BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P30566 (484 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2J91-A nrPDB 1001 0.0 5V4L-A nrPDB 686 0.0 5VKW-A nrPDB 643 0.0 5EYT-A nrPDB 541 e-154 1YIS-A nrPDB 436 e-122 4NLE-A nrPDB 240 1e-63 1F1O-A nrPDB 182 2e-46 2PFM-A nrPDB 172 2e-43 2X75-A nrPDB 162 2e-40 1C3C-A nrPDB 137 1e-32 1DOF-A nrPDB 105 6e-23 4EEI-A nrPDB 99 5e-21 1Q5N-A nrPDB 90 2e-18 3C8T-A nrPDB 87 1e-17 1RE5-A nrPDB 85 5e-17 2QGA-B nrPDB 80 2e-15 2FEL-A nrPDB 70 2e-12 4EFC-A nrPDB 70 3e-12 4MX2-A nrPDB 63 3e-10 5XNZ-A nrPDB 62 5e-10 3BHG-A nrPDB 58 9e-09 5E3V-A nrPDB 52 4e-07 4NSL-A nrPDB 52 4e-07 2PTS-A nrPDB 52 7e-07 1YFM-A nrPDB 47 3e-05 1FUP-A nrPDB 45 5e-05 3GTD-A nrPDB 44 1e-04 3RRP-A nrPDB 44 1e-04 5UPP-A nrPDB 42 4e-04 3TV2-A nrPDB 42 5e-04 3RD8-A nrPDB 41 0.001 3QBP-A nrPDB 39 0.004 1VDK-A nrPDB 38 0.010 3R6Q-A nrPDB 37 0.022 4ADL-A nrPDB 35 0.057 3OCE-A nrPDB 33 0.25 6N1M-A nrPDB 32 0.56 4HGV-A nrPDB 32 0.56 4HOQ-A nrPDB 32 0.57 1JSW-A nrPDB 31 1.2 6BAC-A nrPDB 31 1.3 2OBA-A nrPDB 30 2.0 >2J91-A nrPDB Length = 503 Score = 1001 bits (2589), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/481 (99%), Positives = 481/481 (100%) Query: 1 MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE 60 MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE Sbjct: 23 MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE 82 Query: 61 QIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD 120 QI+EMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD Sbjct: 83 QIREMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD 142 Query: 121 LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC 180 LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC Sbjct: 143 LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC 202 Query: 181 MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG 240 MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG Sbjct: 203 MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG 262 Query: 241 QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR 300 QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR Sbjct: 263 QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR 322 Query: 301 SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE 360 SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE Sbjct: 323 SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE 382 Query: 361 GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD 420 GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD Sbjct: 383 GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD 442 Query: 421 NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA 480 NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA Sbjct: 443 NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA 502 Query: 481 E 481 E Sbjct: 503 E 503 >5V4L-A nrPDB Length = 479 Score = 686 bits (1769), Expect = 0.0, Method: Compositional matrix adjust. Identities = 333/469 (71%), Positives = 382/469 (81%), Gaps = 2/469 (0%) Query: 11 DSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLE 70 DSY++PL+SRYAS EM +FS +F TWR+LWL LA AE+ LGL I+D I++MK+NLE Sbjct: 2 DSYQTPLSSRYASKEMSKLFSSGARFGTWRKLWLNLAIAEKELGLAISDAAIEQMKANLE 61 Query: 71 --NIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNAL 128 K+AAEEEK+ RHDVMAHVHTFG P+AAGIIHLGATSCYV DN DLI LR+ L Sbjct: 62 LDEAQMKVAAEEEKKRRHDVMAHVHTFGTVAPEAAGIIHLGATSCYVTDNADLIFLRDGL 121 Query: 129 DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKR 188 D+LLPKLA VISRLA+FAK+ LPTLGFTHFQPAQLTTVGKR LWIQ+L DL+NL+R Sbjct: 122 DILLPKLATVISRLANFAKQYRDLPTLGFTHFQPAQLTTVGKRATLWIQELLWDLRNLQR 181 Query: 189 VRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVD 248 RDDL FRGVKGTTGTQASFL LF+GD KVE LDK VTE GF A+ +TGQTY+RK+D Sbjct: 182 ARDDLGFRGVKGTTGTQASFLALFDGDHAKVEALDKRVTELFGFPYAYPVTGQTYSRKID 241 Query: 249 IEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLA 308 +VL L+S GA+VHKI TDIRLLANLKE+EEPFEK QIGSSAM YKRNPMR ER CSLA Sbjct: 242 ADVLGPLSSFGATVHKIATDIRLLANLKEIEEPFEKDQIGSSAMAYKRNPMRCERACSLA 301 Query: 309 RHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKV 368 RHLM + + L T+SVQW ERTLDDSANRR+ + EAFLTAD +L TLQNISEGLVVYP+V Sbjct: 302 RHLMAIYQNTLMTSSVQWLERTLDDSANRRVTIPEAFLTADILLTTLQNISEGLVVYPRV 361 Query: 369 IERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQ 428 I RRI QELPFMATENIIMA+VKAGG RQ+CHEKIRVLS QA +VVK+EGG+NDLI+R++ Sbjct: 362 IGRRISQELPFMATENIIMAIVKAGGDRQECHEKIRVLSHQAGAVVKEEGGENDLIDRVK 421 Query: 429 VDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMK 477 D YF PI QLD LLDP +F GRA +QV FL+E V P LKPYE +K Sbjct: 422 NDEYFKPIWGQLDALLDPRTFVGRAPEQVDGFLKEWVEPALKPYEEALK 470 >5VKW-A nrPDB Length = 482 Score = 643 bits (1659), Expect = 0.0, Method: Compositional matrix adjust. Identities = 314/466 (67%), Positives = 366/466 (78%), Gaps = 3/466 (0%) Query: 11 DSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLP-ITDEQIQEMKSNL 69 D Y +PL+SRYAS EM +FS R +F TWR+LWL LA AE+ +GL ITDE I++MK +L Sbjct: 5 DKYSTPLSSRYASEEMSKIFSLRNRFSTWRKLWLNLAIAEKEVGLSVITDEAIEQMKQHL 64 Query: 70 ENIDFKM--AAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNA 127 E D ++ AA EE ++RHDVMAHVH FG CP AAGIIHLGATSC+V DN DLI LR+A Sbjct: 65 EITDKEIQDAAVEEAKVRHDVMAHVHVFGETCPSAAGIIHLGATSCFVTDNADLIFLRDA 124 Query: 128 LDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLK 187 D+L+PKL VI RL+ FA E LP LG+THFQPAQLTTVGKR LW+Q+L DL+N+ Sbjct: 125 YDVLIPKLVNVIDRLSKFALEYKDLPVLGWTHFQPAQLTTVGKRATLWLQELLWDLRNMV 184 Query: 188 RVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKV 247 R R+D+ RGVKGTTGTQASFL LF GD KVE+LDK V E GF + +TGQTY+RK+ Sbjct: 185 RARNDIGLRGVKGTTGTQASFLSLFHGDHDKVEELDKRVVELLGFDIVYPVTGQTYSRKI 244 Query: 248 DIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSL 307 DI+VLS LAS GA+ HK TDIRLLANLKE+EEPFEK QIGSSAM YKRNPMR ER CSL Sbjct: 245 DIDVLSPLASFGATAHKFATDIRLLANLKEIEEPFEKSQIGSSAMAYKRNPMRCERVCSL 304 Query: 308 ARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPK 367 ARHL L D +QTASVQWFERTLDDSA RRI L AFLT D +L+T+ NI+ GLVVYPK Sbjct: 305 ARHLGGLFNDAVQTASVQWFERTLDDSAIRRISLPSAFLTVDILLSTMLNITSGLVVYPK 364 Query: 368 VIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERI 427 VIERRI ELPFMATENIIMAMV+ GGSRQDCHE+IRVLS QA++VVKQEGGDNDLIERI Sbjct: 365 VIERRINSELPFMATENIIMAMVEKGGSRQDCHEEIRVLSHQASAVVKQEGGDNDLIERI 424 Query: 428 QVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYE 473 + YF PI + LD LLDP +F GRA QQ ++F++ +V LKP+E Sbjct: 425 KSTEYFKPIWNDLDTLLDPKTFVGRAPQQTEKFVKNDVANALKPFE 470 >5EYT-A nrPDB Length = 497 Score = 541 bits (1393), Expect = e-154, Method: Compositional matrix adjust. Identities = 268/476 (56%), Positives = 353/476 (74%), Gaps = 2/476 (0%) Query: 11 DSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLE 70 + YR+PL RYAS EM F ++ K WRQLW+WLAE ++ LG ITDEQI EMKS + Sbjct: 22 EEYRNPLTKRYASREMVCNFGEKRKVILWRQLWIWLAETQKELGFDITDEQINEMKSQRD 81 Query: 71 NIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDL 130 ++DF AA EEK RHDVMAHV+TF CPKAA IIHLGATSC+VGDN DLI+L++ L++ Sbjct: 82 SVDFGTAAAEEKARRHDVMAHVYTFALACPKAAPIIHLGATSCFVGDNADLIMLKDGLNI 141 Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 LLPK+AR I RLA A SL L TH QPAQ TT+G+R C+WIQDL +DL+NL+R++ Sbjct: 142 LLPKVARCIDRLAKKAMLHKSLICLARTHLQPAQPTTMGRRICMWIQDLLLDLENLERLK 201 Query: 191 DD-LRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDI 249 + +RFRG KG GTQASF+ LF+GD KV +LD+++T+K+GF+R++ +TGQTY RKVDI Sbjct: 202 NHTIRFRGAKGAVGTQASFMDLFQGDHQKVIKLDEILTKKSGFQRSWCVTGQTYPRKVDI 261 Query: 250 EVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLAR 309 E+ + L+++GA+VHKICTDIRLL++ E+EEPFE +QIGSSAMPYKRNP+RSER CSLAR Sbjct: 262 EITNALSNIGATVHKICTDIRLLSSFHEVEEPFETKQIGSSAMPYKRNPIRSERACSLAR 321 Query: 310 HLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVI 369 +LM + + T SVQW ER+LDDSA RRI L EAFL AD L LQNI+EGL+VYP V+ Sbjct: 322 YLMHISTSMVSTVSVQWLERSLDDSAIRRIVLPEAFLAADACLTLLQNIAEGLIVYPMVM 381 Query: 370 ERRIRQELPFMATENIIMAMVKAGGS-RQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQ 428 E + ELPF+ E I++ MV G + RQ+CHE++R S +AA+ +K +G N L++++ Sbjct: 382 EANLNSELPFLVVERILVKMVSEGAANRQECHERLRKHSHEAAAEIKLKGLKNSLMDKLL 441 Query: 429 VDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKAELCL 484 D YF+PIHS L +LDPS GRA +QV+ FL EV P + Y+ + + + + + Sbjct: 442 NDYYFAPIHSLLPTVLDPSYMIGRAVEQVEVFLNTEVDPAIHSYKDCLALNSNITI 497 >1YIS-A nrPDB Length = 478 Score = 436 bits (1120), Expect = e-122, Method: Compositional matrix adjust. Identities = 220/469 (46%), Positives = 303/469 (64%), Gaps = 8/469 (1%) Query: 8 GSPDSYRSPLASRYA--SPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLP-ITDEQIQE 64 S D + S L++RY SP + + S+ K WRQLW+WLAEAE+ LGL +T + I E Sbjct: 2 ASEDKFESVLSTRYCKNSP-LVSILSETNKATLWRQLWIWLAEAEKELGLKQVTQDAIDE 60 Query: 65 MKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIIL 124 MKSN + D+ EE++L+HDVMAH H FG CP AAGIIHLGATSC+V DN DLI Sbjct: 61 MKSNRDVFDWPFIRSEERKLKHDVMAHNHAFGKLCPTAAGIIHLGATSCFVQDNADLIAY 120 Query: 125 RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQ 184 R+++D +L + A VI RLA F+ + + T+G TH+Q A L TVGKR LW Q+L M Q Sbjct: 121 RDSIDHILKRFATVIDRLAAFSLKNKEVVTVGRTHYQTASLVTVGKRGVLWAQELLMAFQ 180 Query: 185 NLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYT 244 +L RD +RFRG+KG TGTQ SFL LF GD+ KVE LD++VT+KA F F+ITGQTY+ Sbjct: 181 SLSEFRDKMRFRGIKGATGTQDSFLTLFAGDESKVEALDELVTKKANFSNRFLITGQTYS 240 Query: 245 RKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERC 304 R+ D +++ L+ LGA+ K+CTDIR+L E+ EPFEK QIGSSAMPYK+NPM+SERC Sbjct: 241 RQQDSQLVFSLSLLGAAAKKVCTDIRVLQAFGELLEPFEKDQIGSSAMPYKKNPMKSERC 300 Query: 305 CSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVV 364 C+L+R L+ + L + Q ERTLDDSA RR+ + + LTA+ +L TLQNI EGL V Sbjct: 301 CALSRKLINAPQEALTILADQGLERTLDDSAGRRMLIPDVLLTAEALLTTLQNIFEGLSV 360 Query: 365 YPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLI 424 +++ + E+ F+ E +M + + G RQ H IR + +A + + D I Sbjct: 361 QTDNVKKIVEDEIAFLGLEKAMMMLTEEGVDRQQAHAVIRKTALEAKQLQATQKVD---I 417 Query: 425 ERIQVDAYFSPIHSQLDHLL-DPSSFTGRASQQVQRFLEEEVYPLLKPY 472 + D +F + ++ L+ +P +FTGR Q + F+ +E+ P + Y Sbjct: 418 RQTMADPFFDSVRDRVVGLVNNPINFTGRCVSQTESFIAKELKPTIDKY 466 >4NLE-A nrPDB Length = 488 Score = 240 bits (612), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 153/442 (34%), Positives = 223/442 (50%), Gaps = 3/442 (0%) Query: 17 LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKM 76 LA+RYAS EM ++S K R+LWL + A+ LG+ + D +++ + LEN+D + Sbjct: 23 LANRYASDEMVAIWSPEAKIIAERRLWLAVLRAQAELGVAVPDGVVEDYERVLENVDLES 82 Query: 77 AAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLA 136 A E+ RHDV A + F +H G TS + +N + + +R +L+L+ Sbjct: 83 IAARERVTRHDVKARIEEFNALAGHEH--VHKGMTSRDLTENVEQLQIRQSLELVFSHGV 140 Query: 137 RVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFR 196 V++RLA+ A L G +H AQ TT+GKR ++ + L L+ + D R Sbjct: 141 AVVARLAERAVVYRDLVMAGRSHNVAAQATTLGKRFASAAEETLVALTRLRELIDRYPLR 200 Query: 197 GVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLA 256 GVKG GT L LF GD K+ L++ V E GF F GQ Y R +D +VLS L Sbjct: 201 