKQR 391 P E L+ DPKQR Sbjct: 260 QPPECMEEVYDLMYQCWSADPKQR 283 >3VN9-A nrPDB Length = 340 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 71/284 (25%), Positives = 131/284 (46%), Gaps = 19/284 (6%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 +S+ V ++ E + LG+G +G V ++ +G+ A+K ++ V ++++ Sbjct: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV-NSQEQKRLL 97 Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH---LSRERVFSEDRARF 252 + + ++ PF + + ME + F+ + + + ED Sbjct: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF-CG 311 IV AL++LHS+ +V++RD+K N++++ G +K+ DFG+ G + KT G Sbjct: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI--SGYLVDSVAKTIDAG 215 Query: 312 TPEYLAPEVL--EDNDYGRAV--DWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEE 365 Y+APE + E N G +V D W LG+ M E+ R P+ + ++L +++ Sbjct: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 275 Query: 366 IRFPR-TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + P E S LKK+ K+R E+MQH FF Sbjct: 276 PQLPADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 >2F9G-A nrPDB Length = 353 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 78/310 (25%), Positives = 131/310 (42%), Gaps = 60/310 (19%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++F+ LLG+G +G V K TG A+K K E TL E ++L++ +H Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLREIKILKHFKH 68 Query: 208 PFLTAL-----KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + + SF+ + + + E + ++ S+D +++ + + A+ Sbjct: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK---EGIKDGAT-------MKTFCGT 312 LH NV++RDLK NL+++ + +K+ DFGL + E D + M + T Sbjct: 127 VLHGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 Query: 313 PEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--------- 362 Y APEV L Y RA+D W G ++ E+ R F +D+ LI Sbjct: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Query: 363 -----MEEIR-------------------FPRTLGPEAKSLLSGLLKKDPKQRLGGGSED 398 +E R FPR + P+ LL +L DP +R+ Sbjct: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-VNPKGIDLLQRMLVFDPAKRIT----- 299 Query: 399 AKEIMQHRFF 408 AKE ++H + Sbjct: 300 AKEALEHPYL 309 >6DTL-A nrPDB Length = 364 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 104/219 (47%), Gaps = 9/219 (4%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +GKG +G V T A+K + K + TL E ++L++ H + A++ Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIAN-AFDNKIDAKRTLREIKLLRHMDHENIVAIRD 96 Query: 216 SFQTHDRLCFVMEYAN----GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 R F Y +L + + SE+ +++ +I+ L Y+HS NV+ Sbjct: 97 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS-ANVL 155 Query: 272 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE-VLEDNDYGRAV 330 +RDLK NL+L+ + +KI DFGL + + M + T Y APE +L +DY A+ Sbjct: 156 HRDLKPSNLLLNANCDLKICDFGLARVT-SESDFMTEYVVTRWYRAPELLLNSSDYTAAI 214 Query: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369 D W +G + E+M + F +DH L LME I P Sbjct: 215 DVWSVGCIFMELMDRKPLFPGRDHVHQLRL-LMELIGTP 252 >4PWN-A nrPDB Length = 274 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 108/220 (49%), Gaps = 16/220 (7%) Query: 198 ENRVLQNSRHPFLTALKYSFQTHDR----LCFVMEYANGGELFFHLSRERVFSEDRARFY 253 E +L+ +HP + S+++ + + V E G L +L R +V R + Sbjct: 59 EAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSW 118 Query: 254 GAEIVSALDYLHSEKN-VVYRDLKLENLMLDK-DGHIKITDFGLCKEGIKDGATMKTFCG 311 +I+ L +LH+ +++RDLK +N+ + G +KI D GL K + K+ G Sbjct: 119 CRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLE-KRASFAKSVIG 177 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN-QDHEKLFELIL--MEEIRF 368 TPE++APE+ E+ Y +VD + G+ M EM P+ Q+ +++ + ++ F Sbjct: 178 TPEFMAPEMYEEK-YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASF 236 Query: 369 PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + PE K ++ G ++++ +R K+++ H FF Sbjct: 237 DKVAIPEVKEIIEGCIRQNKDERY-----SIKDLLNHAFF 271 >4X3F-A nrPDB Length = 337 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 99/218 (45%), Gaps = 10/218 (4%) Query: 140 KPKHRVTMN-EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 P+ VT++ + +L+ G G+V + GR A+K+LK E + + E Sbjct: 3 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 62 Query: 199 NRVLQNSRHPFLTAL----KYSFQTHDRLCF-VMEYANGGELFFHLSRERVFSEDRARFY 253 R HP + ++ + R + VME NG L L R S A Sbjct: 63 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 122 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT--FCG 311 + AL H+ +V+RD+K N+++ G +KITDFG+ K + +T G Sbjct: 123 LEQTGRALQIAHAA-GLVHRDVKPGNILITPTGQVKITDFGIAKA-VDAAPVTQTGMVMG 180 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 T +Y+APE +D A D + LGVV YE + G+ PF Sbjct: 181 TAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPF 218 >4OW8-A nrPDB Length = 283 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 99/218 (45%), Gaps = 10/218 (4%) Query: 140 KPKHRVTMN-EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 P+ VT++ + +L+ G G+V + GR A+K+LK E + + E Sbjct: 2 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 61 Query: 199 NRVLQNSRHPFLTAL----KYSFQTHDRLCF-VMEYANGGELFFHLSRERVFSEDRARFY 253 R HP + ++ + R + VME NG L L R S A Sbjct: 62 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 121 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT--FCG 311 + AL H+ +V+RD+K N+++ G +KITDFG+ K + +T G Sbjct: 122 LEQTGRALQIAHA-AGLVHRDVKPGNILITPTGQVKITDFGIAKA-VDAAPVTQTGMVMG 179 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 T +Y+APE +D A D + LGVV YE + G+ PF Sbjct: 180 TAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPF 217 >1ZXE-A nrPDB Length = 303 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 72/286 (25%), Positives = 133/286 (46%), Gaps = 52/286 (18%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + +LG+G FG+V+ + RYYA+K ++ +++++ L+E +L + H Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH----TEEKLSTILSEVMLLASLNH 61 Query: 208 PFLTALKYSFQTHDRLCFV---------------MEYANGGELFFHLSRERVFSEDRARF 252 ++ ++Y +R FV MEY L+ + E + ++ R + Sbjct: 62 QYV--VRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENL-NQQRDEY 118 Query: 253 YGA--EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE------------ 298 + +I+ AL Y+HS+ +++R+LK N+ +D+ ++KI DFGL K Sbjct: 119 WRLFRQILEALSYIHSQ-GIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDS 177 Query: 299 ----GIKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYN-Q 352 G D T + GT Y+A EVL+ Y +D + LG++ +EM+ PF Sbjct: 178 QNLPGSSDNLT--SAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGM 232 Query: 353 DHEKLFELILMEEIRFPRTLGPEA----KSLLSGLLKKDPKQRLGG 394 + + + + I FP K ++ L+ DP +R G Sbjct: 233 ERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGA 278 >5G6V-A nrPDB Length = 324 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/241 (27%), Positives = 108/241 (44%), Gaps = 17/241 (7%) Query: 152 YLKL--LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA--HTLTENRVLQNSRH 207 Y+KL LG+GT+ V K K T A+ KE+ + +E A + E +L++ +H Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVAL----KEIRLEHEEGAPCTAIREVSLLKDLKH 59 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 + L T L V EY + + + + + + +++ L Y H + Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 119 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV-LEDNDY 326 K V++RDLK +NL++++ G +K+ DFGL + T T Y P++ L DY Sbjct: 120 K-VLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDY 178 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 +D WG+G + YEM GR F E+ I R LG + G+L Sbjct: 179 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIF-------RILGTPTEETWPGILSN 231 Query: 387 D 387 + Sbjct: 232 E 232 >5AMN-A nrPDB Length = 299 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 79/290 (27%), Positives = 134/290 (46%), Gaps = 24/290 (8%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVIL-----VKEKATGRYYAMKILKKEVIVAKDEV 192 L PK K LG+G FGKV+ +K +A A+K+LK+ + E+ Sbjct: 13 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSEL 70 Query: 193 AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSR--------E 242 L+E VL+ HP + L + L ++EYA G L F SR E Sbjct: 71 RDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDE 130 Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD 302 R + + +I + YL +E +V+RDL N+++ + +KI+DFGL ++ ++ Sbjct: 131 RALTMGDLISFAWQISQGMQYL-AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE 189 Query: 303 GATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM-CGRLPFYNQDHEKLFE 359 + +K G +++A E L D+ Y D W GV+++E++ G P+ E+LF Sbjct: 190 DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN 249 Query: 360 LILM-EEIRFPRTLGPEAKSLLSGLLKKDPKQR--LGGGSEDAKEIMQHR 406 L+ + P E L+ K++P +R S+D +++M R Sbjct: 250 LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR 299 >5X5O-A nrPDB Length = 310 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/254 (25%), Positives = 116/254 (45%), Gaps = 19/254 (7%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 ++ ++ ++ + G G+FG V K + + A+K L K I + E+ L+ ++Q Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK--IEKEAEILSVLSHRNIIQ 68 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEIVSAL 261 L Y V EYA+ G L+ +++ R D + ++ + Sbjct: 69 -FYGVILEPPNYGI--------VTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGM 119 Query: 262 DYLHSEK--NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 YLH E V++RDLK N+++ DG +KI DFG + + T + GT ++APE Sbjct: 120 HYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR--FHNHTTHMSLVGTFPWMAPE 177 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFPRTLGPEAK 377 V++ D + GVV++EM+ +PF + ++ L++ E + P + Sbjct: 178 VIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFA 237 Query: 378 SLLSGLLKKDPKQR 391 LL + D K+R Sbjct: 238 ELLHQCWEADAKKR 251 >3OMV-A nrPDB Length = 307 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/200 (31%), Positives = 101/200 (50%), Gaps = 12/200 (6%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G G+FG V K K G A+KILK V ++ E VL+ +RH + L Sbjct: 44 IGSGSFGTV--YKGKWHGDV-AVKILK-VVDPTPEQFQAFRNEVAVLRKTRHVNIL-LFM 98 Query: 216 SFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 + T D L V ++ G L+ HL +E F + + +DYLH+ KN+++RD Sbjct: 99 GYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHA-KNIIHRD 157 Query: 275 LKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPEVL---EDNDYGRA 329 +K N+ L + +KI DFGL K ++ G+ ++APEV+ ++N + Sbjct: 158 MKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ 217 Query: 330 VDWWGLGVVMYEMMCGRLPF 349 D + G+V+YE+M G LP+ Sbjct: 218 SDVYSYGIVLYELMTGELPY 237 >1K9A-A nrPDB Length = 450 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 99/210 (47%), Gaps = 17/210 (8%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQ 203 + M E + L+ +GKG FG V+L G Y K+ K + D A L E V+ Sbjct: 190 LNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVK--CIKNDATAQAFLAEASVMT 241 Query: 204 NSRHPFLTAL-KYSFQTHDRLCFVMEYANGGELFFHL-SRER-VFSEDRARFYGAEIVSA 260 RH L L + L V EY G L +L SR R V D + ++ A Sbjct: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 ++YL N V+RDL N+++ +D K++DFGL KE +T T ++ APE Sbjct: 302 MEYLEG-NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEA 357 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 349 L + + D W G++++E+ GR+P+ Sbjct: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPY 387 >1BYG-A nrPDB Length = 278 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 99/210 (47%), Gaps = 17/210 (8%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQ 203 + M E + L+ +GKG FG V+L G Y K+ K + D A L E V+ Sbjct: 18 LNMKELKLLQTIGKGEFGDVML------GDYRGNKVAVK--CIKNDATAQAFLAEASVMT 69 Query: 204 NSRHPFLTAL-KYSFQTHDRLCFVMEYANGGELFFHL-SRER-VFSEDRARFYGAEIVSA 260 RH L L + L V EY G L +L SR R V D + ++ A Sbjct: 70 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 129 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 ++YL N V+RDL N+++ +D K++DFGL KE +T T ++ APE Sbjct: 130 MEYLEG-NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWTAPEA 185 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 349 L + + D W G++++E+ GR+P+ Sbjct: 186 LREKKFSTKSDVWSFGILLWEIYSFGRVPY 215 >6B2Q-A nrPDB Length = 317 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 99/218 (45%), Gaps = 10/218 (4%) Query: 140 KPKHRVTMN-EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 P+ VT++ + +L+ G G+V + GR A+K+LK E + + E Sbjct: 23 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 82 Query: 199 NRVLQNSRHPFLTAL----KYSFQTHDRLCF-VMEYANGGELFFHLSRERVFSEDRARFY 253 R HP + ++ + R + VME NG L L R S A Sbjct: 83 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 142 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT--FCG 311 + AL H+ +V+RD+K N+++ G +KITDFG+ K + +T G Sbjct: 143 LEQTGRALQIAHA-AGLVHRDVKPGNILITPTGQVKITDFGIAKA-VDAAPVTQTGMVMG 200 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 T +Y+APE +D A D + LGVV YE + G+ PF Sbjct: 201 TAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPF 238 >4Y93-A nrPDB Length = 446 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 67/226 (29%), Positives = 112/226 (49%), Gaps = 12/226 (5%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 + +LK LG G FG V K + G+Y + KE +++DE + E +V+ N H Sbjct: 189 DLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEF---IEEAKVMMNLSHE 243 Query: 209 FLTALKYSFQTHDRLCFVM-EYANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYLHS 266 L L Y T R F++ EY G L +L R F + ++ A++YL S Sbjct: 244 KLVQL-YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 302 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDND 325 K ++RDL N +++ G +K++DFG+ + + D T T P ++ +PEVL + Sbjct: 303 -KQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSK 361 Query: 326 YGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPR 370 + D W GV+M+E+ G++P+ + + E I + +R PR Sbjct: 362 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI-AQGLRLPR 406 >4YFF-A nrPDB Length = 311 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 103/217 (47%), Gaps = 12/217 (5%) Query: 141 PKH-RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199 P H + ++E E+ +++G G+FGKV K + + A+K + +K +V E Sbjct: 34 PSHFHLQLSEIEFHEIIGSGSFGKV--YKGRCRNKIVAIKRYRANTYCSKSDVDMFCREV 91 Query: 200 RVLQNSRHPFLTA-LKYSFQTHDRLCFVMEYANGGELFFHL-SRERVFSEDRARFYGAEI 257 +L HP + + + V +Y +GG LF L ++R+ ++ Sbjct: 92 SILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDV 151 Query: 258 VSALDYLHS-EKNVVYRDLKLENLMLDKDGHIKITDFG---LCKEGIKDGATMKTFCGTP 313 ++YLH+ + +++RDL N++L +DGH + DFG + +D T + G Sbjct: 152 AKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQP--GNL 209 Query: 314 EYLAPEVL-EDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 ++APEV + Y D + + ++E++ G +PF Sbjct: 210 RWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >3FME-A nrPDB Length = 290 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 69/274 (25%), Positives = 127/274 (46%), Gaps = 17/274 (6%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 V ++ E + LG+G +G V ++ +G+ A+K ++ V ++++ + + ++ Sbjct: 4 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV-NSQEQKRLLMDLDISMRT 62 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH---LSRERVFSEDRARFYGAEIVSAL 261 PF + + ME + F+ + + + ED IV AL Sbjct: 63 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 122 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 ++LHS+ +V++RD+K N++++ G +K+ DFG+ + D A G Y+APE + Sbjct: 123 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAK-DIDAGCKPYMAPERI 181 Query: 322 --EDNDYGRAV--DWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEEIRFPR-TLGP 374 E N G +V D W LG+ M E+ R P+ + ++L +++ + P Sbjct: 182 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA 241 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 E S LKK+ K+R E+MQH FF Sbjct: 242 EFVDFTSQCLKKNSKER-----PTYPELMQHPFF 270 >2XYN-A nrPDB Length = 292 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 69/245 (28%), Positives = 112/245 (45%), Gaps = 18/245 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG G +G+V + K A+K LK++ + EV L E V++ +HP L L Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLG 95 Query: 216 SFQTHDRLCFVMEYANGGELFFHL---SRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272 V EY G L +L +RE V + + +I SA++YL +KN ++ Sbjct: 96 VCTLEPPFYIVTEYMPYGNLLDYLRECNREEV-TAVVLLYMATQISSAMEYLE-KKNFIH 153 Query: 273 RDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVD 331 RDL N ++ ++ +K+ DFGL + D T P ++ APE L N + D Sbjct: 154 RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD 213 Query: 332 WWGLGVVMYEMMC-GRLPFYNQDHEKLFELI----LMEEIRFPRTLGPEAKSLLSGLLKK 386 W GV+++E+ G P+ D ++++L+ ME+ P P+ L+ K Sbjct: 214 VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ---PEGCPPKVYELMRACWKW 270 Query: 387 DPKQR 391 P R Sbjct: 271 SPADR 275 >6J5U-C nrPDB Length = 426 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 72/228 (31%), Positives = 98/228 (42%), Gaps = 19/228 (8%) Query: 149 EFEYLKLLGKGTFGKV---------ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199 F LLG+G FG V + +G A+K LK E E LTE Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEW---LTEV 141 Query: 200 RVLQNSRHPFLTAL-KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 L HP L L Y + +RL V E+ G L HL R A + Sbjct: 142 NYLGQLSHPNLVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVG 200 Query: 259 SA--LDYLHSEKN-VVYRDLKLENLMLDKDGHIKITDFGLCKEG-IKDGATMKT-FCGTP 313 +A L +LH K+ V+YRD K N++LD D + K++DFGL K G D + T GT Sbjct: 201 AAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 361 Y APE + D + GVV+ E++ GR N + + L+ Sbjct: 261 GYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV 308 >2WO6-A nrPDB Length = 382 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 109/220 (49%), Gaps = 20/220 (9%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK-KEVIVAKDEVAHTLTENRVLQNS 205 M+ +E L+GKG+FG+V+ ++ + A+KI+K K+ + + ++ L E L N Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLE---LMNK 109 Query: 206 RHP----FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF---SEDRARFYGAEIV 258 ++ LK F + LC V E + + L R F S + R + ++ Sbjct: 110 HDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYN--LYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 259 SALDYLHS-EKNVVYRDLKLENLML--DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEY 315 +AL +L + E ++++ DLK EN++L K IKI DFG + G + + + Y Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFG---SSCQLGQRIYQYIQSRFY 224 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 +PEVL Y A+D W LG ++ EM G P ++ +E Sbjct: 225 RSPEVLLGMPYDLAIDMWSLGCILVEMHTGE-PLFSGANE 263 >6GU6-A nrPDB Length = 302 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 140/300 (46%), Gaps = 49/300 (16%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQN 204 +M ++ ++ +G+GT+G V + K TG+ AMK ++ E ++ V T + E +L+ Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKE 62 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALD 262 RHP + +L+ RL + E+ + + + + + Y +I+ + Sbjct: 63 LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPE 319 + HS + V++RDLK +NL++D G IK+ DFGL + G ++ + T Y +PE Sbjct: 123 FCHSRR-VLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPE 178 Query: 320 VLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE--KLFELIL------------ME 364 VL + Y VD W +G + E+ + P ++ D E +LF + +E Sbjct: 179 VLLGSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 237 Query: 365 EIR-----FPR----TLGPEAKS-------LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 ++ FP+ +L K+ LLS +L DP +R+ G K + H +F Sbjct: 238 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYF 292 >3ORP-A nrPDB Length = 311 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 105/222 (47%), Gaps = 16/222 (7%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 + P H + +E ++LG G +V L ++ R A+K+L+ ++ A+D + L Sbjct: 4 MTTPSH--LSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADL--ARDP-SFYLR 58 Query: 198 ENRVLQNS---RHPFLTALKYSFQTHDRLC----FVMEYANGGELFFHLSRERVFSEDRA 250 R QN+ HP + A+ + + VMEY +G L + E + RA Sbjct: 59 FRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRA 118 Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM---K 307 A+ AL++ H + +++RD+K N+M+ +K+ DFG+ + G ++ Sbjct: 119 IEVIADACQALNFSH-QNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTA 177 Query: 308 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 GT +YL+PE + D + LG V+YE++ G PF Sbjct: 178 AVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPF 219 >5FM2-A nrPDB Length = 355 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 87/343 (25%), Positives = 151/343 (44%), Gaps = 56/343 (16%) Query: 117 EMDFRSGS---PSDNSGAEEMEVSLAKPKHRVTMNEFEYL---------------KLLGK 158 EM FR + P S + SL +++V+++ F+ L K LG+ Sbjct: 15 EMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGE 74 Query: 159 GTFGKVIL-----VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 G FGKV+ +K +A A+K+LK+ + E+ L+E VL+ HP + L Sbjct: 75 GEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLSEFNVLKQVNHPHVIKL 132 Query: 214 KYSFQTHDRLCFVMEYANGGEL--FFHLSR----------------------ERVFSEDR 249 + L ++EYA G L F SR ER + Sbjct: 133 YGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGD 192 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309 + +I + YL +E +V+RDL N+++ + +KI+DFGL ++ ++ + +K Sbjct: 193 LISFAWQISQGMQYL-AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS 251 Query: 310 CG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EE 365 G +++A E L D+ Y D W GV+++E++ G P+ E+LF L+ Sbjct: 252 QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHR 311 Query: 366 IRFPRTLGPEAKSLLSGLLKKDPKQR--LGGGSEDAKEIMQHR 406 + P E L+ K++P +R S+D +++M R Sbjct: 312 MERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR 354 >3LLT-A nrPDB Length = 360 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 76/259 (29%), Positives = 117/259 (45%), Gaps = 53/259 (20%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI---LKKEVIVAKDEVAHTLTENRVLQN 204 N F ++ +G GTFG+V+L + +YYA+K+ +KK AK E A L + +QN Sbjct: 35 NAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIE-ADILKK---IQN 90 Query: 205 SRHPFLTALKY--SFQTHDRLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEIVSA 260 +KY F +D +C + E G L+ ++R F + + Y EI+ A Sbjct: 91 DDINNNNIVKYHGKFMYYDHMCLIFE-PLGPSLYEIITRNNYNGFHIEDIKLYCIEILKA 149 Query: 261 LDYLHSEKNVVYRDLKLENLMLD-------------------------KDGHIKITDFGL 295 L+YL + ++ + DLK EN++LD K IK+ DFG Sbjct: 150 LNYL-RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGC 208 Query: 296 CKEGIKDGATMK-----TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350 AT K + T +Y APEV+ + + + D W G V+ E+ G L F Sbjct: 209 --------ATFKSDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLF- 259 Query: 351 NQDHEKLFELILMEEIRFP 369 + HE + L +ME I P Sbjct: 260 -RTHEHMEHLAMMESIIQP 277 >3ALO-A nrPDB Length = 327 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/277 (22%), Positives = 127/277 (45%), Gaps = 21/277 (7%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 T + + L +G+G +G V + K +G+ A+K ++ V K++ + + V+++S Sbjct: 20 TAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV-DEKEQKQLLMDLDVVMRSS 78 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGG----ELFFHLSRERVFSEDRARFYGAEIVSAL 261 P++ + ME + + + + V E+ V AL Sbjct: 79 DCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKAL 138 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 ++L +++RD+K N++LD+ G+IK+ DFG+ + + A + G Y+APE + Sbjct: 139 NHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRD-AGCRPYMAPERI 197 Query: 322 EDN----DYGRAVDWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEEIRFP----RT 371 + + Y D W LG+ +YE+ GR P+ +N ++L +++ + + R Sbjct: 198 DPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEERE 257 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 P + ++ L KD +R KE+++H F Sbjct: 258 FSPSFINFVNLCLTKDESKR-----PKYKELLKHPFI 289 >3UIU-A nrPDB Length = 306 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 71/270 (26%), Positives = 126/270 (46%), Gaps = 36/270 (13%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL------------ 196 +F+ ++L+G G FG+V K + G+ Y ++ +K A+ EV Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAEREVKALAKLDHVNIVHYNG 72 Query: 197 ----------TENRVLQNSRHPFLTALKYSFQTHDRLCFV-MEYANGGELFFHLSRERVF 245 T + L++S + + K S ++ + F+ ME+ + G L + + R Sbjct: 73 CWDGFDYDPETSDDSLESSDYDPENS-KNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGE 131 Query: 246 SEDR--ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG 303 D+ A +I +DY+HS+K +++RDLK N+ L +KI DFGL DG Sbjct: 132 KLDKVLALELFEQITKGVDYIHSKK-LIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDG 190 Query: 304 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM--CGRLPFYNQDHEKLFELI 361 ++ GT Y++PE + DYG+ VD + LG+++ E++ C ++ L + I Sbjct: 191 KRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGI 249 Query: 362 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 + + + K+LL LL K P+ R Sbjct: 250 ISD------IFDKKEKTLLQKLLSKKPEDR 273 >6CTH-A nrPDB Length = 309 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 8/207 (3%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +VT N F LG+G FG V + + Y A+K + + +K + +E +++ Sbjct: 12 KVTSN-FNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSR---ASKQGIKEYASEVKIIS 67 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF-YGAEIVSALD 262 RH L L L V E+ G L H+ + + R+ ++ SAL Sbjct: 68 RLRHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALL 127 Query: 263 YLHSEKN--VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT-FCGTPEYLAPE 319 YLH E + V++RD+K N+MLD + K+ DFGL + KT GT Y+APE Sbjct: 128 YLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPE 187 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGR 346 L + D + GVV E+ GR Sbjct: 188 CLSSGKASKESDVYSFGVVALEIASGR 214 >4G3E-A nrPDB Length = 352 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 101/201 (50%), Gaps = 17/201 (8%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQNSRHPFLTALK 214 +G+G+FG+V +K+K TG A+K ++ EV ++ VA L+ R++ P A++ Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAGLSSPRIV-----PLYGAVR 136 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 + ME GG L + + EDRA +Y + + L+YLH+ + +++ D Sbjct: 137 EGPWVN----IFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHT-RRILHGD 191 Query: 275 LKLENLMLDKDG-HIKITDFG--LCKEGIKDGATMKT---FCGTPEYLAPEVLEDNDYGR 328 +K +N++L DG + DFG LC + G ++ T GT ++APEV+ Sbjct: 192 VKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDA 251 Query: 329 AVDWWGLGVVMYEMMCGRLPF 349 VD W +M M+ G P+ Sbjct: 252 KVDIWSSCCMMLHMLNGCHPW 272 >3E3P-A nrPDB Length = 360 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 74/266 (27%), Positives = 123/266 (46%), Gaps = 35/266 (13%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 + A + R M+ F+ ++ G+GTFG V L KEK+TG A+K + ++ E+ Sbjct: 11 AAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNREL-QI 69 Query: 196 LTENRVLQNSRHPFLTALK---YSFQTHDR----LCFVMEYANGGELFFHLSRERVFSED 248 + + VL HP + L+ Y+ DR L VMEY H + Sbjct: 70 MQDLAVLH---HPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDT---LHRCCRNYYRRQ 123 Query: 249 RA------RFYGAEIVSALDYLH-SEKNVVYRDLKLENLMLDK-DGHIKITDFGLCKEGI 300 A + + +++ ++ LH NV +RD+K N+++++ DG +K+ DFG K+ Sbjct: 124 VAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS 183 Query: 301 KDGATMKTFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE--KL 357 + C Y APE++ N Y AVD W +G + EMM G P + D+ +L Sbjct: 184 PSEPNVAYICSR-YYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGE-PIFRGDNSAGQL 241 Query: 358 FELILMEEIRFPRTLGPEAKSLLSGL 383 E++ R LG ++ +L L Sbjct: 242 HEIV--------RVLGCPSREVLRKL 259 >4CSV-A nrPDB Length = 275 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 63/256 (24%), Positives = 114/256 (44%), Gaps = 12/256 (4%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K + +E + LG G FG+V K + A+K LK+ + V L E ++ Sbjct: 5 KWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTM----SVEEFLQEAQI 60 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL--SRERVFSEDRARFYGAEIVS 259 ++ +HP L L + + EY + G L +L + A++ S Sbjct: 61 MKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVAS 120 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAP 318 + YL S+ N ++RDL N ++ ++ +K+ DFGL + +D T + P ++ AP Sbjct: 121 GMAYLESQ-NFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAP 179 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLG--PE 375 E + N + D W G++++E+ G++P+ ++ E + R PR G E Sbjct: 180 EAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQV-ERGYRMPRPQGCPEE 238 Query: 376 AKSLLSGLLKKDPKQR 391 L+ K P++R Sbjct: 239 IYELMLQCWNKSPEER 254 >5TOS-A nrPDB Length = 395 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 69/238 (28%), Positives = 105/238 (44%), Gaps = 28/238 (11%) Query: 133 EMEVSLAKPKHRVTMNEFEYL-------KLLGKGTFGKV---------ILVKEKATGRYY 176 E E+ + P T NE + ++G+G FG V + + TG Sbjct: 43 EGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVI 102 Query: 177 AMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL-KYSFQTHDRLCFVMEYANGGEL 235 A+K L +E E LTE L HP L L Y + RL V E+ G L Sbjct: 103 AVKKLNQEGFQGHRE---WLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSL 158 Query: 236 FFHLSRERVFSEDRARFYGAEIV----SALDYLHSEK-NVVYRDLKLENLMLDKDGHIKI 290 HL R + + F + L +LHS+ V+YRD+K N++LD D + K+ Sbjct: 159 ENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKL 218 Query: 291 TDFGLCKEG-IKDGATMKT-FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346 +DFGL ++G + D + + T GT Y APE + D + GV++ E++ G+ Sbjct: 219 SDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 >5TUR-A nrPDB Length = 404 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 68/257 (26%), Positives = 123/257 (47%), Gaps = 27/257 (10%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH---TLTENRVLQN 204 ++++ LLG G FG V + A+K ++K+ I E+ + E +L+ Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 205 SRHPFLTALKYS--FQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSAL 261 F ++ F+ D ++E + F ER E+ AR + +++ A+ Sbjct: 187 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 246 Query: 262 DYLHSEKNVVYRDLKLENLMLDKD-GHIKITDFGLCKEGIKDGATMKT-----FCGTPEY 315 + H+ V++RD+K EN+++D + G +K+ DFG GA +K F GT Y Sbjct: 247 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFG-------SGALLKDTVYTDFDGTRVY 298 Query: 316 LAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGP 374 PE + + Y GR+ W LG+++Y+M+CG +PF +H+ E I+ ++ F + + Sbjct: 299 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---EHD---EEIIRGQVFFRQRVSS 352 Query: 375 EAKSLLSGLLKKDPKQR 391 E + L+ L P R Sbjct: 353 ECQHLIRWCLALRPSDR 369 >4MYG-A nrPDB Length = 372 Score = 74.7 bits (182), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 82/321 (25%), Positives = 135/321 (42%), Gaps = 67/321 (20%) Query: 128 NSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV-- 185 N A E+ + P H +G G +G V +K +G A+K L + Sbjct: 35 NKTAWELPKTYVSPTH------------VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS 82 Query: 186 -IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV 244 I AK L +L++ +H + L F L ++ F +++ Sbjct: 83 EIFAKRAYRELL----LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMP-FMQTDLQKI 137 Query: 245 ----FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300 FSE++ ++ +++ L Y+HS VV+RDLK NL +++D +KI DFGL + Sbjct: 138 MGMEFSEEKIQYLVYQMLKGLKYIHS-AGVVHRDLKPGNLAVNEDCELKILDFGLARHA- 195 Query: 301 KDGATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH-EKLF 358 A M + T Y APEV L Y + VD W +G +M EM+ G+ F +D+ ++L Sbjct: 196 --DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLT 253 Query: 359 ELILMEEI-------------------------------RFPRTLGPEAKSLLSGLLKKD 387 +++ + + FPR P+A LL +L+ D Sbjct: 254 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA-SPQAADLLEKMLELD 312 Query: 388 PKQRLGGGSEDAKEIMQHRFF 408 +RL A + + H FF Sbjct: 313 VDKRL-----TAAQALTHPFF 328 >4RC3-A nrPDB Length = 289 Score = 74.7 bits (182), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 68/257 (26%), Positives = 123/257 (47%), Gaps = 27/257 (10%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH---TLTENRVLQN 204 ++++ LLG G FG V + A+K ++K+ I E+ + E +L+ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 205 SRHPFLTALKYS--FQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSAL 261 F ++ F+ D ++E + F ER E+ AR + +++ A+ Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 131 Query: 262 DYLHSEKNVVYRDLKLENLMLDKD-GHIKITDFGLCKEGIKDGATMKT-----FCGTPEY 315 + H+ V++RD+K EN+++D + G +K+ DFG GA +K F GT Y Sbjct: 132 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFG-------SGALLKDTVYTDFDGTRVY 183 Query: 316 LAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGP 374 PE + + Y GR+ W LG+++Y+M+CG +PF +H+ E I+ ++ F + + Sbjct: 184 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---EHD---EEIIRGQVFFRQRVSS 237 Query: 375 EAKSLLSGLLKKDPKQR 391 E + L+ L P R Sbjct: 238 ECQHLIRWCLALRPSDR 254 >6NPU-A nrPDB Length = 298 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 79/279 (28%), Positives = 124/279 (44%), Gaps = 27/279 (9%) Query: 120 FRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMK 179 + GSP N EME + KH+ LG G +G+V K A+K Sbjct: 11 YFQGSP--NYDKWEMERTDITMKHK-----------LGGGQYGEVYEGVWKKYSLTVAVK 57 Query: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239 LK++ + EV L E V++ +HP L L + E+ G L +L Sbjct: 58 TLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL 113 Query: 240 SRERVFSEDRA---RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC 296 RE E A + +I SA++YL +KN ++RDL N ++ ++ +K+ DFGL Sbjct: 114 -RECNRQEVNAVVLLYMATQISSAMEYLE-KKNFIHRDLAARNCLVGENHLVKVADFGLS 171 Query: 297 KEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDH 354 + D T P ++ APE L N + D W GV+++E+ G P+ D Sbjct: 172 RLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDL 231 Query: 355 EKLFELILMEEIRFPRTLG-PE-AKSLLSGLLKKDPKQR 391 +++EL L ++ R R G PE L+ + +P R Sbjct: 232 SQVYEL-LEKDYRMERPEGCPEKVYELMRACWQWNPSDR 269 >5Y86-A nrPDB Length = 588 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 106/215 (49%), Gaps = 21/215 (9%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 +E LK++GKG+FG+V V + +Y A+K+++ E K E R+L++ + Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE----KRFHRQAAEEIRILEHLKKQD 264 Query: 210 LTA------LKYSFQTHDRLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEIVSAL 261 T + SF + +C E + +L+ + + + FS R + I+ +L Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGH--IKITDFG-LCKEGIKDGATMKTFCGTPEYLAP 318 D LH K +++ DLK EN++L G K+ DFG C E K + T+ + Y AP Sbjct: 324 DALHKNK-IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK----LYTYIQSRFYRAP 378 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353 E++ + Y +D W G ++ E++ G+ F +D Sbjct: 379 EIILGSRYSTPIDIWSFGCILAELLTGQPLFPGED 413 >3BGP-A nrPDB Length = 333 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/257 (26%), Positives = 123/257 (47%), Gaps = 27/257 (10%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH---TLTENRVLQN 204 ++++ LLG G FG V + A+K ++K+ I E+ + E +L+ Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 205 SRHPFLTALKYS--FQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSAL 261 F ++ F+ D ++E + F ER E+ AR + +++ A+ Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 175 Query: 262 DYLHSEKNVVYRDLKLENLMLDKD-GHIKITDFGLCKEGIKDGATMKT-----FCGTPEY 315 + H+ V++RD+K EN+++D + G +K+ DFG GA +K F GT Y Sbjct: 176 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFG-------SGALLKDTVYTDFDGTRVY 227 Query: 316 LAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGP 374 PE + + Y GR+ W LG+++Y+M+CG +PF +H+ E I+ ++ F + + Sbjct: 228 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---EHD---EEIIRGQVFFRQRVSS 281 Query: 375 EAKSLLSGLLKKDPKQR 391 E + L+ L P R Sbjct: 282 ECQHLIRWCLALRPSDR 298 >6GVJ-A nrPDB Length = 429 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 69/293 (23%), Positives = 129/293 (44%), Gaps = 47/293 (16%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM----------KILK----KEVIV 187 +H++ + L++L + + I VK GR Y++ K+ + K+ I Sbjct: 116 QHQILATPLQNLQVLASSSANECISVK----GRIYSILKQIGSGGSSKVFQVLNEKKQIY 171 Query: 188 AKDEVAHTLTENRVLQNSRH--PFLTALK---------YSFQTHDRLCFVMEYANGGELF 236 A V +N+ L + R+ +L L+ Y ++ D+ +++ +L Sbjct: 172 AIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLN 231 Query: 237 FHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC 296 L +++ + Y ++ A+ +H + +V+ DLK N ++ DG +K+ DFG+ Sbjct: 232 SWLKKKKSIDPWERKSYWKNMLEAVHTIH-QHGIVHSDLKPANFLI-VDGMLKLIDFGIA 289 Query: 297 KEGIKDGATM--KTFCGTPEYLAPEVLEDNDYGR-----------AVDWWGLGVVMYEMM 343 + D ++ + GT Y+ PE ++D R D W LG ++Y M Sbjct: 290 NQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMT 349 Query: 344 CGRLPFYNQDHE--KLFELI-LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 G+ PF ++ KL +I EI FP + + +L LK+DPKQR+ Sbjct: 350 YGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRIS 402 >4XI2-A nrPDB Length = 446 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 100/205 (48%), Gaps = 11/205 (5%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 + +LK LG G FG V K + G+Y + +E +++DE + E +V+ N H Sbjct: 188 DLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSEDEF---IEEAKVMMNLSHE 242 Query: 209 FLTALKYSFQTHDRLCFVM-EYANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYLHS 266 L L Y T R F++ EY G L +L R F + ++ A++YL S Sbjct: 243 KLVQL-YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 301 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDND 325 K ++RDL N +++ G +K++DFGL + + D T P + PEVL + Sbjct: 302 -KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 360 Query: 326 YGRAVDWWGLGVVMYEMMC-GRLPF 349 + D W GV+M+E+ G++P+ Sbjct: 361 FSSKSDIWAFGVLMWEIYSLGKMPY 385 >1V0B-A nrPDB Length = 288 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 133/300 (44%), Gaps = 54/300 (18%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE--VAHTLTENRVLQN 204 M ++ L+ +G+GT+G V KA Y LKK + +DE + T+ E +L+ Sbjct: 1 MEKYHGLEKIGEGTYGVVY----KAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKE 56 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 +H + L T RL V E+ + E A+ + ++++ + Y Sbjct: 57 LKHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYC 116 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVL 321 H ++ V++RDLK +NL+++++G +KI DFGL + G ++ + T Y AP+VL Sbjct: 117 H-DRRVLHRDLKPQNLLINREGELKIADFGLARAF---GIPVRKYTHEVVTLWYRAPDVL 172 Query: 322 EDN-DYGRAVDWWGLGVVMYEMMCG--------------------------------RLP 348 + Y +D W +G + EM+ G LP Sbjct: 173 MGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELP 232 Query: 349 FYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 Y+ + ++E + E F + L LLS +LK DP QR+ AK+ ++H +F Sbjct: 233 KYDPNF-TVYEPLPWES--FLKGLDESGIDLLSKMLKLDPNQRI-----TAKQALEHAYF 284 >4NST-A nrPDB Length = 351 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 82/331 (24%), Positives = 144/331 (43%), Gaps = 66/331 (19%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT---ENRVL 202 +++F+ + ++G+GT+G+V K+K TG A+K +V + ++ +T E ++L Sbjct: 11 CVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALK----KVRLDNEKEGFPITAIREIKIL 66 Query: 203 QNSRHPFLTALK-YSFQTHDRLCF---------VMEYANGGELFFHLSRERVFSEDRARF 252 + H + +K D L F V EY + + S FSED + Sbjct: 67 RQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKS 126 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK-EGIKDGATMKTFCG 311 + +++ L+Y H +KN ++RD+K N++L+ G IK+ DFGL + ++ Sbjct: 127 FMKQLMEGLEYCH-KKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 312 TPEYLAPEVLEDND-YGRAVDWWGLGVVMYEM---------------------MCG---- 345 T Y PE+L + Y A+D W G ++ E+ +CG Sbjct: 186 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCP 245 Query: 346 -------RLPFYN-QDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSE 397 +LP++N +K + L EE F + A LL +L DP +R Sbjct: 246 AVWPDVIKLPYFNTMKPKKQYRRRLREEFSF---IPSAALDLLDHMLTLDPSKRCT---- 298 Query: 398 DAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428 A++ +Q F + V K++PP P Sbjct: 299 -AEQTLQSDFL-----KDVELSKMAPPDLPH 323 >4XEY-B nrPDB Length = 408 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 70/243 (28%), Positives = 112/243 (46%), Gaps = 14/243 (5%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG G +G+V K A+K LK++ + EV L E V++ +HP L L Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLG 188 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRA---RFYGAEIVSALDYLHSEKNVVY 272 + E+ G L +L RE E A + +I SA++YL +KN ++ Sbjct: 189 VCTREPPFYIITEFMTYGNLLDYL-RECNRQEVNAVVLLYMATQISSAMEYL-EKKNFIH 246 Query: 273 RDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVD 331 RDL N ++ ++ +K+ DFGL + D T P ++ APE L N + D Sbjct: 247 RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD 306 Query: 332 WWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLG-PE-AKSLLSGLLKKDP 388 W GV+++E+ G P+ D +++EL L ++ R R G PE L+ + +P Sbjct: 307 VWAFGVLLWEIATYGMSPYPGIDLSQVYEL-LEKDYRMERPEGCPEKVYELMRACWQWNP 365 Query: 389 KQR 391 R Sbjct: 366 SDR 368 >5X8I-B nrPDB Length = 346 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 71/266 (26%), Positives = 112/266 (42%), Gaps = 36/266 (13%) Query: 145 VTMNEFEYLKLLGKGTFGKVI-LVKEKATGRYYAMKILK---KEVIVAKDEVAHTLTENR 200 V +E + LG+G FGKV+ + KA GR+ A+KI+K + A+ E+ N Sbjct: 10 VLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNT 69 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFSEDRARFYGAEIVS 259 NS + L++ F+ H +C V E F + F D R +I Sbjct: 70 TDPNSTFRCVQMLEW-FEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGH-------------------IKITDFGLCKEGI 300 ++++LHS K + + DLK EN++ + + IK+ DFG Sbjct: 129 SVNFLHSNK-LTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG---SAT 184 Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360 D T T Y APEV+ + + D W +G ++ E G F D ++ L Sbjct: 185 YDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKE--HL 242 Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKK 386 +ME R LGP K ++ K+ Sbjct: 243 AMME-----RILGPLPKHMIQKTRKR 263 >6E4F-A nrPDB Length = 290 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 100/205 (48%), Gaps = 11/205 (5%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 + +LK LG G FG V K + G+Y + KE +++DE + E +V+ N H Sbjct: 32 DLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDEF---IEEAKVMMNLSHE 86 Query: 209 FLTALKYSFQTHDRLCFVM-EYANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYLHS 266 L L Y T R F++ EY G L +L R F + ++ A++YL S Sbjct: 87 KLVQL-YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLES 145 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDND 325 K ++RDL N +++ G +K++DFGL + + D T P + PEVL + Sbjct: 146 -KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 204 Query: 326 YGRAVDWWGLGVVMYEMMC-GRLPF 349 + D W GV+M+E+ G++P+ Sbjct: 205 FSSKSDIWAFGVLMWEIYSLGKMPY 229 >3QGY-A nrPDB Length = 286 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 64/252 (25%), Positives = 117/252 (46%), Gaps = 18/252 (7%) Query: 148 NEFEYLKLLGKGTFGKV----ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +E +++ +G G FG V L K+K A+K +K+ + D + E V+ Sbjct: 27 SELTFVQEIGSGQFGLVHLGYWLNKDKV-----AIKTIKEGSMSEDD----FIEEAEVMM 77 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALD 262 HP L L +C V E+ G L +L +R +F+ + ++ + Sbjct: 78 KLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMA 137 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVL 321 YL E V++RDL N ++ ++ IK++DFG+ + + D T T P ++ +PEV Sbjct: 138 YLE-EACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVF 196 Query: 322 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSL 379 + Y D W GV+M+E+ G++P+ N+ + ++ E I + PR + Sbjct: 197 SFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQI 256 Query: 380 LSGLLKKDPKQR 391 ++ K+ P+ R Sbjct: 257 MNHCWKERPEDR 268 >3NIZ-A nrPDB Length = 311 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 72/300 (24%), Positives = 134/300 (44%), Gaps = 53/300 (17%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE--VAHTLTENRVLQN 204 M +++ L+ +G+GT+G V K+ + GR A+K ++ + A+DE + + E +L+ Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLD---AEDEGIPSTAIREISLLKE 75 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 HP + +L + L V E+ + + + + Y +++ + + Sbjct: 76 LHHPNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHC 135 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVL 321 H + +++RDLK +NL+++ DG +K+ DFGL + G ++++ T Y AP+VL Sbjct: 136 HQHR-ILHRDLKPQNLLINSDGALKLADFGLARAF---GIPVRSYTHEVVTLWYRAPDVL 191 Query: 322 EDN-DYGRAVDWWGLGVVMYEMMCGR--------------------------------LP 348 + Y +VD W +G + EM+ G+ LP Sbjct: 192 MGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELP 251 Query: 349 FYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + Q ++FE I P E LLS +L DP +R+ A++ M H +F Sbjct: 252 LWKQRTFQVFEKKPWSSI-IP-GFCQEGIDLLSNMLCFDPNKRIS-----ARDAMNHPYF 304 >3GC9-A nrPDB Length = 370 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 52/211 (24%), Positives = 106/211 (50%), Gaps = 18/211 (8%) Query: 153 LKLLGKGTFGKVILVKEKATGRYYAMKILKK---EVIVAKDEVAHTLTENRVLQNSRHPF 209 L+ +G G +G V + + A+K L + +I A+ T E R+L++ +H Sbjct: 33 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHAR----RTYRELRLLKHLKHEN 88 Query: 210 LTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 + L F + +++ G +L ++ + + S++ +F +++ L Y+ Sbjct: 89 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLN-NIVKSQALSDEHVQFLVYQLLRGLKYI 147 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED- 323 HS +++RDLK N+ +++D ++I DFGL ++ ++ M + T Y APE++ + Sbjct: 148 HS-AGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE---MTGYVATRWYRAPEIMLNW 203 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354 Y + VD W +G +M E++ G+ F D+ Sbjct: 204 MHYNQTVDIWSVGCIMAELLQGKALFPGSDY 234 >5AIR-A nrPDB Length = 430 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 79/301 (26%), Positives = 129/301 (42%), Gaps = 66/301 (21%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR---HPFL 210 K++G G+FG V K +G E++ K + +NR LQ R H + Sbjct: 70 KVIGNGSFGVVYQAKLCDSG----------ELVAIKKVLQDKRFKNRELQIMRKLDHCNI 119 Query: 211 TALKYSFQTHDR------LCFVMEYANGGELFFHLSR-----ERVFSEDRARFYGAEIVS 259 L+Y F + L V++Y E + ++R ++ + Y ++ Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 177 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHI-KITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 +L Y+HS + +RD+K +NL+LD D + K+ DFG K+ ++ + C Y AP Sbjct: 178 SLAYIHSF-GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR-YYRAP 235 Query: 319 E-VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH--EKLFELILM------EEIR-- 367 E + DY ++D W G V+ E++ G+ P + D ++L E+I + E+IR Sbjct: 236 ELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREM 294 Query: 368 --------FPRTLG------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407 FP+ PEA +L S LL+ P RL E H F Sbjct: 295 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSF 349 Query: 408 F 408 F Sbjct: 350 F 350 >5H2U-A nrPDB Length = 267 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 62/250 (24%), Positives = 113/250 (45%), Gaps = 15/250 (6%) Query: 149 EFEYLKLLGKGTFGKVI--LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 EF + LG G FG+V L K++ A+K++ ++ ++ + + +E + ++ R Sbjct: 7 EFTLCRKLGSGYFGEVFEGLWKDRVQ---VAIKVISRDNLLHQQMLQ---SEIQAMKKLR 60 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHL--SRERVFSEDRARFYGAEIVSALDYL 264 H + AL D + + E G L L S E+V ++ + YL Sbjct: 61 HKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLED 323 S+ N ++RDL N+++ ++ K+ DFGL + IK+ + P ++ APE L Sbjct: 121 ESQ-NYIHRDLAARNILVGENTLCKVGDFGLARL-IKEDVYLSHDHNIPYKWTAPEALSR 178 Query: 324 NDYGRAVDWWGLGVVMYEMMC-GRLPFYN-QDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 Y D W G++++EM G++P+ +HE + + P P L+ Sbjct: 179 GHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLML 238 Query: 382 GLLKKDPKQR 391 +DP+QR Sbjct: 239 TCWCRDPEQR 248 >2FO0-A nrPDB Length = 495 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 69/243 (28%), Positives = 112/243 (46%), Gaps = 14/243 (5%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG G +G+V K A+K LK++ + EV L E V++ +HP L L Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLG 280 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRA---RFYGAEIVSALDYLHSEKNVVY 272 + E+ G L +L RE E A + +I SA++YL +KN ++ Sbjct: 281 VCTREPPFYIITEFMTYGNLLDYL-RECNRQEVNAVVLLYMATQISSAMEYLE-KKNFIH 338 Query: 273 RDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVD 331 R+L N ++ ++ +K+ DFGL + D T P ++ APE L N + D Sbjct: 339 RNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD 398 Query: 332 WWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLG-PE-AKSLLSGLLKKDP 388 W GV+++E+ G P+ D +++EL L ++ R R G PE L+ + +P Sbjct: 399 VWAFGVLLWEIATYGMSPYPGIDLSQVYEL-LEKDYRMERPEGCPEKVYELMRACWQWNP 457 Query: 389 KQR 391 R Sbjct: 458 SDR 460 >2QKW-B nrPDB Length = 321 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 95/205 (46%), Gaps = 11/205 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 N F++ L+G G FGKV K R A LK+ + + TE L RH Sbjct: 39 NNFDHKFLIGHGVFGKVY----KGVLRDGAKVALKRRTPESSQGIEEFETEIETLSFCRH 94 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI----VSALDY 263 P L +L + + + +Y G L HL + + + EI L Y Sbjct: 95 PHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHY 154 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK-DGATMKTFC-GTPEYLAPEVL 321 LH+ + +++RD+K N++LD++ KITDFG+ K+G + D + T GT Y+ PE Sbjct: 155 LHT-RAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYF 213 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGR 346 D + GVV++E++C R Sbjct: 214 IKGRLTEKSDVYSFGVVLFEVLCAR 238 >3HMP-A nrPDB Length = 342 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 74/304 (24%), Positives = 132/304 (43%), Gaps = 35/304 (11%) Query: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171 K E + MD D+ A K R+ + LK +G G KV V + Sbjct: 24 KFERQHMDSPDLGTDDDDKASSSANECISVKGRI----YSILKQIGSGGSSKVFQVLNEK 79 Query: 172 TGRYYAMKILKKE------VIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF 225 + YA+K + E + ++E+A+ N++ Q+S Y ++ D+ + Sbjct: 80 K-QIYAIKYVNLEEADNQTLDSYRNEIAYL---NKLQQHSDKIIRL---YDYEITDQYIY 132 Query: 226 VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 285 ++ +L L +++ + Y ++ A+ +H + +V+ DLK N ++ D Sbjct: 133 MVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH-QHGIVHSDLKPANFLI-VD 190 Query: 286 GHIKITDFGLCKEGIKDGATM--KTFCGTPEYLAPEVLEDNDYGR-----------AVDW 332 G +K+ DFG+ + D ++ + GT Y+ PE ++D R D Sbjct: 191 GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDV 250 Query: 333 WGLGVVMYEMMCGRLPFYNQDHE--KLFELI-LMEEIRFPRTLGPEAKSLLSGLLKKDPK 389 W LG ++Y M G+ PF ++ KL +I EI FP + + +L LK+DPK Sbjct: 251 WSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPK 310 Query: 390 QRLG 393 QR+ Sbjct: 311 QRIS 314 >6DBN-A nrPDB Length = 316 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 70/224 (31%), Positives = 107/224 (47%), Gaps = 20/224 (8%) Query: 136 VSLAKPKHRVTMNEFE--YLKL---LGKGTFGKVILVK----EKATGRYYAMKILKKEVI 186 VS KP V FE +LK LG+G FGKV L + TG A+K LK E Sbjct: 18 VSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPES- 76 Query: 187 VAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR---LCFVMEYANGGELFFHLSRER 243 + +A E +L+N H + K T D + +ME+ G L +L + + Sbjct: 77 -GGNHIADLKKEIEILRNLYHENIVKYK-GICTEDGGNGIKLIMEFLPSGSLKEYLPKNK 134 Query: 244 VFSEDRARF-YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGI 300 + + Y +I +DYL S + V+RDL N++++ + +KI DFGL K E Sbjct: 135 NKINLKQQLKYAVQICKGMDYLGS-RQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETD 193 Query: 301 KDGATMKTFCGTPEY-LAPEVLEDNDYGRAVDWWGLGVVMYEMM 343 K+ T+K +P + APE L + + A D W GV ++E++ Sbjct: 194 KEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELL 237 >4EQM-A nrPDB Length = 294 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 99/212 (46%), Gaps = 12/212 (5%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE-NRVL 202 ++ ++ + LG G V L ++ +K+ K + + E TL R + Sbjct: 7 KIINERYKIVDKLGGGGMSTVYLAEDTILN----IKVAIKAIFIPPREKEETLKRFEREV 62 Query: 203 QNSR---HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 NS H + ++ + D VMEY G L ++ S D A + +I+ Sbjct: 63 HNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILD 122 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT--FCGTPEYLA 317 + + H + +V+RD+K +N+++D + +KI DFG+ K + + + +T GT +Y + Sbjct: 123 GIKHAHDMR-IVHRDIKPQNILIDSNKTLKIFDFGIAK-ALSETSLTQTNHVLGTVQYFS 180 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 PE + D + +G+V+YEM+ G PF Sbjct: 181 PEQAKGEATDECTDIYSIGIVLYEMLVGEPPF 212 >4AU8-A nrPDB Length = 296 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 70/297 (23%), Positives = 134/297 (45%), Gaps = 48/297 (16%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE--VAHTLTENRVLQNSR 206 ++E L+ +G+GT+G V K + T A+K ++ + DE + L E +L+ + Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD---DDDEGVPSSALREICLLKELK 63 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 H + L + +L V E+ + + S + + + +++ L + HS Sbjct: 64 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 123 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVLED 323 +NV++RDLK +NL+++++G +K+ DFGL + G ++ + T Y P+VL Sbjct: 124 -RNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 324 ND-YGRAVDWWGLGVVMYEMMCGRLPFY-----NQDHEKLFELI---------LMEEI-- 366 Y ++D W G + E+ P + + +++F L+ M ++ Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 239 Query: 367 -----RFPRT---------LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 +P T L + LL LLK +P QR+ A+E +QH +F+ Sbjct: 240 YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFS 291 >4JLC-A nrPDB Length = 657 Score = 71.2 bits (173), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 96/213 (45%), Gaps = 23/213 (10%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG YA+K+ + +V + E VL+ H + L Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL- 71 Query: 215 YSFQ---THDRLCFVMEYANGGELFFHL---SRERVFSEDRARFYGAEIVSALDYLHSEK 268 ++ + T +ME+ G L+ L S E ++V +++L E Sbjct: 72 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR-EN 130 Query: 269 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 +V+RD+K N+M + +DG K+TDFG +E ++D + GT EYL P++ E Sbjct: 131 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERA 189 Query: 323 ------DNDYGRAVDWWGLGVVMYEMMCGRLPF 349 YG VD W +GV Y G LPF Sbjct: 190 VLRKDHQKKYGATVDLWSVGVTFYHAATGSLPF 222 >4OLI-A nrPDB Length = 645 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/230 (29%), Positives = 102/230 (44%), Gaps = 26/230 (11%) Query: 131 AEEMEVSLAKPKHRVTMNEFEYLKL---LGKGTFGKVILV----KEKATGRYYAMKILKK 183 A+ + V+ P T+ YLK LG+G FGKV L TG A+K LK Sbjct: 333 ADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKA 392 Query: 184 EVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSF--QTHDRLCFVMEYANGGELFFHLSR 241 + + E +L+ H + K Q L VMEY G L +L R Sbjct: 393 DC--GPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPR 450 Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK---E 298 + + + +I + YLHS+ + ++R+L N++LD D +KI DFGL K E Sbjct: 451 HSI-GLAQLLLFAQQICEGMAYLHSQ-HYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPE 508 Query: 299 G-----IKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343 G +++ F + APE L++ + A D W GV +YE++ Sbjct: 509 GHEYYRVREDGDSPVF-----WYAPECLKEYKFYYASDVWSFGVTLYELL 553 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 76/283 (26%), Positives = 116/283 (40%), Gaps = 42/283 (14%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVI--LVKEKATGRYYAMKILKKEVIV-AKDEVAHTLTEN 199 HRV E L LG+GT V ++ + +G K+ ++ +V +D Sbjct: 40 HRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVL 99 Query: 200 RVLQNSRHP-----FLTALKYSFQTHDRLCF-------------VMEYANGGELFFHLSR 241 +VL S H + TA S +H L F V EY G L L R Sbjct: 100 KVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRR 159 Query: 242 ERVFSEDRARFYGA-EIVSALDYLHSEKNVVYRDLKLENLMLDKDG-------HIKITDF 293 ER + A ++ SAL YL + KN+V+ ++ N++L + G IK++D Sbjct: 160 ERGHVPMAWKMVVAQQLASALSYLEN-KNLVHGNVCGRNILLARLGLAEGTSPFIKLSDP 218 Query: 294 GLCKEGIKDGATMKTFCGTPEYLAPEVLED--NDYGRAVDWWGLGVVMYEMMC--GRLPF 349 G+ + ++ +LAPE L N A+D WG G + E +C G P Sbjct: 219 GVGLGALSREERVERI----PWLAPECLPGGANSLSTAMDKWGFGATLLE-ICFDGEAPL 273 Query: 350 YNQD-HEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 ++ EK E + R P P+ +L S L +P QR Sbjct: 274 QSRSPSEK--EHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR 314 >4E93-A nrPDB Length = 377 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/231 (26%), Positives = 107/231 (46%), Gaps = 13/231 (5%) Query: 139 AKPKHRVTMNEFEYL--KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 196 A PK + +N + + + +G+G FG+V + +A A+K ++ + D A L Sbjct: 103 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE--TLPPDLKAKFL 160 Query: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYG 254 E R+L+ HP + L + VME GG+ L E R+ + + G Sbjct: 161 QEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVG 220 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG--ATMKTFCGT 312 + + ++YL S K ++RDL N ++ + +KI+DFG+ +E DG A Sbjct: 221 -DAAAGMEYLES-KCCIHRDLAARNCLVTEKNVLKISDFGMSREE-ADGVYAASGGLRQV 277 Query: 313 P-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 P ++ APE L Y D W G++++E G P+ N +++ E + Sbjct: 278 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV 328 >5Z33-A nrPDB Length = 425 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 72/279 (25%), Positives = 117/279 (41%), Gaps = 42/279 (15%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTA 212 K LG+G +G V T A+K + V K L E ++LQ+ R H +T Sbjct: 37 KELGQGAYGIVCAAVNNQTSEGVAIKKVTN-VFSKKILAKRALREIKLLQHFRGHRNITC 95 Query: 213 L-KYSFQTHDRL--CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 L D ++ E +L + + ++ + + +I+ L Y+HS N Sbjct: 96 LYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHS-AN 154 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCK----EGIKDGATMKTFCGTPEYLAPEV-LEDN 324 V++RDLK NL+++ D +KI DFGL + + ++ M + T Y APE+ L Sbjct: 155 VLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIMLSFQ 214 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL----------MEEIRFPR---- 370 Y +A+D W +G ++ E++ GR F +D+ IL + I PR Sbjct: 215 SYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEY 274 Query: 371 -----------------TLGPEAKSLLSGLLKKDPKQRL 392 P+A LL +L DP R+ Sbjct: 275 VRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRI 313 >4NEU-A nrPDB Length = 333 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 86/211 (40%), Gaps = 18/211 (8%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 L G FGKV L + G + K + +E L E +++ RH + L Sbjct: 32 LDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEA--LLEEAKMMNRLRHSRVVKLLG 89 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 + VMEY G L L E EI+ + YLH K V+++DL Sbjct: 90 VIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHG-KGVIHKDL 148 Query: 276 KLENLMLDKDGHIKITDFGLC-------------KEGIKDGATMKTFCGTPEYLAPEVLE 322 K EN+++D D HIKI D GL E + T K GT Y+APE L Sbjct: 149 KPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLN 208 Query: 323 DNDY--GRAVDWWGLGVVMYEMMCGRLPFYN 351 D + D + VV++ + + P+ N Sbjct: 209 DVNAKPTEKSDVYSFAVVLWAIFANKEPYEN 239 >5AP3-A nrPDB Length = 313 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 66/266 (24%), Positives = 121/266 (45%), Gaps = 31/266 (11%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE------VIVAKDEVAHTLTENRVLQ 203 + LK +G G KV V + + YA+K + E + ++E+A+ N++ Q Sbjct: 30 YSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYL---NKLQQ 85 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 +S Y ++ D+ +++ +L L +++ + Y ++ A+ Sbjct: 86 HSDKIIRL---YDYEITDQYIYMVMECGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHT 142 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM--KTFCGTPEYLAPEVL 321 +H + +V+ DLK N ++ DG +K+ DFG+ + D ++ + GT Y+ PE + Sbjct: 143 IH-QHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 200 Query: 322 EDNDYGR-----------AVDWWGLGVVMYEMMCGRLPFYNQDHE--KLFELI-LMEEIR 367 +D R D W LG ++Y M G+ PF ++ KL +I EI Sbjct: 201 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIE 260 Query: 368 FPRTLGPEAKSLLSGLLKKDPKQRLG 393 FP + + +L LK+DPKQR+ Sbjct: 261 FPDIPEKDLQDVLKCCLKRDPKQRIS 286 >4EUT-A nrPDB Length = 396 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 96/213 (45%), Gaps = 23/213 (10%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL- 72 Query: 215 YSFQ---THDRLCFVMEYANGGELFFHL---SRERVFSEDRARFYGAEIVSALDYLHSEK 268 ++ + T +ME+ G L+ L S E ++V +++L E Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR-EN 131 Query: 269 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 +V+R++K N+M + +DG K+TDFG +E ++D + GT EYL P++ E Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERA 190 Query: 323 ------DNDYGRAVDWWGLGVVMYEMMCGRLPF 349 YG VD W +GV Y G LPF Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >5EFQ-A nrPDB Length = 347 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 116/236 (49%), Gaps = 22/236 (9%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT---ENRVL 202 +++F+ + ++G+GT+G+V ++K TG A+K +V + ++ +T E ++L Sbjct: 9 CVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALK----KVRLDNEKEGFPITAIREIKIL 64 Query: 203 QNSRHPFLTALK-YSFQTHDRLCF---------VMEYANGGELFFHLSRERVFSEDRARF 252 + H + +K D L F V EY + + S F+E+ + Sbjct: 65 RQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKS 124 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK-EGIKDGATMKTFCG 311 + +++ LDY H +KN ++RD+K N++L+ G IK+ DFGL + ++ Sbjct: 125 FMRQLMEGLDYCH-KKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVI 183 Query: 312 TPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366 T Y PE+L + Y A+D W G ++ E+ + F Q +++L +L L+ I Sbjct: 184 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIF--QANQELAQLELISRI 237 >6DBM-A nrPDB Length = 318 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 93/204 (45%), Gaps = 27/204 (13%) Query: 156 LGKGTFGKVILV----KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLT 211 LG+G FGKV L TG A+K LK + + E +L+ H + Sbjct: 39 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADA--GPQHRSGWKQEIDILRTLYHEHI- 95 Query: 212 ALKYSFQTHD----RLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 +KY D L VMEY G L +L R + + + +I + YLHS+ Sbjct: 96 -IKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSI-GLAQLLLFAQQICEGMAYLHSQ 153 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCK---EG-----IKDGATMKTFCGTPEYLAPE 319 + ++RDL N++LD D +KI DFGL K EG +++ F + APE Sbjct: 154 -HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF-----WYAPE 207 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMM 343 L++ + A D W GV +YE++ Sbjct: 208 CLKEYKFYYASDVWSFGVTLYELL 231 >4F0G-A nrPDB Length = 287 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 70/279 (25%), Positives = 125/279 (44%), Gaps = 41/279 (14%) Query: 141 PKHRVTM---NEFEYLKLLGKGTFGKV---ILVKEKATGRYYAMKILKKEVIVAKDEVAH 194 PK R+ NE EY K +GKG FG V LVK+K+ + K +I+ E Sbjct: 9 PKSRLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSV-------VAIKSLILGDSEGET 61 Query: 195 TLTEN--------RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL--SRERV 244 + E ++ N HP + L R+ VME+ G+L+ L + Sbjct: 62 EMIEKFQEFQREVFIMSNLNHPNIVKLYGLMHNPPRM--VMEFVPCGDLYHRLLDKAHPI 119 Query: 245 FSEDRARFYGAEIVSALDYLHSEK-NVVYRDLKLENLM---LDKDGHI--KITDFGLCKE 298 + R +I ++Y+ ++ +V+RDL+ N+ LD++ + K+ DFGL ++ Sbjct: 120 KWSVKLRLM-LDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ 178 Query: 299 GIKDGATMKTFCGTPEYLAPEVL--EDNDYGRAVDWWGLGVVMYEMMCGRLPF--YNQDH 354 + ++ G +++APE + E+ Y D + +++Y ++ G PF Y+ Sbjct: 179 SVH---SVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGK 235 Query: 355 EKLFELILMEEIR--FPRTLGPEAKSLLSGLLKKDPKQR 391 K +I E +R P P ++++ DPK+R Sbjct: 236 IKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKR 274 >4EUU-A nrPDB Length = 319 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 96/213 (45%), Gaps = 23/213 (10%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLNHKNIVKL- 72 Query: 215 YSFQ---THDRLCFVMEYANGGELFFHL---SRERVFSEDRARFYGAEIVSALDYLHSEK 268 ++ + T +ME+ G L+ L S E ++V +++L E Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR-EN 131 Query: 269 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 +V+R++K N+M + +DG K+TDFG +E ++D + GT EYL P++ E Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERA 190 Query: 323 ------DNDYGRAVDWWGLGVVMYEMMCGRLPF 349 YG VD W +GV Y G LPF Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >5WNO-A nrPDB Length = 330 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 95/208 (45%), Gaps = 20/208 (9%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA-------KDEVAHTLTENRVLQNSR 206 K LG G FG V G YY + ++ VA + + L E + R Sbjct: 28 KKLGAGAFGTVF------AGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLR 81 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDYL 264 H L + D L V Y G L F L +E + + ++ Y +I S + YL Sbjct: 82 HDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQV-LYCYQIASGMQYL 140 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPEVLE 322 ++ VV+RDL N+++ K H++ITDFGL K + D T+K+ ++LA E+ Sbjct: 141 EKQR-VVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFS 199 Query: 323 DNDYGRAVDWWGLGVVMYEMMC-GRLPF 349 + Y A D W GV +E++ G+ P+ Sbjct: 200 KHCYTHASDVWAFGVTCWEIITFGQSPY 227 >3OZ6-A nrPDB Length = 388 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 119/275 (43%), Gaps = 38/275 (13%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R + ++E +K LGKG +G V ++ TG A+K + + D T E +L Sbjct: 5 RHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTD-AQRTFREIMILT 63 Query: 204 N-SRHPFLTALKYSFQT-HDR-LCFVMEYANGGELFFH-LSRERVFSEDRARFYGAEIVS 259 S H + L + +DR + V +Y E H + R + ++ +++ Sbjct: 64 ELSGHENIVNLLNVLRADNDRDVYLVFDYM---ETDLHAVIRANILEPVHKQYVVYQLIK 120 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK------------------ 301 + YLHS +++RD+K N++L+ + H+K+ DFGL + + Sbjct: 121 VIKYLHS-GGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTEN 179 Query: 302 ---DGATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357 D + + T Y APE+ L Y + +D W LG ++ E++CG+ F Sbjct: 180 FDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQ 239 Query: 358 FELILMEEIRFPRT------LGPEAKSLLSGLLKK 386 E I+ I FP P AK+++ L +K Sbjct: 240 LERII-GVIDFPSNEDVESIQSPFAKTMIESLKEK 273 >2ZMD-A nrPDB Length = 390 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 73/303 (24%), Positives = 131/303 (43%), Gaps = 35/303 (11%) Query: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171 K E + MD D+ A K R+ + LK +G G KV V + Sbjct: 24 KFERQHMDSPDLGTDDDDKASSSANECISVKGRI----YSILKQIGSGGSSKVFQVLNEK 79 Query: 172 TGRYYAMKILKKE------VIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF 225 + YA+K + E + ++E+A+ N++ Q+S Y ++ D+ + Sbjct: 80 K-QIYAIKYVNLEEADNQTLDSYRNEIAYL---NKLQQHSDKIIRL---YDYEITDQYIY 132 Query: 226 VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 285 ++ +L L +++ + Y ++ A+ +H + +V+ DLK N ++ D Sbjct: 133 MVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH-QHGIVHSDLKPANFLI-VD 190 Query: 286 GHIKITDFGLCKEGIKDGATM--KTFCGTPEYLAPEVLEDNDYGR-----------AVDW 332 G +K+ DFG+ + D ++ + G Y+ PE ++D R D Sbjct: 191 GMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDV 250 Query: 333 WGLGVVMYEMMCGRLPFYNQDHE--KLFELI-LMEEIRFPRTLGPEAKSLLSGLLKKDPK 389 W LG ++Y M G+ PF ++ KL +I EI FP + + +L LK+DPK Sbjct: 251 WSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPK 310 Query: 390 QRL 392 QR+ Sbjct: 311 QRI 313 >1FVR-A nrPDB Length = 327 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 60/231 (25%), Positives = 105/231 (45%), Gaps = 22/231 (9%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSR 206 N+ ++ ++G+G FG+V+ + K G I + + +KD+ E VL + Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRA---------------- 250 HP + L + + L +EYA G L L + RV D A Sbjct: 85 HPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC 310 + A++ +DYL S+K ++RDL N+++ ++ KI DFGL + ++ KT Sbjct: 145 LHFAADVARGMDYL-SQKQFIHRDLAARNILVGENYVAKIADFGLSRG--QEVYVKKTMG 201 Query: 311 GTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFE 359 P ++A E L + Y D W GV+++E++ G P+ +L+E Sbjct: 202 RLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYE 252 >3MIA-A nrPDB Length = 351 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 78/311 (25%), Positives = 145/311 (46%), Gaps = 60/311 (19%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT---ENRVLQ 203 ++++E L +G+GTFG+V + + TG+ A+K +V++ ++ +T E ++LQ Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK----KVLMENEKEGFPITALREIKILQ 71 Query: 204 NSRHPFLTALKYSFQT----HDR----LCFVMEYANGGELFFHLSRERV-FSEDRARFYG 254 +H + L +T ++R + V ++ +L LS V F+ + Sbjct: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVM 130 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE-GIKDGATMKTFCG-- 311 +++ L Y+H K +++RD+K N+++ +DG +K+ DFGL + + + + Sbjct: 131 QMLLNGLYYIHRNK-ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 Query: 312 -TPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEM---------------------MCGRLP 348 T Y PE +L + DYG +D WG G +M EM +CG + Sbjct: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 Query: 349 ---FYNQDHEKLF---ELILMEEIRFPRTL-----GPEAKSLLSGLLKKDPKQRLGGGSE 397 + N D+ +L+ EL+ ++ + L P A L+ LL DP QR+ Sbjct: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI----- 304 Query: 398 DAKEIMQHRFF 408 D+ + + H FF Sbjct: 305 DSDDALNHDFF 315 >6NT9-A nrPDB Length = 742 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 96/213 (45%), Gaps = 23/213 (10%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL- 70 Query: 215 YSFQ---THDRLCFVMEYANGGELFFHL---SRERVFSEDRARFYGAEIVSALDYLHSEK 268 ++ + T +ME+ G L+ L S E ++V +++L E Sbjct: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR-EN 129 Query: 269 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 +V+R++K N+M + +DG K+TDFG +E ++D + GT EYL P++ E Sbjct: 130 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDMYERA 188 Query: 323 ------DNDYGRAVDWWGLGVVMYEMMCGRLPF 349 YG VD W +GV Y G LPF Sbjct: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 >4E7W-A nrPDB Length = 394 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 82/301 (27%), Positives = 131/301 (43%), Gaps = 67/301 (22%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR---HPFL 210 K++G G+FG V + K+++ + + K + +NR LQ R HP + Sbjct: 46 KVIGNGSFGVV-----------FQAKLVESDEVAIKKVLQDKRFKNRELQIMRIVKHPNV 94 Query: 211 TALKYSFQTH-DR-----LCFVMEYANGGELFFHLSR-----ERVFSEDRARFYGAEIVS 259 LK F ++ D+ L V+EY E + SR ++ + Y +++ Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYV--PETVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDK-DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 +L Y+HS + +RD+K +NL+LD G +K+ DFG K I + C Y AP Sbjct: 153 SLAYIHS-IGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSR-YYRAP 210 Query: 319 E-VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH-EKLFELILM------EEIRF-- 368 E + +Y +D W G VM E+M G+ F + ++L E+I + E+I+ Sbjct: 211 ELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMN 270 Query: 369 ---------------------PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407 PRT P+A L+S LL+ P RL A E + H F Sbjct: 271 PNYMEHKFPQIRPHPFSKVFRPRT-PPDAIDLISRLLEYTPSARL-----TAIEALCHPF 324 Query: 408 F 408 F Sbjct: 325 F 325 >3IO7-A nrPDB Length = 313 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 107/220 (48%), Gaps = 25/220 (11%) Query: 141 PKHRVTMNEFE-----YLKLLGKGTFGKVILVK----EKATGRYYAMKILKKEVIVAKDE 191 P+ M +FE +L+ LGKG FG V + + + TG A+K L+ ++ Sbjct: 16 PRGSHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS---TEEH 72 Query: 192 VAHTLTENRVLQNSRHPFLTALKYSFQTHDR--LCFVMEYANGGEL--FFHLSRERVFSE 247 + E +L++ +H + K + R L +MEY G L + +ER+ Sbjct: 73 LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERI--- 129 Query: 248 DRARF--YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA- 304 D + Y ++I ++YL + K ++RDL N++++ + +KI DFGL K +D Sbjct: 130 DHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEY 188 Query: 305 -TMKTFCGTPEY-LAPEVLEDNDYGRAVDWWGLGVVMYEM 342 +K +P + APE L ++ + A D W GVV+YE+ Sbjct: 189 YKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL 228 >6FER-A nrPDB Length = 309 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/232 (27%), Positives = 101/232 (43%), Gaps = 29/232 (12%) Query: 156 LGKGTFGKVILVK----EKATGRYYAMKILKKE-VIVA---------KDEVAHTLTENRV 201 LG+G FG+V L + EK + +A+ + + V+VA K+ L E ++ Sbjct: 17 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKI 76 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE----------RVFSEDRAR 251 + + P + L T D LC + EY G+L LSR R S + Sbjct: 77 MSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLK 136 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK-DGATMKTFC 310 F +I S + YL S N V+RDL N ++ K+ IKI DFG+ + D ++ Sbjct: 137 FMATQIASGMKYL-SSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRA 195 Query: 311 GTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYE--MMCGRLPFYNQDHEKLFE 359 P +++ E + + A D W GV ++E C P+ E++ E Sbjct: 196 VLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE 247 >4QTB-A nrPDB Length = 380 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 100/215 (46%), Gaps = 17/215 (7%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 + L+ +G+G +G V + A+K K + TL E ++L RH Sbjct: 43 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIK--KISPFEHQTYCQRTLREIQILLRFRHEN 100 Query: 210 LTA----LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 + L+ S R ++++ +L+ L + + S D ++ +I+ L Y+H Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIH 159 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD-----GATMKTFCGTPEYLAPEV 320 S NV++RDLK NL+++ +KI DFGL + I D + + T Y APE+ Sbjct: 160 S-ANVLHRDLKPSNLLINTTCDLKICDFGLAR--IADPEHDHTGFLTEYVATRWYRAPEI 216 Query: 321 -LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354 L Y +++D W +G ++ EM+ R P + H Sbjct: 217 MLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKH 250 >2J0K-A nrPDB Length = 656 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 115/259 (44%), Gaps = 17/259 (6%) Query: 143 HRVTMNEFEYLKLLGKGTFGKV---ILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTE 198 + + E + +G+G FG V I + + A+K K D V L E Sbjct: 385 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKN---CTSDSVREKFLQE 441 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF--YGAE 256 ++ HP + L T + + +ME GEL L + R FS D A Y + Sbjct: 442 ALTMRQFDHPHIVKL-IGVITENPVWIIMELCTLGELRSFL-QVRKFSLDLASLILYAYQ 499 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT--PE 314 + +AL YL S K V+RD+ N+++ +K+ DFGL + ++D K G + Sbjct: 500 LSTALAYLES-KRFVHRDIAARNVLVSATDCVKLGDFGLSRY-MEDSTYYKASKGKLPIK 557 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYE-MMCGRLPFYN-QDHEKLFELILMEEIRFPRTL 372 ++APE + + A D W GV M+E +M G PF ++++ + + E + P Sbjct: 558 WMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNC 617 Query: 373 GPEAKSLLSGLLKKDPKQR 391 P SL++ DP +R Sbjct: 618 PPTLYSLMTKCWAYDPSRR 636 >6O8B-A nrPDB Length = 665 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 95/213 (44%), Gaps = 23/213 (10%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKL- 78 Query: 215 YSFQ---THDRLCFVMEYANGGELFFHL---SRERVFSEDRARFYGAEIVSALDYLHSEK 268 ++ + T +ME+ G L+ L S E ++V +++L E Sbjct: 79 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR-EN 137 Query: 269 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 +V+R++K N+M + +DG K+TDFG +E ++D GT EYL P++ E Sbjct: 138 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVELYGTEEYLHPDMYERA 196 Query: 323 ------DNDYGRAVDWWGLGVVMYEMMCGRLPF 349 YG VD W +GV Y G LPF Sbjct: 197 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 229 >4EBW-A nrPDB Length = 304 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 69/259 (26%), Positives = 116/259 (44%), Gaps = 17/259 (6%) Query: 143 HRVTMNEFEYLKLLGKGTFGKV---ILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTE 198 + + E + +G+G FG V I + + A+K K D V L E Sbjct: 33 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN---CTSDSVREKFLQE 89 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF--YGAE 256 ++ HP + L T + + +ME GEL L + R +S D A Y + Sbjct: 90 ALTMRQFDHPHIVKL-IGVITENPVWIIMELCTLGELRSFL-QVRKYSLDLASLILYAYQ 147 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT--PE 314 + +AL YL S K V+RD+ N+++ + +K+ DFGL + ++D K G + Sbjct: 148 LSTALAYLES-KRFVHRDIAARNVLVSSNDCVKLGDFGLSRY-MEDSTYYKASKGKLPIK 205 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYE-MMCGRLPFYN-QDHEKLFELILMEEIRFPRTL 372 ++APE + + A D W GV M+E +M G PF ++++ + + E + P Sbjct: 206 WMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNC 265 Query: 373 GPEAKSLLSGLLKKDPKQR 391 P SL++ DP +R Sbjct: 266 PPTLYSLMTKCWAYDPSRR 284 >1G3N-A nrPDB Length = 326 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 102/209 (48%), Gaps = 21/209 (10%) Query: 148 NEFEYLKLLGKGTFGKVILVKE-KATGRYYAMKILKKEV------IVAKDEVAHTLTENR 200 ++E + +G+G +GKV ++ K GR+ A+K ++ + + EVA R Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL----R 66 Query: 201 VLQNSRHPFLTAL--KYSFQTHDR---LCFVMEYANGGELFFHLSR--ERVFSEDRARFY 253 L+ HP + L + DR L V E+ + +L +L + E + + Sbjct: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDM 125 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP 313 +++ LD+LHS + VV+RDLK +N+++ G IK+ DFGL + A + + T Sbjct: 126 MFQLLRGLDFLHSHR-VVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTL 183 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 Y APEVL + Y VD W +G + EM Sbjct: 184 WYRAPEVLLQSSYATPVDLWSVGCIFAEM 212 >5NGU-A nrPDB Length = 381 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 39/123 (31%), Positives = 64/123 (52%), Gaps = 6/123 (4%) Query: 236 FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGL 295 + L + + S D ++ +I+ L Y+HS NV++RDLK NL+L+ +KI DFGL Sbjct: 131 LYKLLKTQHLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLLNTTCDLKICDFGL 189 Query: 296 CKEGIKD---GATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN 351 + D + + T Y APE+ L Y +++D W +G ++ EM+ R P + Sbjct: 190 ARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFP 248 Query: 352 QDH 354 H Sbjct: 249 GKH 251 >3BEA-A nrPDB Length = 333 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 103/218 (47%), Gaps = 27/218 (12%) Query: 148 NEFEYLKLLGKGTFGKVI------LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 N ++ K LG G FGKV+ L KE A + A+K+LK DE ++E ++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKV-AVKMLKSTA--HADEKEALMSELKI 102 Query: 202 LQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEIVS 259 + + +H + L + + + EY G+L L R+ RV D A +S Sbjct: 103 MSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLS 162 Query: 260 ALDYLH------------SEKNVVYRDLKLENLMLDKDGHI-KITDFGLCKEGIKDGA-T 305 D LH + KN ++RD+ N++L +GH+ KI DFGL ++ + D Sbjct: 163 TRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYI 221 Query: 306 MKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 +K P +++APE + D Y D W G++++E+ Sbjct: 222 VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEI 259 >2W1I-A nrPDB Length = 326 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 102/206 (49%), Gaps = 20/206 (9%) Query: 150 FEYLKLLGKGTFGKVILVK----EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 ++L+ LGKG FG V + + + TG A+K L+ ++ + E +L++ Sbjct: 43 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS---TEEHLRDFEREIEILKSL 99 Query: 206 RHPFLTALKYSFQTHDR--LCFVMEYANGGEL--FFHLSRERVFSEDRARF--YGAEIVS 259 +H + K + R L +MEY G L + +ER+ D + Y ++I Sbjct: 100 QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERI---DHIKLLQYTSQICK 156 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA--TMKTFCGTPEY-L 316 ++YL + K ++RDL N++++ + +KI DFGL K +D +K +P + Sbjct: 157 GMEYLGT-KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY 215 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEM 342 APE L ++ + A D W GVV+YE+ Sbjct: 216 APESLTESKFSVASDVWSFGVVLYEL 241 >4O2Z-A nrPDB Length = 377 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 96/203 (47%), Gaps = 11/203 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +++ LK+LG G +G + TG ++K + +V ++ L E +++ H Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCR-DVFRDVEDGKRVLREIDMMRFFHH 103 Query: 208 P-------FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 L LK + + + + +V+ ++ L +V E +++ +I+ Sbjct: 104 ENLLNVVNILPPLKREYHSFEDV-YVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQILRG 162 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE- 319 L YLHS NV +RDLK NL+ + +KI DFGL + + + + T Y PE Sbjct: 163 LKYLHS-ANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPEL 221 Query: 320 VLEDNDYGRAVDWWGLGVVMYEM 342 +LE+ +Y AVD W +G + EM Sbjct: 222 LLENTNYSTAVDIWSVGCIFAEM 244 >5AWM-A nrPDB Length = 394 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 92/214 (42%), Gaps = 56/214 (26%) Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 304 DR + +++ + +LHS +++RDLK N+++ D +KI DFGL + G Sbjct: 143 LDHDRMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKADCTLKILDFGLARTA---GT 198 Query: 305 T--MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLF 358 T M + T Y APEV+ Y VD W +G +M EM+ G + F DH K+ Sbjct: 199 TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 258 Query: 359 ELI------LMEEIR---------------------FPRTLGP------------EAKSL 379 E + M+ ++ FP L P +A++L Sbjct: 259 EQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNL 318 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413 LS +L DP+QR+ E ++H + VW Sbjct: 319 LSKMLVIDPEQRIS-----VDEALKHEYIN--VW 345 >3C1X-A nrPDB Length = 373 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 65/263 (24%), Positives = 117/263 (44%), Gaps = 18/263 (6%) Query: 102 AIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNE----FEYLKLLG 157 +I+ ++ L K+ E + G+ + + + L + V + + +++G Sbjct: 39 SIEELSTSLYKKAGSENLYFQGANTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIG 98 Query: 158 KGTFGKV---ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP-FLTAL 213 +G FG V L+ + A+K L + I EV+ LTE ++++ HP L+ L Sbjct: 99 RGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHPNVLSLL 156 Query: 214 KYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 ++ V+ Y G+L F +D F G ++ + +L S+K V Sbjct: 157 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGF-GLQVAKGMKFLASKK-FV 214 Query: 272 YRDLKLENLMLDKDGHIKITDFGLCKEGIK---DGATMKTFCGTP-EYLAPEVLEDNDYG 327 +RDL N MLD+ +K+ DFGL ++ D KT P +++A E L+ + Sbjct: 215 HRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFT 274 Query: 328 RAVDWWGLGVVMYEMMCGRLPFY 350 D W GV+++E+M P Y Sbjct: 275 TKSDVWSFGVLLWELMTRGAPPY 297 >3E7O-A nrPDB Length = 360 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 77/328 (23%), Positives = 125/328 (38%), Gaps = 63/328 (19%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + ++ LK +G G G V + G A+K L + + E +L+ Sbjct: 20 VLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP-FQNQTHAKRAYRELVLLKCV 78 Query: 206 RHPFLTALKYSFQTHDRL------CFVMEYANGGEL-FFHLSRERVFSEDRARFYGAEIV 258 H + +L F L VME + H+ +R + +++ Sbjct: 79 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME----LDHERMSYLLYQML 134 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 + +LHS +++RDLK N+++ D +KI DFGL + M + T Y AP Sbjct: 135 CGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-STNFMMTPYVVTRYYRAP 192 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH--------EKL------FELILME 364 EV+ Y VD W +G +M E++ G + F DH E+L F L Sbjct: 193 EVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQP 252 Query: 365 EIR-----------------FPRTLGP-----------EAKSLLSGLLKKDPKQRLGGGS 396 +R FP + P +A+ LLS +L DP +R+ Sbjct: 253 TVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS--- 309 Query: 397 EDAKEIMQHRFFAGIVWQHVYEKKLSPP 424 E ++H + VW E + PP Sbjct: 310 --VDEALRHPYIT--VWYDPAEAEAPPP 333 >6HMD-A nrPDB Length = 365 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 105/229 (45%), Gaps = 50/229 (21%) Query: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283 V EY N + F L + + ++ RFY E++ ALDY HS K +++RD+K N+M+D Sbjct: 126 ALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYELLKALDYCHS-KGIMHRDVKPHNVMID 181 Query: 284 -KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYE 341 + +++ D+GL E + + PE+L D Y ++D W LG ++ Sbjct: 182 HQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 240 Query: 342 MMCGRLPFYN-QDHE----KLFELILMEEI-------------RFPRTLG---------- 373 M+ R PF++ QD+ ++ +++ EE+ F LG Sbjct: 241 MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF 300 Query: 374 ----------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 PEA LL LL+ D +QRL AKE M+H +F +V Sbjct: 301 IHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEAMEHPYFYPVV 344 >4H1J-A nrPDB Length = 293 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 62/264 (23%), Positives = 118/264 (44%), Gaps = 13/264 (4%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKV---ILVKEKATGRYYAMKILKKEVIVAKDEV 192 V P++ + + ++LG+G FG+V + K A+K KK+ + E Sbjct: 12 VPRGSPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKE- 70 Query: 193 AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRAR 251 ++E +++N HP + L + +ME GEL +L R + Sbjct: 71 -KFMSEAVIMKNLDHPHIVKL-IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLV 128 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG 311 Y +I A+ YL S N V+RD+ + N+++ +K+ DFGL + + + Sbjct: 129 LYSLQICKAMAYLES-INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTR 187 Query: 312 TP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFP 369 P ++++PE + + A D W V M+E++ G+ PF+ +++ + +L + R P Sbjct: 188 LPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIG-VLEKGDRLP 246 Query: 370 R--TLGPEAKSLLSGLLKKDPKQR 391 + P +L++ DP R Sbjct: 247 KPDLCPPVLYTLMTRCWDYDPSDR 270 >4K33-A nrPDB Length = 325 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 65/262 (24%), Positives = 120/262 (45%), Gaps = 27/262 (10%) Query: 125 PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE 184 P + E+E+ A PK ++ K LG+G FG+V++ + + A K + Sbjct: 14 PPTLANVSELELP-ADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVA 72 Query: 185 VIVAKDE-----VAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238 V + KD+ ++ ++E +++ +H + L + L ++EYA G L Sbjct: 73 VKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREF 132 Query: 239 LSRERV----FSEDRAR------------FYGAEIVSALDYLHSEKNVVYRDLKLENLML 282 L R +S D ++ ++ ++YL S+K ++RDL N+++ Sbjct: 133 LRARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQK-CIHRDLAARNVLV 191 Query: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMY 340 +D +KI DFGL ++ +T G +++APE L D Y D W GV+++ Sbjct: 192 TEDNVMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLW 251 Query: 341 EMMC-GRLPFYNQDHEKLFELI 361 E+ G P+ E+LF+L+ Sbjct: 252 EIFTLGGSPYPGIPVEELFKLL 273 >5A46-A nrPDB Length = 386 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 66/266 (24%), Positives = 122/266 (45%), Gaps = 30/266 (11%) Query: 122 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL 181 SG+P +G E E+ P+ + + K LG+G FG+V+L + + ++ Sbjct: 16 SGTPM-LAGVSEYELP-EDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 73 Query: 182 KKEVIVAKDE-----VAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGEL 235 K V + K + ++ ++E +++ +H + L + L ++EYA+ G L Sbjct: 74 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 133 Query: 236 F-----------------FHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLE 278 H E++ S+D ++ ++YL S+K ++RDL Sbjct: 134 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC-AYQVARGMEYLASKK-CIHRDLAAR 191 Query: 279 NLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLG 336 N+++ +D +KI DFGL ++ KT G +++APE L D Y D W G Sbjct: 192 NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFG 251 Query: 337 VVMYEMMC-GRLPFYNQDHEKLFELI 361 V+++E+ G P+ E+LF+L+ Sbjct: 252 VLLWEIFTLGGSPYPGVPVEELFKLL 277 >2XS0-A nrPDB Length = 386 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 80/330 (24%), Positives = 125/330 (37%), Gaps = 61/330 (18%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + ++ LK +G G G V + R A+K L + + E +++ Sbjct: 24 VLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP-FQNQTHAKRAYRELVLMKCV 82 Query: 206 RHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 H + L F L VME + L + E +R + +++ Sbjct: 83 NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDAN-LCQVIQME--LDHERMSYLLYQMLC 139 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 + +LHS +++RDLK N+++ D +KI DFGL + M F T Y APE Sbjct: 140 GIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMVPFVVTRYYRAPE 197 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELI----------LMEE 365 V+ Y VD W +G +M EM+ G + F DH K+ E + L Sbjct: 198 VILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPT 257 Query: 366 IR-----------------FPRTLGP-----------EAKSLLSGLLKKDPKQRLGGGSE 397 +R FP L P +A+ LLS +L D +R+ Sbjct: 258 VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS---- 313 Query: 398 DAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427 E +QH + VW E + PP P Sbjct: 314 -VDEALQHPYIN--VWYDPSEAEAPPPKIP 340 >4M7I-A nrPDB Length = 299 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 69/287 (24%), Positives = 119/287 (41%), Gaps = 61/287 (21%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH--TLTENRVLQN 204 + +FE ++ LG+G FG V K K YA+K ++ + E+A + E + L Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIR----LPNRELAREKVMREVKALAK 59 Query: 205 SRHPFL------------------TALKYSFQTHDRLC---FVMEYANGGELFFHLSRER 243 HP + ++ K +LC + ++ NG R Sbjct: 60 LEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNG----------R 109 Query: 244 VFSEDRARFYGA----EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299 E+R R +I A+++LHS K +++RDLK N+ D +K+ DFGL Sbjct: 110 CTIEERERSVCLHIFLQIAEAVEFLHS-KGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAM 168 Query: 300 IKDGATMKTF------------CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347 +D GT Y++PE + N Y VD + LG++++E++ Sbjct: 169 DQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL---Y 225 Query: 348 PFYNQDHEKLFELILMEEIRFPRTLG---PEAKSLLSGLLKKDPKQR 391 PF Q E++ L + ++FP P ++ +L P +R Sbjct: 226 PFSTQ-MERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMER 271 >2PSQ-A nrPDB Length = 370 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 65/260 (25%), Positives = 120/260 (46%), Gaps = 31/260 (11%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR-------YYAMKIL 181 +G E E+ PK ++ K LG+G FG+V++ + + A+K+L Sbjct: 63 AGVSEYELP-EDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 121 Query: 182 KKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240 K + + +++ ++E +++ +H + L + L ++EYA+ G L +L Sbjct: 122 KDDA--TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLR 179 Query: 241 RERV----FSEDRARF------------YGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 R +S D R ++ ++YL S+K ++RDL N+++ + Sbjct: 180 ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK-CIHRDLAARNVLVTE 238 Query: 285 DGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 + +KI DFGL ++ KT G +++APE L D Y D W GV+M+E+ Sbjct: 239 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 298 Query: 343 MC-GRLPFYNQDHEKLFELI 361 G P+ E+LF+L+ Sbjct: 299 FTLGGSPYPGIPVEELFKLL 318 >3SXS-A nrPDB Length = 268 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 92/204 (45%), Gaps = 9/204 (4%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 E LK LG G FG V L K K G+Y + KE +++DE E + + HP Sbjct: 9 EITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSEDEF---FQEAQTMMKLSHP 63 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHL-SRERVFSEDRARFYGAEIVSALDYLHSE 267 L + V EY + G L +L S + + ++ + +L S Sbjct: 64 KLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESH 123 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDY 326 + ++RDL N ++D+D +K++DFG+ + + D P ++ APEV Y Sbjct: 124 Q-FIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKY 182 Query: 327 GRAVDWWGLGVVMYEMMC-GRLPF 349 D W G++M+E+ G++P+ Sbjct: 183 SSKSDVWAFGILMWEVFSLGKMPY 206 >5HLW-A nrPDB Length = 299 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 98/208 (47%), Gaps = 16/208 (7%) Query: 154 KLLGKGTFGKV---ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP-F 209 +++G+G FG V L+ + A+K L + I EV+ LTE ++++ HP Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHPNV 83 Query: 210 LTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 L+ L ++ V+ Y G+L F +D F G ++ + YL S+ Sbjct: 84 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGF-GLQVAKGMKYLASK 142 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD----GATMKTFCGTP-EYLAPEVLE 322 K V+RDL N MLD+ +K+ DFGL ++ + D KT P +++A E L+ Sbjct: 143 K-FVHRDLAARNCMLDEKFTVKVADFGLARD-MHDKEYYSVHNKTGAKLPVKWMALESLQ 200 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFY 350 + D W GV+++E+M P Y Sbjct: 201 TQKFTTKSDVWSFGVLLWELMTRGAPPY 228 >3RAW-A nrPDB Length = 381 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 72/270 (26%), Positives = 114/270 (42%), Gaps = 48/270 (17%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGR-YYAMKILKKEVIVAKDEVAHTLTENRVLQ----N 204 +E + LG+GTFGKV+ + A G+ A+KI++ V K A L N + + + Sbjct: 53 YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRN---VGKYREAARLEINVLKKIKEKD 109 Query: 205 SRHPFLTALKYS-FQTHDRLCFVMEYANGGELFFHLSRERVFSE---DRARFYGAEIVSA 260 + FL L F H +C E G+ F +E F R ++ A Sbjct: 110 KENKFLCVLMSDWFNFHGHMCIAFELL--GKNTFEFLKENNFQPYPLPHVRHMAYQLCHA 167 Query: 261 LDYLHSEKNVVYRDLKLENLMLD-------------------KDGHIKITDFGLCKEGIK 301 L +LH E + + DLK EN++ K+ I++ DFG Sbjct: 168 LRFLH-ENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFG---SATF 223 Query: 302 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 361 D T T Y PEV+ + + + D W +G +++E G F Q HE L+ Sbjct: 224 DHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLF--QTHENREHLV 281 Query: 362 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 +ME+I LGP + S ++ + KQ+ Sbjct: 282 MMEKI-----LGP----IPSHMIHRTRKQK 302 >3GC0-A nrPDB Length = 329 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 76/325 (23%), Positives = 143/325 (44%), Gaps = 56/325 (17%) Query: 126 SDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 185 + G M VS A +++ + + LG+GT+G+V + T A+K ++ E Sbjct: 14 AQTQGPGSMSVSAAPSA--TSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLE- 70 Query: 186 IVAKDEVAHT-LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV 244 ++ V T + E +L+ +H + LK + RL + EYA +L ++ + Sbjct: 71 -HEEEGVPGTAIREVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAE-NDLKKYMDKNPD 128 Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-----IKITDFGLCKEG 299 S + + ++++ +++ HS + ++RDLK +NL+L +KI DFGL + Sbjct: 129 VSMRVIKSFLYQLINGVNFCHSRR-CLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAF 187 Query: 300 IKDGATMKTFCG---TPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 G ++ F T Y PE+ L Y +VD W + + EM+ + P + D E Sbjct: 188 ---GIPIRQFTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLM-KTPLFPGDSE 243 Query: 356 -----KLFELILMEE--------------IRFPRTLGPEAKSLL------------SGLL 384 K+FE++ + + FP+ G K +L + +L Sbjct: 244 IDQLFKIFEVLGLPDDTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAML 303 Query: 385 KKDPKQRLGGGSEDAKEIMQHRFFA 409 + DP +R+ AK ++H +F+ Sbjct: 304 EMDPVKRIS-----AKNALEHPYFS 323 >6FYV-A nrPDB Length = 337 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 67/261 (25%), Positives = 106/261 (40%), Gaps = 36/261 (13%) Query: 150 FEYLKLLGKGTFGKVI-LVKEKATGRYYAMKILK---KEVIVAKDEVAHTLTENRVLQNS 205 +E + LG+G FGKV+ + G + A+KI+K + A+ E+ N NS Sbjct: 16 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 75 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFSEDRARFYGAEIVSALDYL 264 + L++ F H +C V E F + F D R +I ++++L Sbjct: 76 VFRCVQMLEW-FDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFL 134 Query: 265 HSEKNVVYRDLKLENLMLDKDGH-------------------IKITDFGLCKEGIKDGAT 305 H K + + DLK EN++ K + IK+ DFG D Sbjct: 135 HHNK-LTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFG---SATYDDEH 190 Query: 306 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE 365 T T Y APEV+ + + D W +G ++ E G F Q H+ L +ME Sbjct: 191 HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVF--QTHDSKEHLAMME- 247 Query: 366 IRFPRTLGPEAKSLLSGLLKK 386 R LGP + ++ K+ Sbjct: 248 ----RILGPIPQHMIQKTRKR 264 >3TT0-A nrPDB Length = 382 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 115/247 (46%), Gaps = 33/247 (13%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE-----VAHT 195 P+ R+ + K LG+G FG+V+L + + ++ K V + K + ++ Sbjct: 67 PRDRLVLG-----KPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 121 Query: 196 LTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-------------- 240 ++E +++ +H + L + L ++EYA+ G L +L Sbjct: 122 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPS 181 Query: 241 ---RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297 E++ S+D ++ ++YL S+K ++RDL N+++ +D +KI DFGL + Sbjct: 182 HNPEEQLSSKDLVSC-AYQVARGMEYLASKK-CIHRDLAARNVLVTEDNVMKIADFGLAR 239 Query: 298 EGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDH 354 + KT G +++APE L D Y D W GV+++E+ G P+ Sbjct: 240 DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV 299 Query: 355 EKLFELI 361 E+LF+L+ Sbjct: 300 EELFKLL 306 >3CJF-A nrPDB Length = 309 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 69/275 (25%), Positives = 120/275 (43%), Gaps = 32/275 (11%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVI-----LVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 P+ R+ + K LG+G FG+VI + + AT R A+K+LK+ E Sbjct: 25 PRDRLNLG-----KPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGA--THSEHRAL 77 Query: 196 LTENRVLQNSRHPF--LTALKYSFQTHDRLCFVMEYANGGELFFHLSRER---------- 243 ++E ++L + H + L + L ++E+ G L +L +R Sbjct: 78 MSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLY 137 Query: 244 --VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 + + Y ++ +++L S K ++RDL N++L + +KI DFGL ++ K Sbjct: 138 KDFLTLEHLICYSFQVAKGMEFLASRK-CIHRDLAARNILLSEKNVVKICDFGLARDIYK 196 Query: 302 D-GATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLF 358 D K P +++APE + D Y D W GV+++E+ G P+ ++ F Sbjct: 197 DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 256 Query: 359 ELILME--EIRFPRTLGPEAKSLLSGLLKKDPKQR 391 L E +R P PE + +P QR Sbjct: 257 CRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR 291 >1U59-A nrPDB Length = 287 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/235 (27%), Positives = 107/235 (45%), Gaps = 14/235 (5%) Query: 156 LGKGTFGKVI--LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 LG G FG V + + + A+K+LK+ K + + E +++ +P++ L Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 75 Query: 214 KYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 Q + L VME A GG L F RE + + A ++ + YL EKN V Sbjct: 76 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL-HQVSMGMKYLE-EKNFV 132 Query: 272 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA--TMKTFCGTP-EYLAPEVLEDNDYGR 328 +RDL N++L + KI+DFGL K D + T ++ P ++ APE + + Sbjct: 133 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 192 Query: 329 AVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRTLGPEAKSLLS 381 D W GV M+E + G+ P+ ++ I + + P PE +L+S Sbjct: 193 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 247 >2OZO-A nrPDB Length = 613 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/235 (27%), Positives = 107/235 (45%), Gaps = 14/235 (5%) Query: 156 LGKGTFGKVI--LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 LG G FG V + + + A+K+LK+ K + + E +++ +P++ L Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 401 Query: 214 KYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 Q + L VME A GG L F RE + + A ++ + YL EKN V Sbjct: 402 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL-HQVSMGMKYLE-EKNFV 458 Query: 272 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA--TMKTFCGTP-EYLAPEVLEDNDYGR 