BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P31324 (416 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4X6Q-B nrPDB 858 0.0 1CX4-A nrPDB 625 e-179 3J4Q-B nrPDB 559 e-160 2QVS-B nrPDB 492 e-139 4DIN-B nrPDB 249 1e-66 6BYS-B nrPDB 235 3e-62 2QCS-B nrPDB 230 7e-61 5KBF-A nrPDB 197 8e-51 5J3U-A nrPDB 174 6e-44 4Z07-A nrPDB 125 4e-29 5FET-A nrPDB 122 4e-28 3SHR-A nrPDB 121 5e-28 5DYK-A nrPDB 117 8e-27 6FTF-B nrPDB 105 3e-23 6BQ8-A nrPDB 71 1e-12 5H78-A nrPDB 68 8e-12 4QX5-A nrPDB 66 3e-11 5JAX-A nrPDB 66 4e-11 5H77-A nrPDB 65 6e-11 5XBY-A nrPDB 63 3e-10 5V4S-A nrPDB 51 8e-07 6CJQ-A nrPDB 49 5e-06 4MGY-E nrPDB 46 3e-05 1O7F-A nrPDB 45 5e-05 4EV0-A nrPDB 45 6e-05 4F7Z-A nrPDB 45 7e-05 4AVC-A nrPDB 44 1e-04 3DKW-A nrPDB 42 4e-04 4CHV-A nrPDB 42 4e-04 5JON-A nrPDB 41 0.001 3I59-A nrPDB 39 0.003 5W5B-A nrPDB 39 0.004 4ORF-A nrPDB 39 0.004 5U6P-A nrPDB 39 0.004 4CYD-A nrPDB 37 0.022 2GAU-A nrPDB 36 0.039 3H3Z-A nrPDB 33 0.24 4I0B-A nrPDB 32 0.56 3KCC-A nrPDB 32 0.63 5H3O-A nrPDB 30 2.0 5I62-A nrPDB 29 3.1 1DK5-A nrPDB 29 3.9 >4X6Q-B nrPDB Length = 416 Score = 858 bits (2218), Expect = 0.0, Method: Compositional matrix adjust. Identities = 415/416 (99%), Positives = 416/416 (100%) Query: 1 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGD 60 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGD Sbjct: 1 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGD 60 Query: 61 AGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNP 120 AGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNP Sbjct: 61 AGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNP 120 Query: 121 DEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVI 180 DEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVI Sbjct: 121 DEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVI 180 Query: 181 DQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPG 240 DQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTP+AATITATSPG Sbjct: 181 DQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPKAATITATSPG 240 Query: 241 ALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQ 300 ALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQ Sbjct: 241 ALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQ 300 Query: 301 IIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRA 360 IIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRA Sbjct: 301 IIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRA 360 Query: 361 ASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA 416 ASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA Sbjct: 361 ASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA 416 >1CX4-A nrPDB Length = 305 Score = 625 bits (1611), Expect = e-179, Method: Compositional matrix adjust. Identities = 300/305 (98%), Positives = 303/305 (99%) Query: 112 SVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEK 171 SVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEK Sbjct: 1 SVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEK 60 Query: 172 LVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRA 231 LVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRA Sbjct: 61 LVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRA 120 Query: 232 ATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIG 291 ATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIG Sbjct: 121 ATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIG 180 Query: 292 TKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGEL 351 TKVYNDGEQIIAQGD ADSFFIVESGEV+ITMKRKGKS++EENGAVEIARC RGQYFGEL Sbjct: 181 TKVYNDGEQIIAQGDSADSFFIVESGEVRITMKRKGKSDIEENGAVEIARCLRGQYFGEL 240 Query: 352 ALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDI 411 ALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDI Sbjct: 241 ALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDI 300 Query: 412 VEPTA 416 VEPTA Sbjct: 301 VEPTA 305 >3J4Q-B nrPDB Length = 402 Score = 559 bits (1441), Expect = e-160, Method: Compositional matrix adjust. Identities = 276/415 (66%), Positives = 329/415 (79%), Gaps = 21/415 (5%) Query: 3 IEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAG 62 I+IPAGLTELLQG+TVEVLR QP DL++FA+++FTRL+ E R+ + F T+ Sbjct: 4 IQIPAGLTELLQGYTVEVLRQQPPDLVDFAVEYFTRLR-EARRQESDTFIVSPTTFHTQE 62 Query: 63 AAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDE 122 ++A I E+GE + +E PV ++FTRR SVCAE +NPDE Sbjct: 63 SSAVPVI---------------EEDGESDSDSEDADLEVPVPSKFTRRVSVCAETFNPDE 107 Query: 123 EEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQ 182 EE+D + R++HPKTD+QR RLQEACKDILLFKNLD EQ+SQVLDAMFEK+VK EHVIDQ Sbjct: 108 EEEDNDPRVVHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFEKIVKTDEHVIDQ 167 Query: 183 GDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGAL 242 GDDGDNFYVI+RGT+DI V D R VG YDNRGSFGELALMYNTPRAATI ATS G+L Sbjct: 168 GDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIIATSEGSL 227 Query: 243 WGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQII 302 WGLDRVTFRRIIVKNNAKKRKM+ESFIES+P KSLE+SER+K+VDVIG K+Y DGE+II Sbjct: 228 WGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGERII 287 Query: 303 AQGDLADSFFIVESGEVKITMKRKGKSEVEENGA---VEIARCFRGQYFGELALVTNKPR 359 AQG+ ADSF+I+ESGEV I ++ K KS +NG VEIA C +GQYFGELALVTNKPR Sbjct: 288 AQGEKADSFYIIESGEVSILIRSKTKS--NKNGGNQEVEIAHCHKGQYFGELALVTNKPR 345 Query: 360 AASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEP 414 AASA+A+G VKCL MDVQAFERLLGPCM+IMKRNI+ YEEQLV +FG+N+D+++P Sbjct: 346 AASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSNLDLMDP 400 >2QVS-B nrPDB Length = 310 Score = 492 bits (1267), Expect = e-139, Method: Compositional matrix adjust. Identities = 234/310 (75%), Positives = 269/310 (86%), Gaps = 5/310 (1%) Query: 108 TRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDA 167 TRR SVCAE +NPDEEE+D + R++HPKTD+QR RLQEACKDILLFKNLD EQ+SQVLDA Sbjct: 1 TRRVSVCAETFNPDEEEEDNDPRVVHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDA 60 Query: 168 MFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYN 227 MFEK+VK EHVIDQGDDGDNFYVI+RGT+DI V D R VG YDNRGSFGELALMYN Sbjct: 61 MFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYN 120 Query: 228 TPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVV 287 TPRAATI ATS G+LWGLDRVTFRRIIVKNNAKKRKM+ESFIES+P KSLE+SER+K+V Sbjct: 121 TPRAATIIATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIV 180 Query: 288 DVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGA---VEIARCFR 344 DVIG K+Y DGE+IIAQG+ ADSF+I+ESGEV I ++ K KS +NG VEIA C + Sbjct: 181 DVIGEKIYKDGERIIAQGEKADSFYIIESGEVSILIRSKTKS--NKNGGNQEVEIAHCHK 238 Query: 345 GQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVAL 404 GQYFGELALVTNKPRAASA+ +G VKCL MDVQAFERLLGPCM+IMKRNI+ YEEQLV + Sbjct: 239 GQYFGELALVTNKPRAASAYGVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 298 Query: 405 FGTNMDIVEP 414 FG+N+D+++P Sbjct: 299 FGSNLDLMDP 308 >4DIN-B nrPDB Length = 381 Score = 249 bits (637), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 147/392 (37%), Positives = 210/392 (53%), Gaps = 46/392 (11%) Query: 8 GLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAGAAAGG 67 G+ ++L+ V + +P ++F +HF +L++E R+ AR Sbjct: 26 GIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILAR----------------- 68 Query: 68 GIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDA 127 +S+S++ +E N PV+ RR V AE Y E+DA Sbjct: 69 -------------QKSNSQSDSHDEEVSPTPPN-PVVKARRRRGGVSAEVYT----EEDA 110 Query: 128 ES--RIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDD 185 S R + PK L +A +LF +LD + S + DAMF GE VI QG++ Sbjct: 111 VSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNE 170 Query: 186 GDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGL 245 GDNFYV+D+G D+YV G V N GSFGELAL+Y TPRAAT+ A + LWG+ Sbjct: 171 GDNFYVVDQGEVDVYVN----GEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGI 226 Query: 246 DRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQG 305 DR ++RRI++ + +KRKMYE F+ + L+SLE ERL V D + + DGE+I+ QG Sbjct: 227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQG 286 Query: 306 DLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHA 365 + D F+I+ G + +R E VE+ R YFGE+AL+ N+PRAA+ A Sbjct: 287 EPGDDFYIITEGTASVLQRRSPNEEY-----VEVGRLGPSDYFGEIALLLNRPRAATVVA 341 Query: 366 IGTVKCLAMDVQAFERLLGPCMEIMKRNIATY 397 G +KC+ +D FER+LGPC EI+KRNI Y Sbjct: 342 RGPLKCVKLDRPRFERVLGPCSEILKRNIQRY 373 >6BYS-B nrPDB Length = 379 Score = 235 bits (599), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 132/298 (44%), Positives = 181/298 (60%), Gaps = 15/298 (5%) Query: 102 PVINRFTRRASVCAEAYNPDEEEDDAES--RIIHPKTDDQRNRLQEACKDILLFKNLDPE 159 PV+ RR ++ AE Y E+DA S R + PK L +A + +LF +LD Sbjct: 87 PVVKGRRRRGAISAEVYT----EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDN 142 Query: 160 QMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSF 219 + S + DAMF GE VI QGD+GDNFYVID+G D+YV + VG GSF Sbjct: 143 ERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEW-ATSVGE---GGSF 198 Query: 220 GELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLE 279 GELAL+Y TPRAAT+ A + LWG+DR ++RRI++ + +KRKMYE F+ + L+SL+ Sbjct: 199 GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLD 258 Query: 280 VSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEI 339 ERL V D + + DG++I+ QG+ D FFI+ G + +R SE EE VE+ Sbjct: 259 KWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRR---SENEE--FVEV 313 Query: 340 ARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATY 397 R YFGE+AL+ N+PRAA+ A G +KC+ +D FER+LGPC +I+KRNI Y Sbjct: 314 GRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQY 371 >2QCS-B nrPDB Length = 291 Score = 230 bits (587), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 127/289 (43%), Positives = 177/289 (61%), Gaps = 11/289 (3%) Query: 109 RRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAM 168 RR ++ AE Y EE+ + R + PK L +A + +LF +LD + S + DAM Sbjct: 5 RRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAM 62 Query: 169 FEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNT 228 F GE VI QGD+GDNFYVID+G D+YV + VG GSFGELAL+Y T Sbjct: 63 FPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEW-ATSVGE---GGSFGELALIYGT 118 Query: 229 PRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVD 288 PRAAT+ A + LWG+DR ++RRI++ + +KRKMYE F+ + L+SL+ ERL V D Sbjct: 119 PRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVAD 178 Query: 289 VIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYF 348 + + DG++I+ QG+ D FFI+ G + +R SE EE VE+ R YF Sbjct: 179 ALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRR---SENEE--FVEVGRLGPSDYF 233 Query: 349 GELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATY 397 GE+AL+ N+P+AA+ A G +KC+ +D FER+LGPC +I+KRNI Y Sbjct: 234 GEIALLMNRPKAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQY 282 >5KBF-A nrPDB Length = 301 Score = 197 bits (501), Expect = 8e-51, Method: Compositional matrix adjust. Identities = 113/297 (38%), Positives = 174/297 (58%), Gaps = 12/297 (4%) Query: 109 RRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAM 168 +R SV AEAY ++ D ++ K + ++ +++EA + LF +L+ ++ +++A Sbjct: 6 KRLSVSAEAYGDWNKKIDNFIPKVYKKDEKEKAKIREALNESFLFNHLNKKEFEIIVNAF 65 Query: 169 FEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VKCDGVGRCVGNYDNRGSFGELALMYN 227 F+K V++G ++I++GD GD YVID+G +IY K + + ++ FGELAL+YN Sbjct: 66 FDKNVEKGVNIINEGDYGDLLYVIDQGEVEIYKTKENNKKEVLTVLKSKDVFGELALLYN 125 Query: 228 TPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVV 287 + RAAT TA + LW LDR +F II AKKRKMYE + + LK ++ ER KV Sbjct: 126 SKRAATATALTKCHLWALDRESFTYIIKDMVAKKRKMYEDILSHVNILKDMDPYERCKVA 185 Query: 288 DVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQY 347 D + +K YNDGE II +G+ D+FFI+ G + K I +G Y Sbjct: 186 DCLKSKSYNDGEIIIKEGEEGDTFFILIDGNAVASKDNKV-----------IKTYTKGDY 234 Query: 348 FGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVAL 404 FGELAL+ NKPRAA+ A + + +D ++F+RLLGP +I+ RN+ Y++ L L Sbjct: 235 FGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLLGPIEDILHRNVENYKKVLNEL 291 >5J3U-A nrPDB Length = 261 Score = 174 bits (441), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 95/266 (35%), Positives = 151/266 (56%), Gaps = 5/266 (1%) Query: 132 IHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYV 191 ++ K + Q+ +L+ + LF +LD + ++ V+ AM EK ++ +I +GDDG+ Y+ Sbjct: 1 VYEKDEGQKEQLERILRQSFLFNSLDEKDLNTVILAMQEKKIEASTCLIREGDDGECLYI 60 Query: 192 IDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFR 251 + G + DG R V +FGELAL+YN PRAAT+T+ S LW L R TF Sbjct: 61 VQSGELNCSKLIDGEERVVKVVGPGDAFGELALLYNAPRAATVTSVSACDLWELGRDTFN 120 Query: 252 RIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSF 311 I+ K+R MY+SF++S+ L ++ ER KV D + T+++ DG I+ QG+L D F Sbjct: 121 AIVKDAATKRRSMYDSFLKSVHILDGMDAYERGKVADALRTEMFTDGAYIVRQGELGDVF 180 Query: 312 FIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKC 371 +IVE G T KS +E+ + G YFGELAL+ +PRAA+ A G K Sbjct: 181 YIVEEGSAVAT-----KSFGPGQPPIEVKKYQAGDYFGELALINEEPRAANVIAHGICKV 235 Query: 372 LAMDVQAFERLLGPCMEIMKRNIATY 397 ++ ++F+RL+G +++ + + Y Sbjct: 236 ACLERKSFKRLMGSVQDLLSKKASEY 261 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 44/160 (27%), Positives = 79/160 (49%), Gaps = 11/160 (6%) Query: 99 FNAPVINRFTRRASVCA-EAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLD 157 +NAP R A+V + A + E D + I+ +R+ K + + +D Sbjct: 95 YNAP------RAATVTSVSACDLWELGRDTFNAIVKDAATKRRSMYDSFLKSVHILDGMD 148 Query: 158 PEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRC---VGNYD 214 + +V DA+ ++ +G +++ QG+ GD FY+++ G+ + K G G+ V Y Sbjct: 149 AYERGKVADALRTEMFTDGAYIVRQGELGDVFYIVEEGS-AVATKSFGPGQPPIEVKKYQ 207 Query: 215 NRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRII 254 FGELAL+ PRAA + A + L+R +F+R++ Sbjct: 208 AGDYFGELALINEEPRAANVIAHGICKVACLERKSFKRLM 247 >4Z07-A nrPDB Length = 262 Score = 125 bits (314), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 79/252 (31%), Positives = 126/252 (50%), Gaps = 9/252 (3%) Query: 133 HPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVI 192 +PK+ ++ ++EA D KNL+ Q+ +++D M+ + +I +GD G YV+ Sbjct: 10 YPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVM 69 Query: 193 DRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRR 252 + G + V +GV C FGELA++YN R AT+ LW +DR F+ Sbjct: 70 EDGKVE--VTKEGVKLCTMGPGK--VFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQT 125 Query: 253 IIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFF 312 I+++ K Y F++S+P +SL K+ DV+ Y +GE II QG D+FF Sbjct: 126 IMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFF 185 Query: 313 IVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCL 372 I+ G V +T + + V + +G +FGE AL R A+ A V CL Sbjct: 186 IISKGTVNVT-----REDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCL 240 Query: 373 AMDVQAFERLLG 384 +D +F+ L+G Sbjct: 241 VIDRDSFKHLIG 252 >5FET-A nrPDB Length = 847 Score = 122 bits (305), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 78/263 (29%), Positives = 135/263 (51%), Gaps = 15/263 (5%) Query: 143 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVK 202 ++ + K+ L+ L+ ++ + + M + K G+ VI QG+ G F++I+ G FD+YV Sbjct: 43 IKASLKNNLVCSTLNDNEILTLSNYMQFFVFKGGDLVIKQGEKGSYFFIINSGKFDVYVN 102 Query: 203 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKR 262 + V + SFGE AL++NT R+ATI A + G LWG+ R TFR + + + + Sbjct: 103 ----DKKVKSMGKGSSFGEAALIHNTQRSATIMAETDGTLWGVQRSTFRATLKQLSNRNF 158 Query: 263 KMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKIT 322 SFI+S+ L +++ + + +++ GE I+ QGD D FI++ G+ + Sbjct: 159 NENRSFIDSVSVFDMLTEAQKNMITNACVIQMFKPGETIVKQGDYGDVLFILKEGKATVF 218 Query: 323 MKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERL 382 + K EI +G YFGE AL+ ++PR+A+ A C ++ + + Sbjct: 219 INDK-----------EIRVLNKGSYFGERALLYDEPRSATIIAKEPTACASICRKLLNIV 267 Query: 383 LGPCMEIMKRNIATYEEQLVALF 405 LG ++ RNI T Q +F Sbjct: 268 