BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P30838 (453 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3SZA-A nrPDB 941 0.0 1AD3-A nrPDB 790 0.0 4QGK-A nrPDB 659 0.0 5NNO-A nrPDB 398 e-111 5UCD-A nrPDB 310 1e-84 6QAO-A nrPDB 164 6e-41 5FHZ-A nrPDB 160 1e-39 3TY7-A nrPDB 159 2e-39 4V3F-A nrPDB 158 5e-39 2HG2-A nrPDB 156 2e-38 4CAZ-A nrPDB 156 2e-38 5GT6-A nrPDB 155 3e-38 5AC0-A nrPDB 155 3e-38 5AC2-A nrPDB 154 6e-38 5EUY-A nrPDB 154 7e-38 3K2W-A nrPDB 154 8e-38 3RJL-A nrPDB 152 3e-37 3QAN-A nrPDB 152 3e-37 3RHD-A nrPDB 150 8e-37 1O9J-A nrPDB 150 8e-37 3I44-A nrPDB 150 1e-36 4I8Q-A nrPDB 150 1e-36 3U4J-A nrPDB 150 1e-36 4O5H-A nrPDB 149 2e-36 4GO4-A nrPDB 149 2e-36 4I8P-A nrPDB 149 3e-36 4PXL-B nrPDB 148 4e-36 3IWK-A nrPDB 148 4e-36 4LIH-A nrPDB 148 5e-36 3B4W-A nrPDB 147 7e-36 1AG8-A nrPDB 147 1e-35 4X2Q-A nrPDB 147 1e-35 4PZ2-A nrPDB 146 2e-35 5L13-A nrPDB 146 2e-35 1BPW-A nrPDB 144 6e-35 5J77-A nrPDB 143 2e-34 4YWE-A nrPDB 141 6e-34 4MPY-A nrPDB 140 1e-33 3IWJ-A nrPDB 139 3e-33 4O6R-A nrPDB 138 6e-33 3VZ3-A nrPDB 137 7e-33 4H7N-A nrPDB 137 1e-32 3JZ4-A nrPDB 136 2e-32 2D4E-A nrPDB 136 2e-32 6FK3-A nrPDB 136 2e-32 6C43-A nrPDB 136 2e-32 3R31-A nrPDB 135 3e-32 4V6H-A nrPDB 135 5e-32 6MVR-A nrPDB 134 6e-32 5UR2-A nrPDB 134 1e-31 5X5U-A nrPDB 133 2e-31 2J5N-A nrPDB 133 2e-31 6B4R-B nrPDB 131 7e-31 5KLK-A nrPDB 131 7e-31 4DNG-A nrPDB 131 7e-31 4QYJ-A nrPDB 130 1e-30 4F3X-A nrPDB 129 4e-30 3PRL-A nrPDB 128 5e-30 5VBF-A nrPDB 127 1e-29 2QE0-A nrPDB 125 5e-29 3VZ0-A nrPDB 125 5e-29 5KF0-A nrPDB 123 1e-28 3RH9-A nrPDB 123 2e-28 4U3W-A nrPDB 122 3e-28 3JU8-A nrPDB 122 3e-28 5IUV-A nrPDB 122 3e-28 4JZ6-A nrPDB 122 3e-28 1WNB-A nrPDB 122 3e-28 3RHO-A nrPDB 122 4e-28 4I3V-A nrPDB 122 5e-28 3EFV-A nrPDB 121 8e-28 5U0M-A nrPDB 120 1e-27 3EK1-A nrPDB 119 3e-27 5JRY-A nrPDB 118 4e-27 5J6B-A nrPDB 117 8e-27 1UXV-A nrPDB 117 9e-27 5TJR-A nrPDB 116 2e-26 2W8P-A nrPDB 115 3e-26 3R64-A nrPDB 113 1e-25 1T90-A nrPDB 112 3e-25 4OGD-A nrPDB 112 5e-25 3ROS-A nrPDB 110 1e-24 5N5S-A nrPDB 109 2e-24 2JG7-A nrPDB 108 5e-24 4ZZ7-A nrPDB 106 3e-23 4PXN-A nrPDB 103 2e-22 4KNA-A nrPDB 100 1e-21 4X0T-A nrPDB 97 1e-20 4E4G-A nrPDB 93 2e-19 3V9H-A nrPDB 78 7e-15 6DBB-A nrPDB 76 3e-14 4OE4-A nrPDB 74 1e-13 4LGZ-A nrPDB 74 1e-13 5UJU-A nrPDB 65 6e-11 5JFN-A nrPDB 58 9e-09 4IDS-A nrPDB 53 3e-07 1O20-A nrPDB 44 1e-04 3V4C-A nrPDB 43 2e-04 5DBV-A nrPDB 40 0.002 3K9D-A nrPDB 40 0.002 2Y53-A nrPDB 40 0.002 6D97-A nrPDB 37 0.015 3EDP-A nrPDB 33 0.29 6GB2-BC nrPDB 33 0.29 3MY7-A nrPDB 32 0.53 1VJT-A nrPDB 32 0.79 3L5K-A nrPDB 29 3.3 5SWI-B nrPDB 29 4.9 2DMU-A nrPDB 28 6.1 3IZY-P nrPDB 28 7.3 1QP8-A nrPDB 28 7.3 >3SZA-A nrPDB Length = 469 Score = 941 bits (2432), Expect = 0.0, Method: Compositional matrix adjust. Identities = 452/453 (99%), Positives = 453/453 (100%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY Sbjct: 17 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 76 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL Sbjct: 77 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 136 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180 TIQPMVGAIAAGN+VVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER Sbjct: 137 TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 196 Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS Sbjct: 197 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 256 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG Sbjct: 257 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 316 Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK Sbjct: 317 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 376 Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE Sbjct: 377 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 436 Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH Sbjct: 437 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 469 >1AD3-A nrPDB Length = 452 Score = 790 bits (2040), Expect = 0.0, Method: Compositional matrix adjust. Identities = 368/450 (81%), Positives = 414/450 (92%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 IS+ VKRAR AF+SG+TR LQFRIQQLEALQR+I E + + GALA+DL KNEW +YYEE Sbjct: 3 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 62 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 V +VLEE++ I++LP+WA DEPV KT QTQQD+LYIHSEPLGVVLVIG WNYPFNLTIQ Sbjct: 63 VAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQ 122 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDH 183 PMVGA+AAGN+V+LKPSE+S +MA LLAT+IPQY+D++LY V+ GGVPETTELLKERFDH Sbjct: 123 PMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDH 182 Query: 184 ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQT 243 I+YTGST VGKI+M AAAKHLTPVTLELGGKSPCYVDK+CDLDVACRRIAWGKFMNSGQT Sbjct: 183 IMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQT 242 Query: 244 CVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKV 303 CVAPDYILCDPSIQNQIVEKLKKSLK+FYGEDAK+SRDYGRII+ RHFQRV GLI+ QKV Sbjct: 243 CVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKV 302 Query: 304 AYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLA 363 A+GGT D ++RYIAPTIL DVDPQSPVMQEEIFGPV+PIVCVRSLEEAIQFINQREKPLA Sbjct: 303 AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLA 362 Query: 364 LYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFS 423 LY+FS+N+KVIKKMIAETSSGGV ANDVIVHIT+ +LPFGGVGNSGMG+YHGKKSFETFS Sbjct: 363 LYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFS 422 Query: 424 HRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453 HRRSCLV+ L+N+E K RYPPSPAKM +H Sbjct: 423 HRRSCLVKSLLNEEAHKARYPPSPAKMPRH 452 >4QGK-A nrPDB Length = 461 Score = 659 bits (1701), Expect = 0.0, Method: Compositional matrix adjust. Identities = 297/439 (67%), Positives = 377/439 (85%) Query: 8 VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67 V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V Sbjct: 6 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 65 Query: 68 LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127 L EI++M++ LPEW +PV+K T DE YI +PLGVVL+IG WNYPF LTIQP++G Sbjct: 66 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 125 Query: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187 AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT Sbjct: 126 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 185 Query: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247 G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP Sbjct: 186 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 245 Query: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307 DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG Sbjct: 246 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 305 Query: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367 D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F Sbjct: 306 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 365 Query: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427 S N K+IK+MI ETSSGGV NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R Sbjct: 366 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 425 Query: 428 CLVRPLMNDEGLKVRYPPS 446 CL++ L + K+RYPP+ Sbjct: 426 CLLKSLKREGANKLRYPPN 444 >5NNO-A nrPDB Length = 546 Score = 398 bits (1023), Expect = e-111, Method: Compositional matrix adjust. Identities = 216/465 (46%), Positives = 300/465 (64%), Gaps = 22/465 (4%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + I V + R AF+ R L+ R Q L +L L++E E A+ D ++ Sbjct: 14 LENIPVIVSKCREAFNDDANRDLKKRKQVLRSLLNLVEENTDEFCKAIHRDRRRHRDETV 73 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQ--TQQDELYIHSEPLGVVLVIGTWNYPF 118 E++ + E+ ++I+ + E+ +PV+ T + D+ + EPLGVVLVIGTWNYP Sbjct: 74 VMEILPLRNEVWHLIEHMDEYV--KPVKPTMEGAAALDDCELQYEPLGVVLVIGTWNYPL 131 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLK 178 L +QP++GA+AAGN+ V+KPSEL+ A LL ++P+Y+ D+ ++NGGV ETT +LK Sbjct: 132 LLILQPLLGALAAGNTAVIKPSELAPATAELLTKLLPKYVSSDVVGIVNGGVSETTAVLK 191 Query: 179 ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNC--DLDVACRRIAWGK 236 ERFDHILYTGS V +I+M AAAKHLTPVTLELGGKSP VD C ++ V RI WGK Sbjct: 192 ERFDHILYTGSARVAEIVMAAAAKHLTPVTLELGGKSPVVVDDTCADNMKVVAERIMWGK 251 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKK----------------SR 280 +N+GQT +APDY++ + S+++ +V+ L ++ K G+ K Sbjct: 252 IINAGQTSIAPDYVVVEKSMESVLVDALAEARKAMLGDKFLKVLKGELLVKQKQQFLEES 311 Query: 281 DYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVL 340 DY RI++A HFQR+M ++G KVA GG D AT IAPTILT++DP PVMQEEIFGP+L Sbjct: 312 DYPRIVNASHFQRLMEFMKGGKVAVGGEADEATLTIAPTILTNIDPTHPVMQEEIFGPIL 371 Query: 341 PIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSL 400 P++ + ++ ++ IN REKPLALY+FS+N + I+ + + TSSG V NDV+VH L Sbjct: 372 PVLTYENEKDILKIINSREKPLALYVFSNNKRFIRGVESRTSSGAVVVNDVVVHAGADGL 431 Query: 401 PFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPP 445 PFGGVG SGMG+YHG+ SFETFSHRR + R + VR+PP Sbjct: 432 PFGGVGRSGMGAYHGRYSFETFSHRRPVMRRGFLFSSIDTVRFPP 476 >5UCD-A nrPDB Length = 457 Score = 310 bits (793), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 165/434 (38%), Positives = 251/434 (57%), Gaps = 7/434 (1%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 +KI +A F++ T + FR Q LE L+ + ++ L ALA DL K + Sbjct: 28 AKIDSLFSAQKAYFATRATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVVDL 87 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 E+ VL EI++ + L EW A V E Y+ EP GV +IG +NYP NLT Sbjct: 88 AEIGAVLHEIDFALAHLDEWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVNLT 147 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERF 181 + P++GAI GN+ ++KPSE + ++++ II + + VI GG E + LL F Sbjct: 148 LTPLIGAIIGGNTCIIKPSETTPETSAVIEKIIAEAFAPEYVAVIQGGRDENSHLLSLPF 207 Query: 182 DHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSG 241 D I +TGS VGK++M AAAKHLTPV LELGGK P V + DLD ++ +GKF+NSG Sbjct: 208 DFIFFTGSPNVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKFINSG 267 Query: 242 QTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQ 301 QT +APDY+ S+++ ++E+L + +K + + G++++ R QR++ L+E Sbjct: 268 QTXIAPDYLYVHYSVKDALLERLVERVK----TELPEINSTGKLVTERQVQRLVSLLEAT 323 Query: 302 --KVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQRE 359 +V G D + R ++ T++ V+ P+M EE+FGP+LP++ S+ AI +N+ Sbjct: 324 QGQVLVGSQADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNKHH 383 Query: 360 -KPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKS 418 KPLA+Y+F + V K +I + SG N V++H LPFGG+G SGMG YHG S Sbjct: 384 PKPLAVYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGEYHGHFS 443 Query: 419 FETFSHRRSCLVRP 432 + TF+H++S + P Sbjct: 444 YLTFTHKKSVRIVP 457 >6QAO-A nrPDB Length = 508 Score = 164 bits (416), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 128/444 (28%), Positives = 211/444 (47%), Gaps = 24/444 (5%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 +++ AV+ A+AAF + R + L R+I+E+E E+ + K+ + A Sbjct: 64 EVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL- 122 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 ++ + +EY AA E Y EPLGV + IG WNYPF + Sbjct: 123 DIDISWQCLEYYAG----LAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIAS 178 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERF 181 A+A GN++V KPS + A LLA I + + L+ V+ GG T + L + Sbjct: 179 WKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHP 237 Query: 182 D--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 D + +TGS G IM +AK + PVTLELGGKSP + +CD++ A + F+ Sbjct: 238 DVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLT 297 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298 GQ C + I ++ E++ K + G+ + G +I+ H +RV+G + Sbjct: 298 QGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV 357 Query: 299 -----EGQKVAYGGT----GDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346 +G KV GG D + Y+ P +LT+ ++EEIFGPV+ I+ Sbjct: 358 KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFD 417 Query: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406 + E ++ N LA +F+ + + +++AE +G N+ +++ LPFGG Sbjct: 418 TEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYK 475 Query: 407 NSGMGSYHGKKSFETFSHRRSCLV 430 SG G +G+ + E +S ++ V Sbjct: 476 KSGFGRENGRVTIEYYSQLKTVCV 499 >5FHZ-A nrPDB Length = 529 Score = 160 bits (405), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 120/442 (27%), Positives = 206/442 (46%), Gaps = 20/442 (4%) Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + +AV+ A+ AF G R R + L L L++ L D K +A+ Sbjct: 88 VDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAF 147 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 + ++ + + Y WA + P + EP+GV I WN+P + Sbjct: 148 FIDLEGCIRTLRYFAG----WADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLM 203 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179 + + A+ GN++VLKP+E + A L ++I + + ++ G P + Sbjct: 204 LVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISS 263 Query: 180 --RFDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 + + I +TGST VGK++ AA++ +L VTLELGGK+PC V + DLD+A G Sbjct: 264 HPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGV 323 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295 F N GQ C A + + + ++ V + ++ + K G+ + G I + F +++ Sbjct: 324 FFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKIL 383 Query: 296 GLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 LI EG K+ GG+ + +I PT+ ++V + +EEIFGPV PI+ +S+E Sbjct: 384 ELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIE 443 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 E I+ N + L +F+ N K+ + SG V N + PFGG SG Sbjct: 444 EVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKMSG 501 Query: 410 MGSYHGKKSFETFSHRRSCLVR 431 G G+ + ++ ++ ++ Sbjct: 502 NGRELGEYALAEYTEVKTVTIK 523 >3TY7-A nrPDB Length = 478 Score = 159 bits (403), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 114/346 (32%), Positives = 167/346 (48%), Gaps = 17/346 (4%) Query: 96 DELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIP 155 D+L + E +GV +I WN+P N T + A AAG+ VVLKPSE + A +LA I Sbjct: 132 DDLVVK-EAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVVLKPSEETPFAAVILAEIFD 190 Query: 156 QY-LDKDLYPVINGGVPETTELLKE--RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELG 212 + + K ++ ++NG L E + + +TGS G IM AAK V+LELG Sbjct: 191 KVGVPKGVFNLVNGDGAGVGNPLSEHPKVRMMSFTGSGPTGSKIMEKAAKDFKKVSLELG 250 Query: 213 GKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF- 271 GKSP V + D+ A + N+GQ C A +L I++ + +LK+ + Sbjct: 251 GKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLVPNKIKDAFLAELKEQFSQVR 310 Query: 272 YGEDAKKSRDYGRIISARHFQRVM-----GLIEGQKVAYGGTGD----AATRYIAPTILT 322 G + G IIS + F +V G+ EG ++ YGG G + PTI Sbjct: 311 VGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYGGPGKPEGLEKGYFARPTIFI 370 Query: 323 DVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETS 382 +VD Q + QEEIFGPV+ ++ L+EAIQ N + LA Y+ + + + K+ Sbjct: 371 NVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGLAGYVIGKDKETLHKVARSIE 430 Query: 383 SGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSC 428 +G V N+ LPFGG SG+G G E F +S Sbjct: 431 AGTVEINEAGRK---PDLPFGGYKQSGLGREWGDYGIEEFLEVKSI 473 >4V3F-A nrPDB Length = 497 Score = 158 bits (399), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 128/434 (29%), Positives = 200/434 (46%), Gaps = 25/434 (5%) Query: 7 AVKRARAAFSSGRTRPLQ--FRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEV 64 AV AR AF R L A+ I E++ V D K ++E Sbjct: 50 AVVAARRAFRRNNWSATSGAHRATYLRAIAAKITEKKDHFVKLETIDSGKP-----FDEA 104 Query: 65 VYVLEEIEYMIQKLPEWA-ADEPVEKTPQT---QQDELYIHSEPLGVVLVIGTWNYPFNL 120 V ++++ + A A + +K P T ++ + ++ +PLGVV +I WNYP + Sbjct: 105 VLDIDDVASCFEYFAGQAEALDGKQKAPVTLPMERFKSHVLRQPLGVVGLISPWNYPLLM 164 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179 + A+AAG + VLKPSEL+ + + L + ++ G P+ L Sbjct: 165 ATWKIAPALAAGCTAVLKPSELASVTCLEFGEVCNEVGLPPGVLNILTGLGPDAGAPLVS 224 Query: 180 R--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKF 237 D I +TGS+ G +M +AA+ + PVTLELGGKSP V ++ D+D +G F Sbjct: 225 HPDVDKIAFTGSSATGSKVMASAAQLVKPVTLELGGKSPIVVFEDVDIDKVVEWTIFGCF 284 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDA-KKSRDYGRIISARHFQRVMG 296 +GQ C A +L SI + V+KL K K D ++ G +IS + ++M Sbjct: 285 WTNGQICSATSRLLVHESIAAEFVDKLVKWTKNIKISDPFEEGCRLGPVISKGQYDKIMK 344 Query: 297 LI-----EGQKVAYGGTGDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 I EG + YGG+ + YI PTI+TD+ + +EE+FGPVL + S Sbjct: 345 FISTAKSEGATILYGGSRPEHLKKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTFSSE 404 Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408 +EAI N E LA +FS++ + +++ G V N P+GG+ S Sbjct: 405 DEAIALANDTEYGLAAAVFSNDLERCERITKALEVGAVWVN--CSQPCFVQAPWGGIKRS 462 Query: 409 GMGSYHGKKSFETF 422 G G G+ + + Sbjct: 463 GFGRELGEWGIQNY 476 >2HG2-A nrPDB Length = 479 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 108/328 (32%), Positives = 169/328 (51%), Gaps = 16/328 (4%) Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDE-LYIHSEPLGVVLVIGTWNYPFNLT 121 EV + + I+YM EWA E + E + + LGV I WN+PF L Sbjct: 104 EVAFTADYIDYM----AEWARRYEGEIIQSDRPGENILLFKRALGVTTGILPWNFPFFLI 159 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVING-GVPETTELLKE 179 + M A+ GN++V+KPSE + N A A I+ + L + ++ ++ G G EL Sbjct: 160 ARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGN 219 Query: 180 -RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 + + TGS G+ IM AAK++T V LELGGK+P V + DL++A + I + + Sbjct: 220 PKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVI 279 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSR-DYGRIISARHFQRV-- 294 NSGQ C + + I +Q V +L ++++ +G A+++ G +I+A +RV Sbjct: 280 NSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQ 339 Query: 295 ---MGLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350 + EG +VA+GG + Y PT+L DV + +M EE FGPVLP+V +LE+ Sbjct: 340 KVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLED 399 Query: 351 AIQFINQREKPLALYMFSSNDKVIKKMI 378 AI N + L +++ N V K I Sbjct: 400 AISMANDSDYGLTSSIYTQNLNVAMKAI 427 >4CAZ-A nrPDB Length = 490 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 122/424 (28%), Positives = 199/424 (46%), Gaps = 28/424 (6%) Query: 27 IQQLEALQR---LIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAA 83 +Q+ L+R +++E+ EL D K ++V + +EY +P Sbjct: 66 MQRSRILRRAVDILRERNDELAALETLDTGKPLAETRSVDIVTGADVLEYYAGLVPAIEG 125 Query: 84 DEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELS 143 E+ P + +Y EPLGVV IG WNYP + + A+AAGN+++ KPSE++ Sbjct: 126 ----EQIPLRETSFVYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSEVT 181 Query: 144 ENMASLLATIIPQYLDKD-LYPVINGGVPETTELLKER--FDHILYTGSTGVGKIIM-TA 199 A LA I + D ++ V+ G E + L E + I +TG T GK +M +A Sbjct: 182 PLTALKLAEIYTEAGVPDGVFNVLTGSGREVGQWLTEHPLIEKISFTGGTSTGKKVMASA 241 Query: 200 AAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ 259 ++ L VT+ELGGKSP + + DLD A F +SGQ C + S Q + Sbjct: 242 SSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQAR 301 Query: 260 IVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE------------GQKVAYG 306 K+ + ++ G+ ++ ++G ++S H + V+G IE G++V G Sbjct: 302 FEAKVLERVQRIRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVTDG 361 Query: 307 GTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYM 366 G A Y+APT+ TD +++EEIFGPV+ I+ +EAI+ N E LA + Sbjct: 362 AFGKGA--YVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGV 419 Query: 367 FSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRR 426 + + + I +G N + +P GG SG+G +G + ++ + Sbjct: 420 VTQDLARAHRAIHRLEAGICWIN--TWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIK 477 Query: 427 SCLV 430 S V Sbjct: 478 SVQV 481 >5GT6-A nrPDB Length = 508 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 134/444 (30%), Positives = 204/444 (45%), Gaps = 26/444 (5%) Query: 4 ISEAVKRARAAFSSGRTRPLQF--RIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 I AVK AR+AF SG + R + L LI+E +EL A D K A Sbjct: 73 IDAAVKAARSAFESGPWAEMTTAERAHLIYKLADLIEEHREELAQLEALDNGKPYQVALD 132 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 +++ +E Y W + P ++ Y EP+GVV I WN+P ++ Sbjct: 133 DDISATVENYRY----YAGWTTKIIGQTIPISKDYLNYTRHEPVGVVGQIIPWNFPLVMS 188 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP--VIN---GGVPETTEL 176 M A+A G ++VLKP+E + SLL + + +P V+N G PE Sbjct: 189 SWKMGAALATGCTIVLKPAE--QTPLSLLYA--AKLFKEAGFPNGVVNFVPGFGPEAGAA 244 Query: 177 L--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 + D + +TGST GK IM +A+ + VTLELGGKSP + ++ DL+ A Sbjct: 245 IVNHHDIDKVAFTGSTVTGKYIMRQSAEMIKHVTLELGGKSPNIILEDADLEEAINGAFQ 304 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293 G N GQ C A + +V+ L K G +K + G ++S + +R Sbjct: 305 GIMYNHGQNCSAGSRVFVHRKHYETVVDALVKMANNVKLGAGMEKETEMGPLVSKKQQER 364 Query: 294 VMGLI-----EGQKVAYGGTGDAATRY-IAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 V+ I EG VA GG Y + PT+ TDV +++EEIFGPV+ ++ S Sbjct: 365 VLNYIEQGKKEGATVAAGGERALEKGYFVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDS 424 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 EE I+ N LA +++ N K ++ + +G V ND ++ + PFGG Sbjct: 425 TEEVIERANNSSYGLAAGVWTQNIKTGHQVANKLKAGTVWIND--YNLENAAAPFGGYKQ 482 Query: 408 SGMGSYHGKKSFETFSHRRSCLVR 431 SG+G G + + ++ +S V Sbjct: 483 SGIGRELGSYALDNYTEVKSVWVN 506 >5AC0-A nrPDB Length = 501 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 131/444 (29%), Positives = 209/444 (47%), Gaps = 24/444 (5%) Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + +AVK AR AF G RT R + L L LI+ L A + K NAY Sbjct: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAY 119 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 ++ ++ + Y WA P Y SEP+GV I WN+P + Sbjct: 120 LMDLGGCIKTLRY----CAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLM 175 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179 + + A++ GN+VV+KP+E + A + ++I + + ++ G P + Sbjct: 176 FLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISS 235 Query: 180 RFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 D + +TGST VGK+I AA K +L V+LELGGKSPC V + DLD A G Sbjct: 236 HMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGV 295 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295 F + GQ C+A + + SI ++ V + ++++ K G G I +++++ Sbjct: 296 FYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEKIL 355 Query: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 LI EG K+ GG G + +I PT+ +DV + +EEIFGPV I+ +SL Sbjct: 356 DLIESGKKEGAKLECGG-GPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSL 414 Query: 349 EEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 ++ I+ N L+ +F+++ DK I + + SG V N + PFGG Sbjct: 415 DDVIKRANNTFYGLSAGIFTNDIDKAI-TVSSALQSGTVWVN--CYSVVSAQCPFGGFKM 471 Query: 408 SGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ F ++ ++ ++ Sbjct: 472 SGNGRELGEYGFHEYTEVKTVTIK 495 >5AC2-A nrPDB Length = 501 Score = 154 bits (390), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 133/447 (29%), Positives = 209/447 (46%), Gaps = 30/447 (6%) Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + +AVK AR AF G RT R + L L LI+ L + + K NAY Sbjct: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 ++ ++ + Y WA P Y EP+GV I WN+P + Sbjct: 120 LNDLAGCIKTLRY----CAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179 I + A++ GN+VV+KP+E + A +A++I + + ++ G P + Sbjct: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235 Query: 180 RFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 D + +TGST VGK+I AA K +L VTLELGGKSPC V + DLD A G Sbjct: 236 HMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGV 295 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295 F + GQ C+A I + SI ++ V + ++++ K G G I + +++ Sbjct: 296 FYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKIL 355 Query: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 LI EG K+ GG G + ++ PT+ ++V + + +EEIFGPV I+ +SL Sbjct: 356 DLIESGKKEGAKLECGG-GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSL 414 Query: 349 EEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAANDVIVH---ITLHSLPFGG 404 ++ I+ N L+ +F+ + DK I T S + A V V+ + PFGG Sbjct: 415 DDVIKRANNTFYGLSAGVFTKDIDKAI------TISSALQAGTVWVNCYGVVSAQCPFGG 468 Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ F ++ ++ V+ Sbjct: 469 FKMSGNGRELGEYGFHEYTEVKTVTVK 495 >5EUY-A nrPDB Length = 491 Score = 154 bits (389), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 119/457 (26%), Positives = 214/457 (46%), Gaps = 28/457 (6%) Query: 6 EAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVV 65 EA+ A A + P R + L + + ++ +++ + L + + + EVV Sbjct: 50 EAIDSAFEALKAWANIPAIRRAEYLYKMLEVFRQMKEDFMKILTVE-GGGTYRKVWGEVV 108 Query: 66 YVLEEIEYMIQKLPEWA---ADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 + E +IQ E A ++ ++ ++ S+ GVV VI WNYP ++++ Sbjct: 109 FT----ERLIQNAAELARHYQGRVLQSDSESTISVVFKRSK--GVVGVITPWNYPLSISM 162 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTE--LLKE 179 + + +A GN+VV KP+ + L+A ++ + L K ++ ++ G P E + + Sbjct: 163 KKIAHTLAVGNTVVYKPASDTPVTGWLIAQMVAKAGLPKGVFNLVIGPGPVVGEEIVTHK 222 Query: 180 RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 R H+ +TG + G+ I AA L VTLELGG P + + D+D A R + + Sbjct: 223 RVAHVTFTGESSTGREIAAKAAGTLKTVTLELGGSDPLIILDDVDVDYAARLAVFASLFH 282 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSR--DYGRIISARHFQRVMGL 297 GQ C + I+ ++ ++ +E+ +K +D +K D G +I+ R + Sbjct: 283 QGQICTSAKRIIVHKAVADKFIERYVHYVKMLRIDDPRKDEKVDLGPLINERQVALMKEF 342 Query: 298 IEGQKVAYGGT----GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQ 353 ++ V+ GG G + + P I DVD +M+EE+FGPV PIV V + ++A++ Sbjct: 343 VD-DAVSRGGRLLIGGRSWGNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQAVE 401 Query: 354 FINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSY 413 N + L+ + ++N ++ SG NDV H +PFGG+ SG+G Sbjct: 402 VANDTDYGLSGAVLTNNVNRAFRIAEAVESGMFHINDVTFLEESH-VPFGGIKASGVGRE 460 Query: 414 HGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKM 450 G+ SF ++ R V L+ R P P+ + Sbjct: 461 GGEWSFHETTYDRWVTVT-------LRTRRFPIPSAL 490 >3K2W-A nrPDB Length = 497 Score = 154 bits (389), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 116/360 (32%), Positives = 172/360 (47%), Gaps = 25/360 (6%) Query: 91 PQTQQDE-LYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASL 149 P QDE +YIH P GVV+ I WN+P L + + A+ GN++VLKP++ + + Sbjct: 134 PSDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKPTQETPLATTE 193 Query: 150 LATIIPQY-LDKDLYPVINGGVPETTELLKER--FDHILYTGSTGVGKIIMTAAAKHLTP 206 L I + L + VING + L E I TGST GK I +A+++TP Sbjct: 194 LGRIAKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTGSTVAGKQIYKTSAEYMTP 253 Query: 207 VTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK--- 263 V LELGGK+P V + DLD A WG+F N GQ C + + S+ ++ + K Sbjct: 254 VMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASVYDEFMAKFLP 313 Query: 264 LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGT-----GDAAT 313 L K LK G+ G + R + ++ +G VA GG G Sbjct: 314 LVKGLK--VGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTATVEGFEGG 371 Query: 314 RYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKV 373 + PT+L DV + V+ EE FGP+LPIV V S+E+AI+F N L+ Y+ + + Sbjct: 372 CWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAYVHTQSFAN 431 Query: 374 IKKMIAETSSGGVAANDVI--VHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 I + I++ G V N + H H+ G SG G GK E + +++ + Sbjct: 432 INQAISDLEVGEVYINRGMGEQHQGFHN----GWKQSGFGGEDGKFGLEQYLEKKTVYIN 487 >3RJL-A nrPDB Length = 538 Score = 152 bits (384), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 120/428 (28%), Positives = 195/428 (45%), Gaps = 25/428 (5%) Query: 6 EAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVV 65 +A++ A AF + R + R L ++ ++ E L + K WN + Sbjct: 78 KAIQAAAKAFETWRYTDPEERAAVLFRAVAKVRRKKHEFSALLVKEAGK-PWNEADADTA 136 Query: 66 YVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPM 125 ++ +EY +++ E A +PV + +Y P GV +VI WN+ F + Sbjct: 137 EAIDFMEYYARQMIELAKGKPVNSREGERNQYVYT---PTGVTVVIPPWNFLFAIMAGTT 193 Query: 126 VGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFDH- 183 V I GN+VVLKP+ + +A+ ++ + L K + + G E + L DH Sbjct: 194 VAPIVTGNTVVLKPASAAPVIAAKFVEVLEESGLPKGVVNFVPGSGAEVGDYL---VDHP 250 Query: 184 ----ILYTGSTGVGKIIMTAAAK------HLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 I +TGS VG I AAK HL V E+GGK VD++CD+++A + I Sbjct: 251 KTSIITFTGSREVGTRIFERAAKVQPGQTHLKQVIAEMGGKDTVVVDEDCDIELAAQSIF 310 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQ 292 F +GQ C A + + ++++++ ++ + + GE G +I F Sbjct: 311 TSAFGFAGQKCSAGSRAVVHEKVYDEVLKRVIEITESKKVGEPDSADVYMGPVIDQASFN 370 Query: 293 RVMGLIE-----GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 ++M IE G+ V+ G D+ +I PTI D+DP++ +MQEEIFGPV+ V S Sbjct: 371 KIMDYIEIGKEEGRLVSGGKGDDSKGYFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSS 430 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 +EA++ N E L + + N I + E G + N + PFGG Sbjct: 431 FDEALEVANNTEYGLTGAVITKNRDHINRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKM 490 Query: 408 SGMGSYHG 415 SG S G Sbjct: 491 SGTDSKAG 498 >3QAN-A nrPDB Length = 538 Score = 152 bits (384), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 120/428 (28%), Positives = 193/428 (45%), Gaps = 25/428 (5%) Query: 6 EAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVV 65 +A++ A AF + R + R L +I+ ++ E L + K W + Sbjct: 78 KAIQSADEAFQTWRNVNPEERANILVKAAAIIRRRKHEFSAWLVHEAGK-PWKEADADTA 136 Query: 66 YVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPM 125 ++ +EY +++ E + + P Q Y P+GV + I WN+ + + Sbjct: 137 EAIDFLEYYARQMIELNRGKEILSRPGEQNRYFYT---PMGVTVTISPWNFALAIMVGTA 193 Query: 126 VGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFDH- 183 V I GN+VVLKP+ + +A+ ++ L K + + G E + L DH Sbjct: 194 VAPIVTGNTVVLKPASTTPVVAAKFVEVLEDAGLPKGVINYVPGSGAEVGDYL---VDHP 250 Query: 184 ----ILYTGSTGVGKIIMTAAA------KHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 I +TGS VG + AA HL V +E+GGK VD++ DLD+A I Sbjct: 251 KTSLITFTGSKDVGVRLYERAAVVRPGQNHLKRVIVEMGGKDTVVVDRDADLDLAAESIL 310 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDY-GRIISARHFQ 292 F SGQ C A + + ++++EK K D +Y G +I + F+ Sbjct: 311 VSAFGFSGQKCSAGSRAVIHKDVYDEVLEKTVALAKNLTVGDPTNRDNYMGPVIDEKAFE 370 Query: 293 RVMGLIE-GQK---VAYGGTGDAATRY-IAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 ++M IE G+K + GG GD++T + I PTI+ D+DP++ +MQEEIFGPV+ Sbjct: 371 KIMSYIEIGKKEGRLMTGGEGDSSTGFFIQPTIIADLDPEAVIMQEEIFGPVVAFSKAND 430 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 + A++ N E L + + N I++ E G + N + PFGG Sbjct: 431 FDHALEIANNTEYGLTGAVITRNRAHIEQAKREFHVGNLYFNRNCTGAIVGYHPFGGFKM 490 Query: 408 SGMGSYHG 415 SG S G Sbjct: 491 SGTDSKAG 498 >3RHD-A nrPDB Length = 486 Score = 150 bits (380), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 131/445 (29%), Positives = 205/445 (46%), Gaps = 30/445 (6%) Query: 6 EAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVV 65 EA+ A + P+ R L + + I+E+++EL LA D K A E Sbjct: 38 EAIDTAEKYKEVMKNLPITKRYNILMNIAKQIKEKKEELAKILAIDAGKPIKQARVE--- 94 Query: 66 YVLEEIEYMIQ--KLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 +E I KL + E ++ + ++ EP+G+V I +N+P NL+ Sbjct: 95 -----VERSIGTFKLAAFYVKEHRDEVIPSDDRLIFTRREPVGIVGAITPFNFPLNLSAH 149 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDK-----DLYPVINGG--VPETTEL 176 + AIA GN +V PS + + LA II L K +Y ++ G V + Sbjct: 150 KIAPAIATGNVIVHHPSSKAPLVCIELAKIIENALKKYNVPLGVYNLLTGAGEVVGDEIV 209 Query: 177 LKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 + E+ + I +TGS+ VG++I A + LELGG +P V K+ DL+ A + G Sbjct: 210 VNEKVNMISFTGSSKVGELITKKAG--FKKIALELGGVNPNIVLKDADLNKAVNALIKGS 267 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVM 295 F+ +GQ C++ IL D SI ++ +E K G + D G +IS H + V Sbjct: 268 FIYAGQVCISVGMILVDESIADKFIEMFVNKAKVLNVGNPLDEKTDVGPLISVEHAEWVE 327 Query: 296 GLI-----EGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350 ++ EG K+ GG D A Y PTIL +VD + + + E F PV+PI+ EE Sbjct: 328 KVVEKAIDEGGKLLLGGKRDKALFY--PTIL-EVDRDNILCKTETFAPVIPIIRTNE-EE 383 Query: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410 I N E L +F+++ K GGV ND + ++PFGGV SG+ Sbjct: 384 MIDIANSTEYGLHSAIFTNDINKSLKFAENLEFGGVVINDSSL-FRQDNMPFGGVKKSGL 442 Query: 411 GSYHGKKSFETFSHRRSCLVRPLMN 435 G K + E S+ ++ ++ N Sbjct: 443 GREGVKYAMEEMSNIKTIIISKAEN 467 >1O9J-A nrPDB Length = 501 Score = 150 bits (380), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 130/447 (29%), Positives = 211/447 (47%), Gaps = 30/447 (6%) Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + +AVK AR AF G RT R Q + L LI+ L + + K +AY Sbjct: 60 VDKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAY 119 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 ++ Y ++ + Y WA P + Y EP+GV +I WN P L Sbjct: 120 LMDLDYCIKALRY----CAGWADKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNAPMIL 175 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179 + A+ GN+V++KP+E + A +A++I + + ++ G P + Sbjct: 176 LACKIGPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235 Query: 180 RFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 D + +TGST VGK+I AAAK +L VTLELG K+PC V + DLD A G Sbjct: 236 HMDVDKVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQGV 295 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295 F N GQ+C+A + + +I ++ V++ ++++ K +G ++G I+ ++M Sbjct: 296 FTNQGQSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQHNKIM 355 Query: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 LI EG K+ GG G + +I PT+ ++V + +EEIFGPV I+ +SL Sbjct: 356 ELIESGKKEGAKLECGG-GPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSL 414 Query: 349 EEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAANDVIVHITLHS---LPFGG 404 +E I+ N L +F+ + DK + T S + A V V+ L + P GG Sbjct: 415 DEVIKRANNTYYGLVAGVFTKDLDKAV------TVSSALQAGTVWVNCYLAASAQSPAGG 468 Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ ++ ++ ++ Sbjct: 469 FKMSGHGREMGEYGIHEYTEVKTVTMK 495 >3I44-A nrPDB Length = 497 Score = 150 bits (379), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 122/434 (28%), Positives = 204/434 (47%), Gaps = 32/434 (7%) Query: 6 EAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVV 65 +A+ A+ AF + +T R+ +E + + +++ ++ ++ ++ A + Sbjct: 67 KAINAAKKAFQTWKTTSPHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNAQTA 126 Query: 66 YVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPM 125 I I+ E++ E + + ++ +H + +GVV +I WN+P N + Sbjct: 127 TGSSHIRNFIKAYKEFSFQEALIEG----NEQAILHYDAIGVVGLITPWNWPMNQVTLKV 182 Query: 126 VGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFD-- 182 + A+ AG ++VLKPSE++ A L A I+ + L ++ +ING L D Sbjct: 183 IPALLAGCTMVLKPSEIAPLSAMLFAEILDEAALPSGVFNLINGDGANVGSYLSAHPDLE 242 Query: 183 HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQ 242 I +TGST GK I A+ L V LELGGK + + D+D A +R F NSGQ Sbjct: 243 MISFTGSTRAGKDISKNASNTLKRVCLELGGKGANIIFADADID-ALQRGVRHCFYNSGQ 301 Query: 243 TCVAPDYILCDPSIQNQIVEKLKK-SLKEFYGEDAKKSRDYGRIISARHFQRVMGLI--- 298 +C AP +L + +I ++ ++ K + K G + G ++S + ++ LI Sbjct: 302 SCNAPTRMLVEQAIYDKAIKTAKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLIQSG 361 Query: 299 --EGQKVAYGGTGDAATR----YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAI 352 EG + GGTG Y+ PT+ DV P + +EEIFGPVL ++ + +EA+ Sbjct: 362 IDEGATLVTGGTGLPMGMERGYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTEDEAV 421 Query: 353 QFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLP----FGGVGNS 408 N E L Y+ S + +++ A+ SG +V + H LP FGGV S Sbjct: 422 TLANDTEYGLTNYIQSQDRSKCRRIAAQVRSG-------MVEVNGHELPGGSYFGGVKFS 474 Query: 409 GM---GSYHGKKSF 419 G G G K F Sbjct: 475 GRAREGGLWGIKEF 488 >4I8Q-A nrPDB Length = 514 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 112/337 (33%), Positives = 168/337 (49%), Gaps = 15/337 (4%) Query: 99 YIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY- 157 Y+ EPLGVV +I WNYP + I + A+AAG + +LKPSEL+ L I + Sbjct: 159 YVLREPLGVVGLITPWNYPLLMAIWKVAPALAAGCAAILKPSELASITCLELGEICREIG 218 Query: 158 LDKDLYPVINGGVPETTELLKE--RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKS 215 L ++ G PE L D I +TGS G IMTAAA+ + PV+L LGGKS Sbjct: 219 LPSGALNILTGLGPEAGGPLASHPHVDKISFTGSGPTGSKIMTAAAQLVKPVSLALGGKS 278 Query: 216 PCYVDKNCD-LDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGE 274 P V + D LD+A +G F N+GQ C A ++ +I + +++L K K Sbjct: 279 PIVVFDDIDNLDIAAEWTLFGIFANTGQVCSATSRLIVQENIASAFMDRLLKWTKNIKIS 338 Query: 275 DA-KKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGTGDAATR---YIAPTILTDVD 325 D ++ G ++SA +++V+ I EG + GG + Y+ PTI+TDV+ Sbjct: 339 DPLEEDCKLGPVVSAGQYEKVLKFISNAKSEGATILCGGERPQHLKKGYYVQPTIITDVN 398 Query: 326 PQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGG 385 + +EE+FGPVL + ++ E+AI+ N + L + S + K ++ +G Sbjct: 399 TSMEIWKEEVFGPVLCVKTFKTEEQAIELANDTKYGLGAAVMSKDVKRCERFTKAFQTGI 458 Query: 386 VAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETF 422 + N T + LP+GG SG G GK E F Sbjct: 459 IWIN--CSQPTFNELPWGGKKRSGFGRDLGKWGLENF 493 >3U4J-A nrPDB Length = 528 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 110/339 (32%), Positives = 173/339 (51%), Gaps = 13/339 (3%) Query: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKD- 161 EP+GVV +I WN+PF + + + AI +G +VVLKPSE + + LA + + D Sbjct: 160 EPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVLKPSEFTSGTSIRLAELAREAGIPDG 219 Query: 162 LYPVINGGVPETTELLKE--RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYV 219 ++ V+ G ++L E D + +TGS VG + AA+ + V LELGGK P V Sbjct: 220 VFNVVTGYGDPAGQVLAEDPNVDMVAFTGSVRVGTKLGEIAARTVKRVGLELGGKGPQIV 279 Query: 220 DKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKEFYGEDAKK 278 + DLD A IA+G + N+GQ C++ +L I++ ++E+L S K +G+ + Sbjct: 280 FADADLDAAADGIAYGVYHNAGQCCISGSRLLVQEGIRDALMERLLDISRKVAFGDPLNE 339 Query: 279 SRDYGRIISARHFQRV-----MGLIEGQKVAYGG--TGDAATRYIAPTILTDVDPQSPVM 331 G +IS H ++V G+ G ++ GG G A Y APT+ V P + Sbjct: 340 RTKIGAMISEAHAEKVHSYVTAGITSGAELLLGGERIGREAGLYYAPTVFAGVTPDMSIA 399 Query: 332 QEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDV 391 +EEIFGPVL + ++ +EA+ N E L+ ++S+N + + I +G N V Sbjct: 400 REEIFGPVLSTLTFKTADEAVALANATEFGLSASVWSTNLETALQTIRRIRAGRCWINSV 459 Query: 392 IVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 I LP GG SG+G G+ F+ +S + V Sbjct: 460 IDGTP--ELPIGGYKKSGLGRELGRYGFDEYSQFKGVHV 496 >4O5H-A nrPDB Length = 511 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 109/345 (31%), Positives = 169/345 (48%), Gaps = 18/345 (5%) Query: 99 YIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATII--PQ 156 Y EP+GVV I WN+P + + A+A G +VVLKP+E + A L +I Sbjct: 169 YTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTVVLKPAEDTPLSALRLGELIQAAG 228 Query: 157 YLDKDLYPVINGGVPETTELLKE-RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKS 215 + D + V G L ++ R D I +TGST GK I AA ++T ++LELGGKS Sbjct: 229 FPDGVVNIVTGYGHTAGAALSRDPRIDKIAFTGSTQTGKTIGHAALDNMTRMSLELGGKS 288 Query: 216 PCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKK---SLKEFY 272 P V + DLD A + +A F N GQ C A + + ++E++ K SLK Sbjct: 289 PVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYIHSKVFDGVIERVAKIAASLKIGP 348 Query: 273 GEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTG------DAATRYIAPTILTDVDP 326 G D + G ++SA+ +RV G I+ D ++ PT+L D Sbjct: 349 GMD--PATQIGPLVSAKQRERVCGYIDSGFGEGARAAAGGRAIDGPGFFVEPTVLVDTTQ 406 Query: 327 QSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGV 386 V++EEIFGPVL + ++ A+Q N L ++S++ I K++ ++G V Sbjct: 407 AMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYGLGASIWSNDLSAIHKLVPRIAAGTV 466 Query: 387 AANDVIVHITL-HSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 N H L ++LPFGG+ SG G G+ + ++ +S ++ Sbjct: 467 WVN---CHSLLDNALPFGGMKQSGFGRELGRAVIDQYTESKSVMM 508 >4GO4-A nrPDB Length = 495 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 110/348 (31%), Positives = 170/348 (48%), Gaps = 21/348 (6%) Query: 99 YIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY- 157 Y+ +P+GVV I WN+P T M A+AAGN++V+KPSE++ + ++ + Sbjct: 133 YVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAAGNTIVIKPSEITPLSTLRIVELMTEVG 192 Query: 158 LDKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKS 215 K + V+ G + L E D I +TGST G+ I+ A+ +L + LELGGK Sbjct: 193 FPKGVVNVVPGYGHTAGQALAEHLDVGKIAFTGSTATGRRIVEASKSNLKRIQLELGGKG 252 Query: 216 PCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK---LKKSLKEFY 272 V ++ +++ A AW F N GQ C+A ++ I +Q +E+ L KS++ Sbjct: 253 ANIVFEDANIEAAVNGAAWAIFHNQGQACIAGSRLILHKDIADQFLERFIALAKSIR--L 310 Query: 273 GEDAKKSRDYGRIISARHFQRVMGLIE-----GQKVAYGGTGD-----AATRYIAPTILT 322 G+ + G + SA RV+ I+ G KV GG A Y+ PT++ Sbjct: 311 GDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGKVLAGGKAPDDKALANGFYVEPTVV- 369 Query: 323 DVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETS 382 + PQ V QEE+FGP + +V S EEA+ N E L +++ N KM A Sbjct: 370 EAKPQDRVCQEEVFGPFVTVVRFSSDEEALAIANNTEYGLGSGLWTQNLARAHKM-AHAI 428 Query: 383 SGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 G+ + ++ S PFGGVG SG G G ++ ++ RS V Sbjct: 429 HAGMCWINCYKRVSPGS-PFGGVGQSGYGREMGFEAIHDYTEARSVWV 475 >4I8P-A nrPDB Length = 520 Score = 149 bits (375), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 117/417 (28%), Positives = 193/417 (46%), Gaps = 23/417 (5%) Query: 22 PLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEW 81 P R + L A+ + E++ EL A D K Y+E + ++++ + + Sbjct: 87 PGAVRAKYLRAIAAKVIERKPELAKLEALDCGKP-----YDEAAWDMDDVAGCFEYFADQ 141 Query: 82 A-ADEPVEKTPQTQQDELY---IHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVL 137 A A + + +P + E + + EP+GVV +I WNYP + + A+AAG + VL Sbjct: 142 AEALDKRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVL 201 Query: 138 KPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER--FDHILYTGSTGVGK 194 KPSEL+ LA I + L + ++ G P+ L D + +TGS GK Sbjct: 202 KPSELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETGK 261 Query: 195 IIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDP 254 IM +AA + PVTLELGGKSP V + D+D A +G F +GQ C A +L Sbjct: 262 KIMASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLIHT 321 Query: 255 SIQNQIVEKLKKSLKEFYGEDA-KKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGT 308 I + E++ K D ++ G ++S ++++ I +G + GG Sbjct: 322 KIAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGGV 381 Query: 309 GDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALY 365 A +I PTI+TD+ + +EE+FGPVL + + +EAI+ N + LA Sbjct: 382 RPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLAGA 441 Query: 366 MFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETF 422 + S + + +++ E +G + N P+GG SG G G+ + + Sbjct: 442 VISGDRERCQRLSEEIDAGCIWVN--CSQPCFCQAPWGGNKRSGFGRELGEGGIDNY 496 >4PXL-B nrPDB Length = 517 Score = 148 bits (374), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 137/453 (30%), Positives = 208/453 (45%), Gaps = 32/453 (7%) Query: 2 SKISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + + AVK AR AF +G R + R + L LI E +EL D K Sbjct: 74 ADVDLAVKAAREAFDNGPWPRMTGYE-RGRILHRFADLIDEHVEELAALDTVDAGKLFAV 132 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKT-PQTQQDELYIHSEPLGVVLVIGTWNYP 117 ++ + Y AAD+ T Q+ Y EP+GVV I WNYP Sbjct: 133 GKARDIPGAAHLLRYYAG-----AADKVHGATLKMAQRMHGYTLKEPVGVVGHIVPWNYP 187 Query: 118 FNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTEL 176 + + A+AAG +VV+KP+E + A A + + + + V+ G P Sbjct: 188 TTMFFFKVGPALAAGCAVVVKPAEQTPLSALFYAHLAREAGVPAGVLNVVPGFGPTAGAA 247 Query: 177 LKERFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 + D + +TGST VG+++M AAA+ +L PV+LELGGKSP V + DLD+A + Sbjct: 248 VAAHMDVDKVSFTGSTEVGRLVMRAAAESNLKPVSLELGGKSPVIVFDDADLDMAVNLVN 307 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKEFYGEDAKKSRDYGRIISARHFQ 292 + + N G+ CVA I I ++ V+K + + K G+ S G + ++ Sbjct: 308 FATYTNKGEICVAGTRIYVQEGIYDEFVKKAAELASKSVVGDPFNPSVSQGPQVDKDQYE 367 Query: 293 RVMGLI-----EGQKVAYGG--TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 +V+ I EG + GG GD YI