328 +R+L N++L + KI+DFGL K D + T ++ P ++ APE + + Sbjct: 459 HRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 Query: 329 AVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRTLGPEAKSLLS 381 D W GV M+E + G+ P+ ++ I + + P PE +L+S Sbjct: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 >3GQL-A nrPDB Length = 326 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 117/249 (46%), Gaps = 37/249 (14%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR-------YYAMKILKKEVIVAKDEVA 193 P+ R+ + K LG+G FG+V+L + + A+K+LK + + +++ Sbjct: 26 PRDRLVLG-----KPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA--TEKDLS 78 Query: 194 HTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS------------ 240 ++E +++ +H + L + L ++EYA+ G L +L Sbjct: 79 DLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYN 138 Query: 241 -----RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGL 295 E++ S+D ++ ++YL S+K ++RDL N+++ +D +KI DFGL Sbjct: 139 PSHNPEEQLSSKDLVSC-AYQVARGMEYLASKK-CIHRDLAARNVLVTEDNVMKIADFGL 196 Query: 296 CKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ 352 ++ KT G +++APE L D Y D W GV+++E+ G P+ Sbjct: 197 ARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 256 Query: 353 DHEKLFELI 361 E+LF+L+ Sbjct: 257 PVEELFKLL 265 >4E20-A nrPDB Length = 290 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 67/223 (30%), Positives = 98/223 (43%), Gaps = 30/223 (13%) Query: 156 LGKGTFGKVILV----KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLT 211 LG+G FGKV L TG A+K LK+ + E +L+ H + Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGC--GPQLRSGWQREIEILRTLYHEHIV 73 Query: 212 ALKYSF--QTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 K Q + VMEY G L +L R V + + +I + YLH++ + Sbjct: 74 KYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCV-GLAQLLLFAQQICEGMAYLHAQ-H 131 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCK---EG-----IKDGATMKTFCGTPEYLAPEVL 321 ++R L N++LD D +KI DFGL K EG +++ F + APE L Sbjct: 132 YIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF-----WYAPECL 186 Query: 322 EDNDYGRAVDWWGLGVVMYEMM--CGRLPFYNQD-HEKLFELI 361 ++ + A D W GV +YE++ C NQ H K ELI Sbjct: 187 KECKFYYASDVWSFGVTLYELLTYCDS----NQSPHTKFTELI 225 >1LUF-A nrPDB Length = 343 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 63/247 (25%), Positives = 101/247 (40%), Gaps = 43/247 (17%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRY-----YAMKILKKEVIVAKDEVAHTLTENRVL 202 N EY++ +G+G FG+V + Y A+K+LK+E + D A E ++ Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEA--SADMQADFQREAALM 104 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL-----------------SRERVF 245 +P + L +C + EY G+L L +R RV Sbjct: 105 AEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVS 164 Query: 246 SEDRARFYGAE-------IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298 S AE + + + YL SE+ V+RDL N ++ ++ +KI DFGL + Sbjct: 165 SPGPPPLSCAEQLCIARQVAAGMAYL-SERKFVHRDLATRNCLVGENMVVKIADFGLSRN 223 Query: 299 GIK------DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYN 351 DG ++ PE + N Y D W GVV++E+ G P+Y Sbjct: 224 IYSADYYKADGNDAIPI----RWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 279 Query: 352 QDHEKLF 358 HE++ Sbjct: 280 MAHEEVI 286 >3KUL-B nrPDB Length = 325 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 68/249 (27%), Positives = 113/249 (45%), Gaps = 16/249 (6%) Query: 154 KLLGKGTFGKVILVKEKATGRY---YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 K++G G G+V + + G+ A+K LK + + L+E ++ HP + Sbjct: 55 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY--TERQRRDFLSEASIMGQFDHPNI 112 Query: 211 TALKYSFQTHDRLCFVM-EYANGGEL-FFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 L+ T RL ++ EY G L F + + F+ + + + + YL S+ Sbjct: 113 IRLE-GVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYL-SDL 170 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTP-EYLAPEVLEDND 325 V+RDL N+++D + K++DFGL + E D A T P + APE + Sbjct: 171 GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT 230 Query: 326 YGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLG-PEA-KSLLSG 382 + A D W GVVM+E++ G P++N + + + E R P +G P A L+ Sbjct: 231 FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSV-EEGYRLPAPMGCPHALHQLMLD 289 Query: 383 LLKKDPKQR 391 KD QR Sbjct: 290 CWHKDRAQR 298 >4XCU-A nrPDB Length = 300 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 76/273 (27%), Positives = 117/273 (42%), Gaps = 33/273 (12%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATG---------RYYAMKILKKEVIVAKDE 191 P+ R+ + K LG+G FG+V V+ +A G A+K+LK + + Sbjct: 15 PRDRLVLG-----KPLGEGCFGQV--VRAEAFGMDPARPDQASTVAVKMLKDNA--SDKD 65 Query: 192 VAHTLTENRVLQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSED 248 +A ++E V++ RH + L L ++E A G L F R SE Sbjct: 66 LADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEG 125 Query: 249 RARF-----YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG 303 F ++ + YL S K ++RDL N+++ +D +KI DFGL + Sbjct: 126 PLSFPVLVSCAYQVARGMQYLESRK-CIHRDLAARNVLVTEDNVMKIADFGLARGVHHID 184 Query: 304 ATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM-CGRLPFYNQDHEKLFEL 360 KT G +++APE L D Y D W G++++E+ G P+ E+LF L Sbjct: 185 YYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSL 244 Query: 361 ILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQR 391 L E R P PE L+ P QR Sbjct: 245 -LREGHRMDRPPHCPPELYGLMRECWHAAPSQR 276 >6EII-A nrPDB Length = 352 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 89/202 (44%), Gaps = 47/202 (23%) Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTF 309 RFY EI+ ALDY HS +++RD+K N+M+D + +++ D+GL E G Sbjct: 157 RFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVR 214 Query: 310 CGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFY----NQDH---------- 354 + + PE+L D Y ++D W LG ++ M+ + PF+ N D Sbjct: 215 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 274 Query: 355 EKLFELILMEEI----RFPRTLG--------------------PEAKSLLSGLLKKDPKQ 390 E L++ I I RF LG PEA L LL+ D + Sbjct: 275 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 334 Query: 391 RLGGGSEDAKEIMQHRFFAGIV 412 RL A+E M+H +F +V Sbjct: 335 RLT-----AREAMEHPYFYTVV 351 >2RIO-A nrPDB Length = 434 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 72/295 (24%), Positives = 138/295 (46%), Gaps = 56/295 (18%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTA 212 K+LG G+ G V+ G + + K +++ ++A L E ++L S HP + Sbjct: 21 KILGYGSSGTVVF-----QGSFQGRPVAVKRMLIDFCDIA--LMEIKLLTESDDHPNVIR 73 Query: 213 LKYSFQTHDRLCFV-MEYANGGELFFHLSRERVFSEDRARFYGA--------EIVSALDY 263 Y +T DR ++ +E N L + S++ + +I S + + Sbjct: 74 Y-YCSETTDRFLYIALELCNLN--LQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAH 130 Query: 264 LHSEKNVVYRDLKLENLMLDKDGH-------------IKITDFGLCKEGIKDGATMKTF- 309 LHS K +++RDLK +N+++ I I+DFGLCK+ ++ +T Sbjct: 131 LHSLK-IIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNL 189 Query: 310 ---CGTPEYLAPEVLEDND-------YGRAVDWWGLGVVMYEMMC-GRLPF---YNQDHE 355 GT + APE+LE+++ R++D + +G V Y ++ G+ PF Y+++ Sbjct: 190 NNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESN 249 Query: 356 KLFELILMEEIR--FPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + + ++E++ R+L EA L+S ++ DP +R A ++++H F Sbjct: 250 IIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKR-----PTAMKVLRHPLF 299 >1JNK-A nrPDB Length = 423 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 78/327 (23%), Positives = 130/327 (39%), Gaps = 61/327 (18%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + ++ LK +G G G V + R A+K L + + E +++ Sbjct: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCV 118 Query: 206 RHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 H + +L F L VME + L + E +R + +++ Sbjct: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLC 175 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 + +LHS +++RDLK N+++ D +KI DFGL + M + T Y APE Sbjct: 176 GIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPE 233 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELI----------LMEE 365 V+ Y VD W +G +M EM+ ++ F +D+ K+ E + L Sbjct: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 Query: 366 IR-----------------FPRTLGP-----------EAKSLLSGLLKKDPKQRLGGGSE 397 +R FP +L P +A+ LLS +L DP +R+ + Sbjct: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI--SVD 351 Query: 398 DAKEIMQHRFFAGIVWQHVYEKKLSPP 424 DA +QH + VW E + PP Sbjct: 352 DA---LQHPYIN--VWYDPAEVEAPPP 373 >4HZS-A nrPDB Length = 341 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 10/230 (4%) Query: 149 EFEYLKLLGKGTFGKVILVKEKA-TGR--YYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + L+ LG G+FG V + A +G+ A+K LK +V+ + + + E + + Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 72 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYL 264 H L L Y + V E A G L L + + F Y ++ + YL Sbjct: 73 DHRNLIRL-YGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYL 131 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK--DGATMKTFCGTP-EYLAPEVL 321 S K ++RDL NL+L +KI DFGL + + D M+ P + APE L Sbjct: 132 ES-KRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 190 Query: 322 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPR 370 + + A D W GV ++EM G+ P+ + ++ I E R PR Sbjct: 191 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPR 240 >1U54-B nrPDB Length = 291 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/230 (27%), Positives = 101/230 (43%), Gaps = 10/230 (4%) Query: 149 EFEYLKLLGKGTFGKVILVKEKA-TGR--YYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + L+ LG G+FG V + A +G+ A+K LK +V+ + + + E + + Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 78 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYL 264 H L L Y + V E A G L L + + F Y ++ + YL Sbjct: 79 DHRNLIRL-YGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYL 137 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK--DGATMKTFCGTP-EYLAPEVL 321 S K ++RDL NL+L +KI DFGL + + D M+ P + APE L Sbjct: 138 ES-KRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 196 Query: 322 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPR 370 + + A D W GV ++EM G+ P+ + ++ I E R PR Sbjct: 197 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPR 246 >5UIU-A nrPDB Length = 323 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 97/208 (46%), Gaps = 15/208 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL-TENRVLQNSRHPFLTALK 214 +G+G FG ++ K A+K L V + +E+ E +V+ +H L L Sbjct: 55 MGEGGFG--VVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 112 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLS----RERVFSEDRARFY-GAEIVSALDYLHSEKN 269 D LC V Y G L LS + R + GA + +++LH E + Sbjct: 113 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGA--ANGINFLH-ENH 169 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT--FCGTPEYLAPEVLEDNDYG 327 ++RD+K N++LD+ KI+DFGL + K T+ T GT Y+APE L Sbjct: 170 HIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITP 229 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 ++ D + GVV+ E++ G LP ++ E Sbjct: 230 KS-DIYSFGVVLLEIITG-LPAVDEHRE 255 >6F3F-A nrPDB Length = 455 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 112/244 (45%), Gaps = 18/244 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG+G FG+V + T R A+K LK + + L E +V++ RH L L Y Sbjct: 195 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQL-Y 248 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSALDYLHSEKNVVYR 273 + + + + V EY N G L L E + + A+I S + Y+ N V+R Sbjct: 249 AVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVE-RMNYVHR 307 Query: 274 DLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDW 332 DL+ N+++ ++ K+ DFGL + + T + P ++ APE + D Sbjct: 308 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 367 Query: 333 WGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL----KKD 387 W G+++ E+ GR+P+ + ++ + + E + PE L L+ +K+ Sbjct: 368 WSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQCWRKE 424 Query: 388 PKQR 391 P++R Sbjct: 425 PEER 428 >3V5Q-A nrPDB Length = 297 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/266 (24%), Positives = 111/266 (41%), Gaps = 37/266 (13%) Query: 156 LGKGTFGKVIL-----VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 LG+G FGKV L + A+K LK + A+ + E +L N +H + Sbjct: 23 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQR---EAELLTNLQHEHI 79 Query: 211 TALKYSFQTHDRLCFVMEYANGGEL--FF--HLSRERVFSEDRAR------------FYG 254 D L V EY G+L F H + + + R Sbjct: 80 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 139 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK------DGATMKT 308 ++I S + YL S+ + V+RDL N ++ + +KI DFG+ ++ G TM Sbjct: 140 SQIASGMVYLASQ-HFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 198 Query: 309 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEI- 366 ++ PE + + D W GV+++E+ G+ P++ + ++ E I + Sbjct: 199 I----RWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVL 254 Query: 367 RFPRTLGPEAKSLLSGLLKKDPKQRL 392 PR E ++ G +++P+QRL Sbjct: 255 ERPRVCPKEVYDVMLGCWQREPQQRL 280 >4MD7-E nrPDB Length = 391 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 89/203 (43%), Gaps = 49/203 (24%) Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTF 309 RFY EI+ ALDY HS +++RD+K N+M+D + +++ D+GL E G Sbjct: 134 RFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVR 191 Query: 310 CGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI-- 366 + + PE+L D Y ++D W LG ++ M+ + PF+ H+ +L+ + ++ Sbjct: 192 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRIAKVLG 250 Query: 367 -----------------RFPRTLG--------------------PEAKSLLSGLLKKDPK 389 RF LG PEA L LL+ D + Sbjct: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310 Query: 390 QRLGGGSEDAKEIMQHRFFAGIV 412 RL A+E M+H +F +V Sbjct: 311 SRL-----TAREAMEHPYFYTVV 328 >3QD2-B nrPDB Length = 332 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 83/171 (48%), Gaps = 25/171 (14%) Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG------------ 303 +I A+++LHS K +++RDLK N+ D +K+ DFGL +D Sbjct: 172 QIAEAVEFLHS-KGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 230 Query: 304 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 363 AT GT Y++PE + N+Y VD + LG++++E++ ++ E++ + + Sbjct: 231 ATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYS----FSTQMERVRIITDV 286 Query: 364 EEIRFPRTLG---PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 ++FP P+ ++ +L P +R +A +I+++ F + Sbjct: 287 RNLKFPLLFTQKYPQEHMMVQDMLSPSPTER-----PEATDIIENAIFENL 332 Score = 28.1 bits (61), Expect = 8.6, Method: Compositional matrix adjust. Identities = 18/64 (28%), Positives = 31/64 (48%), Gaps = 6/64 (9%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH--TLTENRVLQN 204 + +FE ++ +G+G FG V K K YA+K ++ + E+A + E + L Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIR----LPNRELAREKVMREVKALAK 60 Query: 205 SRHP 208 HP Sbjct: 61 LEHP 64 >5U6C-A nrPDB Length = 315 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 66/257 (25%), Positives = 116/257 (45%), Gaps = 22/257 (8%) Query: 154 KLLGKGTFGKVI---LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 K+LG+G FG V+ L +E T A+K +K + ++ E+ L+E +++ HP + Sbjct: 42 KILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDN-SSQREIEEFLSEAACMKDFSHPNV 100 Query: 211 -----TALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR------ARFYGAEIVS 259 ++ S Q + ++ + G+L +L R+ + + + +I Sbjct: 101 MRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIAL 160 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT--FCGTP-EYL 316 ++YL S +N ++RDL N ML D + + DFGL K+ I G + P +++ Sbjct: 161 GMEYL-SNRNFLHRDLAARNCMLRDDMTVCVADFGLSKK-IYSGDYYRQGRIAKMPVKWI 218 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYN-QDHEKLFELILMEEIRFPRTLGP 374 A E L D Y D W GV M+E+ G P+ Q+HE L+ ++ P Sbjct: 219 AIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLD 278 Query: 375 EAKSLLSGLLKKDPKQR 391 E ++ + DP R Sbjct: 279 ELYEIMYSCWRTDPLDR 295 >3KRL-A nrPDB Length = 335 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 33/222 (14%) Query: 148 NEFEYLKLLGKGTFGKVI------LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 N ++ K LG G FGKV+ L KE A + A+K+LK DE ++E ++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKV-AVKMLKS--TAHADEKEALMSELKI 102 Query: 202 LQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER----------------- 243 + + +H + L + + + EY G+L L R+R Sbjct: 103 MSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQ 162 Query: 244 VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI-KITDFGLCKEGIKD 302 + S D F +++ + +L S KN ++RD+ N++L +GH+ KI DFGL ++ + D Sbjct: 163 LSSRDLLHF-SSQVAQGMAFLAS-KNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMND 219 Query: 303 GA-TMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 +K P +++APE + D Y D W G++++E+ Sbjct: 220 SNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEI 261 >3UIM-A nrPDB Length = 326 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 68/238 (28%), Positives = 102/238 (42%), Gaps = 20/238 (8%) Query: 127 DNSGAEEMEVSLAKPKH------RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180 D E+ EV L + K +V + F +LG+G FGKV + A G A+K Sbjct: 3 DVPAEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKR 61 Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240 LK+E + TE ++ + H L L+ T V Y G + L Sbjct: 62 LKEERTQGGE--LQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCL- 118 Query: 241 RERVFSE------DRARFYGAEIVSALDYLHS--EKNVVYRDLKLENLMLDKDGHIKITD 292 RER S+ R R L YLH + +++RD+K N++LD++ + D Sbjct: 119 RERPESQPPLDWPKRQRIALGS-ARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGD 177 Query: 293 FGLCK-EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 FGL K KD GT ++APE L D +G GV++ E++ G+ F Sbjct: 178 FGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >5U6B-A nrPDB Length = 307 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 60/238 (25%), Positives = 111/238 (46%), Gaps = 26/238 (10%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVI--LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199 +H+V + K LG+G FG V+ + + + A+K +K I + E+ L+E Sbjct: 22 RHKVALG-----KTLGEGEFGAVMEGQLNQDDSILKVAVKTMKI-AICTRSELEDFLSEA 75 Query: 200 RVLQNSRHP-FLTALKYSFQTHDRLCF-----VMEYANGGELFFHLSRERV------FSE 247 ++ HP + + FQ +R F ++ + G+L L R+ Sbjct: 76 VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPT 135 Query: 248 DRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK 307 + A+I S ++YL S K ++RDL N ML+++ + + DFGL K+ I +G + Sbjct: 136 QMLVKFMADIASGMEYL-STKRFIHRDLAARNCMLNENMSVCVADFGLSKK-IYNGDYYR 193 Query: 308 T--FCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 P +++A E L D Y D W GV M+E+ G+ P+ ++ ++++ + Sbjct: 194 QGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYL 251 >2VWV-A nrPDB Length = 302 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 105/227 (46%), Gaps = 18/227 (7%) Query: 149 EFEYLKL---LGKGTFGKVILVKEKATGR---YYAMKILKKEVIVAKDEVAHTLTENRVL 202 + Y+K+ +G G FG+V + KA G+ A+K LK + + L+E ++ Sbjct: 14 DVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGY--TERQRREFLSEASIM 71 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSA 260 HP + L+ + + E+ G L F L+ + F+ + I S Sbjct: 72 GQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQ-FTVIQLVGMLRGIASG 130 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK---EGIKDGATMKTFCG-TP-EY 315 + YL +E + V+RDL N++++ + K++DFGL + E D + G P + Sbjct: 131 MRYL-AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRW 189 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 APE + + A D W G+VM+E+M G P+++ ++ + I Sbjct: 190 TAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI 236 >2W96-B nrPDB Length = 306 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 65/244 (26%), Positives = 108/244 (44%), Gaps = 25/244 (10%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE------VIVAKDEVAHTLTE 198 + + +E + +G G +G V ++ +G + A+K ++ I EVA Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALL--- 57 Query: 199 NRVLQNSRHPFLTALKYSFQTH--DR---LCFVMEYANGG-ELFFHLSRERVFSEDRARF 252 R L+ HP + L T DR + V E+ + + + + + Sbjct: 58 -RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 116 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT 312 + + LD+LH+ +V+RDLK EN+++ G +K+ DFGL + A + T Sbjct: 117 LMRQFLRGLDFLHA-NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LDPVVVT 174 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-----KLFELI-LMEEI 366 Y APEVL + Y VD W +G + EM R P + + E K+F+LI L E Sbjct: 175 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPED 233 Query: 367 RFPR 370 +PR Sbjct: 234 DWPR 237 >3DKO-A nrPDB Length = 318 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 99/214 (46%), Gaps = 7/214 (3%) Query: 154 KLLGKGTFGKVILVKEKATG-RYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 +++G G FG+V + K G R A+ I +V + + L E ++ HP + Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVH 108 Query: 213 LKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 L+ + V+E+ G L F + F+ + I + + YL ++ V Sbjct: 109 LEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL-ADMGYV 167 Query: 272 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP---EYLAPEVLEDNDYGR 328 +RDL N++++ + K++DFGL + D + T G + APE ++ + Sbjct: 168 HRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTS 227 Query: 329 AVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 A D W G+VM+E+M G P+++ ++ + + I Sbjct: 228 ASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI 261 >2OGV-A nrPDB Length = 317 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 103/215 (47%), Gaps = 25/215 (11%) Query: 148 NEFEYLKLLGKGTFGKVI------LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 N ++ K LG G FGKV+ L KE A + A+K+LK DE ++E ++ Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKV-AVKMLKS--TAHADEKEALMSELKI 94 Query: 202 LQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR----------A 250 + + +H + L + + + EY G+L L R+ D+ Sbjct: 95 MSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDL 154 Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI-KITDFGLCKEGIKDGA-TMKT 308 + +++ + +L S KN ++RD+ N++L +GH+ KI DFGL ++ + D +K Sbjct: 155 LHFSSQVAQGMAFLAS-KNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYIVKG 212 Query: 309 FCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 P +++APE + D Y D W G++++E+ Sbjct: 213 NARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEI 247 >2DQ7-X nrPDB Length = 283 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/247 (23%), Positives = 109/247 (44%), Gaps = 12/247 (4%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 + +K LG G FG+V + + A+K LK + + L E ++++ +H Sbjct: 11 LQLIKRLGNGQFGEVWMGTWNGNTKV-AIKTLKPGTMSPES----FLEEAQIMKKLKHDK 65 Query: 210 LTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 L L Y+ + + + V EY N G L F R A++ + + Y+ Sbjct: 66 LVQL-YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE-R 123 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDY 326 N ++RDL+ N+++ KI DFGL + + T + P ++ APE + Sbjct: 124 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 183 Query: 327 GRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLL 384 D W G+++ E++ GR+P+ ++ ++ E + + P+ L+ Sbjct: 184 TIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCW 243 Query: 385 KKDPKQR 391 KKDP++R Sbjct: 244 KKDPEER 250 >2H8H-A nrPDB Length = 535 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 112/244 (45%), Gaps = 18/244 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG+G FG+V + T R A+K LK + + L E +V++ RH L L Y Sbjct: 275 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQL-Y 328 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSALDYLHSEKNVVYR 273 + + + + V EY + G L L E + + A+I S + Y+ N V+R Sbjct: 329 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE-RMNYVHR 387 Query: 274 DLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDW 332 DL+ N+++ ++ K+ DFGL + + T + P ++ APE + D Sbjct: 388 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 447 Query: 333 WGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL----KKD 387 W G+++ E+ GR+P+ + ++ + + E + PE L L+ +K+ Sbjct: 448 WSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQCWRKE 504 Query: 388 PKQR 391 P++R Sbjct: 505 PEER 508 >5EG3-A nrPDB Length = 334 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 63/260 (24%), Positives = 118/260 (45%), Gaps = 31/260 (11%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR-------YYAMKIL 181 +G E E+ PK ++ K LG+G FG+V++ + + A+K+L Sbjct: 17 AGVSEFELP-EDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML 75 Query: 182 KKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240 K + + +++ ++E +++ +H + L + L ++ YA+ G L +L Sbjct: 76 KDDA--TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLR 133 Query: 241 RERV----FSEDRARF------------YGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 R S D R ++ ++YL S+K ++RDL N+++ + Sbjct: 134 ARRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK-CIHRDLAARNVLVTE 192 Query: 285 DGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 + +KI DFGL ++ +T G +++APE L D Y D W GV+M+E+ Sbjct: 193 NNVMKIADFGLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 252 Query: 343 MC-GRLPFYNQDHEKLFELI 361 G P+ E+LF+L+ Sbjct: 253 FTLGGSPYPGIPVEELFKLL 272 >5SYS-A nrPDB Length = 286 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 111/244 (45%), Gaps = 18/244 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG+G FG+ + T R A+K LK + + L E +V++ RH L L Y Sbjct: 26 LGQGCFGECWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQL-Y 79 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSALDYLHSEKNVVYR 273 + + + + V EY + G L L E + + A+I S + Y+ N V+R Sbjct: 80 AVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVE-RMNYVHR 138 Query: 274 DLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDW 332 DL+ N+++ ++ K+ DFGL + + T + P ++ APE + D Sbjct: 139 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 198 Query: 333 WGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL----KKD 387 W G+++ E+ GR+P+ + ++ + + E + PE L L+ +KD Sbjct: 199 WSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQCWRKD 255 Query: 388 PKQR 391 P++R Sbjct: 256 PEER 259 >5L6P-A nrPDB Length = 298 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/251 (24%), Positives = 117/251 (46%), Gaps = 29/251 (11%) Query: 131 AEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR---YYAMKILKKEVIV 187 A+E++VS K + +++G G FG+V + K GR + A+K LK V Sbjct: 13 AKEIDVSCVKIE-----------EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLK--VGY 59 Query: 188 AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVF 245 + + L+E ++ HP + L+ + + E+ L F L+ + F Sbjct: 60 TERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQ-F 118 Query: 246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT 305 + + I + + YL SE N V+RDL N++++ + K++DFGL + ++D + Sbjct: 119 TVIQLVGMLRGIAAGMKYL-SEMNYVHRDLAARNILVNSNLVCKVSDFGLSR-FLEDDPS 176 Query: 306 MKTFCGT------PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLF 358 T+ + + APE + + A D W G+VM+E+M G P+++ ++ + Sbjct: 177 DPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVI 236 Query: 359 ELILMEEIRFP 369 + ++ R P Sbjct: 237 NAV-EQDYRLP 246 >2Y6O-A nrPDB Length = 291 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 99/222 (44%), Gaps = 23/222 (10%) Query: 154 KLLGKGTFGKVILVKEKATGR---YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 K++G G FG+V + K G+ A+K LK + L+E ++ HP + Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGY--TDKQRRDFLSEASIMGQFDHPNI 77 Query: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV-------SALDY 263 L+ + + EY G L + ++ RF ++V S + Y Sbjct: 78 IHLEGVVTKCKPVMIITEYMENGSL------DAFLRKNDGRFTVIQLVGMLRGIGSGMKY 131 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP---EYLAPEV 320 L S+ + V+RDL N++++ + K++DFG+ + D T G + APE Sbjct: 132 L-SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEA 190 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 + + A D W G+VM+E+M G P+++ ++ + + I Sbjct: 191 IAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI 232 >2I6L-A nrPDB Length = 320 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 99/234 (42%), Gaps = 35/234 (14%) Query: 153 LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH----- 207 LK LG G G V + + A +KK V+ V H L E ++++ H Sbjct: 16 LKPLGCGGNGLVFSAVDNDCDKRVA---IKKIVLTDPQSVKHALREIKIIRRLDHDNIVK 72 Query: 208 ---------PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 LT S + + V EY ++ + E+ AR + +++ Sbjct: 73 VFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETD--LANVLEQGPLLEEHARLFMYQLL 130 Query: 259 SALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLC---------KEGIKDGATMKT 308 L Y+HS NV++RDLK NL ++ +D +KI DFGL K + +G K Sbjct: 131 RGLKYIHS-ANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKW 189 Query: 309 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 362 + L+P N+Y +A+D W G + EM+ G+ F + +LIL Sbjct: 190 YRSPRLLLSP-----NNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLIL 238 >5AR8-A nrPDB Length = 326 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 91/210 (43%), Gaps = 14/210 (6%) Query: 153 LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 L+ L +G G V + A+K L + E L E +L +R ++ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED----RARFYGAEIVSALDYLHS-E 267 + + L V EY G L L R+ + + R R EI ++YLH+ Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILH-EIALGVNYLHNMT 155 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE-----YLAPEVLE 322 +++ DLK +N++LD + H+KI DFGL K + + ++ PE Y+ PE E Sbjct: 156 PPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYE 215 Query: 323 DNDYGRAV---DWWGLGVVMYEMMCGRLPF 349 RA D + V+ +E++ + PF Sbjct: 216 PGQKSRASIKHDIYSYAVITWEVLSRKQPF 245 >5J0A-A nrPDB Length = 300 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 96/218 (44%), Gaps = 20/218 (9%) Query: 152 YLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-----LTENRVLQNSR 206 +++ LG GT V L+K G ++ +KK + D + E ++L++ Sbjct: 13 FMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLH 72 Query: 207 HPFLTALKYSFQTHD-RLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS------ 259 HP + + + +D LC MEY GGE + E + + F A I+ Sbjct: 73 HPNIVGYRAFTEANDGSLCLAMEY--GGEKSLNDLIEERYKASQDPFPAAIILKVALNMA 130 Query: 260 -ALDYLHSEKNVVYRDLKLENLMLDKDGH-IKITDFGLC---KEGIKDGATMKTFCGTPE 314 L YLH EK +++ D+K N+++ D IKI D G+ E ++ + GT Sbjct: 131 RGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEP 190 Query: 315 YLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYN 351 + E +E+N D + G+ ++EMM +P N Sbjct: 191 WKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHIN 228 >4AT3-A nrPDB Length = 299 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 64/262 (24%), Positives = 109/262 (41%), Gaps = 34/262 (12%) Query: 156 LGKGTFGKVILVK-----EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 LG+G FGKV L + + A+K LK A+ + E +L N +H + Sbjct: 21 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHR---EAELLTNLQHEHI 77 Query: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSRE-------------RVFSEDRARFYGAEI 257 D L V EY G+L L ++ + +I Sbjct: 78 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI 137 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK------DGATMKTFCG 311 + + YL S+ + V+RDL N ++ ++ +KI DFG+ ++ G TM Sbjct: 138 AAGMVYLASQ-HFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI-- 194 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEI-RFP 369 ++ PE + + D W LGVV++E+ G+ P+Y + ++ E I + + P Sbjct: 195 --RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRP 252 Query: 370 RTLGPEAKSLLSGLLKKDPKQR 391 RT E L+ G +++P R Sbjct: 253 RTCPQEVYELMLGCWQREPHMR 274 >1JPA-A nrPDB Length = 312 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 105/227 (46%), Gaps = 16/227 (7%) Query: 154 KLLGKGTFGKVILVKEKATGR---YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 +++G G FG+V K G+ + A+K LK + + L+E ++ HP + Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY--TEKQRRDFLSEASIMGQFDHPNV 96 Query: 211 TALKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 L+ + + E+ G L F + F+ + I + + YL ++ N Sbjct: 97 IHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL-ADMN 155 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT------PEYLAPEVLED 323 V+RDL N++++ + K++DFGL + ++D + T+ + APE ++ Sbjct: 156 YVHRDLAARNILVNSNLVCKVSDFGLSR-FLEDDTSDPTYTSALGGKIPIRWTAPEAIQY 214 Query: 324 NDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFP 369 + A D W G+VM+E+M G P+++ ++ + I ++ R P Sbjct: 215 RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLP 260 >5UNP-A nrPDB Length = 369 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 69/269 (25%), Positives = 111/269 (41%), Gaps = 46/269 (17%) Query: 150 FEYLKLLGKGTFGKVI-LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ--NSR 206 +E + LG+GTFG+V+ V + G A+KI+K V K + A L N VL+ N + Sbjct: 36 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKN---VEKYKEAARLEIN-VLEKINEK 91 Query: 207 HP----FLTALKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFSEDRARFYGAEIVSAL 261 P + F H +C E F + + + R ++ A+ Sbjct: 92 DPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAV 151 Query: 262 DYLHSEKNVVYRDLKLENLMLD-------------------KDGHIKITDFGLCKEGIKD 302 +LH K + + DLK EN++ K +++ DFG D Sbjct: 152 KFLHDNK-LTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG---SATFD 207 Query: 303 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 362 T T Y APEV+ + + + D W +G +++E G F Q H+ L + Sbjct: 208 HEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLF--QTHDNREHLAM 265 Query: 363 MEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 ME R LGP + S +++K KQ+ Sbjct: 266 ME-----RILGP----IPSRMIRKTRKQK 285 >3FI2-A nrPDB Length = 353 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 75/316 (23%), Positives = 126/316 (39%), Gaps = 61/316 (19%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + ++ LK +G G G V + R A+K L + + E +++ Sbjct: 22 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCV 80 Query: 206 RHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 H + +L F L VME + L + E +R + +++ Sbjct: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLC 137 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 + +LHS +++RDLK N+++ D +KI DFGL + M + T Y APE Sbjct: 138 GIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPE 195 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELI----------LMEE 365 V+ Y VD W +G +M EM+ ++ F +D+ K+ E + L Sbjct: 196 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 255 Query: 366 IR-----------------FPRTLGP-----------EAKSLLSGLLKKDPKQRLGGGSE 397 +R FP +L P +A+ LLS +L DP +R+ + Sbjct: 256 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI--SVD 313 Query: 398 DAKEIMQHRFFAGIVW 413 DA +QH + VW Sbjct: 314 DA---LQHPYIN--VW 324 >4XLV-A nrPDB Length = 328 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 65/263 (24%), Positives = 114/263 (43%), Gaps = 24/263 (9%) Query: 120 FRSGSPSDNSGAEEMEVSLAKPKH-RVTMNEFEYLKLLGKGTFGKVI------LVKEKAT 172 F S +P S ++ S+ P V+ + L+ LG+G+FG V ++K +A Sbjct: 10 FASSNPEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAE 69 Query: 173 GRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANG 232 R A+K + + + E L E V++ + L VME Sbjct: 70 TRV-AVKTVNESASLR--ERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAH 126 Query: 233 GELFFHLSRERVFSEDRARF----------YGAEIVSALDYLHSEKNVVYRDLKLENLML 282 G+L +L R +E+ AEI + YL+++K V+RDL N M+ Sbjct: 127 GDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKK-FVHRDLAARNCMV 185 Query: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMY 340 D +KI DFG+ ++ + K G ++APE L+D + + D W GVV++ Sbjct: 186 AHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLW 245 Query: 341 EMMC-GRLPFYNQDHEKLFELIL 362 E+ P+ +E++ + ++ Sbjct: 246 EITSLAEQPYQGLSNEQVLKFVM 268 >5GRN-A nrPDB Length = 356 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 57/231 (24%), Positives = 103/231 (44%), Gaps = 38/231 (16%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAK-----DEVAHTLTENRVLQN-SRH 207 ++LG G FGKV V+ A G + ++K V + K E ++E +++ + H Sbjct: 52 RVLGSGAFGKV--VEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPH 109 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEI-------- 257 + L + + + EY G+L + H +R+ S + +E+ Sbjct: 110 LNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDN 169 Query: 258 ---VSALDYLH------------SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD 302 ++ LD L + KN V+RDL N++L + +KI DFGL ++ + D Sbjct: 170 SEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHD 229 Query: 303 GATM---KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 349 + TF +++APE + DN Y D W G++++E+ G P+ Sbjct: 230 SNYVSKGSTFLPV-KWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPY 279 >5LPZ-A nrPDB Length = 332 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 94/214 (43%), Gaps = 12/214 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 N F L+G G FG V KA + + +KK + V+ + E + +H Sbjct: 17 NGFHNDSLIGSGGFGDVY----KAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKH 72 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSA--LDY 263 L L + D V E+ G L H ++ + + I SA L + Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 264 LH--SEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPE 319 LH ++++RD+K N++LD++ +++DFG+ + + ++ T GTP Y+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353 + D + GVV+ E++ G+ P + D Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPD 226 >5IKW-A nrPDB Length = 310 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 72/301 (23%), Positives = 126/301 (41%), Gaps = 58/301 (19%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEK-----ATGRYYA-----MKILKKEVIV 187 A +H+VT+ E L +G F V LV+ A R Y + + K+E+ + Sbjct: 9 FAVGRHQVTLEES-----LAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITI 63 Query: 188 AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVF 245 K+ H +N A+ + +MEY G++ +++ + F Sbjct: 64 MKELSGH--------KNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGF 115 Query: 246 SEDRARFYGAEIVSALDYLHSEKN-VVYRDLKLENLMLDKDGHIKITDFGLCKEGI---- 300 +E + A+ LH K +++RDLK+EN++L+ G+ + DFG Sbjct: 116 TEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQ 175 Query: 301 KDGAT-----MKTFCGTPEYLAPEVLEDNDYG-----RAVDWWGLGVVMYEMMCGRLPFY 350 KDG +K + T Y APE++ N YG D W LG ++Y++ LPF Sbjct: 176 KDGVNVVEEEIKKY-TTLSYRAPEMI--NLYGGKPITTKADIWALGCLLYKLCFFTLPF- 231 Query: 351 NQDHEKLFE--LILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + + + + + R+ R + L+ +L+ DP+ R +I Q +F Sbjct: 232 GESQVAICDGNFTIPDNSRYSRNI----HCLIRFMLEPDPEHR--------PDIFQVSYF 279 Query: 409 A 409 A Sbjct: 280 A 280 >6GQK-A nrPDB Length = 328 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 68/272 (25%), Positives = 112/272 (41%), Gaps = 32/272 (11%) Query: 148 NEFEYLKLLGKGTFGKVI------LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 N + K LG G FGKV+ L+K A A+K+LK + E ++E +V Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDA-AMTVAVKMLKPSAHSTEREA--LMSELKV 97 Query: 202 LQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-------VFSEDRAR-- 251 L H + L + + EY G+L L R+R V ED + Sbjct: 98 LSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDF 157 Query: 252 -------FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 304 + ++ + +L S KN ++RDL N++L KI DFGL ++ D Sbjct: 158 LTLEHLLSFSYQVAKGMAFLAS-KNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSN 216 Query: 305 TM-KTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 + K P +++APE + ++ Y D W G+ ++E+ G P+ + F + Sbjct: 217 YVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKM 276 Query: 362 LMEEIRF--PRTLGPEAKSLLSGLLKKDPKQR 391 + E R P E ++ DP +R Sbjct: 277 IKEGFRMSSPEYAPAEMYDIMKTCWDADPDKR 308 >5OAT-A nrPDB Length = 411 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 20/161 (12%) Query: 270 VVYRDLKLENLMLD----KDGHIKITDFGLCKEGIKDGATMKTFC------GTPEYLAPE 319 + +RDLK +NL+LD + + I+DFG C +G ++ G +APE Sbjct: 174 IAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPE 233 Query: 320 VLEDN-------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL 372 ++ +Y +A D W +G + YE+ PFY K F + + P + Sbjct: 234 IICQKPGTFSVLNYSKA-DLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEV 292 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413 ++L++ LLK++P +RL E A + Q +A W Sbjct: 293 PTVIQALVANLLKRNPNKRL--DPEVAANVCQLFLWAPSTW 331 >5LPV-A nrPDB Length = 296 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 94/214 (43%), Gaps = 12/214 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 N F L+G G FG V KA + + +KK + V+ + E + +H Sbjct: 17 NGFHNDSLIGSGGFGDVY----KAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKH 72 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSA--LDY 263 L L + D V E+ G L H ++ + + I SA L + Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 264 LH--SEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPE 319 LH ++++RD+K N++LD++ +++DFG+ + + ++ T GTP Y+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353 + D + GVV+ E++ G+ P + D Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPD 226 >2H34-A nrPDB Length = 309 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 60/260 (23%), Positives = 109/260 (41%), Gaps = 11/260 (4%) Query: 139 AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT- 197 A+ + + +L+G+G G V ++ R A+K++ + ++ D V T Sbjct: 25 AESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSE--TLSSDPVFRTRMQ 82 Query: 198 -ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 E R + P + + + +L M NG +L L R+ + RA + Sbjct: 83 REARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQ 142 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT-MKTFCGTPEY 315 I SAL +RD+K EN+++ D + DFG+ + T + GT Y Sbjct: 143 IGSAL-DAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYY 201 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE 375 +APE ++ D + L V+YE + G P Y D + + + I P T+ P Sbjct: 202 MAPERFSESHATYRADIYALTCVLYECLTGSPP-YQGDQLSVMGAHINQAIPRPSTVRPG 260 Query: 376 A----KSLLSGLLKKDPKQR 391 ++++ + K+P+ R Sbjct: 261 IPVAFDAVIARGMAKNPEDR 280 >4R7H-A nrPDB Length = 343 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 59/228 (25%), Positives = 105/228 (46%), Gaps = 38/228 (16%) Query: 148 NEFEYLKLLGKGTFGKVI------LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 N ++ K LG G FGKV+ L KE A + A+K+LK DE ++E ++ Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKV-AVKMLKS--TAHADEKEALMSELKI 106 Query: 202 LQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR----------------ERV 244 + + +H + L + + + EY G+L L R E + Sbjct: 107 MSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGL 166 Query: 245 FSEDRARF-------YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI-KITDFGLC 296 ED + +++ + +L S KN ++RD+ N++L +GH+ KI DFGL Sbjct: 167 DKEDGRPLELRDLLHFSSQVAQGMAFLAS-KNCIHRDVAARNVLL-TNGHVAKIGDFGLA 224 Query: 297 KEGIKDGA-TMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 ++ + D +K P +++APE + D+ Y D W G++++E+ Sbjct: 225 RDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEI 272 >3A4O-X nrPDB Length = 286 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 100/224 (44%), Gaps = 13/224 (5%) Query: 153 LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 +K LG G FG+V + + + A+K LK + V L E +++ +H L Sbjct: 18 VKRLGAGQFGEVWMGYYNNSTKV-AVKTLKPGTM----SVQAFLEEANLMKTLQHDKLVR 72 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRE---RVFSEDRARFYGAEIVSALDYLHSEKN 269 L + + + EY G L L + +V F A+I + Y+ KN Sbjct: 73 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDF-SAQIAEGMAYIE-RKN 130 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGR 328 ++RDL+ N+++ + KI DFGL + + T + P ++ APE + + Sbjct: 131 YIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTI 190 Query: 329 AVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRT 371 D W G+++YE++ G++P+ + + + L + R PR Sbjct: 191 KSDVWSFGILLYEIVTYGKIPYPGRTNADVMT-ALSQGYRMPRV 233 >2BUJ-A nrPDB Length = 317 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 69/277 (24%), Positives = 118/277 (42%), Gaps = 35/277 (12%) Query: 143 HRVTMNEFEYLKL--LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 H V ++ YL + LG+G F V LV+ G +YA+K + ++E +R Sbjct: 22 HMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHR 81 Query: 201 VLQNSRHP-FLTALKYSFQ---THDRLCFVMEYANGGELFFHLSRER----VFSEDRARF 252 + HP L + Y + ++ + G L+ + R + +ED+ + Sbjct: 82 LFN---HPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILW 138 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG------LCKEGIKDGATM 306 I L+ +H+ K +RDLK N++L +G + D G + EG + T+ Sbjct: 139 LLLGICRGLEAIHA-KGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTL 197 Query: 307 KTFCG---TPEYLAPEVLEDNDY---GRAVDWWGLGVVMYEMMCGRLPFYNQDHEK--LF 358 + + T Y APE+ + D W LG V+Y MM G P Y+ +K Sbjct: 198 QDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGP-YDMVFQKGDSV 256 Query: 359 ELILMEEIRFPRTLGPEAKS----LLSGLLKKDPKQR 391 L + ++ P++ P S LL+ ++ DP QR Sbjct: 257 ALAVQNQLSIPQS--PRHSSALWQLLNSMMTVDPHQR 291 >5MJB-A nrPDB Length = 305 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 59/250 (23%), Positives = 114/250 (45%), Gaps = 27/250 (10%) Query: 131 AEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR---YYAMKILKKEVIV 187 A+E++VS K + +++G G FG+V + K G+ Y A+K LK Sbjct: 20 AKEIDVSFVKIE-----------EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-- 66 Query: 188 AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFS 246 ++ + L+E ++ H + L+ + + E+ L F + F+ Sbjct: 67 SEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFT 126 Query: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306 + I + + YL SE N V+RDL N++++ + K++DFGL + ++D + Sbjct: 127 VIQLVGMLRGIAAGMKYL-SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRY-LQDDTSD 184 Query: 307 KTFCGT------PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFE 359 T+ + + APE + + A D W G+VM+E+M G P+++ ++ + Sbjct: 185 PTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVIN 244 Query: 360 LILMEEIRFP 369 I ++ R P Sbjct: 245 AI-EQDYRLP 253 >4Y83-A nrPDB Length = 332 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 47/195 (24%), Positives = 82/195 (42%), Gaps = 10/195 (5%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 + +G FGKV L ++ T + A K++ + D + RH + L Sbjct: 80 FIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDV--------EIQACFRHENIAELY 131 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 + + + ME GG + L E + ++ LD+LHS+K V++ D Sbjct: 132 GAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKK-VIHHD 190 Query: 275 LKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 334 +K N++ + + DFGL + +D K GT Y++PEV+ + D + Sbjct: 191 IKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYS 249 Query: 335 LGVVMYEMMCGRLPF 349 LG + M G P+ Sbjct: 250 LGATLIHMQTGTPPW 264 >2Y4I-B nrPDB Length = 319 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 104/232 (44%), Gaps = 27/232 (11%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYY---AMKILKKEVIVAKDEVAHTLTENRV 201 + + E +L+GKG FG+V GR++ A++++ E +D++ E Sbjct: 30 IPFEQLEIGELIGKGRFGQVY------HGRWHGEVAIRLIDIER-DNEDQLKAFKREVMA 82 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSA 260 + +RH + + + L + G L+ + + V ++ R EIV Sbjct: 83 YRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKG 142 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK-EGIKDGA----TMKTFCGTPEY 315 + YLH+ K ++++DLK +N+ D +G + ITDFGL G+ ++ G + Sbjct: 143 MGYLHA-KGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCH 200 Query: 316 LAPEVL--------EDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 358 LAPE++ ED + + D + LG + YE+ PF Q E + Sbjct: 201 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAII 252 >6FEX-A nrPDB Length = 321 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 61/239 (25%), Positives = 100/239 (41%), Gaps = 40/239 (16%) Query: 156 LGKGTFGKVILVK----------------EKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199 LG+G FG+V L + K A+KIL+ + K+ L E Sbjct: 24 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA--TKNARNDFLKEV 81 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRAR-------- 251 +++ + P + L D LC + +Y G+L LS ++ ED+A Sbjct: 82 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL--EDKAAEGAPGDPT 139 Query: 252 -------FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK-DG 303 A+I S + YL + N V+RDL N ++ ++ IKI DFG+ + D Sbjct: 140 ISYPMLLHVAAQIASGMRYL-ATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDY 198 Query: 304 ATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYE--MMCGRLPFYNQDHEKLFE 359 ++ P ++A E + + A D W GV ++E M+C PF E++ E Sbjct: 199 YRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIE 257 >3BBT-B nrPDB Length = 328 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 93/209 (44%), Gaps = 23/209 (11%) Query: 148 NEFEYLKLLGKGTFGKV---ILVKEKATGRY-YAMKILKKEVIVAKDEVAHTLTENRVLQ 203 E + +K+LG G FG V I V E T + A+KIL E K V + E ++ Sbjct: 15 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN-ETTGPKANVEF-MDEALIMA 72 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSAL 261 + HP L L + V + G L + H ++ + S+ + +I + Sbjct: 73 SMDHPHLVRL-LGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN-WCVQIAKGM 130 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC-------KEGIKDGATMKTFCGTPE 314 YL E+ +V+RDL N+++ H+KITDFGL KE DG M + Sbjct: 131 MYL-EERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPI-----K 184 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343 ++A E + + D W GV ++E+M Sbjct: 185 WMALECIHYRKFTHQSDVWSYGVTIWELM 213 >1AD5-A nrPDB Length = 438 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/226 (23%), Positives = 100/226 (44%), Gaps = 23/226 (10%) Query: 151 EYLKL---LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 E LKL LG G FG+V + + A+K +K + V L E V++ +H Sbjct: 182 ESLKLEKKLGAGQFGEVWMATYNKHTKV-AVKTMKPGSM----SVEAFLAEANVMKTLQH 236 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF--YGAEIVSALDYLH 265 L L ++ T + + + E+ G L L + + + + A+I + ++ Sbjct: 237 DKLVKL-HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 295 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 ++N ++RDL+ N+++ KI DFGL + G K ++ APE + Sbjct: 296 -QRNYIHRDLRAANILVSASLVCKIADFGLARVGAKFPI---------KWTAPEAINFGS 345 Query: 326 YGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPR 370 + D W G+++ E++ GR+P+ + ++ L R PR Sbjct: 346 FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIR-ALERGYRMPR 390 >4LFI-A nrPDB Length = 374 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 88/201 (43%), Gaps = 47/201 (23%) Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTF 309 RFY E++ ALDY HS +++RD+K N+M+D K+ +++ D+GL E Sbjct: 175 RFYMFELLKALDYCHS-MGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVR 232 Query: 310 CGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYN--QDHEKLFELI----- 361 + + PE+L D Y ++D W G ++ M+ R PF++ + ++L +++ Sbjct: 233 VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT 292 Query: 362 -------LMEEIRFPRTL------------------------GPEAKSLLSGLLKKDPKQ 390 L EI PR E L+ LL+ D ++ Sbjct: 293 SDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQE 352 Query: 391 RLGGGSEDAKEIMQHRFFAGI 411 RL AKE M H +FA I Sbjct: 353 RLT-----AKEAMGHPWFAPI 368 >3EB0-A nrPDB Length = 383 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/197 (26%), Positives = 90/197 (45%), Gaps = 38/197 (19%) Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIK 301 R + Y ++ A+ ++HS + +RD+K +NL+++ KD +K+ DFG K+ I Sbjct: 136 RSIPMNLISIYIYQLFRAVGFIHS-LGICHRDIKPQNLLVNSKDNTLKLCDFGSAKKLIP 194 Query: 302 DGATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH-EKLFE 359 ++ C Y APE+ L +Y ++D W +G V E++ G+ F + ++L Sbjct: 195 SEPSVAYICSR-FYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSIDQLVR 253 Query: 360 LILM----------------EEIRFP-------RTLGPE-----AKSLLSGLLKKDPKQR 391 +I + E+RFP R + PE A LL +L+ +P R Sbjct: 254 IIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDLLEQILRYEPDLR 313 Query: 392 LGGGSEDAKEIMQHRFF 408 + + E M H FF Sbjct: 314 I-----NPYEAMAHPFF 325 >2HK5-A nrPDB Length = 270 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 95/206 (46%), Gaps = 14/206 (6%) Query: 151 EYLKL---LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 E LKL LG G FG+V + AT + K+ K + V L E V++ +H Sbjct: 15 ESLKLEKKLGAGQFGEVWM----ATYNKHT-KVAVKTMKPGSMSVEAFLAEANVMKTLQH 69 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF--YGAEIVSALDYLH 265 L L ++ T + + + E+ G L L + + + + A+I + ++ Sbjct: 70 DKLVKL-HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 128 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDN 324 ++N ++RDL+ N+++ KI DFGL + + T + P ++ APE + Sbjct: 129 -QRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG 187 Query: 325 DYGRAVDWWGLGVVMYEMMC-GRLPF 349 + D W G+++ E++ GR+P+ Sbjct: 188 SFTIKSDVWSFGILLMEIVTYGRIPY 213 >5WNL-A nrPDB Length = 342 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 66/261 (25%), Positives = 117/261 (44%), Gaps = 24/261 (9%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 EF + +G G FG+V V+ + A+K + V E L E + ++ ++ Sbjct: 20 GEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKC-SPSLHVDDRERMELLEEAKKMEMAK- 77 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS- 266 F L + + VMEY G L L+ E + + R R E +++LH Sbjct: 78 -FRYILPVYGICQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIV-HETAVGMNFLHCM 135 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCK-EGIKDG--ATMKTFCGTPEYLAPEVLED 323 +++ +LK N++LD H+KI+DFGL K G+ +M GT YL PE + + Sbjct: 136 SPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIRE 195 Query: 324 ND--YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIR-----FPRTLGPEA 376 + D + +V++ ++ + PF + EK I+M+ ++ P P Sbjct: 196 KSRLFDTKHDVYSFAIVIWGVLTQKKPFAD---EKNILHIMMKVVKGHRPELPPICRPRP 252 Query: 377 KSLLS--GLLKK----DPKQR 391 ++ S GL+++ DP+ R Sbjct: 253 RACASLIGLMQRCWHADPQVR 273 >2PL0-A nrPDB Length = 289 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 92/207 (44%), Gaps = 16/207 (7%) Query: 151 EYLKL---LGKGTFGKVILVKEKATGRYYA-MKILKKEVIVAKDEVAHTLTENRVLQNSR 206 E LKL LG G FG+V + G Y K+ K + L E +++ + Sbjct: 23 ETLKLVERLGAGQFGEVWM------GYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQ 76 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDYL 264 H L L Y+ T + + + EY G L F + ++ A+I + ++ Sbjct: 77 HQRLVRL-YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI 135 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLED 323 E+N ++RDL+ N+++ KI DFGL + + T + P ++ APE + Sbjct: 136 E-ERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINY 194 Query: 324 NDYGRAVDWWGLGVVMYEMMC-GRLPF 349 + D W G+++ E++ GR+P+ Sbjct: 195 GTFTIKSDVWSFGILLTEIVTHGRIPY 221 >4PDO-A nrPDB Length = 299 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 95/215 (44%), Gaps = 8/215 (3%) Query: 154 KLLGKGTFGKVI--LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLT 211 K++G G FG+V ++K + + + I + + + L E ++ H + Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNII 99 Query: 212 ALKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNV 270 L+ + + + EY G L F ++ FS + I + + YL + N Sbjct: 100 RLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYL-ANMNY 158 Query: 271 VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP---EYLAPEVLEDNDYG 327 V+RDL N++++ + K++DFGL + D T G + APE + + Sbjct: 159 VHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFT 218 Query: 328 RAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 A D W G+VM+E+M G P++ + ++ + I Sbjct: 219 SASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI 253 >4FL3-A nrPDB Length = 635 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 89/211 (42%), Gaps = 27/211 (12%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMK---------ILKKEV--IVAKDEVAHTLTENRVL 202 K LG G FG V YY MK ILK E KDE+ L E V+ Sbjct: 375 KELGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKDEL---LAEANVM 424 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 Q +P++ + + VME A G L +L + R + ++ + Sbjct: 425 QQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK--TFCGTP-EYLAPE 319 YL E N V+RDL N++L + KI+DFGL K D K T P ++ APE Sbjct: 484 YL-EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 349 + + D W GV+M+E G+ P+ Sbjct: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 >2R2P-A nrPDB Length = 295 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 18/230 (7%) Query: 154 KLLGKGTFGKVILVKEKATGRY---YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 +++G G FG+V + K G+ A+K LK V + + L E ++ HP + Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLK--VGYTEKQRRDFLGEASIMGQFDHPNI 85 Query: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALDYLHSEKN 269 L+ + V EY G L L + + F+ + I + + YL S+ Sbjct: 86 IHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYL-SDMG 144 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP---EYLAPEVLEDNDY 326 V+RDL N++++ + K++DFGL + D T G + APE + + Sbjct: 145 YVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKF 204 Query: 327 GRAVDWWGLGVVMYEMMC-GRLPFY---NQDHEKLFELILMEEIRFPRTL 372 A D W G+VM+E++ G P++ NQD K E E R P + Sbjct: 205 TSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE----EGYRLPSPM 250 >1PY5-A nrPDB Length = 326 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 65/233 (27%), Positives = 99/233 (42%), Gaps = 50/233 (21%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS--RHP----F 209 +GKG FG+V + K G A+KI E E + Q RH F Sbjct: 37 IGKGRFGEVW--RGKWRGEEVAVKIFSSR------EERSWFREAEIYQTVMLRHENILGF 88 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE-- 267 + A T +L V +Y G LF +L+R V E + S L +LH E Sbjct: 89 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKL-ALSTASGLAHLHMEIV 147 Query: 268 -----KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF-------CGTPEY 315 + +RDLK +N+++ K+G I D GL ++ + T GT Y Sbjct: 148 GTQGKPAIAHRDLKSKNILVKKNGTCCIADLGL---AVRHDSATDTIDIAPNHRVGTKRY 204 Query: 316 LAPEVLEDN-------DYGRAVDWWGLGVVMYEMM--CG--------RLPFYN 351 +APEVL+D+ + RA D + +G+V +E+ C +LP+Y+ Sbjct: 205 MAPEVLDDSINMKHFESFKRA-DIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 256 >3HNG-A nrPDB Length = 360 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 41/144 (28%), Positives = 72/144 (50%), Gaps = 6/144 (4%) Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD-GATMKTFCG 311 Y ++ +++L S K ++RDL N++L ++ +KI DFGL ++ K+ K Sbjct: 204 YSFQVARGMEFLSSRK-CIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTR 262 Query: 312 TP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRF- 368 P +++APE + D Y D W GV+++E+ G P+ ++ F L E +R Sbjct: 263 LPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMR 322 Query: 369 -PRTLGPEAKSLLSGLLKKDPKQR 391 P PE ++ +DPK+R Sbjct: 323 APEYSTPEIYQIMLDCWHRDPKER 346 Score = 34.7 bits (78), Expect = 0.092, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 9/97 (9%) Query: 154 KLLGKGTFGKVIL-----VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 K LG+G FGKV+ +K+ T R A+K+LK+ + E +TE ++L + H Sbjct: 33 KSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATAS--EYKALMTELKILTHIGHH 90 Query: 209 F--LTALKYSFQTHDRLCFVMEYANGGELFFHLSRER 243 + L + L ++EY G L +L +R Sbjct: 91 LNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKR 127 >2PVN-A nrPDB Length = 352 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 88/201 (43%), Gaps = 47/201 (23%) Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD-GHIKITDFGLCKEGIKDGATMKTF 309 R+Y E++ ALDY HS+ +++RD+K N+M+D + +++ D+GL E G Sbjct: 149 RYYIYELLKALDYCHSQ-GIMHRDVKPHNVMIDHELRKLRLIDWGLA-EFYHPGKEYNVR 206 Query: 310 CGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFY--NQDHEKL--------- 357 + + PE+L D DY ++D W LG + M+ + PF+ + +H++L Sbjct: 207 VASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGT 266 Query: 358 -----------------FELILMEEIRFP----------RTLGPEAKSLLSGLLKKDPKQ 390 E ++ R P + PEA L LL+ D ++ Sbjct: 267 DGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQE 326 Query: 391 RLGGGSEDAKEIMQHRFFAGI 411 RL A E M H +F + Sbjct: 327 RLT-----ALEAMTHPYFQQV 342 >3Q4U-A nrPDB Length = 301 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 96/224 (42%), Gaps = 34/224 (15%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA---HTLTEN 199 R + L+ +GKG +G+V + G A+KI ++DE + T N Sbjct: 3 QRTVARDITLLECVGKGRYGEVW--RGSWQGENVAVKIFS-----SRDEKSWFRETELYN 55 Query: 200 RVLQNSRHP----FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 V+ RH F+ + S + +L + Y G L+ +L + + R Sbjct: 56 TVML--RHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIV-L 112 Query: 256 EIVSALDYLHSE-------KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT 308 I S L +LH E + +RDLK +N+++ K+G I D GL + + Sbjct: 113 SIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDV 172 Query: 309 F----CGTPEYLAPEVLEDN------DYGRAVDWWGLGVVMYEM 342 GT Y+APEVL++ D + VD W G+V++E+ Sbjct: 173 GNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV 216 >5C26-A nrPDB Length = 299 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 89/211 (42%), Gaps = 27/211 (12%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMK---------ILKKEVI--VAKDEVAHTLTENRVL 202 K LG G FG V YY MK ILK E KDE+ L E V+ Sbjct: 33 KELGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKDEL---LAEANVM 82 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 Q +P++ + + VME A G L +L + R + ++ + Sbjct: 83 QQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 141 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK--TFCGTP-EYLAPE 319 YL E N V+RDL N++L + KI+DFGL K D K T P ++ APE Sbjct: 142 YLE-ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 200 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 349 + + D W GV+M+E G+ P+ Sbjct: 201 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 231 >4P5Q-A nrPDB Length = 361 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 100/223 (44%), Gaps = 25/223 (11%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKI-LKKEVIVAKD--EVAHT-------LTENRVLQ 203 K++G G FG+V +GR +K+ KKE+ VA +V +T L E ++ Sbjct: 39 KVVGAGEFGEV------CSGR---LKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMG 89 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALD 262 HP + L+ + V EY G L L + F+ + I S + Sbjct: 90 QFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMK 149 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP---EYLAPE 319 YL S+ V+RDL N++++ + K++DFGL + D T G + +PE Sbjct: 150 YL-SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPE 208 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 + + A D W G+V++E+M G P++ ++ + + + Sbjct: 209 AIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAV 251 >6BSD-A nrPDB Length = 876 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/265 (23%), Positives = 106/265 (40%), Gaps = 46/265 (17%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK----------------EKATGRYYAMK 179 V P+ + + + LG+G FG+V L + K A+K Sbjct: 559 VGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVK 618 Query: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239 IL+ + K+ L E +++ + P + L D LC + +Y G+L L Sbjct: 619 ILRPDA--TKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFL 676 Query: 240 SRERVFSEDRAR---------------------FYGAEIVSALDYLHSEKNVVYRDLKLE 278 S ++ ED+A A+I S + YL + N V+RDL Sbjct: 677 SAHQL--EDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLATR 733 Query: 279 NLMLDKDGHIKITDFGLCKE-GIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLG 336 N ++ ++ IKI DFG+ + D ++ P ++A E + + A D W G Sbjct: 734 NCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFG 793 Query: 337 VVMYE--MMCGRLPFYNQDHEKLFE 359 V ++E M+C PF E++ E Sbjct: 794 VTLWEVLMLCRAQPFGQLTDEQVIE 818 >4PL5-B nrPDB Length = 435 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 76/272 (27%), Positives = 115/272 (42%), Gaps = 33/272 (12%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG G G I+ K R A+K + E D L E+ N F T Sbjct: 34 VLGHGAEG-TIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKD 92 Query: 215 YSFQ-THDRLCF--VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 FQ LC + EY + F HL E + + S L +LHS N+V Sbjct: 93 RQFQYIAIELCAATLQEYVEQKD-FAHLGLEPIT-------LLHQTTSGLAHLHS-LNIV 143 Query: 272 YRDLKLENLML---DKDGHIK--ITDFGLCKE---GIKDGATMKTFCGTPEYLAPEVLED 323 +RDLK N++L + G IK I+DFGLCK+ G + GT ++APE+L + Sbjct: 144 HRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 203 Query: 324 ---NDYGRAVDWWGLGVVMYEMMC-GRLPF---YNQDHEKLFELILMEEIRFPRTLGPEA 376 ++ VD + G V Y ++ G PF + L ++ + A Sbjct: 204 DCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDCFHSDKHEDVIA 263 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + L+ ++ DP+QR AK +++H FF Sbjct: 264 RELIEKMIAMDPQQR-----PSAKHVLKHPFF 290 >5XVU-A nrPDB Length = 332 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 34/108 (31%), Positives = 59/108 (54%), Gaps = 4/108 (3%) Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG-HIKITDFGLCKEGIKDG 303 F++ R+Y +I+ ALDY HS+ +++RD+K N+M+D + I++ +GL E G Sbjct: 122 FTDKDIRYYIYQILKALDYCHSQ-GIMHRDVKPHNIMIDHENRQIRLISWGLA-EFYHPG 179 Query: 304 ATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFY 350 + Y PE+L D Y ++D W LG ++ M+ + PF+ Sbjct: 180 QEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFF 227 >5KMM-A nrPDB Length = 329 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 65/268 (24%), Positives = 110/268 (41%), Gaps = 44/268 (16%) Query: 156 LGKGTFGKVILVK-----EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 LG+G FGKV L + + A+K LK+ A+ + E +L +H + Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR---EAELLTMLQHQHI 99 Query: 211 TALKYSFQTHDR-LCFVMEYANGGELFFHLSRERVFSEDRARFYGAE------------- 256 + T R L V EY G+L L R D G E Sbjct: 100 VRF-FGVCTEGRPLLMVFEYMRHGDLNRFL---RSHGPDAKLLAGGEDVAPGPLGLGQLL 155 Query: 257 -----IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK------DGAT 305 + + + YL + + V+RDL N ++ + +KI DFG+ ++ G T Sbjct: 156 AVASQVAAGMVYL-AGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT 214 Query: 306 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM- 363 M ++ PE + + D W GVV++E+ G+ P+Y + + + I Sbjct: 215 MLPI----RWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQG 270 Query: 364 EEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 E+ PR PE +++ G +++P+QR Sbjct: 271 RELERPRACPPEVYAIMRGCWQREPQQR 298 >6O6Q-A nrPDB Length = 335 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 34/109 (31%), Positives = 59/109 (54%), Gaps = 4/109 (3%) Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDG 303 F++ RFY E++ ALDY HS +++RD+K N+M+D D +++ D+GL E G Sbjct: 132 FTDYDIRFYMYELLKALDYSHS-MGIMHRDVKPHNVMIDHDKKLLRLIDWGLA-EYYHPG 189 Query: 304 ATMKTFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYN 351 + + PE+L D Y ++D W G ++ M+ + PF++ Sbjct: 190 TEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFH 238 >3G2F-A nrPDB Length = 336 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 62/248 (25%), Positives = 103/248 (41%), Gaps = 59/248 (23%) Query: 134 MEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK----------- 182 ME + ++P + ++ + L+L+G+G +G V K R A+K+ Sbjct: 1 MEAAASEPS--LDLDNLKLLELIGRGRYGAVY--KGSLDERPVAVKVFSFANRQNFINEK 56 Query: 183 ---KEVIVAKDEVAHTLT-ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238 + ++ D +A + + RV + R +L VMEY G L + Sbjct: 57 NIYRVPLMEHDNIARFIVGDERVTADGRMEYL--------------LVMEYYPNGSLCKY 102 Query: 239 LSRERVFSEDRARFYGAEIVSALDYLHSE--------KNVVYRDLKLENLMLDKDGHIKI 290 LS R + L YLH+E + +RDL N+++ DG I Sbjct: 103 LSLHTSDWVSSCRL-AHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVI 161 Query: 291 TDFG---------LCKEGIKDGATMKTFCGTPEYLAPEVLE------DNDYG-RAVDWWG 334 +DFG L + G +D A + GT Y+APEVLE D + + VD + Sbjct: 162 SDFGLSMRLTGNRLVRPGEEDNAAISEV-GTIRYMAPEVLEGAVNLRDCESALKQVDMYA 220 Query: 335 LGVVMYEM 342 LG++ +E+ Sbjct: 221 LGLIYWEI 228 >3PG1-A nrPDB Length = 362 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 86/208 (41%), Gaps = 15/208 (7%) Query: 195 TLTENRVLQNSRHPFLTALKYSFQTHD-----RLCFVMEYANGGELFFHLSRERVFSEDR 249 L E R+L + HP + L+ F + +L V E + V S Sbjct: 76 VLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQH 135 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309 +++ I+ L LH E VV+RDL N++L + I I DF L +E D A + Sbjct: 136 IQYFMYHILLGLHVLH-EAGVVHRDLHPGNILLADNNDITICDFNLAREDTAD-ANKTHY 193 Query: 310 CGTPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEMMCGRL-----PFYNQDHEKLFELILM 363 Y APE V++ + + VD W G VM EM + FYNQ K+ E++ Sbjct: 194 VTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQ-LNKIVEVVGT 252 Query: 364 EEIRFPRTL-GPEAKSLLSGLLKKDPKQ 390 +I P A+ L L P + Sbjct: 253 PKIEDVVMFSSPSARDYLRNSLSNVPAR 280 >3MDY-A nrPDB Length = 337 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 54/223 (24%), Positives = 100/223 (44%), Gaps = 32/223 (14%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 R + + +K +GKG +G+V + G++ K+ K + E A E + Sbjct: 32 QRTIAKQIQMVKQIGKGRYGEVWM------GKWRGEKVAVK--VFFTTEEASWFRETEIY 83 Query: 203 QNS--RHP----FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 Q RH F+ A + +L + +Y G L+ +L + ++ + + Sbjct: 84 QTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSS 143 Query: 257 IVSALDYLHSE-------KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM--- 306 VS L +LH+E + +RDLK +N+++ K+G I D GL + I D + Sbjct: 144 -VSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 202 Query: 307 -KTFCGTPEYLAPEVLED----NDYGRAV--DWWGLGVVMYEM 342 T GT Y+ PEVL++ N + + D + G++++E+ Sbjct: 203 PNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEV 245 >3G0E-A nrPDB Length = 336 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 66/274 (24%), Positives = 111/274 (40%), Gaps = 34/274 (12%) Query: 148 NEFEYLKLLGKGTFGKVI------LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 N + K LG G FGKV+ L+K A A+K+LK + + E ++E +V Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDA-AMTVAVKMLKPSAHLTEREA--LMSELKV 102 Query: 202 LQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER---VFSEDRARF----- 252 L H + L + + EY G+L L R+R + S+ Sbjct: 103 LSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDE 162 Query: 253 ----------YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD 302 + ++ + +L S KN ++RDL N++L KI DFGL ++ D Sbjct: 163 LALDLEDLLSFSYQVAKGMAFLAS-KNCIHRDLAARNILLTHGRITKICDFGLARDIKND 221 Query: 303 GA-TMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFE 359 +K P +++APE + + Y D W G+ ++E+ G P+ + F Sbjct: 222 SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY 281 Query: 360 LILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQR 391 ++ E R P E ++ DP +R Sbjct: 282 KMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKR 315 >5M07-A nrPDB Length = 276 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 84/217 (38%), Gaps = 35/217 (16%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT-ENRVLQ 203 VT + +++LG G+V LV+ + A+K+L + A DE E V Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSP-AMAADDEFRRRFQRETEVAA 85 Query: 204 NSRHPFLTALKYSFQTHDR------LCFVMEYANGGELFFHLSRE--RVFSEDRARFYGA 255 HP + + HDR L M+Y +G + H++ V Sbjct: 86 RLFHPHI------LEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVT 139 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDK----DGHIKITDFGLCKEGIKDGATMKTFCG 311 + ALDY H ++ +++RD+ N++L D I + DFG+ + Sbjct: 140 AVAGALDYAH-QRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ------------- 185 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP 348 P Y APE+ D D + L + + G P Sbjct: 186 -PSYPAPELSAGADVDGRADQYALALTAIHLFAGAPP 221 >5XD6-A nrPDB Length = 305 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 88/208 (42%), Gaps = 18/208 (8%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 L+G+G++G+V K +G+ A+K L ++ +A +R+ Q + + L Sbjct: 29 LIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQEN---VVALLG 84 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRER---------VFSEDRARFYGAEIVSALDYLH 265 Y R+ EYA G L L + V S + L+YLH Sbjct: 85 YCVDGPLRV-LAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLH 143 Query: 266 SEKN--VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT--FCGTPEYLAPEVL 321 + N V++RD+K N++L D KI DF L + A + + GT Y APE Sbjct: 144 EKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYA 203 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 D + GVV+ E++ GR P Sbjct: 204 MTGTLSTKSDVYSFGVVLLELLTGRKPV 231 >4XUF-A nrPDB Length = 297 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 102/224 (45%), Gaps = 34/224 (15%) Query: 150 FEYLKLLGKGTFGKVIL-----VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-Q 203 E+ K+LG G FGKV+ + + A+K+LK++ ++ E ++E +++ Q Sbjct: 11 LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA--LMSELKMMTQ 68 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL-SRERVFSEDRARF---------- 252 H + L + + + EY G+L +L S+ FSED + Sbjct: 69 LGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 128 Query: 253 ------------YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300 + ++ +++L K+ V+RDL N+++ +KI DFGL ++ + Sbjct: 129 DLNVLTFEDLLCFAYQVAKGMEFLEF-KSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 187 Query: 301 KDGA-TMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 D ++ P +++APE L + Y D W G++++E+ Sbjct: 188 SDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEI 231 >3PLS-A nrPDB Length = 298 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 93/208 (44%), Gaps = 12/208 (5%) Query: 154 KLLGKGTFGKVI---LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 +++GKG FG V + + A+K L + I +V L E +++ HP + Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR--ITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 211 TALKYSFQTHDRLCFVM-EYANGGELF-FHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 AL + L V+ Y G+L F S +R + +G ++ ++YL +E+ Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYL-AEQ 143 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD---GATMKTFCGTP-EYLAPEVLEDN 324 V+RDL N MLD+ +K+ DFGL ++ + P ++ A E L+ Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQ 352 + D W GV+++E++ P Y Sbjct: 204 RFTTKSDVWSFGVLLWELLTRGAPPYRH 231 >5X02-A nrPDB Length = 347 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 102/224 (45%), Gaps = 34/224 (15%) Query: 150 FEYLKLLGKGTFGKVIL-----VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-Q 203 E+ K+LG G FGKV+ + + A+K+LK++ ++ E ++E +++ Q Sbjct: 50 LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA--LMSELKMMTQ 107 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL-SRERVFSEDRARF---------- 252 H + L + + + EY G+L +L S+ FSED + Sbjct: 108 LGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 167 Query: 253 ------------YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300 + ++ +++L K+ V+RDL N+++ +KI DFGL ++ + Sbjct: 168 DLNVLTFEDLLCFAYQVAKGMEFLEF-KSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 226 Query: 301 KDGA-TMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 D ++ P +++APE L + Y D W G++++E+ Sbjct: 227 SDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEI 270 >3RP9-A nrPDB Length = 458 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 62/281 (22%), Positives = 118/281 (41%), Gaps = 46/281 (16%) Query: 97 EEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTM-NEFEYLKL 155 ++ + Q G +++ ++ S P+ S+ +P + + +E L Sbjct: 10 QQHNSGTQHTVSGSQQEGQQRKQHHSSKPT---------ASMPRPHSDWQIPDRYEIRHL 60 Query: 156 LGKGTFGKVILVKEKATGRYYAMK-ILK--KEVIVAKDEVAHTLTENRVLQNSRHPFL-T 211 +G G++G V +K R A+K IL+ +++I K + NR+ + L Sbjct: 61 IGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDI 120 Query: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF-SEDRARFYGAEIVSALDYLHSEKNV 270 + + D L V+E A+ F L R V+ +E + ++ + Y+HS + Sbjct: 121 VIPKDVEKFDELYVVLEIADSD--FKKLFRTPVYLTELHIKTLLYNLLVGVKYVHS-AGI 177 Query: 271 VYRDLKLENLMLDKDGHIKITDFGLCK--------------EGIKDGATMKTFCGTPE-- 314 ++RDLK N ++++D +K+ DFGL + +D + TF T Sbjct: 178 LHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLK 237 Query: 315 -----------YLAPE-VLEDNDYGRAVDWWGLGVVMYEMM 343 Y APE +L +Y A+D W +G + E++ Sbjct: 238 RQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 >5TE0-A nrPDB Length = 347 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 58/238 (24%), Positives = 110/238 (46%), Gaps = 48/238 (20%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEK-----ATGRYYA-----MKILKKEVIVAKDE 191 + +VT++E +L +G F V LV+ A R + +++ K+E+ + +D Sbjct: 18 RQQVTVDE-----VLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDL 72 Query: 192 VAHTLTENRVLQNSRHPFLTALKYSFQTHD--RLCFVMEYANGGELFFHLSRERV---FS 246 H +N V ++ + + + D + +M++ GG++ +L +R+ F+ Sbjct: 73 SGH---KNIV------GYIDSSINNVSSGDVWEVLILMDFCRGGQVV-NLMNQRLQTGFT 122 Query: 247 EDRARFYGAEIVSALDYLHSEKN-VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT 305 E+ + A+ LH K +++RDLK+EN++L GH + DFG ++ T Sbjct: 123 ENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQT 182 Query: 306 ---------MKTFCGTPEYLAPEVLEDNDYGRAV-----DWWGLGVVMYEMMCGRLPF 349 +K + T Y APE++ N Y + D W LG ++Y++ LPF Sbjct: 183 EGVNAVEDEIKKY-TTLSYRAPEMV--NLYSGKIITTKADIWALGCLLYKLCYFTLPF 237 >4F9B-A nrPDB Length = 361 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 69/280 (24%), Positives = 105/280 (37%), Gaps = 44/280 (15%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAM---KILKKEVIVAKDEVAHTLTENRVLQN 204 N F+ +G+GTF V L AT + KI K +I + + Sbjct: 21 NVFKIEDKIGEGTFSSVYL----ATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVA 76 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 + +KY F+ +D + M Y E F + F E R Y + AL + Sbjct: 77 GGQDNVMGVKYCFRKNDHVVIAMPYLEH-ESFLDILNSLSFQE--VREYMLNLFKALKRI 133 Query: 265 HSEKNVVYRDLKLENLMLDKD-GHIKITDFGL---------------------------- 295 H + +V+RD+K N + ++ + DFGL Sbjct: 134 H-QFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNK 192 Query: 296 CKEGIKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354 C + + GTP + APEVL + A+D W GV+ ++ GR PFY Sbjct: 193 CSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKAS- 251 Query: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLL--KKDPKQRL 392 + L L + IR R AK+ +L K+ P Q L Sbjct: 252 DDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDL 291 >5E8V-A nrPDB Length = 316 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 97/226 (42%), Gaps = 31/226 (13%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKA-TGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 H + E L+GKG F +V K K T + +K I +E A TE + Sbjct: 4 HNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVK---IFPYEEYASWKTEKDI 60 Query: 202 LQ--NSRH----PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 N +H FLTA + + + + + G L +L+R + ED R G+ Sbjct: 61 FSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWED-LRKLGS 119 Query: 256 EIVSALDYLHSEKN--------VVYRDLKLENLMLDKDGHIKITDFGLCKE-----GIKD 302 + + +LHS+ +V+RDLK N+++ D + DFGL + D Sbjct: 120 SLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDD 179 Query: 303 GATMKTFCGTPEYLAPEV------LEDNDYGRAVDWWGLGVVMYEM 342 A GT Y+APEV LE+ + + D + + +V++EM Sbjct: 180 LANSGQV-GTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEM 224 >6HV0-A nrPDB Length = 416 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/171 (29%), Positives = 83/171 (48%), Gaps = 27/171 (15%) Query: 256 EIVSALDYLHSEKNVVYRDLKLENLML---DKDGHIK--ITDFGLCKE---GIKDGATMK 307 + S L +LHS N+V+RDLK N+++ + G IK I+DFGLCK+ G + Sbjct: 110 QTTSGLAHLHS-LNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRS 168 Query: 308 TFCGTPEYLAPEVLEDN---DYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM 363 GT ++APE+L ++ + VD + G V Y ++ G PF + L+ Sbjct: 169 GVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGA 228 Query: 364 EEIRFPRTLGPE------AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + L PE A+ L+ ++ DP++R AK +++H FF Sbjct: 229 CSL---DCLHPEKHEDVIARELIEKMIAMDPQKR-----PSAKHVLKHPFF 271 >4C59-A nrPDB Length = 340 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 65/270 (24%), Positives = 112/270 (41%), Gaps = 40/270 (14%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN--SRHP--- 208 ++L +G F V ++ +GR YA+K L + ++E + + S HP Sbjct: 33 RVLAEGGFAFVYEAQDVGSGREYALKRL----LSNEEEKNRAIIQEVCFMKKLSGHPNIV 88 Query: 209 -FLTALKYSFQTHD----RLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSAL 261 F +A + D + E G E + S D + A+ Sbjct: 89 QFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAV 148 Query: 262 DYLHSEKN-VVYRDLKLENLMLDKDGHIKITDFGLC---------------KEGIKDGAT 305 ++H +K +++RDLK+ENL+L G IK+ DFG + +++ T Sbjct: 149 QHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEIT 208 Query: 306 MKTFCGTPEYLAPEVLE---DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 362 T TP Y PE+++ + G D W LG ++Y + + PF +D KL + Sbjct: 209 RNT---TPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF--EDGAKLRIVNG 263 Query: 363 MEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 I T SL+ +L+ +P++RL Sbjct: 264 KYSIPPHDTQYTVFHSLIRAMLQVNPEERL 293 >3AOX-A nrPDB Length = 344 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 51/244 (20%), Positives = 104/244 (42%), Gaps = 36/244 (14%) Query: 141 PKHRVTMNEFEYLKLLGKGTFG-----KVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 P+ +T+ ++ LG G FG +V + + A+K L EV +DE+ Sbjct: 45 PRKNITL-----IRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCSEQDELDFL 98 Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 + + + + + + S Q+ R ++E GG+L + E R R Sbjct: 99 MEALIISKFNHQNIVRCIGVSLQSLPRF-ILLELMAGGDL------KSFLRETRPRPSQP 151 Query: 256 EIVSALDYLHSEKNV------------VYRDLKLENLMLDKDGH---IKITDFGLCKEGI 300 ++ LD LH +++ ++RD+ N +L G KI DFG+ ++ Sbjct: 152 SSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIY 211 Query: 301 KDGATMKTFCGT--PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKL 357 + K C +++ PE + + D W GV+++E+ G +P+ ++ ++++ Sbjct: 212 RASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEV 271 Query: 358 FELI 361 E + Sbjct: 272 LEFV 275 >2CMW-A nrPDB Length = 310 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 90/210 (42%), Gaps = 20/210 (9%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 K +G G FG++ L K T Y A+K+ E I ++ H S L + Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIKL---EPIKSRAPQLHLEYRFYKQLGSAGEGLPQV 62 Query: 214 KYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272 Y V+E E F L +R F+ +++S ++Y+HS KN++Y Sbjct: 63 YYFGPCGKYNAMVLELLGPSLEDLFDLC-DRTFTLKTVLMIAIQLLSRMEYVHS-KNLIY 120 Query: 273 RDLKLENLMLDKDGH-----IKITDFGLCKEGIKDGAT--------MKTFCGTPEYLAPE 319 RD+K EN ++ + G+ I I DFGL KE I D T K+ GT Y++ Sbjct: 121 RDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYI-DPETKKHIPYREHKSLTGTARYMSIN 179 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 + R D LG + + G LP+ Sbjct: 180 THLGKEQSRRDDLEALGHMFMYFLRGSLPW 209 >3PP0-A nrPDB Length = 338 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 93/209 (44%), Gaps = 23/209 (11%) Query: 148 NEFEYLKLLGKGTFGKV---ILVKEKATGRY-YAMKILKKEVIVAKDEVAHTLTENRVLQ 203 E +K+LG G FG V I + + + A+K+L++ ++ L E V+ Sbjct: 17 TELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANK--EILDEAYVMA 74 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL--SRERVFSEDRARFYGAEIVSAL 261 P+++ L + V + G L H+ +R R+ S+D + +I + Sbjct: 75 GVGSPYVSRL-LGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLN-WCMQIAKGM 132 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK-------EGIKDGATMKTFCGTPE 314 YL + +V+RDL N+++ H+KITDFGL + E DG + + Sbjct: 133 SYLEDVR-LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPI-----K 186 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343 ++A E + + D W GV ++E+M Sbjct: 187 WMALESILRRRFTHQSDVWSYGVTVWELM 215 >2CHL-A nrPDB Length = 351 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 28/238 (11%) Query: 126 SDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 185 ++N + M V + P RV K +G G FG++ L K T Y A+K+ E Sbjct: 15 TENLYFQSMGVLMVGPNFRVG-------KKIGCGNFGELRLGKNLYTNEYVAIKL---EP 64 Query: 186 IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERV 244 + ++ H L Q + + Y V+E E F L +R Sbjct: 65 MKSRAPQLH-LEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLC-DRT 122 Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-----IKITDFGLCKEG 299 FS +++S ++Y+HS KN++YRD+K EN ++ + G+ I I DF L KE Sbjct: 123 FSLKTVLMIAIQLISRMEYVHS-KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 Query: 300 IKDGAT--------MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 I D T K+ GT Y++ + R D LG + + G LP+ Sbjct: 182 I-DPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 238 >3VHK-A nrPDB Length = 368 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 41/144 (28%), Positives = 68/144 (47%), Gaps = 6/144 (4%) Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD-GATMKTFCG 311 Y ++ +++L S K ++RDL N++L + +KI DFGL ++ KD K Sbjct: 205 YSFQVAKGMEFLASRK-CIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR 263 Query: 312 TP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME--EIR 367 P +++APE + D Y D W GV+++E+ G P+ ++ F L E +R Sbjct: 264 LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMR 323 Query: 368 FPRTLGPEAKSLLSGLLKKDPKQR 391 P PE + +P QR Sbjct: 324 APDYTTPEMYQTMLDCWHGEPSQR 347 >4M66-A nrPDB Length = 325 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 95/215 (44%), Gaps = 21/215 (9%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 V+ E + L+ +GKG FG V + A+KI+ + I + + L VL Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVL-- 74 Query: 205 SRHPFLTA----LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 L L++ F + L V + G L L E E+V Sbjct: 75 ----LLLGVTEDLQWDFVSGQAL--VTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLG 128 Query: 261 LDYLHS-EKNVVYRDLKLENLMLDKDGHIKITDFGLC------KEGIKDGATMKTFCGTP 313 + YLHS + +++RDLK N++LD + H K+ DFGL + G G+ + GT Sbjct: 129 MCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTL 188 Query: 314 EYLAPEVLEDNDY--GRAVDWWGLGVVMYEMMCGR 346 YL PE+L + +A D + G++++ ++ GR Sbjct: 189 AYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >3I81-A nrPDB Length = 315 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 114/259 (44%), Gaps = 34/259 (13%) Query: 124 SPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVI------LVKEKATGRYYA 177 S +D +E EV+ + ++TM+ + LG+G+FG V +VK++ R A Sbjct: 3 SAADVYVPDEWEVA----REKITMS-----RELGQGSFGMVYEGVAKGVVKDEPETRV-A 52 Query: 178 MKILKKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELF 236 +K + + + E L E V++ + H + L Q L +ME G+L Sbjct: 53 IKTVNEAA--SMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV-IMELMTRGDLK 109 Query: 237 FHLSRERVFSEDRARF----------YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286 +L R E+ EI + YL++ K V+RDL N M+ +D Sbjct: 110 SYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANK-FVHRDLAARNCMVAEDF 168 Query: 287 HIKITDFGLCKEGIKDGATMKTFCGT--PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC 344 +KI DFG+ ++ + K G +++PE L+D + D W GVV++E+ Sbjct: 169 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIAT 228 Query: 345 -GRLPFYNQDHEKLFELIL 362 P+ +E++ ++ Sbjct: 229 LAEQPYQGLSNEQVLRFVM 247 >4IAN-A nrPDB Length = 358 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 48/223 (21%), Positives = 98/223 (43%), Gaps = 11/223 (4%) Query: 157 GKGTFGKVILVKEKA-TGRYYAMKILKKEVIVAK---DEVAHTLTENRVLQNSRHPFLTA 212 G+G F V+ ++ A + A+KI++ ++ K E+ N + + L Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRL 98 Query: 213 LKYSFQTHDRLCFVME--YANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNV 270 ++ F LC V E N E+ ++ R Y ++ AL L N+ Sbjct: 99 FRH-FYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLL-KRCNI 156 Query: 271 VYRDLKLENLMLDKDGHI-KITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 ++ D+K +N+++++ I K+ DFG + T + + Y APE++ Y Sbjct: 157 LHADIKPDNILVNESKTILKLCDFGSASHVADNDIT--PYLVSRFYRAPEIIIGKSYDYG 214 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL 372 +D W +G +YE+ G++ F + + + +L + + + P + Sbjct: 215 IDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKM 257 >5GNK-A nrPDB Length = 297 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 91/208 (43%), Gaps = 8/208 (3%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH--TLTENRVLQNS 205 EF+ +K+LG G FG V G + + KE+ A A+ L E V+ + Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYL 264 +P + L + +M+ G L ++ + + +I ++YL Sbjct: 79 DNPHVCRL-LGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYL 137 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK-EGIKDGATMKTFCGTP-EYLAPEVLE 322 ++ +V+RDL N+++ H+KITDFGL K G ++ P +++A E + Sbjct: 138 E-DRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 196 Query: 323 DNDYGRAVDWWGLGVVMYEMMC-GRLPF 349 Y D W GV ++E+M G P+ Sbjct: 197 HRIYTHQSDVWSYGVTVWELMTFGSKPY 224 >3ZBF-A nrPDB Length = 322 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 64/280 (22%), Positives = 115/280 (41%), Gaps = 40/280 (14%) Query: 139 AKPKHRVTMNEFEYLKLLGKGTFGKV-----ILVKEKATGRY-YAMKILKKEVIVAKDEV 192 A P+ ++T+ LLG G FG+V + + +G A+K LKK E Sbjct: 29 AFPREKLTLR-----LLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGS--TDQEK 81 Query: 193 AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF 252 L E ++ HP + ++ ++E GG+L +L + R+ A F Sbjct: 82 IEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARM-----ATF 136 Query: 253 YG------------AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-----IKITDFGL 295 YG +I YL + ++RDL N ++ + +KI DFGL Sbjct: 137 YGPLLTLVDLVDLCVDISKGCVYLE-RMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGL 195 Query: 296 CKEGIKDGATMKTFCGT--PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM-CGRLPFYNQ 352 ++ K+ K G ++APE L D + D W G++++E++ G P+ Sbjct: 196 ARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAH 255 Query: 353 DHEKLFELILM-EEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 + + + + PR + +L++ ++P QR Sbjct: 256 SNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQR 295 >4CRL-A nrPDB Length = 406 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 59/245 (24%), Positives = 112/245 (45%), Gaps = 28/245 (11%) Query: 127 DNSGAEEMEVSLAKPKHRV-TMNEFEYLKLLGKGTFGKV--ILVKEKATGRYYAMKILKK 183 D+ + +V L+ + RV + E+E K+ G+GT+G V K+ + YA+K ++ Sbjct: 1 DDKMDYDFKVKLSSERERVEDLFEYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEG 59 Query: 184 EVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTH-DRLCFVMEYANGGELFFHLSRE 242 I E +L+ +HP + +L+ F +H DR +++ +L+ + Sbjct: 60 TGISMS-----ACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFH 114 Query: 243 RVFSEDR---------ARFYGAEIVSALDYLHSEKNVVYRDLKLENLML----DKDGHIK 289 R ++ + +I+ + YLH+ V++RDLK N+++ + G +K Sbjct: 115 RASKANKKPVQLPRGMVKSLLYQILDGIHYLHANW-VLHRDLKPANILVMGEGPERGRVK 173 Query: 290 ITDFGLCK---EGIKDGATMKTFCGTPEYLAPEVL-EDNDYGRAVDWWGLGVVMYEMMCG 345 I D G + +K A + T Y APE+L Y +A+D W +G + E++ Sbjct: 174 IADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTS 233 Query: 346 RLPFY 350 F+ Sbjct: 234 EPIFH 238 >3NIE-A nrPDB Length = 429 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/251 (22%), Positives = 104/251 (41%), Gaps = 42/251 (16%) Query: 128 NSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK---E 184 +SG E + A K+ + +E L+G+G++G V L +K + A+K + + + Sbjct: 8 SSGRENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFED 67 Query: 185 VIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF-----VMEYANGGELFFHL 239 +I K L E +L + ++ L D L F V+E A+ L Sbjct: 68 LIDCK----RILREITILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSD--LKKL 121 Query: 240 SRERVF-SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298 + +F +E + ++ ++H E +++RDLK N +L++D +KI DFGL + Sbjct: 122 FKTPIFLTEQHVKTILYNLLLGEKFIH-ESGIIHRDLKPANCLLNQDCSVKICDFGLART 180 Query: 299 GIKD-------------------------GATMKTFCGTPEYLAPE-VLEDNDYGRAVDW 332 D + + T Y APE +L +Y ++D Sbjct: 181 INSDKDIHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDI 240 Query: 333 WGLGVVMYEMM 343 W G + E++ Sbjct: 241 WSTGCIFAELL 251 >3N9X-A nrPDB Length = 432 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/221 (23%), Positives = 98/221 (44%), Gaps = 39/221 (17%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKK---EVIVAKDEVAHTLTENRVLQNSRHPFLT 211 L+G+G++G V L +K T + A+K + + ++I K L E +L + ++ Sbjct: 33 LIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCK----RILREITILNRLKSDYII 88 Query: 212 ALKYSFQTHDRLCF-----VMEYANGGELFFHLSRERVF-SEDRARFYGAEIVSALDYLH 265 L D L F V+E A+ L + +F +E+ + ++ +++H Sbjct: 89 RLYDLIIPDDLLKFDELYIVLEIADSD--LKKLFKTPIFLTEEHIKTILYNLLLGENFIH 146 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT-------------------- 305 E +++RDLK N +L++D +K+ DFGL + + T Sbjct: 147 -ESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLK 205 Query: 306 --MKTFCGTPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEMM 343 + + T Y APE +L +Y +++D W G + E++ Sbjct: 206 KQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >5C01-A nrPDB Length = 342 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 74/282 (26%), Positives = 115/282 (40%), Gaps = 40/282 (14%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVI--LVKEKATGRYYAMKILKKEVIV-AKDEVAHTLTEN 199 HRV E L LG+GT V ++ + +G K+ ++ +V +D Sbjct: 53 HRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVL 112 Query: 200 RVLQNSRHP-----FLTALKYSFQTHDRLCF-------------VMEYANGGELFFHLSR 241 +VL S H + TA S +H L F V EY G L L R Sbjct: 113 KVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRR 172 Query: 242 ERVFSEDRARFYGA-EIVSALDYLHSEKNVVYRDLKLENLMLDKDG-------HIKITDF 293 ER + A ++ SAL YL + KN+V+ ++ N++L + G IK++D Sbjct: 173 ERGHVPMAWKMVVAQQLASALSYLEN-KNLVHGNVCGRNILLARLGLAEGTSPFIKLSDP 231 Query: 294 GLCKEGIKDGATMKTFCGTPEYLAPEVLED--NDYGRAVDWWGLGVVMYEMMC--GRLPF 349 G+ + ++ +LAPE L N A+D WG G + E +C G P Sbjct: 232 GVGLGALSREERVERI----PWLAPECLPGGANSLSTAMDKWGFGATLLE-ICFDGEAPL 286 Query: 350 YNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 ++ + E + R P P+ +L S L +P QR Sbjct: 287 QSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR 327 >3LZB-A nrPDB Length = 327 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 87/207 (42%), Gaps = 6/207 (2%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH--TLTENRVLQNS 205 EF+ +K+LG G FG V G + + KE+ A A+ L E V+ + Sbjct: 15 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 74 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 +P + L T G L + + + +I ++YL Sbjct: 75 DNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLE 134 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCK-EGIKDGATMKTFCGTP-EYLAPEVLED 323 ++ +V+RDL N+++ H+KITDFGL K G ++ P +++A E + Sbjct: 135 -DRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILH 193 Query: 324 NDYGRAVDWWGLGVVMYEMMC-GRLPF 349 Y D W GV ++E+M G P+ Sbjct: 194 RIYTHQSDVWSYGVTVWELMTFGSKPY 220 >4WOV-A nrPDB Length = 317 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 76/283 (26%), Positives = 116/283 (40%), Gaps = 42/283 (14%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVI--LVKEKATGRYYAMKILKKEVIV-AKDEVAHTLTEN 199 HRV E L LG+GT V ++ + +G K+ ++ +V +D Sbjct: 30 HRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVL 89 Query: 200 RVLQNSRHP-----FLTALKYSFQTHDRLCF-------------VMEYANGGELFFHLSR 241 +VL S H + TA S +H L F V EY G L L R Sbjct: 90 KVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRR 149 Query: 242 ERVFSEDRARFYGA-EIVSALDYLHSEKNVVYRDLKLENLMLDKDG-------HIKITDF 293 ER + A ++ SAL YL + KN+V+ ++ N++L + G IK++D Sbjct: 150 ERGHVPMAWKMVVAQQLASALSYLEN-KNLVHGNVCGRNILLARLGLAEGTSPFIKLSDP 208 Query: 294 GLCKEGIKDGATMKTFCGTPEYLAPEVLED--NDYGRAVDWWGLGVVMYEMMC--GRLPF 349 G+ + ++ +LAPE L N A+D WG G + E +C G P Sbjct: 209 GVGLGALSREERVERI----PWLAPECLPGGANSLSTAMDKWGFGATLLE-ICFDGEAPL 263 Query: 350 YNQD-HEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 ++ EK E + R P P+ +L S L +P QR Sbjct: 264 QSRSPSEK--EHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR 304 >4TN6-A nrPDB Length = 318 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 96/216 (44%), Gaps = 23/216 (10%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 N + + +G G+FG + L + A G A+K+ E + K H E+++ + + Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL---ECVKTKHPQLH--IESKIYKMMQG 61 Query: 208 PF-LTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 + +++ D VME +LF SR+ FS +++S ++Y+ Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRK--FSLKTVLLLADQMISRIEYI 119 Query: 265 HSEKNVVYRDLKLENLM--LDKDGH-IKITDFGLCKEGIKDGATM--------KTFCGTP 313 HS KN ++RD+K +N + L K G+ + I DFGL K+ +D T K GT Sbjct: 120 HS-KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKK-YRDARTHQHIPYRENKNLTGTA 177 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 Y + + R D LG V+ G LP+ Sbjct: 178 RYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPW 213 >2JD5-A nrPDB Length = 373 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 53/233 (22%), Positives = 96/233 (41%), Gaps = 32/233 (13%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVI---VAKDEV--------AHTLTENRVLQN 204 LG G F V L K+ + AMKI++ + + A+DE+ A E+ + N Sbjct: 27 LGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGAN 86 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE---RVFSEDRARFYGAEIVSAL 261 H ++ + + + VM + GE L ++ R + +++ L Sbjct: 87 --HILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGL 144 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDG------HIKITDFGLCKEGIKDGATMKTFCGTPEY 315 DY+H +++ D+K EN++++ IKI D G T EY Sbjct: 145 DYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLG---NACWYDEHYTNSIQTREY 201 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF-------YNQDHEKLFELI 361 +PEVL +G D W +++E++ G F Y +D + + ++I Sbjct: 202 RSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQII 254 >3REP-A nrPDB Length = 271 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 40/192 (20%), Positives = 86/192 (44%), Gaps = 15/192 (7%) Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELF--FHLSRERVFSEDRARFYGAEIVSALDYLH 265 P L A + H L + + G L+ H V + +A + ++ + +LH Sbjct: 71 PVLGACQSPPAPHPTL--ITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLH 128 Query: 266 SEKNVVYRD-LKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 + + ++ R L ++M+D+D +I+ K + M P ++APE L+ Sbjct: 129 TLEPLIPRHALNSRSVMIDEDMTARIS-MADVKFSFQSPGRMYA----PAWVAPEALQKK 183 Query: 323 -DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIR--FPRTLGPEAKSL 379 ++ R+ D W V+++E++ +PF + + ++ + +E +R P + P L Sbjct: 184 PEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKL 243 Query: 380 LSGLLKKDPKQR 391 + + +DP +R Sbjct: 244 MKICMNEDPAKR 255 >6EQI-C nrPDB Length = 433 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 42/164 (25%), Positives = 77/164 (46%), Gaps = 22/164 (13%) Query: 269 NVVYRDLKLENLMLD---KDGH--IKITDFGLCKEGIKDGATM------KTFCGTPEYLA 317 N+ +RDLK +N+++D D + I ITDFG C ++G + + G +A Sbjct: 187 NISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMA 246 Query: 318 PEVLEDN-------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI-RFP 369 PE+ +Y ++ D W +G + YE+ PFY++ + L + E++ P Sbjct: 247 PEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPELP 305 Query: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413 T+ ++L+S +L + +RL + A + Q +A W Sbjct: 306 DTIPFIIRNLVSNMLSRSTNKRL--DCDVAATVAQLYLWAPSSW 347 >2C47-A nrPDB Length = 313 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 92/214 (42%), Gaps = 21/214 (9%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F K +G G FG++ L K T Y A+K+ E I ++ H L Q S Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKL---EPIKSRAPQLH-LEYRFYKQLSATEG 61 Query: 210 LTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 + + Y V+E E F L +R F+ ++++ ++Y+H+ K Sbjct: 62 VPQVYYFGPCGKYNAMVLELLGPSLEDLFDLC-DRTFTLKTVLMIAIQLITRMEYVHT-K 119 Query: 269 NVVYRDLKLENLMLDKDG-----HIKITDFGLCKEGIKDGAT--------MKTFCGTPEY 315 +++YRD+K EN ++ + G I I DFGL KE I D T K+ GT Y Sbjct: 120 SLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYI-DPETKKHIPYREHKSLTGTARY 