GVKGPMGTAQDMLDLFGGDVGKLADLERRVAEFLGFTEVFTSVGQVYPRSLDHDVLSALV 260 Query: 257 SLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVM 316 GA + IRL+A + + E F Q+GSSAMP+K N ER L L Sbjct: 261 QFGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYAS 320 Query: 317 DPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQE 376 + A QW E + S RR+ L +AF D T + + YP VI+R + + Sbjct: 321 MAAELAGAQWNEGDVFCSVVRRVALPDAFFAIDGQTETFLTVLDEFGAYPAVIQRELDRY 380 Query: 377 LPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPI 436 LPF+AT I+MA V+AG R+ HE I+ + A ++++G + DLI+R+ D Sbjct: 381 LPFLATTRILMAAVRAGVGREAAHEVIKEHAVAVALAMREQGREPDLIDRLAGDPRLPLD 440 Query: 437 HSQLDHLL-DPSSFTGRASQQV 457 L+ L D +FTG A QV Sbjct: 441 KVALEAALEDKQAFTGAAGDQV 462 >1F1O-A nrPDB Length = 431 Score = 182 bits (463), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 120/396 (30%), Positives = 203/396 (51%), Gaps = 16/396 (4%) Query: 17 LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKM 76 + RY+ PEM +++D +F+ W ++ + EA LG+ I E ++ M+ N + D Sbjct: 1 MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGV-IPKEDVKVMRENA-SFDINR 58 Query: 77 AAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLA 136 E EK RHDV+A + +H G TS V D +L+ A D+LL L Sbjct: 59 ILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTALSYLLKQANDILLKDLE 118 Query: 137 RVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFR 196 R + + + AKE +G TH A+ TT G + LW +++ +L+ K+ + + Sbjct: 119 RFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEEMKRNLERFKQAKAGIEVG 178 Query: 197 GVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLA 256 + G GT A+ D VEQ V EK G K A I T QT R + ++ LA Sbjct: 179 KISGAVGTYANI-------DPFVEQY---VCEKLGLKAAPIST-QTLQRDRHADYMATLA 227 Query: 257 SLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTL 314 + S+ K +IR L + +E+EE F K Q GSSAMP+KRNP+ SE +AR + Sbjct: 228 LIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSENMTGMARVIRGY 287 Query: 315 VMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIR 374 +M + + W ER + S+ RI L +A + + +LN NI + L V+P+ ++R + Sbjct: 288 MMTAYENVPL-WHERDISHSSAERIILPDATIALNYMLNRFSNIVKNLTVFPENMKRNMD 346 Query: 375 QELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQA 410 + L + ++ +++A++ G +R++ ++ ++ + +A Sbjct: 347 RTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEA 382 >2PFM-A nrPDB Length = 444 Score = 172 bits (437), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 118/407 (28%), Positives = 202/407 (49%), Gaps = 18/407 (4%) Query: 8 GSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKS 67 GS + + SRY PEM ++++ KF+ W ++ + EA LG I E +++++ Sbjct: 1 GSSHHHHHHMISRYTRPEMGAIWTEENKFKAWLEVEILACEAWAELG-DIPKEDVKKIRE 59 Query: 68 NLENIDFKMAAEEEKRLRHDVMAHVHTFGH--CCPKAAGIIHLGATSCYVGDNTDLIILR 125 + + D E EK RHDV+A + +H G TS V D IL+ Sbjct: 60 HA-SFDIDRIYEIEKETRHDVVAFTRAVSETPALGEERKWVHYGLTSTDVVDTALSYILK 118 Query: 126 NALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQN 185 A +++L L +S LA+ AKE +G TH A+ TT G + LW +++ +++ Sbjct: 119 QANEIILKDLENFVSILANKAKEHKYTIMMGRTHGVHAEPTTFGLKLGLWYEEMKRNVER 178 Query: 186 LKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTR 245 K+ + +R + G GT A+ E K V E G + A I T QT R Sbjct: 179 FKQAANTVRVGKLSGAVGTYANIDPFVE----------KYVCENLGLEAAPIST-QTLQR 227 Query: 246 KVDIEVLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSER 303 +S LA + S+ K+ +IR L + +E+EE F K Q GSSAMP+KRNP+ SE Sbjct: 228 DRHAHYMSTLALIATSIEKMAVEIRGLQKSETREVEEAFAKGQKGSSAMPHKRNPIGSEN 287 Query: 304 CCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLV 363 LAR + +M + + W ER + S+ R+ L +A + + +LN NI + L Sbjct: 288 MTGLARVIRGYMMTAYENVPL-WHERDISHSSAERVILPDATIALNYMLNRFGNIVKNLT 346 Query: 364 VYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQA 410 VYP+ ++R + + + ++ +++ ++ G R++ ++ ++ + +A Sbjct: 347 VYPENMKRNMTRTYGLIYSQRVMLTLIDKGMVREEAYDIVQPKAMEA 393 >2X75-A nrPDB Length = 431 Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 115/441 (26%), Positives = 216/441 (48%), Gaps = 27/441 (6%) Query: 17 LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLG-LPITDEQIQEMKSNLENIDFK 75 + RY+ EM +++D+ ++ W ++ + EA LG +P D +Q+++ N + ++ + Sbjct: 1 MIERYSREEMSNIWTDQNRYEAWLEVEILACEAWSELGHIPKAD--VQKIRQNAK-VNVE 57 Query: 76 MAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKL 135 A E E+ RHDV+A + +H G TS V D +++ A D++ L Sbjct: 58 RAQEIEQETRHDVVAFTRQVSETLGEERKWVHYGLTSTDVVDTALSFVIKQANDIIEKDL 117 Query: 136 ARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRF 195 R I LA+ AK +G TH A+ TT G + LW ++ +LQ K+VR+++ Sbjct: 118 ERFIDVLAEKAKNYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMQRNLQRFKQVREEIEV 177 Query: 196 RGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVL 255 + G GT A+ +++ V + G A + T QT R ++ L Sbjct: 178 GKMSGAVGTFANI----------PPEIESYVCKHLGIGTAPVST-QTLQRDRHAYYIATL 226 Query: 256 ASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMT 313 A + S+ K +IR L +E+EE F K Q GSSAMP+KRNP+ SE ++R + Sbjct: 227 ALIATSLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNPIGSENITGISRVIRG 286 Query: 314 LVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRI 373 + + + W ER + S+ RI L + + D LN NI + L V+ + I Sbjct: 287 YITTAYENVPL-WHERDISHSSAERIMLPDVTIALDYALNRFTNIVDRLTVFEDNMRNNI 345 Query: 374 RQELPFMATENIIMAMVKAGGSRQDCHEKIR---VLSQQAAS----VVKQEGGDNDLIER 426 + + ++ +++A++ G R++ ++K++ ++S + + +++Q+ ++ + Sbjct: 346 DKTFGLIFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRELIEQDESITSVLTK 405 Query: 427 IQVDAYFSPIH--SQLDHLLD 445 ++D F P H +Q+D + + Sbjct: 406 EELDECFDPKHHLNQVDTIFE 426 >1C3C-A nrPDB Length = 429 Score = 137 bits (345), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 112/449 (24%), Positives = 203/449 (45%), Gaps = 32/449 (7%) Query: 20 RYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAAE 79 RY+ M ++++ K+R W ++ L + A + LG+ + + E N ID ++ + Sbjct: 3 RYSLSPMKDLWTEEAKYRRWLEVELAVTRAYEELGM--IPKGVTERIRNNAKIDVELFKK 60 Query: 80 EEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVI 139 E++ HDV+A V G + + H G TS V D + + L A +LL L Sbjct: 61 IEEKTNHDVVAFVEGIGSMIGEDSRFFHYGLTSSDVLDTANSLALVEAGKILLESLKEFC 120 Query: 140 SRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVK 199 L + A PT+G TH A+ T+ G + W ++ ++Q L+R +++ + + Sbjct: 121 DVLWEVANRYKHTPTIGRTHGVHAEPTSFGLKVLGWYSEMKRNVQRLERAIEEVSYGKIS 180 Query: 200 GTTGTQASFLQLFEGDDHKVEQLDKMVTEKA----GFKRAFIITGQTYTRKVDIEVLSVL 255 G G A+ + V EKA G K + T Q R LS L Sbjct: 181 GAVGNYAN--------------VPPEVEEKALSYLGLKPEPVST-QVVPRDRHAFYLSTL 225 Query: 256 ASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMT 313 A + A + +I +IR L + E+EEPF K Q GSSAMP+K+NP+ ER L+R +M Sbjct: 226 AIVAAGIERIAVEIRHLQRTEVLEVEEPFRKGQRGSSAMPHKKNPITCERLTGLSR-MMR 284 Query: 314 LVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRI 373 +DP W ER + S+ R +A T ++ T N+ + V + +++ I Sbjct: 285 AYVDPSLENIALWHERDISHSSVERYVFPDATQTLYYMIVTATNVVRNMKVNEERMKKNI 344 Query: 374 RQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYF 433 + ++ +++ +++ G +R++ ++ ++ + +K + +E + D Sbjct: 345 DLTKGLVFSQRVLLKLIEKGLTRKEAYDIVQ------RNALKTWNSEKHFLEYLLEDEEV 398 Query: 434 SPI--HSQLDHLLDPSSFTGRASQQVQRF 460 + +L+ L D S + +RF Sbjct: 399 KKLVTKEELEELFDISYYLKHVDHIFERF 427 >1DOF-A nrPDB Length = 403 Score = 105 bits (261), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 106/394 (26%), Positives = 185/394 (46%), Gaps = 25/394 (6%) Query: 15 SPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDF 74 SP RY S E+ +F++ + ++ L A + LG+ E+ K N ++ Sbjct: 4 SPFDWRYGSEEIRRLFTNEAIINAYLEVERALVCALEELGVA---ERGCCEKVNKASVSA 60 Query: 75 KMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPK 134 E+ HD+++ V +H GATS + D +++R AL + K Sbjct: 61 DEVYRLERETGHDILSLVLLLEQ--KSGCRYVHYGATSNDIIDTAWALLIRRALAAVKEK 118 Query: 135 LARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLR 194 V +LA A++ +L +G TH Q A+ T+G + + +L + + L + +R Sbjct: 119 ARAVGDQLASMARKYKTLEMVGRTHGQWAEPITLGFKFANYYYELYIACRQLALAEEFIR 178 Query: 195 FRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSV 254 + + G GT AS+ +L ++ + V E+ G +IT Q R+ + S Sbjct: 179 AK-IGGAVGTMASWGELGL-------EVRRRVAERLGLPH-HVITTQVAPRESFAVLASA 229 Query: 255 LASLGASVHKICTDIRLLANLKEMEEP----FEKQQIGSSAMPYKRNPMRSERCCSLARH 310 LA + A ++ +IR E+ P + GSSAMP+K NP SER SLAR+ Sbjct: 230 LALMAAVFERLAVEIR------ELSRPEIGEVVEGGGGSSAMPHKANPTASERIVSLARY 283 Query: 311 LMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIE 370 + L + ++ W ER L +SAN R+ + EA L D IL + + + + + + I Sbjct: 284 VRALTHVAFENVAL-WHERDLTNSANERVWIPEALLALDEILTSALRVLKNVYIDEERIT 342 Query: 371 RRIRQELPFMATENIIMAMVKAGGSRQDCHEKIR 404 +++ LP++ TE + M+K G SR + ++K + Sbjct: 343 ENLQKALPYILTEFHMNRMIKEGASRAEAYKKAK 376 >4EEI-A nrPDB Length = 438 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 94/408 (23%), Positives = 186/408 (45%), Gaps = 32/408 (7%) Query: 17 LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNL--ENIDF 74 + RY E+ +++D K+ ++ L + EA + +P ++ + E +D Sbjct: 1 MIKRYDVAEISKIWADENKYAKMLEVELAILEALEDRMVPKGTAAEIRARAQIRPERVD- 59 Query: 75 KMAAEEEKRLRHDVMAHVHTFGHCCPKAAG-IIHLGATSCYVGDNTDLIILRNALDLLLP 133 E EK +HD++A + G H G TS + D+ + +R+++ ++ Sbjct: 60 ----EIEKVTKHDIIAFCTSIAEQFTAETGKFFHFGVTSSDIIDSALSLQIRDSMSYVIK 115 Query: 134 KLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDD- 192 L + L A+E + T+G +H A+ + G++ + L++LK + D Sbjct: 116 DLEALCDSLLTKAEETKEIITMGRSHGMFAEPMSFGQKFLGAYVEFKRRLKDLKDFQKDG 175 Query: 193 --LRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIE 250 ++F G G ++ L D+ K + + E+ ++ Q R + Sbjct: 176 LTVQFSGAVG------NYCILTTEDEKKAADILGLPVEE--------VSTQVIPRDRIAK 221 Query: 251 VLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLA 308 ++S+ + +++ ++ +IR L +++ E+ E F K Q GSS MP+K+NP+ +E +A Sbjct: 222 LISIHGLIASAIERLAVEIRHLHRSDVFEVYEGFSKGQKGSSTMPHKKNPISTENLTGMA 281 Query: 309 RHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKV 368 R L + V L+ V W ER + S+ R L + F L ++N + LVV + Sbjct: 282 RMLRSHVSIALENC-VLWHERDISHSSAERFYLPDNFGIMVYALRRMKNTIDNLVVQRDI 340 Query: 369 IERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQ 416 IE R+R ++++ + + R+DC++ + QQ A +KQ Sbjct: 341 IEDRVRSTSAYLSSFYLHFLVANTPFMREDCYK----IVQQVAFDLKQ 384 >1Q5N-A nrPDB Length = 454 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 111/459 (24%), Positives = 198/459 (43%), Gaps = 32/459 (6%) Query: 18 ASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLG-LPITDEQI--QEMKSNLENIDF 74 AS + ++ +FSDR + + LA+A+ +G +P + + + K+ ++ IDF Sbjct: 9 ASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIQRAAKTAIDKIDF 68 Query: 75 KMAAEEEKRLRHDVMAHVHTFGHCCPKA----AGIIHLGATSCYVGDNTDLIILRNALDL 130 A + + V A A +H GATS + D ++ R+AL + Sbjct: 69 DALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAI 128 Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 + ++ + A+ +G T Q A T+G + W DL + ++ Sbjct: 129 VQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIK 188 Query: 191 DDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVD-- 248 + + G G+ AS + +V E + T T+ + D Sbjct: 189 ARVLVAQLGGAVGSLASL-----------QDQGSIVVEAYAKQLKLGQTACTWHGERDRI 237 Query: 249 IEVLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCS 306 +E+ SVL + +V K+ D L+ + E+ EP K + GSS MP+KRNP+ + + Sbjct: 238 VEIASVLGIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLA 297 Query: 307 LARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAF-LTADTILNTLQNISEGLVVY 365 A + L M + + VQ ER+L + L E F LTA + TL ++ +G+ V Sbjct: 298 AANRVPAL-MSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTL-DVLKGMEVN 355 Query: 366 PKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIE 425 + + + I + E ++MA+ G R + H + + A V ++ D+I Sbjct: 356 AENMHQNIECTHGLIMAEAVMMALAPHMG-RLNAHHVVEAACKTA---VAEQKHLKDIIS 411 Query: 426 RI-QVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEE 463 ++ +V YF+P SQLD + P S+ G Q+ L+E Sbjct: 412 QVDEVKQYFNP--SQLDEIFKPESYLGNIQDQIDAVLQE 448 >3C8T-A nrPDB Length = 451 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 111/463 (23%), Positives = 188/463 (40%), Gaps = 37/463 (7%) Query: 12 SYRSPLASR-YASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLE 70 S SPL R +A +M +FS + + + LA A+ LG+ I E + Sbjct: 2 SLDSPLYGRSFADDKMRELFSAQSFISRCVETEVALARAQARLGI------IPEDAAAGI 55 Query: 71 NIDFKMAAEEEKRLRHD-------VMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLII 123 + A E +RLR D ++ V +A +H GAT+ + D ++ Sbjct: 56 TAAARTFAPEMERLRDDTEIVGYPILPLVEQLSAHAGEAGKYLHWGATTQDIMDTATVLQ 115 Query: 124 LRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDL 183 +R+ L L+ ++ V LA A+ P G TH Q A T G + +W+ Sbjct: 116 IRDGLALISRRIESVRKALAALARNHRDTPMAGRTHLQHALPVTFGYKAAVWLSAFDRHA 175 Query: 184 QNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTY 243 L+ + + G +GT AS LD V + + + T+ Sbjct: 176 ARLEEISPRVLVVEFSGASGTLASL---------GTRGLD--VQRELARELNLGVPSITW 224 Query: 244 --TRKVDIEVLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPM 299 R E + LA + S+ K+ DI ++ L E+ EPF + + SS MP K+NP+ Sbjct: 225 HSARDAVAETVQFLALVSGSLGKLAMDISIMMTTELGEVAEPFVRHRGASSTMPQKQNPV 284 Query: 300 RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNIS 359 E + AR + L A + FER + E F A IL + + Sbjct: 285 SCELILAGARIVRNHATSMLD-AMIHDFERATGPWHLEWSAVPEGFAVASGILYQAEFML 343 Query: 360 EGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGG 419 GL V+P + + + E ++MA+ G R++ H+ + + ++A V+ + G Sbjct: 344 GGLQVFPDRMRENLDHSRGLIVAEAVMMALAPHTG-RKEAHDIVYLGCRRA---VEDKTG 399 Query: 420 DNDLIERIQVDAYFSPIHSQ-LDHLLDPSSFTGRASQQVQRFL 461 +++ + A P+ + L L DP ++ G A V L Sbjct: 400 LFEVLRTMPEVA--KPLGEEALRDLTDPRNYLGSAGAMVDNVL 440 >1RE5-A nrPDB Length = 450 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 120/451 (26%), Positives = 184/451 (40%), Gaps = 24/451 (5%) Query: 21 YASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGL-PITDEQIQEMKSNLENIDFKMAAE 79 + +P M +FSDR + + LA AE + GL P + E E D A Sbjct: 10 FTAPAMREIFSDRGRLQGMLDFEAALARAEASAGLVPHSAVAAIEAACQAERYDTGALAN 69 Query: 80 EEKRLRHDVMAHVHTFGHC----CPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKL 135 + + V G P+A +HLGATS D ++ LR+ALDL+ L Sbjct: 70 AIATAGNSAIPLVKALGKVIATGVPEAERYVHLGATSQDAMDTGLVLQLRDALDLIEADL 129 Query: 136 ARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRF 195 ++ L+ A + A P +G T Q A T+G + + L Q L+ +R L Sbjct: 130 GKLADTLSQQALKHADTPLVGRTWLQHATPVTLGMKLAGVLGALTRHRQRLQELRPRLLV 189 Query: 196 RGVKGTTGTQASF-LQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSV 254 G +G+ A+ + + EQL + E+ + R +E SV Sbjct: 190 LQFGGASGSLAALGSKAMPVAEALAEQLKLTLPEQPWHTQ----------RDRLVEFASV 239 Query: 255 LASLGASVHKICTDIRLLANLK--EMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLM 312 L + S+ K DI LL + E+ EP + GSS MP+KRNP+ + A + Sbjct: 240 LGLVAGSLGKFGRDISLLMQTEAGEVFEPSAPGKGGSSTMPHKRNPVGAAVLIGAATRVP 299 Query: 313 TLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERR 372 L + L A Q ER+L L + L Q I+EG+ V + R Sbjct: 300 GL-LSTLFAAMPQEHERSLGLWHAEWETLPDICCLVSGALRQAQVIAEGMEVDAARMRRN 358 Query: 373 IRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAY 432 + + E + + + + G R H + Q+A V +Q L + QV A Sbjct: 359 LDLTQGLVLAEAVSIVLAQRLG-RDRAHHLLEQCCQRA--VAEQRHLRAVLGDEPQVSAE 415 Query: 433 FSPIHSQLDHLLDPSSFTGRASQQVQRFLEE 463 S +LD LLDP+ + G+A V R + E Sbjct: 416 LS--GEELDRLLDPAHYLGQARVWVARAVSE 444 >2QGA-B nrPDB Length = 465 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 113/481 (23%), Positives = 199/481 (41%), Gaps = 64/481 (13%) Query: 15 SPLASRY--ASPEMCFVFSDR--YKFRTWRQL-WLWLAEAEQTLGLPITD---EQIQEMK 66 SP+ RY A E+ FS+ K R ++ WL E+ +TD E + ++ Sbjct: 9 SPIDGRYKKACGELSAFFSEHALIKHRIIVEVRWLLFLNEEELFFEKVTDHSVEVLNQIA 68 Query: 67 SNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCP--------KAAGIIHLGATSCYVGDN 118 +N+ + D E+ HDV A + K +H TS + + Sbjct: 69 TNITDSDIARVKAIEEETNHDVKAVEYFVKEKLKNSKREDLLKIKEYVHYLCTSEDINNV 128 Query: 119 TDLIILRNAL-DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQ 177 L+ L D+++P L +++ +L D A E + +P L TH QPA TT GK + Sbjct: 129 AYATCLKACLNDVVIPCLEKIMLKLKDLAVEYSHVPLLSRTHGQPASSTTFGKEMANFYA 188 Query: 178 DLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAG--FKRA 235 + + ++RV+ +F G G HKV D G K+ Sbjct: 189 RIHHHVGVIRRVKVCAKFNGAVGNFNA------------HKVASKDTDWVNTIGLFLKKH 236 Query: 236 FIITGQTYTRKVD-----IEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSS 290 F +T Y ++ E+ LA ++ +C DI L + ++ +++++GSS Sbjct: 237 FNLTYSIYCTQIQDHDYICELCDGLARANGTLIDLCVDIWLYISNNLLKLKVKEKEVGSS 296 Query: 291 AMPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSA---NRRICLAEA 344 MP+K NP+ +E +A L L T+ +Q R L DS N LA Sbjct: 297 TMPHKVNPIDFENAEGNLHIANAFFKLFSSKLPTSRLQ---RDLSDSTVLRNIGSSLAYC 353 Query: 345 FLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIR 404 + ++L L I + + +E + Q +A + +V + D +E+++ Sbjct: 354 LIAYKSVLKGLNKID----IDRRNLEEELNQNWSTLAEP---IQIVMKRHNYVDAYEELK 406 Query: 405 VLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLD--PSSFTGRA---SQQVQR 459 ++ V+ Q+ + E I+ F P +D LL+ P+++TG A ++ V+R Sbjct: 407 QFTR--GKVIDQKI----MQEFIKTKCAFLP-QDVVDQLLELTPATYTGYADYLAKNVER 459 Query: 460 F 460 Sbjct: 460 L 460 >2FEL-A nrPDB Length = 359 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 87/334 (26%), Positives = 137/334 (41%), Gaps = 51/334 (15%) Query: 17 LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKM 76 L+ + E+ +FS + + LA+AE + D++ + + S L M Sbjct: 11 LSGLFGDSEIIELFSAKADIDAMIRFETALAQAEAEASI-FADDEAEAIVSGLSEFAADM 69 Query: 77 AAEEEKRLRHDVMAHVHTFGHCCP------------KAAGIIHLGATSCYVGDNTDLIIL 124 +A LRH V G P +AA +H GATS V D + ++ L Sbjct: 70 SA-----LRHGVAKD----GVVVPELIRQMRAAVAGQAADKVHFGATSQDVIDTSLMLRL 120 Query: 125 RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQ 184 + A +++ +L +I L D A P G+T Q A TV R WI L L Sbjct: 121 KMAAEIIATRLGHLIDTLGDLASRDGHKPLTGYTRMQAAIGITVADRAAGWIAPLERHLL 180 Query: 185 NLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIIT----- 239 L+ T Q F F G +E+L + AG RA + Sbjct: 181 RLE--------------TFAQNGFALQFGGAAGTLEKLG----DNAGAVRADLAKRLGLA 222 Query: 240 --GQTYTRKVDI-EVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKR 296 Q + ++ I E ++L+ + ++ K DI L+A + E GSSAMP+K+ Sbjct: 223 DRPQWHNQRDGIAEFANLLSLVTGTLGKFGQDIALMAEIG--SEIRLSGGGGSSAMPHKQ 280 Query: 297 NPMRSERCCSLARHLMTLVMDPLQTASVQWFERT 330 NP+ +E +LAR + + L + VQ ER+ Sbjct: 281 NPVNAETLVTLAR-FNAVQISALHQSLVQEQERS 313 >4EFC-A nrPDB Length = 472 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 110/444 (24%), Positives = 184/444 (41%), Gaps = 74/444 (16%) Query: 15 SPLASRYASPEMCF-VFSDRYKFRTWRQLWLWLAEAEQTLGL-----------PITDEQI 62 SPL RY F Y F +R L E E L +TDEQ+ Sbjct: 25 SPLDGRYKRQTKALRAFFSEYGFFRYRVL----VEVEYFTALCKDVPTIVPLRSVTDEQL 80 Query: 63 QEMKSNLENIDFKMAAEEEKRL----RHDVMAHVHTFGHCCPKAAGI------IHLGATS 112 Q+++ + +AEE KRL HD+ A V F G+ +H G TS Sbjct: 81 QKLRKITLDCFSVSSAEEIKRLERVTNHDIKA-VEYFIKERMDTCGLSHVTEFVHFGLTS 139 Query: 113 CYVGDNTDLIILRNAL-DLLLPKLARVI----SRLADFAKERASLPTLGFTHFQPAQLTT 167 + + +++R+A+ L LP L +I S+L D+ +P L TH QPA T Sbjct: 140 QDINNTAIPMMIRDAIVTLYLPALDGIIGSLTSKLVDW-----DVPMLARTHGQPASPTN 194 Query: 168 VGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVT 227 + K +WI+ L + L V +F G TG + L + + + D + Sbjct: 195 LAKEFVVWIERLREQRRQLCEVPTTGKF---GGATGNFNAHLVAYPSVNWRAFA-DMFLA 250 Query: 228 EKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKI----CTDIRLLANLKEMEEPFE 283 + G KR Q T+ + + L+ L A +H I C D+ ++ ++ + Sbjct: 251 KYLGLKRQ-----QATTQIENYDHLAALCDACARLHVILIDMCRDVWQYISMGFFKQKVK 305 Query: 284 KQQIGSSAMPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSA---NR 337 + ++GSS MP+K NP+ +E +L+ L+ L + +Q R L DS N Sbjct: 306 EGEVGSSTMPHKVNPIDFENAEGNLALSNALLNFFASKLPISRLQ---RDLTDSTVLRNL 362 Query: 338 RICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQ 397 + + A + +I L E L++ + I R + +A E I + R+ Sbjct: 363 GVPIGHACVAFASISQGL----EKLMISRETISRELSSNWAVVA-EGIQTVL------RR 411 Query: 398 DC----HEKIRVLSQQAASVVKQE 417 +C +E ++ L+Q V +++ Sbjct: 412 ECYPKPYETLKKLTQGNTDVTEEQ 435 >4MX2-A nrPDB Length = 480 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 85/324 (26%), Positives = 143/324 (44%), Gaps = 44/324 (13%) Query: 9 SPDSYRSPLASRY---ASPEMCFVFSDR--YKFRTWRQLWLWLAEAEQTLGLP----ITD 59 SP SPL RY +P + FS+ +K+R ++ + A ++ + +TD Sbjct: 30 SPLYSLSPLDGRYKRDTTPLRAY-FSEYALFKYRVQVEVLYFEALCKEVPAITQLRGVTD 88 Query: 60 EQIQEMK-SNLENI---DFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGI------IHLG 109 Q+ E++ + EN D K+ E HD+ A V + A G+ IH G Sbjct: 89 AQLGELRATTFENFAVDDAKIIKGIEAVTNHDIKA-VEYYLKDKMSACGLEAEKEFIHFG 147 Query: 110 ATSCYVGDNTDLIILRNALDL-LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTV 168 TS + + + ++LR+AL +P L ++I+ L E +P L TH QPA T + Sbjct: 148 LTSQDINNTSIPMLLRDALHHHYIPTLDQLIALLKSKLPEW-DVPMLARTHGQPASPTNL 206 Query: 169 GKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLD---KM 225 K +WI+ L L + + +F G TG + L + G V LD Sbjct: 207 AKEFMVWIERLEEQRTMLLSIPNTGKF---GGATGNFNAHLCAYPG----VNWLDFGELF 259 Query: 226 VTEKAGFKRAFIITGQTYTRKVD-IEVLSVLASLGASVHKI----CTDIRLLANLKEMEE 280 +++ G +R Q YT +++ + L+ + A +H I D+ +L ++ Sbjct: 260 LSKYLGLRR------QRYTTQIEHYDNLAAICDACARLHTILMDLAKDVWQYISLGYFDQ 313 Query: 281 PFEKQQIGSSAMPYKRNPMRSERC 304 ++GSSAMP+K NP+ E Sbjct: 314 KVRAGEVGSSAMPHKVNPIDFENA 337 >5XNZ-A nrPDB Length = 489 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 63/207 (30%), Positives = 94/207 (45%), Gaps = 8/207 (3%) Query: 100 PKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTH 159 P AA +H G+TS V D +++ R AL L+ L R LA A + P G T Sbjct: 124 PAAAEYVHRGSTSQDVLDTGAMLVARRALRLIGDDLDRAADALAALAADHRDTPMAGRTL 183 Query: 160 FQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKV 219 A TT G + W++ + + R+RD L F + G GT A + Sbjct: 184 ALHAVPTTFGLKAAGWLELVSEAAGRVARLRDGLPF-SLGGAAGTLAGYFGDRTDRGDPA 242 Query: 220 EQLDKMVTEKA---GFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLA--N 274 LD+++ A G R + T D+ +VLA ++ KI D++ LA Sbjct: 243 VLLDRLLDAYAAETGLARPVLPWHVLRTPVADLA--AVLAFTAGALGKIAVDVQSLARTE 300 Query: 275 LKEMEEPFEKQQIGSSAMPYKRNPMRS 301 + E+ EP + + SSAMP+KRNP+ S Sbjct: 301 VAEVAEPAVEGRGASSAMPHKRNPVLS 327 >3BHG-A nrPDB Length = 459 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 73/345 (21%), Positives = 131/345 (37%), Gaps = 39/345 (11%) Query: 15 SPLASRYA------SPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQ----IQE 