PTI TDV + Q+EIFGPV+ ++ Sbjct: 368 KVLRYIDIGKREGATLVTGGKPCGDKG-YYIEPTIFTDVKDDMTIAQDEIFGPVMALMKF 426 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH---SLPF 402 +++EE IQ N LA + + N V A T S + A + ++ PF Sbjct: 427 KTVEEVIQKANNTRYGLAAGIVTKNIDV-----ANTVSRSIRAGAIWINCYFAFDPDAPF 481 Query: 403 GGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMN 435 GG SG G G + + + ++ +V PL N Sbjct: 482 GGYKMSGFGKDMGMDALDKYLQTKT-VVTPLYN 513 >3IWK-A nrPDB Length = 503 Score = 148 bits (374), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 136/459 (29%), Positives = 209/459 (45%), Gaps = 26/459 (5%) Query: 7 AVKRARAAFSSGRTRPLQ-----FRIQQLEALQRLIQEQEQELVGALAADLHK--NEWNA 59 AV A+ A S R R + L A+ I+E++ EL + D K E A Sbjct: 50 AVDAAKRAISRKNGRDWSAASGSLRARYLRAIAAKIKEKKDELGKLESIDCGKPLEEALA 109 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 ++VV E + ++L P+ T + YI EP+GVV +I WNYPF Sbjct: 110 DLDDVVACFEYYAGLAEELDS-KQKAPISLPMDTFKS--YILKEPIGVVALITPWNYPFL 166 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK 178 + + A+AAG + +LKPSEL+ L I + L + + ++ G E L Sbjct: 167 MATWKIAPALAAGCAAILKPSELASVTCLELGEICKEVGLPRGVLNIVTGLGHEAGASLA 226 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 D I +TGS+ G IMT AA+ + PV+LELGGKSP V ++ DLD +G Sbjct: 227 SHPDVDKISFTGSSATGSKIMTTAAQLVKPVSLELGGKSPIVVFEDVDLDKVAEWTVFGC 286 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDA-KKSRDYGRIISARHFQRVM 295 F +GQ C A ++ SI + V+KL K + D ++ G I+S +++V+ Sbjct: 287 FFTNGQICSATSRLIVHESIAVEFVDKLVKWAENIKISDPLEEGCRLGPIVSEAQYKKVL 346 Query: 296 GLI-----EGQKVAYGGTGDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 I EG + GG + ++ PTI+TDV + +EE+FGPVL + + Sbjct: 347 NCISSAKSEGATILTGGRRPEHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLAVKTFST 406 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 EEAI N L + S++ + +++ +G V N + P+GG+ Sbjct: 407 EEEAINLANDTHYGLGSAVMSNDLERCERLSKALQAGIVWIN--CAQPSFIQAPWGGIKR 464 Query: 408 SGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPS 446 SG G G+ E + + V +DE PPS Sbjct: 465 SGFGRELGEWGLENYLSVKQ--VTRYTSDEPWGWYQPPS 501 >4LIH-A nrPDB Length = 504 Score = 148 bits (374), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 112/330 (33%), Positives = 164/330 (49%), Gaps = 14/330 (4%) Query: 114 WNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVING-GVP 171 WN+P + A+AAGNSVVLKPSE S A +A + + ++ V+ G G P Sbjct: 175 WNFPILMAAWKFGPALAAGNSVVLKPSEKSPLTAIRVAQLAFEAGIPAGVFNVVPGAGEP 234 Query: 172 ETTELLKERFDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNC-DLDVAC 229 L D I +TGST VGK+IM AA+ +L LELGGKSP V +C DLD A Sbjct: 235 GKLLALHRDVDCIAFTGSTAVGKLIMQYAAQSNLKRAWLELGGKSPNIVLPDCPDLDRAA 294 Query: 230 RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISA 288 + A F N G+ C A +L I++ +EKL + + + G S G I+ Sbjct: 295 QTAAGAIFYNMGEMCTAGSRLLVHRDIKDAFIEKLVAAARAYVPGNPLDPSVSMGAIVDG 354 Query: 289 RHFQRVMGLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLP 341 +RV+G I EG+ V G +A T Y+ PT+ +V P + + +EEIFGPVL Sbjct: 355 IQLERVLGYIEAGRGEGRLVTGGARVNAETGGFYVEPTVF-EVKPDAKIAREEIFGPVLS 413 Query: 342 IVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLP 401 ++ ++EA++ N E LA +++SN + +G V N ++ P Sbjct: 414 VIVFDDVDEAVRIANDTEYGLAAAVWTSNLTTAHDVSRRLRAGTVWVNCYDEGGDMN-FP 472 Query: 402 FGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 FGG SG G + E ++ +S L+R Sbjct: 473 FGGYKQSGNGRDKSLHALEKYTELKSTLIR 502 >3B4W-A nrPDB Length = 495 Score = 147 bits (372), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 110/343 (32%), Positives = 171/343 (49%), Gaps = 16/343 (4%) Query: 100 IHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-L 158 + EP+GVV I WN P L + + A+ AG ++VLKP+ + A+ LA + + L Sbjct: 142 VSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGL 201 Query: 159 DKDLYPVINGGVPETTELLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSP 216 + + V+ GG+ ET + L D +TGS+ VG+ + AA+ L P TLELGGKS Sbjct: 202 PEGVLSVVPGGI-ETGQALTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKSA 260 Query: 217 CYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGED 275 + ++ DL A + + MN+GQ CV IL S ++IV + + G Sbjct: 261 AIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPP 320 Query: 276 AKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGT---GDAATRYIAPTILTDVDPQ 327 + + G +IS + RV G I EG ++ GG G +I PT+ DVD + Sbjct: 321 SDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGRPEGLDNGFFIQPTVFADVDNK 380 Query: 328 SPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVA 387 + QEEIFGPVL I+ + E+AI N LA +++++ K+ + +G Sbjct: 381 MTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTGTYG 440 Query: 388 ANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 N + PFGG NSG+G +G + E F+ ++S L+ Sbjct: 441 IN---WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLL 480 >1AG8-A nrPDB Length = 499 Score = 147 bits (371), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 133/446 (29%), Positives = 200/446 (44%), Gaps = 24/446 (5%) Query: 2 SKISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + + AVK ARAAF G R R + L L LI+ L D K Sbjct: 56 ADVDRAVKAARAAFQLGSPWRRMDASERGRLLNRLADLIERDRTYLAALETLDNGKPYII 115 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL-YIHSEPLGVVLVIGTWNYP 117 +Y ++ VL+ + Y WA D+ KT D Y EP+GV I WN+P Sbjct: 116 SYLVDLDMVLKCLRYYAG----WA-DKYHGKTIPIDGDYFSYTRHEPVGVCGQIIPWNFP 170 Query: 118 FNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTEL 176 + + A+A GN VV+K +E + A +A +I + + VI G P Sbjct: 171 LLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNVIPGFGPTAGAA 230 Query: 177 LK--ERFDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 + E D + +TGST VG +I AA K +L VTLE+GGKSP + + D+D A + Sbjct: 231 IASHEDVDKVAFTGSTEVGHLIQVAAGKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAH 290 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQ 292 + F N GQ C A I + VE+ + ++ G + G + F+ Sbjct: 291 FALFFNQGQCCCAGSRTFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFK 350 Query: 293 RVMGLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 +V+G I EG K+ GG G AA R +I PT+ D+ + +EEIFGPV+ I+ Sbjct: 351 KVLGYIKSGKEEGLKLLCGG-GAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKF 409 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 +S+EE + N + LA +F+ + + +G V N + PFGG Sbjct: 410 KSMEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGY 467 Query: 406 GNSGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ + ++ ++ VR Sbjct: 468 KLSGSGRELGEYGLQAYTEVKTVTVR 493 >4X2Q-A nrPDB Length = 504 Score = 147 bits (370), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 123/445 (27%), Positives = 206/445 (46%), Gaps = 22/445 (4%) Query: 2 SKISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + I +AV+ AR AFS G R R + L+ L L++ L + + K Sbjct: 61 ADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQ 120 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 A+Y ++ V++ Y WA P + EP+GV I WN+P Sbjct: 121 AFYVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPL 176 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL 177 + + A+ GN+VV+KP+E + A + +I + + ++ G P + Sbjct: 177 LMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAI 236 Query: 178 KERF--DHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 D I +TGST VGK+I AA + +L VTLELGGKSP + + DLD A + Sbjct: 237 ASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQ 296 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQR 293 G F N GQ C A I + SI + V + ++++ + G + + G I + + + Sbjct: 297 GVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNK 356 Query: 294 VMGLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 ++ LI EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++ Sbjct: 357 ILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKT 416 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSL-PFGGVG 406 ++E I+ N + L +F+++ I K + +S+ + + L++ PFGG Sbjct: 417 MDEVIERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFK 473 Query: 407 NSGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ +S ++ V+ Sbjct: 474 MSGNGREMGEFGLREYSEVKTVTVK 498 >4PZ2-A nrPDB Length = 534 Score = 146 bits (369), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 131/445 (29%), Positives = 208/445 (46%), Gaps = 27/445 (6%) Query: 7 AVKRARAAFSSGRTRPLQF--RIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEV 64 AV+ ARAAF G + R + + L L++E EL + D K+ +V Sbjct: 93 AVRAARAAFDHGEWPRMSGSERGRIMARLADLVEEHAGELAALESLDAGKHPAVTRAVDV 152 Query: 65 VYVLEEIEYMIQKLPEWAADEPVEKTPQT-QQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 + Y AAD+ +T + Q + + EPLGV VI WN+P + Sbjct: 153 GNAAGSLRYFAG-----AADKIHGETLKMPGQFQGHTLREPLGVAGVIIPWNFPSTMFAV 207 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKD-LYPVINGGVPETTELLKERFD 182 + A+AAG ++V+KP+E + A LA + Q D + V+ G P L D Sbjct: 208 KVAPALAAGCALVVKPAEQTPLSALYLAQLAKQAGVPDGVINVVPGFGPTAGAALASHMD 267 Query: 183 --HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 + +TGST VG++IM A+A+ +L PV LELGGKSP V + DLD+A F N Sbjct: 268 VDMVSFTGSTEVGRLIMKASAESNLKPVYLELGGKSPLIVFDDADLDMAVELAVGASFFN 327 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGED--AKKSRDYGRIISARHFQRVMGL 297 G+ CVA + + ++ E+L + ++ + D + D G + ++RV+ Sbjct: 328 KGEACVAASRVYVQERVYDRFEERLAERMRSWVVGDPFSDPRADQGPQVDKAQYERVLSY 387 Query: 298 I-----EGQKVAYGG---TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 I EG + GG + YI PT+ T+V + +EEIFGPV+ ++ +++E Sbjct: 388 IDHGKREGATLLTGGRPCAPEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKFKTVE 447 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNS 408 EAI N L + + + V +++ +G V N + + S PFGG S Sbjct: 448 EAIARANDTRYGLGAGVVTRDLDVANRVVRSVRAGVVWVN---CYFAMGSDCPFGGRKMS 504 Query: 409 GMGSYHGKKSFETFSHRRSCLVRPL 433 G G G + + + +S +V PL Sbjct: 505 GFGKDEGMHALDKYLAVKS-VVTPL 528 >5L13-A nrPDB Length = 517 Score = 146 bits (368), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 125/443 (28%), Positives = 198/443 (44%), Gaps = 22/443 (4%) Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + +AVK ARAAF G R R + L L LI+ L D K +Y Sbjct: 76 VDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISY 135 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 ++ VL+ + Y WA + P Y EP+GV I WN+P + Sbjct: 136 LVDLDMVLKCLRY----YAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLM 191 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK- 178 + A+A GN VV+K +E + A +A +I + + ++ G P + Sbjct: 192 QAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIAS 251 Query: 179 -ERFDHILYTGSTGVGKIIMTAA-AKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 E D + +TGST +G++I AA + +L VTLELGGKSP + + D+D A + + Sbjct: 252 HEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFAL 311 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295 F N GQ C A I ++ VE+ + ++ G + G + F++++ Sbjct: 312 FFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKIL 371 Query: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 G I EG K+ GG G AA R +I PT+ DV + +EEIFGPV+ I+ +++ Sbjct: 372 GYINTGKQEGAKLLCGG-GIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTI 430 Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408 EE + N LA +F+ + + +G V N + PFGG S Sbjct: 431 EEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYKMS 488 Query: 409 GMGSYHGKKSFETFSHRRSCLVR 431 G G G+ + ++ ++ V+ Sbjct: 489 GSGRELGEYGLQAYTEVKTVTVK 511 >1BPW-A nrPDB Length = 503 Score = 144 bits (364), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 106/348 (30%), Positives = 164/348 (47%), Gaps = 19/348 (5%) Query: 99 YIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY- 157 Y EPLGV I WNYPF + A+A GN+VV KPS ++ +LA I + Sbjct: 150 YTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKPSPMTPVTGVILAEIFHEAG 209 Query: 158 LDKDLYPVINGGVPETTELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKS 215 + L V+ GG ET LL + +TGS GK +M +AK + VTLELGGKS Sbjct: 210 VPVGLVNVVQGGA-ETGSLLCHHPNVAKVSFTGSVPTGKKVMEMSAKTVKHVTLELGGKS 268 Query: 216 PCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGE 274 P + K+C+L+ A R F+ GQ C + I Q +E++ K K G+ Sbjct: 269 PLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIMPQFLEEVVKRTKAIVVGD 328 Query: 275 DAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGT----GDAATR---YIAPTILT 322 G +IS +V+G + EG +V GG D + +++P +L Sbjct: 329 PLLTETRMGGLISKPQLDKVLGFVAQAKKEGARVLCGGEPLTPSDPKLKNGYFMSPCVLD 388 Query: 323 DVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETS 382 + ++EEIFGPV+ ++ + EE +Q N LA +F+ + ++ A Sbjct: 389 NCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLASGVFTRDISRAHRVAANLE 448 Query: 383 SGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 +G N I+ +PFGG SG G +G+ + + +S ++ +V Sbjct: 449 AGTCYIN--TYSISPVEVPFGGYKMSGFGRENGQATVDYYSQLKTVIV 494 >5J77-A nrPDB Length = 508 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 95/330 (28%), Positives = 168/330 (50%), Gaps = 24/330 (7%) Query: 62 EEVVYVLEEIEYMIQKLPEWAAD---EPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 EEV V+++I+Y EWA E VE T + +++ + P G+V+ + WN+P Sbjct: 99 EEVDGVIDQIQY----YAEWARKLNGEVVEGT--SSHRKIFQYKVPYGIVVALTPWNFPA 152 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMAS-LLATIIPQYLDKDLYPVINGGVPETTELL 177 + + + A+ GN+VVLKPS + A ++ + + K + I G E + + Sbjct: 153 GMVARKLAPALLTGNTVVLKPSSDTPGSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDYI 212 Query: 178 KE--RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 235 E + + I TGST G+ IM A+ ++ + LELGGK+P V K+ D+D A + + W Sbjct: 213 VEHKKVNLITMTGSTATGQRIMQKASANMAKLILELGGKAPFMVWKDADMDNALKTLLWA 272 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295 K+ N+GQ+C+A + + I + + + + ++ D K + D G +I+ Q Sbjct: 273 KYWNAGQSCIAAERLYVHEDIYDTFMSRFVELSRKLALGDPKNA-DMGPLINKGALQATS 331 Query: 296 GLIE-----GQKVAYGGTGDAAT------RYIAPTILTDVDPQSPVMQEEIFGPVLPIVC 344 ++E G K+ +GG+ + + + PTI+ + D +S + QEEIF PV+ Sbjct: 332 EIVEEAKESGAKILFGGSQPSLSGPYRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARK 391 Query: 345 VRSLEEAIQFINQREKPLALYMFSSNDKVI 374 + S+EE N + LA Y+F+ + +I Sbjct: 392 ISSVEEMYDLANDNKYGLASYLFTKDPNII 421 >4YWE-A nrPDB Length = 487 Score = 141 bits (355), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 106/341 (31%), Positives = 164/341 (48%), Gaps = 13/341 (3%) Query: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKD 161 EP GV I WNYP + + + A+AAGN+ V+KP+E + +A + + L Sbjct: 146 EPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVVKPAEDACLSVLRVAELAAEAGLPAG 205 Query: 162 LYPVINGGVPETTELLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYV 219 ++ G E L DHI +TGS GK++ AA++ PVTLELGGKSP V Sbjct: 206 ALNIVTGYGHEAGAALARHPGIDHISFTGSPATGKLVTQMAAENHVPVTLELGGKSPQIV 265 Query: 220 DKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKS 279 + DLD A + N GQTC A +L + ++ +VE+L + ++ Sbjct: 266 FADADLDAALPVLVSAIVQNGGQTCSAGSRVLIERAVYEPLVERLATAFNGLRVGPSRAD 325 Query: 280 RDYGRIISARHFQRVMGLI-----EGQKVAYGG--TGDA--ATRYIAPTILTDVDPQSPV 330 D G +I+A+ QRV + +G +A G DA + Y AP +L DV P + Sbjct: 326 LDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQVVADAPESGFYQAPALLRDVPPSHRL 385 Query: 331 MQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAAND 390 QEE+FGPVL + +EA+ N L +++ + ++ +G V N+ Sbjct: 386 AQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAGIWTRDGARQMRLARRLRAGQVFINN 445 Query: 391 VIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 + LPFGGVG+SG G G ++ F+ ++ +R Sbjct: 446 YGAGGGV-ELPFGGVGHSGHGREKGFEALYGFTALKTIAIR 485 >4MPY-A nrPDB Length = 520 Score = 140 bits (354), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 122/439 (27%), Positives = 201/439 (45%), Gaps = 36/439 (8%) Query: 7 AVKRARAAFSSGR--TRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY--YE 62 A+ AR AF SG + R +++ A+ I+E + L D K +Y + Sbjct: 75 AILAARRAFESGEWSQETAETRGKKVRAIADKIKEHREALARLETLDTGKTLEESYADMD 134 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 ++ V + K D P+ T E I EP+GVV I WNYP Sbjct: 135 DIHNVFMYFAGLADKDGGEMIDSPIPDT------ESKIVKEPVGVVTQITPWNYPLLQAS 188 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYP-----VINGGVPETTEL 176 + A+A G S+V+KPSE++ L TI + + +++ +P +I G E ++ Sbjct: 189 WKIAPALATGCSLVMKPSEITP-----LTTIRVFELMEEVGFPKGTINLILGAGSEVGDV 243 Query: 177 LK--ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 + + D + +TG GK IM AA ++T + LELGGK+P + + D ++A + Sbjct: 244 MSGHKEVDLVSFTGGIETGKHIMKNAANNVTNIALELGGKNPNIIFDDADFELAVDQALN 303 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293 G + ++GQ C A IL SI+++ + L +K+ G + G +IS H + Sbjct: 304 GGYFHAGQVCSAGSRILVQNSIKDKFEQALIDRVKKIKLGNGFDADTEMGPVISTEHRNK 363 Query: 294 VMGLI-----EGQKVAYGGTGDAATR-----YIAPTILTDVDPQSPVMQEEIFGPVLPIV 343 + + EG +A GG + PT++T+ D ++QEE+FGPV+ + Sbjct: 364 IESYMDVAKAEGATIAVGGKRPDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVE 423 Query: 344 CVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFG 403 + +EAIQ N LA +FS + +++ + G V ND H P+G Sbjct: 424 GFETEQEAIQLANDSIYGLAGAVFSKDIGKAQRVANKLKLGTVWIND--FHPYFAQAPWG 481 Query: 404 GVGNSGMGSYHGKKSFETF 422 G SG+G GK+ E + Sbjct: 482 GYKQSGIGRELGKEGLEEY 500 >3IWJ-A nrPDB Length = 503 Score = 139 bits (350), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 122/440 (27%), Positives = 204/440 (46%), Gaps = 34/440 (7%) Query: 7 AVKRARAAFSSGR-----TRPLQFRIQQLEALQRLIQEQEQELVGALAAD----LHKNEW 57 AV A+ A + + T R + L A+ + E++ EL + D L + W Sbjct: 50 AVAAAKTALTRNKGADWATASGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPLDEAAW 109 Query: 58 NAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELY---IHSEPLGVVLVIGTW 114 + ++V E + +KL + +K P + + + + EP+GVV +I W Sbjct: 110 D--IDDVAGCFEYYADLAEKL------DARQKAPVSLPMDTFKSHVLREPIGVVGLITPW 161 Query: 115 NYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPET 173 NYP + + A+AAG + +LKPSEL+ L I + L + ++ G PE Sbjct: 162 NYPMLMATWKVAPALAAGCAAILKPSELASLTCLELGEICKEVGLPPGVLNILTGLGPEA 221 Query: 174 TELLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231 L D + +TGS+ G IMTAAA+ + PV+LELGGKSP V ++ DLD A Sbjct: 222 GAPLATHPDVDKVAFTGSSATGSKIMTAAAQLVKPVSLELGGKSPLVVFEDVDLDKAAEW 281 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDA-KKSRDYGRIISARH 290 +G F +GQ C A ++ SI + + ++ K +K D ++ G ++S Sbjct: 282 AIFGCFWTNGQICSATSRLILHESIATEFLNRIVKWIKNIKISDPLEEGCRLGPVVSEGQ 341 Query: 291 FQRVMGLI-----EGQKVAYGGTGDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPI 342 +++++ + EG + GG+ + +I PTI+TDV + +EE+FGPVL + Sbjct: 342 YEKILKFVSNAKSEGATILTGGSRPEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCV 401 Query: 343 VCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPF 402 + EEAI N L + S++ + +++ +G V N P+ Sbjct: 402 KTFSTEEEAIDLANDTVYGLGAAVISNDLERCERVTKAFKAGIVWVN--CSQPCFTQAPW 459 Query: 403 GGVGNSGMGSYHGKKSFETF 422 GGV SG G G+ + + Sbjct: 460 GGVKRSGFGRELGEWGLDNY 479 >4O6R-A nrPDB Length = 496 Score = 138 bits (347), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 111/354 (31%), Positives = 171/354 (48%), Gaps = 32/354 (9%) Query: 99 YIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQY 157 Y+ P+GVV I WN+P T M A+AAGN+VVLKPSE++ L+T+ I + Sbjct: 141 YVQRAPIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVLKPSEITP-----LSTLRIVEL 195 Query: 158 LDKDLYP--VINGGVPETTELLKERF-DH-----ILYTGSTGVGKIIMTAAAKHLTPVTL 209 + + +P V+N VP +R +H I +TGST G+ I+ A+ +L V L Sbjct: 196 MAEVGFPAGVVNI-VPGYGHTAGQRLAEHPGVGKIAFTGSTATGRRIVEASQGNLKRVQL 254 Query: 210 ELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK---LKK 266 ELGGK V + +LD A AW F N GQ C+A ++ I + +E+ L Sbjct: 255 ELGGKGANIVFDDANLDAAINGAAWAIFHNQGQACIAGSRLVLHERIADAFLERFVALAS 314 Query: 267 SLKEFYGEDAKKSRDYGRIISARHFQRVMGLIE-----GQKVAYGGTGD-----AATRYI 316 S++ G + + G + S +H RV+ ++ G +V GG+ A Y+ Sbjct: 315 SIR--IGNPLDPNTEMGPLTSKQHLDRVLSYVDVAREQGGRVLTGGSAPQDPALANGYYV 372 Query: 317 APTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKK 376 PTI+ V QEE+FGP + ++ S +EA+ N E L +++++ + Sbjct: 373 RPTIVEAKHATDRVAQEEVFGPFVTVLRFGSDDEALAIANATEYGLGSGLWTNDLSRAHR 432 Query: 377 MIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 M A +G N + S PFGGVG SG G G ++ ++ RS V Sbjct: 433 MAARIDAGMCWIN-CYKRVNPGS-PFGGVGKSGYGREMGFEAMHDYTEARSVWV 484 >3VZ3-A nrPDB Length = 457 Score = 137 bits (346), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 114/441 (25%), Positives = 199/441 (45%), Gaps = 20/441 (4%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 ++I + +A+ AF + R R Q LE +++ + + ++ K +A Sbjct: 26 AEIDAKLAKAQEAFQAYRRTSFSQRRQWLENAAAILERDTSKFAEIMTTEMGKTHQSAIA 85 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 E L Y + ++ A+E E TQ E Y+ +PLG++L + WN+PF Sbjct: 86 EAEKSALV-CRYYAEHGEQFLANEYTE----TQATESYVCYQPLGILLAVMPWNFPFWQV 140 Query: 122 IQPMVGAIAAGNSVVLK-PSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKE- 179 + A+ AGN VLK S + + ++ A + + ++ + G + +++K+ Sbjct: 141 FRFAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQTLLIGASQVEQVIKDP 200 Query: 180 RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 R TGS G + + A + + P LELGG P V + DLD A + MN Sbjct: 201 RVKAATLTGSEPAGASLASLAGQEIKPTLLELGGSDPFVVFPSADLDEAVEVGTVARTMN 260 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLK---KSLKEFYGEDAKKSRDYGRIISARHFQRV-- 294 +GQ+ +A + +I + +EKL SLK G+ D G + + Q + Sbjct: 261 NGQSAIAAKRFILHEAIAAEFLEKLHLKFASLK--IGDPMAPETDIGPLATEGILQDISR 318 Query: 295 ---MGLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350 + G K+ GG D A + PTILT++ P + ++QEE+F PV + V+ L++ Sbjct: 319 QVDQAVAAGAKILLGGRPLDRAGYFYPPTILTEIPPGAKILQEELFAPVAMVFTVKDLDQ 378 Query: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410 AI N L ++++ ++ I E +G V N ++ + LPFGG SG Sbjct: 379 AIALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGMVK--SDPRLPFGGTKRSGY 436 Query: 411 GSYHGKKSFETFSHRRSCLVR 431 G G TF + ++ ++ Sbjct: 437 GRELGLAGIRTFVNAKTVWLK 457 >4H7N-A nrPDB Length = 474 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 116/453 (25%), Positives = 214/453 (47%), Gaps = 45/453 (9%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 +++ RAR A S + ++ RI L+ ++ I + ++L AL D + Sbjct: 30 LAQQCNRARRAQSRWQELGVEGRITTLQQWKQAILSRREQLTEALVNDTGR--------- 80 Query: 64 VVYVLEEIEYMIQKLPEWAADEP-VEKTPQTQQDELYIHSE----PLGVVLVIGTWNYPF 118 + + EI+ + + W P + +T +I + P +V VI WN+P Sbjct: 81 LSITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFIALQQSLVPYPLVGVISPWNFPL 140 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSEN-MASLLATI--IPQYLDKDLYPVINGGVPETTE 175 L++ + A+ AG +VV+KPSE++ +A LL + +P+ +D+ + GG ET Sbjct: 141 TLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLMALNTVPEL--RDVLIFVEGG-GETGA 197 Query: 176 LLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 235 L D + +TGS G+ + AA+ P LELGGK P V ++ +L++A I WG Sbjct: 198 NLINYVDFVCFTGSVATGREVAETAARRFIPAYLELGGKDPAIVLESANLELATSAILWG 257 Query: 236 KFMNSGQTCVAPDYILCDPS----IQNQIVEKLKK-SLKEFYGEDAKKSRDYGRIISARH 290 +N+GQ+C++ + I S +Q++ K + L ED G II+ + Sbjct: 258 AVVNTGQSCLSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVEDGA----IGPIIAEKQ 313 Query: 291 F----QRVMGLIE-GQKVAYGGTGD--AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIV 343 ++ +E G + GG + + PT++T+V+ VM EE FGP++P++ Sbjct: 314 AGIINDHILDAVEKGAVIHCGGKVEELGGGWWCRPTVMTNVNHSMKVMTEETFGPIMPVM 373 Query: 344 CVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH----- 398 +EEA+ N L+ +F+ ++ K+ + ++G ++ ND + +H Sbjct: 374 PFPDVEEAVYLANDTIYGLSAAVFAGSEDEALKVARQLNAGAISINDAALTAMMHEGEKN 433 Query: 399 SLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 + F G+G GS G + F +++ L++ Sbjct: 434 AFNFSGLG----GSRVGAAGLKRFLRKQAFLIK 462 >3JZ4-A nrPDB Length = 481 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 106/368 (28%), Positives = 171/368 (46%), Gaps = 18/368 (4%) Query: 70 EIEYMIQKLPEWAADEPV----EKTPQTQQDE-LYIHSEPLGVVLVIGTWNYPFNLTIQP 124 EI Y + EW A+E + P Q D+ L + +P+GV I WN+P + + Sbjct: 107 EISYAASFI-EWFAEEGKRIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRK 165 Query: 125 MVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELLKER--F 181 A+AAG ++VLKP+ + A LA + I + ++ V+ G L Sbjct: 166 AGPALAAGCTMVLKPASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSNPLV 225 Query: 182 DHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSG 241 + +TGST +G+ +M AK + V+LELGG +P V + DLD A KF N+G Sbjct: 226 RKLSFTGSTEIGRQLMEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAG 285 Query: 242 QTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQRVM----- 295 QTCV + + + ++ EKL++++ + + G+ G +I + +V Sbjct: 286 QTCVCANRLYVQDGVYDRFAEKLQQAMSKLHIGDGLDNGVTIGPLIDEKAVAKVEEHIAD 345 Query: 296 GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQF 354 L +G +V GG + + PTIL DV + V +EE FGP+ P+ + + I Sbjct: 346 ALEKGARVVCGGKAHERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQ 405 Query: 355 INQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYH 414 N E LA Y ++ + + ++ G V N I I+ PFGG+ SG+G Sbjct: 406 ANDTEFGLAAYFYARDLSRVFRVGEALEYGIVGINTGI--ISNEVAPFGGIKASGLGREG 463 Query: 415 GKKSFETF 422 K E + Sbjct: 464 SKYGIEDY 471 >2D4E-A nrPDB Length = 515 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 111/350 (31%), Positives = 168/350 (48%), Gaps = 24/350 (6%) Query: 80 EWAADEPVEKTPQTQQDELYIHSE-PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLK 138 E+A ++T +D LY P G V +I WN P L+ + A+A GN+VVLK Sbjct: 137 EYAEHAMEDRTFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLK 196 Query: 139 PSELSENMASLLATIIPQY-LDKDLYPVING-GVPETTELLKERFDHIL-YTGSTGVGKI 195 P+E S A+ LA I+ + L ++ ++ G G L+ +L TG T GKI Sbjct: 197 PAEWSPFTATKLAEILKEADLPPGVFNLVQGFGEEAGAALVAHPLVPLLTLTGETETGKI 256 Query: 196 IMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPS 255 +M AA HL ++ ELGGKSP V + DL+ A + + F +G+ C A +L + Sbjct: 257 VMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEK 316 Query: 256 IQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGG-- 307 I V K+ + + G + G +I H QRV+G + EG ++ GG Sbjct: 317 IFEDFVGKVVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGER 376 Query: 308 -----TGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360 G+ +R Y+ PT+ + + QEEIFGPVL + + EEA++ N + Sbjct: 377 AKTSFRGEDLSRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVAIPFKDEEEALRKANDTKY 435 Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH-SLPFGGVGNSG 409 LA Y+F+ + + ++ E +G V N H H PFGGV SG Sbjct: 436 GLAAYVFTRDLERAHRLALELEAGMVYLNS---HNVRHLPTPFGGVKGSG 482 >6FK3-A nrPDB Length = 536 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 125/437 (28%), Positives = 195/437 (44%), Gaps = 35/437 (8%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 + +A +AR AF+ P R Q L L ++++ ++ L + ++ K E Sbjct: 58 VRKAALKAREAFAEWSRTPAPIRGQVLFNLVKILEREKPTLTRLMVREVGKTP----KEA 113 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQD-ELYIHSEPLGVVLVIGTWNYPFNLTI 122 V E I+ + E + P +D EL+ PLGVV +I N+P + Sbjct: 114 AGDVQEAIDTALFFASE-GRRLYGQTVPSEMRDKELFTFRRPLGVVGIITAGNFPIAVPS 172 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETT-----EL 176 ++ A+ GN+VV KPSE + ++ + A + + L + V+ GG +T EL Sbjct: 173 WKLIPAVLTGNTVVWKPSEDAPTLSFVFAKLFEEAGLPPGVLNVVFGGGKGSTGQWMVEL 232 Query: 177 LKER-FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 235 + E F +TGST VG+ I A ++L TLELGGK+P V ++ DLD+A W Sbjct: 233 MDEGLFQKFAFTGSTQVGRWIGEVAGRNLIRPTLELGGKNPLVVMRDADLDLAVEGAWWS 292 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSR-DYGRIISARHFQR 293 F GQ C + IL D I + + L++ G YG I+ R F R Sbjct: 293 AFATGGQRCTSAGNILVDAPIYEEFKRRFLERVEATLVGNPLLHPEVTYGPFINERFFAR 352 Query: 294 V-----MGLIEGQKVAYGGT------------GD-AATRYIAPTILTDVDPQSPVMQEEI 335 +G EG ++ +G GD A Y PT+ +V P + + EE+ Sbjct: 353 WQEHYRVGEAEGARLLFGRGRITRENPYPRFLGDPEAGLYGWPTVW-EVRPGTRLFTEEV 411 Query: 336 FGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHI 395 FGP + +V V +EEAI N L+ +++++ +G + N+ V Sbjct: 412 FGPTINLVKVDGIEEAIAVANSTPYGLSSAIYTNHRHWAYLFKVGIRAGMTSINNATVGA 471 Query: 396 TLHSLPFGGVGNSGMGS 412 H LPFGGV SG G Sbjct: 472 EAH-LPFGGVKASGNGG 487 >6C43-A nrPDB Length = 477 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 101/348 (29%), Positives = 158/348 (45%), Gaps = 24/348 (6%) Query: 100 IHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLD 159 I +P+GVV I WNYP + + A+AAGN VV+KPSE++ A LA L Sbjct: 137 IRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLAV-----LA 191 Query: 160 KDLYP-----VINGGVPETTELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELG 212 KD++P V+ G ++L E+ + TGS G+ I+ A + +ELG Sbjct: 192 KDIFPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTAPAIKRTHMELG 251 Query: 213 GKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF- 271 GK+P V + DLD + + F N+GQ C A I I + +VEKL ++ Sbjct: 252 GKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALVEKLGNAVSSLK 311 Query: 272 YGEDAKKSRDYGRIISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDV 324 G +S + G + S H +RV +E K + G + Y APT+L D Sbjct: 312 MGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEGKGYYFAPTLLADA 371 Query: 325 DPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSG 384 + ++Q E+FGPV+ I ++ +++ N LA +++ + ++ A G Sbjct: 372 KQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDVGRAHRLSARLQYG 431 Query: 385 GVAANDVIVHITLHS-LPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 N H L S +P GG SG G E ++ R +V+ Sbjct: 432 CTWIN---THFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMVK 476 >3R31-A nrPDB Length = 517 Score = 135 bits (340), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 106/350 (30%), Positives = 164/350 (46%), Gaps = 20/350 (5%) Query: 96 DELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-I 154 D Y PLGV + IG WNYP + A+ AGN++V KPSE + A +A I I Sbjct: 142 DFAYTKRVPLGVCVGIGAWNYPQQIACWKAAPALVAGNAMVFKPSENTPLGALKIAEILI 201 Query: 155 PQYLDKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELG 212 L K L+ VI G +T LL D + TGS G+ + AAA HL VT+ELG Sbjct: 202 EAGLPKGLFNVIQGDR-DTGPLLVNHPDVAKVSLTGSVPTGRKVAAAAAGHLKHVTMELG 260 Query: 213 GKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF- 271 GKSP V + D++ A G F +SGQ C + + + +E LK+ + Sbjct: 261 GKSPMIVFDDADIESAVGGAMLGNFYSSGQVCSNGTRVFVQKKAKARFLENLKRRTEAMI 320 Query: 272 YGEDAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGG------TGDAATRYIAPTI 320 G+ + G ++S ++V+ I EG + GG G+ A Y+ PT+ Sbjct: 321 LGDPLDYATHLGPLVSKAQQEKVLSYIEKGKAEGATLITGGGIPNNVAGEGA--YVQPTV 378 Query: 321 LTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAE 380 DV + +EEIFGPV+ ++ +E + N E LA +F+++ +++ Sbjct: 379 FADVTDDMTIAREEIFGPVMCVLDFDDEDEVLARANATEFGLAGGVFTADLARAHRVVDG 438 Query: 381 TSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 +G + N ++ +PFGG SG G + + E +S ++ V Sbjct: 439 LEAGTLWIN--TYNLCPVEIPFGGSKQSGFGRENSAAALEHYSELKTVYV 486 >4V6H-A nrPDB Length = 484 Score = 135 bits (339), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 107/367 (29%), Positives = 175/367 (47%), Gaps = 20/367 (5%) Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 E+ Y IE+ ++ A D TP + + + EP+GV I WN+P + Sbjct: 110 EIAYAASFIEWFAEEGKRVAGD--TLPTPDANK-RIVVVKEPIGVCAAITPWNFPAAMIA 166 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPET--TELLKE 179 + + A+AAG +V+KP+E + A +A + + + K + V+ G P+ TE+ Sbjct: 167 RKVGPALAAGCPIVVKPAESTPFSALAMAFLAERAGVPKGVLSVVIGD-PKAIGTEITSN 225 Query: 180 RFDHIL-YTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 L +TGST VG+++M +A + +TLELGG +P V + DLD A K+ Sbjct: 226 PIVRKLSFTGSTAVGRLLMAQSAPTVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYR 285 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVM-- 295 N+GQTCV + + + +KL ++ + G + G +I+ ++V Sbjct: 286 NNGQTCVCTNRFFVHERVYDAFADKLAAAVSKLKVGRGTESGATLGPLINEAAVKKVESH 345 Query: 296 ---GLIEGQKVAYGGTGDAATR-YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 L +G + GG A + PT+LT V P V +EE FGP+ P+ S EE Sbjct: 346 IADALAKGASLMTGGKRHALGHGFFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEEL 405 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM- 410 ++ N E LA Y++S + + ++ G V N + I+ PFGGV SG+ Sbjct: 406 VRLANDTEFGLAAYLYSRDIGRVWRVAEALEYGMVGINTGL--ISNEVAPFGGVKQSGLG 463 Query: 411 --GSYHG 415 GS++G Sbjct: 464 REGSHYG 470 >6MVR-A nrPDB Length = 767 Score = 134 bits (338), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 96/324 (29%), Positives = 150/324 (46%), Gaps = 5/324 (1%) Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDL 162 PLGV + WN+P + + A+A GN+VVLKP+E + A L A I Q + + Sbjct: 155 PLGVCGQVIPWNFPLLMLAWKIAPALAMGNTVVLKPAEWTPLTALLFADICGQAGVPAGV 214 Query: 163 YPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKN 222 ++ G ++ + D + +TGST VG+ I A A ++LELGGK P V + Sbjct: 215 VNIVTGDGAVGEMIVTAQVDKVAFTGSTAVGRRIREATAGTGKALSLELGGKGPYVVCDD 274 Query: 223 CDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRD 281 D+D A + + N GQ C A +L I + KL+ + G+ K D Sbjct: 275 ADIDSAVEGLVDAIWFNQGQVCCAGSRLLVQEGIADVFHAKLRARMDSLRIGDPLDKCID 334 Query: 282 YGRIISARHFQRVMGLIEGQKVA-YGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVL 340 G ++ RV ++ T A Y PT+++ + P SP+MQ+EIFGPVL Sbjct: 335 IGAMVHPDQLARVRDMVAANTDGEVYQTAVPAGCYYPPTLISGLAPASPLMQQEIFGPVL 394 Query: 341 PIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSL 400 R+ EA++ N LA ++S N + + + +G V N ++ + Sbjct: 395 VSTTFRTPAEAVEIANNTAYGLAASVWSENVNLALDLAPKLVAGIVWING--TNMMDAAA 452 Query: 401 PFGGVGNSGMGSYHGKKSFETFSH 424 PFGGV SG G G + ++ Sbjct: 453 PFGGVRESGFGREGGWEGLAGYTR 476 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 9/107 (8%) Query: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDL 162 EP+G + ++ P + M AIA GN V L SE L AT Q LD Sbjct: 631 EPVGKIGILCPDAAPLLGLVSLMAPAIAMGNRVTLAASEAFP----LAATDFYQVLDTSD 686 Query: 163 YP-----VINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHL 204 P ++ G + E + D G +G ++I A+A +L Sbjct: 687 VPAGVVNILTGAHADLAEPMARHLDLDAVWGLSGHAQVIEAASAGNL 733 >5UR2-A nrPDB Length = 984 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 93/324 (28%), Positives = 156/324 (48%), Gaps = 14/324 (4%) Query: 106 GVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMA-SLLATIIPQYLDKDLYP 164 GV VI WN+P + + A AGN+VV+KP+E S +A L+ I + + Sbjct: 633 GVTAVIAPWNFPLAILAGMVTAAAVAGNTVVMKPAEQSTVVAWGLMKMIQEAGFPQGVIN 692 Query: 165 VINGGVPETTE-LLKERFDH-ILYTGSTGVGKIIMTAAA------KHLTPVTLELGGKSP 216 + G E E ++ ++ I +TGS VG IM AA +H+ +E+GGK+ Sbjct: 693 FLPGYGEEVGEYIVNHKYTTTIAFTGSKAVGLHIMNRAAVVQPGQQHVKRCIIEMGGKNA 752 Query: 217 CYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDA 276 +D + DLD A + + F SGQ C A ++ + ++ V++L ++ K A Sbjct: 753 VIIDNDADLDEAVDGVIYSAFGFSGQKCSAASRVIVLDEVYDRFVDRLVETAKSIEIHPA 812 Query: 277 KKSRDY-GRIISARHFQRVMGLI----EGQKVAYGGTGDAATRYIAPTILTDVDPQSPVM 331 + + Y G ++ + R++G I + K+ + G+ + PTI DV + + Sbjct: 813 ENPKAYMGPVVDKEAYDRILGTIAEAEKNHKLLFKGSVPGGGFFAPPTIFGDVPGDAKLA 872 Query: 332 QEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDV 391 Q EIFGPV+ ++ ++L++A+ N E L +FS + I ++ E G + N Sbjct: 873 QAEIFGPVVAVIRAKNLDQALDIANSTEYALTGGVFSRSPANINRVKEELEVGNLYVNRG 932 Query: 392 IVHITLHSLPFGGVGNSGMGSYHG 415 I + PFGG SG+GS G Sbjct: 933 ITGAMVDRHPFGGFKMSGIGSKTG 956 >5X5U-A nrPDB Length = 505 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 112/434 (25%), Positives = 189/434 (43%), Gaps = 26/434 (5%) Query: 12 RAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEI 71 ++ F + R P R + L++E+ A+A + + + E V VL Sbjct: 80 QSGFEAWRKVPAHERAATMRKAAALVRERAD----AIAQLMTQEQGKPLTEARVEVLSAA 135 Query: 72 EYMIQKLPEWAADEPVEK-----TPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126 + + EW ADE P+ + + EP+G V WN+P N ++ + Sbjct: 136 DII-----EWFADEGRRVYGRIVPPRNLGAQQTVVKEPVGPVAAFTPWNFPVNQVVRKLS 190 Query: 127 GAIAAGNSVVLK-PSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER--FDH 183 A+A G S ++K P E + A+LL + + + ++ G E + L Sbjct: 191 AALATGCSFLVKAPEETPASPAALLRAFVDAGVPAGVIGLVYGDPAEISSYLIPHPVIRK 250 Query: 184 ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQT 243 + +TGST VGK + + A H+ T+ELGG +P V ++ D+ +A + KF N+GQ Sbjct: 251 VTFTGSTPVGKQLASLAGLHMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQV 310 Query: 244 CVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE--- 299 C++P L SI+++ L K + G ++ G + + R + +I+ Sbjct: 311 CISPTRFLVHNSIRDEFTRALVKHAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNAR 370 Query: 300 --GQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFIN 356 G + GG + + APT++ +V + V E FGPV I LEEAI N Sbjct: 371 KVGASIETGGERIGSEGNFFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEAN 430 Query: 357 QREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGK 416 + LA Y F+ + + + G + N +PFGGV +SG GS G Sbjct: 431 RLPFGLAGYAFTRSFANVHLLTQRLEVGMLWINQPAT--PWPEMPFGGVKDSGYGSEGGP 488 Query: 417 KSFETFSHRRSCLV 430 ++ E + +S V Sbjct: 489 EALEPYLVTKSVTV 502 >2J5N-A nrPDB Length = 516 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 114/419 (27%), Positives = 189/419 (45%), Gaps = 25/419 (5%) Query: 15 FSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYM 74 F + + P + R + L L++ +++EL L ++ KN W +V ++ IEY Sbjct: 87 FKTWKDWPQEDRSRLLLKAAALMRRRKRELEATLVYEVGKN-WVEASADVAEAIDFIEYY 145 Query: 75 IQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNS 134 + + VE P +D + PLG +VI WN+P + +VG +A GN+ Sbjct: 146 ARAALRYRYP-AVEVVPYPGEDNESFYV-PLGAGVVIAPWNFPVAIFTGMIVGPVAVGNT 203 Query: 135 VVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVP----ETTELLKE--RFDHILYTG 188 V+ KP+E + + A + + + P + +P E L E R I +TG Sbjct: 204 VIAKPAE---DAVVVGAKVFEIFHEAGFPPGVVNFLPGVGEEVGAYLVEHPRIRFINFTG 260 Query: 189 STGVGKIIMTAAAKHLTP-------VTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSG 241 S VG I AA + L P +E GGK VD+ D D+A + + G Sbjct: 261 SLEVGLKIYEAAGR-LAPGQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQG 319 Query: 242 QTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIE-- 299 Q C A ++ ++E++ K + A+++ D G ++SA ++V+ IE Sbjct: 320 QKCSAASRLILTQGAYEPVLERVLKRAERLSVGPAEENPDLGPVVSAEQERKVLSYIEIG 379 Query: 300 ---GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFIN 356 GQ V G + +IAPT+ T+V P++ + QEEIFGPVL ++ V+ EA++ N Sbjct: 380 KNEGQLVLGGKRLEGEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVAN 439 Query: 357 QREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHG 415 L ++S + ++ E G + N I + PFGG SG + G Sbjct: 440 DTPYGLTGGVYSRKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKTG 498 >6B4R-B nrPDB Length = 497 Score = 131 bits (329), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 125/449 (27%), Positives = 204/449 (45%), Gaps = 26/449 (5%) Query: 1 MSKISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEW 57 ++ +AVK AR AF SG R P + R Q + L+ E +EL D+ K Sbjct: 56 LADAEQAVKVARNAFDSGAWSRLAPAK-RKQTMIRFADLLLENAEELALLETLDMGKPIS 114 Query: 58 NAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL-YIHSEPLGVVLVIGTWNY 116 ++ + +V + + + A D+ ++ T EL + EP+GVV I WN+ Sbjct: 115 DSLHIDVASAANSLRWSAE-----AIDKIYDEVAATPHAELGLVTREPVGVVAAIVPWNF 169 Query: 117 PFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVING-GVPETT 174 P ++ + A+A GNSV+LKPSE S A +A + + + K ++ V+ G G Sbjct: 170 PLLMSCWKLGPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKGVFNVLPGYGHTVGK 229 Query: 175 EL-LKERFDHILYTGSTGVGKIIMT-AAAKHLTPVTLELGGKSPCYVDKNC-DLDVACRR 231 L L D +++TGST + K +M A ++ V LE GGKSP V + DL A Sbjct: 230 ALALHMDVDTLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNIVFADAPDLKAAAEA 289 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARH 290 A N G+ C A +L + SI+++ + + ++LK + G + G ++ + Sbjct: 290 AAGAIAFNQGEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPLDPETNVGALVDTQQ 349 Query: 291 FQRVMGLIE-----GQKVAYGGTG---DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI 342 V+ IE G K+ GG + Y+ PTI V + +EEIFGPVL + Sbjct: 350 MNTVLSYIEAGHNDGAKLVAGGKRTLEETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSV 409 Query: 343 VCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPF 402 + EEA++ N LA +++SN +G V N + PF Sbjct: 410 IEFEDAEEAVRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWVNQ--YDGGDMTAPF 467 Query: 403 GGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 GG SG G +F+ ++ ++ ++ Sbjct: 468 GGFKQSGNGRDKSLHAFDKYTELKATWIK 496 >5KLK-A nrPDB Length = 520 Score = 131 bits (329), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 122/439 (27%), Positives = 199/439 (45%), Gaps = 21/439 (4%) Query: 3 KISEAVKRARAAFSSGRTR-PLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 +++EAV A+ A + +Q R + + IQ + +E V A AD + A Sbjct: 76 QVNEAVVAAQNALKGPWGKLSVQDRAALIHKIADGIQARFEEFVAAEVADTGRPVHQART 135 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL-YIHSEPLGVVLVIGTWNYPFNL 120 ++ + L + + + E + L Y +PLGV+ VI W+ P L Sbjct: 136 LDIPRAIANFR-TFADLAKTSHTDLFEMSTSDGSGALNYTVRKPLGVIGVISPWDLPLLL 194 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVING-GVPETTELLK 178 + A+A GN+VV KPSE S + A+LLA ++ + ++ +I+G G E L Sbjct: 195 FTWKVAPALACGNTVVAKPSEESPSSATLLAEVMHDAGVPPGVFNLIHGFGKDSAGEFLT 254 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 + + +TG + G IM A A + V+ ELGGK+ V + DLD A + Sbjct: 255 QHPGISALTFTGESKTGSTIMKAVADGVKEVSFELGGKNAAVVFADADLDAAIEGVLRSS 314 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLK-KSLKEFYGEDAKKSRDYGRIISARHFQRV- 294 F NSGQ C+ + + SI ++ V LK ++ + G + + G +IS H +V Sbjct: 315 FTNSGQVCLCSERVYVHRSIFDEFVSGLKVEAERLVVGYPDQDGVNMGPLISHGHRDKVL 374 Query: 295 ----MGLIEGQKVAYGGT----GDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVC 344 + + EG V GG D + Y+ PTI T + ++ + EEIFGPV I Sbjct: 375 SYYRLAVDEGATVVTGGGVPKFNDERDQGAYVQPTIWTGLSDKARCVTEEIFGPVCHISP 434 Query: 345 VRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGG 404 +E I +N LA ++++N ++ + G V N ++ PFGG Sbjct: 435 FDDEDEVINRVNDSNYGLACAIWTTNLSRAHRVSRQIHVGLVWVN--TWYLRDLRTPFGG 492 Query: 405 VGNSGMGSYHGKKSFETFS 423 V SG+G G+ S + +S Sbjct: 493 VKLSGLGREGGRFSMDFYS 511 >4DNG-A nrPDB Length = 485 Score = 131 bits (329), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 97/335 (28%), Positives = 163/335 (48%), Gaps = 15/335 (4%) Query: 100 IHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLD 159 I+ PLGV+ I +N+P NL+++ + AIA GNSVV KP ++ ++ TII + + Sbjct: 139 IYRLPLGVISSISPFNFPMNLSMRSIAPAIALGNSVVHKP-DIQTAISG--GTIIAKAFE 195 Query: 160 KDLYP--VINGGVPETTELLKERFDH-----ILYTGSTGVGKIIMTAAAKHLTPVTLELG 212 P V+N + + E+ + I +TGST VG+ I A + + LELG Sbjct: 196 HAGLPAGVLNVMLTDVKEIGDGMLTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELG 255 Query: 213 GKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF- 271 G +P V + D+D A +GKF++ GQ C+ + I+ + ++ VEK +K+ Sbjct: 256 GNNPFAVLSDADVDRAVDAAIFGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLP 315 Query: 272 YGEDAKKSRDYGRIISARHFQRVMGLIEGQK---VAYGGTGDAATRYIAPTILTDVDPQS 328 YG+ G +I+ R ++ + +IE K + G + P + D S Sbjct: 316 YGDQTDPKTVVGPLINERQIEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNS 375 Query: 329 PVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAA 388 + Q E+F P+ I+ S +EAI N E L+ +F+S+ + +K + SG Sbjct: 376 KIAQTELFAPIATIIKAGSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHV 435 Query: 389 NDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFS 423 ND V+ + ++ FGG SG+G + E F+ Sbjct: 436 NDQSVNDS-PNIAFGGNKASGVGRFGNPWVVEEFT 469 >4QYJ-A nrPDB Length = 516 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 98/339 (28%), Positives = 167/339 (49%), Gaps = 14/339 (4%) Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDL 162 P+GVV I WN+P + + + A+A GN+VVLKP+E + A LA + + L Sbjct: 178 PVGVVAAIIPWNFPLLMAVWKIAPALACGNTVVLKPAEETPLTALRLAELAMEAGLPAGA 237 Query: 163 YPVING-GVPETTELLKE-RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVD 220 V+ G G L++ + + +TGST VG+II +A + L V+LELGGKSP V Sbjct: 238 LNVVTGRGETAGDALVRHPKVAKVAFTGSTEVGRIIGSACGRSLKAVSLELGGKSPVIVL 297 Query: 221 KNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKS 279 +CD A A F N GQ C A + SI ++++L + G ++ Sbjct: 298 ADCDPQEAAEGAAAAIFFNHGQVCTAGSRLYVHESIYEDVIQRLAVIGESIVVGSGLEQG 357 Query: 280 RDYGRIISARHFQRVM-----GLIEGQKVAYGGTGDAATR--YIAPTILTDVDPQS-PVM 331 G ++S +H + V+ G+ +G + GGT + ++ PTI + + + ++ Sbjct: 358 