178 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 ++ + R D LG + + G LP+ Sbjct: 179 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPW 212 >4LRM-A nrPDB Length = 334 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 87/210 (41%), Gaps = 9/210 (4%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH--TLTENRVLQ-- 203 EF+ +K+LG G FG V G + + KE+ A A+ L E V+ Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 204 -NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 N +P + L T G L + + + +I ++ Sbjct: 79 DNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMN 138 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK-EGIKDGATMKTFCGTP-EYLAPEV 320 YL ++ +V+RDL N+++ H+KITDFGL K G ++ P +++A E Sbjct: 139 YLE-DRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 197 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPF 349 + Y D W GV ++E+M G P+ Sbjct: 198 ILHRIYTHQSDVWSYGVTVWELMTFGSKPY 227 >2PZI-A nrPDB Length = 681 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 35/97 (36%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 225 FVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 VMEY G L S+ + A Y EI+ AL YLHS +VY DLK EN+ML + Sbjct: 161 IVMEYVGGQSL--KRSKGQKLPVAEAIAYLLEILPALSYLHS-IGLVYNDLKPENIMLTE 217 Query: 285 DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 + +K+ D G + + GTP + APE++ Sbjct: 218 E-QLKLIDLG----AVSRINSFGYLYGTPGFQAPEIV 249 >3LMG-A nrPDB Length = 344 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 50/216 (23%), Positives = 82/216 (37%), Gaps = 37/216 (17%) Query: 148 NEFEYLKLLGKGTFGKV-----------------ILVKEKATGRYYAMKILKKEVIVAKD 190 E LK+LG G FG V I V E +GR + + + Sbjct: 31 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL 90 Query: 191 EVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDR 249 + AH + R+L L V +Y G L H+ + R Sbjct: 91 DHAHIV---RLL-------------GLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQL 134 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK-EGIKDGATMKT 308 +G +I + YL E +V+R+L N++L +++ DFG+ D + + Sbjct: 135 LLNWGVQIAKGMYYL-EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYS 193 Query: 309 FCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343 TP +++A E + Y D W GV ++E+M Sbjct: 194 EAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELM 229 >6BFN-A nrPDB Length = 342 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 92/218 (42%), Gaps = 18/218 (8%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVL 202 R T N E LK+ G+G FG V + T YA+K LK+ + V + LTE L Sbjct: 19 RGTHNFSEELKI-GEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQL 75 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV---- 258 RHP + + C V + G L L + + +I+ Sbjct: 76 SRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTA 135 Query: 259 SALDYLHSEK-NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG---------ATMKT 308 A+ +LH + ++++ D+K N++LD+ K+ DFGL + G A +T Sbjct: 136 RAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQT 195 Query: 309 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346 GT YL E ++ D + GVV+ E + G+ Sbjct: 196 VRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >4Y12-A nrPDB Length = 375 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 35/97 (36%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 225 FVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 VMEY G L S+ + A Y EI+ AL YLHS +VY DLK EN+ML + Sbjct: 200 IVMEYVGGQSL--KRSKGQKLPVAEAIAYLLEILPALSYLHS-IGLVYNDLKPENIMLTE 256 Query: 285 DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 + +K+ D G + + GTP + APE++ Sbjct: 257 E-QLKLIDLG----AVSRINSFGYLYGTPGFQAPEIV 288 >3ZZW-A nrPDB Length = 289 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 31/112 (27%), Positives = 57/112 (50%), Gaps = 8/112 (7%) Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP- 313 A+I + ++YL S +VV++DL N+++ ++KI+D GL +E A G Sbjct: 135 AQIAAGMEYL-SSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVY--AADYYKLLGNSL 191 Query: 314 ---EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 ++APE + + D W GVV++E+ G P+ ++ + E+I Sbjct: 192 LPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMI 243 >2QLU-A nrPDB Length = 314 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 94/222 (42%), Gaps = 32/222 (14%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL---KKEVIVAKDEVAHT--LTEN 199 V + L++ +G FG V K + + A+KI K+ ++ E+ T + Sbjct: 12 VPRGSLQLLEIKARGRFGCVW--KAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHE 69 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 +LQ F+ A K L + + + G L +L + + + + + Sbjct: 70 NLLQ-----FIAAEKRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSR 123 Query: 260 ALDYLHSE----------KNVVYRDLKLENLMLDKDGHIKITDFGLC---KEGIKDGATM 306 L YLH + ++ +RD K +N++L D + DFGL + G G T Sbjct: 124 GLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTH 183 Query: 307 KTFCGTPEYLAPEVLE-----DNDYGRAVDWWGLGVVMYEMM 343 GT Y+APEVLE D +D + +G+V++E++ Sbjct: 184 GQV-GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELV 224 >4M69-B nrPDB Length = 283 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 41/177 (23%), Positives = 79/177 (44%), Gaps = 13/177 (7%) Query: 225 FVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 VMEY G L L RE+ + L LH + + +R++ + ++ Sbjct: 89 IVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETL-HRNISSSSFLVAG 147 Query: 285 DGHIKITDFGLCKEGIKDGATMKTF----CGTPEYLAPEVLED--NDYGRAVDWWGLGVV 338 +K+ F L K T K+ + Y++PE L++ Y + + G+V Sbjct: 148 GYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIV 207 Query: 339 MYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK----DPKQR 391 ++E+ G++PF D +K+ EL+ ++ + P +G + LL ++ + +P QR Sbjct: 208 LWEIATGKIPFEGCDSKKIRELVAEDKKQEP--VGQDCPELLREIINECRAHEPSQR 262 >3SV0-A nrPDB Length = 483 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 55/234 (23%), Positives = 100/234 (42%), Gaps = 32/234 (13%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI----LKKEVIVAKDEVAHTLTENRVLQ 203 N+F + +G G+FG++ L T A+K+ K ++ + ++ L + Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTGIP 66 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 N R F Y+ D L +E +LF SR+ S ++++ +++ Sbjct: 67 NVRW-FGVEGDYNVLVMDLLGPSLE-----DLFNFCSRK--LSLKTVLMLADQMINRVEF 118 Query: 264 LHSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATM--------KTFCGT 312 +HS K+ ++RD+K +N ++ + + I DFGL K+ +D +T K GT Sbjct: 119 VHS-KSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKK-YRDTSTHQHIPYRENKNLTGT 176 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN-------QDHEKLFE 359 Y + + R D LG V+ + G LP+ Q +EK+ E Sbjct: 177 ARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISE 230 >4JRN-A nrPDB Length = 372 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 15/129 (11%) Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE---VLEDN 324 + +V+ D+K N +L KDG + + DFG + G + GTP Y PE Sbjct: 221 QGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNSVGRAI----GTPGYEPPERPFQATGI 276 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE-AKSLLSGL 383 Y D W LG+ +Y + C P + +++ + + P T PE + L+ L Sbjct: 277 TYTFPTDAWQLGITLYCIWCKERP---TPADGIWDYLHFADC--PST--PELVQDLIRSL 329 Query: 384 LKKDPKQRL 392 L +DP++R+ Sbjct: 330 LNRDPQKRM 338 >4BTK-A nrPDB Length = 337 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 61/274 (22%), Positives = 111/274 (40%), Gaps = 56/274 (20%) Query: 100 TTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKG 159 + A+Q +A LK +E M + G E+ ++ P + V + ++ LK +G G Sbjct: 22 SNAMQCLAAALK--DETNM---------SGGGEQADIL---PANYVVKDRWKVLKKIGGG 67 Query: 160 TFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQT 219 FG++ Y AM +L +E + K E A +VL+ A+ Q Sbjct: 68 GFGEI----------YEAMDLLTRENVALKVESAQQ--PKQVLKME-----VAVLKKLQG 110 Query: 220 HDRLC-------------FVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYLH 265 D +C VM+ S+ R F+ G +I+ +++ +H Sbjct: 111 KDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIH 170 Query: 266 SEKNVVYRDLKLENLMLDK----DGHIKITDFGLCKE------GIKDGATMKTFCGTPEY 315 S ++RD+K N + + + DFGL ++ ++ + F GT Y Sbjct: 171 S-VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 229 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 + ++ + GR D W L ++ E G+LP+ Sbjct: 230 ASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW 263 >6BBQ-A nrPDB Length = 520 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 29/119 (24%) Query: 8 KEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRE-APLNNFSVAQCQLMKTE 66 +EGWL K G +KTW+ R+F+L ++ + Y E D + R PL N S+ + E Sbjct: 215 REGWLLKLGGRVKTWKRRWFILTDNCLY--YFEYTTDKEPRGIIPLENLSIRE-----VE 267 Query: 67 RPR-PNTFII-------------------RCLQWTTVIERTFHVETPEEREEWTTAIQT 105 PR PN F + R ++ V+ R +PEE+EEW +I+ Sbjct: 268 DPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYR-ISAPSPEEKEEWMKSIKA 325 >4BTF-A nrPDB Length = 469 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 41/177 (23%), Positives = 79/177 (44%), Gaps = 13/177 (7%) Query: 225 FVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 VMEY G L L RE+ + L LH + + +R++ + ++ Sbjct: 275 IVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETL-HRNISSSSFLVAG 333 Query: 285 DGHIKITDFGLCKEGIKDGATMKTF----CGTPEYLAPEVLED--NDYGRAVDWWGLGVV 338 +K+ F L K T K+ + Y++PE L++ Y + + G+V Sbjct: 334 GYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIV 393 Query: 339 MYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK----DPKQR 391 ++E+ G++PF D +K+ EL+ ++ + P +G + LL ++ + +P QR Sbjct: 394 LWEIATGKIPFEGCDSKKIRELVAEDKKQEP--VGQDCPELLREIINECRAHEPSQR 448 >2R09-A nrPDB Length = 347 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 29/119 (24%) Query: 8 KEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRE-APLNNFSVAQCQLMKTE 66 +EGWL K G +KTW+ R+F+L ++ + Y E D + R PL N S+ + E Sbjct: 215 REGWLLKLGGRVKTWKRRWFILTDNCLY--YFEYTTDKEPRGIIPLENLSIRE-----VE 267 Query: 67 RPR-PNTFII-------------------RCLQWTTVIERTFHVETPEEREEWTTAIQT 105 PR PN F + R ++ V+ R +PEE+EEW +I+ Sbjct: 268 DPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYR-ISAPSPEEKEEWMKSIKA 325 >4MWI-A nrPDB Length = 294 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 47/184 (25%), Positives = 83/184 (45%), Gaps = 13/184 (7%) Query: 219 THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH-SEKNVVYRDLKL 277 T + VMEY G L L RE+ + + L LH SE ++ ++ Sbjct: 98 TPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRS 157 Query: 278 ENLMLDKDGHIKITDFGLCKE--GIKDGATMKTF--CGTPEYLAPEVLEDNDYGRAV--D 331 N ++ + +K+ F L K + G T + + YL+P+ LED Y V + Sbjct: 158 SNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSE 217 Query: 332 WWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK----D 387 + G+V++E+ G +PF + EK+ +L+ ++ + P LG + S L ++ + D Sbjct: 218 IYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEP--LGEDCPSELREIIDECRAHD 275 Query: 388 PKQR 391 P R Sbjct: 276 PSVR 279 >5VC6-A nrPDB Length = 289 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 65/276 (23%), Positives = 112/276 (40%), Gaps = 36/276 (13%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE--VAHTLTEN 199 K R T EF L+ +G G FG V ++ G YA+K KK + + DE + + Sbjct: 6 KSRYT-TEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAH 64 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE----RVFSEDRARFYGA 255 VL +H + ++ D + EY NGG L +S F E + Sbjct: 65 AVL--GQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLL 122 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDG-------------------HIKITDFGLC 296 ++ L Y+HS ++V+ D+K N+ + + KI D G Sbjct: 123 QVGRGLRYIHS-MSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG-- 179 Query: 297 KEGIKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 + ++ + G +LA EVL++N + D + L + + G P ++ + Sbjct: 180 --HVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVV-CAAGAEPL-PRNGD 235 Query: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 + E+ R P+ L E LL ++ DP++R Sbjct: 236 QWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERR 271 >4NFN-A nrPDB Length = 309 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 54/246 (21%), Positives = 100/246 (40%), Gaps = 45/246 (18%) Query: 128 NSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIV 187 + G E+ ++ P + V + ++ LK +G G FG++ Y AM +L +E + Sbjct: 4 SGGGEQADIL---PANYVVKDRWKVLKKIGGGGFGEI----------YEAMDLLTRENVA 50 Query: 188 AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLC-------------FVMEYANGGE 234 K E A +VL+ A+ Q D +C VM+ Sbjct: 51 LKVESAQQ--PKQVLKME-----VAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNL 103 Query: 235 LFFHLSRER-VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK----DGHIK 289 S+ R F+ G +I+ +++ +HS ++RD+K N + + Sbjct: 104 ADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSV-GFLHRDIKPSNFAMGRLPSTYRKCY 162 Query: 290 ITDFGLCKE------GIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343 + DFGL ++ ++ + F GT Y + ++ + GR D W L ++ E Sbjct: 163 MLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFA 222 Query: 344 CGRLPF 349 G+LP+ Sbjct: 223 VGQLPW 228 >3MY0-A nrPDB Length = 305 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 91/224 (40%), Gaps = 34/224 (15%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA---HTLTEN 199 R + ++ +GKG +G+V + G A+KI ++DE + T N Sbjct: 3 QRTVARQVALVECVGKGRYGEVW--RGLWHGESVAVKIFS-----SRDEQSWFRETEIYN 55 Query: 200 RVL--QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257 VL ++ F+ + S + +L + Y G L+ L R+ + R Sbjct: 56 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRL-AVSA 114 Query: 258 VSALDYLHSE-------KNVVYRDLKLENLMLDKDGHIKITDFGLC------KEGIKDGA 304 L +LH E + +RD K N+++ + I D GL + + G Sbjct: 115 ACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGN 174 Query: 305 TMKTFCGTPEYLAPEVLED---NDYGRAVDW---WGLGVVMYEM 342 + GT Y+APEVL++ D + W W G+V++E+ Sbjct: 175 NPRV--GTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEI 216 >4RT7-A nrPDB Length = 415 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 24/93 (25%), Positives = 50/93 (53%), Gaps = 3/93 (3%) Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA-TMKTFCG 311 + ++ +++L K+ V+RDL N+++ +KI DFGL ++ + D ++ Sbjct: 248 FAYQVAKGMEFLEF-KSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNAR 306 Query: 312 TP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343 P +++APE L + Y D W G++++E+ Sbjct: 307 LPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 339 >4NT4-A nrPDB Length = 312 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/119 (26%), Positives = 53/119 (44%), Gaps = 13/119 (10%) Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-----IKITDFGLCK 297 R FS +++ ++Y+HS ++++YRD+K EN ++ + I I DFGL K Sbjct: 109 RKFSLKTVLMIAKQLLHRIEYVHS-RHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK 167 Query: 298 EGIKDGAT-------MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 E I K+ GT Y++ + R D LG + + G LP+ Sbjct: 168 EYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPW 226 >3SOC-A nrPDB Length = 322 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 83/213 (38%), Gaps = 27/213 (12%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH-- 207 + L++ +G FG V K + Y A+KI + + E L +H Sbjct: 26 LQLLEVKARGRFGCVW--KAQLLNEYVAVKIFP----IQDKQSWQNEYEVYSLPGMKHEN 79 Query: 208 --PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 F+ A K L + + G L L + V S + + L YLH Sbjct: 80 ILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL-KANVVSWNELCHIAETMARGLAYLH 138 Query: 266 SE---------KNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPE 314 + + +RD+K +N++L + I DFGL E K GT Sbjct: 139 EDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRR 198 Query: 315 YLAPEVLE-----DNDYGRAVDWWGLGVVMYEM 342 Y+APEVLE D +D + +G+V++E+ Sbjct: 199 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 231 >5UV4-A nrPDB Length = 311 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 86/188 (45%), Gaps = 16/188 (8%) Query: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK---YSFQTHDRLCFVME 228 G +K LK+ +K E + E + L + RHP L L+ + + H+R+ + + Sbjct: 48 NGYMLTVKWLKEGFAKSKKEFSR---EIKKLGSVRHPNLVPLRGYYWGPKEHERI-MISD 103 Query: 229 YANGGELFFHLSR--ER---VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML- 282 YA+ L +LS ER S + +I LDYLH+E+ + + ++K N+++ Sbjct: 104 YADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQ 163 Query: 283 DKDGHIKITDFGLCKEGIKDGATMKTF-CGTPEYLAPEVLEDNDYGRAV--DWWGLGVVM 339 + +TD+ L + G + G Y PE + ++ D + GV++ Sbjct: 164 NSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVIL 223 Query: 340 YEMMCGRL 347 E++ G++ Sbjct: 224 LELLTGKI 231 >5X1R-A nrPDB Length = 302 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 44/223 (19%), Positives = 87/223 (39%), Gaps = 23/223 (10%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE---------------- 191 NEFE + +G+G FG V + R A+K + +++ Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 192 --VAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL-FFHLSRERVFSED 248 + + E R+L HP L + ++ + ++ +G L + E Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEA 140 Query: 249 RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT 308 R + SA++ +H E ++RD+ L+N+ + + + DFG ++ I + + Sbjct: 141 WIRRLLPPLFSAINTIHQE-GYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETE 199 Query: 309 FCGTPEYLAPEVLEDNDYGRAVDW---WGLGVVMYEMMCGRLP 348 P + E +N G W + LG V++ ++ G P Sbjct: 200 IVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 >5FQD-C nrPDB Length = 341 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 50/233 (21%), Positives = 95/233 (40%), Gaps = 21/233 (9%) Query: 130 GAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAK 189 G M S + +++ ++ +G G+FG + L G A+K+ ++ Sbjct: 1 GGGRMASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQK--ARH 58 Query: 190 DEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSE 247 ++ + ++LQ + +++ Q D VM+ +LF SR F+ Sbjct: 59 PQLLYESKLYKILQGGVG--IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRR--FTM 114 Query: 248 DRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIK---ITDFGLCKEGIKDGA 304 +++S ++Y+H+ KN ++RD+K +N ++ H + DFGL K+ +D Sbjct: 115 KTVLMLADQMISRIEYVHT-KNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKK-YRDNR 172 Query: 305 TM--------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 T K GT Y + + R D LG V+ LP+ Sbjct: 173 TRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW 225 >5X18-A nrPDB Length = 295 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/120 (25%), Positives = 57/120 (47%), Gaps = 15/120 (12%) Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG-----HIKITDFGLCK 297 R FS ++++ ++ LH+ +++YRD+K +N ++ + G +I + DFG+ K Sbjct: 98 RKFSVKTVVQVAVQMITLIEDLHAH-DLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAK 156 Query: 298 EGIKDGAT--------MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 + +D T K+ GT Y++ + R D LG V + + G LP+ Sbjct: 157 Q-YRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPW 215 >5VDK-A nrPDB Length = 297 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 9/140 (6%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE--VAHTLTENRVLQNSR 206 EF ++ +G G FG V ++ G YA+K K +E H + + VL Sbjct: 16 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVL--GH 73 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE----RVFSEDRARFYGAEIVSALD 262 HP + S+ D + EY NGG L +S F E + + +I L+ Sbjct: 74 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 133 Query: 263 YLHSEKNVVYRDLKLENLML 282 Y+H+ ++V+ D+K N+ + Sbjct: 134 YIHN-SSMVHLDIKPSNIFI 152 >4I94-A nrPDB Length = 300 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 33/141 (23%), Positives = 65/141 (46%), Gaps = 10/141 (7%) Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 316 I AL+Y S+ +Y DL ++ D D + +++ FGL K +DG K++ + Sbjct: 136 IAQALEYCTSKGRALYHDLNAYRVLFDDDANPRLSCFGLMKNS-RDG---KSYSTNLAFT 191 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRL--PFYNQD--HEKLFELILME--EIRFPR 370 PE L + G ++ +++ G+ P + D ++ ++++ E +F Sbjct: 192 PPEYLRTGRVTPESVIYSFGTLLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSS 251 Query: 371 TLGPEAKSLLSGLLKKDPKQR 391 G E L S L+ +P++R Sbjct: 252 DDGTELIRLASRCLQYEPRER 272 >5CLR-A nrPDB Length = 451 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 6/79 (7%) Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND- 325 E +++RDLK N+MLD D + DFG D GT YLAPE+ D Sbjct: 194 ELGLIHRDLKPGNIMLDADMQCHLVDFG---SSSSDKEPKPASWGTASYLAPELNAQEDF 250 Query: 326 --YGRAVDWWGLGVVMYEM 342 + + D + L + E+ Sbjct: 251 IAFSQVSDLFALAYSLDEL 269 >2W1Z-A nrPDB Length = 368 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 16/132 (12%) Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG----TPEYLAPEVLEDND 325 +V+ D ++ N++LD+ G + +T F + ++DGA+ + G PE A +L Sbjct: 212 LVHADFQVRNILLDQRGGVFLTGF---EHLVRDGASAVSPIGRGFAPPETTAERMLPYRQ 268 Query: 326 YGRAV-----DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 + + D W LG+ +Y + C LP E I P+ + ++LL Sbjct: 269 HHPTLMTFPFDTWTLGLAIYWIWCADLPNTEDAELGGIEWIYRRCKNIPQPV----RALL 324 Query: 381 SGLLKKDPKQRL 392 G L+ + RL Sbjct: 325 EGFLRYSKEDRL 336 >4WUA-A nrPDB Length = 401 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 36/151 (23%), Positives = 65/151 (43%), Gaps = 27/151 (17%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP- 208 + ++ LG G F V L + ++ AMK++K A+ L E R+L++ R+ Sbjct: 43 YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKS----AEHYTETALDEIRLLKSVRNSD 98 Query: 209 -----------FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRA------R 251 L K S +C V E L HL + + S + + Sbjct: 99 PNDPNREMVVQLLDDFKISGVNGTHICMVFEV-----LGHHLLKWIIKSNYQGLPLPCVK 153 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLML 282 +++ LDYLH++ +++ D+K EN++L Sbjct: 154 KIIQQVLQGLDYLHTKCRIIHTDIKPENILL 184 >2X7G-A nrPDB Length = 389 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 36/154 (23%), Positives = 64/154 (41%), Gaps = 27/154 (17%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP- 208 + ++ LG G F V L + R+ AMK++K A+ L E ++L+ R Sbjct: 33 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKS----AQHYTETALDEIKLLKCVRESD 88 Query: 209 -----------FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRA------R 251 + K S +C V E L HL + + S + + Sbjct: 89 PSDPNKDMVVQLIDDFKISGMNGIHVCMVFEV-----LGHHLLKWIIKSNYQGLPVRCVK 143 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 285 +++ LDYLHS+ +++ D+K EN+++ D Sbjct: 144 SIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVD 177 >5UU1-A nrPDB Length = 324 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 34/144 (23%), Positives = 58/144 (40%), Gaps = 18/144 (12%) Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 Y F +RL ++ +G + F + G ++ L+Y+H E V+ D Sbjct: 105 YRFMVMERLGIDLQKISG--------QNGTFKKSTVLQLGIRMLDVLEYIH-ENEYVHGD 155 Query: 275 LKLENLMLD--KDGHIKITDFGLCKEGIKDGA-------TMKTFCGTPEYLAPEVLEDND 325 +K NL+L + + D+GL +G K GT E+ + + + Sbjct: 156 IKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVA 215 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPF 349 R D LG M +CG+LP+ Sbjct: 216 LSRRSDVEILGYCMLRWLCGKLPW 239 >3DZO-A nrPDB Length = 413 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 67/148 (45%), Gaps = 21/148 (14%) Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---- 311 +++ L LH +V+ L+ +++LD+ G + +T F + ++DGA+ + G Sbjct: 219 QVIRLLASLH-HYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRDGASAVSPIGRGFA 274 Query: 312 TPEYLAPEVLEDNDYGR-----AVDWWGLGVVMYEMMCGRLPFYNQDHEKL--FELILME 364 PE A +L + A D W LG+ +Y + C LP N D L E I Sbjct: 275 PPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLP--NTDDAALGGSEWIFRS 332 Query: 365 EIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 P+ + ++LL G L+ + RL Sbjct: 333 CKNIPQPV----RALLEGFLRYPKEDRL 356 >3VIA-A nrPDB Length = 112 Score = 36.2 bits (82), Expect = 0.029, Method: Composition-based stats. Identities = 19/67 (28%), Positives = 37/67 (55%), Gaps = 2/67 (2%) Query: 4 VAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERP-QDV-DQREAPLNNFSVAQCQ 61 +A VK GWL ++ +K W+ +F L +DG I Y ++ Q++ D+ P++ ++ Q Sbjct: 3 MAFVKSGWLLRQSTILKRWKKNWFDLWSDGHLIYYDDQTRQNIEDKVHMPMDCINIRTGQ 62 Query: 62 LMKTERP 68 + +P Sbjct: 63 ECRDTQP 69 >1CSN-A nrPDB Length = 298 Score = 36.2 bits (82), Expect = 0.036, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 52/120 (43%), Gaps = 15/120 (12%) Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-----IKITDFGLCK 297 R FS ++++ + +H EK++VYRD+K +N ++ + I + DFG+ K Sbjct: 101 RKFSVKTVAMAAKQMLARVQSIH-EKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVK 159 Query: 298 EGIKDGAT--------MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 +D T K GT Y++ + R D LG V + G LP+ Sbjct: 160 F-YRDPVTKQHIPYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPW 218 >6J6I-B nrPDB Length = 351 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 33/139 (23%), Positives = 63/139 (45%), Gaps = 10/139 (7%) Query: 254 GAEIVSALDYLHSE--KNVVYRDLKLENLMLDKDGHIKITD--FGLCKEGIKDGATMKTF 309 G EI +A+ YLH+ K +++RD+K ++ LDK+ K++D F + K + Sbjct: 169 GKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWV 228 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR---LPFYNQDHEKLFELI--LME 364 GT Y+ P + D + G+ + ++ G+ + + D + + L+ L E Sbjct: 229 LGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKPAIMTISDGDLQGILSLVRELCE 288 Query: 365 EIRFPRTLGPE-AKSLLSG 382 + + P K + SG Sbjct: 289 NGKLDEVIDPRLMKDITSG 307 >3BYV-A nrPDB Length = 377 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 34/144 (23%), Positives = 62/144 (43%), Gaps = 12/144 (8%) Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF-GLCKEGIKDGATMKTFCGTPE 314 +++ L LH +V+ L+ +++LD+ G + +T F L ++G + +++ PE Sbjct: 214 QVIRLLASLH-HYGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGARVVSSVSRGFEPPE 272 Query: 315 YLAPEVLEDNDYGR------AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRF 368 A R + D W LG+V+Y + C LP E I Sbjct: 273 LEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEWIFRSCKNI 332 Query: 369 PRTLGPEAKSLLSGLLKKDPKQRL 392 P+ + ++LL G L+ + RL Sbjct: 333 PQPV----RALLEGFLRYPKEDRL 352 >3Q60-A nrPDB Length = 371 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 44/184 (23%), Positives = 75/184 (40%), Gaps = 13/184 (7%) Query: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF--LTALKYSFQTHDRLCFVMEYANG 232 + A ++L + A+D L + V S+ PF L+ + + + L + + Sbjct: 114 FAAARLLGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVD 173 Query: 233 GELFFH-LSRERVFSEDRA----RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287 EL F L VF D A+++ L S K +V+ +NL + DG Sbjct: 174 LELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQS-KGLVHGHFTPDNLFIMPDGR 232 Query: 288 IKITDF-GLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 345 + + D L K G + A+ P E+L + A++ W LG+ +Y + C Sbjct: 233 LMLGDVSALWKVGTRGPASSVPVTYAPREFLNAST---ATFTHALNAWQLGLSIYRVWCL 289 Query: 346 RLPF 349 LPF Sbjct: 290 FLPF 293 >4L68-A nrPDB Length = 340 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 7/147 (4%) Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF-YGAEIVSALDYL 264 RH L L + V +Y + G L L R + RF G L +L Sbjct: 93 RHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWL 152 Query: 265 H--SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF----CGTPEYLAP 318 H ++++++ +++D+D +I D GL + + +F G Y+AP Sbjct: 153 HHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAP 212 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCG 345 E D +GLGVV+ E+ G Sbjct: 213 EYSTTMLASLKGDVYGLGVVLLELATG 239 >5USZ-A nrPDB Length = 289 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 51/274 (18%), Positives = 103/274 (37%), Gaps = 41/274 (14%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY---YAMKILKKEVIVAKDEVAHTLTEN 199 H++ + + + LG+GTF K+ + G Y + ++L K + A + + E Sbjct: 3 HKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEA 62 Query: 200 RVLQNSRHPFLTALKYSFQT-HDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 + + L Y D V E+ G L +L + + + A+ + Sbjct: 63 ASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQL 122 Query: 259 SALDYLHSEKNVVYRDLKLENLML-----DKDGH---IKITDFGLCKEGIKDGATMKTFC 310 +A + E +++ ++ +N++L K G+ IK++D G+ + + Sbjct: 123 AAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIP 182 Query: 311 GTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCG------------RLPFYNQDHEKL 357 P PE +E+ + A D W G ++E+ G +L FY H+ Sbjct: 183 WVP----PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQ-- 236 Query: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 P E +L++ + +P R Sbjct: 237 ----------LPAPKAAELANLINNCMDYEPDHR 260 >2DHJ-A nrPDB Length = 125 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 26/112 (23%), Positives = 43/112 (38%), Gaps = 14/112 (12%) Query: 7 VKEGWLHKR----------GEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFS 56 KEGWLH R G I+ W+ Y +L+ ++ +R Q E + + Sbjct: 10 AKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEEEQPISVN 69 Query: 57 VAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVAD 108 + +E R N F + T+ E F E ++ W IQ ++ Sbjct: 70 ACLIDISYSETKRKNVFRLT----TSDCECLFQAEDRDDMLAWIKTIQESSN 117 >2DHI-A nrPDB Length = 120 Score = 33.1 bits (74), Expect = 0.30, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 49/105 (46%), Gaps = 10/105 (9%) Query: 7 VKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDV--DQREAPLNNFSVA---QCQ 61 VK GWL ++ +K W+ +F L +DG I Y ++ + D+ P++ ++ +C+ Sbjct: 9 VKSGWLLRQSTILKRWKKNWFDLWSDGHLIYYDDQTRQSIEDKVHMPVDCINIRTGHECR 68 Query: 62 LMKTE--RPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQ 104 ++ +PR I C T+ + E+ ++ W +Q Sbjct: 69 DIQPPDGKPRDCLLQIVCRDGKTI---SLCAESTDDCLAWKFTLQ 110 >2J59-M nrPDB Length = 168 Score = 32.0 bits (71), Expect = 0.62, Method: Compositional matrix adjust. Identities = 29/117 (24%), Positives = 46/117 (39%), Gaps = 16/117 (13%) Query: 2 SDVAIVKEGWLHKR----------GEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAP 51 SD A KEGWLH R G I+ W+ Y +L+ ++ +R Q E Sbjct: 1 SDAA--KEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEEEQ 58 Query: 52 LNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVAD 108 + + + +E R N F + T+ E F E ++ W IQ ++ Sbjct: 59 PISVNACLIDISYSETKRKNVFRLT----TSDCECLFQAEDRDDMLAWIKTIQESSN 111 >2D9V-A nrPDB Length = 130 Score = 31.2 bits (69), Expect = 0.91, Method: Composition-based stats. Identities = 16/46 (34%), Positives = 26/46 (56%), Gaps = 3/46 (6%) Query: 5 AIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGY--KERPQDVDQR 48 +V+ GWL ++ ++ W+ +F L DGT +GY E QD + R Sbjct: 7 GLVRGGWLWRQSSILRRWKRNWFALWLDGT-LGYYHDETAQDEEDR 51 >1V5U-A nrPDB Length = 117 Score = 29.6 bits (65), Expect = 3.4, Method: Compositional matrix adjust. Identities = 10/21 (47%), Positives = 17/21 (80%) Query: 9 EGWLHKRGEYIKTWRPRYFLL 29 EG L+K+G ++K W+ R+F+L Sbjct: 11 EGILYKKGAFMKPWKARWFVL 31 >6E31-A nrPDB Length = 359 Score = 29.3 bits (64), Expect = 4.0, Method: Compositional matrix adjust. Identities = 20/75 (26%), Positives = 38/75 (50%), Gaps = 10/75 (13%) Query: 9 EGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAP-------LNNFSVAQCQ 61 EG L+ + + K+W+ RYFLL+ G + Y + + R+ +N + QC+ Sbjct: 239 EGALYLKEDGKKSWKRRYFLLRASGIY--YVPKGKTKTSRDLACFIQFENVNIYYGIQCK 296 Query: 62 LMKTERPRPNTFIIR 76 MK + P + F+++ Sbjct: 297 -MKYKAPTDHCFVLK 310 >3TCA-A nrPDB Length = 291 Score = 29.3 bits (64), Expect = 4.1, Method: Compositional matrix adjust. Identities = 20/75 (26%), Positives = 38/75 (50%), Gaps = 10/75 (13%) Query: 9 EGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAP-------LNNFSVAQCQ 61 EG L+ + + K+W+ RYFLL+ G + Y + + R+ +N + QC+ Sbjct: 171 EGALYLKEDGKKSWKRRYFLLRASGIY--YVPKGKTKTSRDLACFIQFENVNIYYGIQCK 228 Query: 62 LMKTERPRPNTFIIR 76 MK + P + F+++ Sbjct: 229 -MKYKAPTDHCFVLK 242 >6EMW-E nrPDB Length = 181 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 36/77 (46%), Gaps = 2/77 (2%) Query: 152 YLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLT 211 +++L + T +L+ E G+ + L + ++ +EV TL + RV+ + Sbjct: 31 VIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQAIV--NNEVPETLKDKRVMSLDMGTVVA 88 Query: 212 ALKYSFQTHDRLCFVME 228 KY + +RL VME Sbjct: 89 GTKYRGEFEERLKKVME 105 >6EM8-A nrPDB Length = 818 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 19/76 (25%), Positives = 36/76 (47%), Gaps = 2/76 (2%) Query: 153 LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 +++L + T +L+ E G+ + L + ++ +EV TL + RV+ + Sbjct: 193 IEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQAIV--NNEVPETLKDKRVMSLDMGTVVAG 250 Query: 213 LKYSFQTHDRLCFVME 228 KY + +RL VME Sbjct: 251 TKYRGEFEERLKKVME 266 >3J3U-A nrPDB Length = 810 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 19/76 (25%), Positives = 36/76 (47%), Gaps = 2/76 (2%) Query: 153 LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 +++L + T +L+ E G+ + L +++I +EV L + RV+ + Sbjct: 193 IEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQII--NNEVPEILRDKRVMTLDMGTVVAG 250 Query: 213 LKYSFQTHDRLCFVME 228 KY + DRL VM+ Sbjct: 251 TKYRGEFEDRLKKVMD 266 >5DMZ-A nrPDB Length = 365 Score = 28.1 bits (61), Expect = 9.5, Method: Compositional matrix adjust. Identities = 20/117 (17%), Positives = 49/117 (41%), Gaps = 14/117 (11%) Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML-----------DKDGHIKI 290 E+V + + ++ ++ +H + +++ D+K +N +L D + + Sbjct: 166 EKVMPQGLVISFAMRMLYMIEQVH-DCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLAL 224 Query: 291 TDFG--LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 345 D G + + G C T + E+L + + +D++G+ +Y M+ G Sbjct: 225 IDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFG 281 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5KCV-A nrPDB 699 0.0 3MV5-A nrPDB 502 e-142 2JDO-A nrPDB 463 e-131 3PFQ-A nrPDB 420 e-118 4RA4-A nrPDB 393 e-109 4L42-A nrPDB 391 e-109 2I0E-A nrPDB 387 e-108 3TXO-A nrPDB 383 e-107 5F9E-A nrPDB 378 e-105 3HDN-A nrPDB 377 e-105 4OTD-A nrPDB 372 e-103 4CRS-A nrPDB 371 e-103 5D9K-A nrPDB 364 e-101 3A8W-A nrPDB 364 e-101 2Z7Q-A nrPDB 358 4e-99 5N23-A nrPDB 350 6e-97 4RLP-A nrPDB 348 2e-96 4WB7-A nrPDB 348 4e-96 5X3F-B nrPDB 348 4e-96 1FOT-A nrPDB 346 8e-96 1VZO-A nrPDB 331 3e-91 6BDL-A nrPDB 321 4e-88 3TKU-A nrPDB 321 6e-88 5FET-A nrPDB 319 2e-87 4AW2-A nrPDB 318 5e-87 5LOH-A nrPDB 316 2e-86 3NYO-A nrPDB 312 2e-85 6E9W-A nrPDB 311 4e-85 2VD5-A nrPDB 310 9e-85 5YKS-A nrPDB 309 2e-84 5DYK-A nrPDB 309 2e-84 6ED6-A nrPDB 307 8e-84 5ES1-A nrPDB 305 3e-83 4TNB-A nrPDB 305 3e-83 5KZ7-A nrPDB 304 5e-83 2QNJ-A nrPDB 302 2e-82 3HZT-A nrPDB 301 6e-82 3DXN-A nrPDB 300 8e-82 2VN9-A nrPDB 300 9e-82 4REW-A nrPDB 299 2e-81 4MVF-A nrPDB 299 2e-81 3MN3-A nrPDB 299 2e-81 5FG8-A nrPDB 298 3e-81 4CFF-A nrPDB 298 3e-81 5UUU-A nrPDB 298 3e-81 5EZV-A nrPDB 298 4e-81 3PVW-A nrPDB 298 5e-81 4RED-A nrPDB 297 8e-81 5JN2-A nrPDB 297 8e-81 4CFH-A nrPDB 297 9e-81 2JC6-A nrPDB 296 1e-80 4CZT-A nrPDB 296 1e-80 4FG9-A nrPDB 296 1e-80 5U6Y-A nrPDB 295 2e-80 2V7O-A nrPDB 295 2e-80 2VZ6-A nrPDB 295 3e-80 3H4J-B nrPDB 295 3e-80 2YZA-A nrPDB 295 3e-80 3BHH-A nrPDB 294 7e-80 5IG1-A nrPDB 294 7e-80 4D28-A nrPDB 293 8e-80 3MA6-A nrPDB 293 2e-79 3ORZ-A nrPDB 292 2e-79 2BDW-A nrPDB 292 3e-79 3SOA-A nrPDB 290 9e-79 4JXF-A nrPDB 290 1e-78 3KK8-A nrPDB 289 1e-78 4YHJ-A nrPDB 289 1e-78 4UZD-A nrPDB 288 3e-78 6BXI-A nrPDB 288 5e-78 4LQP-A nrPDB 288 5e-78 3C51-A nrPDB 287 6e-78 3D2K-A nrPDB 287 7e-78 3NCG-A nrPDB 285 3e-77 3LIJ-A nrPDB 285 4e-77 3DFA-A nrPDB 284 4e-77 4CQG-A nrPDB 284 5e-77 2HAK-A nrPDB 284 5e-77 2JAM-A nrPDB 283 1e-76 4RGJ-A nrPDB 282 1e-76 3COM-A nrPDB 282 2e-76 4YZB-A nrPDB 282 2e-76 4FR4-A nrPDB 282 3e-76 6C9D-A nrPDB 281 4e-76 4D2V-A nrPDB 280 8e-76 3DB8-A nrPDB 278 3e-75 4JG6-A nrPDB 277 8e-75 4LG4-A nrPDB 276 1e-74 4YNZ-A nrPDB 276 1e-74 4NIF-A nrPDB 275 2e-74 4I6B-A nrPDB 275 3e-74 5WAX-A nrPDB 275 3e-74 3Q5I-A nrPDB 274 8e-74 6AO5-A nrPDB 273 1e-73 4B8L-A nrPDB 273 1e-73 5XZW-A nrPDB 273 1e-73 2W4O-A nrPDB 272 2e-73 4CSV-A nrPDB 272 2e-73 6FD3-A nrPDB 272 3e-73 2OU7-A nrPDB 272 3e-73 4B6L-A nrPDB 272 3e-73 4J52-A nrPDB 271 3e-73 2YCR-A nrPDB 271 5e-73 3F3Z-A nrPDB 271 6e-73 5JZN-A nrPDB 271 7e-73 2J90-A nrPDB 270 8e-73 4C0T-A nrPDB 270 1e-72 3UC3-A nrPDB 270 1e-72 2YAB-A nrPDB 270 1e-72 4QMW-A nrPDB 269 1e-72 3ZUT-A nrPDB 269 2e-72 6CMJ-A nrPDB 269 2e-72 5J5T-A nrPDB 269 2e-72 4AF3-A nrPDB 267 6e-72 3UDB-A nrPDB 267 1e-71 3TAC-A nrPDB 266 2e-71 2A27-A nrPDB 265 3e-71 3Q53-A nrPDB 265 3e-71 4XBR-A nrPDB 264 5e-71 1ZWS-A nrPDB 264 6e-71 6FDY-U nrPDB 264 6e-71 3GUB-A nrPDB 263 1e-70 3I6U-A nrPDB 263 1e-70 2BPM-A nrPDB 262 2e-70 4FIE-A nrPDB 262 3e-70 4PDS-A nrPDB 262 3e-70 2F57-A nrPDB 261 4e-70 1PHK-A nrPDB 261 5e-70 3KN6-A nrPDB 261 6e-70 2XIK-A nrPDB 260 8e-70 5YV8-A nrPDB 260 1e-69 2Q0N-A nrPDB 259 1e-69 4KS7-A nrPDB 259 2e-69 2Y7J-A nrPDB 259 2e-69 4JDH-A nrPDB 259 2e-69 4XEY-B nrPDB 257 5e-69 4APC-A nrPDB 257 5e-69 6HXF-B nrPDB 257 6e-69 2FO0-A nrPDB 257 9e-69 4FZF-B nrPDB 257 9e-69 1CM8-A nrPDB 257 1e-68 2UV2-A nrPDB 256 1e-68 2XYN-A nrPDB 256 1e-68 3PPZ-A nrPDB 256 2e-68 6NPU-A nrPDB 256 2e-68 3IS5-A nrPDB 255 3e-68 3DAK-A nrPDB 253 1e-67 4AGU-A nrPDB 253 1e-67 2X4F-A nrPDB 252 3e-67 3TT0-A nrPDB 252 3e-67 5D7A-A nrPDB 252 3e-67 4BBM-A nrPDB 251 4e-67 3NIZ-A nrPDB 251 6e-67 5A46-A nrPDB 251 8e-67 4KRC-A nrPDB 249 2e-66 3UTO-A nrPDB 249 2e-66 3GQL-A nrPDB 249 3e-66 6GU6-A nrPDB 248 4e-66 3V5Q-A nrPDB 248 4e-66 2WQN-A nrPDB 247 8e-66 3DTC-A nrPDB 247 8e-66 1KOA-A nrPDB 247 9e-66 4UY9-A nrPDB 247 9e-66 5DBX-A nrPDB 246 2e-65 6CQF-A nrPDB 246 2e-65 5AMN-A nrPDB 245 3e-65 4WNO-A nrPDB 245 4e-65 4AT3-A nrPDB 245 4e-65 1KOB-A nrPDB 244 5e-65 4AN9-A nrPDB 244 6e-65 3HKO-A nrPDB 244 8e-65 3FXW-A nrPDB 243 1e-64 2PSQ-A nrPDB 242 2e-64 4AU8-A nrPDB 242 2e-64 3VN9-A nrPDB 242 3e-64 4EWQ-A nrPDB 242 3e-64 1JNK-A nrPDB 241 4e-64 3E7O-A nrPDB 241 4e-64 4K33-A nrPDB 241 4e-64 2HW6-A nrPDB 241 4e-64 2XNP-A nrPDB 241 5e-64 4XLV-A nrPDB 241 7e-64 5KMM-A nrPDB 241 7e-64 2XS0-A nrPDB 241 7e-64 3OHT-A nrPDB 241 8e-64 2Y6O-A nrPDB 241 8e-64 4P5Q-A nrPDB 241 8e-64 4XCU-A nrPDB 240 8e-64 4QNY-A nrPDB 240 8e-64 3ZDU-A nrPDB 240 1e-63 5FM2-A nrPDB 240 1e-63 6CCF-A nrPDB 240 1e-63 2H8H-A nrPDB 240 1e-63 4UYA-A nrPDB 239 1e-63 4BGQ-A nrPDB 239 2e-63 5X5O-A nrPDB 239 2e-63 4GS6-A nrPDB 239 2e-63 6GQK-A nrPDB 239 3e-63 5H2U-A nrPDB 239 3e-63 6DTL-A nrPDB 239 3e-63 3DKO-A nrPDB 238 3e-63 6QAU-A nrPDB 238 4e-63 6F3F-A nrPDB 238 4e-63 4H1J-A nrPDB 238 4e-63 4E93-A nrPDB 237 5e-63 5VO2-A nrPDB 237 6e-63 4IC8-A nrPDB 237 7e-63 3OZ6-A nrPDB 237 1e-62 4ZSG-A nrPDB 237 1e-62 2F9G-A nrPDB 236 2e-62 2R2P-A nrPDB 236 2e-62 4EBW-A nrPDB 236 2e-62 1V0B-A nrPDB 236 2e-62 6CKI-A nrPDB 236 2e-62 1JPA-A nrPDB 236 2e-62 2DQ7-X nrPDB 236 2e-62 5AWM-A nrPDB 236 3e-62 5MJB-A nrPDB 236 3e-62 4MYG-A nrPDB 235 3e-62 5EG3-A nrPDB 235 3e-62 1FVR-A nrPDB 235 3e-62 1NY3-A nrPDB 235 4e-62 4U41-A nrPDB 235 4e-62 5SYS-A nrPDB 235 4e-62 1U5R-A nrPDB 234 6e-62 2OZA-A nrPDB 234 7e-62 3QGY-A nrPDB 234 7e-62 2J0K-A nrPDB 234 9e-62 2OGV-A nrPDB 233 1e-61 3KA0-A nrPDB 233 1e-61 3A4O-X nrPDB 233 1e-61 5L6P-A nrPDB 233 1e-61 1G3N-A nrPDB 233 2e-61 3FME-A nrPDB 232 2e-61 5X02-A nrPDB 232 2e-61 3C1X-A nrPDB 232 2e-61 6FEX-A nrPDB 232 3e-61 2GCD-A nrPDB 232 3e-61 1LUF-A nrPDB 232 3e-61 3FI2-A nrPDB 232 3e-61 6BSD-A nrPDB 232 4e-61 1UA2-A nrPDB 231 4e-61 5Z33-A nrPDB 231 4e-61 3KUL-B nrPDB 231 5e-61 3KRL-A nrPDB 231 5e-61 4O2Z-A nrPDB 230 7e-61 2VWV-A nrPDB 230 9e-61 4NST-A nrPDB 230 1e-60 3BEA-A nrPDB 230 1e-60 3CJF-A nrPDB 230 1e-60 6E2O-A nrPDB 229 2e-60 4XUF-A nrPDB 229 2e-60 4R7H-A nrPDB 229 2e-60 5KKR-C nrPDB 229 3e-60 3LM0-A nrPDB 228 3e-60 3GC9-A nrPDB 228 4e-60 2PL0-A nrPDB 227 6e-60 3G0E-A nrPDB 227 7e-60 2HK5-A nrPDB 227 7e-60 3EQC-A nrPDB 227 7e-60 3ALO-A nrPDB 227 1e-59 6E4F-A nrPDB 226 1e-59 5EFQ-A nrPDB 226 1e-59 5NGU-A nrPDB 226 1e-59 3GC0-A nrPDB 226 1e-59 5GRN-A nrPDB 226 1e-59 3QUP-A nrPDB 226 2e-59 4PDO-A nrPDB 226 2e-59 5G6V-A nrPDB 225 3e-59 4Y93-A nrPDB 225 4e-59 1K9A-A nrPDB 225 4e-59 1BYG-A nrPDB 225 5e-59 4XI2-A nrPDB 224 1e-58 3HMP-A nrPDB 223 1e-58 2UVM-A nrPDB 222 2e-58 4HZS-A nrPDB 222 2e-58 5HI2-A nrPDB 222 2e-58 4QTB-A nrPDB 222 2e-58 3SXS-A nrPDB 222 4e-58 2ZMD-A nrPDB 221 4e-58 5O2B-A nrPDB 221 4e-58 3ZBF-A nrPDB 221 4e-58 1U54-B nrPDB 221 5e-58 3I81-A nrPDB 221 5e-58 3MIA-A nrPDB 221 5e-58 3OMV-A nrPDB 221 6e-58 3ORP-A nrPDB 220 8e-58 4OLI-A nrPDB 220 1e-57 1AD5-A nrPDB 220 1e-57 6DBM-A nrPDB 219 2e-57 2WTK-C nrPDB 219 3e-57 5B2L-A nrPDB 219 3e-57 5ZTN-A nrPDB 219 3e-57 3RP9-A nrPDB 218 4e-57 1S9I-A nrPDB 218 5e-57 1TKI-A nrPDB 217 7e-57 5O2C-A nrPDB 217 1e-56 2BRG-A nrPDB 217 1e-56 4PWN-A nrPDB 217 1e-56 5U6B-A nrPDB 217 1e-56 6FER-A nrPDB 216 2e-56 5HIE-A nrPDB 216 2e-56 2W1I-A nrPDB 215 3e-56 3DLS-A nrPDB 215 4e-56 3IO7-A nrPDB 215 4e-56 3BBT-B nrPDB 215 4e-56 2W96-B nrPDB 214 6e-56 5Y86-A nrPDB 214 9e-56 4YFF-A nrPDB 213 1e-55 5U6C-A nrPDB 213 2e-55 4E20-A nrPDB 213 2e-55 5AIR-A nrPDB 212 3e-55 6DBN-A nrPDB 211 4e-55 6GVJ-A nrPDB 211 5e-55 1U59-A nrPDB 210 7e-55 5HLW-A nrPDB 210 7e-55 5O0Y-A nrPDB 210 8e-55 2OZO-A nrPDB 210 8e-55 4IDT-A nrPDB 210 9e-55 4E7W-A nrPDB 210 1e-54 2I6L-A nrPDB 210 1e-54 4OW8-A nrPDB 210 1e-54 4X3F-A nrPDB 210 2e-54 6B2Q-A nrPDB 209 2e-54 1ZXE-A nrPDB 209 2e-54 4EQM-A nrPDB 209 2e-54 4HVI-A nrPDB 208 4e-54 3BGP-A nrPDB 208 4e-54 5AP3-A nrPDB 207 7e-54 4F0G-A nrPDB 207 8e-54 5TUR-A nrPDB 207 9e-54 3LZB-A nrPDB 207 9e-54 4X7Q-B nrPDB 207 1e-53 4RC3-A nrPDB 206 2e-53 3E3P-A nrPDB 206 2e-53 3PP0-A nrPDB 206 2e-53 5GNK-A nrPDB 205 2e-53 3PLS-A nrPDB 205 3e-53 3AOX-A nrPDB 204 6e-53 5TQX-A nrPDB 204 9e-53 3M42-A nrPDB 203 1e-52 5HVK-A nrPDB 203 2e-52 3N9X-A nrPDB 202 2e-52 2X18-A nrPDB 202 3e-52 3NIE-A nrPDB 202 4e-52 4M7I-A nrPDB 201 5e-52 3PG1-A nrPDB 201 5e-52 6CTH-A nrPDB 200 1e-51 2A1A-B nrPDB 199 2e-51 4LRM-A nrPDB 199 3e-51 4TPT-A nrPDB 198 5e-51 4KIK-B nrPDB 197 7e-51 5WNO-A nrPDB 197 7e-51 4Y83-A nrPDB 197 9e-51 3QA8-A nrPDB 197 9e-51 5TOS-A nrPDB 197 1e-50 4FL3-A nrPDB 196 2e-50 5WNL-A nrPDB 196 2e-50 5UIU-A nrPDB 196 2e-50 5LPZ-A nrPDB 195 3e-50 4NEU-A nrPDB 195 3e-50 5LPV-A nrPDB 194 5e-50 3EB0-A nrPDB 194 5e-50 3UIU-A nrPDB 193 1e-49 5X8I-B nrPDB 193 2e-49 5C26-A nrPDB 192 2e-49 5VD3-A nrPDB 192 3e-49 6J5U-C nrPDB 191 4e-49 2PMN-X nrPDB 190 1e-48 2WO6-A nrPDB 190 2e-48 4G3E-A nrPDB 189 2e-48 3ZZW-A nrPDB 189 2e-48 6FYV-A nrPDB 189 3e-48 6O6Q-A nrPDB 187 1e-47 4C59-A nrPDB 187 1e-47 3UIM-A nrPDB 182 2e-46 2H34-A nrPDB 182 2e-46 3LMG-A nrPDB 182 4e-46 3MDY-A nrPDB 181 5e-46 3Q4U-A nrPDB 180 9e-46 5AR8-A nrPDB 180 1e-45 2RIO-A nrPDB 178 5e-45 6DC0-A nrPDB 176 2e-44 5CEK-A nrPDB 176 2e-44 5TE0-A nrPDB 175 3e-44 4MD7-E nrPDB 174 7e-44 6HMD-A nrPDB 174 9e-44 4CRL-A nrPDB 173 1e-43 5L2Q-C nrPDB 173 1e-43 3RAW-A nrPDB 173 1e-43 2PVN-A nrPDB 173 1e-43 4JLC-A nrPDB 173 2e-43 2QKW-B nrPDB 172 2e-43 3MY0-A nrPDB 172 4e-43 1PY5-A nrPDB 172 4e-43 4EUU-A nrPDB 172 4e-43 5XD6-A nrPDB 172 5e-43 5UNP-A nrPDB 171 5e-43 6EII-A nrPDB 171 5e-43 5XVU-A nrPDB 171 6e-43 5IKW-A nrPDB 171 6e-43 2BUJ-A nrPDB 171 7e-43 4EUT-A nrPDB 171 7e-43 4MWI-A nrPDB 170 1e-42 6NT9-A nrPDB 169 3e-42 6O8B-A nrPDB 168 3e-42 6BFN-A nrPDB 168 4e-42 5VC6-A nrPDB 168 5e-42 2Y4I-B nrPDB 167 7e-42 4IAN-A nrPDB 165 5e-41 4M66-A nrPDB 164 7e-41 3REP-A nrPDB 164 8e-41 4BTF-A nrPDB 163 1e-40 4M69-B nrPDB 163 1e-40 6HV0-A nrPDB 163 1e-40 2JD5-A nrPDB 163 2e-40 4PL5-B nrPDB 163 2e-40 5E8V-A nrPDB 162 3e-40 3LLT-A nrPDB 162 4e-40 3QD2-B nrPDB 161 7e-40 3SOC-A nrPDB 158 4e-39 3HNG-A nrPDB 158 5e-39 3VHK-A nrPDB 158 7e-39 3G2F-A nrPDB 157 7e-39 4BTK-A nrPDB 155 3e-38 5FQD-C nrPDB 153 1e-37 4LFI-A nrPDB 153 2e-37 5VDK-A nrPDB 151 5e-37 2QLU-A nrPDB 151 6e-37 4NFN-A nrPDB 150 2e-36 4TN6-A nrPDB 148 4e-36 5J0A-A nrPDB 148 4e-36 4RT7-A nrPDB 148 6e-36 5X1R-A nrPDB 147 8e-36 3SV0-A nrPDB 147 1e-35 5C01-A nrPDB 145 3e-35 2CHL-A nrPDB 145 3e-35 2CMW-A nrPDB 143 2e-34 2C47-A nrPDB 140 1e-33 4F9B-A nrPDB 140 1e-33 4WOV-A nrPDB 140 1e-33 5M07-A nrPDB 140 2e-33 5X18-A nrPDB 138 4e-33 4NT4-A nrPDB 135 3e-32 5OAT-A nrPDB 129 3e-30 6BBQ-A nrPDB 124 7e-29 2PZI-A nrPDB 124 1e-28 4Y12-A nrPDB 123 1e-28 2R09-A nrPDB 123 1e-28 5UV4-A nrPDB 121 9e-28 4JRN-A nrPDB 118 5e-27 6EQI-C nrPDB 114 7e-26 Sequences not found previously or not previously below threshold: 2WTK-B nrPDB 162 3e-40 2X7G-A nrPDB 150 1e-36 4WUA-A nrPDB 148 5e-36 4L00-A nrPDB 141 9e-34 5USZ-A nrPDB 135 3e-32 1CSN-A nrPDB 127 1e-29 4XHH-A nrPDB 126 3e-29 4XHL-A nrPDB 123 2e-28 4L68-A nrPDB 115 6e-26 4I94-A nrPDB 113 1e-25 6J6I-B nrPDB 110 2e-24 5UU1-A nrPDB 92 6e-19 5CLR-A nrPDB 85 9e-17 6EAS-A nrPDB 84 1e-16 4O1O-A nrPDB 80 2e-15 2RSV-A nrPDB 79 5e-15 2LAV-A nrPDB 78 6e-15 5DMZ-A nrPDB 75 7e-14 4OAU-C nrPDB 75 1e-13 4IX6-A nrPDB 70 2e-12 6M7Z-A nrPDB 70 2e-12 6G4J-A nrPDB 70 2e-12 6BHC-A nrPDB 66 3e-11 5GZA-A nrPDB 63 2e-10 5GZ9-A nrPDB 62 6e-10 6EWX-A nrPDB 62 7e-10 2JII-A nrPDB 61 1e-09 4CI6-B nrPDB 59 5e-09 6G38-A nrPDB 55 5e-08 4CYJ-A nrPDB 53 3e-07 3BYV-A nrPDB 53 3e-07 4CZY-B nrPDB 52 5e-07 2W1Z-A nrPDB 51 8e-07 4AZW-A nrPDB 51 9e-07 4AZV-A nrPDB 51 1e-06 3DZO-A nrPDB 50 2e-06 6R5K-O nrPDB 50 3e-06 3ENH-A nrPDB 49 4e-06 4XR7-L nrPDB 49 5e-06 5VE6-A nrPDB 47 2e-05 3Q60-A nrPDB 45 1e-04 4OTP-A nrPDB 44 1e-04 6G5I-z nrPDB 44 1e-04 1TQM-A nrPDB 44 1e-04 3VIA-A nrPDB 44 1e-04 4BWP-A nrPDB 44 2e-04 2DHI-A nrPDB 43 2e-04 4WWA-A nrPDB 41 8e-04 >5KCV-A nrPDB Length = 460 Score = 699 bits (1804), Expect = 0.0, Method: Composition-based stats. Identities = 442/445 (99%), Positives = 442/445 (99%) Query: 2 SDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQ 61 SDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQ Sbjct: 16 SDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQ 75 Query: 62 LMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFR 121 LMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQ EMDFR Sbjct: 76 LMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQAAAEMDFR 135 Query: 122 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL 181 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL Sbjct: 136 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL 195 Query: 182 KKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR 241 KKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR Sbjct: 196 KKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR 255 Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK Sbjct: 256 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 315 Query: 302 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 361 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI Sbjct: 316 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 375 Query: 362 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKL 421 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKL Sbjct: 376 LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKL 435 Query: 422 SPPFKPQVTSETDTRYFDEEFTAQM 446 SPPFKPQVTSETDTRYFDEEFTAQM Sbjct: 436 SPPFKPQVTSETDTRYFDEEFTAQM 460 >3MV5-A nrPDB Length = 342 Score = 502 bits (1293), Expect = e-142, Method: Composition-based stats. Identities = 335/337 (99%), Positives = 335/337 (99%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ Sbjct: 6 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 65 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY Sbjct: 66 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 125 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED Sbjct: 126 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 185 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL Sbjct: 186 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 245 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 443 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT Sbjct: 246 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 305 Query: 444 AQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480 AQMITITPPDQDDSMECVDSERRPHFPQF YSAS TA Sbjct: 306 AQMITITPPDQDDSMECVDSERRPHFPQFDYSASSTA 342 >2JDO-A nrPDB Length = 342 Score = 463 bits (1191), Expect = e-131, Method: Composition-based stats. Identities = 282/336 (83%), Positives = 309/336 (91%), Gaps = 4/336 (1%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +VTMN+F+YLKLLGKGTFGKVILV+EKATGRYYAMKIL+KEVI+AKDEVAHT+TE+RVLQ Sbjct: 6 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 N+RHPFLTALKY+FQTHDRLCFVMEYANGGELFFHLSRERVF+E+RARFYGAEIVSAL+Y Sbjct: 66 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 125 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LHS ++VVYRD+KLENLMLDKDGHIKITDFGLCKEGI DGATMKTFCGTPEYLAPEVLED Sbjct: 126 LHS-RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 184 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LFELILMEEIRFPRTL PEAKSLL+GL Sbjct: 185 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 244 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 443 LKKDPKQRLGGG DAKE+M+HRFF I WQ V +KKL PPFKPQVTSE DTRYFD+EFT Sbjct: 245 LKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 304 Query: 444 AQMITITPPDQDDSMECVD---SERRPHFPQFSYSA 476 AQ ITITPPD+ DS+ ++ E + F F Y A Sbjct: 305 AQSITITPPDRYDSLGLLELDQREEQEMFEDFDYIA 340 >3PFQ-A nrPDB Length = 674 Score = 420 bits (1081), Expect = e-118, Method: Composition-based stats. Identities = 166/395 (42%), Positives = 237/395 (60%), Gaps = 21/395 (5%) Query: 88 FHVETPEE----REEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKH 143 F+V P E EE + G + EE + S DN+G + Sbjct: 287 FNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGN----------RD 336 Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E RVL Sbjct: 337 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 396 Query: 204 N-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI L Sbjct: 397 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE++ Sbjct: 457 FLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 515 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++ G Sbjct: 516 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 575 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442 L+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ + FD F Sbjct: 576 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRN-AENFDRFF 634 Query: 443 TAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477 T +TPPDQ E + + + F FS+ S Sbjct: 635 TRHPPVLTPPDQ----EVIRNIDQSEFEGFSFVNS 665 >4RA4-A nrPDB Length = 355 Score = 393 bits (1009), Expect = e-109, Method: Composition-based stats. Identities = 152/336 (45%), Positives = 219/336 (65%), Gaps = 7/336 (2%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 RV + +F +L +LGKG+FGKV+L K T YA+KILKK+V++ D+V T+ E RVL Sbjct: 15 DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVL 74 Query: 203 QNSRHP-FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 P FLT L FQT DRL FVMEY NGG+L +H+ + F E +A FY AEI L Sbjct: 75 ALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGL 134 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +LH ++ ++YRDLKL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++ Sbjct: 135 FFLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEII 193 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P++L EA S+ Sbjct: 194 AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICK 253 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEE 441 GL+ K P +RLG G E +++ +H FF I W+ + +++ PPFKP+V+ + FD+ Sbjct: 254 GLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKG-AENFDKF 312 Query: 442 FTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477 FT +TPPDQ + + + F FSY Sbjct: 313 FTRGQPVLTPPDQ----LVIANIDQSDFEGFSYVNP 344 >4L42-A nrPDB Length = 346 Score = 391 bits (1005), Expect = e-109, Method: Composition-based stats. Identities = 154/346 (44%), Positives = 212/346 (61%), Gaps = 10/346 (2%) Query: 135 EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEK---ATGRYYAMKILKKEVIVAK-D 190 E S+ + ++ FE L++LGKG +GKV V++ TG+ +AMK+LKK +IV Sbjct: 5 ETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 64 Query: 191 EVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRA 250 + AHT E +L+ +HPF+ L Y+FQT +L ++EY +GGELF L RE +F ED A Sbjct: 65 DTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTA 124 Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC 310 FY AEI AL +LH +K ++YRDLK EN+ML+ GH+K+TDFGLCKE I DG TFC Sbjct: 125 CFYLAEISMALGHLH-QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 183 Query: 311 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR 370 GT EY+APE+L + + RAVDWW LG +MY+M+ G PF ++ +K + IL ++ P Sbjct: 184 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 243 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 430 L EA+ LL LLK++ RLG G DA E+ H FF I W+ + +K+ PPFKP + Sbjct: 244 YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ 303 Query: 431 SETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476 SE D FD +FT Q +P D + E + F F Y A Sbjct: 304 SEEDVSQFDSKFTRQTPVDSPDD-----STLSEEEQEMFRDFEYIA 344 >2I0E-A nrPDB Length = 353 Score = 387 bits (995), Expect = e-108, Method: Composition-based stats. Identities = 153/337 (45%), Positives = 218/337 (64%), Gaps = 7/337 (2%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + R+ + +F +L +LGKG+FGKV+L + K T YA+KILKK+V++ D+V T+ E RV Sbjct: 14 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 73 Query: 202 LQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 L + PFLT L FQT DRL FVMEY NGG+L +H+ + F E A FY AEI Sbjct: 74 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 133 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE+ Sbjct: 134 LFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 192 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 + YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P+++ EA ++ Sbjct: 193 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 252 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 GL+ K P +RLG G E ++I +H FF I W+ + K++ PP+KP+ FD Sbjct: 253 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRN-AENFDR 311 Query: 441 EFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477 FT +TPPDQ E + + + F FS+ S Sbjct: 312 FFTRHPPVLTPPDQ----EVIRNIDQSEFEGFSFVNS 344 >3TXO-A nrPDB Length = 353 Score = 383 bits (984), Expect = e-107, Method: Composition-based stats. Identities = 155/337 (45%), Positives = 228/337 (67%), Gaps = 7/337 (2%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 +R+ ++ FE++++LGKG+FGKV+L + K TG YA+K+LKK+VI+ D+V T+TE R+L Sbjct: 18 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 77 Query: 203 QNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 +R HPFLT L FQT DRL FVME+ NGG+L FH+ + R F E RARFY AEI+SAL Sbjct: 78 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 137 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +LH +K ++YRDLKL+N++LD +GH K+ DFG+CKEGI +G T TFCGTP+Y+APE+L Sbjct: 138 MFLH-DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 ++ YG AVDWW +GV++YEM+CG PF ++ + LFE IL +E+ +P L +A +L Sbjct: 197 QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILK 256 Query: 382 GLLKKDPKQRLGGGSEDAKE-IMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 + K+P RLG ++ + I++H FF I W + +++ PPF+P++ S D FD Sbjct: 257 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP 316 Query: 441 EFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477 +F + +TP D+ + + F F Y + Sbjct: 317 DFIKEEPVLTPIDE----GHLPMINQDEFRNFEYVSP 349 >5F9E-A nrPDB Length = 353 Score = 378 bits (971), Expect = e-105, Method: Composition-based stats. Identities = 151/348 (43%), Positives = 216/348 (62%), Gaps = 10/348 (2%) Query: 133 EMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV 192 E+ + ++ + +FE K+LGKG+FGKV L + K T +++A+K LKK+V++ D+V Sbjct: 4 ELNKERPSLQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDV 63 Query: 193 AHTLTENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRAR 251 T+ E RVL + HPFLT + +FQT + L FVMEY NGG+L +H+ F RA Sbjct: 64 ECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRAT 123 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG 311 FY AEI+ L +LHS K +VYRDLKL+N++LDKDGHIKI DFG+CKE + A FCG Sbjct: 124 FYAAEIILGLQFLHS-KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCG 182 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRT 371 TP+Y+APE+L Y +VDWW GV++YEM+ G+ PF+ QD E+LF I M+ +PR Sbjct: 183 TPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRW 242 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTS 431 L EAK LL L ++P++RLG +I QH F I W+ + K++ PPF+P+V S Sbjct: 243 LEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKVKS 298 Query: 432 ETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGT 479 D FD+EF + ++ D+ ++S + F FS+ G Sbjct: 299 PFDCSNFDKEFLNEKPRLSFADR----ALINSMDQNMFRNFSFMNPGM 342 >3HDN-A nrPDB Length = 373 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 165/333 (49%), Positives = 221/333 (66%), Gaps = 5/333 (1%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSR 206 ++F +LK++GKG+FGKV+L + KA +YA+K+L+K+ I+ K E H ++E VL +N + Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 97 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HPFL L +SFQT D+L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS Sbjct: 98 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 157 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 N+VYRDLK EN++LD GHI +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y Sbjct: 158 -LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY 216 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 R VDWW LG V+YEM+ G PFY+++ ++++ IL + ++ + A+ LL GLL+K Sbjct: 217 DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQK 276 Query: 387 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQM 446 D +RLG +D EI H FF+ I W + KK++PPF P V+ D R+FD EFT + Sbjct: 277 DRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEP 335 Query: 447 ITITPPDQDDSMECVDS--ERRPHFPQFSYSAS 477 + DS+ S E F FSY+ Sbjct: 336 VPNAIGKAPDSVLVTASVKEAAEAFLGFSYAPP 368 >4OTD-A nrPDB Length = 341 Score = 372 bits (955), Expect = e-103, Method: Composition-based stats. Identities = 155/341 (45%), Positives = 222/341 (65%), Gaps = 8/341 (2%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K +T+ +F++L +LG+G FGKV+L + + +G +A+K LKK IVA+DEV + E R+ Sbjct: 6 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 65 Query: 202 LQNS---RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 L HPFL L FQT + +CFVMEY+ GG+L H+ + VFSE RA FY A +V Sbjct: 66 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVV 124 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 L +LH K +VYRDLKL+NL+LD +G++KI DFGLCKEG+ G TFCGTPE+LAP Sbjct: 125 LGLQFLHEHK-IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378 EVL D Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +E+R+PR L EA Sbjct: 184 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 243 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438 ++ LL+++P++RLG DA+++ + FF + W+ + ++L PPF P ++ TD F Sbjct: 244 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 303 Query: 439 DEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGT 479 DEEFT + T++PP + + + F F + A G Sbjct: 304 DEEFTGEAPTLSPPRDARPLTAAE---QAAFLDFDFVAGGC 341 >4CRS-A nrPDB Length = 341 Score = 371 bits (953), Expect = e-103, Method: Composition-based stats. Identities = 157/346 (45%), Positives = 222/346 (64%), Gaps = 8/346 (2%) Query: 137 SLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 196 S+++ + + + +F +L +G FGKV+L + K T +A+K LKK IVA+DEV + Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 60 Query: 197 TENRVLQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253 E R+ + + RHPFL L FQT + +CFVMEYA GG+L H+ + VFSE RA FY Sbjct: 61 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFY 119 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP 313 A +V L YLH K +VYRDLKL+NL+LD +G +KI DFGLCKEG+ G TFCGTP Sbjct: 120 AACVVLGLQYLHEHK-IVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP 178 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLG 373 E+LAPEVL + Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +E+R+PR L Sbjct: 179 EFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS 238 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSET 433 EA S++ LL+++P++RLG +DA+++ +H FF I W + +KK+ PPF P + Sbjct: 239 TEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGRE 298 Query: 434 DTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGT 479 D FD+EFT++ +TPP + + E + F F Y A Sbjct: 299 DVSNFDDEFTSEAPILTPPREPRI---LSEEEQEMFRDFDYIADWC 341 >5D9K-A nrPDB Length = 330 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 137/309 (44%), Positives = 199/309 (64%), Gaps = 5/309 (1%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEK---ATGRYYAMKILKKEVIVAKDEVAHTLTE 198 + ++FE LK+LG+G+FGKV LVK+ + YAMK+LKK + +D V T E Sbjct: 24 HEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRV-RTKME 82 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 +L HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ Sbjct: 83 RDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 ALD+LHS ++YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+AP Sbjct: 143 LALDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAP 201 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378 EV+ + ++ DWW GV+M+EM+ G LPF +D ++ +IL ++ P+ L PEA+S Sbjct: 202 EVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQS 261 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438 LL L K++P RLG G + +EI +H FF+ I W +Y +++ PPFKP DT YF Sbjct: 262 LLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYF 321 Query: 439 DEEFTAQMI 447 D EFTA+ Sbjct: 322 DPEFTAKTP 330 >3A8W-A nrPDB Length = 345 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 155/346 (44%), Positives = 222/346 (64%), Gaps = 16/346 (4%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++ +++ TE V Sbjct: 4 DPLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVF 63 Query: 203 QN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 + S HPFL L FQT RL FV+EY NGG+L FH+ R+R E+ ARFY AEI AL Sbjct: 64 EQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLAL 123 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +YLH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T TFCGTP Y+APE+L Sbjct: 124 NYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 182 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPF--------YNQDHEK-LFELILMEEIRFPRTL 372 DYG +VDWW LGV+M+EMM GR PF +Q+ E LF++IL ++IR PR+L Sbjct: 183 RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSL 242 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSED-AKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTS 431 +A S+L L KDPK+RLG + +I H FF + W + +K++ PPFKP ++ Sbjct: 243 SVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISG 302 Query: 432 ETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477 E FD +FT + + +TP D D V + F F Y Sbjct: 303 EFGLDNFDSQFTNEPVQLTPDDDD----IVRKIDQSEFEGFEYINP 344 >2Z7Q-A nrPDB Length = 321 Score = 358 bits (918), Expect = 4e-99, Method: Composition-based stats. Identities = 133/300 (44%), Positives = 194/300 (64%), Gaps = 5/300 (1%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEK---ATGRYYAMKILKKEVIVAKDEVAHTLTEN 199 + + FE LK+LG+G+FGKV LV++ +G YAMK+LKK + +D V T E Sbjct: 23 EKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMER 81 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 +L + HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ Sbjct: 82 DILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 141 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 LD+LHS ++YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APE Sbjct: 142 GLDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 200 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379 V+ + + DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA+SL Sbjct: 201 VVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSL 260 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439 L L K++P RLG G + A+EI +H F++ I W +Y +++ PPFKP V DT YFD Sbjct: 261 LRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 320 >5N23-A nrPDB Length = 352 Score = 350 bits (899), Expect = 6e-97, Method: Composition-based stats. Identities = 137/337 (40%), Positives = 196/337 (58%), Gaps = 10/337 (2%) Query: 105 TVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVT-MNEFEYLKLLGKGTFGK 163 A ++E +F + + D E P +++FE ++ LG G+FG+ Sbjct: 4 AAAAKKGSEQESVKEFLAKAKEDFLKKWE------SPAQNTAHLDQFERIRTLGTGSFGR 57 Query: 164 VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223 V+LVK K TG +YAMKIL K+ +V ++ HTL E R+ Q PFL L++SF+ + L Sbjct: 58 VMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNL 117 Query: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283 V+EYA GGE+F HL R FSE ARFY A+IV +YLHS +++YRDLK ENL++D Sbjct: 118 YMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLID 176 Query: 284 KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 343 + G+IK+ DFG K G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM Sbjct: 177 QQGYIKVADFGFAKRV--KGRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA 234 Query: 344 CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403 G PF+ +++E I+ ++RFP + K LL LL+ D +R G +I Sbjct: 235 AGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIK 294 Query: 404 QHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 295 NHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 331 >4RLP-A nrPDB Length = 288 Score = 348 bits (894), Expect = 2e-96, Method: Composition-based stats. Identities = 137/288 (47%), Positives = 188/288 (65%), Gaps = 5/288 (1%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEK---ATGRYYAMKILKKEVIVAK-DEVAHTLTEN 199 ++ FE L++LGKG +GKV V++ TG+ +AMK+LKK +IV + AHT E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 +L+ +HPF+ L Y+FQT +L ++EY +GGELF L RE +F ED A FY AEI Sbjct: 61 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 120 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 AL +LH +K ++YRDLK EN+ML+ GH+K+TDFGLCKE I DG TFCGT EY+APE Sbjct: 121 ALGHLH-QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 179 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379 +L + + RAVDWW LG +MY+M+ G PF ++ +K + IL ++ P L EA+ L Sbjct: 180 ILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDL 239 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427 L LLK++ RLG G DA E+ H FF I W+ + +K+ PPFKP Sbjct: 240 LKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >4WB7-A nrPDB Length = 405 Score = 348 bits (892), Expect = 4e-96, Method: Composition-based stats. Identities = 143/357 (40%), Positives = 205/357 (57%), Gaps = 17/357 (4%) Query: 91 ETPEER-EEWTTAIQTVADGLKKQ-----EEEEMDFRSGSPSDNSGAEEMEVSLAKPKHR 144 EE+ +E A ++D K++ EE +F + + D E P Sbjct: 38 PGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEVKEFLAKAKEDFLKKWE------SPAQN 91 Query: 145 VT-MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +++FE +K LG G+FG+V+LVK K TG +YAMKIL K+ +V ++ HTL E R+LQ Sbjct: 92 TAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQ 151 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 PFL L++SF+ + L VMEY GGE+F HL R FSE ARFY A+IV +Y Sbjct: 152 AVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEY 211 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LHS +++YRDLK ENL++D+ G+I++TDFG K T CGTPEYLAPE++ Sbjct: 212 LHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILS 267 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 Y +AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL L Sbjct: 268 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 327 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 L+ D +R G +I H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 328 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 384 >5X3F-B nrPDB Length = 393 Score = 348 bits (892), Expect = 4e-96, Method: Composition-based stats. Identities = 129/295 (43%), Positives = 184/295 (62%), Gaps = 4/295 (1%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +++F+ +K LG G+FG+V+LVK K +G +YAMKIL K+ +V ++ HTL E R+LQ Sbjct: 82 QLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 141 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 PFL L++SF+ + L VMEY GGE+F HL R FSE ARFY A+IV +YLH Sbjct: 142 NFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 201 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 S +++YRDLK ENL++D+ G+I++TDFG K T CGTPEYLAPE++ Sbjct: 202 S-LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKG 257 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 Y +AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL LL+ Sbjct: 258 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQ 317 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 D +R G +I H++FA W +Y++K+ PF P+ DT FD+ Sbjct: 318 VDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 372 >1FOT-A nrPDB Length = 318 Score = 346 bits (889), Expect = 8e-96, Method: Composition-based stats. Identities = 126/316 (39%), Positives = 191/316 (60%), Gaps = 8/316 (2%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 + ++ +F+ L+ LG G+FG+V L++ + GRYYAMK+LKKE++V +V HT E +L Sbjct: 2 KYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLS 61 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 HPF+ + +FQ ++ +M+Y GGELF L + + F A+FY AE+ AL+Y Sbjct: 62 IVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 121 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LHS K+++YRDLK EN++LDK+GHIKITDFG K T CGTP+Y+APEV+ Sbjct: 122 LHS-KDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD---VTYTLCGTPDYIAPEVVST 177 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 Y +++DWW G+++YEM+ G PFY+ + K +E IL E+RFP + K LLS L Sbjct: 178 KPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRL 237 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV-TSETDTRYFD--- 439 + +D QRLG +++ H +F +VW+ + + + P++P + + DT FD Sbjct: 238 ITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYP 297 Query: 440 EEFTAQMITITPPDQD 455 EE + P D Sbjct: 298 EEDINYGVQGEDPYAD 313 >1VZO-A nrPDB Length = 355 Score = 331 bits (850), Expect = 3e-91, Method: Composition-based stats. Identities = 138/315 (43%), Positives = 191/315 (60%), Gaps = 13/315 (4%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEV 192 +L +V + FE LK+LG G +GKV LV++ TG+ YAMK+LKK IV K + Sbjct: 42 ANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKT 101 Query: 193 -AHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRA 250 HT TE +VL++ R PFL L Y+FQT +L +++Y NGGELF HLS+ F+E Sbjct: 102 TEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEV 161 Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD-GATMKTF 309 + Y EIV AL++LH + ++YRD+KLEN++LD +GH+ +TDFGL KE + D F Sbjct: 162 QIYVGEIVLALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDF 220 Query: 310 CGTPEYLAPEVLEDN--DYGRAVDWWGLGVVMYEMMCGRLPF----YNQDHEKLFELILM 363 CGT EY+AP+++ + +AVDWW LGV+MYE++ G PF ++ IL Sbjct: 221 CGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILK 280 Query: 364 EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSP 423 E +P+ + AK L+ LL KDPK+RLG G DA EI +H FF I W + KK+ Sbjct: 281 SEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPA 340 Query: 424 PFKPQVTSETDTRYF 438 PFKP + E D F Sbjct: 341 PFKPVIRDELDVSNF 355 >6BDL-A nrPDB Length = 347 Score = 321 bits (823), Expect = 4e-88, Method: Composition-based stats. Identities = 118/314 (37%), Positives = 175/314 (55%), Gaps = 7/314 (2%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEK-ATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + +++F + LG G FG+V LV+ K + +AMKILKK IV + H +E +++ Sbjct: 30 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 89 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 Q + F+ L +F+ L +ME GGEL+ L F + RFY A +V A Sbjct: 90 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 149 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 YLHS K ++YRDLK ENL+LD G+ K+ DFG K+ I G TFCGTPEY+APE++ Sbjct: 150 YLHS-KGIIYRDLKPENLILDHRGYAKLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIIL 207 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME--EIRFPRTLGPEAKSLL 380 + + + D+W LG++MYE++ G PF D K + +IL I FP+ + A +L+ Sbjct: 208 NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLI 267 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 L + +P +RLG K+I +H++F G W+ + + L+PP P V S TDT FD Sbjct: 268 KKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDS 327 Query: 441 EFTAQMITITPPDQ 454 + PPD Sbjct: 328 F--PEDNDEPPPDD 339 >3TKU-A nrPDB Length = 433 Score = 321 bits (822), Expect = 6e-88, Method: Composition-based stats. Identities = 123/349 (35%), Positives = 191/349 (54%), Gaps = 23/349 (6%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 ++ +FE +K++G+G FG+V +VK K T R YAMKIL K ++ + E A E VL Sbjct: 86 QLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV 145 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALD 262 N ++TAL Y+FQ + L VM+Y GG+L LS+ E ED ARFY E+V A+D Sbjct: 146 NGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAID 205 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF-CGTPEYLAPEVL 321 +H + + V+RD+K +N++LD +GHI++ DFG C + DG + GTP+Y++PE+L Sbjct: 206 SIH-QLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEIL 264 Query: 322 ED-----NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFPRT--- 371 + YG DWW LGV MYEM+ G PFY + + + I+ E +FP Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTD 324 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTS 431 + EAK L+ L+ ++RLG ++ +H FF G+ W+++ + L P+ P V+S Sbjct: 325 VSEEAKDLIQRLIC-SRERRLGQ--NGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSS 379 Query: 432 ETDTRYFD-EEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGT 479 +DT FD ++ + I PP + F F+++ Sbjct: 380 PSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLP----FIGFTFTTESC 424 >5FET-A nrPDB Length = 847 Score = 319 bits (817), Expect = 2e-87, Method: Composition-based stats. Identities = 113/323 (34%), Positives = 178/323 (55%), Gaps = 12/323 (3%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +V M+E E +++G+GTFG V LV K T YA+K + K I++ ++ + E + Sbjct: 529 KVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITA 588 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + HPF+ L +F+ + F+ E GGEL+ + + + S+ +A+FY I+ A++Y Sbjct: 589 ENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEY 648 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LH E+N+VYRDLK EN++LDK G++K+ DFG K+ T GTP Y+APEV+ Sbjct: 649 LH-ERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI---QGRAYTLVGTPHYMAPEVILG 704 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYN--QDHEKLFELILMEEIRFPRTLG-PEAKSLL 380 YG VD W LGV +YE +CG LPF N +D ++F IL ++ FP + ++ +L+ Sbjct: 705 KGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLM 764 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ---VTSETDTRY 437 LL + P+ R+G K+I +H FF W + + L PP + + D + Sbjct: 765 KRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQ 824 Query: 438 FDEEFTAQMITITPPDQDDSMEC 460 +EE + P D DDS + Sbjct: 825 IEEED--ALNEGEPLDGDDSWDV 845 >4AW2-A nrPDB Length = 437 Score = 318 bits (814), Expect = 5e-87, Method: Composition-based stats. Identities = 123/349 (35%), Positives = 192/349 (55%), Gaps = 25/349 (7%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ +FE LK++G+G FG+V +VK K + +AMKIL K ++ + E A E VL Sbjct: 70 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV 129 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALD 262 N ++T L Y+FQ + L VM+Y GG+L LS+ E E+ ARFY AE+V A+D Sbjct: 130 NGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAID 189 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF-CGTPEYLAPEVL 321 +H + + V+RD+K +N+++D +GHI++ DFG C + ++DG + GTP+Y++PE+L Sbjct: 190 SVH-QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 248 Query: 322 E-----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFP---RT 371 + YG DWW LGV MYEM+ G PFY + + + I+ E +FP Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTD 308 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTS 431 + AK L+ L+ + RLG ++ +H FF+GI W ++ + P+ P+V+S Sbjct: 309 VSENAKDLIRRLIC-SREHRLGQ--NGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSS 363 Query: 432 ETDTRYF--DEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478 TDT F D++ T+ PP S F F+Y++S Sbjct: 364 PTDTSNFDVDDDCLKNSETMPPPTHTAF-----SGHHLPFVGFTYTSSC 407 >5LOH-A nrPDB Length = 341 Score = 316 bits (809), Expect = 2e-86, Method: Composition-based stats. Identities = 126/346 (36%), Positives = 194/346 (56%), Gaps = 23/346 (6%) Query: 117 EMDFRSGS---PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATG 173 MD +GS P + EE +A PK ++ EF +K + +G FGKV L ++ G Sbjct: 3 HMDPTAGSKKEPGGGAATEEGVNRIAVPK-PPSIEEFSIVKPISRGAFGKVYLGQKG--G 59 Query: 174 RYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGG 233 + YA+K++KK ++ K+ E L S+ PF+ L YS Q+ + + VMEY GG Sbjct: 60 KLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGG 119 Query: 234 ELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF 293 ++ L F E+ A Y +E+ ALDYLH +++RDLK +N+++ +GHIK+TDF Sbjct: 120 DVKSLLHIYGYFDEEMAVKYISEVALALDYLH-RHGIIHRDLKPDNMLISNEGHIKLTDF 178 Query: 294 GLCKEG------IKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347 GL K + D T +TFCGTP+YLAPE+L +G AVDWW LGV ++E + G Sbjct: 179 GLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIP 238 Query: 348 PFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 PF ++ +++F+ IL +I +P L A+S + LL D +R KE+ + Sbjct: 239 PFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKR-----AGMKELKR 293 Query: 405 HRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITIT 450 H F+ + W+++ + + PF PQ ETDT YF+ TAQ +T++ Sbjct: 294 HPLFSDVDWENLQHQTM--PFIPQPDDETDTSYFEARNTAQHLTVS 337 >3NYO-A nrPDB Length = 576 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 122/322 (37%), Positives = 182/322 (56%), Gaps = 10/322 (3%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E ++ Sbjct: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER--VFSEDRARFYGAEIVS 259 L+ F+ +L Y+++T D LC V+ NGG+L FH+ F E RA FY AEI Sbjct: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 L+ LH E+ +VYRDLK EN++LD GHI+I+D GL + +G T+K GT Y+APE Sbjct: 298 GLEDLHRER-IVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPE 355 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPE 375 V+++ Y + DWW LG ++YEM+ G+ PF + E++ L+ + P+ Sbjct: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK--PQVTSET 433 A+SL S LL KDP +RLG A+E+ +H F + ++ + L PPFK PQ Sbjct: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCK 475 Query: 434 DTRYFDEEFTAQMITITPPDQD 455 D ++ T + + + P DQD Sbjct: 476 DVLDIEQFSTVKGVELEPTDQD 497 >6E9W-A nrPDB Length = 443 Score = 311 bits (797), Expect = 4e-85, Method: Composition-based stats. Identities = 116/342 (33%), Positives = 178/342 (52%), Gaps = 21/342 (6%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ ++E +K++G+G FG+V LV+ K+T + YAMK+L K ++ + + A E ++ Sbjct: 98 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 157 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + P++ L Y+FQ L VMEY GG+L +S V E ARFY AE+V ALD Sbjct: 158 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAEVVLALDA 216 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA-TMKTFCGTPEYLAPEVLE 322 +HS ++RD+K +N++LDK GH+K+ DFG C + K+G T GTP+Y++PEVL+ Sbjct: 217 IHS-MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 323 DND----YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE--IRFPR--TLGP 374 YGR DWW +GV +YEM+ G PFY + I+ + + FP + Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISK 335 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETD 434 EAK+L+ L D + RLG +EI +H FF W + P P ++S+ D Sbjct: 336 EAKNLICAFLT-DREVRLGR--NGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDID 392 Query: 435 TRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476 T FD+ + T P + P ++ Sbjct: 393 TSNFDDLEEDKGEEETFP-------IPKAFVGNQLPFVGFTY 427 >2VD5-A nrPDB Length = 412 Score = 310 bits (794), Expect = 9e-85, Method: Composition-based stats. Identities = 127/353 (35%), Positives = 181/353 (51%), Gaps = 24/353 (6%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ ++FE LK++G+G F +V +VK K TG+ YAMKI+ K ++ + EV+ E VL Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 116 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALD 262 N ++T L ++FQ + L VMEY GG+L LS+ + ARFY AEIV A+D Sbjct: 117 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 176 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK-TFCGTPEYLAPEVL 321 +H V+RD+K +N++LD+ GHI++ DFG C + DG GTP+YL+PE+L Sbjct: 177 SVH-RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 235 Query: 322 E-------DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFP--- 369 + YG DWW LGV YEM G+ PFY + + I+ E + P Sbjct: 236 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 295 Query: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV 429 + EA+ + LL P+ RLG G A + H FF G+ W + + PPF P Sbjct: 296 EGVPEEARDFIQRLLCP-PETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDF 350 Query: 430 TSETDTRYFD--EEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480 TDT FD E+ M++ D E + H P YS S A Sbjct: 351 EGATDTCNFDLVEDGLTAMVSGGGETLSDIRE--GAPLGVHLPFVGYSYSCMA 401 >5YKS-A nrPDB Length = 377 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 92/323 (28%), Positives = 163/323 (50%), Gaps = 16/323 (4%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 ++ K LG+G F V L + TG A+K++ K + H E R ++ +HP Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLA-TGHLFQEVRCMKLVQHPN 95 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYLHSEK 268 + L T +L ++E +GG++F ++ + +ED A+ Y A+IV A+ Y H + Sbjct: 96 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH-KL 154 Query: 269 NVVYRDLKLENL-MLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +VV+RDLK EN+ +K G +K+TDFG + + G + T CG+ Y APE+L ++Y Sbjct: 155 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNK-FQPGKKLTTSCGSLAYSAPEILLGDEYD 213 Query: 328 -RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 AVD W LGV+++ ++CG+ PF + + +I+ + P + E K L++ +L++ Sbjct: 214 APAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQR 273 Query: 387 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQM 446 DPK+R +EI H + G+ + P V+ + + +M Sbjct: 274 DPKRR-----ASLEEIENHPWLQGVD-----PSPATKYNIPLVSYKNLSEEEHNSIIQRM 323 Query: 447 ITITPPDQDDSMECVDSERRPHF 469 + D+D +E +++ R H Sbjct: 324 VLGDIADRDAIVEALETNRYNHI 346 >5DYK-A nrPDB Length = 853 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 104/288 (36%), Positives = 163/288 (56%), Gaps = 7/288 (2%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +V M+E E +++G+GTFG V LV K T YA+K + K I+ ++ + E + Sbjct: 535 KVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITA 594 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + HPF+ L +F+ F+ E GGEL+ + + + S+ +A+FY I+ A++Y Sbjct: 595 ENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEY 654 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 LH E+N+VYRDLK EN++LDK G++K+ DFG K+ T GTP Y+APEV+ Sbjct: 655 LH-ERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV---QGRAYTLVGTPHYMAPEVILG 710 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYN--QDHEKLFELILMEEIRFPRTLGP-EAKSLL 380 YG VD W LG+ +YE +CG LPF N +D ++F IL ++ FP + ++ +L+ Sbjct: 711 KGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLM 770 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428 LL + P+ R+G K+I H FF+ W + + L PP + Sbjct: 771 KRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSK 818 >6ED6-A nrPDB Length = 415 Score = 307 bits (786), Expect = 8e-84, Method: Composition-based stats. Identities = 110/318 (34%), Positives = 175/318 (55%), Gaps = 14/318 (4%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 ++ +++ +K++G+G FG+V LV+ KA+ + YAMK+L K ++ + + A E ++ Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 143 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + P++ L Y+FQ L VMEY GG+L +S V E A+FY AE+V ALD Sbjct: 144 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVVLALDA 202 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM-KTFCGTPEYLAPEVLE 322 +HS +++RD+K +N++LDK GH+K+ DFG C + + G T GTP+Y++PEVL+ Sbjct: 203 IHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 323 DND----YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--MEEIRFPRT--LGP 374 YGR DWW +GV +YEM+ G PFY + I+ + FP + Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISK 321 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETD 434 AK+L+ L D + RLG +EI QH FF W ++ + P P+++S+ D Sbjct: 322 HAKNLICAFLT-DREVRLGR--NGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDID 378 Query: 435 TRYFDEEFTAQMITITPP 452 + FD+ + T P Sbjct: 379 SSNFDDIEDDKGDVETFP 396 >5ES1-A nrPDB Length = 328 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 101/329 (30%), Positives = 167/329 (50%), Gaps = 20/329 (6%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 P+ + + + L+ +GKG F KV L + TGR A+KI+ K + + E R Sbjct: 8 PEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLFREVR 66 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 +++ HP + L +T L VMEYA+ GE+F +L E AR +IVSA Sbjct: 67 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSA 126 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 + Y H +KN+V+RDLK ENL+LD + +IKI DFG E G+ + TFCG+P Y APE+ Sbjct: 127 VHYCH-QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFT-LGSKLDTFCGSPPYAAPEL 184 Query: 321 LEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379 + Y G VD W LGV++Y ++ G LPF + ++L E +L + R P + + +S+ Sbjct: 185 FQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESI 244 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439 L L +P +R ++IM+ ++ ++L P +P+ F Sbjct: 245 LRRFLVLNPAKRC-----TLEQIMKDKWIN----IGYEGEELKPYTEPE-------EDFG 288 Query: 440 EEFTAQMITITPPDQDDSMECVDSERRPH 468 + +++ +++ E + S++ Sbjct: 289 DTKRIEVMVGMGYTREEIKESLTSQKYNE 317 >4TNB-A nrPDB Length = 590 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 122/322 (37%), Positives = 180/322 (55%), Gaps = 10/322 (3%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + + L E ++ Sbjct: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI 237 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVS 259 L+ F+ L Y+++T D LC V+ NGG+L FH+ F E+RA FY AEI+ Sbjct: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 L+ LH E N VYRDLK EN++LD GHI+I+D GL + I +G ++ GT Y+APE Sbjct: 298 GLEDLHHE-NTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPE 355 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPE 375 VL + YG + D+WGLG ++YEM+ G+ PF + E++ +L E + E Sbjct: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEE 415 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT--SET 433 AKS+ LL KD KQRLG E+A E+ +H FF + ++ + L PPF P Sbjct: 416 AKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCK 475 Query: 434 DTRYFDEEFTAQMITITPPDQD 455 D ++ T + + + D D Sbjct: 476 DVLDIEQFSTVKGVNLDHTDDD 497 >5KZ7-A nrPDB Length = 346 Score = 304 bits (779), Expect = 5e-83, Method: Composition-based stats. Identities = 102/302 (33%), Positives = 153/302 (50%), Gaps = 11/302 (3%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 S + + + LK +GKG F KV L + TG+ A+KI+ K + + + Sbjct: 21 NSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS-LQKL 79 Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 E R+++ HP + L +T L VMEYA+GGE+F +L E AR Sbjct: 80 FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 139 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEY 315 +IVSA+ Y H +K +V+RDLK ENL+LD D +IKI DFG E G + TFCG+P Y Sbjct: 140 QIVSAVQYCH-QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT-FGNKLDTFCGSPPY 197 Query: 316 LAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGP 374 APE+ + Y G VD W LGV++Y ++ G LPF Q+ ++L E +L + R P + Sbjct: 198 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMST 257 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETD 434 + ++LL L +P +R ++IM+ R+ + + K P P Sbjct: 258 DCENLLKKFLILNPSKR-----GTLEQIMKDRWM-NVGHEDDELKPYVEP-LPDYKDPRR 310 Query: 435 TR 436 T Sbjct: 311 TE 312 >2QNJ-A nrPDB Length = 328 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 105/328 (32%), Positives = 165/328 (50%), Gaps = 20/328 (6%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + + + LK +GKG F KV L + TGR A+KI+ K + + E R++ Sbjct: 7 EQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTS-LQKLFREVRIM 65 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + HP + L +T L +MEYA+GGE+F +L E AR +IVSA+ Sbjct: 66 KILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQ 125 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 Y H +K +V+RDLK ENL+LD D +IKI DFG E G + TFCG+P Y APE+ + Sbjct: 126 YCH-QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFT-VGGKLDTFCGSPPYAAPELFQ 183 Query: 323 DNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 Y G VD W LGV++Y ++ G LPF Q+ ++L E +L + R P + + ++LL Sbjct: 184 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 243 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEE 441 L +P +R ++IM+ R+ E +L P +P++ +D + D Sbjct: 244 RFLVLNPIKR-----GTLEQIMKDRWIN----AGHEEDELKPFVEPEL-DISDQKRID-- 291 Query: 442 FTAQMITITPPDQDDSMECVDSERRPHF 469 ++ Q++ E + + Sbjct: 292 ----IMVGMGYSQEEIQESLSKMKYDEI 315 >3HZT-A nrPDB Length = 467 Score = 301 bits (770), Expect = 6e-82, Method: Composition-based stats. Identities = 91/268 (33%), Positives = 136/268 (50%), Gaps = 15/268 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ +K LG G +G+V+L K+K TG A+KI+KK + L E VL+ H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L F+ VME GGELF + + FSE A +++S YLH + Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH-K 122 Query: 268 KNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 N+V+RDLK ENL+L +D IKI DFGL + G MK GT Y+APEVL Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLS-AHFEVGGKMKERLGTAYYIAPEVLR-K 180 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRT----LGPEAKSLL 380 Y D W GV++Y ++CG PF Q +++ + + + F + EAK L+ Sbjct: 181 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 240 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +L +P +R+ A+E + H + Sbjct: 241 KLMLTYEPSKRIS-----AEEALNHPWI 263 >3DXN-A nrPDB Length = 287 Score = 300 bits (769), Expect = 8e-82, Method: Composition-based stats. Identities = 91/268 (33%), Positives = 136/268 (50%), Gaps = 15/268 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ +K LG G +G+V+L K+K TG A+KI+KK + L E VL+ H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L F+ VME GGELF + + FSE A +++S YLH + Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH-K 139 Query: 268 KNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 N+V+RDLK ENL+L +D IKI DFGL + G MK GT Y+APEVL Sbjct: 140 HNIVHRDLKPENLLLESKSRDALIKIVDFGLS-AHFEVGGKMKERLGTAYYIAPEVLR-K 197 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRT----LGPEAKSLL 380 Y D W GV++Y ++CG PF Q +++ + + + F + EAK L+ Sbjct: 198 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLV 257 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +L +P +R+ A+E + H + Sbjct: 258 KLMLTYEPSKRIS-----AEEALNHPWI 280 >2VN9-A nrPDB Length = 301 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 87/268 (32%), Positives = 138/268 (51%), Gaps = 14/268 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +E++ + LGKG F V + TG+ YA KI+ + + A+D E R+ + +H Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH-QKLEREARICRLLKH 62 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L S V + GGELF + +SE A +I+ ++++ H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH-L 121 Query: 268 KNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 +V+RDLK ENL+L K +K+ DFGL E D F GTP YL+PEVL + Sbjct: 122 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 181 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 YG+ VD W GV++Y ++ G PF+++D +L++ I FP T+ PEAK L+ Sbjct: 182 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 241 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + +L +P +R+ A E ++H + Sbjct: 242 NKMLTINPAKRI-----TASEALKHPWI 264 >4REW-A nrPDB Length = 540 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 105/322 (32%), Positives = 156/322 (48%), Gaps = 26/322 (8%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 V + + LG GTFGKV + K + TG A+KIL ++ I + D V E + L+ Sbjct: 3 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 62 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 RHP + L T + VMEY +GGELF ++ + E +R +I+S +DY Sbjct: 63 FRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYC 122 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y APEV+ Sbjct: 123 HRHM-VVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGR 180 Query: 325 DY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 Y G VD W GV++Y ++CG LPF + LF+ I P+ L P SLL + Sbjct: 181 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 240 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY----FD 439 L+ DP +R K+I +H +F P+ D Y D Sbjct: 241 LQVDPMKR-----ASIKDIREHEWFKQ--------------DLPKYLFPEDPSYSSTMID 281 Query: 440 EEFTAQMITITPPDQDDSMECV 461 +E ++ +++ + C+ Sbjct: 282 DEALKEVCEKFECSEEEVLSCL 303 >4MVF-A nrPDB Length = 506 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 96/339 (28%), Positives = 159/339 (46%), Gaps = 26/339 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +++ + LG+GT+G V +K T + YA+K KK+ + + E +++ H Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRL---KNINRFFQEIEIMKKLDH 113 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L +++ + + +ME +G ELF + F+E A +I SA+ YLHS Sbjct: 114 PNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS- 172 Query: 268 KNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 N+V+RDLK EN + +KD +KI DFGL K + G T GTP Y+AP+VL D Sbjct: 173 LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKN-LGTGEFTTTKAGTPYYVAPQVL-DG 230 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRT----LGPEAKSLL 380 Y + D W GV+MY ++CG PFY ++ + + E F + +AK+L+ Sbjct: 231 KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLI 290 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 + LL +P +R +E + H + + H + + S K + + F + Sbjct: 291 TKLLTYNPNERC-----TIEEALNHPWITQMTKSHEHVELSSTLLK-------NLKNFKK 338 Query: 441 EFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGT 479 E + I +T + + R F SGT Sbjct: 339 ENELKKIALTII-AKHLCDVEINNLRNIFIALDVDNSGT 376 >3MN3-A nrPDB Length = 271 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 100/264 (37%), Positives = 147/264 (55%), Gaps = 9/264 (3%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + ++ +K LG+G+FGKV L TG+ A+KI+ K+V+ D E L+ R Sbjct: 3 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR 62 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L ++ D + V+EYA G ELF ++ + SE AR + +I+SA++Y H Sbjct: 63 HPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 K +V+RDLK ENL+LD+ ++KI DFGL + DG +KT CG+P Y APEV+ Y Sbjct: 122 HK-IVHRDLKPENLLLDEHLNVKIADFGLS-NIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 327 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 G VD W GV++Y M+C RLPF ++ LF+ I P+ L P A L+ +L Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLI 239 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFA 409 +P R+ EIMQ +F Sbjct: 240 VNPLNRIS-----IHEIMQDDWFK 258 >5FG8-A nrPDB Length = 285 Score = 298 bits (764), Expect = 3e-81, Method: Composition-based stats. Identities = 86/268 (32%), Positives = 140/268 (52%), Gaps = 14/268 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ + LGKG F V +K+TG +A KI+ + + A+D E R+ + H Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARD-FQKLEREARICRKLHH 72 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L S Q + V + GGELF + +SE A +I+ ++++ H + Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH-Q 131 Query: 268 KNVVYRDLKLENLMLDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 VV+RDLK ENL+L +K+ DFGL E D F GTP YL+PEVL+ Sbjct: 132 NGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKE 191 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 YG++VD W GV++Y ++ G PF+++D +L+ I +P T+ PEAK+L+ Sbjct: 192 PYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLI 251 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + +L +P +R+ A E ++H + Sbjct: 252 NQMLTVNPNKRI-----TAAEALKHPWI 274 >4CFF-A nrPDB Length = 571 Score = 298 bits (764), Expect = 3e-81, Method: Composition-based stats. Identities = 105/303 (34%), Positives = 152/303 (50%), Gaps = 18/303 (5%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 RV + + LG GTFGKV + + + TG A+KIL ++ I + D V E + L+ Sbjct: 29 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 88 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 RHP + L T VMEY +GGELF ++ + E AR +I+SA+DY Sbjct: 89 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 148 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y APEV+ Sbjct: 149 CHRHM-VVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 324 NDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 Y G VD W GV++Y ++CG LPF ++ LF+ I P L +LL Sbjct: 207 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 266 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442 +L+ DP +R K+I +H +F ++ L P+ S D D+E Sbjct: 267 MLQVDPLKR-----ATIKDIREHEWF---------KQDLPSYLFPEDPSY-DANVIDDEA 311 Query: 443 TAQ 445 + Sbjct: 312 VKE 314 >5UUU-A nrPDB Length = 547 Score = 298 bits (764), Expect = 3e-81, Method: Composition-based stats. Identities = 117/324 (36%), Positives = 180/324 (55%), Gaps = 16/324 (4%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L Sbjct: 194 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 253 Query: 204 NS---RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI+ Sbjct: 254 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 L+++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+APEV Sbjct: 314 LEHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPEV 370 Query: 321 LE-DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEEIRFPRTLGPEA 376 L+ Y + DW+ LG ++++++ G PF D ++ + L + P + PE Sbjct: 371 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 430 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTS 431 +SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P Sbjct: 431 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAAD 490 Query: 432 ETDTRYFDEEFTAQMITITPPDQD 455 D FDEE T + I + DQ+ Sbjct: 491 AFDIGSFDEEDT-KGIKLLDSDQE 513 >5EZV-A nrPDB Length = 560 Score = 298 bits (762), Expect = 4e-81, Method: Composition-based stats. Identities = 108/312 (34%), Positives = 155/312 (49%), Gaps = 20/312 (6%) Query: 137 SLAKPKH--RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH 194 K KH RV + + LG GTFGKV + + + TG A+KIL ++ I + D V Sbjct: 15 PAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 74 Query: 195 TLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYG 254 E + L+ RHP + L T VMEY +GGELF ++ + E AR Sbjct: 75 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 134 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE 314 +I+SA+DY H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Sbjct: 135 QQILSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPN 192 Query: 315 YLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLG 373 Y APEV+ Y G VD W GV++Y ++CG LPF ++ LF+ I P L Sbjct: 193 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 252 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSET 433 +LL +L+ DP +R K+I +H +F ++ L P+ S Sbjct: 253 RSVATLLMHMLQVDPLKR-----ATIKDIREHEWF---------KQDLPSYLFPEDPSY- 297 Query: 434 DTRYFDEEFTAQ 445 D D+E + Sbjct: 298 DANVIDDEAVKE 309 >3PVW-A nrPDB Length = 695 Score = 298 bits (762), Expect = 5e-81, Method: Composition-based stats. Identities = 117/324 (36%), Positives = 180/324 (55%), Gaps = 16/324 (4%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 +TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L Sbjct: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 Query: 204 NS---RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI+ Sbjct: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 L+++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+APEV Sbjct: 305 LEHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPEV 361 Query: 321 LE-DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEEIRFPRTLGPEA 376 L+ Y + DW+ LG ++++++ G PF D ++ + L + P + PE Sbjct: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTS 431 +SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P Sbjct: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAAD 481 Query: 432 ETDTRYFDEEFTAQMITITPPDQD 455 D FDEE T + I + DQ+ Sbjct: 482 AFDIGSFDEEDT-KGIKLLDSDQE 504 >4RED-A nrPDB Length = 351 Score = 297 bits (760), Expect = 8e-81, Method: Composition-based stats. Identities = 105/322 (32%), Positives = 156/322 (48%), Gaps = 26/322 (8%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 V + + LG GTFGKV + K + TG A+KIL ++ I + D V E + L+ Sbjct: 11 VKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKL 70 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 RHP + L T + VMEY +GGELF ++ + E +R +I+S +DY Sbjct: 71 FRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYC 130 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y APEV+ Sbjct: 131 HRHM-VVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGR 188 Query: 325 DY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 Y G VD W GV++Y ++CG LPF + LF+ I P+ L P SLL + Sbjct: 189 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 248 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY----FD 439 L+ DP +R K+I +H +F P+ D Y D Sbjct: 249 LQVDPMKR-----ASIKDIREHEWFKQ--------------DLPKYLFPEDPSYSTTMID 289 Query: 440 EEFTAQMITITPPDQDDSMECV 461 +E ++ +++ + C+ Sbjct: 290 DEALKEVCEKFECSEEEVLSCL 311 >5JN2-A nrPDB Length = 525 Score = 297 bits (760), Expect = 8e-81, Method: Composition-based stats. Identities = 84/276 (30%), Positives = 137/276 (49%), Gaps = 15/276 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ ++LGKG+FG+VIL K+K TG+ A+K++ K + K + L E ++L+ H Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L F+ V E GGELF + + FSE A +++S + Y+H Sbjct: 127 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 186 Query: 268 KNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 K +V+RDLK ENL+L KD +I+I DFGL + MK GT Y+APEVL Sbjct: 187 K-IVHRDLKPENLLLESKSKDANIRIIDFGLS-THFEASKKMKDKIGTAYYIAPEVLHGT 244 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 Y D W GV++Y ++ G PF + + + + + F + + AK L+ Sbjct: 245 -YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLI 303 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHV 416 +L P R+ A++ + H + + + Sbjct: 304 RKMLTYVPSMRIS-----ARDALDHEWIQTYTKEQI 334 >4CFH-A nrPDB Length = 493 Score = 297 bits (760), Expect = 9e-81, Method: Composition-based stats. Identities = 105/307 (34%), Positives = 150/307 (48%), Gaps = 26/307 (8%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 RV + + LG GTFGKV + K + TG A+KIL ++ I + D V E + L+ Sbjct: 29 RVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK 88 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 RHP + L T + VMEY +GGELF ++ + E +R +I+S +DY Sbjct: 89 LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 148 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y APEV+ Sbjct: 149 CHRHM-VVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 324 NDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 Y G VD W GV++Y ++CG LPF + LF+ I P+ L P SLL Sbjct: 207 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 266 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY----F 438 +L+ DP +R K+I +H +F P+ D Y Sbjct: 267 MLQVDPMKR-----ATIKDIREHEWFKQ--------------DLPKYLFPEDPSYSSTMI 307 Query: 439 DEEFTAQ 445 D+E + Sbjct: 308 DDEALKE 314 >2JC6-A nrPDB Length = 334 Score = 296 bits (759), Expect = 1e-80, Method: Composition-based stats. Identities = 97/268 (36%), Positives = 152/268 (56%), Gaps = 16/268 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 FE+ + LG G F +V+L +EKATG+ +A+K + K+ + K+ + E VL+ +H Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE--SSIENEIAVLRKIKHEN 81 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + AL+ +++ + L VM+ +GGELF + + ++E A +++ A+ YLH Sbjct: 82 IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLH-RMG 140 Query: 270 VVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +V+RDLK ENL+ D++ I I+DFGL K G M T CGTP Y+APEVL Y Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSK-MEGKGDVMSTACGTPGYVAPEVLAQKPY 199 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSG 382 +AVD W +GV+ Y ++CG PFY+++ KLFE IL E F + AK + Sbjct: 200 SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 259 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 L++KDP +R ++ +H + AG Sbjct: 260 LMEKDPNKRYTC-----EQAARHPWIAG 282 >4CZT-A nrPDB Length = 464 Score = 296 bits (759), Expect = 1e-80, Method: Composition-based stats. Identities = 86/269 (31%), Positives = 146/269 (54%), Gaps = 9/269 (3%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R + ++E + LG+GTF KV + G A+K++ KE ++ +A E ++ Sbjct: 7 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 66 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 +HP + + + ++ FV+E+ GGELF +S ED AR Y ++++A+DY Sbjct: 67 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 126 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPEVL 321 HS + V +RDLK ENL+LD +G +K++DFGL + +++ + T CGTP Y+APEV+ Sbjct: 127 CHS-RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 322 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 + Y G D W GV+++ +M G LPF + + L++ I E P AK L+ Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLI 245 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 +L +P R+ E++++ +F Sbjct: 246 KRILDPNPATRI-----TFAEVIENEWFK 269 >4FG9-A nrPDB Length = 320 Score = 296 bits (759), Expect = 1e-80, Method: Composition-based stats. Identities = 96/271 (35%), Positives = 152/271 (56%), Gaps = 16/271 (5%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + +++ +LG G F +VIL ++K T + A+K + KE + K+ E VL + Sbjct: 17 RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME--NEIAVLHKIK 74 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + AL +++ L +M+ +GGELF + + ++E A +++ A+ YLH Sbjct: 75 HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH- 133 Query: 267 EKNVVYRDLKLENLM---LDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 + +V+RDLK ENL+ LD+D I I+DFGL K G+ + T CGTP Y+APEVL Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVLAQ 192 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSL 379 Y +AVD W +GV+ Y ++CG PFY+++ KLFE IL E F + AK Sbjct: 193 KPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDF 252 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 + L++KDP++R ++ +QH + AG Sbjct: 253 IRHLMEKDPEKRFTC-----EQALQHPWIAG 278 >5U6Y-A nrPDB Length = 461 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 85/267 (31%), Positives = 136/267 (50%), Gaps = 14/267 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 ++ + LGKG F V + G+ YA KI+ + + A+D E R+ + +HP Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 60 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L S + + GGELF + +SE A +I+ A+ + H + Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH-QMG 119 Query: 270 VVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 VV+RDLK ENL+L K +K+ DFGL E + F GTP YL+PEVL + Y Sbjct: 120 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY 179 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSG 382 G+ VD W GV++Y ++ G PF+++D +L++ I FP T+ PEAK L++ Sbjct: 180 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 239 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFA 409 +L +P +R+ A E ++H + + Sbjct: 240 MLTINPSKRI-----TAAEALKHPWIS 261 >2V7O-A nrPDB Length = 336 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 83/268 (30%), Positives = 140/268 (52%), Gaps = 14/268 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++++ + LGKG F V +K + YA KI+ + + A+D E R+ + +H Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDH-QKLEREARICRLLKH 89 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L S V + GGELF + +SE A +I+ +++++H + Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIH-Q 148 Query: 268 KNVVYRDLKLENLMLDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 ++V+RDLK ENL+L +K+ DFGL E + F GTP YL+PEVL + Sbjct: 149 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 208 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 YG+ VD W GV++Y ++ G PF+++D KL++ I FP T+ PEAK+L+ Sbjct: 209 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 268 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + +L +P +R+ A + ++H + Sbjct: 269 NQMLTINPAKRI-----TADQALKHPWV 291 >2VZ6-A nrPDB Length = 313 Score = 295 bits (756), Expect = 3e-80, Method: Composition-based stats. Identities = 85/267 (31%), Positives = 136/267 (50%), Gaps = 14/267 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 ++ + LGKG F V + G+ YA KI+ + + A+D E R+ + +HP Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 82 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L S + + GGELF + +SE A +I+ A+ + H + Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH-QMG 141 Query: 270 VVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 VV+RDLK ENL+L K +K+ DFGL E + F GTP YL+PEVL + Y Sbjct: 142 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY 201 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSG 382 G+ VD W GV++Y ++ G PF+++D +L++ I FP T+ PEAK L++ Sbjct: 202 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 261 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFA 409 +L +P +R+ A E ++H + + Sbjct: 262 MLTINPSKRI-----TAAEALKHPWIS 283 >3H4J-B nrPDB Length = 336 Score = 295 bits (755), Expect = 3e-80, Method: Composition-based stats. Identities = 100/326 (30%), Positives = 163/326 (50%), Gaps = 20/326 (6%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + + + LG+G+FGKV L T + A+K + ++++ D E L+ R Sbjct: 8 IGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLR 67 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L T + V+EYA GGELF ++ ++ +ED R + +I+ A++Y H Sbjct: 68 HPHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHR 126 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 K +V+RDLK ENL+LD + ++KI DFGL + DG +KT CG+P Y APEV+ Y Sbjct: 127 HK-IVHRDLKPENLLLDDNLNVKIADFGLS-NIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 327 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 G VD W G+V+Y M+ GRLPF ++ LF+ + P L P A+SL+ ++ Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRMIV 244 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQ 445 DP QR+ +EI + +F + Y + + +V Y D ++ Sbjct: 245 ADPMQRI-----TIQEIRRDPWF-NVNLPD-YLRPME-----EVQG----SYADSRIVSK 288 Query: 446 MITITPPDQDDSMECVDSERRPHFPQ 471 + +D +E + S+ + Sbjct: 289 LGEAMGFSEDYIVEALRSDENNEVKE 314 >2YZA-A nrPDB Length = 276 Score = 295 bits (755), Expect = 3e-80, Method: Composition-based stats. Identities = 98/267 (36%), Positives = 140/267 (52%), Gaps = 8/267 (2%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 RV + + LG GTFGKV + + + TG A+KIL ++ I + D V E + L+ Sbjct: 7 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 66 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 RHP + L T VMEY +GGELF ++ + E AR +I+SA+DY Sbjct: 67 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 126 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 H VV+RDLK EN++LD + KI DFGL + DG ++ CG+P Y APEV+ Sbjct: 127 CHRHM-VVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRDSCGSPNYAAPEVISG 184 Query: 324 NDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 Y G VD W GV++Y ++CG LPF ++ LF+ I P L +LL Sbjct: 185 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 244 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFA 409 +L+ DP +R K+I +H +F Sbjct: 245 MLQVDPLKR-----ATIKDIREHEWFK 266 >3BHH-A nrPDB Length = 295 Score = 294 bits (752), Expect = 7e-80, Method: Composition-based stats. Identities = 87/268 (32%), Positives = 135/268 (50%), Gaps = 14/268 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +E++ + +GKG F V + TG YA KI+ + + A+D E R+ + +H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDH-QKLEREARICRLLKH 62 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 + L S V + GGELF + +SE A +I+ A+ + H + Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH-Q 121 Query: 268 KNVVYRDLKLENLMLDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 VV+RDLK ENL+L +K+ DFGL E D F GTP YL+PEVL Sbjct: 122 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKE 181 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 YG+ VD W GV++Y ++ G PF+++D KL++ I FP T+ PEAK+L+ Sbjct: 182 AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 241 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + +L +P +R+ A E ++H + Sbjct: 242 NQMLTINPAKRI-----TAHEALKHPWV 264 >5IG1-A nrPDB Length = 344 Score = 294 bits (752), Expect = 7e-80, Method: Composition-based stats. Identities = 88/265 (33%), Positives = 144/265 (54%), Gaps = 15/265 (5%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 ++GKG F V K TG A+K++ + + + E+ E + + +H + +++ Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRS-SEINKIKREIGICSSLQHEHIVSMR 82 Query: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 +F+ V EY +GGELF + + ++E A +I+SAL + HS KN+++RD Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHS-KNIIHRD 141 Query: 275 LKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVD 331 LK ENL+L D + +KITDFGL ++ G T F GTP YL+PEV+ Y AVD Sbjct: 142 LKPENLLLASKDPNAPVKITDFGLAV-IMEQGPTYFGFAGTPGYLSPEVIRRVPYDTAVD 200 Query: 332 WWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLKKD 387 W GV++Y ++ G PF+ +DH+KL+ I + FP ++ AK L+ +L+ + Sbjct: 201 VWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEPN 260 Query: 388 PKQRLGGGSEDAKEIMQHRFFAGIV 412 PK+R +E++QH + A Sbjct: 261 PKRR-----PTVQELLQHPWIARRD 280 >4D28-A nrPDB Length = 446 Score = 293 bits (751), Expect = 8e-80, Method: Composition-based stats. Identities = 87/264 (32%), Positives = 135/264 (51%), Gaps = 7/264 (2%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + ++E + +G+GTF KV + TG A+KI+ K I+ V E +++ R Sbjct: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L + ++ V+E+ GGELF + + ED +R Y ++V A+ + HS Sbjct: 68 HPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHS 127 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 K V +RDLK ENL+LD +G++K++DFGL + + CGTP Y+APEVL Y Sbjct: 128 -KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGY 186 Query: 327 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 G A D W GV+++ ++ G LPF D L+ I E P E K L+ +L Sbjct: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIHRILD 246 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFA 409 +PK R+ I + +F Sbjct: 247 PNPKTRIQIQG-----IKKDPWFR 265 >3MA6-A nrPDB Length = 298 Score = 293 bits (749), Expect = 2e-79, Method: Composition-based stats. Identities = 84/270 (31%), Positives = 135/270 (50%), Gaps = 15/270 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ ++LGKG+FG+VIL K+K TG+ A+K++ K + K + L E ++L+ H Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 91 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L F+ V E GGELF + + FSE A +++S + Y+H Sbjct: 92 PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 151 Query: 268 KNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 K +V+RDLK ENL+L KD +I+I DFGL + MK GT Y+APEVL Sbjct: 152 K-IVHRDLKPENLLLESKSKDANIRIIDFGLS-THFEASKKMKDKIGTAYYIAPEVLHGT 209 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 Y D W GV++Y ++ G PF + + + + + F + + AK L+ Sbjct: 210 -YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLI 268 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 +L P R+ A++ + H + Sbjct: 269 RKMLTYVPSMRIS-----ARDALDHEWIQT 293 >3ORZ-A nrPDB Length = 316 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 104/280 (37%), Positives = 167/280 (59%), Gaps = 6/280 (2%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +F++ K+LG+G+F V+L +E AT R YA+KIL+K I+ +++V + E V+ H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 PF L + FQ ++L F + YA GEL ++ + F E RFY AEIVSAL+YLH Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHG- 155 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG--ATMKTFCGTPEYLAPEVLEDND 325 K +++RDLK EN++L++D HI+ITDFG K + A +F GT +Y++PE+L + Sbjct: 156 KGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS 215 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 ++ D W LG ++Y+++ G PF + +F+ I+ E FP P+A+ L+ LL Sbjct: 216 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLV 275 Query: 386 KDPKQRLGGGS-EDAKEIMQHRFFAGIVWQHVYEKKLSPP 424 D +RLG E + H FF + W++++++ +PP Sbjct: 276 LDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 313 >2BDW-A nrPDB Length = 362 Score = 292 bits (747), Expect = 3e-79, Method: Composition-based stats. Identities = 85/268 (31%), Positives = 136/268 (50%), Gaps = 15/268 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ + LGKG F V K TG +A KI+ + + A+D E R+ + +H Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARD-FQKLEREARICRKLQH 87 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L S Q V + GGELF + +SE A +I+ ++ Y HS Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 147 Query: 268 KNVVYRDLKLENLMLDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 +V+R+LK ENL+L +K+ DFGL E + D F GTP YL+PEVL+ + Sbjct: 148 -GIVHRNLKPENLLLASKAKGAAVKLADFGLAIE-VNDSEAWHGFAGTPGYLSPEVLKKD 205 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 Y + VD W GV++Y ++ G PF+++D +L+ I +P T+ PEAKSL+ Sbjct: 206 PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLI 265 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +L +PK+R+ A + ++ + Sbjct: 266 DSMLTVNPKKRI-----TADQALKVPWI 288 >3SOA-A nrPDB Length = 444 Score = 290 bits (743), Expect = 9e-79, Method: Composition-based stats. Identities = 84/269 (31%), Positives = 136/269 (50%), Gaps = 14/269 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 E++ + LGKG F V + G+ YA I+ + + A+D E R+ + +H Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDH-QKLEREARICRLLKH 69 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L S + + GGELF + +SE A +I+ A+ + H + Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH-Q 128 Query: 268 KNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 VV+R+LK ENL+L K +K+ DFGL E + F GTP YL+PEVL + Sbjct: 129 MGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 YG+ VD W GV++Y ++ G PF+++D +L++ I FP T+ PEAK L+ Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + +L +P +R+ A E ++H + + Sbjct: 249 NKMLTINPSKRI-----TAAEALKHPWIS 272 >4JXF-A nrPDB Length = 266 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 80/265 (30%), Positives = 136/265 (51%), Gaps = 7/265 (2%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + +F+ LLGKG+F V + TG A+K++ K+ + V E ++ Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEIVSALDYL 264 +HP + L F+ + + V+E + GE+ +L + FSE+ AR + +I++ + YL Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 HS +++RDL L NL+L ++ +IKI DFGL + T CGTP Y++PE+ + Sbjct: 125 HSH-GILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRS 183 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384 +G D W LG + Y ++ GR PF + +++ + P L EAK L+ LL Sbjct: 184 AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLL 243 Query: 385 KKDPKQRLGGGSEDAKEIMQHRFFA 409 +++P RL S ++ H F + Sbjct: 244 RRNPADRLSLSS-----VLDHPFMS 263 >3KK8-A nrPDB Length = 284 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 85/268 (31%), Positives = 136/268 (50%), Gaps = 15/268 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ + LGKG F V K TG +A KI+ + + A+D E R+ + +H Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARD-FQKLEREARICRKLQH 64 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L S Q V + GGELF + +SE A +I+ ++ Y HS Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 124 Query: 268 KNVVYRDLKLENLMLDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 +V+R+LK ENL+L +K+ DFGL E + D F GTP YL+PEVL+ + Sbjct: 125 -GIVHRNLKPENLLLASKAKGAAVKLADFGLAIE-VNDSEAWHGFAGTPGYLSPEVLKKD 182 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 Y + VD W GV++Y ++ G PF+++D +L+ I +P T+ PEAKSL+ Sbjct: 183 PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLI 242 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +L +PK+R+ A + ++ + Sbjct: 243 DSMLTVNPKKRI-----TADQALKVPWI 265 >4YHJ-A nrPDB Length = 584 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 131/426 (30%), Positives = 207/426 (48%), Gaps = 39/426 (9%) Query: 56 SVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFH----VETPEEREEWTTAIQTVADGLK 111 +VA+ ++ E R + ++++R F+ PE + + GLK Sbjct: 86 AVAEYEVADDED-RSDC-------GLSILDRFFNDKLAAPLPEIPPD---VVTECRLGLK 134 Query: 112 KQEEEEM----------DFRSGSPSDNSGAEEMEVSLAKPKH----RVTMNEFEYLKLLG 157 ++ + ++ G P + + K VT N F + ++LG Sbjct: 135 EENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLG 194 Query: 158 KGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSF 217 KG FG+V + +ATG+ YA K L+K+ I + A L E R+L+ + F+ +L Y++ Sbjct: 195 KGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAY 254 Query: 218 QTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 +T D LC V+ NGG+L FH+ F E RA FY AE+ L+ L E+ +VYRDL Sbjct: 255 ETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRER-IVYRDL 313 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 K EN++LD GHI+I+D GL E I +G ++ GT Y+APEV+ + Y + DWWGL Sbjct: 314 KPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGL 372 Query: 336 GVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 G ++YEM+ G PF E++ + I + + +AKS+ LL K+P +R Sbjct: 373 GCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKR 432 Query: 392 LGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT--SETDTRYFDEEFTAQMITI 449 LG E A + QH F I ++ + L PPF P D ++ + I + Sbjct: 433 LGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYL 492 Query: 450 TPPDQD 455 D+D Sbjct: 493 DTADED 498 >4UZD-A nrPDB Length = 287 Score = 288 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 88/269 (32%), Positives = 137/269 (50%), Gaps = 8/269 (2%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 K + + +FE + LGKG FG V L +EK + A+K+L K + E Sbjct: 1 MKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVE 60 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 + + RHP + L F R+ ++EYA G ++ L + F E R Y E+ +A Sbjct: 61 IQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANA 120 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 L Y HS++ V++RD+K ENL+L G +KI DFG + T CGT +YL PE+ Sbjct: 121 LSYCHSKR-VIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRRTTLCGTLDYLPPEM 177 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 +E + VD W LGV+ YE + G+ PF +++ ++ I E FP + A+ L+ Sbjct: 178 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 237 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 S LLK +P QR +E+++H + Sbjct: 238 SRLLKHNPSQR-----PMLREVLEHPWIT 261 >6BXI-A nrPDB Length = 333 Score = 288 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 107/337 (31%), Positives = 175/337 (51%), Gaps = 45/337 (13%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 R+ + +FE LK++G+G FG+V LV++K TG YAMKIL+K ++ K++V H E +L Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV 61 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + ++ + YSFQ L +ME+ GG++ L ++ +E+ +FY AE V A+D Sbjct: 62 EADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDS 121 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT------------------ 305 +H + ++RD+K +NL+LD GH+K++DFGLC K T Sbjct: 122 IH-QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 306 -----------------MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP 348 + GTP+Y+APEV Y + DWW LGV+MYEM+ G P Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 349 FYNQDHEKLFELIL--MEEIRFPR--TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 F ++ ++ ++ ++ E + FP + +AK L+ + + R+G +EI Sbjct: 241 FCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILR-FCCEWEHRIGA--PGVEEIKS 297 Query: 405 HRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEE 441 + FF G+ W+H+ E+ ++ S DT FDE Sbjct: 298 NSFFEGVDWEHIRER--PAAISIEIKSIDDTSNFDEF 332 >4LQP-A nrPDB Length = 508 Score = 288 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 114/406 (28%), Positives = 184/406 (45%), Gaps = 86/406 (21%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +F +K++GKG FG+V LV++K TG+ YAMK L K + KD++AH E VL S Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P++ +L YSFQ L +ME+ GG+L L R ++F+ED RFY AE + A++ +H + Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIH-K 220 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEG---------------------------- 299 ++R +K +N+++D GHIK++DFGL Sbjct: 221 LGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTY 280 Query: 300 ----------------------IKDGATMKTFCGTPEYLA-----------PEVLEDNDY 326 + + ++T+ + +A PE+ Y Sbjct: 281 NANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGY 340 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE--IRFPR--TLGPEAKSLLSG 382 G+ DWW LG +MYE + G PF ++ ++ + I+ E ++FP + EA+ L+ Sbjct: 341 GQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRR 400 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442 LL QRLG A EI H FF G+ W + +++ P+ P+++S TDTR+F + Sbjct: 401 LLTH-ADQRLGRHG-GADEIKSHPFFRGVDWNTI--RQVEAPYIPKLSSITDTRFFPTDE 456 Query: 443 TAQMITITPPDQDDSMECVDSERR-----------PHFPQFSYSAS 477 + PD + + P Y S Sbjct: 457 LENV-----PDSPAMAQAAKQREQMTKQGGSAPVKEDLPFIGYEYS 497 >3C51-A nrPDB Length = 543 Score = 287 bits (735), Expect = 6e-78, Method: Composition-based stats. Identities = 106/315 (33%), Positives = 171/315 (54%), Gaps = 17/315 (5%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 ++LG+G FG+V + KATG+ YA K L K+ + + + E ++L F+ +L Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL 250 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSR----ERVFSEDRARFYGAEIVSALDYLHSEKN 269 Y+F+T LC VM NGG++ +H+ F E RA FY A+IVS L++LH ++N Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLH-QRN 309 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 ++YRDLK EN++LD DG+++I+D GL E K + GTP ++APE+L +Y + Sbjct: 310 IIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFS 369 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 VD++ LGV +YEM+ R PF + ++++L + +L + + +P P +K LL+ Sbjct: 370 VDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQ 429 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ-----VTSETDTRYFDE 440 KDP++RLG + H F I W+ + L+PPF P + D F Sbjct: 430 KDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNIQDVGAF-- 487 Query: 441 EFTAQMITITPPDQD 455 T + + D + Sbjct: 488 -STVKGVAFEKADTE 501 >3D2K-A nrPDB Length = 272 Score = 287 bits (735), Expect = 7e-78, Method: Composition-based stats. Identities = 87/268 (32%), Positives = 136/268 (50%), Gaps = 8/268 (2%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K + T+ +F+ + LGKG FG V L +E+ + A+K+L K + E + Sbjct: 6 KRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEI 65 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 + RHP + L F R+ ++EYA G ++ L + F E R Y E+ +AL Sbjct: 66 QSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANAL 125 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 Y HS++ V++RD+K ENL+L +G +KI DFG + T CGT +YL PE++ Sbjct: 126 SYCHSKR-VIHRDIKPENLLLGSNGELKIADFGWSVHA--PSSRRTTLCGTLDYLPPEMI 182 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 E + VD W LGV+ YE + G PF +++ + I E FP + A+ L+S Sbjct: 183 EGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLIS 242 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 LLK + QRL E+++H + Sbjct: 243 RLLKHNASQRL-----TLAEVLEHPWIK 265 >3NCG-A nrPDB Length = 486 Score = 285 bits (729), Expect = 3e-77, Method: Composition-based stats. Identities = 85/282 (30%), Positives = 137/282 (48%), Gaps = 16/282 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + + +LGKG+FG+V+ K++ T + YA+K++ K KD + L E +L+ H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKD-TSTILREVELLKKLDH 80 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L + V E GGELF + + + FSE A ++ S + Y+H + Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH-K 139 Query: 268 KNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 N+V+RDLK EN++L +KD IKI DFGL + MK GT Y+APEVL Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLS-TCFQQNTKMKDRIGTAYYIAPEVLRGT 198 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 Y D W GV++Y ++ G PFY ++ + + + + F RT+ +AK L+ Sbjct: 199 -YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLI 257 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLS 422 +L P R+ A + ++H + + L Sbjct: 258 RKMLTFHPSLRI-----TATQCLEHPWIQKYSSETPTISDLP 294 >3LIJ-A nrPDB Length = 494 Score = 285 bits (729), Expect = 4e-77, Method: Composition-based stats. Identities = 87/305 (28%), Positives = 143/305 (46%), Gaps = 22/305 (7%) Query: 114 EEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATG 173 E + G G K ++ +K LG G +G+V+L ++K T Sbjct: 9 SGRENLYFQGDLQATPGM------FITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTH 62 Query: 174 RYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGG 233 A+KI++K + + L E VL+ HP + L F+ VME GG Sbjct: 63 VERAIKIIRKTSVSTSSN-SKLLEEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGG 121 Query: 234 ELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML---DKDGHIKI 290 ELF + F+E A +++S + YLH + N+V+RDLK ENL+L +KD IKI Sbjct: 122 ELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH-KHNIVHRDLKPENLLLESKEKDALIKI 180 Query: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350 DFGL ++ MK GT Y+APEVL Y D W +GV+++ ++ G PF Sbjct: 181 VDFGLS-AVFENQKKMKERLGTAYYIAPEVLR-KKYDEKCDVWSIGVILFILLAGYPPFG 238 Query: 351 NQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406 Q +++ + + F + + AK L+ +L+ D ++R+ A++ ++H Sbjct: 239 GQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQMLQFDSQRRIS-----AQQALEHP 293 Query: 407 FFAGI 411 + + Sbjct: 294 WIKEM 298 >3DFA-A nrPDB Length = 286 Score = 284 bits (728), Expect = 4e-77, Method: Composition-based stats. Identities = 84/269 (31%), Positives = 135/269 (50%), Gaps = 16/269 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + + +LGKG+FG+V+ K++ T + YA+K++ K KD + L E +L+ H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKD-TSTILREVELLKKLDH 80 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L + V E GGELF + + + FSE A ++ S + Y+H + Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH-K 139 Query: 268 KNVVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 N+V+RDLK EN++L +KD IKI DFGL + MK GT Y+APEVL Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLS-TCFQQNTKMKDRIGTAYYIAPEVLRGT 198 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLL 380 Y D W GV++Y ++ G PFY ++ + + + + F RT+ +AK L+ Sbjct: 199 -YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLI 257 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 +L P R+ A + ++H + Sbjct: 258 RKMLTFHPSLRI-----TATQCLEHPWIQ 281 >4CQG-A nrPDB Length = 331 Score = 284 bits (727), Expect = 5e-77, Method: Composition-based stats. Identities = 82/261 (31%), Positives = 142/261 (54%), Gaps = 10/261 (3%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 +E + +G G F KV L TG A+KI+ K + + ++ TE L++ RH Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALKSLRHQH 68 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L + +T +++ V+EY GGELF ++ + SE+ R +I+SA+ Y+HS+ Sbjct: 69 ICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQ-G 127 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGL-CKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-G 327 +RDLK ENL+ D++ +K+ DFGL K ++ CG+ Y APE+++ Y G Sbjct: 128 YAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLG 187 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKD 387 D W +G+++Y +MCG LPF + + L++ I+ + P+ L P + LL +L+ D Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVD 247 Query: 388 PKQRLGGGSEDAKEIMQHRFF 408 PK+R+ + ++ H + Sbjct: 248 PKKRISM-----RNLLNHPWV 263 >2HAK-A nrPDB Length = 328 Score = 284 bits (727), Expect = 5e-77, Method: Composition-based stats. Identities = 105/298 (35%), Positives = 156/298 (52%), Gaps = 14/298 (4%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + + + K +GKG F KV L + TGR A+KI+ K + + E R++ Sbjct: 10 EQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTS-LQKLFREVRIM 68 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + HP + L +T L VMEYA+GGE+F +L E AR +IVSA+ Sbjct: 69 KILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 128 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 Y H +K +V+RDLK ENL+LD D +IKI DFG E G + TFCG+P Y APE+ + Sbjct: 129 YCH-QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFT-VGNKLDTFCGSPPYAAPELFQ 186 Query: 323 DNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 Y G VD W LGV++Y ++ G LPF Q+ ++L E +L + R P + + ++LL Sbjct: 187 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 246 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439 LL +P +R ++IM+ R+ E++L P +P DT+ D Sbjct: 247 KLLVLNPIKR-----GSLEQIMKDRWMN----VGHEEEELKPYTEPDP-DFNDTKRID 294 >2JAM-A nrPDB Length = 304 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 93/268 (34%), Positives = 144/268 (53%), Gaps = 18/268 (6%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F ++++LG G F +V LVK++ TG+ +A+K +KK + E VL+ +H Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE---NEIAVLKKIKHEN 67 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L+ +++ VM+ +GGELF + V++E A +++SA+ YLH E Sbjct: 68 IVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLH-ENG 126 Query: 270 VVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +V+RDLK ENL+ +++ I ITDFGL K ++ M T CGTP Y+APEVL Y Sbjct: 127 IVHRDLKPENLLYLTPEENSKIMITDFGLSK--MEQNGIMSTACGTPGYVAPEVLAQKPY 184 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSG 382 +AVD W +GV+ Y ++CG PFY + KLFE I F + AK + Sbjct: 185 SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICH 244 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 LL+KDP +R ++ + H + G Sbjct: 245 LLEKDPNERYTC-----EKALSHPWIDG 267 >4RGJ-A nrPDB Length = 520 Score = 282 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 89/326 (27%), Positives = 156/326 (47%), Gaps = 19/326 (5%) Query: 95 EREEWTTAIQTVADGLKKQEEEEMDFRSGSP--SDNSGAEEMEVSLAKPKHRVTMNE-FE 151 + E T +++ G ++ E +E ++ ++ + V NE ++ Sbjct: 4 KNEHHKTNKKSLKGGNERHEMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYK 63 Query: 152 YLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLT 211 +K+LGKG+FG+VIL ++K TG YA+K++ K+ + K + L E +L+ H + Sbjct: 64 GIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIM 123 Query: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 L F+ ++ V + GGELF + + F E A +I+S + Y+H + NVV Sbjct: 124 KLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMH-KNNVV 182 Query: 272 YRDLKLENLML----DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +RDLK EN++L +D IKI DFGL + MK GT Y+AP+VL Y Sbjct: 183 HRDLKPENILLETKNKEDMIIKIIDFGLS-THFEYSKKMKDKIGTAYYIAPDVLHGT-YD 240 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGPEAKSLLSGL 383 D W GV++Y ++ G PF + + + + + F + + +AK L+ + Sbjct: 241 EKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKM 300 Query: 384 LKKDPKQRLGGGSEDAKEIMQHRFFA 409 L R+ A++ ++H + Sbjct: 301 LMYTSAVRIS-----ARDALEHEWIK 321 >3COM-A nrPDB Length = 314 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 77/291 (26%), Positives = 128/291 (43%), Gaps = 19/291 (6%) Query: 124 SPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK 183 +P + E SL K V F+ L+ LG+G++G V K TG+ A+K + Sbjct: 9 NPPRRQLKKLDEDSLTKQPEEV----FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV 64 Query: 184 EVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RE 242 E ++ + E ++Q P + S+ + L VMEY G + + R Sbjct: 65 E-----SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN 119 Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD 302 + +ED + L+YLH + + +RD+K N++L+ +GH K+ DFG+ + Sbjct: 120 KTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDT 178 Query: 303 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 362 A T GTP ++APEV+++ Y D W LG+ EM G+ P+ + + +I Sbjct: 179 MAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIP 238 Query: 363 MEE---IRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 R P + L K P+QR A +++QH F Sbjct: 239 TNPPPTFRKPELWSDNFTDFVKQCLVKSPEQR-----ATATQLLQHPFVRS 284 >4YZB-A nrPDB Length = 491 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 89/299 (29%), Positives = 145/299 (48%), Gaps = 17/299 (5%) Query: 123 GSPSDNSGAEEMEVSLAKPKHRVTM--NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180 GSP+ + + +H + ++ ++LGKG+FG+VIL K+K TG+ YA+K+ Sbjct: 3 GSPAASKSDKLAATPGMFVQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKV 62 Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240 + K + K + L E +L+ HP + L F+ V E GGELF + Sbjct: 63 ISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEII 122 Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCK 297 + FSE A +++S + Y+H K +V+RDLK ENL+L+ KD +I+I DFGL Sbjct: 123 SRKRFSEVDAARIIRQVLSGITYMHKNK-IVHRDLKPENLLLENKRKDANIRIIDFGLS- 180 Query: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357 + MK GT Y+APEVL Y D W GV++Y ++ G PF + + Sbjct: 181 THFESTKKMKDKIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEFDI 239 Query: 358 FELILMEEIRFP----RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 + + + F + + AK L+ +L P R+ A++ ++H + Sbjct: 240 LKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRIS-----ARDALEHEWLKTTD 293 >4FR4-A nrPDB Length = 384 Score = 282 bits (721), Expect = 3e-76, Method: Composition-based stats. Identities = 99/295 (33%), Positives = 161/295 (54%), Gaps = 12/295 (4%) Query: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199 V + FE L+ +GKG+FGKV +V++ T + YAMK + K+ V ++EV + E Sbjct: 7 DENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKEL 66 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 +++Q HPFL L YSFQ + + V++ GG+L +HL + F E+ + + E+V Sbjct: 67 QIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVM 126 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 ALDYL +++ +++RD+K +N++LD+ GH+ ITDF + + + T GT Y+APE Sbjct: 127 ALDYLQNQR-IIHRDMKPDNILLDEHGHVHITDFNIA-AMLPRETQITTMAGTKPYMAPE 184 Query: 320 VLEDND---YGRAVDWWGLGVVMYEMMCGRLPFY---NQDHEKLFELILMEEIRFPRTLG 373 + Y AVDWW LGV YE++ GR P++ + +++ + +P Sbjct: 185 MFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWS 244 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428 E SLL LL+ +P QR S ++ + I W V++K+L P F P Sbjct: 245 QEMVSLLKKLLEPNPDQRFSQLS----DVQNFPYMNDINWDAVFQKRLIPGFIPN 295 >6C9D-A nrPDB Length = 459 Score = 281 bits (720), Expect = 4e-76, Method: Composition-based stats. Identities = 104/298 (34%), Positives = 155/298 (52%), Gaps = 14/298 (4%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + + + K +GKG F KV L + TGR A+KI+ K + + E R++ Sbjct: 16 EQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTS-LQKLFREVRIM 74 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + HP + L +T L VMEYA+GGE+F +L E AR +IVSA+ Sbjct: 75 KILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 134 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 Y H +K +V+RDLK ENL+LD D +IKI DFG E G + FCG+P Y APE+ + Sbjct: 135 YCH-QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFT-VGNKLDEFCGSPPYAAPELFQ 192 Query: 323 DNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 Y G VD W LGV++Y ++ G LPF Q+ ++L E +L + R P + + ++LL Sbjct: 193 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 252 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439 LL +P +R ++IM+ R+ E++L P +P DT+ D Sbjct: 253 KLLVLNPIKR-----GSLEQIMKDRWMN----VGHEEEELKPYTEPDP-DFNDTKRID 300 >4D2V-A nrPDB Length = 356 Score = 280 bits (717), Expect = 8e-76, Method: Composition-based stats. Identities = 87/272 (31%), Positives = 140/272 (51%), Gaps = 15/272 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 +E + +G G F KV L TG A+KI+ K + + ++ TE L+N RH Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQH 88 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L + +T +++ V+EY GGELF ++ + SE+ R +IVSA+ Y+HS+ Sbjct: 89 ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQ-G 147 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGL-CKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-G 327 +RDLK ENL+ D+ +K+ DFGL K ++ CG Y APE+++ Y G Sbjct: 148 YAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLG 207 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKD 387 D W +G+++Y +MCG LPF + L I+ + P+ L P + LL +L+ D Sbjct: 208 SEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVD 267 Query: 388 PKQRLGGGSEDAKEIMQHRFF-----AGIVWQ 414 PK+R+ K ++ H + + WQ Sbjct: 268 PKKRISM-----KNLLNHPWIMQDYNYPVEWQ 294 >3DB8-A nrPDB Length = 317 Score = 278 bits (712), Expect = 3e-75, Method: Composition-based stats. Identities = 82/285 (28%), Positives = 136/285 (47%), Gaps = 9/285 (3%) Query: 126 SDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 185 ++ +E+ L P+ TM + + LGKG F K + + T +A K++ K + Sbjct: 23 PKSAPLKEIPDVLVDPR---TMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSM 79 Query: 186 IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF 245 ++ + TE + ++ +P + F+ D + V+E L R + Sbjct: 80 LLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAV 139 Query: 246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT 305 +E AR++ + + + YLH+ + V++RDLKL NL L+ D +KI DFGL + DG Sbjct: 140 TEPEARYFMRQTIQGVQYLHNNR-VIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGER 198 Query: 306 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE 365 K CGTP Y+APEVL + VD W LG ++Y ++ G+ PF ++ + I E Sbjct: 199 KKDLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNE 258 Query: 366 IRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 PR + P A +L+ +L DP R E++ FF Sbjct: 259 YSVPRHINPVASALIRRMLHADPTLR-----PSVAELLTDEFFTS 298 >4JG6-A nrPDB Length = 355 Score = 277 bits (709), Expect = 8e-75, Method: Composition-based stats. Identities = 89/333 (26%), Positives = 153/333 (45%), Gaps = 28/333 (8%) Query: 137 SLAKPKHRVTM---NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA 193 S+ + HR ++ + +E + +G G++ KAT +A+KI+ K +E+ Sbjct: 21 SIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIE 80 Query: 194 HTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253 +L+ +HP + LK + + V E GGEL + R++ FSE A Sbjct: 81 ------ILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAV 134 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTF 309 I ++YLH++ VV+RDLK N++ +D+ G+ I+I DFG K+ + + T Sbjct: 135 LFTITKTVEYLHAQ-GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP 193 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEI 366 C T ++APEVLE Y A D W LGV++Y M+ G PF + E++ I + Sbjct: 194 CYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKF 253 Query: 367 RFP----RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLS 422 ++ AK L+S +L DP QRL A +++H + + W + + +L+ Sbjct: 254 SLSGGYWNSVSDTAKDLVSKMLHVDPHQRL-----TAALVLRHPWI--VHWDQLPQYQLN 306 Query: 423 PPFKPQVTSETDTRYFDEEFTAQMITITPPDQD 455 P + + Q + P + Sbjct: 307 RQDAPHLVKGAMAATYSALNRNQSPVLEPVGRS 339 >4LG4-A nrPDB Length = 299 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 74/280 (26%), Positives = 127/280 (45%), Gaps = 19/280 (6%) Query: 135 EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH 194 E SL K V F+ L+ LG+G++G V K +G+ A+K + E ++ Sbjct: 2 EDSLTKQPEEV----FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE-----SDLQE 52 Query: 195 TLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFY 253 + E ++Q P++ S+ + L VMEY G + + R + ED Sbjct: 53 IIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATI 112 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP 313 + L+YLH + + +R++K N++L+ +GH K+ DFG+ + A T GTP Sbjct: 113 LKSTLKGLEYLHFMRKI-HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTP 171 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPR 370 ++APEV+++ Y D W LG+ EM G+ P+ + + +I R P Sbjct: 172 FWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPE 231 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 + + L K+P+QR A +++QH F Sbjct: 232 LWSDDFTDFVKKCLVKNPEQR-----ATATQLLQHPFIKN 266 >4YNZ-A nrPDB Length = 342 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 94/324 (29%), Positives = 166/324 (51%), Gaps = 12/324 (3%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + + K LGKG G V L T + A+KI+ +E + ++ + E +L+ Sbjct: 9 VGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 67 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + L ++ L V+E+ +GGELF +L ++ + AR + +I+SALD+ HS Sbjct: 68 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 127 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 ++ +RDLK ENL+LD+ +I+I DFG+ + D + ++T CG+P Y PEV+ Y Sbjct: 128 H-SICHRDLKPENLLLDERNNIRIADFGMASLQVGD-SLLETSCGSPHYACPEVIRGEKY 185 Query: 327 -GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLK 385 GR D W GV+++ ++ G LPF + + +L E + P + P+ +SLL G+++ Sbjct: 186 DGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIE 245 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQ 445 D +RL + I +H ++ G ++ E + P K Q+ S D + Sbjct: 246 VDAARRL-----TLEHIQKHIWYIGG--KNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDS 298 Query: 446 MITIT-PPDQDDSMECVDSERRPH 468 M ++ D++ ++ + SE Sbjct: 299 MHSLGCFRDRNKLLQDLLSEEENQ 322 >4NIF-A nrPDB Length = 333 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 86/319 (26%), Positives = 145/319 (45%), Gaps = 25/319 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + + + +G G++ + KAT YA+K++ K +E+ +L+ +H Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE------ILLRYGQH 61 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + LK + + V E GGEL + R++ FSE A F I ++YLHS+ Sbjct: 62 PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ 121 Query: 268 KNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 VV+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++APEVL+ Sbjct: 122 -GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR 180 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFP----RTLGPEA 376 Y D W LG+++Y M+ G PF + E++ I + T+ A Sbjct: 181 QGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETA 240 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 436 K L+S +L DP QRL AK+++QH + + + +LS V Sbjct: 241 KDLVSKMLHVDPHQRL-----TAKQVLQHPWVTQKD--KLPQSQLSHQDLQLVKGAMAAT 293 Query: 437 YFDEEFTAQMITITPPDQD 455 Y + + P + Sbjct: 294 YSALNSSKPTPQLKPIESS 312 >4I6B-A nrPDB Length = 308 Score = 275 bits (704), Expect = 3e-74, Method: Composition-based stats. Identities = 78/267 (29%), Positives = 127/267 (47%), Gaps = 6/267 (2%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 T + K LGKG F K + + + YA KI+ + + E + Sbjct: 23 DPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELH 82 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + H + + F+ + + ++EY + + L +V +E R+Y +IVS L Sbjct: 83 RILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLK 142 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 YLH ++ +++RDLKL N +++ +K+ DFGL +T CGTP YL+PEVL Sbjct: 143 YLHEQE-ILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN 201 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 +G D W LG VMY M+ GR PF + ++ + I P +L AK L++ Sbjct: 202 KQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIAS 261 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFA 409 +L K+P+ R +I++H FF Sbjct: 262 MLSKNPEDR-----PSLDDIIRHDFFT 283 >5WAX-A nrPDB Length = 310 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 90/270 (33%), Positives = 135/270 (50%), Gaps = 20/270 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + +E ++ +G G FG L++ +A G+ A+K +++ + ++ E ++ RH Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDEN----VQREIINHRSLRH 66 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + K T L VMEYA+GGELF + FSED ARF+ +++S + Y HS Sbjct: 67 PNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHS- 125 Query: 268 KNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 V +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL + Sbjct: 126 MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLLKKE 184 Query: 326 YGRAV-DWWGLGVVMYEMMCGRLPFYNQDHE----KLFELILMEEIRFPR--TLGPEAKS 378 Y V D W GV +Y M+ G PF + D K + IL + P + PE + Sbjct: 185 YDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQD 244 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L+S + +P R+ EI H +F Sbjct: 245 LISRIFVANPATRI-----TIPEIRNHPWF 269 >3Q5I-A nrPDB Length = 504 Score = 274 bits (700), Expect = 8e-74, Method: Composition-based stats. Identities = 81/289 (28%), Positives = 131/289 (45%), Gaps = 25/289 (8%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA--------- 188 + K + ++ LG G +G+V+L KEK A+K++KK Sbjct: 26 YVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKN 85 Query: 189 -KDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSE 247 + E +L++ HP + L F+ V E+ GGELF + F E Sbjct: 86 IEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDE 145 Query: 248 DRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG---HIKITDFGLCKEGIKDGA 304 A +I+S + YLH + N+V+RD+K EN++L+ +IKI DFGL Sbjct: 146 CDAANIMKQILSGICYLH-KHNIVHRDIKPENILLENKNSLLNIKIVDFGLS-SFFSKDY 203 Query: 305 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME 364 ++ GT Y+APEVL+ Y D W GV+MY ++CG PF Q+ + + + + Sbjct: 204 KLRDRLGTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKG 262 Query: 365 EIRFP----RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + F + + EAK L+ +L D +R A+E + R+ Sbjct: 263 KYYFDFNDWKNISDEAKELIKLMLTYDYNKRC-----TAEEALNSRWIK 306 >6AO5-A nrPDB Length = 362 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 74/280 (26%), Positives = 127/280 (45%), Gaps = 19/280 (6%) Query: 135 EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH 194 E SL K V F+ L+ LG+G++G V K +G+ A+K + E ++ Sbjct: 1 EDSLTKQPEEV----FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE-----SDLQE 51 Query: 195 TLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFY 253 + E ++Q P++ S+ + L VMEY G + + R + ED Sbjct: 52 IIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATI 111 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP 313 + L+YLH + + +R++K N++L+ +GH K+ DFG+ + A T GTP Sbjct: 112 LKSTLKGLEYLHFMRKI-HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTP 170 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPR 370 ++APEV+++ Y D W LG+ EM G+ P+ + + +I R P Sbjct: 171 FWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPE 230 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 + + L K+P+QR A +++QH F Sbjct: 231 LWSDDFTDFVKKCLVKNPEQR-----ATATQLLQHPFIKN 265 >4B8L-A nrPDB Length = 286 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 88/269 (32%), Positives = 137/269 (50%), Gaps = 8/269 (2%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 PK + T+++F+ + LGKG FG V L +EK A+K+L K + + E Sbjct: 8 PKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIE 67 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 + + RHP + + F R+ ++E+A GEL+ L + F E R+ + E+ A Sbjct: 68 IQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADA 127 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 L Y H K V++RD+K ENL++ G +KI DFG +T CGT +YL PE+ Sbjct: 128 LHYCHERK-VIHRDIKPENLLMGYKGELKIADFGWSVHA--PSLRRRTMCGTLDYLPPEM 184 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 +E + VD W GV+ YE + G PF + H + I+ +++FP L +K L+ Sbjct: 185 IEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLI 244 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 S LL+ P QRL K +M+H + Sbjct: 245 SKLLRYHPPQRLP-----LKGVMEHPWVK 268 >5XZW-A nrPDB Length = 471 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 87/319 (27%), Positives = 150/319 (47%), Gaps = 29/319 (9%) Query: 110 LKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYL-KLLGKGTFGKVILVK 168 K + + ++ S + G S +F + +++G+G F V Sbjct: 157 QNKVDRIRSNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAI 216 Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVME 228 E+ TG+ +A+KI+ K ++ + E VLQ HP + LK ++ + VME Sbjct: 217 ERTTGKTFAVKIISKRKVIGNMDG--VTRELEVLQKLNHPRIVRLKGFYEDTESYYMVME 274 Query: 229 YANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH- 287 + +GG+L ++ ED R +I++A+ Y+HS + +RDLK +N+++++D Sbjct: 275 FVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS-MGISHRDLKPDNILIEQDDPV 333 Query: 288 -IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED-------------NDYGRAVDWW 333 +KITDFGL K +G+ MKTFCGT Y+APEV+ N+Y VD W Sbjct: 334 LVKITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMW 392 Query: 334 GLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGLLKKDPK 389 +G ++Y ++ G LPF ++L++ I + EA+ + LL+ DP Sbjct: 393 SMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPN 452 Query: 390 QRLGGGSEDAKEIMQHRFF 408 R A + + H + Sbjct: 453 NR-----STAAKALNHPWI 466 >2W4O-A nrPDB Length = 349 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 102/303 (33%), Positives = 150/303 (49%), Gaps = 20/303 (6%) Query: 116 EEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY 175 + M + S + + + + + + FE LG+G V K+K T + Sbjct: 21 QSMSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKP 80 Query: 176 YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL 235 YA+K+LKK V + TE VL HP + LK F+T + V+E GGEL Sbjct: 81 YALKVLKKTV-----DKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGEL 135 Query: 236 FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK---DGHIKITD 292 F + + +SE A +I+ A+ YLH E +V+RDLK ENL+ D +KI D Sbjct: 136 FDRIVEKGYYSERDAADAVKQILEAVAYLH-ENGIVHRDLKPENLLYATPAPDAPLKIAD 194 Query: 293 FGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ 352 FGL K ++ MKT CGTP Y APE+L YG VD W +G++ Y ++CG PFY++ Sbjct: 195 FGLSK-IVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDE 253 Query: 353 DHEK-LFELILMEEIRF--P--RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407 ++ +F IL E F P + AK L+ L+ DPK+RL + +QH + Sbjct: 254 RGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTF-----QALQHPW 308 Query: 408 FAG 410 G Sbjct: 309 VTG 311 >4CSV-A nrPDB Length = 275 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 62/261 (23%), Positives = 113/261 (43%), Gaps = 12/261 (4%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K + +E + LG G FG+V K + A+K LK+ + V L E ++ Sbjct: 5 KWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS----VEEFLQEAQI 60 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSE--DRARFYGAEIVS 259 ++ +HP L L + + EY + G L +L + A++ S Sbjct: 61 MKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVAS 120 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAP 318 + YL S+ N ++RDL N ++ ++ +K+ DFGL + +D T + P ++ AP Sbjct: 121 GMAYLESQ-NFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAP 179 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRT--LGPE 375 E + N + D W G++++E+ G++P+ ++ E + R PR E Sbjct: 180 EAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERG-YRMPRPQGCPEE 238 Query: 376 AKSLLSGLLKKDPKQRLGGGS 396 L+ K P++R Sbjct: 239 IYELMLQCWNKSPEERPTFAE 259 >6FD3-A nrPDB Length = 300 Score = 272 bits (695), Expect = 3e-73, Method: Composition-based stats. Identities = 85/277 (30%), Positives = 139/277 (50%), Gaps = 18/277 (6%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 VS+ PK + + + +G+G G V + ATG+ A+K + + K+ Sbjct: 15 VSVGDPKKK-----YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LI 66 Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 + E V++ +++P + S+ D L VMEY GG L + E E + Sbjct: 67 INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCR 125 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEY 315 E + ALD+LHS + V++RD+K +N++L DG +K+TDFG C + + + T GTP + Sbjct: 126 ECLQALDFLHSNQ-VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYW 184 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL---MEEIRFPRTL 372 +APEV+ YG VD W LG++ EM+ G P+ N++ + LI E++ P L Sbjct: 185 MAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERL 244 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + L+ L+ D +R AKE++QH F Sbjct: 245 SAVFRDFLNRCLEMDVDRR-----GSAKELLQHPFLK 276 >2OU7-A nrPDB Length = 335 Score = 272 bits (695), Expect = 3e-73, Method: Composition-based stats. Identities = 80/255 (31%), Positives = 124/255 (48%), Gaps = 6/255 (2%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LGKG F K + + T +A KI+ K +++ + E + ++ H + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 F+ +D + V+E L R + +E AR+Y +IV YLH + V++RDL Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNR-VIHRDL 167 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 KL NL L++D +KI DFGL + DG K CGTP Y+APEVL + VD W + Sbjct: 168 KLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI 227 Query: 336 GVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGG 395 G +MY ++ G+ PF ++ + I E P+ + P A SL+ +L+ DP R Sbjct: 228 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR---- 283 Query: 396 SEDAKEIMQHRFFAG 410 E++ FF Sbjct: 284 -PTINELLNDEFFTS 297 >4B6L-A nrPDB Length = 281 Score = 272 bits (695), Expect = 3e-73, Method: Composition-based stats. Identities = 78/273 (28%), Positives = 129/273 (47%), Gaps = 9/273 (3%) Query: 137 SLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 196 + P+ T + +LLGKG F + + TG YA+K++ + + + L Sbjct: 1 LITDPRSGRT---YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKIL 57 Query: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 E + ++ +H + + F+ D + +E + L E R+Y + Sbjct: 58 NEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQ 117 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 316 I+S L YLH ++ +++RDLKL N + ++ +K+ DFGL KT CGTP Y+ Sbjct: 118 ILSGLKYLH-QRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYV 176 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA 376 APEVL +G D W LG VMY ++CG PF D ++ + I P +L A Sbjct: 177 APEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPA 236 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + LL+ +L+ P+ R +I++H FF Sbjct: 237 RQLLAAILRASPRDR-----PSIDQILRHDFFT 264 >4J52-A nrPDB Length = 293 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 80/255 (31%), Positives = 124/255 (48%), Gaps = 6/255 (2%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LGKG F K + + T +A KI+ K +++ + E + ++ H + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 F+ +D + V+E L R + +E AR+Y +IV YLH + V++RDL Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNR-VIHRDL 140 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 KL NL L++D +KI DFGL + DG K CGTP Y+APEVL + VD W + Sbjct: 141 KLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSI 200 Query: 336 GVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGG 395 G +MY ++ G+ PF ++ + I E P+ + P A SL+ +L+ DP R Sbjct: 201 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTAR---- 256 Query: 396 SEDAKEIMQHRFFAG 410 E++ FF Sbjct: 257 -PTINELLNDEFFTS 270 >2YCR-A nrPDB Length = 323 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 98/310 (31%), Positives = 148/310 (47%), Gaps = 28/310 (9%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIV-----AKDEVAHTLTENRV 201 +E+ K LG G G+V L E+ T + A+KI+ K D + TE + Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 L+ HP + +K F D V+E GGELF + + E + Y +++ A+ Sbjct: 69 LKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV 127 Query: 262 DYLHSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 YLH E +++RDLK EN++L +D IKITDFG K + + + M+T CGTP YLAP Sbjct: 128 QYLH-ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTYLAP 185 Query: 319 EVL---EDNDYGRAVDWWGLGVVMYEMMCGRLPF-YNQDHEKLFELILMEEIRF-PR--- 370 EVL Y RAVD W LGV+++ + G PF ++ L + I + F P Sbjct: 186 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW----QHVYEKKLSPPFK 426 + +A L+ LL DPK R +E ++H + Q + ++ K Sbjct: 246 EVSEKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDEDMKRKFQDLLSEENESTAK 300 Query: 427 PQVTSETDTR 436 PQV ++ T Sbjct: 301 PQVLAQPSTS 310 >3F3Z-A nrPDB Length = 277 Score = 271 bits (692), Expect = 6e-73, Method: Composition-based stats. Identities = 86/267 (32%), Positives = 136/267 (50%), Gaps = 18/267 (6%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 + +G+G++G+V + +K T A K + K + ++V E ++++ HP Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV---EDVDRFKQEIEIMKSLDHPN 67 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + L +F+ + + VME GGELF + +RVF E A +++SA+ Y H + N Sbjct: 68 IIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCH-KLN 126 Query: 270 VVYRDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 V +RDLK EN + D +K+ DFGL K G M+T GTP Y++P+VLE Y Sbjct: 127 VAHRDLKPENFLFLTDSPDSPLKLIDFGLA-ARFKPGKMMRTKVGTPYYVSPQVLEG-LY 184 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSG 382 G D W GV+MY ++CG PF ++ I FP + P+A+SL+ Sbjct: 185 GPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFA 409 LL K PKQR+ + ++H +F Sbjct: 245 LLTKSPKQRITSL-----QALEHEWFE 266 >5JZN-A nrPDB Length = 280 Score = 271 bits (692), Expect = 7e-73, Method: Composition-based stats. Identities = 88/273 (32%), Positives = 136/273 (49%), Gaps = 21/273 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++ + +G G F V E++T R YA+KI+KK K+ + E +L+ +H Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM--IQNEVSILRRVKH 76 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + L L VME GG+LF ++ ++E A + SA+ YLHS Sbjct: 77 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHS- 135 Query: 268 KNVVYRDLKLENLML----DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 N+V+RD+K ENL++ D +K+ DFGL + T CGTP Y+APE++ + Sbjct: 136 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP---LYTVCGTPTYVAPEIIAE 192 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEEIRFP----RTLGPEAK 377 YG VD W GV+ Y ++CG PF D E LF+ ILM ++ FP + AK Sbjct: 193 TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAK 252 Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 L++ +L D QR A ++++H + Sbjct: 253 ELITMMLLVDVDQRFS-----AVQVLEHPWVND 280 >2J90-A nrPDB Length = 304 Score = 270 bits (691), Expect = 8e-73, Method: Composition-based stats. Identities = 81/289 (28%), Positives = 136/289 (47%), Gaps = 18/289 (6%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE---VAHTLTEN 199 + + +E + LG G F V ++K TG+ YA K +KK + + E Sbjct: 21 QSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 80 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 +L+ RHP + L F+ + ++E +GGELF L+ + +ED A + +I+ Sbjct: 81 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILD 140 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDK----DGHIKITDFGLCKEGIKDGATMKTFCGTPEY 315 + YLHS++ + + DLK EN+ML + IK+ DFG+ I+ G K GTPE+ Sbjct: 141 GVHYLHSKR-IAHFDLKPENIMLLDKNVPNPRIKLIDFGIA-HKIEAGNEFKNIFGTPEF 198 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----T 371 +APE++ G D W +GV+ Y ++ G PF + ++ I F Sbjct: 199 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSN 258 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420 AK + LL KDPK+R+ + ++H + I ++V + Sbjct: 259 TSELAKDFIRRLLVKDPKRRM-----TIAQSLEHSWIKAIRRRNVRGED 302 >4C0T-A nrPDB Length = 974 Score = 270 bits (691), Expect = 1e-72, Method: Composition-based stats. Identities = 101/361 (27%), Positives = 173/361 (47%), Gaps = 27/361 (7%) Query: 65 TERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGS 124 ++ PN + R ++ T E EE + ++ EE + G+ Sbjct: 194 VDQTPPNESVERFDDSNNTVDNT-------EEEENNDDTDEIPKSETLKQNEENWEKKGA 246 Query: 125 PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE 184 M+ + + VT +F++ K LG+G++ VIL +K TG+ YA+K+L K Sbjct: 247 AVKTIKT--MDGEMKTIRRNVT--DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKR 302 Query: 185 VIVAKDEVAHTLTENRVLQNSRHP-FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER 243 I+ + +V + E L + + +L ++FQ D L FV++YA+ GEL + R Sbjct: 303 HIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYN 362 Query: 244 VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK------ 297 +E+ R +GA+I+ A+ Y+H + V++RDLK EN++LD I+ITDFG + Sbjct: 363 TLNEECTRHFGAQILDAIKYMH-DNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKN 421 Query: 298 ---EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354 E K+F GT EY++PE+LE+ G+ D W G ++Y+M+ G+ PF + Sbjct: 422 DESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNE 481 Query: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQ 414 F+ I + F + L+ +L P +R EI +H FF + ++ Sbjct: 482 YLTFQKITKLQFAFSAGFPTIIRDLIKKILVLQPSRR-----ATIPEIQKHYFFQSVDFK 536 Query: 415 H 415 Sbjct: 537 D 537 >3UC3-A nrPDB Length = 361 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 87/273 (31%), Positives = 135/273 (49%), Gaps = 20/273 (7%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + ++++K +G G FG L+++K T A+K +++ + ++ E ++ Sbjct: 17 HDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDEN----VQREIINHRS 72 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 RHP + K T L +MEYA+GGEL+ + FSED ARF+ +++S + Y Sbjct: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 Query: 265 HSEKNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 HS + +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL Sbjct: 133 HS-MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQP-KSTVGTPAYIAPEVLL 190 Query: 323 DNDYGRA-VDWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFPRT--LGPE 375 +Y D W GV +Y M+ G PF + +D+ K + IL + P + PE Sbjct: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPE 250 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L+S + DP R+ EI H +F Sbjct: 251 CCHLISRIFVADPATRIS-----IPEIKTHSWF 278 >2YAB-A nrPDB Length = 361 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 86/320 (26%), Positives = 149/320 (46%), Gaps = 27/320 (8%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE---VAHTLTE 198 K + + ++ + LG G F V +EK+TG YA K +KK A E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIERE 65 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 +L+ HP + L ++ + ++E +GGELF L+++ SE+ A + +I+ Sbjct: 66 VSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 259 SALDYLHSEKNVVYRDLKLENL-MLDKD---GHIKITDFGLCKEGIKDGATMKTFCGTPE 314 ++YLH++K + + DLK EN+ +LDK+ HIK+ DFGL E I+DG K GTPE Sbjct: 126 DGVNYLHTKK-IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPE 183 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL-- 372 ++APE++ G D W +GV+ Y ++ G PF ++ I F Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFS 243 Query: 373 --GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 430 AK + LL K+ ++RL +E ++H + + Q ++ Sbjct: 244 QTSELAKDFIRKLLVKETRKRL-----TIQEALRHPWITPVDTQQAMVRR---------E 289 Query: 431 SETDTRYFDEEFTAQMITIT 450 S + F +++ + ++ Sbjct: 290 SVVNLENFKKQYVRRRWKLS 309 >4QMW-A nrPDB Length = 310 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 86/296 (29%), Positives = 130/296 (43%), Gaps = 16/296 (5%) Query: 114 EEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATG 173 +F + SP SG M+ A P+ F L+ +GKG+FG+V + T Sbjct: 1 GPLGSEFMAHSPVQ-SGLPGMQNLKADPEEL-----FTKLEKIGKGSFGEVFKGIDNRTQ 54 Query: 174 RYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGG 233 + A+KI+ E + E E VL P++T S+ +L +MEY GG Sbjct: 55 KVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGG 112 Query: 234 ELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF 293 L E + EI+ LDYLHSEK + +RD+K N++L + G +K+ DF Sbjct: 113 SALDLL-EPGPLDETQIATILREILKGLDYLHSEKKI-HRDIKAANVLLSEHGEVKLADF 170 Query: 294 GLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353 G+ + TF GTP ++APEV++ + Y D W LG+ E+ G P Sbjct: 171 GVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELH 230 Query: 354 HEKLFELI-LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 K+ LI K + L K+P R AKE+++H+F Sbjct: 231 PMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFR-----PTAKELLKHKFI 281 >3ZUT-A nrPDB Length = 362 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 95/307 (30%), Positives = 142/307 (46%), Gaps = 32/307 (10%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + +E +K +G G FG L+++K + A+K +++ + ++ E ++ Sbjct: 16 HDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDEN----VKREIINHRS 71 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 RHP + K T L VMEYA+GGELF + FSED ARF+ +++S + Y Sbjct: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 Query: 265 HSEKNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 H+ V +RDLKLEN +LD +KI FG K + K+ GTP Y+APEVL Sbjct: 132 HA-MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQP-KSTVGTPAYIAPEVLL 189 Query: 323 DNDYGRAV-DWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFPR--TLGPE 375 +Y V D W GV +Y M+ G PF + ++ K IL + P + PE Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDT 435 + L+S + DP +R+ EI H +F K L + T T Sbjct: 250 CRHLISRIFVADPAKRIS-----IPEIRNHEWF---------LKNLPA---DLMNDNTMT 292 Query: 436 RYFDEEF 442 FDE Sbjct: 293 TQFDESD 299 >6CMJ-A nrPDB Length = 321 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 86/301 (28%), Positives = 147/301 (48%), Gaps = 22/301 (7%) Query: 124 SPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK 183 ++N + VS+ + V ++++ +GKG++G V L + YYAMK+L K Sbjct: 10 GSAENLYFQGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSK 69 Query: 184 E--------VIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQT--HDRLCFVMEYANGG 233 + I + + E +L+ HP + L D L V E N G Sbjct: 70 KKLIRQAGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG 129 Query: 234 ELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF 293 + + + SED+ARFY +++ ++YLH +K +++RD+K NL++ +DGHIKI DF Sbjct: 130 PVME-VPTLKPLSEDQARFYFQDLIKGIEYLHYQK-IIHRDIKPSNLLVGEDGHIKIADF 187 Query: 294 GLCKEGIKDGATMKTFCGTPEYLAPEVLEDND---YGRAVDWWGLGVVMYEMMCGRLPFY 350 G+ E A + GTP ++APE L + G+A+D W +GV +Y + G+ PF Sbjct: 188 GVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 247 Query: 351 NQDHEKLFELILMEEIRFPR--TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 ++ L I + + FP + + K L++ +L K+P+ R+ EI H + Sbjct: 248 DERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPWV 302 Query: 409 A 409 Sbjct: 303 T 303 >5J5T-A nrPDB Length = 370 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 80/315 (25%), Positives = 142/315 (45%), Gaps = 22/315 (6%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +FE ++ +G GT+G V + TG A+K++K E ++ A E ++++ +H Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPG---EDFAVVQQEIIMMKDCKH 60 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + A S+ D+L ME+ GG L SE + + E + L YLHS Sbjct: 61 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHS- 119 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL---EDN 324 K ++RD+K N++L +GH+K+ DFG+ + A K F GTP ++APEV Sbjct: 120 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKG 179 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR-----TLGPEAKSL 379 Y + D W +G+ E+ + P ++ + L+ + P+ Sbjct: 180 GYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHF 239 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439 + L K+PK+R A++++QH F QH+ + L+ +V + + Y D Sbjct: 240 VKMALTKNPKKR-----PTAEKLLQHPFVT----QHL-TRSLAIELLDKVNNPDHSTYHD 289 Query: 440 EEFTAQMITITPPDQ 454 + + P + Sbjct: 290 FDDDDPEPLVAVPHR 304 >4AF3-A nrPDB Length = 292 Score = 267 bits (684), Expect = 6e-72, Method: Composition-based stats. Identities = 95/299 (31%), Positives = 146/299 (48%), Gaps = 17/299 (5%) Query: 129 SGAEEMEVSLAKP---KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 185 S + ME S P T+++FE + LGKG FG V L +EK + A+K+L K Sbjct: 1 SMQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ 60 Query: 186 IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF 245 I + E + + HP + L F R+ ++EYA GEL+ L + F Sbjct: 61 IEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTF 120 Query: 246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT 305 E R E+ AL Y H +K V++RD+K ENL+L G +KI DFG Sbjct: 121 DEQRTATIMEELADALMYCHGKK-VIHRDIKPENLLLGLKGELKIADFGWSVHA--PSLR 177 Query: 306 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE 365 KT CGT +YL PE++E + VD W +GV+ YE++ G PF + H + + I+ + Sbjct: 178 RKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVD 237 Query: 366 IRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPP 424 ++FP ++ A+ L+S LL+ +P +RL A H + +++ PP Sbjct: 238 LKFPASVPTGAQDLISKLLRHNPSERLPLAQVSA-----HPWVRA------NSRRVLPP 285 >3UDB-A nrPDB Length = 317 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 96/307 (31%), Positives = 142/307 (46%), Gaps = 32/307 (10%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + +E +K +G G FG L+++K A+K +++ + ++ E ++ Sbjct: 16 HDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDEN----VKREIINHRS 71 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 RHP + K T L VMEYA+GGELF + FSED ARF+ +++S + Y Sbjct: 72 LRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYA 131 Query: 265 HSEKNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 H+ V +RDLKLEN +LD +KI DFG K + K+ GTP Y+APEVL Sbjct: 132 HA-MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQP-KSAVGTPAYIAPEVLL 189 Query: 323 DNDYGRAV-DWWGLGVVMYEMMCGRLPFYN----QDHEKLFELILMEEIRFPR--TLGPE 375 +Y V D W GV +Y M+ G PF + ++ K IL + P + PE Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDT 435 + L+S + DP +R+ EI H +F K L + T T Sbjct: 250 CRHLISRIFVADPAKRIS-----IPEIRNHEWF---------LKNLPA---DLMNDNTMT 292 Query: 436 RYFDEEF 442 FDE Sbjct: 293 TQFDESD 299 >3TAC-A nrPDB Length = 361 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 74/278 (26%), Positives = 133/278 (47%), Gaps = 20/278 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV--AHTLTENRVLQNS 205 + +E +++GKG F V + TG+ +A+KI+ + + E + Sbjct: 26 DVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHML 85 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER----VFSEDRARFYGAEIVSAL 261 +HP + L ++ + L V E+ +G +L F + + V+SE A Y +I+ AL Sbjct: 86 KHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEAL 145 Query: 262 DYLHSEKNVVYRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 Y H + N+++RD+K ++L +K+ FG+ + + G GTP ++AP Sbjct: 146 RYCH-DNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAP 204 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGP 374 EV++ YG+ VD WG GV+++ ++ G LPFY E+LFE I+ + + + Sbjct: 205 EVVKREPYGKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQWSHISE 263 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 AK L+ +L DP +R+ E + H + Sbjct: 264 SAKDLVRRMLMLDPAERI-----TVYEALNHPWLKERD 296 >2A27-A nrPDB Length = 321 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 82/282 (29%), Positives = 136/282 (48%), Gaps = 18/282 (6%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE---VAHTLTE 198 K + + ++ + LG G F V +EK+TG YA K +KK A E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 +L+ H + L ++ + ++E +GGELF L+++ SE+ A + +I+ Sbjct: 66 VSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 259 SALDYLHSEKNVVYRDLKLENL-MLDKD---GHIKITDFGLCKEGIKDGATMKTFCGTPE 314 ++YLH++K + + DLK EN+ +LDK+ HIK+ DFGL E I+DG K GTPE Sbjct: 126 DGVNYLHTKK-IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPE 183 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL-- 372 ++APE++ G D W +GV+ Y ++ G PF ++ I F Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFS 243 Query: 373 --GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 AK + LL K+ ++RL +E ++H + + Sbjct: 244 QTSELAKDFIRKLLVKETRKRL-----TIQEALRHPWITPVD 280 >3Q53-A nrPDB Length = 306 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 83/277 (29%), Positives = 141/277 (50%), Gaps = 18/277 (6%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 VS+ PK + + + +G+G G V + ATG+ A++ + + K+ Sbjct: 14 VSVGDPKKK-----YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKE---LI 65 Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 + E V++ +++P + S+ D L VMEY GG L + E E + Sbjct: 66 INEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD-VVTETCMDEGQIAAVCR 124 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEY 315 E + AL++LHS + V++RD+K +N++L DG +K+TDFG C + + + T GTP + Sbjct: 125 ECLQALEFLHSNQ-VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYW 183 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL---MEEIRFPRTL 372 +APEV+ YG VD W LG++ EM+ G P+ N++ + LI E++ P L Sbjct: 184 MAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKL 243 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + L+ L+ D ++R AKE++QH+F Sbjct: 244 SAIFRDFLNRCLEMDVEKR-----GSAKELIQHQFLK 275 >4XBR-A nrPDB Length = 366 Score = 264 bits (676), Expect = 5e-71, Method: Composition-based stats. Identities = 88/376 (23%), Positives = 169/376 (44%), Gaps = 35/376 (9%) Query: 40 ERPQDVDQREAPLNNFSVAQCQLMKTERP---RPNTFIIRCLQWTTVIERTFHVETPEER 96 + D D+ + +++ A ++ +P N F W +E PEE Sbjct: 2 DYKDDDDKSGSEAEDWTAALLNRGRSRQPLVLGDNCFADLVHNW---------MELPEEF 52 Query: 97 EEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLL 156 ++E + + A ++ V P+ ++ F + Sbjct: 53 PAAPAVPGPPGPRSPQREPQRVSHEQ-----FRAALQLVVDPGDPRSY--LDNFI---KI 102 Query: 157 GKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYS 216 G+G+ G V + +++G+ A+K + + + E ++++ +H + + S Sbjct: 103 GEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMYNS 159 Query: 217 FQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLK 276 + D L VME+ GG L + +E++ ++ AL LH++ V++RD+K Sbjct: 160 YLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIK 217 Query: 277 LENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG 336 ++++L DG +K++DFG C + K+ K+ GTP ++APE++ YG VD W LG Sbjct: 218 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLG 277 Query: 337 VVMYEMMCGRLPFYNQDHEKLFELI---LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 +++ EM+ G P++N+ K ++I L ++ + P K L LL +DP QR Sbjct: 278 IMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR-- 335 Query: 394 GGSEDAKEIMQHRFFA 409 A E+++H F A Sbjct: 336 ---ATAAELLKHPFLA 348 >1ZWS-A nrPDB Length = 288 Score = 264 bits (675), Expect = 6e-71, Method: Composition-based stats. Identities = 82/282 (29%), Positives = 136/282 (48%), Gaps = 18/282 (6%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE---VAHTLTE 198 K + + ++ + LG G F V +EK+TG YA K +KK A E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 +L+ H + L ++ + ++E +GGELF L+++ SE+ A + +I+ Sbjct: 66 VSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 259 SALDYLHSEKNVVYRDLKLENL-MLDKD---GHIKITDFGLCKEGIKDGATMKTFCGTPE 314 ++YLH++K + + DLK EN+ +LDK+ HIK+ DFGL E I+DG K GTPE Sbjct: 126 DGVNYLHTKK-IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE-IEDGVEFKNIFGTPE 183 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL-- 372 ++APE++ G D W +GV+ Y ++ G PF ++ I F Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFS 243 Query: 373 --GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 AK + LL K+ ++RL +E ++H + + Sbjct: 244 HTSELAKDFIRKLLVKETRKRL-----TIQEALRHPWITPVD 280 >6FDY-U nrPDB Length = 276 Score = 264 bits (675), Expect = 6e-71, Method: Composition-based stats. Identities = 80/268 (29%), Positives = 135/268 (50%), Gaps = 14/268 (5%) Query: 147 MNEFEYLKLLGKGTFGKVILVK-EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 ++ F + LG GT+ V +K T A+K + K+ + K V + LTE +L+ Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSL-NKASVENLLTEIEILKGI 68 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 RHP + LK D + +ME+ GG+L + R+ E AR + ++ SAL +LH Sbjct: 69 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 128 Query: 266 SEKNVVYRDLKLENLMLD--KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 E+N+ + DLK +N++L + H+K+ DFG + + G+P Y+APE++ Sbjct: 129 -ERNISHLDLKPQNILLSSLEKPHLKLADFGFA-QHMSPWDEKHVLRGSPLYMAPEMVCQ 186 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE-IRFP--RTLGPEAKSLL 380 Y VD W +GV++YE + G+ PF ++ +L E I I P L + + LL Sbjct: 187 RQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLL 246 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 LL++DP +R+ ++ H + Sbjct: 247 QRLLERDPSRRIS-----FQDFFAHPWV 269 >3GUB-A nrPDB Length = 295 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 81/294 (27%), Positives = 132/294 (44%), Gaps = 18/294 (6%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE---VAHTLTE 198 + + ++ + LG G F V +EK+TG YA K +KK + E Sbjct: 5 RQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIERE 64 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 +L+ +HP + L ++ + + E GGELF L+ + +E+ A + +I+ Sbjct: 65 VSILKEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQIL 124 Query: 259 SALDYLHSEKNVVYRDLKLENL-MLDKD---GHIKITDFGLCKEGIKDGATMKTFCGTPE 314 + + YLHS + + + DLK EN+ +LD++ IKI DFGL I G K GTPE Sbjct: 125 NGVYYLHSLQ-IAHFDLKPENIMLLDRNVPKPRIKIIDFGLA-HKIDFGNEFKNIFGTPE 182 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR---- 370 ++APE++ G D W +GV+ Y ++ G PF ++ + F Sbjct: 183 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFS 242 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPP 424 AK + LL KDPK+R+ ++ +QH + Q S P Sbjct: 243 NTSALAKDFIRRLLVKDPKKRM-----TIQDSLQHPWIKPKDTQQALSSAWSHP 291 >3I6U-A nrPDB Length = 419 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 93/292 (31%), Positives = 142/292 (48%), Gaps = 24/292 (8%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIV-----AKDEVAHTLTENRV 201 +E+ K LG G G+V L E+ T + A++I+ K D + TE + Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 L+ HP + +K F D V+E GGELF + + E + Y +++ A+ Sbjct: 194 LKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV 252 Query: 262 DYLHSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 YLH E +++RDLK EN++L +D IKITDFG K + + + M+T CGTP YLAP Sbjct: 253 QYLH-ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSK-ILGETSLMRTLCGTPTYLAP 310 Query: 319 EVL---EDNDYGRAVDWWGLGVVMYEMMCGRLPF-YNQDHEKLFELILMEEIRF-PR--- 370 EVL Y RAVD W LGV+++ + G PF ++ L + I + F P Sbjct: 311 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLS 422 + +A L+ LL DPK R +E ++H + + ++ LS Sbjct: 371 EVSEKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDEDMKRKFQDLLS 417 >2BPM-A nrPDB Length = 309 Score = 262 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 78/311 (25%), Positives = 131/311 (42%), Gaps = 40/311 (12%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 V M F+ ++ +G+GT+G V + K TG A+K ++ + + + + E +L+ Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKE 62 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSALD 262 HP + L T ++L V E+ +L + + Y +++ L Sbjct: 63 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 + HS + V++RDLK +NL+++ +G IK+ DFGL + T T Y APE+L Sbjct: 122 FCHSHR-VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 323 DND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDH-EKLFELILM----------------- 363 Y AVD W LG + EM+ R F ++LF + Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 240 Query: 364 EEIRFP-----------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 + FP L + +SLLS +L DP +R+ AK + H FF + Sbjct: 241 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDVT 295 Query: 413 WQHVYEKKLSP 423 + + P Sbjct: 296 KPVPHLRLERP 306 >4FIE-A nrPDB Length = 423 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 81/322 (25%), Positives = 152/322 (47%), Gaps = 21/322 (6%) Query: 91 ETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEF 150 P R + G + + E + S A ++ V P+ ++ F Sbjct: 102 PPPPARARQENGMPEKPPGPRSPQRE---PQRVSHEQFRAALQLVVDPGDPRSY--LDNF 156 Query: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 +G+G+ G V + +++G+ A+K + + + E ++++ +H + Sbjct: 157 I---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENV 210 Query: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNV 270 + S+ D L VME+ GG L + +E++ ++ AL LH++ V Sbjct: 211 VEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQ-GV 268 Query: 271 VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330 ++RD+K ++++L DG +K++DFG C + K+ K+ GTP ++APE++ YG V Sbjct: 269 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEV 328 Query: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELI---LMEEIRFPRTLGPEAKSLLSGLLKKD 387 D W LG+++ EM+ G P++N+ K ++I L ++ + P K L LL +D Sbjct: 329 DIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRD 388 Query: 388 PKQRLGGGSEDAKEIMQHRFFA 409 P QR A E+++H F A Sbjct: 389 PAQR-----ATAAELLKHPFLA 405 >4PDS-A nrPDB Length = 347 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 84/309 (27%), Positives = 145/309 (46%), Gaps = 29/309 (9%) Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYL-KLLGKGTFGKVILVKEKATGRYYAMK 179 + S + G S +F + +++G+G F V E+ TG+ +++K Sbjct: 3 MATSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVK 62 Query: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239 I+ K ++ + E VLQ HP + LK ++ + VME+ +GG+L + Sbjct: 63 IISKRKVIGNMDG--VTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFV 120 Query: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH--IKITDFGLCK 297 + ED R +I++A+ Y+HS + +RDLK +N+++++D +KIT FGL K Sbjct: 121 AAHGAVGEDAGREISRQILTAIKYIHS-MGISHRDLKPDNILIEQDDPVLVKITAFGLAK 179 Query: 298 EGIKDGATMKTFCGTPEYLAPEVLED-------------NDYGRAVDWWGLGVVMYEMMC 344 +G+ MKTFCGT Y+APEV+ N+Y VD W +G ++Y ++ Sbjct: 180 -VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILT 238 Query: 345 GRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 G LPF ++L++ I + EA+ + LL+ DP R A Sbjct: 239 GHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNR-----STAA 293 Query: 401 EIMQHRFFA 409 + + H + Sbjct: 294 KALNHPWIK 302 >2F57-A nrPDB Length = 317 Score = 261 bits (668), Expect = 4e-70, Method: Composition-based stats. Identities = 76/280 (27%), Positives = 140/280 (50%), Gaps = 18/280 (6%) Query: 133 EMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV 192 ++ VS P+ + ++K +G+G+ G V + EK TG+ A+K + + + Sbjct: 35 QLVVSPGDPREYLA----NFIK-IGEGSTGIVCIATEKHTGKQVAVKKMD---LRKQQRR 86 Query: 193 AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF 252 E ++++ H + + S+ D L VME+ GG L + +E++ Sbjct: 87 ELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAT 145 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT 312 ++ AL YLH++ V++RD+K ++++L DG IK++DFG C + K+ K+ GT Sbjct: 146 VCLSVLRALSYLHNQ-GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGT 204 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI---LMEEIRFP 369 P ++APEV+ YG VD W LG+++ EM+ G P++N+ + I L ++ Sbjct: 205 PYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDL 264 Query: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + + L +L ++P QR A+E++ H F Sbjct: 265 HKVSSVLRGFLDLMLVREPSQR-----ATAQELLGHPFLK 299 >1PHK-A nrPDB Length = 298 Score = 261 bits (667), Expect = 5e-70, Method: Composition-based stats. Identities = 87/288 (30%), Positives = 141/288 (48%), Gaps = 24/288 (8%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK------EVIVAKDEVAHTLTENRV 201 +E ++LG+G V K T + YA+KI+ ++ TL E + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 202 LQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 L+ HP + LK +++T+ V + GELF +L+ + SE R ++ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 + LH + N+V+RDLK EN++LD D +IK+TDFG + + G ++ CGTP YLAPE+ Sbjct: 137 ICALH-KLNIVHRDLKPENILLDDDMNIKLTDFGFSCQ-LDPGEKLREVCGTPSYLAPEI 194 Query: 321 LEDN------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRF--P--R 370 +E + YG+ VD W GV+MY ++ G PF+++ + +I+ +F P Sbjct: 195 IECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWD 254 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 418 K L+S L P++R A+E + H FF V + V Sbjct: 255 DYSDTVKDLVSRFLVVQPQKRY-----TAEEALAHPFFQQYVVEEVRH 297 >3KN6-A nrPDB Length = 325 Score = 261 bits (667), Expect = 6e-70, Method: Composition-based stats. Identities = 88/266 (33%), Positives = 132/266 (49%), Gaps = 22/266 (8%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTA 212 K LG+G+F K + + +A+KI+ K A+T E L+ HP + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK------RMEANTQKEITALKLCEGHPNIVK 70 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272 L F VME NGGELF + +++ FSE A + ++VSA+ ++H + VV+ Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVH 129 Query: 273 RDLKLENLML---DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 RDLK ENL+ + + IKI DFG + D +KT C T Y APE+L N Y + Sbjct: 130 RDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDES 189 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQDHE-------KLFELILMEEIRFP----RTLGPEAKS 378 D W LGV++Y M+ G++PF + D ++ + I + F + + EAK Sbjct: 190 CDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD 249 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQ 404 L+ GLL DP +RL E +Q Sbjct: 250 LIQGLLTVDPNKRLKMSGLRYNEWLQ 275 >2XIK-A nrPDB Length = 294 Score = 260 bits (665), Expect = 8e-70, Method: Composition-based stats. Identities = 85/277 (30%), Positives = 129/277 (46%), Gaps = 17/277 (6%) Query: 138 LAKPKHRVTMNE-FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 196 A RV E F L +GKG+FG+V + T A+KI+ ++ A+DE+ Sbjct: 8 FANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKII--DLEEAEDEIEDIQ 65 Query: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 E VL P++T S+ +L +MEY GG L + E E Sbjct: 66 QEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATILRE 124 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 316 I+ LDYLHSE+ + +RD+K N++L + G +K+ DFG+ + TF GTP ++ Sbjct: 125 ILKGLDYLHSERKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 183 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL---- 372 APEV++ + Y D W LG+ E+ G P + ++ LI P TL Sbjct: 184 APEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS---PPTLEGQH 240 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 K + L KDP+ R AKE+++H+F Sbjct: 241 SKPFKEFVEACLNKDPRFR-----PTAKELLKHKFIT 272 >5YV8-A nrPDB Length = 298 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 85/303 (28%), Positives = 140/303 (46%), Gaps = 37/303 (12%) Query: 137 SLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE------------ 184 S V +N++ +GKG++G V L + YYAMK+L K+ Sbjct: 2 SSGSSGDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRP 61 Query: 185 -----------VIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQT--HDRLCFVMEYAN 231 I + + E +L+ HP + L D L V E N Sbjct: 62 PPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVN 121 Query: 232 GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKIT 291 G + + + SED+ARFY +++ ++YLH +K +++RD+K NL++ +DGHIKI Sbjct: 122 QGPVME-VPTLKPLSEDQARFYFQDLIKGIEYLHYQK-IIHRDIKPSNLLVGEDGHIKIA 179 Query: 292 DFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND---YGRAVDWWGLGVVMYEMMCGRLP 348 DFG+ E A + GTP ++APE L + G+A+D W +GV +Y + G+ P Sbjct: 180 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 239 Query: 349 FYNQDHEKLFELILMEEIRFP--RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406 F ++ L I + + FP + + K L++ +L K+P+ R+ EI H Sbjct: 240 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHP 294 Query: 407 FFA 409 + Sbjct: 295 WVT 297 >2Q0N-A nrPDB Length = 301 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 75/280 (26%), Positives = 142/280 (50%), Gaps = 18/280 (6%) Query: 133 EMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV 192 ++ V P+ ++ F +G+G+ G V + +++G+ A+K + + + Sbjct: 19 QLVVDPGDPRSY--LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRR 70 Query: 193 AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF 252 E ++++ +H + + S+ D L VME+ GG L + +E++ Sbjct: 71 ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAA 129 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT 312 ++ AL LH++ V++RD+K ++++L DG +K++DFG C + K+ K+ GT Sbjct: 130 VCLAVLQALSVLHAQ-GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGT 188 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI---LMEEIRFP 369 P ++APE++ YG VD W LG+++ EM+ G P++N+ K ++I L ++ Sbjct: 189 PYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL 248 Query: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + P K L LL +DP QR A E+++H F A Sbjct: 249 HKVSPSLKGFLDRLLVRDPAQR-----ATAAELLKHPFLA 283 >4KS7-A nrPDB Length = 292 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 75/283 (26%), Positives = 147/283 (51%), Gaps = 18/283 (6%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA 188 A M V P R+ ++ + +G+G+ G V L +EK +GR A+K++ + Sbjct: 9 KAALRMVVDQGDP--RLLLDSYV---KIGEGSTGIVCLAREKHSGRQVAVKMMD---LRK 60 Query: 189 KDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED 248 + E ++++ +H + + S+ + L +ME+ GG L +S+ R +E+ Sbjct: 61 QQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVR-LNEE 119 Query: 249 RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT 308 + ++ AL YLH++ V++RD+K ++++L DG +K++DFG C + KD K+ Sbjct: 120 QIATVCEAVLQALAYLHAQ-GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKS 178 Query: 309 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM---EE 365 GTP ++APEV+ + Y VD W LG+++ EM+ G P+++ + + + + Sbjct: 179 LVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPK 238 Query: 366 IRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 ++ + P + L +L +DP++R A+E++ H F Sbjct: 239 LKNSHKVSPVLRDFLERMLVRDPQER-----ATAQELLDHPFL 276 >2Y7J-A nrPDB Length = 365 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 86/335 (25%), Positives = 159/335 (47%), Gaps = 32/335 (9%) Query: 91 ETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEF 150 + P + + + D + + E + F+S P D + ++ Sbjct: 46 DDPSQSANLLAEAKKLNDA-QPKGTENLYFQSMGPEDELPDWAAAKEFYQ--------KY 96 Query: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKIL-----KKEVIVAKDEVAHTLTENRVLQNS 205 + ++G+G V +ATG +A+KI+ + ++ T E +L+ Sbjct: 97 DPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQV 156 Query: 206 -RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 HP + L S+++ + V + GELF +L+ + SE R ++ A+ +L Sbjct: 157 AGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFL 216 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 H+ N+V+RDLK EN++LD + I+++DFG ++ G ++ CGTP YLAPE+L+ + Sbjct: 217 HAN-NIVHRDLKPENILLDDNMQIRLSDFGFS-CHLEPGEKLRELCGTPGYLAPEILKCS 274 Query: 325 ------DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----RTLGP 374 YG+ VD W GV+++ ++ G PF+++ + +I+ + +F Sbjct: 275 MDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSS 334 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 K L+S LL+ DP+ RL A++ +QH FF Sbjct: 335 TVKDLISRLLQVDPEARL-----TAEQALQHPFFE 364 >4JDH-A nrPDB Length = 346 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 79/317 (24%), Positives = 147/317 (46%), Gaps = 32/317 (10%) Query: 110 LKKQEEEEMDFRSGSPSDNSGAEEME--------------VSLAKPKHRVTMNEFEYLKL 155 + +E P S E + V P+ ++ F Sbjct: 27 QGARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSY--LDNFI---K 81 Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G+G+ G V + +++G+ A+K + + + E ++++ +H + + Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMYN 138 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 S+ D L VME+ GG L + +E++ ++ AL LH++ V++RD+ Sbjct: 139 SYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQ-GVIHRDI 196 Query: 276 KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 K ++++L DG +K++DFG C + K+ K+ GTP ++APE++ YG VD W L Sbjct: 197 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSL 256 Query: 336 GVVMYEMMCGRLPFYNQDHEKLFELI---LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 G+++ EM+ G P++N+ K ++I L ++ + P K L LL +DP QR Sbjct: 257 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR- 315 Query: 393 GGGSEDAKEIMQHRFFA 409 A E+++H F A Sbjct: 316 ----ATAAELLKHPFLA 328 >4XEY-B nrPDB Length = 408 Score = 257 bits (658), Expect = 5e-69, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 121/303 (39%), Gaps = 21/303 (6%) Query: 99 WTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGK 158 +T + L + S N EME + KH+ LG Sbjct: 87 HSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHK-----------LGG 135 Query: 159 GTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQ 218 G +G+V K A+K LK++ + EV L E V++ +HP L L Sbjct: 136 GQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLGVCT 191 Query: 219 THDRLCFVMEYANGGELFFHLS--RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLK 276 + E+ G L +L + + + +I SA++YL +KN ++RDL Sbjct: 192 REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL-EKKNFIHRDLA 250 Query: 277 LENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGL 335 N ++ ++ +K+ DFGL + D T P ++ APE L N + D W Sbjct: 251 ARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAF 310 Query: 336 GVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 GV+++E+ G P+ D +++EL+ + + P + L+ + +P R Sbjct: 311 GVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPS 370 Query: 394 GGS 396 Sbjct: 371 FAE 373 >4APC-A nrPDB Length = 350 Score = 257 bits (658), Expect = 5e-69, Method: Composition-based stats. Identities = 92/325 (28%), Positives = 159/325 (48%), Gaps = 22/325 (6%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +M ++ L+ +G+G+FGK ILVK GR Y +K + + +K E + E VL N Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSK-EREESRREVAVLANM 80 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEIVSALDY 263 +HP + + SF+ + L VM+Y GG+LF ++ ++ F ED+ + +I AL + Sbjct: 81 KHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKH 140 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 +H K +++RD+K +N+ L KDG +++ DFG+ + + GTP YL+PE+ E+ Sbjct: 141 VHDRK-ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICEN 199 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR---TLGPEAKSLL 380 Y D W LG V+YE+ + F + L I+ FP + +SL+ Sbjct: 200 KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGS--FPPVSLHYSYDLRSLV 257 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 S L K++P+ R I++ F A + EK LSP E + F + Sbjct: 258 SQLFKRNPRDR-----PSVNSILEKGFIAKRI-----EKFLSPQLI---AEEFCLKTFSK 304 Query: 441 EFTAQMITITPPDQDDSMECVDSER 465 + + P +S+ + +++ Sbjct: 305 FGSQPIPAKRPASGQNSISVMPAQK 329 >6HXF-B nrPDB Length = 302 Score = 257 bits (658), Expect = 6e-69, Method: Composition-based stats. Identities = 78/301 (25%), Positives = 147/301 (48%), Gaps = 20/301 (6%) Query: 142 KHRVTMNE-FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 + + NE +E + LG G FGKV K K TG A K+++ + +++E+ + E Sbjct: 12 RRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETK---SEEELEDYIVEIE 68 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH-LSRERVFSEDRARFYGAEIVS 259 +L HP++ L ++ +L ++E+ GG + L +R +E + + +++ Sbjct: 69 ILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLE 128 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 AL++LHS++ +++RDLK N+++ +G I++ DFG+ + +K +F GTP ++APE Sbjct: 129 ALNFLHSKR-IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 187 Query: 320 VLE-----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIR---FPRT 371 V+ D Y D W LG+ + EM P + + ++ I + P Sbjct: 188 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSK 247 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTS 431 E + L L K+P+ R A ++++H F + I + ++L K +V Sbjct: 248 WSVEFRDFLKIALDKNPETR-----PSAAQLLEHPFVSSIT-SNKALRELVAEAKAEVME 301 Query: 432 E 432 E Sbjct: 302 E 302 >2FO0-A nrPDB Length = 495 Score = 257 bits (656), Expect = 9e-69, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 121/303 (39%), Gaps = 21/303 (6%) Query: 99 WTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGK 158 +T + L + S N EME + KH+ LG Sbjct: 179 HSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHK-----------LGG 227 Query: 159 GTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQ 218 G +G+V K A+K LK++ + EV L E V++ +HP L L Sbjct: 228 GQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLGVCT 283 Query: 219 THDRLCFVMEYANGGELFFHLS--RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLK 276 + E+ G L +L + + + +I SA++YL +KN ++R+L Sbjct: 284 REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL-EKKNFIHRNLA 342 Query: 277 LENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGL 335 