LGNLQVVLFRNIMTEALQQSEIF 290 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 34/116 (29%), Positives = 61/116 (52%), Gaps = 5/116 (4%) Query: 140 RNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDI 199 N + K + +F+ L +Q + +++A +EG+++I +G+ G FY+I G ++ Sbjct: 400 HNNKKSIIKKMYIFRYLSEQQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEV 459 Query: 200 YVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGA-LWGLDRVTFRRII 254 K R +G D FGE AL+Y+ PR A+I + + W +D+ F +II Sbjct: 460 -TKNGKRLRTLGKND---YFGERALLYDEPRTASIISKATSVECWFVDKSVFLQII 511 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 55/266 (20%), Positives = 118/266 (44%), Gaps = 30/266 (11%) Query: 140 RNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGD-DGDNFYVIDRGTFD 198 RN + EA + +F+ EQ++ + D + H++ + + ++ G + Sbjct: 277 RNIMTEALQQSEIFRQFSAEQLNDLADTAIVRDYPANYHILHKDKVKSVKYLIVLEGKVE 336 Query: 199 IYVKCDGVG-----RCVGN---YDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTF 250 +++ + +G + G+ + + F + + A IT + G + + Sbjct: 337 LFLDDESIGILTRGKSFGDQYVLNQKQKFRHTVKSLDVCKIALITESCLADCLGDNNIDA 396 Query: 251 RRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADS 310 + +N KK S I+ + + L + +++ T Y +G+ II +G++ Sbjct: 397 S---IDHNNKK-----SIIKKMYIFRYLSEQQCNLLIEAFRTTRYEEGDYIIQEGEVGSR 448 Query: 311 FFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGT-V 369 F+I+++GEV++T K + +N YFGE AL+ ++PR AS + T V Sbjct: 449 FYIIKNGEVEVTKNGKRLRTLGKN-----------DYFGERALLYDEPRTASIISKATSV 497 Query: 370 KCLAMDVQAFERLL-GPCMEIMKRNI 394 +C +D F +++ GP + ++ I Sbjct: 498 ECWFVDKSVFLQIIQGPMLTHLEERI 523 >3SHR-A nrPDB Length = 299 Score = 121 bits (304), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 78/250 (31%), Positives = 126/250 (50%), Gaps = 9/250 (3%) Query: 135 KTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDR 194 K++ ++ ++EA D KNL+ Q+ +++D M+ + +I +GD G YV++ Sbjct: 29 KSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMED 88 Query: 195 GTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRII 254 G + V +GV C FGELA++YN R AT+ LW +DR F+ I+ Sbjct: 89 GKVE--VTKEGVKLCTMGPGK--VFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIM 144 Query: 255 VKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIV 314 ++ K Y F++S+P +SL K+ DV+ Y +GE II QG D+FFI+ Sbjct: 145 MRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFII 204 Query: 315 ESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAM 374 G+V +T + + V + +G +FGE AL R A+ A V CL + Sbjct: 205 SKGKVNVT-----REDSPNEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVI 259 Query: 375 DVQAFERLLG 384 D +F+ L+G Sbjct: 260 DRDSFKHLIG 269 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/134 (27%), Positives = 61/134 (45%), Gaps = 10/134 (7%) Query: 139 QRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFD 198 + E K + F++L E +S++ D + E + GE++I QG GD F++I +G + Sbjct: 151 KHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVN 210 Query: 199 IYVKCDGVG------RCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRR 252 + + D R +G D FGE AL R A + A +DR +F+ Sbjct: 211 V-TREDSPNEDPVFLRTLGKGD---WFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKH 266 Query: 253 IIVKNNAKKRKMYE 266 +I + K YE Sbjct: 267 LIGGLDDVSNKAYE 280 >5DYK-A nrPDB Length = 853 Score = 117 bits (293), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 80/282 (28%), Positives = 139/282 (49%), Gaps = 18/282 (6%) Query: 124 EDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQG 183 ED E R K + + ++ + K+ L+ L+ ++ + + M + K G VI QG Sbjct: 33 EDHLELR---EKLSEDIDMIKTSLKNNLVCSTLNDNEILTLSNYMQFFVFKSGNLVIKQG 89 Query: 184 DDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALW 243 + G F++I+ G FD+YV + V SFGE AL++NT R+ATI A + G LW Sbjct: 90 EKGSYFFIINSGKFDVYVN----DKKVKTMGKGSSFGEAALIHNTQRSATIIAETDGTLW 145 Query: 244 GLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIA 303 G+ R TFR + + + + +FI+S+ L +++ + + + + GE I+ Sbjct: 146 GVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDMLTEAQKNMITNACVIQNFKSGETIVK 205 Query: 304 QGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASA 363 QGD D +I++ G+ + + + EI +G YFGE AL+ ++PR+A+ Sbjct: 206 QGDYGDVLYILKEGKATVYINDE-----------EIRVLEKGSYFGERALLYDEPRSATI 254 Query: 364 HAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALF 405 A C ++ + +LG ++ RNI T Q +F Sbjct: 255 IAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIF 296 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 52/169 (30%), Positives = 82/169 (48%), Gaps = 29/169 (17%) Query: 141 NRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY 200 N + K + +F+ L +Q + +++A +EG+++I +G+ G FY+I G +I Sbjct: 407 NNKKSIIKKMYIFRYLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEI- 465 Query: 201 VKCDGVGRCVGNYDNRGSFGELALMYNTPRAAT-ITATSPGALWGLDRVTFRRIIVKNNA 259 VK R +G D FGE AL+Y+ PR A+ I+ + W +D+ F +II Sbjct: 466 VKNKKRLRTLGKND---YFGERALLYDEPRTASVISKVNNVECWFVDKSVFLQII----- 517 Query: 260 KKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYND---GEQIIAQG 305 P L LE ER+K+ D TKV D E+II +G Sbjct: 518 -----------QGPMLAHLE--ERIKMQD---TKVEMDELETERIIGRG 550 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 58/263 (22%), Positives = 115/263 (43%), Gaps = 24/263 (9%) Query: 140 RNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVID-RGTFD 198 RN + EA + +FK +Q++ + D + +++ + Y+I G + Sbjct: 283 RNIMTEALQQSEIFKQFSGDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVE 342 Query: 199 IYVKCDGVGRCVGNYDNRG-SFG-ELALMYNTPRAATITATSPGALWGLDRVTFRRIIVK 256 +++ +G +RG SFG + L P TI + + + + Sbjct: 343 LFLDDTSIGIL-----SRGMSFGDQYVLNQKQPFKHTIKSLEVCKIALITETCLADCLGN 397 Query: 257 NNAKKRKMY---ESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFI 313 NN Y +S I+ + + L + +++ T Y +G+ II +G++ F+I Sbjct: 398 NNIDASIDYNNKKSIIKKMYIFRYLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYI 457 Query: 314 VESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASA-HAIGTVKCL 372 +++GEV+I +K + +N YFGE AL+ ++PR AS + V+C Sbjct: 458 IKNGEVEIVKNKKRLRTLGKN-----------DYFGERALLYDEPRTASVISKVNNVECW 506 Query: 373 AMDVQAFERLL-GPCMEIMKRNI 394 +D F +++ GP + ++ I Sbjct: 507 FVDKSVFLQIIQGPMLAHLEERI 529 >6FTF-B nrPDB Length = 304 Score = 105 bits (263), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 77/293 (26%), Positives = 140/293 (47%), Gaps = 28/293 (9%) Query: 109 RRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAM 168 RR +V +E +P E+ K++D+ N + + +LF L+ + + V AM Sbjct: 4 RRRTVRSEGIDP--EKAKLYQAPYFEKSEDEMNLITKLLTHNVLFSFLNTKDIKVVAGAM 61 Query: 169 FEKLVKEGEHVIDQGDDGDN-FYVIDRGTFDI-------YVKCDGVGRCVGNYDNRGSFG 220 K + +++ G N Y+I G DI Y+K +G + G Sbjct: 62 QRATFKHDDCIMEAGQTTCNKLYIIQSGHADIIKEGQKVYLKTEGT-----------AVG 110 Query: 221 ELALMYNTPRAATITATSPGAL-WGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLE 279 EL LMY+TP AT+ + + W LDR T+R +++ ++R+ Y F+ ++PFL L+ Sbjct: 111 ELELMYDTPVVATVKVCTDELIAWVLDRDTYRNLVMGTAIRRRETYIQFLANVPFLGGLD 170 Query: 280 VSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEI 339 E+L++ D + ++ ++ GE II G+ + +I+ G V++ + R E ++ Sbjct: 171 SYEKLQLADALSSEEFSPGEYIIHYGEEGEWLYIIMEGTVEV-IGRDADGE-----PTKV 224 Query: 340 ARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKR 392 +G + GEL + N A A V ++ + FE LGP ++++KR Sbjct: 225 CEFTQGDHIGELEFLNNHRTVADVVATTHVITAKLNRRHFEMCLGPVIDVLKR 277 >6BQ8-A nrPDB Length = 152 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 40/130 (30%), Positives = 73/130 (56%), Gaps = 6/130 (4%) Query: 263 KMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKIT 322 + Y +F+ S+ LK+L + K++D + + Y+ G+ II +G+ +FFI+ G+VK+T Sbjct: 9 EQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVT 68 Query: 323 MKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHA-IGTVKCLAMDVQAFER 381 +G + + I +G+YFGE AL+++ R+A+ A V CL +D + F + Sbjct: 69 QSTEGHDQPQ-----LIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQ 123 Query: 382 LLGPCMEIMK 391 +G E+ K Sbjct: 124 TVGTFEELQK 133 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 26/110 (23%), Positives = 58/110 (52%), Gaps = 3/110 (2%) Query: 148 KDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVG 207 + + L KNL +++++++D + + +G+++I +G++G F+++ +G + +G Sbjct: 16 RSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHD 75 Query: 208 --RCVGNYDNRGSFGELALMYNTPRAATITATSPG-ALWGLDRVTFRRII 254 + + FGE AL+ + R+A I A A +DR TF + + Sbjct: 76 QPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTV 125 >5H78-A nrPDB Length = 197 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 29/58 (50%), Positives = 41/58 (70%) Query: 3 IEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGD 60 ++IP GLTELLQG+TVEVLR QP DL+EFA+++FTRL+ E + + + + D Sbjct: 4 MQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLRSERVNERVKQLAEKAKEATD 61 >4QX5-A nrPDB Length = 153 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 41/124 (33%), Positives = 61/124 (49%), Gaps = 5/124 (4%) Query: 261 KRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVK 320 K Y F++S+P +SL K+ DV+ Y +GE II QG D+FFI+ G V Sbjct: 7 KHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVN 66 Query: 321 ITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFE 380 +T + + V + +G +FGE AL R A+ A V CL +D +F+ Sbjct: 67 VT-----REDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFK 121 Query: 381 RLLG 384 L+G Sbjct: 122 HLIG 125 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 38/134 (28%), Positives = 62/134 (46%), Gaps = 10/134 (7%) Query: 139 QRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFD 198 + E K + F++L E +S++ D + E + GE++I QG GD F++I +GT + Sbjct: 7 KHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVN 66 Query: 199 IYVKCDGVG------RCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRR 252 + + D R +G D FGE AL R A + A +DR +F+ Sbjct: 67 V-TREDSPSEDPVFLRTLGKGD---WFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKH 122 Query: 253 IIVKNNAKKRKMYE 266 +I + K YE Sbjct: 123 LIGGLDDVSNKAYE 136 >5JAX-A nrPDB Length = 135 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 41/124 (33%), Positives = 61/124 (49%), Gaps = 5/124 (4%) Query: 261 KRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVK 320 K Y F++S+P +SL K+ DV+ Y +GE II QG D+FFI+ G V Sbjct: 7 KHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVN 66 Query: 321 ITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFE 380 +T + + V + +G +FGE AL R A+ A V CL +D +F+ Sbjct: 67 VT-----REDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFK 121 Query: 381 RLLG 384 L+G Sbjct: 122 HLIG 125 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 10/122 (8%) Query: 139 QRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFD 198 + E K + F++L E +S++ D + E + GE++I QG GD F++I +GT + Sbjct: 7 KHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVN 66 Query: 199 IYVKCDGVG------RCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRR 252 + + D R +G D FGE AL R A + A +DR +F+ Sbjct: 67 V-TREDSPSEDPVFLRTLGKGD---WFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKH 122 Query: 253 II 254 +I Sbjct: 123 LI 124 >5H77-A nrPDB Length = 90 Score = 65.1 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 28/39 (71%), Positives = 36/39 (92%) Query: 4 EIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQE 42 +IP GLTELLQG+TVEVLR QP DL+EFA+++FTRL+Q+ Sbjct: 5 QIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLRQQ 43 >5XBY-A nrPDB Length = 97 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 28/48 (58%), Positives = 38/48 (79%) Query: 4 EIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARF 51 +IP GLTELLQG+TVEVLR QP DL+EFA+++FTRL++ ++ F Sbjct: 5 QIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARNKEQQNAF 52 >5V4S-A nrPDB Length = 465 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 60/123 (48%), Gaps = 9/123 (7%) Query: 261 KRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVK 320 K +++ +E +PFLK + + +V + ++ +G+ I +G+ D +I+ G V Sbjct: 332 KIQLHRDLLEKVPFLKGADPALVTSLVFSMKPMIFLEGDTIFRRGEKGDDLYILSEGSVD 391 Query: 321 ITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFE 380 I ++ + + GQ+FGELALV + PR+A+ A T + + F+ Sbjct: 392 I---------LDSDEKTILLSLQEGQFFGELALVMDAPRSATVRATTTCEIYTLSKTDFD 442 Query: 381 RLL 383 +L Sbjct: 443 NVL 445 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 9/120 (7%) Query: 152 LFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVG 211 K DP ++ ++ +M + EG+ + +G+ GD+ Y++ G+ DI D + + Sbjct: 345 FLKGADPALVTSLVFSMKPMIFLEGDTIFRRGEKGDDLYILSEGSVDI---LDSDEKTIL 401 Query: 212 NYDNRGS-FGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIE 270 G FGELAL+ + PR+AT+ AT+ ++ L + F N K+ + S IE Sbjct: 402 LSLQEGQFFGELALVMDAPRSATVRATTTCEIYTLSKTDF-----DNVLKRFSQFRSAIE 456 >6CJQ-A nrPDB Length = 456 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 37/132 (28%), Positives = 66/132 (50%), Gaps = 11/132 (8%) Query: 145 EACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 204 + + + LFK E + ++ + + GE++I G+ G + Y I+RG+ ++ + D Sbjct: 313 DVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGSVEV-LSAD 371 Query: 205 GVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRII---------V 255 R + + FGE+AL+ PR AT+ A + L+ LD+ TF RI+ + Sbjct: 372 EKTRYAILSEGQ-FFGEMALILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEIAAQI 430 Query: 256 KNNAKKRKMYES 267 + A +RK ES Sbjct: 431 QELAVRRKELES 442 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 9/96 (9%) Query: 294 VYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELAL 353 +Y GE II G++ + + G V++ + + A GQ+FGE+AL Sbjct: 340 IYGPGEYIIRAGEMGSDVYFINRGSVEV---------LSADEKTRYAILSEGQFFGEMAL 390 Query: 354 VTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEI 389 + PR A+ A +D + F+R+L EI Sbjct: 391 ILRAPRTATVRARAFCDLYRLDKETFDRILSRYPEI 426 >4MGY-E nrPDB Length = 694 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 70/138 (50%), Gaps = 14/138 (10%) Query: 126 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKEGE 177 DA R+I K QR + L+ ++L K L +++ VL +FE K G Sbjct: 8 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 65 Query: 178 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT 237 + +QG++G ++Y+I +G+ ++ + GV + D+ FG+LAL+ + PRAA+I Sbjct: 66 VLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD---FGQLALVNDAPRAASIVLR 122 Query: 238 SPGA-LWGLDRVTFRRII 254 +D+ F RI+ Sbjct: 123 EDNCHFLRVDKEDFNRIL 140 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 20/95 (21%) Query: 291 GTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGE 350 GT ++N GE+ S++I+ G V + + KG + G FG+ Sbjct: 64 GTVLFNQGEE-------GTSWYIILKGSVNVVIYGKGV----------VCTLHEGDDFGQ 106 Query: 351 LALVTNKPRAASAHAIGTVKC--LAMDVQAFERLL 383 LALV + PRAAS + C L +D + F R+L Sbjct: 107 LALVNDAPRAASI-VLREDNCHFLRVDKEDFNRIL 140 >1O7F-A nrPDB Length = 469 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 42/150 (28%), Positives = 74/150 (49%), Gaps = 14/150 (9%) Query: 126 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKEGE 177 DA R+I K QR + L+ ++L K L +++ VL +FE K G Sbjct: 313 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 370 Query: 178 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT 237 + +QG++G ++Y+I +G+ ++ + GV + D+ FG+LAL+ + PRAA+I Sbjct: 371 VLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD---FGKLALVNDAPRAASIVLR 427 Query: 238 SPGA-LWGLDRVTFRRIIVKNNAKKRKMYE 266 +D+ F RI+ A ++ E Sbjct: 428 EDNCHFLRVDKEDFNRILRDVEANTVRLKE 457 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 51/109 (46%), Gaps = 8/109 (7%) Query: 148 KDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYV-----K 202 K + F+ P + Q+ + + +++G + QGD G N+Y + G+ D+ V Sbjct: 45 KGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH 104 Query: 203 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFR 251 D V C +FGE +++ NTPR ATI L +++ F+ Sbjct: 105 QDAVTICTLGIGT--AFGE-SILDNTPRHATIVTRESSELLRIEQEDFK 150 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 20/95 (21%) Query: 291 GTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGE 350 GT ++N GE+ S++I+ G V + + KG + G FG+ Sbjct: 369 GTVLFNQGEE-------GTSWYIILKGSVNVVIYGKGV----------VCTLHEGDDFGK 411 Query: 351 LALVTNKPRAASAHAIGTVKC--LAMDVQAFERLL 383 LALV + PRAAS + C L +D + F R+L Sbjct: 412 LALVNDAPRAASI-VLREDNCHFLRVDKEDFNRIL 445 >4EV0-A nrPDB Length = 216 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 44/82 (53%), Gaps = 6/82 (7%) Query: 293 KVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELA 352 ++Y G+ I QGDL + ++V SG+V++ G E +A G+ FGE++ Sbjct: 25 RLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQE------RTLALLGPGELFGEMS 78 Query: 353 LVTNKPRAASAHAIGTVKCLAM 374 L+ R+ASA A+ + LA+ Sbjct: 79 LLDEGERSASAVAVEDTELLAL 100 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 1/104 (0%) Query: 152 LFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VKCDGVGRCV 210 LF L PE++ L +L +G+ + QGD G Y++ G ++ G R + Sbjct: 6 LFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQERTL 65 Query: 211 GNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRII 254 FGE++L+ R+A+ A L L R + +I Sbjct: 66 ALLGPGELFGEMSLLDEGERSASAVAVEDTELLALFREDYLALI 109 >4F7Z-A nrPDB Length = 999 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 13/118 (11%) Query: 126 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKEGE 177 DA R+I K QR + L+ ++L K L +++ VL +FE K G Sbjct: 313 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 370 Query: 178 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATIT 235 + +QG++G ++Y+I +G+ ++ + GV + D+ FG+LAL+ + PRAA+I Sbjct: 371 VLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD---FGKLALVNDAPRAASIV 425 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 8/111 (7%) Query: 148 KDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYV-----K 202 K + F+ P + Q+ + + +++G + QGD G N+Y + G+ D+ V Sbjct: 45 KGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSH 104 Query: 203 CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRI 253 D V C +FGE +++ NTPR ATI L +++ F+ + Sbjct: 105 QDAVTICTLGIGT--AFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 152 Score = 35.4 bits (80), Expect = 0.047, Method: Compositional matrix adjust. Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 17/72 (23%) Query: 291 GTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGE 350 GT ++N GE+ S++I+ G V + + KG + G FG+ Sbjct: 369 GTVLFNQGEE-------GTSWYIILKGSVNVVIYGKGV----------VCTLHEGDDFGK 411 Query: 351 LALVTNKPRAAS 362 LALV + PRAAS Sbjct: 412 LALVNDAPRAAS 423 >4AVC-A nrPDB Length = 333 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 23/69 (33%), Positives = 38/69 (55%), Gaps = 7/69 (10%) Query: 298 GEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNK 357 G+ ++ QG+ A SF ++ SG ++ S V ++G IAR G GE+AL+ + Sbjct: 44 GQVLLRQGEPAVSFLLISSGSAEV-------SHVGDDGVAIIARALPGMIVGEIALLRDS 96 Query: 358 PRAASAHAI 366 PR+A+ I Sbjct: 97 PRSATVTTI 105 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 50/105 (47%), Gaps = 8/105 (7%) Query: 176 GEHVIDQGDDGDNFYVIDRGTFDI-YVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATI 234 G+ ++ QG+ +F +I G+ ++ +V DGV + GE+AL+ ++PR+AT+ Sbjct: 44 GQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVA-IIARALPGMIVGEIALLRDSPRSATV 102 Query: 235 TATSPGALWGLDRVTFRRIIVKNNAKKRKM------YESFIESLP 273 T P W R F ++ +R + +F+ +P Sbjct: 103 TTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIP 147 >3DKW-A nrPDB Length = 227 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 2/117 (1%) Query: 144 QEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VK 202 Q+ + LF+ L P Q+ ++L + + +G +V QG+ FY + G IY + Sbjct: 8 QQLLQSHHLFEPLSPVQLQELLASSDLVNLDKGAYVFRQGEPAHAFYYLISGCVKIYRLT 67 Query: 203 CDGVGRCVGNYDNRGSFGELALMYNTPR-AATITATSPGALWGLDRVTFRRIIVKNN 258 +G + + + R +F E + +TP AT A P L+ + R + N Sbjct: 68 PEGQEKILEVTNERNTFAEAMMFMDTPNYVATAQAVVPSQLFRFSNKAYLRQLQDNT 124 >4CHV-A nrPDB Length = 361 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 31/122 (25%), Positives = 53/122 (43%), Gaps = 13/122 (10%) Query: 268 FIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKG 327 + ++P + L + +++V + + G I G+ D F V G V Sbjct: 229 LVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSV-------- 280 Query: 328 KSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCM 387 V VE+ G +FGE+AL++ +PR+A+ A TV L++ F+ L Sbjct: 281 --SVATPNPVELGP---GAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQMLCSSSP 335 Query: 388 EI 389 EI Sbjct: 336 EI 337 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 56/119 (47%), Gaps = 8/119 (6%) Query: 135 KTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDR 194 + D RN + + LF+ L P + +++ A+ + V G + G+ GD + + Sbjct: 220 RGDFVRN--WQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVE 277 Query: 195 GTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRI 253 G+ + + V G + FGE+AL+ PR+AT++A + +L L F+ + Sbjct: 278 GSVSVATP-NPVELGPGAF-----FGEMALISGEPRSATVSAATTVSLLSLHSADFQML 330 >5JON-A nrPDB Length = 517 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/134 (23%), Positives = 57/134 (42%), Gaps = 17/134 (12%) Query: 250 FRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLAD 309 R IV N +K + S+P + + + ++ + +V+ G+ II +G + Sbjct: 376 LREEIVNFNCRK------LVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGK 429 Query: 310 SFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTV 369 + ++ G V + K G E+ + G YFGE+ L+T R AS A Sbjct: 430 KMYFIQHGVVSVLTK--GNKEM---------KLSDGSYFGEICLLTRGRRTASVRADTYC 478 Query: 370 KCLAMDVQAFERLL 383 + ++ V F +L Sbjct: 479 RLYSLSVDNFNEVL 492 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/104 (25%), Positives = 49/104 (47%), Gaps = 6/104 (5%) Query: 152 LFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCV- 210 LF N DP ++ +L + ++ + G+++I +G G Y I G + K + + Sbjct: 394 LFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSD 453 Query: 211 GNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRII 254 G+Y FGE+ L+ R A++ A + L+ L F ++ Sbjct: 454 GSY-----FGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVL 492 >3I59-A nrPDB Length = 249 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 30/110 (27%), Positives = 52/110 (47%), Gaps = 12/110 (10%) Query: 280 VSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEI 339 ++++L+ VD + G + A+G+ D +I+ SG+VKI + + EN + Sbjct: 47 LTKQLQPVD------FPRGHTVFAEGEPGDRLYIIISGKVKIGRR---APDGRENLLTIM 97 Query: 340 ARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEI 389 FGEL++ PR +SA I V+ ++MD A + EI Sbjct: 98 GPS---DMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEI 144 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 24/104 (23%), Positives = 43/104 (41%), Gaps = 1/104 (0%) Query: 152 LFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKC-DGVGRCV 210 +F+ ++P ++ + + G V +G+ GD Y+I G I + DG + Sbjct: 35 IFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLL 94 Query: 211 GNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRII 254 FGEL++ PR ++ T + +DR R I Sbjct: 95 TIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWI 138 >5W5B-A nrPDB Length = 236 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/119 (21%), Positives = 53/119 (44%), Gaps = 13/119 (10%) Query: 286 VVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITM---KRKGKSEVEENGAVEIARC 342 + + + K + G + AD +IV G +++ + +R+ + G V+ Sbjct: 45 LAETLQVKEFAPGAVVFHADQTADGVWIVRHGLIELAVGSRRRRAVVNILHPGDVD---- 100 Query: 343 FRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 401 G++ L+ P + A+ CL +D QAFERLL I +R +++ +++ Sbjct: 101 ------GDIPLLLEMPMVYTGRALTQATCLFLDRQAFERLLATHPAIARRWLSSVAQRV 153 >4ORF-A nrPDB Length = 340 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 7/86 (8%) Query: 298 GEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNK 357 G+ +I QGD A +F ++ESG V++ S +G + G GE+AL+ + Sbjct: 48 GQVLIRQGDPALTFMLIESGRVQV-------SHAVADGPPIVLDIEPGLIIGEIALLRDA 100 Query: 358 PRAASAHAIGTVKCLAMDVQAFERLL 383 P+ A+ A V D AF+ +L Sbjct: 101 PKTATVVAAEPVIGWVGDRDAFDTIL 126 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 2/82 (2%) Query: 174 KEGEHVIDQGDDGDNFYVIDRGTFDI-YVKCDGVGRCVGNYDNRGSFGELALMYNTPRAA 232 + G+ +I QGD F +I+ G + + DG V + + GE+AL+ + P+ A Sbjct: 46 EPGQVLIRQGDPALTFMLIESGRVQVSHAVADG-PPIVLDIEPGLIIGEIALLRDAPKTA 104 Query: 233 TITATSPGALWGLDRVTFRRII 254 T+ A P W DR F I+ Sbjct: 105 TVVAAEPVIGWVGDRDAFDTIL 126 >5U6P-A nrPDB Length = 660 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/104 (25%), Positives = 48/104 (46%), Gaps = 6/104 (5%) Query: 152 LFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCV- 210 LF N DP ++ +L + ++ + G+++I +G G Y I G + K + Sbjct: 475 LFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTD 534 Query: 211 GNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRII 254 G+Y FGE+ L+ R A++ A + L+ L F ++ Sbjct: 535 GSY-----FGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVL 573 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 27/134 (20%), Positives = 56/134 (41%), Gaps = 17/134 (12%) Query: 250 FRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLAD 309 R IV N +K + ++P + + + ++ + +V+ G+ II +G + Sbjct: 457 LREEIVNFNCRK------LVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGK 510 Query: 310 SFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTV 369 + ++ G + K + ++ + G YFGE+ L+T R AS A Sbjct: 511 KMYFIQHGVAGVITKSSKEMKLTD-----------GSYFGEICLLTKGRRTASVRADTYC 559 Query: 370 KCLAMDVQAFERLL 383 + ++ V F +L Sbjct: 560 RLYSLSVDNFNEVL 573 >4CYD-A nrPDB Length = 225 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 1/92 (1%) Query: 143 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVK 202 +QE +F+ +DP ++ ++ M G + D+G+ GD Y+I G + Sbjct: 2 VQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARH 61 Query: 203 C-DGVGRCVGNYDNRGSFGELALMYNTPRAAT 233 DG + FGEL++ PR ++ Sbjct: 62 APDGRENLLTIMGPSDMFGELSIFDPGPRTSS 93 Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust. Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 6/81 (7%) Query: 295 YNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALV 354 + G I +G+ D +I+ SG+VK+ + + EN + FGEL++ Sbjct: 32 FPRGATIFDEGEPGDRLYIITSGKVKLA---RHAPDGRENLLTIMGPS---DMFGELSIF 85 Query: 355 TNKPRAASAHAIGTVKCLAMD 375 PR +SA + V M+ Sbjct: 86 DPGPRTSSAVCVTEVHAATMN 106 >2GAU-A nrPDB Length = 232 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 8/84 (9%) Query: 301 IIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFR-GQYFGELALVTNKPR 359 + ++GD+ ++ F + G++KI R+G G I+R + GQ+FG + Sbjct: 44 VFSEGDIPNNLFYLYEGKIKIL--REGVY-----GRFHISRIVKPGQFFGMRPYFAEETC 96 Query: 360 AASAHAIGTVKCLAMDVQAFERLL 383 +++A A+ K LA+ V+A E LL Sbjct: 97 SSTAIAVENSKVLAIPVEAIEALL 120 >3H3Z-A nrPDB Length = 235 Score = 33.1 bits (74), Expect = 0.24, Method: Compositional matrix adjust. Identities = 27/105 (25%), Positives = 45/105 (42%), Gaps = 8/105 (7%) Query: 293 KVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCF-RGQYFGEL 351 + Y+ GE + Q + A + +V G VK+ + G+ + F RG+ FGE Sbjct: 35 RSYDRGETLFLQEEKAQAIHVVIDGWVKLF-------RMTPTGSEAVVSVFTRGESFGEA 87 Query: 352 ALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIAT 396 + N P SA A+ + + + F L+ EI +AT Sbjct: 88 VALRNTPYPVSAEAVTPCEVMHIPSPVFVSLMRRDPEICISILAT 132 Score = 31.6 bits (70), Expect = 0.68, Method: Compositional matrix adjust. Identities = 21/93 (22%), Positives = 39/93 (41%), Gaps = 1/93 (1%) Query: 148 KDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVG 207 ++ LL ++L + + +L + GE + Q + +V+ G ++ Sbjct: 12 RNSLLIRSLPEQHVDALLSQAVWRSYDRGETLFLQEEKAQAIHVVIDGWVKLFRMTPTGS 71 Query: 208 RCVGNYDNRG-SFGELALMYNTPRAATITATSP 239 V + RG SFGE + NTP + A +P Sbjct: 72 EAVVSVFTRGESFGEAVALRNTPYPVSAEAVTP 104 >4I0B-A nrPDB Length = 222 Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 40/81 (49%), Gaps = 2/81 (2%) Query: 179 VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSF-GELALM-YNTPRAATITA 236 +I QG+ + Y I +G+ + +K + + +Y N+G F GEL L R+A + A Sbjct: 42 LIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRA 101 Query: 237 TSPGALWGLDRVTFRRIIVKN 257 + + + FR++I N Sbjct: 102 KTACEVAEISYKKFRQLIQVN 122 >3KCC-A nrPDB Length = 260 Score = 31.6 bits (70), Expect = 0.63, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 40/81 (49%), Gaps = 2/81 (2%) Query: 179 VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSF-GELALM-YNTPRAATITA 236 +I QG+ + Y I +G+ + +K + + +Y N+G F GEL L R+A + A Sbjct: 80 LIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRA 139 Query: 237 TSPGALWGLDRVTFRRIIVKN 257 + + + FR++I N Sbjct: 140 KTACEVAEISYKKFRQLIQVN 160 >5H3O-A nrPDB Length = 738 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 18/82 (21%), Positives = 42/82 (51%), Gaps = 4/82 (4%) Query: 145 EACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 204 E + + +F++ + +++++ + ++ G+ + +GD G Y++ RG + D Sbjct: 491 ETLRKVRIFQDCEAGLLAELVLKLQLQVFSPGDFICKKGDIGREMYIVKRGRLQV---VD 547 Query: 205 GVGRCVGNYDNRGS-FGELALM 225 G+ V GS FGEL+++ Sbjct: 548 DDGKKVFVTLQEGSVFGELSIL 569 Score = 28.9 bits (63), Expect = 4.5, Method: Compositional matrix adjust. Identities = 15/62 (24%), Positives = 32/62 (51%), Gaps = 9/62 (14%) Query: 293 KVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELA 352 +V++ G+ I +GD+ +IV+ G +++ V+++G G FGEL+ Sbjct: 517 QVFSPGDFICKKGDIGREMYIVKRGRLQV---------VDDDGKKVFVTLQEGSVFGELS 567 Query: 353 LV 354 ++ Sbjct: 568 IL 569 >5I62-A nrPDB Length = 534 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 27/66 (40%), Gaps = 13/66 (19%) Query: 207 GRCVGNYDNRGSFGELALM--YNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKM 264 G CVG Y + G LA+ Y P +WG VT R + + N K + Sbjct: 411 GMCVGVYSTMRALGRLAMQERYYDP-----------DVWGEKMVTLRYLSIIENVKYHPL 459 Query: 265 YESFIE 270 E F++ Sbjct: 460 KEEFLD 465 >1DK5-A nrPDB Length = 322 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 20/71 (28%), Positives = 33/71 (46%), Gaps = 6/71 (8%) Query: 127 AESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDG 186 AES+I+H K D+ A D + + L +Q+ + + GE ++ Q +DG Sbjct: 178 AESKILHEKISDK------AYSDDEVIRILATRSKAQLNATLNHYKDEHGEDILKQLEDG 231 Query: 187 DNFYVIDRGTF 197 D F + R T Sbjct: 232 DEFVALLRATI 242 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4X6Q-B nrPDB 614 e-176 3J4Q-B nrPDB 527 e-150 1CX4-A nrPDB 449 e-126 4DIN-B nrPDB 435 e-122 2QVS-B nrPDB 426 e-120 6BYS-B nrPDB 397 e-111 2QCS-B nrPDB 352 1e-97 5KBF-A nrPDB 343 7e-95 5J3U-A nrPDB 312 2e-85 5FET-A nrPDB 299 1e-81 5DYK-A nrPDB 297 5e-81 6FTF-B nrPDB 292 2e-79 4Z07-A nrPDB 292 2e-79 3SHR-A nrPDB 282 2e-76 5JAX-A nrPDB 156 2e-38 4QX5-A nrPDB 155 3e-38 6BQ8-A nrPDB 140 1e-33 4MGY-E nrPDB 139 2e-33 1O7F-A nrPDB 139 2e-33 4F7Z-A nrPDB 134 5e-32 5V4S-A nrPDB 133 2e-31 6CJQ-A nrPDB 128 4e-30 5JON-A nrPDB 124 7e-29 4CHV-A nrPDB 122 4e-28 3DKW-A nrPDB 117 1e-26 4EV0-A nrPDB 113 1e-25 4AVC-A nrPDB 81 6e-16 5XBY-A nrPDB 80 2e-15 5H78-A nrPDB 79 2e-15 5H77-A nrPDB 77 1e-14 Sequences not found previously or not previously below threshold: 5U6P-A nrPDB 119 2e-27 4ORF-A nrPDB 86 3e-17 4CYD-A nrPDB 85 6e-17 3I59-A nrPDB 84 7e-17 5H3O-A nrPDB 77 2e-14 4I0B-A nrPDB 74 1e-13 3KCC-A nrPDB 74 1e-13 3E97-A nrPDB 73 3e-13 5W5B-A nrPDB 66 3e-11 5VA1-A nrPDB 63 2e-10 2N7G-A nrPDB 63 3e-10 2OZ6-A nrPDB 62 4e-10 3H3Z-A nrPDB 61 1e-09 3UKN-A nrPDB 59 2e-09 5K7L-A nrPDB 56 3e-08 4F8A-A nrPDB 56 3e-08 3IWZ-A nrPDB 53 4e-07 4L11-A nrPDB 52 5e-07 2D93-A nrPDB 47 1e-05 3B02-A nrPDB 47 1e-05 2XKO-A nrPDB 46 2e-05 3LA7-A nrPDB 46 4e-05 1ZYB-A nrPDB 45 5e-05 2GAU-A nrPDB 45 7e-05 2FMY-A nrPDB 43 2e-04 1O5L-A nrPDB 41 7e-04 2ZCW-A nrPDB 39 0.004 1ATT-A nrPDB 37 0.019 4EB1-I nrPDB 36 0.027 5E44-A nrPDB 36 0.028 3E6B-A nrPDB 34 0.089 4FHA-A nrPDB 33 0.21 1Z5V-A nrPDB 32 0.50 1XKW-A nrPDB 32 0.52 6CXO-A nrPDB 29 3.0 5MMI-U nrPDB 29 4.4 >4X6Q-B nrPDB Length = 416 Score = 614 bits (1582), Expect = e-176, Method: Composition-based stats. Identities = 415/416 (99%), Positives = 416/416 (100%) Query: 1 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGD 60 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGD Sbjct: 1 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGD 60 Query: 61 AGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNP 120 AGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNP Sbjct: 61 AGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNP 120 Query: 121 DEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVI 180 DEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVI Sbjct: 121 DEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVI 180 Query: 181 DQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPG 240 DQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTP+AATITATSPG Sbjct: 181 DQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPKAATITATSPG 240 Query: 241 ALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQ 300 ALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQ Sbjct: 241 ALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQ 300 Query: 301 IIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRA 360 IIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRA Sbjct: 301 IIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRA 360 Query: 361 ASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA 416 ASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA Sbjct: 361 ASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA 416 >3J4Q-B nrPDB Length = 402 Score = 527 bits (1357), Expect = e-150, Method: Composition-based stats. Identities = 275/413 (66%), Positives = 328/413 (79%), Gaps = 17/413 (4%) Query: 3 IEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAG 62 I+IPAGLTELLQG+TVEVLR QP DL++FA+++FTRL+ E R+ + F T+ Sbjct: 4 IQIPAGLTELLQGYTVEVLRQQPPDLVDFAVEYFTRLR-EARRQESDTFIVSPTTFHTQE 62 Query: 63 AAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDE 122 ++A I E+GE + +E PV ++FTRR SVCAE +NPDE Sbjct: 63 SSAVPVI---------------EEDGESDSDSEDADLEVPVPSKFTRRVSVCAETFNPDE 107 Query: 123 EEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQ 182 EE+D + R++HPKTD+QR RLQEACKDILLFKNLD EQ+SQVLDAMFEK+VK EHVIDQ Sbjct: 108 EEEDNDPRVVHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFEKIVKTDEHVIDQ 167 Query: 183 GDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGAL 242 GDDGDNFYVI+RGT+DI V D R VG YDNRGSFGELALMYNTPRAATI ATS G+L Sbjct: 168 GDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIIATSEGSL 227 Query: 243 WGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQII 302 WGLDRVTFRRIIVKNNAKKRKM+ESFIES+P KSLE+SER+K+VDVIG K+Y DGE+II Sbjct: 228 WGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGERII 287 Query: 303 AQGDLADSFFIVESGEVKITMKRKGKS-EVEENGAVEIARCFRGQYFGELALVTNKPRAA 361 AQG+ ADSF+I+ESGEV I ++ K KS + N VEIA C +GQYFGELALVTNKPRAA Sbjct: 288 AQGEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYFGELALVTNKPRAA 347 Query: 362 SAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEP 414 SA+A+G VKCL MDVQAFERLLGPCM+IMKRNI+ YEEQLV +FG+N+D+++P Sbjct: 348 SAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSNLDLMDP 400 >1CX4-A nrPDB Length = 305 Score = 449 bits (1155), Expect = e-126, Method: Composition-based stats. Identities = 300/305 (98%), Positives = 303/305 (99%) Query: 112 SVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEK 171 SVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEK Sbjct: 1 SVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEK 60 Query: 172 LVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRA 231 LVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRA Sbjct: 61 LVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRA 120 Query: 232 ATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIG 291 ATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIG Sbjct: 121 ATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIG 180 Query: 292 TKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGEL 351 TKVYNDGEQIIAQGD ADSFFIVESGEV+ITMKRKGKS++EENGAVEIARC RGQYFGEL Sbjct: 181 TKVYNDGEQIIAQGDSADSFFIVESGEVRITMKRKGKSDIEENGAVEIARCLRGQYFGEL 240 Query: 352 ALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDI 411 ALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDI Sbjct: 241 ALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDI 300 Query: 412 VEPTA 416 VEPTA Sbjct: 301 VEPTA 305 >4DIN-B nrPDB Length = 381 Score = 435 bits (1117), Expect = e-122, Method: Composition-based stats. Identities = 144/390 (36%), Positives = 209/390 (53%), Gaps = 42/390 (10%) Query: 8 GLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAGAAAGG 67 G+ ++L+ V + +P ++F +HF +L++E R+ AR Sbjct: 26 GIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILAR----------------- 68 Query: 68 GIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDA 127 +S+S++ +E N PV+ RR V AE Y EE+ + Sbjct: 69 -------------QKSNSQSDSHDEEVSPTPPN-PVVKARRRRGGVSAEVYT--EEDAVS 112 Query: 128 ESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGD 187 R + PK L +A +LF +LD + S + DAMF GE VI QG++GD Sbjct: 113 YVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGD 172 Query: 188 NFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDR 247 NFYV+D+G D+YV + V N GSFGELAL+Y TPRAAT+ A + LWG+DR Sbjct: 173 NFYVVDQGEVDVYVNGE----WVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDR 228 Query: 248 VTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDL 307 ++RRI++ + +KRKMYE F+ + L+SLE ERL V D + + DGE+I+ QG+ Sbjct: 229 DSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEP 288 Query: 308 ADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIG 367 D F+I+ G + +R E VE+ R YFGE+AL+ N+PRAA+ A G Sbjct: 289 GDDFYIITEGTASVLQRRSPNEEY-----VEVGRLGPSDYFGEIALLLNRPRAATVVARG 343 Query: 368 TVKCLAMDVQAFERLLGPCMEIMKRNIATY 397 +KC+ +D FER+LGPC EI+KRNI Y Sbjct: 344 PLKCVKLDRPRFERVLGPCSEILKRNIQRY 373 >2QVS-B nrPDB Length = 310 Score = 426 bits (1096), Expect = e-120, Method: Composition-based stats. Identities = 233/308 (75%), Positives = 268/308 (87%), Gaps = 1/308 (0%) Query: 108 TRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDA 167 TRR SVCAE +NPDEEE+D + R++HPKTD+QR RLQEACKDILLFKNLD EQ+SQVLDA Sbjct: 1 TRRVSVCAETFNPDEEEEDNDPRVVHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDA 60 Query: 168 MFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYN 227 MFEK+VK EHVIDQGDDGDNFYVI+RGT+DI V D R VG YDNRGSFGELALMYN Sbjct: 61 MFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYN 120 Query: 228 TPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVV 287 TPRAATI ATS G+LWGLDRVTFRRIIVKNNAKKRKM+ESFIES+P KSLE+SER+K+V Sbjct: 121 TPRAATIIATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIV 180 Query: 288 DVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKS-EVEENGAVEIARCFRGQ 346 DVIG K+Y DGE+IIAQG+ ADSF+I+ESGEV I ++ K KS + N VEIA C +GQ Sbjct: 181 DVIGEKIYKDGERIIAQGEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQ 240 Query: 347 YFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFG 406 YFGELALVTNKPRAASA+ +G VKCL MDVQAFERLLGPCM+IMKRNI+ YEEQLV +FG Sbjct: 241 YFGELALVTNKPRAASAYGVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFG 300 Query: 407 TNMDIVEP 414 +N+D+++P Sbjct: 301 SNLDLMDP 308 >6BYS-B nrPDB Length = 379 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 136/389 (34%), Positives = 203/389 (52%), Gaps = 42/389 (10%) Query: 9 LTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAGAAAGGG 68 + LL+ V++ +P + F ++F +L++E ++ Sbjct: 25 IQALLKDSIVQLCTARPERPMAFLREYFEKLEKEEAKQIQN------------------- 65 Query: 69 IPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAE 128 ++ S E+ N PV+ RR ++ AE Y EE+ + Sbjct: 66 -----------LQKAGSRADSREDEISPPPPN-PVVKGRRRRGAISAEVYT--EEDAASY 111 Query: 129 SRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDN 188 R + PK L +A + +LF +LD + S + DAMF GE VI QGD+GDN Sbjct: 112 VRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDN 171 Query: 189 FYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRV 248 FYVID+G D+YV + + GSFGELAL+Y TPRAAT+ A + LWG+DR Sbjct: 172 FYVIDQGEMDVYVNNE----WATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRD 227 Query: 249 TFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLA 308 ++RRI++ + +KRKMYE F+ + L+SL+ ERL V D + + DG++I+ QG+ Sbjct: 228 SYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPG 287 Query: 309 DSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGT 368 D FFI+ G + +R E VE+ R YFGE+AL+ N+PRAA+ A G Sbjct: 288 DEFFIILEGSAAVLQRRSENEE-----FVEVGRLGPSDYFGEIALLMNRPRAATVVARGP 342 Query: 369 VKCLAMDVQAFERLLGPCMEIMKRNIATY 397 +KC+ +D FER+LGPC +I+KRNI Y Sbjct: 343 LKCVKLDRPRFERVLGPCSDILKRNIQQY 371 Score = 111 bits (276), Expect = 9e-25, Method: Composition-based stats. Identities = 46/177 (25%), Positives = 79/177 (44%), Gaps = 6/177 (3%) Query: 100 NAPVINRFTRRASVCAEA-YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDP 158 +I R A+V A+ + D+ RI+ T +R +E + + ++LD Sbjct: 200 ELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDK 259 Query: 159 EQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNY--DNR 216 + V DA+ ++G+ ++ QG+ GD F++I G+ + + V Sbjct: 260 WERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPS 319 Query: 217 GSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIV---KNNAKKRKMYESFIE 270 FGE+AL+ N PRAAT+ A P LDR F R++ + + Y SF+ Sbjct: 320 DYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 376 >2QCS-B nrPDB Length = 291 Score = 352 bits (903), Expect = 1e-97, Method: Composition-based stats. Identities = 122/293 (41%), Positives = 173/293 (59%), Gaps = 11/293 (3%) Query: 105 NRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQV 164 RR ++ AE Y EE+ + R + PK L +A + +LF +LD + S + Sbjct: 1 KGRRRRGAISAEVYT--EEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDI 58 Query: 165 LDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELAL 224 DAMF GE VI QGD+GDNFYVID+G D+YV + + GSFGELAL Sbjct: 59 FDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNE----WATSVGEGGSFGELAL 114 Query: 225 MYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERL 284 +Y TPRAAT+ A + LWG+DR ++RRI++ + +KRKMYE F+ + L+SL+ ERL Sbjct: 115 IYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERL 174 Query: 285 KVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFR 344 V D + + DG++I+ QG+ D FFI+ G + +R E VE+ R Sbjct: 175 TVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEE-----FVEVGRLGP 229 Query: 345 GQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATY 397 YFGE+AL+ N+P+AA+ A G +KC+ +D FER+LGPC +I+KRNI Y Sbjct: 230 SDYFGEIALLMNRPKAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQY 282 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 45/177 (25%), Positives = 79/177 (44%), Gaps = 6/177 (3%) Query: 100 NAPVINRFTRRASVCAEA-YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDP 158 +I R A+V A+ + D+ RI+ T +R +E + + ++LD Sbjct: 111 ELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDK 170 Query: 159 EQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNY--DNR 216 + V DA+ ++G+ ++ QG+ GD F++I G+ + + V Sbjct: 171 WERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPS 230 Query: 217 GSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIV---KNNAKKRKMYESFIE 270 FGE+AL+ N P+AAT+ A P LDR F R++ + + Y SF+ Sbjct: 231 DYFGEIALLMNRPKAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVS 287 >5KBF-A nrPDB Length = 301 Score = 343 bits (880), Expect = 7e-95, Method: Composition-based stats. Identities = 113/300 (37%), Positives = 174/300 (58%), Gaps = 12/300 (4%) Query: 106 RFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVL 165 +R SV AEAY ++ D ++ K + ++ +++EA + LF +L+ ++ ++ Sbjct: 3 GQKKRLSVSAEAYGDWNKKIDNFIPKVYKKDEKEKAKIREALNESFLFNHLNKKEFEIIV 62 Query: 166 DAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VKCDGVGRCVGNYDNRGSFGELAL 224 +A F+K V++G ++I++GD GD YVID+G +IY K + + ++ FGELAL Sbjct: 63 NAFFDKNVEKGVNIINEGDYGDLLYVIDQGEVEIYKTKENNKKEVLTVLKSKDVFGELAL 122 Query: 225 MYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERL 284 +YN+ RAAT TA + LW LDR +F II AKKRKMYE + + LK ++ ER Sbjct: 123 LYNSKRAATATALTKCHLWALDRESFTYIIKDMVAKKRKMYEDILSHVNILKDMDPYERC 182 Query: 285 KVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFR 344 KV D + +K YNDGE II +G+ D+FFI+ G + K I + Sbjct: 183 KVADCLKSKSYNDGEIIIKEGEEGDTFFILIDGNAVASKDNKV-----------IKTYTK 231 Query: 345 GQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVAL 404 G YFGELAL+ NKPRAA+ A + + +D ++F+RLLGP +I+ RN+ Y++ L L Sbjct: 232 GDYFGELALLKNKPRAATIKAQNFCQVVYLDRKSFKRLLGPIEDILHRNVENYKKVLNEL 291 >5J3U-A nrPDB Length = 261 Score = 312 bits (798), Expect = 2e-85, Method: Composition-based stats. Identities = 95/266 (35%), Positives = 151/266 (56%), Gaps = 5/266 (1%) Query: 132 IHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYV 191 ++ K + Q+ +L+ + LF +LD + ++ V+ AM EK ++ +I +GDDG+ Y+ Sbjct: 1 VYEKDEGQKEQLERILRQSFLFNSLDEKDLNTVILAMQEKKIEASTCLIREGDDGECLYI 60 Query: 192 IDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFR 251 + G + DG R V +FGELAL+YN PRAAT+T+ S LW L R TF Sbjct: 61 VQSGELNCSKLIDGEERVVKVVGPGDAFGELALLYNAPRAATVTSVSACDLWELGRDTFN 120 Query: 252 RIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSF 311 I+ K+R MY+SF++S+ L ++ ER KV D + T+++ DG I+ QG+L D F Sbjct: 121 AIVKDAATKRRSMYDSFLKSVHILDGMDAYERGKVADALRTEMFTDGAYIVRQGELGDVF 180 Query: 312 FIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKC 371 +IVE G T KS +E+ + G YFGELAL+ +PRAA+ A G K Sbjct: 181 YIVEEGSAVAT-----KSFGPGQPPIEVKKYQAGDYFGELALINEEPRAANVIAHGICKV 235 Query: 372 LAMDVQAFERLLGPCMEIMKRNIATY 397 ++ ++F+RL+G +++ + + Y Sbjct: 236 ACLERKSFKRLMGSVQDLLSKKASEY 261 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 47/174 (27%), Positives = 83/174 (47%), Gaps = 14/174 (8%) Query: 99 FNAPVINRFTRRASVCA-EAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLD 157 +NAP R A+V + A + E D + I+ +R+ K + + +D Sbjct: 95 YNAP------RAATVTSVSACDLWELGRDTFNAIVKDAATKRRSMYDSFLKSVHILDGMD 148 Query: 158 PEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGR---CVGNYD 214 + +V DA+ ++ +G +++ QG+ GD FY+++ G+ + K G G+ V Y Sbjct: 149 AYERGKVADALRTEMFTDGAYIVRQGELGDVFYIVEEGSA-VATKSFGPGQPPIEVKKYQ 207 Query: 215 NRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRII---VKNNAKKRKMY 265 FGELAL+ PRAA + A + L+R +F+R++ +KK Y Sbjct: 208 AGDYFGELALINEEPRAANVIAHGICKVACLERKSFKRLMGSVQDLLSKKASEY 261 >5FET-A nrPDB Length = 847 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 82/282 (29%), Positives = 141/282 (50%), Gaps = 18/282 (6%) Query: 124 EDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQG 183 ED + R K + ++ + K+ L+ L+ ++ + + M + K G+ VI QG Sbjct: 27 EDHLQLR---EKLSEDIEMIKASLKNNLVCSTLNDNEILTLSNYMQFFVFKGGDLVIKQG 83 Query: 184 DDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALW 243 + G F++I+ G FD+YV + V + SFGE AL++NT R+ATI A + G LW Sbjct: 84 EKGSYFFIINSGKFDVYVN----DKKVKSMGKGSSFGEAALIHNTQRSATIMAETDGTLW 139 Query: 244 GLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIA 303 G+ R TFR + + + + SFI+S+ L +++ + + +++ GE I+ Sbjct: 140 GVQRSTFRATLKQLSNRNFNENRSFIDSVSVFDMLTEAQKNMITNACVIQMFKPGETIVK 199 Query: 304 QGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASA 363 QGD D FI++ G+ + + K EI +G YFGE AL+ ++PR+A+ Sbjct: 200 QGDYGDVLFILKEGKATVFINDK-----------EIRVLNKGSYFGERALLYDEPRSATI 248 Query: 364 HAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALF 405 A C ++ + +LG ++ RNI T Q +F Sbjct: 249 IAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIF 290 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 112/262 (42%), Gaps = 22/262 (8%) Query: 140 RNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFY-VIDRGTFD 198 RN + EA + +F+ EQ++ + D + H++ + Y ++ G + Sbjct: 277 RNIMTEALQQSEIFRQFSAEQLNDLADTAIVRDYPANYHILHKDKVKSVKYLIVLEGKVE 336 Query: 199 IYVKCDGVGRCVGNYDNRGSFGELALMYNTPR-AATITATSPGALWGLDRVTFRRIIVKN 257 +++ +G SFG+ ++ + T+ + + + + N Sbjct: 337 LFL----DDESIGILTRGKSFGDQYVLNQKQKFRHTVKSLDVCKIALITESCLADCLGDN 392 Query: 258 NA---KKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIV 314 N +S I+ + + L + +++ T Y +G+ II +G++ F+I+ Sbjct: 393 NIDASIDHNNKKSIIKKMYIFRYLSEQQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYII 452 Query: 315 ESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHA-IGTVKCLA 373 ++GEV++T K + + YFGE AL+ ++PR AS + +V+C Sbjct: 453 KNGEVEVTKNGK-----------RLRTLGKNDYFGERALLYDEPRTASIISKATSVECWF 501 Query: 374 MDVQAFERLL-GPCMEIMKRNI 394 +D F +++ GP + ++ I Sbjct: 502 VDKSVFLQIIQGPMLTHLEERI 523 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 52/289 (17%), Positives = 110/289 (38%), Gaps = 19/289 (6%) Query: 100 NAPVINRFTRRASVCAEA-YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDP 158 A +I+ R A++ AE + + ++ N + + +F L Sbjct: 117 EAALIHNTQRSATIMAETDGTLWGVQRSTFRATLKQLSNRNFNENRSFIDSVSVFDMLTE 176 Query: 159 EQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGS 218 Q + + +A ++ K GE ++ QGD GD +++ G +++ + + + Sbjct: 177 AQKNMITNACVIQMFKPGETIVKQGDYGDVLFILKEGKATVFIN----DKEIRVLNKGSY 232 Query: 219 FGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKK-RKMYESFIESLPFLKS 277 FGE AL+Y+ PR+ATI A P A + R ++ R + ++ + Sbjct: 233 FGERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFRQ 292 Query: 278 LEVSERLKVVDVIGTKVYNDGEQIIAQGD-LADSFFIVESGEVKITMKRKGKSEVEENGA 336 + + D + Y I+ + + + IV G+V++ + + Sbjct: 293 FSAEQLNDLADTAIVRDYPANYHILHKDKVKSVKYLIVLEGKVELFLDDES--------- 343 Query: 337 VEIARCFRGQYFGELALVTNKPR-AASAHAIGTVKCLAMDVQAFERLLG 384 I RG+ FG+ ++ K + + ++ K + LG Sbjct: 344 --IGILTRGKSFGDQYVLNQKQKFRHTVKSLDVCKIALITESCLADCLG 390 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 46/200 (23%), Positives = 84/200 (42%), Gaps = 29/200 (14%) Query: 110 RASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMF 169 + ++ E+ D D+ I N + K + +F+ L +Q + +++A Sbjct: 376 KIALITESCLADCLGDNNIDASI------DHNNKKSIIKKMYIFRYLSEQQCNLLIEAFR 429 Query: 170 EKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTP 229 +EG+++I +G+ G FY+I G ++ + + FGE AL+Y+ P Sbjct: 430 TTRYEEGDYIIQEGEVGSRFYIIKNGEVEVTKNG----KRLRTLGKNDYFGERALLYDEP 485 Query: 230 RAATITA-TSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVD 288 R A+I + + W +D+ F +II P L LE ER+K+ D Sbjct: 486 RTASIISKATSVECWFVDKSVFLQIIQG----------------PMLTHLE--ERIKMQD 527 Query: 289 VIGTKVYNDGEQIIAQGDLA 308 + E+II +G Sbjct: 528 TKVEMHELETERIIGRGTFG 547 >5DYK-A nrPDB Length = 853 Score = 297 bits (760), Expect = 5e-81, Method: Composition-based stats. Identities = 80/282 (28%), Positives = 139/282 (49%), Gaps = 18/282 (6%) Query: 124 EDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQG 183 ED E R K + + ++ + K+ L+ L+ ++ + + M + K G VI QG Sbjct: 33 EDHLELR---EKLSEDIDMIKTSLKNNLVCSTLNDNEILTLSNYMQFFVFKSGNLVIKQG 89 Query: 184 DDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALW 243 + G F++I+ G FD+YV + V SFGE AL++NT R+ATI A + G LW Sbjct: 90 EKGSYFFIINSGKFDVYVN----DKKVKTMGKGSSFGEAALIHNTQRSATIIAETDGTLW 145 Query: 244 GLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIA 303 G+ R TFR + + + + +FI+S+ L +++ + + + + GE I+ Sbjct: 146 GVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDMLTEAQKNMITNACVIQNFKSGETIVK 205 Query: 304 QGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASA 363 QGD D +I++ G+ + + + EI +G YFGE AL+ ++PR+A+ Sbjct: 206 QGDYGDVLYILKEGKATVYINDE-----------EIRVLEKGSYFGERALLYDEPRSATI 254 Query: 364 HAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALF 405 A C ++ + +LG ++ RNI T Q +F Sbjct: 255 IAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIF 296 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 55/290 (18%), Positives = 107/290 (36%), Gaps = 19/290 (6%) Query: 100 NAPVINRFTRRASVCAEA-YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDP 158 A +I+ R A++ AE + + ++ N + + +F L Sbjct: 123 EAALIHNTQRSATIIAETDGTLWGVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDMLTE 182 Query: 159 EQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGS 218 Q + + +A + K GE ++ QGD GD Y++ G +Y+ + + + Sbjct: 183 AQKNMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYINDEE----IRVLEKGSY 238 Query: 219 FGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKK-RKMYESFIESLPFLKS 277 FGE AL+Y+ PR+ATI A P A + R ++ R + ++ K Sbjct: 239 FGERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFKQ 298 Query: 278 LEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVE-SGEVKITMKRKGKSEVEENGA 336 + + D + Y I+ + + +I+ G+V++ + Sbjct: 299 FSGDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVELFLDD----------- 347 Query: 337 VEIARCFRGQYFGELALVTNK-PRAASAHAIGTVKCLAMDVQAFERLLGP 385 I RG FG+ ++ K P + ++ K + LG Sbjct: 348 TSIGILSRGMSFGDQYVLNQKQPFKHTIKSLEVCKIALITETCLADCLGN 397 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 53/262 (20%), Positives = 112/262 (42%), Gaps = 22/262 (8%) Query: 140 RNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVI-DRGTFD 198 RN + EA + +FK +Q++ + D + +++ + Y+I G + Sbjct: 283 RNIMTEALQQSEIFKQFSGDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVE 342 Query: 199 IYVKCDGVGRCVGNYDNRGSFGELALMYN-TPRAATITATSPGALWGLDRVTFRRIIVKN 257 +++ +G SFG+ ++ P TI + + + + N Sbjct: 343 LFL----DDTSIGILSRGMSFGDQYVLNQKQPFKHTIKSLEVCKIALITETCLADCLGNN 398 Query: 258 NA---KKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIV 314 N +S I+ + + L + +++ T Y +G+ II +G++ F+I+ Sbjct: 399 NIDASIDYNNKKSIIKKMYIFRYLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYII 458 Query: 315 ESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHA-IGTVKCLA 373 ++GEV+I +K + + YFGE AL+ ++PR AS + + V+C Sbjct: 459 KNGEVEIVKNKK-----------RLRTLGKNDYFGERALLYDEPRTASVISKVNNVECWF 507 Query: 374 MDVQAFERLL-GPCMEIMKRNI 394 +D F +++ GP + ++ I Sbjct: 508 VDKSVFLQIIQGPMLAHLEERI 529 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 42/169 (24%), Positives = 74/169 (43%), Gaps = 23/169 (13%) Query: 141 NRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY 200 N + K + +F+ L +Q + +++A +EG+++I +G+ G FY+I G +I Sbjct: 407 NNKKSIIKKMYIFRYLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIV 466 Query: 201 VKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS-PGALWGLDRVTFRRIIVKNNA 259 + + FGE AL+Y+ PR A++ + W +D+ F +II Sbjct: 467 KN----KKRLRTLGKNDYFGERALLYDEPRTASVISKVNNVECWFVDKSVFLQIIQG--- 519 Query: 260 KKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLA 308 P L LE ER+K+ D + E+II +G Sbjct: 520 -------------PMLAHLE--ERIKMQDTKVEMDELETERIIGRGTFG 553 >6FTF-B nrPDB Length = 304 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 137/289 (47%), Gaps = 14/289 (4%) Query: 106 RFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVL 165 RR +V +E +P E+ K++D+ N + + +LF L+ + + V Sbjct: 1 GRNRRRTVRSEGIDP--EKAKLYQAPYFEKSEDEMNLITKLLTHNVLFSFLNTKDIKVVA 58 Query: 166 DAMFEKLVKEGEHVIDQGDDGDN-FYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELAL 224 AM K + +++ G N Y+I G DI +G + + GEL L Sbjct: 59 GAMQRATFKHDDCIMEAGQTTCNKLYIIQSGHADII--KEGQKVYLKT--EGTAVGELEL 114 Query: 225 MYNTPRAATITATSPGAL-WGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSER 283 MY+TP AT+ + + W LDR T+R +++ ++R+ Y F+ ++PFL L+ E+ Sbjct: 115 MYDTPVVATVKVCTDELIAWVLDRDTYRNLVMGTAIRRRETYIQFLANVPFLGGLDSYEK 174 Query: 284 LKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCF 343 L++ D + ++ ++ GE II G+ + +I+ G V++ + + ++ Sbjct: 175 LQLADALSSEEFSPGEYIIHYGEEGEWLYIIMEGTVEVIGRD------ADGEPTKVCEFT 228 Query: 344 RGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKR 392 +G + GEL + N A A V ++ + FE LGP ++++KR Sbjct: 229 QGDHIGELEFLNNHRTVADVVATTHVITAKLNRRHFEMCLGPVIDVLKR 277 >4Z07-A nrPDB Length = 262 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 78/259 (30%), Positives = 128/259 (49%), Gaps = 9/259 (3%) Query: 131 IIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFY 190 +PK+ ++ ++EA D KNL+ Q+ +++D M+ + +I +GD G Y Sbjct: 8 PFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVY 67 Query: 191 VIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTF 250 V++ G ++ +GV C FGELA++YN R AT+ LW +DR F Sbjct: 68 VMEDGKVEV--TKEGVKLC--TMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCF 123 Query: 251 RRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADS 310 + I+++ K Y F++S+P +SL K+ DV+ Y +GE II QG D+ Sbjct: 124 QTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDT 183 Query: 311 FFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVK 370 FFI+ G V +T + + V + +G +FGE AL R A+ A V Sbjct: 184 FFIISKGTVNVT-----REDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT 238 Query: 371 CLAMDVQAFERLLGPCMEI 389 CL +D +F+ L+G ++ Sbjct: 239 CLVIDRDSFKHLIGGLDDV 257 Score = 127 bits (319), Expect = 8e-30, Method: Composition-based stats. Identities = 39/162 (24%), Positives = 66/162 (40%), Gaps = 5/162 (3%) Query: 108 TRRASVCAEA-YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLD 166 TR A+V + I+ + E K + F++L E +S++ D Sbjct: 102 TRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLAD 161 Query: 167 AMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGR---CVGNYDNRGSFGELA 223 + E + GE++I QG GD F++I +GT ++ + D + FGE A Sbjct: 162 VLEETHYENGEYIIRQGARGDTFFIISKGTVNV-TREDSPSEDPVFLRTLGKGDWFGEKA 220 Query: 224 LMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMY 265 L R A + A +DR +F+ +I + K Y Sbjct: 221 LQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAY 262 >3SHR-A nrPDB Length = 299 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 77/257 (29%), Positives = 128/257 (49%), Gaps = 9/257 (3%) Query: 133 HPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVI 192 K++ ++ ++EA D KNL+ Q+ +++D M+ + +I +GD G YV+ Sbjct: 27 FTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVM 86 Query: 193 DRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRR 252 + G ++ +GV C FGELA++YN R AT+ LW +DR F+ Sbjct: 87 EDGKVEV--TKEGVKLC--TMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQT 142 Query: 253 IIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFF 312 I+++ K Y F++S+P +SL K+ DV+ Y +GE II QG D+FF Sbjct: 143 IMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFF 202 Query: 313 IVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCL 372 I+ G+V +T + + V + +G +FGE AL R A+ A V CL Sbjct: 203 IISKGKVNVT-----REDSPNEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCL 257 Query: 373 AMDVQAFERLLGPCMEI 389 +D +F+ L+G ++ Sbjct: 258 VIDRDSFKHLIGGLDDV 274 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 38/163 (23%), Positives = 65/163 (39%), Gaps = 3/163 (1%) Query: 108 TRRASVCAEA-YNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLD 166 TR A+V + I+ + E K + F++L E +S++ D Sbjct: 119 TRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLAD 178 Query: 167 AMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYV--KCDGVGRCVGNYDNRGSFGELAL 224 + E + GE++I QG GD F++I +G ++ + + FGE AL Sbjct: 179 VLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFLRTLGKGDWFGEKAL 238 Query: 225 MYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYES 267 R A + A +DR +F+ +I + K YE Sbjct: 239 QGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYED 281 >5JAX-A nrPDB Length = 135 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 41/133 (30%), Positives = 63/133 (47%), Gaps = 5/133 (3%) Query: 257 NNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVES 316 K Y F++S+P +SL K+ DV+ Y +GE II QG D+FFI+ Sbjct: 3 TGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISK 62 Query: 317 GEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDV 376 G V +T + + V + +G +FGE AL R A+ A V CL +D Sbjct: 63 GTVNVT-----REDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDR 117 Query: 377 QAFERLLGPCMEI 389 +F+ L+G ++ Sbjct: 118 DSFKHLIGGLDDV 130 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 34/130 (26%), Positives = 58/130 (44%), Gaps = 4/130 (3%) Query: 139 QRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFD 198 + E K + F++L E +S++ D + E + GE++I QG GD F++I +GT + Sbjct: 7 KHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVN 66 Query: 199 IYVKCDGVGR---CVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIV 255 + + D + FGE AL R A + A +DR +F+ +I Sbjct: 67 V-TREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIG 125 Query: 256 KNNAKKRKMY 265 + K Y Sbjct: 126 GLDDVSNKAY 135 >4QX5-A nrPDB Length = 153 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 41/133 (30%), Positives = 63/133 (47%), Gaps = 5/133 (3%) Query: 257 NNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVES 316 K Y F++S+P +SL K+ DV+ Y +GE II QG D+FFI+ Sbjct: 3 TGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISK 62 Query: 317 GEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDV 376 G V +T + + V + +G +FGE AL R A+ A V CL +D Sbjct: 63 GTVNVT-----REDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDR 117 Query: 377 QAFERLLGPCMEI 389 +F+ L+G ++ Sbjct: 118 DSFKHLIGGLDDV 130 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 35/132 (26%), Positives = 59/132 (44%), Gaps = 4/132 (3%) Query: 139 QRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFD 198 + E K + F++L E +S++ D + E + GE++I QG GD F++I +GT + Sbjct: 7 KHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVN 66 Query: 199 IYVKCDGVGR---CVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIV 255 + + D + FGE AL R A + A +DR +F+ +I Sbjct: 67 V-TREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIG 125 Query: 256 KNNAKKRKMYES 267 + K YE Sbjct: 126 GLDDVSNKAYED 137 >6BQ8-A nrPDB Length = 152 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 40/132 (30%), Positives = 73/132 (55%), Gaps = 6/132 (4%) Query: 261 KRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVK 320 + + Y +F+ S+ LK+L + K++D + + Y+ G+ II +G+ +FFI+ G+VK Sbjct: 7 RDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVK 66 Query: 321 ITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIG-TVKCLAMDVQAF 379 +T +G + I +G+YFGE AL+++ R+A+ A V CL +D + F Sbjct: 67 VTQSTEGH-----DQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETF 121 Query: 380 ERLLGPCMEIMK 391 + +G E+ K Sbjct: 122 NQTVGTFEELQK 133 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 26/118 (22%), Positives = 60/118 (50%), Gaps = 3/118 (2%) Query: 141 NRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY 200 + + + + L KNL +++++++D + + +G+++I +G++G F+++ +G + Sbjct: 9 EQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVT 68 Query: 201 VKCDGVG--RCVGNYDNRGSFGELALMYNTPRAATITATS-PGALWGLDRVTFRRIIV 255 +G + + FGE AL+ + R+A I A A +DR TF + + Sbjct: 69 QSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVG 126 >4MGY-E nrPDB Length = 694 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 44/162 (27%), Positives = 78/162 (48%), Gaps = 19/162 (11%) Query: 126 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKEGE 177 DA R+I K QR + L+ ++L K L +++ VL +FE K G Sbjct: 8 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 65 Query: 178 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT 237 + +QG++G ++Y+I +G+ ++ + GV + D+ FG+LAL+ + PRAA+I Sbjct: 66 VLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD---FGQLALVNDAPRAASIVLR 122 Query: 238 SP-GALWGLDRVTFRRIIVKNNAKKRKMYES-----FIESLP 273 +D+ F RI+ A ++ E +E +P Sbjct: 123 EDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVP 164 Score = 77.9 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 33/140 (23%), Positives = 58/140 (41%), Gaps = 13/140 (9%) Query: 265 YESFIESLPFLKSLEVSERLKVVDVIGTKVY-NDGEQIIAQGDLADSFFIVESGEVKITM 323 Y+ + + L L + + ++ V+ + + G + QG+ S++I+ G V + + Sbjct: 31 YDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVI 89 Query: 324 KRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGT-VKCLAMDVQAFERL 382 KG + G FG+LALV + PRAAS L +D + F R+ Sbjct: 90 YGKG----------VVCTLHEGDDFGQLALVNDAPRAASIVLREDNCHFLRVDKEDFNRI 139 Query: 383 LGPCMEIMKRNIATYEEQLV 402 L R ++ LV Sbjct: 140 LRDVEANTVRLKEHDQDVLV 159 >1O7F-A nrPDB Length = 469 Score = 139 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 44/162 (27%), Positives = 78/162 (48%), Gaps = 19/162 (11%) Query: 126 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKEGE 177 DA R+I K QR + L+ ++L K L +++ VL +FE K G Sbjct: 313 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 370 Query: 178 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT 237 + +QG++G ++Y+I +G+ ++ + GV + D+ FG+LAL+ + PRAA+I Sbjct: 371 VLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD---FGKLALVNDAPRAASIVLR 427 Query: 238 SP-GALWGLDRVTFRRIIVKNNAKKRKMYES-----FIESLP 273 +D+ F RI+ A ++ E +E +P Sbjct: 428 EDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVP 469 Score = 89.1 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 41/212 (19%), Positives = 85/212 (40%), Gaps = 20/212 (9%) Query: 97 GAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNL 156 G+ P++ + AE ++ ++ + + + K + F+ Sbjct: 1 GSPGIPMVAAHAAHSQSSAEWIACLDKRP-------LERSSEDVDIIFTRLKGVKAFEKF 53 Query: 157 DPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGR---CVGNY 213 P + Q+ + + +++G + QGD G N+Y + G+ D+ V + + Sbjct: 54 HPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTL 113 Query: 214 DNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLP 273 +FGE +++ NTPR ATI L +++ F+ + +K + Y + + + P Sbjct: 114 GIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALW-----EKYRQYMAGLLAPP 167 Query: 274 FLKSLEVSERLKVVDVIGTKVYNDGEQIIAQG 305 + V E D I K E+I+ G Sbjct: 168 Y----GVMETGSNNDRIPDKENVPSEKILRAG 195 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 33/140 (23%), Positives = 58/140 (41%), Gaps = 13/140 (9%) Query: 265 YESFIESLPFLKSLEVSERLKVVDVIGTKVY-NDGEQIIAQGDLADSFFIVESGEVKITM 323 Y+ + + L L + + ++ V+ + + G + QG+ S++I+ G V + + Sbjct: 336 YDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVI 394 Query: 324 KRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGT-VKCLAMDVQAFERL 382 KG + G FG+LALV + PRAAS L +D + F R+ Sbjct: 395 YGKG----------VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRI 444 Query: 383 LGPCMEIMKRNIATYEEQLV 402 L R ++ LV Sbjct: 445 LRDVEANTVRLKEHDQDVLV 464 Score = 65.6 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 47/114 (41%), Gaps = 5/114 (4%) Query: 269 IESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGK 328 ++ + + + ++ + G + QGD+ +++ V +G + + K Sbjct: 44 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDV----KVS 99 Query: 329 SEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERL 382 AV I G FGE +++ N PR A+ + + L ++ + F+ L Sbjct: 100 ETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 152 >4F7Z-A nrPDB Length = 999 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 43/162 (26%), Positives = 77/162 (47%), Gaps = 19/162 (11%) Query: 126 DAESRIIHPKTDDQR--NRLQEACKDILLFKNLD------PEQMSQVLDAMFEKLVKEGE 177 DA R+I K QR + L+ ++L K L +++ VL +FE K G Sbjct: 313 DAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVL--IFESHAKGGT 370 Query: 178 HVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITAT 237 + +QG++G ++Y+I +G+ ++ + GV + D+ FG+LAL+ + PRAA+I Sbjct: 371 VLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD---FGKLALVNDAPRAASIVLR 427 Query: 238 SP-GALWGLDRVTFRRIIVKNNAKKRKMYES-----FIESLP 273 +D+ RI+ A ++ E +E +P Sbjct: 428 EDNCHFLRVDKEDGNRILRDVEANTVRLKEHDQDVLVLEKVP 469 Score = 89.1 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 41/212 (19%), Positives = 85/212 (40%), Gaps = 20/212 (9%) Query: 97 GAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNL 156 G+ P++ + AE ++ ++ + + + K + F+ Sbjct: 1 GSPGIPMVAAHAAHSQSSAEWIACLDKRP-------LERSSEDVDIIFTRLKGVKAFEKF 53 Query: 157 DPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGR---CVGNY 213 P + Q+ + + +++G + QGD G N+Y + G+ D+ V + + Sbjct: 54 HPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTL 113 Query: 214 DNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLP 273 +FGE +++ NTPR ATI L +++ F+ + +K + Y + + + P Sbjct: 114 GIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKALW-----EKYRQYMAGLLAPP 167 Query: 274 FLKSLEVSERLKVVDVIGTKVYNDGEQIIAQG 305 + V E D I K E+I+ G Sbjct: 168 Y----GVMETGSNNDRIPDKENVPSEKILRAG 195 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 32/140 (22%), Positives = 57/140 (40%), Gaps = 13/140 (9%) Query: 265 YESFIESLPFLKSLEVSERLKVVDVIGTKVY-NDGEQIIAQGDLADSFFIVESGEVKITM 323 Y+ + + L L + + ++ V+ + + G + QG+ S++I+ G V + + Sbjct: 336 YDELL-HIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVI 394 Query: 324 KRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGT-VKCLAMDVQAFERL 382 KG + G FG+LALV + PRAAS L +D + R+ Sbjct: 395 YGKG----------VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDGNRI 444 Query: 383 LGPCMEIMKRNIATYEEQLV 402 L R ++ LV Sbjct: 445 LRDVEANTVRLKEHDQDVLV 464 Score = 65.6 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 47/114 (41%), Gaps = 5/114 (4%) Query: 269 IESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGK 328 ++ + + + ++ + G + QGD+ +++ V +G + + K Sbjct: 44 LKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDV----KVS 99 Query: 329 SEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERL 382 AV I G FGE +++ N PR A+ + + L ++ + F+ L Sbjct: 100 ETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESSELLRIEQEDFKAL 152 >5V4S-A nrPDB Length = 465 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 33/155 (21%), Positives = 67/155 (43%), Gaps = 17/155 (10%) Query: 242 LWGLDR---VTFRRIIVKNNA-----KKRKMYESFIESLPFLKSLEVSERLKVVDVIGTK 293 ++ +DR ++ K +++ +E +PFLK + + +V + Sbjct: 305 MYIIDRGWGEDENALLNDLPISLRREVKIQLHRDLLEKVPFLKGADPALVTSLVFSMKPM 364 Query: 294 VYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELAL 353 ++ +G+ I +G+ D +I+ G V I + + + GQ+FGELAL Sbjct: 365 IFLEGDTIFRRGEKGDDLYILSEGSVDIL---------DSDEKTILLSLQEGQFFGELAL 415 Query: 354 VTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCME 388 V + PR+A+ A T + + F+ +L + Sbjct: 416 VMDAPRSATVRATTTCEIYTLSKTDFDNVLKRFSQ 450 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 39/161 (24%), Positives = 76/161 (47%), Gaps = 12/161 (7%) Query: 121 DEEEDDAESR--IIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEH 178 E+++A I + + + ++ + + K DP ++ ++ +M + EG+ Sbjct: 312 WGEDENALLNDLPISLRREVKIQLHRDLLEKVPFLKGADPALVTSLVFSMKPMIFLEGDT 371 Query: 179 VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGN-YDNRGSFGELALMYNTPRAATITAT 237 + +G+ GD+ Y++ G+ DI D + + FGELAL+ + PR+AT+ AT Sbjct: 372 IFRRGEKGDDLYILSEGSVDI---LDSDEKTILLSLQEGQFFGELALVMDAPRSATVRAT 428 Query: 238 SPGALWGLDRVTFRRIIVKNNAKKRKMYESFI-ESLPFLKS 277 + ++ L + F N K+ + S I ES+ LK Sbjct: 429 TTCEIYTLSKTDF-----DNVLKRFSQFRSAIEESVAHLKK 464 >6CJQ-A nrPDB Length = 456 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 33/151 (21%), Positives = 60/151 (39%), Gaps = 10/151 (6%) Query: 259 AKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGE 318 A +++ IE +P K ++ + +Y GE II G++ + + G Sbjct: 305 AVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIYGPGEYIIRAGEMGSDVYFINRGS 364 Query: 319 VKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQA 378 V++ + A GQ+FGE+AL+ PR A+ A +D + Sbjct: 365 VEVL---------SADEKTRYAILSEGQFFGEMALILRAPRTATVRARAFCDLYRLDKET 415 Query: 379 FERLLGPCMEIMKRNIATYEEQLVALFGTNM 409 F+R+L EI + I + L + + Sbjct: 416 FDRILSRYPEIAAQ-IQELAVRRKELESSGL 445 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 40/163 (24%), Positives = 69/163 (42%), Gaps = 17/163 (10%) Query: 120 PDEEEDDAESRIIHPKTDD------QRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLV 173 E E R + + + + + LFK E + ++ + + Sbjct: 282 LWETRRGYEEREVLKELPHPLRLAVAMEIHGDVIEKVPLFKGAGEEFIRDIILHLEPVIY 341 Query: 174 KEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAAT 233 GE++I G+ G + Y I+RG+ ++ + D R FGE+AL+ PR AT Sbjct: 342 GPGEYIIRAGEMGSDVYFINRGSVEV-LSADEKTRY-AILSEGQFFGEMALILRAPRTAT 399 Query: 234 ITATSPGALWGLDRVTFRRII---------VKNNAKKRKMYES 267 + A + L+ LD+ TF RI+ ++ A +RK ES Sbjct: 400 VRARAFCDLYRLDKETFDRILSRYPEIAAQIQELAVRRKELES 442 >5JON-A nrPDB Length = 517 Score = 124 bits (311), Expect = 7e-29, Method: Composition-based stats. Identities = 35/157 (22%), Positives = 64/157 (40%), Gaps = 18/157 (11%) Query: 250 FRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLAD 309 R IV N +K + S+P + + + ++ + +V+ G+ II +G + Sbjct: 376 LREEIVNFNCRK------LVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGK 429 Query: 310 SFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTV 369 + ++ G V + KG E+ + G YFGE+ L+T R AS A Sbjct: 430 KMYFIQHGVVSVLT--KGNKEM---------KLSDGSYFGEICLLTRGRRTASVRADTYC 478 Query: 370 KCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFG 406 + ++ V F +L +M+R T + G Sbjct: 479 RLYSLSVDNFNEVLEEYP-MMRRAFETVAIDRLDRIG 514 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 41/229 (17%), Positives = 77/229 (33%), Gaps = 17/229 (7%) Query: 34 QHFTRLQQENERKGAARFGHEGRTWGDAGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEA 93 + + ++ A +E D AA KG P S Sbjct: 289 EGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAV 348 Query: 94 AEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLF 153 A + V + AE P EE + ++ + LF Sbjct: 349 INAASGRQTVDEALKDAQTNAAELNGPLREEIVNFN-------------CRKLVASMPLF 395 Query: 154 KNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNY 213 N DP ++ +L + ++ + G+++I +G G Y I G + K + + Sbjct: 396 ANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMK----L 451 Query: 214 DNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKR 262 + FGE+ L+ R A++ A + L+ L F ++ + +R Sbjct: 452 SDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 500 >4CHV-A nrPDB Length = 361 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 30/123 (24%), Positives = 52/123 (42%), Gaps = 13/123 (10%) Query: 267 SFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRK 326 + ++P + L + +++V + + G I G+ D F V G V + Sbjct: 228 QLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSV----- 282 Query: 327 GKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPC 386 VE G +FGE+AL++ +PR+A+ A TV L++ F+ L Sbjct: 283 -----ATPNPVE---LGPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQMLCSSS 334 Query: 387 MEI 389 EI Sbjct: 335 PEI 337 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 27/120 (22%), Positives = 52/120 (43%), Gaps = 8/120 (6%) Query: 134 PKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVID 193 + D RN + + LF+ L P + +++ A+ + V G + G+ GD + + Sbjct: 219 RRGDFVRN--WQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVV 276 Query: 194 RGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRI 253 G+ + FGE+AL+ PR+AT++A + +L L F+ + Sbjct: 277 EGSVSVATPN------PVELGPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQML 330 >5U6P-A nrPDB Length = 660 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 32/166 (19%), Positives = 63/166 (37%), Gaps = 18/166 (10%) Query: 247 RVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGD 306 R IV N +K + ++P + + + ++ + +V+ G+ II +G Sbjct: 454 NDPLREEIVNFNCRK------LVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGA 507 Query: 307 LADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAI 366 + + ++ G + K + + G YFGE+ L+T R AS A Sbjct: 508 VGKKMYFIQHGVAGVITKSSKEM-----------KLTDGSYFGEICLLTKGRRTASVRAD 556 Query: 367 GTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIV 412 + ++ V F +L +M+R T + G I+ Sbjct: 557 TYCRLYSLSVDNFNEVLEEYP-MMRRAFETVAIDRLDRIGKKNSIL 601 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 34/162 (20%), Positives = 68/162 (41%), Gaps = 5/162 (3%) Query: 144 QEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKC 203 ++ + LF N DP ++ +L + ++ + G+++I +G G Y I G + K Sbjct: 467 RKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKS 526 Query: 204 DGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRK 263 + + FGE+ L+ R A++ A + L+ L F ++ + +R Sbjct: 527 SKEMK----LTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRA 582 Query: 264 MYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGE-QIIAQ 304 I+ L + K + T V+N+ E +I+ Q Sbjct: 583 FETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQ 624 >3DKW-A nrPDB Length = 227 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 2/117 (1%) Query: 144 QEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VK 202 Q+ + LF+ L P Q+ ++L + + +G +V QG+ FY + G IY + Sbjct: 8 QQLLQSHHLFEPLSPVQLQELLASSDLVNLDKGAYVFRQGEPAHAFYYLISGCVKIYRLT 67 Query: 203 CDGVGRCVGNYDNRGSFGELALMYNTPR-AATITATSPGALWGLDRVTFRRIIVKNN 258 +G + + + R +F E + +TP AT A P L+ + R + N Sbjct: 68 PEGQEKILEVTNERNTFAEAMMFMDTPNYVATAQAVVPSQLFRFSNKAYLRQLQDNT 124 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 47/122 (38%), Gaps = 7/122 (5%) Query: 263 KMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKIT 322 ++++ ++S + L + +++ + G + QG+ A +F+ + SG VKI Sbjct: 5 RVHQQLLQSHHLFEPLSPVQLQELLASSDLVNLDKGAYVFRQGEPAHAFYYLISGCVKIY 64 Query: 323 MKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPR-AASAHAIGTVKCLAMDVQAFER 381 E + F E + + P A+A A+ + +A+ R Sbjct: 65 RLTPEGQE------KILEVTNERNTFAEAMMFMDTPNYVATAQAVVPSQLFRFSNKAYLR 118 Query: 382 LL 383 L Sbjct: 119 QL 120 >4EV0-A nrPDB Length = 216 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 28/118 (23%), Positives = 47/118 (39%), Gaps = 1/118 (0%) Query: 147 CKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VKCDG 205 K LF L PE++ L +L +G+ + QGD G Y++ G ++ G Sbjct: 1 MKGSPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGG 60 Query: 206 VGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRK 263 R + FGE++L+ R+A+ A L L R + +I + Sbjct: 61 QERTLALLGPGELFGEMSLLDEGERSASAVAVEDTELLALFREDYLALIRRLPLVAHN 118 Score = 92.9 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 30/119 (25%), Positives = 53/119 (44%), Gaps = 6/119 (5%) Query: 273 PFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVE 332 P L E + ++Y G+ I QGDL + ++V SG+V++ G E Sbjct: 5 PLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQE-- 62 Query: 333 ENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMK 391 +A G+ FGE++L+ R+ASA A+ + LA+ + + L+ + Sbjct: 63 ----RTLALLGPGELFGEMSLLDEGERSASAVAVEDTELLALFREDYLALIRRLPLVAH 117 >4ORF-A nrPDB Length = 340 Score = 85.6 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%) Query: 269 IESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGK 328 + +L F S + + G+ +I QGD A +F ++ESG V++ Sbjct: 19 LAALEFFTGCRPSALEPLATQLRPLKAEPGQVLIRQGDPALTFMLIESGRVQV------- 71 Query: 329 SEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLL 383 S +G + G GE+AL+ + P+ A+ A V D AF+ +L Sbjct: 72 SHAVADGPPIVLDIEPGLIIGEIALLRDAPKTATVVAAEPVIGWVGDRDAFDTIL 126 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 55/160 (34%), Gaps = 10/160 (6%) Query: 136 TDDQRNRLQEA----CKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYV 191 L E + F P + + + + G+ +I QGD F + Sbjct: 4 DPGNVAELTEVRAADLAALEFFTGCRPSALEPLATQLRPLKAEPGQVLIRQGDPALTFML 63 Query: 192 IDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFR 251 I+ G + V + + GE+AL+ + P+ AT+ A P W DR F Sbjct: 64 IESGRVQVSHAVADGPPIVLDIEPGLIIGEIALLRDAPKTATVVAAEPVIGWVGDRDAFD 123 Query: 252 RIIV------KNNAKKRKMYESFIESLPFLKSLEVSERLK 285 I+ + R+ +FI +P L+ Sbjct: 124 TILHLPGMFDRLVRIARQRLAAFITPIPVQVRTGEWFYLR 163 >4CYD-A nrPDB Length = 225 Score = 84.9 bits (208), Expect = 6e-17, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 45/115 (39%), Gaps = 1/115 (0%) Query: 143 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVK 202 +QE +F+ +DP ++ ++ M G + D+G+ GD Y+I G + Sbjct: 2 VQEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLARH 61 Query: 203 -CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVK 256 DG + FGEL++ PR ++ + ++ R + Sbjct: 62 APDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVAD 116 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 21/124 (16%), Positives = 45/124 (36%), Gaps = 6/124 (4%) Query: 266 ESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKR 325 + + + ++ + ++ + T + G I +G+ D +I+ SG+VK+ Sbjct: 3 QEILSRAGIFQGVDPTAVNNLIQDMETVRFPRGATIFDEGEPGDRLYIITSGKVKLAR-- 60 Query: 326 KGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGP 385 + + FGEL++ PR +SA + V M+ + Sbjct: 61 ----HAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSAVCVTEVHAATMNSDMLRNWVAD 116 Query: 386 CMEI 389 I Sbjct: 117 HPAI 120 >3I59-A nrPDB Length = 249 Score = 84.5 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 45/115 (39%), Gaps = 1/115 (0%) Query: 143 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVK 202 + E +F+ ++P ++ + + G V +G+ GD Y+I G I + Sbjct: 26 MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRR 85 Query: 203 -CDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVK 256 DG + FGEL++ PR ++ T + +DR R I Sbjct: 86 APDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIAD 140 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 28/124 (22%), Positives = 50/124 (40%), Gaps = 6/124 (4%) Query: 266 ESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKR 325 + + + +E S + + + G + A+G+ D +I+ SG+VKI + Sbjct: 27 DEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRA 86 Query: 326 KGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGP 385 E + FGEL++ PR +SA I V+ ++MD A + Sbjct: 87 PDGREN------LLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIAD 140 Query: 386 CMEI 389 EI Sbjct: 141 RPEI 144 >4AVC-A nrPDB Length = 333 Score = 81.4 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 25/111 (22%), Positives = 47/111 (42%), Gaps = 7/111 (6%) Query: 269 IESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGK 328 + + + + + + G+ ++ QG+ A SF ++ SG ++ Sbjct: 15 LAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEV------- 67 Query: 329 SEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAF 379 S V ++G IAR G GE+AL+ + PR+A+ I + AF Sbjct: 68 SHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAF 118 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 56/136 (41%), Gaps = 6/136 (4%) Query: 145 EACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 204 E + +F+ E + + ++ G+ ++ QG+ +F +I G+ ++ D Sbjct: 13 EDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGD 72 Query: 205 GVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRII------VKNN 258 + GE+AL+ ++PR+AT+T P W R F ++ + Sbjct: 73 DGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLL 132 Query: 259 AKKRKMYESFIESLPF 274 R+ +F+ +P Sbjct: 133 RTARQRLAAFVSPIPV 148 >5XBY-A nrPDB Length = 97 Score = 80.2 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 28/50 (56%), Positives = 38/50 (76%) Query: 4 EIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGH 53 +IP GLTELLQG+TVEVLR QP DL+EFA+++FTRL++ ++ F Sbjct: 5 QIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARNKEQQNAFYE 54 >5H78-A nrPDB Length = 197 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 29/60 (48%), Positives = 41/60 (68%) Query: 3 IEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAG 62 ++IP GLTELLQG+TVEVLR QP DL+EFA+++FTRL+ E + + + + D Sbjct: 4 MQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLRSERVNERVKQLAEKAKEATDKE 63 >5H77-A nrPDB Length = 90 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 33/82 (40%), Positives = 47/82 (57%) Query: 4 EIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAGA 63 +IP GLTELLQG+TVEVLR QP DL+EFA+++FTRL+Q+ + +A Sbjct: 5 QIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLRQQRAFYEILHLPNLNEEQRNAFI 64 Query: 64 AAGGGIPSKGVNFAEEPMRSDS 85 + PS+ N E + + Sbjct: 65 QSLKDDPSQSANLLAEAKKLND 86 >5H3O-A nrPDB Length = 738 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 22/135 (16%), Positives = 53/135 (39%), Gaps = 15/135 (11%) Query: 263 KMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKIT 322 +++ + + + E ++V + +V++ G+ I +GD+ +IV+ G +++ Sbjct: 487 QVHFETLRKVRIFQDCEAGLLAELVLKLQLQVFSPGDFICKKGDIGREMYIVKRGRLQV- 545 Query: 323 MKRKGKSEVEENGAVEIARCFRGQYFGELALV------TNKPRAASAHAIGTVKCLAMDV 376 V+++G G FGEL+++ R A+ ++G + Sbjct: 546 --------VDDDGKKVFVTLQEGSVFGELSILNIAGSKNGNRRTANVRSVGYTDLFVLSK 597 Query: 377 QAFERLLGPCMEIMK 391 L + K Sbjct: 598 TDLWNALREYPDARK 612 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 21/151 (13%), Positives = 57/151 (37%), Gaps = 11/151 (7%) Query: 145 EACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCD 204 E + + +F++ + +++++ + ++ G+ + +GD G Y++ RG + D Sbjct: 491 ETLRKVRIFQDCEAGLLAELVLKLQLQVFSPGDFICKKGDIGREMYIVKRGRLQVV--DD 548 Query: 205 GVGRCVGNYDNRGSFGELALM------YNTPRAATITATSPGALWGLDRVTFRRIIVKNN 258 + FGEL+++ R A + + L+ L + + + Sbjct: 549 DGKKVFVTLQEGSVFGELSILNIAGSKNGNRRTANVRSVGYTDLFVLSKTDLWNALREYP 608 Query: 259 AKKRKMY---ESFIESLPFLKSLEVSERLKV 286 ++ + ++ L E+ V Sbjct: 609 DARKLLLAKGREILKKDNLLDENAPEEQKTV 639 >4I0B-A nrPDB Length = 222 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 23/113 (20%), Positives = 46/113 (40%), Gaps = 7/113 (6%) Query: 290 IGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFG 349 Y +I QG+ A++ + + G V + +K + E+ ++ +G + G Sbjct: 31 CHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEM------ILSYLNQGDFIG 84 Query: 350 ELALVTNK-PRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 401 EL L R+A A + + + F +L+ +I+ R A +L Sbjct: 85 ELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRL 137 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 29/152 (19%), Positives = 56/152 (36%), Gaps = 15/152 (9%) Query: 173 VKEGEHVIDQGDDGDNFYVIDRGTFDIYVK-CDGVGRCVGNYDNRGSFGELALMYNTP-R 230 +I QG+ + Y I +G+ + +K +G + + GEL L R Sbjct: 36 YPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQER 95 Query: 231 AATITATSPGALWGLDRVTFRRIIVKN----------NAKKRKMYESFIESLPFLKSLE- 279 +A + A + + + FR++I N A++ ++ + +L FL Sbjct: 96 SAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGR 155 Query: 280 -VSERLKVVDVIGTKVYNDGEQI-IAQGDLAD 309 L + DG QI I + ++ Sbjct: 156 IAQTLLNLAKQPDAMTLPDGMQIKITRQEIGQ 187 >3KCC-A nrPDB Length = 260 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 23/113 (20%), Positives = 46/113 (40%), Gaps = 7/113 (6%) Query: 290 IGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFG 349 Y +I QG+ A++ + + G V + +K + E+ ++ +G + G Sbjct: 69 CHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEM------ILSYLNQGDFIG 122 Query: 350 ELALVTNK-PRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 401 EL L R+A A + + + F +L+ +I+ R A +L Sbjct: 123 ELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRL 175 Score = 64.4 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 51/148 (34%), Gaps = 5/148 (3%) Query: 110 RASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMF 169 R S E E +S + D ++ ++L K + L Sbjct: 14 RGSGMKETAAAKFERQHMDSPDL---GTDDDDKAMADIGSMVLGKPQTDPTLEWFLSHCH 70 Query: 170 EKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVK-CDGVGRCVGNYDNRGSFGELALMYNT 228 +I QG+ + Y I +G+ + +K +G + + GEL L Sbjct: 71 IHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEG 130 Query: 229 P-RAATITATSPGALWGLDRVTFRRIIV 255 R+A + A + + + FR++I Sbjct: 131 QERSAWVRAKTACEVAEISYKKFRQLIQ 158 >3E97-A nrPDB Length = 231 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 30/149 (20%), Positives = 66/149 (44%), Gaps = 14/149 (9%) Query: 269 IESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGK 328 ++ P +++ + + V+ + + E ++ Q ++ +V +G V+++ G Sbjct: 8 LKRSPLFQNVPEDAMREALKVVTERNFQPDELVVEQDAEGEALHLVTTGVVRVSRVSLGG 67 Query: 329 SEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFE-------R 381 E G GE A++ ++ R+AS A+ V+ L + + FE R Sbjct: 68 RERVLGD-----IYAPG-VVGETAVLAHQERSASVRALTPVRTLMLHREHFELILRRHPR 121 Query: 382 LLGPCMEIMKRNIATYEEQLVALFGTNMD 410 +L E++ R + ++L+A FG N + Sbjct: 122 VLWNLAEMLARRVTFLNDELIA-FGQNTE 149 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 31/132 (23%), Positives = 60/132 (45%), Gaps = 1/132 (0%) Query: 147 CKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VKCDG 205 K LF+N+ + M + L + E+ + E V++Q +G+ +++ G + V G Sbjct: 8 LKRSPLFQNVPEDAMREALKVVTERNFQPDELVVEQDAEGEALHLVTTGVVRVSRVSLGG 67 Query: 206 VGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMY 265 R +G+ G GE A++ + R+A++ A +P L R F I+ ++ + Sbjct: 68 RERVLGDIYAPGVVGETAVLAHQERSASVRALTPVRTLMLHREHFELILRRHPRVLWNLA 127 Query: 266 ESFIESLPFLKS 277 E + FL Sbjct: 128 EMLARRVTFLND 139 >5W5B-A nrPDB Length = 236 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 53/125 (42%), Gaps = 7/125 (5%) Query: 278 LEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAV 337 L + + + + K + G + AD +IV G +++ + + + V Sbjct: 37 LHRDDVSALAETLQVKEFAPGAVVFHADQTADGVWIVRHGLIELAVGSRRRRAV------ 90 Query: 338 EIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATY 397 + G G++ L+ P + A+ CL +D QAFERLL I +R +++ Sbjct: 91 -VNILHPGDVDGDIPLLLEMPMVYTGRALTQATCLFLDRQAFERLLATHPAIARRWLSSV 149 Query: 398 EEQLV 402 +++ Sbjct: 150 AQRVS 154 >5VA1-A nrPDB Length = 795 Score = 62.9 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 17/127 (13%), Positives = 39/127 (30%), Gaps = 13/127 (10%) Query: 264 MYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITM 323 + S ++ + + T G+ ++ GDL + + + G ++I Sbjct: 492 LNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILR 551 Query: 324 KRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAAS--AHAIGTVKCLAMDVQAFER 381 V +A + FGE + +P ++ A+ + Sbjct: 552 GD-----------VVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLE 600 Query: 382 LLGPCME 388 +L E Sbjct: 601 VLDMYPE 607 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 35/113 (30%), Gaps = 6/113 (5%) Query: 144 QEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKC 203 + + F+ + + G+ ++ GD Y I RG+ +I Sbjct: 494 RSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG- 552 Query: 204 DGVGRCVGNYDNRGSFGELALMYNTPRAAT--ITATSPGALWGLDRVTFRRII 254 V FGE +Y P + + A + L + R ++ Sbjct: 553 ---DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 602 >2N7G-A nrPDB Length = 154 Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 17/135 (12%), Positives = 39/135 (28%), Gaps = 13/135 (9%) Query: 256 KNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVE 315 + S ++ + + T G+ ++ GDL + + + Sbjct: 14 GTENLYFQSMRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFIS 73 Query: 316 SGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAAS--AHAIGTVKCLA 373 G ++I V +A + FGE + +P ++ A+ Sbjct: 74 RGSIEILRGD-----------VVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHK 122 Query: 374 MDVQAFERLLGPCME 388 + +L E Sbjct: 123 IHRDDLLEVLDMYPE 137 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 36/114 (31%), Gaps = 6/114 (5%) Query: 143 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVK 202 ++ + F+ + + G+ ++ GD Y I RG+ +I Sbjct: 23 MRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 82 Query: 203 CDGVGRCVGNYDNRGSFGELALMYNTPRAAT--ITATSPGALWGLDRVTFRRII 254 V FGE +Y P + + A + L + R ++ Sbjct: 83 ----DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 132 >2OZ6-A nrPDB Length = 207 Score = 62.1 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 41/110 (37%), Gaps = 10/110 (9%) Query: 285 KVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFR 344 K++ + Y II GD ++ F + G V I ++ E+ I Sbjct: 8 KLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREM------IIGYLNS 61 Query: 345 GQYFGELALV----TNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIM 390 G +FGEL L + + R+A A + + F L EI+ Sbjct: 62 GDFFGELGLFEKEGSEQERSAWVRAKVECEVAEISYAKFRELSQQDSEIL 111 Score = 61.4 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 41/103 (39%), Gaps = 5/103 (4%) Query: 159 EQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVK-CDGVGRCVGNYDNRG 217 + + ++L + +I GD + + I +G+ I ++ DG +G ++ Sbjct: 4 KHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGD 63 Query: 218 SFGELALM----YNTPRAATITATSPGALWGLDRVTFRRIIVK 256 FGEL L R+A + A + + FR + + Sbjct: 64 FFGELGLFEKEGSEQERSAWVRAKVECEVAEISYAKFRELSQQ 106 >3H3Z-A nrPDB Length = 235 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 21/118 (17%), Positives = 46/118 (38%), Gaps = 1/118 (0%) Query: 140 RNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDI 199 + ++ LL ++L + + +L + GE + Q + +V+ G + Sbjct: 4 HEAQKAIARNSLLIRSLPEQHVDALLSQAVWRSYDRGETLFLQEEKAQAIHVVIDGWVKL 63 Query: 200 Y-VKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVK 256 + + G V + SFGE + NTP + A +P + + F ++ + Sbjct: 64 FRMTPTGSEAVVSVFTRGESFGEAVALRNTPYPVSAEAVTPCEVMHIPSPVFVSLMRR 121 Score = 56.4 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 27/116 (23%), Positives = 47/116 (40%), Gaps = 6/116 (5%) Query: 274 FLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEE 333 ++SL ++ + Y+ GE + Q + A + +V G VK+ SE Sbjct: 16 LIRSLPEQHVDALLSQAVWRSYDRGETLFLQEEKAQAIHVVIDGWVKLFRMTPTGSE--- 72 Query: 334 NGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEI 389 ++ RG+ FGE + N P SA A+ + + + F L+ EI Sbjct: 73 ---AVVSVFTRGESFGEAVALRNTPYPVSAEAVTPCEVMHIPSPVFVSLMRRDPEI 125 >3UKN-A nrPDB Length = 212 Score = 59.4 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 23/136 (16%), Positives = 48/136 (35%), Gaps = 13/136 (9%) Query: 269 IESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGK 328 + LP +S + +I T GE +I QGD + + V SG +++ Sbjct: 77 LLQLPLFESASRGCLRSLSLIIKTSFCAPGEFLIRQGDALQAIYFVCSGSMEVLKDN--- 133 Query: 329 SEVEENGAVEIARCFRGQYFGELALVTNKP--RAASAHAIGTVKCLAMDVQAFERLLGPC 386 +A +G G +L + A+ A+ + ++ +L Sbjct: 134 --------TVLAILGKGDLIGSDSLTKEQVIKTNANVKALTYCDLQYISLKGLREVLRLY 185 Query: 387 MEIMKRNIATYEEQLV 402 E ++ ++ + L Sbjct: 186 PEYAQKFVSEIQHDLT 201 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 17/115 (14%), Positives = 36/115 (31%), Gaps = 6/115 (5%) Query: 143 LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVK 202 L + + LF++ + + + GE +I QGD Y + G+ ++ Sbjct: 73 LNKELLQLPLFESASRGCLRSLSLIIKTSFCAPGEFLIRQGDALQAIYFVCSGSMEVLK- 131 Query: 203 CDGVGRCVGNYDNRGSFGELALMYNTP--RAATITATSPGALWGLDRVTFRRIIV 255 + G +L A + A + L + R ++ Sbjct: 132 ---DNTVLAILGKGDLIGSDSLTKEQVIKTNANVKALTYCDLQYISLKGLREVLR 183 >5K7L-A nrPDB Length = 857 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 17/131 (12%), Positives = 39/131 (29%), Gaps = 12/131 (9%) Query: 144 QEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKC 203 ++ K+ F+ + + G+ + G+ D+ + G+ ++ Sbjct: 546 RKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQ-- 603 Query: 204 DGVGRCVGNYDNRGSFG-----ELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNN 258 V FG E L A + A + L + R ++++ Sbjct: 604 --DDEVVAILGKGDVFGDVFWKEATL---AQSCANVRALTYCDLHVIKRDALQKVLEFYT 658 Query: 259 AKKRKMYESFI 269 A + I Sbjct: 659 AFSHSFSRNLI 669 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 48/150 (32%), Gaps = 21/150 (14%) Query: 264 MYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITM 323 + + P + + T G+ I G+ DS V SG +++ Sbjct: 544 LNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQ 603 Query: 324 KRKGKSEVEENGAVEIARCFRGQYFGEL----ALVTNKPRAASAHAIGTVKCLAMDVQAF 379 + +A +G FG++ A + A+ A+ + A Sbjct: 604 DDEV-----------VAILGKGDVFGDVFWKEATLAQS--CANVRALTYCDLHVIKRDAL 650 Query: 380 ERLL---GPCMEIMKRN-IATYEEQLVALF 405 +++L RN I TY + +F Sbjct: 651 QKVLEFYTAFSHSFSRNLILTYNLRKRIVF 680 >4F8A-A nrPDB Length = 160 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 17/131 (12%), Positives = 39/131 (29%), Gaps = 12/131 (9%) Query: 144 QEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKC 203 ++ K+ F+ + + G+ + G+ D+ + G+ ++ Sbjct: 26 RKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQ-- 83 Query: 204 DGVGRCVGNYDNRGSFG-----ELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNN 258 V FG E L A + A + L + R ++++ Sbjct: 84 --DDEVVAILGKGDVFGDVFWKEATL---AQSCANVRALTYCDLHVIKRDALQKVLEFYT 138 Query: 259 AKKRKMYESFI 269 A + I Sbjct: 139 AFSHSFSRNLI 149 Score = 51.3 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 48/150 (32%), Gaps = 21/150 (14%) Query: 264 MYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITM 323 + + P + + T G+ I G+ DS V SG +++ Sbjct: 24 LNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQ 83 Query: 324 KRKGKSEVEENGAVEIARCFRGQYFGEL----ALVTNKPRAASAHAIGTVKCLAMDVQAF 379 + +A +G FG++ A + A+ A+ + A Sbjct: 84 DDEV-----------VAILGKGDVFGDVFWKEATLAQS--CANVRALTYCDLHVIKRDAL 130 Query: 380 ERLL---GPCMEIMKRN-IATYEEQLVALF 405 +++L RN I TY + +F Sbjct: 131 QKVLEFYTAFSHSFSRNLILTYNLRKRIVF 160 >3IWZ-A nrPDB Length = 230 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 16/103 (15%), Positives = 32/103 (31%), Gaps = 2/103 (1%) Query: 155 NLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGV-GRCVGNY 213 LD + + L + V GD Y + G+ I + D +G + Sbjct: 21 TLDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYF 80 Query: 214 DNRGSFGELALMYN-TPRAATITATSPGALWGLDRVTFRRIIV 255 + GE+ L R + + L + +++ Sbjct: 81 GSGEFVGEMGLFIESDTREVILRTRTQCELAEISYERLQQLFQ 123 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 36/91 (39%), Gaps = 7/91 (7%) Query: 293 KVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELA 352 + Y + GD A + + V SG V I +E +++ + + G++ GE+ Sbjct: 37 RRYPTRTDVFRPGDPAGTLYYVISGSVSII------AEEDDDRELVLGYFGSGEFVGEMG 90 Query: 353 L-VTNKPRAASAHAIGTVKCLAMDVQAFERL 382 L + + R + + + ++L Sbjct: 91 LFIESDTREVILRTRTQCELAEISYERLQQL 121 >4L11-A nrPDB Length = 204 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 47/132 (35%), Gaps = 10/132 (7%) Query: 153 FKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGN 212 F+ P + + G+ ++ +GD Y I RG+ +I + Sbjct: 80 FEAASPGCLRALSLKFKTTHAPPGDILVHKGDVLTYLYFIARGSIEILK----DDVVMAI 135 Query: 213 YDNRGSFGELALMYNT--PRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIE 270 FGE +++T + + A + L + R ++ + Y+SF+ Sbjct: 136 LGKDDIFGENPCIHSTLGKSNSNVKALTYCDLHKIHRDDLLDVLDLFP----EFYDSFVN 191 Query: 271 SLPFLKSLEVSE 282 SL ++ E Sbjct: 192 SLEITYNMRDEE 203 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 12/106 (11%), Positives = 32/106 (30%), Gaps = 13/106 (12%) Query: 273 PFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVE 332 ++ + T G+ ++ +GD+ + + G ++I Sbjct: 78 SAFEAASPGCLRALSLKFKTTHAPPGDILVHKGDVLTYLYFIARGSIEILKDD------- 130 Query: 333 ENGAVEIARCFRGQYFGELALVTN--KPRAASAHAIGTVKCLAMDV 376 V +A + FGE + + ++ A+ + Sbjct: 131 ----VVMAILGKDDIFGENPCIHSTLGKSNSNVKALTYCDLHKIHR 172 >2D93-A nrPDB Length = 134 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 27/120 (22%), Positives = 47/120 (39%), Gaps = 14/120 (11%) Query: 141 NRLQEACKDILLFKNLDPEQMSQVLDAM-FEKLVKEGEHVIDQGDDGDNFYVIDRGTFDI 199 +L E + F N+ ++ M FE + + G +++ G + D++YVI GT +I Sbjct: 12 EQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEI 71 Query: 200 YVKCDGVGRCVGNYDNRGSFG-----ELALMYNTPRAATITATSPGALWGLDRVTFRRII 254 DG V N SFG + M+ R + + + RI+ Sbjct: 72 S-HPDGK---VENLFMGNSFGITPTLDKQYMHGIVRT----KVDDCQFVCIAQQDYWRIL 123 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 49/128 (38%), Gaps = 13/128 (10%) Query: 262 RKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYND-GEQIIAQGDLADSFFIVESGEVK 320 + F+ LP ++ +S R ++ V+ +V G I+ G DS++++ +G V+ Sbjct: 11 IEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVE 70 Query: 321 ITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHA-IGTVKCLAMDVQAF 379 I + ++ F G FG + + + + + + Q + Sbjct: 71 I-----------SHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDY 119 Query: 380 ERLLGPCM 387 R+L Sbjct: 120 WRILNHVE 127 >3B02-A nrPDB Length = 195 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 11/113 (9%) Query: 293 KVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELA 352 K + E I +G+ A + + +E G V++ + + + + G YFGE A Sbjct: 2 KRFARKETIYLRGEEARTLYRLEEGLVRVV------ELLPDGRLITLRHVLPGDYFGEEA 55 Query: 353 LVTNKPR-AASAHAIGTVKCL---AMDVQAFERLLGPCMEIMKRNIATYEEQL 401 L R A A V+ L AMD +A R+ M+R + YE L Sbjct: 56 LEGKAYRYTAEAMTEAVVQGLEPRAMDHEALHRVARNLARQMRR-VQAYEAHL 107 Score = 37.9 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 38/108 (35%), Gaps = 7/108 (6%) Query: 171 KLVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VKCDGVGRCVGNYDNRGSFGELALMYNTP 229 K E + +G++ Y ++ G + + DG + + FGE AL Sbjct: 2 KRFARKETIYLRGEEARTLYRLEEGLVRVVELLPDGRLITLRHVLPGDYFGEEALEGKAY 61 Query: 230 R-AATITATSPGALW---GLDRVTFRRIIVKNN--AKKRKMYESFIES 271 R A + +D R+ ++ + YE+ +++ Sbjct: 62 RYTAEAMTEAVVQGLEPRAMDHEALHRVARNLARQMRRVQAYEAHLQT 109 >2XKO-A nrPDB Length = 222 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 32/81 (39%), Gaps = 3/81 (3%) Query: 168 MFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VKCDGVGRCVGNYDNRGSFGELALMY 226 + + + G+ + GD + Y++ +G + V G V FG L+L+ Sbjct: 22 LQIEQFERGKTIFFPGDPAERVYLLVKGAVKLSRVYESGEEITVALLRENSVFGVLSLLT 81 Query: 227 N--TPRAATITATSPGALWGL 245 + R A +P L+ + Sbjct: 82 GQRSDRFYHAVAFTPVQLFSV 102 >3LA7-A nrPDB Length = 243 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 26/121 (21%), Positives = 49/121 (40%), Gaps = 11/121 (9%) Query: 292 TKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGEL 351 + + + I GD A+ + + G VK++ + E + +A FG L Sbjct: 45 VETFERNKTIFFPGDPAERVYFLLKGAVKLSRVYEAGEE------ITVALLRENSVFGVL 98 Query: 352 ALVTNKP--RAASAHAIGTVKCLAMDVQAFERLLGPCME---IMKRNIATYEEQLVALFG 406 +L+T R A A V+ L+ ++ E+ L E +M R +++ Q + Sbjct: 99 SLLTGNKSDRFYHAVAFTPVELLSAPIEQVEQALKENPELSMLMLRGLSSRILQTEMMIE 158 Query: 407 T 407 T Sbjct: 159 T 159 Score = 44.4 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 29/96 (30%), Gaps = 5/96 (5%) Query: 154 KNLDPEQMSQVLDAMFEK--LVKEGEHVIDQGDDGDNFYVIDRGTFDIY-VKCDGVGRCV 210 K L A + + + GD + Y + +G + V G V Sbjct: 27 KALANVFRQMATGAFPPVVETFERNKTIFFPGDPAERVYFLLKGAVKLSRVYEAGEEITV 86 Query: 211 GNYDNRGSFGELALM--YNTPRAATITATSPGALWG 244 FG L+L+ + R A +P L Sbjct: 87 ALLRENSVFGVLSLLTGNKSDRFYHAVAFTPVELLS 122 >1ZYB-A nrPDB Length = 232 Score = 45.2 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 24/141 (17%), Positives = 43/141 (30%), Gaps = 19/141 (13%) Query: 140 RNRLQEACKDILLFKNLDPEQMSQVLDA--MFEKLVKEGEHVIDQGDDGDNFYVIDRGTF 197 + + + LF+ L E + +LD + K GE +I G+ + +G Sbjct: 13 METMFDTLLQLPLFQGLCHEDFTSILDKVKLHFIKHKAGETIIKSGNPCTQLCFLLKGEI 72 Query: 198 DIYVKCDGVGRCVGN-------YDNRGSFGELALMYNTPRAATITATSPGALWGLDR--- 247 I V + + FG NT A++ A + + + Sbjct: 73 SIVTNAKENIYTVIEQIEAPYLIEPQSLFG-----MNTNYASSYVAHTEVHTVCISKAFV 127 Query: 248 --VTFRRIIVKNNAKKRKMYE 266 FR I + N Sbjct: 128 LSDLFRYDIFRLNYMNIVSNR 148 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 38/116 (32%), Gaps = 8/116 (6%) Query: 263 KMYESFIESLPFLKSLEVSERLKVVDVIG--TKVYNDGEQIIAQGDLADSFFIVESGEVK 320 M+++ ++ LP + L + ++D + + GE II G+ + GE+ Sbjct: 15 TMFDTLLQ-LPLFQGLCHEDFTSILDKVKLHFIKHKAGETIIKSGNPCTQLCFLLKGEIS 73 Query: 321 ITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAASAHAIGTVKCLAMDV 376 I K FG N A+S A V + + Sbjct: 74 IVTNAKENIYTVIEQIEAPYLIEPQSLFG-----MNTNYASSYVAHTEVHTVCISK 124 >2GAU-A nrPDB Length = 232 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 48/150 (32%), Gaps = 17/150 (11%) Query: 168 MFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKC-DGVGRCVGNYDNRGSFGELALMY 226 + K+ V +GD +N + + G I + G FG Sbjct: 33 IQPFPCKKASTVFSEGDIPNNLFYLYEGKIKILREGVYGRFHISRIVKPGQFFGMRPYFA 92 Query: 227 NTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKV 286 ++T A + + ++ N F+++L K L +ER V Sbjct: 93 EETCSSTAIAVENSKVLAIPVEAIEALLKGNT----SFCRYFLKALA--KELGYAERRTV 146 Query: 287 VDVIGTKVYNDGEQIIAQGDLADSFFIVES 316 + K +G LA++ I++ Sbjct: 147 T--LTQKHV--------RGRLAETLLILKE 166 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 20/88 (22%), Positives = 38/88 (43%), Gaps = 6/88 (6%) Query: 296 NDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVT 355 + ++GD+ ++ F + G++KI + GQ+FG Sbjct: 39 KKASTVFSEGDIPNNLFYLYEGKIKILREGVYGRFHIS------RIVKPGQFFGMRPYFA 92 Query: 356 NKPRAASAHAIGTVKCLAMDVQAFERLL 383 + +++A A+ K LA+ V+A E LL Sbjct: 93 EETCSSTAIAVENSKVLAIPVEAIEALL 120 >2FMY-A nrPDB Length = 220 Score = 42.9 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 21/118 (17%), Positives = 41/118 (34%), Gaps = 7/118 (5%) Query: 147 CKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGV 206 D L + L+ E+ S VL E+ + + + + +++ G +Y+ + Sbjct: 6 LTDTNLLEVLNSEEYSGVLKEFREQRYSKKAILYTPNTERNLVFLVKSGRVRVYLAYEDK 65 Query: 207 GRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKM 264 + + F T A I A + D F+ I+V+ A M Sbjct: 66 EFTLAILEAGDIFC-------THTRAFIQAMEDTTILYTDIRNFQNIVVEFPAFSLNM 116 >1O5L-A nrPDB Length = 213 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 17/116 (14%), Positives = 44/116 (37%), Gaps = 6/116 (5%) Query: 160 QMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDI-YVKCDGVGRCVGNYDNRGS 218 + ++L + ++GE V Q D ++ ++ GT +V +G + Sbjct: 14 DLKKLLPCGKVIVFRKGEIVKHQDDPIEDVLILLEGTLKTEHVSENGKTLEIDEIKPVQI 73 Query: 219 FGELALMYNTPR-AATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLP 273 + + PR + A + + + F +++ K R++ F++ + Sbjct: 74 IASGFIFSSEPRFPVNVVAGENSKILSIPKEVFLDLLM----KDRELLLFFLKDVS 125 Score = 38.3 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 21/107 (19%), Positives = 41/107 (38%), Gaps = 7/107 (6%) Query: 285 KVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFR 344 K++ V+ GE + Q D + I+ G +K + +E + + Sbjct: 17 KLLPCGKVIVFRKGEIVKHQDDPIEDVLILLEGTLKTEHVSENGKTLEIDEIKPVQIIAS 76 Query: 345 GQYFGELALVTNKPR-AASAHAIGTVKCLAMDVQAFERLLGPCMEIM 390 G F +++PR + A K L++ + F LL E++ Sbjct: 77 GFIF------SSEPRFPVNVVAGENSKILSIPKEVFLDLLMKDRELL 117 >2ZCW-A nrPDB Length = 202 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 18/77 (23%), Positives = 26/77 (33%), Gaps = 4/77 (5%) Query: 169 FEKLVKEGEHVIDQGDDG--DNFYVIDRGTFDI-YVKCDGVGRCVGNYDNRGSFGELALM 225 K G+ ++ G G D Y + G + V +G + G FGE AL Sbjct: 6 ETVSFKAGDVILYPGVPGPRDRAYRVLEGLVRLEAVDEEGNALTLRLVRPGGFFGEEALF 65 Query: 226 YNTPRAATITATSPGAL 242 R A + L Sbjct: 66 -GQERIYFAEAATDVRL 81 >1ATT-A nrPDB Length = 429 Score = 36.7 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 57/159 (35%), Gaps = 22/159 (13%) Query: 105 NRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQV 164 RR + + + DD +I PK + ++++ +L + LD + + Sbjct: 254 KFRYRRVAESTQVLELPFKGDDITMVLILPKLEKTLAKVEQELTPDMLQEWLDELTETLL 313 Query: 165 LDAMFEKLVKEGEHVIDQ-GDDG-DNFY---------VIDRGTFDIYVKCDGVGRCVGNY 213 + M +++ V +Q D G ++ + ++ G D+YV + Sbjct: 314 VVHMPRFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVN 373 Query: 214 DNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRR 252 + E A A+ + G DRVTF+ Sbjct: 374 EEGS---EAA--------ASTVISIAGRSLNSDRVTFKA 401 >4EB1-I nrPDB Length = 440 Score = 36.3 bits (82), Expect = 0.027, Method: Composition-based stats. Identities = 32/181 (17%), Positives = 62/181 (34%), Gaps = 31/181 (17%) Query: 105 NRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQV 164 RR + + + DD +I PK + ++++ +L + LD + + Sbjct: 265 KFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMML 324 Query: 165 LDAMFEKLVKEGEHVIDQ-GDDG--DNFY--------VIDRGTFDIYVKCDGVGRCVGNY 213 + M +++G + +Q D G D F ++ G D+YV + Sbjct: 325 VVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVN 384 Query: 214 DNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLP 273 + E A A+ G +RVTF+ + + FI +P Sbjct: 385 EEGS---EAA--------ASTAVVIAGRSLNPNRVTFKA---------NRPFLVFIREVP 424 Query: 274 F 274 Sbjct: 425 L 425 >5E44-A nrPDB Length = 259 Score = 35.9 bits (81), Expect = 0.028, Method: Composition-based stats. Identities = 13/68 (19%), Positives = 27/68 (39%), Gaps = 2/68 (2%) Query: 155 NLDPEQMSQVLDAMFEKL-VKEGEHVIDQGDDGDNFYVIDRGTFDIYV-KCDGVGRCVGN 212 L+ ++ Q+ + + K +++G+ + GD+ Y I GT Y G + Sbjct: 42 TLNDSELDQLDEIIERKKPIQKGQELFKAGDELKCLYAIRSGTIKSYTITEQGDEQITAF 101 Query: 213 YDNRGSFG 220 + G Sbjct: 102 HLAGDLVG 109 >3E6B-A nrPDB Length = 250 Score = 34.4 bits (77), Expect = 0.089, Method: Composition-based stats. Identities = 16/108 (14%), Positives = 39/108 (36%), Gaps = 6/108 (5%) Query: 171 KLVKEGEHVIDQGDDGDNFYVIDRGTFDI-YVKCDGVGRCVGNYDNRGSFGELALMYNTP 229 + +G VI G++ + + G + + DG + + G+L Y T Sbjct: 35 RDFAKGSAVIMPGEEITSMIFLVEGKIKLDIIFEDGSEKLLYYAGGNSLIGKL---YPTG 91 Query: 230 RAATITATSPG-ALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLK 276 TA P W + R + + +++++++ + + Sbjct: 92 NNIYATAMEPTRTCW-FSEKSLRTVFRTDEDMIFEIFKNYLTKVAYYA 138 >4FHA-A nrPDB Length = 311 Score = 33.2 bits (74), Expect = 0.21, Method: Composition-based stats. Identities = 18/112 (16%), Positives = 41/112 (36%), Gaps = 9/112 (8%) Query: 99 FNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDP 158 +N P + A+A + + R++ T + RL + + Sbjct: 114 YNKPSQEGMYQHFKAIADASDLPIIIYNIPGRVVVELTPETMLRLAD------HPNIIGV 167 Query: 159 EQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVID---RGTFDIYVKCDGVG 207 ++ + + + + K E +I G+DGD F+ ++ G + +G Sbjct: 168 KECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGDE 219 >1Z5V-A nrPDB Length = 474 Score = 32.1 bits (71), Expect = 0.50, Method: Composition-based stats. Identities = 24/152 (15%), Positives = 51/152 (33%), Gaps = 19/152 (12%) Query: 276 KSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADS--FFI----VESGEVKITMKRKGKS 329 +S+ + V+DV+ ++ +++ G + +I + GEV T K Sbjct: 280 QSVASVRKTTVLDVMR-RLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQ 338 Query: 330 EVEENGAVEIARCFRGQYFGELALVTNKP------RAASAHAIGTVKCLAMDVQAFERLL 383 + E ++AL P R + ++ FER Sbjct: 339 RIRERKLANFIPWGPASI--QVALSRKSPYLPSAHRVSGLMMANHTSISSL----FERTC 392 Query: 384 GPCMEIMKRNIATYEEQLVALFGTNMDIVEPT 415 ++ KR + + +F N D ++ + Sbjct: 393 RQYDKLRKREAFLEQFRKEDMFKDNFDEMDTS 424 >1XKW-A nrPDB Length = 665 Score = 32.1 bits (71), Expect = 0.52, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 28/89 (31%), Gaps = 3/89 (3%) Query: 33 LQHFTRLQQENERKGAARFGHEGRTWGDAGAAAGGGIPSKGVNFAEEPMRSDSENGEEEE 92 + + Q + +R+ G + +N + R D EN +E+ Sbjct: 440 VSYAEVYQPQADRQTWNSEPLSPVEGKTYETGIKGELADGRLNLSLAAFRIDLENNPQED 499 Query: 93 AAEAGAFNAPVINRFTRRASVCAEAYNPD 121 G N P + V ++ + + Sbjct: 500 PDHPGPPNNPF---YISGGKVRSQGFELE 525 >6CXO-A nrPDB Length = 529 Score = 29.4 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 21/121 (17%), Positives = 42/121 (34%), Gaps = 4/121 (3%) Query: 201 VKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGAL-WGLDRVTFRRIIVKNNA 259 D V +Y+ FG L Y T + + + + + LD+ + + V N Sbjct: 297 TFLDDVKALPTSYEKGEYFGFLE-TYGTHYSTSGSLGGQYEIVYVLDKASMKEKGVDLND 355 Query: 260 KKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQ--IIAQGDLADSFFIVESG 317 K + + +P L+ + V+ G ++G+ I + D + G Sbjct: 356 VKHCLGFNMDLRIPLQDDLKDASVTASVNADGCIKTDNGKTVDITRDNIIDDVISFIRGG 415 Query: 318 E 318 Sbjct: 416 T 416 >5MMI-U nrPDB Length = 198 Score = 29.0 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 22/181 (12%), Positives = 52/181 (28%), Gaps = 9/181 (4%) Query: 48 AARFGHEGRTWGDAGAAAGGGIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRF 107 ++ F + + + IP+K + + N P Sbjct: 12 SSSFAFSNPSSNVSATSFTFQIPNKKAQISCISSKKLHTQKSFNFHDAVTPMNKPSF-GR 70 Query: 108 TRRASVCAEAYNPDEEEDDAESRIIHPKT-----DDQRNRLQEACKDILLFKNLDPEQMS 162 + EA P EE K + + + + + + ++ Sbjct: 71 DLMVAQATEAVAPTTEEAATSQPKTSKKAKKLKYPRRILDVYQILQS-PIITEAAIKNIA 129 Query: 163 QVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGEL 222 +F V+ + +I + NF+ + + ++ DG + + + EL Sbjct: 130 DENSLLFTVDVRADKKMIR--EAISNFFGVKVRKVNTLIRPDGTKKAYIMLNKEYNASEL 187 Query: 223 A 223 A Sbjct: 188 A 188 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.304 0.122 0.293 Lambda K H 0.267 0.0376 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,393,741 Number of Sequences: 36641 Number of extensions: 491681 Number of successful extensions: 1838 Number of sequences better than 10.0: 70 Number of HSP's better than 10.0 without gapping: 97 Number of HSP's successfully gapped in prelim test: 25 Number of HSP's that attempted gapping in prelim test: 1416 Number of HSP's gapped (non-prelim): 210 length of query: 416 length of database: 10,336,785 effective HSP length: 100 effective length of query: 316 effective length of database: 6,672,685 effective search space: 2108568460 effective search space used: 2108568460 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 60 (27.8 bits)