VHMGPMVSKKHHENVLRHIRNGIEDGADLICGGTEAPCAQGFFVKPTIFANREKKDIRLL 417 Query: 332 QEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDV 391 +E+FGPVL + E + N+ L +++++ ++ E +G V N Sbjct: 418 SQEVFGPVLVATPFSDIAEVVNEANRSVYGLGASIWTNDLSAALRINDELEAGTVWVN-- 475 Query: 392 IVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 ++ +LPFGG +SG+G HG + E ++ RS ++ Sbjct: 476 THNMVDPNLPFGGFKDSGVGREHGAAAIEHYTTTRSLVI 514 >4F3X-A nrPDB Length = 498 Score = 129 bits (323), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 97/342 (28%), Positives = 155/342 (45%), Gaps = 14/342 (4%) Query: 100 IHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLD 159 I +P+G+V I WNYP + + AI GN+VV KPSE + A LA +I L Sbjct: 157 IRRDPIGIVGSIAPWNYPLMMMAWKLAPAIGGGNTVVFKPSEQTPLTALKLARLIADILP 216 Query: 160 KDLYPVING-GVPETTELLKE-RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPC 217 + + VI G G L+ + + TG GK ++ AAAK + LELGGK+P Sbjct: 217 EGVVNVITGRGETVGNALINHPKVGMVSITGDIATGKKVLAAAAKTVKRTHLELGGKAPV 276 Query: 218 YVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDA 276 V + DL+ I + N+GQ C A I + I ++V L ++ Y D Sbjct: 277 IVYGDADLEAVVNGIRTFGYYNAGQDCTAACRIYAEAGIYEKLVADLTSAVSTIRYNLDD 336 Query: 277 KKSRDYGRIISARHFQRVMGLIE---GQK---VAYGG-TGDAATRYIAPTILTDVDPQSP 329 + G +IS R RV +E QK + GG TG + PT++ + Sbjct: 337 DTENEIGPLISRRQRDRVASFVERAADQKHIEITTGGRTGSDEGFFFQPTVVAGATQEDE 396 Query: 330 VMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAAN 389 +++ E+FGPV+ + ++A+ + N + LA +++ K I K + S Sbjct: 397 IVRREVFGPVVSVTRFTGKDDAVAWANDSDYGLASSVWT---KDISKAMRAASRLQYGCT 453 Query: 390 DVIVHITL-HSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 + H L + +P GG+ SG G + E ++ R ++ Sbjct: 454 WINTHFMLTNEMPHGGIKQSGYGKDMSVYALEDYTAVRHIMI 495 >3PRL-A nrPDB Length = 505 Score = 128 bits (322), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 122/445 (27%), Positives = 199/445 (44%), Gaps = 30/445 (6%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 ++++A++ A+ A + RP+ R+ L A L++E+ +E++G L + Sbjct: 50 EVNDAIQGAKDAQKIWKIRPIHERVDLLYAWADLLEER-KEIIGELIMHEVAKPKKSAIG 108 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELY----------IHSEPLGVVLVIG 112 EV + I + ADE + +T + + + + EPLGVVL I Sbjct: 109 EVSRTADIIRH--------TADEALRLNGETLKGDQFKGGSSKKIALVEREPLGVVLAIS 160 Query: 113 TWNYPFNLTIQPMVGAIAAGNSVVLKP-SELSENMASLLATIIPQYLDKDLYPVINGGVP 171 +NYP NL + A+ GN+VV KP ++ S + ++ + + + V+ G Sbjct: 161 PFNYPVNLAAAKIAPALVTGNTVVFKPATQGSLSGIKMVEALADAGAPEGIIQVVTGRGS 220 Query: 172 ETTELLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVAC 229 + L E D I +TG T G+ I A + PV LELGGK P V + DL + Sbjct: 221 VIGDHLVEHPGIDMITFTGGTTTGERISEKA--KMIPVVLELGGKDPAIVLDDADLKLTA 278 Query: 230 RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISAR 289 +I G F SGQ C A + S+ +Q+V +K+ +++ + D +I + Sbjct: 279 SQIVSGAFSYSGQRCTAIKRVFVQDSVADQLVANIKELVEQLTVGSPEDDADITPVIDEK 338 Query: 290 HFQRVMGLIEGQKVAYGGTGDAATR----YIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 + GLI+ + G T + + ++PT+L DV P V EE FGPVLPI+ V Sbjct: 339 SAAFIQGLID-DALENGATLLSGNKRQGNLLSPTLLDDVTPAMRVAWEEPFGPVLPIIRV 397 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 + EAI NQ + L +F+ + + G V N H PF GV Sbjct: 398 KDANEAISLSNQSDYGLQASIFTKDTDRAINIGKHLEVGTVHINAKTERGPDH-FPFLGV 456 Query: 406 GNSGMGSYHGKKSFETFSHRRSCLV 430 SG+G K S + + R ++ Sbjct: 457 KKSGLGVQGIKPSLLSMTRERVTVL 481 >5VBF-A nrPDB Length = 478 Score = 127 bits (319), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 107/377 (28%), Positives = 180/377 (47%), Gaps = 29/377 (7%) Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 EVV E++E+ ++ ++P Q L EP+GV WN+PF+ + Sbjct: 104 EVVSAAEQLEWHAEEGRRTYGRVVPARSPDVMQTVL---REPIGVCAAFSPWNFPFSQAM 160 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPV---INGGVP-ETTELLK 178 + A+A+G ++VLK E S + LA + + D L P I GVP + ++ L Sbjct: 161 HKIAAALASGCTLVLKGPEESPSAIVALAQL---FHDAGLPPGCLNIVWGVPGDVSKQLI 217 Query: 179 E--RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 E + I +TGS VGK + AA + +T+ELGG +P V + D++ A +A K Sbjct: 218 EAPQVRKISFTGSVPVGKQLAALAASLMKRMTMELGGHAPVLVCADADVERAAAMLAAYK 277 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKK---SLKEFYGEDAKKSRDYGRIISARHFQR 293 F N+GQ CV+P + ++ V +++ YG DA + G + AR Sbjct: 278 FRNAGQVCVSPTRFFVQRAAFDRFVCAYLDAVGTIRVGYGLDAGVT--MGPLAHARRVDE 335 Query: 294 VMGLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 + + +G ++A GG Y APT++ + +M +E FGP++ IV Sbjct: 336 IDAFVADATAKGAQIATGGMRLPGPGHYFAPTVVLGPTRDTRLMNDEPFGPIVGIVPFDD 395 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITL--HSLPFGGV 405 L++A+ N+ LA Y F+++ + ++ +G V N H + +PFGGV Sbjct: 396 LDDALAEANRLPFGLASYAFTTSARNAHRISRALEAGMVNIN----HFGMGPAEIPFGGV 451 Query: 406 GNSGMGSYHGKKSFETF 422 +SG GS G ++F+ + Sbjct: 452 KDSGFGSEGGMEAFDGY 468 >2QE0-A nrPDB Length = 475 Score = 125 bits (313), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 113/399 (28%), Positives = 176/399 (44%), Gaps = 13/399 (3%) Query: 40 QEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQK--LPEWAADEPVEKTPQTQQDE 97 +++E +GA+ + + + EVV E I Y ++ E E +++ Sbjct: 77 RDKEKIGAILSKEVAKGYKSAVSEVVRTAEIINYAAEEGLRMEGEVLEGGSFEAASKKKI 136 Query: 98 LYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY 157 + EP+G+VL I +NYP NL + A+ AGN + KP LLA + Sbjct: 137 AVVRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEA 196 Query: 158 -LDKDLYPVINGGVPETTELLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGK 214 L ++ I G E + + E + I +TGSTG+G+ I A + P+ L LGGK Sbjct: 197 GLPAGVFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIGKMAG--MRPIMLALGGK 254 Query: 215 SPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGE 274 V ++ DL++ + I G F SGQ C A +L S+ +++VEK+++ + Sbjct: 255 DSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVADELVEKIREKVLALTIG 314 Query: 275 DAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATR----YIAPTILTDVDPQSPV 330 + + D +I + V GLI G T + I P + V + Sbjct: 315 NPEDDADITPLIDTKSADYVEGLINDAN-DKGATALTEIKREGNLICPILFDKVTTDMRL 373 Query: 331 MQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAAND 390 EE FGPVLPI+ V S+EEAI+ N+ E L +F +ND IAE G + Sbjct: 374 AWEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQASIF-TNDFPRAFGIAEQLEVGTVHIN 432 Query: 391 VIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCL 429 + PF G SG G K S E + +S + Sbjct: 433 NKTQRGTDNFPFLGAKKSGAGIQGVKYSIEAMTTVKSVV 471 >3VZ0-A nrPDB Length = 459 Score = 125 bits (313), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 110/386 (28%), Positives = 174/386 (45%), Gaps = 36/386 (9%) Query: 68 LEEIEYMIQKLPEWA--ADEPVEKTP-QTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQP 124 LEEI+ L +A A+E + TP + + + I ++PLG++ I WN+P+ + Sbjct: 86 LEEIDVTADILSFYANGAEEFLAPTPLKVKTGQAKIINQPLGIIYCIEPWNFPYYQLARV 145 Query: 125 MVGAIAAGNSVVLKPS-----------ELSENMASLLATIIPQYLDKDLYPVINGGVPET 173 + AGN V+ K + +L + + + +LD D ++ Sbjct: 146 AGPNLMAGNVVIAKHAPNVPQCALAFEKLFHDAGAPVGAYANIFLDND----------QS 195 Query: 174 TELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRI 232 EL+K ER + TGS G+ + A L T+ELGG V + DLD+A + Sbjct: 196 AELIKDERIRGVALTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVLDDADLDLAVKWA 255 Query: 233 AWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHF 291 WG+F N+GQ C A ++ + + ++ LK ++ F G + +G + S R Sbjct: 256 VWGRFANNGQVCTAAKRMIVHEKVYDAFLDGLKTAITRFRIGNPLDRDTTHGPMSSLRAM 315 Query: 292 QRVMG----LIEGQK--VAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 + + ++G VA G D ++ PTILTDV +PV +EIFGPV + V Sbjct: 316 ELALDQTAEAVKGGATLVAGGKRMDRKGFFMEPTILTDVSKDNPVFYQEIFGPVAVVHKV 375 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 S + AI N L +FS + +K+ + +G V N LPFGG+ Sbjct: 376 ASEQAAIDLANDSPYGLGGAVFSRDIARAEKVAEQVETGMVFINTATA--AAPELPFGGI 433 Query: 406 GNSGMGSYHGKKSFETFSHRRSCLVR 431 NSG G E F +R+ LVR Sbjct: 434 KNSGFGRELSFLGIEEFINRK--LVR 457 >5KF0-A nrPDB Length = 485 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 102/358 (28%), Positives = 169/358 (47%), Gaps = 21/358 (5%) Query: 87 VEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENM 146 +E + + Q Y P+G I +N+P NL + A+AAG VLKP+ + Sbjct: 134 LEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVG 193 Query: 147 ASLLATIIPQY-LDKDLYPVI----NGGVPETTELLKERFDHILYTGSTGVGKIIMTAAA 201 A ++A ++ + L K + V+ +G TT+ ERF + +TGS VG + A Sbjct: 194 ALIIAEVLAETNLPKGAFSVLPAHRDGADLFTTD---ERFRLLSFTGSPAVGWALKEKAG 250 Query: 202 KHLTPVTLELGGKSPCYVDKNC--DLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ 259 K V LELGG + VD + LD R+A+G + SGQ+C+ IL S+ + Sbjct: 251 KK--KVVLELGGNAAAIVDADQFEQLDYVVDRLAFGAYYQSGQSCIGVQRILVHASLYDT 308 Query: 260 IVEKLKKSLKEFYGEDAKKSRDY-GRIISARHFQRVMGLIE-----GQKVAYGGTGDAAT 313 + +KL + D K + G +IS +R+ G ++ G K+ GG D A Sbjct: 309 LRDKLVAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIIAGGKVDGAM 368 Query: 314 RYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKV 373 T+L DV + + ++E FGPV + ++A+ +N + L +F+ + Sbjct: 369 --FEATLLEDVGREQDLYRKEAFGPVAILEKFDRFDDALARVNDSDFGLQAGVFTDSLTH 426 Query: 374 IKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 ++ E GGV NDV + ++P+GGV +SG+G + + E + R +VR Sbjct: 427 AQRAWDELEVGGVVINDV-PSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLMVVR 483 >3RH9-A nrPDB Length = 506 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 115/435 (26%), Positives = 198/435 (45%), Gaps = 27/435 (6%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 + AV+ ++A P++ R + LE ++ ++E +E +G + H W E Sbjct: 51 VVAAVEAGQSALRLTNPWPIETRRKWLEDIRDGLKENREE-IGRILCMEHGKPWKEAQGE 109 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELY-IHSEPLGVVLVIGTWNYPFNLTI 122 V Y +Y + + A D P+ +D + +H P+GV +I WN+P + Sbjct: 110 VDYAAGFFDYCAKHIS--ALDS--HTIPEKPKDCTWTVHYRPVGVTGLIVPWNFPIGMIA 165 Query: 123 QPMVGAIAAGNSVVLKP-SELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERF 181 + + A+AAG V+KP SE M + + + L + ++ G ++L E Sbjct: 166 KKLSAALAAGCPSVIKPASETPLTMIAFFSVMDKLDLPDGMVNLVMGKASVIGKVLCEHK 225 Query: 182 D--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 D + +TGST VG+ ++ A+ + + LELGG +P V + DL+ A + KF Sbjct: 226 DVPMLSFTGSTEVGRKLIVDTAEQVKKLALELGGNAPFIVFDDADLEAAADNLIANKFRG 285 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRV---- 294 GQTCV + I + + +KL + + + G+ D G +I+ + F +V Sbjct: 286 GGQTCVCANRIFVHEKVADAFGQKLAERVNKMTVGDGMNDGIDIGPLINKQGFDKVKRHL 345 Query: 295 -------MGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 L+ G++ A G G + PT++ VD + QEE FGP++P+ R+ Sbjct: 346 QDALDKGASLVAGKQPAELGDG----LFFPPTVVQGVDREMCCYQEETFGPLVPMALFRT 401 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 EE I N E LA Y+F+++ + +++ A G V N PFGG+ Sbjct: 402 EEEVIDAGNDTEFGLASYVFTADAERAQRVAAGLRFGHVGWNTGTGPTP--EAPFGGMKA 459 Query: 408 SGMGSYHGKKSFETF 422 SG+G G + F Sbjct: 460 SGIGREGGLEGLFEF 474 >4U3W-A nrPDB Length = 505 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 129/448 (28%), Positives = 196/448 (43%), Gaps = 25/448 (5%) Query: 4 ISEAVKRARAAFSSG--RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + AV+ A AA +G T P Q R L + I+ + E V A AD + A Sbjct: 61 VDSAVQAAHAAQKAGWRDTTPAQ-RAAWLHKIADGIEARFDEFVAAEVADTGRPVAQART 119 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL--YIHSEPLGVVLVIGTWNYPFN 119 ++ + L A+ E E T EL Y+ +PLGV+ +I WN P Sbjct: 120 LDIARGIANFR-TFADLVRTASGEYFE-THAADGSELINYVTRKPLGVIGIISPWNLPLL 177 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVING-GVPETTELL 177 L + A+A GN VV KPSE + + A+LLA ++ L ++ +I+G G E L Sbjct: 178 LFTWKVAPALAMGNCVVAKPSEETPSSATLLAEVMHDVGLPPGVFNLIHGHGQNAAGEFL 237 Query: 178 KERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 235 D I +TG + G IM A A + V+ ELGGK+ V + D D A + Sbjct: 238 TRHPDISAITFTGESRTGSTIMKAVADGVKEVSFELGGKNAAVVFADADFDAAVAGVLRS 297 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRV 294 F N+GQ C+ + + + I + V LK+ + G + G +IS H +V Sbjct: 298 SFTNAGQVCLCSERVYVERPIFERFVAALKEQAQALRVGAPEDPATTMGPLISRGHRDKV 357 Query: 295 MGLI-----EGQKVAYGGT----GDAAT--RYIAPTILTDVDPQSPVMQEEIFGPVLPIV 343 + EG V GG GDA ++ PTI T + + ++EEIFGPV I Sbjct: 358 LSYFRLAVEEGATVVTGGGAPSFGDARDDGAFVMPTIWTGLPDSARCVREEIFGPVCHIA 417 Query: 344 CVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFG 403 E ++ +N LA ++++ ++ + +G V N V PFG Sbjct: 418 PFDDEAEVVKRVNDSAYGLAASIWTTQLARGHRVAKQIETGIVWVNAWFVRDL--RTPFG 475 Query: 404 GVGNSGMGSYHGKKSFETFSHRRSCLVR 431 G SG+G G+ S + +S + VR Sbjct: 476 GTKLSGLGREGGRHSLDFYSELTNVCVR 503 >3JU8-A nrPDB Length = 490 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 115/424 (27%), Positives = 187/424 (44%), Gaps = 27/424 (6%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 +++ AV AR AF + RPL+ RI+ LE ++ + EL + + K W + Sbjct: 42 TQVDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESA- 100 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 EV ++ ++ +Q E EK+ + +P GVV V G +N+P +L Sbjct: 101 TEVTSMVNKVAISVQAFRERTG----EKSGPLADATAVLRHKPHGVVAVFGPYNFPGHLP 156 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASL-LATIIPQYLDKDLYPVINGGVPETTELLKER 180 +V A+ AGN VV KPSEL+ +A L L I L + ++ GG L R Sbjct: 157 NGHIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQGGRETGVALAAHR 216 Query: 181 -FDHILYTGSTGVGKIIMTAAAKHLTPV-TLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 D + +TGS+ G ++ + + LE+GG +P V++ DLD A I F+ Sbjct: 217 GLDGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFI 276 Query: 239 NSGQTCVAPDYILC------DPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIIS---AR 289 ++GQ C +L D + + + F D + + G +IS A Sbjct: 277 SAGQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRF---DEQPAPFMGAVISLSAAE 333 Query: 290 HFQRVMGLIEGQK----VAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 H + + G+ +A D A + P IL DV + EE FGP+L ++ Sbjct: 334 HLLKAQEHLIGKGAQPLLAMTQPIDGAA-LLTPGIL-DVSAVAERPDEEFFGPLLQVIRY 391 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 AI+ N + LA + S + + ++ + E+ +G V N + S PFGG+ Sbjct: 392 SDFAAAIREANATQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTGAA-SSAPFGGI 450 Query: 406 GNSG 409 G SG Sbjct: 451 GASG 454 >5IUV-A nrPDB Length = 497 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 119/445 (26%), Positives = 202/445 (45%), Gaps = 30/445 (6%) Query: 7 AVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 AV+ AR+AF SG R P + + + L+++ +EL D+ K ++ + Sbjct: 62 AVESARSAFDSGAWSRLAPAKRKATMIR-FAGLLEQNAEELALLETLDMGKPISDSLGVD 120 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL-YIHSEPLGVVLVIGTWNYPFNLTI 122 + + + + A D+ ++ T D+L + EP+GVV I WN+P + Sbjct: 121 IPGGARALSWSGE-----AIDKLYDEVAATPHDQLGLVTREPVGVVAAIVPWNFPLMMAC 175 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATI-----IPQYLDKDLYPVINGGVPETTELL 177 + A++ GNSVVLKPSE S A +A + IP + ++ P V + L Sbjct: 176 WKLGPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAGV-LNVLPGYGHTVGKALALH 234 Query: 178 KERFDHILYTGSTGVGKIIMT-AAAKHLTPVTLELGGKSPCYVDKNC-DLDVACRRIAWG 235 + D +++TGST + K +M A ++ V LE GGKSP V + DL A A Sbjct: 235 MD-VDTVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASA 293 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQRV 294 N G+ C A +L + SI+++ + + ++L + G + + G ++ + V Sbjct: 294 IAFNQGEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTV 353 Query: 295 M-----GLIEGQKVAYGGT---GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346 + G +G ++ GG + Y+ PTI V+ + QEEIFGPVL ++ Sbjct: 354 LSYIAAGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFD 413 Query: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406 + EEAIQ N LA ++++N +G V N + PFGG Sbjct: 414 TAEEAIQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWVNQ--YDGGDMTAPFGGFK 471 Query: 407 NSGMGSYHGKKSFETFSHRRSCLVR 431 SG G +F+ ++ +S ++ Sbjct: 472 QSGNGRDKSLHAFDKYTELKSTWIK 496 >4JZ6-A nrPDB Length = 500 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 95/349 (27%), Positives = 155/349 (44%), Gaps = 26/349 (7%) Query: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ------ 156 +P+G +L I WN L + + + GN+VV K SE S +L+ + + Sbjct: 154 QPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEFSPATHALITQCVQEAGLPAG 213 Query: 157 ---YLDK--DLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLEL 211 YL+ D P I + E+ + I +TGST VG II AA+HL LEL Sbjct: 214 VLNYLNSSPDRSPEIADALISAKEIRR-----INFTGSTRVGSIIAQKAAQHLKRCLLEL 268 Query: 212 GGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF 271 GGKSP V + D++ A + +G F+ GQ C++ + ++ D I ++ V + + + Sbjct: 269 GGKSPLIVLDDADINAAVKAAVFGSFLFQGQICMSTERLVVDEKIADEFVARFVEKTERL 328 Query: 272 YGEDAKKSRD--YGRIISARHFQRVMGLI-----EGQKVAYGGTGDAATRYIAPTILTDV 324 D + D G ++S +R+ GL +G KV GG A + TIL V Sbjct: 329 SVGDPCLTGDCIIGPMVSPNSGERINGLFKDAIDKGAKVVCGGMAQGAV--MPATILDHV 386 Query: 325 DPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSG 384 + EE FGP+ ++ + EAI+ N L+ +F + ++ G Sbjct: 387 KSDMRIYDEETFGPITVVIRCKGEAEAIRIANDSVYGLSSGVFGRDINRALRVGMSIEYG 446 Query: 385 GVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPL 433 V N V + P+GG N+G G + G+ + F+ + + P Sbjct: 447 CVHINGSTVQNEAQA-PYGGTKNTGYGRFDGRAVIDEFTELKWLTIEPF 494 >1WNB-A nrPDB Length = 495 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 119/436 (27%), Positives = 191/436 (43%), Gaps = 40/436 (9%) Query: 18 GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMI-- 75 G+T P + R + L L +I+E Q + + K +A+ +E+ +++ + Sbjct: 77 GQTTP-KVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGA 135 Query: 76 -QKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNS 134 + L AA E +E I +PLGVV I WNYP + + A+AAGN Sbjct: 136 ARCLNGLAAGEYLEGHTSM------IRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNC 189 Query: 135 VVLKPSELSENMASLLATIIPQYLDKDLYP--VIN--------GGVPETTELLKERFDHI 184 VVLKPSE++ A LA L KD++P V+N G P T + + Sbjct: 190 VVLKPSEITPLTALKLAE-----LAKDIFPAGVVNILFGRGKTVGDPLTGH---PKVRMV 241 Query: 185 LYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTC 244 TGS G+ I++ A + +ELGGK+P V + D++ + + N+GQ C Sbjct: 242 SLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDC 301 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIEGQ-- 301 A I I + +VEKL ++ G +S + G + S H +RV +E Sbjct: 302 TAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKA 361 Query: 302 ----KVAYGGTGDAAT-RYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFIN 356 KV GG Y APT+L ++Q+E+FGPV+ + + E+ + + N Sbjct: 362 TGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWAN 421 Query: 357 QREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNSGMGSYHG 415 + LA +++ + ++ A G N H L S +P GG SG G Sbjct: 422 DSQYGLASSVWTKDVGRAHRVSARLQYGCTWVN---THFMLVSEMPHGGQKLSGYGKDMS 478 Query: 416 KKSFETFSHRRSCLVR 431 E ++ R +V+ Sbjct: 479 LYGLEDYTVVRHVMVK 494 >3RHO-A nrPDB Length = 517 Score = 122 bits (305), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 114/443 (25%), Positives = 205/443 (46%), Gaps = 29/443 (6%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58 +S + +AV A+ AF +G + R + L L ++++ ++EL A D Sbjct: 73 VSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTL 132 Query: 59 AYYEEVVYVLEEIEYMIQKLPE-WAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYP 117 A V ++ Y + A P+ + + ++ EP+GV ++ WNYP Sbjct: 133 ALKTHVGMSIQTFRYFAGWCDKIQGATIPINQA-RPNRNLTLTKKEPVGVCGIVIPWNYP 191 Query: 118 FNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177 + +AAGN+VV+KP++++ A A + L + + +P + L+ Sbjct: 192 LMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELT---LKAGIPKGVVNILPGSGSLV 248 Query: 178 KERF-DH-----ILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACR 230 +R DH I +TGST VGK IM + A ++ V+L+LGGKSP + +CDL+ A + Sbjct: 249 GQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLQLGGKSPLIIFADCDLNKAVQ 308 Query: 231 RIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISAR 289 F N G+ C+A + + SI NQ V+K+ + +++ G ++ ++G Sbjct: 309 MGMSSVFFNKGENCIAAGRLFVEESIHNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHEA 368 Query: 290 HFQRVM-----GLIEGQKVAYGGTGDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLP 341 H ++++ G+ EG + G G+ R + PT+ TDV+ + +EE FGP++ Sbjct: 369 HLRKLVEYCQRGVKEGATLVCG--GNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMI 426 Query: 342 I--VCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS 399 I ++ + N E LA +F+ + + + +G V N + T + Sbjct: 427 ISRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFIN--TYNKTDVA 484 Query: 400 LPFGGVGNSGMGSYHGKKSFETF 422 PFGG SG G G+ + + Sbjct: 485 APFGGFKQSGFGKDLGEAALNEY 507 >4I3V-A nrPDB Length = 488 Score = 122 bits (305), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 111/354 (31%), Positives = 173/354 (48%), Gaps = 25/354 (7%) Query: 90 TPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASL 149 TP + +++ EPL + I +N+P N+ + AIA N VV+KP+EL+ A L Sbjct: 136 TPHGKARKIFTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKPTELTPMTALL 195 Query: 150 LATIIPQY-LDKDLYPVINGGVPET-TELLKE-RFDHILYTGSTGVGKIIMTAAAKHLTP 206 LA I+ + L ++ V+ G + E++ D + +TGS VGK+I AA H Sbjct: 196 LADILYEAGLPPEMLSVVTGWPADIGMEMITNPHVDLVTFTGSVPVGKLI--AANAHYKR 253 Query: 207 VTLELGGKSPCYVDKNC---DLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVE- 262 LELGG P + + DL A G NSGQ C A ILC S+ ++ V Sbjct: 254 QVLELGGNDPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKRILCQESVADRFVPL 313 Query: 263 KLKKSLKEFYGEDAKKSRDYGRII----SARHFQRVM-GLIEGQKVAYGGTGDAATRYIA 317 L+++ + +G+ +S D G +I +A +RVM EG + Y A + Sbjct: 314 VLERAKRLRFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGADILYHPGRSGA--LLP 371 Query: 318 PTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA-IQFINQREKPLALYMFSSNDKVIKK 376 P ++ V QS ++ EE FGP++PIV V ++A I N L+ + +++ + ++K Sbjct: 372 PIVVDRVPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAFGLSSGVCTNDYRRMQK 431 Query: 377 MIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHG----KKSF---ETFS 423 IA G V +V + + PFGG+ +SG G G KSF +TFS Sbjct: 432 YIAGLKVGTVNIWEVPGY-RIEMSPFGGIKDSGNGYKEGVIEAMKSFTNVKTFS 484 >3EFV-A nrPDB Length = 462 Score = 121 bits (303), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 109/431 (25%), Positives = 181/431 (41%), Gaps = 23/431 (5%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 +I A+ A + F + + R Q L + + ++ +E+ + ++ K A Sbjct: 30 EIEHALSLAASGFKKWKMTSVAQRAQTLRDIGQALRAHAEEMAQCITREMGKPIKQAR-A 88 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 EV ++ + P EP + + I PLGV+L I WN+P + Sbjct: 89 EVTKSAALCDWYAEHGPAMLNPEPT----LVENQQAVIEYRPLGVILAIMPWNFPLWQVL 144 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE-R 180 + V + AGNS +LK + A ++A I+ + +Y +N ++++ + R Sbjct: 145 RGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVYGWVNANNEGVSQMINDPR 204 Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240 + TGS G I A L LELGG P V + DL++A + G++ N+ Sbjct: 205 IAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLELAVKAAVAGRYQNT 264 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISAR-------HFQ 292 GQ C A + + I ++ + G+ + D G + AR H Q Sbjct: 265 GQVCAAAKRFIVEEGIAQAFTDRFVAAAAALKMGDPLVEENDLGPM--ARFDLRDELHQQ 322 Query: 293 RVMGLIEGQKVAYGGTGDAAT-RYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 + EG ++ GG A Y A T+L DV P ++E+FGPV I + A Sbjct: 323 VQASVAEGARLLLGGEKIAGEGNYYAATVLADVTPDMTAFRQELFGPVAAITVAKDAAHA 382 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411 + N E L+ +F+++D + +M A GGV N + + FGGV SG G Sbjct: 383 LALANDSEFGLSATIFTADDTLAAEMAARLECGGVFING--YSASDARVAFGGVKKSGFG 440 Query: 412 ---SYHGKKSF 419 S+ G F Sbjct: 441 RELSHFGLHEF 451 >5U0M-A nrPDB Length = 497 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 111/431 (25%), Positives = 189/431 (43%), Gaps = 40/431 (9%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + + AV+ AR AF + R + L R +EA L++ ++EL + + K W + Sbjct: 47 LEDVDAAVREARKAFLAWRRKSLAERQAVIEAFGELLEANKEELAHQIGLETGKPLWESR 106 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHS----EPLGVVLVIGTWNY 116 E+ M+ K+P + E+T T+ D H+ P GVV V G +N+ Sbjct: 107 --------TEVAAMMGKIP-ISVKAYNERTGHTESDVAGGHAVLRHRPHGVVAVFGPYNF 157 Query: 117 PFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTE 175 P +L +V A+ AGN+VV KPSEL+ +A L + + L + ++ GG Sbjct: 158 PGHLPNGHIVPALLAGNTVVFKPSELTPGVAELTVRLWEKAGLPDGVINLVQGGSDTGKC 217 Query: 176 LLKERF-DHILYTGSTGVGKIIMTAAAKHLTPV-TLELGGKSPCYVDKNCDLDVACRRIA 233 L + D + +TGS+ VG ++ + LE+GG +P V DLD A Sbjct: 218 LARHSLIDGLFFTGSSTVGHLLHEQFGGQPEKILALEMGGNNPLIVQNVSDLDGAVHHAL 277 Query: 234 WGKFMNSGQTCVAPDYILC------DPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIIS 287 F+++GQ C +L D + + + ++ EF DA G +IS Sbjct: 278 QSAFLSAGQRCTCARRLLVPKGKKGDEFLARLVEVAARITVAEF---DADPQPFMGSVIS 334 Query: 288 ARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSP---------VMQEEIFGP 338 A +++ + + G T + + P D SP + +E FGP Sbjct: 335 AEAANQLLK-AQAAMLEKGATSLLEMKQLKP----DTGLLSPGIVDATGIELEDQEFFGP 389 Query: 339 VLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH 398 +L + + +EA++ N L+ + S + K+ +++ E +G V N + + Sbjct: 390 LLTVYRYKGFDEALELANNTRYGLSAGILSDDRKLYNRLVEEVRAGIVNWNRPLTGAS-S 448 Query: 399 SLPFGGVGNSG 409 + PFGGVG SG Sbjct: 449 AAPFGGVGASG 459 >3EK1-A nrPDB Length = 504 Score = 119 bits (297), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 104/369 (28%), Positives = 166/369 (44%), Gaps = 15/369 (4%) Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 EV+Y IE+ ++ D PQ Q L + +P+GV I WN+P + Sbjct: 130 EVLYAASFIEWFAEEAKRVYGD--TIPAPQNGQ-RLTVIRQPVGVTAAITPWNFPAAMIT 186 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL--KE 179 + A+AAG +++++P++L+ A L + + + + ++ G E L + Sbjct: 187 RKAAPALAAGCTMIVRPADLTPLTALALGVLAEKAGIPAGVLQIVTGKAREIGAELTSND 246 Query: 180 RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 + +TGST VG+++M A + ++LELGG +P V + DLD A K+ N Sbjct: 247 TVRKLSFTGSTEVGRLLMAQCAPTIKRISLELGGNAPFIVFDDADLDAAVDGAMVSKYRN 306 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298 +GQTCV + I + ++ EKL +KE G + G +I + +V I Sbjct: 307 AGQTCVCANRIYVQRGVYDKFAEKLAAKVKELKVGNGTEPGVVIGPMIEEKAITKVKAHI 366 Query: 299 E-----GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQ 353 E G K+ GG + + P ILT V V +EE FGP+ P+ + EE I Sbjct: 367 EDAVSKGAKLITGGK-ELGGLFFEPGILTGVTSDMLVAKEETFGPLAPLFAFDTEEEVIA 425 Query: 354 FINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSY 413 N LA Y ++ N ++ G V N + I+ PFGGV SG+G Sbjct: 426 QANDTIFGLAAYFYTENFSRAIRVSEALEYGMVGHNTGL--ISNEVAPFGGVKQSGLGRE 483 Query: 414 HGKKSFETF 422 K E + Sbjct: 484 GSKYGIEEY 492 >5JRY-A nrPDB Length = 485 Score = 118 bits (296), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 99/358 (27%), Positives = 166/358 (46%), Gaps = 21/358 (5%) Query: 87 VEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENM 146 +E + + Q Y P+G I +N+P NL + A+AAG VLKP+ + Sbjct: 134 LEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVG 193 Query: 147 ASLLATIIPQY-LDKDLYPVI----NGGVPETTELLKERFDHILYTGSTGVGKIIMTAAA 201 A ++ ++ + L K + V+ +G TT+ +RF + +TGS VG + A Sbjct: 194 ALIIGEVLAETDLPKGAFSVLPAHRDGADLFTTD---DRFRLLSFTGSPAVGWALKEKAG 250 Query: 202 KHLTPVTLELGGKSPCYVDKN--CDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ 259 K V LELGG + VD + LD R+A+G F SGQ+C+ IL I + Sbjct: 251 KK--KVVLELGGNAAAIVDADQLDRLDYVVDRLAFGAFYQSGQSCIGVQRILAHADIYDA 308 Query: 260 IVEKLKKSLKEFYGEDAKKSRDY-GRIISARHFQRVMGLIE-----GQKVAYGGTGDAAT 313 + +KL + D K + G +IS +R+ G ++ G K+ GG D A Sbjct: 309 LRDKLIAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIVAGGKVDGAM 368 Query: 314 RYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKV 373 T+L +V + ++E FGP+ + ++A+ +N + L +F+ + Sbjct: 369 --FEATLLENVGRDQDLYRKEAFGPIAILEKFDRFDDALARVNDSDFGLQAGVFTDSLAH 426 Query: 374 IKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 ++ E GGV NDV + ++P+GGV +SG+G + + E + R +VR Sbjct: 427 TQQAWDELEVGGVVINDV-PSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLLVVR 483 >5J6B-A nrPDB Length = 485 Score = 117 bits (294), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 100/358 (27%), Positives = 166/358 (46%), Gaps = 21/358 (5%) Query: 87 VEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENM 146 +E +P+ Q Y P+G I +N+P NL + A+AAG VLKP+ + Sbjct: 134 LEISPRAQGYSGYYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPIG 193 Query: 147 ASLLATIIPQY-LDKDLYPVI----NGGVPETTELLKERFDHILYTGSTGVGKIIMTAAA 201 A ++ ++ + L K + ++ +G TT+ ERF + +TGS VG + A Sbjct: 194 ALIIGEVLAETDLPKGAFSILPAHRDGADLFTTD---ERFKLLSFTGSPTVGWELKKKAG 250 Query: 202 KHLTPVTLELGGKSPCYVDKNCD--LDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ 259 K V LELGG + VD + LD R+A+G + SGQ+C+ I+ + + Sbjct: 251 KKK--VVLELGGNAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQRIIAHADVYDA 308 Query: 260 IVEKLKKSLKEFYGEDAKKSRDY-GRIISARHFQRVMGLIE-----GQKVAYGGTGDAAT 313 + EKL + D K + G +IS +R+ G +E G K+ GG D A Sbjct: 309 LREKLIAKTRSLKMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAKIVAGGKVDGAM 368 Query: 314 RYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKV 373 T+L V + ++E FGPV + ++A+ +N + L +F+ + Sbjct: 369 --FEATLLEGVGRDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGLQAGVFTDSLSH 426 Query: 374 IKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 ++ E GGV NDV + ++P+GGV +SG+G + + E + R +VR Sbjct: 427 AQRAWDELEVGGVVINDV-PSFRVDNMPYGGVKDSGLGREGIRYAIEDMTELRLMVVR 483 >1UXV-A nrPDB Length = 501 Score = 117 bits (293), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 96/338 (28%), Positives = 161/338 (47%), Gaps = 19/338 (5%) Query: 86 PVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSEN 145 P + T T + E + EPLGVV I +NYP + + + GN+VV+KPS +S+ Sbjct: 139 PGDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAVVVKPS-ISDP 197 Query: 146 MASLLAT--IIPQYLDKDLYPVINGGVPETTELL-KERFDHILYTGSTGVG-KIIMTAAA 201 + + +A ++ D ++N E +++ +R + +TGST VG +++ Sbjct: 198 LPAAMAVKALLDAGFPPDAIALLNLPGKEAEKIVADDRVAAVSFTGSTEVGERVVKVGGV 257 Query: 202 KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIV 261 K +ELGG P V ++ DLD+A +IA G + +GQ C A +L + + ++V Sbjct: 258 KQYV---MELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVLAERPVYGKLV 314 Query: 262 EKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTI 320 E++ K L G+ + D G +IS +M IE V GG A R + PT Sbjct: 315 EEVAKRLSSLRVGDPRDPTVDVGPLISPSAVDEMMAAIE-DAVEKGGRVLAGGRRLGPTY 373 Query: 321 LTDVDPQSP--------VMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDK 372 + ++P + + E+F PV V V+ L++AI+ N R L +F + Sbjct: 374 VQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGLDAAVFGRDVV 433 Query: 373 VIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410 I++ + G + ND+ H + PFGG SG+ Sbjct: 434 KIRRAVRLLEVGAIYINDMPRH-GIGYYPFGGRKKSGV 470 >5TJR-A nrPDB Length = 531 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 118/449 (26%), Positives = 194/449 (43%), Gaps = 31/449 (6%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 + +A+ A+AAF + R P R Q L ++L++ E+ +V L ++ H E Sbjct: 75 MQQAIDAAKAAFPAWRNTPPAKRAQVLFRFKQLLEANEERIV-KLISEEHGKTIEDAAGE 133 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 + +E +EY PE E + + +P+GVV I +N+P + + Sbjct: 134 LKRGIENVEYATAA-PEILKGEYSRNV--GPNIDAWSDFQPIGVVAGITPFNFPAMVPLW 190 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE-RF 181 AIA GN+ +LKPSE + L+A + + L K + V++G L++ Sbjct: 191 MYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGLPKGVLNVVHGDKGAVDALIEAPEV 250 Query: 182 DHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSG 241 + + GST + + I + K V G K+ + + DLD A + + + G Sbjct: 251 KALSFVGSTPIAEYIYSEGTKRGKRVQALGGAKNHAVLMPDADLDNAVSALMGAAYGSCG 310 Query: 242 QTCVAPDYILC-DPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE 299 + C+A +C I + +V+KL +K G D G +++ +V G I+ Sbjct: 311 ERCMAISVAVCVGDQIADALVQKLVPQIKGLKIGAGTSCGLDMGPLVTGAARDKVTGYID 370 Query: 300 --------------GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 G KVA G ++ T+ V P+ + +EEIFGPVL IV V Sbjct: 371 TGVAQGAELVVDGRGYKVA----GHENGFFLGGTLFDRVTPEMTIYKEEIFGPVLCIVRV 426 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAAN-DVIVHITLHSLPFGG 404 SLEEA+Q IN E +F+ + + + E G V N + V + HS FGG Sbjct: 427 NSLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEVGMVGVNVPLPVPVAYHS--FGG 484 Query: 405 VGNSGMGSYH--GKKSFETFSHRRSCLVR 431 S G H G ++ R++ R Sbjct: 485 WKRSLFGDLHAYGPDGVRFYTKRKAITQR 513 >2W8P-A nrPDB Length = 487 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 107/369 (28%), Positives = 173/369 (46%), Gaps = 35/369 (9%) Query: 80 EWAADEP------VEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGN 133 EW ++E + TP + L + +P+GV VI WN+P + + + A+AAG Sbjct: 117 EWFSEEARRVYGDIIHTPAKDRRALVLK-QPIGVAAVITPWNFPSAMITRKVGAALAAGC 175 Query: 134 SVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFDHIL------- 185 +VV+KP+E + A LA + Q + +Y VI P + + KE + I Sbjct: 176 TVVVKPAEDTPFSALALAELASQAGIPSGVYNVI----PCSRKNAKEVGEAICTDPLVSK 231 Query: 186 --YTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQT 243 +TGST GKI++ AA + V++ELGG +P V + ++D A KF N+GQT Sbjct: 232 ISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQT 291 Query: 244 CVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVM---- 295 V + L I + V E +KK+L+ G ++ G +I+ + ++V Sbjct: 292 AVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQGPLINEKAVEKVEKQVN 349 Query: 296 -GLIEGQKVAYGGT-GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQ 353 + +G V GG + PT+L +V EE FGP+ P++ + EEAI Sbjct: 350 DAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIA 409 Query: 354 FINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSY 413 N + LA Y +S + I ++ + G V N+ + I+ PFGGV SG+G Sbjct: 410 IANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGRE 467 Query: 414 HGKKSFETF 422 K + + Sbjct: 468 GSKYGIDEY 476 >3R64-A nrPDB Length = 508 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 96/337 (28%), Positives = 165/337 (48%), Gaps = 23/337 (6%) Query: 106 GVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPV 165 GVV VI WN+P NL+I+ + A+A GN+VV+KP+ + + +IP + ++ V Sbjct: 150 GVVGVISPWNFPLNLSIRSVAPALAVGNAVVIKPASDT----PVTGGVIPARIFEEAG-V 204 Query: 166 INGGVPETTELLKERFDH---------ILYTGSTGVGKIIMTAAAKH--LTPVTLELGGK 214 G + E DH I +TGST VG+ + A + V LELGG Sbjct: 205 PAGVISTVAGAGSEIGDHFVTHAVPKLISFTGSTPVGRRVGELAINGGPMKTVALELGGN 264 Query: 215 SPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YG 273 +P V + D+D A + A G F++ GQ C++ + ++ D ++ ++ +EK +++K G Sbjct: 265 APFVVLADADIDAAAQAAAVGAFLHQGQICMSINRVIVDAAVHDEFLEKFVEAVKNIPTG 324 Query: 274 EDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGT----GDAATRYIAPTILTDVDPQSP 329 + + + G +I+ + IE K G T G R + P + +DV Sbjct: 325 DPSAEGTLVGPVINDSQLSGLKEKIELAK-KEGATVQVEGPIEGRLVHPHVFSDVTSDME 383 Query: 330 VMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAAN 389 + +EEIFGP++ ++ A + N + L+ ++S + + + SG V N Sbjct: 384 IAREEIFGPLISVLKADDEAHAAELANASDFGLSAAVWSKDIDRAAQFALQIDSGMVHIN 443 Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRR 426 D+ V+ H + FGG NSG+G ++G + E F+ R Sbjct: 444 DLTVNDEPHVM-FGGSKNSGLGRFNGDWAIEEFTTDR 479 >1T90-A nrPDB Length = 486 Score = 112 bits (280), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 105/440 (23%), Positives = 197/440 (44%), Gaps = 17/440 (3%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 I A + A AF + + R + L Q+L+ + ++EL + + KN A E Sbjct: 45 IDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL-GE 103 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 V +E +E+ P + + + Y + P+GVV I +N+P + Sbjct: 104 VGRGIENVEFA-AGAPSLMMGDSLASIATDVEAANYRY--PIGVVGGIAPFNFPMMVPCW 160 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE-RF 181 AIA GN+ +LKPSE + + L + + L K ++ V+ G +L+ Sbjct: 161 MFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHPEI 220 Query: 182 DHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSG 241 I + GS VG+ + +++L V G K+ V + +L+ I F ++G Sbjct: 221 KAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAG 280 Query: 242 QTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVM----- 295 + C+A + + I ++ + KL++ + + G G +I + +R + Sbjct: 281 ERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEK 340 Query: 296 GLIEGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQ 353 GL EG ++ G + + ++ PTI +V + + ++EIF PVL ++ V++L+EAI+ Sbjct: 341 GLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIE 400 Query: 354 FINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSY 413 N+ E +F+SN I + E G+ ++ V + PF G +S G+ Sbjct: 401 IANKSEFANGACLFTSNSNAI-RYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTL 459 Query: 414 H--GKKSFETFSHRRSCLVR 431 H GK S + ++ ++ R Sbjct: 460 HANGKDSVDFYTRKKVVTAR 479 >4OGD-A nrPDB Length = 465 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 108/451 (23%), Positives = 195/451 (43%), Gaps = 23/451 (5%) Query: 4 ISEAVKRARAAFSSGRTRP-LQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 +++ ++RA + R L+ R QL + +++ + + D+ K + Sbjct: 25 LADVLERAHLLYKKWRKEDHLEERKAQLHQVANILRRDRDKYAEIMTKDMGK-LFTEAQG 83 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 EV + +Y K E+ P+E T + Y + GV+L + WN+P+ + Sbjct: 84 EVDLCADIADYYADKADEFLMSTPLE----TDSGQAYYLKQSTGVILAVEPWNFPYYQIM 139 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVP--ETTELLKE- 179 + GN +VLK + + A ++ + + + N + + ++++ + Sbjct: 140 RVFAPNFIVGNPMVLKHASICPRSAQSFEELVLE-AGAEAGSITNLFISYDQVSQVIADK 198 Query: 180 RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 R + TGS G I A K+L TLELGG + + D D + + + + N Sbjct: 199 RVVGVCLTGSERGGASIAEEAGKNLKKTTLELGGDDAFIILDDADWDQLEKVLYFSRLYN 258 Query: 240 SGQTCVAPD-YILCDPSIQ--NQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVM- 295 +GQ C + +I+ D +++ K+ K+ K +G+ + SA+ V+ Sbjct: 259 AGQVCTSSKRFIVLDKDYDRFKELLTKVFKTAK--WGDPMDPETTLAPLSSAQAKADVLD 316 Query: 296 ----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350 L G ++ YGG D ++ PTI+ + +P+ +EIFGPV I V S EE Sbjct: 317 QIKLALDHGAELVYGGEAIDHPGHFVMPTIIAGLTKDNPIYYQEIFGPVGEIYKVSSEEE 376 Query: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410 AI+ N L +FSSN + K + A+ +G N +L LPFGG+ +SG Sbjct: 377 AIEVANDSNYGLGGTIFSSNQEHAKAVAAKIETGMSFINSGWT--SLPELPFGGIKHSGY 434 Query: 411 GSYHGKKSFETFSHRRSCLVRPLMNDEGLKV 441 G + F +F + + N+ KV Sbjct: 435 GRELSELGFTSFVNEHLIYIPNKTNNSNTKV 465 >3ROS-A nrPDB Length = 484 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 105/425 (24%), Positives = 174/425 (40%), Gaps = 30/425 (7%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 +I EA+ A A + R R + L + ++E E EL + ++ K Sbjct: 27 QIDEAINLAHALYKKWRHEEPASRAEILHDIANALKEHEDELAKMMTLEMGK-------- 78 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL---YIHSEPLGVVLVIGTWNYPFN 119 + EE+E + +A P P +L Y + GV++ WN+P Sbjct: 79 LLSESKEEVELCVSICNYYADHGPEMLKPTKLNSDLGNAYYLKQSTGVIMACEPWNFPLY 138 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATII-----PQYLDKDLYPVINGGVPETT 174 I+ GN ++LK + A+L A II P+ +LYP + + Sbjct: 139 QVIRVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPEGSLINLYPSYD----QLA 194 Query: 175 ELLKE-RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 +++ + R + TGS G + AA K+L T+ELGG V + D V + Sbjct: 195 DIIADPRIQGVALTGSERGGSAVAEAAGKNLKKSTMELGGNDAFIVLDDADPQVLRNVLN 254 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQR 293 + N GQ C + I+ + S ++++ +LK D ++ +++ + Sbjct: 255 DARTYNDGQVCTSSKRIIVEKSRYDEVLHELKNVFSNLKAGDPLEADTTLPPMNSEKAKE 314 Query: 294 VM------GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346 + + G KV Y D+ + PTILTD+ +PV +E+FGP+ + V Sbjct: 315 KLEAQVKEAIDAGAKVFYQYPEIDSKGAFFRPTILTDIAKDNPVFDKEVFGPIAEVFVVE 374 Query: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406 AIQ N L + S+ KK+ A+ +G N IT LPFGG+ Sbjct: 375 DDNAAIQLANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVING--RWITSGELPFGGIK 432 Query: 407 NSGMG 411 SG G Sbjct: 433 KSGYG 437 >5N5S-A nrPDB Length = 515 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 89/318 (27%), Positives = 148/318 (46%), Gaps = 17/318 (5%) Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDL- 162 P+G V ++ WN+P NL + AIA G VLKP+ + A +L I+ + + L Sbjct: 178 PIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASRTPLSALILGEILHKIEELPLG 237 Query: 163 ----YPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCY 218 PV T + ERF + +TGS +G + A K V +ELGG +PC Sbjct: 238 AFSILPVSREDADMFT--VDERFKLLTFTGSGPIGWDMKARAGKK--KVVMELGGNAPCI 293 Query: 219 VDKNC-DLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDA 276 VD DLD +R+ G F GQ+C+ + + +++ E ++K+ G Sbjct: 294 VDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDEVKEGFVAAVKKLKMGNPF 353 Query: 277 KKSRDYGRIISARHFQRVMGLIEGQKVAYGGT----GDAATRYIAPTILTDVDPQSPVMQ 332 ++ G +IS + + ++ + VA GG G+ +I PT++ DV ++ + Sbjct: 354 EEDTYLGPMISESAAKGIEDWVK-EAVAKGGKLLTGGNRKGAFIEPTVIEDVPIEANARK 412 Query: 333 EEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVI 392 EEIFGPV+ + +EA++ N L +F+ + GGV ND Sbjct: 413 EEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGIFTKDLNKAFYAFEHMEVGGVILNDSP 472 Query: 393 VHITLHSLPFGGVGNSGM 410 + + S P+GG+ +SG+ Sbjct: 473 A-LRVDSQPYGGLKDSGI 489 >2JG7-A nrPDB Length = 510 Score = 108 bits (270), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 81/342 (23%), Positives = 160/342 (46%), Gaps = 14/342 (4%) Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLY 163 P+G+V +I +N+P + A+ GN + K + + + + I+ + L+++ Sbjct: 155 PVGLVGIITAFNFPVAVYGWNNAIALTCGNVCLWKGAPTTPLTSVAVTKIVAEVLEQNNL 214 Query: 164 P-----VINGGVPETTELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPC 217 P + GG T + K ER D + +TGST VGK++ + LELGG + Sbjct: 215 PGAICSMTCGGADIGTAMAKDERVDLLSFTGSTHVGKMVAMMVQERFGRKLLELGGNNAI 274 Query: 218 YVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDA 276 V ++ DL++ + +GQ C ++ S+ + +VE++ K+ K+ G+ Sbjct: 275 IVFEDADLNLVVPSAVFASVGTAGQRCTTTRRLMLHESVHDAVVERIAKAYKQVRIGDPW 334 Query: 277 KKSRDYGRIISARHFQRVMGLIE------GQKVAYGGTGDAATRYIAPTILTDVDPQSPV 330 S YG + + + + + IE G V G D Y+ PTI+T + +P+ Sbjct: 335 DPSTLYGPLHTKQAVDQYLAAIEQAKQQGGTLVCGGKVMDRPGNYVEPTIITGLAHDAPI 394 Query: 331 MQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAAN 389 + E F P+L ++ ++ EEA + N+ ++ L+ +F+ + +V + + + S G+ Sbjct: 395 VHTETFVPILYVLKFKTEEEAFAWNNEVQQGLSSSIFTKDLGRVFRWLGPKGSDCGIVNV 454 Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 ++ FGG ++G G G S++ + R +C + Sbjct: 455 NIPTSGAEIGGAFGGEKHTGGGRESGSDSWKQYMRRSTCTIN 496 >4ZZ7-A nrPDB Length = 501 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 102/445 (22%), Positives = 193/445 (43%), Gaps = 23/445 (5%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 + +A+ A+ AF + R P R + + + L+++ E+ L + H + E Sbjct: 45 VEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEIC-RLIGEEHGKIAHDAMGE 103 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 + +E +EY + P + + +P+GVV I +N+P + + Sbjct: 104 LQRGIENVEYACGAPELLKGEHSRNVGPGI---DSWSEFQPMGVVAGITPFNFPVMVPLW 160 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL-KERF 181 AI GN VLKPSE + +A ++ + L + V+NG LL +R Sbjct: 161 MFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDRV 220 Query: 182 DHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSG 241 + + GST + + I A+ + G K+ V + D+D A ++ F +SG Sbjct: 221 KAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSG 280 Query: 242 QTCVAPDY-ILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI- 298 + C+A + + + +V K+ +++++ G D+G +I+ +H ++V+G I Sbjct: 281 ERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYIN 340 Query: 299 ----EGQKVAYGGTGDAATR-----YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 +G + G ++ T++ V P+ QEEIFGPVL +V V +++ Sbjct: 341 SAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQ 400 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAAN-DVIVHITLHSLPFGGVGNS 408 +A+ I+ E +F+ + + + G V N + V + HS FGG S Sbjct: 401 DAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGINIPLPVPVAYHS--FGGWKRS 458 Query: 409 GMGSYH--GKKSFETFSHRRSCLVR 431 G H G + ++ R++ R Sbjct: 459 LFGDLHAYGPDAVRFYTKRKTVTQR 483 >4PXN-A nrPDB Length = 525 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 86/343 (25%), Positives = 161/343 (46%), Gaps = 15/343 (4%) Query: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDL 162 PLGVV VI +N+P + A+ GN VV K + + + + I+ L+K+ Sbjct: 170 NPLGVVGVITAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMTKIVASVLEKNN 229 Query: 163 YP-VINGGVPETTEL-----LKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSP 216 P I TE+ L R + +TGST G ++ + LEL G + Sbjct: 230 LPGAIFTSFCGGTEIGQAIALDIRIPLVSFTGSTRAGLMVQQQVSARFGKCLLELSGNNA 289 Query: 217 CYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGED 275 V + D+ +A R + + +GQ C ++ +I +++L + K+ G+ Sbjct: 290 IIVMDDADIQLAVRSVLFAAVGTAGQRCTTCRRLILHENIYQTFLDQLVEVYKQVRIGDP 349 Query: 276 AKKSRDYGRI---ISARHFQRVMGLI--EGQKVAYGGTG-DAATRYIAPTILTDVDPQSP 329 +K G + S +F + + I +G K+ +GG+ ++ ++ PTI+ ++ P +P Sbjct: 350 LEKGTLLGPLHTPASKENFLKGIQTIKSQGGKILFGGSAIESEGNFVQPTIV-EITPSAP 408 Query: 330 VMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIA-ETSSGGVAA 388 V++EE+FGPVL ++ ++L+EAI+ N + L+ +F+ +I K + S G+ Sbjct: 409 VVKEELFGPVLYVMKFQTLKEAIEINNSVPQGLSSSIFTKRPDIIFKWLGPHGSDCGIVN 468 Query: 389 NDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 ++ + FGG +G G G S++ + R +C + Sbjct: 469 VNIPTNGAEIGGAFGGEKATGGGREAGSDSWKQYMRRATCTIN 511 >4KNA-A nrPDB Length = 495 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 107/419 (25%), Positives = 177/419 (42%), Gaps = 21/419 (5%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 + AV AR AF++ L R ++ L+ E+++ L + + K W A E Sbjct: 48 VERAVASARRAFAAWSALDLDARCTIVKRFAALLVERKEALATMIGRETGKPLWEAR-TE 106 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 V + +++ I E ++ + P + H P GVV V G +N+P +L Sbjct: 107 VASMAAKVDISITAYHERTGEK---RAPMADGVAVLRH-RPHGVVAVFGPYNFPGHLPNG 162 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER-F 181 +V A+ AGN+VV KPSEL+ +A I L + ++ G L R Sbjct: 163 HIVPALIAGNTVVFKPSELAPGVARATVEIWRDAGLPAGVLNLVQGEKDTGVALANHRQI 222 Query: 182 DHILYTGSTGVGKIIMTA-AAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240 D + +TGS+ G ++ + + LE+GG +P V + D+D A F+++ Sbjct: 223 DGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVVAEVEDIDAAVHHAIQSAFLSA 282 Query: 241 GQTCVAPDYILC-DPSIQNQIVEKLKKSLKEFYGE--DAKKSRDYGRIISARHFQRVMGL 297 GQ C IL + ++ V +L + DA G +ISAR R++ Sbjct: 283 GQRCTCARRILVPRGAFGDRFVARLADVASKITASVFDADPQPFMGAVISARAASRLVA- 341 Query: 298 IEGQKVAYGGT-------GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350 + + V G + D A ++ IL DV + EE FGP+ IV L++ Sbjct: 342 AQARLVGLGASPIIEMKQRDPALGFVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTDLDD 400 Query: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 AI N L+ + + +++ +G V N + + PFGG G SG Sbjct: 401 AIARANDTAFGLSAGLLADDEQAWHTFRRAIRAGIVNWNRPTNGAS-SAAPFGGAGRSG 458 >4X0T-A nrPDB Length = 513 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 78/341 (22%), Positives = 153/341 (44%), Gaps = 14/341 (4%) Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLY 163 P+G+V +I +N+P + A+ GN + K + + ++ + II + L+ + Sbjct: 158 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 217 Query: 164 P-----VINGGVPETTELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPC 217 P + GG T + K ER + + +TGST VGK + + LELGG + Sbjct: 218 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAI 277 Query: 218 YVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDA 276 ++ DL + + +GQ C + SI +++V +LKK+ + G Sbjct: 278 IAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPW 337 Query: 277 KKSRDYGRIISARHFQRVMGLI-----EGQKVAYGG-TGDAATRYIAPTILTDVDPQSPV 330 + YG + + + +G + EG V YGG D Y+ PTI+T + + + Sbjct: 338 DPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASI 397 Query: 331 MQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAAN 389 E F P+L + ++ EE + N+ ++ L+ +F+ + ++ + + + S G+ Sbjct: 398 AHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNV 457 Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430 ++ FGG ++G G G +++ + R +C + Sbjct: 458 NIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 498 >4E4G-A nrPDB Length = 521 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 100/425 (23%), Positives = 182/425 (42%), Gaps = 23/425 (5%) Query: 24 QFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAA 83 Q R + +L+ + EL L+ + H + ++V LE E++I +P Sbjct: 86 QRRARVFMKFVQLLNDNMNELAEMLSRE-HGKTIDDAKGDIVRGLEVCEFVI-GIPHLQK 143 Query: 84 DEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELS 143 E E ++Y +P+G+ I +N+P + + AIA GN+ +LKPSE Sbjct: 144 SEFTEGA--GPGIDMYSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNAFILKPSERD 201 Query: 144 ENMASLLATI-IPQYLDKDLYPVINGGVPETTELLKE-RFDHILYTGSTGVGKIIMTAAA 201 ++ LA + I L + V+NG +L + + GST + + + AA Sbjct: 202 PSVPIRLAELMIEAGLPAGILNVVNGDKGAVDAILTHPDIAAVSFVGSTPIARYVYGTAA 261 Query: 202 KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYIL-CDPSIQNQI 260 + G K+ + + DLD A + + ++G+ C+A + N++ Sbjct: 262 MNGKRAQCFGGAKNHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVPVGEETANRL 321 Query: 261 VEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE-----GQKVAYGG-----TG 309 ++KL ++ G + D G +++ QR+ LI+ G K+ G G Sbjct: 322 IDKLVPMVESLRIGPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVVDGRDFKLQG 381 Query: 310 DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSS 369 +I + DV P + + EIFGPVL +V R+ EEA+ + E + +++ Sbjct: 382 YENGHFIGGCLFDDVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEYGNGVAIYTR 441 Query: 370 NDKVIKKMIAETSSGGVAANDVI-VHITLHSLPFGGVGNSGMG--SYHGKKSFETFSHRR 426 + + + + G V N I V + HS FGG +S G + HG S + ++ + Sbjct: 442 DGDAARDFASRINIGMVGVNVPIPVPLAYHS--FGGWKSSSFGDLNQHGTDSIKFWTRTK 499 Query: 427 SCLVR 431 + R Sbjct: 500 TITSR 504 >3V9H-A nrPDB Length = 566 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 105/440 (23%), Positives = 177/440 (40%), Gaps = 44/440 (10%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQ-QLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 S +++A++ A AA +P+ R Q L+A L + E++ K A Sbjct: 103 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 162 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 + +++ + + E +P+ P T ++ G V I PFN Sbjct: 163 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 215 Query: 121 TI--QPMVGAIA-AGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177 T + GA A GN V+ KPS+ + + + I+ + L P I VP L Sbjct: 216 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRIL---REAGLPPNIIQFVPADGPLF 272 Query: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225 E I +TGS K + A++L + E GGK+ +V ++ D+ Sbjct: 273 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 332 Query: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284 + F GQ C A + S+ QI +L + D + D+G Sbjct: 333 ESVVSGTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSRIKVGD--PAEDFGTF 390 Query: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334 +I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE Sbjct: 391 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 450 Query: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKKM--IAETSSGGVAAN 389 IFGPVL + +E +Q ++ L +FS + V+++ + ++G N Sbjct: 451 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 510 Query: 390 DVIVHITLHSLPFGGVGNSG 409 D + PFGG SG Sbjct: 511 DKSTGSIVGQQPFGGARASG 530 >6DBB-A nrPDB Length = 511 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 96/444 (21%), Positives = 190/444 (42%), Gaps = 35/444 (7%) Query: 8 VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQEL--VGALAADLHKNEWNAYYEEVV 65 + A AF RT P R + + +++E + EL + L A +E +E++ Sbjct: 56 IDAAHDAFLKWRTVPAPVRGELVRVFGNVLREHKAELGRLVTLEAGKITSEGLGEVQEMI 115 Query: 66 YVLEEIEYMIQKL--PEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 + + + ++L A++ P + +T P+GV VI +N+P + Sbjct: 116 DICDFAVGLSRQLYGLTIASERPGHRMMETWH--------PIGVCGVISAFNFPVAVWAW 167 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDK------DLYPVING----GVPET 173 A G+SVV KPSE + A ++ + L + + P G G+ + Sbjct: 168 NAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKALREFEKTHPGVAPAELGQLVLGMRDV 227 Query: 174 TELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231 E+L ++ + TGS +G+ + ++ L LELGG + V + DLD+ R Sbjct: 228 GEVLTASKKVPVVSATGSVRMGQEVAKVLSQRLARGILELGGNNGMIVAPSADLDLVVRA 287 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARH 290 + + +GQ C ++ S+ Q++ +++K+ G ++ G ++ Sbjct: 288 VTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIEKAYASVKVGNPLEEGTLVGPLVDRAS 347 Query: 291 FQRVMGLI-----EGQKVAYG---GTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI 342 F + + +G +V G G A Y+ P I+ + QS V++ E F P+L + Sbjct: 348 FDAMQKALADAREQGGEVKGGERVDVGHADAYYVRPAIVR-MPKQSAVVERETFAPILYV 406 Query: 343 VCVRSLEEAIQFINQREKPLALYMFSSNDKVIKK-MIAETSSGGVAANDVIVHITLHSLP 401 + + ++AI N + L+ +F+++ + ++ M A S G+ ++ Sbjct: 407 MVYDNFDDAIDVHNAVPQGLSSAIFTNDMREAEQFMSAAGSDCGIVNVNIGTSGAEIGGA 466 Query: 402 FGGVGNSGMGSYHGKKSFETFSHR 425 FGG +G G G +++ + R Sbjct: 467 FGGEKETGGGRESGSDAWKAYMRR 490 >4OE4-A nrPDB Length = 580 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 104/419 (24%), Positives = 170/419 (40%), Gaps = 48/419 (11%) Query: 30 LEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEK 89 L+A + + +++ A KN + A + + + + Y ++ + A +PVE Sbjct: 128 LKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVES 187 Query: 90 TPQTQQDELYIHSEPL-GVVLVIGTWNYPFNLTI--QPMVGAIA-AGNSVVLKPSELSEN 145 T Y PL G V + PFN T ++GA A GN+VV KPS+ + Sbjct: 188 ADGTWNKAEY---RPLEGFVYAVS----PFNFTAIAANLIGAPALMGNTVVWKPSQTAAL 240 Query: 146 MASLLATIIPQY-LDKDLYPVINGGVPETTE--LLKERFDHILYTGSTGV-----GKI-- 195 LL T++ + L K + I G + T+ L + F + +TGST V GKI Sbjct: 241 SNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQS 300 Query: 196 -IMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDP 254 ++ + + E GGK+ V + ++ A G F GQ C A + Sbjct: 301 GVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPE 360 Query: 255 S------------IQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQK 302 S +Q+Q V + S G + + G +I + F +++ +IE K Sbjct: 361 SKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFM--GPVIHEQSFDKLVKVIEDAK 418 Query: 303 ------VAYGGTGDAAT-RYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE--EAIQ 353 + YGG D + ++ PT++ P P M E FGP+L + E E Sbjct: 419 KDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEICD 478 Query: 354 FI-NQREKPLALYMFSSNDKVIKKMIAET--SSGGVAANDVIVHITLHSLPFGGVGNSG 409 I N + L +F+ + K I+ + S+G ND + FGG SG Sbjct: 479 IIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWFGGARMSG 537 >4LGZ-A nrPDB Length = 563 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 103/444 (23%), Positives = 174/444 (39%), Gaps = 44/444 (9%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 ++ A+ A AA +P+ R Q L+A L + E++ K A + Sbjct: 102 LNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEID 161 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 +++ + + E ++P+ P T ++ G V I PFN T Sbjct: 162 AAAELIDFFRFNAKFAVELEGEQPISVPPSTNHT---VYRGLEGFVAAIS----PFNFTA 214 Query: 123 --QPMVGAIA-AGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPET------ 173 + GA A GN V+ KPS+ + + + I+ + L P I VP Sbjct: 215 IGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRIL---REAGLPPNIIQFVPADGPTFGD 271 Query: 174 TELLKERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDLDV 227 T E I +TGS K + A++L + E GGK+ +V + D+D Sbjct: 272 TVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDS 331 Query: 228 ACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR--- 284 F GQ C A + S+ QI +L + D + D+G Sbjct: 332 VVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGD--PAEDFGTFFS 389 Query: 285 -IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIF 336 +I A+ F R+ +E + +A G ++ Y+ P I+ DPQ P+M+EEIF Sbjct: 390 AVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIF 449 Query: 337 GPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKKM--IAETSSGGVAANDV 391 GPVL + E ++ ++ L +F+ + ++++ + ++G ND Sbjct: 450 GPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDK 509 Query: 392 IVHITLHSLPFGGVGNSGMGSYHG 415 + PFGG SG G Sbjct: 510 STGSVVGQQPFGGARASGTNDKPG 533 >5UJU-A nrPDB Length = 576 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 89/361 (24%), Positives = 143/361 (39%), Gaps = 53/361 (14%) Query: 67 VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSE----PLGVVLVIGTWNYPFNLTI 122 LE + Y +L AD EK PQ + L + P G LV+G +P Sbjct: 164 ALEAVAYAWDQLRRIPADAHWEK-PQGKNPPLAMQKRYTIVPRGTGLVLGCCTFPTWNGY 222 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLY------PVI--------NG 168 + +A GN+V++KP + ++L I + +D+ P + N Sbjct: 223 PGLFADLATGNTVIVKP-----HPGAILPLAITVRIARDVLREAGFDPNVVTLLATEPND 277 Query: 169 GVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVA 228 G L+ I +TGST G + A H V E G + +D DL A Sbjct: 278 GALVQDLALRPEIKLIDFTGSTQNGTWLERHA--HQAQVYTEKAGVNQIVIDSTDDLKAA 335 Query: 229 CRRIAWGKFMNSGQTCVAPDYILC---------DPSIQNQIVEKLKKSLKEFYGEDAKKS 279 + IA+ + SGQ C AP I + +++ + + ++++ G+ A+ Sbjct: 336 AKNIAFSLALYSGQMCTAPQNIYVPRDGIRTADGHASFDEVAQAIAGAVQKLTGDPARSV 395 Query: 280 RDYG---------RIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILT-DVDPQSP 329 G RI +AR RV L++ Q + + DA R P +L DV + Sbjct: 396 ELIGAIQNDGVTARIDAARAVGRV--LLDSQTLQHPAFPDARVR--TPLVLQLDVADREK 451 Query: 330 VMQEEIFGPVLPIVCVRSLEEAIQF---INQREKPLALYMFSSNDKVIKKMIAETSSGGV 386 Q E FGP+ ++ S +++ I L L ++S+ D VI GGV Sbjct: 452 FTQ-EWFGPISFVIATDSTAQSLDLAGEIAAEHGALTLSVYSTADDVIDAAHEAAVRGGV 510 Query: 387 A 387 A Sbjct: 511 A 511 >5JFN-A nrPDB Length = 524 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 79/357 (22%), Positives = 152/357 (42%), Gaps = 46/357 (12%) Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLD---- 159 P GV+ I P + +G +AAGNSVV P + ++ LL +I Q L Sbjct: 187 PFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVFSPHPRARQVSLLLVRLINQKLAALGA 246 Query: 160 -KDLYPVINGGVPETTELLKE--RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSP 216 ++L + E T + + ++ TG + K +++ K + G P Sbjct: 247 PENLVVTVEKPSIENTNAMMAHPKVRMLVATGGPAIVKAVLSTGKKAIG----AGAGNPP 302 Query: 217 CYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDA 276 VD+ +++ A I G ++ VA I+ I + ++ LKK+ + A Sbjct: 303 VVVDETANIEKAACDIVNGCSFDNNLPXVAEKEIIAVAQIADYLIFNLKKNGAYEIKDPA 362 Query: 277 KKSRDYGRIISARHFQRVMGLIEGQKVAY-----GGTGDAATRYIAPTILTDVDPQSPVM 331 + +++A+ + + G+ + G + DA+ + IL +V + P + Sbjct: 363 VLQQLQDLVLTAKGGPQTKCV--GKSAVWLLSQIGISVDASIKI----ILMEVPREHPFV 416 Query: 332 QEEIFGPVLPIVCVRSLEEAIQF---INQREKPLALYMFSSNDKVIKKMIAETSSGGVAA 388 QEE+ P+LP+V V ++++AI + + A+ M S++ + + KM A Sbjct: 417 QEELMMPILPLVRVETVDDAIDLAIEVEHDNRHTAI-MHSTDVRKLTKM----------A 465 Query: 389 NDVIVHITLHSLP-FGGVGNSGMG---------SYHGKKSFETFSHRRSCLVRPLMN 435 + I + + P + G+G G G + G S ++F+ RR C++ +N Sbjct: 466 KLIQTTIFVKNGPSYAGLGAGGEGYSTFTIAGPTGEGLTSAKSFARRRKCVMVEALN 522 >4IDS-A nrPDB Length = 563 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 92/343 (26%), Positives = 132/343 (38%), Gaps = 50/343 (14%) Query: 40 QEQELVGALAADLHKNEW--------------NAYYEEVVYVLEEIEYMIQKLPEWAADE 85 E+ V AADL W + Y E+ V E I++ + A + Sbjct: 121 DERAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFW--RFNVAFARQ 178 Query: 86 PVEKTPQTQQDEL-YIHSEPL-GVVLVIGTWNYPF---NLTIQPMVGAIAAGNSVVLKPS 140 +E+ P + E I PL G V I +N+ NL P + GN+V+ KPS Sbjct: 179 ILEQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPAL----MGNTVIWKPS 234 Query: 141 ELSENMASLLATIIPQYLDKDLYP--VIN-----GGVPETTELLKERFDHILYTGSTGV- 192 +++ +A+ L Q L+ P VIN G L R I +TGST Sbjct: 235 -ITQTLAAYLTM---QLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATF 290 Query: 193 GKIIMTAAAK----HLTP-VTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247 G + H P + E GGK + DV + G F GQ C A Sbjct: 291 GHLWQWVGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSAV 350 Query: 248 DYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIEGQK---- 302 S+ ++ ++L E YG+ S G +I R F + + IE K Sbjct: 351 SRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAA 410 Query: 303 --VAYGGTGDAATRY-IAPTILTDVDPQSPVMQEEIFGPVLPI 342 VA GG D + Y + PT+L DP E FGP+L + Sbjct: 411 VTVAVGGEYDDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSV 453 >1O20-A nrPDB Length = 427 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 93/437 (21%), Positives = 170/437 (38%), Gaps = 76/437 (17%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 M ++ E K+ R A+ R + + + ++ + + E+ +E++ A D+ K Sbjct: 13 MDELLEKAKKVREAWDVLRNATTREKNKAIKKIAEKLDERRKEILEANRIDVEKARERGV 72 Query: 61 YEEVVYVL----EEIEYMIQKLPE-WAADEPVEKTPQT--QQDELYIHSE--PLGVVLVI 111 E +V L + I+ MI+ +PV + + ++D L I P+G + +I Sbjct: 73 KESLVDRLALNDKRIDEMIKACETVIGLKDPVGEVIDSWVREDGLRIARVRVPIGPIGII 132 Query: 112 GTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVP 171 + N+T++ + A+ +GN+++L+ + N + + I + L + P + Sbjct: 133 --YESRPNVTVETTILALKSGNTILLRGGSDALNSNKAIVSAIREALKETEIPESSVEFI 190 Query: 172 ETTE--------LLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELG-GKSPCYVDKN 222 E T+ L+E ++ G G+ + A PV LE G G +VD++ Sbjct: 191 ENTDRSLVLEMIRLREYLSLVIPRGGYGLISFVRDNAT---VPV-LETGVGNCHIFVDES 246 Query: 223 CDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ----IVEKLKKSLKEFYGEDAKK 278 DL A I K G TC A + +L I + IVE+L+K Sbjct: 247 ADLKKAVPVIINAKTQRPG-TCNAAEKLLVHEKIAKEFLPVIVEELRK------------ 293 Query: 279 SRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGP 338 H V G TR I P ++ + P E Sbjct: 294 -----------HGVEVRGC-------------EKTREIVPDVVPATEDDWPT---EYLDL 326 Query: 339 VLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH 398 ++ I V++++EAI+ I + + + + N KK ++E + V N Sbjct: 327 IIAIKVVKNVDEAIEHIKKYSTGHSESILTENYSNAKKFVSEIDAAAVYVN--------A 378 Query: 399 SLPFGGVGNSGMGSYHG 415 S F G G G+ G Sbjct: 379 STRFTDGGQFGFGAEIG 395 >3V4C-A nrPDB Length = 528 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 82/379 (21%), Positives = 142/379 (37%), Gaps = 53/379 (13%) Query: 88 EKTPQTQQDELYIHSEPLGVVLVIGTWNYP--FNLTIQPMVGAIAAGNSVVLKPSELSEN 145 E+ P +Q E+ + P+G V V G N+P F+ A+AAG VV+K Sbjct: 154 ERQPAPRQ-EIRLVQRPVGPVAVFGASNFPLAFSTAGGDTAAALAAGCPVVVKGHSAHPG 212 Query: 146 MASLLATIIPQYLDK-----DLYPVINGGVPETTELLKE--RFDHILYTGSTGVGKIIMT 198 ++A + + K ++ +I GG + L + + +TGS G+ + Sbjct: 213 TGEIVAEAVDAAIRKTGVHPGVFSLIQGGSRDVGHALVQHPHIKAVGFTGSLAGGRALFD 272 Query: 199 AAAKHLTPVTL--ELGGKSPCYV---DKNCDLDVACRRIAWGKFMNSGQTCVAPDYILC- 252 A P+ ELG +P ++ + + A M +GQ C P + Sbjct: 273 LCAARPEPIPFFGELGSVNPMFLLPEALKARAETLGQGWAGSLTMGAGQFCTNPGIAVVI 332 Query: 253 ----DPSIQNQIVEKLKKSLKEFYGED--AKKSRDYGRIISARHFQRVMGLIEGQKVAYG 306 VE L K + D AK RD + R+ + + E Sbjct: 333 EGADADRFTTAAVEALAKVAPQTMLTDGIAKAYRDGQARFATRNAVKPLLATE------- 385 Query: 307 GTGDAATRYIAPTILTDVDPQ---SPVMQEEIFGPVLPIVCVRSLEEAIQFIN--QREKP 361 ++ R +P + Q + EE+FGP+ +V V S E + Q + Sbjct: 386 ----SSGRDASPNLFETTGAQFLADHALGEEVFGPLGLVVRVGSPAEMEELARGFQGQLT 441 Query: 362 LALYMFSSNDKVIKKM--IAETSSGGVAANDV-----IVHITLHSLPFGGVGNSGMGSYH 414 ++M + + + +++ + E +G V N +V +H P+ N Sbjct: 442 ATIHMDAGDLETARRLRPVLERKAGRVLVNGFPTGVEVVDSMVHGGPYPASTN------F 495 Query: 415 GKKSFETFSHRRSCLVRPL 433 G S T S RR +RP+ Sbjct: 496 GATSVGTMSIRR--FLRPV 512 >5DBV-A nrPDB Length = 445 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 72/368 (19%), Positives = 143/368 (38%), Gaps = 37/368 (10%) Query: 88 EKTPQTQ----------QDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVL 137 EKTP T+ + + P GV+ I P I +G +A GN+VV Sbjct: 83 EKTPGTEDITTTAWSGDRGLTLVEMGPFGVIGAITPCTNPSETIICNTIGMLAGGNTVVF 142 Query: 138 KPSELSENMASLLATIIPQYLDKDLYPV-----INGGVPETTELLKERFD--HILYTGST 190 P + ++ +I + PV + ++++++ D I TG Sbjct: 143 NPHPAAIKTSNFAVQLINEASLSAGGPVNIACSVRKPTLDSSKIMMSHQDIPLIAATGGP 202 Query: 191 GVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYI 250 GV ++ + + + G P VD+ D+ A I G ++ +A + Sbjct: 203 GVVTAVLQSGKRGIGAG----AGNPPVLVDETADIRKAAEDIINGCTFDNNLPAIAEKEV 258 Query: 251 LCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGD 310 + +I N+++ + K + ++ + +I+ + R + + + G G Sbjct: 259 VAIDAIANELMNYMVKEQGCYAITKEQQEKLTNLVITPKGLNRNC-VGKDARTLLGMIGI 317 Query: 311 AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSN 370 I I+ + + + P++ EE+ P+L IV +S ++A+ EK + L + + Sbjct: 318 DVPSNIR-CIIFEGEKEHPLISEELMMPILGIVRAKSFDDAV------EKAVWLEHGNRH 370 Query: 371 DKVI-KKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSY-------HGKKSFETF 422 I K + ++ A + I+ S G G G ++ G S TF Sbjct: 371 SAHIHSKNVDRITTYAKAIDTAILVKNAPSYAAIGFGGEGFCTFTIASRTGEGLTSASTF 430 Query: 423 SHRRSCLV 430 + RR C++ Sbjct: 431 TKRRRCVM 438 >3K9D-A nrPDB Length = 464 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/184 (23%), Positives = 78/184 (42%), Gaps = 23/184 (12%) Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLAT--IIPQYLDKD 161 PLGVV + P + I + +I AGNS+V P + ++L T II + +K Sbjct: 108 PLGVVAGLIPSTNPTSTVIYKTLISIKAGNSIVFSPH--PNALKAILETVRIISEAAEKA 165 Query: 162 ----------LYPVINGGVPETTELLKERFDH-ILYTGSTGVGKIIMTAAAKHLTPVTLE 210 P I G T +L+K + IL TG G ++ AA TP Sbjct: 166 GCPKGAISCMTVPTIQG----TDQLMKHKDTAVILATG----GSAMVKAAYSSGTPAIGV 217 Query: 211 LGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKE 270 G P +++++ ++ A + I K ++G C + ++ + + ++ + +K Sbjct: 218 GPGNGPAFIERSANIPRAVKHILDSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQGAH 277 Query: 271 FYGE 274 F + Sbjct: 278 FLSD 281 >2Y53-A nrPDB Length = 534 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 63/322 (19%), Positives = 121/322 (37%), Gaps = 50/322 (15%) Query: 99 YIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYL 158 ++ S GV L I +N+P + A+ +G V++KP+ + A L ++ + Sbjct: 146 HVLSPTRGVALFINAFNFPSWGLWEKAAPALLSGVPVIVKPATAT---AWLTQRMVADVV 202 Query: 159 DKDLYP-----VINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGG 213 D + P +I G + ++ FD + +TGS TAA P ++ G Sbjct: 203 DAGILPPGALSIICGSSAGLLDQIRS-FDVVSFTGSAD------TAATLRAHPAFVQRGA 255 Query: 214 KSPCYVDK-------------NCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQI 260 + D D+ + + + SGQ C A + + Sbjct: 256 RLNVQADSLNSAILCADATPDTPAFDLFIKEVVREMTVKSGQKCTAIRRAFVPEAALEPV 315 Query: 261 VEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIEGQK----VAYGGTG----DA 311 +E LK L + G + G ++S ++ V+ I + +AY + DA Sbjct: 316 LEALKAKLAKITVGNPRNDAVRMGSLVSREQYENVLAGIAALREEAVLAYDSSAVPLIDA 375 Query: 312 ATRY---IAPTILTDVDPQSPVMQE--EIFGPVLPIVCVRSLEE--------AIQFINQR 358 +AP + DP + + E+FGPV + R + A+ + Sbjct: 376 DANIAACVAPHLFVVNDPDNATLLHDVEVFGPVASVAPYRVTTDTNALPEAHAVALARRG 435 Query: 359 EKPLALYMFSSNDKVIKKMIAE 380 + L ++S++D + ++ E Sbjct: 436 QGSLVASIYSNDDAHLGRLALE 457 >6D97-A nrPDB Length = 547 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 67/271 (24%), Positives = 108/271 (39%), Gaps = 58/271 (21%) Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLK-PSELSENMASLLATIIPQYLDKDL 162 P G V +I +N+P + + ++GA+ GN VLK S++S M ++ + L + Sbjct: 188 PYGPVAIITPFNFPLEIPLLQLMGALYMGNKPVLKVDSKVSIVMEQMIRLLHDCGLPAED 247 Query: 163 YPVING-GVPETTELLKERFDHILYTGSTGV---------GKIIMTAAA---KHLTPVTL 209 IN G LL+ L+TGS+ V G++ + A K L P Sbjct: 248 MDFINSDGAVMNKLLLEANPKMTLFTGSSRVAEKLAADLKGRVKLEDAGFDWKILGPDVQ 307 Query: 210 ELGGKSPCYVDKNCDLDV-ACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ-IVEKLKKS 267 E+ YV CD D AC SGQ C A + + + ++EK+KK Sbjct: 308 EVD-----YVAWVCDQDAYAC----------SGQKCSAQSVLFMHKNWSSSGLLEKMKKL 352 Query: 268 LKEFYGEDAKKSRDYGRIISA------RHFQRVMGLIEGQKVAYGGTGDAATRYIAPTIL 321 + ED G +++ H ++ I G KV +G G+ + P I Sbjct: 353 SERRKLEDLT----IGPVLTVTTEAMIEHMNNLLK-IRGSKVLFG--GEPLANHSIPKIY 405 Query: 322 TDVDPQS--------------PVMQEEIFGP 338 + P + ++ +EIFGP Sbjct: 406 GAMKPTAVFVPLEEILKSGNFELVTKEIFGP 436 >3EDP-A nrPDB Length = 236 Score = 33.1 bits (74), Expect = 0.29, Method: Compositional matrix adjust. Identities = 43/150 (28%), Positives = 61/150 (40%), Gaps = 23/150 (15%) Query: 256 IQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRY 315 ++N E LKK +K+FY A K Y I + + V + QK +G T D R Sbjct: 89 MKNDTNENLKKDIKDFYIRKAGKF--YAEIFGMKENELVYSIKFVQKSEHGATLD---RL 143 Query: 316 IAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS-------LEEAIQFINQREKPLALYMFS 368 I P L P +Q + F + I V S LE+ +Q I + + + Sbjct: 144 ILPLGLY------PDLQAKDFQIINIIELVNSGKYKLFELEQELQLILAGNEQIKNMHLN 197 Query: 369 SNDKVIKKMIAETSSGGVAANDVIVHITLH 398 ND V K SS A ND+ + I H Sbjct: 198 ENDPVFK-----LSSVFYAENDMPIAIQYH 222 >6GB2-BC nrPDB Length = 657 Score = 33.1 bits (74), Expect = 0.29, Method: Compositional matrix adjust. Identities = 28/119 (23%), Positives = 46/119 (38%), Gaps = 33/119 (27%) Query: 137 LKPSELSENMASLLATIIPQYLDKDLYPVIN--------------------GGVPETTEL 176 LKP E E +++L+ II +D + ++N G V Sbjct: 433 LKPKEKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDASHECELELVHFGVGDVSANDVN 492 Query: 177 LKERFDHILYTGSTGVGKIIMTAAAKHLTPVTL-------------ELGGKSPCYVDKN 222 L E FD ++Y + G +I +AAK + L EL + PC V+++ Sbjct: 493 LAETFDGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIYRLVEDLQEELSSRLPCAVEEH 551 >3MY7-A nrPDB Length = 452 Score = 32.0 bits (71), Expect = 0.53, Method: Compositional matrix adjust. Identities = 31/168 (18%), Positives = 67/168 (39%), Gaps = 7/168 (4%) Query: 102 SEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMAS-----LLATIIPQ 156 +EP+G++ I P + I + ++ N ++ P ++N + +L + Sbjct: 101 AEPVGIICGIVPTTNPTSTAIFKSLISLKTRNGIIFSPHPRAKNSTNDAAKLVLDAAVAA 160 Query: 157 YLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSP 216 KD+ I+ E + L + D L + G G ++ AA P G P Sbjct: 161 GAPKDIIGWIDQPSVELSNALMKHDDIALILATGGPG--MVKAAYSSGKPAIGVGAGNVP 218 Query: 217 CYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKL 264 +D+ D+ A + K ++G C + ++ + +++ E+ Sbjct: 219 VVIDETADIKRAVASVLMSKTFDNGVVCASEQAVIVVDEVYDEVKERF 266 >1VJT-A nrPDB Length = 483 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 3/72 (4%) Query: 72 EYMIQKLPEWAADEP--VEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL-TIQPMVGA 128 E++ +KLPEW P + +P + P+G + G+W Y +NL T + G Sbjct: 242 EWIEKKLPEWEPKNPWDTQMSPAAMDMYKFYGMLPIGDTVRNGSWKYHYNLETKKKWFGK 301 Query: 129 IAAGNSVVLKPS 140 ++ V +P Sbjct: 302 FGGIDNEVERPK 313 >3L5K-A nrPDB Length = 250 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 5/84 (5%) Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 ++LE A I+ + P++ + K + T++ A +I+H+ H +PF Sbjct: 75 KALEAAQIIIDVLQLPMSKEELVEESQTKLKEVFPTAALMPGAEKLIIHLRKHGIPFALA 134 Query: 406 GNSGMGSYHGKKS-----FETFSH 424 +S S+ K S F FSH Sbjct: 135 TSSRSASFDMKTSRHKEFFSLFSH 158 >5SWI-B nrPDB Length = 717 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 13/26 (50%), Positives = 17/26 (65%) Query: 204 LTPVTLELGGKSPCYVDKNCDLDVAC 229 LTPVT +LGG S + + D+D AC Sbjct: 102 LTPVTSQLGGDSLFHRQSSYDIDKAC 127 >2DMU-A nrPDB Length = 70 Score = 28.5 bits (62), Expect = 6.1, Method: Composition-based stats. Identities = 19/44 (43%), Positives = 23/44 (52%), Gaps = 3/44 (6%) Query: 16 SSGRTRPLQFRIQQLEALQRLIQEQEQELVGA---LAADLHKNE 56 SSGR F +QLEAL+ L QE + VG LA +H E Sbjct: 5 SSGRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARKVHLRE 48 >3IZY-P nrPDB Length = 537 Score = 28.1 bits (61), Expect = 7.3, Method: Compositional matrix adjust. Identities = 26/119 (21%), Positives = 44/119 (36%), Gaps = 33/119 (27%) Query: 137 LKPSELSENMASLLATIIPQYLDKDLYPVIN--------------------GGVPETTEL 176 LKP E E +++L I+ +D + ++N G + E Sbjct: 327 LKPKEKLERDSNVLPVIVKGDVDGSVEAILNVMDTYDASHECELDLVHFGVGDISENDVN 386 Query: 177 LKERFDHILYTGSTGVGKIIMTAAAKHLTPVTL-------------ELGGKSPCYVDKN 222 L E F ++Y + G +I AAK + L EL + PC V+++ Sbjct: 387 LAETFHGVIYGFNVNAGNVIQQLAAKKGVKIKLHKIIYRLIEDLQEELSSRLPCIVEEH 445 >1QP8-A nrPDB Length = 303 Score = 28.1 bits (61), Expect = 7.3, Method: Compositional matrix adjust. Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 8/43 (18%) Query: 272 YGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATR 314 YGE K+ DYGR + + LI+G+KVA G G+ TR Sbjct: 104 YGEKMKRG-DYGRDVE-------IPLIQGEKVAVLGLGEIGTR 138 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3SZA-A nrPDB 605 e-173 1AD3-A nrPDB 557 e-159 5AC2-A nrPDB 554 e-158 5AC0-A nrPDB 554 e-158 4X2Q-A nrPDB 545 e-155 5FHZ-A nrPDB 544 e-155 5L13-A nrPDB 532 e-151 1AG8-A nrPDB 527 e-150 1O9J-A nrPDB 527 e-150 5GT6-A nrPDB 518 e-147 4V3F-A nrPDB 516 e-146 4QGK-A nrPDB 504 e-143 3IWK-A nrPDB 499 e-142 4I8P-A nrPDB 496 e-141 4O6R-A nrPDB 496 e-141 6QAO-A nrPDB 492 e-140 4PZ2-A nrPDB 488 e-138 3IWJ-A nrPDB 486 e-138 4PXL-B nrPDB 486 e-138 4CAZ-A nrPDB 484 e-137 1BPW-A nrPDB 482 e-136 3RHO-A nrPDB 478 e-135 4MPY-A nrPDB 477 e-135 4GO4-A nrPDB 476 e-135 4O5H-A nrPDB 475 e-134 3JZ4-A nrPDB 475 e-134 3R31-A nrPDB 468 e-132 6C43-A nrPDB 462 e-130 6B4R-B nrPDB 461 e-130 5KLK-A nrPDB 460 e-130 2D4E-A nrPDB 460 e-130 4I8Q-A nrPDB 458 e-129 5IUV-A nrPDB 454 e-128 4QYJ-A nrPDB 452 e-127 4F3X-A nrPDB 451 e-127 1WNB-A nrPDB 451 e-127 3I44-A nrPDB 451 e-127 3TY7-A nrPDB 438 e-123 4V6H-A nrPDB 438 e-123 3QAN-A nrPDB 437 e-123 5EUY-A nrPDB 436 e-122 3RHD-A nrPDB 434 e-122 4LIH-A nrPDB 432 e-121 3RJL-A nrPDB 431 e-121 5UR2-A nrPDB 428 e-120 4U3W-A nrPDB 427 e-120 2HG2-A nrPDB 427 e-120 3EK1-A nrPDB 423 e-119 1T90-A nrPDB 421 e-118 3K2W-A nrPDB 421 e-118 3U4J-A nrPDB 421 e-118 5J77-A nrPDB 419 e-117 4ZZ7-A nrPDB 417 e-117 5UCD-A nrPDB 416 e-117 3B4W-A nrPDB 415 e-116 4OGD-A nrPDB 414 e-116 3VZ3-A nrPDB 411 e-115 4JZ6-A nrPDB 411 e-115 6MVR-A nrPDB 411 e-115 5TJR-A nrPDB 410 e-115 6FK3-A nrPDB 406 e-114 2W8P-A nrPDB 406 e-114 2JG7-A nrPDB 405 e-113 2QE0-A nrPDB 404 e-113 4DNG-A nrPDB 403 e-113 4YWE-A nrPDB 403 e-113 5NNO-A nrPDB 403 e-112 5X5U-A nrPDB 401 e-112 3PRL-A nrPDB 399 e-112 2J5N-A nrPDB 398 e-111 3ROS-A nrPDB 396 e-110 3VZ0-A nrPDB 395 e-110 5KF0-A nrPDB 394 e-110 5VBF-A nrPDB 394 e-110 3RH9-A nrPDB 393 e-110 4X0T-A nrPDB 393 e-110 3EFV-A nrPDB 393 e-110 5N5S-A nrPDB 391 e-109 5JRY-A nrPDB 388 e-108 3R64-A nrPDB 388 e-108 5J6B-A nrPDB 384 e-107 4PXN-A nrPDB 376 e-105 4E4G-A nrPDB 376 e-104 5U0M-A nrPDB 372 e-103 6DBB-A nrPDB 358 3e-99 3JU8-A nrPDB 358 5e-99 4KNA-A nrPDB 356 8e-99 4LGZ-A nrPDB 353 1e-97 1UXV-A nrPDB 352 1e-97 4H7N-A nrPDB 352 2e-97 3V9H-A nrPDB 351 3e-97 4I3V-A nrPDB 351 5e-97 4OE4-A nrPDB 318 4e-87 4IDS-A nrPDB 277 9e-75 5DBV-A nrPDB 235 4e-62 1O20-A nrPDB 214 7e-56 3V4C-A nrPDB 209 2e-54 5JFN-A nrPDB 203 1e-52 5UJU-A nrPDB 185 4e-47 Sequences not found previously or not previously below threshold: 1EZ0-A nrPDB 158 5e-39 2Y53-A nrPDB 156 3e-38 5J7I-A nrPDB 131 7e-31 3K9D-A nrPDB 129 3e-30 3MY7-A nrPDB 128 4e-30 6D97-A nrPDB 127 9e-30 4GHK-A nrPDB 115 4e-26 2H5G-A nrPDB 95 7e-20 1VLU-A nrPDB 93 2e-19 4JBE-A nrPDB 90 3e-18 1PDZ-A nrPDB 34 0.097 5MMM-i nrPDB 32 0.45 5X8R-i nrPDB 32 0.59 6C49-A nrPDB 31 0.85 3DOD-A nrPDB 31 0.92 3LOO-A nrPDB 31 0.96 5KQU-A nrPDB 31 1.00 1NNE-A nrPDB 30 2.0 2XH7-A nrPDB 30 2.1 1EWR-A nrPDB 30 2.3 1ZBM-A nrPDB 30 2.3 3QTP-A nrPDB 30 2.5 1EU1-A nrPDB 30 2.6 2WVR-A nrPDB 29 3.0 3C3E-A nrPDB 29 3.1 2OYO-A nrPDB 29 3.5 2IPH-A nrPDB 29 4.1 4BRY-A nrPDB 29 4.6 4FWI-B nrPDB 29 4.7 1WQS-A nrPDB 29 4.9 1MG2-A nrPDB 29 5.3 1QNN-A nrPDB 29 5.4 6B9O-A nrPDB 29 6.3 2FYR-A nrPDB 28 6.7 2R6A-A nrPDB 28 6.9 3UF0-A nrPDB 28 8.9 3GTS-A nrPDB 28 9.2 >3SZA-A nrPDB Length = 469 Score = 605 bits (1560), Expect = e-173, Method: Composition-based stats. Identities = 452/453 (99%), Positives = 453/453 (100%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY Sbjct: 17 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 76 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL Sbjct: 77 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 136 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180 TIQPMVGAIAAGN+VVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER Sbjct: 137 TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 196 Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS Sbjct: 197 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 256 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG Sbjct: 257 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 316 Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK Sbjct: 317 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 376 Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE Sbjct: 377 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 436 Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH Sbjct: 437 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 469 >1AD3-A nrPDB Length = 452 Score = 557 bits (1435), Expect = e-159, Method: Composition-based stats. Identities = 368/450 (81%), Positives = 414/450 (92%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 IS+ VKRAR AF+SG+TR LQFRIQQLEALQR+I E + + GALA+DL KNEW +YYEE Sbjct: 3 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 62 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 V +VLEE++ I++LP+WA DEPV KT QTQQD+LYIHSEPLGVVLVIG WNYPFNLTIQ Sbjct: 63 VAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQ 122 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDH 183 PMVGA+AAGN+V+LKPSE+S +MA LLAT+IPQY+D++LY V+ GGVPETTELLKERFDH Sbjct: 123 PMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDH 182 Query: 184 ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQT 243 I+YTGST VGKI+M AAAKHLTPVTLELGGKSPCYVDK+CDLDVACRRIAWGKFMNSGQT Sbjct: 183 IMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQT 242 Query: 244 CVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKV 303 CVAPDYILCDPSIQNQIVEKLKKSLK+FYGEDAK+SRDYGRII+ RHFQRV GLI+ QKV Sbjct: 243 CVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKV 302 Query: 304 AYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLA 363 A+GGT D ++RYIAPTIL DVDPQSPVMQEEIFGPV+PIVCVRSLEEAIQFINQREKPLA Sbjct: 303 AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLA 362 Query: 364 LYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFS 423 LY+FS+N+KVIKKMIAETSSGGV ANDVIVHIT+ +LPFGGVGNSGMG+YHGKKSFETFS Sbjct: 363 LYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFS 422 Query: 424 HRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453 HRRSCLV+ L+N+E K RYPPSPAKM +H Sbjct: 423 HRRSCLVKSLLNEEAHKARYPPSPAKMPRH 452 >5AC2-A nrPDB Length = 501 Score = 554 bits (1429), Expect = e-158, Method: Composition-based stats. Identities = 126/444 (28%), Positives = 200/444 (45%), Gaps = 20/444 (4%) Query: 2 SKISEAVKRARAAFSS---GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + +AVK AR AF RT R + L L LI+ L + + K N Sbjct: 58 EDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSN 117 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 AY ++ ++ + Y WA P Y EP+GV I WN+P Sbjct: 118 AYLNDLAGCIKTLRYCAG----WADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPL 173 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL 177 + I + A++ GN+VV+KP+E + A +A++I + + ++ G P + Sbjct: 174 VMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAI 233 Query: 178 KER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 D + +TGST VGK+I AA K +L VTLELGGKSPC V + DLD A Sbjct: 234 SSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHH 293 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKE-FYGEDAKKSRDYGRIISARHFQR 293 G F + GQ C+A I + SI ++ V + + K+ G G I + + Sbjct: 294 GVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDK 353 Query: 294 VMGLIE-----GQKVAYGGTGDA-ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 ++ LIE G K+ GG ++ PT+ ++V + + +EEIFGPV I+ +S Sbjct: 354 ILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKS 413 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 L++ I+ N L+ +F+ + + + +G V N + PFGG Sbjct: 414 LDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKM 471 Query: 408 SGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ F ++ ++ V+ Sbjct: 472 SGNGRELGEYGFHEYTEVKTVTVK 495 >5AC0-A nrPDB Length = 501 Score = 554 bits (1427), Expect = e-158, Method: Composition-based stats. Identities = 126/444 (28%), Positives = 202/444 (45%), Gaps = 20/444 (4%) Query: 2 SKISEAVKRARAAFSS---GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + +AVK AR AF RT R + L L LI+ L A + K N Sbjct: 58 EDVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSN 117 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 AY ++ ++ + Y WA P Y SEP+GV I WN+P Sbjct: 118 AYLMDLGGCIKTLRYCAG----WADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPL 173 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL 177 + + + A++ GN+VV+KP+E + A + ++I + + ++ G P + Sbjct: 174 LMFLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAI 233 Query: 178 KER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 D + +TGST VGK+I AA K +L V+LELGGKSPC V + DLD A Sbjct: 234 SSHMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQ 293 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQR 293 G F + GQ C+A + + SI ++ V + + K++ G G I +++ Sbjct: 294 GVFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEK 353 Query: 294 VMGLIE-----GQKVAYGGTGDA-ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 ++ LIE G K+ GG +I PT+ +DV + +EEIFGPV I+ +S Sbjct: 354 ILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKS 413 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 L++ I+ N L+ +F+++ + + SG V N + PFGG Sbjct: 414 LDDVIKRANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVN--CYSVVSAQCPFGGFKM 471 Query: 408 SGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ F ++ ++ ++ Sbjct: 472 SGNGRELGEYGFHEYTEVKTVTIK 495 >4X2Q-A nrPDB Length = 504 Score = 545 bits (1404), Expect = e-155, Method: Composition-based stats. Identities = 122/444 (27%), Positives = 198/444 (44%), Gaps = 20/444 (4%) Query: 2 SKISEAVKRARAAFS---SGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + I +AV+ AR AFS R R + L+ L L++ L + + K Sbjct: 61 ADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQ 120 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 A+Y ++ V++ Y WA P + EP+GV I WN+P Sbjct: 121 AFYVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPL 176 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL 177 + + A+ GN+VV+KP+E + A + +I + + ++ G P + Sbjct: 177 LMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAI 236 Query: 178 KERF--DHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 D I +TGST VGK+I AA + +L VTLELGGKSP + + DLD A + Sbjct: 237 ASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQ 296 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKE-FYGEDAKKSRDYGRIISARHFQR 293 G F N GQ C A I + SI + V + + K G + + G I + + + Sbjct: 297 GVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNK 356 Query: 294 VMGLI-----EGQKVAYGGTGDA-ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 ++ LI EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++ Sbjct: 357 ILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKT 416 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 ++E I+ N + L +F+++ + + +G V N + PFGG Sbjct: 417 MDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN--CYNALNAQSPFGGFKM 474 Query: 408 SGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ +S ++ V+ Sbjct: 475 SGNGREMGEFGLREYSEVKTVTVK 498 >5FHZ-A nrPDB Length = 529 Score = 544 bits (1403), Expect = e-155, Method: Composition-based stats. Identities = 119/443 (26%), Positives = 203/443 (45%), Gaps = 20/443 (4%) Query: 3 KISEAVKRARAAFSS---GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNA 59 + +AV+ A+ AF R R + L L L++ L D K +A Sbjct: 87 DVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHA 146 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 ++ ++ + + Y WA + P + EP+GV I WN+P Sbjct: 147 FFIDLEGCIRTLRYFAG----WADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLL 202 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK 178 + + + A+ GN++VLKP+E + A L ++I + + ++ G P + Sbjct: 203 MLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAIS 262 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 235 + I +TGST VGK++ AA++ +L VTLELGGK+PC V + DLD+A G Sbjct: 263 SHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQG 322 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKEFYGEDAKKSRDYGRIISARHFQRV 294 F N GQ C A + + + ++ V + + + K G+ + G I + F ++ Sbjct: 323 VFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKI 382 Query: 295 MGLIE-----GQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 + LIE G K+ GG+ + +I PT+ ++V + +EEIFGPV PI+ +S+ Sbjct: 383 LELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSI 442 Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408 EE I+ N + L +F+ N K+ + SG V N + PFGG S Sbjct: 443 EEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKMS 500 Query: 409 GMGSYHGKKSFETFSHRRSCLVR 431 G G G+ + ++ ++ ++ Sbjct: 501 GNGRELGEYALAEYTEVKTVTIK 523 >5L13-A nrPDB Length = 517 Score = 532 bits (1370), Expect = e-151, Method: Composition-based stats. Identities = 119/444 (26%), Positives = 191/444 (43%), Gaps = 20/444 (4%) Query: 2 SKISEAVKRARAAFSS---GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + +AVK ARAAF R R + L L LI+ L D K Sbjct: 74 EDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVI 133 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 +Y ++ VL+ + Y WA + P Y EP+GV I WN+P Sbjct: 134 SYLVDLDMVLKCLRYYAG----WADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPL 189 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL 177 + + A+A GN VV+K +E + A +A +I + + ++ G P + Sbjct: 190 LMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAI 249 Query: 178 KER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 D + +TGST +G++I AA +L VTLELGGKSP + + D+D A + + Sbjct: 250 ASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHF 309 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQR 293 F N GQ C A I ++ VE+ + ++ G + G + F++ Sbjct: 310 ALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKK 369 Query: 294 VMGLI-----EGQKVAYGGT-GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 ++G I EG K+ GG +I PT+ DV + +EEIFGPV+ I+ ++ Sbjct: 370 ILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKT 429 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 +EE + N LA +F+ + + +G V N + PFGG Sbjct: 430 IEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYKM 487 Query: 408 SGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ + ++ ++ V+ Sbjct: 488 SGSGRELGEYGLQAYTEVKTVTVK 511 >1AG8-A nrPDB Length = 499 Score = 527 bits (1358), Expect = e-150, Method: Composition-based stats. Identities = 125/444 (28%), Positives = 192/444 (43%), Gaps = 20/444 (4%) Query: 2 SKISEAVKRARAAFSS---GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + + AVK ARAAF R R + L L LI+ L D K Sbjct: 56 ADVDRAVKAARAAFQLGSPWRRMDASERGRLLNRLADLIERDRTYLAALETLDNGKPYII 115 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 +Y ++ VL+ + Y WA + P Y EP+GV I WN+P Sbjct: 116 SYLVDLDMVLKCLRYYAG----WADKYHGKTIPIDGDYFSYTRHEPVGVCGQIIPWNFPL 171 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL 177 + + A+A GN VV+K +E + A +A +I + + VI G P + Sbjct: 172 LMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNVIPGFGPTAGAAI 231 Query: 178 KER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 D + +TGST VG +I AA K +L VTLE+GGKSP + + D+D A + + Sbjct: 232 ASHEDVDKVAFTGSTEVGHLIQVAAGKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAHF 291 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQR 293 F N GQ C A I + VE+ + ++ G + G + F++ Sbjct: 292 ALFFNQGQCCCAGSRTFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKK 351 Query: 294 VMGLI-----EGQKVAYGGTGDA-ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 V+G I EG K+ GG A +I PT+ D+ + +EEIFGPV+ I+ +S Sbjct: 352 VLGYIKSGKEEGLKLLCGGGAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKFKS 411 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 +EE + N + LA +F+ + + +G V N + PFGG Sbjct: 412 MEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYKL 469 Query: 408 SGMGSYHGKKSFETFSHRRSCLVR 431 SG G G+ + ++ ++ VR Sbjct: 470 SGSGRELGEYGLQAYTEVKTVTVR 493 >1O9J-A nrPDB Length = 501 Score = 527 bits (1357), Expect = e-150, Method: Composition-based stats. Identities = 123/450 (27%), Positives = 201/450 (44%), Gaps = 20/450 (4%) Query: 2 SKISEAVKRARAAFSS---GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + +AVK AR AF RT R Q + L LI+ L + + K + Sbjct: 58 EDVDKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFAS 117 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 AY ++ Y ++ + Y WA P + Y EP+GV +I WN P Sbjct: 118 AYLMDLDYCIKALRYCAG----WADKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNAPM 173 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL 177 L + A+ GN+V++KP+E + A +A++I + + ++ G P + Sbjct: 174 ILLACKIGPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAI 233 Query: 178 KER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 D + +TGST VGK+I AAAK +L VTLELG K+PC V + DLD A Sbjct: 234 SSHMDVDKVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQ 293 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQR 293 G F N GQ+C+A + + +I ++ V++ + K++ G ++G I+ + Sbjct: 294 GVFTNQGQSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQHNK 353 Query: 294 VMGLIE-----GQKVAYGGTGDA-ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 +M LIE G K+ GG +I PT+ ++V + +EEIFGPV I+ +S Sbjct: 354 IMELIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKS 413 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 L+E I+ N L +F+ + + + +G V N P GG Sbjct: 414 LDEVIKRANNTYYGLVAGVFTKDLDKAVTVSSALQAGTVWVN--CYLAASAQSPAGGFKM 471 Query: 408 SGMGSYHGKKSFETFSHRRSCLVRPLMNDE 437 SG G G+ ++ ++ ++ + Sbjct: 472 SGHGREMGEYGIHEYTEVKTVTMKISEKNS 501 >5GT6-A nrPDB Length = 508 Score = 518 bits (1335), Expect = e-147, Method: Composition-based stats. Identities = 127/442 (28%), Positives = 197/442 (44%), Gaps = 18/442 (4%) Query: 2 SKISEAVKRARAAFSS--GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNA 59 I AVK AR+AF S R + L LI+E +EL A D K A Sbjct: 71 EDIDAAVKAARSAFESGPWAEMTTAERAHLIYKLADLIEEHREELAQLEALDNGKPYQVA 130 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 +++ +E Y W + P ++ Y EP+GVV I WN+P Sbjct: 131 LDDDISATVENYRYYAG----WTTKIIGQTIPISKDYLNYTRHEPVGVVGQIIPWNFPLV 186 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK 178 ++ M A+A G ++VLKP+E + A + + + + G PE + Sbjct: 187 MSSWKMGAALATGCTIVLKPAEQTPLSLLYAAKLFKEAGFPNGVVNFVPGFGPEAGAAIV 246 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 D + +TGST GK IM +A+ + VTLELGGKSP + ++ DL+ A G Sbjct: 247 NHHDIDKVAFTGSTVTGKYIMRQSAEMIKHVTLELGGKSPNIILEDADLEEAINGAFQGI 306 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQRVM 295 N GQ C A + +V+ L K G +K + G ++S + +RV+ Sbjct: 307 MYNHGQNCSAGSRVFVHRKHYETVVDALVKMANNVKLGAGMEKETEMGPLVSKKQQERVL 366 Query: 296 GLIE-----GQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 IE G VA GG ++ PT+ TDV +++EEIFGPV+ ++ S E Sbjct: 367 NYIEQGKKEGATVAAGGERALEKGYFVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDSTE 426 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 E I+ N LA +++ N K ++ + +G V ND ++ + PFGG SG Sbjct: 427 EVIERANNSSYGLAAGVWTQNIKTGHQVANKLKAGTVWIND--YNLENAAAPFGGYKQSG 484 Query: 410 MGSYHGKKSFETFSHRRSCLVR 431 +G G + + ++ +S V Sbjct: 485 IGRELGSYALDNYTEVKSVWVN 506 >4V3F-A nrPDB Length = 497 Score = 516 bits (1329), Expect = e-146, Method: Composition-based stats. Identities = 128/458 (27%), Positives = 200/458 (43%), Gaps = 19/458 (4%) Query: 2 SKISEAVKRARAAFSS--GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNA 59 + AV AR AF R L A+ I E++ V D K A Sbjct: 45 EDVEVAVVAARRAFRRNNWSATSGAHRATYLRAIAAKITEKKDHFVKLETIDSGKPFDEA 104 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 ++ V EY + + T ++ + ++ +PLGVV +I WNYP Sbjct: 105 VL-DIDDVASCFEYFAGQAEALDGKQKAPVTLPMERFKSHVLRQPLGVVGLISPWNYPLL 163 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELLK 178 + + A+AAG + VLKPSEL+ + + L + ++ G P+ L Sbjct: 164 MATWKIAPALAAGCTAVLKPSELASVTCLEFGEVCNEVGLPPGVLNILTGLGPDAGAPLV 223 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 D I +TGS+ G +M +AA+ + PVTLELGGKSP V ++ D+D +G Sbjct: 224 SHPDVDKIAFTGSSATGSKVMASAAQLVKPVTLELGGKSPIVVFEDVDIDKVVEWTIFGC 283 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYG-EDAKKSRDYGRIISARHFQRVM 295 F +GQ C A +L SI + V+KL K K + ++ G +IS + ++M Sbjct: 284 FWTNGQICSATSRLLVHESIAAEFVDKLVKWTKNIKISDPFEEGCRLGPVISKGQYDKIM 343 Query: 296 GLI-----EGQKVAYGGTGDA---ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 I EG + YGG+ YI PTI+TD+ + +EE+FGPVL + S Sbjct: 344 KFISTAKSEGATILYGGSRPEHLKKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTFSS 403 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 +EAI N E LA +FS++ + +++ G V N P+GG+ Sbjct: 404 EDEAIALANDTEYGLAAAVFSNDLERCERITKALEVGAVWVN--CSQPCFVQAPWGGIKR 461 Query: 408 SGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPP 445 SG G G+ + + + + ++DE P Sbjct: 462 SGFGRELGEWGIQNYLNIKQVTQD--ISDEPWGWYKSP 497 >4QGK-A nrPDB Length = 461 Score = 504 bits (1299), Expect = e-143, Method: Composition-based stats. Identities = 297/439 (67%), Positives = 377/439 (85%) Query: 8 VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67 V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V Sbjct: 6 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 65 Query: 68 LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127 L EI++M++ LPEW +PV+K T DE YI +PLGVVL+IG WNYPF LTIQP++G Sbjct: 66 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 125 Query: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187 AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT Sbjct: 126 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 185 Query: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247 G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP Sbjct: 186 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 245 Query: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307 DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG Sbjct: 246 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 305 Query: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367 D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F Sbjct: 306 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 365 Query: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427 S N K+IK+MI ETSSGGV NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R Sbjct: 366 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 425 Query: 428 CLVRPLMNDEGLKVRYPPS 446 CL++ L + K+RYPP+ Sbjct: 426 CLLKSLKREGANKLRYPPN 444 >3IWK-A nrPDB Length = 503 Score = 499 bits (1286), Expect = e-142, Method: Composition-based stats. Identities = 130/462 (28%), Positives = 204/462 (44%), Gaps = 22/462 (4%) Query: 2 SKISEAVKRARAAFSS-----GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNE 56 + AV A+ A S R + L A+ I+E++ EL + D K Sbjct: 45 EDVDLAVDAAKRAISRKNGRDWSAASGSLRARYLRAIAAKIKEKKDELGKLESIDCGKPL 104 Query: 57 WNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNY 116 A ++ V+ EY E + + + + YI EP+GVV +I WNY Sbjct: 105 EEAL-ADLDDVVACFEYYAGLAEELDSKQKAPISLPMDTFKSYILKEPIGVVALITPWNY 163 Query: 117 PFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTE 175 PF + + A+AAG + +LKPSEL+ L I + L + + ++ G E Sbjct: 164 PFLMATWKIAPALAAGCAAILKPSELASVTCLELGEICKEVGLPRGVLNIVTGLGHEAGA 223 Query: 176 LLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 L D I +TGS+ G IMT AA+ + PV+LELGGKSP V ++ DLD Sbjct: 224 SLASHPDVDKISFTGSSATGSKIMTTAAQLVKPVSLELGGKSPIVVFEDVDLDKVAEWTV 283 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYG-EDAKKSRDYGRIISARHFQ 292 +G F +GQ C A ++ SI + V+KL K + + ++ G I+S ++ Sbjct: 284 FGCFFTNGQICSATSRLIVHESIAVEFVDKLVKWAENIKISDPLEEGCRLGPIVSEAQYK 343 Query: 293 RVMGLI-----EGQKVAYGGTGDA---ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVC 344 +V+ I EG + GG ++ PTI+TDV + +EE+FGPVL + Sbjct: 344 KVLNCISSAKSEGATILTGGRRPEHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLAVKT 403 Query: 345 VRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGG 404 + EEAI N L + S++ + +++ +G V N + P+GG Sbjct: 404 FSTEEEAINLANDTHYGLGSAVMSNDLERCERLSKALQAGIVWIN--CAQPSFIQAPWGG 461 Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPS 446 + SG G G+ E + + +DE PPS Sbjct: 462 IKRSGFGRELGEWGLENYLSVKQVT--RYTSDEPWGWYQPPS 501 >4I8P-A nrPDB Length = 520 Score = 496 bits (1277), Expect = e-141, Method: Composition-based stats. Identities = 117/441 (26%), Positives = 193/441 (43%), Gaps = 17/441 (3%) Query: 18 GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQK 77 P R + L A+ + E++ EL A D K A + ++ V EY + Sbjct: 83 WARAPGAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAW-DMDDVAGCFEYFADQ 141 Query: 78 LPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVL 137 + + + + ++ EP+GVV +I WNYP + + A+AAG + VL Sbjct: 142 AEALDKRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVL 201 Query: 138 KPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELLKER--FDHILYTGSTGVGK 194 KPSEL+ LA I + L + ++ G P+ L D + +TGS GK Sbjct: 202 KPSELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETGK 261 Query: 195 IIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDP 254 IM +AA + PVTLELGGKSP V + D+D A +G F +GQ C A +L Sbjct: 262 KIMASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLIHT 321 Query: 255 SIQNQIVEKLKKSLKEFYG-EDAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGT 308 I + E++ K + ++ G ++S ++++ I +G + GG Sbjct: 322 KIAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGGV 381 Query: 309 GD---AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALY 365 +I PTI+TD+ + +EE+FGPVL + + +EAI+ N + LA Sbjct: 382 RPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLAGA 441 Query: 366 MFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHR 425 + S + + +++ E +G + N P+GG SG G G+ + + Sbjct: 442 VISGDRERCQRLSEEIDAGCIWVN--CSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLSV 499 Query: 426 RSCLVRPLMNDEGLKVRYPPS 446 + ++DE PS Sbjct: 500 KQVT--EYISDEPWGWYQSPS 518 >4O6R-A nrPDB Length = 496 Score = 496 bits (1277), Expect = e-141, Method: Composition-based stats. Identities = 117/443 (26%), Positives = 182/443 (41%), Gaps = 20/443 (4%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 + AV A AF + P R + L L I+ + L + D ++ Sbjct: 49 DVDLAVDAATRAFPAWSAMPAAERGRLLLRLADAIEANTEALAQLESLDTGHPIRDSRAL 108 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 +V Y A P Y+ P+GVV I WN+P T Sbjct: 109 DVPRTAACFRYFGG----MADKLQGSVIPVDTGFLNYVQRAPIGVVGQIVPWNFPLMFTS 164 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELLKER- 180 M A+AAGN+VVLKPSE++ + ++ + + ++ G + L E Sbjct: 165 WKMGPALAAGNTVVLKPSEITPLSTLRIVELMAEVGFPAGVVNIVPGYGHTAGQRLAEHP 224 Query: 181 -FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 I +TGST G+ I+ A+ +L V LELGGK V + +LD A AW F N Sbjct: 225 GVGKIAFTGSTATGRRIVEASQGNLKRVQLELGGKGANIVFDDANLDAAINGAAWAIFHN 284 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298 GQ C+A ++ I + +E+ G + + G + S +H RV+ + Sbjct: 285 QGQACIAGSRLVLHERIADAFLERFVALASSIRIGNPLDPNTEMGPLTSKQHLDRVLSYV 344 Query: 299 E-----GQKVAYGGTGD-----AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 + G +V GG+ A Y+ PTI+ V QEE+FGP + ++ S Sbjct: 345 DVAREQGGRVLTGGSAPQDPALANGYYVRPTIVEAKHATDRVAQEEVFGPFVTVLRFGSD 404 Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408 +EA+ N E L +++++ +M A +G N PFGGVG S Sbjct: 405 DEALAIANATEYGLGSGLWTNDLSRAHRMAARIDAGMCWIN--CYKRVNPGSPFGGVGKS 462 Query: 409 GMGSYHGKKSFETFSHRRSCLVR 431 G G G ++ ++ RS V Sbjct: 463 GYGREMGFEAMHDYTEARSVWVN 485 >6QAO-A nrPDB Length = 508 Score = 492 bits (1268), Expect = e-140, Method: Composition-based stats. Identities = 126/444 (28%), Positives = 208/444 (46%), Gaps = 24/444 (5%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 +++ AV+ A+AAF + R + L R+I+E+E E+ + K+ + A Sbjct: 64 EVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL- 122 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 ++ + +EY AA E Y EPLGV + IG WNYPF + Sbjct: 123 DIDISWQCLEYYAG----LAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIAS 178 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER- 180 A+A GN++V KPS + A LLA I + + L+ V+ GG T + L + Sbjct: 179 WKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHP 237 Query: 181 -FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 + +TGS G IM +AK + PVTLELGGKSP + +CD++ A + F+ Sbjct: 238 DVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLT 297 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298 GQ C + I ++ E++ K + G+ + G +I+ H +RV+G + Sbjct: 298 QGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV 357 Query: 299 -----EGQKVAYGG-------TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346 +G KV GG Y+ P +LT+ ++EEIFGPV+ I+ Sbjct: 358 KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFD 417 Query: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406 + E ++ N LA +F+ + + +++AE +G N+ +++ LPFGG Sbjct: 418 TEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYK 475 Query: 407 NSGMGSYHGKKSFETFSHRRSCLV 430 SG G +G+ + E +S ++ V Sbjct: 476 KSGFGRENGRVTIEYYSQLKTVCV 499 >4PZ2-A nrPDB Length = 534 Score = 488 bits (1256), Expect = e-138, Method: Composition-based stats. Identities = 123/444 (27%), Positives = 195/444 (43%), Gaps = 22/444 (4%) Query: 2 SKISEAVKRARAAFS--SGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNA 59 + AV+ ARAAF R + + L L++E EL + D K+ Sbjct: 88 EDVDLAVRAARAAFDHGEWPRMSGSERGRIMARLADLVEEHAGELAALESLDAGKHPAVT 147 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 +V + Y A E Q + + EPLGV VI WN+P Sbjct: 148 RAVDVGNAAGSLRYFAGA----ADKIHGETLKMPGQFQGHTLREPLGVAGVIIPWNFPST 203 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK 178 + + A+AAG ++V+KP+E + A LA + Q + + V+ G P L Sbjct: 204 MFAVKVAPALAAGCALVVKPAEQTPLSALYLAQLAKQAGVPDGVINVVPGFGPTAGAALA 263 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 235 D + +TGST VG++IM A+A+ +L PV LELGGKSP V + DLD+A Sbjct: 264 SHMDVDMVSFTGSTEVGRLIMKASAESNLKPVYLELGGKSPLIVFDDADLDMAVELAVGA 323 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDA--KKSRDYGRIISARHFQR 293 F N G+ CVA + + ++ E+L + ++ + D D G + ++R Sbjct: 324 SFFNKGEACVAASRVYVQERVYDRFEERLAERMRSWVVGDPFSDPRADQGPQVDKAQYER 383 Query: 294 VMGLI-----EGQKVAYGGTG---DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 V+ I EG + GG + YI PT+ T+V + +EEIFGPV+ ++ Sbjct: 384 VLSYIDHGKREGATLLTGGRPCAPEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKF 443 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 +++EEAI N L + + + V +++ +G V N PFGG Sbjct: 444 KTVEEAIARANDTRYGLGAGVVTRDLDVANRVVRSVRAGVVWVN--CYFAMGSDCPFGGR 501 Query: 406 GNSGMGSYHGKKSFETFSHRRSCL 429 SG G G + + + +S + Sbjct: 502 KMSGFGKDEGMHALDKYLAVKSVV 525 >3IWJ-A nrPDB Length = 503 Score = 486 bits (1252), Expect = e-138, Method: Composition-based stats. Identities = 122/462 (26%), Positives = 206/462 (44%), Gaps = 22/462 (4%) Query: 2 SKISEAVKRARAAFSS-----GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNE 56 + AV A+ A + T R + L A+ + E++ EL + D K Sbjct: 45 EDVDVAVAAAKTALTRNKGADWATASGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPL 104 Query: 57 WNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNY 116 A + ++ V EY + A + + + ++ EP+GVV +I WNY Sbjct: 105 DEAAW-DIDDVAGCFEYYADLAEKLDARQKAPVSLPMDTFKSHVLREPIGVVGLITPWNY 163 Query: 117 PFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTE 175 P + + A+AAG + +LKPSEL+ L I + L + ++ G PE Sbjct: 164 PMLMATWKVAPALAAGCAAILKPSELASLTCLELGEICKEVGLPPGVLNILTGLGPEAGA 223 Query: 176 LLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 L D + +TGS+ G IMTAAA+ + PV+LELGGKSP V ++ DLD A Sbjct: 224 PLATHPDVDKVAFTGSSATGSKIMTAAAQLVKPVSLELGGKSPLVVFEDVDLDKAAEWAI 283 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYG-EDAKKSRDYGRIISARHFQ 292 +G F +GQ C A ++ SI + + ++ K +K + ++ G ++S ++ Sbjct: 284 FGCFWTNGQICSATSRLILHESIATEFLNRIVKWIKNIKISDPLEEGCRLGPVVSEGQYE 343 Query: 293 RVMGLI-----EGQKVAYGGTGDA---ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVC 344 +++ + EG + GG+ +I PTI+TDV + +EE+FGPVL + Sbjct: 344 KILKFVSNAKSEGATILTGGSRPEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCVKT 403 Query: 345 VRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGG 404 + EEAI N L + S++ + +++ +G V N P+GG Sbjct: 404 FSTEEEAIDLANDTVYGLGAAVISNDLERCERVTKAFKAGIVWVN--CSQPCFTQAPWGG 461 Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPS 446 V SG G G+ + + + +++E PP+ Sbjct: 462 VKRSGFGRELGEWGLDNYLSVKQVT--QYISEEPWGWYQPPA 501 >4PXL-B nrPDB Length = 517 Score = 486 bits (1252), Expect = e-138, Method: Composition-based stats. Identities = 128/447 (28%), Positives = 195/447 (43%), Gaps = 20/447 (4%) Query: 2 SKISEAVKRARAAFSS--GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNA 59 + + AVK AR AF + R + L LI E +EL D K Sbjct: 74 ADVDLAVKAAREAFDNGPWPRMTGYERGRILHRFADLIDEHVEELAALDTVDAGKLFAVG 133 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 ++ + Y A Q+ Y EP+GVV I WNYP Sbjct: 134 KARDIPGAAHLLRYYAGA----ADKVHGATLKMAQRMHGYTLKEPVGVVGHIVPWNYPTT 189 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK 178 + + A+AAG +VV+KP+E + A A + + + + V+ G P + Sbjct: 190 MFFFKVGPALAAGCAVVVKPAEQTPLSALFYAHLAREAGVPAGVLNVVPGFGPTAGAAVA 249 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 235 D + +TGST VG+++M AAA+ +L PV+LELGGKSP V + DLD+A + + Sbjct: 250 AHMDVDKVSFTGSTEVGRLVMRAAAESNLKPVSLELGGKSPVIVFDDADLDMAVNLVNFA 309 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKEFYGEDAKKSRDYGRIISARHFQRV 294 + N G+ CVA I I ++ V+K + + K G+ S G + +++V Sbjct: 310 TYTNKGEICVAGTRIYVQEGIYDEFVKKAAELASKSVVGDPFNPSVSQGPQVDKDQYEKV 369 Query: 295 MGLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 + I EG + GG YI PTI TDV + Q+EIFGPV+ ++ +++ Sbjct: 370 LRYIDIGKREGATLVTGGKPCGDKGYYIEPTIFTDVKDDMTIAQDEIFGPVMALMKFKTV 429 Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408 EE IQ N LA + + N V + +G + N PFGG S Sbjct: 430 EEVIQKANNTRYGLAAGIVTKNIDVANTVSRSIRAGAIWIN--CYFAFDPDAPFGGYKMS 487 Query: 409 GMGSYHGKKSFETFSHRRSCLVRPLMN 435 G G G + + + ++ V PL N Sbjct: 488 GFGKDMGMDALDKYLQTKTV-VTPLYN 513 >4CAZ-A nrPDB Length = 490 Score = 484 bits (1246), Expect = e-137, Method: Composition-based stats. Identities = 120/444 (27%), Positives = 197/444 (44%), Gaps = 21/444 (4%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + AV+ A R + L +++E+ EL D K Sbjct: 44 EDVERAVQSAVEGQKVWAAMTAMQRSRILRRAVDILRERNDELAALETLDTGKPLAETRS 103 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 ++V + +EY +P E+ P + +Y EPLGVV IG WNYP + Sbjct: 104 VDIVTGADVLEYYAGLVPAIEG----EQIPLRETSFVYTRREPLGVVAGIGAWNYPVQIA 159 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER 180 + A+AAGN+++ KPSE++ A LA I + + ++ V+ G E + L E Sbjct: 160 LWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYTEAGVPDGVFNVLTGSGREVGQWLTEH 219 Query: 181 --FDHILYTGSTGVGKIIMTAAAKH-LTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKF 237 + I +TG T GK +M +A+ L VT+ELGGKSP + + DLD A F Sbjct: 220 PLIEKISFTGGTSTGKKVMASASSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANF 279 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMG 296 +SGQ C + S Q + K+ + ++ G+ ++ ++G ++S H + V+G Sbjct: 280 FSSGQVCTNGTRVFIHRSQQARFEAKVLERVQRIRLGDPQDENTNFGPLVSFPHMESVLG 339 Query: 297 LIEG-----QKVAYGGTGD-----AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346 IE ++ GG Y+APT+ TD +++EEIFGPV+ I+ Sbjct: 340 YIESGKAQKARLLCGGERVTDGAFGKGAYVAPTVFTDCRDDMTIVREEIFGPVMSILVYD 399 Query: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406 +EAI+ N E LA + + + + I +G N + +P GG Sbjct: 400 DEDEAIRRANDTEYGLAAGVVTQDLARAHRAIHRLEAGICWIN--TWGESPAEMPVGGYK 457 Query: 407 NSGMGSYHGKKSFETFSHRRSCLV 430 SG+G +G + ++ +S V Sbjct: 458 QSGVGRENGLTTLAHYTRIKSVQV 481 >1BPW-A nrPDB Length = 503 Score = 482 bits (1242), Expect = e-136, Method: Composition-based stats. Identities = 121/445 (27%), Positives = 196/445 (44%), Gaps = 24/445 (5%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 ++ +AV+ A+AA+ R + + R+I+E+ + + K A Y Sbjct: 58 EEVDQAVQSAQAAYLKWSKMAGIERSRVMLEAARIIRERRDNIAKLEVINNGKTITEAEY 117 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 ++ + IEY P + + Y EPLGV I WNYPF + Sbjct: 118 -DIDAAWQCIEYYAGLAPTLSG----QHIQLPGGAFAYTRREPLGVCAGILAWNYPFMIA 172 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER 180 A+A GN+VV KPS ++ +LA I + + L V+ GG ET LL Sbjct: 173 AWKCAPALACGNAVVFKPSPMTPVTGVILAEIFHEAGVPVGLVNVVQGGA-ETGSLLCHH 231 Query: 181 --FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 + +TGS GK +M +AK + VTLELGGKSP + K+C+L+ A R F+ Sbjct: 232 PNVAKVSFTGSVPTGKKVMEMSAKTVKHVTLELGGKSPLLIFKDCELENAVRGALMANFL 291 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGL 297 GQ C + I Q +E++ K K G+ G +IS +V+G Sbjct: 292 TQGQVCTNGTRVFVQREIMPQFLEEVVKRTKAIVVGDPLLTETRMGGLISKPQLDKVLGF 351 Query: 298 I-----EGQKVAYGGTG-------DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 + EG +V GG +++P +L + ++EEIFGPV+ ++ Sbjct: 352 VAQAKKEGARVLCGGEPLTPSDPKLKNGYFMSPCVLDNCRDDMTCVKEEIFGPVMSVLPF 411 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 + EE +Q N LA +F+ + ++ A +G N I+ +PFGG Sbjct: 412 DTEEEVLQRANNTTFGLASGVFTRDISRAHRVAANLEAGTCYIN--TYSISPVEVPFGGY 469 Query: 406 GNSGMGSYHGKKSFETFSHRRSCLV 430 SG G +G+ + + +S ++ +V Sbjct: 470 KMSGFGRENGQATVDYYSQLKTVIV 494 >3RHO-A nrPDB Length = 517 Score = 478 bits (1230), Expect = e-135, Method: Composition-based stats. Identities = 107/444 (24%), Positives = 198/444 (44%), Gaps = 17/444 (3%) Query: 1 MSKISEAVKRARAAFSS--GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 +S + +AV A+ AF + + R + L L ++++ ++EL A D Sbjct: 73 VSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTL 132 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 A V ++ Y + + ++ EP+GV ++ WNYP Sbjct: 133 ALKTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPL 192 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177 + +AAGN+VV+KP++++ A A + + + K + ++ G + L Sbjct: 193 MMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRL 252 Query: 178 KER--FDHILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 + I +TGST VGK IM + A ++ V+L+LGGKSP + +CDL+ A + Sbjct: 253 SDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLQLGGKSPLIIFADCDLNKAVQMGMS 312 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293 F N G+ C+A + + SI NQ V+K+ + +++ G ++ ++G H ++ Sbjct: 313 SVFFNKGENCIAAGRLFVEESIHNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRK 372 Query: 294 VM-----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV-- 345 ++ G+ EG + GG + PT+ TDV+ + +EE FGP++ I Sbjct: 373 LVEYCQRGVKEGATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFAD 432 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 ++ + N E LA +F+ + + + +G V N + T + PFGG Sbjct: 433 GDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFIN--TYNKTDVAAPFGGF 490 Query: 406 GNSGMGSYHGKKSFETFSHRRSCL 429 SG G G+ + + ++ Sbjct: 491 KQSGFGKDLGEAALNEYLRIKTVT 514 >4MPY-A nrPDB Length = 520 Score = 477 bits (1227), Expect = e-135, Method: Composition-based stats. Identities = 116/444 (26%), Positives = 194/444 (43%), Gaps = 22/444 (4%) Query: 2 SKISEAVKRARAAFSS--GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNA 59 A+ AR AF S + R +++ A+ I+E + L D K + Sbjct: 70 EDAERAILAARRAFESGEWSQETAETRGKKVRAIADKIKEHREALARLETLDTGKTLEES 129 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 Y ++ + Y + + P T+ I EP+GVV I WNYP Sbjct: 130 Y-ADMDDIHNVFMYFAGLADKDGGEMIDSPIPDTESK---IVKEPVGVVTQITPWNYPLL 185 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELLK 178 + A+A G S+V+KPSE++ + ++ + K +I G E +++ Sbjct: 186 QASWKIAPALATGCSLVMKPSEITPLTTIRVFELMEEVGFPKGTINLILGAGSEVGDVMS 245 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 D + +TG GK IM AA ++T + LELGGK+P + + D ++A + G Sbjct: 246 GHKEVDLVSFTGGIETGKHIMKNAANNVTNIALELGGKNPNIIFDDADFELAVDQALNGG 305 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQRVM 295 + ++GQ C A IL SI+++ + L +K+ G + G +IS H ++ Sbjct: 306 YFHAGQVCSAGSRILVQNSIKDKFEQALIDRVKKIKLGNGFDADTEMGPVISTEHRNKIE 365 Query: 296 GLI-----EGQKVAYGGTGDAA-----TRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 + EG +A GG + PT++T+ D ++QEE+FGPV+ + Sbjct: 366 SYMDVAKAEGATIAVGGKRPDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGF 425 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 + +EAIQ N LA +FS + +++ + G V ND H P+GG Sbjct: 426 ETEQEAIQLANDSIYGLAGAVFSKDIGKAQRVANKLKLGTVWINDF--HPYFAQAPWGGY 483 Query: 406 GNSGMGSYHGKKSFETFSHRRSCL 429 SG+G GK+ E + + L Sbjct: 484 KQSGIGRELGKEGLEEYLVSKHIL 507 >4GO4-A nrPDB Length = 495 Score = 476 bits (1226), Expect = e-135, Method: Composition-based stats. Identities = 120/434 (27%), Positives = 185/434 (42%), Gaps = 21/434 (4%) Query: 12 RAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEI 71 + AF + R + L L I+E +EL + + ++ +V Sbjct: 50 KRAFPAWSALGAAERGRLLLKLADRIEECSEELAQLESLNTGHPIRDSRGLDVPRTAACF 109 Query: 72 EYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAA 131 Y A P Y+ +P+GVV I WN+P T M A+AA Sbjct: 110 RYFGG----MADKIEGSVIPVDAGFLNYVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAA 165 Query: 132 GNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELLKERFD--HILYTG 188 GN++V+KPSE++ + ++ + K + V+ G + L E D I +TG Sbjct: 166 GNTIVIKPSEITPLSTLRIVELMTEVGFPKGVVNVVPGYGHTAGQALAEHLDVGKIAFTG 225 Query: 189 STGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPD 248 ST G+ I+ A+ +L + LELGGK V ++ +++ A AW F N GQ C+A Sbjct: 226 STATGRRIVEASKSNLKRIQLELGGKGANIVFEDANIEAAVNGAAWAIFHNQGQACIAGS 285 Query: 249 YILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE-----GQK 302 ++ I +Q +E+ K G+ + G + SA RV+ I+ G K Sbjct: 286 RLILHKDIADQFLERFIALAKSIRLGDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGK 345 Query: 303 VAYGGTGD-----AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQ 357 V GG A Y+ PT++ + PQ V QEE+FGP + +V S EEA+ N Sbjct: 346 VLAGGKAPDDKALANGFYVEPTVV-EAKPQDRVCQEEVFGPFVTVVRFSSDEEALAIANN 404 Query: 358 REKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKK 417 E L +++ N KM +G N PFGGVG SG G G + Sbjct: 405 TEYGLGSGLWTQNLARAHKMAHAIHAGMCWIN--CYKRVSPGSPFGGVGQSGYGREMGFE 462 Query: 418 SFETFSHRRSCLVR 431 + ++ RS V Sbjct: 463 AIHDYTEARSVWVN 476 >4O5H-A nrPDB Length = 511 Score = 475 bits (1224), Expect = e-134, Method: Composition-based stats. Identities = 116/426 (27%), Positives = 185/426 (43%), Gaps = 14/426 (3%) Query: 18 GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQK 77 RT R + + L LI+ +EL + D K A +V + YM Sbjct: 86 WRTAKTTDRERLMLVLADLIEANARELAEIESLDNGKPVMVAQGLDVAMAAQCFRYMAGW 145 Query: 78 LPEWAADEPVEKTPQTQQDEL--YIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSV 135 + P E+ Y EP+GVV I WN+P + + A+A G +V Sbjct: 146 ATKIEGSVIDAGMPYLPDSEIFAYTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTV 205 Query: 136 VLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL--KERFDHILYTGSTGV 192 VLKP+E + A L +I + ++ G L R D I +TGST Sbjct: 206 VLKPAEDTPLSALRLGELIQAAGFPDGVVNIVTGYGHTAGAALSRDPRIDKIAFTGSTQT 265 Query: 193 GKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILC 252 GK I AA ++T ++LELGGKSP V + DLD A + +A F N GQ C A Sbjct: 266 GKTIGHAALDNMTRMSLELGGKSPVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYI 325 Query: 253 DPSIQNQIVEKLKKSLKEFYGED-AKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTG-- 309 + + ++E++ K + G ++SA+ +RV G I+ Sbjct: 326 HSKVFDGVIERVAKIAASLKIGPGMDPATQIGPLVSAKQRERVCGYIDSGFGEGARAAAG 385 Query: 310 ----DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALY 365 D ++ PT+L D V++EEIFGPVL + ++ A+Q N L Sbjct: 386 GRAIDGPGFFVEPTVLVDTTQAMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYGLGAS 445 Query: 366 MFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHR 425 ++S++ I K++ ++G V N + ++LPFGG+ SG G G+ + ++ Sbjct: 446 IWSNDLSAIHKLVPRIAAGTVWVN--CHSLLDNALPFGGMKQSGFGRELGRAVIDQYTES 503 Query: 426 RSCLVR 431 +S ++ Sbjct: 504 KSVMMN 509 >3JZ4-A nrPDB Length = 481 Score = 475 bits (1222), Expect = e-134, Method: Composition-based stats. Identities = 111/439 (25%), Positives = 188/439 (42%), Gaps = 16/439 (3%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + A+ A A + R + R L L+ E + +L + + K A Sbjct: 47 DETRAAIDAANRALPAWRALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEA-K 105 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 E+ Y IE+ ++ D + L + +P+GV I WN+P + Sbjct: 106 GEISYAASFIEWFAEEGKRIYGDTIPGHQADKR---LIVIKQPIGVTAAITPWNFPAAMI 162 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELLKER 180 + A+AAG ++VLKP+ + A LA + I + ++ V+ G L Sbjct: 163 TRKAGPALAAGCTMVLKPASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSN 222 Query: 181 --FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 + +TGST +G+ +M AK + V+LELGG +P V + DLD A KF Sbjct: 223 PLVRKLSFTGSTEIGRQLMEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFR 282 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGL 297 N+GQTCV + + + ++ EKL++++ + G+ G +I + +V Sbjct: 283 NAGQTCVCANRLYVQDGVYDRFAEKLQQAMSKLHIGDGLDNGVTIGPLIDEKAVAKVEEH 342 Query: 298 I-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 I +G +V GG + + PTIL DV + V +EE FGP+ P+ + + Sbjct: 343 IADALEKGARVVCGGKAHERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADV 402 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411 I N E LA Y ++ + + ++ G V N I+ + PFGG+ SG+G Sbjct: 403 IAQANDTEFGLAAYFYARDLSRVFRVGEALEYGIVGINTGIISNEV--APFGGIKASGLG 460 Query: 412 SYHGKKSFETFSHRRSCLV 430 K E + + + Sbjct: 461 REGSKYGIEDYLEIKYMCI 479 >3R31-A nrPDB Length = 517 Score = 468 bits (1205), Expect = e-132, Method: Composition-based stats. Identities = 113/447 (25%), Positives = 184/447 (41%), Gaps = 18/447 (4%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 + A+ A+ A R + L+ +++E+ L D K + Sbjct: 54 VERAIASAKRAQKEWAAMSPMARGRILKRAADIMRERNDALSTLETLDTGKPIQETIVAD 113 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 + E+ P + + D Y PLGV + IG WNYP + Sbjct: 114 PTSGADAFEFFGGIAPSALNGDYI----PLGGDFAYTKRVPLGVCVGIGAWNYPQQIACW 169 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELLKE-RF 181 A+ AGN++V KPSE + A +A I I L K L+ VI G L+ Sbjct: 170 KAAPALVAGNAMVFKPSENTPLGALKIAEILIEAGLPKGLFNVIQGDRDTGPLLVNHPDV 229 Query: 182 DHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSG 241 + TGS G+ + AAA HL VT+ELGGKSP V + D++ A G F +SG Sbjct: 230 AKVSLTGSVPTGRKVAAAAAGHLKHVTMELGGKSPMIVFDDADIESAVGGAMLGNFYSSG 289 Query: 242 QTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQRVMGLIE- 299 Q C + + + +E LK+ + G+ + G ++S ++V+ IE Sbjct: 290 QVCSNGTRVFVQKKAKARFLENLKRRTEAMILGDPLDYATHLGPLVSKAQQEKVLSYIEK 349 Query: 300 ----GQKVAYGGTGD----AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 G + GG Y+ PT+ DV + +EEIFGPV+ ++ +E Sbjct: 350 GKAEGATLITGGGIPNNVAGEGAYVQPTVFADVTDDMTIAREEIFGPVMCVLDFDDEDEV 409 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411 + N E LA +F+++ +++ +G + N ++ +PFGG SG G Sbjct: 410 LARANATEFGLAGGVFTADLARAHRVVDGLEAGTLWIN--TYNLCPVEIPFGGSKQSGFG 467 Query: 412 SYHGKKSFETFSHRRSCLVRPLMNDEG 438 + + E +S ++ V D Sbjct: 468 RENSAAALEHYSELKTVYVSTGKVDAP 494 >6C43-A nrPDB Length = 477 Score = 462 bits (1188), Expect = e-130, Method: Composition-based stats. Identities = 104/428 (24%), Positives = 178/428 (41%), Gaps = 15/428 (3%) Query: 14 AFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEY 73 AF+ + R + L L I++ E + + K +E+ +++ + Sbjct: 54 AFAEWGQTTPKARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRF 113 Query: 74 MIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGN 133 + E + I +P+GVV I WNYP + + A+AAGN Sbjct: 114 FAGAARCLSGLAAGE---YLEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGN 170 Query: 134 SVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL--KERFDHILYTGSTG 191 VV+KPSE++ A LA + + V+ G ++L E+ + TGS Sbjct: 171 CVVIKPSEITPLTALKLAVLAKDIFPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIA 230 Query: 192 VGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYIL 251 G+ I+ A + +ELGGK+P V + DLD + + F N+GQ C A I Sbjct: 231 TGEHILRHTAPAIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIY 290 Query: 252 CDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIEGQK-------V 303 I + +VEKL ++ G +S + G + S H +RV +E K + Sbjct: 291 AQRGIYDALVEKLGNAVSSLKMGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVI 350 Query: 304 AYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLA 363 G + Y APT+L D + ++Q E+FGPV+ I ++ +++ N LA Sbjct: 351 TGGSQTEGKGYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLA 410 Query: 364 LYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFS 423 +++ + ++ A G N + + +P GG SG G E ++ Sbjct: 411 SSVWTQDVGRAHRLSARLQYGCTWINTHF--MLVSEMPHGGQKQSGYGKDMSLYGLEDYT 468 Query: 424 HRRSCLVR 431 R +V+ Sbjct: 469 LVRHIMVK 476 >6B4R-B nrPDB Length = 497 Score = 461 bits (1186), Expect = e-130, Method: Composition-based stats. Identities = 115/447 (25%), Positives = 196/447 (43%), Gaps = 22/447 (4%) Query: 1 MSKISEAVKRARAAFS--SGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 ++ +AVK AR AF + R Q + L+ E +EL D+ K + Sbjct: 56 LADAEQAVKVARNAFDSGAWSRLAPAKRKQTMIRFADLLLENAEELALLETLDMGKPISD 115 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118 + + +V + + + + + E + + EP+GVV I WN+P Sbjct: 116 SLHIDVASAANSLRWSAEAIDKIYD----EVAATPHAELGLVTREPVGVVAAIVPWNFPL 171 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177 ++ + A+A GNSV+LKPSE S A +A + + + K ++ V+ G + L Sbjct: 172 LMSCWKLGPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKGVFNVLPGYGHTVGKAL 231 Query: 178 KER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNC-DLDVACRRIA 233 D +++TGST + K +M A + ++ V LE GGKSP V + DL A A Sbjct: 232 ALHMDVDTLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNIVFADAPDLKAAAEAAA 291 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQ 292 N G+ C A +L + SI+++ + + ++LK + G + G ++ + Sbjct: 292 GAIAFNQGEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPLDPETNVGALVDTQQMN 351 Query: 293 RVMGLIE-----GQKVAYGGTG---DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVC 344 V+ IE G K+ GG + Y+ PTI V + +EEIFGPVL ++ Sbjct: 352 TVLSYIEAGHNDGAKLVAGGKRTLEETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVIE 411 Query: 345 VRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGG 404 EEA++ N LA +++SN +G V N + PFGG Sbjct: 412 FEDAEEAVRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWVNQ--YDGGDMTAPFGG 469 Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLVR 431 SG G +F+ ++ ++ ++ Sbjct: 470 FKQSGNGRDKSLHAFDKYTELKATWIK 496 >5KLK-A nrPDB Length = 520 Score = 460 bits (1185), Expect = e-130, Method: Composition-based stats. Identities = 118/446 (26%), Positives = 192/446 (43%), Gaps = 19/446 (4%) Query: 3 KISEAVKRARAAFSS-GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 +++EAV A+ A +Q R + + IQ + +E V A AD + A Sbjct: 76 QVNEAVVAAQNALKGPWGKLSVQDRAALIHKIADGIQARFEEFVAAEVADTGRPVHQART 135 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 ++ + D T Y +PLGV+ VI W+ P L Sbjct: 136 LDIPRAIANFRTFADLAKTSHTDLFEMSTSDGSGALNYTVRKPLGVIGVISPWDLPLLLF 195 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPE-TTELLKE 179 + A+A GN+VV KPSE S + A+LLA ++ + ++ +I+G + E L + Sbjct: 196 TWKVAPALACGNTVVAKPSEESPSSATLLAEVMHDAGVPPGVFNLIHGFGKDSAGEFLTQ 255 Query: 180 R--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKF 237 + +TG + G IM A A + V+ ELGGK+ V + DLD A + F Sbjct: 256 HPGISALTFTGESKTGSTIMKAVADGVKEVSFELGGKNAAVVFADADLDAAIEGVLRSSF 315 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKL-KKSLKEFYGEDAKKSRDYGRIISARHFQRVMG 296 NSGQ C+ + + SI ++ V L ++ + G + + G +IS H +V+ Sbjct: 316 TNSGQVCLCSERVYVHRSIFDEFVSGLKVEAERLVVGYPDQDGVNMGPLISHGHRDKVLS 375 Query: 297 L-----IEGQKVAYGGTGD------AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 EG V GG Y+ PTI T + ++ + EEIFGPV I Sbjct: 376 YYRLAVDEGATVVTGGGVPKFNDERDQGAYVQPTIWTGLSDKARCVTEEIFGPVCHISPF 435 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 +E I +N LA ++++N ++ + G V N ++ PFGGV Sbjct: 436 DDEDEVINRVNDSNYGLACAIWTTNLSRAHRVSRQIHVGLVWVN--TWYLRDLRTPFGGV 493 Query: 406 GNSGMGSYHGKKSFETFSHRRSCLVR 431 SG+G G+ S + +S + ++ Sbjct: 494 KLSGLGREGGRFSMDFYSDIANICIK 519 >2D4E-A nrPDB Length = 515 Score = 460 bits (1183), Expect = e-130, Method: Composition-based stats. Identities = 119/446 (26%), Positives = 189/446 (42%), Gaps = 25/446 (5%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 ++ A K A AF + R + L + LI++ EL D + Sbjct: 65 EVDRAAKAAHEAFQRWSRTKAKERKRYLLRIAELIEKHADELAVMECLDAGQVLRIVR-A 123 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 +V E + + D P + Y P G V +I WN P L+ Sbjct: 124 QVARAAENFAFYAEYAEHAMED---RTFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLST 180 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER- 180 + A+A GN+VVLKP+E S A+ LA I+ + L ++ ++ G E L Sbjct: 181 WRIAPALAFGNTVVLKPAEWSPFTATKLAEILKEADLPPGVFNLVQGFGEEAGAALVAHP 240 Query: 181 -FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 + TG T GKI+M AA HL ++ ELGGKSP V + DL+ A + + F Sbjct: 241 LVPLLTLTGETETGKIVMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFSF 300 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298 +G+ C A +L + I V K+ + + G + G +I H QRV+G + Sbjct: 301 NGERCTASSRLLVEEKIFEDFVGKVVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYV 360 Query: 299 -----EGQKVAYGGTG---------DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVC 344 EG ++ GG + Y+ PT+ + + QEEIFGPVL + Sbjct: 361 EAGKREGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVAIP 419 Query: 345 VRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGG 404 + EEA++ N + LA Y+F+ + + ++ E +G V N V PFGG Sbjct: 420 FKDEEEALRKANDTKYGLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLP--TPFGG 477 Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLV 430 V SG G + + ++ ++ + Sbjct: 478 VKGSGDRREGGTYALDFYTDLKTIAL 503 >4I8Q-A nrPDB Length = 514 Score = 458 bits (1178), Expect = e-129, Method: Composition-based stats. Identities = 129/459 (28%), Positives = 204/459 (44%), Gaps = 20/459 (4%) Query: 2 SKISEAVKRARAA--FSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNA 59 + AV+ AR A + R + L A+ + E++ L + D K + + Sbjct: 61 EDVDIAVEAARKAIARDDWGSTTGAQRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYES 120 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 ++ V EY + + + Y+ EPLGVV +I WNYP Sbjct: 121 A-ADMDDVAGCFEYYAGLAEALDSRRMTPVNLNSDSYKSYVLREPLGVVGLITPWNYPLL 179 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELL- 177 + I + A+AAG + +LKPSEL+ L I + L ++ G PE L Sbjct: 180 MAIWKVAPALAAGCAAILKPSELASITCLELGEICREIGLPSGALNILTGLGPEAGGPLA 239 Query: 178 -KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCD-LDVACRRIAWG 235 D I +TGS G IMTAAA+ + PV+L LGGKSP V + D LD+A +G Sbjct: 240 SHPHVDKISFTGSGPTGSKIMTAAAQLVKPVSLALGGKSPIVVFDDIDNLDIAAEWTLFG 299 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYG-EDAKKSRDYGRIISARHFQRV 294 F N+GQ C A ++ +I + +++L K K + ++ G ++SA +++V Sbjct: 300 IFANTGQVCSATSRLIVQENIASAFMDRLLKWTKNIKISDPLEEDCKLGPVVSAGQYEKV 359 Query: 295 MGLI-----EGQKVAYGGTGD---AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346 + I EG + GG Y+ PTI+TDV+ + +EE+FGPVL + + Sbjct: 360 LKFISNAKSEGATILCGGERPQHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFK 419 Query: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406 + E+AI+ N + L + S + K ++ +G + N T + LP+GG Sbjct: 420 TEEQAIELANDTKYGLGAAVMSKDVKRCERFTKAFQTGIIWIN--CSQPTFNELPWGGKK 477 Query: 407 NSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPP 445 SG G GK E F + + + E L P Sbjct: 478 RSGFGRDLGKWGLENFLNIKQVT--EYTSAEPLAFYKSP 514 >5IUV-A nrPDB Length = 497 Score = 454 bits (1168), Expect = e-128, Method: Composition-based stats. Identities = 111/446 (24%), Positives = 192/446 (43%), Gaps = 22/446 (4%) Query: 2 SKISEAVKRARAAFS--SGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNA 59 + AV+ AR+AF + R + L+++ +EL D+ K ++ Sbjct: 57 ADAQRAVESARSAFDSGAWSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDS 116 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 ++ + + + + + E + EP+GVV I WN+P Sbjct: 117 LGVDIPGGARALSWSGEAIDKLYD----EVAATPHDQLGLVTREPVGVVAAIVPWNFPLM 172 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELLK 178 + + A++ GNSVVLKPSE S A +A + I + + V+ G + L Sbjct: 173 MACWKLGPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALA 232 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNC-DLDVACRRIAW 234 D +++TGST + K +M A + ++ V LE GGKSP V + DL A A Sbjct: 233 LHMDVDTVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAAS 292 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQR 293 N G+ C A +L + SI+++ + + ++L + G + + G ++ + Sbjct: 293 AIAFNQGEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNT 352 Query: 294 VMGLI-----EGQKVAYGGTG---DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 V+ I +G ++ GG + Y+ PTI V+ + QEEIFGPVL ++ Sbjct: 353 VLSYIAAGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTF 412 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 + EEAIQ N LA ++++N +G V N + PFGG Sbjct: 413 DTAEEAIQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWVNQ--YDGGDMTAPFGGF 470 Query: 406 GNSGMGSYHGKKSFETFSHRRSCLVR 431 SG G +F+ ++ +S ++ Sbjct: 471 KQSGNGRDKSLHAFDKYTELKSTWIK 496 >4QYJ-A nrPDB Length = 516 Score = 452 bits (1164), Expect = e-127, Method: Composition-based stats. Identities = 116/446 (26%), Positives = 196/446 (43%), Gaps = 18/446 (4%) Query: 1 MSKISEAVKRARAAF--SSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 58 + ++ AV+ A A + R P R + L L L++ EL + K Sbjct: 71 VEDVNAAVESAAATLRSDTWRRMPPSARERILLRLADLLEVHGDELARLETLNNGKLLIY 130 Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAAD--EPVEKTPQTQQDELYIHSEPLGVVLVIGTWNY 116 + EV + + YM + + P + P+GVV I WN+ Sbjct: 131 SKLMEVGASAQWLRYMAGWATKLTGSTLDLSLPLPPEVRSRASTQRVPVGVVAAIIPWNF 190 Query: 117 PFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTE 175 P + + + A+A GN+VVLKP+E + A LA + + L V+ G + Sbjct: 191 PLLMAVWKIAPALACGNTVVLKPAEETPLTALRLAELAMEAGLPAGALNVVTGRGETAGD 250 Query: 176 LLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 L + +TGST VG+II +A + L V+LELGGKSP V +CD A A Sbjct: 251 ALVRHPKVAKVAFTGSTEVGRIIGSACGRSLKAVSLELGGKSPVIVLADCDPQEAAEGAA 310 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQ 292 F N GQ C A + SI ++++L + G ++ G ++S +H + Sbjct: 311 AAIFFNHGQVCTAGSRLYVHESIYEDVIQRLAVIGESIVVGSGLEQGVHMGPMVSKKHHE 370 Query: 293 RVM-----GLIEGQKVAYGGTGD--AATRYIAPTILTDVD-PQSPVMQEEIFGPVLPIVC 344 V+ G+ +G + GGT A ++ PTI + + ++ +E+FGPVL Sbjct: 371 NVLRHIRNGIEDGADLICGGTEAPCAQGFFVKPTIFANREKKDIRLLSQEVFGPVLVATP 430 Query: 345 VRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGG 404 + E + N+ L +++++ ++ E +G V N ++ +LPFGG Sbjct: 431 FSDIAEVVNEANRSVYGLGASIWTNDLSAALRINDELEAGTVWVN--THNMVDPNLPFGG 488 Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLV 430 +SG+G HG + E ++ RS ++ Sbjct: 489 FKDSGVGREHGAAAIEHYTTTRSLVI 514 >4F3X-A nrPDB Length = 498 Score = 451 bits (1162), Expect = e-127, Method: Composition-based stats. Identities = 106/441 (24%), Positives = 178/441 (40%), Gaps = 17/441 (3%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 ++I AV A AF R L + I+++ E A + K Sbjct: 62 AQIDAAVDAAERAFVGWSQTTPAERSNALLKIADAIEKEADEFAALEALNCGKPINAVKN 121 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 +E+ +++ + + A E P I +P+G+V I WNYP + Sbjct: 122 DELPAIIDCWRFFAGAVRNLHAPAAGEYLPGHTSM---IRRDPIGIVGSIAPWNYPLMMM 178 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER- 180 + AI GN+VV KPSE + A LA +I L + + VI G L Sbjct: 179 AWKLAPAIGGGNTVVFKPSEQTPLTALKLARLIADILPEGVVNVITGRGETVGNALINHP 238 Query: 181 -FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 + TG GK ++ AAAK + LELGGK+P V + DL+ I + N Sbjct: 239 KVGMVSITGDIATGKKVLAAAAKTVKRTHLELGGKAPVIVYGDADLEAVVNGIRTFGYYN 298 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGE-DAKKSRDYGRIISARHFQRVMGLI 298 +GQ C A I + I ++V L ++ D + G +IS R RV + Sbjct: 299 AGQDCTAACRIYAEAGIYEKLVADLTSAVSTIRYNLDDDTENEIGPLISRRQRDRVASFV 358 Query: 299 EGQ------KVAYGGT-GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 E ++ GG G + PT++ + +++ E+FGPV+ + ++A Sbjct: 359 ERAADQKHIEITTGGRTGSDEGFFFQPTVVAGATQEDEIVRREVFGPVVSVTRFTGKDDA 418 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITL-HSLPFGGVGNSGM 410 + + N + LA +++ + + + G N H L + +P GG+ SG Sbjct: 419 VAWANDSDYGLASSVWTKDISKAMRAASRLQYGCTWIN---THFMLTNEMPHGGIKQSGY 475 Query: 411 GSYHGKKSFETFSHRRSCLVR 431 G + E ++ R ++ Sbjct: 476 GKDMSVYALEDYTAVRHIMIN 496 >1WNB-A nrPDB