N ++ ++ +K+ DFGL + D T P ++ APE L N + D W Sbjct: 343 ARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAF 402 Query: 336 GVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 GV+++E+ G P+ D +++EL+ + + P + L+ + +P R Sbjct: 403 GVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPS 462 Query: 394 GGS 396 Sbjct: 463 FAE 465 >4FZF-B nrPDB Length = 283 Score = 257 bits (656), Expect = 9e-69, Method: Composition-based stats. Identities = 78/260 (30%), Positives = 119/260 (45%), Gaps = 10/260 (3%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F L+ +GKG+FG+V + T + A+KI+ E + E E VL + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSY 67 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 +T S+ +L +MEY GG L R F E + EI+ LDYLHSEK Sbjct: 68 VTKYYGSYLKGSKLWIIMEYLGGGSALDLL-RAGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 + +RD+K N++L + G +K+ FG+ + TF GTP ++APEV++ + Y Sbjct: 127 I-HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK 185 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI-LMEEIRFPRTLGPEAKSLLSGLLKKDP 388 D W LG+ E+ G P + ++ LI K + L KDP Sbjct: 186 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDP 245 Query: 389 KQRLGGGSEDAKEIMQHRFF 408 R AKE+++H+F Sbjct: 246 SFR-----PTAKELLKHKFI 260 >1CM8-A nrPDB Length = 367 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 88/358 (24%), Positives = 142/358 (39%), Gaps = 64/358 (17%) Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180 S P SG EV+ + R + L+ +G G +G V + TG A+K Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAV---YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKK 57 Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL------CFVMEYANGGE 234 L + ++ E R+L++ RH + L F + L VM + G Sbjct: 58 LYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GT 114 Query: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 L + EDR +F +++ L Y+H+ +++RDLK NL +++D +KI DFG Sbjct: 115 DLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVNEDCELKILDFG 173 Query: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353 L ++ + M + T Y APEV+ + Y + VD W +G +M EM+ G+ F D Sbjct: 174 LARQADSE---MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 Query: 354 HEKLFELILMEEIRFPRTL-------------------------------GPEAKSLLSG 382 H + I+ P P A +LL Sbjct: 231 HLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEK 290 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 +L D +QR+ A E + H +F + +PQV D+ FD+ Sbjct: 291 MLVLDAEQRV-----TAGEALAHPYFESLH---------DTEDEPQVQKYDDS--FDD 332 >2UV2-A nrPDB Length = 325 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 73/271 (26%), Positives = 125/271 (46%), Gaps = 18/271 (6%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + +E + LG G FGKV + K T A K++ + +++E+ + E +L + H Sbjct: 37 DFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTK---SEEELEDYMVEIDILASCDH 93 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELF-FHLSRERVFSEDRARFYGAEIVSALDYLHS 266 P + L +F + L ++E+ GG + L ER +E + + + + AL+YLH Sbjct: 94 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 153 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE---- 322 K +++RDLK N++ DG IK+ DFG+ + + +F GTP ++APEV+ Sbjct: 154 NK-IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETS 212 Query: 323 -DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPRTLGPEAKS 378 D Y D W LG+ + EM P + + ++ I E + P K Sbjct: 213 KDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKD 272 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 L L+K+ R +++QH F Sbjct: 273 FLKKCLEKNVDARW-----TTSQLLQHPFVT 298 >2XYN-A nrPDB Length = 292 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 69/270 (25%), Positives = 113/270 (41%), Gaps = 11/270 (4%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K + + LG G +G+V + K A+K LK++ + EV L E V Sbjct: 26 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM----EVEEFLKEAAV 81 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS--RERVFSEDRARFYGAEIVS 259 ++ +HP L L V EY G L +L + + +I S Sbjct: 82 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 141 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAP 318 A++YL +KN ++RDL N ++ ++ +K+ DFGL + D T P ++ AP Sbjct: 142 AMEYL-EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 200 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEA 376 E L N + D W GV+++E+ G P+ D ++++L+ + P P+ Sbjct: 201 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 260 Query: 377 KSLLSGLLKKDPKQRLGGGSE-DAKEIMQH 405 L+ K P R A E M H Sbjct: 261 YELMRACWKWSPADRPSFAETHQAFETMFH 290 >3PPZ-A nrPDB Length = 309 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 67/262 (25%), Positives = 123/262 (46%), Gaps = 11/262 (4%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 + + +G G+FG V + G A+KIL ++ A+ V L E +++ RHP Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAER-VNEFLREVAIMKRLRHP 94 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSR---ERVFSEDRARFYGAEIVSALDYLH 265 + + L V EY + G L+ L + E R ++ ++YLH Sbjct: 95 NIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLH 154 Query: 266 SEKN-VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 + +V+RDLK NL++DK +K+ DFGL + + K+ GTPE++APEVL D Sbjct: 155 NRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDE 214 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI--LMEEIRFPRTLGPEAKSLLSG 382 D + GV+++E+ + P+ N + ++ + + + PR L P+ +++ G Sbjct: 215 PSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEG 274 Query: 383 LLKKDPKQRLGGGSEDAKEIMQ 404 +P +R ++++ Sbjct: 275 CWTNEPWKRPSFA--TIMDLLR 294 >6NPU-A nrPDB Length = 298 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 71/285 (24%), Positives = 120/285 (42%), Gaps = 23/285 (8%) Query: 117 EMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYY 176 E + GSP N EME + KH+ LG G +G+V K Sbjct: 8 ENLYFQGSP--NYDKWEMERTDITMKHK-----------LGGGQYGEVYEGVWKKYSLTV 54 Query: 177 AMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELF 236 A+K LK++ + EV L E V++ +HP L L + E+ G L Sbjct: 55 AVKTLKEDTM----EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL 110 Query: 237 FHLS--RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 +L + + + +I SA++YL +KN ++RDL N ++ ++ +K+ DFG Sbjct: 111 DYLRECNRQEVNAVVLLYMATQISSAMEYL-EKKNFIHRDLAARNCLVGENHLVKVADFG 169 Query: 295 LCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ 352 L + D T P ++ APE L N + D W GV+++E+ G P+ Sbjct: 170 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGI 229 Query: 353 DHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGS 396 D +++EL+ + + P + L+ + +P R Sbjct: 230 DLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAE 274 >3IS5-A nrPDB Length = 285 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 86/275 (31%), Positives = 137/275 (49%), Gaps = 21/275 (7%) Query: 146 TMNE-FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 T+++ F + + LG G FG V LV+E+++G +K + K+ ++ + E VL++ Sbjct: 19 TIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDR--SQVPMEQIEAEIEVLKS 76 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS----RERVFSEDRARFYGAEIVSA 260 HP + + F+ + + VME GGEL + R + SE ++++A Sbjct: 77 LDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNA 136 Query: 261 LDYLHSEKNVVYRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 L Y HS+ +VV++DLK EN++ IKI DFGL E K GT Y+A Sbjct: 137 LAYFHSQ-HVVHKDLKPENILFQDTSPHSPIKIIDFGLA-ELFKSDEHSTNAAGTALYMA 194 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGP 374 PEV + D D W GVVMY ++ G LPF E++ + +E + R L P Sbjct: 195 PEVFK-RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTP 253 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 +A LL +L KDP++R A +++ H +F Sbjct: 254 QAVDLLKQMLTKDPERR-----PSAAQVLHHEWFK 283 >3DAK-A nrPDB Length = 290 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 123/291 (42%), Gaps = 32/291 (10%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + +++E +++G G V A+K + E + L E + + Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMD--ELLKEIQAM 62 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL--------SRERVFSEDRARFYG 254 HP + + SF D L VM+ +GG + + + V E Sbjct: 63 SQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATIL 122 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG-----IKDGATMKTF 309 E++ L+YLH + ++RD+K N++L +DG ++I DFG+ I KTF Sbjct: 123 REVLEGLEYLH-KNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTF 181 Query: 310 CGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI-- 366 GTP ++APEV+E Y D W G+ E+ G P++ K+ L L + Sbjct: 182 VGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPS 241 Query: 367 --------RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + G + ++S L+KDP++R A E+++H+FF Sbjct: 242 LETGVQDKEMLKKYGKSFRKMISLCLQKDPEKR-----PTAAELLRHKFFQ 287 >4AGU-A nrPDB Length = 311 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 75/311 (24%), Positives = 124/311 (39%), Gaps = 41/311 (13%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 M ++E + +G+G++G V + + TG+ A+K E L E R+L+ + Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF-LESEDDPVIKKIALREIRMLKQLK 60 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP L L F+ RL V EY + L +R E + + + A+++ H Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH- 119 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED-ND 325 + N ++RD+K EN+++ K IK+ DFG + T Y +PE+L Sbjct: 120 KHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQ 179 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME--------------------- 364 YG VD W +G V E++ G + + LI Sbjct: 180 YGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGV 239 Query: 365 -----------EIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413 E++FP + A LL G L DP +RL ++++ H +F I Sbjct: 240 KIPDPEDMEPLELKFP-NISYPALGLLKGCLHMDPTERLTC-----EQLLHHPYFENIRE 293 Query: 414 QHVYEKKLSPP 424 K+ P Sbjct: 294 IEDLAKEHDKP 304 >2X4F-A nrPDB Length = 373 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 89/328 (27%), Positives = 148/328 (45%), Gaps = 28/328 (8%) Query: 94 EEREEWTTA--IQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFE 151 E +E W+ A + + K+ +D + + + K + + Sbjct: 38 EAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAP-------FDHRIVTAKQGAVNSFYT 90 Query: 152 YLK--LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 K +LG G FG+V +E ATG A KI+K + K+EV E V+ H Sbjct: 91 VSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVK---NEISVMNQLDHAN 147 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLHSEK 268 L L +F++ + + VMEY +GGELF + E +E + +I + ++H + Sbjct: 148 LIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMH-QM 206 Query: 269 NVVYRDLKLENLM-LDKDG-HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 +++ DLK EN++ +++D IKI DFGL + K +K GTPE+LAPEV+ + Sbjct: 207 YILHLDLKPENILCVNRDAKQIKIIDFGLARR-YKPREKLKVNFGTPEFLAPEVVNYDFV 265 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLLSG 382 D W +GV+ Y ++ G PF + + IL + EAK +S Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISK 325 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 LL K+ R+ A E ++H + + Sbjct: 326 LLIKEKSWRIS-----ASEALKHPWLSD 348 >3TT0-A nrPDB Length = 382 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 71/317 (22%), Positives = 133/317 (41%), Gaps = 40/317 (12%) Query: 116 EEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR- 174 E + G +G E E+ P+ + + K LG+G FG+V+L + + Sbjct: 41 TENLYFQG---MLAGVSEYELP-EDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKD 96 Query: 175 ------YYAMKILKKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVM 227 A+K+LK + + +++ ++E +++ +H + L + L ++ Sbjct: 97 KPNRVTKVAVKMLKSDA--TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 154 Query: 228 EYANGGELFFHLSRERV----------------FSEDRARFYGAEIVSALDYLHSEKNVV 271 EYA+ G L +L R S ++ ++YL S+K + Sbjct: 155 EYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK-CI 213 Query: 272 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRA 329 +RDL N+++ +D +KI DFGL ++ KT G +++APE L D Y Sbjct: 214 HRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ 273 Query: 330 VDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKD 387 D W GV+++E+ G P+ E+LF+L+ + P E ++ Sbjct: 274 SDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV 333 Query: 388 PKQRLGGGSEDAKEIMQ 404 P QR K++++ Sbjct: 334 PSQR-----PTFKQLVE 345 >5D7A-A nrPDB Length = 308 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 80/317 (25%), Positives = 141/317 (44%), Gaps = 34/317 (10%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA 188 SGA+E+++S + + FE ++L+G GT+G+V + TG+ A+K++ V Sbjct: 2 SGADEIDLSALRDPAGI----FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD----VT 53 Query: 189 KDEVAHTLTENRVLQN-SRHPFLTALKYSFQTH------DRLCFVMEYANGGELFFHLS- 240 DE E +L+ S H + +F D+L VME+ G + + Sbjct: 54 GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN 113 Query: 241 -RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299 + E+ + EI+ L +LH K V++RD+K +N++L ++ +K+ DFG+ + Sbjct: 114 TKGNTLKEEWIAYICREILRGLSHLHQHK-VIHRDIKGQNVLLTENAEVKLVDFGVSAQL 172 Query: 300 IKDGATMKTFCGTPEYLAPEVLE-----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354 + TF GTP ++APEV+ D Y D W LG+ EM G P + Sbjct: 173 DRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHP 232 Query: 355 EKLFELI-LMEEIRF-PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 + LI R + + +S + L K+ QR +++M+H F Sbjct: 233 MRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQR-----PATEQLMKHPFIR--- 284 Query: 413 WQHVYEKKLSPPFKPQV 429 E+++ K + Sbjct: 285 -DQPNERQVRIQLKDHI 300 >4BBM-A nrPDB Length = 331 Score = 251 bits (642), Expect = 4e-67, Method: Composition-based stats. Identities = 74/309 (23%), Positives = 123/309 (39%), Gaps = 39/309 (12%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +M ++E L L+G+G++G V+ + K TGR A+K E K + E ++L+ Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKF-LESDDDKMVKKIAMREIKLLKQL 81 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 RH L L + R V E+ + L + Y +I++ + + H Sbjct: 82 RHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCH 141 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN- 324 S N+++RD+K EN+++ + G +K+ DFG + G T Y APE+L + Sbjct: 142 SH-NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDV 200 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME-------------------E 365 YG+AVD W +G ++ EM G F I+M Sbjct: 201 KYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAG 260 Query: 366 IRFP------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413 +R P L L L DP +R E++ H FF + Sbjct: 261 VRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKR-----PFCAELLHHDFFQMDGF 315 Query: 414 QHVYEKKLS 422 + ++L Sbjct: 316 AERFSQELQ 324 >3NIZ-A nrPDB Length = 311 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 121/297 (40%), Gaps = 39/297 (13%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 M +++ L+ +G+GT+G V K+ GR A+K ++ + + + + E +L+ Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDA-EDEGIPSTAIREISLLKELH 77 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 HP + +L + L V E+ + + + + Y +++ + + H Sbjct: 78 HPNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQ 137 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED-ND 325 + +++RDLK +NL+++ DG +K+ DFGL + + T Y AP+VL Sbjct: 138 HR-ILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-----------EEIRFP----- 369 Y +VD W +G + EM+ G+ F + I + P Sbjct: 197 YSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR 256 Query: 370 --------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 E LLS +L DP +R+ A++ M H +F + Sbjct: 257 TFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRIS-----ARDAMNHPYFKDLD 308 >5A46-A nrPDB Length = 386 Score = 251 bits (640), Expect = 8e-67, Method: Composition-based stats. Identities = 80/364 (21%), Positives = 147/364 (40%), Gaps = 43/364 (11%) Query: 122 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR------- 174 S +G E E+ P+ + + K LG+G FG+V+L + + Sbjct: 15 SSGTPMLAGVSEYELP-EDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 73 Query: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGG 233 A+K+LK + + +++ ++E +++ +H + L + L ++EYA+ G Sbjct: 74 KVAVKMLKSDA--TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 131 Query: 234 ELFFHLSRERV----------------FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKL 277 L +L R S ++ ++YL S+K ++RDL Sbjct: 132 NLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK-CIHRDLAA 190 Query: 278 ENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGL 335 N+++ +D +KI DFGL ++ KT G +++APE L D Y D W Sbjct: 191 RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 250 Query: 336 GVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 GV+++E+ G P+ E+LF+L+ + P E ++ P QR Sbjct: 251 GVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR-- 308 Query: 394 GGSEDAKEIMQ--HRFFAGIVWQHVYEKKLS----PPFKPQVTSETDTRYFDEEFTAQMI 447 K++++ R A Q + + P P S T + D F+ + + Sbjct: 309 ---PTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPL 365 Query: 448 TITP 451 P Sbjct: 366 PEEP 369 >4KRC-A nrPDB Length = 317 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 132/303 (43%), Gaps = 50/303 (16%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++F+ L+ LG GT+ V K TG Y A+K +K + + + + E +++ +H Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELKH 62 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE------RVFSEDRARFYGAEIVSAL 261 + L T ++L V E+ + +L ++ R + +++ +++ L Sbjct: 63 ENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 + H K +++RDLK +NL+++K G +K+ DFGL + T + T Y AP+VL Sbjct: 122 AFCHENK-ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 Query: 322 ED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI------------------- 361 Y ++D W G ++ EM+ G+ F + E+ +LI Sbjct: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 Query: 362 ---LMEEIRFPRTLGPEAK------------SLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406 + R PR L + L GLL+ +P RL AK+ + H Sbjct: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS-----AKQALHHP 295 Query: 407 FFA 409 +FA Sbjct: 296 WFA 298 >3UTO-A nrPDB Length = 573 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 80/298 (26%), Positives = 134/298 (44%), Gaps = 20/298 (6%) Query: 123 GSPSDNSGAEEMEVSLAKP---KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMK 179 S DN + + +P KH ++ ++ + LG G FG V V E+ATG +A K Sbjct: 129 SSNYDNYVFDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAK 188 Query: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239 + K+ V E + + RHP L L +F+ + + + E+ +GGELF + Sbjct: 189 FVMTPHESDKETVR---KEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKV 245 Query: 240 -SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD--KDGHIKITDFGLC 296 SED A Y ++ L ++H E N V+ DLK EN+M + +K+ DFGL Sbjct: 246 ADEHNKMSEDEAVEYMRQVCKGLCHMH-ENNYVHLDLKPENIMFTTKRSNELKLIDFGL- 303 Query: 297 KEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEK 356 + ++K GT E+ APEV E G D W +GV+ Y ++ G PF ++ ++ Sbjct: 304 TAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDE 363 Query: 357 LFELILMEEIRFPRT----LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 + + + + + K + LL DP R+ + ++H + Sbjct: 364 TLRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRM-----TIHQALEHPWLTP 416 >3GQL-A nrPDB Length = 326 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 130/304 (42%), Gaps = 37/304 (12%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR-------YYAMKIL 181 +G E E+ P+ + + K LG+G FG+V+L + + A+K+L Sbjct: 10 AGVSEYELP-EDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML 68 Query: 182 KKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240 K + + +++ ++E +++ +H + L + L ++EYA+ G L +L Sbjct: 69 KSDA--TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQ 126 Query: 241 RERV----------------FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 R S ++ ++YL S+K ++RDL N+++ + Sbjct: 127 ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK-CIHRDLAARNVLVTE 185 Query: 285 DGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 D +KI DFGL ++ KT G +++APE L D Y D W GV+++E+ Sbjct: 186 DNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEI 245 Query: 343 MC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 G P+ E+LF+L+ + P E ++ P QR K Sbjct: 246 FTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR-----PTFK 300 Query: 401 EIMQ 404 ++++ Sbjct: 301 QLVE 304 >6GU6-A nrPDB Length = 302 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 125/300 (41%), Gaps = 41/300 (13%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +M ++ ++ +G+GT+G V + K TG+ AMK ++ E + + + E +L+ Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKEL 63 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR---ERVFSEDRARFYGAEIVSALD 262 RHP + +L+ RL + E+ + +L +L + + Y +I+ + Sbjct: 64 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 + HS + V++RDLK +NL++D G IK+ DFGL + T Y +PEVL Sbjct: 123 FCHSRR-VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 181 Query: 323 DN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME----------------- 364 + Y VD W +G + E+ + F+ I Sbjct: 182 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 241 Query: 365 -EIRFPRT-----------LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 + FP+ L LLS +L DP +R+ G K + H +F + Sbjct: 242 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDLD 296 >3V5Q-A nrPDB Length = 297 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 107/275 (38%), Gaps = 29/275 (10%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKE-----KATGRYYAMKILKKEVIVAKDEVAHTLT 197 + + + LG+G FGKV L + A+K LK + A+ + Sbjct: 10 QHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD---FQR 66 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV------------- 244 E +L N +H + D L V EY G+L L Sbjct: 67 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 126 Query: 245 ---FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 + ++I S + YL S+ + V+RDL N ++ + +KI DFG+ ++ Sbjct: 127 KGELGLSQMLHIASQIASGMVYLASQ-HFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS 185 Query: 302 DGATMKTFCGTP--EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLF 358 ++ PE + + D W GV+++E+ G+ P++ + ++ Sbjct: 186 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 245 Query: 359 ELILMEE-IRFPRTLGPEAKSLLSGLLKKDPKQRL 392 E I + PR E ++ G +++P+QRL Sbjct: 246 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRL 280 >2WQN-A nrPDB Length = 310 Score = 247 bits (631), Expect = 8e-66, Method: Composition-based stats. Identities = 66/254 (25%), Positives = 118/254 (46%), Gaps = 9/254 (3%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 T+ F K +G+G F +V G A+K ++ ++ A + E +L+ Sbjct: 30 TLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL 89 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS----RERVFSEDRARFYGAEIVSAL 261 HP + SF + L V+E A+ G+L + ++R+ E Y ++ SAL Sbjct: 90 NHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +++HS + V++RD+K N+ + G +K+ D GL + + GTP Y++PE + Sbjct: 150 EHMHSRR-VMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYN--QDHEKLFELILMEEIR--FPRTLGPEAK 377 +N Y D W LG ++YEM + PFY + L + I + E + Sbjct: 209 HENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELR 268 Query: 378 SLLSGLLKKDPKQR 391 L++ + DP++R Sbjct: 269 QLVNMCINPDPEKR 282 >3DTC-A nrPDB Length = 271 Score = 247 bits (631), Expect = 8e-66, Method: Composition-based stats. Identities = 68/263 (25%), Positives = 117/263 (44%), Gaps = 18/263 (6%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE-VAHTLTENRVL 202 + E +++G G FGKV G A+K + + + + + E ++ Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLF 60 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 +HP + AL+ LC VME+A GG L LS +R D + +I ++ Sbjct: 61 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR-IPPDILVNWAVQIARGMN 119 Query: 263 YLHSEK--NVVYRDLKLENLMLD--------KDGHIKITDFGLCKEGIKDGATMKTFCGT 312 YLH E +++RDLK N+++ + +KITDFGL +E + T + G Sbjct: 120 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHR--TTKMSAAGA 177 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE--IRFPR 370 ++APEV+ + + + D W GV+++E++ G +PF D + + M + + P Sbjct: 178 YAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 237 Query: 371 TLGPEAKSLLSGLLKKDPKQRLG 393 T L+ DP R Sbjct: 238 TCPEPFAKLMEDCWNPDPHSRPS 260 >1KOA-A nrPDB Length = 491 Score = 247 bits (630), Expect = 9e-66, Method: Composition-based stats. Identities = 80/298 (26%), Positives = 134/298 (44%), Gaps = 20/298 (6%) Query: 123 GSPSDNSGAEEMEVSLAKP---KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMK 179 S DN + + +P KH ++ ++ + LG G FG V V E+ATG +A K Sbjct: 23 SSNYDNYVFDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAK 82 Query: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239 + K+ V E + + RHP L L +F+ + + + E+ +GGELF + Sbjct: 83 FVMTPHESDKETVR---KEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKV 139 Query: 240 -SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD--KDGHIKITDFGLC 296 SED A Y ++ L ++H E N V+ DLK EN+M + +K+ DFGL Sbjct: 140 ADEHNKMSEDEAVEYMRQVCKGLCHMH-ENNYVHLDLKPENIMFTTKRSNELKLIDFGL- 197 Query: 297 KEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEK 356 + ++K GT E+ APEV E G D W +GV+ Y ++ G PF ++ ++ Sbjct: 198 TAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDE 257 Query: 357 LFELILMEEIRFPRT----LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 + + + + + K + LL DP R+ + ++H + Sbjct: 258 TLRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRM-----TIHQALEHPWLTP 310 >4UY9-A nrPDB Length = 323 Score = 247 bits (630), Expect = 9e-66, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 128/303 (42%), Gaps = 29/303 (9%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDE-VAHTLTENRVL 202 + E +++G G FGKV G A+K + + + + + E ++ Sbjct: 5 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLF 62 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 +HP + AL+ LC VME+A GG L LS +R D + +I ++ Sbjct: 63 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR-IPPDILVNWAVQIARGMN 121 Query: 263 YLHSEK--NVVYRDLKLENLMLD--------KDGHIKITDFGLCKEGIKDGATMKTFCGT 312 YLH E +++RDLK N+++ + +KITDFGL +E + T + GT Sbjct: 122 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHR--TTKMSAAGT 179 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE--IRFPR 370 ++APEV+ + + + D W GV+++E++ G +PF D + + M + + P Sbjct: 180 YAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 239 Query: 371 TLGPEAKSLLSGLLKKDPKQR--LGGGSEDAKEIMQHRFFA---------GIVWQHVYEK 419 T L+ DP R + I + FF W+H ++ Sbjct: 240 TCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQE 299 Query: 420 KLS 422 Sbjct: 300 MFD 302 >5DBX-A nrPDB Length = 328 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 78/312 (25%), Positives = 127/312 (40%), Gaps = 34/312 (10%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + + +E +++G G V K A+K + E + L E + + Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMD--ELLKEIQAM 63 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL--------SRERVFSEDRARFYG 254 HP + SF D L VM+ +GG + + + V E Sbjct: 64 SQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIL 123 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG-----IKDGATMKTF 309 E++ LDYLH ++RDLK N++L +DG ++I DFG+ + K F Sbjct: 124 KEVLEGLDYLH-RNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDF 182 Query: 310 CGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI-- 366 GTP ++APEV+E Y D W G+ E+ G P++ K+ L L + Sbjct: 183 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPT 242 Query: 367 --------RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI-VWQHVY 417 + G + LLS L+KDP +R A E+++ +FF +++ Sbjct: 243 LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKR-----PTAAELLKCKFFQKAKNREYLI 297 Query: 418 EKKLS-PPFKPQ 428 EK L+ P Q Sbjct: 298 EKLLTRTPDIAQ 309 >6CQF-A nrPDB Length = 297 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 127/275 (46%), Gaps = 17/275 (6%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 +R + ++ L+ LG GT+G+V ++K +G A+K++K + D+V+ E +L Sbjct: 11 NRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK---MEPDDDVSTLQKEILIL 67 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + RH + A S+ +L ME+ G L SE + + E++ L Sbjct: 68 KTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLA 127 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE--- 319 YLHS+K + +RD+K N++++ G +++ DFG+ + A F GTP ++APE Sbjct: 128 YLHSQKKI-HRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAA 186 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR-----TLGP 374 V Y D W LG+ E+ + P ++ ++ L+ + PR Sbjct: 187 VALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSA 246 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + + L K PK+R A +++ H+ + Sbjct: 247 AFHNFIKVTLTKSPKKR-----PSATKMLSHQLVS 276 >5AMN-A nrPDB Length = 299 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 76/287 (26%), Positives = 130/287 (45%), Gaps = 24/287 (8%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILV-----KEKATGRYYAMKILKKEVIVAKDEV 192 L PK K LG+G FGKV+ K +A A+K+LK+ + E+ Sbjct: 13 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSEL 70 Query: 193 AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR----------E 242 L+E VL+ HP + L + L ++EYA G L L E Sbjct: 71 RDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDE 130 Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD 302 R + + +I + YL +E +V+RDL N+++ + +KI+DFGL ++ ++ Sbjct: 131 RALTMGDLISFAWQISQGMQYL-AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE 189 Query: 303 GATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFE 359 + +K G +++A E L D+ Y D W GV+++E++ G P+ E+LF Sbjct: 190 DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFN 249 Query: 360 LILME-EIRFPRTLGPEAKSLLSGLLKKDPKQR--LGGGSEDAKEIM 403 L+ + P E L+ K++P +R S+D +++M Sbjct: 250 LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 296 >4WNO-A nrPDB Length = 287 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 78/278 (28%), Positives = 129/278 (46%), Gaps = 24/278 (8%) Query: 146 TMNEFEYLKL--LGKGTFGKVILVKEKA-TGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 T+ +FE+ + +G G F V + +A A+K + K+ + + E ++L Sbjct: 14 TVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL--LGKEIKIL 71 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + +H + AL + + + VMEY NGG+L +L R SED R + +I A+ Sbjct: 72 KELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMR 131 Query: 263 YLHSEKNVVYRDLKLENLMLDKDG---------HIKITDFGLCKEGIKDGATMKTFCGTP 313 LHS K +++RDLK +N++L +KI DFG + ++ T CG+P Sbjct: 132 LLHS-KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFAR-YLQSNMMAATLCGSP 189 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL---FELILMEEIRFPR 370 Y+APEV+ Y D W +G ++Y+ + G+ PF + L +E PR Sbjct: 190 MYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPR 249 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + LL LL+++ K R+ D E H F Sbjct: 250 ETSAPLRQLLLALLQRNHKDRM-----DFDEFFHHPFL 282 >4AT3-A nrPDB Length = 299 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 61/271 (22%), Positives = 109/271 (40%), Gaps = 26/271 (9%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKE-----KATGRYYAMKILKKEVIVAKDEVAHTLT 197 + + + LG+G FGKV L + + A+K LK A+ + Sbjct: 8 QHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD---FHR 64 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV------------- 244 E +L N +H + D L V EY G+L L Sbjct: 65 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE 124 Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 304 ++ + +I + + YL S+ + V+RDL N ++ ++ +KI DFG+ ++ Sbjct: 125 LTQSQMLHIAQQIAAGMVYLASQ-HFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDY 183 Query: 305 TMKTFCGTP--EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 ++ PE + + D W LGVV++E+ G+ P+Y + ++ E I Sbjct: 184 YRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECI 243 Query: 362 LMEE-IRFPRTLGPEAKSLLSGLLKKDPKQR 391 ++ PRT E L+ G +++P R Sbjct: 244 TQGRVLQRPRTCPQEVYELMLGCWQREPHMR 274 >1KOB-A nrPDB Length = 387 Score = 244 bits (624), Expect = 5e-65, Method: Composition-based stats. Identities = 78/279 (27%), Positives = 133/279 (47%), Gaps = 17/279 (6%) Query: 139 AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 + K + ++ L+ LG G FG V EKATGR + K + + K V E Sbjct: 42 VEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK---NE 98 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEI 257 ++ HP L L +F+ + ++E+ +GGELF ++ E SE Y + Sbjct: 99 ISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQA 158 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKD--GHIKITDFGLCKEGIKDGATMKTFCGTPEY 315 L ++H E ++V+ D+K EN+M + +KI DFGL + D +K T E+ Sbjct: 159 CEGLKHMH-EHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPD-EIVKVTTATAEF 216 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----T 371 APE+++ G D W +GV+ Y ++ G PF +D + + + + F + Sbjct: 217 AAPEIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSS 276 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 + PEAK + LL+K+P++RL + ++H + G Sbjct: 277 VSPEAKDFIKNLLQKEPRKRL-----TVHDALEHPWLKG 310 >4AN9-A nrPDB Length = 301 Score = 244 bits (624), Expect = 6e-65, Method: Composition-based stats. Identities = 72/271 (26%), Positives = 122/271 (45%), Gaps = 11/271 (4%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQIIRELQVLHECNS 66 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P++ +F + + ME+ +GG L L + E ++ L YL + Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 126 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +++RD+K N++++ G IK+ DFG+ + I + A F GT Y++PE L+ Y Sbjct: 127 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMA--NEFVGTRSYMSPERLQGTHYS 184 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME-EIRFPR-TLGPEAKSLLSGLLK 385 D W +G+ + EM GR P +L + I+ E + P E + ++ L Sbjct: 185 VQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLI 244 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFAGIVWQHV 416 K+P +R D K++M H F + V Sbjct: 245 KNPAER-----ADLKQLMVHAFIKRSDAEEV 270 >3HKO-A nrPDB Length = 345 Score = 244 bits (622), Expect = 8e-65, Method: Composition-based stats. Identities = 85/316 (26%), Positives = 136/316 (43%), Gaps = 60/316 (18%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVI--VAKDEVAHTLTENRVLQNS 205 ++ +G+G++G V + E T A+KI+ K I + +V TE R+++ Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL-------------------------- 239 HP + L ++ +C VME +GG L L Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 240 --------------SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML--D 283 S + V E +I SAL YLH++ + +RD+K EN + + Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQ-GICHRDIKPENFLFSTN 204 Query: 284 KDGHIKITDFGLCKEGIK----DGATMKTFCGTPEYLAPEVLE--DNDYGRAVDWWGLGV 337 K IK+ DFGL KE K + M T GTP ++APEVL + YG D W GV Sbjct: 205 KSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGV 264 Query: 338 VMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRT----LGPEAKSLLSGLLKKDPKQRLG 393 +++ ++ G +PF + +L +++ F L P A+ LLS LL ++ +R Sbjct: 265 LLHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERF- 323 Query: 394 GGSEDAKEIMQHRFFA 409 DA +QH + + Sbjct: 324 ----DAMRALQHPWIS 335 >3FXW-A nrPDB Length = 336 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 91/288 (31%), Positives = 142/288 (49%), Gaps = 33/288 (11%) Query: 140 KPKHRVTMNEFEYLK-LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 +PK ++++ K +LG G GKV+ + TG+ A+K+L + A+ EV H Sbjct: 20 EPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-YDSPKARQEVDHHW-- 76 Query: 199 NRVLQNSRHPFLTALKYSFQTHDR----LCFVMEYANGGELFFHLSRER--VFSEDRARF 252 Q S P + + ++ L +ME GGELF + F+E A Sbjct: 77 ----QASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAE 132 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTF 309 +I +A+ +LHS N+ +RD+K ENL+ KD +K+TDFG KE ++ ++T Sbjct: 133 IMRDIGTAIQFLHSH-NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQN--ALQTP 189 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL----FELILMEE 365 C TP Y+APEVL Y ++ D W LGV+MY ++CG PFY+ + + I + + Sbjct: 190 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQ 249 Query: 366 IRFPRT----LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 FP + +AK L+ LLK DP +RL + M H + Sbjct: 250 YGFPNPEWSEVSEDAKQLIRLLLKTDPTERL-----TITQFMNHPWIN 292 >2PSQ-A nrPDB Length = 370 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 131/317 (41%), Gaps = 37/317 (11%) Query: 116 EEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR- 174 + +G E E+ PK ++ K LG+G FG+V++ + + Sbjct: 50 TTRLSSTADTPMLAGVSEYELP-EDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 108 Query: 175 ------YYAMKILKKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVM 227 A+K+LK + + +++ ++E +++ +H + L + L ++ Sbjct: 109 KPKEAVTVAVKMLKDDA--TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 166 Query: 228 EYANGGELFFHLSRERV----------------FSEDRARFYGAEIVSALDYLHSEKNVV 271 EYA+ G L +L R + ++ ++YL S+K + Sbjct: 167 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK-CI 225 Query: 272 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRA 329 +RDL N+++ ++ +KI DFGL ++ KT G +++APE L D Y Sbjct: 226 HRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQ 285 Query: 330 VDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKD 387 D W GV+M+E+ G P+ E+LF+L+ + P E ++ Sbjct: 286 SDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV 345 Query: 388 PKQRLGGGSEDAKEIMQ 404 P QR K++++ Sbjct: 346 PSQR-----PTFKQLVE 357 >4AU8-A nrPDB Length = 296 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 125/294 (42%), Gaps = 38/294 (12%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 ++E L+ +G+GT+G V K + T A+K ++ + + + L E +L+ +H Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD-DDDEGVPSSALREICLLKELKHK 65 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 + L + +L V E+ + + S + + + +++ L + HS + Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS-R 124 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND-YG 327 NV++RDLK +NL+++++G +K+ DFGL + T Y P+VL Y Sbjct: 125 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 184 Query: 328 RAVDWWGLGVVMYEMM-CGRLPFYNQDHEKLFELILM-----EEIRFP------------ 369 ++D W G + E+ GR F D + + I E ++P Sbjct: 185 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 244 Query: 370 ------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 L + LL LLK +P QR+ A+E +QH +F+ Sbjct: 245 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYFSDF 293 >3VN9-A nrPDB Length = 340 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 132/312 (42%), Gaps = 19/312 (6%) Query: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168 GLK +E ++ S + +S+ V ++ E + LG+G +G V ++ Sbjct: 12 GLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMR 71 Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRV-LQNSRHPFLTALKYSFQTHDRLCFVM 227 +G+ A+K ++ V E L + + ++ PF + + M Sbjct: 72 HVPSGQIMAVKRIR--ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICM 129 Query: 228 EYANGGELFFH---LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 E + F+ + + + ED IV AL++LHS+ +V++RD+K N++++ Sbjct: 130 ELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA 189 Query: 285 DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL----EDNDYGRAVDWWGLGVVMY 340 G +K+ DFG+ + D G Y+APE + Y D W LG+ M Sbjct: 190 LGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMI 248 Query: 341 EMMCGRLPF--YNQDHEKLFELILMEEIRFP-RTLGPEAKSLLSGLLKKDPKQRLGGGSE 397 E+ R P+ + ++L +++ + P E S LKK+ K+R Sbjct: 249 ELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKER-----P 303 Query: 398 DAKEIMQHRFFA 409 E+MQH FF Sbjct: 304 TYPELMQHPFFT 315 >4EWQ-A nrPDB Length = 383 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 81/358 (22%), Positives = 146/358 (40%), Gaps = 55/358 (15%) Query: 114 EEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATG 173 E + F+S + + E++ + ++ L +G G +G V + TG Sbjct: 14 GTENLYFQSNASQERPTFYRQELNKTIWE---VPERYQNLSPVGSGAYGSVCAAFDTKTG 70 Query: 174 RYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSF------QTHDRLCFVM 227 A+K L + + T E R+L++ +H + L F + + + V Sbjct: 71 LRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVT 129 Query: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287 G +L + + + ++D +F +I+ L Y+HS ++++RDLK NL +++D Sbjct: 130 HLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVNEDCE 186 Query: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGR 346 +KI DFGL + + M + T Y APE+ L Y + VD W +G +M E++ GR Sbjct: 187 LKILDFGLARHTDDE---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 243 Query: 347 LPFYNQDHEKLFELIL----------------------------MEEIRFPRTL---GPE 375 F DH +LIL M ++ F P Sbjct: 244 TLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 303 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSET 433 A LL +L D +R+ A + + H +FA + ++ ++ P+ S Sbjct: 304 AVDLLEKMLVLDSDKRI-----TAAQALAHAYFAQ--YHDPDDEPVADPYDQSFESRD 354 >1JNK-A nrPDB Length = 423 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 70/328 (21%), Positives = 124/328 (37%), Gaps = 61/328 (18%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + ++ LK +G G G V + R A+K L + + E +++ Sbjct: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKC 117 Query: 205 SRHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 H + +L F L VME + L + E +R + +++ Sbjct: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQML 174 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 + +LHS +++RDLK N+++ D +KI DFGL + M + T Y AP Sbjct: 175 CGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAP 232 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME-------------- 364 EV+ Y VD W +G +M EM+ ++ F +D+ + ++ + Sbjct: 233 EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 Query: 365 -------------EIRFPRTLGP---------------EAKSLLSGLLKKDPKQRLGGGS 396 + FP+ +A+ LLS +L DP +R+ Sbjct: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS--- 349 Query: 397 EDAKEIMQHRFFAGIVWQHVYEKKLSPP 424 + +QH + VW E + PP Sbjct: 350 --VDDALQHPYIN--VWYDPAEVEAPPP 373 >3E7O-A nrPDB Length = 360 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 74/328 (22%), Positives = 124/328 (37%), Gaps = 61/328 (18%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + ++ LK +G G G V + G A+K L + + E +L+ Sbjct: 19 TVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSR-PFQNQTHAKRAYRELVLLKC 77 Query: 205 SRHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 H + +L F L VME + L + E +R + +++ Sbjct: 78 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHME--LDHERMSYLLYQML 134 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 + +LHS +++RDLK N+++ D +KI DFGL + M + T Y AP Sbjct: 135 CGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-STNFMMTPYVVTRYYRAP 192 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME-------------- 364 EV+ Y VD W +G +M E++ G + F DH + ++ + Sbjct: 193 EVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQP 252 Query: 365 -----------------EIRFPRTLGP-----------EAKSLLSGLLKKDPKQRLGGGS 396 E FP + P +A+ LLS +L DP +R+ Sbjct: 253 TVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS--- 309 Query: 397 EDAKEIMQHRFFAGIVWQHVYEKKLSPP 424 E ++H + VW E + PP Sbjct: 310 --VDEALRHPYIT--VWYDPAEAEAPPP 333 >4K33-A nrPDB Length = 325 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 129/308 (41%), Gaps = 37/308 (12%) Query: 125 PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR-------YYA 177 P + E+E+ A PK ++ K LG+G FG+V++ + + A Sbjct: 14 PPTLANVSELELP-ADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVA 72 Query: 178 MKILKKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELF 236 +K+LK + +++ ++E +++ +H + L + L ++EYA G L Sbjct: 73 VKMLKDDA--TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLR 130 Query: 237 FHLSRERV----------------FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENL 280 L R + ++ ++YL S+K ++RDL N+ Sbjct: 131 EFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQK-CIHRDLAARNV 189 Query: 281 MLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVV 338 ++ +D +KI DFGL ++ +T G +++APE L D Y D W GV+ Sbjct: 190 LVTEDNVMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 249 Query: 339 MYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGS 396 ++E+ G P+ E+LF+L+ + P + ++ P QR Sbjct: 250 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQR----- 304 Query: 397 EDAKEIMQ 404 K++++ Sbjct: 305 PTFKQLVE 312 >2HW6-A nrPDB Length = 307 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 86/292 (29%), Positives = 135/292 (46%), Gaps = 44/292 (15%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTA 212 +LLG+G + KV G+ YA+KI++K+ ++ E L + + + Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRS---RVFREVETLYQCQGNKNILE 75 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272 L F+ R V E GG + H+ +++ F+E A ++ +ALD+LH+ K + + Sbjct: 76 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHT-KGIAH 134 Query: 273 RDLKLENLMLDKDGH---IKITDFGLCKEGIKDGA-------TMKTFCGTPEYLAPEVL- 321 RDLK EN++ + +KI DF L + + + T CG+ EY+APEV+ Sbjct: 135 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 194 Query: 322 ----EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---------------DHEKLFELIL 362 + Y + D W LGVV+Y M+ G PF KLFE I Sbjct: 195 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 254 Query: 363 MEEIRFPR----TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 + FP + EAK L+S LL +D KQRL A +++QH + G Sbjct: 255 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLS-----AAQVLQHPWVQG 301 >2XNP-A nrPDB Length = 279 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 121/272 (44%), Gaps = 17/272 (6%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++E L +G G++G+ ++ K+ G+ K L + + E ++E +L+ +H Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSM-TEAEKQMLVSEVNLLRELKH 64 Query: 208 PFLTALKYSF--QTHDRLCFVMEYANGGELFFHLSR----ERVFSEDRARFYGAEIVSAL 261 P + +T+ L VMEY GG+L +++ + E+ ++ AL Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 262 DYLHSE----KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 H V++RDLK N+ LD ++K+ DFGL + D + KTF GTP Y++ Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMS 184 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI-RFPRTLGPEA 376 PE + Y D W LG ++YE+ PF ++L I + R P E Sbjct: 185 PEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDEL 244 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 +++ +L R +EI+++ Sbjct: 245 NEIITRMLNLKDYHR-----PSVEEILENPLI 271 >4XLV-A nrPDB Length = 328 Score = 241 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 127/333 (38%), Gaps = 28/333 (8%) Query: 111 KKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP-KHRVTMNEFEYLKLLGKGTFGKVIL--V 167 + F S +P S ++ S+ P + V+ + L+ LG+G+FG V Sbjct: 1 QPDGPLGPLFASSNPEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNA 60 Query: 168 KEKATGR---YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLC 224 ++ G A+K + + + E L E V++ + L Sbjct: 61 RDIIKGEAETRVAVKTVNESASL--RERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTL 118 Query: 225 FVMEYANGGELFFHLSR----------ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 VME G+L +L + AEI + YL+++K V+RD Sbjct: 119 VVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKK-FVHRD 177 Query: 275 LKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDW 332 L N M+ D +KI DFG+ ++ + K G ++APE L+D + + D Sbjct: 178 LAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDM 237 Query: 333 WGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEI-RFPRTLGPEAKSLLSGLLKKDPKQ 390 W GVV++E+ P+ +E++ + ++ P L+ + +P Sbjct: 238 WSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNM 297 Query: 391 RLGGGSEDAKEIMQ---HRFFAGIVWQHVYEKK 420 R +++ H F + + H E K Sbjct: 298 RPTFLE--IVNLLKDDLHPSFPEVSFFHSEENK 328 >5KMM-A nrPDB Length = 329 Score = 241 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 116/310 (37%), Gaps = 35/310 (11%) Query: 122 SGSPSDNSGAEEMEVSLAKPK-------HRVTMNEFEYLKLLGKGTFGKVILVKEK---- 170 S SP++ G+ + P+ H + + LG+G FGKV L + Sbjct: 2 SLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP 61 Query: 171 -ATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEY 229 A+K LK+ A+ E +L +H + L V EY Sbjct: 62 EQDKMLVAVKALKEASESAR---QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEY 118 Query: 230 ANGGELFFHLSRE---------------RVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 G+L L + +++ + + YL + + V+RD Sbjct: 119 MRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYL-AGLHFVHRD 177 Query: 275 LKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP--EYLAPEVLEDNDYGRAVDW 332 L N ++ + +KI DFG+ ++ ++ PE + + D Sbjct: 178 LATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDV 237 Query: 333 WGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQ 390 W GVV++E+ G+ P+Y + + + I E+ PR PE +++ G +++P+Q Sbjct: 238 WSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQ 297 Query: 391 RLGGGSEDAK 400 R A+ Sbjct: 298 RHSIKDVHAR 307 >2XS0-A nrPDB Length = 386 Score = 241 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 123/332 (37%), Gaps = 61/332 (18%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + ++ LK +G G G V + R A+K L + + E +++ Sbjct: 23 TVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR-PFQNQTHAKRAYRELVLMKC 81 Query: 205 SRHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 H + L F L VME + L + E +R + +++ Sbjct: 82 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQME--LDHERMSYLLYQML 138 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 + +LHS +++RDLK N+++ D +KI DFGL + M F T Y AP Sbjct: 139 CGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMVPFVVTRYYRAP 196 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME-------------- 364 EV+ Y VD W +G +M EM+ G + F DH + ++ + Sbjct: 197 EVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP 256 Query: 365 -----------------EIRFPRTLGP-----------EAKSLLSGLLKKDPKQRLGGGS 396 E FP L P +A+ LLS +L D +R+ Sbjct: 257 TVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS--- 313 Query: 397 EDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428 E +QH + VW E + PP P Sbjct: 314 --VDEALQHPYIN--VWYDPSEAEAPPPKIPD 341 >3OHT-A nrPDB Length = 389 Score = 241 bits (614), Expect = 8e-64, Method: Composition-based stats. Identities = 81/385 (21%), Positives = 144/385 (37%), Gaps = 74/385 (19%) Query: 107 ADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVIL 166 + L K+ + S + E++ + ++ L +G G +G V Sbjct: 13 STSLYKKAGSAAAPFTMSHKERPTFYRQELNKTIWE---VPERYQTLSPVGSGAYGSVCS 69 Query: 167 VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL--- 223 + +G A+K L + + T E R+L++ +H + L F L Sbjct: 70 SYDVKSGLKIAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEF 128 Query: 224 ---CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENL 280 V G +L + + + ++D +F +I+ L Y+HS ++++RDLK NL Sbjct: 129 NDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNL 185 Query: 281 MLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVM 339 +++D +KI DFGL + + M + T Y APE+ L Y VD W +G +M Sbjct: 186 AVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIM 242 Query: 340 YEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL--------------------------- 372 E++ GR F DH + I+ P ++ Sbjct: 243 AELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADV 302 Query: 373 ----GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428 P A LL +L D +R+ A E + H +F+ Q Sbjct: 303 FIGANPLAVDLLEKMLVLDTDKRI-----TASEALAHPYFS------------------Q 339 Query: 429 VTSETD---TRYFDEEFTAQMITIT 450 D + +D+ F ++ + I Sbjct: 340 YHDPDDEPESEPYDQSFESRQLEIE 364 >2Y6O-A nrPDB Length = 291 Score = 241 bits (614), Expect = 8e-64, Method: Composition-based stats. Identities = 60/260 (23%), Positives = 109/260 (41%), Gaps = 14/260 (5%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY---YAMKILKKEVIVAKDEVAHTLTE 198 + + + K++G G FG+V + K G+ A+K LK + L+E Sbjct: 8 AKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLK--AGYTDKQRRDFLSE 65 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEI 257 ++ HP + L+ + + EY G L L + F+ + I Sbjct: 66 ASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGI 125 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPE 314 S + YL S+ + V+RDL N++++ + K++DFG+ + D T G Sbjct: 126 GSGMKYL-SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIR 184 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRT-- 371 + APE + + A D W G+VM+E+M G P+++ ++ + + I E R P Sbjct: 185 WTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAI-EEGYRLPPPMD 243 Query: 372 LGPEAKSLLSGLLKKDPKQR 391 L+ +K+ R Sbjct: 244 CPIALHQLMLDCWQKERSDR 263 >4P5Q-A nrPDB Length = 361 Score = 241 bits (614), Expect = 8e-64, Method: Composition-based stats. Identities = 58/259 (22%), Positives = 104/259 (40%), Gaps = 12/259 (4%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY---YAMKILKKEVIVAKDEVAHTLTE 198 + K++G G FG+V + K + A+K LK V + + L E Sbjct: 27 AKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLK--VGYTEKQRRDFLGE 84 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEI 257 ++ HP + L+ + V EY G L L + F+ + I Sbjct: 85 ASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGI 144 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPE 314 S + YL S+ V+RDL N++++ + K++DFGL + D T G Sbjct: 145 ASGMKYL-SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIR 203 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTL 372 + +PE + + A D W G+V++E+M G P++ ++ + + + + P Sbjct: 204 WTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDC 263 Query: 373 GPEAKSLLSGLLKKDPKQR 391 L+ +KD R Sbjct: 264 PAALYQLMLDCWQKDRNNR 282 >4XCU-A nrPDB Length = 300 Score = 240 bits (613), Expect = 8e-64, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 113/284 (39%), Gaps = 27/284 (9%) Query: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVK-------EKATGRYYAMKILKKEVIVAKDEV 192 P + K LG+G FG+V+ + A+K+LK + ++ Sbjct: 9 DPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA--SDKDL 66 Query: 193 AHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV------- 244 A ++E V++ RH + L L ++E A G L L R Sbjct: 67 ADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGP 126 Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 304 S ++ + YL S K ++RDL N+++ +D +KI DFGL + Sbjct: 127 LSFPVLVSCAYQVARGMQYLESRK-CIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 185 Query: 305 TMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELI 361 KT G +++APE L D Y D W G++++E+ G P+ E+LF L+ Sbjct: 186 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 245 Query: 362 LME-EIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 + P PE L+ P QR K++++ Sbjct: 246 REGHRMDRPPHCPPELYGLMRECWHAAPSQR-----PTFKQLVE 284 >4QNY-A nrPDB Length = 354 Score = 240 bits (613), Expect = 8e-64, Method: Composition-based stats. Identities = 78/315 (24%), Positives = 134/315 (42%), Gaps = 47/315 (14%) Query: 137 SLAKPKHRVTM--NEFEYLKLLGKGTFGKVILVKE-KATGRYYAMKILKKEVIVAKDEVA 193 SLA+ + V + + +++G G++G VI ++ K+ R AMK + KE+ Sbjct: 7 SLAELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAK 66 Query: 194 HTLTENRVLQNSRHPFLTALKYSFQTHD-----RLCFVMEYANGGELFFHLSRERVFSED 248 L E ++L + + L+ D VM+ +L L + +E Sbjct: 67 RILREIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLRSGQELTEA 125 Query: 249 RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT 308 +F+ + + AL +HS V++RD+ N++++ + +KI DFGL KE G M Sbjct: 126 HIQFFIYQALRALHIIHS-AGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTD 184 Query: 309 FCGTPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI------ 361 + Y APE V+ED DY +D WG+G ++ E++ R F +D + I Sbjct: 185 YVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGT 244 Query: 362 -----------------LMEEIRFP--------RTLGPEAKSLLSGLLKKDPKQRLGGGS 396 L ++ P T PEA LL +L +PK+R+ Sbjct: 245 PSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRI---- 300 Query: 397 EDAKEIMQHRFFAGI 411 + M+H F + Sbjct: 301 -TVLQAMRHPFLEQL 314 >3ZDU-A nrPDB Length = 325 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 128/296 (43%), Gaps = 40/296 (13%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +M +E L +G+G++G V+ K K TG+ A+KI + + +++A + E + L+ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIA--MREIKFLKQF 58 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 H L L F+ ++ V E+ + L R R Y +I+ A+DYLH Sbjct: 59 HHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLH 118 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE-VLEDN 324 S N+++RD+K EN+++ + G K+ DFG + G T Y APE VL+D Sbjct: 119 SN-NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDT 177 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME-------------------E 365 YG+ VD W LG ++ EM G + L I+++ Sbjct: 178 SYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAG 237 Query: 366 IRFPRTLGPE------------AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + P+ P+ ++ L+ DP R+ +++ H +F Sbjct: 238 VVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSS-----DLLHHEYFT 288 >5FM2-A nrPDB Length = 355 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 80/348 (22%), Positives = 142/348 (40%), Gaps = 46/348 (13%) Query: 99 WTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA--------KPKHRVTMNEF 150 I + ++ + S S + + ME ++ PK Sbjct: 7 HKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNL 66 Query: 151 EYLKLLGKGTFGKVILV-----KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 K LG+G FGKV+ K +A A+K+LK+ + E+ L+E VL+ Sbjct: 67 VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLSEFNVLKQV 124 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR------------------------ 241 HP + L + L ++EYA G L L Sbjct: 125 NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPD 184 Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 ER + + +I + YL +E +V+RDL N+++ + +KI+DFGL ++ + Sbjct: 185 ERALTMGDLISFAWQISQGMQYL-AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE 243 Query: 302 DGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLF 358 + + +K G +++A E L D+ Y D W GV+++E++ G P+ E+LF Sbjct: 244 EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF 303 Query: 359 ELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQR--LGGGSEDAKEIM 403 L+ + P E L+ K++P +R S+D +++M Sbjct: 304 NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 351 >6CCF-A nrPDB Length = 290 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 81/295 (27%), Positives = 141/295 (47%), Gaps = 37/295 (12%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKD-------------- 190 + +N+++ +GKG +G V L ++ R+YAMK+L K+ ++ + Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 191 ---------EVAHTLTENRVLQNSRHPFLTALKYSFQT--HDRLCFVMEYANGGELFFHL 239 + E +L+ H + L D L V + G + + Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-V 120 Query: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299 ++ FSE++AR Y +++ L+YLH +K +V+RD+K NL+L DGH+KI DFG+ + Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQK-IVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 300 IKDGATMKTFCGTPEYLAPEVLEDNDY---GRAVDWWGLGVVMYEMMCGRLPFYNQDHEK 356 + A + + GTP ++APE + D+ G+A+D W GV +Y + G+ PF + Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 239 Query: 357 LFELILMEEIRFP--RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 L I E + FP + E K L+ +L K+P+ R+G +I H + Sbjct: 240 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIG-----VPDIKLHPWVT 289 >2H8H-A nrPDB Length = 535 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 111/267 (41%), Gaps = 12/267 (4%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 LAK + LG+G FG+V + T R A+K LK + L Sbjct: 257 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP----EAFLQ 311 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGA 255 E +V++ RH L L + + + V EY + G L L E + + A Sbjct: 312 EAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 370 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-E 314 +I S + Y+ N V+RDL+ N+++ ++ K+ DFGL + + T + P + Sbjct: 371 QIASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 429 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTL 372 + APE + D W G+++ E+ GR+P+ + ++ + + + P Sbjct: 430 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 489 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSEDA 399 L+ +K+P++R A Sbjct: 490 PESLHDLMCQCWRKEPEERPTFEYLQA 516 >4UYA-A nrPDB Length = 340 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 69/268 (25%), Positives = 119/268 (44%), Gaps = 19/268 (7%) Query: 139 AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH-TLT 197 P H V E +L+G G FG+V + G+ A+K +++ A Sbjct: 18 GSPVH-VAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRR 74 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257 E R+ RHP + L+ LC V+E+A GG L L+ R + +I Sbjct: 75 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAGRR-IPPHVLVNWAVQI 133 Query: 258 VSALDYLHSEK--NVVYRDLKLENLMLDK--------DGHIKITDFGLCKEGIKDGATMK 307 + YLH E +++RDLK N++L + + +KITDFGL +E + T Sbjct: 134 ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHR--TTKM 191 Query: 308 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIR 367 G ++APEV++ + + + D W GV+++E++ G +P+ D + + + ++ Sbjct: 192 ATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT 251 Query: 368 --FPRTLGPEAKSLLSGLLKKDPKQRLG 393 P T L+ ++DP R Sbjct: 252 LPIPSTCPEPFAKLMKECWQQDPHIRPS 279 >4BGQ-A nrPDB Length = 304 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 128/307 (41%), Gaps = 40/307 (13%) Query: 137 SLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 196 S+ P MN+FE L ++G+G +G V+ + K T A+K K + ++ TL Sbjct: 1 SMKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK-DSEENEEVKETTL 59 Query: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 E ++L+ + + LK +F+ +L V EY L ++ + Y + Sbjct: 60 RELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQ 119 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK-DGATMKTFCGTPEY 315 ++ A+ + H + ++V+RD+K ENL++ + +K+ DFG + + + A T Y Sbjct: 120 LIKAIHWCH-KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWY 178 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM------------ 363 +PE+L YG++VD W +G ++ E+ G+ F + I Sbjct: 179 RSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKL 238 Query: 364 -------EEIRFPRTLGPE-------------AKSLLSGLLKKDPKQRLGGGSEDAKEIM 403 +RFP P+ L+ LLK DP R ++ + Sbjct: 239 FYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLT-----EQCL 293 Query: 404 QHRFFAG 410 H F Sbjct: 294 NHPTFQT 300 >5X5O-A nrPDB Length = 310 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 61/256 (23%), Positives = 109/256 (42%), Gaps = 19/256 (7%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 ++ ++ ++ + G G+FG V K + + A+K L K E +L Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-----------IEKEAEILS 59 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEIVSAL 261 H + V EYA+ G L+ +++ R D + ++ + Sbjct: 60 VLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGM 119 Query: 262 DYLHSEKNV--VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 YLH E V ++RDLK N+++ DG +KI DFG + + T + GT ++APE Sbjct: 120 HYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR--FHNHTTHMSLVGTFPWMAPE 177 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI--LMEEIRFPRTLGPEAK 377 V++ D + GVV++EM+ +PF + ++ L+ E + P + Sbjct: 178 VIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFA 237 Query: 378 SLLSGLLKKDPKQRLG 393 LL + D K+R Sbjct: 238 ELLHQCWEADAKKRPS 253 >4GS6-A nrPDB Length = 315 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 83/309 (26%), Positives = 135/309 (43%), Gaps = 27/309 (8%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 H + E E +++G+G FG V K +A + A+K ++ ++ E + E R L Sbjct: 4 HMIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIE-----SESERKAFIVELRQL 56 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF---SEDRARFYGAEIVS 259 HP + L + + +C VMEYA GG L+ L + A + + Sbjct: 57 SRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 260 ALDYLHSE--KNVVYRDLKLENLMLDKDGHI-KITDFGLCKEGIKDGATMKTFCGTPEYL 316 + YLHS K +++RDLK NL+L G + KI DFG M G+ ++ Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA---CDIQTHMTNNKGSAAWM 171 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY--NQDHEKLFELILME-EIRFPRTLG 373 APEV E ++Y D + G++++E++ R PF ++ + + L Sbjct: 172 APEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLP 231 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH--RFFAGIV--WQHVYEKKLSPPFKPQV 429 +SL++ KDP QR E+ +IM H R+F G Q+ + L P +V Sbjct: 232 KPIESLMTRCWSKDPSQRPS--MEEIVKIMTHLMRYFPGADEPLQYPCQHSLPPGEDGRV 289 Query: 430 TSETDTRYF 438 D F Sbjct: 290 EPYVDFAEF 298 >6GQK-A nrPDB Length = 328 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 115/308 (37%), Gaps = 35/308 (11%) Query: 124 SPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILV-----KEKATGRYYAM 178 S +N + K N + K LG G FGKV+ + A+ Sbjct: 17 SNGNNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAV 76 Query: 179 KILKKEVIVAKDEVAHTLTENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237 K+LK + E ++E +VL H + L + + EY G+L Sbjct: 77 KMLKPSAHSTEREA--LMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLN 134 Query: 238 HLSRER----------------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLM 281 L R+R + + + ++ + +L S KN ++RDL N++ Sbjct: 135 FLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLAS-KNCIHRDLAARNIL 193 Query: 282 LDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVM 339 L KI DFGL ++ D + +++APE + ++ Y D W G+ + Sbjct: 194 LTHGNITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFL 253 Query: 340 YEMMC-GRLPFYNQDHEKLFELILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQRLGGGS 396 +E+ G P+ + F ++ E R P E ++ DP +R Sbjct: 254 WELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKR----- 308 Query: 397 EDAKEIMQ 404 K+I+Q Sbjct: 309 PTFKQIVQ 316 >5H2U-A nrPDB Length = 267 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 106/250 (42%), Gaps = 9/250 (3%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 EF + LG G FG+V K A+K++ ++ ++ + + +E + ++ Sbjct: 4 PREEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLLHQQMLQ---SEIQAMKKL 59 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDY 263 RH + AL D + + E G L L E+V ++ + Y Sbjct: 60 RHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCY 119 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323 L S+ N ++RDL N+++ ++ K+ DFGL + +D ++ APE L Sbjct: 120 LESQ-NYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSR 178 Query: 324 NDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLS 381 Y D W G++++EM G++P+ + + F + + P P L+ Sbjct: 179 GHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLML 238 Query: 382 GLLKKDPKQR 391 +DP+QR Sbjct: 239 TCWCRDPEQR 248 >6DTL-A nrPDB Length = 364 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 126/295 (42%), Gaps = 45/295 (15%) Query: 153 LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 + +GKG +G V T A+K + K + TL E ++L++ H + A Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLREIKLLRHMDHENIVA 93 Query: 213 LKYSFQTH-----DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 ++ + + E + +L + + SE+ +++ +I+ L Y+HS Sbjct: 94 IRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS- 151 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND-Y 326 NV++RDLK NL+L+ + +KI DFGL + + M + T Y APE+L ++ Y Sbjct: 152 ANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDY 210 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM----------------------E 364 A+D W +G + E+M + F +DH L++ + Sbjct: 211 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 270 Query: 365 EIRFPR--------TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 +PR T+ P A L+ +L DP++R+ + + H + + Sbjct: 271 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHPYLNSL 320 >3DKO-A nrPDB Length = 318 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 126/294 (42%), Gaps = 17/294 (5%) Query: 112 KQEEEEMDFRSGSPS-----DNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVIL 166 ++ +EE+ F P D E+ ++ + + + + +++G G FG+V Sbjct: 2 QEGDEELYFHFKFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCS 61 Query: 167 VKEKATGRY---YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 223 + K G+ A+K LK V + + L E ++ HP + L+ + Sbjct: 62 GRLKLPGKRDVAVAIKTLK--VGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPV 119 Query: 224 CFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282 V+E+ G L L + F+ + I + + YL ++ V+RDL N+++ Sbjct: 120 MIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL-ADMGYVHRDLAARNILV 178 Query: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVLEDNDYGRAVDWWGLGVVM 339 + + K++DFGL + D + T G + APE ++ + A D W G+VM Sbjct: 179 NSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVM 238 Query: 340 YEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQR 391 +E+M G P+++ ++ + + I + P L+ +K+ +R Sbjct: 239 WEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAER 292 >6QAU-A nrPDB Length = 280 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 80/279 (28%), Positives = 128/279 (45%), Gaps = 24/279 (8%) Query: 146 TMNEFEYLK--LLGKGTFGKVILVKEKA-TGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + +FEY K L+G G F V + + T A+K + K+ + + E ++L Sbjct: 7 VVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKIL 64 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + +H + AL + + + VMEY NGG+L +L + SED R + +I +A+ Sbjct: 65 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR 124 Query: 263 YLHSEKNVVYRDLKLENLMLD---------KDGHIKITDFGLCKEGIKDGATMKTFCGTP 313 LHS K +++RDLK +N++L IKI DFG + + CG+P Sbjct: 125 ILHS-KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFAR-YLHSNMMAADLCGSP 182 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE---IRFPR 370 Y+APEV+ Y D W +G V+Y+ + G+ PF + L PR Sbjct: 183 MYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPR 242 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 P +LL GLL+++ K R+ D + H F Sbjct: 243 ETSPYLANLLLGLLQRNQKDRM-----DFEAFFSHPFLE 276 >6F3F-A nrPDB Length = 455 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 63/267 (23%), Positives = 111/267 (41%), Gaps = 12/267 (4%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 LAK + LG+G FG+V + T R A+K LK + L Sbjct: 177 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP----EAFLQ 231 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGA 255 E +V++ RH L L + + + V EY N G L L E + + A Sbjct: 232 EAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSA 290 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-E 314 +I S + Y+ N V+RDL+ N+++ ++ K+ DFGL + + T + P + Sbjct: 291 QIASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 349 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTL 372 + APE + D W G+++ E+ GR+P+ + ++ + + + P Sbjct: 350 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 409 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSEDA 399 L+ +K+P++R A Sbjct: 410 PESLHDLMCQCWRKEPEERPTFEYLQA 436 >4H1J-A nrPDB Length = 293 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 60/263 (22%), Positives = 115/263 (43%), Gaps = 11/263 (4%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK---EKATGRYYAMKILKKEVIVAKDEV 192 V P++ + + ++LG+G FG+V K A+K KK+ + E Sbjct: 12 VPRGSPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKE- 70 Query: 193 AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRAR 251 ++E +++N HP + L + +ME GEL +L R + Sbjct: 71 -KFMSEAVIMKNLDHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTLV 128 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG 311 Y +I A+ YL S N V+RD+ + N+++ +K+ DFGL + + + Sbjct: 129 LYSLQICKAMAYLES-INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTR 187 Query: 312 TP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRF 368 P ++++PE + + A D W V M+E++ G+ PF+ +++ + ++ + Sbjct: 188 LPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPK 247 Query: 369 PRTLGPEAKSLLSGLLKKDPKQR 391 P P +L++ DP R Sbjct: 248 PDLCPPVLYTLMTRCWDYDPSDR 270 >4E93-A nrPDB Length = 377 Score = 237 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 60/262 (22%), Positives = 105/262 (40%), Gaps = 10/262 (3%) Query: 139 AKPKHRVTMN--EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 196 A PK + +N + + +G+G FG+V + +A A+K ++ + D A L Sbjct: 103 AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRET--LPPDLKAKFL 160 Query: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGA 255 E R+L+ HP + L + VME GG+ L E Sbjct: 161 QEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVG 220 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT--FCGTP 313 + + ++YL S K ++RDL N ++ + +KI+DFG+ +E Sbjct: 221 DAAAGMEYLES-KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPV 279 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRT 371 ++ APE L Y D W G++++E G P+ N +++ E + + P Sbjct: 280 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPEL 339 Query: 372 LGPEAKSLLSGLLKKDPKQRLG 393 L+ +P QR Sbjct: 340 CPDAVFRLMEQCWAYEPGQRPS 361 >5VO2-A nrPDB Length = 300 Score = 237 bits (606), Expect = 6e-63, Method: Composition-based stats. Identities = 68/265 (25%), Positives = 119/265 (44%), Gaps = 21/265 (7%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 V E L+ +G G G V L + G A+K ++ + + ++ H L Sbjct: 7 WEVPFEEILDLQWVGSGAQGAVFLGR--FHGEEVAVKKVR---DLKETDIKH-------L 54 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + +HP + K C +ME+ G+L+ L R + + I ++ Sbjct: 55 RKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMN 114 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 YLH K +++RDLK N+++ D +KI+DFG KE + D +T +F GT ++APEV+ Sbjct: 115 YLHLHK-IIHRDLKSPNMLITYDDVVKISDFGTSKE-LSDKSTKMSFAGTVAWMAPEVIR 172 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRF--PRTLGPEAKSLL 380 + VD W GVV++E++ G +P+ + D + + + P + K LL Sbjct: 173 NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILL 232 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQH 405 P+ R ++I+ H Sbjct: 233 RQCWNSKPRNR-----PSFRQILLH 252 >4IC8-A nrPDB Length = 442 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 78/340 (22%), Positives = 151/340 (44%), Gaps = 60/340 (17%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +E+E ++ +G G +G V + + TG+ A+K + V + TL E ++L++ +H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN-AKRTLRELKILKHFKH 113 Query: 208 PFLTALKYSFQTH------DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 + A+K + + V++ +L + + + + R++ +++ L Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 172 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI----KDGATMKTFCGTPEYLA 317 Y+HS + V++RDLK NL+++++ +KI DFG+ + + M + T Y A Sbjct: 173 KYMHSAQ-VIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 231 Query: 318 PE-VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM------------- 363 PE +L ++Y +A+D W +G + EM+ R F +++ +LI+M Sbjct: 232 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 291 Query: 364 --EEIR-FPRTLGP---------------EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 E +R + ++L P +A SLL +L+ +P R+ A ++H Sbjct: 292 GAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARIS-----AAAALRH 346 Query: 406 RFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQ 445 F A K P +P D FD E + Sbjct: 347 PFLA---------KYHDPDDEPDCAPPFD-FAFDREALTR 376 >3OZ6-A nrPDB Length = 388 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 73/368 (19%), Positives = 133/368 (36%), Gaps = 86/368 (23%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 R + ++E +K LGKG +G V ++ TG A+K + + + T E +L Sbjct: 4 DRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIF-DAFQNSTDAQRTFREIMIL 62 Query: 203 QNSR-HPFLTALKYSFQTHD--RLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 H + L + + + V +Y +L + R + ++ +++ Sbjct: 63 TELSGHENIVNLLNVLRADNDRDVYLVFDYME-TDLHAVI-RANILEPVHKQYVVYQLIK 120 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI------------------- 300 + YLHS +++RD+K N++L+ + H+K+ DFGL + + Sbjct: 121 VIKYLHS-GGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTEN 179 Query: 301 --KDGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357 D + + T Y APE+L Y + +D W LG ++ E++CG+ F Sbjct: 180 FDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQ 239 Query: 358 FELILMEEIRFPRT---------------------------------------------- 371 E I+ I FP Sbjct: 240 LERII-GVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPK 298 Query: 372 --LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF---FAGIVWQHVYEKKLSPPFK 426 EA LL LL+ +P +R+ A + ++H F F + + ++ P Sbjct: 299 ADCNEEALDLLDKLLQFNPNKRIS-----ANDALKHPFVSIFHNPNEEPNCDHIITIPIN 353 Query: 427 PQVTSETD 434 V D Sbjct: 354 DNVKHSID 361 >4ZSG-A nrPDB Length = 347 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 78/340 (22%), Positives = 151/340 (44%), Gaps = 60/340 (17%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +E+E ++ +G G +G V + + TG+ A+K + V + TL E ++L++ +H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN-AKRTLRELKILKHFKH 65 Query: 208 PFLTALKYSFQTH------DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 + A+K + + V++ +L + + + + R++ +++ L Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI----KDGATMKTFCGTPEYLA 317 Y+HS + V++RDLK NL+++++ +KI DFG+ + + M + T Y A Sbjct: 125 KYMHSAQ-VIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 183 Query: 318 PE-VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM------------- 363 PE +L ++Y +A+D W +G + EM+ R F +++ +LI+M Sbjct: 184 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 243 Query: 364 --EEIR-FPRTLGP---------------EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 E +R + ++L P +A SLL +L+ +P R+ A ++H Sbjct: 244 GAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARIS-----AAAALRH 298 Query: 406 RFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQ 445 F A K P +P D FD E + Sbjct: 299 PFLA---------KYHDPDDEPDCAPPFD-FAFDREALTR 328 >2F9G-A nrPDB Length = 353 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 77/329 (23%), Positives = 134/329 (40%), Gaps = 62/329 (18%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++F+ LLG+G +G V K TG A+K + E TL E ++L++ +H Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKH 68 Query: 208 PFLTALK-----YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262 + + SF+ + + + E + ++ S+D +++ + + A+ Sbjct: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK----------EGIKDGATMKTFCGT 312 LH NV++RDLK NL+++ + +K+ DFGL + E + M + T Sbjct: 127 VLHGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 Query: 313 PEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-------- 363 Y APEV L Y RA+D W G ++ E+ R F +D+ LI Sbjct: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Query: 364 EEIR-------------------------FPRTLGPEAKSLLSGLLKKDPKQRLGGGSED 398 ++R FPR + P+ LL +L DP +R+ Sbjct: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-VNPKGIDLLQRMLVFDPAKRI-----T 299 Query: 399 AKEIMQHRFFAGI--VWQHVYEKKLSPPF 425 AKE ++H + + + P F Sbjct: 300 AKEALEHPYLQTYHDPNDEPEGEPIPPSF 328 >2R2P-A nrPDB Length = 295 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 59/260 (22%), Positives = 107/260 (41%), Gaps = 14/260 (5%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY---YAMKILKKEVIVAKDEVAHTLTE 198 + + +++G G FG+V + K G+ A+K LK V + + L E Sbjct: 16 AKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLK--VGYTEKQRRDFLGE 73 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEI 257 ++ HP + L+ + V EY G L L + F+ + I Sbjct: 74 ASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 133 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPE 314 + + YL S+ V+RDL N++++ + K++DFGL + D T G Sbjct: 134 SAGMKYL-SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIR 192 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRT-- 371 + APE + + A D W G+VM+E++ G P++ ++ + + + E R P Sbjct: 193 WTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV-EEGYRLPSPMD 251 Query: 372 LGPEAKSLLSGLLKKDPKQR 391 L+ +K+ R Sbjct: 252 CPAALYQLMLDCWQKERNSR 271 >4EBW-A nrPDB Length = 304 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 106/265 (40%), Gaps = 11/265 (4%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATG---RYYAMKILKKEVIVAKDEVAHTLTEN 199 + + E + +G+G FG V + A+K K + L E Sbjct: 33 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN--CTSDSVREKFLQEA 90 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIV 258 ++ HP + L T + + +ME GEL L R+ Y ++ Sbjct: 91 LTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLS 149 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLA 317 +AL YL S++ V+RD+ N+++ + +K+ DFGL + + P +++A Sbjct: 150 TALAYLESKR-FVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMA 208 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPE 375 PE + + A D W GV M+E++ G PF + + I E + P P Sbjct: 209 PESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPT 268 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAK 400 SL++ DP +R A+ Sbjct: 269 LYSLMTKCWAYDPSRRPRFTELKAQ 293 >1V0B-A nrPDB Length = 288 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 120/296 (40%), Gaps = 38/296 (12%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 M ++ L+ +G+GT+G V + G +A+K ++ E + + T+ E +L+ + Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEK-EDEGIPSTTIREISILKELK 58 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 H + L T RL V E+ + E A+ + ++++ + Y H Sbjct: 59 HSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHD 118 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED-ND 325 + V++RDLK +NL+++++G +KI DFGL + T Y AP+VL Sbjct: 119 RR-VLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM----------------EEIR-- 367 Y +D W +G + EM+ G F I + Sbjct: 178 YSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPN 237 Query: 368 -----------FPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412 F + L LLS +LK DP QR+ AK+ ++H +F Sbjct: 238 FTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRI-----TAKQALEHAYFKENN 288 >6CKI-A nrPDB Length = 316 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 87/300 (29%), Positives = 138/300 (46%), Gaps = 45/300 (15%) Query: 148 NEFEYLK-LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + ++ + +LG+G +V T + YA+KI++K+ + E +L + Sbjct: 12 DVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRS---RVFREVEMLYQCQ 68 Query: 207 -HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 H + L F+ DR V E GG + H+ + R F+E A ++ SALD+LH Sbjct: 69 GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH 128 Query: 266 SEKNVVYRDLKLENLMLDKDGH---IKITDFGLCKEGIKDGA-------TMKTFCGTPEY 315 + K + +RDLK EN++ + +KI DFGL +G + T CG+ EY Sbjct: 129 N-KGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEY 187 Query: 316 LAPEVL-----EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEK-------------- 356 +APEV+ E + Y + D W LGV++Y ++ G PF + Sbjct: 188 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 247 Query: 357 -LFELILMEEIRFPR----TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 LFE I + FP + AK L+S LL +D KQRL A +++QH + G Sbjct: 248 MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLS-----AAQVLQHPWVQGC 302 >1JPA-A nrPDB Length = 312 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 119/279 (42%), Gaps = 18/279 (6%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR---YYAMKILKKEVIVAKDEVAHTLTE 198 + ++ + +++G G FG+V K G+ + A+K LK + + L+E Sbjct: 27 AKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSG--YTEKQRRDFLSE 84 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEI 257 ++ HP + L+ + + E+ G L L + F+ + I Sbjct: 85 ASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGI 144 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD--GATMKTFCG---T 312 + + YL ++ N V+RDL N++++ + K++DFGL + D T + G Sbjct: 145 AAGMKYL-ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIP 203 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRT 371 + APE ++ + A D W G+VM+E+M G P+++ ++ + I ++ R P Sbjct: 204 IRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI-EQDYRLPPP 262 Query: 372 --LGPEAKSLLSGLLKKDPKQR--LGGGSEDAKEIMQHR 406 L+ +KD R G +++++ Sbjct: 263 MDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP 301 >2DQ7-X nrPDB Length = 283 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 57/254 (22%), Positives = 107/254 (42%), Gaps = 12/254 (4%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + + +K LG G FG+V + A+K LK + + L E +++ Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPES----FLEEAQIM 58 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS--RERVFSEDRARFYGAEIVSA 260 + +H L L + + + V EY N G L L R A++ + Sbjct: 59 KKLKHDKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 117 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPE 319 + Y+ N ++RDL+ N+++ KI DFGL + + T + P ++ APE Sbjct: 118 MAYI-ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPE 176 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAK 377 + D W G+++ E++ GR+P+ ++ ++ E + + P+ Sbjct: 177 AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLH 236 Query: 378 SLLSGLLKKDPKQR 391 L+ KKDP++R Sbjct: 237 ELMIHCWKKDPEER 250 >5AWM-A nrPDB Length = 394 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 74/326 (22%), Positives = 122/326 (37%), Gaps = 62/326 (19%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + + L+ +G G G V + T + A+K L + E ++++ H Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNH 102 Query: 208 PFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261 + L +F L VME + L + + DR + +++ + Sbjct: 103 KNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMD--LDHDRMSYLLYQMLCGI 159 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +LHS +++RDLK N+++ D +KI DFGL + M + T Y APEV+ Sbjct: 160 KHLHS-AGIIHRDLKPSNIVVKADCTLKILDFGLARTA-GTTFMMTPYVVTRYYRAPEVI 217 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM------------------ 363 Y VD W +G +M EM+ G + F DH + I+ Sbjct: 218 LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 277 Query: 364 ------EEIR-------FPRTLGP------------EAKSLLSGLLKKDPKQRLGGGSED 398 FP L P +A++LLS +L DP+QR+ Sbjct: 278 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS----- 332 Query: 399 AKEIMQHRFFAGIVWQHVYEKKLSPP 424 E ++H + VW E P Sbjct: 333 VDEALKHEYIN--VWYDAEEVDAPAP 356 >5MJB-A nrPDB Length = 305 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 117/279 (41%), Gaps = 18/279 (6%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR---YYAMKILKKEVIVAKDEVAHTLTE 198 + ++ + +++G G FG+V + K G+ Y A+K LK ++ + L+E Sbjct: 20 AKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLK--AGYSEKQRRDFLSE 77 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEI 257 ++ H + L+ + + E+ L L + F+ + I Sbjct: 78 ASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGI 137 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD--GATMKTFCG---T 312 + + YL SE N V+RDL N++++ + K++DFGL + D T + G Sbjct: 138 AAGMKYL-SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIP 196 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRT 371 + APE + + A D W G+VM+E+M G P+++ ++ + I ++ R P Sbjct: 197 VRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAI-EQDYRLPPP 255 Query: 372 --LGPEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHR 406 L+ +KD R +++++ Sbjct: 256 MDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNP 294 >4MYG-A nrPDB Length = 372 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 86/355 (24%), Positives = 138/355 (38%), Gaps = 74/355 (20%) Query: 128 NSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIV 187 N A E+ + P H +G G +G V +K +G A+K L + Sbjct: 35 NKTAWELPKTYVSPTH------------VGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQ 81 Query: 188 AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSR 241 ++ E +L++ +H + L F L VM + +L + Sbjct: 82 SEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQKIMGM 140 Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 E FSE++ ++ +++ L Y+HS VV+RDLK NL +++D +KI DFGL + Sbjct: 141 E--FSEEKIQYLVYQMLKGLKYIHS-AGVVHRDLKPGNLAVNEDCELKILDFGLARHA-- 195 Query: 302 DGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360 A M + T Y APEV+ Y + VD W +G +M EM+ G+ F +D+ Sbjct: 196 -DAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQ 254 Query: 361 ILM------------------------------EEIR--FPRTLGPEAKSLLSGLLKKDP 388 IL ++ FPR P+A LL +L+ D Sbjct: 255 ILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA-SPQAADLLEKMLELDV 313 Query: 389 KQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 443 +RL A + + H FF P + + D E+ T Sbjct: 314 DKRL-----TAAQALTHPFFEPF---------RDPEEETEAQQPFDDSLEHEKLT 354 >5EG3-A nrPDB Length = 334 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 129/304 (42%), Gaps = 37/304 (12%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR-------YYAMKIL 181 +G E E+ PK ++ K LG+G FG+V++ + + A+K+L Sbjct: 17 AGVSEFELP-EDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML 75 Query: 182 KKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240 K + + +++ ++E +++ +H + L + L ++ YA+ G L +L Sbjct: 76 KDDA--TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLR 133 Query: 241 RERV----------------FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 R + ++ ++YL S+K ++RDL N+++ + Sbjct: 134 ARRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK-CIHRDLAARNVLVTE 192 Query: 285 DGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 + +KI DFGL ++ +T G +++APE L D Y D W GV+M+E+ Sbjct: 193 NNVMKIADFGLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 252 Query: 343 MC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 G P+ E+LF+L+ + P E ++ P QR K Sbjct: 253 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR-----PTFK 307 Query: 401 EIMQ 404 ++++ Sbjct: 308 QLVE 311 >1FVR-A nrPDB Length = 327 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 67/278 (24%), Positives = 122/278 (43%), Gaps = 32/278 (11%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYY--AMKILKKEVIVAKDEVAHTLTENRVL-QN 204 N+ ++ ++G+G FG+V+ + K G A+K +K+ +KD+ E VL + Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKE--YASKDDHRDFAGELEVLCKL 82 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV----------------FSED 248 HP + L + + L +EYA G L L + RV S Sbjct: 83 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 249 RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT 308 + + A++ +DYL S+K ++RDL N+++ ++ KI DFGL + ++ KT Sbjct: 143 QLLHFAADVARGMDYL-SQKQFIHRDLAARNILVGENYVAKIADFGLSRG--QEVYVKKT 199 Query: 309 FCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-E 365 P ++A E L + Y D W GV+++E++ G P+ +L+E + Sbjct: 200 MGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 259 Query: 366 IRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403 + P E L+ ++ P +R +I+ Sbjct: 260 LEKPLNCDDEVYDLMRQCWREKPYER-----PSFAQIL 292 >1NY3-A nrPDB Length = 400 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 89/290 (30%), Positives = 137/290 (47%), Gaps = 32/290 (11%) Query: 137 SLAKPKHRVTMNEFEY-LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 S + K +++++ ++LG G GKV+ + K T +A+K+L ++ A+ EV Sbjct: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-QDCPKARREVELH 108 Query: 196 LTENRVLQNSRHPFLTALKYSFQT----HDRLCFVMEYANGGELFFHLSRER--VFSEDR 249 S+ P + + ++ L VME +GGELF + F+E Sbjct: 109 WR------ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATM 306 A I A+ YLHS N+ +RD+K ENL+ + +K+TDFG KE + + Sbjct: 163 ASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-L 220 Query: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL----FELIL 362 T C TP Y+APEVL Y ++ D W LGV+MY ++CG PFY+ + I Sbjct: 221 TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 280 Query: 363 MEEIRFPRT----LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 M + FP + E K L+ LLK +P QR+ E M H + Sbjct: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWI 325 >4U41-A nrPDB Length = 332 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 79/330 (23%), Positives = 142/330 (43%), Gaps = 46/330 (13%) Query: 123 GSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK 182 GS +D+ +++ L+ + + FE ++++G GT+G+V + TG+ A+K++ Sbjct: 1 GSANDSPAKSLVDIDLSSLRDPAGI--FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD 58 Query: 183 KEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQ------THDRLCFVMEYANGGEL 235 V +DE E +L+ S H + +F D+L VME+ G + Sbjct: 59 ----VTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSI 114 Query: 236 FFHLS--RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF 293 + + ED + EI+ L +LH +V++RD+K +N++L ++ +K+ DF Sbjct: 115 TDLVKNTKGNTLKEDWIAYISREILRGLAHLHIH-HVIHRDIKGQNVLLTENAEVKLVDF 173 Query: 294 GLCKEGIKDGATMKTFCGTPEYLAPEVLE-----DNDYGRAVDWWGLGVVMYEMMCGRLP 348 G+ + + TF GTP ++APEV+ D Y D W G+ EM G P Sbjct: 174 GVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPP 233 Query: 349 FYNQDHEKLFELILMEEIRFPRTLGPEA---------KSLLSGLLKKDPKQRLGGGSEDA 399 + + LI PR P S + G L K+ QR Sbjct: 234 LCDMHPMRALFLI-------PRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQR-----PST 281 Query: 400 KEIMQHRFFAGIVWQHVYEKKLSPPFKPQV 429 +++++H F E+++ K + Sbjct: 282 EQLLKHPFIR----DQPNERQVRIQLKDHI 307 >5SYS-A nrPDB Length = 286 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 110/267 (41%), Gaps = 12/267 (4%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 LAK + LG+G FG+ + T R A+K LK + L Sbjct: 8 LAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSP----EAFLQ 62 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGA 255 E +V++ RH L L + + + V EY + G L L E + + A Sbjct: 63 EAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAA 121 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-E 314 +I S + Y+ N V+RDL+ N+++ ++ K+ DFGL + + T + P + Sbjct: 122 QIASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 180 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTL 372 + APE + D W G+++ E+ GR+P+ + ++ + + + P Sbjct: 181 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 240 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSEDA 399 L+ +KDP++R A Sbjct: 241 PESLHDLMCQCWRKDPEERPTFEYLQA 267 >1U5R-A nrPDB Length = 348 Score = 234 bits (597), Expect = 6e-62, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 120/308 (38%), Gaps = 19/308 (6%) Query: 106 VADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVI 165 + L Q + G + E+ ++ F L+ +G G+FG V Sbjct: 16 TTENLYFQGAMDPMPAGGRAGSLKDPDVAELFFKDDPEKL----FSDLREIGHGSFGAVY 71 Query: 166 LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF 225 ++ A+K + + ++ + E R LQ RHP + + Sbjct: 72 FARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWL 131 Query: 226 VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 285 VMEY G ++ E + L YLHS N+++RD+K N++L + Sbjct: 132 VMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH-NMIHRDVKAGNILLSEP 190 Query: 286 GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE---DNDYGRAVDWWGLGVVMYEM 342 G +K+ DFG A +F GTP ++APEV+ + Y VD W LG+ E+ Sbjct: 191 GLVKLGDFGSA----SIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIEL 246 Query: 343 MCGRLPFYNQDHEKLFELILMEEIR--FPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 + P +N + I E ++ + L+K P+ R ++ Sbjct: 247 AERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDR-----PTSE 301 Query: 401 EIMQHRFF 408 +++HRF Sbjct: 302 VLLKHRFV 309 >2OZA-A nrPDB Length = 356 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 89/290 (30%), Positives = 137/290 (47%), Gaps = 32/290 (11%) Query: 137 SLAKPKHRVTMNEFEY-LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 S + K +++++ ++LG G GKV+ + K T +A+K+L ++ A+ EV Sbjct: 6 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-QDCPKARREVELH 64 Query: 196 LTENRVLQNSRHPFLTALKYSFQT----HDRLCFVMEYANGGELFFHLSRER--VFSEDR 249 S+ P + + ++ L VME +GGELF + F+E Sbjct: 65 WR------ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 118 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATM 306 A I A+ YLHS N+ +RD+K ENL+ + +K+TDFG KE + + Sbjct: 119 ASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-L 176 Query: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL----FELIL 362 T C TP Y+APEVL Y ++ D W LGV+MY ++CG PFY+ + I Sbjct: 177 TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 236 Query: 363 MEEIRFPRT----LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 M + FP + E K L+ LLK +P QR+ E M H + Sbjct: 237 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWI 281 >3QGY-A nrPDB Length = 286 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 62/260 (23%), Positives = 116/260 (44%), Gaps = 10/260 (3%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 V + +E +++ +G G FG V L + A+K +K+ + D Sbjct: 15 VPRGSLHMVIDPSELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSEDD----F 69 Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYG 254 + E V+ HP L L +C V E+ G L +L + +F+ + Sbjct: 70 IEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMC 129 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP- 313 ++ + YL E V++RDL N ++ ++ IK++DFG+ + + D T T P Sbjct: 130 LDVCEGMAYL-EEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPV 188 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRT 371 ++ +PEV + Y D W GV+M+E+ G++P+ N+ + ++ E I + PR Sbjct: 189 KWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRL 248 Query: 372 LGPEAKSLLSGLLKKDPKQR 391 +++ K+ P+ R Sbjct: 249 ASTHVYQIMNHCWKERPEDR 268 >2J0K-A nrPDB Length = 656 Score = 234 bits (596), Expect = 9e-62, Method: Composition-based stats. Identities = 74/335 (22%), Positives = 129/335 (38%), Gaps = 18/335 (5%) Query: 76 RCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEME 135 R + T ++F + +E E +I +A+ K+ S D + + E Sbjct: 319 RLVNGAT---QSFIIRPQKEGERALPSIPKLANNEKQGVRSHTVSVS-ETDDYAEIIDEE 374 Query: 136 VSLAKPKHR---VTMNEFEYLKLLGKGTFGKVILVKEKATG---RYYAMKILKKEVIVAK 189 + P R + E + +G+G FG V + A+K K + Sbjct: 375 DTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKN--CTSD 432 Query: 190 DEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSED 248 L E ++ HP + L T + + +ME GEL L R+ Sbjct: 433 SVREKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLA 491 Query: 249 RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT 308 Y ++ +AL YL S++ V+RD+ N+++ +K+ DFGL + + Sbjct: 492 SLILYAYQLSTALAYLESKR-FVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKAS 550 Query: 309 FCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE- 365 P +++APE + + A D W GV M+E++ G PF + + I E Sbjct: 551 KGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGER 610 Query: 366 IRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 + P P SL++ DP +R A+ Sbjct: 611 LPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQ 645 >2OGV-A nrPDB Length = 317 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 24/271 (8%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY-----YAMKILKKEVIVAKDEVAHTL 196 K N ++ K LG G FGKV+ G+ A+K+LK DE + Sbjct: 32 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHA--DEKEALM 89 Query: 197 TENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE----------RVF 245 +E +++ + +H + L + + + EY G+L L R+ R Sbjct: 90 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPL 149 Query: 246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT 305 + +++ + +L S KN ++RD+ N++L KI DFGL ++ + D Sbjct: 150 ELRDLLHFSSQVAQGMAFLAS-KNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY 208 Query: 306 -MKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELIL 362 +K P +++APE + D Y D W G++++E+ G P+ F ++ Sbjct: 209 IVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLV 268 Query: 363 MEEIRF--PRTLGPEAKSLLSGLLKKDPKQR 391 + + P S++ +P R Sbjct: 269 KDGYQMAQPAFAPKNIYSIMQACWALEPTHR 299 >3KA0-A nrPDB Length = 320 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 88/290 (30%), Positives = 136/290 (46%), Gaps = 32/290 (11%) Query: 137 SLAKPKHRVTMNEFEY-LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 S + K +++++ ++LG G GKV+ + K T +A+K+L ++ A+ EV Sbjct: 4 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-QDCPKARREVELH 62 Query: 196 