64 SP+ RY SP Y+ + + LA + +P D + + + Sbjct: 13 SPIDGRYVNKTRALSPYFSEFALTYYRLMVEIKWFESLAANDTIPEVPALDNKARKFLSD 72 Query: 65 MKSNLENIDFKMAAEEEKRLRHDVMAHVHTF------GHCCPKAAGIIHLGATSCYVGDN 118 + SN + + E EK+ HDV A + IH TS + + Sbjct: 73 LISNFNESEAEKIKEFEKQTNHDVKAVEYYLQDKFQENEQLKSCVAFIHFACTSEDINNL 132 Query: 119 TDLIILRNAL-DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQ 177 ++++ A+ ++ P +A ++ + K+ A + L TH QPA TT+GK ++ Sbjct: 133 AYALMIKQAIAQVIQPTIAEIMGSITLLGKQHADVAMLSRTHGQPATPTTMGKELVNFVA 192 Query: 178 DLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFI 237 L Q L V +F G G + + H A F + Sbjct: 193 RLKRPQQQLAEVLIPAKFNGAVGNYNAHVAAYPEVDWRKH-----------CANFVTSLG 241 Query: 238 ITGQTYTRKVD-----IEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAM 292 ++ YT +++ EV ++ + + DI +L ++ +++GSS M Sbjct: 242 LSFNAYTTQIEPHDGIAEVSQIMVRINNILLDYTQDIWSYISLGYFKQKTIAEEVGSSTM 301 Query: 293 PYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDS 334 P+K NP+ +E L+ L + L + +Q R L DS Sbjct: 302 PHKVNPIDFENAEGNLGLSNALFIHFANKLTQSRMQ---RDLSDS 343 >5E3V-A nrPDB Length = 380 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 56/241 (23%), Positives = 103/241 (42%), Gaps = 27/241 (11%) Query: 105 IIHLGATSCYVGDNTDLIILRNALD-LLLPKLARVISRLADFAKERASLPTLGFTHFQPA 163 IH TS + + + ++L+ A D ++LP +VI+ + D A + +P L TH QPA Sbjct: 130 FIHFACTSEDINNLSHALMLKTARDEVILPYWRQVINAVKDLATQYRDIPLLSRTHGQPA 189 Query: 164 QLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRG-VKGTTGTQASFLQLF-EGDDHKVEQ 221 +T+GK ++ ++ R + + G + G G + + + E D H+ + Sbjct: 190 TPSTLGKEMA----NVAYRMERQFRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSE 245 Query: 222 LDKMVTEKAGFKRAFIITGQTYTRKVD-----IEVLSVLASLGASVHKICTDIRLLANLK 276 F + I YT +++ E+ +A + D+ L Sbjct: 246 ---------EFVTSLGIQWNPYTTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALN 296 Query: 277 EMEEPFEKQQIGSSAMPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDD 333 ++ +IGSS MP+K NP+ SE L+ ++ + + L V ++R L D Sbjct: 297 HFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLSNAVLHHLANKL---PVSRWQRDLTD 353 Query: 334 S 334 S Sbjct: 354 S 354 >4NSL-A nrPDB Length = 470 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 56/241 (23%), Positives = 103/241 (42%), Gaps = 27/241 (11%) Query: 105 IIHLGATSCYVGDNTDLIILRNALD-LLLPKLARVISRLADFAKERASLPTLGFTHFQPA 163 IH TS + + + ++L+ A D ++LP +VI+ + D A + +P L TH QPA Sbjct: 130 FIHFACTSEDINNLSHALMLKTARDEVILPYWRQVINAVKDLATQYRDIPLLSRTHGQPA 189 Query: 164 QLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRG-VKGTTGTQASFLQLF-EGDDHKVEQ 221 +T+GK ++ ++ R + + G + G G + + + E D H+ + Sbjct: 190 TPSTLGKEMA----NVAYRMERQFRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSE 245 Query: 222 LDKMVTEKAGFKRAFIITGQTYTRKVD-----IEVLSVLASLGASVHKICTDIRLLANLK 276 F + I YT +++ E+ +A + D+ L Sbjct: 246 ---------EFVTSLGIQWNPYTTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALN 296 Query: 277 EMEEPFEKQQIGSSAMPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDD 333 ++ +IGSS MP+K NP+ SE L+ ++ + + L V ++R L D Sbjct: 297 HFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLSNAVLHHLANKL---PVSRWQRDLTD 353 Query: 334 S 334 S Sbjct: 354 S 354 >2PTS-A nrPDB Length = 462 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 56/240 (23%), Positives = 101/240 (42%), Gaps = 27/240 (11%) Query: 106 IHLGATSCYVGDNTDLIILRNALD-LLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ 164 IH TS + + + ++L+ A D ++LP ++I L D A + +P L TH QPA Sbjct: 117 IHFACTSEDINNLSHALMLKTARDEVILPYWRQLIDGLKDLAVQYRDIPLLSRTHGQPAT 176 Query: 165 LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRG-VKGTTGTQASFLQLF-EGDDHKVEQL 222 +T+GK ++ ++ R + + G + G G + + + E D H+ + Sbjct: 177 PSTIGKEMA----NVAYRMERQYRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSE- 231 Query: 223 DKMVTEKAGFKRAFIITGQTYTRKVD-----IEVLSVLASLGASVHKICTDIRLLANLKE 277 F + I YT +++ E+ +A + D+ L Sbjct: 232 --------EFVTSLGIQWNPYTTQIEPHDYIAELFDCVARFNTILIDFDRDVWGYIALNH 283 Query: 278 MEEPFEKQQIGSSAMPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDS 334 ++ +IGSS MP+K NP+ SE L+ ++ + L V ++R L DS Sbjct: 284 FKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLSNAVLQHLASKL---PVSRWQRDLTDS 340 >1YFM-A nrPDB Length = 488 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 12/188 (6%) Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 L+P+L + + L +KE + +G TH Q A T+G+ ++Q + +Q + Sbjct: 185 LIPELTNLKNALEAKSKEFDHIVKIGRTHLQDATPLTLGQEFSGYVQQVENGIQRVAHSL 244 Query: 191 DDLRFRGVKGTTGTQASFLQLFEGDDHKV-EQLDKMVTEKAGFKRAFIITGQTYTRKVDI 249 L F GT + L G D K+ EQ+ K K F+ A + Sbjct: 245 KTLSFLAQGGT--AVGTGLNTKPGFDVKIAEQISKETGLK--FQTAPNRFEALAAHDAIV 300 Query: 250 EVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMRSERC 304 E L +L S+ KI DIR L + E+ P + + GSS MP K NP ++E Sbjct: 301 ECSGALNTLACSLFKIAQDIRYLGSGPRCGYHELMLP--ENEPGSSIMPGKVNPTQNEAL 358 Query: 305 CSLARHLM 312 + +M Sbjct: 359 TQVCVQVM 366 >1FUP-A nrPDB Length = 472 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 50/191 (26%), Positives = 77/191 (40%), Gaps = 24/191 (12%) Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 L+P+L + L + ++ A + +G TH Q A T+G+ W+ M NLK + Sbjct: 160 LIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWV---AMLEHNLKHIE 216 Query: 191 DDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQT-----YTR 245 L GT G + E ++ E A A +T T Sbjct: 217 YSLPHVAELALGGTAVG-----TGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATC 271 Query: 246 KVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMR 300 ++ L L AS+ KI D+R LA+ + E+ P + + GSS MP K NP + Sbjct: 272 DALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIP--ENEPGSSIMPGKVNPTQ 329 Query: 301 SER----CCSL 307 E CC + Sbjct: 330 CEALTMLCCQV 340 >3GTD-A nrPDB Length = 482 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 50/188 (26%), Positives = 81/188 (43%), Gaps = 12/188 (6%) Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 L+P L +++ L D +K+ + +G TH Q A T+ + +I + L+ R+ Sbjct: 181 LIPALNNLLTYLQDKSKDWDKIIKIGRTHLQDATPLTLKQEFSGYITQIEYALE---RIE 237 Query: 191 DDLRFRGVKGTTGTQ-ASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDI 249 D L+ + GT + + G D K Q T++ FK A + Sbjct: 238 DALKKVYLLAQGGTAVGTGINSKIGFDIKFAQKVAEFTQQP-FKTAPNKFESLAAHDALV 296 Query: 250 EVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMRSERC 304 E L ++ S+ KI DIRLL + L E+ P + + GSS MP K NP + E Sbjct: 297 EFSGTLNTIAVSLMKIANDIRLLGSGPRCGLGELHLP--ENEPGSSIMPGKVNPTQVEAL 354 Query: 305 CSLARHLM 312 + +M Sbjct: 355 TMVCTQVM 362 >3RRP-A nrPDB Length = 471 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 84/211 (39%), Gaps = 22/211 (10%) Query: 107 HLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLT 166 HL AT V D L+P L + LA AK ++ G TH A Sbjct: 151 HLAATEAAVRD-------------LIPALEYLQQALATKAKAWKTVVKSGRTHLMDAVPV 197 Query: 167 TVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMV 226 T+G+ + + + ++ +K L + GT + L +G KV ++ K Sbjct: 198 TLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTA--VGTGLNAPDGFGAKVVEVLKQS 255 Query: 227 TEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRL-----LANLKEMEEP 281 T + K A R +E L ++ AS+ KI DIR L L E++ P Sbjct: 256 TGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIANDIRWMGSGPLTGLGEIQLP 315 Query: 282 FEKQQIGSSAMPYKRNPMRSERCCSLARHLM 312 Q GSS MP K NP+ E +A ++ Sbjct: 316 --DLQPGSSIMPGKVNPVLPEAVTQVAAQVI 344 >5UPP-A nrPDB Length = 466 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 113/292 (38%), Gaps = 20/292 (6%) Query: 129 DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKR 188 ++LLP L ++ L +KE A + +G TH Q A T+G+ ++Q + + +K Sbjct: 161 EVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKA 220 Query: 189 VRDDLRFRGVKGT---TG--TQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTY 243 + GT TG T+ F + + L VT F+ Sbjct: 221 AMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGL-PFVTAPNKFE-------ALA 272 Query: 244 TRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNP 298 +E+ + + S+ KI DIR L + L E+ P + + GSS MP K NP Sbjct: 273 AHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILP--ENEPGSSIMPGKVNP 330 Query: 299 MRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNI 358 + E +A +M + S FE + + L A L D ++ +N Sbjct: 331 TQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENC 390 Query: 359 SEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQA 410 G+ + I + + + L + N + KA + H+ L + A Sbjct: 391 VVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETA 442 >3TV2-A nrPDB Length = 459 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 52/195 (26%), Positives = 82/195 (42%), Gaps = 20/195 (10%) Query: 125 RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQ 184 R +D LLP L + + L A A + +G TH Q A T+G+ ++ L ++ Sbjct: 150 RAIVDHLLPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIR 209 Query: 185 NLKRVRDDLRFRGVKGT---TGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQ 241 +++ L GT TG A + G ++ +L + A K + Sbjct: 210 HVEAALPHLYELAQGGTAVGTGLNA-HPKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAAD 268 Query: 242 TYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKR 296 + L ++ AS+ KI DIR LA+ L E+ P + + GSS MP K Sbjct: 269 AL-----VFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIP--ENEPGSSIMPGKV 321 Query: 297 NPMRSER----CCSL 307 NP +SE CC + Sbjct: 322 NPTQSEAVTMLCCQV 336 >3RD8-A nrPDB Length = 489 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/183 (26%), Positives = 76/183 (41%), Gaps = 9/183 (4%) Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 L+P L + + LA AK+ ++ G TH A T+G+ + + + ++ +K Sbjct: 178 LIPALEVLHASLAAKAKQWRTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATL 237 Query: 191 DDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIE 250 L + GT + L EG KV ++ T A + A R +E Sbjct: 238 PRLGELAIGGT--AVGTGLNAPEGFGAKVVEVLVNETGLAELRTAVDSFEAQAARDGLVE 295 Query: 251 VLSVLASLGASVHKICTDIRL-----LANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCC 305 L ++ S+ KI DIR L L E++ P Q GSS MP K NP+ E Sbjct: 296 ASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLP--DLQPGSSIMPGKVNPVLPEAVT 353 Query: 306 SLA 308 +A Sbjct: 354 QVA 356 >3QBP-A nrPDB Length = 478 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 81/206 (39%), Gaps = 17/206 (8%) Query: 127 ALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNL 186 A+ L+P L + LA A E S+ G TH A T+G+ + + + + Sbjct: 164 AVSHLIPALEILQDALATKALEWQSVVKSGRTHLMDAVPVTLGQEFSGYARQIEA---GI 220 Query: 187 KRVRDDLRFRGVKGTTGTQ-ASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTR 245 +RVR L G GT + L EG KV + T + A R Sbjct: 221 ERVRATLPRLGELAIGGTAVGTGLNAPEGFGVKVVSVLVSQTGLPQLRTAANSFEAQAAR 280 Query: 246 KVDIEVLSVLASLGASVHKICTDIRL-----LANLKEMEEPFEKQQIGSSAMPYKRNPMR 300 +E L ++ S+ KI DIR L L E++ P Q GSS MP K NP+ Sbjct: 281 DGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLP--DLQPGSSIMPGKVNPVL 338 Query: 301 SERCCSLARHLMTLVMDPLQTASVQW 326 E +A ++ A+V W Sbjct: 339 PEAVTQVAAQVIG------NDAAVAW 358 >1VDK-A nrPDB Length = 466 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 45/180 (25%), Positives = 72/180 (40%), Gaps = 16/180 (8%) Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 L P + +I A+ + +G TH A T+G+ W L L +K + Sbjct: 160 LYPAVEGLIRTFTAKAQAFDQIVKVGRTHLMDAVPITLGQEIGSWAAQLKTTLAAVKEME 219 Query: 191 DDLRFRGVKGT-TGTQASFLQLFEGDDHKVEQLDKMVTEKAG--FKRAFIITGQTYTRKV 247 L + GT GT + F E + K + E+ G F+ A Sbjct: 220 KGLYNLAIGGTAVGTGLNAHPRFG------ELVAKYLAEETGLPFRVAENRFAALAAHDE 273 Query: 248 DIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMRSE 302 + V+ + +L ++ KI D+R LA+ + E+ P + GSS MP K NP + E Sbjct: 274 LVNVMGAIRTLAGALMKIGNDVRWLASGPYAGIGEITIP--ANEPGSSIMPGKVNPTQVE 331 >3R6Q-A nrPDB Length = 468 Score = 37.0 bits (84), Expect = 0.022, Method: Compositional matrix adjust. Identities = 44/173 (25%), Positives = 74/173 (42%), Gaps = 20/173 (11%) Query: 146 AKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGT---T 202 A E A + +G TH Q A +G+ + + + D++ + R++L + T T Sbjct: 175 ADEFAGVIKMGRTHLQDAVPILLGQEFEAYARVIARDIERIANTRNNLYDINMGATAVGT 234 Query: 203 GTQASFLQLFEGDDHKVEQLDKMVTEKAG--FKRAFIITGQTYTRKVDIEVLSVLASLGA 260 G A D + + + + + +G + A + T EV S L Sbjct: 235 GLNA--------DPEYISIVTEHLAKFSGHPLRSAQHLVDATQNTDCYTEVSSALKVCMI 286 Query: 261 SVHKICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLA 308 ++ KI D+RL+A+ L E+ P +Q GSS MP K NP+ E +A Sbjct: 287 NMSKIANDLRLMASGPRAGLSEIVLP--ARQPGSSIMPGKVNPVMPEVMNQVA 337 >4ADL-A nrPDB Length = 495 Score = 35.4 bits (80), Expect = 0.057, Method: Compositional matrix adjust. Identities = 50/189 (26%), Positives = 78/189 (41%), Gaps = 13/189 (6%) Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 L+P L ++ LA A + ++ G TH A T+G+ + + + ++RVR Sbjct: 181 LIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEA---GIERVR 237 Query: 191 DDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEK--AGFKRAFIITGQTYTRKVD 248 L G GT A L DD V + +V + + + A R Sbjct: 238 ACLPRLGELAIGGT-AVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGL 296 Query: 249 IEVLSVLASLGASVHKICTDIRL-----LANLKEMEEPFEKQQIGSSAMPYKRNPMRSER 303 +E L ++ S+ KI DIR L L E++ P Q GSS MP K NP+ E Sbjct: 297 VEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLP--DLQPGSSIMPGKVNPVLPEA 354 Query: 304 CCSLARHLM 312 +A ++ Sbjct: 355 VTQVAAQVI 363 >3OCE-A nrPDB Length = 474 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 44/176 (25%), Positives = 74/176 (42%), Gaps = 16/176 (9%) Query: 135 LARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLR 194 L R+I+ +E A++ +G T Q A T+G+ + L D L+ V R Sbjct: 167 LHRLIAAFEAKGREFATVIKIGRTQLQDAVPITLGQEFEAFAATLREDTARLEEVAALFR 226 Query: 195 FRGVKGTT-GTQASFLQLFEGDDHKVEQLDKMVTEKAG--FKRAFIITGQTYTRKVDIEV 251 + GT GT+ + + EQ +++ +G K + ++ + Sbjct: 227 EVNLGGTAIGTRINASHAY------AEQAIVELSQISGIELKATGNLVEASWDTGAFVTF 280 Query: 252 LSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMRSE 302 +L + + KI D+RLL++ L E+ P Q GSS MP K NP+ E Sbjct: 281 SGILRRIAVKLSKIANDLRLLSSGPRSGLGEIRLP--AVQPGSSIMPGKVNPVIPE 334 >6N1M-A nrPDB Length = 472 Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 65/158 (41%), Gaps = 20/158 (12%) Query: 155 LGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGT-TGTQASFLQLFE 213 +G TH Q A T+G+ ++ L + L+ V +L GT GT + F Sbjct: 192 IGRTHLQDAVPLTLGQEFSGYVAQLDACVHRLEEVLPELYELAAGGTAVGTGLNTHPQFA 251 Query: 214 GDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVL----SVLASLGASVHKICTDI 269 KV + +T K F+ + E L + +L ++ KI DI Sbjct: 252 V---KVAEHIAKIT-----KLPFVTAPNKFAALASHEPLVHAHGAMKTLACALMKIANDI 303 Query: 270 RLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMRSE 302 R LA+ + E+ P + + GSS MP K NP + E Sbjct: 304 RWLASGPRCGIGELIIP--ENEPGSSIMPGKVNPTQCE 339 >4HGV-A nrPDB Length = 495 Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 74/188 (39%), Gaps = 32/188 (17%) Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 LLP L + L + K + +G TH Q A T+G+ + + ++ ++ Sbjct: 192 LLPALKHLHKALEEKVKAFDHIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTL 251 Query: 191 DDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVD-I 249 L GT + G + V +K+ E A ITG +T + Sbjct: 252 PGLCELAQGGTA--------VGTGLNAPVGFAEKVAEEIAA------ITGIGFTSAPNKF 297 Query: 250 EVLSVLASL----------GASVHKICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPY 294 E L+ S+ A++ KI DIR L + L E+ P + + GSS MP Sbjct: 298 EALAAHDSMVFSHGAINATAAALFKIANDIRFLGSGPRSGLGELSLP--ENEPGSSIMPG 355 Query: 295 KRNPMRSE 302 K NP + E Sbjct: 356 KVNPTQCE 363 >4HOQ-A nrPDB Length = 482 Score = 32.0 bits (71), Expect = 0.57, Method: Compositional matrix adjust. Identities = 22/109 (20%), Positives = 48/109 (44%), Gaps = 10/109 (9%) Query: 369 IERRIRQELPFMATE------NIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDND 422 +E I Q+L F+ T+ N++ + G +D E + +QA +++QE D + Sbjct: 34 VEDTIGQQLEFLTTKSRLALYNLLAYVKHLKGQNKDALECL----EQAEEIIQQEHSDKE 89 Query: 423 LIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKP 471 + + ++ ++ +D L + +TG+ ++ Y L P Sbjct: 90 EVRSLVTWGNYAWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSNYKLECP 138 >1JSW-A nrPDB Length = 478 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 21/52 (40%), Positives = 26/52 (50%), Gaps = 7/52 (13%) Query: 249 IEVLSVLASLGASVHKICTDIRLL-----ANLKEMEEPFEKQQIGSSAMPYK 295 + V L L + KIC D+RLL A L E+ P + Q GSS MP K Sbjct: 278 VMVHGALKRLAVKMSKICNDLRLLSSGPRAGLNEINLP--ELQAGSSIMPAK 327 >6BAC-A nrPDB Length = 379 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 8/83 (9%) Query: 386 IMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQL-DHLL 444 +M M G + D E ++ QAAS G ++ E I + IH+Q+ D L Sbjct: 147 LMLMALGGLFQNDLVEWATSMTYQAAS----GAGAKNMRELI---SGMGAIHAQVADELA 199 Query: 445 DPSSFTGRASQQVQRFLEEEVYP 467 DPSS ++V FL E YP Sbjct: 200 DPSSAILDIDRKVSDFLRSEDYP 222 >2OBA-A nrPDB Length = 138 Score = 30.4 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 2/50 (4%) Query: 428 QVDAYFSPIHSQLDH--LLDPSSFTGRASQQVQRFLEEEVYPLLKPYESV 475 ++ A F PI+ QLDH L D S+ + R++ +++ PLL V Sbjct: 74 EIKAIFKPIYEQLDHNYLNDIPGLENPTSENLCRWIWQQLKPLLPELSKV 123 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2J91-A nrPDB 674 0.0 5V4L-A nrPDB 599 e-171 5VKW-A nrPDB 579 e-165 5EYT-A nrPDB 561 e-160 1YIS-A nrPDB 482 e-136 1F1O-A nrPDB 446 e-125 2PFM-A nrPDB 446 e-125 2X75-A nrPDB 444 e-125 4NLE-A nrPDB 429 e-120 1C3C-A nrPDB 428 e-120 1RE5-A nrPDB 380 e-106 3C8T-A nrPDB 379 e-105 1Q5N-A nrPDB 377 e-105 4EEI-A nrPDB 368 e-102 2QGA-B nrPDB 348 4e-96 4EFC-A nrPDB 326 1e-89 1DOF-A nrPDB 323 1e-88 4MX2-A nrPDB 310 7e-85 3BHG-A nrPDB 305 3e-83 4NSL-A nrPDB 299 2e-81 2PTS-A nrPDB 296 2e-80 5E3V-A nrPDB 274 5e-74 5UPP-A nrPDB 257 1e-68 5XNZ-A nrPDB 256 1e-68 2FEL-A nrPDB 249 2e-66 3GTD-A nrPDB 233 1e-61 1YFM-A nrPDB 233 2e-61 3TV2-A nrPDB 225 5e-59 1FUP-A nrPDB 220 9e-58 3RD8-A nrPDB 215 5e-56 3RRP-A nrPDB 210 8e-55 Sequences not found previously or not previously below threshold: 4HGV-A nrPDB 217 7e-57 3QBP-A nrPDB 208 5e-54 4ADL-A nrPDB 205 4e-53 6N1M-A nrPDB 204 5e-53 1VDK-A nrPDB 176 1e-44 3R6Q-A nrPDB 161 6e-40 3OCE-A nrPDB 152 2e-37 1JSW-A nrPDB 121 7e-28 1TJU-A nrPDB 117 7e-27 1TJ7-A nrPDB 110 1e-24 2E9F-A nrPDB 107 1e-23 1I0A-A nrPDB 105 5e-23 6G3D-A nrPDB 99 3e-21 1AOS-A nrPDB 97 1e-20 6IG5-A nrPDB 78 9e-15 3H2Z-A nrPDB 37 0.013 1GFN-A nrPDB 33 0.33 4YWO-A nrPDB 32 0.84 1H2B-A nrPDB 31 1.1 4UEJ-A nrPDB 31 1.5 5Z3D-A nrPDB 30 2.6 1XKW-A nrPDB 29 3.5 6B2E-B nrPDB 29 4.1 5VFB-A nrPDB 29 4.1 4IMM-A nrPDB 29 4.1 3ORP-A nrPDB 29 6.3 3BJE-A nrPDB 29 7.0 >2J91-A nrPDB Length = 503 Score = 674 bits (1739), Expect = 0.0, Method: Composition-based stats. Identities = 480/481 (99%), Positives = 481/481 (100%) Query: 1 MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE 60 MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE Sbjct: 23 MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE 82 Query: 61 QIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD 120 QI+EMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD Sbjct: 83 QIREMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD 142 Query: 121 LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC 180 LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC Sbjct: 143 LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC 202 Query: 181 MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG 240 MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG Sbjct: 203 MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG 262 Query: 241 QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR 300 QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR Sbjct: 263 QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR 322 Query: 301 SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE 360 SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE Sbjct: 323 SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE 382 Query: 361 GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD 420 GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD Sbjct: 383 GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD 442 Query: 421 NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA 480 NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA Sbjct: 443 NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA 502 Query: 481 E 481 E Sbjct: 503 E 503 >5V4L-A nrPDB Length = 479 Score = 599 bits (1543), Expect = e-171, Method: Composition-based stats. Identities = 333/469 (71%), Positives = 382/469 (81%), Gaps = 2/469 (0%) Query: 11 DSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLE 70 DSY++PL+SRYAS EM +FS +F TWR+LWL LA AE+ LGL I+D I++MK+NLE Sbjct: 2 DSYQTPLSSRYASKEMSKLFSSGARFGTWRKLWLNLAIAEKELGLAISDAAIEQMKANLE 61 Query: 71 --NIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNAL 128 K+AAEEEK+ RHDVMAHVHTFG P+AAGIIHLGATSCYV DN DLI LR+ L Sbjct: 62 LDEAQMKVAAEEEKKRRHDVMAHVHTFGTVAPEAAGIIHLGATSCYVTDNADLIFLRDGL 121 Query: 129 DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKR 188 D+LLPKLA VISRLA+FAK+ LPTLGFTHFQPAQLTTVGKR LWIQ+L DL+NL+R Sbjct: 122 DILLPKLATVISRLANFAKQYRDLPTLGFTHFQPAQLTTVGKRATLWIQELLWDLRNLQR 181 Query: 189 VRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVD 248 RDDL FRGVKGTTGTQASFL LF+GD KVE LDK VTE GF A+ +TGQTY+RK+D Sbjct: 182 ARDDLGFRGVKGTTGTQASFLALFDGDHAKVEALDKRVTELFGFPYAYPVTGQTYSRKID 241 Query: 249 IEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLA 308 +VL L+S GA+VHKI TDIRLLANLKE+EEPFEK QIGSSAM YKRNPMR ER CSLA Sbjct: 242 ADVLGPLSSFGATVHKIATDIRLLANLKEIEEPFEKDQIGSSAMAYKRNPMRCERACSLA 301 Query: 309 RHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKV 368 RHLM + + L T+SVQW ERTLDDSANRR+ + EAFLTAD +L TLQNISEGLVVYP+V Sbjct: 302 RHLMAIYQNTLMTSSVQWLERTLDDSANRRVTIPEAFLTADILLTTLQNISEGLVVYPRV 361 Query: 369 IERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQ 428 I RRI QELPFMATENIIMA+VKAGG RQ+CHEKIRVLS QA +VVK+EGG+NDLI+R++ Sbjct: 362 IGRRISQELPFMATENIIMAIVKAGGDRQECHEKIRVLSHQAGAVVKEEGGENDLIDRVK 421 Query: 429 VDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMK 477 D YF PI QLD LLDP +F GRA +QV FL+E V P LKPYE +K Sbjct: 422 NDEYFKPIWGQLDALLDPRTFVGRAPEQVDGFLKEWVEPALKPYEEALK 470 >5VKW-A nrPDB Length = 482 Score = 579 bits (1491), Expect = e-165, Method: Composition-based stats. Identities = 313/466 (67%), Positives = 366/466 (78%), Gaps = 3/466 (0%) Query: 11 DSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPI-TDEQIQEMKSNL 69 D Y +PL+SRYAS EM +FS R +F TWR+LWL LA AE+ +GL + TDE I++MK +L Sbjct: 5 DKYSTPLSSRYASEEMSKIFSLRNRFSTWRKLWLNLAIAEKEVGLSVITDEAIEQMKQHL 64 Query: 70 ENIDFKM--AAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNA 127 E D ++ AA EE ++RHDVMAHVH FG CP AAGIIHLGATSC+V DN DLI LR+A Sbjct: 65 EITDKEIQDAAVEEAKVRHDVMAHVHVFGETCPSAAGIIHLGATSCFVTDNADLIFLRDA 124 Query: 128 LDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLK 187 D+L+PKL VI RL+ FA E LP LG+THFQPAQLTTVGKR LW+Q+L DL+N+ Sbjct: 125 YDVLIPKLVNVIDRLSKFALEYKDLPVLGWTHFQPAQLTTVGKRATLWLQELLWDLRNMV 184 Query: 188 RVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKV 247 R R+D+ RGVKGTTGTQASFL LF GD KVE+LDK V E GF + +TGQTY+RK+ Sbjct: 185 RARNDIGLRGVKGTTGTQASFLSLFHGDHDKVEELDKRVVELLGFDIVYPVTGQTYSRKI 244 Query: 248 DIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSL 307 DI+VLS LAS GA+ HK TDIRLLANLKE+EEPFEK QIGSSAM YKRNPMR ER CSL Sbjct: 245 DIDVLSPLASFGATAHKFATDIRLLANLKEIEEPFEKSQIGSSAMAYKRNPMRCERVCSL 304 Query: 308 ARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPK 367 ARHL L D +QTASVQWFERTLDDSA RRI L AFLT D +L+T+ NI+ GLVVYPK Sbjct: 305 ARHLGGLFNDAVQTASVQWFERTLDDSAIRRISLPSAFLTVDILLSTMLNITSGLVVYPK 364 Query: 368 VIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERI 427 VIERRI ELPFMATENIIMAMV+ GGSRQDCHE+IRVLS QA++VVKQEGGDNDLIERI Sbjct: 365 VIERRINSELPFMATENIIMAMVEKGGSRQDCHEEIRVLSHQASAVVKQEGGDNDLIERI 424 Query: 428 QVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYE 473 + YF PI + LD LLDP +F GRA QQ ++F++ +V LKP+E Sbjct: 425 KSTEYFKPIWNDLDTLLDPKTFVGRAPQQTEKFVKNDVANALKPFE 470 >5EYT-A nrPDB Length = 497 Score = 561 bits (1445), Expect = e-160, Method: Composition-based stats. Identities = 268/476 (56%), Positives = 353/476 (74%), Gaps = 2/476 (0%) Query: 11 DSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLE 70 + YR+PL RYAS EM F ++ K WRQLW+WLAE ++ LG ITDEQI EMKS + Sbjct: 22 EEYRNPLTKRYASREMVCNFGEKRKVILWRQLWIWLAETQKELGFDITDEQINEMKSQRD 81 Query: 71 NIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDL 130 ++DF AA EEK RHDVMAHV+TF CPKAA IIHLGATSC+VGDN DLI+L++ L++ Sbjct: 82 SVDFGTAAAEEKARRHDVMAHVYTFALACPKAAPIIHLGATSCFVGDNADLIMLKDGLNI 141 Query: 131 LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVR 190 LLPK+AR I RLA A SL L TH QPAQ TT+G+R C+WIQDL +DL+NL+R++ Sbjct: 142 LLPKVARCIDRLAKKAMLHKSLICLARTHLQPAQPTTMGRRICMWIQDLLLDLENLERLK 201 Query: 191 DD-LRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDI 249 + +RFRG KG GTQASF+ LF+GD KV +LD+++T+K+GF+R++ +TGQTY RKVDI Sbjct: 202 NHTIRFRGAKGAVGTQASFMDLFQGDHQKVIKLDEILTKKSGFQRSWCVTGQTYPRKVDI 261 Query: 250 EVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLAR 309 E+ + L+++GA+VHKICTDIRLL++ E+EEPFE +QIGSSAMPYKRNP+RSER CSLAR Sbjct: 262 EITNALSNIGATVHKICTDIRLLSSFHEVEEPFETKQIGSSAMPYKRNPIRSERACSLAR 321 Query: 310 HLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVI 369 +LM + + T SVQW ER+LDDSA RRI L EAFL AD L LQNI+EGL+VYP V+ Sbjct: 322 YLMHISTSMVSTVSVQWLERSLDDSAIRRIVLPEAFLAADACLTLLQNIAEGLIVYPMVM 381 Query: 370 ERRIRQELPFMATENIIMAMVKAG-GSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQ 428 E + ELPF+ E I++ MV G +RQ+CHE++R S +AA+ +K +G N L++++ Sbjct: 382 EANLNSELPFLVVERILVKMVSEGAANRQECHERLRKHSHEAAAEIKLKGLKNSLMDKLL 441 Query: 429 VDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKAELCL 484 D YF+PIHS L +LDPS GRA +QV+ FL EV P + Y+ + + + + + Sbjct: 442 NDYYFAPIHSLLPTVLDPSYMIGRAVEQVEVFLNTEVDPAIHSYKDCLALNSNITI 497 >1YIS-A nrPDB Length = 478 Score = 482 bits (1241), Expect = e-136, Method: Composition-based stats. Identities = 219/478 (45%), Positives = 303/478 (63%), Gaps = 6/478 (1%) Query: 8 GSPDSYRSPLASRYAS-PEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLP-ITDEQIQEM 65 S D + S L++RY + + S+ K WRQLW+WLAEAE+ LGL +T + I EM Sbjct: 2 ASEDKFESVLSTRYCKNSPLVSILSETNKATLWRQLWIWLAEAEKELGLKQVTQDAIDEM 61 Query: 66 KSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILR 125 KSN + D+ EE++L+HDVMAH H FG CP AAGIIHLGATSC+V DN DLI R Sbjct: 62 KSNRDVFDWPFIRSEERKLKHDVMAHNHAFGKLCPTAAGIIHLGATSCFVQDNADLIAYR 121 Query: 126 NALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQN 185 +++D +L + A VI RLA F+ + + T+G TH+Q A L TVGKR LW Q+L M Q+ Sbjct: 122 DSIDHILKRFATVIDRLAAFSLKNKEVVTVGRTHYQTASLVTVGKRGVLWAQELLMAFQS 181 Query: 186 LKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTR 245 L RD +RFRG+KG TGTQ SFL LF GD+ KVE LD++VT+KA F F+ITGQTY+R Sbjct: 182 LSEFRDKMRFRGIKGATGTQDSFLTLFAGDESKVEALDELVTKKANFSNRFLITGQTYSR 241 Query: 246 KVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCC 305 + D +++ L+ LGA+ K+CTDIR+L E+ EPFEK QIGSSAMPYK+NPM+SERCC Sbjct: 242 QQDSQLVFSLSLLGAAAKKVCTDIRVLQAFGELLEPFEKDQIGSSAMPYKKNPMKSERCC 301 Query: 306 SLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVY 365 +L+R L+ + L + Q ERTLDDSA RR+ + + LTA+ +L TLQNI EGL V Sbjct: 302 ALSRKLINAPQEALTILADQGLERTLDDSAGRRMLIPDVLLTAEALLTTLQNIFEGLSVQ 361 Query: 366 PKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIE 425 +++ + E+ F+ E +M + + G RQ H IR + +A + + D I Sbjct: 362 TDNVKKIVEDEIAFLGLEKAMMMLTEEGVDRQQAHAVIRKTALEAKQLQATQKVD---IR 418 Query: 426 RIQVDAYFSPIHSQLDHLL-DPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKAEL 482 + D +F + ++ L+ +P +FTGR Q + F+ +E+ P + Y +L Sbjct: 419 QTMADPFFDSVRDRVVGLVNNPINFTGRCVSQTESFIAKELKPTIDKYLDKSAGNVQL 476 >1F1O-A nrPDB Length = 431 Score = 446 bits (1147), Expect = e-125, Method: Composition-based stats. Identities = 122/447 (27%), Positives = 220/447 (49%), Gaps = 22/447 (4%) Query: 17 LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKM 76 + RY+ PEM +++D +F+ W ++ + EA LG+ I E ++ M+ N + D Sbjct: 1 MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGV-IPKEDVKVMRENA-SFDINR 58 Query: 77 AAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLA 136 E EK RHDV+A + +H G TS V D +L+ A D+LL L Sbjct: 59 ILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTALSYLLKQANDILLKDLE 118 Query: 137 RVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFR 196 R + + + AKE +G TH A+ TT G + LW +++ +L+ K+ + + Sbjct: 119 RFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEEMKRNLERFKQAKAGIEVG 178 Query: 197 GVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLA 256 + G GT A+ +++ V EK G K A I T QT R + ++ LA Sbjct: 179 KISGAVGTYANIDPF----------VEQYVCEKLGLKAAPIST-QTLQRDRHADYMATLA 227 Query: 257 SLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTL 314 + S+ K +IR L + +E+EE F K Q GSSAMP+KRNP+ SE +AR + Sbjct: 228 LIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSENMTGMARVIRGY 287 Query: 315 VMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIR 374 +M + + W ER + S+ RI L +A + + +LN NI + L V+P+ ++R + Sbjct: 288 MMTAYENVPL-WHERDISHSSAERIILPDATIALNYMLNRFSNIVKNLTVFPENMKRNMD 346 Query: 375 QELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIE-RIQVDAYF 433 + L + ++ +++A++ G +R++ ++ ++ + +A +++ +L+E ++ + Sbjct: 347 RTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAW---EKQVPFRELVEAEEKITSRL 403 Query: 434 SPIHSQLDHLLDPSSFTGRASQQVQRF 460 SP ++ D + +R Sbjct: 404 SP--EKIADCFDYNYHLKNVDLIFERL 428 >2PFM-A nrPDB Length = 444 Score = 446 bits (1146), Expect = e-125, Method: Composition-based stats. Identities = 120/459 (26%), Positives = 213/459 (46%), Gaps = 26/459 (5%) Query: 8 GSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKS 67 GS + + SRY PEM ++++ KF+ W ++ + EA LG I E +++++ Sbjct: 1 GSSHHHHHHMISRYTRPEMGAIWTEENKFKAWLEVEILACEAWAELG-DIPKEDVKKIRE 59 Query: 68 NLENIDFKMAAEEEKRLRHDVMAHVHTFGHC--CPKAAGIIHLGATSCYVGDNTDLIILR 125 + + D E EK RHDV+A + +H G TS V D IL+ Sbjct: 60 HA-SFDIDRIYEIEKETRHDVVAFTRAVSETPALGEERKWVHYGLTSTDVVDTALSYILK 118 Query: 126 NALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQN 185 A +++L L +S LA+ AKE +G TH A+ TT G + LW +++ +++ Sbjct: 119 QANEIILKDLENFVSILANKAKEHKYTIMMGRTHGVHAEPTTFGLKLGLWYEEMKRNVER 178 Query: 186 LKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTR 245 K+ + +R + G GT A+ ++K V E G + A I T QT R Sbjct: 179 FKQAANTVRVGKLSGAVGTYANIDPF----------VEKYVCENLGLEAAPIST-QTLQR 227 Query: 246 KVDIEVLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSER 303 +S LA + S+ K+ +IR L + +E+EE F K Q GSSAMP+KRNP+ SE Sbjct: 228 DRHAHYMSTLALIATSIEKMAVEIRGLQKSETREVEEAFAKGQKGSSAMPHKRNPIGSEN 287 Query: 304 CCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLV 363 LAR + +M + + W ER + S+ R+ L +A + + +LN NI + L Sbjct: 288 MTGLARVIRGYMMTAYENVPL-WHERDISHSSAERVILPDATIALNYMLNRFGNIVKNLT 346 Query: 364 VYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDL 423 VYP+ ++R + + + ++ +++ ++ G R++ ++ ++ + +A Sbjct: 347 VYPENMKRNMTRTYGLIYSQRVMLTLIDKGMVREEAYDIVQPKAMEA------WETQVQF 400 Query: 424 IERIQVDAYF--SPIHSQLDHLLDPSSFTGRASQQVQRF 460 E ++ D +++ + +R Sbjct: 401 KELVEADERITSKLTQEEINECFNYEHHMQHVDTIFERL 439 >2X75-A nrPDB Length = 431 Score = 444 bits (1143), Expect = e-125, Method: Composition-based stats. Identities = 113/440 (25%), Positives = 210/440 (47%), Gaps = 25/440 (5%) Query: 17 LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKM 76 + RY+ EM +++D+ ++ W ++ + EA LG I +Q+++ N ++ + Sbjct: 1 MIERYSREEMSNIWTDQNRYEAWLEVEILACEAWSELG-HIPKADVQKIRQNA-KVNVER 58 Query: 77 AAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLA 136 A E E+ RHDV+A + +H G TS V D +++ A D++ L Sbjct: 59 AQEIEQETRHDVVAFTRQVSETLGEERKWVHYGLTSTDVVDTALSFVIKQANDIIEKDLE 118 Query: 137 RVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFR 196 R I LA+ AK +G TH A+ TT G + LW ++ +LQ K+VR+++ Sbjct: 119 RFIDVLAEKAKNYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMQRNLQRFKQVREEIEVG 178 Query: 197 GVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLA 256 + G GT A+ +++ V + G A + T QT R ++ LA Sbjct: 179 KMSGAVGTFANIPP----------EIESYVCKHLGIGTAPVST-QTLQRDRHAYYIATLA 227 Query: 257 SLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTL 314 + S+ K +IR L +E+EE F K Q GSSAMP+KRNP+ SE ++R + Sbjct: 228 LIATSLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNPIGSENITGISRVIRGY 287 Query: 315 VMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIR 374 + + + W ER + S+ RI L + + D LN NI + L V+ + I Sbjct: 288 ITTAYENVPL-WHERDISHSSAERIMLPDVTIALDYALNRFTNIVDRLTVFEDNMRNNID 346 Query: 375 QELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQA-------ASVVKQEGGDNDLIERI 427 + + ++ +++A++ G R++ ++K++ + + +++Q+ ++ + Sbjct: 347 KTFGLIFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRELIEQDESITSVLTKE 406 Query: 428 QVDAYFSPIH--SQLDHLLD 445 ++D F P H +Q+D + + Sbjct: 407 ELDECFDPKHHLNQVDTIFE 426 >4NLE-A nrPDB Length = 488 Score = 429 bits (1103), Expect = e-120, Method: Composition-based stats. Identities = 157/467 (33%), Positives = 231/467 (49%), Gaps = 4/467 (0%) Query: 15 SPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDF 74 + LA+RYAS EM ++S K R+LWL + A+ LG+ + D +++ + LEN+D Sbjct: 21 NVLANRYASDEMVAIWSPEAKIIAERRLWLAVLRAQAELGVAVPDGVVEDYERVLENVDL 80 Query: 75 KMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPK 134 + A E+ RHDV A + F +H G TS + +N + + +R +L+L+ Sbjct: 81 ESIAARERVTRHDVKARIEEFNALAGHEH--VHKGMTSRDLTENVEQLQIRQSLELVFSH 138 Query: 135 LARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLR 194 V++RLA+ A L G +H AQ TT+GKR ++ + L L+ + D Sbjct: 139 GVAVVARLAERAVVYRDLVMAGRSHNVAAQATTLGKRFASAAEETLVALTRLRELIDRYP 198 Query: 195 FRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSV 254 RGVKG GT L LF GD K+ L++ V E GF F GQ Y R +D +VLS Sbjct: 199 LRGVKGPMGTAQDMLDLFGGDVGKLADLERRVAEFLGFTEVFTSVGQVYPRSLDHDVLSA 258 Query: 255 LASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTL 314 L GA + IRL+A + + E F Q+GSSAMP+K N ER L L Sbjct: 259 LVQFGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGY 318 Query: 315 VMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIR 374 + A QW E + S RR+ L +AF D T + + YP VI+R + Sbjct: 319 ASMAAELAGAQWNEGDVFCSVVRRVALPDAFFAIDGQTETFLTVLDEFGAYPAVIQRELD 378 Query: 375 QELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFS 434 + LPF+AT I+MA V+AG R+ HE I+ + A ++++G + DLI+R+ D Sbjct: 379 RYLPFLATTRILMAAVRAGVGREAAHEVIKEHAVAVALAMREQGREPDLIDRLAGDPRLP 438 Query: 435 PIHSQLDHLL-DPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA 480 L+ L D +FTG A QV + V L+ Y K + Sbjct: 439 LDKVALEAALEDKQAFTGAAGDQVDGVVAA-VGELVSRYPEAAKYTS 484 >1C3C-A nrPDB Length = 429 Score = 428 bits (1100), Expect = e-120, Method: Composition-based stats. Identities = 107/446 (23%), Positives = 203/446 (45%), Gaps = 24/446 (5%) Query: 19 SRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAA 78 RY+ M ++++ K+R W ++ L + A + LG+ + + E N ID ++ Sbjct: 2 ERYSLSPMKDLWTEEAKYRRWLEVELAVTRAYEELGM--IPKGVTERIRNNAKIDVELFK 59 Query: 79 EEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARV 138 + E++ HDV+A V G + + H G TS V D + + L A +LL L Sbjct: 60 KIEEKTNHDVVAFVEGIGSMIGEDSRFFHYGLTSSDVLDTANSLALVEAGKILLESLKEF 119 Query: 139 ISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGV 198 L + A PT+G TH A+ T+ G + W ++ ++Q L+R +++ + + Sbjct: 120 CDVLWEVANRYKHTPTIGRTHGVHAEPTSFGLKVLGWYSEMKRNVQRLERAIEEVSYGKI 179 Query: 199 KGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASL 258 G G A+ ++++ G K + T Q R LS LA + Sbjct: 180 SGAVGNYANVPP----------EVEEKALSYLGLKPEPVST-QVVPRDRHAFYLSTLAIV 228 Query: 259 GASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVM 316 A + +I +IR L + E+EEPF K Q GSSAMP+K+NP+ ER L+R + V Sbjct: 229 AAGIERIAVEIRHLQRTEVLEVEEPFRKGQRGSSAMPHKKNPITCERLTGLSRMMRAYVD 288 Query: 317 DPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQE 376 L+ ++ W ER + S+ R +A T ++ T N+ + V + +++ I Sbjct: 289 PSLENIAL-WHERDISHSSVERYVFPDATQTLYYMIVTATNVVRNMKVNEERMKKNIDLT 347 Query: 377 LPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPI 436 + ++ +++ +++ G +R++ ++ ++ + +K + +E + D + Sbjct: 348 KGLVFSQRVLLKLIEKGLTRKEAYDIVQ------RNALKTWNSEKHFLEYLLEDEEVKKL 401 Query: 437 --HSQLDHLLDPSSFTGRASQQVQRF 460 +L+ L D S + +RF Sbjct: 402 VTKEELEELFDISYYLKHVDHIFERF 427 >1RE5-A nrPDB Length = 450 Score = 380 bits (975), Expect = e-106, Method: Composition-based stats. Identities = 119/455 (26%), Positives = 183/455 (40%), Gaps = 24/455 (5%) Query: 17 LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLG-LPITDEQIQEMKSNLENIDFK 75 + + +P M +FSDR + + LA AE + G +P + E E D Sbjct: 6 FDAYFTAPAMREIFSDRGRLQGMLDFEAALARAEASAGLVPHSAVAAIEAACQAERYDTG 65 Query: 76 MAAEEEKRLRHDVMAHVHTFGHC----CPKAAGIIHLGATSCYVGDNTDLIILRNALDLL 131 A + + V G P+A +HLGATS D ++ LR+ALDL+ Sbjct: 66 ALANAIATAGNSAIPLVKALGKVIATGVPEAERYVHLGATSQDAMDTGLVLQLRDALDLI 125 Query: 132 LPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRD 191 L ++ L+ A + A P +G T Q A T+G + + L Q L+ +R Sbjct: 126 EADLGKLADTLSQQALKHADTPLVGRTWLQHATPVTLGMKLAGVLGALTRHRQRLQELRP 185 Query: 192 DLRFRGVKGTTGTQAS-FLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIE 250 L G +G+ A+ + + EQL + E+ R +E Sbjct: 186 RLLVLQFGGASGSLAALGSKAMPVAEALAEQLKLTLPEQPWHT----------QRDRLVE 235 Query: 251 VLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLA 308 SVL + S+ K DI LL E+ EP + GSS MP+KRNP+ + A Sbjct: 236 FASVLGLVAGSLGKFGRDISLLMQTEAGEVFEPSAPGKGGSSTMPHKRNPVGAAVLIGAA 295 Query: 309 RHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKV 368 + L+ L A Q ER+L L + L Q I+EG+ V Sbjct: 296 TRVPGLL-STLFAAMPQEHERSLGLWHAEWETLPDICCLVSGALRQAQVIAEGMEVDAAR 354 Query: 369 IERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQ 428 + R + + E + + + + G R H + Q+A V +Q L + Q Sbjct: 355 MRRNLDLTQGLVLAEAVSIVLAQRLG-RDRAHHLLEQCCQRA--VAEQRHLRAVLGDEPQ 411 Query: 429 VDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEE 463 V A S +LD LLDP+ + G+A V R + E Sbjct: 412 VSAELS--GEELDRLLDPAHYLGQARVWVARAVSE 444 >3C8T-A nrPDB Length = 451 Score = 379 bits (974), Expect = e-105, Method: Composition-based stats. Identities = 108/461 (23%), Positives = 186/461 (40%), Gaps = 33/461 (7%) Query: 12 SYRSPLASR-YASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLE 70 S SPL R +A +M +FS + + + LA A+ LG+ I E + Sbjct: 2 SLDSPLYGRSFADDKMRELFSAQSFISRCVETEVALARAQARLGI------IPEDAAAGI 55 Query: 71 NIDFKMAAEEEKRLRHD-------VMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLII 123 + A E +RLR D ++ V +A +H GAT+ + D ++ Sbjct: 56 TAAARTFAPEMERLRDDTEIVGYPILPLVEQLSAHAGEAGKYLHWGATTQDIMDTATVLQ 115 Query: 124 LRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDL 183 +R+ L L+ ++ V LA A+ P G TH Q A T G + +W+ Sbjct: 116 IRDGLALISRRIESVRKALAALARNHRDTPMAGRTHLQHALPVTFGYKAAVWLSAFDRHA 175 Query: 184 QNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTY 243 L+ + + G +GT AS + + + + + I Sbjct: 176 ARLEEISPRVLVVEFSGASGTLASL-------GTRGLDVQRELARELNLGVPSITWHS-- 226 Query: 244 TRKVDIEVLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRS 301 R E + LA + S+ K+ DI ++ L E+ EPF + + SS MP K+NP+ Sbjct: 227 ARDAVAETVQFLALVSGSLGKLAMDISIMMTTELGEVAEPFVRHRGASSTMPQKQNPVSC 286 Query: 302 ERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEG 361 E + AR + L A + FER + E F A IL + + G Sbjct: 287 ELILAGARIVRNHATSMLD-AMIHDFERATGPWHLEWSAVPEGFAVASGILYQAEFMLGG 345 Query: 362 LVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDN 421 L V+P + + + E ++MA+ G R++ H+ + + ++A V+ + G Sbjct: 346 LQVFPDRMRENLDHSRGLIVAEAVMMALAPHTG-RKEAHDIVYLGCRRA---VEDKTGLF 401 Query: 422 DLIERIQVDAYFSPIHSQ-LDHLLDPSSFTGRASQQVQRFL 461 +++ + A P+ + L L DP ++ G A V L Sbjct: 402 EVLRTMPEVA--KPLGEEALRDLTDPRNYLGSAGAMVDNVL 440 >1Q5N-A nrPDB Length = 454 Score = 377 bits (967), Expect = e-105, Method: Composition-based stats. Identities = 110/471 (23%), Positives = 196/471 (41%), Gaps = 35/471 (7%) Query: 5 GDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLG-LPITDEQIQ 63 G H S AS + ++ +FSDR + + LA+A+ +G +P + + Sbjct: 1 GSHMSQLY-----ASLFYQRDVTEIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVI 55 Query: 64 E--MKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKA----AGIIHLGATSCYVGD 117 + K+ ++ IDF A + + V A A +H GATS + D Sbjct: 56 QRAAKTAIDKIDFDALATATGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILD 115 Query: 118 NTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQ 177 ++ R+AL ++ ++ + A+ +G T Q A T+G + W Sbjct: 116 TACILQCRDALAIVQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWAS 175 Query: 178 DLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFI 237 DL + ++ + + G G+ AS ++ +V E + Sbjct: 176 AFKRDLDRINAIKARVLVAQLGGAVGSLAS-----------LQDQGSIVVEAYAKQLKLG 224 Query: 238 ITGQTYT--RKVDIEVLSVLASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMP 293 T T+ R +E+ SVL + +V K+ D L+ + E+ EP K + GSS MP Sbjct: 225 QTACTWHGERDRIVEIASVLGIITGNVGKMARDWSLMMQTEIAEVFEPTAKGRGGSSTMP 284 Query: 294 YKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILN 353 +KRNP+ + + A + L M + + VQ ER+L + L E F L Sbjct: 285 HKRNPVAAASVLAAANRVPAL-MSSIYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALE 343 Query: 354 TLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASV 413 ++ +G+ V + + + I + E ++MA+ G R + H + + A Sbjct: 344 RTLDVLKGMEVNAENMHQNIECTHGLIMAEAVMMALAPHMG-RLNAHHVVEAACKTA--- 399 Query: 414 VKQEGGDNDLIERI-QVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEE 463 V ++ D+I ++ +V YF+P SQLD + P S+ G Q+ L+E Sbjct: 400 VAEQKHLKDIISQVDEVKQYFNP--SQLDEIFKPESYLGNIQDQIDAVLQE 448 >4EEI-A nrPDB Length = 438 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 94/450 (20%), Positives = 195/450 (43%), Gaps = 23/450 (5%) Query: 17 LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKM 76 + RY E+ +++D K+ ++ L + EA + +P ++ + + Sbjct: 1 MIKRYDVAEISKIWADENKYAKMLEVELAILEALEDRMVPKGTAAEIRARAQIRP---ER 57 Query: 77 AAEEEKRLRHDVMAHVHTFGHCCPKAAG-IIHLGATSCYVGDNTDLIILRNALDLLLPKL 135 E EK +HD++A + G H G TS + D+ + +R+++ ++ L Sbjct: 58 VDEIEKVTKHDIIAFCTSIAEQFTAETGKFFHFGVTSSDIIDSALSLQIRDSMSYVIKDL 117 Query: 136 ARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRF 195 + L A+E + T+G +H A+ + G++ + L++LK + D Sbjct: 118 EALCDSLLTKAEETKEIITMGRSHGMFAEPMSFGQKFLGAYVEFKRRLKDLKDFQKDGLT 177 Query: 196 RGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVL 255 G G + L D+ K + + E+ ++ Q R +++S+ Sbjct: 178 VQFSGAVGN---YCILTTEDEKKAADILGLPVEE--------VSTQVIPRDRIAKLISIH 226 Query: 256 ASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMT 313 + +++ ++ +IR L +++ E+ E F K Q GSS MP+K+NP+ +E +AR L + Sbjct: 227 GLIASAIERLAVEIRHLHRSDVFEVYEGFSKGQKGSSTMPHKKNPISTENLTGMARMLRS 286 Query: 314 LVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRI 373 V L+ V W ER + S+ R L + F L ++N + LVV +IE R+ Sbjct: 287 HVSIALENC-VLWHERDISHSSAERFYLPDNFGIMVYALRRMKNTIDNLVVQRDIIEDRV 345 Query: 374 RQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAY- 432 R ++++ + + R+DC++ + QQ A +KQ + ++++ D + Sbjct: 346 RSTSAYLSSFYLHFLVANTPFMREDCYKIV----QQVAFDLKQGESFSKKLQKVMHDEHN 401 Query: 433 FSPIHSQLDHLLDPSSFTGRASQQVQRFLE 462 ++D ++ R ++ Sbjct: 402 IILDIPEMDFEGIKKTYLKEIDHVFDRSVK 431 >2QGA-B nrPDB Length = 465 Score = 348 bits (892), Expect = 4e-96, Method: Composition-based stats. Identities = 115/492 (23%), Positives = 201/492 (40%), Gaps = 65/492 (13%) Query: 8 GSPD-SYRSPLASRY--ASPEMCFVFSDRY--KFRTWRQL-WLWLAEAEQTLGLPITD-- 59 GS SP+ RY A E+ FS+ K R ++ WL E+ +TD Sbjct: 1 GSEHLKNISPIDGRYKKACGELSAFFSEHALIKHRIIVEVRWLLFLNEEELFFEKVTDHS 60 Query: 60 -EQIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCP--------KAAGIIHLGA 110 E + ++ +N+ + D E+ HDV A + K +H Sbjct: 61 VEVLNQIATNITDSDIARVKAIEEETNHDVKAVEYFVKEKLKNSKREDLLKIKEYVHYLC 120 Query: 111 TSCYVGDNTDLIILRNAL-DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVG 169 TS + + L+ L D+++P L +++ +L D A E + +P L TH QPA TT G Sbjct: 121 TSEDINNVAYATCLKACLNDVVIPCLEKIMLKLKDLAVEYSHVPLLSRTHGQPASSTTFG 180 Query: 170 KRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEK 229 K + + + ++RV+ +F G G + KV D Sbjct: 181 KEMANFYARIHHHVGVIRRVKVCAKFN---GAVGNFNAH---------KVASKDTDWVNT 228 Query: 230 AGF--KRAFIITGQTYTRKVD-----IEVLSVLASLGASVHKICTDIRLLANLKEMEEPF 282 G K+ F +T Y ++ E+ LA ++ +C DI L + ++ Sbjct: 229 IGLFLKKHFNLTYSIYCTQIQDHDYICELCDGLARANGTLIDLCVDIWLYISNNLLKLKV 288 Query: 283 EKQQIGSSAMPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSA---N 336 +++++GSS MP+K NP+ +E +A L L T+ +Q R L DS N Sbjct: 289 