Length = 495 Score = 451 bits (1161), Expect = e-127, Method: Composition-based stats. Identities = 104/428 (24%), Positives = 178/428 (41%), Gaps = 21/428 (4%) Query: 17 SGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQ 76 + R + L L +I+E Q + + K +A+ +E+ +++ + Sbjct: 75 EWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAG 134 Query: 77 K---LPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGN 133 L AA E +E I +PLGVV I WNYP + + A+AAGN Sbjct: 135 AARCLNGLAAGEYLEGHTSM------IRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGN 188 Query: 134 SVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER--FDHILYTGSTG 191 VVLKPSE++ A LA + + ++ G + L + TGS Sbjct: 189 CVVLKPSEITPLTALKLAELAKDIFPAGVVNILFGRGKTVGDPLTGHPKVRMVSLTGSIA 248 Query: 192 VGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYIL 251 G+ I++ A + +ELGGK+P V + D++ + + N+GQ C A I Sbjct: 249 TGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIY 308 Query: 252 CDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQRVMGLIEGQK-------V 303 I + +VEKL ++ G +S + G + S H +RV +E K + Sbjct: 309 AQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVI 368 Query: 304 AYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLA 363 G Y APT+L ++Q+E+FGPV+ + + E+ + + N + LA Sbjct: 369 TGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLA 428 Query: 364 LYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFS 423 +++ + ++ A G N + + +P GG SG G E ++ Sbjct: 429 SSVWTKDVGRAHRVSARLQYGCTWVNTHF--MLVSEMPHGGQKLSGYGKDMSLYGLEDYT 486 Query: 424 HRRSCLVR 431 R +V+ Sbjct: 487 VVRHVMVK 494 >3I44-A nrPDB Length = 497 Score = 451 bits (1160), Expect = e-127, Method: Composition-based stats. Identities = 119/439 (27%), Positives = 202/439 (46%), Gaps = 21/439 (4%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 +A+ A+ AF + +T R+ +E + + +++ ++ ++ ++ A Sbjct: 64 DADKAINAAKKAFQTWKTTSPHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNA 123 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 + I I+ E++ E + + ++ +H + +GVV +I WN+P N Sbjct: 124 QTATGSSHIRNFIKAYKEFSFQEALIE----GNEQAILHYDAIGVVGLITPWNWPMNQVT 179 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERF 181 ++ A+ AG ++VLKPSE++ A L A I+ + L ++ +ING L Sbjct: 180 LKVIPALLAGCTMVLKPSEIAPLSAMLFAEILDEAALPSGVFNLINGDGANVGSYLSAHP 239 Query: 182 D--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 D I +TGST GK I A+ L V LELGGK + + D+D A +R F N Sbjct: 240 DLEMISFTGSTRAGKDISKNASNTLKRVCLELGGKGANIIFADADID-ALQRGVRHCFYN 298 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKK-SLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298 SGQ+C AP +L + +I ++ ++ K + K G + G ++S + ++ LI Sbjct: 299 SGQSCNAPTRMLVEQAIYDKAIKTAKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLI 358 Query: 299 -----EGQKVAYGGTGD----AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 EG + GGTG Y+ PT+ DV P + +EEIFGPVL ++ + + Sbjct: 359 QSGIDEGATLVTGGTGLPMGMERGYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTED 418 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 EA+ N E L Y+ S + +++ A+ SG V N H FGGV SG Sbjct: 419 EAVTLANDTEYGLTNYIQSQDRSKCRRIAAQVRSGMVEVNG---HELPGGSYFGGVKFSG 475 Query: 410 MGSYHGKKSFETFSHRRSC 428 G + F ++ Sbjct: 476 RAREGGLWGIKEFLDTKAI 494 >3TY7-A nrPDB Length = 478 Score = 438 bits (1128), Expect = e-123, Method: Composition-based stats. Identities = 124/440 (28%), Positives = 197/440 (44%), Gaps = 24/440 (5%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + + +AV+ A + R ++ R L+ + + + ++ ++V A+ +L + Sbjct: 45 ADVDKAVEAADDVYLEFRHTSVKERQALLDKIVKEYENRKDDIVQAITDELGAPLSLSER 104 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 L L + +E ++ + + E +GV +I WN+P N T Sbjct: 105 VHYQMGLNHFVAARDALDNYEFEE--------RRGDDLVVKEAIGVSGLITPWNFPTNQT 156 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELLKER 180 + A AAG+ VVLKPSE + A +LA I + + K ++ ++NG L E Sbjct: 157 SLKLAAAFAAGSPVVLKPSEETPFAAVILAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEH 216 Query: 181 --FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 + +TGS G IM AAK V+LELGGKSP V + D+ A + Sbjct: 217 PKVRMMSFTGSGPTGSKIMEKAAKDFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVN 276 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGL 297 N+GQ C A +L I++ + +LK+ + G + G IIS + F +V Sbjct: 277 NTGQVCTAGTRVLVPNKIKDAFLAELKEQFSQVRVGNPREDGTQVGPIISKKQFDQVQNY 336 Query: 298 I-----EGQKVAYGG----TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 I EG ++ YGG G + PTI +VD Q + QEEIFGPV+ ++ L Sbjct: 337 INKGIEEGAELFYGGPGKPEGLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDL 396 Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408 +EAIQ N + LA Y+ + + + K+ +G V N+ LPFGG S Sbjct: 397 DEAIQIANDTKYGLAGYVIGKDKETLHKVARSIEAGTVEINEA---GRKPDLPFGGYKQS 453 Query: 409 GMGSYHGKKSFETFSHRRSC 428 G+G G E F +S Sbjct: 454 GLGREWGDYGIEEFLEVKSI 473 >4V6H-A nrPDB Length = 484 Score = 438 bits (1128), Expect = e-123, Method: Composition-based stats. Identities = 107/423 (25%), Positives = 180/423 (42%), Gaps = 16/423 (3%) Query: 18 GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQK 77 R + + R L L+ +L L + K A E+ Y IE+ ++ Sbjct: 66 WRMKTAKERAAILRRWFDLVIANSDDLALILTTEQGKPLAEA-KGEIAYAASFIEWFAEE 124 Query: 78 LPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVL 137 A D + + EP+GV I WN+P + + + A+AAG +V+ Sbjct: 125 GKRVAGDT---LPTPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGCPIVV 181 Query: 138 KPSELSENMASLLATIIP-QYLDKDLYPVINGGVPETTELLKER--FDHILYTGSTGVGK 194 KP+E + A +A + + K + V+ G + + +TGST VG+ Sbjct: 182 KPAESTPFSALAMAFLAERAGVPKGVLSVVIGDPKAIGTEITSNPIVRKLSFTGSTAVGR 241 Query: 195 IIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDP 254 ++M +A + +TLELGG +P V + DLD A K+ N+GQTCV + Sbjct: 242 LLMAQSAPTVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNRFFVHE 301 Query: 255 SIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGT 308 + + +KL ++ + G + G +I+ ++V I +G + GG Sbjct: 302 RVYDAFADKLAAAVSKLKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASLMTGGK 361 Query: 309 GDAATR-YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367 A + PT+LT V P V +EE FGP+ P+ S EE ++ N E LA Y++ Sbjct: 362 RHALGHGFFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGLAAYLY 421 Query: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427 S + + ++ G V N ++ + PFGGV SG+G + + + Sbjct: 422 SRDIGRVWRVAEALEYGMVGINTGLISNEV--APFGGVKQSGLGREGSHYGIDDYVVIKY 479 Query: 428 CLV 430 V Sbjct: 480 LCV 482 >3QAN-A nrPDB Length = 538 Score = 437 bits (1124), Expect = e-123, Method: Composition-based stats. Identities = 114/440 (25%), Positives = 191/440 (43%), Gaps = 20/440 (4%) Query: 5 SEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEV 64 +A++ A AF + R + R L +I+ ++ E L + K W + Sbjct: 77 EKAIQSADEAFQTWRNVNPEERANILVKAAAIIRRRKHEFSAWLVHEAGKP-WKEADADT 135 Query: 65 VYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQP 124 ++ +EY +++ E + + P Q Y P+GV + I WN+ + + Sbjct: 136 AEAIDFLEYYARQMIELNRGKEILSRPGEQNRYFYT---PMGVTVTISPWNFALAIMVGT 192 Query: 125 MVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFD- 182 V I GN+VVLKP+ + +A+ ++ L K + + G E + L + Sbjct: 193 AVAPIVTGNTVVLKPASTTPVVAAKFVEVLEDAGLPKGVINYVPGSGAEVGDYLVDHPKT 252 Query: 183 -HILYTGSTGVGKIIMTAAA------KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 235 I +TGS VG + AA HL V +E+GGK VD++ DLD+A I Sbjct: 253 SLITFTGSKDVGVRLYERAAVVRPGQNHLKRVIVEMGGKDTVVVDRDADLDLAAESILVS 312 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRV 294 F SGQ C A + + ++++EK K G+ + G +I + F+++ Sbjct: 313 AFGFSGQKCSAGSRAVIHKDVYDEVLEKTVALAKNLTVGDPTNRDNYMGPVIDEKAFEKI 372 Query: 295 MGLIE----GQKVAYGGTGDAA-TRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 M IE ++ GG GD++ +I PTI+ D+DP++ +MQEEIFGPV+ + Sbjct: 373 MSYIEIGKKEGRLMTGGEGDSSTGFFIQPTIIADLDPEAVIMQEEIFGPVVAFSKANDFD 432 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 A++ N E L + + N I++ E G + N + PFGG SG Sbjct: 433 HALEIANNTEYGLTGAVITRNRAHIEQAKREFHVGNLYFNRNCTGAIVGYHPFGGFKMSG 492 Query: 410 MGSY-HGKKSFETFSHRRSC 428 S G ++ Sbjct: 493 TDSKAGGPDYLALHMQAKTV 512 >5EUY-A nrPDB Length = 491 Score = 436 bits (1121), Expect = e-122, Method: Composition-based stats. Identities = 112/459 (24%), Positives = 206/459 (44%), Gaps = 24/459 (5%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 EA+ A A + P R + L + + ++ +++ + L + + + Sbjct: 46 EDAREAIDSAFEALKAWANIPAIRRAEYLYKMLEVFRQMKEDFMKILTVE-GGGTYRKVW 104 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 EVV+ I+ + + ++ + GVV VI WNYP +++ Sbjct: 105 GEVVFTERLIQNAAELARHYQGRV---LQSDSESTISVVFKRSKGVVGVITPWNYPLSIS 161 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL--K 178 ++ + +A GN+VV KP+ + L+A ++ + L K ++ ++ G P E + Sbjct: 162 MKKIAHTLAVGNTVVYKPASDTPVTGWLIAQMVAKAGLPKGVFNLVIGPGPVVGEEIVTH 221 Query: 179 ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 +R H+ +TG + G+ I AA L VTLELGG P + + D+D A R + Sbjct: 222 KRVAHVTFTGESSTGREIAAKAAGTLKTVTLELGGSDPLIILDDVDVDYAARLAVFASLF 281 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDA--KKSRDYGRIISARHFQRVMG 296 + GQ C + I+ ++ ++ +E+ +K +D + D G +I+ R + Sbjct: 282 HQGQICTSAKRIIVHKAVADKFIERYVHYVKMLRIDDPRKDEKVDLGPLINERQVALMKE 341 Query: 297 LIE-----GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 ++ G ++ GG + + P I DVD +M+EE+FGPV PIV V + ++A Sbjct: 342 FVDDAVSRGGRLLIGGR--SWGNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQA 399 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411 ++ N + L+ + ++N ++ SG NDV H +PFGG+ SG+G Sbjct: 400 VEVANDTDYGLSGAVLTNNVNRAFRIAEAVESGMFHINDVTFLEESH-VPFGGIKASGVG 458 Query: 412 SYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKM 450 G+ SF ++ R V L+ R P P+ + Sbjct: 459 REGGEWSFHETTYDRWVTVT-------LRTRRFPIPSAL 490 >3RHD-A nrPDB Length = 486 Score = 434 bits (1116), Expect = e-122, Method: Composition-based stats. Identities = 128/447 (28%), Positives = 205/447 (45%), Gaps = 26/447 (5%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + EA+ A + P+ R L + + I+E+++EL LA D K A Sbjct: 34 EEAKEAIDTAEKYKEVMKNLPITKRYNILMNIAKQIKEKKEELAKILAIDAGKPIKQARV 93 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 EV + KL + E ++ + ++ EP+G+V I +N+P NL+ Sbjct: 94 -EVERSIGTF-----KLAAFYVKEHRDEVIPSDDRLIFTRREPVGIVGAITPFNFPLNLS 147 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYL-----DKDLYPVINGGVPETTE- 175 + AIA GN +V PS + + LA II L +Y ++ G + Sbjct: 148 AHKIAPAIATGNVIVHHPSSKAPLVCIELAKIIENALKKYNVPLGVYNLLTGAGEVVGDE 207 Query: 176 -LLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 ++ E+ + I +TGS+ VG++I A + LELGG +P V K+ DL+ A + Sbjct: 208 IVVNEKVNMISFTGSSKVGELITKKAG--FKKIALELGGVNPNIVLKDADLNKAVNALIK 265 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293 G F+ +GQ C++ IL D SI ++ +E K G + D G +IS H + Sbjct: 266 GSFIYAGQVCISVGMILVDESIADKFIEMFVNKAKVLNVGNPLDEKTDVGPLISVEHAEW 325 Query: 294 VMGLI-----EGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 V ++ EG K+ GG D A Y PTIL +VD + + + E F PV+PI+ + Sbjct: 326 VEKVVEKAIDEGGKLLLGGKRDKALFY--PTIL-EVDRDNILCKTETFAPVIPIIR-TNE 381 Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408 EE I N E L +F+++ K GGV ND + ++PFGGV S Sbjct: 382 EEMIDIANSTEYGLHSAIFTNDINKSLKFAENLEFGGVVINDSSL-FRQDNMPFGGVKKS 440 Query: 409 GMGSYHGKKSFETFSHRRSCLVRPLMN 435 G+G K + E S+ ++ ++ N Sbjct: 441 GLGREGVKYAMEEMSNIKTIIISKAEN 467 >4LIH-A nrPDB Length = 504 Score = 432 bits (1112), Expect = e-121, Method: Composition-based stats. Identities = 125/427 (29%), Positives = 189/427 (44%), Gaps = 18/427 (4%) Query: 17 SGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQ 76 + R L L++E EL D K + +V +E+ + Sbjct: 82 VWAGLNPRARKAVLLRWAALMREHLDELSLLETLDAGKPIGDTTTVDVPGAAYCVEWFAE 141 Query: 77 KLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVV 136 + E P + EP+GVV + WN+P + A+AAGNSVV Sbjct: 142 AID----KVGGEVAPADHHLVGLVTREPVGVVAAVVPWNFPILMAAWKFGPALAAGNSVV 197 Query: 137 LKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELLKER-FDHILYTGSTGVGK 194 LKPSE S A +A + + ++ V+ G L R D I +TGST VGK Sbjct: 198 LKPSEKSPLTAIRVAQLAFEAGIPAGVFNVVPGAGEPGKLLALHRDVDCIAFTGSTAVGK 257 Query: 195 IIMTAAAK-HLTPVTLELGGKSPCYVDKNC-DLDVACRRIAWGKFMNSGQTCVAPDYILC 252 +IM AA+ +L LELGGKSP V +C DLD A + A F N G+ C A +L Sbjct: 258 LIMQYAAQSNLKRAWLELGGKSPNIVLPDCPDLDRAAQTAAGAIFYNMGEMCTAGSRLLV 317 Query: 253 DPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQRVMGLIEG----QKVAYGG 307 I++ +EKL + + + G S G I+ +RV+G IE ++ GG Sbjct: 318 HRDIKDAFIEKLVAAARAYVPGNPLDPSVSMGAIVDGIQLERVLGYIEAGRGEGRLVTGG 377 Query: 308 TG---DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLAL 364 + Y+ PT+ +V P + + +EEIFGPVL ++ ++EA++ N E LA Sbjct: 378 ARVNAETGGFYVEPTVF-EVKPDAKIAREEIFGPVLSVIVFDDVDEAVRIANDTEYGLAA 436 Query: 365 YMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSH 424 +++SN + +G V N + PFGG SG G + E ++ Sbjct: 437 AVWTSNLTTAHDVSRRLRAGTVWVNCYDEGG-DMNFPFGGYKQSGNGRDKSLHALEKYTE 495 Query: 425 RRSCLVR 431 +S L+R Sbjct: 496 LKSTLIR 502 >3RJL-A nrPDB Length = 538 Score = 431 bits (1109), Expect = e-121, Method: Composition-based stats. Identities = 118/440 (26%), Positives = 196/440 (44%), Gaps = 20/440 (4%) Query: 5 SEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEV 64 +A++ A AF + R + R L ++ ++ E L + K WN + Sbjct: 77 EKAIQAAAKAFETWRYTDPEERAAVLFRAVAKVRRKKHEFSALLVKEAGKP-WNEADADT 135 Query: 65 VYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQP 124 ++ +EY +++ E A +PV + +Y P GV +VI WN+ F + Sbjct: 136 AEAIDFMEYYARQMIELAKGKPVNSREGERNQYVYT---PTGVTVVIPPWNFLFAIMAGT 192 Query: 125 MVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELLKERFDH 183 V I GN+VVLKP+ + +A+ ++ + L K + + G E + L + Sbjct: 193 TVAPIVTGNTVVLKPASAAPVIAAKFVEVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKT 252 Query: 184 --ILYTGSTGVGKIIMTAAAK------HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 235 I +TGS VG I AAK HL V E+GGK VD++CD+++A + I Sbjct: 253 SIITFTGSREVGTRIFERAAKVQPGQTHLKQVIAEMGGKDTVVVDEDCDIELAAQSIFTS 312 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKEFYGEDAKKSRDYGRIISARHFQRV 294 F +GQ C A + + +++++++ + + + GE G +I F ++ Sbjct: 313 AFGFAGQKCSAGSRAVVHEKVYDEVLKRVIEITESKKVGEPDSADVYMGPVIDQASFNKI 372 Query: 295 MGLIE-----GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 M IE G+ V+ G D+ +I PTI D+DP++ +MQEEIFGPV+ V S + Sbjct: 373 MDYIEIGKEEGRLVSGGKGDDSKGYFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSSFD 432 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 EA++ N E L + + N I + E G + N + PFGG SG Sbjct: 433 EALEVANNTEYGLTGAVITKNRDHINRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSG 492 Query: 410 MGSY-HGKKSFETFSHRRSC 428 S G ++ Sbjct: 493 TDSKAGGPDYLALHMQAKTI 512 >5UR2-A nrPDB Length = 984 Score = 428 bits (1100), Expect = e-120, Method: Composition-based stats. Identities = 104/431 (24%), Positives = 184/431 (42%), Gaps = 19/431 (4%) Query: 14 AFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEY 73 A+ + + P + R ++ L ++ +L+ ++ K W ++ ++ Y Sbjct: 545 AYKTWKNVPCEQRAALVDKLADIMTRDRFKLIATQVLEVGKP-WAEADGDIGEAIDFCRY 603 Query: 74 MIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGN 133 + + E V P +Y GV VI WN+P + + A AGN Sbjct: 604 YARHMRELQKPLRVGGLPGELSHYIYKSR---GVTAVIAPWNFPLAILAGMVTAAAVAGN 660 Query: 134 SVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER--FDHILYTGST 190 +VV+KP+E S +A L +I + + + + G E E + I +TGS Sbjct: 661 TVVMKPAEQSTVVAWGLMKMIQEAGFPQGVINFLPGYGEEVGEYIVNHKYTTTIAFTGSK 720 Query: 191 GVGKIIMTAAA------KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTC 244 VG IM AA +H+ +E+GGK+ +D + DLD A + + F SGQ C Sbjct: 721 AVGLHIMNRAAVVQPGQQHVKRCIIEMGGKNAVIIDNDADLDEAVDGVIYSAFGFSGQKC 780 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAK-KSRDYGRIISARHFQRVMGLIEGQ-- 301 A ++ + ++ V++L ++ K A+ G ++ + R++G I Sbjct: 781 SAASRVIVLDEVYDRFVDRLVETAKSIEIHPAENPKAYMGPVVDKEAYDRILGTIAEAEK 840 Query: 302 --KVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQRE 359 K+ + G+ + PTI DV + + Q EIFGPV+ ++ ++L++A+ N E Sbjct: 841 NHKLLFKGSVPGGGFFAPPTIFGDVPGDAKLAQAEIFGPVVAVIRAKNLDQALDIANSTE 900 Query: 360 KPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSY-HGKKS 418 L +FS + I ++ E G + N I + PFGG SG+GS G Sbjct: 901 YALTGGVFSRSPANINRVKEELEVGNLYVNRGITGAMVDRHPFGGFKMSGIGSKTGGPDY 960 Query: 419 FETFSHRRSCL 429 + + Sbjct: 961 LKQYMEPACVT 971 >4U3W-A nrPDB Length = 505 Score = 427 bits (1098), Expect = e-120, Method: Composition-based stats. Identities = 116/447 (25%), Positives = 188/447 (42%), Gaps = 19/447 (4%) Query: 2 SKISEAVKRARAAFSS-GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + + AV+ A AA + R R L + I+ + E V A AD + A Sbjct: 59 ALVDSAVQAAHAAQKAGWRDTTPAQRAAWLHKIADGIEARFDEFVAAEVADTGRPVAQAR 118 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 ++ + + + + + Y+ +PLGV+ +I WN P L Sbjct: 119 TLDIARGIANFRTFADLVRTASGEYFETHAADGSELINYVTRKPLGVIGIISPWNLPLLL 178 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVING-GVPETTELLK 178 + A+A GN VV KPSE + + A+LLA ++ L ++ +I+G G E L Sbjct: 179 FTWKVAPALAMGNCVVAKPSEETPSSATLLAEVMHDVGLPPGVFNLIHGHGQNAAGEFLT 238 Query: 179 ERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 D I +TG + G IM A A + V+ ELGGK+ V + D D A + Sbjct: 239 RHPDISAITFTGESRTGSTIMKAVADGVKEVSFELGGKNAAVVFADADFDAAVAGVLRSS 298 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVM 295 F N+GQ C+ + + + I + V LK+ + G + G +IS H +V+ Sbjct: 299 FTNAGQVCLCSERVYVERPIFERFVAALKEQAQALRVGAPEDPATTMGPLISRGHRDKVL 358 Query: 296 GL-----IEGQKVAYGGTGDA------ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVC 344 EG V GG + ++ PTI T + + ++EEIFGPV I Sbjct: 359 SYFRLAVEEGATVVTGGGAPSFGDARDDGAFVMPTIWTGLPDSARCVREEIFGPVCHIAP 418 Query: 345 VRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGG 404 E ++ +N LA ++++ ++ + +G V N V PFGG Sbjct: 419 FDDEAEVVKRVNDSAYGLAASIWTTQLARGHRVAKQIETGIVWVNAWFV--RDLRTPFGG 476 Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLVR 431 SG+G G+ S + +S + VR Sbjct: 477 TKLSGLGREGGRHSLDFYSELTNVCVR 503 >2HG2-A nrPDB Length = 479 Score = 427 bits (1098), Expect = e-120, Method: Composition-based stats. Identities = 120/442 (27%), Positives = 196/442 (44%), Gaps = 17/442 (3%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 +A+ A A P R L + I+E+ E+ + + K Sbjct: 44 EDARKAIDAAERAQPEWEALPAIERASWLRKISAGIRERASEISALIVEEGGK-IQQLAE 102 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 EV + + I+YM + + + P + + LGV I WN+PF L Sbjct: 103 VEVAFTADYIDYMAEWARRYEGEIIQSDRPGEN---ILLFKRALGVTTGILPWNFPFFLI 159 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELLK-- 178 + M A+ GN++V+KPSE + N A A I+ + L + ++ ++ G + L Sbjct: 160 ARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGN 219 Query: 179 ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 + + TGS G+ IM AAK++T V LELGGK+P V + DL++A + I + + Sbjct: 220 PKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVI 279 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKK-SRDYGRIISARHFQRV-- 294 NSGQ C + + I +Q V +L ++++ +G A++ G +I+A +RV Sbjct: 280 NSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQ 339 Query: 295 ---MGLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350 + EG +VA+GG + Y PT+L DV + +M EE FGPVLP+V +LE+ Sbjct: 340 KVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLED 399 Query: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410 AI N + L +++ N V K I G N G SG+ Sbjct: 400 AISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHA--GWRKSGI 457 Query: 411 GSYHGKKSFETFSHRRSCLVRP 432 G GK + + ++ Sbjct: 458 GGADGKHGLHEYLQTQVVYLQS 479 >3EK1-A nrPDB Length = 504 Score = 423 bits (1089), Expect = e-119, Method: Composition-based stats. Identities = 113/439 (25%), Positives = 188/439 (42%), Gaps = 18/439 (4%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 ++ I EA+ + A S + + R L LI ++ + ++ K A Sbjct: 69 VATIKEAIDASAKALSGWAAKTAKERAGILRKWFDLIIANADDIALIMTSEQGKPLAEAR 128 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDE-LYIHSEPLGVVLVIGTWNYPFN 119 EV+Y IE+ ++ D P Q + L + +P+GV I WN+P Sbjct: 129 -GEVLYAASFIEWFAEEAKRVYGD----TIPAPQNGQRLTVIRQPVGVTAAITPWNFPAA 183 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK 178 + + A+AAG +++++P++L+ A L + + + + ++ G E L Sbjct: 184 MITRKAAPALAAGCTMIVRPADLTPLTALALGVLAEKAGIPAGVLQIVTGKAREIGAELT 243 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 + +TGST VG+++M A + ++LELGG +P V + DLD A K Sbjct: 244 SNDTVRKLSFTGSTEVGRLLMAQCAPTIKRISLELGGNAPFIVFDDADLDAAVDGAMVSK 303 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVM 295 + N+GQTCV + I + ++ EKL +KE G + G +I + +V Sbjct: 304 YRNAGQTCVCANRIYVQRGVYDKFAEKLAAKVKELKVGNGTEPGVVIGPMIEEKAITKVK 363 Query: 296 GLIE-----GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350 IE G K+ GG + + P ILT V V +EE FGP+ P+ + EE Sbjct: 364 AHIEDAVSKGAKLITGGK-ELGGLFFEPGILTGVTSDMLVAKEETFGPLAPLFAFDTEEE 422 Query: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410 I N LA Y ++ N ++ G V N ++ + PFGGV SG+ Sbjct: 423 VIAQANDTIFGLAAYFYTENFSRAIRVSEALEYGMVGHNTGLISNEV--APFGGVKQSGL 480 Query: 411 GSYHGKKSFETFSHRRSCL 429 G K E + + Sbjct: 481 GREGSKYGIEEYLETKYIC 499 >1T90-A nrPDB Length = 486 Score = 421 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 104/442 (23%), Positives = 194/442 (43%), Gaps = 17/442 (3%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 I A + A AF + + R + L Q+L+ + ++EL + + KN A Sbjct: 43 EDIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL- 101 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 EV +E +E+ P + + + Y P+GVV I +N+P + Sbjct: 102 GEVGRGIENVEFAAG-APSLMMGDSLASIATDVEAANY--RYPIGVVGGIAPFNFPMMVP 158 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE- 179 AIA GN+ +LKPSE + + L + + L K ++ V+ G +L+ Sbjct: 159 CWMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHP 218 Query: 180 RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 I + GS VG+ + +++L V G K+ V + +L+ I F + Sbjct: 219 EIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGS 278 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298 +G+ C+A + + I ++ + KL++ + + G G +I + +R + I Sbjct: 279 AGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYI 338 Query: 299 -----EGQKVAYGGTGD--AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 EG ++ G + ++ PTI +V + + ++EIF PVL ++ V++L+EA Sbjct: 339 EKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEA 398 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411 I+ N+ E +F+SN I+ +G + N + V + PF G +S G Sbjct: 399 IEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGIN-LGVPAPMAFFPFSGWKSSFFG 457 Query: 412 SYH--GKKSFETFSHRRSCLVR 431 + H GK S + ++ ++ R Sbjct: 458 TLHANGKDSVDFYTRKKVVTAR 479 >3K2W-A nrPDB Length = 497 Score = 421 bits (1082), Expect = e-118, Method: Composition-based stats. Identities = 123/427 (28%), Positives = 186/427 (43%), Gaps = 20/427 (4%) Query: 22 PLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEW 81 + R L I+E + L L A+ K A EV I+Y Sbjct: 70 TARTRQNMLRTFANKIRENKHILAPMLVAEQGKLLSVAEM-EVDVTATFIDYGCDNALTI 128 Query: 82 AADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSE 141 D Q +++YIH P GVV+ I WN+P L + + A+ GN++VLKP++ Sbjct: 129 EGDI---LPSDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKPTQ 185 Query: 142 LSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERF--DHILYTGSTGVGKIIMT 198 + + L I + L + VING + L E I TGST GK I Sbjct: 186 ETPLATTELGRIAKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTGSTVAGKQIYK 245 Query: 199 AAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQN 258 +A+++TPV LELGGK+P V + DLD A WG+F N GQ C + + S+ + Sbjct: 246 TSAEYMTPVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASVYD 305 Query: 259 QIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGT---- 308 + + K +K G+ G + R + ++ +G VA GG Sbjct: 306 EFMAKFLPLVKGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTATV 365 Query: 309 -GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367 G + PT+L DV + V+ EE FGP+LPIV V S+E+AI+F N L+ Y+ Sbjct: 366 EGFEGGCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAYVH 425 Query: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427 + + I + I++ G V N + H G SG G GK E + +++ Sbjct: 426 TQSFANINQAISDLEVGEVYINRGM--GEQHQGFHNGWKQSGFGGEDGKFGLEQYLEKKT 483 Query: 428 CLVRPLM 434 + Sbjct: 484 VYINEAE 490 >3U4J-A nrPDB Length = 528 Score = 421 bits (1082), Expect = e-118, Method: Composition-based stats. Identities = 115/425 (27%), Positives = 195/425 (45%), Gaps = 17/425 (4%) Query: 18 GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQK 77 R + + + LI +++EL + ++ K A E+ + + Y + Sbjct: 79 WPRMSGAERSRLMFKVADLILARQEELALIESLEVGKPIAQAR-GEIGFCADLWSYAAGQ 137 Query: 78 LPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVL 137 + EP+GVV +I WN+PF + + + AI +G +VVL Sbjct: 138 ARALEGQTHNN---IGDDRLGLVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVL 194 Query: 138 KPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER--FDHILYTGSTGVGK 194 KPSE + + LA + + + ++ V+ G ++L E D + +TGS VG Sbjct: 195 KPSEFTSGTSIRLAELAREAGIPDGVFNVVTGYGDPAGQVLAEDPNVDMVAFTGSVRVGT 254 Query: 195 IIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDP 254 + AA+ + V LELGGK P V + DLD A IA+G + N+GQ C++ +L Sbjct: 255 KLGEIAARTVKRVGLELGGKGPQIVFADADLDAAADGIAYGVYHNAGQCCISGSRLLVQE 314 Query: 255 SIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGT 308 I++ ++E+L ++ +G+ + G +IS H ++V + G ++ GG Sbjct: 315 GIRDALMERLLDISRKVAFGDPLNERTKIGAMISEAHAEKVHSYVTAGITSGAELLLGGE 374 Query: 309 --GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYM 366 G A Y APT+ V P + +EEIFGPVL + ++ +EA+ N E L+ + Sbjct: 375 RIGREAGLYYAPTVFAGVTPDMSIAREEIFGPVLSTLTFKTADEAVALANATEFGLSASV 434 Query: 367 FSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRR 426 +S+N + + I +G N VI LP GG SG+G G+ F+ +S + Sbjct: 435 WSTNLETALQTIRRIRAGRCWINSVIDGT--PELPIGGYKKSGLGRELGRYGFDEYSQFK 492 Query: 427 SCLVR 431 V Sbjct: 493 GVHVT 497 >5J77-A nrPDB Length = 508 Score = 419 bits (1077), Expect = e-117, Method: Composition-based stats. Identities = 105/443 (23%), Positives = 195/443 (44%), Gaps = 21/443 (4%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + A+ A AF + R + + + LI++ EL + + K A Sbjct: 40 DDVDRAIDAAEDAFWAWNDLGSVERSKIIYRAKELIEKNRAELENIIMEENGKPVKEA-K 98 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 EEV V+++I+Y + + + + +++ + P G+V+ + WN+P + Sbjct: 99 EEVDGVIDQIQYYAEWARKLNGEVVEGT---SSHRKIFQYKVPYGIVVALTPWNFPAGMV 155 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLA-TIIPQYLDKDLYPVINGGVPETTELLKER 180 + + A+ GN+VVLKPS + A + + + K + I G E + + E Sbjct: 156 ARKLAPALLTGNTVVLKPSSDTPGSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDYIVEH 215 Query: 181 --FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 + I TGST G+ IM A+ ++ + LELGGK+P V K+ D+D A + + W K+ Sbjct: 216 KKVNLITMTGSTATGQRIMQKASANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKYW 275 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298 N+GQ+C+A + + I + + + + ++ D K + D G +I+ Q ++ Sbjct: 276 NAGQSCIAAERLYVHEDIYDTFMSRFVELSRKLALGDPKNA-DMGPLINKGALQATSEIV 334 Query: 299 E-----GQKVAYGGTGDA------ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 E G K+ +GG+ + + PTI+ + D +S + QEEIF PV+ + S Sbjct: 335 EEAKESGAKILFGGSQPSLSGPYRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARKISS 394 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 +EE N + LA Y+F+ + +I + G + N + G Sbjct: 395 VEEMYDLANDNKYGLASYLFTKDPNIIFEASERIRFGELYVN--MPGPEASQGYHTGFRM 452 Query: 408 SGMGSYHGKKSFETFSHRRSCLV 430 +G K + ++ V Sbjct: 453 TGQAGEGSKYGISEYLKLKNIYV 475 >4ZZ7-A nrPDB Length = 501 Score = 417 bits (1072), Expect = e-117, Method: Composition-based stats. Identities = 97/444 (21%), Positives = 191/444 (43%), Gaps = 21/444 (4%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 + +A+ A+ AF + R P R + + + L+++ E+ + + K + E Sbjct: 45 VEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEICRLIGEEHGK-IAHDAMGE 103 Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123 + +E +EY + P + + +P+GVV I +N+P + + Sbjct: 104 LQRGIENVEYACGAPELLKGEHSRNVGPGI---DSWSEFQPMGVVAGITPFNFPVMVPLW 160 Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL-KERF 181 AI GN VLKPSE + +A ++ + L + V+NG LL +R Sbjct: 161 MFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDRV 220 Query: 182 DHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSG 241 + + GST + + I A+ + G K+ V + D+D A ++ F +SG Sbjct: 221 KAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSG 280 Query: 242 QTCVAPDYIL-CDPSIQNQIVEKLKKSLKEFYGED-AKKSRDYGRIISARHFQRVMGLI- 298 + C+A + + + +V K+ +++++ D+G +I+ +H ++V+G I Sbjct: 281 ERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYIN 340 Query: 299 ----EGQKVAYGGTGD-----AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 +G + G ++ T++ V P+ QEEIFGPVL +V V +++ Sbjct: 341 SAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQ 400 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 +A+ I+ E +F+ + + + G V N + + + + FGG S Sbjct: 401 DAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGIN-IPLPVPVAYHSFGGWKRSL 459 Query: 410 MGSYH--GKKSFETFSHRRSCLVR 431 G H G + ++ R++ R Sbjct: 460 FGDLHAYGPDAVRFYTKRKTVTQR 483 >5UCD-A nrPDB Length = 457 Score = 416 bits (1071), Expect = e-117, Method: Composition-based stats. Identities = 165/434 (38%), Positives = 251/434 (57%), Gaps = 7/434 (1%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 +KI +A F++ T + FR Q LE L+ + ++ L ALA DL K + Sbjct: 28 AKIDSLFSAQKAYFATRATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVVDL 87 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 E+ VL EI++ + L EW A V E Y+ EP GV +IG +NYP NLT Sbjct: 88 AEIGAVLHEIDFALAHLDEWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVNLT 147 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERF 181 + P++GAI GN+ ++KPSE + ++++ II + + VI GG E + LL F Sbjct: 148 LTPLIGAIIGGNTCIIKPSETTPETSAVIEKIIAEAFAPEYVAVIQGGRDENSHLLSLPF 207 Query: 182 DHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSG 241 D I +TGS VGK++M AAAKHLTPV LELGGK P V + DLD ++ +GKF+NSG Sbjct: 208 DFIFFTGSPNVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKFINSG 267 Query: 242 QTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG- 300 QT +APDY+ S+++ ++E+L + +K + + G++++ R QR++ L+E Sbjct: 268 QTXIAPDYLYVHYSVKDALLERLVERVK----TELPEINSTGKLVTERQVQRLVSLLEAT 323 Query: 301 -QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQ-R 358 +V G D + R ++ T++ V+ P+M EE+FGP+LP++ S+ AI +N+ Sbjct: 324 QGQVLVGSQADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNKHH 383 Query: 359 EKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKS 418 KPLA+Y+F + V K +I + SG N V++H LPFGG+G SGMG YHG S Sbjct: 384 PKPLAVYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGEYHGHFS 443 Query: 419 FETFSHRRSCLVRP 432 + TF+H++S + P Sbjct: 444 YLTFTHKKSVRIVP 457 >3B4W-A nrPDB Length = 495 Score = 415 bits (1067), Expect = e-116, Method: Composition-based stats. Identities = 116/424 (27%), Positives = 191/424 (45%), Gaps = 18/424 (4%) Query: 18 GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQK 77 + P R + A +++ E++ LAA+ + + + + Y Sbjct: 64 WPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAGA 123 Query: 78 LPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVL 137 + +T + + EP+GVV I WN P L + + A+ AG ++VL Sbjct: 124 ADKVT----WTETRTGSYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVL 179 Query: 138 KPSELSENMASLLATIIPQ-YLDKDLYPVINGGVPETTELLK-ERFDHILYTGSTGVGKI 195 KP+ + A+ LA + + L + + V+ GG+ L D +TGS+ VG+ Sbjct: 180 KPAAETPLTANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVGRE 239 Query: 196 IMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPS 255 + AA+ L P TLELGGKS + ++ DL A + + MN+GQ CV IL S Sbjct: 240 VGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRS 299 Query: 256 IQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGTG 309 ++IV + + G + + G +IS + RV G I EG ++ GG Sbjct: 300 RYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGR 359 Query: 310 DAA---TRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYM 366 +I PT+ DVD + + QEEIFGPVL I+ + E+AI N LA + Sbjct: 360 PEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSV 419 Query: 367 FSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRR 426 ++++ K+ + +G N + PFGG NSG+G +G + E F+ ++ Sbjct: 420 WTTDVPKGIKISQQIRTGTYGIN---WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQK 476 Query: 427 SCLV 430 S L+ Sbjct: 477 SVLL 480 >4OGD-A nrPDB Length = 465 Score = 414 bits (1064), Expect = e-116, Method: Composition-based stats. Identities = 106/448 (23%), Positives = 188/448 (41%), Gaps = 17/448 (3%) Query: 4 ISEAVKRARAAFSSGRTRP-LQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 +++ ++RA + R L+ R QL + +++ + + D+ K + Sbjct: 25 LADVLERAHLLYKKWRKEDHLEERKAQLHQVANILRRDRDKYAEIMTKDMGK-LFTEAQG 83 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 EV + +Y K E+ P+E T + Y + GV+L + WN+P+ + Sbjct: 84 EVDLCADIADYYADKADEFLMSTPLE----TDSGQAYYLKQSTGVILAVEPWNFPYYQIM 139 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE-R 180 + GN +VLK + + A ++ + + + + ++++ + R Sbjct: 140 RVFAPNFIVGNPMVLKHASICPRSAQSFEELVLEAGAEAGSITNLFISYDQVSQVIADKR 199 Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240 + TGS G I A K+L TLELGG + + D D + + + + N+ Sbjct: 200 VVGVCLTGSERGGASIAEEAGKNLKKTTLELGGDDAFIILDDADWDQLEKVLYFSRLYNA 259 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQRVMGLIE 299 GQ C + + ++ E L K K G+ + SA+ V+ I+ Sbjct: 260 GQVCTSSKRFIVLDKDYDRFKELLTKVFKTAKWGDPMDPETTLAPLSSAQAKADVLDQIK 319 Query: 300 -----GQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQ 353 G ++ YGG D ++ PTI+ + +P+ +EIFGPV I V S EEAI+ Sbjct: 320 LALDHGAELVYGGEAIDHPGHFVMPTIIAGLTKDNPIYYQEIFGPVGEIYKVSSEEEAIE 379 Query: 354 FINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSY 413 N L +FSSN + K + A+ +G N +L LPFGG+ +SG G Sbjct: 380 VANDSNYGLGGTIFSSNQEHAKAVAAKIETGMSFINSGWT--SLPELPFGGIKHSGYGRE 437 Query: 414 HGKKSFETFSHRRSCLVRPLMNDEGLKV 441 + F +F + + N+ KV Sbjct: 438 LSELGFTSFVNEHLIYIPNKTNNSNTKV 465 >3VZ3-A nrPDB Length = 457 Score = 411 bits (1058), Expect = e-115, Method: Composition-based stats. Identities = 109/439 (24%), Positives = 192/439 (43%), Gaps = 16/439 (3%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 ++I + +A+ AF + R R Q LE +++ + + ++ K + Sbjct: 26 AEIDAKLAKAQEAFQAYRRTSFSQRRQWLENAAAILERDTSKFAEIMTTEMGKT-HQSAI 84 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 E Y + ++ A+E E TQ E Y+ +PLG++L + WN+PF Sbjct: 85 AEAEKSALVCRYYAEHGEQFLANEYTE----TQATESYVCYQPLGILLAVMPWNFPFWQV 140 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE- 179 + A+ AGN VLK + A + I+ + ++ + G + +++K+ Sbjct: 141 FRFAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQTLLIGASQVEQVIKDP 200 Query: 180 RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 R TGS G + + A + + P LELGG P V + DLD A + MN Sbjct: 201 RVKAATLTGSEPAGASLASLAGQEIKPTLLELGGSDPFVVFPSADLDEAVEVGTVARTMN 260 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRV---- 294 +GQ+ +A + +I + +EKL G+ D G + + Q + Sbjct: 261 NGQSAIAAKRFILHEAIAAEFLEKLHLKFASLKIGDPMAPETDIGPLATEGILQDISRQV 320 Query: 295 -MGLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAI 352 + G K+ GG D A + PTILT++ P + ++QEE+F PV + V+ L++AI Sbjct: 321 DQAVAAGAKILLGGRPLDRAGYFYPPTILTEIPPGAKILQEELFAPVAMVFTVKDLDQAI 380 Query: 353 QFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGS 412 N L ++++ ++ I E +G V N ++ + LPFGG SG G Sbjct: 381 ALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGMV--KSDPRLPFGGTKRSGYGR 438 Query: 413 YHGKKSFETFSHRRSCLVR 431 G TF + ++ ++ Sbjct: 439 ELGLAGIRTFVNAKTVWLK 457 >4JZ6-A nrPDB Length = 500 Score = 411 bits (1058), Expect = e-115, Method: Composition-based stats. Identities = 106/453 (23%), Positives = 186/453 (41%), Gaps = 24/453 (5%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKN-EWNA 59 ++ +A + A AF + + R + L + +++ + + + +A ++ + W Sbjct: 56 VTDAIKAAQAAEEAFKTWKDVGPSERRRLLLKVADVMESKTPKFIEVMAMEVGASALWAG 115 Query: 60 YYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQ-QDELYIHSEPLGVVLVIGTWNYPF 118 + V A E P + + +P+G +L I WN Sbjct: 116 FN--VHASANVFREAAS----LATQIQGETIPTDKAETLSMTLRQPVGPILSIVPWNGTA 169 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVIN---GGVPETT 174 L + + + GN+VV K SE S +L+ + + L + +N PE Sbjct: 170 VLAARAIAYPLVCGNTVVFKGSEFSPATHALITQCVQEAGLPAGVLNYLNSSPDRSPEIA 229 Query: 175 ELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRI 232 + L + I +TGST VG II AA+HL LELGGKSP V + D++ A + Sbjct: 230 DALISAKEIRRINFTGSTRVGSIIAQKAAQHLKRCLLELGGKSPLIVLDDADINAAVKAA 289 Query: 233 AWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRD--YGRIISARH 290 +G F+ GQ C++ + ++ D I ++ V + + + D + D G ++S Sbjct: 290 VFGSFLFQGQICMSTERLVVDEKIADEFVARFVEKTERLSVGDPCLTGDCIIGPMVSPNS 349 Query: 291 FQRVMGLI-----EGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCV 345 +R+ GL +G KV GG A + TIL V + EE FGP+ ++ Sbjct: 350 GERINGLFKDAIDKGAKVVCGGMAQGAV--MPATILDHVKSDMRIYDEETFGPITVVIRC 407 Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405 + EAI+ N L+ +F + ++ G V N V P+GG Sbjct: 408 KGEAEAIRIANDSVYGLSSGVFGRDINRALRVGMSIEYGCVHINGSTVQ-NEAQAPYGGT 466 Query: 406 GNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEG 438 N+G G + G+ + F+ + + P Sbjct: 467 KNTGYGRFDGRAVIDEFTELKWLTIEPFEQQYP 499 >6MVR-A nrPDB Length = 767 Score = 411 bits (1058), Expect = e-115, Method: Composition-based stats. Identities = 112/435 (25%), Positives = 181/435 (41%), Gaps = 28/435 (6%) Query: 1 MSKISEAVKRA--------RAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADL 52 ++++S+A + R A + + R + L AL RL+Q+ + D Sbjct: 59 LAQVSQATQADVDAAVKAARKAQPAWA-KDGAARARVLYALARLLQKHARLFAVLETLDN 117 Query: 53 HKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIG 112 K A +V + + P PLGV + Sbjct: 118 GKPIREARDIDVPLAQRHFYHHAGYAQLMGTEMP--------------DRAPLGVCGQVI 163 Query: 113 TWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVP 171 WN+P + + A+A GN+VVLKP+E + A L A I Q + + ++ G Sbjct: 164 PWNFPLLMLAWKIAPALAMGNTVVLKPAEWTPLTALLFADICGQAGVPAGVVNIVTGDGA 223 Query: 172 ETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231 ++ + D + +TGST VG+ I A A ++LELGGK P V + D+D A Sbjct: 224 VGEMIVTAQVDKVAFTGSTAVGRRIREATAGTGKALSLELGGKGPYVVCDDADIDSAVEG 283 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARH 290 + + N GQ C A +L I + KL+ + G+ K D G ++ Sbjct: 284 LVDAIWFNQGQVCCAGSRLLVQEGIADVFHAKLRARMDSLRIGDPLDKCIDIGAMVHPDQ 343 Query: 291 FQRVMGLIEGQKV-AYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 RV ++ T A Y PT+++ + P SP+MQ+EIFGPVL R+ Sbjct: 344 LARVRDMVAANTDGEVYQTAVPAGCYYPPTLISGLAPASPLMQQEIFGPVLVSTTFRTPA 403 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 EA++ N LA ++S N + + + +G V N ++ + PFGGV SG Sbjct: 404 EAVEIANNTAYGLAASVWSENVNLALDLAPKLVAGIVWING--TNMMDAAAPFGGVRESG 461 Query: 410 MGSYHGKKSFETFSH 424 G G + ++ Sbjct: 462 FGREGGWEGLAGYTR 476 Score = 90.3 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 38/205 (18%), Positives = 68/205 (33%), Gaps = 10/205 (4%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 + AV+ AA S R Q L + + + E + K Sbjct: 540 DLRNAVEAMNAA-SGWSRTTGHLRAQILYFIGENLSARADEFANRIKDMTGK----DGKA 594 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 EV ++ + WA + + EP+G + ++ P + Sbjct: 595 EVAASIDRL----FSAAAWADKYDGQVKGVPLRGVALAMKEPVGKIGILCPDAAPLLGLV 650 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERF 181 M AIA GN V L SE A+ ++ + + ++ G + E + Sbjct: 651 SLMAPAIAMGNRVTLAASEAFPLAATDFYQVLDTSDVPAGVVNILTGAHADLAEPMARHL 710 Query: 182 DHILYTGSTGVGKIIMTAAAKHLTP 206 D G +G ++I A+A +L Sbjct: 711 DLDAVWGLSGHAQVIEAASAGNLKR 735 >5TJR-A nrPDB Length = 531 Score = 410 bits (1055), Expect = e-115, Method: Composition-based stats. Identities = 113/446 (25%), Positives = 193/446 (43%), Gaps = 21/446 (4%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + +A+ A+AAF + R P R Q L ++L++ E+ +V ++ + K +A Sbjct: 73 ETMQQAIDAAKAAFPAWRNTPPAKRAQVLFRFKQLLEANEERIVKLISEEHGKTIEDAA- 131 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 E+ +E +EY PE E + + +P+GVV I +N+P + Sbjct: 132 GELKRGIENVEY-ATAAPEILKGEYSRNV--GPNIDAWSDFQPIGVVAGITPFNFPAMVP 188 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL-KE 179 + AIA GN+ +LKPSE + L+A + + L K + V++G L+ Sbjct: 189 LWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGLPKGVLNVVHGDKGAVDALIEAP 248 Query: 180 RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 + + GST + + I + K V G K+ + + DLD A + + + Sbjct: 249 EVKALSFVGSTPIAEYIYSEGTKRGKRVQALGGAKNHAVLMPDADLDNAVSALMGAAYGS 308 Query: 240 SGQTCVAPDYIL-CDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGL 297 G+ C+A + I + +V+KL +K G D G +++ +V G Sbjct: 309 CGERCMAISVAVCVGDQIADALVQKLVPQIKGLKIGAGTSCGLDMGPLVTGAARDKVTGY 368 Query: 298 IE-----GQKVAYGGTG-----DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 I+ G ++ G G ++ T+ V P+ + +EEIFGPVL IV V S Sbjct: 369 IDTGVAQGAELVVDGRGYKVAGHENGFFLGGTLFDRVTPEMTIYKEEIFGPVLCIVRVNS 428 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 LEEA+Q IN E +F+ + + + E G V N V + + + FGG Sbjct: 429 LEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEVGMVGVN-VPLPVPVAYHSFGGWKR 487 Query: 408 SGMGSYH--GKKSFETFSHRRSCLVR 431 S G H G ++ R++ R Sbjct: 488 SLFGDLHAYGPDGVRFYTKRKAITQR 513 >6FK3-A nrPDB Length = 536 Score = 406 bits (1045), Expect = e-114, Method: Composition-based stats. Identities = 118/451 (26%), Positives = 192/451 (42%), Gaps = 36/451 (7%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + +A +AR AF+ P R Q L L ++++ ++ L + ++ K A Sbjct: 56 DLVRKAALKAREAFAEWSRTPAPIRGQVLFNLVKILEREKPTLTRLMVREVGKTPKEAA- 114 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQD-ELYIHSEPLGVVLVIGTWNYPFNL 120 +V ++ + + + P +D EL+ PLGVV +I N+P + Sbjct: 115 GDVQEAIDTALFFASEGRRL----YGQTVPSEMRDKELFTFRRPLGVVGIITAGNFPIAV 170 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPE-TTELLK 178 ++ A+ GN+VV KPSE + ++ + A + + L + V+ GG T + + Sbjct: 171 PSWKLIPAVLTGNTVVWKPSEDAPTLSFVFAKLFEEAGLPPGVLNVVFGGGKGSTGQWMV 230 Query: 179 ERFD-----HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 E D +TGST VG+ I A ++L TLELGGK+P V ++ DLD+A Sbjct: 231 ELMDEGLFQKFAFTGSTQVGRWIGEVAGRNLIRPTLELGGKNPLVVMRDADLDLAVEGAW 290 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSL-KEFYGEDAK-KSRDYGRIISARHF 291 W F GQ C + IL D I + + + + G YG I+ R F Sbjct: 291 WSAFATGGQRCTSAGNILVDAPIYEEFKRRFLERVEATLVGNPLLHPEVTYGPFINERFF 350 Query: 292 QRVMGL-----IEGQKVAYGGTG-------------DAATRYIAPTILTDVDPQSPVMQE 333 R EG ++ +G A Y PT+ +V P + + E Sbjct: 351 ARWQEHYRVGEAEGARLLFGRGRITRENPYPRFLGDPEAGLYGWPTVW-EVRPGTRLFTE 409 Query: 334 EIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIV 393 E+FGP + +V V +EEAI N L+ +++++ +G + N+ V Sbjct: 410 EVFGPTINLVKVDGIEEAIAVANSTPYGLSSAIYTNHRHWAYLFKVGIRAGMTSINNATV 469 Query: 394 HITLHSLPFGGVGNSGM-GSYHGKKSFETFS 423 H LPFGGV SG G G E ++ Sbjct: 470 GAEAH-LPFGGVKASGNGGRESGIWVLEEYT 499 >2W8P-A nrPDB Length = 487 Score = 406 bits (1044), Expect = e-114, Method: Composition-based stats. Identities = 113/429 (26%), Positives = 192/429 (44%), Gaps = 20/429 (4%) Query: 15 FSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYM 74 F R + R L L+ + + +L + A+ K A + E++Y +E+ Sbjct: 61 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWF 119 Query: 75 IQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNS 134 ++ D + TP + L + +P+GV VI WN+P + + + A+AAG + Sbjct: 120 SEEARRVYGD--IIHTPAKDRRAL-VLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCT 176 Query: 135 VVLKPSELSENMASLLATIIPQY-LDKDLYPVIN---GGVPETTELLKER--FDHILYTG 188 VV+KP+E + A LA + Q + +Y VI E E + I +TG Sbjct: 177 VVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTG 236 Query: 189 STGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPD 248 ST GKI++ AA + V++ELGG +P V + ++D A KF N+GQT V + Sbjct: 237 STTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSN 296 Query: 249 YILCDPSIQNQIVEKLKKSLKE--FYGEDAKKSRDYGRIISARHFQRVM-----GLIEGQ 301 L I + V+ +++K+ G ++ G +I+ + ++V + +G Sbjct: 297 QFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGA 356 Query: 