LTENRVLQNSRHPFLTALKYSFQT----HDRLCFVMEYANGGELFFHLSRER--VFSEDR 249 S+ P + + ++ L VME +GGELF + F+E Sbjct: 63 WR------ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 116 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATM 306 A I A+ YLHS N+ +RD+K ENL+ + +K+TDFG KE + + Sbjct: 117 ASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-L 174 Query: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL----FELIL 362 C TP Y+APEVL Y ++ D W LGV+MY ++CG PFY+ + I Sbjct: 175 TEPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 234 Query: 363 MEEIRFPRT----LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 M + FP + E K L+ LLK +P QR+ E M H + Sbjct: 235 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWI 279 >3A4O-X nrPDB Length = 286 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 55/256 (21%), Positives = 108/256 (42%), Gaps = 13/256 (5%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + + +K LG G FG+V + + + A+K LK + V L E + Sbjct: 7 AWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMS----VQAFLEEANL 61 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVS 259 ++ +H L L + + + EY G L L + + + A+I Sbjct: 62 MKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAE 121 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAP 318 + Y+ KN ++RDL+ N+++ + KI DFGL + + T + P ++ AP Sbjct: 122 GMAYI-ERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 180 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPR--TLGPE 375 E + + D W G+++YE++ G++P+ + + + + R PR E Sbjct: 181 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQG-YRMPRVENCPDE 239 Query: 376 AKSLLSGLLKKDPKQR 391 ++ K+ ++R Sbjct: 240 LYDIMKMCWKEKAEER 255 >5L6P-A nrPDB Length = 298 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 124/291 (42%), Gaps = 18/291 (6%) Query: 130 GAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR---YYAMKILKKEVI 186 G+ + ++ + + ++ + +++G G FG+V + K GR + A+K LK V Sbjct: 1 GSSDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLK--VG 58 Query: 187 VAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVF 245 + + L+E ++ HP + L+ + + E+ L L + F Sbjct: 59 YTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQF 118 Query: 246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA- 304 + + I + + YL SE N V+RDL N++++ + K++DFGL + D + Sbjct: 119 TVIQLVGMLRGIAAGMKYL-SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSD 177 Query: 305 -TMKTFCG---TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFE 359 T + G + APE + + A D W G+VM+E+M G P+++ ++ + Sbjct: 178 PTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIN 237 Query: 360 LILMEEIRFPRT--LGPEAKSLLSGLLKKDPKQR--LGGGSEDAKEIMQHR 406 + ++ R P L+ +D R +++++ Sbjct: 238 AV-EQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNP 287 >1G3N-A nrPDB Length = 326 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 75/314 (23%), Positives = 128/314 (40%), Gaps = 47/314 (14%) Query: 149 EFEYLKLLGKGTFGKVILVKE-KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR- 206 ++E + +G+G +GKV ++ K GR+ A+K ++ + ++ T+ E VL++ Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLS-TIREVAVLRHLET 70 Query: 207 --HPFLTALKYSFQ-----THDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEI 257 HP + L +L V E+ + +L +L + E + + ++ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 + LD+LHS + VV+RDLK +N+++ G IK+ DFGL + + + T Y A Sbjct: 130 LRGLDFLHSHR-VVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALTSVVVTLWYRA 187 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-----EEIRFPRTL 372 PEVL + Y VD W +G + EM + F IL E +PR + Sbjct: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 373 --------GPEA--------------KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 A K LL L +P +R+ S + H +F Sbjct: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS-----ALSHPYFQD 302 Query: 411 IVWQHVYEKKLSPP 424 + PP Sbjct: 303 LERCKENLDSHLPP 316 >3FME-A nrPDB Length = 290 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 68/277 (24%), Positives = 121/277 (43%), Gaps = 19/277 (6%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV-L 202 V ++ E + LG+G +G V ++ +G+ A+K ++ V E L + + + Sbjct: 3 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLDISM 60 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH---LSRERVFSEDRARFYGAEIVS 259 + PF + + ME + F+ + + + ED IV Sbjct: 61 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 120 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 AL++LHS+ +V++RD+K N++++ G +K+ DFG+ + D A G Y+APE Sbjct: 121 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAK-DIDAGCKPYMAPE 179 Query: 320 VL----EDNDYGRAVDWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEEIRFP-RTL 372 + Y D W LG+ M E+ R P+ + ++L +++ + P Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF 239 Query: 373 GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 E S LKK+ K+R E+MQH FF Sbjct: 240 SAEFVDFTSQCLKKNSKER-----PTYPELMQHPFFT 271 >5X02-A nrPDB Length = 347 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 69/334 (20%), Positives = 134/334 (40%), Gaps = 46/334 (13%) Query: 113 QEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE--- 169 + + +M +GS + + K E+ K+LG G FGKV+ Sbjct: 13 ESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGI 72 Query: 170 KATG--RYYAMKILKKEVIVAKDEVAHTLTENRVLQNS-RHPFLTALKYSFQTHDRLCFV 226 TG A+K+LK++ ++ E ++E +++ H + L + + + Sbjct: 73 SKTGVSIQVAVKMLKEKADSSEREA--LMSELKMMTQLGSHENIVNLLGACTLSGPIYLI 130 Query: 227 MEYANGGELFFHLSRER-VFSEDRARF----------------------YGAEIVSALDY 263 EY G+L +L +R FSED + + ++ +++ Sbjct: 131 FEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEF 190 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD-GATMKTFCGTP-EYLAPEVL 321 L K+ V+RDL N+++ +KI DFGL ++ + D ++ P +++APE L Sbjct: 191 L-EFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESL 249 Query: 322 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTL--GPEAKS 378 + Y D W G++++E+ G P+ + F ++ + + E Sbjct: 250 FEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYI 309 Query: 379 LLSGLLKKDPKQR---------LGGGSEDAKEIM 403 ++ D ++R LG DA+E M Sbjct: 310 IMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAM 343 >3C1X-A nrPDB Length = 373 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 65/310 (20%), Positives = 129/310 (41%), Gaps = 18/310 (5%) Query: 102 AIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYL----KLLG 157 +I+ ++ L K+ E + G+ + + + L + V + + +++G Sbjct: 39 SIEELSTSLYKKAGSENLYFQGANTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIG 98 Query: 158 KGTFGKVI---LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +G FG V L+ + A+K L + I EV+ LTE ++++ HP + +L Sbjct: 99 RGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHPNVLSLL 156 Query: 215 YSF-QTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLHSEKNVVY 272 ++ V+ Y G+L + E + +G ++ + +L S+K V+ Sbjct: 157 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKK-FVH 215 Query: 273 RDLKLENLMLDKDGHIKITDFGLCKEGIK---DGATMKTFCGTP-EYLAPEVLEDNDYGR 328 RDL N MLD+ +K+ DFGL ++ D KT P +++A E L+ + Sbjct: 216 RDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFTT 275 Query: 329 AVDWWGLGVVMYEMMC-GRLPFYNQDHEKL-FELILMEEIRFPRTLGPEAKSLLSGLLKK 386 D W GV+++E+M G P+ + + + L+ + P ++ Sbjct: 276 KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP 335 Query: 387 DPKQRLGGGS 396 + R Sbjct: 336 KAEMRPSFSE 345 >6FEX-A nrPDB Length = 321 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 69/316 (21%), Positives = 116/316 (36%), Gaps = 51/316 (16%) Query: 135 EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK----------------EKATGRYYAM 178 V P+ + + + LG+G FG+V L + K A+ Sbjct: 3 AVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV 62 Query: 179 KILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238 KIL+ + K+ L E +++ + P + L D LC + +Y G+L Sbjct: 63 KILRPDA--TKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQF 120 Query: 239 LSRERV-------------FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 285 LS ++ S A+I S + YL + N V+RDL N ++ ++ Sbjct: 121 LSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLATRNCLVGEN 179 Query: 286 GHIKITDFGLCKEGI-KDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYE-- 341 IKI DFG+ + D ++ P ++A E + + A D W GV ++E Sbjct: 180 FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 239 Query: 342 MMCGRLPFYNQDHEKLFELI--------LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 M+C PF E++ E + P L+ ++ +QR Sbjct: 240 MLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPP 299 Query: 394 GGSEDAKEIMQHRFFA 409 HRF A Sbjct: 300 FSQL-------HRFLA 308 >2GCD-A nrPDB Length = 309 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 65/264 (24%), Positives = 110/264 (41%), Gaps = 15/264 (5%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 F L+ +G G+FG V ++ A+K + + ++ + E R LQ RHP Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + + VMEY G ++ E + L YLHS N Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH-N 135 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE---DNDY 326 +++RD+K N++L + G +K+ DFG A +F GTP ++APEV+ + Y Sbjct: 136 MIHRDVKAGNILLSEPGLVKLGDFGSA----SIMAPANSFVGTPYWMAPEVILAMDEGQY 191 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIR--FPRTLGPEAKSLLSGLL 384 VD W LG+ E+ + P +N + I E ++ + L Sbjct: 192 DGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCL 251 Query: 385 KKDPKQRLGGGSEDAKEIMQHRFF 408 +K P+ R ++ +++HRF Sbjct: 252 QKIPQDR-----PTSEVLLKHRFV 270 >1LUF-A nrPDB Length = 343 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 62/283 (21%), Positives = 103/283 (36%), Gaps = 36/283 (12%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATG-----RYYAMKILKKEVIVAKDEVAHTLTE 198 N EY++ +G+G FG+V + A+K+LK+E + D A E Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEA--SADMQADFQRE 100 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR----------------- 241 ++ +P + L +C + EY G+L L Sbjct: 101 AALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTR 160 Query: 242 -------ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 S ++ + + YL SE+ V+RDL N ++ ++ +KI DFG Sbjct: 161 ARVSSPGPPPLSCAEQLCIARQVAAGMAYL-SERKFVHRDLATRNCLVGENMVVKIADFG 219 Query: 295 LCKEGIKDGATMKTF--CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYN 351 L + ++ PE + N Y D W GVV++E+ G P+Y Sbjct: 220 LSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 279 Query: 352 QDHEKLFELILMEEI-RFPRTLGPEAKSLLSGLLKKDPKQRLG 393 HE++ + I P E +L+ K P R Sbjct: 280 MAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPS 322 >3FI2-A nrPDB Length = 353 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 67/318 (21%), Positives = 120/318 (37%), Gaps = 61/318 (19%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + ++ LK +G G G V + R A+K L + + E +++ Sbjct: 21 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKC 79 Query: 205 SRHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 H + +L F L VME + L + E +R + +++ Sbjct: 80 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQML 136 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 + +LHS +++RDLK N+++ D +KI DFGL + M + T Y AP Sbjct: 137 CGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAP 194 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME-------------- 364 EV+ Y VD W +G +M EM+ ++ F +D+ + ++ + Sbjct: 195 EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 254 Query: 365 -------------EIRFPRTLGP---------------EAKSLLSGLLKKDPKQRLGGGS 396 + FP+ +A+ LLS +L DP +R+ Sbjct: 255 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS--- 311 Query: 397 EDAKEIMQHRFFAGIVWQ 414 + +QH + VW Sbjct: 312 --VDDALQHPYIN--VWY 325 >6BSD-A nrPDB Length = 876 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 70/334 (20%), Positives = 118/334 (35%), Gaps = 57/334 (17%) Query: 123 GSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK-------------- 168 G+ V P+ + + + LG+G FG+V L + Sbjct: 546 GNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPL 605 Query: 169 --EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFV 226 K A+KIL+ + K+ L E +++ + P + L D LC + Sbjct: 606 NVRKGHPLLVAVKILRPDA--TKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMI 663 Query: 227 MEYANGGELFFHLSRERV-------------------FSEDRARFYGAEIVSALDYLHSE 267 +Y G+L LS ++ S A+I S + YL + Sbjct: 664 TDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL-AT 722 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI-KDGATMKTFCGTP-EYLAPEVLEDND 325 N V+RDL N ++ ++ IKI DFG+ + D ++ P ++A E + Sbjct: 723 LNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGK 782 Query: 326 YGRAVDWWGLGVVMYE--MMCGRLPFYNQDHEKLFELI--------LMEEIRFPRTLGPE 375 + A D W GV ++E M+C PF E++ E + P Sbjct: 783 FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQG 842 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 L+ ++ +QR HRF A Sbjct: 843 LYELMLRCWSRESEQRPPFSQL-------HRFLA 869 >1UA2-A nrPDB Length = 346 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 118/295 (40%), Gaps = 39/295 (13%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIV-AKDEVAHT-LTENRVLQNS 205 +E L LG+G F V ++K T + A+K +K AKD + T L E ++LQ Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYL 264 HP + L +F + V ++ +L + V + + Y + L+YL Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED- 323 H + +++RDLK NL+LD++G +K+ DFGL K T Y APE+L Sbjct: 129 H-QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-----EEIRFPRTLG----- 373 YG VD W +G ++ E++ I E ++P Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 Query: 374 ------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 + L+ GL +P R+ A + ++ ++F+ Sbjct: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSN 297 >5Z33-A nrPDB Length = 425 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 79/336 (23%), Positives = 129/336 (38%), Gaps = 61/336 (18%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + + K LG+G +G V T A+K + V K L E ++LQ+ Sbjct: 28 IVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV-TNVFSKKILAKRALREIKLLQH 86 Query: 205 SR-HPFLTALKYS----FQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 R H +T L + E +L + + ++ + + +I+ Sbjct: 87 FRGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAHFQSFIYQILC 145 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA----TMKTFCGTPEY 315 L Y+HS NV++RDLK NL+++ D +KI DFGL + D M + T Y Sbjct: 146 GLKYIHS-ANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWY 204 Query: 316 LAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL------------ 362 APE+ L Y +A+D W +G ++ E++ GR F +D+ IL Sbjct: 205 RAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLS 264 Query: 363 ----------------MEEIRFPRTLG---PEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403 M + FP P+A LL +L DP R+ ++ + Sbjct: 265 RIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRIS-----VEQAL 319 Query: 404 QHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439 +H + H++ P P T FD Sbjct: 320 EHPYL------HIWHDASDEPDCPT------TFNFD 343 >3KUL-B nrPDB Length = 325 Score = 231 bits (590), Expect = 5e-61, Method: Composition-based stats. Identities = 63/259 (24%), Positives = 105/259 (40%), Gaps = 14/259 (5%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY---YAMKILKKEVIVAKDEVAHTLTEN 199 + + K++G G G+V + + G+ A+K LK + + L+E Sbjct: 44 REIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALK--AGYTERQRRDFLSEA 101 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEIV 258 ++ HP + L+ V EY G L L F+ + + Sbjct: 102 SIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVG 161 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEY 315 + + YL S+ V+RDL N+++D + K++DFGL + D T G + Sbjct: 162 AGMRYL-SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRW 220 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYE-MMCGRLPFYNQDHEKLFELILMEEIRFPRTL-G 373 APE + + A D W GVVM+E + G P++N + + + E R P + Sbjct: 221 TAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSV-EEGYRLPAPMGC 279 Query: 374 PEA-KSLLSGLLKKDPKQR 391 P A L+ KD QR Sbjct: 280 PHALHQLMLDCWHKDRAQR 298 >3KRL-A nrPDB Length = 335 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 112/277 (40%), Gaps = 30/277 (10%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY-----YAMKILKKEVIVAKDEVAHTL 196 K N ++ K LG G FGKV+ G+ A+K+LK DE + Sbjct: 40 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHA--DEKEALM 97 Query: 197 TENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV----------- 244 +E +++ + +H + L + + + EY G+L L R+R Sbjct: 98 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSH 157 Query: 245 -----FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299 S + +++ + +L S KN ++RD+ N++L KI DFGL ++ Sbjct: 158 NPEEQLSSRDLLHFSSQVAQGMAFLAS-KNCIHRDVAARNVLLTNGHVAKIGDFGLARDI 216 Query: 300 IKDGAT-MKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEK 356 + D +K P +++APE + D Y D W G++++E+ G P+ Sbjct: 217 MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNS 276 Query: 357 LFELILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQR 391 F ++ + + P S++ +P R Sbjct: 277 KFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 313 >4O2Z-A nrPDB Length = 377 Score = 230 bits (588), Expect = 7e-61, Method: Composition-based stats. Identities = 75/356 (21%), Positives = 135/356 (37%), Gaps = 56/356 (15%) Query: 114 EEEEMDFRSGS-----PSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168 E + G+ P + VS P +++ LK+LG G +G Sbjct: 9 SGRENLYFQGNQELSVPKIVGDFKVYNVS-GSPFE--VPSKYTLLKILGMGAYGIACSCL 65 Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA-------LKYSFQTHD 221 + TG ++K + +V ++ L E +++ H L LK + + + Sbjct: 66 DGDTGEKVSIKKCR-DVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFE 124 Query: 222 RLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLM 281 + V + ++ L +V E +++ +I+ L YLHS NV +RDLK NL+ Sbjct: 125 DVYVVTPLMD-VDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHS-ANVAHRDLKPANLV 182 Query: 282 LDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMY 340 + +KI DFGL + + + + T Y PE+L +N +Y AVD W +G + Sbjct: 183 TNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFA 242 Query: 341 EMMCGRLPFYNQDHEKLFELILM------------------------EEIRFPRTLG--- 373 EM + F ++ +I + P+ + Sbjct: 243 EMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLA 302 Query: 374 --PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSP-PFK 426 E LS + DP +R A +++ H + A + ++ P PF Sbjct: 303 GNTEGIDFLSKMWTLDPSKR-----PTAADMLAHPYLAHL--HDEEDEPTCPCPFL 351 >2VWV-A nrPDB Length = 302 Score = 230 bits (587), Expect = 9e-61, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 109/252 (43%), Gaps = 14/252 (5%) Query: 151 EYLKLLGKGTFGKVILVKEKATGRY---YAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + +++G G FG+V + KA G+ A+K LK + + L+E ++ H Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGG--YTERQRREFLSEASIMGQFEH 76 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYLHS 266 P + L+ + + E+ G L L + F+ + I S + YL + Sbjct: 77 PNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYL-A 135 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCK---EGIKDGATMKTFCG--TPEYLAPEVL 321 E + V+RDL N++++ + K++DFGL + E D + G + APE + Sbjct: 136 EMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAI 195 Query: 322 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSL 379 + A D W G+VM+E+M G P+++ ++ + I + + P L Sbjct: 196 AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQL 255 Query: 380 LSGLLKKDPKQR 391 + +KD R Sbjct: 256 MLDCWQKDRNAR 267 >4NST-A nrPDB Length = 351 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 75/332 (22%), Positives = 135/332 (40%), Gaps = 60/332 (18%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +++F+ + ++G+GT+G+V K+K TG A+K ++ + + + E ++L+ Sbjct: 11 CVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPI-TAIREIKILRQL 69 Query: 206 RHPFLTALKYSFQTH----------DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 H + +K V EY + + S FSED + + Sbjct: 70 IHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMK 129 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT-FCGTPE 314 +++ L+Y H +KN ++RD+K N++L+ G IK+ DFGL + + + T T Sbjct: 130 QLMEGLEYCH-KKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 188 Query: 315 YLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRL-------------------------- 347 Y PE+L Y A+D W G ++ E+ + Sbjct: 189 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 248 Query: 348 ------PFYN-QDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 P++N +K + L EE F + A LL +L DP +R A+ Sbjct: 249 PDVIKLPYFNTMKPKKQYRRRLREEFSF---IPSAALDLLDHMLTLDPSKRC-----TAE 300 Query: 401 EIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSE 432 + +Q F + V K++PP P Sbjct: 301 QTLQSDFL-----KDVELSKMAPPDLPHWQDC 327 >3BEA-A nrPDB Length = 333 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 111/275 (40%), Gaps = 28/275 (10%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY-----YAMKILKKEVIVAKDEVAHTL 196 K N ++ K LG G FGKV+ G+ A+K+LK DE + Sbjct: 40 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHA--DEKEALM 97 Query: 197 TENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV----------- 244 +E +++ + +H + L + + + EY G+L L R+ Sbjct: 98 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIA 157 Query: 245 ---FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 S + +++ + +L S KN ++RD+ N++L KI DFGL ++ + Sbjct: 158 NSTLSTRDLLHFSSQVAQGMAFLAS-KNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN 216 Query: 302 DGAT-MKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLF 358 D +K P +++APE + D Y D W G++++E+ G P+ F Sbjct: 217 DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF 276 Query: 359 ELILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQR 391 ++ + + P S++ +P R Sbjct: 277 YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 311 >3CJF-A nrPDB Length = 309 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 120/294 (40%), Gaps = 32/294 (10%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK-----EKATGRYYAMKILKKEVIVAKD 190 + K + K LG+G FG+VI + AT R A+K+LK+ Sbjct: 15 LPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGA--THS 72 Query: 191 EVAHTLTENRVL-QNSRHPFLTALKYSFQ-THDRLCFVMEYANGGELFFHLSRER----- 243 E ++E ++L H + L + L ++E+ G L +L +R Sbjct: 73 EHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVP 132 Query: 244 -------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC 296 + + Y ++ +++L S K ++RDL N++L + +KI DFGL Sbjct: 133 YKDLYKDFLTLEHLICYSFQVAKGMEFLASRK-CIHRDLAARNILLSEKNVVKICDFGLA 191 Query: 297 KEGIKDGATMK--TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQD 353 ++ KD ++ +++APE + D Y D W GV+++E+ G P+ Sbjct: 192 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 251 Query: 354 HEKLFELILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 ++ F L E R P PE + +P QR E+++H Sbjct: 252 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR-----PTFSELVEH 300 >6E2O-A nrPDB Length = 295 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 71/270 (26%), Positives = 126/270 (46%), Gaps = 18/270 (6%) Query: 149 EFEYLK-----LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 ++EY + +LGKGT+G V ++ + A+K + + + E + + Sbjct: 18 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHE---EIALHK 74 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFS--EDRARFYGAEIVSA 260 + +H + SF + + ME GG L L + E FY +I+ Sbjct: 75 HLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEG 134 Query: 261 LDYLHSEKNVVYRDLKLENLMLDK-DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 L YLH + +V+RD+K +N++++ G +KI+DFG K +TF GT +Y+APE Sbjct: 135 LKYLH-DNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPE 193 Query: 320 VLED--NDYGRAVDWWGLGVVMYEMMCGRLPFY--NQDHEKLFEL-ILMEEIRFPRTLGP 374 +++ YG+A D W LG + EM G+ PFY + +F++ + P ++ Sbjct: 194 IIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSA 253 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 EAK+ + + DP +R E ++ Sbjct: 254 EAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >4XUF-A nrPDB Length = 297 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 119/293 (40%), Gaps = 37/293 (12%) Query: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKE---KATG--RYYAMKILKKEVIVAKDEVAH 194 K E+ K+LG G FGKV+ TG A+K+LK++ ++ E Sbjct: 1 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA-- 58 Query: 195 TLTENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARF 252 ++E +++ H + L + + + EY G+L +L +R FSED + Sbjct: 59 LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEY 118 Query: 253 ----------------------YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290 + ++ +++L K+ V+RDL N+++ +KI Sbjct: 119 ENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFL-EFKSCVHRDLAARNVLVTHGKVVKI 177 Query: 291 TDFGLCKEGIKD-GATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRL 347 DFGL ++ + D ++ P +++APE L + Y D W G++++E+ G Sbjct: 178 CDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVN 237 Query: 348 PFYNQDHEKLFELILMEEIRFPRTL--GPEAKSLLSGLLKKDPKQRLGGGSED 398 P+ + F ++ + + E ++ D ++R + Sbjct: 238 PYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLT 290 >4R7H-A nrPDB Length = 343 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 62/333 (18%), Positives = 119/333 (35%), Gaps = 37/333 (11%) Query: 100 TTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKG 159 G K + + ++ + K N ++ K LG G Sbjct: 2 KKGHHHHHHGQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAG 61 Query: 160 TFGKVILVKEKATGRY-----YAMKILKKEVIVAKDEVAHTLTENRVLQNS-RHPFLTAL 213 FGKV+ G+ A+K+LK DE ++E +++ + +H + L Sbjct: 62 AFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHA--DEKEALMSELKIMSHLGQHENIVNL 119 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRE-----------------------RVFSEDRA 250 + + + EY G+L L R+ R Sbjct: 120 LGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDL 179 Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT-MKTF 309 + +++ + +L S KN ++RD+ N++L KI DFGL ++ + D +K Sbjct: 180 LHFSSQVAQGMAFLAS-KNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGN 238 Query: 310 CGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIR 367 P +++APE + D+ Y D W G++++E+ G P+ F ++ + + Sbjct: 239 ARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ 298 Query: 368 F--PRTLGPEAKSLLSGLLKKDPKQRLGGGSED 398 P S++ +P R Sbjct: 299 MAQPAFAPKNIYSIMQACWALEPTHRPTFQQIT 331 >5KKR-C nrPDB Length = 395 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 72/313 (23%), Positives = 124/313 (39%), Gaps = 53/313 (16%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQIIRELQVLHECNS 125 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P++ +F + + ME+ +GG L L + E ++ L YL + Sbjct: 126 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 185 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +++RD+K N++++ G IK+ DFG+ + I + +F GT Y++PE L+ Y Sbjct: 186 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSFVGTRSYMSPERLQGTHYS 243 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEK------------------------------- 356 D W +G+ + EM GR P D ++ Sbjct: 244 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 303 Query: 357 --------LFEL----ILMEEIRFPR-TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403 +FEL + + P E + ++ L K+P +R D K++M Sbjct: 304 MDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAER-----ADLKQLM 358 Query: 404 QHRFFAGIVWQHV 416 H F + V Sbjct: 359 VHAFIKRSDAEEV 371 >3LM0-A nrPDB Length = 327 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 82/284 (28%), Positives = 140/284 (49%), Gaps = 20/284 (7%) Query: 147 MNEFEYL--KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 N F L K LG+G F V K+TG+ YA K LKK +D A L E VL+ Sbjct: 26 FNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRR-GQDCRAEILHEIAVLEL 84 Query: 205 SR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSAL 261 ++ P + L ++ + ++EYA GGE+F E + SE+ +I+ + Sbjct: 85 AKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGV 144 Query: 262 DYLHSEKNVVYRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 YLH + N+V+ DLK +N++L G IKI DFG+ ++ I ++ GTPEYLAP Sbjct: 145 YYLH-QNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRK-IGHACELREIMGTPEYLAP 202 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGP 374 E+L + A D W +G++ Y ++ PF +D+++ + I + + ++ Sbjct: 203 EILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQ 262 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 418 A + LL K+P++R A+ + H + +++++ Sbjct: 263 LATDFIQSLLVKNPEKR-----PTAEICLSHSWLQQWDFENLFH 301 >3GC9-A nrPDB Length = 370 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 76/371 (20%), Positives = 143/371 (38%), Gaps = 58/371 (15%) Query: 115 EEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR 174 M SG +G E++ + + L+ +G G +G V + + Sbjct: 1 GSHMLEMSGP---RAGFYRQELNKTVWE---VPQRLQGLRPVGSGAYGSVCSAYDARLRQ 54 Query: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHD------RLCFVME 228 A+K L + + T E R+L++ +H + L F + V Sbjct: 55 KVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTT 113 Query: 229 YANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI 288 G +L + + + S++ +F +++ L Y+HS +++RDLK N+ +++D + Sbjct: 114 LM-GADLNN-IVKSQALSDEHVQFLVYQLLRGLKYIHS-AGIIHRDLKPSNVAVNEDSEL 170 Query: 289 KITDFGLCKEGIKDGATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRL 347 +I DFGL ++ M + T Y APE+ L Y + VD W +G +M E++ G+ Sbjct: 171 RILDFGLARQA---DEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKA 227 Query: 348 PFYNQDHEKLFELILMEEIRFPRTL-------------------------------GPEA 376 F D+ + I+ + P A Sbjct: 228 LFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLA 287 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 436 LL +L D QR+ A E + H +F+ + ++ + P+ V ++ T Sbjct: 288 IDLLGRMLVLDSDQRVS-----AAEALAHAYFSQ--YHDPEDEPEAEPYDESVEAKERTL 340 Query: 437 YFDEEFTAQMI 447 +E T Q + Sbjct: 341 EEWKELTYQEV 351 >2PL0-A nrPDB Length = 289 Score = 227 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 108/255 (42%), Gaps = 12/255 (4%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + V + ++ LG G FG+V + + A+K LK+ + L E + Sbjct: 17 EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTK-VAVKSLKQGSMSPD----AFLAEANL 71 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEIVS 259 ++ +H L L T + + + EY G L L + ++ A+I Sbjct: 72 MKQLQHQRLVRLYAVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 130 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAP 318 + ++ E+N ++RDL+ N+++ KI DFGL + + T + P ++ AP Sbjct: 131 GMAFI-EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAP 189 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEA 376 E + + D W G+++ E++ GR+P+ + ++ + + + P E Sbjct: 190 EAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEEL 249 Query: 377 KSLLSGLLKKDPKQR 391 L+ K+ P+ R Sbjct: 250 YQLMRLCWKERPEDR 264 >3G0E-A nrPDB Length = 336 Score = 227 bits (580), Expect = 7e-60, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 112/294 (38%), Gaps = 37/294 (12%) Query: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILV-----KEKATGRYYAMKILKKEVIVAKDEVAH 194 K N + K LG G FGKV+ + A+K+LK + + E Sbjct: 38 DHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREA-- 95 Query: 195 TLTENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER---------- 243 ++E +VL H + L + + EY G+L L R+R Sbjct: 96 LMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSP 155 Query: 244 --------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGL 295 + + ++ + +L S KN ++RDL N++L KI DFGL Sbjct: 156 AIMEDDELALDLEDLLSFSYQVAKGMAFLAS-KNCIHRDLAARNILLTHGRITKICDFGL 214 Query: 296 CKEGIKD-GATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ 352 ++ D +K P +++APE + + Y D W G+ ++E+ G P+ Sbjct: 215 ARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM 274 Query: 353 DHEKLFELILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 + F ++ E R P E ++ DP +R K+I+Q Sbjct: 275 PVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKR-----PTFKQIVQ 323 >2HK5-A nrPDB Length = 270 Score = 227 bits (580), Expect = 7e-60, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 107/256 (41%), Gaps = 14/256 (5%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILV-KEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 + + K LG G FG+V + K T A+K +K + V L E Sbjct: 9 AWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMS----VEAFLAEAN 62 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF--SEDRARFYGAEIV 258 V++ +H L L T + + + E+ G L L + + + A+I Sbjct: 63 VMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIA 121 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLA 317 + ++ ++N ++RDL+ N+++ KI DFGL + + T + P ++ A Sbjct: 122 EGMAFI-EQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTA 180 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPE 375 PE + + D W G+++ E++ GR+P+ + ++ + + P E Sbjct: 181 PEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEE 240 Query: 376 AKSLLSGLLKKDPKQR 391 +++ K P++R Sbjct: 241 LYNIMMRCWKNRPEER 256 >3EQC-A nrPDB Length = 360 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 72/313 (23%), Positives = 124/313 (39%), Gaps = 53/313 (16%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + LG G G V V K +G A K++ E+ A + E +VL Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR--NQIIRELQVLHECNS 90 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P++ +F + + ME+ +GG L L + E ++ L YL + Sbjct: 91 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREK 150 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +++RD+K N++++ G IK+ DFG+ + I + +F GT Y++PE L+ Y Sbjct: 151 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSFVGTRSYMSPERLQGTHYS 208 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEK------------------------------- 356 D W +G+ + EM GR P D ++ Sbjct: 209 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNKFG 268 Query: 357 --------LFEL----ILMEEIRFPR-TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIM 403 +FEL + + P E + ++ L K+P +R D K++M Sbjct: 269 MDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER-----ADLKQLM 323 Query: 404 QHRFFAGIVWQHV 416 H F + V Sbjct: 324 VHAFIKRSDAEEV 336 >3ALO-A nrPDB Length = 327 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 126/285 (44%), Gaps = 25/285 (8%) Query: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199 + T + + L +G+G +G V + K +G+ A+K ++ + K++ + + Sbjct: 14 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIR-STVDEKEQKQLLMDLD 72 Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR------ERVFSEDRARFY 253 V+++S P++ + ME + F + + V E+ Sbjct: 73 VVMRSSDCPYIVQFYGALFREGDCWICMELMSTS--FDKFYKYVYSVLDDVIPEEILGKI 130 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP 313 V AL++L +++RD+K N++LD+ G+IK+ DFG+ + + A + G Sbjct: 131 TLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRD-AGCR 189 Query: 314 EYLAPEVL----EDNDYGRAVDWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEEIR 367 Y+APE + Y D W LG+ +YE+ GR P+ +N ++L +++ + + Sbjct: 190 PYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQ 249 Query: 368 FP----RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 R P + ++ L KD +R KE+++H F Sbjct: 250 LSNSEEREFSPSFINFVNLCLTKDESKR-----PKYKELLKHPFI 289 >6E4F-A nrPDB Length = 290 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 119/280 (42%), Gaps = 23/280 (8%) Query: 117 EMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY- 175 E + G+ G+ E++ + +LK LG G FG V K + G+Y Sbjct: 11 ENLYFQGTAGLGYGSWEIDP-----------KDLTFLKELGTGQFGVVKYGKWR--GQYD 57 Query: 176 YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL 235 A+K++K+ + + + E +V+ N H L L + + EY G L Sbjct: 58 VAIKMIKEGSMSEDE----FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCL 113 Query: 236 FFHLSRER-VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 +L R F + ++ A++YL S K ++RDL N +++ G +K++DFG Sbjct: 114 LNYLREMRHRFQTQQLLEMCKDVCEAMEYLES-KQFLHRDLAARNCLVNDQGVVKVSDFG 172 Query: 295 LCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ 352 L + + D T P + PEVL + + D W GV+M+E+ G++P+ Sbjct: 173 LSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERF 232 Query: 353 DHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQR 391 + + E I + P + +++ + +R Sbjct: 233 TNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADER 272 >5EFQ-A nrPDB Length = 347 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 72/329 (21%), Positives = 133/329 (40%), Gaps = 54/329 (16%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 +++F+ + ++G+GT+G+V ++K TG A+K ++ + + + E ++L+ Sbjct: 9 CVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPI-TAIREIKILRQL 67 Query: 206 RHPFLTALKYSFQTHDR----------LCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 H + +K + V EY + + S F+E+ + + Sbjct: 68 THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMR 127 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT-FCGTPE 314 +++ LDY H +KN ++RD+K N++L+ G IK+ DFGL + + + T T Sbjct: 128 QLMEGLDYCH-KKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLW 186 Query: 315 YLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI------------ 361 Y PE+L Y A+D W G ++ E+ + F ELI Sbjct: 187 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 246 Query: 362 -----------LMEEIRFPRTLGPE-------AKSLLSGLLKKDPKQRLGGGSEDAKEIM 403 + + ++ R L E A L +L DP +R A++ + Sbjct: 247 PDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRC-----TAEQAL 301 Query: 404 QHRFFAGIVWQHVYEKKLSPPFKPQVTSE 432 Q F + V K+ PP P Sbjct: 302 QCEFL-----RDVEPSKMPPPDLPLWQDC 325 >5NGU-A nrPDB Length = 381 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 70/351 (19%), Positives = 134/351 (38%), Gaps = 53/351 (15%) Query: 117 EMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYY 176 E + GS + A + + + + L +G+G +G V + Sbjct: 11 ENLYFQGSHMAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRV 70 Query: 177 AMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSF-----QTHDRLCFVMEYAN 231 A+K + + TL E ++L RH + + + + V + Sbjct: 71 AIKKI--SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLME 128 Query: 232 GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKIT 291 +L+ L + + S D ++ +I+ L Y+HS NV++RDLK NL+L+ +KI Sbjct: 129 -TDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLLNTTCDLKIC 185 Query: 292 DFGLCKEGIKDGAT---MKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRL 347 DFGL + D + + T Y APE+ L Y +++D W +G ++ EM+ R Sbjct: 186 DFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRP 245 Query: 348 PFYNQDHEKLFELIL----------------------------MEEIRFPRTLG---PEA 376 F + + IL ++ + R +A Sbjct: 246 IFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKA 305 Query: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKL-SPPFK 426 LL +L +P +R+ + ++ + H + + ++ + PFK Sbjct: 306 LDLLDKMLTFNPHKRI-----EVEQALAHPYLEQ--YYDPSDEPIAEAPFK 349 >3GC0-A nrPDB Length = 329 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 68/325 (20%), Positives = 128/325 (39%), Gaps = 46/325 (14%) Query: 126 SDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 185 + G M VS A +++ + + LG+GT+G+V + T A+K ++ E Sbjct: 14 AQTQGPGSMSVSAAPSA--TSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEH 71 Query: 186 IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF 245 + + E +L+ +H + LK + RL + EYA +L ++ + Sbjct: 72 -EEEGVPGTAIREVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDV 129 Query: 246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML-----DKDGHIKITDFGLCKEGI 300 S + + ++++ +++ HS + ++RDLK +NL+L + +KI DFGL + Sbjct: 130 SMRVIKSFLYQLINGVNFCHSRR-CLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFG 188 Query: 301 KDGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 359 T Y PE+L Y +VD W + + EM+ F Sbjct: 189 IPIRQFTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLF 248 Query: 360 LILME------------------EIRFPRTLGPEAKSLL------------SGLLKKDPK 389 I + FP+ G K +L + +L+ DP Sbjct: 249 KIFEVLGLPDDTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPV 308 Query: 390 QRLGGGSEDAKEIMQHRFFAGIVWQ 414 +R+ AK ++H +F+ + Sbjct: 309 KRIS-----AKNALEHPYFSHNDFD 328 >5GRN-A nrPDB Length = 356 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 61/310 (19%), Positives = 118/310 (38%), Gaps = 41/310 (13%) Query: 122 SGSPSDNSGAEEMEVSLA-KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR-----Y 175 S SP + + L + + ++LG G FGKV+ R Sbjct: 19 SISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMK 78 Query: 176 YAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGE 234 A+K+LK + E ++E +++ + H + L + + + EY G+ Sbjct: 79 VAVKMLKPTARSS--EKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGD 136 Query: 235 LFFHLSRER--------------------------VFSEDRARFYGAEIVSALDYLHSEK 268 L +L + R + + ++ +++L S K Sbjct: 137 LVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLAS-K 195 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK--TFCGTPEYLAPEVLEDNDY 326 N V+RDL N++L + +KI DFGL ++ + D + + +++APE + DN Y Sbjct: 196 NCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLY 255 Query: 327 GRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRF--PRTLGPEAKSLLSGL 383 D W G++++E+ G P+ + F + R P E ++ Sbjct: 256 TTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKC 315 Query: 384 LKKDPKQRLG 393 +P++R Sbjct: 316 WNSEPEKRPS 325 >3QUP-A nrPDB Length = 323 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 119/282 (42%), Gaps = 23/282 (8%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATG---RYYAMKILKKEVIVAKDEVAHTLTENRV 201 + +F ++LGKG FG V + K A+K+LK ++I + D + L E Sbjct: 20 IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSD-IEEFLREAAC 78 Query: 202 LQNSRHPFLTALKYSFQT---HDRL---CFVMEYANGGELFFHLSRERV------FSEDR 249 ++ HP + L RL ++ + G+L L R+ Sbjct: 79 MKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQT 138 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309 + +I ++YL S +N ++RDL N ML +D + + DFGL ++ + Sbjct: 139 LVRFMVDIACGMEYL-SSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGC 197 Query: 310 CG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFE-LILMEE 365 ++LA E L DN Y D W GV M+E+M G+ P+ ++ +++ LI Sbjct: 198 ASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNR 257 Query: 366 IRFPRTLGPEAKSLLSGLLKKDPKQR--LGGGSEDAKEIMQH 405 ++ P E L+ DPKQR + + I+ H Sbjct: 258 LKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH 299 >4PDO-A nrPDB Length = 299 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 57/248 (22%), Positives = 106/248 (42%), Gaps = 13/248 (5%) Query: 154 KLLGKGTFGKVILVKEK-ATGRY---YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 K++G G FG+V K ++G+ A+K LK + + L E ++ H Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLK--AGYTEKQRVDFLGEAGIMGQFSHHN 97 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYLHSEK 268 + L+ + + + EY G L L ++ FS + I + + YL + Sbjct: 98 IIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYL-ANM 156 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVLEDND 325 N V+RDL N++++ + K++DFGL + D T G + APE + Sbjct: 157 NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRK 216 Query: 326 YGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGL 383 + A D W G+VM+E+M G P++ + ++ + I + P L+ Sbjct: 217 FTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQC 276 Query: 384 LKKDPKQR 391 +++ +R Sbjct: 277 WQQERARR 284 >5G6V-A nrPDB Length = 324 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 124/297 (41%), Gaps = 41/297 (13%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 M + L LG+GT+ V K K T A+K ++ E A + E +L++ + Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTA--IREVSLLKDLK 58 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYLH 265 H + L T L V EY + +L +L + + + + +++ L Y H Sbjct: 59 HANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 117 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED-N 324 +K V++RDLK +NL++++ G +K+ DFGL + T T Y P++L Sbjct: 118 RQK-VLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGST 176 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-------------------EE 365 DY +D WG+G + YEM GR F E+ I + Sbjct: 177 DYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKT 236 Query: 366 IRFP-----------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 +P L + LL+ LL+ + + R+ A++ M+H FF + Sbjct: 237 YNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-----AEDAMKHPFFLSL 288 >4Y93-A nrPDB Length = 446 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 90/437 (20%), Positives = 164/437 (37%), Gaps = 61/437 (13%) Query: 5 AIVKEGWLHKRGEYIK-----TWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQ 59 ++ E KR + K ++ R FLL Y E + +R + + V + Sbjct: 4 TVILESIFLKRSQQKKKTSPLNFKKRLFLLTVQKL--SYYEYDFERGRRGSKKGSIDVEK 61 Query: 60 CQLMKTERPRPNTFIIRCL----------QWTTVIER---TFHV-----------ETPEE 95 ++T P N R + + ++IER F V T E Sbjct: 62 ITCVETVVPEKNPPPERQIPRRGEESSETEQISIIERFPYPFQVVYDEGPLYVFSPTEEL 121 Query: 96 REEWTTAIQTVA----------------DGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA 139 R+ W ++ V DG + G + + Sbjct: 122 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILAAAPSTAGLGYG 181 Query: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY-YAMKILKKEVIVAKDEVAHTLTE 198 + + +LK LG G FG V K + G+Y A+K++K+ + + + E Sbjct: 182 S--WEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDE----FIEE 233 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEI 257 +V+ N H L L + + EY G L +L R F + ++ Sbjct: 234 AKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV 293 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYL 316 A++YL S K ++RDL N +++ G +K++DFG+ + + D T T P ++ Sbjct: 294 CEAMEYLES-KQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWA 352 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGP 374 +PEVL + + D W GV+M+E+ G++P+ + + E I + P Sbjct: 353 SPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASE 412 Query: 375 EAKSLLSGLLKKDPKQR 391 +++ + +R Sbjct: 413 RVYAIMYSCWHEKADER 429 >1K9A-A nrPDB Length = 450 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 67/270 (24%), Positives = 110/270 (40%), Gaps = 18/270 (6%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + M E + L+ +GKG FG V+L + G A+K +K + L E V+ Sbjct: 190 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQ 242 Query: 205 SRHPFLTALKYSF-QTHDRLCFVMEYANGGELFFHLSRER--VFSEDRARFYGAEIVSAL 261 RH L L + L V EY G L +L V D + ++ A+ Sbjct: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +YL N V+RDL N+++ +D K++DFGL KE T K ++ APE L Sbjct: 303 EYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEAL 358 Query: 322 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSL 379 + + D W G++++E+ GR+P+ + + + ++ P P + Sbjct: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 Query: 380 LSGLLKKDPKQR--LGGGSEDAKEIMQHRF 407 + D R E + I H Sbjct: 419 MKNCWHLDAATRPTFLQLREQLEHIRTHEL 448 >1BYG-A nrPDB Length = 278 Score = 225 bits (573), Expect = 5e-59, Method: Composition-based stats. Identities = 67/270 (24%), Positives = 110/270 (40%), Gaps = 18/270 (6%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 + M E + L+ +GKG FG V+L + G A+K +K + L E V+ Sbjct: 18 LNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA-----QAFLAEASVMTQ 70 Query: 205 SRHPFLTALKYSF-QTHDRLCFVMEYANGGELFFHLSRER--VFSEDRARFYGAEIVSAL 261 RH L L + L V EY G L +L V D + ++ A+ Sbjct: 71 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 130 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321 +YL N V+RDL N+++ +D K++DFGL KE T K ++ APE L Sbjct: 131 EYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEAL 186 Query: 322 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSL 379 + + D W G++++E+ GR+P+ + + + ++ P P + Sbjct: 187 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEV 246 Query: 380 LSGLLKKDPKQRLG--GGSEDAKEIMQHRF 407 + D R E + I H Sbjct: 247 MKNCWHLDAAMRPSFLQLREQLEHIKTHEL 276 >4XI2-A nrPDB Length = 446 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 67/314 (21%), Positives = 124/314 (39%), Gaps = 23/314 (7%) Query: 85 ERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHR 144 E+ PE + LK ++ + G+ E++ Sbjct: 135 EKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGSWEIDP-------- 186 Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRY-YAMKILKKEVIVAKDEVAHTLTENRVLQ 203 + +LK LG G FG V K + G+Y A+K++++ + + + E +V+ Sbjct: 187 ---KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSEDE----FIEEAKVMM 237 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALD 262 N H L L + + EY G L +L R F + ++ A++ Sbjct: 238 NLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME 297 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVL 321 YL S K ++RDL N +++ G +K++DFGL + + D T P + PEVL Sbjct: 298 YLES-KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVL 356 Query: 322 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSL 379 + + D W GV+M+E+ G++P+ + + E I + P ++ Sbjct: 357 MYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTI 416 Query: 380 LSGLLKKDPKQRLG 393 + + +R Sbjct: 417 MYSCWHEKADERPS 430 >3HMP-A nrPDB Length = 342 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 130/327 (39%), Gaps = 34/327 (10%) Query: 101 TAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGT 160 + ++ A K E + MD D+ A K R+ + LK +G G Sbjct: 15 SGMKETAAA--KFERQHMDSPDLGTDDDDKASSSANECISVKGRI----YSILKQIGSGG 68 Query: 161 FGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS--RHPFLTALKYSFQ 218 KV V + + YA+K + E + E L + L Sbjct: 69 SSKVFQVLNEK-KQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEI 126 Query: 219 THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLE 278 T + VME +L L +++ + Y ++ A+ +H + +V+ DLK Sbjct: 127 TDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH-QHGIVHSDLKPA 184 Query: 279 NLMLDKDGHIKITDFGLCKEGIKDGATM--KTFCGTPEYLAPEVLEDNDYGRA------- 329 N ++ DG +K+ DFG+ + D ++ + GT Y+ PE ++D R Sbjct: 185 NFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSK 243 Query: 330 ----VDWWGLGVVMYEMMCGRLPFYNQDHE--KLFELI-LMEEIRFPRTLGPEAKSLLSG 382 D W LG ++Y M G+ PF ++ KL +I EI FP + + +L Sbjct: 244 ISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKC 303 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFA 409 LK+DPKQR+ E++ H + Sbjct: 304 CLKRDPKQRIS-----IPELLAHPYVQ 325 >2UVM-A nrPDB Length = 123 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 123/123 (100%), Positives = 123/123 (100%) Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60 Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120 Query: 121 RSG 123 RSG Sbjct: 121 RSG 123 >4HZS-A nrPDB Length = 341 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 65/254 (25%), Positives = 108/254 (42%), Gaps = 12/254 (4%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKA-TGRYY--AMKILKKEVIVAKDEVAHTLTENRVLQN 204 + L+ LG G+FG V + A +G+ A+K LK +V+ + + + E + + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDY 263 H L L T + V E A G L L + + F Y ++ + Y Sbjct: 72 LDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGY 130 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG--IKDGATMKTFCGTP-EYLAPEV 320 L S++ ++RDL NL+L +KI DFGL + D M+ P + APE Sbjct: 131 LESKR-FIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 189 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRT--LGPEAK 377 L+ + A D W GV ++EM G+ P+ + ++ I E R PR + Sbjct: 190 LKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIY 249 Query: 378 SLLSGLLKKDPKQR 391 +++ P+ R Sbjct: 250 NVMVQCWAHKPEDR 263 >5HI2-A nrPDB Length = 283 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 68/270 (25%), Positives = 119/270 (44%), Gaps = 23/270 (8%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + + + +G G+FG V K A+K+L ++ E VL Sbjct: 15 WEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML------TPQQLQAFKNEVGVL 65 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSAL 261 + +RH + L + T +L V ++ G L+ HL E F + + + Sbjct: 66 RKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGM 124 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPE 319 DYLH+ K++++RDLK N+ L +D +KI DFGL K + G+ ++APE Sbjct: 125 DYLHA-KSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 183 Query: 320 VLE---DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH-EKLFELILMEEIRFP-----R 370 V+ N Y D + G+V+YE+M G+LP+ N ++ +++ E++ + Sbjct: 184 VIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRS 243 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 K L++ LKK +R A+ Sbjct: 244 NCPKRMKRLMAECLKKKRDERPSFPRILAE 273 >4QTB-A nrPDB Length = 380 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 67/326 (20%), Positives = 126/326 (38%), Gaps = 61/326 (18%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 + L+ +G+G +G V + A+K + + TL E ++L RH Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFRHE 99 Query: 209 FLTALKYSFQTHD-----RLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 + ++ + + V + +L+ L ++ S D ++ +I+ L Y Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-LSNDHICYFLYQILRGLKY 157 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT---MKTFCGTPEYLAPEV 320 +HS NV++RDLK NL+++ +KI DFGL + + + + T Y APE+ Sbjct: 158 IHS-ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 216 Query: 321 -LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-------MEEIR----- 367 L Y +++D W +G ++ EM+ R F + + IL E++ Sbjct: 217 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 276 Query: 368 --------------------FPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407 FP++ A LL +L +P +R+ +E + H + Sbjct: 277 KARNYLQSLPSKTKVAWAKLFPKSDSK-ALDLLDRMLTFNPNKRI-----TVEEALAHPY 330 Query: 408 FAGIVWQHVYEKKLSPPFKPQVTSET 433 E+ P +P Sbjct: 331 L---------EQYYDPTDEPVAEEPF 347 >3SXS-A nrPDB Length = 268 Score = 222 bits (565), Expect = 4e-58, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 110/265 (41%), Gaps = 17/265 (6%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRY-YAMKILKKEVIVAKDEVAHTLTENRVL 202 + E LK LG G FG V L K K G+Y A+K++K+ + + E + + Sbjct: 4 ELKREEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSEDE----FFQEAQTM 57 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYGAEIVSAL 261 HP L + V EY + G L +L + + ++ + Sbjct: 58 MKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGM 117 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEV 320 +L S + ++RDL N ++D+D +K++DFG+ + + D P ++ APEV Sbjct: 118 AFLESHQ-FIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV 176 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKS 378 Y D W G++M+E+ G++P+ + ++ + + P Sbjct: 177 FHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQ 236 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIM 403 ++ + P++R ++++ Sbjct: 237 IMYSCWHELPEKR-----PTFQQLL 256 >2ZMD-A nrPDB Length = 390 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 76/327 (23%), Positives = 129/327 (39%), Gaps = 34/327 (10%) Query: 101 TAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGT 160 + ++ A K E + MD D+ A K R+ + LK +G G Sbjct: 15 SGMKETAAA--KFERQHMDSPDLGTDDDDKASSSANECISVKGRI----YSILKQIGSGG 68 Query: 161 FGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS--RHPFLTALKYSFQ 218 KV V + + YA+K + E + E L + L Sbjct: 69 SSKVFQVLNEK-KQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEI 126 Query: 219 THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLE 278 T + VME +L L +++ + Y ++ A+ +H + +V+ DLK Sbjct: 127 TDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH-QHGIVHSDLKPA 184 Query: 279 NLMLDKDGHIKITDFGLCKEGIKDGATM--KTFCGTPEYLAPEVLEDNDYGRA------- 329 N ++ DG +K+ DFG+ + D ++ + G Y+ PE ++D R Sbjct: 185 NFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSK 243 Query: 330 ----VDWWGLGVVMYEMMCGRLPFYNQDHE--KLFELI-LMEEIRFPRTLGPEAKSLLSG 382 D W LG ++Y M G+ PF ++ KL +I EI FP + + +L Sbjct: 244 ISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKC 303 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFA 409 LK+DPKQR+ E++ H + Sbjct: 304 CLKRDPKQRIS-----IPELLAHPYVQ 325 >5O2B-A nrPDB Length = 285 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 129/290 (44%), Gaps = 22/290 (7%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA 188 S EM+ P R + E LG+G F V + T A ++ + Sbjct: 1 SMEAEMKAVATSPSGRFLKFDIE----LGRGAFKTVYKGLDTETWVEVA-WCELQDRKLT 55 Query: 189 KDEVAHTLTENRVLQNSRHPFLTALKYSFQT----HDRLCFVMEYANGGELFFHLSRERV 244 K E E +L+ +HP + S+++ + V E G L +L R +V Sbjct: 56 KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV 115 Query: 245 FSEDRARFYGAEIVSALDYLHSE-KNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKD 302 R + +I+ L +LH+ +++RDLK +N+ + G +KI D GL + Sbjct: 116 MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT--LMR 173 Query: 303 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN-QDHEKLFELI 361 + K+ GTPE++APE+ E+ Y +VD + G+ M EM P+ Q+ +++ + Sbjct: 174 TSFAKSVIGTPEFMAPEMYEE-HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 232 Query: 362 LME--EIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 F + PE K ++ G ++++ +RL ++++ H FFA Sbjct: 233 TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLS-----IRDLLNHAFFA 277 >3ZBF-A nrPDB Length = 322 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 115/295 (38%), Gaps = 30/295 (10%) Query: 119 DFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK-----EKATG 173 D+ + + +E A P+ ++T+ L LG G FG+V +G Sbjct: 9 DYGIPTTENLYFQGSIENLPAFPREKLTL---RLL--LGSGAFGEVYEGTAVDILGVGSG 63 Query: 174 RY-YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANG 232 A+K LKK E L E ++ HP + ++ ++E G Sbjct: 64 EIKVAVKTLKKG--STDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEG 121 Query: 233 GELFFHLSRERVFS-------EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML--- 282 G+L +L + R+ + +I YL + ++RDL N ++ Sbjct: 122 GDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL-ERMHFIHRDLAARNCLVSVK 180 Query: 283 --DKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVV 338 +KI DFGL ++ K+ K G ++APE L D + D W G++ Sbjct: 181 DYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGIL 240 Query: 339 MYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 ++E++ G P+ + + + + PR + +L++ ++P QR Sbjct: 241 IWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQR 295 >1U54-B nrPDB Length = 291 Score = 221 bits (564), Expect = 5e-58, Method: Composition-based stats. Identities = 65/254 (25%), Positives = 108/254 (42%), Gaps = 12/254 (4%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKA-TGRYY--AMKILKKEVIVAKDEVAHTLTENRVLQN 204 + L+ LG G+FG V + A +G+ A+K LK +V+ + + + E + + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDY 263 H L L T + V E A G L L + + F Y ++ + Y Sbjct: 78 LDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGY 136 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG--IKDGATMKTFCGTP-EYLAPEV 320 L S++ ++RDL NL+L +KI DFGL + D M+ P + APE Sbjct: 137 LESKR-FIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 195 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRT--LGPEAK 377 L+ + A D W GV ++EM G+ P+ + ++ I E R PR + Sbjct: 196 LKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIY 255 Query: 378 SLLSGLLKKDPKQR 391 +++ P+ R Sbjct: 256 NVMVQCWAHKPEDR 269 >3I81-A nrPDB Length = 315 Score = 221 bits (563), Expect = 5e-58, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 115/302 (38%), Gaps = 25/302 (8%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY-----YAMKILKKEVIVAKDEVAHTL 196 + V + + LG+G+FG V K + A+K + + + E L Sbjct: 12 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASM--RERIEFL 69 Query: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER----------VFS 246 E V++ + L +ME G+L +L R S Sbjct: 70 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS 129 Query: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306 + EI + YL++ K V+RDL N M+ +D +KI DFG+ ++ + Sbjct: 130 LSKMIQMAGEIADGMAYLNANK-FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 188 Query: 307 KTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM 363 K G +++PE L+D + D W GVV++E+ P+ +E++ ++ Sbjct: 189 KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVME 248 Query: 364 EE-IRFPRTLGPEAKSLLSGLLKKDPKQRLGGGS--EDAKEIMQHRFFAGIVWQHVYEKK 420 + P L+ + +PK R KE M+ F + + + E K Sbjct: 249 GGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME-PGFREVSFYYSEENK 307 Query: 421 LS 422 + Sbjct: 308 ME 309 >3MIA-A nrPDB Length = 351 Score = 221 bits (563), Expect = 5e-58, Method: Composition-based stats. Identities = 76/324 (23%), Positives = 130/324 (40%), Gaps = 62/324 (19%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 ++++E L +G+GTFG+V + + TG+ A+K + E + L E ++LQ + Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLK 74 Query: 207 HPFLTALKYSFQTH--------DRLCFVMEYANG---GELFFHLSRERVFSEDRARFYGA 255 H + L +T + V ++ G L L + F+ + Sbjct: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQ 131 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG----IKDGATMKTFCG 311 +++ L Y+H K +++RD+K N+++ +DG +K+ DFGL + Sbjct: 132 MLLNGLYYIHRNK-ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Query: 312 TPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRL----------------------P 348 T Y PE+L DYG +D WG G +M EM P Sbjct: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 Query: 349 --FYNQDHEKLFELI-------LMEEIRFPRTL-GPEAKSLLSGLLKKDPKQRLGGGSED 398 + N D+ +L+E + + R + P A L+ LL DP QR+ D Sbjct: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----D 305 Query: 399 AKEIMQHRFFAGIVWQHVYEKKLS 422 + + + H FF W L Sbjct: 306 SDDALNHDFF----WSDPMPSDLK 325 >3OMV-A nrPDB Length = 307 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 79/304 (25%), Positives = 133/304 (43%), Gaps = 30/304 (9%) Query: 115 EEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR 174 +E+ R D+S E+E S R +G G+FG V K Sbjct: 14 QEKNKIRPRGQRDSSYYWEIEASEVMLSTR-----------IGSGSFGTVYKGKWHGD-- 60 Query: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGE 234 A+KILK V ++ E VL+ +RH + L + T D L V ++ G Sbjct: 61 -VAVKILKV-VDPTPEQFQAFRNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSS 117 Query: 235 LFFHLS-RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF 293 L+ HL +E F + + +DYLH+ KN+++RD+K N+ L + +KI DF Sbjct: 118 LYKHLHVQETKFQMFQLIDIARQTAQGMDYLHA-KNIIHRDMKSNNIFLHEGLTVKIGDF 176 Query: 294 GLC--KEGIKDGATMKTFCGTPEYLAPEVLE---DNDYGRAVDWWGLGVVMYEMMCGRLP 348 GL K ++ G+ ++APEV+ +N + D + G+V+YE+M G LP Sbjct: 177 GLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELP 236 Query: 349 FYNQDHEKLFELILMEEIRFPR------TLGPEAKSLLSGLLKKDPKQR-LGGGSEDAKE 401 + + ++ ++ P K L++ +KK ++R L + E Sbjct: 237 YSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 296 Query: 402 IMQH 405 ++QH Sbjct: 297 LLQH 300 >3ORP-A nrPDB Length = 311 Score = 220 bits (562), Expect = 8e-58, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 124/304 (40%), Gaps = 27/304 (8%) Query: 137 SLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 196 + P H + +E ++LG G +V L ++ R A+K+L+ ++ Sbjct: 3 HMTTPSH--LSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFR 60 Query: 197 TENRVLQNSRHPFLTALKYSFQTHDRL----CFVMEYANGGELFFHLSRERVFSEDRARF 252 E + HP + A+ + + VMEY +G L + E + RA Sbjct: 61 REAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIE 120 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT---F 309 A+ AL++ H + +++RD+K N+M+ +K+ DFG+ + G ++ Sbjct: 121 VIADACQALNFSH-QNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAV 179 Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369 GT +YL+PE + D + LG V+YE++ G PF + + E+ P Sbjct: 180 IGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPP 239 Query: 370 ----RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPF 425 L + +++ L K+P+ R + A E+ V PP Sbjct: 240 SARHEGLSADLDAVVLKALAKNPENRY----QTAAEMRA---------DLVRVHNGEPPE 286 Query: 426 KPQV 429 P+V Sbjct: 287 APKV 290 >4OLI-A nrPDB Length = 645 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 72/289 (24%), Positives = 113/289 (39%), Gaps = 32/289 (11%) Query: 131 AEEMEVSLAKPKHRVTMNEFEYLKLL---GKGTFGKVILV----KEKATGRYYAMKILKK 183 A+ + V+ P T+ YLK + G+G FGKV L TG A+K LK Sbjct: 333 ADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKA 392 Query: 184 EVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR--LCFVMEYANGGELFFHLSR 241 + + E +L+ H + K + L VMEY G L +L R Sbjct: 393 DC--GPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPR 450 Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 + + +I + YLHS+ + ++R+L N++LD D +KI DFGL K + Sbjct: 451 H-SIGLAQLLLFAQQICEGMAYLHSQ-HYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPE 508 Query: 302 DGATMKTFC---GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG-----RLP--FY- 350 + + APE L++ + A D W GV +YE++ P F Sbjct: 509 GHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLE 568 Query: 351 -------NQDHEKLFELILMEE-IRFPRTLGPEAKSLLSGLLKKDPKQR 391 +L EL+ E + P E L+ + + R Sbjct: 569 LIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFR 617 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 67/314 (21%), Positives = 108/314 (34%), Gaps = 50/314 (15%) Query: 116 EEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATG-- 173 E + G+ + ++S HRV E L LG+GT V + + G Sbjct: 17 TENLYFQGARASPRTLNLSQLSF----HRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSG 72 Query: 174 ----------------------RYYAMKILKKEVIVAKDEVAHTLTE-NRVLQNSRHPFL 210 +K+L + ++A E ++ H L Sbjct: 73 DPEEGKMDDEDPLVPGRDRGQELRVVLKVLDP----SHHDIALAFYETASLMSQVSHTHL 128 Query: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLHSEKN 269 + V EY G L L RER ++ SAL YL KN Sbjct: 129 AFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYL-ENKN 187 Query: 270 VVYRDLKLENLML-------DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 +V+ ++ N++L IK++D G+ + ++ +LAPE L Sbjct: 188 LVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERI----PWLAPECLP 243 Query: 323 D--NDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379 N A+D WG G + E+ G P ++ + E + R P P+ +L Sbjct: 244 GGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATL 302 Query: 380 LSGLLKKDPKQRLG 393 S L +P QR Sbjct: 303 TSQCLTYEPTQRPS 316 >1AD5-A nrPDB Length = 438 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 105/255 (41%), Gaps = 22/255 (8%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILV-KEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 + + K LG G FG+V + K T A+K +K + V L E Sbjct: 176 AWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMS----VEAFLAEAN 229 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF--SEDRARFYGAEIV 258 V++ +H L L T + + + E+ G L L + + + A+I Sbjct: 230 VMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIA 288 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318 + ++ ++N ++RDL+ N+++ KI DFGL + G K ++ AP Sbjct: 289 EGMAFI-EQRNYIHRDLRAANILVSASLVCKIADFGLARVGAKFP---------IKWTAP 338 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEA 376 E + + D W G+++ E++ GR+P+ + ++ + + P E Sbjct: 339 EAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEEL 398 Query: 377 KSLLSGLLKKDPKQR 391 +++ K P++R Sbjct: 399 YNIMMRCWKNRPEER 413 >6DBM-A nrPDB Length = 318 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 111/287 (38%), Gaps = 31/287 (10%) Query: 132 EEMEVSLAKPKHRVTMNE--FEYLKLLGKGTFGKVILV----KEKATGRYYAMKILKKEV 185 +EV P ++ + ++ LG+G FGKV L TG A+K LK + Sbjct: 13 GALEVLFQGPGDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADA 72 Query: 186 IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHD--RLCFVMEYANGGELFFHLSRER 243 + E +L+ H + K + L VMEY G L +L R Sbjct: 73 --GPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRH- 129 Query: 244 VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG 303 + + +I + YLHS+ + ++RDL N++LD D +KI DFGL K + Sbjct: 130 SIGLAQLLLFAQQICEGMAYLHSQ-HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGH 188 Query: 304 ATMKTFC---GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG-----RLP--FY--- 350 + + APE L++ + A D W GV +YE++ P F Sbjct: 189 EYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELI 248 Query: 351 -----NQDHEKLFELILMEE-IRFPRTLGPEAKSLLSGLLKKDPKQR 391 +L EL+ E + P E L+ + + R Sbjct: 249 GIAQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFR 295 >2WTK-C nrPDB Length = 305 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 83/295 (28%), Positives = 135/295 (45%), Gaps = 18/295 (6%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA-KDEVAHTLTENRVLQNS 205 + ++ LLG+G++GKV V + T A+KILKK+ + + A+ E ++L+ Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 206 RHPFLTALKYSF--QTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSAL 261 RH + L + ++ VMEY G E+ + +R F +A Y +++ L Sbjct: 64 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKR-FPVCQAHGYFCQLIDGL 122 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD--GATMKTFCGTPEYLAPE 319 +YLHS+ +V++D+K NL+L G +KI+ G+ + T +T G+P + PE Sbjct: 123 EYLHSQ-GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPE 181 Query: 320 VLED--NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAK 377 + G VD W GV +Y + G PF + KLFE I P GP Sbjct: 182 IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLS 241 Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSE 432 LL G+L+ +P +R ++I QH +F E + P P Sbjct: 242 DLLKGMLEYEPAKRFS-----IRQIRQHSWFRKK--HPPAEAPVPIPPSPDTKDR 289 >5B2L-A nrPDB Length = 324 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 74/321 (23%), Positives = 136/321 (42%), Gaps = 26/321 (8%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 +++ +++ +N+ E L +G GT G+V ++ + TG A+K +++ K+E Sbjct: 5 LTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSG--NKEENKRI 62 Query: 196 LTENRV-LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYG 254 L + V L++ P++ +F T+ + ME + E Sbjct: 63 LMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMT 122 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE 314 IV AL YL + V++RD+K N++LD+ G IK+ DFG+ + A ++ G Sbjct: 123 VAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAA 181 Query: 315 YLAPEVLE-----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-KLFELILMEEIRF 368 Y+APE ++ DY D W LG+ + E+ G+ P+ N + ++ +L EE Sbjct: 182 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPL 241 Query: 369 PR---TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI--------VWQHVY 417 + +S + L KD ++R ++++H F W Sbjct: 242 LPGHMGFSGDFQSFVKDCLTKDHRKR-----PKYNKLLEHSFIKRYETLEVDVASWFKDV 296 Query: 418 EKKLSPPFKPQVTSETDTRYF 438 K P V S+ +F Sbjct: 297 MAKTESPRTSGVLSQPHLPFF 317 >5ZTN-A nrPDB Length = 429 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 81/385 (21%), Positives = 151/385 (39%), Gaps = 95/385 (24%) Query: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168 GL ++ + M +G P +N G ++ + S + H +E LK++GKG+FG+V+ Sbjct: 62 GLNAKKRQGM---TGGP-NNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY 117 Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP------FLTALKYSFQTHDR 222 + ++ A+K+++ E K E R+L++ R + + +F + Sbjct: 118 DHKVHQHVALKMVRNE----KRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNH 173 Query: 223 LCFVMEYANGGELFFHLSRER--VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENL 280 +C E + L+ + + + FS R + I+ LD LH + +++ DLK EN+ Sbjct: 174 ICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNR-IIHCDLKPENI 231 Query: 281 MLDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVV 338 +L + G IK+ DFG + + T+ + Y APEV+ YG +D W LG + Sbjct: 232 LLKQQGRSGIKVIDFGSS---CYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCI 288 Query: 339 MYEMMCGRLPFYNQDHEK----LFELILMEEIR----------------FPRTL------ 372 + E++ G +D + EL+ M + +PR Sbjct: 289 LAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLS 348 Query: 373 ------------------GPEAK---------------SLLSGLLKKDPKQRLGGGSEDA 399 PE++ L L+ DP R+ G Sbjct: 349 DGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPG---- 404 Query: 400 KEIMQHRFFAGIVWQHVYEKKLSPP 424 + ++H + + + PP Sbjct: 405 -QALRHPW--------LRRRLPKPP 420 >3RP9-A nrPDB Length = 458 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 83/470 (17%), Positives = 150/470 (31%), Gaps = 130/470 (27%) Query: 97 EEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTM-NEFEYLKL 155 ++ + Q G +++ ++ S P+ S+ +P + + +E L Sbjct: 10 QQHNSGTQHTVSGSQQEGQQRKQHHSSKPT---------ASMPRPHSDWQIPDRYEIRHL 60 Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 +G G++G V +K R A+K + + V + L E +L H + + Sbjct: 61 IGTGSYGHVCEAYDKLEKRVVAIKKILR-VFEDLIDCKRILREIAILNRLNHDHVVKVLD 119 Query: 216 SFQTHD-----RLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLHSEKN 269 D L V+E A+ F L R V +E + ++ + Y+HS Sbjct: 120 IVIPKDVEKFDELYVVLEIAD--SDFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHS-AG 176 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA------------------------- 304 +++RDLK N ++++D +K+ DFGL + Sbjct: 177 ILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNL 236 Query: 305 --TMKTFCGTPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEMMC-----------GRLPFY 350 + T Y APE +L +Y A+D W +G + E++ F Sbjct: 237 KRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFP 296 Query: 351 N-----------------------QDHEKLFELILMEEIR-----------------FP- 369 +D + IL FP Sbjct: 297 GSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPK 356 Query: 370 ----------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY-- 417 +A LL +L +P +R+ E + H FF + V Sbjct: 357 REGTDLAERFPASSADAIHLLKRMLVFNPNKRI-----TINECLAHPFFKEVRIAEVETN 411 Query: 418 -EKKLSPPF-------KPQVTSETDTRYFDEEFTAQMITITPPDQDDSME 459 +K+ PF +PQ+ F +E I P + + Sbjct: 412 ATEKVRLPFNDWMNMDEPQLRYA-----FVKEIQRYHPEIQLPRRSPNRA 456 >1S9I-A nrPDB Length = 354 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 123/317 (38%), Gaps = 57/317 (17%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + LG G G V V+ + +G A K++ E+ A + E +VL Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIR--NQIIRELQVLHECNS 73 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P++ +F + + ME+ +GG L L + E+ ++ L YL + Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK 133 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +++RD+K N++++ G IK+ DFG+ + I + +F GT Y+APE L+ Y Sbjct: 134 HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSFVGTRSYMAPERLQGTHYS 191 Query: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE---------------------------- 359 D W +G+ + E+ GR P D ++L Sbjct: 192 VQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPV 251 Query: 360 -------------------LILMEEIRFPR-TLGPEAKSLLSGLLKKDPKQRLGGGSEDA 399 ++ + P P+ + ++ L K+P +R D Sbjct: 252 SGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAER-----ADL 306 Query: 400 KEIMQHRFFAGIVWQHV 416 K + H F + V Sbjct: 307 KMLTNHTFIKRSEVEEV 323 >1TKI-A nrPDB Length = 321 Score = 217 bits (554), Expect = 7e-57, Method: Composition-based stats. Identities = 70/269 (26%), Positives = 127/269 (47%), Gaps = 18/269 (6%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++ + LG+G FG V E ++ + Y K +K + + E +L +RH Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT----DQVLVKKEISILNIARH 60 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLHS 266 + L SF++ + L + E+ +G ++F ++ +E Y ++ AL +LHS Sbjct: 61 RNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHS 120 Query: 267 EKNVVYRDLKLENLMLD--KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324 N+ + D++ EN++ + IKI +FG ++ +K G + PEY APEV + + Sbjct: 121 H-NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQ-LKPGDNFRLLFTAPEYYAPEVHQHD 178 Query: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR----TLGPEAKSLL 380 A D W LG ++Y ++ G PF + ++++ E I+ E F + EA + Sbjct: 179 VVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFV 238 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 LL K+ K R+ A E +QH + Sbjct: 239 DRLLVKERKSRM-----TASEALQHPWLK 262 >5O2C-A nrPDB Length = 380 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 69/281 (24%), Positives = 125/281 (44%), Gaps = 22/281 (7%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 P R + E LG+G F V + T A ++ + K E Sbjct: 19 ATSPSGRFLKFDIE----LGRGAFKTVYKGLDTETWVEVA-WCELQDRKLTKAEQQRFKE 73 Query: 198 ENRVLQNSRHPFLTALKYSFQT----HDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253 E +L+ +HP + S+++ + V E G L +L R +V R + Sbjct: 74 EAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSW 133 Query: 254 GAEIVSALDYLHSE-KNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCG 311 +I+ L +LH+ +++RDLK +N+ + G +KI D GL + + K+ G Sbjct: 134 CRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLAT--LMRTSFAKSVIG 191 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN-QDHEKLFELILME--EIRF 368 TPE++APE+ E+ Y +VD + G+ M EM P+ Q+ +++ + F Sbjct: 192 TPEFMAPEMYEE-HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASF 250 Query: 369 PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + PE K ++ G ++++ +RL ++++ H FFA Sbjct: 251 NKVTDPEVKEIIEGCIRQNKSERLS-----IRDLLNHAFFA 286 >2BRG-A nrPDB Length = 297 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 65/269 (24%), Positives = 131/269 (48%), Gaps = 14/269 (5%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + +++ ++ LG+G +G+V L + T A+KI+ ++ A D + E + + Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIV--DMKRAVDCPENIKKEICINKMLN 63 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 H + + + +EY +GGELF + + E A+ + ++++ + YLH Sbjct: 64 HENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT--MKTFCGTPEYLAPEVLEDN 324 + +RD+K ENL+LD+ ++KI+DFGL + + CGT Y+APE+L+ Sbjct: 124 -IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 325 DY-GRAVDWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEEIRFP-RTLGPEAKSLL 380 ++ VD W G+V+ M+ G LP+ + ++ + + P + + +LL Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALL 242 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 +L ++P R+ +I + R++ Sbjct: 243 HKILVENPSARI-----TIPDIKKDRWYN 266 >4PWN-A nrPDB Length = 274 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 65/264 (24%), Positives = 120/264 (45%), Gaps = 17/264 (6%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +G+G+F V + T A ++ + K E E +L+ +HP + Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVA-WCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFY 75 Query: 215 YSFQT----HDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE-KN 269 S+++ + V E G L +L R +V R + +I+ L +LH+ Sbjct: 76 DSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 270 VVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 +++RDLK +N+ + G +KI D GL K + K+ GTPE++APE+ E+ Y Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLA-TLEKRASFAKSVIGTPEFMAPEMYEE-KYDE 193 Query: 329 AVDWWGLGVVMYEMMCGRLPFYN-QDHEKLFELILME--EIRFPRTLGPEAKSLLSGLLK 385 +VD + G+ M EM P+ Q+ +++ + F + PE K ++ G ++ Sbjct: 194 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIR 253 Query: 386 KDPKQRLGGGSEDAKEIMQHRFFA 409 ++ +R K+++ H FF Sbjct: 254 QNKDERYS-----IKDLLNHAFFQ 272 >5U6B-A nrPDB Length = 307 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 108/260 (41%), Gaps = 20/260 (7%) Query: 152 YLKLLGKGTFGKVILVKEKATG--RYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 K LG+G FG V+ + A+K +K I + E+ L+E ++ HP Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKI-AICTRSELEDFLSEAVCMKEFDHPN 85 Query: 210 LTALKYSF------QTHDRLCFVMEYANGGELFFHLSRER------VFSEDRARFYGAEI 257 + L ++ ++ + G+L L R + A+I Sbjct: 86 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEY 315 S ++YL S K ++RDL N ML+++ + + DFGL K+ + ++ Sbjct: 146 ASGMEYL-STKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKW 204 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLG 373 +A E L D Y D W GV M+E+ G+ P+ ++ ++++ + ++ P Sbjct: 205 IAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCL 264 Query: 374 PEAKSLLSGLLKKDPKQRLG 393 +L+S + +P+ R Sbjct: 265 DGLYALMSRCWELNPQDRPS 284 >6FER-A nrPDB Length = 309 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 109/289 (37%), Gaps = 41/289 (14%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGR----------------YYAMKILKKEVI 186 + + LG+G FG+V L + + + A+K+L+ + Sbjct: 4 EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA- 62 Query: 187 VAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE---- 242 K+ L E +++ + P + L T D LC + EY G+L LSR Sbjct: 63 -NKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN 121 Query: 243 ------RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC 296 R S +F +I S + YL S N V+RDL N ++ K+ IKI DFG+ Sbjct: 122 SSSSDVRTVSYTNLKFMATQIASGMKYL-SSLNFVHRDLATRNCLVGKNYTIKIADFGMS 180 Query: 297 KEGIK-DGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYE--MMCGRLPFYNQ 352 + D ++ P +++ E + + A D W GV ++E C P+ Sbjct: 181 RNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQL 240 Query: 353 DHEKLFELI--------LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 E++ E + P L+ ++D K R Sbjct: 241 SDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPS 289 >5HIE-A nrPDB Length = 302 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 67/261 (25%), Positives = 113/261 (43%), Gaps = 23/261 (8%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + + + +G G+FG V K A+K+L ++ E VL Sbjct: 31 WEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML------TPQQLQAFKNEVGVL 81 Query: 203 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSAL 261 + +RH + L + T +L V ++ G L+ HL E F + + + Sbjct: 82 RKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGM 140 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC--KEGIKDGATMKTFCGTPEYLAPE 319 DYLH+ K++++RDLK N+ L +D +KI DFGL K + G+ ++APE Sbjct: 141 DYLHA-KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 199 Query: 320 VLE---DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR------ 370 V+ N Y D + G+V+YE+M G+LP+ N ++ ++ P Sbjct: 200 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 259 Query: 371 TLGPEAKSLLSGLLKKDPKQR 391 K L++ LKK +R Sbjct: 260 NCPKAMKRLMAECLKKKRDER 280 >2W1I-A nrPDB Length = 326 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 124/305 (40%), Gaps = 39/305 (12%) Query: 116 EEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK----EKA 171 E + G+ S E+ + + + +H ++L+ LGKG FG V + + + Sbjct: 17 TENLYFQGA--MGSAFEDRDPTQFEERH------LKFLQQLGKGNFGSVEMCRYDPLQDN 68 Query: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR--LCFVMEY 229 TG A+K L+ ++ + E +L++ +H + K + R L +MEY Sbjct: 69 TGEVVAVKKLQHS---TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEY 125 Query: 230 ANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI 288 G L +L + + + Y ++I ++YL K ++RDL N++++ + + Sbjct: 126 LPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYL-GTKRYIHRDLATRNILVENENRV 184 Query: 289 KITDFGLCKEGIKDGATMKTFC---GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC- 344 KI DFGL K +D K + APE L ++ + A D W GVV+YE+ Sbjct: 185 KIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTY 244 Query: 345 ----GRLP--F------YNQDHEKLFELIL----MEEIRFPRTLGPEAKSLLSGLLKKDP 388 P F Q +F LI + P E +++ + Sbjct: 245 IEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNV 304 Query: 389 KQRLG 393 QR Sbjct: 305 NQRPS 309 >3DLS-A nrPDB Length = 335 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 79/283 (27%), Positives = 130/283 (45%), Gaps = 26/283 (9%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVI-----VAKDEVAHTLTENRVLQ 203 ++ + LG G FG V +K + +K +KKE + + ++ E +L Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSALD 262 H + + F+ VME G +LF + R E A + ++VSA+ Sbjct: 85 RVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVG 144 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322 YL K++++RD+K EN+++ +D IK+ DFG ++ G TFCGT EY APEVL Sbjct: 145 YL-RLKDIIHRDIKDENIVIAEDFTIKLIDFGSA-AYLERGKLFYTFCGTIEYCAPEVLM 202 Query: 323 DNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381 N Y G ++ W LGV +Y ++ PF E + I P + E SL+S Sbjct: 203 GNPYRGPELEMWSLGVTLYTLVFEENPFCE------LEETVEAAIHPPYLVSKELMSLVS 256 Query: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFF------AGIVWQHVYE 418 GLL+ P++R ++++ + A W+ V+ Sbjct: 257 GLLQPVPERR-----TTLEKLVTDPWVTQPVNLADYTWEEVFR 294 >3IO7-A nrPDB Length = 313 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 117/285 (41%), Gaps = 36/285 (12%) Query: 141 PKHRVTMNEFE-----YLKLLGKGTFGKVILVK----EKATGRYYAMKILKKEVIVAKDE 191 P+ M +FE +L+ LGKG FG V + + + TG A+K L+ ++ Sbjct: 16 PRGSHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS---TEEH 72 Query: 192 VAHTLTENRVLQNSRHPFLTALKYSFQTHDR--LCFVMEYANGGELFFHLSRER-VFSED 248 + E +L++ +H + K + R L +MEY G L +L + + Sbjct: 73 LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI 132 Query: 249 RARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT 308 + Y ++I ++YL K ++RDL N++++ + +KI DFGL K +D K Sbjct: 133 KLLQYTSQICKGMEYL-GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV 191 Query: 309 FC---GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-----GRLP--F------YNQ 352 + APE L ++ + A D W GVV+YE+ P F Q Sbjct: 192 KEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQ 251 Query: 353 DHEKLFELIL----MEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 +F LI + P E +++ + QR Sbjct: 252 GQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPS 296 >3BBT-B nrPDB Length = 328 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 64/312 (20%), Positives = 118/312 (37%), Gaps = 24/312 (7%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYY----AMKILKKEVIVAKDEVAHTLTENRVLQ 203 E + +K+LG G FG V G A+KIL + + + E ++ Sbjct: 15 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKAN--VEFMDEALIMA 72 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALD 262 + HP L L + + V + G L ++ + + +I + Sbjct: 73 SMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMM 131 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEV 320 YL E+ +V+RDL N+++ H+KITDFGL + D G +++A E Sbjct: 132 YL-EERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALEC 190 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPEAKS 378 + + D W GV ++E+M G P+ ++ +L+ E + P + Sbjct: 191 IHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYM 250 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438 ++ D R A+ F+ + + + ++ S D+++F Sbjct: 251 VMVKCWMIDADSRPKFKELAAE-------FSRMARDPQRYLVIQGDDRMKLPSPNDSKFF 303 Query: 439 ----DEEFTAQM 446 DEE M Sbjct: 304 QNLLDEEDLEDM 315 >2W96-B nrPDB Length = 306 Score = 214 bits (546), Expect = 6e-56, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 119/298 (39%), Gaps = 46/298 (15%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR- 206 + +E + +G G +G V ++ +G + A+K ++ ++ T+ E +L+ Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPIS-TVREVALLRRLEA 62 Query: 207 --HPFLTALKYSFQTHD-----RLCFVMEYANGGELFFHLSRERV--FSEDRARFYGAEI 257 HP + L T ++ V E+ + +L +L + + + + Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 + LD+LH+ +V+RDLK EN+++ G +K+ DFGL + + T Y A Sbjct: 122 LRGLDFLHANC-IVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQMALDPVVVTLWYRA 179 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI-----LMEEIRFPRTL 372 PEVL + Y VD W +G + EM + F I L E +PR + Sbjct: 180 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 239 Query: 373 G------------------PEAKS----LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 PE + LL +L +P +R+ A +QH + Sbjct: 240 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL 292 >5Y86-A nrPDB Length = 588 Score = 214 bits (544), Expect = 9e-56, Method: Composition-based stats. Identities = 73/366 (19%), Positives = 134/366 (36%), Gaps = 83/366 (22%) Query: 116 EEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY 175 + +N G ++ + + +E LK++GKG+FG+V V + +Y Sbjct: 175 AKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQY 234 Query: 176 YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP------FLTALKYSFQTHDRLCFVMEY 229 A+K+++ E K E R+L++ + + + SF + +C E Sbjct: 235 VALKMVRNE----KRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL 290 Query: 230 ANGGELFFHLSRER--VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287 + +L+ + + + FS R + I+ +LD LH K +++ DLK EN++L G Sbjct: 291 LS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK-IIHCDLKPENILLKHHGR 348 Query: 288 --IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 345 K+ DFG + + T+ + Y APE++ + Y +D W G ++ E++ G Sbjct: 349 SSTKVIDFGSS---CFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTG 405 Query: 346 RLPFYNQD---------------HEKLFELILMEEI-----RFPRTLG------------ 373 + F +D KL E + PR Sbjct: 406 QPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLV 465 Query: 374 ------------PEAKS---------------LLSGLLKKDPKQRLGGGSEDAKEIMQHR 406 P +K L L DP RL + ++H Sbjct: 466 GGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARL-----TPAQALRHP 520 Query: 407 FFAGIV 412 + + V Sbjct: 521 WISKSV 526 >4YFF-A nrPDB Length = 311 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 113/259 (43%), Gaps = 10/259 (3%) Query: 141 PKH-RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199 P H + ++E E+ +++G G+FGKV + + + A+K + +K +V E Sbjct: 34 PSHFHLQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREV 91 Query: 200 RVLQNSRHPFLTALKYSFQTHD-RLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEI 257 +L HP + + + V +Y +GG LF L ++R+ ++ Sbjct: 92 SILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDV 151 Query: 258 VSALDYLHS-EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK-DGATMKTFCGTPEY 315 ++YLH+ + +++RDL N++L +DGH + DFG + D M G + Sbjct: 152 AKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRW 211 Query: 316 LAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP--RTL 372 +APEV Y D + + ++E++ G +PF + + IR P ++ Sbjct: 212 MAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSI 271 Query: 373 GPEAKSLLSGLLKKDPKQR 391 SLL P+ R Sbjct: 272 PKPISSLLIRGWNACPEGR 290 >5U6C-A nrPDB Length = 315 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 118/287 (41%), Gaps = 22/287 (7%) Query: 123 GSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILV---KEKATGRYYAMK 179 G G+EE++ L + N K+LG+G FG V+ +E T A+K Sbjct: 13 GENLYFQGSEELQNKLEDVV--IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVK 70 Query: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTH-----DRLCFVMEYANGGE 234 +K + ++ E+ L+E +++ HP + L + ++ + G+ Sbjct: 71 TMKLDN-SSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGD 129 Query: 235 LFFHL------SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI 288 L +L + + + +I ++YL S +N ++RDL N ML D + Sbjct: 130 LHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYL-SNRNFLHRDLAARNCMLRDDMTV 188 Query: 289 KITDFGLCKEGIKDGATMKTFCG--TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-G 345 + DFGL K+ + +++A E L D Y D W GV M+E+ G Sbjct: 189 CVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRG 248 Query: 346 RLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLLSGLLKKDPKQR 391 P+ + ++++ +L ++ P E ++ + DP R Sbjct: 249 MTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDR 295 >4E20-A nrPDB Length = 290 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 105/271 (38%), Gaps = 37/271 (13%) Query: 150 FEYLKLLGKGTFGKVILV----KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + ++ LG+G FGKV L TG A+K LK+ + E +L+ Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGC--GPQLRSGWQREIEILRTL 67 Query: 206 RHPFLTALKYSFQTHDR--LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 H + K + + VMEY G L +L R + + +I + Y Sbjct: 68 YHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRH-CVGLAQLLLFAQQICEGMAY 126 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC---GTPEYLAPEV 320 LH++ + ++R L N++LD D +KI DFGL K + + + APE Sbjct: 127 LHAQ-HYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPEC 185 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD---HEKLFELI---------------- 361 L++ + A D W GV +YE++ + + + H K ELI Sbjct: 186 LKECKFYYASDVWSFGVTLYELLT----YCDSNQSPHTKFTELIGHTQGQMTVLRLTELL 241 Query: 362 -LMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 E + P E L+ + + R Sbjct: 242 ERGERLPRPDRCPCEIYHLMKNCWETEASFR 272 >5AIR-A nrPDB Length = 430 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 70/299 (23%), Positives = 123/299 (41%), Gaps = 54/299 (18%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 + K++G G+FG V K +G A+K + ++ E ++++ H Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------RELQIMRKLDHCN 118 Query: 210 LTALKYSFQTHD------RLCFVMEYAN---GGELFFHLSRERVFSEDRARFYGAEIVSA 260 + L+Y F + L V++Y + ++ + Y ++ + Sbjct: 119 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 178 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKD-GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 L Y+HS + +RD+K +NL+LD D +K+ DFG K+ ++ + C + Y APE Sbjct: 179 LAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC-SRYYRAPE 236 Query: 320 VLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH-EKLFELILM-------------- 363 ++ DY ++D W G V+ E++ G+ F ++L E+I + Sbjct: 237 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 296 Query: 364 --EEIRFP------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 E +FP PEA +L S LL+ P RL E H FF Sbjct: 297 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL-----EACAHSFF 350 >6DBN-A nrPDB Length = 316 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 72/291 (24%), Positives = 118/291 (40%), Gaps = 42/291 (14%) Query: 136 VSLAKPKHRVTMNEFEY-----LKLLGKGTFGKVILVK----EKATGRYYAMKILKKEVI 186 VS KP V FE ++ LG+G FGKV L + TG A+K LK E Sbjct: 18 VSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPE-- 75 Query: 187 VAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR--LCFVMEYANGGELFFHLSRER- 243 + +A E +L+N H + K + +ME+ G L +L + + Sbjct: 76 SGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKN 135 Query: 244 VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGL--CKEGIK 301 + + Y +I +DYL S + V+RDL N++++ + +KI DFGL E K Sbjct: 136 KINLKQQLKYAVQICKGMDYLGSRQ-YVHRDLAARNVLVESEHQVKIGDFGLTKAIETDK 194 Query: 302 DGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360 + T+K +P + APE L + + A D W GV ++E++ + + D + Sbjct: 195 EYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT----YCDSDSSPMALF 250 Query: 361 ILM--------------------EEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 + M + + P E L+ + P R Sbjct: 251 LKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNR 301 >6GVJ-A nrPDB Length = 429 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 125/315 (39%), Gaps = 32/315 (10%) Query: 113 QEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKAT 172 Q+++ + + A K R+ + LK +G G KV V + Sbjct: 113 QQQQHQILATPLQNLQVLASSSANECISVKGRI----YSILKQIGSGGSSKVFQVLNEK- 167 Query: 173 GRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS--RHPFLTALKYSFQTHDRLCFVMEYA 230 + YA+K + E + E L + L T + VME Sbjct: 168 KQIYAIKYVNLEE-ADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-C 225 Query: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290 +L L +++ + Y ++ A+ +H + +V+ DLK N ++ DG +K+ Sbjct: 226 GNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIH-QHGIVHSDLKPANFLIV-DGMLKL 283 Query: 291 TDFGLCKEGIKDGATM--KTFCGTPEYLAPEVLEDNDYGRA-----------VDWWGLGV 337 DFG+ + D ++ + GT Y+ PE ++D R D W LG Sbjct: 284 IDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGC 343 Query: 338 VMYEMMCGRLPFYNQDHE--KLFELI-LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGG 394 ++Y M G+ PF ++ KL +I EI FP + + +L LK+DPKQR+ Sbjct: 344 ILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRIS- 402 Query: 395 GSEDAKEIMQHRFFA 409 E++ H + Sbjct: 403 ----IPELLAHPYVQ 413 >1U59-A nrPDB Length = 287 Score = 210 bits (536), Expect = 7e-55, Method: Composition-based stats. Identities = 61/245 (24%), Positives = 98/245 (40%), Gaps = 12/245 (4%) Query: 155 LLGKGTFGKVILVKEKATGRY--YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 LG G FG V + + A+K+LK+ K + + E +++ +P++ Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVR 74 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 L Q L VME A GG L L + ++ + YL EKN V Sbjct: 75 LIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL-EEKNFV 132 Query: 272 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE---YLAPEVLEDNDYGR 328 +RDL N++L + KI+DFGL K D + + APE + + Sbjct: 133 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 192 Query: 329 AVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPEAKSLLSGLLKK 386 D W GV M+E + G+ P+ ++ I + + P PE +L+S Sbjct: 193 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 252 Query: 387 DPKQR 391 + R Sbjct: 253 KWEDR 257 >5HLW-A nrPDB Length = 299 Score = 210 bits (536), Expect = 7e-55, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 109/257 (42%), Gaps = 14/257 (5%) Query: 151 EYLKLLGKGTFGKVI---LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + +++G+G FG V L+ + A+K L + I EV+ LTE ++++ H Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSH 80 Query: 208 PFLTALKYSF-QTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLH 265 P + +L ++ V+ Y G+L + E + +G ++ + YL Sbjct: 81 PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLA 140 Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM---KTFCGTP-EYLAPEVL 321 S+K V+RDL N MLD+ +K+ DFGL ++ KT P +++A E L Sbjct: 141 SKK-FVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESL 199 Query: 322 EDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKL-FELILMEEIRFPRTLGPEAKSL 379 + + D W GV+++E+M G P+ + + + L+ + P + Sbjct: 200 QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEV 259 Query: 380 LSGLLKKDPKQRLGGGS 396 + + R Sbjct: 260 MLKCWHPKAEMRPSFSE 276 >5O0Y-A nrPDB Length = 579 Score = 210 bits (536), Expect = 8e-55, Method: Composition-based stats. Identities = 81/258 (31%), Positives = 119/258 (46%), Gaps = 26/258 (10%) Query: 161 FGKVILVKEKATGRYYAMKI--LKKEVIVAKDE--VAHTLTENRVLQNSRHPFLTALKYS 216 F +V + RY A+KI L K K E H E R+ + HP + L Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 217 FQ-THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS-EKNVVYRD 274 F D C V+EY G +L F+L + ++ SE AR +IV+AL YL+ + +++ D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 275 LKLENLMLDKD---GHIKITDFGLCKEGIKDGAT-------MKTFCGTPEYLAPEVL--- 321 LK N++L G IKITDFGL K D GT YL PE Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG 476 Query: 322 -EDNDYGRAVDWWGLGVVMYEMMCGRLPF-YNQDHEKLFE---LILMEEIRFPRT--LGP 374 E VD W +GV+ Y+ + GR PF +NQ + + + ++ E++FP + P Sbjct: 477 KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTP 536 Query: 375 EAKSLLSGLLKKDPKQRL 392 EAK+ + L + R+ Sbjct: 537 EAKAFIRRCLAYRKEDRI 554 >2OZO-A nrPDB Length = 613 Score = 210 bits (536), Expect = 8e-55, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 111/308 (36%), Gaps = 27/308 (8%) Query: 103 IQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP-----------KHRVTMNEFE 151 I T+ E + E + P + + + + E Sbjct: 284 IDTLNSDGYTPEPARITSPDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIE 343 Query: 152 YLKLLGKGTFGKVILVKEKATGRY--YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 LG G FG V + + A+K+LK+ K + + E +++ +P+ Sbjct: 344 ----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPY 397 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYLHSEK 268 + L Q L VME A GG L L + ++ + YL EK Sbjct: 398 IVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL-EEK 455 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE---YLAPEVLEDND 325 N V+R+L N++L + KI+DFGL K D + + APE + Sbjct: 456 NFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 Query: 326 YGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPEAKSLLSGL 383 + D W GV M+E + G+ P+ ++ I + + P PE +L+S Sbjct: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 Query: 384 LKKDPKQR 391 + R Sbjct: 576 WIYKWEDR 583 >4IDT-A nrPDB Length = 356 Score = 210 bits (535), Expect = 9e-55, Method: Composition-based stats. Identities = 73/280 (26%), Positives = 118/280 (42%), Gaps = 20/280 (7%) Query: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 LG+G+FG+V +++K TG A+K ++ EV A+ E P + L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE--------ELMACAGLTSPRIVPLYG 133 Query: 216 SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 + + + ME GG L + + EDRA +Y + + L+YLHS + +++ D+ Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRR-ILHGDV 192 Query: 276 KLENLMLDKDG-HIKITDFGLCKEGIKDG-----ATMKTFCGTPEYLAPEVLEDNDYGRA 329 K +N++L DG H + DFG DG T GT ++APEV+ Sbjct: 193 KADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAK 252 Query: 330 VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI---RFPRTLGPEAKSLLSGLLKK 386 VD W +M M+ G P+ L I E P + P + L+K Sbjct: 253 VDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRK 312 Query: 387 DPKQRLGGGSEDAKEIMQHRFFAGI--VWQHVYEKKLSPP 424 +P R+ K + G+ W+ Y++ PP Sbjct: 313 EPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPP 352 >4E7W-A nrPDB Length = 394 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 76/319 (23%), Positives = 132/319 (41%), Gaps = 58/319 (18%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 + K++G G+FG V K + A+K + ++ E ++++ +HP Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN-------RELQIMRIVKHPN 93 Query: 210 LTALKYSFQTHDR------LCFVMEYAN---GGELFFHLSRERVFSEDRARFYGAEIVSA 260 + LK F ++ L V+EY + ++ + Y +++ + Sbjct: 94 VVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRS 153 Query: 261 LDYLHSEKNVVYRDLKLENLMLDK-DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 L Y+HS + +RD+K +NL+LD G +K+ DFG K I + C + Y APE Sbjct: 154 LAYIHS-IGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYIC-SRYYRAPE 211 Query: 320 VLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH-EKLFELILM-------------- 363 ++ +Y +D W G VM E+M G+ F + ++L E+I + Sbjct: 212 LIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNP 271 Query: 364 --EEIRFP------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 E +FP P+A L+S LL+ P RL A E + H FF Sbjct: 272 NYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARL-----TAIEALCHPFFD 326 Query: 410 GIVW---QHVYEKKLSPPF 425 + + ++L P F Sbjct: 327 ELRTGEARMPNGRELPPLF 345 >2I6L-A nrPDB Length = 320 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 73/311 (23%), Positives = 120/311 (38%), Gaps = 60/311 (19%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + + LK LG G G V + + A+K + V+ V H L E ++++ H Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALREIKIIRRLDH 67 Query: 208 PFLTALK--------------YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253 + + S + + V EY +L L + E+ AR + Sbjct: 68 DNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVLEQ-GPLLEEHARLF 125 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKE---GIKDGATMKTF 309 +++ L Y+HS NV++RDLK NL ++ +D +KI DFGL + + Sbjct: 126 MYQLLRGLKYIHS-ANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 184 Query: 310 CGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL------ 362 T Y +P +L N+Y +A+D W G + EM+ G+ F + +LIL Sbjct: 185 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 244 Query: 363 -------------------MEEIRFP-----RTLGPEAKSLLSGLLKKDPKQRLGGGSED 398 M E P + EA L +L P RL Sbjct: 245 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRL-----T 299 Query: 399 AKEIMQHRFFA 409 A+E + H + + Sbjct: 300 AEEALSHPYMS 310 >4OW8-A nrPDB Length = 283 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 74/269 (27%), Positives = 111/269 (41%), Gaps = 9/269 (3%) Query: 140 KPKHRVTM-NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 P+ VT+ + +L+ G G+V + GR A+K+LK E + + E Sbjct: 2 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 61 Query: 199 NRVLQNSRHPFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253 R HP + ++ ++ VME NG L L R S A Sbjct: 62 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 121 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GT 312 + AL H+ +V+RD+K N+++ G +KITDFG+ K T GT Sbjct: 122 LEQTGRALQIAHA-AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGT 180 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL-FELILMEEIRFPRT 371 +Y+APE +D A D + LGVV YE + G+ PF + + I P Sbjct: 181 AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPD 240 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 L P + L+ L K+P R G A Sbjct: 241 LPPNVRELIEITLVKNPAMRYRSGGPFAD 269 >4X3F-A nrPDB Length = 337 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 74/269 (27%), Positives = 111/269 (41%), Gaps = 9/269 (3%) Query: 140 KPKHRVTM-NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 P+ VT+ + +L+ G G+V + GR A+K+LK E + + E Sbjct: 3 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 62 Query: 199 NRVLQNSRHPFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253 R HP + ++ ++ VME NG L L R S A Sbjct: 63 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 122 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GT 312 + AL H+ +V+RD+K N+++ G +KITDFG+ K T GT Sbjct: 123 LEQTGRALQIAHA-AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGT 181 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL-FELILMEEIRFPRT 371 +Y+APE +D A D + LGVV YE + G+ PF + + I P Sbjct: 182 AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPD 241 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 L P + L+ L K+P R G A Sbjct: 242 LPPNVRELIEITLVKNPAMRYRSGGPFAD 270 >6B2Q-A nrPDB Length = 317 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 74/269 (27%), Positives = 111/269 (41%), Gaps = 9/269 (3%) Query: 140 KPKHRVTM-NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 P+ VT+ + +L+ G G+V + GR A+K+LK E + + E Sbjct: 23 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 82 Query: 199 NRVLQNSRHPFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253 R HP + ++ ++ VME NG L L R S A Sbjct: 83 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 142 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GT 312 + AL H+ +V+RD+K N+++ G +KITDFG+ K T GT Sbjct: 143 LEQTGRALQIAHA-AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGT 201 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL-FELILMEEIRFPRT 371 +Y+APE +D A D + LGVV YE + G+ PF + + I P Sbjct: 202 AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPD 261 Query: 372 LGPEAKSLLSGLLKKDPKQRLGGGSEDAK 400 L P + L+ L K+P R G A Sbjct: 262 LPPNVRELIEITLVKNPAMRYRSGGPFAD 290 >1ZXE-A nrPDB Length = 303 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 129/295 (43%), Gaps = 47/295 (15%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++FE + +LG+G FG+V+ + RYYA+K ++ +++++ L+E +L + H Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH----TEEKLSTILSEVMLLASLNH 61 Query: 208 PFLTALKYSFQT-------------HDRLCFVMEYANGGELFFHLSRERVFSE-DRARFY 253 ++ ++ L MEY L+ + E + + D Sbjct: 62 QYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRL 121 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK------------ 301 +I+ AL Y+HS+ +++R+LK N+ +D+ ++KI DFGL K + Sbjct: 122 FRQILEALSYIHSQ-GIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNL 180 Query: 302 --DGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFY-NQDHEKL 357 + + GT Y+A EVL+ Y +D + LG++ +EM+ PF + + Sbjct: 181 PGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNI 237 Query: 358 FELILMEEIRFPRTLGPE----AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + + I FP K ++ L+ DP +R A+ ++ + Sbjct: 238 LKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKR-----PGARTLLNSGWL 287 >4EQM-A nrPDB Length = 294 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 52/265 (19%), Positives = 108/265 (40%), Gaps = 7/265 (2%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 ++ ++ + LG G V L ++ A+K + ++ + E Sbjct: 7 KIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSS 66 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 H + ++ + D VMEY G L ++ S D A + +I+ + + Sbjct: 67 QLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKH 126 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GTPEYLAPEVLE 322 H + +V+RD+K +N+++D + +KI DFG+ K + T GT +Y +PE + Sbjct: 127 AH-DMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAK 185 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI-----RFPRTLGPEAK 377 D + +G+V+YEM+ G PF + + + + + + + Sbjct: 186 GEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSLS 245 Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEI 402 +++ +KD R E ++ Sbjct: 246 NVILRATEKDKANRYKTIQEMKDDL 270 >4HVI-A nrPDB Length = 314 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 72/280 (25%), Positives = 111/280 (39%), Gaps = 38/280 (13%) Query: 149 EFEYLKLLGKGTFGKVILVK----EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 +Y+ LGKG FG V L + TG A+K L+ D+ E ++L+ Sbjct: 11 HLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS---GPDQQRDFQREIQILKA 67 Query: 205 SRHPFLTALKYSFQTHDR--LCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSAL 261 F+ + R L VMEY G L L R R R Y ++I + Sbjct: 68 LHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGM 127 Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG--IKDGATMKTFCGTP-EYLAP 318 +YL S + V+RDL N++++ + H+KI DFGL K KD ++ +P + AP Sbjct: 128 EYLGSRR-CVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAP 186 Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM--------------- 363 E L DN + R D W GVV+YE+ + ++ E + M Sbjct: 187 ESLSDNIFSRQSDVWSFGVVLYELFT----YCDKSCSPSAEFLRMMGSERDVPALSRLLE 242 Query: 364 -----EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSED 398 + + P E L+ P+ R + Sbjct: 243 LLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALG 282 >3BGP-A nrPDB Length = 333 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 67/272 (24%), Positives = 123/272 (45%), Gaps = 22/272 (8%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA---HTLTENRVLQN 204 ++++ LLG G FG V + A+K ++K+ I E+ E +L+ Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 205 SRHPF--LTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSAL 261 F + L F+ D ++E +LF ++ E+ AR + +++ A+ Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 175 Query: 262 DYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 + H+ V++RD+K EN+++D G +K+ DFG + F GT Y PE Sbjct: 176 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFG--SGALLKDTVYTDFDGTRVYSPPEW 232 Query: 321 LEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379 + + Y GR+ W LG+++Y+M+CG +PF + E I+ ++ F + + E + L Sbjct: 233 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHL 286 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 + L P R +EI H + + Sbjct: 287 IRWCLALRPSDR-----PTFEEIQNHPWMQDV 313 >5AP3-A nrPDB Length = 313 Score = 207 bits (528), Expect = 7e-54, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 123/304 (40%), Gaps = 32/304 (10%) Query: 124 SPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK 183 S + G E + K R+ + LK +G G KV V + + YA+K + Sbjct: 8 SSGVDLGTENLYFQSMSVKGRI----YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNL 62 Query: 184 EVIVAKDEVAHTLTENRVLQNS--RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR 241 E + E L + L T + VME +L L + Sbjct: 63 EE-ADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKK 120 Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 ++ + Y ++ A+ +H + +V+ DLK N ++ DG +K+ DFG+ + Sbjct: 121 KKSIDPWERKSYWKNMLEAVHTIH-QHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQP 178 Query: 302 DGATM--KTFCGTPEYLAPEVLEDNDYGRA-----------VDWWGLGVVMYEMMCGRLP 348 D ++ + GT Y+ PE ++D R D W LG ++Y M G+ P Sbjct: 179 DTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTP 238 Query: 349 FYNQDHE--KLFELI-LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 F ++ KL +I EI FP + + +L LK+DPKQR+ E++ H Sbjct: 239 FQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRIS-----IPELLAH 293 Query: 406 RFFA 409 + Sbjct: 294 PYVQ 297 >4F0G-A nrPDB Length = 287 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 116/271 (42%), Gaps = 25/271 (9%) Query: 141 PKHRVTM---NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL----KKEVIVAKDEVA 193 PK R+ NE EY K +GKG FG V + A+K L + ++ Sbjct: 9 PKSRLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQ 68 Query: 194 HTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL-SRERVFSEDRARF 252 E ++ N HP + L R VME+ G+L+ L + Sbjct: 69 EFQREVFIMSNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLR 126 Query: 253 YGAEIVSALDYLHSEKN-VVYRDLKLENLML---DKDGHI--KITDFGLCKEGIKDGATM 306 +I ++Y+ ++ +V+RDL+ N+ L D++ + K+ DFGL ++ + + Sbjct: 127 LMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS---V 183 Query: 307 KTFCGTPEYLAPEVL--EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL--FELIL 362 G +++APE + E+ Y D + +++Y ++ G PF + K+ +I Sbjct: 184 SGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIR 243 Query: 363 MEEIR--FPRTLGPEAKSLLSGLLKKDPKQR 391 E +R P P ++++ DPK+R Sbjct: 244 EEGLRPTIPEDCPPRLRNVIELCWSGDPKKR 274 >5TUR-A nrPDB Length = 404 Score = 207 bits (527), Expect = 9e-54, Method: Composition-based stats. Identities = 67/272 (24%), Positives = 123/272 (45%), Gaps = 22/272 (8%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA---HTLTENRVLQN 204 ++++ LLG G FG V + A+K ++K+ I E+ E +L+ Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 205 SRHPF--LTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSAL 261 F + L F+ D ++E +LF ++ E+ AR + +++ A+ Sbjct: 187 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 246 Query: 262 DYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 + H+ V++RD+K EN+++D G +K+ DFG + F GT Y PE Sbjct: 247 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFG--SGALLKDTVYTDFDGTRVYSPPEW 303 Query: 321 LEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379 + + Y GR+ W LG+++Y+M+CG +PF + E I+ ++ F + + E + L Sbjct: 304 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHL 357 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 + L P R +EI H + + Sbjct: 358 IRWCLALRPSDR-----PTFEEIQNHPWMQDV 384 >3LZB-A nrPDB Length = 327 Score = 207 bits (527), Expect = 9e-54, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 100/253 (39%), Gaps = 13/253 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYY----AMKILKKEVIVAKDEVAHTLTENRVLQ 203 EF+ +K+LG G FG V G A+K L++ + L E V+ Sbjct: 15 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT--SPKANKEILDEAYVMA 72 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALD 262 + +P + L T + + + G L ++ + + +I ++ Sbjct: 73 SVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMN 131 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEV 320 YL ++ +V+RDL N+++ H+KITDFGL K + G +++A E Sbjct: 132 YL-EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 190 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPEAKS 378 + Y D W GV ++E+M G P+ ++ ++ E + P + Sbjct: 191 ILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM 250 Query: 379 LLSGLLKKDPKQR 391 ++ D R Sbjct: 251 IMRKCWMIDADSR 263 >4X7Q-B nrPDB Length = 312 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 71/272 (26%), Positives = 126/272 (46%), Gaps = 24/272 (8%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT---ENRVL--- 202 E+ LLGKG FG V A+K++ + ++ ++ ++T E +L Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 203 -QNSRHPFLTALKYSFQTHDRLCFVMEY-ANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 HP + L F+T + V+E +LF +++ + E +R + ++V+A Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 261 LDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319 + + HS + VV+RD+K EN+++D + G K+ DFG + T F GT Y PE Sbjct: 152 IQHCHS-RGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYT--DFDGTRVYSPPE 208 Query: 320 VLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378 + + Y W LG+++Y+M+CG +PF + + IL E+ FP + P+ + Sbjct: 209 WISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILEAELHFPAHVSPDCCA 262 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410 L+ L P R +EI+ + Sbjct: 263 LIRRCLAPKPSSR-----PSLEEILLDPWMQT 289 >4RC3-A nrPDB Length = 289 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 67/272 (24%), Positives = 123/272 (45%), Gaps = 22/272 (8%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA---HTLTENRVLQN 204 ++++ LLG G FG V + A+K ++K+ I E+ E +L+ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 205 SRHPF--LTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSAL 261 F + L F+ D ++E +LF ++ E+ AR + +++ A+ Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 131 Query: 262 DYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 + H+ V++RD+K EN+++D G +K+ DFG + F GT Y PE Sbjct: 132 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFG--SGALLKDTVYTDFDGTRVYSPPEW 188 Query: 321 LEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379 + + Y GR+ W LG+++Y+M+CG +PF + E I+ ++ F + + E + L Sbjct: 189 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHL 242 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 + L P R +EI H + + Sbjct: 243 IRWCLALRPSDR-----PTFEEIQNHPWMQDV 269 >3E3P-A nrPDB Length = 360 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 130/322 (40%), Gaps = 61/322 (18%) Query: 135 EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH 194 + A + R M+ F+ ++ G+GTFG V L KEK+TG A+K + ++ Sbjct: 10 AAAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN----- 64 Query: 195 TLTENRVLQN---SRHPFLTALKYSFQTHD-------RLCFVMEYAN---GGELFFHLSR 241 E +++Q+ HP + L+ F T L VMEY + R Sbjct: 65 --RELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRR 122 Query: 242 ERVFSEDRARFYGAEIVSALDYLH-SEKNVVYRDLKLENLMLDK-DGHIKITDFGLCKEG 299 + + + +++ ++ LH NV +RD+K N+++++ DG +K+ DFG K+ Sbjct: 123 QVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKL 182 Query: 300 IKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 358 + C + Y APE++ N Y AVD W +G + EMM G F + Sbjct: 183 SPSEPNVAYIC-SRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQL 241 Query: 359 ELILM-------------------------EEIRFPRTLGP-------EAKSLLSGLLKK 386 I+ + I + EA LLS LL+ Sbjct: 242 HEIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQY 301 Query: 387 DPKQRLGGGSEDAKEIMQHRFF 408 P++R+ E + H +F Sbjct: 302 LPEERMKPY-----EALCHPYF 318 >3PP0-A nrPDB Length = 338 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 99/253 (39%), Gaps = 13/253 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYY----AMKILKKEVIVAKDEVAHTLTENRVLQ 203 E +K+LG G FG V G A+K+L++ + L E V+ Sbjct: 17 TELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENT--SPKANKEILDEAYVMA 74 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALD 262 P+++ L T + V + G L H+ R + +I + Sbjct: 75 GVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMS 133 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEV 320 YL + +V+RDL N+++ H+KITDFGL + D G +++A E Sbjct: 134 YLEDVR-LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALES 192 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPEAKS 378 + + D W GV ++E+M G P+ ++ +L+ E + P + Sbjct: 193 ILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM 252 Query: 379 LLSGLLKKDPKQR 391 ++ D + R Sbjct: 253 IMVKCWMIDSECR 265 >5GNK-A nrPDB Length = 297 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 55/253 (21%), Positives = 101/253 (39%), Gaps = 13/253 (5%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYY----AMKILKKEVIVAKDEVAHTLTENRVLQ 203 EF+ +K+LG G FG V G A+K L++ + L E V+ Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT--SPKANKEILDEAYVMA 76 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALD 262 + +P + L T + +M+ G L ++ + + +I ++ Sbjct: 77 SVDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMN 135 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLAPEV 320 YL ++ +V+RDL N+++ H+KITDFGL K + G +++A E Sbjct: 136 YL-EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 194 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPEAKS 378 + Y D W GV ++E+M G P+ ++ ++ E + P + Sbjct: 195 ILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM 254 Query: 379 LLSGLLKKDPKQR 391 ++ D R Sbjct: 255 IMVKCWMIDADSR 267 >3PLS-A nrPDB Length = 298 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 60/262 (22%), Positives = 109/262 (41%), Gaps = 17/262 (6%) Query: 141 PKHRVTMNEFEYLKLLGKGTFGKVI--LVKEKATGRY-YAMKILKKEVIVAKDEVAHTLT 197 P RV +++GKG FG V ++A R A+K L + I +V L Sbjct: 17 PHERVVT---HSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR--ITEMQQVEAFLR 71 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRL-CFVMEYANGGELFFHLSR-ERVFSEDRARFYGA 255 E +++ HP + AL + L ++ Y G+L + +R + +G Sbjct: 72 EGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGL 131 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT----MKTFCG 311 ++ ++YL +K V+RDL N MLD+ +K+ DFGL ++ + + Sbjct: 132 QVARGMEYLAEQK-FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARL 190 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFP 369 ++ A E L+ + D W GV+++E++ G P+ + D L + + P Sbjct: 191 PVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQP 250 Query: 370 RTLGPEAKSLLSGLLKKDPKQR 391 ++ + DP R Sbjct: 251 EYCPDSLYQVMQQCWEADPAVR 272 >3AOX-A nrPDB Length = 344 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 52/268 (19%), Positives = 102/268 (38%), Gaps = 22/268 (8%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVK-----EKATGRYYAMKILKKEVIVAKDEVAHTLT 197 V ++ LG G FG+V + + A+K L EV +DE+ L Sbjct: 42 KEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL-PEVCSEQDEL-DFLM 99 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-------FSEDRA 250 E ++ H + ++E GG+L L R + Sbjct: 100 EALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDL 159 Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG---HIKITDFGLCKEGIKDGATMK 307 +I YL E + ++RD+ N +L G KI DFG+ ++ + K Sbjct: 160 LHVARDIACGCQYL-EENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRK 218 Query: 308 TFCGTP--EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM- 363 C +++ PE + + D W GV+++E+ G +P+ ++ ++++ E + Sbjct: 219 GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG 278 Query: 364 EEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 + P+ +++ + P+ R Sbjct: 279 GRMDPPKNCPGPVYRIMTQCWQHQPEDR 306 >5TQX-A nrPDB Length = 655 Score = 204 bits (518), Expect = 9e-53, Method: Composition-based stats. Identities = 81/298 (27%), Positives = 126/298 (42%), Gaps = 44/298 (14%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +E + LG G FG V L + + A+K + E+ E E ++++ H Sbjct: 8 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRE--RWCHEIQIMKKLNH 65 Query: 208 PFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVS 259 + + HD MEY +GG+L L++ E + ++I S Sbjct: 66 ANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGS 125 Query: 260 ALDYLHSEKNVVYRDLKLENLML-DKDGHI--KITDFGLCKEGIKDGATMKTFCGTPEYL 316 + YLH K +++RDLK EN++L D G I KI D G K+ + G F GT +YL Sbjct: 126 GIRYLHENK-IIHRDLKPENIVLQDVGGKIIHKIIDLGYAKD-VDQGELCTEFVGTLQYL 183 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF-YNQDHEKLFELI-------------L 362 APE+ E+ Y VD+W G +++E + G PF ++ E I + Sbjct: 184 APELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEM 243 Query: 363 MEEIRFPRTLGP--EAKSLL--------SGLLKKDPKQRLGGGSEDAKE-----IMQH 405 E+RF L SL+ +L DP+QR G K+ +M H Sbjct: 244 SGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDH 301 >3M42-A nrPDB Length = 299 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 79/290 (27%), Positives = 124/290 (42%), Gaps = 53/290 (18%) Query: 137 SLAKPKHRVTMNEFEY-LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 195 S + K +++++ ++LG G GKV+ + K T +A+K+L ++ A+ EV Sbjct: 6 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-QDCPKARREVELH 64 Query: 196 LTENRVLQNSRHPFLTALKYSFQT----HDRLCFVMEYANGGELFFHLSRER--VFSEDR 249 S+ P + + ++ L VME +GGELF + F+E Sbjct: 65 WR------ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 118 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATM 306 A I A+ YLHS N+ +RD+K ENL+ + +K+TDFG KE Sbjct: 119 ASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT------ 171 Query: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL----FELIL 362 Y ++ D W LGV+MY ++CG PFY+ + I Sbjct: 172 ----------------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 215 Query: 363 MEEIRFPRT----LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 M + FP + E K L+ LLK +P QR+ E M H + Sbjct: 216 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWI 260 >5HVK-A nrPDB Length = 315 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 120/303 (39%), Gaps = 29/303 (9%) Query: 139 AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 ++P ++ + ++LGKG FG+ I V + TG MK L + ++ L E Sbjct: 5 SRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR---FDEETQRTFLKE 61 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEI 257 +V++ HP + RL F+ EY GG L + + + + + +I Sbjct: 62 VKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDI 121 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK--------------DG 303 S + YLHS N+++R+L N ++ ++ ++ + DFGL + + D Sbjct: 122 ASGMAYLHS-MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDR 180 Query: 304 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG---RLPFYNQDHEKLFEL 360 T G P ++APE++ Y VD + G+V+ E++ + + + + Sbjct: 181 KKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNV 240 Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420 + P P + DP++R ++H + + Sbjct: 241 RGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVK------LEH-WLETLRMHLAGHLP 293 Query: 421 LSP 423 L P Sbjct: 294 LGP 296 >3N9X-A nrPDB Length = 432 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 73/403 (18%), Positives = 143/403 (35%), Gaps = 100/403 (24%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K+ + + L+G+G++G V L +K T + A+K + + D L E + Sbjct: 20 KNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLID-CKRILREITI 78 Query: 202 LQNSRHPFLTALKYSFQTHD-----RLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 L + ++ L D L V+E A+ +L +E+ + Sbjct: 79 LNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKTILYN 137 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT----------- 305 ++ +++H E +++RDLK N +L++D +K+ DFGL + + T Sbjct: 138 LLLGENFIH-ESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEE 196 Query: 306 -----------MKTFCGTPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEMM---------- 343 + + T Y APE +L +Y +++D W G + E++ Sbjct: 197 PGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDP 256 Query: 344 -CGRLPFYNQ-----------------------------------------DHEKLFELI 361 F + ++ + I Sbjct: 257 TNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYI 316 Query: 362 LMEEIRFP-------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQ 414 + R P ++ + +LL +LK +P +R+ + + H + + + Sbjct: 317 KLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRI-----TIDQALDHPYLKDVRKK 371 Query: 415 HVYE---KKLSPPFKP-QVTSETDTRY-FDEEFTAQMITITPP 452 + KK+ PF V SET RY F +E + + P Sbjct: 372 KLENFSTKKIILPFDDWMVLSETQLRYIFLKEVQSFHPELVIP 414 >2X18-A nrPDB Length = 119 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 98/119 (82%), Positives = 107/119 (89%), Gaps = 1/119 (0%) Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60 MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD PLNNFSVA+C Sbjct: 2 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 60 Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMD 119 QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+ Sbjct: 61 QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMN 119 >3NIE-A nrPDB Length = 429 Score = 202 bits (513), Expect = 4e-52, Method: Composition-based stats. Identities = 69/391 (17%), Positives = 133/391 (34%), Gaps = 101/391 (25%) Query: 128 NSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIV 187 +SG E + A K+ + +E L+G+G++G V L +K + A+K + + Sbjct: 8 SSGRENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFED 67 Query: 188 AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHD-----RLCFVMEYANGGELFFHLSRE 242 D L E +L + ++ L D L V+E A+ +L Sbjct: 68 LID-CKRILREITILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTP 125 Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD 302 +E + ++ ++H E +++RDLK N +L++D +KI DFGL + D Sbjct: 126 IFLTEQHVKTILYNLLLGEKFIH-ESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSD 184 Query: 303 GA-------------------------TMKTFCGTPEYLAPE-VLEDNDYGRAVDWWGLG 336 + + T Y APE +L +Y ++D W G Sbjct: 185 KDIHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTG 244 Query: 337 VVMYEMM-----------CGRLPFYNQD-------------------------------- 353 + E++ F Sbjct: 245 CIFAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTP 304 Query: 354 HEKLFELILMEEI-----RFP-----------RTLGPEAKSLLSGLLKKDPKQRLGGGSE 397 E+ + I +E+ FP ++ E LL +L+ + ++R+ Sbjct: 305 PEEDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRI----- 359 Query: 398 DAKEIMQHRFFAGI---VWQHVYEKKLSPPF 425 + + H + + ++ +K+ PF Sbjct: 360 TIDKALSHPYLKDVRKENLENFSTEKIILPF 390 >4M7I-A nrPDB Length = 299 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 119/297 (40%), Gaps = 42/297 (14%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 + +FE ++ LG+G FG V K K YA+K ++ E + E + L Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELARE--KVMREVKALAKLE 61 Query: 207 HPFLTALKYSFQTHD------------RLCFVMEYANGGELFFHLSRERVFSEDRA---R 251 HP + ++ + L M+ L ++ E Sbjct: 62 HPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCL 121 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA------- 304 +I A+++LHS K +++RDLK N+ D +K+ DFGL +D Sbjct: 122 HIFLQIAEAVEFLHS-KGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTP 180 Query: 305 -----TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 359 GT Y++PE + N Y VD + LG++++E++ PF Q E++ Sbjct: 181 MPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL---YPFSTQ-MERVRT 236 Query: 360 LILMEEIRFPRTLG---PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413 L + ++FP P ++ +L P +R +A I+++ F + + Sbjct: 237 LTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMER-----PEAINIIENAVFEDLDF 288 >3PG1-A nrPDB Length = 362 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 116/311 (37%), Gaps = 56/311 (18%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV--------AHTLTEN 199 + + + + G++G V + + G A+K + V + L E Sbjct: 22 SPYTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREI 80 Query: 200 RVLQNSRHPFLTALKYSFQTHDR-----LCFVMEYANGGELFFHLSRER-VFSEDRARFY 253 R+L + HP + L+ F + L V E +L + +R V S +++ Sbjct: 81 RLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMR-TDLAQVIHDQRIVISPQHIQYF 139 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP 313 I+ L LH E VV+RDL N++L + I I DF L +E D + Sbjct: 140 MYHILLGLHVLH-EAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTH-YVTHR 197 Query: 314 EYLAPE-VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM--EEIRFPR 370 Y APE V++ + + VD W G VM EM + F I+ + Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIED 257 Query: 371 TL---GPEAK---------------------------SLLSGLLKKDPKQRLGGGSEDAK 400 + P A+ L++ +L+ +P++R+ + Sbjct: 258 VVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRIST-----E 312 Query: 401 EIMQHRFFAGI 411 + ++H +F + Sbjct: 313 QALRHPYFESL 323 >6CTH-A nrPDB Length = 309 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 59/206 (28%), Positives = 90/206 (43%), Gaps = 7/206 (3%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + F LG+G FG V + + Y A+K + + +K + +E +++ Sbjct: 13 VTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSR---ASKQGIKEYASEVKIISRL 69 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF-YGAEIVSALDYL 264 RH L L L V E+ G L H+ + + R+ ++ SAL YL Sbjct: 70 RHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYL 129 Query: 265 HSE--KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT-FCGTPEYLAPEVL 321 H E V++RD+K N+MLD + K+ DFGL + KT GT Y+APE L Sbjct: 130 HEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECL 189 Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRL 347 + D + GVV E+ GR Sbjct: 190 SSGKASKESDVYSFGVVALEIASGRR 215 >2A1A-B nrPDB Length = 284 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 69/276 (25%), Positives = 116/276 (42%), Gaps = 40/276 (14%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 +F+ ++L+G G FG+V K + G+ Y +K +K E + L H Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-------EKAEREVKALAKLDHV 64 Query: 209 FLTALKYSFQTHDR----------------LCFVMEYANGGELFFHLSRERV--FSEDRA 250 + + D L ME+ + G L + + R + A Sbjct: 65 NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 124 Query: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC 310 +I +DY+HS+K ++ RDLK N+ L +KI DFGL DG ++ Sbjct: 125 LELFEQITKGVDYIHSKK-LINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK- 182 Query: 311 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM--CGRLPFYNQDHEKLFELILMEEIRF 368 GT Y++PE + DYG+ VD + LG+++ E++ C ++ L + I Sbjct: 183 GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGI------I 236 Query: 369 PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 + K+LL LL K P+ R + EI++ Sbjct: 237 SDIFDKKEKTLLQKLLSKKPEDR-----PNTSEILR 267 >4LRM-A nrPDB Length = 334 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 100/256 (39%), Gaps = 16/256 (6%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYY----AMKILKKEVIVAKDEVAHTLTENRVLQ 203 EF+ +K+LG G FG V G A+K L++ + L E V+ Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT--SPKANKEILDEAYVMA 76 Query: 204 NSRHP---FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVS 259 + +P + L T + + + G L ++ + + +I Sbjct: 77 SVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 135 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG--TPEYLA 317 ++YL ++ +V+RDL N+++ H+KITDFGL K + G +++A Sbjct: 136 GMNYL-EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 194 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPE 375 E + Y D W GV ++E+M G P+ ++ ++ E + P + Sbjct: 195 LESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 254 Query: 376 AKSLLSGLLKKDPKQR 391 ++ D R Sbjct: 255 VYMIMVKCWMIDADSR 270 >4TPT-A nrPDB Length = 303 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 68/269 (25%), Positives = 117/269 (43%), Gaps = 33/269 (12%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH-TLTENRVLQNSRH 207 + + ++LGKG FG+ I V KATG+ MK E+I +E LTE +V+++ H Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMK----ELIRCDEETQKTFLTEVKVMRSLDH 56 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P + +L + EY GG L L F + + I S + YLHS Sbjct: 57 PNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHS- 115 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK--------------------DGATMK 307 +++RDL N ++ D + + DFGL + ++ D Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRY 175 Query: 308 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD-HEKLFELILMEEI 366 T G P ++APE+L Y VD + G+V+ E++ G++ + + D + + L ++ Sbjct: 176 TVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQV-YADPDCLPRTLDFGLNVKL 233 Query: 367 RF----PRTLGPEAKSLLSGLLKKDPKQR 391 + P P L + + +P+ R Sbjct: 234 FWEKFVPTDCPPAFFPLAAICCRLEPESR 262 >4KIK-B nrPDB Length = 677 Score = 197 bits (502), Expect = 7e-51, Method: Composition-based stats. Identities = 86/381 (22%), Positives = 144/381 (37%), Gaps = 55/381 (14%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 T +E + LG G FG VI + TG A+K ++E ++ E ++++ Sbjct: 17 TCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQE--LSPRNRERWCLEIQIMRRL 74 Query: 206 RHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRER---VFSEDRARFYGAE 256 HP + A + + L MEY GG+L +L++ E ++ Sbjct: 75 THPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSD 134 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHI---KITDFGLCKEGIKDGATMKTFCGTP 313 I SAL YLH + +++RDLK EN++L + KI D G KE + G+ +F GT Sbjct: 135 IASALRYLHENR-IIHRDLKPENIVLQQGEQRLIHKIIDLGYAKE-LDQGSLCTSFVGTL 192 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF-YNQDHEKLFELILME-------- 364 +YLAPE+LE Y VD+W G + +E + G PF N + + + Sbjct: 193 QYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVS 252 Query: 365 -----------EIRFPRTLGPEAKSLLSG----LLKKDPKQRLGGGSED-------AKEI 402 + +P L L +L P+QR + +I Sbjct: 253 EDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDI 312 Query: 403 MQHRFFAGIVW-------QHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQD 455 + + + V E + K ++ +T D+E + PD+ Sbjct: 313 LNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKP 372 Query: 456 DSMECVDSERRP-HFPQFSYS 475 + D + H Sbjct: 373 ATQCISDGKLNEGHTLDMDLV 393 >5WNO-A nrPDB Length = 330 Score = 197 bits (502), Expect = 7e-51, Method: Composition-based stats. Identities = 64/253 (25%), Positives = 102/253 (40%), Gaps = 15/253 (5%) Query: 151 EYLKLLGKGTFGKVILV-----KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 + K LG G FG V + K A+K+ + + + + L E + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTD----QSQTDEMLEEATNMFRL 80 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSALDYL 264 RH L + D L V Y G L L + Y +I S + YL Sbjct: 81 RHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYL 140 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPEVLE 322 ++ VV+RDL N+++ K H++ITDFGL K + D T+K+ ++LA E+ Sbjct: 141 EKQR-VVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFS 199 Query: 323 DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME-EIRFPRTLGPEAKSLL 380 + Y A D W GV +E++ G+ P+ + + + + P + L Sbjct: 200 KHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQEL 259 Query: 381 SGLLKKDPKQRLG 393 DPK R G Sbjct: 260 LRCWMADPKSRPG 272 >4Y83-A nrPDB Length = 332 Score = 197 bits (501), Expect = 9e-51, Method: Composition-based stats. Identities = 56/256 (21%), Positives = 104/256 (40%), Gaps = 22/256 (8%) Query: 158 KGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSF 217 +G FGKV L ++ T + A K++ + D + RH + L + Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD--------VEIQACFRHENIAELYGAV 134 Query: 218 QTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKL 277 + + ME GG + L E + ++ LD+LHS+K V++ D+K Sbjct: 135 LWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKK-VIHHDIKP 193 Query: 278 ENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGV 337 N++ + + DFGL + +D K GT Y++PEV+ + D + LG Sbjct: 194 SNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGA 252 Query: 338 VMYEMMCGRLPF---YNQDHEKLFELILMEE----IRFPRTLGPEAKSLLSGLLKKDPKQ 390 + M G P+ Y + + I+ ++ P + L+ L+++P Sbjct: 253 TLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNH 312 Query: 391 RLGGGSEDAKEIMQHR 406 R A ++++H Sbjct: 313 R-----PRAADLLKHE 323 >3QA8-A nrPDB Length = 676 Score = 197 bits (501), Expect = 9e-51, Method: Composition-based stats. Identities = 68/233 (29%), Positives = 106/233 (45%), Gaps = 17/233 (7%) Query: 146 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 205 T +E + LG G FG V+ + TG A+K ++E+ E E ++++ Sbjct: 12 TCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRE--RWCLEIQIMKKL 69 Query: 206 RHPFLTALKYS------FQTHDRLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAE 256 HP + + + +D MEY GG+L +L++ E R ++ Sbjct: 70 NHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSD 129 Query: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHI---KITDFGLCKEGIKDGATMKTFCGTP 313 I SAL YLH + +++RDLK EN++L KI D G KE + G F GT Sbjct: 130 ISSALRYLHENR-IIHRDLKPENIVLQPGPQRLIHKIIDLGYAKE-LDQGELCTEFVGTL 187 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF-YNQDHEKLFELILMEE 365 +YLAPE+LE Y VD+W G + +E + G PF N + + + Sbjct: 188 QYLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKS 240 >5TOS-A nrPDB Length = 395 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 78/303 (25%), Positives = 118/303 (38%), Gaps = 50/303 (16%) Query: 133 EMEVSLAKPKHRVTMNE-------FEYLKLLGKGTFGKVILV---------KEKATGRYY 176 E E+ + P T NE F ++G+G FG V + TG Sbjct: 43 EGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVI 102 Query: 177 AMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELF 236 A+K L +E E LTE L HP L L + V E+ G L Sbjct: 103 AVKKLNQEGFQGHRE---WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLE 159 Query: 237 FHLSRE----RVFSEDRARFYGAEIVSALDYLHSEK-NVVYRDLKLENLMLDKDGHIKIT 291 HL R + + L +LHS+ V+YRD+K N++LD D + K++ Sbjct: 160 NHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS 219 Query: 292 DFGLCKEG-IKDGATMKTFC-GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR--- 346 DFGL ++G + D + + T GT Y APE + D + GV++ E++ G+ Sbjct: 220 DFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRAL 279 Query: 347 ---------------LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS---GLLKKDP 388 P+ + L LI+ + + L EA + S L +P Sbjct: 280 DHNRPAKEENLVDWARPYLTSKRKVL--LIVDNRLDT-QYLPEEAVRMASVAVQCLSFEP 336 Query: 389 KQR 391 K R Sbjct: 337 KSR 339 >4FL3-A nrPDB Length = 635 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 114/325 (35%), Gaps = 18/325 (5%) Query: 89 HVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMN 148 R+E T + L ++ R P D E E A P+ Sbjct: 306 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDT---EVFESPFADPEEIRPKE 362 Query: 149 EF---EYL----KLLGKGTFGKVILVK-EKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 + + L K LG G FG V + + K L E Sbjct: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 Query: 201 VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 V+Q +P++ + + VME A G L +L + R + ++ Sbjct: 423 VMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG 481 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE---YLA 317 + YL E N V+RDL N++L + KI+DFGL K D K + A Sbjct: 482 MKYL-EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPE 375 PE + + D W GV+M+E G+ P+ ++ ++ E + P E Sbjct: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAK 400 L++ D + R G + + + Sbjct: 601 MYDLMNLCWTYDVENRPGFAAVELR 625 >5WNL-A nrPDB Length = 342 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 112/278 (40%), Gaps = 20/278 (7%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 EF + +G G FG+V V+ + A+K + V E L E + ++ Sbjct: 17 FDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIK-CSPSLHVDDRERMELLEEAKKMEM 75 Query: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 ++ ++ + Q + + VMEY G L L+ E D E +++L Sbjct: 76 AKFRYILPVYGICQ--EPVGLVMEYMETGSLEKLLASE-PLPWDLRFRIVHETAVGMNFL 132 Query: 265 HS-EKNVVYRDLKLENLMLDKDGHIKITDFGLCK---EGIKDGATMKTFCGTPEYLAPEV 320 H +++ +LK N++LD H+KI+DFGL K +M GT YL PE Sbjct: 133 HCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPER 192 Query: 321 LEDND--YGRAVDWWGLGVVMYEMMCGRLPFYNQDH--EKLFELILMEEIRFPRTLGPEA 376 + + + D + +V++ ++ + PF ++ + + +++ P P Sbjct: 193 IREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRP 252 Query: 377 KS------LLSGLLKKDPKQRLGGGSED--AKEIMQHR 406 ++ L+ DP+ R +++ + Sbjct: 253 RACASLIGLMQRCWHADPQVRPTFQEITSETEDLCEKP 290 >5UIU-A nrPDB Length = 323 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 56/199 (28%), Positives = 84/199 (42%), Gaps = 10/199 (5%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV-AHTLTENRVLQNSRHPFLTAL 213 +G+G FG V T A+K L V + +E+ E +V+ +H L L Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSR---ERVFSEDRARFYGAEIVSALDYLHSEKNV 270 D LC V Y G L LS S + +++LH ++ Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 271 VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT--FCGTPEYLAPEVLEDNDYGR 328 +RD+K N++LD+ KI+DFGL + K T+ T GT Y+APE L Sbjct: 172 -HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-TP 229 Query: 329 AVDWWGLGVVMYEMMCGRL 347 D + GVV+ E++ G Sbjct: 230 KSDIYSFGVVLLEIITGLP 248 >5LPZ-A nrPDB Length = 332 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 117/319 (36%), Gaps = 43/319 (13%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 N F L+G G FG V K G A+K L E + E + +H Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE---FMAEMETIGKIKH 72 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV----FSEDRARFYGAEIVSALDY 263 L L + D V E+ G L L + + R L + Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 264 LHSE--KNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPE 319 LH ++++RD+K N++LD++ +++DFG+ + + ++ T GTP Y+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLP-----FYNQDHEKLFELILMEEIRFPRTLGP 374 + D + GVV+ E++ G+ P F + + + ++R P Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQ--HAKLRISDVFDP 250 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH-----RFFAGIVWQHVYEKKLSPPFKPQV 429 E L+K+DP + E++QH W+ ++ FK Sbjct: 251 E-------LMKEDPALEI--------ELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEIQ 295 Query: 430 TSETDTRYFDEEFTAQMIT 448 D + T + I Sbjct: 296 AG----SGIDSQSTIRSIE 310 >4NEU-A nrPDB Length = 333 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 69/268 (25%), Positives = 103/268 (38%), Gaps = 23/268 (8%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 ++ ++F L G FGKV L + G MK + K + L E +++ Sbjct: 20 KMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGP-NCIEHNEALLEEAKMMN 77 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263 RH + L + VMEY G L L E EI+ + Y Sbjct: 78 RLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCY 137 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC-------------KEGIKDGATMKTFC 310 LH K V+++DLK EN+++D D HIKI D GL E + T K Sbjct: 138 LHG-KGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG 196 Query: 311 GTPEYLAPEVLED--NDYGRAVDWWGLGVVMYEMMCGRLPFYN-QDHEKLFELILMEEI- 366 GT Y+APE L D D + VV++ + + P+ N ++L I Sbjct: 197 GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRP 256 Query: 367 ---RFPRTLGPEAKSLLSGLLKKDPKQR 391 E SL+ + +P+ R Sbjct: 257 DVDDITEYCPREIISLMKLCWEANPEAR 284 >5LPV-A nrPDB Length = 296 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 106/271 (39%), Gaps = 34/271 (12%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 N F L+G G FG V K G A+K L E + E + +H Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE---FMAEMETIGKIKH 72 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV----FSEDRARFYGAEIVSALDY 263 L L + D V E+ G L L + + R L + Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 264 LHSE--KNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPEYLAPE 319 LH ++++RD+K N++LD++ +++DFG+ + + ++ T GTP Y+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRLP-----FYNQDHEKLFELILMEEIRFPRTLGP 374 + D + GVV+ E++ G+ P F + + + ++R P Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQ--HAKLRISDVFDP 250 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 E L+K+DP + E++QH Sbjct: 251 E-------LMKEDPALEI--------ELLQH 266 >3EB0-A nrPDB Length = 383 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 126/337 (37%), Gaps = 86/337 (25%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 + ++ K LG G+FG V V + +G+ +A+K + ++ E +++ Sbjct: 3 ETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN-------RELDIMK 55 Query: 204 NSRHPFLTALKYSFQT--------------------------------------HDRLCF 225 H + L F T + L Sbjct: 56 VLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNV 115 Query: 226 VMEYAN---GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282 +MEY L + R + Y ++ A+ ++HS + +RD+K +NL++ Sbjct: 116 IMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHS-LGICHRDIKPQNLLV 174 Query: 283 D-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMY 340 + KD +K+ DFG K+ I ++ C + Y APE++ +Y ++D W +G V Sbjct: 175 NSKDNTLKLCDFGSAKKLIPSEPSVAYIC-SRFYRAPELMLGATEYTPSIDLWSIGCVFG 233 Query: 341 EMMCGRLPFYNQDHEKLFELILM-----------------EEIRFP-------RTLGPE- 375 E++ G+ F + I+ E+RFP R + PE Sbjct: 234 ELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEG 293 Query: 376 ----AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 A LL +L+ +P R+ E M H FF Sbjct: 294 TPSLAIDLLEQILRYEPDLRINPY-----EAMAHPFF 325 >3UIU-A nrPDB Length = 306 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 118/289 (40%), Gaps = 53/289 (18%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208 +F+ ++L+G G FG+V K + G+ Y ++ +K E + L H Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNN-------EKAEREVKALAKLDHV 65 Query: 209 FLTALKYSFQTHDR-----------------------------LCFVMEYANGGELFFHL 239 + + D L ME+ + G L + Sbjct: 66 NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWI 125 Query: 240 SRERVFSEDR--ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297 + R D+ A +I +DY+HS+K +++RDLK N+ L +KI DFGL Sbjct: 126 EKRRGEKLDKVLALELFEQITKGVDYIHSKK-LIHRDLKPSNIFLVDTKQVKIGDFGLVT 184 Query: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM--CGRLPFYNQDHE 355 DG ++ GT Y++PE + DYG+ VD + LG+++ E++ C ++ Sbjct: 185 SLKNDGKRTRSK-GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFT 243 Query: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 L + I + K+LL LL K P+ R + EI++ Sbjct: 244 DLRDGI------ISDIFDKKEKTLLQKLLSKKPEDR-----PNTSEILR 281 >5X8I-B nrPDB Length = 346 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 119/337 (35%), Gaps = 86/337 (25%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVK-EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 V +E + LG+G FGKV+ KA GR+ A+KI+K +E +VL Sbjct: 9 DVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYC----EAARSEIQVL 64 Query: 203 QNSR--HPF----LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS--EDRARFYG 254 ++ P + F+ H +C V E G + + D R Sbjct: 65 EHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMA 123 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDK-------------------DGHIKITDFGL 295 +I ++++LHS K + + DLK EN++ + + IK+ DFG Sbjct: 124 YQICKSVNFLHSNK-LTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGS 182 Query: 296 CKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 D T T Y APEV+ + + D W +G ++ E G F D + Sbjct: 183 A---TYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSK 239 Query: 356 K---LFELILM------------------EEIRFPRTLG--------------------- 373 + + E IL + + + Sbjct: 240 EHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDV 299 Query: 374 --PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 L+ +L+ DP +R+ +E ++H FF Sbjct: 300 EHERLFDLIQKMLEYDPAKRI-----TLREALKHPFF 331 >5C26-A nrPDB Length = 299 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 58/253 (22%), Positives = 95/253 (37%), Gaps = 8/253 (3%) Query: 154 KLLGKGTFGKVILVK-EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 K LG G FG V + + K L E V+Q +P++ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272 + + VME A G L +L + R + ++ + YL E N V+ Sbjct: 93 MIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL-EESNFVH 150 Query: 273 RDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE---YLAPEVLEDNDYGRA 329 RDL N++L + KI+DFGL K D K + APE + + Sbjct: 151 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 210 Query: 330 VDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPEAKSLLSGLLKKD 387 D W GV+M+E G+ P+ ++ ++ E + P E L++ D Sbjct: 211 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 270 Query: 388 PKQRLGGGSEDAK 400 + R G + + + Sbjct: 271 VENRPGFAAVELR 283 >5VD3-A nrPDB Length = 311 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 76/260 (29%), Positives = 119/260 (45%), Gaps = 10/260 (3%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS-RHP 208 F+ L LG G++G+V V+ K GR YA+K + A L E + +HP Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-SMSPFRGPKDRARKLAEVGSHEKVGQHP 117 Query: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYLHSE 267 L+ +++ L E G L H E + Y + + AL +LHS+ Sbjct: 118 CCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 +V+ D+K N+ L G K+ DFGL E GA + G P Y+APE+L+ YG Sbjct: 177 -GLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAG-EVQEGDPRYMAPELLQG-SYG 233 Query: 328 RAVDWWGLGVVMYEMMCG-RLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386 A D + LG+ + E+ C LP + ++L + L E L E +S+L +L+ Sbjct: 234 TAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFT--AGLSSELRSVLVMMLEP 291 Query: 387 DPKQRLGGGSEDAKEIMQHR 406 DPK R + A +++ Sbjct: 292 DPKLRATAEALLALPVLRQP 311 >6J5U-C nrPDB Length = 426 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 78/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%) Query: 148 NEFEYLKLLGKGTFGKVIL---------VKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 F LLG+G FG V +G A+K LK E E LTE Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKE---WLTE 140 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAE 256 L HP L L + V E+ G L HL R + + Sbjct: 141 VNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVG 200 Query: 257 IVSALDYLHSEKN-VVYRDLKLENLMLDKDGHIKITDFGLCKEG-IKDGATMKTFC-GTP 313 L +LH K+ V+YRD K N++LD D + K++DFGL K G D + T GT Sbjct: 201 AAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR------------------LPFYNQDHE 355 Y APE + D + GVV+ E++ GR P+ D Sbjct: 261 GYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLG-DKR 319 Query: 356 KLFELILMEEI--RFPRTLGPEAKSLLSGLLKKDPKQR--LGGGSEDAKEI 402 KLF I+ ++ ++P+ A +L L D K R + +++ Sbjct: 320 KLFR-IMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVLVTLEQL 369 >2PMN-X nrPDB Length = 348 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 66/316 (20%), Positives = 135/316 (42%), Gaps = 53/316 (16%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV-------------- 192 +N++ ++ L +G F K+IL + ++YA+K +K ++ K + Sbjct: 30 INDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 193 AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL------FFHLSRE--RV 244 E +++ + ++ + + +D + + EY + FF L + Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 304 + ++++ Y+H+EKN+ +RD+K N+++DK+G +K++DFG + + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVD--K 205 Query: 305 TMKTFCGTPEYLAPEVLEDNDY--GRAVDWWGLGVVMYEMMCGRLPFY-NQDHEKLFELI 361 +K GT E++ PE + G VD W LG+ +Y M +PF +LF I Sbjct: 206 KIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNI 265 Query: 362 LMEEIRFP-------------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 402 + I +P L E L L+K+P +R+ +++ Sbjct: 266 RTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERI-----TSEDA 320 Query: 403 MQHRFFAGIVWQHVYE 418 ++H + A + + E Sbjct: 321 LKHEWLADTNIEDLRE 336 >2WO6-A nrPDB Length = 382 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 68/251 (27%), Positives = 116/251 (46%), Gaps = 22/251 (8%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NS 205 M+ +E L+GKG+FG+V+ ++ + A+KI+K + K + E R+L+ + Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK----KAFLNQAQIEVRLLELMN 108 Query: 206 RHP-----FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIV 258 +H ++ LK F + LC V E + L+ L R S + R + ++ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 259 SALDYLHS-EKNVVYRDLKLENLML--DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEY 315 +AL +L + E ++++ DLK EN++L K IKI DFG + G + + + Y Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL---GQRIYQYIQSRFY 224 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL--- 372 +PEVL Y A+D W LG ++ EM G F + I+ P + Sbjct: 225 RSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ 284 Query: 373 GPEAKSLLSGL 383 P+A+ L Sbjct: 285 APKARKFFEKL 295 Score = 37.6 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 16/35 (45%), Gaps = 5/35 (14%) Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + K L+ +L DPK R+ +QH FF Sbjct: 348 KFKDLILRMLDYDPKTRIQPYY-----ALQHSFFK 377 >4G3E-A nrPDB Length = 352 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 121/306 (39%), Gaps = 33/306 (10%) Query: 118 MDFRSGSPS-DNSGAEEMEVSLAKPKHRVTMNEFEYLKLL---------GKGTFGKVILV 167 + SGS G E + ++ ++EY + + G+G+FG+V + Sbjct: 34 KTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRM 93 Query: 168 KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVM 227 K+K TG A+K ++ EV + E P + L + + + M Sbjct: 94 KDKQTGFQCAVKKVRLEVFR--------VEELVACAGLSSPRIVPLYGAVREGPWVNIFM 145 Query: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG- 286 E GG L + + EDRA +Y + + L+YLH+ + +++ D+K +N++L DG Sbjct: 146 ELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRR-ILHGDVKADNVLLSSDGS 204 Query: 287 HIKITDFGLCKEGIKDG-----ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYE 341 + DFG DG T GT ++APEV+ VD W +M Sbjct: 205 RAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLH 264 Query: 342 MMCGRLPFYNQDHEKLFELILM---EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSED 398 M+ G P+ L I P + P + L+K+P R Sbjct: 265 MLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHR-----AS 319 Query: 399 AKEIMQ 404 A E+ + Sbjct: 320 AMELRR 325 >3ZZW-A nrPDB Length = 289 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 104/274 (37%), Gaps = 28/274 (10%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVK--EKATGRY---YAMKILKKEVIVAKDEVAHTLT 197 ++++ +++ LG+ FGKV A G A+K LK + E Sbjct: 4 KEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLRE--EFRH 61 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV------------- 244 E + +HP + L L + Y + G+L L Sbjct: 62 EAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTV 121 Query: 245 ---FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 A+I + ++YL S +VV++DL N+++ ++KI+D GL +E Sbjct: 122 KSALEPPDFVHLVAQIAAGMEYL-SSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYA 180 Query: 302 DGAT--MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLF 358 + ++APE + + D W GVV++E+ G P+ ++ + Sbjct: 181 ADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVV 240 Query: 359 ELILMEE-IRFPRTLGPEAKSLLSGLLKKDPKQR 391 E+I + + P +L+ + P +R Sbjct: 241 EMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRR 274 >6FYV-A nrPDB Length = 337 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 116/337 (34%), Gaps = 86/337 (25%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKA-TGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 V +E + LG+G FGKV+ + G + A+KI+K +E +VL Sbjct: 10 DVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRY----REAARSEIQVL 65 Query: 203 QNSRH--PF----LTALKYSFQTHDRLCFVMEYANGGELFFHLSRER--VFSEDRARFYG 254 ++ P + F H +C V E G + + F D R Sbjct: 66 EHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMA 124 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDK-------------------DGHIKITDFGL 295 +I ++++LH K + + DLK EN++ K + IK+ DFG Sbjct: 125 YQICQSINFLHHNK-LTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGS 183 Query: 296 CKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355 D T T Y APEV+ + + D W +G ++ E G F D + Sbjct: 184 A---TYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSK 240 Query: 356 K---LFELILME------------------EIRFPRTLG--------------------- 373 + + E IL ++ + Sbjct: 241 EHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDE 300 Query: 374 --PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + L+ +L+ DP QR+ E +QH FF Sbjct: 301 EHEKLFDLVRRMLEYDPTQRI-----TLDEALQHPFF 332 >6O6Q-A nrPDB Length = 335 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 71/346 (20%), Positives = 135/346 (39%), Gaps = 68/346 (19%) Query: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNE----------FEYLKLLGKGTFGKVILV 167 M + + +V KP+ ++ +E L+ LG+G + +V L Sbjct: 1 MSSHRHNTVQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLG 60 Query: 168 KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS-RHPFLTALKYSFQTH--DRLC 224 + +K+LK + E +L+N P + A+ + Sbjct: 61 IDLEKREKVVIKVLK------PVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPG 114 Query: 225 FVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 + E+ N + S F++ RFY E++ ALDY HS +++RD+K N+M+D Sbjct: 115 LIFEHINNID---FRSLYPTFTDYDIRFYMYELLKALDYSHS-MGIMHRDVKPHNVMIDH 170 Query: 285 DGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-EDNDYGRAVDWWGLGVVMYEM 342 D +++ D+GL E G + + PE+L + Y ++D W G ++ M Sbjct: 171 DKKLLRLIDWGLA-EYYHPGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASM 229 Query: 343 MCGRLPFYN--QDHEKLFELILM----------EEIRFP--------------------- 369 + + PF++ + ++L +++ + E+ Sbjct: 230 VFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMN 289 Query: 370 ----RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 + E L+ LL+ D ++RL AKE M+H +F I Sbjct: 290 ENNKDLVSQEFLDLIDRLLRYDHQERL-----TAKEAMKHAYFDPI 330 >4C59-A nrPDB Length = 340 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 119/306 (38%), Gaps = 45/306 (14%) Query: 125 PSDNSGAEEMEVS-LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKK 183 P GA + S + ++L +G F V ++ +GR YA+K L Sbjct: 3 PGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL-- 60 Query: 184 EVIVAKDEVAHTLTENRVLQNSR-HPFLTAL--------KYSFQTHDRLCFVMEYANGGE 234 + +++ + E ++ HP + + S + E G+ Sbjct: 61 -LSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELC-KGQ 118 Query: 235 LFFHLSR---ERVFSEDRARFYGAEIVSALDYLHSEKN-VVYRDLKLENLMLDKDGHIKI 290 L L + S D + A+ ++H +K +++RDLK+ENL+L G IK+ Sbjct: 119 LVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKL 178 Query: 291 TDFGLC---------------KEGIKDGATMKTFCGTPEYLAPEVL---EDNDYGRAVDW 332 DFG + +++ T T TP Y PE++ + G D Sbjct: 179 CDFGSATTISHYPDYSWSAQRRALVEEEITRNT---TPMYRTPEIIDLYSNFPIGEKQDI 235 Query: 333 WGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGP--EAKSLLSGLLKKDPKQ 390 W LG ++Y + + PF +D KL I+ + P SL+ +L+ +P++ Sbjct: 236 WALGCILYLLCFRQHPF--EDGAKL--RIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEE 291 Query: 391 RLGGGS 396 RL Sbjct: 292 RLSIAE 297 >3UIM-A nrPDB Length = 326 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 96/236 (40%), Gaps = 16/236 (6%) Query: 127 DNSGAEEMEVSLAKPKH------RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180 D E+ EV L + K +V + F +LG+G FGKV + A G A+K Sbjct: 3 DVPAEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKR 61 Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGE----LF 236 LK+E + TE ++ + H L L+ T V Y G L Sbjct: 62 LKEERTQGGE--LQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLR 119 Query: 237 FHLSRERVFSEDRARFYGAEIVSALDYLHSE--KNVVYRDLKLENLMLDKDGHIKITDFG 294 + + + L YLH +++RD+K N++LD++ + DFG Sbjct: 120 ERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFG 179 Query: 295 LCKEGIKDGATMKTFC-GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349 L K + T GT ++APE L D +G GV++ E++ G+ F Sbjct: 180 LAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >2H34-A nrPDB Length = 309 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 57/258 (22%), Positives = 106/258 (41%), Gaps = 7/258 (2%) Query: 139 AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 198 A+ + + +L+G+G G V ++ R A+K++ + + E Sbjct: 25 AESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQRE 84 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258 R + P + + + +L M NG +L L R+ + RA +I Sbjct: 85 ARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIG 144 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT-MKTFCGTPEYLA 317 SALD +RD+K EN+++ D + DFG+ + T + GT Y+A Sbjct: 145 SALDAA-HAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMA 203 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAK 377 PE ++ D + L V+YE + G P+ D + + + I P T+ P Sbjct: 204 PERFSESHATYRADIYALTCVLYECLTGSPPYQG-DQLSVMGAHINQAIPRPSTVRPGIP 262 Query: 378 ----SLLSGLLKKDPKQR 391 ++++ + K+P+ R Sbjct: 263 VAFDAVIARGMAKNPEDR 280 >3LMG-A nrPDB Length = 344 Score = 182 bits (461), Expect = 4e-46, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 98/264 (37%), Gaps = 18/264 (6%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRY----YAMKILKKEVIVAKDEVAHTLTENRVLQ 203 E LK+LG G FG V G +K++ E + + Sbjct: 31 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVI--EDKSGRQSFQAVTDHMLAIG 88 Query: 204 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALD 262 + H + L L V +Y G L H+ + R +G +I + Sbjct: 89 SLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMY 147 Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM-KTFCGTP-EYLAPEV 320 YL E +V+R+L N++L +++ DFG+ D + + TP +++A E Sbjct: 148 YL-EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 206 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE-IRFPRTLGPEAKS 378 + Y D W GV ++E+M G P+ ++ +L+ E + P+ + Sbjct: 207 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 266 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEI 402 ++ D R KE+ Sbjct: 267 VMVKCWMIDENIR-----PTFKEL 285 >3MDY-A nrPDB Length = 337 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 122/297 (41%), Gaps = 54/297 (18%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 R + + +K +GKG +G+V + K + G A+K+ E A E + Sbjct: 32 QRTIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVF------FTTEEASWFRETEIY 83 Query: 203 QN--SRHPFLTALKYS----FQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 Q RH + + + +L + +Y G L+ +L + Sbjct: 84 QTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYL-KSTTLDAKSMLKLAYS 142 Query: 257 IVSALDYLHSE-------KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM--- 306 VS L +LH+E + +RDLK +N+++ K+G I D GL + I D + Sbjct: 143 SVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 202 Query: 307 -KTFCGTPEYLAPEVL---EDNDYGRA---VDWWGLGVVMYEMMCG----------RLPF 349 T GT Y+ PEVL + ++ ++ D + G++++E+ +LP+ Sbjct: 203 PNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPY 262 Query: 350 Y-----NQDHEKLFELILMEEIR--FPRTLGPE-----AKSLLSGLLKKDPKQRLGG 394 + + +E + E++ ++++R FP + L++ +P RL Sbjct: 263 HDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA 319 >3Q4U-A nrPDB Length = 301 Score = 180 bits (458), Expect = 9e-46, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 111/297 (37%), Gaps = 54/297 (18%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 R + L+ +GKG +G+V + G A+KI + + E + Sbjct: 3 QRTVARDITLLECVGKGRYGEVW--RGSWQGENVAVKIF------SSRDEKSWFRETELY 54 Query: 203 Q--NSRHPFLTALKYS----FQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 RH + S + +L + Y G L+ +L + + R Sbjct: 55 NTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLR-IVLS 113 Query: 257 IVSALDYLHSE-------KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT- 308 I S L +LH E + +RDLK +N+++ K+G I D GL + + Sbjct: 114 IASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVG 173 Query: 309 ---FCGTPEYLAPEVLEDN------DYGRAVDWWGLGVVMYEMMCG----------RLPF 349 GT Y+APEVL++ D + VD W G+V++E+ + PF Sbjct: 174 NNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPF 233 Query: 350 Y-----NQDHEKLFELILMEEIR-------FPRTLGPEAKSLLSGLLKKDPKQRLGG 394 Y + E + +++ +++ R F L+ ++P RL Sbjct: 234 YDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTA 290 >5AR8-A nrPDB Length = 326 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 60/262 (22%), Positives = 106/262 (40%), Gaps = 21/262 (8%) Query: 153 LKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 L+ L +G G V + A+K L + E L E +L +R ++ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS---EDRARFYGAEIVSALDYLHSE-K 268 + + L V EY G L L R+ + EI ++YLH+ Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-----GTPEYLAPEVLED 323 +++ DLK +N++LD + H+KI DFGL K + + ++ GT Y+ PE E Sbjct: 157 PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 216 Query: 324 NDYGRAV---DWWGLGVVMYEMMCGRLPFYN-QDHEKLFELILME------EIRFPRTLG 373 RA D + V+ +E++ + PF + + ++ + E P + Sbjct: 217 GQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIP 276 Query: 374 PEAK--SLLSGLLKKDPKQRLG 393 A+ SL+ ++P +R Sbjct: 277 HRARMISLIESGWAQNPDERPS 298 >2RIO-A nrPDB Length = 434 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 79/325 (24%), Positives = 141/325 (43%), Gaps = 60/325 (18%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTA 212 K+LG G+ G V+ + GR A+K + + L E ++L S HP + Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDI------ALMEIKLLTESDDHPNVIR 73 Query: 213 LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRAR-------FYGAEIVSALDYLH 265 S T L +E N L + + V E+ +I S + +LH Sbjct: 74 YYCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLH 132 Query: 266 SEKNVVYRDLKLENLMLD-------------KDGHIKITDFGLCKEGIKDGATMKT---- 308 S K +++RDLK +N+++ ++ I I+DFGLCK+ ++ +T Sbjct: 133 SLK-IIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNN 191 Query: 309 FCGTPEYLAPEVLED-------NDYGRAVDWWGLGVVMYEMMC-GRLPF---YNQDHEKL 357 GT + APE+LE+ R++D + +G V Y ++ G+ PF Y+++ + Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNII 251 Query: 358 FELILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQH 415 + ++E++ R+L EA L+S ++ DP +R A ++++H F Sbjct: 252 RGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKR-----PTAMKVLRHPLF------W 300 Query: 416 VYEKKLSPPFKPQVTSETDTRYFDE 440 KKL F +V+ + D Sbjct: 301 PKSKKLE--FLLKVSDRLEIENRDP 323 >6DC0-A nrPDB Length = 292 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 59/238 (24%), Positives = 103/238 (43%), Gaps = 11/238 (4%) Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 H +T + + E + G++ ++ + E+ A +IVSA+ + H Sbjct: 57 HSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCH- 114 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA--TMKTFCGTPEYLAPEVLEDN 324 + +V DLKL + + ++ L I G + G P Y++PE+L Sbjct: 115 QSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTT 174 Query: 325 D--YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 G+A D W LGV++Y ++ GR PF++ D LF I + P + P+A+ L+ Sbjct: 175 GTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRS 234 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440 LL+++P +RL A EI+ H +F ++ TS + Y D Sbjct: 235 LLRREPSERL-----TAPEILLHPWFESVLEGSGSSGGPGGGICEHETSIDISAYIDP 287 >5CEK-A nrPDB Length = 263 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 55/209 (26%), Positives = 97/209 (46%), Gaps = 11/209 (5%) Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 H +T + + E + G++ ++ + E+ A +IVSA+ + H Sbjct: 60 HSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCH- 117 Query: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA--TMKTFCGTPEYLAPEVLEDN 324 + +V DLKL + + ++ L I G + G P Y++PE+L Sbjct: 118 QSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTT 177 Query: 325 D--YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382 G+A D W LGV++Y ++ GR PF++ D LF I + P + P+A+ L+ Sbjct: 178 GTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRS 237 Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 LL+++P +RL A EI+ H +F + Sbjct: 238 LLRREPSERL-----TAPEILLHPWFESV 261 >5TE0-A nrPDB Length = 347 Score = 175 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 124/306 (40%), Gaps = 49/306 (16%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + +VT++ ++L +G F V LV+ + G A+K + + + ++ E ++ Sbjct: 18 RQQVTVD-----EVLAEGGFAIVFLVR-TSNGMKCALKRM---FVNNEHDLQVCKREIQI 68 Query: 202 LQNSR-HPFLTALKYSFQTH------DRLCFVMEYANGGELFFHLSRE--RVFSEDRARF 252 +++ H + S + + +M++ GG++ +++ F+E+ Sbjct: 69 MRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQ 128 Query: 253 YGAEIVSALDYLHSEK-NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG 311 + A+ LH K +++RDLK+EN++L GH + DFG ++ T Sbjct: 129 IFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAV 188 Query: 312 --------TPEYLAPEVLE---DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360 T Y APE++ D W LG ++Y++ LPF + + + Sbjct: 189 EDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GESQVAICD- 246 Query: 361 ILMEEIRFPRT--LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 418 P + L+ +L+ DP +R +I Q +F+ + + Sbjct: 247 ---GNFTIPDNSRYSQDMHCLIRYMLEPDPDKR--------PDIYQVSYFS----FKLLK 291 Query: 419 KKLSPP 424 K+ P Sbjct: 292 KECPIP 297 >4MD7-E nrPDB Length = 391 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 71/355 (20%), Positives = 130/355 (36%), Gaps = 69/355 (19%) Query: 123 GSPSDNSGAEEMEVSLAKPKHRVTM----------NEFEYLKLLGKGTFGKVILVKEKAT 172 P + +V+ +P+ ++++ ++ LG+G + +V Sbjct: 2 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 61 Query: 173 GRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTH--DRLCFVMEY 229 I+ + E ++L+N R P + L + V E+ Sbjct: 62 NEK------VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 115 Query: 230 ANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-I 288 N + + ++ RFY EI+ ALDY HS +++RD+K N+M+D + + Sbjct: 116 VNNTD---FKQLYQTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKL 171 Query: 289 KITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-EDNDYGRAVDWWGLGVVMYEMMCGRL 347 ++ D+GL E G + + PE+L + Y ++D W LG ++ M+ + Sbjct: 172 RLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKE 230 Query: 348 PFYNQDH--------------EKLFELILMEEIRFPRT---------------------- 371 PF++ E L++ I I Sbjct: 231 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 290 Query: 372 --LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPP 424 + PEA L LL+ D + RL A+E M+H +F +V S P Sbjct: 291 HLVSPEALDFLDKLLRYDHQSRL-----TAREAMEHPYFYTVVKDQARMGSSSMP 340 >6HMD-A nrPDB Length = 365 Score = 174 bits (441), Expect = 9e-44, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 124/308 (40%), Gaps = 59/308 (19%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 ++++ ++ LG+G + +V I+ + E ++L+N R Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNER------VVVKILKPVKKKKIKREVKILENLRG 106 Query: 208 P-FLTALKYSFQTH--DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 + L + + V EY N + ++ ++ RFY E++ ALDY Sbjct: 107 GTNIIKLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYC 163 Query: 265 HSEKNVVYRDLKLENLMLDK-DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-E 322 HS K +++RD+K N+M+D +++ D+GL E + + PE+L + Sbjct: 164 HS-KGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 221 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFY-NQDH-------------EKLFELILMEEIRF 368 Y ++D W LG ++ M+ R PF+ QD+ E+L+ + I Sbjct: 222 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 281 Query: 369 PRT------------------------LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 + PEA LL LL+ D +QRL AKE M+ Sbjct: 282 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKEAME 336 Query: 405 HRFFAGIV 412 H +F +V Sbjct: 337 HPYFYPVV 344 >4CRL-A nrPDB Length = 406 Score = 173 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 72/351 (20%), Positives = 139/351 (39%), Gaps = 82/351 (23%) Query: 127 DNSGAEEMEVSLAKPKHRV-TMNEFEYLKLLGKGTFGKVILVKEKATGRY--YAMKILKK 183 D+ + +V L+ + RV + E+E K+ G+GT+G V K K YA+K ++ Sbjct: 1 DDKMDYDFKVKLSSERERVEDLFEYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEG 59 Query: 184 EVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTH--DRLCFVMEYANGGELFFHLSR 241 I E +L+ +HP + +L+ F +H ++ + +YA +L+ + Sbjct: 60 TGISM-----SACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKF 113 Query: 242 ERV---------FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD----KDGHI 288 R + +I+ + YLH+ V++RDLK N+++ + G + Sbjct: 114 HRASKANKKPVQLPRGMVKSLLYQILDGIHYLHAN-WVLHRDLKPANILVMGEGPERGRV 172 Query: 289 KITDFGLCKEGIKDGATMKTF---CGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMC 344 KI D G + + T Y APE+L Y +A+D W +G + E++ Sbjct: 173 KIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT 232 Query: 345 GRL-------------PFYNQDHEKLFELIL-------MEEIRFPRT------------- 371 P+++ +++F ++ + + P Sbjct: 233 SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT 292 Query: 372 ------------LGPEAK--SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 + P++K LL LL DP +R+ +++ MQ +F Sbjct: 293 NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRI-----TSEQAMQDPYF 338 >5L2Q-C nrPDB Length = 320 Score = 173 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 77/281 (27%), Positives = 127/281 (45%), Gaps = 47/281 (16%) Query: 165 ILVKEKATGRYYAMKILKKEV-----IVAKDEVAHTL---TENRVLQNSR-HPFLTALKY 215 L ++ T +Y +KIL E I +++E + TE +L + Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 216 SFQT------------------HDRLCFVME-YANGG---------ELFFHLSRERVFSE 247 FQ R+C V++ L ++ +E+ SE Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 248 DRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATM 306 ++V ++ LH +KN+V+RDLKL N++L+K H I IT+F L K + +G + Sbjct: 153 RETVVIFYDVVRVVEALH-QKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLL 211 Query: 307 KTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEE 365 K G+P Y++P+VL Y G+ D W LGVV++ M+ G+ PFY+ ++LF I E Sbjct: 212 KDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAE 271 Query: 366 IRFPRT--LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 P + L+ LL DP+QRL A ++++ Sbjct: 272 YTIPEDGRVSENTVCLIRKLLVLDPQQRLA-----AADVLE 307 >3RAW-A nrPDB Length = 381 Score = 173 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 79/378 (20%), Positives = 127/378 (33%), Gaps = 98/378 (25%) Query: 115 EEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTM------NEFEYLKLLGKGTFGKVILVK 168 E + +S V K H V +E + LG+GTFGKV+ Sbjct: 14 GTENLYFQS--MQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECL 71 Query: 169 EKATGR-YYAMKILKKEVIVAKDEVAHTLTENRVLQNS---RHPF---LTALKYSFQTHD 221 + A G+ A+KI++ + E A E VL+ + F H Sbjct: 72 DHARGKSQVALKIIRN--VGKYREAARL--EINVLKKIKEKDKENKFLCVLMSDWFNFHG 127 Query: 222 RLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLEN 279 +C E F L + + R ++ AL +LH E + + DLK EN Sbjct: 128 HMCIAFELLGKNT-FEFLKENNFQPYPLPHVRHMAYQLCHALRFLH-ENQLTHTDLKPEN 185 Query: 280 LMLD-------------------KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320 ++ K+ I++ DFG D T T Y PEV Sbjct: 186 ILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF---DHEHHTTIVATRHYRPPEV 242 Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----------- 369 + + + + D W +G +++E G F ++ + L++ME+I P Sbjct: 243 ILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENRE--HLVMMEKILGPIPSHMIHRTRK 300 Query: 370 ------------------RTLGPEAK-----------------SLLSGLLKKDPKQRLGG 394 R + K L+ +L+ DP QR+ Sbjct: 301 QKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRI-- 358 Query: 395 GSEDAKEIMQHRFFAGIV 412 E + H FFAG+ Sbjct: 359 ---TLAEALLHPFFAGLT 373 >2PVN-A nrPDB Length = 352 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 115/306 (37%), Gaps = 57/306 (18%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 +++E ++ +G+G + +V +++ + + Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNE-----KCIIKILKPVKKKKIKREIKILQNLCGG 106 Query: 208 PFLTALKYSF--QTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 P + L Q + EY N + F L ++ R+Y E++ ALDY H Sbjct: 107 PNIVKLLDIVRDQHSKTPSLIFEYVNNTD-FKVLY--PTLTDYDIRYYIYELLKALDYCH 163 Query: 266 SEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED- 323 S+ +++RD+K N+M+D + +++ D+GL E G + + PE+L D Sbjct: 164 SQ-GIMHRDVKPHNVMIDHELRKLRLIDWGLA-EFYHPGKEYNVRVASRYFKGPELLVDL 221 Query: 324 NDYGRAVDWWGLGVVMYEMMCGRLP-FYNQDHEKLFELILM-----------EEIRF--- 368 DY ++D W LG + M+ + P FY D+ I + R Sbjct: 222 QDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELD 281 Query: 369 PR-----------------------TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 P+ + PEA L LL+ D ++RL A E M H Sbjct: 282 PQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERL-----TALEAMTH 336 Query: 406 RFFAGI 411 +F + Sbjct: 337 PYFQQV 342 >4JLC-A nrPDB Length = 657 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 60/234 (25%), Positives = 100/234 (42%), Gaps = 27/234 (11%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG YA+K+ + +V + E VL+ H + L Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 72 Query: 215 YSFQTHD---RLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVSALDYLHSEK 268 + + +ME+ G L+ L E ++V +++L E Sbjct: 73 -AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL-REN 130 Query: 269 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 +V+RD+K N+M + +DG K+TDFG +E D + + GT EYL P++ E Sbjct: 131 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYERA 189 Query: 323 ------DNDYGRAVDWWGLGVVMYEMMCGRLPFY----NQDHEKLFELILMEEI 366 YG VD W +GV Y G LPF + ++++ I+ + Sbjct: 190 VLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 243 >2QKW-B nrPDB Length = 321 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 63/242 (26%), Positives = 102/242 (42%), Gaps = 13/242 (5%) Query: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168 G K + + S S E V L + N F++ L+G G FGKV Sbjct: 2 GSKYSKATNSINDALSSSYLVPFESYRVPLVDLEE--ATNNFDHKFLIGHGVFGKVYKGV 59 Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVME 228 + G A+K + + + TE L RHP L +L + + + + Sbjct: 60 LR-DGAKVALK---RRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCDERNEMILIYK 115 Query: 229 YANGGELFFHLSRERV----FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284 Y G L HL + S ++ L YLH+ + +++RD+K N++LD+ Sbjct: 116 YMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHT-RAIIHRDVKSINILLDE 174 Query: 285 DGHIKITDFGLCKEGIKDGATMKTFC--GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342 + KITDFG+ K+G + T + GT Y+ PE D + GVV++E+ Sbjct: 175 NFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEV 234 Query: 343 MC 344 +C Sbjct: 235 LC 236 >3MY0-A nrPDB Length = 305 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 57/297 (19%), Positives = 102/297 (34%), Gaps = 54/297 (18%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 R + ++ +GKG +G+V G A+KI + + E + Sbjct: 3 QRTVARQVALVECVGKGRYGEVWRGLWH--GESVAVKIF------SSRDEQSWFRETEIY 54 Query: 203 QN--SRHPFLTALKYSFQTH----DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 RH + S T +L + Y G L+ L R + A Sbjct: 55 NTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQR-QTLEPHLALRLAVS 113 Query: 257 IVSALDYLHSE-------KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM--- 306 L +LH E + +RD K N+++ + I D GL + + Sbjct: 114 AACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG 173 Query: 307 -KTFCGTPEYLAPEVLEDN------DYGRAVDWWGLGVVMYEMMCG----------RLPF 349 GT Y+APEVL++ + + D W G+V++E+ R PF Sbjct: 174 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPF 233 Query: 350 Y-----NQDHEKLFELILMEE--IRFPRTLGPE-----AKSLLSGLLKKDPKQRLGG 394 Y + E + +++ +++ P L + ++ +P RL Sbjct: 234 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA 290 >1PY5-A nrPDB Length = 326 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 116/297 (39%), Gaps = 54/297 (18%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 R + +GKG FG+V K + G A+KI + E E + Sbjct: 24 QRTIARTIVLQESIGKGRFGEVWRGKWR--GEEVAVKIF------SSREERSWFREAEIY 75 Query: 203 Q--NSRHPFLTALKYSFQTHD----RLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256 Q RH + + + +L V +Y G LF +L+R V E + Sbjct: 76 QTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIK-LALS 134 Query: 257 IVSALDYLHSE-------KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM--- 306 S L +LH E + +RDLK +N+++ K+G I D GL T+ Sbjct: 135 TASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIA 194 Query: 307 -KTFCGTPEYLAPEVLEDN------DYGRAVDWWGLGVVMYEMMCG----------RLPF 349 GT Y+APEVL+D+ + + D + +G+V +E+ +LP+ Sbjct: 195 PNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPY 254 Query: 350 Y-----NQDHEKLFELILMEEIR--FP-RTLGPEA----KSLLSGLLKKDPKQRLGG 394 Y + E++ +++ +++R P R EA ++ + RL Sbjct: 255 YDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTA 311 >4EUU-A nrPDB Length = 319 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 100/234 (42%), Gaps = 27/234 (11%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 73 Query: 215 YSFQTHD---RLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVSALDYLHSEK 268 + + +ME+ G L+ L E ++V +++L E Sbjct: 74 -AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL-REN 131 Query: 269 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 +V+R++K N+M + +DG K+TDFG +E D + + GT EYL P++ E Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYERA 190 Query: 323 ------DNDYGRAVDWWGLGVVMYEMMCGRLPFY----NQDHEKLFELILMEEI 366 YG VD W +GV Y G LPF + ++++ I+ + Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 >5XD6-A nrPDB Length = 305 Score = 172 bits (435), Expect = 5e-43, Method: Composition-based stats. Identities = 55/214 (25%), Positives = 86/214 (40%), Gaps = 18/214 (8%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + + L+G+G++G+V K +G+ A+K L +K L + ++ R Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLD----SSKQPDQEFLAQVSMVSRLRQ 76 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER---------VFSEDRARFYGAEIV 258 + AL EYA G L L + V S + Sbjct: 77 ENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAA 136 Query: 259 SALDYLHSEKN--VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC--GTPE 314 L+YLH + N V++RD+K N++L D KI DF L + A + + GT Sbjct: 137 RGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFG 196 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP 348 Y APE D + GVV+ E++ GR P Sbjct: 197 YHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >5UNP-A nrPDB Length = 369 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 74/355 (20%), Positives = 124/355 (34%), Gaps = 86/355 (24%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK-EKATGRYYAMKILKKEVIV 187 S ++ E L +E + LG+GTFG+V+ + G A+KI+K + Sbjct: 15 SVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKN--VE 72 Query: 188 AKDEVAHTLTENRVLQNS-----RHPFL-TALKYSFQTHDRLCFVMEYANGGELFFHLSR 241 E A E VL+ + L + F H +C E G F L Sbjct: 73 KYKEAARL--EINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKD 129 Query: 242 ERVFSED--RARFYGAEIVSALDYLHSEKNVVYRDLKLENLM-LDKDGH----------- 287 + R ++ A+ +LH K + + DLK EN++ ++ D Sbjct: 130 NNYLPYPIHQVRHMAFQLCQAVKFLHDNK-LTHTDLKPENILFVNSDYELTYNLEKKRDE 188 Query: 288 -------IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMY 340 +++ DFG D T T Y APEV+ + + + D W +G +++ Sbjct: 189 RSVKSTAVRVVDFGSATF---DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIF 245 Query: 341 EMMCGRLPFYNQDHEK---------------LFELILMEEI------------------- 366 E G F D+ + + ++ Sbjct: 246 EYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVR 305 Query: 367 ----RFPRTLGPEAK------SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 R L EA+ L+ +L+ +P +RL G E +QH FFA + Sbjct: 306 ENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLG-----EALQHPFFARL 355 >6EII-A nrPDB Length = 352 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 120/308 (38%), Gaps = 59/308 (19%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR- 206 ++++ ++ LG+G + +V I+ + E ++L+N R Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLRG 113 Query: 207 HPFLTALKYSFQTH--DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 P + L + V E+ N + + ++ RFY EI+ ALDY Sbjct: 114 GPNIITLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDYC 170 Query: 265 HSEKNVVYRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-E 322 HS +++RD+K N+M+D + +++ D+GL E G + + PE+L + Sbjct: 171 HS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 228 Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH--------------EKLFELILMEEIRF 368 Y ++D W LG ++ M+ + PF++ E L++ I I Sbjct: 229 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 288 Query: 369 PRT------------------------LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 + PEA L LL+ D + RL A+E M+ Sbjct: 289 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAME 343 Query: 405 HRFFAGIV 412 H +F +V Sbjct: 344 HPYFYTVV 351 >5XVU-A nrPDB Length = 332 Score = 171 bits (434), Expect = 6e-43, Method: Composition-based stats. Identities = 69/332 (20%), Positives = 126/332 (37%), Gaps = 65/332 (19%) Query: 123 GSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK 182 P + + +E+ KP N +E +K +G+G + +V + R A Sbjct: 12 HKPKEYYDYDNLELQWNKP------NRYEIMKKIGRGKYSEVFNGYDTECNRPCA----- 60 Query: 183 KEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTH--DRLCFVMEYANGGELFFHL 239 ++ + E ++LQN P + L + + EY N + Sbjct: 61 -IKVLKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLY 119 Query: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKE 298 + F++ R+Y +I+ ALDY HS+ +++RD+K N+M+D ++ I++ +GL E Sbjct: 120 PK---FTDKDIRYYIYQILKALDYCHSQ-GIMHRDVKPHNIMIDHENRQIRLISWGLA-E 174 Query: 299 GIKDGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFY-NQDHEK 356 G + Y PE+L D Y ++D W LG ++ M+ + PF+ D+ Sbjct: 175 FYHPGQEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYD 234 Query: 357 LFELILM-----------EEIRF---PRTLG-----------------------PEAKSL 379 I ++ P L E L Sbjct: 235 QLVKIAKVLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDL 294 Query: 380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 + +L D +R+ KE M+H +F + Sbjct: 295 IDKMLIYDHAKRIAP-----KEAMEHPYFREV 321 >5IKW-A nrPDB Length = 310 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 111/294 (37%), Gaps = 44/294 (14%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 A +H+VT+ + L +G F V LV+ G A+K + + ++ Sbjct: 9 FAVGRHQVTLE-----ESLAEGGFSTVFLVRTHG-GIRCALKRMYVNNMP---DLNVCKR 59 Query: 198 ENRVLQNSR-HPFLTALKYSFQTH--DRLC---FVMEYANGGELFFHLSRE--RVFSEDR 249 E +++ H + D + +MEY G++ ++++ F+E Sbjct: 60 EITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPE 119 Query: 250 ARFYGAEIVSALDYLHSEK-NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT 308 + A+ LH K +++RDLK+EN++L+ G+ + DFG + Sbjct: 120 VLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGV 179 Query: 309 FCG--------TPEYLAPEVLE---DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357 T Y APE++ D W LG ++Y++ LPF + + Sbjct: 180 NVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQVAI 238 Query: 358 FELILMEEIRFPRT--LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 409 + P L+ +L+ DP+ R +I Q +FA Sbjct: 239 CD----GNFTIPDNSRYSRNIHCLIRFMLEPDPEHR--------PDIFQVSYFA 280 >2BUJ-A nrPDB Length = 317 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 61/274 (22%), Positives = 112/274 (40%), Gaps = 29/274 (10%) Query: 143 HRVTMNE--FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 200 H V ++ + +++ LG+G F V LV+ G +YA+K + + + + E Sbjct: 22 HMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI---LCHEQQDREEAQREAD 78 Query: 201 VLQNSRHPFLTALKYSFQTH----DRLCFVMEYANGGELFFHLSR----ERVFSEDRARF 252 + + HP + L ++ + G L+ + R +ED+ + Sbjct: 79 MHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILW 138 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG------LCKEGIKDGATM 306 I L+ +H+ K +RDLK N++L +G + D G + EG + T+ Sbjct: 139 LLLGICRGLEAIHA-KGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTL 197 Query: 307 KTFCG---TPEYLAPEVLEDNDY---GRAVDWWGLGVVMYEMMCGRLPFYNQDHE-KLFE 359 + + T Y APE+ + D W LG V+Y MM G P+ + Sbjct: 198 QDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVA 257 Query: 360 LILMEEIRFPRTL--GPEAKSLLSGLLKKDPKQR 391 L + ++ P++ LL+ ++ DP QR Sbjct: 258 LAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQR 291 >4EUT-A nrPDB Length = 396 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 100/234 (42%), Gaps = 27/234 (11%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 73 Query: 215 YSFQTHD---RLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVSALDYLHSEK 268 + + +ME+ G L+ L E ++V +++L E Sbjct: 74 -AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL-REN 131 Query: 269 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 +V+R++K N+M + +DG K+TDFG +E D + + GT EYL P++ E Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYERA 190 Query: 323 ------DNDYGRAVDWWGLGVVMYEMMCGRLPFY----NQDHEKLFELILMEEI 366 YG VD W +GV Y G LPF + ++++ I+ + Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 >4MWI-A nrPDB Length = 294 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 97/253 (38%), Gaps = 19/253 (7%) Query: 166 LVKEKATGRYYAMKILKKEVIVAKDEVAHTL-TENRVLQNSRHPFLTALKYSFQTHD--- 221 L K + A+K+ KK + V T E + ++ P + + Sbjct: 40 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 99 Query: 222 -RLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH-SEKNVVYRDLKLEN 279 + VMEY G L L RE+ + + L LH SE ++ ++ N Sbjct: 100 PQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSN 159 Query: 280 LMLDKDGHIKITDFGLCKE----GIKDGATMKTFCGTPEYLAPEVLED--NDYGRAVDWW 333 ++ + +K+ F L K + + YL+P+ LED Y + + Sbjct: 160 FLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIY 219 Query: 334 GLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP--RTLGPEAKSLLSGLLKKDPKQR 391 G+V++E+ G +PF + EK+ +L+ ++ + P E + ++ DP R Sbjct: 220 SFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVR 279 Query: 392 LGGGSEDAKEIMQ 404 EI++ Sbjct: 280 -----PSVDEILK 287 >6NT9-A nrPDB Length = 742 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 58/233 (24%), Positives = 99/233 (42%), Gaps = 25/233 (10%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 71 Query: 215 YSFQTHD--RLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVSALDYLHSEKN 269 + +ME+ G L+ L E ++V +++L E Sbjct: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL-RENG 130 Query: 270 VVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE--- 322 +V+R++K N+M + +DG K+TDFG +E D + + GT EYL P++ E Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-SLYGTEEYLHPDMYERAV 189 Query: 323 -----DNDYGRAVDWWGLGVVMYEMMCGRLPFY----NQDHEKLFELILMEEI 366 YG VD W +GV Y G LPF + ++++ I+ + Sbjct: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 >6O8B-A nrPDB Length = 665 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 99/234 (42%), Gaps = 27/234 (11%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK 214 +LG+G V + K TG +A+K+ + +V + E VL+ H + L Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLF 79 Query: 215 YSFQTHD---RLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVSALDYLHSEK 268 + + +ME+ G L+ L E ++V +++L E Sbjct: 80 -AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL-REN 137 Query: 269 NVVYRDLKLENLM--LDKDGH--IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-- 322 +V+R++K N+M + +DG K+TDFG +E D + GT EYL P++ E Sbjct: 138 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFV-ELYGTEEYLHPDMYERA 196 Query: 323 ------DNDYGRAVDWWGLGVVMYEMMCGRLPFY----NQDHEKLFELILMEEI 366 YG VD W +GV Y G LPF + ++++ I+ + Sbjct: 197 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 250 >6BFN-A nrPDB Length = 342 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 51/208 (24%), Positives = 82/208 (39%), Gaps = 17/208 (8%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH-TLTENRVLQNSRHPFLTAL 213 +G+G FG V + T YA+K LK+ + V LTE L RHP + Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 214 KYSFQTHDRLCFVMEYANGGELFFHLSRE----RVFSEDRARFYGAEIVSALDYLHSEKN 269 + C V + G L L + S + A+ +LH + Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 270 -VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA---------TMKTFCGTPEYLAPE 319 +++ D+K N++LD+ K+ DFGL + G+ +T GT YL E Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEE 206 Query: 320 VLEDNDYGRAVDWWGLGVVMYEMMCGRL 347 ++ D + GVV+ E + G+ Sbjct: 207 YIKTGRLAVDTDTFSFGVVVLETLAGQR 234 >5VC6-A nrPDB Length = 289 Score = 168 bits (426), Expect = 5e-42, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 116/294 (39%), Gaps = 41/294 (13%) Query: 138 LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 197 K R T EF L+ +G G FG V ++ G YA+K KK + + DE + L Sbjct: 2 AGSMKSRYT-TEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDE-QNALR 59 Query: 198 ENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE----RVFSEDRARF 252 E +H + ++ D + EY NGG L +S F E + Sbjct: 60 EVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKD 119 Query: 253 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI-------------------KITDF 293 ++ L Y+HS ++V+ D+K N+ + + KI D Sbjct: 120 LLLQVGRGLRYIHS-MSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDL 178 Query: 294 GLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYN 351 G + ++ + G +LA EVL++N Y D + L + + G P Sbjct: 179 G----HVTRISSPQVEEGDSRFLANEVLQEN-YTHLPKADIFALALTV-VCAAGAEPLP- 231 Query: 352 QDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 ++ ++ E+ R P+ L E LL ++ DP++R A +++H Sbjct: 232 RNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERR-----PSAMALVKH 280 >2Y4I-B nrPDB Length = 319 Score = 167 bits (424), Expect = 7e-42, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 115/274 (41%), Gaps = 23/274 (8%) Query: 135 EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH 194 + S+ + + + E +L+GKG FG+V + A++++ E +D++ Sbjct: 20 QTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIER-DNEDQLKA 75 Query: 195 TLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFY 253 E + +RH + + + L + G L+ + + V ++ R Sbjct: 76 FKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQI 135 Query: 254 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGL-----CKEGIKDGATMKT 308 EIV + YLH+ K ++++DLK +N+ D +G + ITDFGL + + ++ Sbjct: 136 AQEIVKGMGYLHA-KGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRI 193 Query: 309 FCGTPEYLAPEVLED---------NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 359 G +LAPE++ + + D + LG + YE+ PF Q E + Sbjct: 194 QNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIW 253 Query: 360 LILME-EIRFPRT-LGPEAKSLLSGLLKKDPKQR 391 + + + +G E +L + ++R Sbjct: 254 QMGTGMKPNLSQIGMGKEISDILLFCWAFEQEER 287 >4IAN-A nrPDB Length = 358 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 48/226 (21%), Positives = 95/226 (42%), Gaps = 17/226 (7%) Query: 157 GKGTFGKVILVKEKAT-GRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP------F 209 G+G F V+ ++ A + A+KI++ ++ K L E L+ Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG----LKELEFLKKLNDADPDDKFH 94 Query: 210 LTALKYSFQTHDRLCFVME--YANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 L F LC V E N E+ ++ R Y ++ AL L Sbjct: 95 CLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLL-KR 153 Query: 268 KNVVYRDLKLENLMLDKDGHI-KITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326 N+++ D+K +N+++++ I K+ DFG + + + + Y APE++ Y Sbjct: 154 CNILHADIKPDNILVNESKTILKLCDFGSASHVADND--ITPYLVSRFYRAPEIIIGKSY 211 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL 372 +D W +G +YE+ G++ F + + + +L + + + P + Sbjct: 212 DYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKM 257 >4M66-A nrPDB Length = 325 Score = 164 bits (416), Expect = 7e-41, Method: Composition-based stats. Identities = 63/264 (23%), Positives = 104/264 (39%), Gaps = 33/264 (12%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 V+ E + L+ +GKG FG V + A+KI+ + I E + + N Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW---------EVKAMVN 67 Query: 205 SRHPFLTALKYSFQT--HDRL---CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 R+ + L + D + V + G L L E E+V Sbjct: 68 LRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVL 127 Query: 260 ALDYLHS-EKNVVYRDLKLENLMLDKDGHIKITDFGLCK------EGIKDGATMKTFCGT 312 + YLHS + +++RDLK N++LD + H K+ DFGL G G+ + GT Sbjct: 128 GMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGT 187 Query: 313 PEYLAPEVLE--DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP- 369 YL PE+L + +A D + G++++ ++ GR + E + + R P Sbjct: 188 LAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPL 247 Query: 370 ---RTLGPE------AKSLLSGLL 384 PE K L+ Sbjct: 248 TELPPGSPETPGLEKLKELMIHCW 271 >3REP-A nrPDB Length = 271 Score = 164 bits (415), Expect = 8e-41, Method: Composition-based stats. Identities = 45/260 (17%), Positives = 107/260 (41%), Gaps = 18/260 (6%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 + + +L L + G++ + + G +K+LK + E Sbjct: 4 HSGIDFKQLNFLTKLNENHSGELWKGRWQ--GNDIVVKVLKVRDWSTRK-SRDFNEECPR 60 Query: 202 LQNSRHPFLTALKYSFQTHD--RLCFVMEYANGGELFFHLSRERVF--SEDRARFYGAEI 257 L+ HP + + + Q+ + + G L+ L F + +A + ++ Sbjct: 61 LRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDM 120 Query: 258 VSALDYLHSEKNVVYRD-LKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 316 + +LH+ + ++ R L ++M+D+D +I+ + + + + P ++ Sbjct: 121 ARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---MADVKFSFQSPGRMYA--PAWV 175 Query: 317 APEVLEDNDYG---RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIR--FPRT 371 APE L+ R+ D W V+++E++ +PF + + ++ + +E +R P Sbjct: 176 APEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPG 235 Query: 372 LGPEAKSLLSGLLKKDPKQR 391 + P L+ + +DP +R Sbjct: 236 ISPHVSKLMKICMNEDPAKR 255 >4BTF-A nrPDB Length = 469 Score = 163 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 43/234 (18%), Positives = 89/234 (38%), Gaps = 14/234 (5%) Query: 176 YAMKILKKEVIVAKDEVAHTLT-ENRVLQNSRHPFLTALKYSFQT----HDRLCFVMEYA 230 +K+ + V T E + ++ P + + VMEY Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 280 Query: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290 G L L RE+ + L LH + + +R++ + ++ +K+ Sbjct: 281 ELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETL-HRNISSSSFLVAGGYQVKL 339 Query: 291 TDFGLCKEGIKDGATMKTFCG----TPEYLAPEVLED--NDYGRAVDWWGLGVVMYEMMC 344 F L K T K+ + Y++PE L++ Y + + G+V++E+ Sbjct: 340 AGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT 399 Query: 345 GRLPFYNQDHEKLFELILMEEIRFP--RTLGPEAKSLLSGLLKKDPKQRLGGGS 396 G++PF D +K+ EL+ ++ + P + + +++ +P QR Sbjct: 400 GKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 453 >4M69-B nrPDB Length = 283 Score = 163 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 43/234 (18%), Positives = 89/234 (38%), Gaps = 14/234 (5%) Query: 176 YAMKILKKEVIVAKDEVAHTLT-ENRVLQNSRHPFLTALKYSFQT----HDRLCFVMEYA 230 +K+ + V T E + ++ P + + VMEY Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 94 Query: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290 G L L RE+ + L LH + + +R++ + ++ +K+ Sbjct: 95 ELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETL-HRNISSSSFLVAGGYQVKL 153 Query: 291 TDFGLCKEGIKDGATMKTFCG----TPEYLAPEVLED--NDYGRAVDWWGLGVVMYEMMC 344 F L K T K+ + Y++PE L++ Y + + G+V++E+ Sbjct: 154 AGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT 213 Query: 345 GRLPFYNQDHEKLFELILMEEIRFP--RTLGPEAKSLLSGLLKKDPKQRLGGGS 396 G++PF D +K+ EL+ ++ + P + + +++ +P QR Sbjct: 214 GKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 267 >6HV0-A nrPDB Length = 416 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 83/348 (23%), Positives = 137/348 (39%), Gaps = 50/348 (14%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTAL 213 +LG G G ++ + R A+K + E D E ++L+ S HP + Sbjct: 15 VLGHGAEGTIV-YRGMFDNRDVAVKRILPECFSFAD------REVQLLRESDEHPNVIR- 66 Query: 214 KYSFQTHDRL--CFVMEYANGGELFFHLSRERVFSED-RARFYGAEIVSALDYLHSEKNV 270 Y DR +E L ++ ++ + S L +LHS N+ Sbjct: 67 -YFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHS-LNI 123 Query: 271 VYRDLKLENLML---DKDGHIK--ITDFGLCKE---GIKDGATMKTFCGTPEYLAPEVLE 322 V+RDLK N+++ + G IK I+DFGLCK+ G + GT ++APE+L Sbjct: 124 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 183 Query: 323 D---NDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLGPE--- 375 + + VD + G V Y ++ G PF + IL+ L PE Sbjct: 184 EDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ--ANILLGACSL-DCLHPEKHE 240 Query: 376 ---AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSE 432 A+ L+ ++ DP++R AK +++H FF W EK+L F V+ Sbjct: 241 DVIARELIEKMIAMDPQKR-----PSAKHVLKHPFF----WS--LEKQLQ--FFQDVSDR 287 Query: 433 TDTRYFDEEFTAQMITIT-PPDQDDSMECVDSERRPHFPQFSYSASGT 479 + D Q+ + D E + + +F G+ Sbjct: 288 IEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGS 335 >2JD5-A nrPDB Length = 373 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 66/358 (18%), Positives = 124/358 (34%), Gaps = 88/358 (24%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH- 207 + ++ LG G F V L K+ + AMKI++ + + E ++LQ Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYT----EAAEDEIKLLQRVNDA 75 Query: 208 ----------PFLTALKYSFQTHD----RLCFVMEYANGGELFFHLSR--ERVFSEDRAR 251 + L F + V E G L + + R + Sbjct: 76 DNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFE-VLGENLLALIKKYEHRGIPLIYVK 134 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-----KDG-HIKITDFGLCKEGIKDGAT 305 +++ LDY+H +++ D+K EN++++ ++ IKI D G Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY---DEH 191 Query: 306 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF-------YNQDHEKLF 358 T EY +PEVL +G D W +++E++ G F Y +D + + Sbjct: 192 YTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIA 251 Query: 359 ELI-----------------------------------------LMEEIRFPRTLGPEAK 377 ++I L E+ +F + E Sbjct: 252 QIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEIS 311 Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDT 435 LS +L+ DP++R DA ++ H + + +++ P + S +D Sbjct: 312 DFLSPMLQLDPRKR-----ADAGGLVNHPWLK----DTLGMEEIRVPDRELYGSGSDI 360 >4PL5-B nrPDB Length = 435 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 116/275 (42%), Gaps = 39/275 (14%) Query: 155 LLGKGTFGK-VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTA 212 +LG G G V R A+K + E D E ++L+ S HP + Sbjct: 34 VLGHGAEGTIVYKG--MFDNRDVAVKRILPECFSFAD------REVQLLRESDEHPNVIR 85 Query: 213 LKYSFQTHDRL--CFVMEYANGGELFFHLSRERVFSED-RARFYGAEIVSALDYLHSEKN 269 Y DR +E L ++ ++ + S L +LHS N Sbjct: 86 --YFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHS-LN 141 Query: 270 VVYRDLKLENLML---DKDGHIK--ITDFGLCKE---GIKDGATMKTFCGTPEYLAPEVL 321 +V+RDLK N++L + G IK I+DFGLCK+ G + GT ++APE+L Sbjct: 142 IVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 201 Query: 322 ED---NDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM----EEIRFPRTLG 373 + ++ VD + G V Y ++ G PF + ++ ++L + + Sbjct: 202 SEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNLDCFHSDKHED 260 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 A+ L+ ++ DP+QR AK +++H FF Sbjct: 261 VIARELIEKMIAMDPQQR-----PSAKHVLKHPFF 290 >5E8V-A nrPDB Length = 316 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 63/302 (20%), Positives = 106/302 (35%), Gaps = 53/302 (17%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATG----RYYAMKILKKEVIVAKDEVAHTLTE 198 H + E L+GKG F +V K K A+KI E + ++ Sbjct: 4 HNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSD 63 Query: 199 NRVLQNSRHPFLTALKYSFQTHDRL----CFVMEYANGGELFFHLSRERVFSEDRARFYG 254 N +H + + + L + + G L +L+R V S + R G Sbjct: 64 I----NLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLG 118 Query: 255 AEIVSALDYLHS--------EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK----D 302 + + + +LHS + +V+RDLK N+++ D + DFGL D Sbjct: 119 SSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVD 178 Query: 303 GATMKTFCGTPEYLAPEV------LEDNDYGRAVDWWGLGVVMYEMMCG----------R 346 GT Y+APEV LE+ + + D + + +V++EM Sbjct: 179 DLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYE 238 Query: 347 LPFYNQDHEK-----LFELIL--MEEIRFPRTLGPE-----AKSLLSGLLKKDPKQRLGG 394 PF ++ E + + +L P L+ DP+ RL Sbjct: 239 PPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTA 298 Query: 395 GS 396 Sbjct: 299 QC 300 >2WTK-B nrPDB Length = 373 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 69/353 (19%), Positives = 124/353 (35%), Gaps = 80/353 (22%) Query: 150 FEYLKLLGKGTFG---KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 +E L ++GKG F V L + K TG Y ++ + E + + V E V + Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEAC-SNEMVTFLQGELHVSKLFN 68 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSALDYL 264 HP + + +F + L V + G + +E + ++ ALDY+ Sbjct: 69 HPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYI 128 Query: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPE-------Y 315 H V+R +K ++++ DG + ++ GL I G + P+ + Sbjct: 129 H-HMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPW 185 Query: 316 LAPEVLEDN--DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF--------------E 359 L+PEVL+ N Y D + +G+ E+ G +PF + ++ Sbjct: 186 LSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTS 245 Query: 360 LILMEEIRFP--------------------------------RTLGPEAKSLLSGLLKKD 387 I EE+ RT P + L+++ Sbjct: 246 TIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRN 305 Query: 388 PKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSE-TDTRYFD 439 P R A ++ H FF I K+ + P++ T F+ Sbjct: 306 PDAR-----PSASTLLNHSFFKQI-------KRRASEALPELLRPVTPITNFE 346 >3LLT-A nrPDB Length = 360 Score = 162 bits (410), Expect = 4e-40, Method: Composition-based stats. Identities = 71/367 (19%), Positives = 131/367 (35%), Gaps = 93/367 (25%) Query: 122 SGSPSDNSGAEEMEVSLAKPKHRVTMNE-FEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180 S + + E+ K + +N F ++ +G GTFG+V+L + +YYA+K+ Sbjct: 8 SSGRENLYFQGDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKV 67 Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFL-----TALKYSFQTHDRLCFVMEYANGGEL 235 ++ + E +L+ ++ + F +D +C + E G L Sbjct: 68 VRNIKKYTRS----AKIEADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSL 122 Query: 236 FFHLSRERV--FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH------ 287 + ++R F + + Y EI+ AL+YL + ++ + DLK EN++LD Sbjct: 123 YEIITRNNYNGFHIEDIKLYCIEILKALNYL-RKMSLTHTDLKPENILLDDPYFEKSLIT 181 Query: 288 -------------------IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328 IK+ DFG + T +Y APEV+ + + Sbjct: 182 VRRVTDGKKIQIYRTKSTGIKLIDFGCATF---KSDYHGSIINTRQYRAPEVILNLGWDV 238 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHEK---LFELILME--------------------- 364 + D W G V+ E+ G L F +H + + E I+ Sbjct: 239 SSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKD 298 Query: 365 --EIRFPRTLG--------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEI 402 ++ +P L +L+ DP R E+ Sbjct: 299 ELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLR-----PSPAEL 353 Query: 403 MQHRFFA 409 ++H+F Sbjct: 354 LKHKFLE 360 >3QD2-B nrPDB Length = 332 Score = 161 bits (407), Expect = 7e-40, Method: Composition-based stats. Identities = 60/338 (17%), Positives = 116/338 (34%), Gaps = 83/338 (24%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV-------------- 192 + +FE ++ +G+G FG V K K YA+K ++ E Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHP 64 Query: 193 -----------------AHTLTEN------------------------RVLQNSRHPFLT 211 + E R + Sbjct: 65 GIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTV 124 Query: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR---ARFYGAEIVSALDYLHSEK 268 L M+ L ++R + +I A+++LHS K Sbjct: 125 GQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHS-K 183 Query: 269 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA------------TMKTFCGTPEYL 316 +++RDLK N+ D +K+ DFGL +D T GT Y+ Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLG--- 373 +PE + N+Y VD + LG++++E++ ++ E++ + + ++FP Sbjct: 244 SPEQIHGNNYSHKVDIFSLGLILFELLYS----FSTQMERVRIITDVRNLKFPLLFTQKY 299 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 P+ ++ +L P +R +A +I+++ F + Sbjct: 300 PQEHMMVQDMLSPSPTER-----PEATDIIENAIFENL 332 >3SOC-A nrPDB Length = 322 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 100/292 (34%), Gaps = 50/292 (17%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 + L++ +G FG V + Y A+KI + + E L +H Sbjct: 26 LQLLEVKARGRFGCVWKAQ--LLNEYVAVKIF----PIQDKQSWQNEYEVYSLPGMKHEN 79 Query: 210 LTALKYS----FQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 + + L + + G L L + V S + + L YLH Sbjct: 80 ILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL-KANVVSWNELCHIAETMARGLAYLH 138 Query: 266 ---------SEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKTFCGTPE 314 + + +RD+K +N++L + I DFGL E K GT Sbjct: 139 EDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRR 198 Query: 315 YLAPEVLED-----NDYGRAVDWWGLGVVMYEMMCGR-----------LPF-----YNQD 353 Y+APEVLE D +D + +G+V++E+ LPF + Sbjct: 199 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPS 258 Query: 354 HEKLFELILMEEIR--FPRTLGPEA-----KSLLSGLLKKDPKQRLGGGSED 398 E + E+++ ++ R A + D + RL G Sbjct: 259 LEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVG 310 >3HNG-A nrPDB Length = 360 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 38/155 (24%), Positives = 75/155 (48%), Gaps = 6/155 (3%) Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 + + + Y ++ +++L S + ++RDL N++L ++ +KI DFGL ++ K Sbjct: 193 KEPITMEDLISYSFQVARGMEFL-SSRKCIHRDLAARNILLSENNVVKICDFGLARDIYK 251 Query: 302 DGATMK--TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLF 358 + ++ +++APE + D Y D W GV+++E+ G P+ ++ F Sbjct: 252 NPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDF 311 Query: 359 ELILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQR 391 L E +R P PE ++ +DPK+R Sbjct: 312 CSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKER 346 Score = 88.1 bits (217), Expect = 8e-18, Method: Composition-based stats. Identities = 32/129 (24%), Positives = 53/129 (41%), Gaps = 10/129 (7%) Query: 125 PSDNSGAEEME-VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILV-----KEKATGRYYAM 178 P + E+ E + K + K LG+G FGKV+ K+ T R A+ Sbjct: 3 PDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAV 62 Query: 179 KILKKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQT-HDRLCFVMEYANGGELF 236 K+LK+ + E +TE ++L + H + L + L ++EY G L Sbjct: 63 KMLKEGATAS--EYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLS 120 Query: 237 FHLSRERVF 245 +L +R Sbjct: 121 NYLKSKRDL 129 >3VHK-A nrPDB Length = 368 Score = 158 bits (399), Expect = 7e-39, Method: Composition-based stats. Identities = 41/169 (24%), Positives = 75/169 (44%), Gaps = 11/169 (6%) Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIK 301 + + + Y ++ +++L S K ++RDL N++L + +KI DFGL ++ K Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRK-CIHRDLAARNILLSEKNVVKICDFGLARDIYK 252 Query: 302 DGATMK--TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLF 358 D ++ +++APE + D Y D W GV+++E+ G P+ ++ F Sbjct: 253 DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 312 Query: 359 ELILMEEIRF--PRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 L E R P PE + +P QR E+++H Sbjct: 313 CRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR-----PTFSELVEH 356 Score = 86.2 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 47/115 (40%), Gaps = 9/115 (7%) Query: 136 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILV-----KEKATGRYYAMKILKKEVIVAKD 190 + K + + K LG+G FG+VI + AT R A+K+LK+ Sbjct: 17 LPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGA--THS 74 Query: 191 EVAHTLTENRVL-QNSRHPFLTALKYSFQ-THDRLCFVMEYANGGELFFHLSRER 243 E ++E ++L H + L + L ++E+ G L +L +R Sbjct: 75 EHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKR 129 >3G2F-A nrPDB Length = 336 Score = 157 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 67/346 (19%), Positives = 118/346 (34%), Gaps = 74/346 (21%) Query: 134 MEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA 193 ME + ++P + ++ + L+L+G+G +G V R A+K+ + Sbjct: 1 MEAAASEPS--LDLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVF------SFANRQ 50 Query: 194 HTLTENRVLQ--NSRHPFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSRERVFS 246 + + E + + H + + VMEY G L +LS Sbjct: 51 NFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDW 110 Query: 247 EDRARFYGAEIVSALDYLHSEKN--------VVYRDLKLENLMLDKDGHIKITDFGLCKE 298 R + L YLH+E + +RDL N+++ DG I+DFGL Sbjct: 111 VSSCR-LAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMR 169 Query: 299 GI--------KDGATMKTFCGTPEYLAPEVLED-------NDYGRAVDWWGLGVVMYEMM 343 ++ + GT Y+APEVLE + VD + LG++ +E+ Sbjct: 170 LTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIF 229 Query: 344 CGRL-PFYNQD-------------------HEKLFELILMEEIRFPRTLGP------EAK 377 F + ++ + +FP K Sbjct: 230 MRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLK 289 Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSP 423 + +D + RL A+E M A ++ K +SP Sbjct: 290 ETIEDCWDQDAEARLTAQC--AEERM-----AELMMIWERNKSVSP 328 >4BTK-A nrPDB Length = 337 Score = 155 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 57/297 (19%), Positives = 113/297 (38%), Gaps = 43/297 (14%) Query: 100 TTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKG 159 + A+Q +A L ++E M + G E+ ++ P + V + ++ LK +G G Sbjct: 22 SNAMQCLAAAL--KDETNM---------SGGGEQADIL---PANYVVKDRWKVLKKIGGG 67 Query: 160 TFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH-PFLTALKYSFQ 218 FG++ + T A+K+ A+ E VL+ + + + Sbjct: 68 GFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGR 122 Query: 219 THDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLK 276 VM+ G L F+ G +I+ +++ +HS ++RD+K Sbjct: 123 NEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS-VGFLHRDIK 180 Query: 277 LENL----MLDKDGHIKITDFGLCKEG------IKDGATMKTFCGTPEYLAPEVLEDNDY 326 N + + DFGL ++ ++ + F GT Y + ++ + Sbjct: 181 PSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM 240 Query: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383 GR D W L ++ E G+LP+ ++ +I + E + LL + Sbjct: 241 GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK---------YEHRMLLKHM 288 >5FQD-C nrPDB Length = 341 Score = 153 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 62/324 (19%), Positives = 120/324 (37%), Gaps = 50/324 (15%) Query: 130 GAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAK 189 G M S + +++ ++ +G G+FG + L G A+K + K Sbjct: 1 GGGRMASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-----LESQK 55 Query: 190 DEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFS 246 L E+++ + + + +++ Q D VM+ +LF SR F+ Sbjct: 56 ARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRR--FT 113 Query: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI-K--ITDFGLCKEGIKDG 303 +++S ++Y+H+ KN ++RD+K +N ++ H K + DFGL K+ + Sbjct: 114 MKTVLMLADQMISRIEYVHT-KNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNR 172 Query: 304 ATM-------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---D 353 K GT Y + + R D LG V+ LP+ Sbjct: 173 TRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAAT 232 Query: 354 HEKLFELILMEEIRFP-----RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKE------- 401 ++ +E I +++ P + E L+ R G E+A + Sbjct: 233 KKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYC-------R-GLRFEEAPDYMYLRQL 284 Query: 402 ------IMQHRFFAGIVWQHVYEK 419 + H++ W + +K Sbjct: 285 FRILFRTLNHQYDYTFDWTMLKQK 308 >4LFI-A nrPDB Length = 374 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 70/357 (19%), Positives = 128/357 (35%), Gaps = 89/357 (24%) Query: 131 AEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM------------ 178 + E ++ ++E +G+G + +V + + + Sbjct: 25 YWDYENTVID--WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK 82 Query: 179 ------------KILKKEVIVAKDEVAHTLTENRVLQNSR----------HPFLTALKYS 216 K+ + KD+ E VL+ R H + L Sbjct: 83 REIKILTDLSNEKVPPTTLPFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDI 141 Query: 217 FQTH--DRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274 + V EY + + + ++ RFY E++ ALDY HS +++RD Sbjct: 142 IKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHS-MGIMHRD 197 Query: 275 LKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-EDNDYGRAVDW 332 +K N+M+D K+ +++ D+GL E + + PE+L + Y ++D Sbjct: 198 VKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 256 Query: 333 WGLGVVMYEMMCGRLPFYN--QDHEKLFELI------------LMEEIRFPRTL------ 372 W G ++ M+ R PF++ + ++L +++ L EI PR Sbjct: 257 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 316 Query: 373 ------------------GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 E L+ LL+ D ++RL AKE M H +FA I Sbjct: 317 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPI 368 >5VDK-A nrPDB Length = 297 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 106/281 (37%), Gaps = 43/281 (15%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS-R 206 EF ++ +G G FG V ++ G YA+K K +E L E Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNE-NSALHEVYAHAVLGH 73 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE----RVFSEDRARFYGAEIVSALD 262 HP + S+ D + EY NGG L +S F E + + +I L+ Sbjct: 74 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 133 Query: 263 YLHSEKNVVYRDLKLENLML------DKDGHI-----------------KITDFGLCKEG 299 Y+H+ ++V+ D+K N+ + + G I KI D G Sbjct: 134 YIHNS-SMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI 192 Query: 300 IKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCG--RLPFYNQDHEK 356 K K G +LA E+L+++ + D + LG+ + + G LP + Sbjct: 193 NKP----KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGAESLP----TNGA 243 Query: 357 LFELILMEEI-RFPRTLGPEAKSLLSGLLKKDPKQRLGGGS 396 + I P+ L SLL +++ D +QR + Sbjct: 244 AWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAA 284 >2QLU-A nrPDB Length = 314 Score = 151 bits (382), Expect = 6e-37, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 107/296 (36%), Gaps = 51/296 (17%) Query: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 V + L++ +G FG V + + A+KI + + + E Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQLMND--FVAVKIF----PLQDKQSWQSEREIFSTPG 65 Query: 205 SRHPFLTAL----KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260 +H L K L + + + G L +L + + + + + Sbjct: 66 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSRG 124 Query: 261 LDYLH----------SEKNVVYRDLKLENLMLDKDGHIKITDFGLCK--EGIKDGATMKT 308 L YLH + ++ +RD K +N++L D + DFGL E K Sbjct: 125 LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHG 184 Query: 309 FCGTPEYLAPEVLED-----NDYGRAVDWWGLGVVMYEMMCGR-----------LPF--- 349 GT Y+APEVLE D +D + +G+V++E++ LPF Sbjct: 185 QVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEE 244 Query: 350 --YNQDHEKLFELILMEEIR--FPRTL--GPEAKSL---LSGLLKKDPKQRLGGGS 396 + E+L E+++ +++R P L + D + RL G Sbjct: 245 IGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGC 300 >2X7G-A nrPDB Length = 389 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 64/371 (17%), Positives = 114/371 (30%), Gaps = 120/371 (32%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR- 206 + ++ LG G F V L + R+ AMK++K A+ L E ++L+ R Sbjct: 31 GRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK----SAQHYTETALDEIKLLKCVRE 86 Query: 207 ----HPF---LTALKYSFQTHD----RLCFVMEYANGGELFFHLSRE-RVFSEDRARFYG 254 P + L F+ +C V E L + + + + Sbjct: 87 SDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSII 146 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLM--------------------------------- 281 +++ LDYLHS+ +++ D+K EN++ Sbjct: 147 RQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVST 206 Query: 282 ----------LDKDG----HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYG 327 LD +KI D G K T +Y + EVL Y Sbjct: 207 APAADLLVNPLDPRNADKIRVKIADLGNACWVHK---HFTEDIQTRQYRSIEVLIGAGYS 263 Query: 328 RAVDWWGLGVVMYEMMCGRLPF-------YNQDHEKLFELI------------------- 361 D W + +E+ G F Y++D + + +I Sbjct: 264 TPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSRE 323 Query: 362 ----------------------LMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDA 399 L+E+ +P + L +L+ P++R A Sbjct: 324 FFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKR-----ASA 378 Query: 400 KEIMQHRFFAG 410 E ++H + Sbjct: 379 GECLRHPWLNS 389 >4NFN-A nrPDB Length = 309 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 51/269 (18%), Positives = 102/269 (37%), Gaps = 32/269 (11%) Query: 128 NSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIV 187 + G E+ ++ P + V + ++ LK +G G FG++ + T A+K+ Sbjct: 4 SGGGEQADIL---PANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ES 55 Query: 188 AKDEVAHTLTENRVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERV 244 A+ E VL+ + + + VM+ G L Sbjct: 56 AQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGT 114 Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENL----MLDKDGHIKITDFGLCKEG- 299 F+ G +I+ +++ +HS ++RD+K N + + DFGL ++ Sbjct: 115 FTLSTTLRLGKQILESIEAIHS-VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYT 173 Query: 300 -----IKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354 ++ + F GT Y + ++ + GR D W L ++ E G+LP+ Sbjct: 174 NTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKD 233 Query: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGL 383 ++ +I + E + LL + Sbjct: 234 KEQVGMIKEK---------YEHRMLLKHM 253 >4TN6-A nrPDB Length = 318 Score = 148 bits (375), Expect = 4e-36, Method: Composition-based stats. Identities = 56/238 (23%), Positives = 99/238 (41%), Gaps = 24/238 (10%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR- 206 N + + +G G+FG + L + A G A+K+ E + K H E+++ + + Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL---ECVKTKHPQLHI--ESKIYKMMQG 61 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 + +++ D VME +LF SR+ FS +++S ++Y+ Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRK--FSLKTVLLLADQMISRIEYI 119 Query: 265 HSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIK-------DGATMKTFCGTPE 314 HS KN ++RD+K +N ++ K + I DFGL K+ K GT Sbjct: 120 HS-KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTAR 178 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEEIRFP 369 Y + + R D LG V+ G LP+ + +E I +++ P Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTP 236 >5J0A-A nrPDB Length = 300 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 104/288 (36%), Gaps = 37/288 (12%) Query: 152 YLKLLGKGTFGKVILVKEKATGRYY---AMKILKKEVIVAKDEV--AHTLTENRVLQNSR 206 +++ LG GT V L+K G + A+K + V + E ++L++ Sbjct: 13 FMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLH 72 Query: 207 HPFLTALKYSFQ-THDRLCFVMEYANGGELFFHLSRE-----RVFSEDRARFYGAEIVSA 260 HP + + + LC MEY L + F + Sbjct: 73 HPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARG 132 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDG-HIKITDFGLC---KEGIKDGATMKTFCGTPEYL 316 L YLH EK +++ D+K N+++ D IKI D G+ E ++ + GT + Sbjct: 133 LKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWK 192 Query: 317 APEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRF------- 368 E +E+N D + G+ ++EMM +P N ++ E +E F Sbjct: 193 PKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYA 252 Query: 369 -----PRTLGPE-------AKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 P E L S +DPK R E ++ Sbjct: 253 ALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAH--IVEALE 298 >4WUA-A nrPDB Length = 401 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 61/373 (16%), Positives = 114/373 (30%), Gaps = 122/373 (32%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 + ++ LG G F V L + ++ AMK++K A+ L E R+L++ R+ Sbjct: 41 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK----SAEHYTETALDEIRLLKSVRN 96 Query: 208 -----PF---LTALKYSFQ----THDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYG 254 P + L F+ +C V E L + + + + Sbjct: 97 SDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKII 156 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLD------------------------------- 283 +++ LDYLH++ +++ D+K EN++L Sbjct: 157 QQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVST 216 Query: 284 ------------------KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + +KI D G K T +Y + EVL + Sbjct: 217 APATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHK---HFTEDIQTRQYRSLEVLIGSG 273 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEK----------LFEL--------------- 360 Y D W + +E+ G F E+ + EL Sbjct: 274 YNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYS 333 Query: 361 -----------------------ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSE 397 +L+E+ + + L +L+ P++R Sbjct: 334 KEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKR-----A 388 Query: 398 DAKEIMQHRFFAG 410 A E ++H + Sbjct: 389 TAAECLRHPWLNS 401 >4RT7-A nrPDB Length = 415 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 45/222 (20%), Positives = 92/222 (41%), Gaps = 23/222 (10%) Query: 197 TENRVLQNSRHPFLTALKY-SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255 E ++ +S ++ L SF + D + EY + V + + + Sbjct: 198 REVQIHPDSDQ--ISGLHGNSFHSEDEI----EY-ENQKRLEEEEDLNVLTFEDLLCFAY 250 Query: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD-GATMKTFCGTP- 313 ++ +++L K+ V+RDL N+++ +KI DFGL ++ + D ++ P Sbjct: 251 QVAKGMEFL-EFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPV 309 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTL 372 +++APE L + Y D W G++++E+ G P+ + F ++ + + Sbjct: 310 KWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPF 369 Query: 373 --GPEAKSLLSGLLKKDPKQR---------LGGGSEDAKEIM 403 E ++ D ++R LG DA+E M Sbjct: 370 YATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAM 411 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 29/137 (21%), Positives = 56/137 (40%), Gaps = 8/137 (5%) Query: 113 QEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE--- 169 + + +M +GS + + K E+ K+LG G FGKV+ Sbjct: 30 ESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGI 89 Query: 170 KATG--RYYAMKILKKEVIVAKDEVAHTLTENRVLQNS-RHPFLTALKYSFQTHDRLCFV 226 TG A+K+LK++ ++ E ++E +++ H + L + + + Sbjct: 90 SKTGVSIQVAVKMLKEKADSSEREA--LMSELKMMTQLGSHENIVNLLGACTLSGPIYLI 147 Query: 227 MEYANGGELFFHLSRER 243 EY G+L +L +R Sbjct: 148 FEYCCYGDLLNYLRSKR 164 >5X1R-A nrPDB Length = 302 Score = 147 bits (372), Expect = 8e-36, Method: Composition-based stats. Identities = 56/300 (18%), Positives = 113/300 (37%), Gaps = 29/300 (9%) Query: 129 SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA 188 SG + + NEFE + +G+G FG V + R A+K + Sbjct: 2 SGTGITKPNSNSLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAK 61 Query: 189 KDE------------------VAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYA 230 +++ + + E R+L HP L + ++ + ++ Sbjct: 62 RNDDLSIGLRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFY 121 Query: 231 NGGELFFH-LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIK 289 +G L + E R + SA++ +H ++ ++RD+ L+N+ + + Sbjct: 122 SGTTLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIH-QEGYLHRDISLDNIQIQESQLPV 180 Query: 290 ITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA---VDWWGLGVVMYEMMCGR 346 + DFG ++ I + + P + E +N G D + LG V++ ++ G Sbjct: 181 LLDFGSARKEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGS 240 Query: 347 LPFYN--QDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 P + + E ++ + R P PE + L P+ R E A E+++ Sbjct: 241 PPPVSVVRSIEDSYQPLTE---RRPAGYSPELLRTVDRALALKPEDRPQTIDEMA-ELLE 296 >3SV0-A nrPDB Length = 483 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 48/235 (20%), Positives = 98/235 (41%), Gaps = 24/235 (10%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 207 N+F + +G G+FG++ L T A+K + K + L E+++ + + Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-----LENVKTKHPQLLYESKIYRILQG 61 Query: 208 P-FLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDYL 264 + +++ D VM+ +LF SR+ S ++++ ++++ Sbjct: 62 GTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRK--LSLKTVLMLADQMINRVEFV 119 Query: 265 HSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATM-------KTFCGTPE 314 HS K+ ++RD+K +N ++ + + I DFGL K+ K GT Sbjct: 120 HS-KSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTAR 178 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEEI 366 Y + + R D LG V+ + G LP+ ++ +E I +++ Sbjct: 179 YASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKV 233 >5C01-A nrPDB Length = 342 Score = 145 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 70/323 (21%), Positives = 111/323 (34%), Gaps = 55/323 (17%) Query: 116 EEMDFRSGSPSDNSGAEEMEVSLAKPK---------HRVTMNEFEYLKLLGKGTFGKVIL 166 E + G+ + S M + A P+ HRV E L LG+GT V Sbjct: 17 TENLYFQGAMGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYE 76 Query: 167 VKEKATG------------------------RYYAMKILKKEVIVAKDEVAHTLTE-NRV 201 + + G +K+L + ++A E + Sbjct: 77 GRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDP----SHHDIALAFYETASL 132 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSA 260 + H L + V EY G L L RER ++ SA Sbjct: 133 MSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASA 192 Query: 261 LDYLHSEKNVVYRDLKLENLML-------DKDGHIKITDFGLCKEGIKDGATMKTFCGTP 313 L YL KN+V+ ++ N++L IK++D G+ + ++ Sbjct: 193 LSYL-ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERI---- 247 Query: 314 EYLAPEVLED--NDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPR 370 +LAPE L N A+D WG G + E+ G P ++ + E + R P Sbjct: 248 PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPE 306 Query: 371 TLGPEAKSLLSGLLKKDPKQRLG 393 P+ +L S L +P QR Sbjct: 307 PSCPQLATLTSQCLTYEPTQRPS 329 >2CHL-A nrPDB Length = 351 Score = 145 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 62/250 (24%), Positives = 101/250 (40%), Gaps = 30/250 (12%) Query: 126 SDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 185 ++N + M V + P F K +G G FG++ L K T Y A+K+ E Sbjct: 15 TENLYFQSMGVLMVGP-------NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL---EP 64 Query: 186 IVAKDEVAHTLTENRVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRE 242 + ++ H E R + + + Y V+E +LF + Sbjct: 65 MKSRAPQLHL--EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDL--CD 120 Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-----IKITDFGLCK 297 R FS +++S ++Y+HS KN++YRD+K EN ++ + G+ I I DF L K Sbjct: 121 RTFSLKTVLMIAIQLISRMEYVHS-KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAK 179 Query: 298 EGIKDGAT-------MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350 E I K+ GT Y++ + R D LG + + G LP+ Sbjct: 180 EYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQ 239 Query: 351 NQDHEKLFEL 360 + L E Sbjct: 240 GLKADTLKER 249 >2CMW-A nrPDB Length = 310 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 61/255 (23%), Positives = 100/255 (39%), Gaps = 32/255 (12%) Query: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH--P 208 K +G G FG++ L K T Y A+K+ E I ++ H E R + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKL---EPIKSRAPQLHL--EYRFYKQLGSAGE 57 Query: 209 FLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266 L + Y V+E +LF +R F+ +++S ++Y+HS Sbjct: 58 GLPQVYYFGPCGKYNAMVLELLGPSLEDLFDL--CDRTFTLKTVLMIAIQLLSRMEYVHS 115 Query: 267 EKNVVYRDLKLENLMLDKDGH-----IKITDFGLCKEGIKDGAT-------MKTFCGTPE 314 KN++YRD+K EN ++ + G+ I I DFGL KE I K+ GT Sbjct: 116 -KNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 174 Query: 315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN---QDHEKLFELILMEEIRFP-- 369 Y++ + R D LG + + G LP+ ++ ++ I + P Sbjct: 175 YMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIE 234 Query: 370 ---RTLGPEAKSLLS 381 E + L Sbjct: 235 ALCENFPEEMATYLR 249 >4L00-A nrPDB Length = 304 Score = 141 bits (355), Expect = 9e-34, Method: Composition-based stats. Identities = 57/298 (19%), Positives = 116/298 (38%), Gaps = 37/298 (12%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVK------EKATGRYYAMKILKKEVIVAKDEVAHTL 196 R+ + + LG+GT + ++ T +K++ K + + +++ Sbjct: 20 DRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAF 79 Query: 197 TEN-RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-RVFSEDRARFYG 254 E +++ H + L V E+ GG L + R+ V + Sbjct: 80 FEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVA 139 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-------IKITDFGLCKEGIKDGATMK 307 ++ SAL YL +K++V+ ++ +NL+L ++G IK++D G+ + ++ Sbjct: 140 KQLASALSYL-EDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIE 198 Query: 308 TFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEE 365 ++APE +ED+ A D W G ++E+ G +P ++ + E Sbjct: 199 RI----PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIE-KERFYESR 253 Query: 366 IRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSP 423 R E L++ + DP QR FF I+ ++ +P Sbjct: 254 CRPVTPSCKELADLMTRCMNYDPNQR--------------PFFRAIMRDINKLEEQNP 297 >2C47-A nrPDB Length = 313 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 97/254 (38%), Gaps = 27/254 (10%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-H 207 F K +G G FG++ L K T Y A+K+ E I ++ H E R + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL---EPIKSRAPQLHL--EYRFYKQLSAT 59 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 + + Y V+E +R F+ ++++ ++Y+H+ Sbjct: 60 EGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHT- 118 Query: 268 KNVVYRDLKLENLMLDKDGH-----IKITDFGLCKEGIKDGAT-------MKTFCGTPEY 315 K+++YRD+K EN ++ + G I I DFGL KE I K+ GT Y Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 178 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN---QDHEKLFELILMEEIRFP--- 369 ++ + R D LG + + G LP+ ++ ++ I + P Sbjct: 179 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 238 Query: 370 --RTLGPEAKSLLS 381 E + L Sbjct: 239 LCENFPEEMATYLR 252 >4F9B-A nrPDB Length = 361 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 73/353 (20%), Positives = 113/353 (32%), Gaps = 107/353 (30%) Query: 150 FEYLKLLGKGTFGKVILVK---EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NS 205 F+ +G+GTF V L + A+K L + E + L Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL-----IPTSHPIRIAAELQCLTVAG 77 Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 + +KY F+ +D + M Y L+ S R Y + AL +H Sbjct: 78 GQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKALKRIH 134 Query: 266 SEKNVVYRDLKLENLMLDKDGHIK---ITDFGLCKEGIKDGATMKTFC------------ 310 + +V+RD+K N + ++ +K + DFGL + + F Sbjct: 135 -QFGIVHRDVKPSNFLYNR--RLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQN 191 Query: 311 ----------------GTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFY--- 350 GTP + APEVL A+D W GV+ ++ GR PFY Sbjct: 192 KCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKAS 251 Query: 351 ------------------------------------NQDHEKLFELILMEEIRFPR---- 370 QD KL E + + P+ Sbjct: 252 DDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSD 311 Query: 371 ------------TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 411 + EA LL LL +P R+ A+E + H FF + Sbjct: 312 IQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRI-----TAEEALLHPFFKDM 359 >4WOV-A nrPDB Length = 317 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 64/287 (22%), Positives = 100/287 (34%), Gaps = 46/287 (16%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATG------------------------RYYAM 178 HRV E L LG+GT V + + G + Sbjct: 30 HRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVL 89 Query: 179 KILKKEVIVAKDEVAHTLTE-NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237 K+L + ++A E ++ H L + V EY G L Sbjct: 90 KVLDP----SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 145 Query: 238 HLSRERV-FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML-------DKDGHIK 289 L RER ++ SAL YL KN+V+ ++ N++L IK Sbjct: 146 WLRRERGHVPMAWKMVVAQQLASALSYL-ENKNLVHGNVCGRNILLARLGLAEGTSPFIK 204 Query: 290 ITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED--NDYGRAVDWWGLGVVMYEMMC-GR 346 ++D G+ + ++ +LAPE L N A+D WG G + E+ G Sbjct: 205 LSDPGVGLGALSREERVERI----PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGE 260 Query: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 P ++ + E + R P P+ +L S L +P QR Sbjct: 261 APLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 306 >5M07-A nrPDB Length = 276 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 99/274 (36%), Gaps = 36/274 (13%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 VT + +++LG G+V LV+ + A+K+L + + E V Sbjct: 24 ASGVTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEV 83 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVS 259 HP + + + +L M+Y +G + H++ V + Sbjct: 84 AARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAG 143 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDK----DGHIKITDFGLCKEGIKDGATMKTFCGTPEY 315 ALDY H ++ +++RD+ N++L D I + DFG+ + P Y Sbjct: 144 ALDYAH-QRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ--------------PSY 188 Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRT--LG 373 APE+ D D + L + + G P + ++ P+ Sbjct: 189 PAPELSAGADVDGRADQYALALTAIHLFAGAPP---------VDRSHTGPLQPPKLSAFR 239 Query: 374 PEAKSL---LSGLLKKDPKQRLGGGSEDAKEIMQ 404 P+ L LS L P R G E A + M Sbjct: 240 PDLARLDGVLSRALATAPADRFGSCREFA-DAMN 272 >5X18-A nrPDB Length = 295 Score = 138 bits (349), Expect = 4e-33, Method: Composition-based stats. Identities = 50/253 (19%), Positives = 96/253 (37%), Gaps = 32/253 (12%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH- 207 ++ K +G+G+FG + G A+K K E E + + Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIK-----FEPRKTEAPQLRDEYKTYKILNGT 62 Query: 208 PFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265 P + Y Q V++ +LF R+ FS ++++ ++ LH Sbjct: 63 PNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRK--FSVKTVVQVAVQMITLIEDLH 120 Query: 266 SEKNVVYRDLKLENLMLDKDGH-----IKITDFGLCKEGIKDGAT-------MKTFCGTP 313 + +++YRD+K +N ++ + G I + DFG+ K+ K+ GT Sbjct: 121 AH-DLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTA 179 Query: 314 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN---QDHEKLFELILMEEIRFPR 370 Y++ + R D LG V + + G LP+ ++++ +E I ++ Sbjct: 180 RYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKR---- 235 Query: 371 TLGPEAKSLLSGL 383 L GL Sbjct: 236 --STNVYDLAQGL 246 >4NT4-A nrPDB Length = 312 Score = 135 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 96/250 (38%), Gaps = 32/250 (12%) Query: 130 GAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAK 189 + M V + P F K +G G FG++ L K + A+K+ E + +K Sbjct: 1 AMDPMAVLMVGP-------NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM---EPMKSK 50 Query: 190 DEVAHTLTENRVLQNSRHPF----LTALKYSFQTHDRL-CFVMEYANGG--ELFFHLSRE 242 H L S + + + R V+E +LF +R+ Sbjct: 51 APQLHLEYRFYKLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARK 110 Query: 243 RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH-----IKITDFGLCK 297 FS +++ ++Y+HS ++++YRD+K EN ++ + I I DFGL K Sbjct: 111 --FSLKTVLMIAKQLLHRIEYVHS-RHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK 167 Query: 298 EGIKDGAT-------MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350 E I K+ GT Y++ + R D LG + + G LP+ Sbjct: 168 EYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQ 227 Query: 351 NQDHEKLFEL 360 + L E Sbjct: 228 GLKADTLKER 237 >5USZ-A nrPDB Length = 289 Score = 135 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 45/269 (16%), Positives = 100/269 (37%), Gaps = 27/269 (10%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY-------YAMKILKKEVIVAKDEVAHT 195 H++ + + + LG+GTF K+ + G Y +K+L K ++ Sbjct: 3 HKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK---AHRNYSESF 59 Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYG 254 ++ H L D V E+ G L +L + + + Sbjct: 60 FEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVA 119 Query: 255 AEIVSALDYLHSEKNVVYRDLKLENLML--------DKDGHIKITDFGLCKEGIKDGATM 306 ++ +A+ +L E +++ ++ +N++L IK++D G+ + Sbjct: 120 KQLAAAMHFL-EENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQ 178 Query: 307 KTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILME 364 + ++ PE +E+ + A D W G ++E+ G P D ++ + + Sbjct: 179 ERI----PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQ-FYED 233 Query: 365 EIRFPRTLGPEAKSLLSGLLKKDPKQRLG 393 + P E +L++ + +P R Sbjct: 234 RHQLPAPKAAELANLINNCMDYEPDHRPS 262 >5OAT-A nrPDB Length = 411 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 68/339 (20%), Positives = 123/339 (36%), Gaps = 69/339 (20%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY-----YAMKILKKEVIVAKD-EVAHTL 196 + +T+N+ K + KGT G V K K +A+K++ I E+ + Sbjct: 6 NPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAM 65 Query: 197 T------------------ENRVLQNSRH----PFLTALKYSFQT--------------- 219 E + +H P + A+ F Sbjct: 66 YRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGE 125 Query: 220 --HDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKL 277 + L +M+ + L LS S + A+++ + ++ + + +RDLK Sbjct: 126 GRNMSLFLLMKRYDC-NLQSFLSTAP--STRTSLLLLAQLLEGVAHM-TAHGIAHRDLKS 181 Query: 278 ENLMLD----KDGHIKITDFG--LCKEGIKDGATMKTF----CGTPEYLAPEVLEDND-- 325 +NL+LD + + I+DFG L + ++ G +APE++ Sbjct: 182 DNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGT 241 Query: 326 -----YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380 Y D W +G + YE+ PFY K F + + P + ++L+ Sbjct: 242 FSVLNYS-KADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALV 300 Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEK 419 + LLK++P +RL E A + Q +A W K Sbjct: 301 ANLLKRNPNKRL--DPEVAANVCQLFLWAPSTWLKPGLK 337 >1CSN-A nrPDB Length = 298 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 47/260 (18%), Positives = 94/260 (36%), Gaps = 27/260 (10%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 ++ V ++ + +G+G+FG + + A+K + ++ ++ Sbjct: 4 QNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKF--EPRRSDAPQLRDEYRTYKL 61 Query: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS-RERVFSEDRARFYGAEIVSA 260 L + + Y Q V++ G L L R FS ++++ Sbjct: 62 LAGCT--GIPNVYYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLAR 118 Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDG-----HIKITDFGLCKEGIKDGAT-------MKT 308 + +H EK++VYRD+K +N ++ + I + DFG+ K K Sbjct: 119 VQSIH-EKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKN 177 Query: 309 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEE 365 GT Y++ + R D LG V + G LP+ +++ +E I ++ Sbjct: 178 LSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKK 237 Query: 366 IRFP-----RTLGPEAKSLL 380 P E + Sbjct: 238 QSTPLRELCAGFPEEFYKYM 257 >4XHH-A nrPDB Length = 403 Score = 126 bits (316), Expect = 3e-29, Method: Composition-based stats. Identities = 42/239 (17%), Positives = 93/239 (38%), Gaps = 30/239 (12%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH- 207 +F + +G G+FG + +G A+ + + E+RV + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI-----RLESIRSRHPQLDYESRVYKYLSGG 62 Query: 208 ---PFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALD 262 PF+ ++ + + V++ +LF + R+ FS +++ + Sbjct: 63 VGIPFI---RWFGREGEYNAMVIDLLGPSLEDLFNYCHRK--FSFKTVIMLALQMICRVQ 117 Query: 263 YLHSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATM-------KTFCGT 312 Y+H ++ ++RD+K +N ++ + + + DFGL K+ K+ GT Sbjct: 118 YIHG-RSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGT 176 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN---QDHEKLFELILMEEIRF 368 Y + + R D LG ++ G LP+ ++ ++ IL +++ Sbjct: 177 ARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCI 235 >6BBQ-A nrPDB Length = 520 Score = 124 bits (312), Expect = 7e-29, Method: Composition-based stats. Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 29/123 (23%) Query: 8 KEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRE-APLNNFSVAQCQLMKTE 66 +EGWL K G +KTW+ R+F+L ++ + Y E D + R PL N S+ + E Sbjct: 215 REGWLLKLGGRVKTWKRRWFILTDNCLY--YFEYTTDKEPRGIIPLENLSIRE-----VE 267 Query: 67 RPR-PNTFII-------------------RCLQWTTVIERTFHVETPEEREEWTTAIQTV 106 PR PN F + R ++ V+ R +PEE+EEW +I+ Sbjct: 268 DPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYR-ISAPSPEEKEEWMKSIKAS 326 Query: 107 ADG 109 Sbjct: 327 ISR 329 >2PZI-A nrPDB Length = 681 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 39/273 (14%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKA-TGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + ++E + G G + L ++ GR +K L +A + L Sbjct: 76 DIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFL 133 Query: 203 QNSRHPFLTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257 HP + + + DR VMEY G L S+ + A Y EI Sbjct: 134 AEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL--KRSKGQKLPVAEAIAYLLEI 191 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 + AL YLHS +VY DLK EN+ML ++ +K+ D G G GTP + A Sbjct: 192 LPALSYLHS-IGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQA 245 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI--RFPRTLGPE 375 PE++ A D + +G + + LP P P Sbjct: 246 PEIVRTGP-TVATDIYTVGRTLAA-LTLDLP------------TRNGRYVDGLPED-DPV 290 Query: 376 AKS------LLSGLLKKDPKQRLGGGSEDAKEI 402 K+ LL + DP+QR E + ++ Sbjct: 291 LKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQL 323 >4Y12-A nrPDB Length = 375 Score = 123 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 100/273 (36%), Gaps = 39/273 (14%) Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKA-TGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202 + ++E + G G + L ++ GR +K L +A + L Sbjct: 115 DIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFL 172 Query: 203 QNSRHPFLTALKYSFQTHDRL-----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257 HP + + + DR VMEY G L S+ + A Y EI Sbjct: 173 AEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL--KRSKGQKLPVAEAIAYLLEI 230 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 + AL YLHS +VY DLK EN+ML ++ +K+ D G G GTP + A Sbjct: 231 LPALSYLHS-IGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQA 284 Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI--RFPRTLGPE 375 PE++ A D + +G + + LP P P Sbjct: 285 PEIVRTGP-TVATDIYTVGRTLAA-LTLDLP------------TRNGRYVDGLPED-DPV 329 Query: 376 AKS------LLSGLLKKDPKQRLGGGSEDAKEI 402 K+ LL + DP+QR E + ++ Sbjct: 330 LKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQL 362 >2R09-A nrPDB Length = 347 Score = 123 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 29/123 (23%) Query: 8 KEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRE-APLNNFSVAQCQLMKTE 66 +EGWL K G +KTW+ R+F+L ++ + Y E D + R PL N S+ + E Sbjct: 215 REGWLLKLGGRVKTWKRRWFILTDNCLY--YFEYTTDKEPRGIIPLENLSIRE-----VE 267 Query: 67 RPR-PNTFII-------------------RCLQWTTVIERTFHVETPEEREEWTTAIQTV 106 PR PN F + R ++ V+ R +PEE+EEW +I+ Sbjct: 268 DPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYR-ISAPSPEEKEEWMKSIKAS 326 Query: 107 ADG 109 Sbjct: 327 ISR 329 >4XHL-A nrPDB Length = 394 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 42/237 (17%), Positives = 91/237 (38%), Gaps = 30/237 (12%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH- 207 +F + +G G+FG + +G A+ + + E+RV + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI-----RLESIRSRHPQLDYESRVYRYLSGG 62 Query: 208 ---PFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALD 262 PF+ ++ + + V++ +LF + R FS ++ + Sbjct: 63 VGIPFI---RWFGREGEYNAMVIDLLGPSLEDLFNYCHRR--FSFKTVIMLALQMFCRIQ 117 Query: 263 YLHSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATM-------KTFCGT 312 Y+H ++ ++RD+K +N ++ + + + DFGL K+ K+ GT Sbjct: 118 YIHG-RSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGT 176 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN---QDHEKLFELILMEEI 366 Y + + R D LG V+ G LP+ ++ ++ I+ +++ Sbjct: 177 ARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKL 233 >5UV4-A nrPDB Length = 311 Score = 121 bits (303), Expect = 9e-28, Method: Composition-based stats. Identities = 42/205 (20%), Positives = 82/205 (40%), Gaps = 15/205 (7%) Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 213 +++G+ G G +K LK+ +K E + E + L + RHP L L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKEFS---REIKKLGSVRHPNLVPL 86 Query: 214 KYSFQ--THDRLCFVMEYANGGELFFHL-----SRERVFSEDRARFYGAEIVSALDYLHS 266 + + + +YA+ L +L S + +I LDYLH+ Sbjct: 87 RGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHN 146 Query: 267 EKNVVYRDLKLENLML-DKDGHIKITDFGLCKEGIKDGATMKTF-CGTPEYLAPEVLEDN 324 E+ + + ++K N+++ + +TD+ L + G + G Y PE + Sbjct: 147 ERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTS 206 Query: 325 D--YGRAVDWWGLGVVMYEMMCGRL 347 D + GV++ E++ G++ Sbjct: 207 KPCPSLKSDVYAFGVILLELLTGKI 231 >4JRN-A nrPDB Length = 372 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 48/275 (17%), Positives = 96/275 (34%), Gaps = 48/275 (17%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-------- 206 LG G F V + T A+K+ E + + E+ +N Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 207 ---HPF-----LTALKYSFQTHD----------RLCFVMEYANGGELFFHLS-------- 240 F + L+ + + F++ ++ +S Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300 + F + ++ + + + ++ +V+ D+K N +L KDG + + DFG + Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQ-GIVHTDIKPANFLLLKDGRLFLGDFGTYRINN 253 Query: 301 KDGATMKTFCGTPEYLAPE---VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357 G GTP Y PE Y D W LG+ +Y + C P + + Sbjct: 254 SVGRA----IGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---TPADGI 306 Query: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 ++ + + + + L+ LL +DP++R+ Sbjct: 307 WDYLHFADC---PSTPELVQDLIRSLLNRDPQKRM 338 >4L68-A nrPDB Length = 340 Score = 115 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 42/191 (21%), Positives = 65/191 (34%), Gaps = 12/191 (6%) Query: 162 GKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHD 221 G G A+K L K E L RH L L + Sbjct: 54 GTTYKAL-LPDGSALAVKHLS----TCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEE 108 Query: 222 RLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLHS--EKNVVYRDLKLE 278 V +Y + G L L R G L +LH ++++++ Sbjct: 109 EKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSS 168 Query: 279 NLMLDKDGHIKITDFGLCKEGIKDGATMKTFC----GTPEYLAPEVLEDNDYGRAVDWWG 334 +++D+D +I D GL + + +F G Y+APE D +G Sbjct: 169 VILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYG 228 Query: 335 LGVVMYEMMCG 345 LGVV+ E+ G Sbjct: 229 LGVVLLELATG 239 >6EQI-C nrPDB Length = 433 Score = 114 bits (286), Expect = 7e-26, Method: Composition-based stats. Identities = 59/339 (17%), Positives = 122/339 (35%), Gaps = 77/339 (22%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATG-----RYYAMKILKKEVIVAKDE--VAHTLTE- 198 ++E + + + KG V K K A+K++ + + + E Sbjct: 14 LDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRET 73 Query: 199 --------------NRVLQNSR-----HPFLTALKYSFQT-------------------- 219 + + + HP + + F Sbjct: 74 VPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRI 133 Query: 220 -------HDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272 + L VM+ + L +L R++ + + ++++ A+ ++ + N+ + Sbjct: 134 NPEGSGRNMSLFLVMKRYDC-TLKEYL-RDKTPNMRSSILLLSQLLEAVAHM-NIHNISH 190 Query: 273 RDLKLENLMLD-----KDGHIKITDFGLCKEGIKDGATM------KTFCGTPEYLAPEVL 321 RDLK +N+++D I ITDFG C ++G + + G +APE+ Sbjct: 191 RDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIA 250 Query: 322 EDNDYG------RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI-RFPRTLGP 374 + D W +G + YE+ PFY++ + L + E++ P T+ Sbjct: 251 NAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPELPDTIPF 310 Query: 375 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413 ++L+S +L + +RL A + Q +A W Sbjct: 311 IIRNLVSNMLSRSTNKRLDCDV--AATVAQLYLWAPSSW 347 >4I94-A nrPDB Length = 300 Score = 113 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 44/237 (18%), Positives = 86/237 (36%), Gaps = 16/237 (6%) Query: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222 V K R A+K ++ + + L E + + R+ + L + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRK---SWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 223 LCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENL 280 + E+ L HL + I AL+Y S+ +Y DL + Sbjct: 100 RLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 281 MLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMY 340 + D D + +++ FGL K + TP PE L + G ++ Sbjct: 160 LFDDDANPRLSCFGLMKNSRDGKSYSTNLAFTP----PEYLRTGRVTPESVIYSFGTLLL 215 Query: 341 EMMCGR--LPFYNQD--HEKLFELILMEEIR--FPRTLGPEAKSLLSGLLKKDPKQR 391 +++ G+ P + D ++ ++++ + F G E L S L+ +P++R Sbjct: 216 DLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRER 272 >6J6I-B nrPDB Length = 351 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 40/192 (20%), Positives = 73/192 (38%), Gaps = 11/192 (5%) Query: 167 VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL--QNSRHPFLTALKYSFQTHDRLC 224 + + R Y +K ++ I K + + VL + S H L Sbjct: 75 YRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPV 134 Query: 225 FVMEYANGGELFFH-----LSRERVFSEDRARFYGAEIVSALDYLHSE--KNVVYRDLKL 277 V E+A G + E + G EI +A+ YLH+ K +++RD+K Sbjct: 135 LVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKP 194 Query: 278 ENLMLDKDGHIKITD--FGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL 335 ++ LDK+ K++D F + K + GT Y+ P + D + Sbjct: 195 MHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSF 254 Query: 336 GVVMYEMMCGRL 347 G+ + ++ G+ Sbjct: 255 GICLLVIITGKP 266 >5UU1-A nrPDB Length = 324 Score = 91.9 bits (227), Expect = 6e-19, Method: Composition-based stats. Identities = 53/246 (21%), Positives = 86/246 (34%), Gaps = 32/246 (13%) Query: 133 EMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA---MKI--------- 180 M K + N++ K +G G FG + L A +K+ Sbjct: 1 SMPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLF 60 Query: 181 --LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYS----FQTHDRLCFVMEYANGGE 234 LK VAK + E + + + S F+ VME G + Sbjct: 61 SELKFYQRVAKKDCIKKWIER---KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GID 116 Query: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD--KDGHIKITD 292 L + F + G ++ L+Y+H E V+ D+K NL+L + + D Sbjct: 117 LQKISGQNGTFKKSTVLQLGIRMLDVLEYIH-ENEYVHGDIKAANLLLGYKNPDQVYLAD 175 Query: 293 FGLCKEGIKDGAT-------MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 345 +GL +G K GT E+ + + + R D LG M +CG Sbjct: 176 YGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCG 235 Query: 346 RLPFYN 351 +LP+ Sbjct: 236 KLPWEQ 241 >5CLR-A nrPDB Length = 451 Score = 84.6 bits (208), Expect = 9e-17, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 83/238 (34%), Gaps = 32/238 (13%) Query: 165 ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR-- 222 V G+ Y +K +K + + + E L L +F Sbjct: 96 FKVYALDDGKTYFLKSVKIDA----ESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQV 146 Query: 223 LCFVMEYANGGELFFHLS------RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLK 276 + + G +L + + + F E + + H E +++RDLK Sbjct: 147 HYILTTFIKGIDLSRYKNALPLNVNLKHFWE--VLGIMISVCHQVKQFH-ELGLIHRDLK 203 Query: 277 LENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND---YGRAVDWW 333 N+MLD D + DFG D GT YLAPE+ D + + D + Sbjct: 204 PGNIMLDADMQCHLVDFGSS---SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLF 260 Query: 334 GLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQR 391 L + E+ PF K+ I + + L E ++ ++GL+ + R Sbjct: 261 ALAYSLDELFN---PFRQVKFAKVDIGIKNKHLVL---LHAEIEACITGLMSNETSVR 312 >6EAS-A nrPDB Length = 308 Score = 84.2 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 47/265 (17%), Positives = 83/265 (31%), Gaps = 37/265 (13%) Query: 159 GTFGKVILVKEK-ATGRYYAMK--ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 215 G+ +L K ++G A+ ++ +K+ + + L H L Sbjct: 49 GSTSTCMLYKGTLSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLG 108 Query: 216 SFQTHDRL--CFVMEYANGGELFFHLS--RERVFSEDRARFYGAEIVSALDYLHS-EKNV 270 + V EYA G LF HL I L+++H + Sbjct: 109 YCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPA 168 Query: 271 VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP--EVLEDNDYGR 328 R+ + L D K++D + +T +P E + Sbjct: 169 ALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELAF----SPDMEDIVRK---- 220 Query: 329 AVDWWGLGVVMYEMMCGRLPFYNQD-------------HEKLFELILMEEIRFPRTLGPE 375 G+V+ E++ GR+P D +L ELI FP Sbjct: 221 ------YGMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARA 274 Query: 376 AKSLLSGLLKKDPKQRLGGGSEDAK 400 ++ + +DPK+R A+ Sbjct: 275 LCEVVRSCIDRDPKKRPQMKEVAAR 299 >4O1O-A nrPDB Length = 717 Score = 80.4 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 46/255 (18%), Positives = 85/255 (33%), Gaps = 56/255 (21%) Query: 173 GRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYAN 231 + A+K + + E LQ+SR + + S L + Sbjct: 369 DQEVAVKRFSEGSTRGQ-------QEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCE 421 Query: 232 GGELFFHLSRERV-----FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286 L HL+ R ++ AR + + A+ LH ++DL+ +N+++D Sbjct: 422 Y-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELH-RSGYSHQDLQPQNILIDSKN 479 Query: 287 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG-VVMYEMMCG 345 + DF + +D +K D LG +V+Y + G Sbjct: 480 GTFLADFDKSIKWAEDPQKIKR----------------------DLEALGLLVLYVVKKG 517 Query: 346 RLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK--DPKQRLGGGSEDAKEIM 403 + F ++ E+I P E + L+ L + + RL ++ Sbjct: 518 DISFETLKNQSFEEVIQGS----PD---EETRDLIHHLFHPGDNVEDRLSS-------LL 563 Query: 404 QHRFFAGIVWQHVYE 418 H FF W+ Y Sbjct: 564 AHPFFWS--WESRYR 576 >2RSV-A nrPDB Length = 403 Score = 78.8 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 99/277 (35%), Gaps = 52/277 (18%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYY------AMKILKKE------------VIVAK 189 E++ +G+G FG + L + + +K+ + Sbjct: 42 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 100 Query: 190 DEVAHTLTENRVLQNSRHPFLTALKYSFQTHD----RLCFVMEYANGGELFF-HLSRERV 244 +++ + + ++ + S +M+ G +L + + + Sbjct: 101 EQIQKWIR----TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKIYEANAKR 155 Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD--KDGHIKITDFGLC------ 296 FS I+ L+Y+H E V+ D+K NL+L+ + + D+GL Sbjct: 156 FSRKTVLQLSLRILDILEYIH-EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 214 Query: 297 ---KEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353 KE +D GT E+ + + R D LG M + + G LP+ +D Sbjct: 215 GVHKEYKEDPKRCHD--GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--ED 270 Query: 354 HEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQ 390 + K + + +IR+ + SL+ P++ Sbjct: 271 NLKDPKYVRDSKIRYRENI----ASLMDKCF---PEK 300 >2LAV-A nrPDB Length = 361 Score = 78.5 bits (192), Expect = 6e-15, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 99/277 (35%), Gaps = 52/277 (18%) Query: 148 NEFEYLKLLGKGTFGKVILVKEKATGRYY------AMKILKKE------------VIVAK 189 E++ +G+G FG + L + + +K+ + Sbjct: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 Query: 190 DEVAHTLTENRVLQNSRHPFLTALKYSFQTHD----RLCFVMEYANGGELFF-HLSRERV 244 +++ + + ++ + S +M+ G +L + + + Sbjct: 94 EQIQKWIR----TRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKIYEANAKR 148 Query: 245 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD--KDGHIKITDFGLC------ 296 FS I+ L+Y+H E V+ D+K NL+L+ + + D+GL Sbjct: 149 FSRKTVLQLSLRILDILEYIH-EHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE 207 Query: 297 ---KEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 353 KE +D GT E+ + + R D LG M + + G LP+ +D Sbjct: 208 GVHKEYKEDPKRCHD--GTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPW--ED 263 Query: 354 HEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQ 390 + K + + +IR+ + SL+ P++ Sbjct: 264 NLKDPKYVRDSKIRYRENI----ASLMDKCF---PEK 293 >5DMZ-A nrPDB Length = 365 Score = 75.0 bits (183), Expect = 7e-14, Method: Composition-based stats. Identities = 36/214 (16%), Positives = 82/214 (38%), Gaps = 27/214 (12%) Query: 155 LLGKGTFGKVILVK-----EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 LLG+G F +V + + + +K+ +K + + L E R+ + +H F Sbjct: 72 LLGEGAFAQVYEATQGDLNDAKNKQKFVLKV-QKPANPWEFYIGTQLME-RLKPSMQHMF 129 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLS-----RERVFSEDRARFYGAEIVSALDYL 264 + + V E + G L ++ E+V + + ++ ++ + Sbjct: 130 -MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQV 188 Query: 265 HSEKNVVYRDLKLENLMLDKDGH-----------IKITDFGLCKEG--IKDGATMKTFCG 311 H + +++ D+K +N +L + + D G + G C Sbjct: 189 H-DCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCE 247 Query: 312 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 345 T + E+L + + +D++G+ +Y M+ G Sbjct: 248 TSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFG 281 >4OAU-C nrPDB Length = 699 Score = 74.6 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 45/242 (18%), Positives = 78/242 (32%), Gaps = 47/242 (19%) Query: 173 GRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYAN 231 + A+K + E LQ+SR + L S L + Sbjct: 366 KQEVAVKTFCEGSP-------RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE 418 Query: 232 GG---ELFFHLSRERVFSEDR-ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287 L H + ED AR + I A+ LH ++DL+ +N+++D Sbjct: 419 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 478 Query: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG-VVMYEMMCGR 346 + DF + D +K D LG +V+Y + G Sbjct: 479 AHLADFDKSIKWAGDPQEVKR----------------------DLEDLGRLVLYVVKKGS 516 Query: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406 + F + + E++ + P E K L+ L R + +++ H Sbjct: 517 ISFEDLKAQSNEEVVQLS----PD---EETKDLIHRLFHPGEHVR-----DCLSDLLGHP 564 Query: 407 FF 408 FF Sbjct: 565 FF 566 >4IX6-A nrPDB Length = 350 Score = 70.4 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 57/338 (16%), Positives = 95/338 (28%), Gaps = 89/338 (26%) Query: 145 VTMNEFEYL-KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203 V + L LG G FG V K + +K K +V+ A++ + + N Sbjct: 16 VEPKDIRVLPGPLGSGNFGTVFRGVFKGD-QDVVLKNAKADVMAAEELLECEMDVNY--- 71 Query: 204 NSRHPF----LTALKYSFQ----THDRLCF--VME----------------YANGGE--L 235 H + + + E G L Sbjct: 72 -HVHANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPL 130 Query: 236 FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK--DGHIKITDF 293 ++ + E++ +L LH E VV+RD+K NL+ + G +K+ D Sbjct: 131 ATAMACADATELGVTKKAMRELLGSLARLH-ECGVVHRDVKPANLIAAEKDGGVLKLIDL 189 Query: 294 GLCKEGIKDGATMKTFCG----TPEY--------LAP--------------EVLEDNDYG 327 G + T+ + G P Y L P E + + + Sbjct: 190 GAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRF- 248 Query: 328 RAVDWWGLGVVMYEMMC-------GRLPFYNQ-----DHEKLFELILMEEIRFPRTLGPE 375 D W G VM ++ G F F E + Sbjct: 249 ---DSWSAGCVMLQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALD 305 Query: 376 A-----KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408 A L L++ + R + + H FF Sbjct: 306 ANGGAGWDLCQRLMEAERDARASCEA-----ALSHAFF 338 >6M7Z-A nrPDB Length = 319 Score = 70.0 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 40/225 (17%), Positives = 81/225 (36%), Gaps = 33/225 (14%) Query: 208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 267 P L + +F L ++ + G + L R S + A +V+AL LH+ Sbjct: 111 PSLGEYRGAF-----LTYIFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHN- 162 Query: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV------- 320 +++R ++L + + DG + + + F G APE+ Sbjct: 163 LGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFFGQE--TAPEIDRNFLAD 220 Query: 321 --LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378 L + D + LGV ++ +L + + + + L Sbjct: 221 LALTQGRHTVKSDVYSLGVAFRNLV--QLLGNGNLGPEDRGAVRQDHLELLDKLS----- 273 Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSP 423 +++++P R +EIM+ F G+ ++ + E K P Sbjct: 274 --QKMIEEEPGNR-----PTIEEIMKDPLFEGLNFEDIEEGKARP 311 >6G4J-A nrPDB Length = 315 Score = 70.0 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 39/164 (23%), Positives = 65/164 (39%), Gaps = 25/164 (15%) Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201 K + N + K LGKG G V L E + G A+K+ D+ +E V Sbjct: 20 KGKWNGNTYTLRKQLGKGANGIVYLA-ETSDGH-VALKV--------SDDSLSITSEVNV 69 Query: 202 LQNSRHPFLTALKYSFQTHDRLCF----------VMEYANGGELFFHLSRERVFSEDRAR 251 L++ + SF D MEY G L ++S + + Sbjct: 70 LKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIP 126 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFG 294 +++S+L LH ++ ++ DLK +NL++ I+ D G Sbjct: 127 VLMIQLLSSLSVLH-QQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >6BHC-A nrPDB Length = 438 Score = 66.1 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 51/274 (18%), Positives = 92/274 (33%), Gaps = 53/274 (19%) Query: 176 YAMKILKKEVIVAKDE------VAHTLTENRVLQNSRH-----PFLTALKYSFQTHD--R 222 YA+KI K + ++ + Q+ H P Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 223 LCFVMEYANGGELFFHLS-------RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 + + + + + E + ++ S L++L +V + DL Sbjct: 146 VVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHL-KPYHVTHCDL 204 Query: 276 KLENLMLDK---DGHIK------------------ITDFGLCKEGIK--DGATMKTFCGT 312 +LENL+L G + +++F K+ D ++ Sbjct: 205 RLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR- 263 Query: 313 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP--R 370 LAPE++ Y + D + G+++YEM+ PF K E + R P Sbjct: 264 ---LAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRS 319 Query: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 + L S LL +P +R+ DAK I+Q Sbjct: 320 PYSRGLQQLASCLLNPNPSERI--LISDAKGILQ 351 >5GZA-A nrPDB Length = 290 Score = 63.4 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 43/218 (19%), Positives = 72/218 (33%), Gaps = 52/218 (23%) Query: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210 +KL+G+G KV L + + G+ A+ V+ + L +L+ + + Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVAL-----SVLSSDQYADDFLHGLSMLRALQSSHV 80 Query: 211 TALKYSFQTHDRLCFVMEYANGGELFFH---LSRERVF---SEDRARFYGAEIVSALDYL 264 L + FV EY G + L++ER S + V+ L YL Sbjct: 81 VTLVGVCEED--AVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYL 138 Query: 265 HS---------EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---- 311 HS + N +++ L +L D + L + K G Sbjct: 139 HSSPAGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKGGLGVKCG 190 Query: 312 ----TPEYLAPEVL------------EDNDYGRAVDWW 333 T +++APE L Y D W Sbjct: 191 HHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5GZ9-A nrPDB Length = 305 Score = 61.9 bits (149), Expect = 6e-10, Method: Composition-based stats. Identities = 40/217 (18%), Positives = 69/217 (31%), Gaps = 41/217 (18%) Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206 E LK +G+G +V L + K A+ + + L ++L++ + Sbjct: 33 RTEVRQLKRVGEGAVKRVFLSEWKE--HKVAL-----SRLTRLEMKEDFLHGLQMLKSLQ 85 Query: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFH-----LSRERVF-SEDRARFYGAEIVSA 260 + L + + EY G L LS+ + + E VS Sbjct: 86 SEHVVTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSI 143 Query: 261 LDYLHSEKNVVYRDLKLEN--------LMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT 312 ++YLH + R + N +L + I D + + + CG Sbjct: 144 INYLH-HSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDL-DALPLVDHDSGVLIKCGH 201 Query: 313 PE----YLAPEVL------------EDNDYGRAVDWW 333 E ++APE L Y VD W Sbjct: 202 RELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >6EWX-A nrPDB Length = 484 Score = 61.5 bits (148), Expect = 7e-10, Method: Composition-based stats. Identities = 41/201 (20%), Positives = 75/201 (37%), Gaps = 48/201 (23%) Query: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML------------------------ 282 E R F ++ + L++L E +++RDL LENL+L Sbjct: 209 ERRVCFLLLQLCNGLEHL-KEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRC 267 Query: 283 -----------------DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325 + I++F K+ ++ LAPE++ + Sbjct: 268 PSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQAR-LAPEIVSASQ 326 Query: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP--RTLGPEAKSLLSGL 383 Y R D + G+++YE++ PF + + + + P P + L L Sbjct: 327 Y-RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLL 385 Query: 384 LKKDPKQRLGGGSEDAKEIMQ 404 L+ DP +R+ G AK ++Q Sbjct: 386 LEADPIKRIRIGE--AKRVLQ 404 >2JII-A nrPDB Length = 352 Score = 61.1 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 30/142 (21%), Positives = 58/142 (40%), Gaps = 12/142 (8%) Query: 242 ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD--KDGHIKITDFGLCKEG 299 + V SE ++ AL++LH E V+ ++ EN+ +D + + +G Sbjct: 153 KHVLSERSVLQVACRLLDALEFLH-ENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRY 211 Query: 300 IKDGATMKTFCGTP-------EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ 352 G + G+ E+++ ++ + R D LG M + + G LP+ N Sbjct: 212 CPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNC 271 Query: 353 DHEKLFELILMEEIRFPRTLGP 374 E I+ ++ +F GP Sbjct: 272 LPN--TEDIMKQKQKFVDKPGP 291 >4CI6-B nrPDB Length = 643 Score = 58.8 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 41/257 (15%), Positives = 82/257 (31%), Gaps = 38/257 (14%) Query: 94 EEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYL 153 +E + I L + + SGA ++E + E Sbjct: 2 PTSQELRSDIPNALSNLFGAKPQTELPLGWKGKPLSGAPDLEGMRVAETDKFAEGESHI- 60 Query: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN-SRHPFLTA 212 + E + KI + I A + + +HP L Sbjct: 61 ------------SIIETKDKQRLVAKI--ERSIAEGHLFAELEAYKHIYKTAGKHPNLAN 106 Query: 213 LKY--SFQTHDRLC--FVMEYANG-------GELFFHLSRERVFSED---RARFYGAEIV 258 + +R +M+ +G L + ++ SE +F ++ Sbjct: 107 VHGMAVVPYGNRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLL 166 Query: 259 SALDYLHSEKNVVYRDLKLENLMLDK-DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317 ++L ++ +V+ D+K N++ D+ G + D GL + G K F T + A Sbjct: 167 DVTNHL-AKAGIVHNDIKPGNVVFDRASGEPVVIDLGL---HSRSGEQPKGF--TESFKA 220 Query: 318 PEV-LEDNDYGRAVDWW 333 PE+ + + D + Sbjct: 221 PELGVGNLGASEKSDVF 237 >6G38-A nrPDB Length = 357 Score = 55.3 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 31/183 (16%), Positives = 58/183 (31%), Gaps = 49/183 (26%) Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVI-----VAKDEVAHTLT 197 H + + + + +G+G FG+V T A+KI+ E + L Sbjct: 36 HCLPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILP 93 Query: 198 ENRVLQNS-----------------------------------RHPFLTA----LKYSFQ 218 E + + H T + F Sbjct: 94 EIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFF 153 Query: 219 THDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKL 277 D+L V+E+ GG +L R ++ S A+ ++ ++L + +RDL Sbjct: 154 KDDQLFIVLEFEFGGIDLEQM--RTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHW 211 Query: 278 ENL 280 N+ Sbjct: 212 GNV 214 >4CYJ-A nrPDB Length = 438 Score = 53.0 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 58/148 (39%), Gaps = 21/148 (14%) Query: 161 FGK---VILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSF 217 FG V + GR+YA++ L+ + + + + + + + ++ + + F Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKD---WKKIKNASIVTIHEVF 121 Query: 218 QTHD----RLCFVMEYANGG-ELFFH----LSRERV-----FSEDRARFYGAEIVSALDY 263 T + L F ++ L H + R E+ Y +I +AL Sbjct: 122 TTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKT 181 Query: 264 LHSEKNVVYRDLKLENLMLDKDGHIKIT 291 +HS + + R L+ ++L I+++ Sbjct: 182 IHSNR-LAARCLEPSKIILTDINRIRLS 208 >3BYV-A nrPDB Length = 377 Score = 52.6 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 36/169 (21%), Positives = 69/169 (40%), Gaps = 20/169 (11%) Query: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 L H S + +++ L LH +V+ L+ +++LD+ G + +T F Sbjct: 193 LLSHSSTHKSLVHHARLQLTLQVIRLLASLH-HYGLVHTYLRPVDIVLDQRGGVFLTGF- 250 Query: 295 LCKEGIKDGATMKTFCGTPEYLAPEV------LEDND-----YGRAVDWWGLGVVMYEMM 343 + ++DGA + + + + PE+ + + + D W LG+V+Y + Sbjct: 251 --EHLVRDGARVVSSV-SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIW 307 Query: 344 CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 C LP E I P+ + ++LL G L+ + RL Sbjct: 308 CADLPITKDAALGGSEWIFRSCKNIPQPV----RALLEGFLRYPKEDRL 352 >4CZY-B nrPDB Length = 429 Score = 52.3 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 56/142 (39%), Gaps = 20/142 (14%) Query: 165 ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTH---- 220 + GR++A++ ++ + + + + E + + + + +F T Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKE---WKKIINANIVTVHEAFTTEFFGD 117 Query: 221 DRLCFVMEYANGGE-LFFH----------LSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 L FV ++ E L+ H L E+ Y +I +AL +H+ K Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAK- 176 Query: 270 VVYRDLKLENLMLDKDGHIKIT 291 + R L+L ++ ++ I++ Sbjct: 177 LAARCLELSKIIW-ENNRIRLA 197 >2W1Z-A nrPDB Length = 368 Score = 51.5 bits (122), Expect = 8e-07, Method: Composition-based stats. Identities = 37/171 (21%), Positives = 67/171 (39%), Gaps = 19/171 (11%) Query: 232 GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKIT 291 G L H S + +++ L +V+ D ++ N++LD+ G + +T Sbjct: 175 GDVLLSHSSTHKSLVHHARLQLTLQLIRLAASL-QHYGLVHADFQVRNILLDQRGGVFLT 233 Query: 292 DFGLCKEGIKDGATMKTFCGTPEYLAPE-----VLEDNDY-----GRAVDWWGLGVVMYE 341 F + ++DGA+ + G + PE +L + D W LG+ +Y Sbjct: 234 GF---EHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYW 289 Query: 342 MMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 + C LP E I P+ + ++LL G L+ + RL Sbjct: 290 IWCADLPNTEDAELGGIEWIYRRCKNIPQPV----RALLEGFLRYSKEDRL 336 >4AZW-A nrPDB Length = 471 Score = 51.5 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 30/71 (42%), Gaps = 4/71 (5%) Query: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283 VME G L L+ E ++ +L L +K + D++ N+M+D Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAAL-EKKGFWHDDVRPWNVMVD 373 Query: 284 KDGHIKITDFG 294 H ++ DFG Sbjct: 374 ARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 50.7 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 17/71 (23%), Positives = 29/71 (40%), Gaps = 4/71 (5%) Query: 224 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 283 VME G L L+ E ++ +L L + + D++ N+M+D Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKQ-GFWHDDVRPWNVMVD 373 Query: 284 KDGHIKITDFG 294 H ++ DFG Sbjct: 374 ARQHARLIDFG 384 >3DZO-A nrPDB Length = 413 Score = 50.3 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 37/168 (22%), Positives = 66/168 (39%), Gaps = 19/168 (11%) Query: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 L H S + +++ L LH +V+ L+ +++LD+ G + +T F Sbjct: 198 LLSHSSTHKSLVHHARLQLTLQVIRLLASLH-HYGLVHTYLRPVDIVLDQRGGVFLTGF- 255 Query: 295 LCKEGIKDGATMKTFCGTPEYLAPE----------VLEDNDYGRAVDWWGLGVVMYEMMC 344 + ++DGA+ + G + PE A D W LG+ +Y + C Sbjct: 256 --EHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWC 312 Query: 345 GRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRL 392 LP + E I P+ + ++LL G L+ + RL Sbjct: 313 ADLPNTDDAALGGSEWIFRSCKNIPQPV----RALLEGFLRYPKEDRL 356 >6R5K-O nrPDB Length = 689 Score = 49.6 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 21/137 (15%), Positives = 52/137 (37%), Gaps = 13/137 (9%) Query: 165 ILVKEKATGRYYAMKIL-KKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHD-- 221 V G+ Y +K L + + ++++ ++ L + FQT Sbjct: 311 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIY---QIWSKINCTNLIKFRDIFQTTKFG 367 Query: 222 --RLCFVMEYANGG-ELFFHLS---RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 +C V +Y L+ + + + + Y ++ + ++ +HS+ + L Sbjct: 368 DLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTL 427 Query: 276 KLENLMLDKD-GHIKIT 291 +++ D G IK++ Sbjct: 428 NWRKVLITGDPGRIKLS 444 >3ENH-A nrPDB Length = 540 Score = 49.2 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 35/161 (21%), Positives = 55/161 (34%), Gaps = 18/161 (11%) Query: 155 LLGKGTFGKVILVKEKATGRYYAMK-ILKK----EVIVAKDEVAHTLTENRVLQNSRHPF 209 L+GKG + ++ +K +KK E + + T E R L + Sbjct: 343 LIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFG 400 Query: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 + A D +M Y NG + +I + LH + + Sbjct: 401 IPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDN--------LDIAYKIGEIVGKLH-KND 451 Query: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC 310 V++ DL N + DKD + I DFGL K D Sbjct: 452 VIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAVDLI 490 >4XR7-L nrPDB Length = 465 Score = 48.8 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 21/137 (15%), Positives = 52/137 (37%), Gaps = 13/137 (9%) Query: 165 ILVKEKATGRYYAMKIL-KKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHD-- 221 V G+ Y +K L + + ++++ ++ L + FQT Sbjct: 87 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIY---QIWSKINCTNLIKFRDIFQTTKFG 143 Query: 222 --RLCFVMEYANGG-ELFFHLS---RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL 275 +C V +Y L+ + + + + Y ++ + ++ +HS+ + L Sbjct: 144 DLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTL 203 Query: 276 KLENLMLDKD-GHIKIT 291 +++ D G IK++ Sbjct: 204 NWRKVLITGDPGRIKLS 220 >5VE6-A nrPDB Length = 492 Score = 47.3 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 5/91 (5%) Query: 316 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP--RTLG 373 LAPE++ + Y R D + G+++YE++ PF + + + + P Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPALSLYS 383 Query: 374 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 404 P + L LL+ DP +R+ G AK ++Q Sbjct: 384 PGLQQLAHLLLEADPIKRIRIGE--AKRVLQ 412 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 14/36 (38%), Positives = 23/36 (63%), Gaps = 1/36 (2%) Query: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282 E R F ++ + L++L E +++RDL LENL+L Sbjct: 207 ERRVCFLLLQLCNGLEHL-KEHGIIHRDLCLENLLL 241 >3Q60-A nrPDB Length = 371 Score = 44.6 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 54/307 (17%), Positives = 97/307 (31%), Gaps = 60/307 (19%) Query: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT----LTENRVLQN 204 + + ++ L G V LV++ +A+K+ ++ E+ R+L Sbjct: 63 KLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLGE 122 Query: 205 S--------------------RHPFLTAL---KYSFQTHDRLCFV------MEYANGGEL 235 S P L + + + L + +E Sbjct: 123 SPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTLD 182 Query: 236 FFHLSRERVFSEDRARF--YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF 293 F ++ R E A+++ L S K +V+ +NL + DG + + D Sbjct: 183 FVYVFRG---DEGILALHILTAQLIRLAANLQS-KGLVHGHFTPDNLFIMPDGRLMLGD- 237 Query: 294 GLCKEGIKDGATMKTFCGTPEYLAPEVLEDN--DYGRAVDWWGLGVVMYEMMCGRLPFYN 351 K G Y E L + + A++ W LG+ +Y + C LPF Sbjct: 238 --VSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF-G 294 Query: 352 QDHEKLFELILMEEIRFP----------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKE 401 + +R P L K+L+ L D ++RL E Sbjct: 295 LVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPL-----E 349 Query: 402 IMQHRFF 408 M+ F Sbjct: 350 AMETPEF 356 >4OTP-A nrPDB Length = 352 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 32/167 (19%), Positives = 57/167 (34%), Gaps = 31/167 (18%) Query: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH--- 207 E + G V A G A+KI K ++V KD + E R RH Sbjct: 39 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFR----FRHGYC 93 Query: 208 ----------------PFLTALKYS-FQTHDRLCF-----VMEYANGGELFFHLSRERVF 245 L L + + + VM + ++ L + Sbjct: 94 KGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQL 153 Query: 246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITD 292 SE +AR +++ + ++ + +V+ DL N++ G + I D Sbjct: 154 SESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-HGGGVYIID 199 >6G5I-z nrPDB Length = 568 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 32/167 (19%), Positives = 57/167 (34%), Gaps = 31/167 (18%) Query: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH--- 207 E + G V A G A+KI K ++V KD + E R RH Sbjct: 181 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFR----FRHGYC 235 Query: 208 ----------------PFLTALKYS-FQTHDRLCF-----VMEYANGGELFFHLSRERVF 245 L L + + + VM + ++ L + Sbjct: 236 KGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQL 295 Query: 246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITD 292 SE +AR +++ + ++ + +V+ DL N++ G + I D Sbjct: 296 SESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-HGGGVYIID 341 >1TQM-A nrPDB Length = 282 Score = 43.8 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 33/156 (21%), Positives = 56/156 (35%), Gaps = 27/156 (17%) Query: 152 YLKLLGKGTFGKVILVKEKATGRYYAM---------KILKKEVIVAKDE-----VAHTLT 197 KL+G+G V + G K +K++ + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 198 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257 E R LQ + A+ + ME + EL+ R RV + D E Sbjct: 154 EFRALQKLQG---LAVPKVYAWEGNAVL-MELIDAKELY----RVRVENPDEVLDMILEE 205 Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF 293 V+ + H + +V+ DL N+++ ++G I I DF Sbjct: 206 VA--KFYH--RGIVHGDLSQYNVLVSEEG-IWIIDF 236 >3VIA-A nrPDB Length = 112 Score = 43.8 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 18/67 (26%), Positives = 35/67 (52%), Gaps = 2/67 (2%) Query: 4 VAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQD--VDQREAPLNNFSVAQCQ 61 +A VK GWL ++ +K W+ +F L +DG I Y ++ + D+ P++ ++ Q Sbjct: 3 MAFVKSGWLLRQSTILKRWKKNWFDLWSDGHLIYYDDQTRQNIEDKVHMPMDCINIRTGQ 62 Query: 62 LMKTERP 68 + +P Sbjct: 63 ECRDTQP 69 >4BWP-A nrPDB Length = 448 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 19/167 (11%), Positives = 42/167 (25%), Gaps = 44/167 (26%) Query: 165 ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTH---- 220 TG K + + + + +T + + +H + L+ F T Sbjct: 67 YRATHNTTGY----KYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGD 122 Query: 221 DRLCFVMEYANGG-------------------------------ELFFHLSRERVFSEDR 249 + L V +Y G S + E Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH----IKITD 292 ++ + L +H + + L +++ I+D Sbjct: 183 IWSIIMQLTAGLKAIH-HAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >2DHI-A nrPDB Length = 120 Score = 43.4 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 40/77 (51%), Gaps = 5/77 (6%) Query: 7 VKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQD--VDQREAPLNNFSVA---QCQ 61 VK GWL ++ +K W+ +F L +DG I Y ++ + D+ P++ ++ +C+ Sbjct: 9 VKSGWLLRQSTILKRWKKNWFDLWSDGHLIYYDDQTRQSIEDKVHMPVDCINIRTGHECR 68 Query: 62 LMKTERPRPNTFIIRCL 78 ++ +P +++ + Sbjct: 69 DIQPPDGKPRDCLLQIV 85 >4WWA-A nrPDB Length = 261 Score = 41.5 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 52/150 (34%), Gaps = 21/150 (14%) Query: 165 ILVKEKATGRYYAMK-----ILKKEVIVAKDEVAHTLTENRVLQNSR---HPFLTALKYS 216 L + K + + Y +K + I TL E+R+L + L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 217 FQTHDRLCFVM--EYANGG----EL--FFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 268 + + E GG L F + + +S D ++ + LH Sbjct: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS-DLVATTLRKVGRQIGLLH-WN 155 Query: 269 NVVYRDLKLENLMLDKDG---HIKITDFGL 295 + + DL N++L +DG + DFGL Sbjct: 156 DYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >1V5U-A nrPDB Length = 117 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 21/107 (19%), Positives = 44/107 (41%), Gaps = 10/107 (9%) Query: 9 EGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERP 68 EG L+K+G ++K W+ R+F+L + Y + D + + +A+ + + P Sbjct: 11 EGILYKKGAFMKPWKARWFVLDKTKHQLRYYDHRMDTECKGV----IDLAEVEAVAPGTP 66 Query: 69 R---PNTFIIRCLQWTTVIERTFH--VETPEEREEWTTAIQ-TVADG 109 P T + R ++ + ++W IQ ++ G Sbjct: 67 TIGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSSG 113 >5YK0-A nrPDB Length = 452 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 29/171 (16%), Positives = 48/171 (28%), Gaps = 43/171 (25%) Query: 162 GKVILVKEKATGRYYAMKI-LKKEVIVAKDEVAHTLTENRVLQNS----RHPFLT----- 211 G+V + GR A+KI + ++ VL+ + Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 212 ----------------ALKYSFQTHDRL-----------CFVMEYANGGELFFHLSRERV 244 A ++ H R + E+ G + + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 245 FSEDRARFYGAEI-VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294 D AE+ A L +++ D N ML DG + I DFG Sbjct: 265 EQRDLIGTLLAELTFDAPRRL----GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >2D9V-A nrPDB Length = 130 Score = 37.6 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 24/44 (54%), Gaps = 1/44 (2%) Query: 6 IVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERP-QDVDQR 48 +V+ GWL ++ ++ W+ +F L DGT Y + QD + R Sbjct: 8 LVRGGWLWRQSSILRRWKRNWFALWLDGTLGYYHDETAQDEEDR 51 >6G18-v nrPDB Length = 552 Score = 37.6 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 20/76 (26%), Positives = 30/76 (39%), Gaps = 9/76 (11%) Query: 219 THDRLCFVMEYANGGELFFHLSRERVFSE-DRARFYGAEIVSALDYLHSEKNVVYRDLKL 277 ++R VME NG L E S D A ++ +++ D Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA--------NHGLIHGDFNE 231 Query: 278 ENLMLDKDGHIKITDF 293 NL+LD+ HI + DF Sbjct: 232 FNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 37.2 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 20/76 (26%), Positives = 30/76 (39%), Gaps = 9/76 (11%) Query: 219 THDRLCFVMEYANGGELFFHLSRERVFSE-DRARFYGAEIVSALDYLHSEKNVVYRDLKL 277 ++R VME NG L E S D A ++ +++ D Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA--------NHGLIHGDFNE 231 Query: 278 ENLMLDKDGHIKITDF 293 NL+LD+ HI + DF Sbjct: 232 FNLILDESDHITMIDF 247 >4H6Y-A nrPDB Length = 501 Score = 36.1 bits (82), Expect = 0.034, Method: Composition-based stats. Identities = 29/146 (19%), Positives = 55/146 (37%), Gaps = 12/146 (8%) Query: 7 VKEGWLHKRGEYIKTWRPRYFLLKNDGTFI---GYKERPQDVDQREAPLNNFSVAQCQLM 63 ++ G L K K + R F L ND G Q + PL ++ + + Sbjct: 227 IRLGSLSKLSG--KGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESED- 283 Query: 64 KTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSG 123 E P+ +R + + ++ + E E+W IQ D +K +F + Sbjct: 284 --EWGVPHCLTLRGQRQSIIV----AASSRSEMEKWVEDIQMAIDLAEKSSSPAPEFLAS 337 Query: 124 SPSDNSGAEEMEVSLAKPKHRVTMNE 149 SP DN +E + + + ++ + Sbjct: 338 SPPDNKSPDEATAADQESEDDLSASR 363 >6E31-A nrPDB Length = 359 Score = 34.9 bits (79), Expect = 0.082, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 38/75 (50%), Gaps = 10/75 (13%) Query: 9 EGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRE----APLNNFSVA---QCQ 61 EG L+ + + K+W+ RYFLL+ G + Y + + R+ N ++ QC+ Sbjct: 239 EGALYLKEDGKKSWKRRYFLLRASGIY--YVPKGKTKTSRDLACFIQFENVNIYYGIQCK 296 Query: 62 LMKTERPRPNTFIIR 76 MK + P + F+++ Sbjct: 297 -MKYKAPTDHCFVLK 310 >3TCA-A nrPDB Length = 291 Score = 34.5 bits (78), Expect = 0.091, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 38/75 (50%), Gaps = 10/75 (13%) Query: 9 EGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRE----APLNNFSVA---QCQ 61 EG L+ + + K+W+ RYFLL+ G + Y + + R+ N ++ QC+ Sbjct: 171 EGALYLKEDGKKSWKRRYFLLRASGIY--YVPKGKTKTSRDLACFIQFENVNIYYGIQCK 228 Query: 62 LMKTERPRPNTFIIR 76 MK + P + F+++ Sbjct: 229 -MKYKAPTDHCFVLK 242 >1ZP9-A nrPDB Length = 258 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 29/203 (14%), Positives = 57/203 (28%), Gaps = 35/203 (17%) Query: 155 LLGKGTFGKVILVKEKATGRYYA--MKILKKEVIVAKDEVAHTLTENR------------ 200 ++ G V G+ A +KI + E + + R Sbjct: 54 VISTGKEANVFYADGVFDGKPVAMAVKIYRIETSEFDKMDEYLYGDERFDMRRISPKEKV 113 Query: 201 -VLQNSRHPFLTALKYSFQTHDRLC------FVMEYANGGELF--FHLSRERVFSEDRAR 251 + L K + + + +ME+ EL + R E Sbjct: 114 FIWTEKEFRNLERAKEAGVSVPQPYTYMKNVLLMEFIGEDELPAPTLVELGRELKELDVE 173 Query: 252 FYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC---KEGIKDGATMKT 308 ++V + L+ E +V+ DL N+M + D G + + + + Sbjct: 174 GIFNDVVENVKRLYQEAELVHADLSEYNIMYID--KVYFIDMGQAVTLRHPMAESYLERD 231 Query: 309 FCGTPEYLAPEVLEDNDYGRAVD 331 + + YG D Sbjct: 232 VRNIIRF-------FSKYGVKAD 247 >4GZU-A nrPDB Length = 501 Score = 33.8 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 37/103 (35%), Gaps = 6/103 (5%) Query: 10 GWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPR 69 G+L ++ + W+ + + N F YK D PL +SV+ L + Sbjct: 404 GYLLRKFKNSNGWQKLWVVFTNFCLFF-YKTHQDDYPLASLPLLGYSVS---LPREADSI 459 Query: 70 PNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKK 112 ++ + + V F E+ E W I+ + + Sbjct: 460 HKDYVFKLQFKSHVYF--FRAESKYTFERWMDVIKRASSSPGR 500 >4A6K-A nrPDB Length = 120 Score = 33.8 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 37/66 (56%), Gaps = 5/66 (7%) Query: 7 VKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTE 66 +K G+L +R +++K++ Y++L + ++ + D + P+ + ++++C + TE Sbjct: 7 IKSGFLERRSKFLKSYSKGYYVLTPNFL---HEFKTADRKKDLVPVMSLALSECTV--TE 61 Query: 67 RPRPNT 72 R N+ Sbjct: 62 HSRKNS 67 >4BVU-A nrPDB Length = 211 Score = 33.4 bits (75), Expect = 0.21, Method: Composition-based stats. Identities = 25/185 (13%), Positives = 58/185 (31%), Gaps = 24/185 (12%) Query: 152 YLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLT 211 KL+G+G+ ++ ++ Y K + + E+ + Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESELFNAFYGD--- 97 Query: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271 Q + M G L + + D +++ L+ E +++ Sbjct: 98 EASVVIQYGGDVYLRMLRVPGTPLSDIDTAD---IPDNIESLYLQLICKLN----ELSII 150 Query: 272 YRDLKLENLMLDKDGH-IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330 + DL N++ DK+ + DF + + E+++ R Sbjct: 151 HYDLNTGNMLYDKESESLFPIDF---RNIYAEYYAATKKDK-------EIIDRRLQMRTN 200 Query: 331 DWWGL 335 D++ L Sbjct: 201 DFYSL 205 >5GQY-A nrPDB Length = 793 Score = 33.0 bits (74), Expect = 0.33, Method: Composition-based stats. Identities = 34/235 (14%), Positives = 75/235 (31%), Gaps = 46/235 (19%) Query: 12 LHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPN 71 L + G+ K W R +L K + ++ RP +++E P+N+ E P N Sbjct: 49 LLEEGKNTKKWVVRAYLPKAEAAWVI---RPT--ERKEDPMNSVHHPNFFECIIETPELN 103 Query: 72 TFIIRCLQWTT--VIERTFHVETPEEREE---------WTTAIQTVADGLKKQEEEEMDF 120 + ++ + VI + +P +E + + + + + + Sbjct: 104 HYQLKVKEGEHEKVIYDPYAFSSPYLTDEDIYLFSEGNHHRIYEKLGAHVGEINGVKGVY 163 Query: 121 RSGSPSDNSGAEEME--VSLAKPKHRVTMNEFEYLKL----LGKGTFGKVILVKEKATGR 174 + + + + +H++ + +L +G GT V + K + Sbjct: 164 FAVWAPNARNVSVIGDFNNWDGREHQMRKRNYTIWELFVPEIGSGT---VYKYEIKNS-- 218 Query: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF----LTALKYSFQTHDRLCF 225 + I K + E R P + + +Q HD Sbjct: 219 --------EGHIYEKSDPYGFYREVR-------PNTASIVVDIDNIYQWHDEEWL 258 >3LV4-A nrPDB Length = 456 Score = 32.6 bits (73), Expect = 0.36, Method: Composition-based stats. Identities = 8/43 (18%), Positives = 16/43 (37%) Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED 248 +HP + F + +L V +GG + ++ F Sbjct: 142 KHPNVVDPHTFFDQNGKLWMVYGSYSGGIFILEMDKKTGFPLP 184 >4IFQ-A nrPDB Length = 970 Score = 31.8 bits (71), Expect = 0.74, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 31/97 (31%), Gaps = 8/97 (8%) Query: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239 IL + +V + L +LQ F+ F L E G L ++ Sbjct: 94 ILSGDTTANNGKVQYFLRRQYILQIVS--FIVN---CFHEDTELY--QELIKNGALVSNI 146 Query: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLK 276 F + +I A L + + +++K Sbjct: 147 LSAFKFIHTQLSEIKQQINKA-QILENYNALFQQNIK 182 >2QG7-A nrPDB Length = 458 Score = 31.5 bits (70), Expect = 0.87, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 31/90 (34%), Gaps = 11/90 (12%) Query: 179 KILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238 K L + DE+ + E ++ + + Y F T+ R + E+ +G L Sbjct: 135 KYLIRLYGPKTDEIINREREKKISCILYNKNIAKKIYVFFTNGR---IEEFMDGYALSRE 191 Query: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEK 268 + F + I L LH K Sbjct: 192 DIKNPKFQKL--------IAKNLKLLHDIK 213 >6GK6-A nrPDB Length = 411 Score = 31.5 bits (70), Expect = 0.94, Method: Composition-based stats. Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 9/83 (10%) Query: 28 LLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERT 87 LLK+ +++ P +V +R PL++ + Q M P P+ +R +++R Sbjct: 56 LLKDPRLIRDFRKLPDEVRRRYFPLSDRTTFMDQHMLDADP-PDHTRLRA-----IVQRA 109 Query: 88 FHVETPEEREEWTTAIQTVADGL 110 F +P E IQ +ADGL Sbjct: 110 F---SPRMMEGLRPRIQEIADGL 129 >2X8T-A nrPDB Length = 471 Score = 31.5 bits (70), Expect = 0.94, Method: Composition-based stats. Identities = 8/43 (18%), Positives = 15/43 (34%) Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSED 248 +HP + F +L V +GG ++ + F Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLP 207 >2P3V-A nrPDB Length = 256 Score = 29.9 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 12/77 (15%), Positives = 28/77 (36%), Gaps = 6/77 (7%) Query: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209 + L+ +G +L+ K K+++ D A + + + + Sbjct: 8 IKLLRKVGH------LLMIHWGRVDNVEKKTGFKDIVTEIDREAQRMIVDEIRKFFPDEN 61 Query: 210 LTALKYSFQTHDRLCFV 226 + A + F+ DRL + Sbjct: 62 IMAEEGIFEKGDRLWII 78 >6EF6-A nrPDB Length = 354 Score = 29.9 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 16/28 (57%), Gaps = 3/28 (10%) Query: 269 NVVYRDLKLENLMLDKD---GHIKITDF 293 +++ DL+L NL++D I + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >1XOC-A nrPDB Length = 520 Score = 29.5 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 16/83 (19%), Positives = 33/83 (39%), Gaps = 8/83 (9%) Query: 87 TFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKH--- 143 T+ V ++ + + + ++K+ + E+ F+ N ++ + PKH Sbjct: 106 TYSVPLSKDYKGERGSTYEMLKSVEKKGDYEVLFKLKYKDGNFYNNALDSTAILPKHILG 165 Query: 144 -----RVTMNEFEYLKLLGKGTF 161 + NEF K +G G F Sbjct: 166 NVPIADLEENEFNRKKPIGSGPF 188 >1IU8-A nrPDB Length = 206 Score = 29.5 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 7/34 (20%), Positives = 13/34 (38%) Query: 341 EMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGP 374 ++ G PF D +++ R P +G Sbjct: 3 ILLTGFEPFGGDDKNPTMDIVEALSERIPEVVGE 36 >5GW4-d nrPDB Length = 528 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 32/90 (35%) Query: 200 RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259 R+L HP + A + + ++E + L R S + ++ S Sbjct: 109 RLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSS 168 Query: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIK 289 L L + + D +N+ L+ +K Sbjct: 169 FLAPLAVDSVLKISDENSKNVDLNDIRLVK 198 >6B3J-R nrPDB Length = 491 Score = 29.1 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 8/48 (16%), Positives = 21/48 (43%), Gaps = 1/48 (2%) Query: 235 LFFHLSRERVFSED-RARFYGAEIVSALDYLHSEKNVVYRDLKLENLM 281 LF ++ ++ A + I+ +LH +N ++ +L ++ Sbjct: 151 LFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFIL 198 >5VEW-A nrPDB Length = 455 Score = 29.1 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 8/48 (16%), Positives = 21/48 (43%), Gaps = 1/48 (2%) Query: 235 LFFHLSRERVFSED-RARFYGAEIVSALDYLHSEKNVVYRDLKLENLM 281 LF ++ ++ A + I+ +LH +N ++ +L ++ Sbjct: 16 LFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFIL 63 >5NX2-A nrPDB Length = 422 Score = 29.1 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 8/48 (16%), Positives = 21/48 (43%), Gaps = 1/48 (2%) Query: 235 LFFHLSRERVFSED-RARFYGAEIVSALDYLHSEKNVVYRDLKLENLM 281 LF ++ ++ A + I+ +LH +N ++ +L ++ Sbjct: 123 LFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFIL 170 >5JY7-I nrPDB Length = 441 Score = 29.1 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 19/42 (45%), Gaps = 5/42 (11%) Query: 196 LTENRVLQNSRHPFLTALKYSFQTHDR-----LCFVMEYANG 232 + NRVL + +P + L SF+T L V E+A Sbjct: 158 IELNRVLARAGNPHVARLLGSFETEWEGEPYALGMVTEFAAN 199 >4GN1-A nrPDB Length = 255 Score = 29.1 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 11/25 (44%), Positives = 16/25 (64%), Gaps = 2/25 (8%) Query: 11 WLHKRGEYIKTWRPRYFLLKNDGTF 35 WL G+ K+W+ RYFLL+ G + Sbjct: 139 WLKDDGK--KSWKKRYFLLRASGIY 161 >5L2E-A nrPDB Length = 688 Score = 29.1 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 16/67 (23%), Positives = 25/67 (37%), Gaps = 2/67 (2%) Query: 28 LLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERT 87 L+ D +I E DVD +E L S+ + +++ P P RC + I T Sbjct: 230 LVAFDCHWIIINEEINDVDVQE--LVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISST 287 Query: 88 FHVETPE 94 Sbjct: 288 LCDPKDP 294 >5VAI-R nrPDB Length = 461 Score = 29.1 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 6/32 (18%), Positives = 15/32 (46%) Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLM 281 A + I+ +LH +N ++ +L ++ Sbjct: 197 ALVIASAILLGFRHLHCTRNYIHLNLFASFIL 228 >4EJ3-A nrPDB Length = 514 Score = 28.8 bits (63), Expect = 4.9, Method: Composition-based stats. Identities = 21/121 (17%), Positives = 45/121 (37%), Gaps = 6/121 (4%) Query: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60 + D+ + W + TW R L ++G + + V+ EA + VAQ Sbjct: 234 LGDLEGARTKWPLTGRTRVYTWPARGVRLLDEGDGVRFMGYGPGVEPLEATHRDPMVAQR 293 Query: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120 + N ++R + + R F P + + ++ + + E+E ++ Sbjct: 294 L-----DAKGNLLVLRLSEERS-FWRDFSAMLPRQGGKVAATLEHAENLQGELEDEGLEG 347 Query: 121 R 121 R Sbjct: 348 R 348 >5KBP-A nrPDB Length = 899 Score = 28.8 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 36/78 (46%), Gaps = 4/78 (5%) Query: 346 RLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405 RLPFY E L+ + + + + P K++ S ++K+D R G K+ + Sbjct: 428 RLPFYTGKPEDLYHELKQKATPDYQVIDPTGKAVASRIVKED--VRFGYDLP--KDAFRQ 483 Query: 406 RFFAGIVWQHVYEKKLSP 423 + A + + K+++P Sbjct: 484 PYMAKYLTVELSVKEMAP 501 >2GN9-A nrPDB Length = 344 Score = 28.4 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 21/92 (22%), Positives = 40/92 (43%), Gaps = 10/92 (10%) Query: 137 SLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 196 S++ P H+ ++ L G G+FGK + K T A KI+ + ++DE+ Sbjct: 9 SMSMPNHQNMLDNQTILITGGTGSFGKCFVRKVLDTTN--AKKII----VYSRDELKQ-- 60 Query: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVME 228 +E + P + + +RL + +E Sbjct: 61 SEMAM--EFNDPRMRFFIGDVRDLERLNYALE 90 >3DXK-D nrPDB Length = 300 Score = 28.4 bits (62), Expect = 8.1, Method: Composition-based stats. Identities = 5/33 (15%), Positives = 16/33 (48%) Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF 293 ++ +H+ ++ ++ +K + K +DF Sbjct: 241 INLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDF 273 >3L4B-C nrPDB Length = 218 Score = 28.0 bits (61), Expect = 8.4, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 20/44 (45%), Gaps = 1/44 (2%) Query: 161 FGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204 +G VI+ K++ +A K LK +I L + V +N Sbjct: 24 YGVVIINKDRELCEEFA-KKLKATIIHGDGSHKEILRDAEVSKN 66 >1T1M-C nrPDB Length = 185 Score = 28.0 bits (61), Expect = 9.6, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 26/77 (33%), Gaps = 16/77 (20%) Query: 164 VILVKEKATGRYYAM--------KILK---KEVIVAKDEVAHTLTENRVLQNSRHPFLTA 212 V KE A+ K +K KE ++ +D+ E Q F+ Sbjct: 114 VKKAKEIVEEGKIAIRNIRREILKKIKEDQKEGLIPEDDAKRLENEI---QKLTDEFIEK 170 Query: 213 LKYSFQTHDRLCFVMEY 229 L F+ +ME+ Sbjct: 171 LDEVFEIKKEE--IMEF 185 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.145 0.435 Lambda K H 0.267 0.0445 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,052,189 Number of Sequences: 36641 Number of extensions: 921077 Number of successful extensions: 6734 Number of sequences better than 10.0: 538 Number of HSP's better than 10.0 without gapping: 909 Number of HSP's successfully gapped in prelim test: 112 Number of HSP's that attempted gapping in prelim test: 2353 Number of HSP's gapped (non-prelim): 1151 length of query: 480 length of database: 10,336,785 effective HSP length: 101 effective length of query: 379 effective length of database: 6,636,044 effective search space: 2515060676 effective search space used: 2515060676 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 61 (28.0 bits)