302 KVAYGGTGDAAT-RYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360 V GG + PT+L +V EE FGP+ P++ + EEAI N + Sbjct: 357 TVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADV 416 Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420 LA Y +S + I ++ + G V N+ + I+ PFGGV SG+G K + Sbjct: 417 GLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGID 474 Query: 421 TFSHRRSCL 429 + + Sbjct: 475 EYLELKYVC 483 >2JG7-A nrPDB Length = 510 Score = 405 bits (1042), Expect = e-113, Method: Composition-based stats. Identities = 92/445 (20%), Positives = 197/445 (44%), Gaps = 18/445 (4%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 +++ E V++ R A+ P R + + + ++++ + L ++ ++ K + Sbjct: 56 LAEYEETVQKTREAWKMWADIPAPKRGEIVRQIGDALRKKIKVLGSLVSLEMGK-IYVEG 114 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 EV ++ +Y + + P E + P+G+V +I +N+P + Sbjct: 115 VGEVQEYVDVCDYAVGLSRMIGGPVLPSERPGHALIEQW---NPVGLVGIITAFNFPVAV 171 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPETTE 175 A+ GN + K + + + + I+ + L+++ P + GG T Sbjct: 172 YGWNNAIALTCGNVCLWKGAPTTPLTSVAVTKIVAEVLEQNNLPGAICSMTCGGADIGTA 231 Query: 176 LL-KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 + ER D + +TGST VGK++ + LELGG + V ++ DL++ + Sbjct: 232 MAKDERVDLLSFTGSTHVGKMVAMMVQERFGRKLLELGGNNAIIVFEDADLNLVVPSAVF 291 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293 +GQ C ++ S+ + +VE++ K+ K+ G+ S YG + + + + Sbjct: 292 ASVGTAGQRCTTTRRLMLHESVHDAVVERIAKAYKQVRIGDPWDPSTLYGPLHTKQAVDQ 351 Query: 294 VMGLIE-----GQKVAYGGT-GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 + IE G + GG D Y+ PTI+T + +P++ E F P+L ++ ++ Sbjct: 352 YLAAIEQAKQQGGTLVCGGKVMDRPGNYVEPTIITGLAHDAPIVHTETFVPILYVLKFKT 411 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKK-MIAETSSGGVAANDVIVHITLHSLPFGGVG 406 EEA + N+ ++ L+ +F+ + + + + + S G+ ++ FGG Sbjct: 412 EEEAFAWNNEVQQGLSSSIFTKDLGRVFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEK 471 Query: 407 NSGMGSYHGKKSFETFSHRRSCLVR 431 ++G G G S++ + R +C + Sbjct: 472 HTGGGRESGSDSWKQYMRRSTCTIN 496 >2QE0-A nrPDB Length = 475 Score = 404 bits (1038), Expect = e-113, Method: Composition-based stats. Identities = 112/438 (25%), Positives = 188/438 (42%), Gaps = 16/438 (3%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 ++ A+ A + R R L + ++ ++++ L+ ++ K + + Sbjct: 40 EEVDYVYASAKKAQPAWRALSYIERAAYLHKVADILMRDKEKIGAILSKEVAKG-YKSAV 98 Query: 62 EEVVYVLEEIEYMIQKLPEWAAD--EPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 EVV E I Y ++ + E +++ + EP+G+VL I +NYP N Sbjct: 99 SEVVRTAEIINYAAEEGLRMEGEVLEGGSFEAASKKKIAVVRREPVGLVLAISPFNYPVN 158 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK 178 L + A+ AGN + KP LLA + L ++ I G E + + Sbjct: 159 LAGSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEAGLPAGVFNTITGRGSEIGDYIV 218 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 E + I +TGSTG+G+ I A + P+ L LGGK V ++ DL++ + I G Sbjct: 219 EHQAVNFINFTGSTGIGERIGKMAG--MRPIMLALGGKDSAIVLEDADLELTAKNIIAGA 276 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMG 296 F SGQ C A +L S+ +++VEK+++ + + + D +I + V G Sbjct: 277 FGYSGQRCTAVKRVLVMESVADELVEKIREKVLALTIGNPEDDADITPLIDTKSADYVEG 336 Query: 297 LI-----EGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 LI +G I P + V + EE FGPVLPI+ V S+EEA Sbjct: 337 LINDANDKGATALT--EIKREGNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEA 394 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411 I+ N+ E L +F+++ + + G V N+ + PF G SG G Sbjct: 395 IEISNKSEYGLQASIFTNDFPRAFGIAEQLEVGTVHINNK-TQRGTDNFPFLGAKKSGAG 453 Query: 412 SYHGKKSFETFSHRRSCL 429 K S E + +S + Sbjct: 454 IQGVKYSIEAMTTVKSVV 471 >4DNG-A nrPDB Length = 485 Score = 403 bits (1037), Expect = e-113, Method: Composition-based stats. Identities = 106/444 (23%), Positives = 195/444 (43%), Gaps = 12/444 (2%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 ++ +A A+ A + R L+ + + E +++ +A + + Sbjct: 45 QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKSTI- 103 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 E+ + ++ + E + V + + +++Y PLGV+ I +N+P NL++ Sbjct: 104 ELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIY--RLPLGVISSISPFNFPMNLSM 161 Query: 123 QPMVGAIAAGNSVVLKPSELSENMA-SLLATIIP-QYLDKDLYPVINGGVPETTE--LLK 178 + + AIA GNSVV KP + +++A L + V+ V E + L Sbjct: 162 RSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGMLTN 221 Query: 179 ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 I +TGST VG+ I A + + LELGG +P V + D+D A +GKF+ Sbjct: 222 PIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAIFGKFI 281 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGL 297 + GQ C+ + I+ + ++ VEK +K+ YG+ G +I+ R ++ + + Sbjct: 282 HQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQIEKALEI 341 Query: 298 IEGQK---VAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQF 354 IE K + G + P + D S + Q E+F P+ I+ S +EAI Sbjct: 342 IEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKAGSDQEAIDM 401 Query: 355 INQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYH 414 N E L+ +F+S+ + +K + SG ND V+ + ++ FGG SG+G + Sbjct: 402 ANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDS-PNIAFGGNKASGVGRFG 460 Query: 415 GKKSFETFSHRRSCLVRPLMNDEG 438 E F+ + ++ Sbjct: 461 NPWVVEEFTVTKWISIQKQYRKYP 484 >4YWE-A nrPDB Length = 487 Score = 403 bits (1036), Expect = e-113, Method: Composition-based stats. Identities = 116/426 (27%), Positives = 183/426 (42%), Gaps = 18/426 (4%) Query: 18 GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQK 77 R + L L + + +EL A D K A + + E+ Sbjct: 66 WGAASAAERGRVLMRLSARVTDSIEELAAIEARDTGKPLKQARAD-AAALARYFEFYAGA 124 Query: 78 LPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVL 137 + E P + EP GV I WNYP + + + A+AAGN+ V+ Sbjct: 125 ADKL----HGETLPYQAGYTVLTVREPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVV 180 Query: 138 KPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER--FDHILYTGSTGVGK 194 KP+E + +A + + L ++ G E L DHI +TGS GK Sbjct: 181 KPAEDACLSVLRVAELAAEAGLPAGALNIVTGYGHEAGAALARHPGIDHISFTGSPATGK 240 Query: 195 IIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDP 254 ++ AA++ PVTLELGGKSP V + DLD A + N GQTC A +L + Sbjct: 241 LVTQMAAENHVPVTLELGGKSPQIVFADADLDAALPVLVSAIVQNGGQTCSAGSRVLIER 300 Query: 255 SIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI-----EGQKVAYGGT- 308 ++ +VE+L + ++ D G +I+A+ QRV + +G +A G Sbjct: 301 AVYEPLVERLATAFNGLRVGPSRADLDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQV 360 Query: 309 ---GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALY 365 + Y AP +L DV P + QEE+FGPVL + +EA+ N L Sbjct: 361 VADAPESGFYQAPALLRDVPPSHRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAG 420 Query: 366 MFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHR 425 +++ + ++ +G V N+ + LPFGGVG+SG G G ++ F+ Sbjct: 421 IWTRDGARQMRLARRLRAGQVFINNYGAGGGV-ELPFGGVGHSGHGREKGFEALYGFTAL 479 Query: 426 RSCLVR 431 ++ +R Sbjct: 480 KTIAIR 485 >5NNO-A nrPDB Length = 546 Score = 403 bits (1035), Expect = e-112, Method: Composition-based stats. Identities = 212/470 (45%), Positives = 296/470 (62%), Gaps = 18/470 (3%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + I V + R AF+ R L+ R Q L +L L++E E A+ D ++ Sbjct: 14 LENIPVIVSKCREAFNDDANRDLKKRKQVLRSLLNLVEENTDEFCKAIHRDRRRHRDETV 73 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 E++ + E+ ++I+ + E+ D+ + EPLGVVLVIGTWNYP L Sbjct: 74 VMEILPLRNEVWHLIEHMDEYVKPVKPTMEGAAALDDCELQYEPLGVVLVIGTWNYPLLL 133 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180 +QP++GA+AAGN+ V+KPSEL+ A LL ++P+Y+ D+ ++NGGV ETT +LKER Sbjct: 134 ILQPLLGALAAGNTAVIKPSELAPATAELLTKLLPKYVSSDVVGIVNGGVSETTAVLKER 193 Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNC--DLDVACRRIAWGKFM 238 FDHILYTGS V +I+M AAAKHLTPVTLELGGKSP VD C ++ V RI WGK + Sbjct: 194 FDHILYTGSARVAEIVMAAAAKHLTPVTLELGGKSPVVVDDTCADNMKVVAERIMWGKII 253 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGED----------------AKKSRDY 282 N+GQT +APDY++ + S+++ +V+ L ++ K G+ + DY Sbjct: 254 NAGQTSIAPDYVVVEKSMESVLVDALAEARKAMLGDKFLKVLKGELLVKQKQQFLEESDY 313 Query: 283 GRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI 342 RI++A HFQR+M ++G KVA GG D AT IAPTILT++DP PVMQEEIFGP+LP+ Sbjct: 314 PRIVNASHFQRLMEFMKGGKVAVGGEADEATLTIAPTILTNIDPTHPVMQEEIFGPILPV 373 Query: 343 VCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPF 402 + + ++ ++ IN REKPLALY+FS+N + I+ + + TSSG V NDV+VH LPF Sbjct: 374 LTYENEKDILKIINSREKPLALYVFSNNKRFIRGVESRTSSGAVVVNDVVVHAGADGLPF 433 Query: 403 GGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQ 452 GGVG SGMG+YHG+ SFETFSHRR + R + VR+PP ++ Sbjct: 434 GGVGRSGMGAYHGRYSFETFSHRRPVMRRGFLFSSIDTVRFPPYTTAKSR 483 >5X5U-A nrPDB Length = 505 Score = 401 bits (1031), Expect = e-112, Method: Composition-based stats. Identities = 106/429 (24%), Positives = 184/429 (42%), Gaps = 16/429 (3%) Query: 12 RAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEI 71 ++ F + R P R + L++E+ + + + K A EV+ + I Sbjct: 80 QSGFEAWRKVPAHERAATMRKAAALVRERADAIAQLMTQEQGKPLTEARV-EVLSAADII 138 Query: 72 EYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAA 131 E+ + P+ + + EP+G V WN+P N ++ + A+A Sbjct: 139 EWFADEGRRVYGRI---VPPRNLGAQQTVVKEPVGPVAAFTPWNFPVNQVVRKLSAALAT 195 Query: 132 GNSVVLKPSELSENM-ASLLATIIPQYLDKDLYPVINGGVPETTELLKER--FDHILYTG 188 G S ++K E + A+LL + + + ++ G E + L + +TG Sbjct: 196 GCSFLVKAPEETPASPAALLRAFVDAGVPAGVIGLVYGDPAEISSYLIPHPVIRKVTFTG 255 Query: 189 STGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPD 248 ST VGK + + A H+ T+ELGG +P V ++ D+ +A + KF N+GQ C++P Sbjct: 256 STPVGKQLASLAGLHMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQVCISPT 315 Query: 249 YILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE-----GQK 302 L SI+++ L K + G ++ G + + R + +I+ G Sbjct: 316 RFLVHNSIRDEFTRALVKHAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNARKVGAS 375 Query: 303 VAYGGTGDAA-TRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKP 361 + GG + + APT++ +V + V E FGPV I LEEAI N+ Sbjct: 376 IETGGERIGSEGNFFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEANRLPFG 435 Query: 362 LALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFET 421 LA Y F+ + + + G + N +PFGGV +SG GS G ++ E Sbjct: 436 LAGYAFTRSFANVHLLTQRLEVGMLWINQPATP--WPEMPFGGVKDSGYGSEGGPEALEP 493 Query: 422 FSHRRSCLV 430 + +S V Sbjct: 494 YLVTKSVTV 502 >3PRL-A nrPDB Length = 505 Score = 399 bits (1027), Expect = e-112, Method: Composition-based stats. Identities = 116/444 (26%), Positives = 192/444 (43%), Gaps = 16/444 (3%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 ++++A++ A+ A + RP+ R+ L A L++E+++ + + ++ K + Sbjct: 49 EEVNDAIQGAKDAQKIWKIRPIHERVDLLYAWADLLEERKEIIGELIMHEVAKP-KKSAI 107 Query: 62 EEVVYVLEEIEYMIQKLPEWAAD--EPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119 EV + I + + + + + + + + EPLGVVL I +NYP N Sbjct: 108 GEVSRTADIIRHTADEALRLNGETLKGDQFKGGSSKKIALVEREPLGVVLAISPFNYPVN 167 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLAT-IIPQYLDKDLYPVINGGVPETTELLK 178 L + A+ GN+VV KP+ + + + + V+ G + L Sbjct: 168 LAAAKIAPALVTGNTVVFKPATQGSLSGIKMVEALADAGAPEGIIQVVTGRGSVIGDHLV 227 Query: 179 ER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236 E D I +TG T G+ I A + PV LELGGK P V + DL + +I G Sbjct: 228 EHPGIDMITFTGGTTTGERISEKAK--MIPVVLELGGKDPAIVLDDADLKLTASQIVSGA 285 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMG 296 F SGQ C A + S+ +Q+V +K+ +++ + D +I + + G Sbjct: 286 FSYSGQRCTAIKRVFVQDSVADQLVANIKELVEQLTVGSPEDDADITPVIDEKSAAFIQG 345 Query: 297 LIE-----GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 LI+ G + G ++PT+L DV P V EE FGPVLPI+ V+ EA Sbjct: 346 LIDDALENGATLLSGNKRQ--GNLLSPTLLDDVTPAMRVAWEEPFGPVLPIIRVKDANEA 403 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411 I NQ + L +F+ + + G V N H PF GV SG+G Sbjct: 404 ISLSNQSDYGLQASIFTKDTDRAINIGKHLEVGTVHINAKTERGPDH-FPFLGVKKSGLG 462 Query: 412 SYHGKKSFETFSHRRSCLVRPLMN 435 K S + + R ++ N Sbjct: 463 VQGIKPSLLSMTRERVTVLNLAEN 486 >2J5N-A nrPDB Length = 516 Score = 398 bits (1022), Expect = e-111, Method: Composition-based stats. Identities = 108/429 (25%), Positives = 186/429 (43%), Gaps = 18/429 (4%) Query: 15 FSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYM 74 F + + P + R + L L++ +++EL L ++ KN W +V ++ IEY Sbjct: 87 FKTWKDWPQEDRSRLLLKAAALMRRRKRELEATLVYEVGKN-WVEASADVAEAIDFIEYY 145 Query: 75 IQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNS 134 + + + +E + PLG +VI WN+P + +VG +A GN+ Sbjct: 146 ARAALRYRYPAVEVVPYPGEDNESF--YVPLGAGVVIAPWNFPVAIFTGMIVGPVAVGNT 203 Query: 135 VVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER--FDHILYTGSTG 191 V+ KP+E + + + + I + + + G E L E I +TGS Sbjct: 204 VIAKPAEDAVVVGAKVFEIFHEAGFPPGVVNFLPGVGEEVGAYLVEHPRIRFINFTGSLE 263 Query: 192 VGKIIMTAAAKH------LTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCV 245 VG I AA + +E GGK VD+ D D+A + + GQ C Sbjct: 264 VGLKIYEAAGRLAPGQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCS 323 Query: 246 APDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIE-----G 300 A ++ ++E++ K + A+++ D G ++SA ++V+ IE G Sbjct: 324 AASRLILTQGAYEPVLERVLKRAERLSVGPAEENPDLGPVVSAEQERKVLSYIEIGKNEG 383 Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360 Q V G + +IAPT+ T+V P++ + QEEIFGPVL ++ V+ EA++ N Sbjct: 384 QLVLGGKRLEGEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVANDTPY 443 Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHG-KKSF 419 L ++S + ++ E G + N I + PFGG SG + G Sbjct: 444 GLTGGVYSRKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKTGALDYL 503 Query: 420 ETFSHRRSC 428 F ++ Sbjct: 504 RLFLEMKAV 512 >3ROS-A nrPDB Length = 484 Score = 396 bits (1017), Expect = e-110, Method: Composition-based stats. Identities = 104/450 (23%), Positives = 174/450 (38%), Gaps = 17/450 (3%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 +I EA+ A A + R R + L + ++E E EL + ++ K + E Sbjct: 27 QIDEAINLAHALYKKWRHEEPASRAEILHDIANALKEHEDELAKMMTLEMGKLLSES-KE 85 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 EV + Y PE + + Y + GV++ WN+P I Sbjct: 86 EVELCVSICNYYADHGPEMLKPTKLN----SDLGNAYYLKQSTGVIMACEPWNFPLYQVI 141 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIP-QYLDKD-LYPVINGGVPETTELLKER 180 + GN ++LK + A+L A II + L + + R Sbjct: 142 RVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPEGSLINLYPSYDQLADIIADPR 201 Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240 + TGS G + AA K+L T+ELGG V + D V + + N Sbjct: 202 IQGVALTGSERGGSAVAEAAGKNLKKSTMELGGNDAFIVLDDADPQVLRNVLNDARTYND 261 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFY-GEDAKKSRDYGRIISARHFQRVMGLIE 299 GQ C + I+ + S ++++ +LK G+ + + S + +++ ++ Sbjct: 262 GQVCTSSKRIIVEKSRYDEVLHELKNVFSNLKAGDPLEADTTLPPMNSEKAKEKLEAQVK 321 Query: 300 -----GQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQ 353 G KV Y D+ + PTILTD+ +PV +E+FGP+ + V AIQ Sbjct: 322 EAIDAGAKVFYQYPEIDSKGAFFRPTILTDIAKDNPVFDKEVFGPIAEVFVVEDDNAAIQ 381 Query: 354 FINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSY 413 N L + S+ KK+ A+ +G N IT LPFGG+ SG G Sbjct: 382 LANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVINGRW--ITSGELPFGGIKKSGYGRE 439 Query: 414 HGKKSFETFSHRRSCLVRPLMNDEGLKVRY 443 F + + N++ + + Sbjct: 440 LSGLGLMAFVNEHLV-IDVTKNNQAENLYF 468 >3VZ0-A nrPDB Length = 459 Score = 395 bits (1016), Expect = e-110, Method: Composition-based stats. Identities = 108/439 (24%), Positives = 187/439 (42%), Gaps = 17/439 (3%) Query: 2 SKISEAVKRARAAFSS-GRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 +++ + RA + + + R + R + + L++ Q +A ++ K +A Sbjct: 27 AQMKDITDRAEHVWKTDWKLRSIAQRKEIVSRAADLLRRDRQHHASLIATEMGKALPDAL 86 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 EE+ + + + E+ A P++ + + I ++PLG++ I WN+P+ Sbjct: 87 -EEIDVTADILSFYANGAEEFLAPTPLKV----KTGQAKIINQPLGIIYCIEPWNFPYYQ 141 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL-K 178 + + AGN V+ K + A + Y I ++ EL+ Sbjct: 142 LARVAGPNLMAGNVVIAKHAPNVPQCALAFEKLFHDAGAPVGAYANIFLDNDQSAELIKD 201 Query: 179 ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 ER + TGS G+ + A L T+ELGG V + DLD+A + WG+F Sbjct: 202 ERIRGVALTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVLDDADLDLAVKWAVWGRFA 261 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISAR----HFQR 293 N+GQ C A ++ + + ++ LK ++ F G + +G + S R + Sbjct: 262 NNGQVCTAAKRMIVHEKVYDAFLDGLKTAITRFRIGNPLDRDTTHGPMSSLRAMELALDQ 321 Query: 294 VMGLIE-GQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351 ++ G + GG D ++ PTILTDV +PV +EIFGPV + V S + A Sbjct: 322 TAEAVKGGATLVAGGKRMDRKGFFMEPTILTDVSKDNPVFYQEIFGPVAVVHKVASEQAA 381 Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411 I N L +FS + +K+ + +G V N LPFGG+ NSG G Sbjct: 382 IDLANDSPYGLGGAVFSRDIARAEKVAEQVETGMVFINTAT--AAAPELPFGGIKNSGFG 439 Query: 412 SYHGKKSFETFSHRRSCLV 430 E F +R+ + Sbjct: 440 RELSFLGIEEFINRKLVRI 458 >5KF0-A nrPDB Length = 485 Score = 394 bits (1014), Expect = e-110, Method: Composition-based stats. Identities = 113/434 (26%), Positives = 190/434 (43%), Gaps = 17/434 (3%) Query: 10 RARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLE 69 A A R P R L+ +E+ EL AL + K ++ EV +++ Sbjct: 57 AAVDAVKPMRELPAYRRQAVLDHCVARFRERFDELAEALCIEAGKPINDSR-GEVTRLID 115 Query: 70 EIEYMIQKLPEWAADEP-VEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGA 128 ++ + +E + + Q Y P+G I +N+P NL + A Sbjct: 116 TFRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPA 175 Query: 129 IAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTEL-LKERFDHILY 186 +AAG VLKP+ + A ++A ++ + L K + V+ ERF + + Sbjct: 176 LAAGCPFVLKPASRTPVGALIIAEVLAETNLPKGAFSVLPAHRDGADLFTTDERFRLLSF 235 Query: 187 TGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNC--DLDVACRRIAWGKFMNSGQTC 244 TGS VG + A K V LELGG + VD + LD R+A+G + SGQ+C Sbjct: 236 TGSPAVGWALKEKAGK--KKVVLELGGNAAAIVDADQFEQLDYVVDRLAFGAYYQSGQSC 293 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE---- 299 + IL S+ + + +KL + G+ S G +IS +R+ G ++ Sbjct: 294 IGVQRILVHASLYDTLRDKLVAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVA 353 Query: 300 -GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQR 358 G K+ GG D A T+L DV + + ++E FGPV + ++A+ +N Sbjct: 354 AGAKIIAGGKVDGAM--FEATLLEDVGREQDLYRKEAFGPVAILEKFDRFDDALARVNDS 411 Query: 359 EKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKS 418 + L +F+ + ++ E GGV NDV + ++P+GGV +SG+G + + Sbjct: 412 DFGLQAGVFTDSLTHAQRAWDELEVGGVVINDVP-SFRVDNMPYGGVKDSGLGREGIRYA 470 Query: 419 FETFSHRRSCLVRP 432 E + R +VR Sbjct: 471 IEDMTEPRLMVVRR 484 >5VBF-A nrPDB Length = 478 Score = 394 bits (1012), Expect = e-110, Method: Composition-based stats. Identities = 110/437 (25%), Positives = 191/437 (43%), Gaps = 16/437 (3%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 I AV+ A AF + R R L L +E+ + + + D K Sbjct: 45 DIDAAVQAAHRAFVTWRHESPLVRSDLLRRAAALARERAETIGRHITMDQGKPL-REAIA 103 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 EVV E++E+ ++ ++P Q + EP+GV WN+PF+ + Sbjct: 104 EVVSAAEQLEWHAEEGRRTYGRVVPARSPDVMQT---VLREPIGVCAAFSPWNFPFSQAM 160 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE-- 179 + A+A+G ++VLK E S + LA + L ++ G + ++ L E Sbjct: 161 HKIAAALASGCTLVLKGPEESPSAIVALAQLFHDAGLPPGCLNIVWGVPGDVSKQLIEAP 220 Query: 180 RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239 + I +TGS VGK + AA + +T+ELGG +P V + D++ A +A KF N Sbjct: 221 QVRKISFTGSVPVGKQLAALAASLMKRMTMELGGHAPVLVCADADVERAAAMLAAYKFRN 280 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298 +GQ CV+P + ++ V ++ G G + AR + + Sbjct: 281 AGQVCVSPTRFFVQRAAFDRFVCAYLDAVGTIRVGYGLDAGVTMGPLAHARRVDEIDAFV 340 Query: 299 -----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAI 352 +G ++A GG Y APT++ + +M +E FGP++ IV L++A+ Sbjct: 341 ADATAKGAQIATGGMRLPGPGHYFAPTVVLGPTRDTRLMNDEPFGPIVGIVPFDDLDDAL 400 Query: 353 QFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGS 412 N+ LA Y F+++ + ++ +G V N + +PFGGV +SG GS Sbjct: 401 AEANRLPFGLASYAFTTSARNAHRISRALEAGMVNINHF--GMGPAEIPFGGVKDSGFGS 458 Query: 413 YHGKKSFETFSHRRSCL 429 G ++F+ + + Sbjct: 459 EGGMEAFDGYLVTKFVT 475 >3RH9-A nrPDB Length = 506 Score = 393 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 107/439 (24%), Positives = 195/439 (44%), Gaps = 19/439 (4%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + AV+ ++A P++ R + LE ++ ++E +E+ L + K W Sbjct: 49 EDVVAAVEAGQSALRLTNPWPIETRRKWLEDIRDGLKENREEIGRILCMEHGKP-WKEAQ 107 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELY-IHSEPLGVVLVIGTWNYPFNL 120 EV Y +Y + + + P+ +D + +H P+GV +I WN+P + Sbjct: 108 GEVDYAAGFFDYCAKHISALDS----HTIPEKPKDCTWTVHYRPVGVTGLIVPWNFPIGM 163 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179 + + A+AAG V+KP+ + +++ + L + ++ G ++L E Sbjct: 164 IAKKLSAALAAGCPSVIKPASETPLTMIAFFSVMDKLDLPDGMVNLVMGKASVIGKVLCE 223 Query: 180 R--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKF 237 + +TGST VG+ ++ A+ + + LELGG +P V + DL+ A + KF Sbjct: 224 HKDVPMLSFTGSTEVGRKLIVDTAEQVKKLALELGGNAPFIVFDDADLEAAADNLIANKF 283 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVM- 295 GQTCV + I + + +KL + + + G+ D G +I+ + F +V Sbjct: 284 RGGGQTCVCANRIFVHEKVADAFGQKLAERVNKMTVGDGMNDGIDIGPLINKQGFDKVKR 343 Query: 296 ----GLIEGQKVAYGGTG--DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 L +G + G + PT++ VD + QEE FGP++P+ R+ E Sbjct: 344 HLQDALDKGASLVAGKQPAELGDGLFFPPTVVQGVDREMCCYQEETFGPLVPMALFRTEE 403 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 E I N E LA Y+F+++ + +++ A G V N PFGG+ SG Sbjct: 404 EVIDAGNDTEFGLASYVFTADAERAQRVAAGLRFGHVGWNTGT--GPTPEAPFGGMKASG 461 Query: 410 MGSYHGKKSFETFSHRRSC 428 +G G + F ++ Sbjct: 462 IGREGGLEGLFEFVEAQTV 480 >4X0T-A nrPDB Length = 513 Score = 393 bits (1010), Expect = e-110, Method: Composition-based stats. Identities = 95/446 (21%), Positives = 187/446 (41%), Gaps = 20/446 (4%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 ++ E VK+AR A+ P R + + + ++E+ Q L ++ ++ K Sbjct: 59 VADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEG- 117 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHS-EPLGVVLVIGTWNYPFN 119 EV ++ +Y + P + I P+G+V +I +N+P Sbjct: 118 VGEVQEYVDICDYAVGLSRMIGGPIL----PSERSGHALIEQWNPVGLVGIITAFNFPVA 173 Query: 120 LTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPETT 174 + A+ GN + K + + ++ + II + L+ + P + GG T Sbjct: 174 VYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGT 233 Query: 175 ELL-KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 + ER + + +TGST VGK + + LELGG + ++ DL + Sbjct: 234 AMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSAL 293 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQ 292 + +GQ C + SI +++V +LKK+ + G + YG + + + Sbjct: 294 FAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVS 353 Query: 293 RVMGLI-----EGQKVAYGGT-GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346 +G + EG V YGG D Y+ PTI+T + + + E F P+L + + Sbjct: 354 MFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFK 413 Query: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKK-MIAETSSGGVAANDVIVHITLHSLPFGGV 405 + EE + N+ ++ L+ +F+ + I + + + S G+ ++ FGG Sbjct: 414 NEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGE 473 Query: 406 GNSGMGSYHGKKSFETFSHRRSCLVR 431 ++G G G +++ + R +C + Sbjct: 474 KHTGGGRESGSDAWKQYMRRSTCTIN 499 >3EFV-A nrPDB Length = 462 Score = 393 bits (1010), Expect = e-110, Method: Composition-based stats. Identities = 105/436 (24%), Positives = 179/436 (41%), Gaps = 16/436 (3%) Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62 +I A+ A + F + + R Q L + + ++ +E+ + ++ K A Sbjct: 30 EIEHALSLAASGFKKWKMTSVAQRAQTLRDIGQALRAHAEEMAQCITREMGKPIKQAR-A 88 Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122 EV ++ + P EP + + I PLGV+L I WN+P + Sbjct: 89 EVTKSAALCDWYAEHGPAMLNPEPT----LVENQQAVIEYRPLGVILAIMPWNFPLWQVL 144 Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE-R 180 + V + AGNS +LK + A ++A I+ + +Y +N ++++ + R Sbjct: 145 RGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVYGWVNANNEGVSQMINDPR 204 Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240 + TGS G I A L LELGG P V + DL++A + G++ N+ Sbjct: 205 IAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLELAVKAAVAGRYQNT 264 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRII-----SARHFQRV 294 GQ C A + + I ++ + G+ + D G + H Q Sbjct: 265 GQVCAAAKRFIVEEGIAQAFTDRFVAAAAALKMGDPLVEENDLGPMARFDLRDELHQQVQ 324 Query: 295 MGLIEGQKVAYGGTGDAA-TRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQ 353 + EG ++ GG A Y A T+L DV P ++E+FGPV I + A+ Sbjct: 325 ASVAEGARLLLGGEKIAGEGNYYAATVLADVTPDMTAFRQELFGPVAAITVAKDAAHALA 384 Query: 354 FINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSY 413 N E L+ +F+++D + +M A GGV N + + FGGV SG G Sbjct: 385 LANDSEFGLSATIFTADDTLAAEMAARLECGGVFING--YSASDARVAFGGVKKSGFGRE 442 Query: 414 HGKKSFETFSHRRSCL 429 F + ++ Sbjct: 443 LSHFGLHEFCNVQTVW 458 >5N5S-A nrPDB Length = 515 Score = 391 bits (1006), Expect = e-109, Method: Composition-based stats. Identities = 97/420 (23%), Positives = 186/420 (44%), Gaps = 17/420 (4%) Query: 25 FRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAAD 84 R LE + ++ + +E+ L + K +A EV ++ + ++ + Sbjct: 99 ERKAVLEKVVAELKNRFEEIAQTLTMESGKPIKDAR-GEVTRTIDTFQVAAEESVRIYGE 157 Query: 85 E-PVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELS 143 P++ + + + + + P+G V ++ WN+P NL + AIA G VLKP+ + Sbjct: 158 HIPLDISARNKGLQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASRT 217 Query: 144 ENMASLLATIIP--QYLDKDLYPVINGGVPETTEL-LKERFDHILYTGSTGVGKIIMTAA 200 A +L I+ + L + ++ + + ERF + +TGS +G + A Sbjct: 218 PLSALILGEILHKIEELPLGAFSILPVSREDADMFTVDERFKLLTFTGSGPIGWDMKARA 277 Query: 201 AKHLTPVTLELGGKSPCYVDKNC-DLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ 259 K V +ELGG +PC VD DLD +R+ G F GQ+C+ + + ++ Sbjct: 278 GK--KKVVMELGGNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDE 335 Query: 260 IVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE-----GQKVAYGGTGDAAT 313 + E ++K+ G ++ G +IS + + ++ G K+ GG + Sbjct: 336 VKEGFVAAVKKLKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGKLLTGG--NRKG 393 Query: 314 RYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKV 373 +I PT++ DV ++ +EEIFGPV+ + +EA++ N L +F+ + Sbjct: 394 AFIEPTVIEDVPIEANARKEEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGIFTKDLNK 453 Query: 374 IKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPL 433 GGV ND + + S P+GG+ +SG+ K + + + ++R + Sbjct: 454 AFYAFEHMEVGGVILNDSPA-LRVDSQPYGGLKDSGIQREGVKYAMDDMLETKVLVMRNV 512 >5JRY-A nrPDB Length = 485 Score = 388 bits (998), Expect = e-108, Method: Composition-based stats. Identities = 111/434 (25%), Positives = 186/434 (42%), Gaps = 17/434 (3%) Query: 10 RARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLE 69 A A R P R L+ +E+ EL AL + K N EV +++ Sbjct: 57 AAVDATKPMRELPAYKRQAVLDHCVARFRERFDELAEALCIEAGKPI-NDAKGEVTRLID 115 Query: 70 EIEYMIQKLPEWAADEP-VEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGA 128 ++ + +E + + Q Y P+G I +N+P NL + A Sbjct: 116 TFRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPA 175 Query: 129 IAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTEL-LKERFDHILY 186 +AAG VLKP+ + A ++ ++ + L K + V+ +RF + + Sbjct: 176 LAAGCPFVLKPASRTPVGALIIGEVLAETDLPKGAFSVLPAHRDGADLFTTDDRFRLLSF 235 Query: 187 TGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNC--DLDVACRRIAWGKFMNSGQTC 244 TGS VG + A K V LELGG + VD + LD R+A+G F SGQ+C Sbjct: 236 TGSPAVGWALKEKAGK--KKVVLELGGNAAAIVDADQLDRLDYVVDRLAFGAFYQSGQSC 293 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE---- 299 + IL I + + +KL + G+ S G +IS +R+ G ++ Sbjct: 294 IGVQRILAHADIYDALRDKLIAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVA 353 Query: 300 -GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQR 358 G K+ GG D A T+L +V + ++E FGP+ + ++A+ +N Sbjct: 354 AGAKIVAGGKVDGAM--FEATLLENVGRDQDLYRKEAFGPIAILEKFDRFDDALARVNDS 411 Query: 359 EKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKS 418 + L +F+ + ++ E GGV NDV + ++P+GGV +SG+G + + Sbjct: 412 DFGLQAGVFTDSLAHTQQAWDELEVGGVVINDVP-SFRVDNMPYGGVKDSGLGREGIRYA 470 Query: 419 FETFSHRRSCLVRP 432 E + R +VR Sbjct: 471 IEDMTEPRLLVVRR 484 >3R64-A nrPDB Length = 508 Score = 388 bits (997), Expect = e-108, Method: Composition-based stats. Identities = 106/444 (23%), Positives = 195/444 (43%), Gaps = 19/444 (4%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 ++ + A + A+ A + P R + L++E +E+V L + A Sbjct: 49 IADVDAAYEAAKKAQAEWAATPAAERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKA- 107 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 E+ + TP + ++ GVV VI WN+P NL Sbjct: 108 NLEITLAGNITKESASFPGRVHGRISPSNTPGKEN---RVYRVAKGVVGVISPWNFPLNL 164 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLL-ATIIPQY-LDKDLYPVINGGVPETTELLK 178 +I+ + A+A GN+VV+KP+ + ++ A I + + + + G E + Sbjct: 165 SIRSVAPALAVGNAVVIKPASDTPVTGGVIPARIFEEAGVPAGVISTVAGAGSEIGDHFV 224 Query: 179 ER--FDHILYTGSTGVGKIIMTAA--AKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 I +TGST VG+ + A + V LELGG +P V + D+D A + A Sbjct: 225 THAVPKLISFTGSTPVGRRVGELAINGGPMKTVALELGGNAPFVVLADADIDAAAQAAAV 284 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293 G F++ GQ C++ + ++ D ++ ++ +EK +++K G+ + + G +I+ Sbjct: 285 GAFLHQGQICMSINRVIVDAAVHDEFLEKFVEAVKNIPTGDPSAEGTLVGPVINDSQLSG 344 Query: 294 VMGLIE-----GQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348 + IE G V G R + P + +DV + +EEIFGP++ ++ Sbjct: 345 LKEKIELAKKEGATVQV--EGPIEGRLVHPHVFSDVTSDMEIAREEIFGPLISVLKADDE 402 Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408 A + N + L+ ++S + + + SG V ND+ V+ H + FGG NS Sbjct: 403 AHAAELANASDFGLSAAVWSKDIDRAAQFALQIDSGMVHINDLTVNDEPHVM-FGGSKNS 461 Query: 409 GMGSYHGKKSFETFSHRRSCLVRP 432 G+G ++G + E F+ R ++ Sbjct: 462 GLGRFNGDWAIEEFTTDRWIGIKR 485 >5J6B-A nrPDB Length = 485 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 110/430 (25%), Positives = 185/430 (43%), Gaps = 17/430 (3%) Query: 14 AFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEY 73 A R P R LE +E+ EL AL + K ++ EV +++ Sbjct: 61 AQKPLRALPAFRRQAILEHCVARFRERFDELAQALCIEAGKPINDS-KGEVTRLIDTFRV 119 Query: 74 MIQKLPEWAADEP-VEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAG 132 ++ +E +P+ Q Y P+G I +N+P NL + A+AAG Sbjct: 120 AAEESVRIEGGLVNLEISPRAQGYSGYYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAG 179 Query: 133 NSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL-KERFDHILYTGST 190 VLKP+ + A ++ ++ + L K + ++ ERF + +TGS Sbjct: 180 CPFVLKPASRTPIGALIIGEVLAETDLPKGAFSILPAHRDGADLFTTDERFKLLSFTGSP 239 Query: 191 GVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCD--LDVACRRIAWGKFMNSGQTCVAPD 248 VG + A K V LELGG + VD + LD R+A+G + SGQ+C+ Sbjct: 240 TVGWELKKKAGKKK--VVLELGGNAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQ 297 Query: 249 YILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIE-----GQK 302 I+ + + + EKL + G+ + G +IS +R+ G +E G K Sbjct: 298 RIIAHADVYDALREKLIAKTRSLKMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAK 357 Query: 303 VAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPL 362 + GG D A T+L V + ++E FGPV + ++A+ +N + L Sbjct: 358 IVAGGKVDGAM--FEATLLEGVGRDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGL 415 Query: 363 ALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETF 422 +F+ + ++ E GGV NDV + ++P+GGV +SG+G + + E Sbjct: 416 QAGVFTDSLSHAQRAWDELEVGGVVINDVP-SFRVDNMPYGGVKDSGLGREGIRYAIEDM 474 Query: 423 SHRRSCLVRP 432 + R +VR Sbjct: 475 TELRLMVVRR 484 >4PXN-A nrPDB Length = 525 Score = 376 bits (967), Expect = e-105, Method: Composition-based stats. Identities = 94/445 (21%), Positives = 192/445 (43%), Gaps = 19/445 (4%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + E ++ A + P R + + + ++ + L ++ ++ K Sbjct: 72 VHDYEEGMRACFDAAKTWMAIPAPKRGEIVRQIGDALRAKLHHLGRLVSLEMGKILPEG- 130 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 EV +++ +Y + + + P E++ PLGVV VI +N+P + Sbjct: 131 IGEVQEIIDMCDYAVGLSRQLNGSIIPSERPNHMMMEVW---NPLGVVGVITAFNFPCAV 187 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP----VINGGVPETTEL 176 A+ GN VV K + + + + I+ L+K+ P G E + Sbjct: 188 LGWNACIALVCGNCVVWKGAPTTPLITIAMTKIVASVLEKNNLPGAIFTSFCGGTEIGQA 247 Query: 177 --LKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 L R + +TGST G ++ + LEL G + V + D+ +A R + + Sbjct: 248 IALDIRIPLVSFTGSTRAGLMVQQQVSARFGKCLLELSGNNAIIVMDDADIQLAVRSVLF 307 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293 +GQ C ++ +I +++L + K+ G+ +K G + + + Sbjct: 308 AAVGTAGQRCTTCRRLILHENIYQTFLDQLVEVYKQVRIGDPLEKGTLLGPLHTPASKEN 367 Query: 294 VMGLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 + I +G K+ +GG+ ++ ++ PTI+ ++ P +PV++EE+FGPVL ++ ++ Sbjct: 368 FLKGIQTIKSQGGKILFGGSAIESEGNFVQPTIV-EITPSAPVVKEELFGPVLYVMKFQT 426 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVI-KKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406 L+EAI+ N + L+ +F+ +I K + S G+ ++ + FGG Sbjct: 427 LKEAIEINNSVPQGLSSSIFTKRPDIIFKWLGPHGSDCGIVNVNIPTNGAEIGGAFGGEK 486 Query: 407 NSGMGSYHGKKSFETFSHRRSCLVR 431 +G G G S++ + R +C + Sbjct: 487 ATGGGREAGSDSWKQYMRRATCTIN 511 >4E4G-A nrPDB Length = 521 Score = 376 bits (965), Expect = e-104, Method: Composition-based stats. Identities = 98/433 (22%), Positives = 180/433 (41%), Gaps = 21/433 (4%) Query: 15 FSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYM 74 Q R + +L+ + EL L+ + K +A ++V LE E++ Sbjct: 77 QPKWAATNPQRRARVFMKFVQLLNDNMNELAEMLSREHGKTIDDA-KGDIVRGLEVCEFV 135 Query: 75 IQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNS 134 I +P E E ++Y +P+G+ I +N+P + + AIA GN+ Sbjct: 136 IG-IPHLQKSEFTE--GAGPGIDMYSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNA 192 Query: 135 VVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELLKE-RFDHILYTGSTGV 192 +LKPSE ++ LA + I L + V+NG +L + + GST + Sbjct: 193 FILKPSERDPSVPIRLAELMIEAGLPAGILNVVNGDKGAVDAILTHPDIAAVSFVGSTPI 252 Query: 193 GKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYIL- 251 + + AA + G K+ + + DLD A + + ++G+ C+A + Sbjct: 253 ARYVYGTAAMNGKRAQCFGGAKNHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVP 312 Query: 252 CDPSIQNQIVEKLKKSLKEFYGED-AKKSRDYGRIISARHFQRVMGLIE-----GQKVAY 305 N++++KL ++ + D G +++ QR+ LI+ G K+ Sbjct: 313 VGEETANRLIDKLVPMVESLRIGPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVV 372 Query: 306 GGT-----GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360 G G +I + DV P + + EIFGPVL +V R+ EEA+ + E Sbjct: 373 DGRDFKLQGYENGHFIGGCLFDDVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEY 432 Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGS--YHGKKS 418 + +++ + + + + G V N V + + L FGG +S G HG S Sbjct: 433 GNGVAIYTRDGDAARDFASRINIGMVGVN-VPIPVPLAYHSFGGWKSSSFGDLNQHGTDS 491 Query: 419 FETFSHRRSCLVR 431 + ++ ++ R Sbjct: 492 IKFWTRTKTITSR 504 >5U0M-A nrPDB Length = 497 Score = 372 bits (956), Expect = e-103, Method: Composition-based stats. Identities = 102/433 (23%), Positives = 184/433 (42%), Gaps = 22/433 (5%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + + AV+ AR AF + R + L R +EA L++ ++EL + + K W + Sbjct: 47 LEDVDAAVREARKAFLAWRRKSLAERQAVIEAFGELLEANKEELAHQIGLETGKPLWESR 106 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 EV ++ +I ++ E + P GVV V G +N+P +L Sbjct: 107 -TEVAAMMGKIPISVKAYNERTG----HTESDVAGGHAVLRHRPHGVVAVFGPYNFPGHL 161 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179 +V A+ AGN+VV KPSEL+ +A L + + L + ++ GG L + Sbjct: 162 PNGHIVPALLAGNTVVFKPSELTPGVAELTVRLWEKAGLPDGVINLVQGGSDTGKCLARH 221 Query: 180 R-FDHILYTGSTGVGKIIMTAAAKHLTPV-TLELGGKSPCYVDKNCDLDVACRRIAWGKF 237 D + +TGS+ VG ++ + LE+GG +P V DLD A F Sbjct: 222 SLIDGLFFTGSSTVGHLLHEQFGGQPEKILALEMGGNNPLIVQNVSDLDGAVHHALQSAF 281 Query: 238 MNSGQTCVAPDYILCDPSIQ-NQIVEKLKKSLKEFYGE--DAKKSRDYGRIISARHFQRV 294 +++GQ C +L + ++ + +L + DA G +ISA ++ Sbjct: 282 LSAGQRCTCARRLLVPKGKKGDEFLARLVEVAARITVAEFDADPQPFMGSVISAEAANQL 341 Query: 295 MGLIEGQKVAYGGTGDAATR-------YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 + + + G T + ++P I+ + + +E FGP+L + + Sbjct: 342 LKA-QAAMLEKGATSLLEMKQLKPDTGLLSPGIVDATGIE--LEDQEFFGPLLTVYRYKG 398 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 +EA++ N L+ + S + K+ +++ E +G V N + + PFGGVG Sbjct: 399 FDEALELANNTRYGLSAGILSDDRKLYNRLVEEVRAGIVNWNRPLTGASSA-APFGGVGA 457 Query: 408 SGMGSYHGKKSFE 420 SG + + Sbjct: 458 SGNHRPSAYYAAD 470 >6DBB-A nrPDB Length = 511 Score = 358 bits (919), Expect = 3e-99, Method: Composition-based stats. Identities = 90/453 (19%), Positives = 182/453 (40%), Gaps = 29/453 (6%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + + A AF RT P R + + +++E + EL + + K Sbjct: 50 ADAERKIDAAHDAFLKWRTVPAPVRGELVRVFGNVLREHKAELGRLVTLEAGKITSEGL- 108 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 EV +++ ++ + + + P + E + P+GV VI +N+P + Sbjct: 109 GEVQEMIDICDFAVGLSRQLYGLTIASERPGHRMMETW---HPIGVCGVISAFNFPVAVW 165 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLD------KDLYPVING----GVP 171 A G+SVV KPSE + A ++ + L + P G G+ Sbjct: 166 AWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKALREFEKTHPGVAPAELGQLVLGMR 225 Query: 172 ETTELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVAC 229 + E+L ++ + TGS +G+ + ++ L LELGG + V + DLD+ Sbjct: 226 DVGEVLTASKKVPVVSATGSVRMGQEVAKVLSQRLARGILELGGNNGMIVAPSADLDLVV 285 Query: 230 RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISA 288 R + + +GQ C ++ S+ Q++ +++K+ G ++ G ++ Sbjct: 286 RAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIEKAYASVKVGNPLEEGTLVGPLVDR 345 Query: 289 RHFQRVMGLIEGQK----VAYGGTGDAAT----RYIAPTILTDVDPQSPVMQEEIFGPVL 340 F + + + GG Y+ P I+ + QS V++ E F P+L Sbjct: 346 ASFDAMQKALADAREQGGEVKGGERVDVGHADAYYVRPAIVR-MPKQSAVVERETFAPIL 404 Query: 341 PIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKM--IAETSSGGVAANDVIVHITLH 398 ++ + ++AI N + L+ +F+++ + ++ A + G V N + Sbjct: 405 YVMVYDNFDDAIDVHNAVPQGLSSAIFTNDMREAEQFMSAAGSDCGIVNVN-IGTSGAEI 463 Query: 399 SLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431 FGG +G G G +++ + R + + Sbjct: 464 GGAFGGEKETGGGRESGSDAWKAYMRRATNTIN 496 >3JU8-A nrPDB Length = 490 Score = 358 bits (918), Expect = 5e-99, Method: Composition-based stats. Identities = 110/423 (26%), Positives = 184/423 (43%), Gaps = 19/423 (4%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 +++ AV AR AF + RPL+ RI+ LE ++ + EL + + K W + Sbjct: 42 TQVDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESA- 100 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 EV ++ ++ +Q E ++ T + +P GVV V G +N+P +L Sbjct: 101 TEVTSMVNKVAISVQAFRERTGEKSGPLADAT----AVLRHKPHGVVAVFGPYNFPGHLP 156 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASL-LATIIPQYLDKDLYPVINGGVPETTELLKER 180 +V A+ AGN VV KPSEL+ +A L L I L + ++ GG L R Sbjct: 157 NGHIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQGGRETGVALAAHR 216 Query: 181 -FDHILYTGSTGVGKIIMTAAAKHLTPV-TLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 D + +TGS+ G ++ + + LE+GG +P V++ DLD A I F+ Sbjct: 217 GLDGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFI 276 Query: 239 NSGQTCVAPDYILCDPSIQ-NQIVEKLKKSLKEFYGE--DAKKSRDYGRIISARHFQRVM 295 ++GQ C +L + ++ +L D + + G +IS + ++ Sbjct: 277 SAGQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRFDEQPAPFMGAVISLSAAEHLL 336 Query: 296 GLIE-----GQKVAYGGTGD-AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 E G + T + P IL DV + EE FGP+L ++ Sbjct: 337 KAQEHLIGKGAQPLLAMTQPIDGAALLTPGIL-DVSAVAERPDEEFFGPLLQVIRYSDFA 395 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409 AI+ N + LA + S + + ++ + E+ +G V N + S PFGG+G SG Sbjct: 396 AAIREANATQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTGAA-SSAPFGGIGASG 454 Query: 410 MGS 412 Sbjct: 455 NHR 457 >4KNA-A nrPDB Length = 495 Score = 356 bits (915), Expect = 8e-99, Method: Composition-based stats. Identities = 107/425 (25%), Positives = 170/425 (40%), Gaps = 23/425 (5%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 + AV AR AF++ L R ++ L+ E+++ L + + K W A Sbjct: 46 DDVERAVASARRAFAAWSALDLDARCTIVKRFAALLVERKEALATMIGRETGKPLWEART 105 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 EV + +++ I E EK + P GVV V G +N+P +L Sbjct: 106 -EVASMAAKVDISITAYHERTG----EKRAPMADGVAVLRHRPHGVVAVFGPYNFPGHLP 160 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKER 180 +V A+ AGN+VV KPSEL+ +A I L + ++ G L R Sbjct: 161 NGHIVPALIAGNTVVFKPSELAPGVARATVEIWRDAGLPAGVLNLVQGEKDTGVALANHR 220 Query: 181 -FDHILYTGSTGVGKIIMTAAAKHLTPV-TLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238 D + +TGS+ G ++ V LE+GG +P V + D+D A F+ Sbjct: 221 QIDGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVVAEVEDIDAAVHHAIQSAFL 280 Query: 239 NSGQTCVAPDYILCDPSIQ-NQIVEKLKKSLKEFYGE--DAKKSRDYGRIISARHFQRVM 295 ++GQ C IL ++ V +L + DA G +ISAR R++ Sbjct: 281 SAGQRCTCARRILVPRGAFGDRFVARLADVASKITASVFDADPQPFMGAVISARAASRLV 340 Query: 296 GLIEGQKVAYGG--------TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 ++ G D A ++ IL DV + EE FGP+ IV Sbjct: 341 AA--QARLVGLGASPIIEMKQRDPALGFVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTD 397 Query: 348 LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN 407 L++AI N L+ + + +++ +G V N + + PFGG G Sbjct: 398 LDDAIARANDTAFGLSAGLLADDEQAWHTFRRAIRAGIVNWNR-PTNGASSAAPFGGAGR 456 Query: 408 SGMGS 412 SG Sbjct: 457 SGNHR 461 >4LGZ-A nrPDB Length = 563 Score = 353 bits (906), Expect = 1e-97, Method: Composition-based stats. Identities = 92/439 (20%), Positives = 172/439 (39%), Gaps = 30/439 (6%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQ-EQEQELVGALAADLHKNEWNAY 60 + ++ A+ A AA +P+ R Q ++ + E++ K A Sbjct: 100 ALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAE 159 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 + +++ + + E ++P+ P T ++ G V I +N+ Sbjct: 160 IDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHT---VYRGLEGFVAAISPFNFTA-- 214 Query: 121 TIQPMVGAIA-AGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL- 177 + GA A GN V+ KPS+ + + + I+ + L ++ + P + + Sbjct: 215 IGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVT 274 Query: 178 -KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDLDVACR 230 E I +TGS K + A++L + E GGK+ +V + D+D Sbjct: 275 SSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVS 334 Query: 231 RIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKK-SRDYGRIISA 288 F GQ C A + S+ QI +L + G+ A+ + +I A Sbjct: 335 GTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDA 394 Query: 289 RHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLP 341 + F R+ +E + +A G ++ Y+ P I+ DPQ P+M+EEIFGPVL Sbjct: 395 KAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLT 454 Query: 342 IVCVRSLE--EAIQFINQ-REKPLALYMFSSNDKVIKKMIAETS--SGGVAANDVIVHIT 396 + + E ++ ++ L +F+ + ++++ +G ND Sbjct: 455 VYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSV 514 Query: 397 LHSLPFGGVGNSGMGSYHG 415 + PFGG SG G Sbjct: 515 VGQQPFGGARASGTNDKPG 533 >1UXV-A nrPDB Length = 501 Score = 352 bits (905), Expect = 1e-97, Method: Composition-based stats. Identities = 110/431 (25%), Positives = 186/431 (43%), Gaps = 21/431 (4%) Query: 15 FSSGRT----RPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEE 70 F GR P R+ L +I+ L + K +A EV ++ Sbjct: 64 FKRGRWSARDMPGTERLAVLRKAADIIERNLDVFAEVLVMNAGKP-KSAAVGEVKAAVDR 122 Query: 71 IEYMIQKLPEWAAD-EPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAI 129 + L + D P + T T + E + EPLGVV I +NYP + + + Sbjct: 123 LRLAELDLKKIGGDYIPGDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSF 182 Query: 130 AAGNSVVLKPSELSENMASLLAT-IIPQYLDKDLYPVINGGVPETTELL-KERFDHILYT 187 GN+VV+KPS A++ ++ D ++N E +++ +R + +T Sbjct: 183 IYGNAVVVKPSISDPLPAAMAVKALLDAGFPPDAIALLNLPGKEAEKIVADDRVAAVSFT 242 Query: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247 GST VG+ ++ + +ELGG P V ++ DLD+A +IA G + +GQ C A Sbjct: 243 GSTEVGERVVKVGG--VKQYVMELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAI 300 Query: 248 DYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYG 306 +L + + ++VE++ K L G+ + D G +IS +M IE V G Sbjct: 301 KLVLAERPVYGKLVEEVAKRLSSLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDA-VEKG 359 Query: 307 GTGDAATR-----YIAPTIL---TDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQR 358 G A R Y+ PT++ D + + E+F PV V V+ L++AI+ N R Sbjct: 360 GRVLAGGRRLGPTYVQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGR 419 Query: 359 EKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKS 418 L +F + I++ + G + ND+ H + PFGG SG+ + Sbjct: 420 PYGLDAAVFGRDVVKIRRAVRLLEVGAIYINDMPRHG-IGYYPFGGRKKSGVFREGIGYA 478 Query: 419 FETFSHRRSCL 429 E + ++ + Sbjct: 479 VEAVTAYKTIV 489 >4H7N-A nrPDB Length = 474 Score = 352 bits (904), Expect = 2e-97, Method: Composition-based stats. Identities = 113/455 (24%), Positives = 210/455 (46%), Gaps = 33/455 (7%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 +++ RAR A S + ++ RI L+ ++ I + ++L AL D + Sbjct: 30 LAQQCNRARRAQSRWQELGVEGRITTLQQWKQAILSRREQLTEALVNDTGR--------- 80 Query: 64 VVYVLEEIEYMIQKLPEWAADEP-VEKTPQTQQDELYIHSE----PLGVVLVIGTWNYPF 118 + + EI+ + + W P + +T +I + P +V VI WN+P Sbjct: 81 LSITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFIALQQSLVPYPLVGVISPWNFPL 140 Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSE-NMASLLATIIPQYLDKDLYPVINGGVPETTELL 177 L++ + A+ AG +VV+KPSE++ +A LL + +D+ + GG ET L Sbjct: 141 TLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLMALNTVPELRDVLIFVEGGG-ETGANL 199 Query: 178 KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKF 237 D + +TGS G+ + AA+ P LELGGK P V ++ +L++A I WG Sbjct: 200 INYVDFVCFTGSVATGREVAETAARRFIPAYLELGGKDPAIVLESANLELATSAILWGAV 259 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKL-KKSLKEFYGEDAKKSRDYGRIISARHF----Q 292 +N+GQ+C++ + I S + +L K+ + + G II+ + Sbjct: 260 VNTGQSCLSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVEDGAIGPIIAEKQAGIIND 319 Query: 293 RVMGLIE-GQKVAYGGTGD--AATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349 ++ +E G + GG + + PT++T+V+ VM EE FGP++P++ +E Sbjct: 320 HILDAVEKGAVIHCGGKVEELGGGWWCRPTVMTNVNHSMKVMTEETFGPIMPVMPFPDVE 379 Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGN-- 407 EA+ N L+ +F+ ++ K+ + ++G ++ ND + +H G N Sbjct: 380 EAVYLANDTIYGLSAAVFAGSEDEALKVARQLNAGAISINDAALTAMMHE----GEKNAF 435 Query: 408 --SGM-GSYHGKKSFETFSHRRSCLVRPLMNDEGL 439 SG+ GS G + F +++ L++ + Sbjct: 436 NFSGLGGSRVGAAGLKRFLRKQAFLIKTNSTSDPW 470 >3V9H-A nrPDB Length = 566 Score = 351 bits (902), Expect = 3e-97, Method: Composition-based stats. Identities = 95/439 (21%), Positives = 174/439 (39%), Gaps = 30/439 (6%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQ-EQEQELVGALAADLHKNEWNAY 60 S +++A++ A AA +P+ R Q ++ + E++ K A Sbjct: 103 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 162 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 + +++ + + E +P+ P T ++ G V I +N+ Sbjct: 163 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAISPFNFTA-- 217 Query: 121 TIQPMVGAIA-AGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL- 177 + GA A GN V+ KPS+ + + + I+ + L ++ + P + + Sbjct: 218 IGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVT 277 Query: 178 -KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDLDVACR 230 E I +TGS K + A++L + E GGK+ +V ++ D++ Sbjct: 278 SSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVS 337 Query: 231 RIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKK-SRDYGRIISA 288 F GQ C A + S+ QI +L + G+ A+ + +I A Sbjct: 338 GTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDA 397 Query: 289 RHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLP 341 + F R+ +E + +A G D+ ++ P I+ DPQ P+M+EEIFGPVL Sbjct: 398 KSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLS 457 Query: 342 IVCVRSL--EEAIQFINQ-REKPLALYMFSSNDKVIKKMIAETS--SGGVAANDVIVHIT 396 + +E +Q ++ L +FS + V+++ +G ND Sbjct: 458 VYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSI 517 Query: 397 LHSLPFGGVGNSGMGSYHG 415 + PFGG SG G Sbjct: 518 VGQQPFGGARASGTNDKPG 536 >4I3V-A nrPDB Length = 488 Score = 351 bits (900), Expect = 5e-97, Method: Composition-based stats. Identities = 111/418 (26%), Positives = 192/418 (45%), Gaps = 21/418 (5%) Query: 25 FRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAAD 84 R + L A + +++E+ + +L ++ ++ Y EV + Q + Sbjct: 71 ERQKILLATAEALAARKEEISDVITLELGISKADSLY-EVGRAFDVFTLAGQMCIRDDGE 129 Query: 85 EPV-EKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELS 143 + TP + +++ EPL + I +N+P N+ + AIA N VV+KP+EL+ Sbjct: 130 IFSCDLTPHGKARKIFTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKPTELT 189 Query: 144 ENMASLLATIIPQY-LDKDLYPVINGGVPETT--ELLKERFDHILYTGSTGVGKIIMTAA 200 A LLA I+ + L ++ V+ G + + D + +TGS VGK+I A Sbjct: 190 PMTALLLADILYEAGLPPEMLSVVTGWPADIGMEMITNPHVDLVTFTGSVPVGKLIAANA 249 Query: 201 AKHLTPVTLELGGKSPCYVDK---NCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQ 257 H LELGG P + + DL A G NSGQ C A ILC S+ Sbjct: 250 --HYKRQVLELGGNDPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKRILCQESVA 307 Query: 258 NQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHF----QRVM-GLIEGQKVAYGGTGDA 311 ++ V + + K +G+ +S D G +I + +RVM EG + Y Sbjct: 308 DRFVPLVLERAKRLRFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGADILYHPGR-- 365 Query: 312 ATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA-IQFINQREKPLALYMFSSN 370 + + P ++ V QS ++ EE FGP++PIV V ++A I N L+ + +++ Sbjct: 366 SGALLPPIVVDRVPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAFGLSSGVCTND 425 Query: 371 DKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHG-KKSFETFSHRRS 427 + ++K IA G V +V + PFGG+ +SG G G ++ ++F++ ++ Sbjct: 426 YRRMQKYIAGLKVGTVNIWEVP-GYRIEMSPFGGIKDSGNGYKEGVIEAMKSFTNVKT 482 >4OE4-A nrPDB Length = 580 Score = 318 bits (815), Expect = 4e-87, Method: Composition-based stats. Identities = 97/433 (22%), Positives = 160/433 (36%), Gaps = 39/433 (9%) Query: 18 GRTRPLQFRIQQLEALQRLI-QEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQ 76 P R LI + +++ A KN + A + + + + Y ++ Sbjct: 115 WYNLPFYDRSAIFLKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVK 174 Query: 77 KLPEWAADEPVEKTPQTQQDELYIHSEPL-GVVLVIGTWNYPFNLTIQPMVGAIAAGNSV 135 + A +PVE T Y PL G V + +N+ A+ GN+V Sbjct: 175 YASDLYAQQPVESADGTWNKAEY---RPLEGFVYAVSPFNFTAIAANLIGAPAL-MGNTV 230 Query: 136 VLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTE--LLKERFDHILYTGSTGV 192 V KPS+ + LL T++ + L K + I G + T+ L + F + +TGST V Sbjct: 231 VWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNV 290 Query: 193 GKIIM--------TAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTC 244 K + + + E GGK+ V + ++ A G F GQ C Sbjct: 291 FKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKC 350 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSR----------DYGRIISARHFQRV 294 A + S + + + L+ S G +I + F ++ Sbjct: 351 SAASRLYLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKL 410 Query: 295 MGLIEGQK------VAYGGTGDAA-TRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347 + +IE K + YGG D + ++ PT++ P P M E FGP+L + Sbjct: 411 VKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPD 470 Query: 348 LE--EAIQFI-NQREKPLALYMFSSNDKVIKKMIAET--SSGGVAANDVIVHITLHSLPF 402 E E I N + L +F+ + K I+ + S+G ND + F Sbjct: 471 TEFNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWF 530 Query: 403 GGVGNSGMGSYHG 415 GG SG G Sbjct: 531 GGARMSGTDDKAG 543 >4IDS-A nrPDB Length = 563 Score = 277 bits (708), Expect = 9e-75, Method: Composition-based stats. Identities = 88/436 (20%), Positives = 151/436 (34%), Gaps = 30/436 (6%) Query: 18 GRTRPLQFRIQQLEALQRLI-QEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQ 76 P R L+ +++ A K+ + A + V +++ + + Sbjct: 115 WAALPFDERAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFWRFNVA 174 Query: 77 KLPEWAADEPVEKTPQTQQDELYIHSEPL-GVVLVIGTWNYPFNLTIQPMVGAIAAGNSV 135 + +P+ + I PL G V I +N+ P A+ GN+V Sbjct: 175 FARQILEQQPI----SGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPAL-MGNTV 229 Query: 136 VLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETT--ELLKERFDHILYTGSTGV 192 + KPS A L ++ L + ++ G + L R I +TGST Sbjct: 230 IWKPSITQTLAAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTAT 289 Query: 193 GKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVA 246 + ++ + E GGK + DV + G F GQ C A Sbjct: 290 FGHLWQWVGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSA 349 Query: 247 PDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLIEGQK--- 302 S+ ++ ++L E YG+ S G +I R F + + IE K Sbjct: 350 VSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAA 409 Query: 303 ---VAYGGTGDAA-TRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL--EEAIQFIN 356 VA GG D + ++ PT+L DP E FGP+L + E+ + I+ Sbjct: 410 AVTVAVGGEYDDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDVID 469 Query: 357 Q-REKPLALYMFSSNDKVIKKMIAETS--SGGVAANDVIVHITLHSLPFGGVGNSGMGSY 413 L + + + + + + +G ND + PFGG S Sbjct: 470 TGSRYALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSDTNDK 529 Query: 414 HG-KKSFETFSHRRSC 428 G + ++ RS Sbjct: 530 AGSPLNLLRWTSARSI 545 >5DBV-A nrPDB Length = 445 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 75/445 (16%), Positives = 164/445 (36%), Gaps = 38/445 (8%) Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 +++A++ A+ A + + R + + A+++ E + L + Sbjct: 16 DDMNQAIEAAKEAQLVVKKMSMDQREKIISAIRKKTIEHAETLARMAVEETG-------M 68 Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLT 121 V + + + + + +K P ++ + + P GV+ I P Sbjct: 69 GNVGHKILKHQLVAEKTPG--TEDITTTAWSGDRGLTLVEMGPFGVIGAITPCTNPSETI 126 Query: 122 IQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPV-----INGGVPETTEL 176 I +G +A GN+VV P + ++ +I + PV + +++++ Sbjct: 127 ICNTIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASLSAGGPVNIACSVRKPTLDSSKI 186 Query: 177 LKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234 + D I TG GV ++ + G P VD+ D+ A I Sbjct: 187 MMSHQDIPLIAATGGPGVVTAVLQSG----KRGIGAGAGNPPVLVDETADIRKAAEDIIN 242 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRV 294 G ++ +A ++ +I N+++ + K + ++ + +I+ + R Sbjct: 243 GCTFDNNLPAIAEKEVVAIDAIANELMNYMVKEQGCYAITKEQQEKLTNLVITPKGLNRN 302 Query: 295 MGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQF 354 + + + G G I I+ + + + P++ EE+ P+L IV +S ++A++ Sbjct: 303 C-VGKDARTLLGMIGIDVPSNIR-CIIFEGEKEHPLISEELMMPILGIVRAKSFDDAVEK 360 Query: 355 INQREKP--LALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGS 412 E + ++ S N I + + N S G G G + Sbjct: 361 AVWLEHGNRHSAHIHSKNVDRITTYAKAIDTAILVKN-------APSYAAIGFGGEGFCT 413 Query: 413 Y-------HGKKSFETFSHRRSCLV 430 + G S TF+ RR C++ Sbjct: 414 FTIASRTGEGLTSASTFTKRRRCVM 438 >1O20-A nrPDB Length = 427 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 92/452 (20%), Positives = 173/452 (38%), Gaps = 69/452 (15%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 M ++ E K+ R A+ R + + + ++ + + E+ +E++ A D+ K Sbjct: 13 MDELLEKAKKVREAWDVLRNATTREKNKAIKKIAEKLDERRKEILEANRIDVEKARERGV 72 Query: 61 YEEVVYVL----EEIEYMIQKLPE-WAADEPVEKTPQTQQDELYIH----SEPLGVVLVI 111 E +V L + I+ MI+ +PV + + E + P+G + +I Sbjct: 73 KESLVDRLALNDKRIDEMIKACETVIGLKDPVGEVIDSWVREDGLRIARVRVPIGPIGII 132 Query: 112 GTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVP 171 + N+T++ + A+ +GN+++L+ + N + + I + L + P + Sbjct: 133 --YESRPNVTVETTILALKSGNTILLRGGSDALNSNKAIVSAIREALKETEIPESSVEFI 190 Query: 172 ETTEL--------LKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELG-GKSPCYVDKN 222 E T+ L+E ++ G G+ + A PV LE G G +VD++ Sbjct: 191 ENTDRSLVLEMIRLREYLSLVIPRGGYGLISFVRDNAT---VPV-LETGVGNCHIFVDES 246 Query: 223 CDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDY 282 DL A I K G TC A + +L I + + + + L+ Sbjct: 247 ADLKKAVPVIINAKTQRPG-TCNAAEKLLVHEKIAKEFLPVIVEELR------------- 292 Query: 283 GRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI 342 +H V G TR I P ++ + P E ++ I Sbjct: 293 ------KHGVEVRGC-------------EKTREIVPDVVPATEDDWP---TEYLDLIIAI 330 Query: 343 VCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPF 402 V++++EAI+ I + + + + N KK ++E + V N S F Sbjct: 331 KVVKNVDEAIEHIKKYSTGHSESILTENYSNAKKFVSEIDAAAVYVN--------ASTRF 382 Query: 403 GGVGNSGMGSYHGKKSFETFSHRRSCLVRPLM 434 G G G+ G S + F R +R L Sbjct: 383 TDGGQFGFGAEIGI-STQRFHARGPVGLRELT 413 >3V4C-A nrPDB Length = 528 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 84/464 (18%), Positives = 159/464 (34%), Gaps = 56/464 (12%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + ++ A + A AF + + R L A+ I+ + + + + + E Sbjct: 62 VELVNRACEAAEEAFWTYGYSSRKERAAFLRAIADEIEARAEAITEIGSQETGLPEAR-L 120 Query: 61 YEEVVYVLEEIEYMIQKLP-----EWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWN 115 E ++ + + D + + + E+ + P+G V V G N Sbjct: 121 NGERGRTTGQLRLFADHIEKGDYLDRRVDAAMPERQPAPRQEIRLVQRPVGPVAVFGASN 180 Query: 116 YPFNL--TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLD-----KDLYPVING 168 +P A+AAG VV+K ++A + + ++ +I G Sbjct: 181 FPLAFSTAGGDTAAALAAGCPVVVKGHSAHPGTGEIVAEAVDAAIRKTGVHPGVFSLIQG 240 Query: 169 GVPETTELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTL--ELGGKSPCYVDK--- 221 G + L + +TGS G+ + A P+ ELG +P ++ Sbjct: 241 GSRDVGHALVQHPHIKAVGFTGSLAGGRALFDLCAARPEPIPFFGELGSVNPMFLLPEAL 300 Query: 222 NCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSI-QNQI----VEKLKKSLKEFYGED- 275 + + A M +GQ C P + ++ VE L K + D Sbjct: 301 KARAETLGQGWAGSLTMGAGQFCTNPGIAVVIEGADADRFTTAAVEALAKVAPQTMLTDG 360 Query: 276 -AKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQ---SPVM 331 AK RD + R+ + + E ++ R +P + Q + Sbjct: 361 IAKAYRDGQARFATRNAVKPLLATE-----------SSGRDASPNLFETTGAQFLADHAL 409 Query: 332 QEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF--SSNDKVIKKM--IAETSSGGVA 387 EE+FGP+ +V V S E + + L + + + + +++ + E +G V Sbjct: 410 GEEVFGPLGLVVRVGSPAEMEELARGFQGQLTATIHMDAGDLETARRLRPVLERKAGRVL 469 Query: 388 ANDVIVHI-----TLHSLPFGGVGNSGMGSYHGKKSFETFSHRR 426 N + +H P+ N G S T S RR Sbjct: 470 VNGFPTGVEVVDSMVHGGPYPASTN------FGATSVGTMSIRR 507 >5JFN-A nrPDB Length = 524 Score = 203 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 82/435 (18%), Positives = 164/435 (37%), Gaps = 45/435 (10%) Query: 22 PLQFRIQQLEALQR-LIQEQEQELVGALAADL-------HKNEWNAYYEEVVYVLEEIEY 73 + R + ++ ++ ++ + E + +A + HK N E +E++ Sbjct: 112 SMSDRARFVQGIRDVILNQDTLEKMSRMAVEETGMGNYEHKLIKNRLAGEKTPGIEDL-- 169 Query: 74 MIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGN 133 + P GV+ I P + +G +AAGN Sbjct: 170 -------------TTDAFSGDNGLTLVEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGN 216 Query: 134 SVVLKPSELSENMASLLATIIPQYL-----DKDLYPVINGGVPETTELLKER--FDHILY 186 SVV P + ++ LL +I Q L ++L + E T + ++ Sbjct: 217 SVVFSPHPRARQVSLLLVRLINQKLAALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVA 276 Query: 187 TGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVA 246 TG + K +++ G P VD+ +++ A I G ++ VA Sbjct: 277 TGGPAIVKAVLSTG----KKAIGAGAGNPPVVVDETANIEKAACDIVNGCSFDNNLPXVA 332 Query: 247 PDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYG 306 I+ I + ++ LKK+ + A + +++A+ + + + Sbjct: 333 EKEIIAVAQIADYLIFNLKKNGAYEIKDPAVLQQLQDLVLTAKGGPQTKCVGKSAVWLLS 392 Query: 307 GTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKP--LAL 364 G + I IL +V + P +QEE+ P+LP+V V ++++AI + E Sbjct: 393 QIGISVDASIK-IILMEVPREHPFVQEELMMPILPLVRVETVDDAIDLAIEVEHDNRHTA 451 Query: 365 YMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG----SYHGKKSFE 420 M S++ + + KM + + + + L + GG G S + G S + Sbjct: 452 IMHSTDVRKLTKMAKLIQT-TIFVKNGPSYAGLGA---GGEGYSTFTIAGPTGEGLTSAK 507 Query: 421 TFSHRRSCLVRPLMN 435 +F+ RR C++ +N Sbjct: 508 SFARRRKCVMVEALN 522 >5UJU-A nrPDB Length = 576 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 93/445 (20%), Positives = 155/445 (34%), Gaps = 47/445 (10%) Query: 5 SEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE-- 62 + A AA + R I + + E+ ++ + A+ Sbjct: 98 DALIAAAAAAQRTWREAGPSAWIGVSLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGG 157 Query: 63 --EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHS---EPLGVVLVIGTWNYP 117 LE + Y +L AD EK P G LV+G +P Sbjct: 158 PHAQDRALEAVAYAWDQLRRIPADAHWEKPQGKNPPLAMQKRYTIVPRGTGLVLGCCTFP 217 Query: 118 FNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLY--PVI-------NG 168 + +A GN+V++KP + ++ I L + + V+ N Sbjct: 218 TWNGYPGLFADLATGNTVIVKPHPGAILPLAITVRIARDVLREAGFDPNVVTLLATEPND 277 Query: 169 GVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVA 228 G L+ I +TGST G + A H V E G + +D DL A Sbjct: 278 GALVQDLALRPEIKLIDFTGSTQNGTWLERHA--HQAQVYTEKAGVNQIVIDSTDDLKAA 335 Query: 229 CRRIAWGKFMNSGQTCVAPDYILCDP---------SIQNQIVEKLKKSLKEFYGEDAKKS 279 + IA+ + SGQ C AP I + +++ + + ++++ G+ A+ Sbjct: 336 AKNIAFSLALYSGQMCTAPQNIYVPRDGIRTADGHASFDEVAQAIAGAVQKLTGDPARSV 395 Query: 280 RDYGRIIS---------ARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILT-DVDPQSP 329 G I + AR RV+ ++ Q + + DA R P +L DV + Sbjct: 396 ELIGAIQNDGVTARIDAARAVGRVL--LDSQTLQHPAFPDARVR--TPLVLQLDVADREK 451 Query: 330 VMQEEIFGPVLPIVCVRSLEEAIQFI---NQREKPLALYMFSSNDKVIKKMIAETSSGGV 386 Q E FGP+ ++ S +++ L L ++S+ D VI GGV Sbjct: 452 FTQ-EWFGPISFVIATDSTAQSLDLAGEIAAEHGALTLSVYSTADDVIDAAHEAAVRGGV 510 Query: 387 A--ANDVIVHITLHSLPFGGVGNSG 409 A N S F +G Sbjct: 511 ALSINLTGGVFVNQSAAFSDFHGTG 535 >1EZ0-A nrPDB Length = 510 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 64/438 (14%), Positives = 145/438 (33%), Gaps = 41/438 (9%) Query: 19 RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKL 78 R R L + ++ + +++ + E+ ++ + Sbjct: 47 RRLNNSKRASLLRTIASELEARSDDIIARAHLET-ALPEVRLTGEIARTANQLRLFADVV 105 Query: 79 PEWAADEPVEKTPQT-----QQDELYIHSEPLGVVLVIGTWNYPFNLTI--QPMVGAIAA 131 + + + TP + ++ LG V V G N+P + A+AA Sbjct: 106 NSGSYHQAILDTPNPTRAPLPKPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALAA 165 Query: 132 GNSVVLKPSELSENMASLLATIIPQY-----LDKDLYPVINGGVPETTELLKER--FDHI 184 G V++K + ++A I Q L + ++ ++ G + L + Sbjct: 166 GCPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTLLQGNQRALGQALVSHPEIKAV 225 Query: 185 LYTGSTGVGKIIMTAAAKHLTPV--TLELGGKSPCYVDKN-----CDLDVACRRIAWGKF 237 +TGS G G+ + A + P+ ELG +P ++ + DL + Sbjct: 226 GFTGSVGGGRALFNLAHERPEPIPFYGELGAINPTFIFPSAMRAKADL---ADQFVASMT 282 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGL 297 M GQ C P + ++ + ++ + S I + +V+ Sbjct: 283 MGCGQFCTKPGVVF---ALNTPETQAFIETAQSLI-RQQSPSTLLTPGIRDSYQSQVVSR 338 Query: 298 IEGQKVAYGGTGDAATRYIAPTILTDVD--PQSPVMQEEIFGPVLPIVCVRSLEEAIQFI 355 + + + + +T + + P +EEIFGP IV ++ + + Sbjct: 339 GSDDGIDVTFSQAESPCVASALFVTSSENWRKHPAWEEEIFGPQSLIVVCENVADMLSLS 398 Query: 356 NQREKPLALYMFSS--NDKVIKKMIAETS--SGGVAANDVIVH-----ITLHSLPFGGVG 406 L + ++ + + ++I +G + N +H P+ Sbjct: 399 EMLAGSLTATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGVEVGYAMVHGGPYPAST 458 Query: 407 NSGMGSYHGKKSFETFSH 424 +S + G ++ + Sbjct: 459 HSAS-TSVGAEAIHRWLR 475 >2Y53-A nrPDB Length = 534 Score = 156 bits (394), Expect = 3e-38, Method: Composition-based stats. Identities = 71/432 (16%), Positives = 152/432 (35%), Gaps = 42/432 (9%) Query: 3 KISEAVKRARA-AFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61 ++ A AR ++ R R +L + +L+Q + + A+ ++ Sbjct: 44 DLARAFSFAREDGGAALRALTYAQRAARLADIVKLLQAKRGDYYAIATANSGTTRNDSAV 103 Query: 62 EEVVYVLEEIEYMIQKLPEWA-----ADEPVEKTPQTQQDELYIHSEPL-GVVLVIGTWN 115 ++ + + Y + D E + + P GV L I +N Sbjct: 104 -DIDGGIFTLSYYAKLGASLGEVHALRDGSAESLSKDRSFSAQHVLSPTRGVALFINAFN 162 Query: 116 YPFNLTIQPMVGAIAAGNSVVLKPSELSE-NMASLLATIIPQY-LDKDLYPVINGGVPET 173 +P + A+ +G V++KP+ + ++A ++ L +I G Sbjct: 163 FPSWGLWEKAAPALLSGVPVIVKPATATAWLTQRMVADVVDAGILPPGALSIICGSSAGL 222 Query: 174 TELLKERFDHILYTGSTGVGKIIMTAAA--KHLTPVTLELGGKSPCYVDKNCDLDVAC-- 229 + ++ FD + +TGS + A + + ++ + + + D Sbjct: 223 LDQIRS-FDVVSFTGSADTAATLRAHPAFVQRGARLNVQADSLNSAILCADATPDTPAFD 281 Query: 230 ---RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRI 285 + + + SGQ C A + ++E LK L + G + G + Sbjct: 282 LFIKEVVREMTVKSGQKCTAIRRAFVPEAALEPVLEALKAKLAKITVGNPRNDAVRMGSL 341 Query: 286 ISARHFQRVMGLI----EGQKVAYGGTG---DAATRYIAPTI-----LTDVDPQSPVMQE 333 +S ++ V+ I E +AY + A IA + + + + ++ + Sbjct: 342 VSREQYENVLAGIAALREEAVLAYDSSAVPLIDADANIAACVAPHLFVVNDPDNATLLHD 401 Query: 334 -EIFGPVLPIVCVR--------SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAET--S 382 E+FGPV + R A+ + + L ++S++D + ++ E S Sbjct: 402 VEVFGPVASVAPYRVTTDTNALPEAHAVALARRGQGSLVASIYSNDDAHLGRLALELADS 461 Query: 383 SGGVAANDVIVH 394 G V A V Sbjct: 462 HGRVHAISPSVQ 473 >5J7I-A nrPDB Length = 488 Score = 131 bits (330), Expect = 7e-31, Method: Composition-based stats. Identities = 76/432 (17%), Positives = 153/432 (35%), Gaps = 56/432 (12%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + ++ ++ A+AA + +E++ +E+ L + Sbjct: 33 IQEVRNYLEEAKAAQKILEKMTQSEIDKIVESMANAAREEAGRLAAMAVEETGFGNVE-- 90 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 L+ + + V + +++ ++ ++P+G+V I P + Sbjct: 91 ----DKTLKNLFAANDVYNSIKDVKTVGIIRRDEENRVWEIAQPVGIVAGIIPSTNPTST 146 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYL-----DKDLYPVINGGVPETTE 175 I + A+ A N++V P + + A I+ + K L I T Sbjct: 147 VIFKALIAVKARNAIVFSPHPSAAKCTAEAARIMQEAAERAGAPKGLISCITQPTMAATN 206 Query: 176 LLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 L + D IL TG G ++ AA P G P Y+ ++ ++ A + I Sbjct: 207 ELMKHKLTDVILATGGPG----LVKAAYSSGKPAYGVGPGNVPVYIHESANIAKAVQLII 262 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQR 293 K + G C + +L D SI+ ++V +LK+ F + Q+ Sbjct: 263 QSKTFDYGTICASEQALLVDESIKEKVVAELKQQGAYFL--------------NEEEKQK 308 Query: 294 VMGLIE-----GQKVAYGGT---GDAATRYIAPTILTDVDPQSPVMQEEIF-----GPVL 340 V +I K+ + A I + V ++ V +E F P+L Sbjct: 309 VASIIMVNGSLNAKIVGKAPQVIAEMAGIEIPSDVKLLVAEETEVGKEYPFSIEKLSPIL 368 Query: 341 PIVCVRSLEEAIQFINQ----REKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHIT 396 V+ +EEA + + + + + ++KVI+ + +G + N Sbjct: 369 AFYIVKGMEEASELAQKLLEVGGLGHTVGIHAEDEKVIEAYTIDKPAGRIVVNAGTT--- 425 Query: 397 LHSLPFGGVGNS 408 FGG+G + Sbjct: 426 -----FGGIGAT 432 >3K9D-A nrPDB Length = 464 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 65/429 (15%), Positives = 143/429 (33%), Gaps = 49/429 (11%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 + ++ ++ A A Q ++A+ ++L + W Sbjct: 11 IQEVRNLIESANKAQKELAAMSQQQIDTIVKAIADAGYGAREKLAKMAHEETGFGIWQDK 70 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 + V+ + + I+ + + + + ++ + PLGVV + P + Sbjct: 71 VIKNVFASKHVYNYIKDMKTIGMLK------EDNEKKVMEVAVPLGVVAGLIPSTNPTST 124 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYL-----DKDLYPVINGGVPETTE 175 I + +I AGNS+V P + II + K + + T+ Sbjct: 125 VIYKTLISIKAGNSIVFSPHPNALKAILETVRIISEAAEKAGCPKGAISCMTVPTIQGTD 184 Query: 176 LLKERFDH--ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 L + D IL TG G ++ AA TP G P +++++ ++ A + I Sbjct: 185 QLMKHKDTAVILATG----GSAMVKAAYSSGTPAIGVGPGNGPAFIERSANIPRAVKHIL 240 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGE---------DAKKSRDYGR 284 K ++G C + ++ + + ++ + +K F + + + Sbjct: 241 DSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQGAHFLSDAEAVQLGKFILRPNGSMNP 300 Query: 285 IISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPV-MQEEIFGPVLPIV 343 I + Q + G T A R + I + + + E P+L Sbjct: 301 AIVGKSVQHIAN-------LAGLTVPADARVL---IAEETKVGAKIPYSREKLAPILAFY 350 Query: 344 CVRSLEEAIQFINQREK----PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS 399 + +EA + L + S + ++I++ + + N Sbjct: 351 TAETWQEACELSMDILYHEGAGHTLIIHSEDKEIIREFALKKPVSRLLVNTP-------- 402 Query: 400 LPFGGVGNS 408 GG+G + Sbjct: 403 GALGGIGAT 411 >3MY7-A nrPDB Length = 452 Score = 128 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 58/415 (13%), Positives = 130/415 (31%), Gaps = 26/415 (6%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 M+++ + R + A T + + A + L + Sbjct: 6 MAELDAMIARVKKAQEEFATYSQEQVDKIFRAASLAANQARIPLAQQAVEESGMGIVEDK 65 Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120 + + E I ++ ++ + +EP+G++ I P + Sbjct: 66 VIKNHFASEFI------YNKYKDEQTCGILEEDDNLGTMTIAEPVGIICGIVPTTNPTST 119 Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATII-----PQYLDKDLYPVINGGVPETTE 175 I + ++ N ++ P ++N + A ++ KD+ I+ E + Sbjct: 120 AIFKSLISLKTRNGIIFSPHPRAKNSTNDAAKLVLDAAVAAGAPKDIIGWIDQPSVELSN 179 Query: 176 LLKER--FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIA 233 L + IL TG G+ K AA P G P +D+ D+ A + Sbjct: 180 ALMKHDDIALILATGGPGMVK----AAYSSGKPAIGVGAGNVPVVIDETADIKRAVASVL 235 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQR 293 K ++G C + ++ + +++ E+ + +I + Sbjct: 236 MSKTFDNGVVCASEQAVIVVDEVYDEVKERFASHKAHVLSKTDADKVRKVLLIDGALNAK 295 Query: 294 VMGLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAI 352 ++G G A T+ + L V E++ P L + + E+A+ Sbjct: 296 IVGQPATAIAEMAGVKVPADTKVLIGEGLGKVSYDDAFAHEKL-SPTLGMFRADNFEDAV 354 Query: 353 QFI----NQREKPLALYMFSS---NDKVIKKMIAETSSGGVAANDVIVHITLHSL 400 ++++ N I+ + + + N H + L Sbjct: 355 AQAVTMVEIGGIGHTSGLYTNQDVNADRIRYFGDKMKTARILINIPTTHGGIGDL 409 >6D97-A nrPDB Length = 547 Score = 127 bits (320), Expect = 9e-30, Method: Composition-based stats. Identities = 76/389 (19%), Positives = 141/389 (36%), Gaps = 43/389 (11%) Query: 44 LVGALAADLHKNEWNAYYEEVVYVLEEIE-YMIQKLPEWAADEPVEKTPQTQQDELYIHS 102 + K+ A EV + +E + ++ A V Q+ Y Sbjct: 130 FAKLIQRVSPKSYQQAL-AEVQVSQKFLENFCGDQVRFLARSFAVPGNHLGQRSNGY--R 186 Query: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ-YLDKD 161 P G V +I +N+P + + ++GA+ GN VLK + + ++ L + Sbjct: 187 WPYGPVAIITPFNFPLEIPLLQLMGALYMGNKPVLKVDSKVSIVMEQMIRLLHDCGLPAE 246 Query: 162 LYPVINGGVPETTELLKE-RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVD 220 IN +LL E L+TGS+ V + + AA V LE G + Sbjct: 247 DMDFINSDGAVMNKLLLEANPKMTLFTGSSRVAEKL---AADLKGRVKLEDAGFDWKILG 303 Query: 221 KNC-DLDVACRRIAWGKFMNSGQTCVAPDYILCDPS-IQNQIVEKLKKSLKEFYGEDAKK 278 + ++D + SGQ C A + + + ++EK+KK + ED Sbjct: 304 PDVQEVDYVAWVCDQDAYACSGQKCSAQSVLFMHKNWSSSGLLEKMKKLSERRKLEDL-- 361 Query: 279 SRDYGRIISA------RHFQRVMGLIEGQKVAYGGTGDAATRY------IAPT-ILTDVD 325 G +++ H ++ I G KV +GG A + PT + ++ Sbjct: 362 --TIGPVLTVTTEAMIEHMNNLLK-IRGSKVLFGGEPLANHSIPKIYGAMKPTAVFVPLE 418 Query: 326 P-----QSPVMQEEIFGPVLPIVCVRSLE-----EAIQFINQREKPLALYMFSSNDKVIK 375 ++ +EIFGP + + EA + +N L + S++ ++ Sbjct: 419 EILKSGNFELVTKEIFGPFQVVTEYSEDQLELVLEACERMNAH---LTAAIVSNDPLFLQ 475 Query: 376 KMIAETSSGGVAA-NDVIVHITLHSLPFG 403 ++ + +G A + FG Sbjct: 476 DVLGRSVNGTTYAGIRARTTGAPQNHWFG 504 >4GHK-A nrPDB Length = 444 Score = 115 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 77/435 (17%), Positives = 136/435 (31%), Gaps = 71/435 (16%) Query: 23 LQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWA 82 + LEA+ R I+ L A A D+ + + V L + ++ + E Sbjct: 47 TAAKNAALEAVARAIERDAGALKAANARDVARAKDKGLDAAFVDRLTLSDKALKTMVEGL 106 Query: 83 ADEPVEKTPQTQQDELYIH---------SEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGN 133 P + L PLGV+ +I + N+TI + +GN Sbjct: 107 RQVATLPDPIGEMSNLKYRPSGIQVGQMRVPLGVIGII--YESRPNVTIDAAALCLKSGN 164 Query: 134 SVVLKPSELSENMASLLATIIPQYLDKDLYP------VINGGVPETTELLK--ERFDHIL 185 + +L+ + + LA +I + L + P V L+ E D I+ Sbjct: 165 ATILRGGSEALESNTALAKLIGEGLAEAGLPQDTVQVVETADRAAVGRLITMTEYVDVIV 224 Query: 186 YTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCV 245 G + + ++ A P+ L G YVD + A K G TC Sbjct: 225 PRGGKSLIERLINEAR---VPMIKHLDGICHVYVDDRASVTKALTVCDNAKTHRYG-TCN 280 Query: 246 APDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAY 305 + +L I ++ L GR+ + + + + Sbjct: 281 TMETLLVARGIAPAVLSPL------------------GRLYREKGVELRVDADARAVLEA 322 Query: 306 GGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALY 365 G G L D + + E PVL I V ++ AI+ IN+ Sbjct: 323 AGVGP----------LVDATDED--WRTEYLAPVLAIKIVDGIDAAIEHINEYGSHHTDA 370 Query: 366 MFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYH----------G 415 + + + + + E S V N S F G+G+ G Sbjct: 371 IVTEDHDRAMRFLREVDSASVMVN--------ASTRFADGFEFGLGAEIGISNDKLHARG 422 Query: 416 KKSFETFSHRRSCLV 430 E + + ++ Sbjct: 423 PVGLEGLTSLKYVVL 437 >2H5G-A nrPDB Length = 463 Score = 94.9 bits (235), Expect = 7e-20, Method: Composition-based stats. Identities = 79/435 (18%), Positives = 152/435 (34%), Gaps = 80/435 (18%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN---AY 60 + + + AR+ T + R + + L L+ +Q E++ A DL + E Sbjct: 31 VEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEILLANKKDLEEAEGRLAAPL 90 Query: 61 YEEVVYVLEEIEYMIQKLPEWAA------DEPVEKTPQTQQDELYIHSEPLGVVLVIGTW 114 + + ++ + L + AA + +T + EL + P+GV+LVI + Sbjct: 91 LKRLSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLVI--F 148 Query: 115 NYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLD----KDLYPVINGGV 170 + Q AIA+GN ++LK + + + +L + + L K+ ++N Sbjct: 149 ESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAVQLVN-TR 207 Query: 171 PETTEL--LKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVA 228 E +L L + D I+ GS+ + + I AA E G YVD +D Sbjct: 208 EEVEDLCRLDKMIDLIIPRGSSQLVRDIQKAAKGIPVMGHSE--GICHMYVDSEASVDKV 265 Query: 229 CRRIAWGKFMNSGQTCVAPDYILCDPS-----IQNQIVEKL-KKSLKEFYGEDAKKSRDY 282 R + K C A + +L + +QI++ L + +K G + Sbjct: 266 TRLVRDSKCEYPA-ACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTF 324 Query: 283 GRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI 342 ++ + YG D++ L I Sbjct: 325 SP-----------SEVKSLRTEYG----------------DLE--------------LCI 343 Query: 343 VCVRSLEEAIQFINQREKP--LALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSL 400 V ++++AI I + + + ++ + + S V N S Sbjct: 344 EVVDNVQDAIDHI--HKYGSSHTDVIVTEDENTAEFFLQHVDSACVFWN--------AST 393 Query: 401 PFGGVGNSGMGSYHG 415 F G+G+ G Sbjct: 394 RFSDGYRFGLGAEVG 408 >1VLU-A nrPDB Length = 468 Score = 93.4 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 88/446 (19%), Positives = 154/446 (34%), Gaps = 76/446 (17%) Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60 MS + K AR A + +T + R L + ++ + A DL + Sbjct: 13 MSSSQQIAKNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGL 72 Query: 61 YEEVVYVLE-----EIEYMIQKLPEWAA-DEPVEKTPQTQQ-DELYIHSE---PLGVVLV 110 + ++ L+ + E M+Q + + A ++PV K ++ D+ + P+GV+LV Sbjct: 73 ADSLLKRLDLFKGDKFEVMLQGIKDVAELEDPVGKVKMARELDDGLTLYQVTAPVGVLLV 132 Query: 111 IGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQ---------YLDKD 161 I + + +I +GN+ +LK + S N +A I+ + Sbjct: 133 I--FESRPEVIANITALSIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVG 190 Query: 162 LYPVINGGVPETTELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYV 219 +I + ++LL E D ++ GS + + I PV G Y+ Sbjct: 191 SVQLIE-TRQDVSDLLDQDEYIDLVVPRGSNALVRKIKDTTK---IPVLGHADGICSIYL 246 Query: 220 DKNCDLDVACRRIAWGKFMN-SGQTCVAPDYILCDPSIQN--QIVEKLK-------KSLK 269 D++ DL A R K +G C A + +L +P +++E L + K Sbjct: 247 DEDADLIKAKRISLDAKTNYPAG--CNAMETLLINPKFSKWWEVLENLTLEGGVTIHATK 304 Query: 270 EFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSP 329 + K + G ++ I+ + V D Sbjct: 305 DLKTAYFDKLNELG---------KLTEAIQCKTVDADEEQD------------------- 336 Query: 330 VMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAAN 389 +E L V S E AIQ IN + + N +K + S GV N Sbjct: 337 -FDKEFLSLDLAAKFVTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSGVYWN 395 Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415 S F G G+ G Sbjct: 396 --------ASTRFADGFRYGFGAEVG 413 >4JBE-A nrPDB Length = 445 Score = 89.5 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 62/408 (15%), Positives = 123/408 (30%), Gaps = 67/408 (16%) Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63 + E + A++A S P LE++ + ++ A A D+ K E Sbjct: 41 VEECARAAKSAAPSLSGAPDTAIDAALESMADRLLAHRDAVLAANAEDIAKAEAGGMSAG 100 Query: 64 VVYVLEEIEY----MIQKLPEWAA----DEPVEKTPQTQQDELYIHSEPLGVVLVIGTWN 115 ++ L E M +L A VE + L P+GV+ N Sbjct: 101 LLDRLTITESRLTDMADQLRLLAGAPHPQRTVELSTLDGGLRLVERRRPVGVIGA----N 156 Query: 116 Y--PFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATII------PQYLDKDLYPVIN 167 Y N+T+ + + N+ VL+ + A L ++ +D ++ ++ Sbjct: 157 YEARPNVTVDVASQLVKSRNAGVLRTGSAALKSAQRLLEVVIRPALTDSGIDANVVQLVP 216 Query: 168 GGVPETTELLK---ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCD 224 E L + ++ GS + + AA+H G YVD+ D Sbjct: 217 RPEREAAGALVRLPDLVPLVILRGSGESTRALALEAAQHGVRTLAHADGGGVLYVDEKAD 276 Query: 225 LDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR 284 D R + G C + +L ++ + + ++L E + Sbjct: 277 RD-TVRSLVVNSLDRLG-VCNRLNLLLIHDAVYEEFWPVVSEALAERGVSPSLP-----P 329 Query: 285 IISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVC 344 ++ + V + Sbjct: 330 YDHPIGYEWALDSEREATV-------------------------------------TVAR 352 Query: 345 VRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVI 392 V + EA++ N+ LA + + + + ++ GV N Sbjct: 353 VDGVAEAVRIANEETSGLAAGIATEDARAAEEFFDGYQGTGVFWNAPT 400 >1PDZ-A nrPDB Length = 434 Score = 34.4 bits (78), Expect = 0.097, Method: Composition-based stats. Identities = 25/145 (17%), Positives = 46/145 (31%), Gaps = 17/145 (11%) Query: 150 LATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGST------GVGKIIMTAAAKH 203 LA L + VINGG +L + F IL TG+T +G + Sbjct: 137 LANYDEVILPVPAFNVINGGSHAGNKLAMQEF-MILPTGATSFTEAMRMGTEVYHHLKAV 195 Query: 204 LTP-------VTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCV--APDYILCDP 254 + + GG +P ++ LD+ I + + + A Sbjct: 196 IKARFGLDATAVGDEGGFAPNILNNKDALDLIQEAIKKAGYTGKIEIGMDVAASEFYKQN 255 Query: 255 SIQN-QIVEKLKKSLKEFYGEDAKK 278 +I + ++ G+ + Sbjct: 256 NIYDLDFKTANNDGSQKISGDQLRD 280 >5MMM-i nrPDB Length = 208 Score = 32.1 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 9/67 (13%), Positives = 21/67 (31%), Gaps = 6/67 (8%) Query: 215 SPCYVDKNCDLDVACRRIAWGKFMNS-----GQTCVAPDYILCDPSIQNQIVEKLKKSLK 269 +P V + DL+ + G F G+ A ++ + + + + + Sbjct: 56 APVEVAETADLEKFVKSRLPGGFAAQTVIGTGRRKCAIARVVLQEGTG-KFIINYRDAKE 114 Query: 270 EFYGEDA 276 G Sbjct: 115 YLQGNPL 121 >5X8R-i nrPDB Length = 157 Score = 31.7 bits (71), Expect = 0.59, Method: Composition-based stats. Identities = 9/67 (13%), Positives = 21/67 (31%), Gaps = 6/67 (8%) Query: 215 SPCYVDKNCDLDVACRRIAWGKFMNS-----GQTCVAPDYILCDPSIQNQIVEKLKKSLK 269 +P V + DL+ + G F G+ A ++ + + + + + Sbjct: 5 APVEVAETADLEKFVKSRLPGGFAAQTVIGTGRRKCAIARVVLQEGTG-KFIINYRDAKE 63 Query: 270 EFYGEDA 276 G Sbjct: 64 YLQGNPL 70 >6C49-A nrPDB Length = 350 Score = 31.4 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 38/119 (31%), Gaps = 27/119 (22%) Query: 140 SELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTA 199 S L+ N + + + + + +I+G T TGS + ++ Sbjct: 259 STLAPNGSLHFLGLTLEPVPVSVGSLIDGAKSVTG----------SPTGSPAALRQLLKF 308 Query: 200 AAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQN 258 AA+ +EL L+ A R+ +SGQ A I+ Sbjct: 309 AARKKIAPQIEL--------FPMSQLNEAIERL------HSGQ---ARYRIVLKADFAE 350 >3DOD-A nrPDB Length = 448 Score = 31.4 bits (70), Expect = 0.92, Method: Composition-based stats. Identities = 8/26 (30%), Positives = 14/26 (53%) Query: 22 PLQFRIQQLEALQRLIQEQEQELVGA 47 P + R Q L L +L++E +E+ Sbjct: 189 PDECRDQCLRELAQLLEEHHEEIAAL 214 >3LOO-A nrPDB Length = 365 Score = 31.4 bits (70), Expect = 0.96, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 20/49 (40%), Gaps = 8/49 (16%) Query: 333 EEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAET 381 EEIF P + ++ + EAI + + + + I K IA Sbjct: 226 EEIF-PYVDVL-FGNETEAIALAKEFNYG------TEDLREIGKRIAAL 266 >5KQU-A nrPDB Length = 479 Score = 31.0 bits (69), Expect = 1.00, Method: Composition-based stats. Identities = 18/129 (13%), Positives = 37/129 (28%), Gaps = 18/129 (13%) Query: 223 CDLD------VACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDA 276 +LD + G ++N + L + ++ L+ Sbjct: 358 ANLDILERENLTANAADVGAYLNQRLRETFEGHPLVGEVRGDGMLAALEFMADREARTPF 417 Query: 277 KKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQ-----SPVM 331 + G +SA +E +A + P +LT + + Sbjct: 418 DPALKVGPKVSA-------ACLEDGMIARAMPHGDILGFAPPLVLTRAEADEIVGIAKAA 470 Query: 332 QEEIFGPVL 340 +E+ G VL Sbjct: 471 VDEVAGEVL 479 >1NNE-A nrPDB Length = 765 Score = 30.2 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 35/83 (42%), Gaps = 3/83 (3%) Query: 23 LQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWA 82 ++ + +++ L+ LI+ +E+E V + K + A E +L E++ L E A Sbjct: 481 MKEKEREVYRLEALIRRREEE-VFLEVRERAKRQAEALR-EAARILAELDVYA-ALAEVA 537 Query: 83 ADEPVEKTPQTQQDELYIHSEPL 105 + + ++ P+ Sbjct: 538 VRYGYVRPRFGDRLQIRAGRHPV 560 >2XH7-A nrPDB Length = 443 Score = 30.2 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 19/93 (20%), Positives = 26/93 (27%), Gaps = 16/93 (17%) Query: 157 YLDKDLYPVINGGVPETTELLKERFDHILYTGST------GVGKIIMTAAAKHLTP---- 206 L V+NGG L + F I TG+ +G + Sbjct: 145 VLPVPFLNVLNGGSHAGGALALQEF-MIAPTGAKTFAEALRIGSEVYHNLKSLTKKRYGA 203 Query: 207 ----VTLELGGKSPCYVDKNCDLDVACRRIAWG 235 V E GG +P LD+ I Sbjct: 204 SAGNVGDE-GGVAPNIQTAEEALDLIVDAIKAA 235 >1EWR-A nrPDB Length = 649 Score = 29.8 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 35/83 (42%), Gaps = 3/83 (3%) Query: 23 LQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWA 82 ++ + +++ L+ LI+ +E+E V + K + A E +L E++ L E A Sbjct: 365 MKEKEREVYRLEALIRRREEE-VFLEVRERAKRQAEALR-EAARILAELDVYA-ALAEVA 421 Query: 83 ADEPVEKTPQTQQDELYIHSEPL 105 + + ++ P+ Sbjct: 422 VRYGYVRPRFGDRLQIRAGRHPV 444 >1ZBM-A nrPDB Length = 280 Score = 29.8 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 7/51 (13%), Positives = 19/51 (37%), Gaps = 13/51 (25%) Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHIT 396 + +EAI++ + + L + + K+ + ND ++ Sbjct: 213 ENPDEAIEYAMKYSRGL-------DRERAKRFA------MMYVNDYTYNMP 250 >3QTP-A nrPDB Length = 441 Score = 29.8 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 28/135 (20%), Positives = 44/135 (32%), Gaps = 22/135 (16%) Query: 123 QPMVGAIAAGNSVVL---KPSELSENMASLLATII---PQYLDKDLYPVINGGVPETTEL 176 + G S+ + +E + LA + + + VINGG L Sbjct: 107 GKLGANAILGCSMSICRAAAAEKGLPLYKYLAELTGHKEMTMPVPCFNVINGGAHAGNAL 166 Query: 177 LKERFDHILYTGSTGVGKIIMTAA--------------AKHLTPVTLELGGKSPCYVDKN 222 + F I TG+T + + AA + T V E GG +P Sbjct: 167 AMQEF-MICPTGATNFHEALRMAAETYQCLKVVIKAKYGQDATNVGDE-GGFAPNVSGAR 224 Query: 223 CDLDVACRRIAWGKF 237 LD+ IA + Sbjct: 225 EALDLLVEAIAKAGY 239 >1EU1-A nrPDB Length = 780 Score = 29.8 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 31/145 (21%), Positives = 51/145 (35%), Gaps = 33/145 (22%) Query: 212 GGKSPCYVDKNCDLDVACRRIAWG----KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKS 267 G PC ++ D A R IA G F + GQ IL + + ++ + Sbjct: 664 AGHEPCLINP---ADAAARGIADGDVLRVFNDRGQ-------ILVGAKVSDAVMPGAIQI 713 Query: 268 LKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQ-KVAYGGTGDAATRYIAPTILTDVDP 326 + + + S + G + V+ L G K+A G G TIL DV+ Sbjct: 714 YEGGWYDPLDPSEE-GTL-DKYGDVNVLSLDVGTSKLAQGNCGQ--------TILADVEK 763 Query: 327 QSPVMQEEIFGPVLPIVCVRSLEEA 351 + PV + + + A Sbjct: 764 YAG-------APV-TVTVFDTPKGA 780 >2WVR-A nrPDB Length = 209 Score = 29.4 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 10/69 (14%), Positives = 23/69 (33%), Gaps = 4/69 (5%) Query: 16 SSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMI 75 + + R + L ++E E+ D +E+ V E ++YM Sbjct: 97 QYWKEV-AEKRRKALY---EALKENEKLHKEIEQKDNEIARLKKENKELAEVAEHVQYMA 152 Query: 76 QKLPEWAAD 84 + + + Sbjct: 153 ELIERLNGE 161 >3C3E-A nrPDB Length = 311 Score = 29.4 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 19/48 (39%), Gaps = 1/48 (2%) Query: 249 YILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMG 296 + + SI +++E +K G + G IIS + ++ Sbjct: 166 RGVSEASISPKVLEAFEKEENILIG-PSNPITSIGPIISLPGMRELLK 212 >2OYO-A nrPDB Length = 196 Score = 29.4 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 15/39 (38%) Query: 9 KRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGA 47 ++A A + R L R Q L A + E+ A Sbjct: 110 QKADAVAVNWRHADLTEREQALAAYAEKLTRHPAEVTAA 148 >2IPH-A nrPDB Length = 181 Score = 29.0 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 15/35 (42%), Gaps = 1/35 (2%) Query: 309 GDAATRYIAPTILTDVDPQSPVMQEEIFG-PVLPI 342 G +++PT+ P +E FG P+ I Sbjct: 13 GSGWGFWVSPTVFITTTHVIPTSAKEFFGEPLTSI 47 >4BRY-A nrPDB Length = 78 Score = 29.0 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 10/68 (14%), Positives = 22/68 (32%), Gaps = 4/68 (5%) Query: 16 SSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMI 75 + + R + L ++E E+ D +E+ V E ++YM Sbjct: 15 QYWKEV-AEKRRKALY---EALKENEKLHKEIEQKDNEIARLKKENKELAEVAEHVQYMA 70 Query: 76 QKLPEWAA 83 + + Sbjct: 71 ELIERLNG 78 >4FWI-B nrPDB Length = 334 Score = 29.0 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 47/131 (35%), Gaps = 22/131 (16%) Query: 19 RTRPLQFR---IQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMI 75 +T P R + L + L+ +E+EL ++ A + + ++ IE+ Sbjct: 56 KTLPPNGRILSGRVLYKGKDLLTMREEELRKIRWKEI-ALVPQAAQQSLNPTMKVIEHFK 114 Query: 76 Q----KLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQP-----MV 126 W+ E +EK + + + P V+ YP L+ + Sbjct: 115 DTVEAHGVRWSHSELIEKASEKLRM---VRLNPEAVLNS-----YPLQLSGGMKQRVLIA 166 Query: 127 GAIAAGNSVVL 137 A+ + VVL Sbjct: 167 LALLL-DPVVL 176 >1WQS-A nrPDB Length = 173 Score = 28.7 bits (63), Expect = 4.9, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 14/35 (40%), Gaps = 1/35 (2%) Query: 309 GDAATRYIAPTILTDVDPQSPVMQEEIFG-PVLPI 342 G +++PT+ P E FG P+ I Sbjct: 13 GSGWGFWVSPTVFITTTHVIPTGVREFFGEPIESI 47 >1MG2-A nrPDB Length = 390 Score = 28.7 bits (63), Expect = 5.3, Method: Composition-based stats. Identities = 16/84 (19%), Positives = 30/84 (35%), Gaps = 4/84 (4%) Query: 259 QIVEKLKKSLKEFYGEDAK--KSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYI 316 +I+E + Y D + +I RV+G+I+G + D + Sbjct: 39 RILEAPAPDARRVYVNDPAHAAAVTQQFVIDGEAG-RVIGMIDGGFLPNPVVADDGSFIA 97 Query: 317 AP-TILTDVDPQSPVMQEEIFGPV 339 T+ + + E+F PV Sbjct: 98 HASTVFSRIARGERTDYVEVFDPV 121 >1QNN-A nrPDB Length = 191 Score = 28.7 bits (63), Expect = 5.4, Method: Composition-based stats. Identities = 9/24 (37%), Positives = 14/24 (58%) Query: 220 DKNCDLDVACRRIAWGKFMNSGQT 243 +N DL+ ++ G F N+GQT Sbjct: 48 FENADLNTIVQKSEGGIFNNAGQT 71 >6B9O-A nrPDB Length = 981 Score = 28.7 bits (63), Expect = 6.3, Method: Composition-based stats. Identities = 8/47 (17%), Positives = 15/47 (31%), Gaps = 4/47 (8%) Query: 141 ELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187 E + ++ + + +NGG E D I +T Sbjct: 81 EQTPET----KELVRKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHT 123 >2FYR-A nrPDB Length = 194 Score = 28.3 bits (62), Expect = 6.7, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 15/35 (42%), Gaps = 1/35 (2%) Query: 309 GDAATRYIAPTILTDVDPQSPVMQEEIFG-PVLPI 342 G +++PT+ P +E FG P+ I Sbjct: 26 GSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSI 60 >2R6A-A nrPDB Length = 454 Score = 28.3 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 8/60 (13%), Positives = 21/60 (35%), Gaps = 1/60 (1%) Query: 43 ELVGALAADL-HKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIH 101 EL + + + + + V +EY + + E + + +T + + Y Sbjct: 73 ELAASEQLEEIGGVSYLSELADAVPTAANVEYYARIVEEKSVLRRLIRTATSIAQDGYTR 132 >3UF0-A nrPDB Length = 273 Score = 27.9 bits (61), Expect = 8.9, Method: Composition-based stats. Identities = 12/77 (15%), Positives = 20/77 (25%), Gaps = 12/77 (15%) Query: 160 KDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAA-AKHLTPVTLEL---GGKS 215 V+ G + G G ++ + V E+ GG + Sbjct: 30 AGRTAVVTGAGSGIGRAIAH--------GYARAGAHVLAWGRTDGVKEVADEIADGGGSA 81 Query: 216 PCYVDKNCDLDVACRRI 232 V DL+ A Sbjct: 82 EAVVADLADLEGAANVA 98 >3GTS-A nrPDB Length = 349 Score = 27.9 bits (61), Expect = 9.2, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 19/39 (48%), Gaps = 2/39 (5%) Query: 72 EYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLV 110 + + LPE +++P+ +T LY +P GVV Sbjct: 8 AWYVAALPEELSEKPLGRTILDTPLALY--RQPDGVVAA 44 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.156 0.451 Lambda K H 0.267 0.0475 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,450,818 Number of Sequences: 36641 Number of extensions: 904567 Number of successful extensions: 3730 Number of sequences better than 10.0: 144 Number of HSP's better than 10.0 without gapping: 213 Number of HSP's successfully gapped in prelim test: 49 Number of HSP's that attempted gapping in prelim test: 2512 Number of HSP's gapped (non-prelim): 287 length of query: 453 length of database: 10,336,785 effective HSP length: 100 effective length of query: 353 effective length of database: 6,672,685 effective search space: 2355457805 effective search space used: 2355457805 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 61 (27.9 bits)