KEKEVGSSTMPHKVNPIDFENAEGNLHIANAFFKLFSSKLPTSRLQ---RDLSDSTVLRN 345 Query: 337 RRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSR 396 LA + ++L L I + + +E + Q +A + +V + Sbjct: 346 IGSSLAYCLIAYKSVLKGLNKID----IDRRNLEEELNQNWSTLAEP---IQIVMKRHNY 398 Query: 397 QDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLD--PSSFTGRAS 454 D +E+++ ++ V+ Q+ + E I+ F P +D LL+ P+++TG A Sbjct: 399 VDAYEELKQFTR--GKVIDQKI----MQEFIKTKCAFLP-QDVVDQLLELTPATYTGYAD 451 Query: 455 ---QQVQRFLEE 463 + V+R E Sbjct: 452 YLAKNVERLSGE 463 >4EFC-A nrPDB Length = 472 Score = 326 bits (836), Expect = 1e-89, Method: Composition-based stats. Identities = 103/479 (21%), Positives = 194/479 (40%), Gaps = 63/479 (13%) Query: 9 SPDSYRSPLASRYASPE--MCFVFSDR--YKFRTWRQLWLWLAEAEQTLGL----PITDE 60 +P SPL RY + FS+ +++R ++ + A + + +TDE Sbjct: 19 NPLFALSPLDGRYKRQTKALRAFFSEYGFFRYRVLVEVEYFTALCKDVPTIVPLRSVTDE 78 Query: 61 QIQEMKSNLENI----DFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAG------IIHLGA 110 Q+Q+++ + + E+ HD+ A V F G +H G Sbjct: 79 QLQKLRKITLDCFSVSSAEEIKRLERVTNHDIKA-VEYFIKERMDTCGLSHVTEFVHFGL 137 Query: 111 TSCYVGDNTDLIILRNAL-DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVG 169 TS + + +++R+A+ L LP L +I L + +P L TH QPA T + Sbjct: 138 TSQDINNTAIPMMIRDAIVTLYLPALDGIIGSLTSKLVDW-DVPMLARTHGQPASPTNLA 196 Query: 170 KRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEK 229 K +WI+ L + L V +F G TG + L + + + D + + Sbjct: 197 KEFVVWIERLREQRRQLCEVPTTGKF---GGATGNFNAHLVAYPSVNWRAFA-DMFLAKY 252 Query: 230 AGFKRAFIITGQTYTRKVDIEVLSVLASLGASVH----KICTDIRLLANLKEMEEPFEKQ 285 G KR Q T+ + + L+ L A +H +C D+ ++ ++ ++ Sbjct: 253 LGLKRQ-----QATTQIENYDHLAALCDACARLHVILIDMCRDVWQYISMGFFKQKVKEG 307 Query: 286 QIGSSAMPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRR---I 339 ++GSS MP+K NP+ +E +L+ L+ L + +Q R L DS R + Sbjct: 308 EVGSSTMPHKVNPIDFENAEGNLALSNALLNFFASKLPISRLQ---RDLTDSTVLRNLGV 364 Query: 340 CLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDC 399 + A + +I L E L++ + I R + +A E I + R++C Sbjct: 365 PIGHACVAFASISQGL----EKLMISRETISRELSSNWAVVA-EGIQTVL------RREC 413 Query: 400 ----HEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRAS 454 +E ++ L+Q V +++ + D + ++L + P ++ G Sbjct: 414 YPKPYETLKKLTQGNTDVTEEQVRNFINGLTDISDD----VRAELLAIT-PFTYVGYVP 467 >1DOF-A nrPDB Length = 403 Score = 323 bits (827), Expect = 1e-88, Method: Composition-based stats. Identities = 107/395 (27%), Positives = 187/395 (47%), Gaps = 17/395 (4%) Query: 13 YRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENI 72 + SP RY S E+ +F++ + ++ L A + LG+ E+ K N ++ Sbjct: 2 HVSPFDWRYGSEEIRRLFTNEAIINAYLEVERALVCALEELGVA---ERGCCEKVNKASV 58 Query: 73 DFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLL 132 E+ HD+++ V +H GATS + D +++R AL + Sbjct: 59 SADEVYRLERETGHDILSLVLLLEQ--KSGCRYVHYGATSNDIIDTAWALLIRRALAAVK 116 Query: 133 PKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDD 192 K V +LA A++ +L +G TH Q A+ T+G + + +L + + L + Sbjct: 117 EKARAVGDQLASMARKYKTLEMVGRTHGQWAEPITLGFKFANYYYELYIACRQLALAEEF 176 Query: 193 LRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVL 252 +R + G GT AS+ +L ++ + V E+ G +IT Q R+ + Sbjct: 177 IR-AKIGGAVGTMASWGELGL-------EVRRRVAERLGLPHH-VITTQVAPRESFAVLA 227 Query: 253 SVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLM 312 S LA + A ++ +IR L + E+ E E SSAMP+K NP SER SLAR++ Sbjct: 228 SALALMAAVFERLAVEIREL-SRPEIGEVVEGGGG-SSAMPHKANPTASERIVSLARYVR 285 Query: 313 TLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERR 372 L + ++ W ER L +SAN R+ + EA L D IL + + + + + + I Sbjct: 286 ALTHVAFENVAL-WHERDLTNSANERVWIPEALLALDEILTSALRVLKNVYIDEERITEN 344 Query: 373 IRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLS 407 +++ LP++ TE + M+K G SR + ++K + + Sbjct: 345 LQKALPYILTEFHMNRMIKEGASRAEAYKKAKEVK 379 >4MX2-A nrPDB Length = 480 Score = 310 bits (795), Expect = 7e-85, Method: Composition-based stats. Identities = 97/471 (20%), Positives = 188/471 (39%), Gaps = 45/471 (9%) Query: 9 SPDSYRSPLASRYASP--EMCFVFSDRY--KFRTWRQLWLWLAEAEQTLGLP----ITDE 60 SP SPL RY + FS+ K+R ++ + A ++ + +TD Sbjct: 30 SPLYSLSPLDGRYKRDTTPLRAYFSEYALFKYRVQVEVLYFEALCKEVPAITQLRGVTDA 89 Query: 61 QIQEMKS----NLENIDFKMAAEEEKRLRHDVMAHVHTFGHC-----CPKAAGIIHLGAT 111 Q+ E+++ N D K+ E HD+ A + IH G T Sbjct: 90 QLGELRATTFENFAVDDAKIIKGIEAVTNHDIKAVEYYLKDKMSACGLEAEKEFIHFGLT 149 Query: 112 SCYVGDNTDLIILRNALDL-LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGK 170 S + + + ++LR+AL +P L ++I+ L E +P L TH QPA T + K Sbjct: 150 SQDINNTSIPMLLRDALHHHYIPTLDQLIALLKSKLPEW-DVPMLARTHGQPASPTNLAK 208 Query: 171 RCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKA 230 +WI+ L L + + +F G TG + L + G + + +++ Sbjct: 209 EFMVWIERLEEQRTMLLSIPNTGKF---GGATGNFNAHLCAYPGVNWLDFG-ELFLSKYL 264 Query: 231 GFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSS 290 G +R T Q + A L + + D+ +L ++ ++GSS Sbjct: 265 GLRRQRY-TTQIEHYDNLAAICDACARLHTILMDLAKDVWQYISLGYFDQKVRAGEVGSS 323 Query: 291 AMPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRR---ICLAEA 344 AMP+K NP+ +E ++ ++ + L + +Q R L DS R + L+ A Sbjct: 324 AMPHKVNPIDFENAEGNLGMSNAVLGFLSAKLPISRLQ---RDLTDSTVLRNLGVPLSHA 380 Query: 345 FLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIR 404 + ++ + L++ VI + +A E I + + G +E ++ Sbjct: 381 LIAFASLRRG----IDKLLLNKDVIASDLEGNWAVVA-EGIQTVLRREG--YPKPYEALK 433 Query: 405 VLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQ 455 L++ A V ++ +++++ + +L + P ++ G + Sbjct: 434 DLTRGNAHVTEETVHR--FVQQLEGITE--EVRQELLAIT-PFTYVGYTAH 479 >3BHG-A nrPDB Length = 459 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 90/474 (18%), Positives = 178/474 (37%), Gaps = 56/474 (11%) Query: 15 SPLASRYA------SPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQ----IQE 64 SP+ RY SP Y+ + + LA + +P D + + + Sbjct: 13 SPIDGRYVNKTRALSPYFSEFALTYYRLMVEIKWFESLAANDTIPEVPALDNKARKFLSD 72 Query: 65 MKSNLENIDFKMAAEEEKRLRHDVMAHVHTF------GHCCPKAAGIIHLGATSCYVGDN 118 + SN + + E EK+ HDV A + IH TS + + Sbjct: 73 LISNFNESEAEKIKEFEKQTNHDVKAVEYYLQDKFQENEQLKSCVAFIHFACTSEDINNL 132 Query: 119 TDLIILRNAL-DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQ 177 ++++ A+ ++ P +A ++ + K+ A + L TH QPA TT+GK ++ Sbjct: 133 AYALMIKQAIAQVIQPTIAEIMGSITLLGKQHADVAMLSRTHGQPATPTTMGKELVNFVA 192 Query: 178 DLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFI 237 L Q L V +F G G + + + D + A F + Sbjct: 193 RLKRPQQQLAEVLIPAKFN---GAVGNYNAHVAAYPEVDWR--------KHCANFVTSLG 241 Query: 238 ITGQTY-----TRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAM 292 ++ Y EV ++ + + DI +L ++ +++GSS M Sbjct: 242 LSFNAYTTQIEPHDGIAEVSQIMVRINNILLDYTQDIWSYISLGYFKQKTIAEEVGSSTM 301 Query: 293 PYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTAD 349 P+K NP+ +E L+ L + L + +Q R L DS R + Sbjct: 302 PHKVNPIDFENAEGNLGLSNALFIHFANKLTQSRMQ---RDLSDSTVLRNL----GVAFS 354 Query: 350 TILNTLQNISEG---LVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVL 406 L ++++G L + +++ + + +A + V + + +E+++ L Sbjct: 355 YSLIAYHSVAKGNDKLQINKSALQKDLSENWEVLAE---AIQTVMRRYNEPNAYEQLKEL 411 Query: 407 SQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRF 460 ++ + I+ + + ++L L P ++TG A+Q V+ F Sbjct: 412 TRGQMIDAEN---LKKFIKTLSIPEE---AKAELMKLT-PETYTGLATQLVKAF 458 >4NSL-A nrPDB Length = 470 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 89/475 (18%), Positives = 168/475 (35%), Gaps = 46/475 (9%) Query: 9 SPDSYRSPLASRYAS--PEMCFVFSDR----YKFRTWRQLWLWLAEAEQTLGLPITDEQ- 61 S + SP+ RY + +FS+ ++ + + LA +P Sbjct: 18 SSLTAVSPVDGRYGDKVSALRGIFSEYGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADA 77 Query: 62 ---IQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCP------KAAGIIHLGATS 112 + + +N D E+ HDV A + + IH TS Sbjct: 78 NGYLDTLVANFNEEDAARIKTIERTTNHDVKAVEYFLKEKVAAIPALHDVSEFIHFACTS 137 Query: 113 CYVGDNTDLIILRNALD-LLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKR 171 + + + ++L+ A D ++LP +VI+ + D A + +P L TH QPA +T+GK Sbjct: 138 EDINNLSHALMLKTARDEVILPYWRQVINAVKDLATQYRDIPLLSRTHGQPATPSTLGKE 197 Query: 172 CCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAG 231 + + L +V + G G + + + D Q + G Sbjct: 198 MANVAYRMERQFRQLNQVEI---LGKINGAVGNYNAHIAAYPEVDWH--QFSEEFVTSLG 252 Query: 232 FKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSA 291 + T Q E+ +A + D+ L ++ +IGSS Sbjct: 253 IQWNPY-TTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALNHFKQKTIAGEIGSST 311 Query: 292 MPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRIC---LAEAF 345 MP+K NP+ SE L+ ++ + + L V ++R L DS R + A Sbjct: 312 MPHKVNPIDFENSEGNLGLSNAVLHHLANKL---PVSRWQRDLTDSTVLRNLGVGIGYAL 368 Query: 346 LTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRV 405 + + L L V + + +A + V + +EK++ Sbjct: 369 IAYQSTLKG----VSKLEVNRDHLLDELDHNWEVLAEP---IQTVMRRYGIEKPYEKLKE 421 Query: 406 LSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRF 460 L++ + G I+ + + ++L + P+++ GRA V Sbjct: 422 LTRGKRVDAE---GMKQFIDSLALPEA---EKTRLKAMT-PANYIGRAVTLVDEL 469 >2PTS-A nrPDB Length = 462 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 88/475 (18%), Positives = 167/475 (35%), Gaps = 46/475 (9%) Query: 9 SPDSYRSPLASRYAS--PEMCFVFSDR----YKFRTWRQLWLWLAEAEQTLGLPITDEQ- 61 S + SP+ RY + +FS+ ++ + + LA +P Sbjct: 4 SSLTAVSPVDGRYGDKVSALRGIFSEYGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADA 63 Query: 62 ---IQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKA------AGIIHLGATS 112 + + ++ D E+ HDV A + + + IH TS Sbjct: 64 IGYLDAIVASFSEEDAARIKTIERTTNHDVKAVEYFLKEKVAEIPELHAVSEFIHFACTS 123 Query: 113 CYVGDNTDLIILRNALD-LLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKR 171 + + + ++L+ A D ++LP ++I L D A + +P L TH QPA +T+GK Sbjct: 124 EDINNLSHALMLKTARDEVILPYWRQLIDGLKDLAVQYRDIPLLSRTHGQPATPSTIGKE 183 Query: 172 CCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAG 231 + + L +V + G G + + + D Q + G Sbjct: 184 MANVAYRMERQYRQLNQVEI---LGKINGAVGNYNAHIAAYPEVDWH--QFSEEFVTSLG 238 Query: 232 FKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSA 291 + T Q E+ +A + D+ L ++ +IGSS Sbjct: 239 IQWNPY-TTQIEPHDYIAELFDCVARFNTILIDFDRDVWGYIALNHFKQKTIAGEIGSST 297 Query: 292 MPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRIC---LAEAF 345 MP+K NP+ SE L+ ++ + L V ++R L DS R + A Sbjct: 298 MPHKVNPIDFENSEGNLGLSNAVLQHLASKL---PVSRWQRDLTDSTVLRNLGVGIGYAL 354 Query: 346 LTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRV 405 + + L L V + + +A + V + +EK++ Sbjct: 355 IAYQSTLKG----VSKLEVNRDHLLDELDHNWEVLAEP---IQTVMRRYGIEKPYEKLKE 407 Query: 406 LSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRF 460 L++ + G I+ + + ++L + P+++ GRA V Sbjct: 408 LTRGKRVDAE---GMKQFIDGLALPEE---EKARLKAMT-PANYIGRAITMVDEL 455 >5E3V-A nrPDB Length = 380 Score = 274 bits (701), Expect = 5e-74, Method: Composition-based stats. Identities = 74/372 (19%), Positives = 134/372 (36%), Gaps = 32/372 (8%) Query: 9 SPDSYRSPLASRYAS--PEMCFVFSDR----YKFRTWRQLWLWLAEAEQTLGLPITDEQ- 61 S + SP+ RY + +FS+ ++ + + LA +P Sbjct: 18 SSLTAVSPVDGRYGDKVSALRGIFSEYGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADA 77 Query: 62 ---IQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCP------KAAGIIHLGATS 112 + + +N D E+ HDV A + + IH TS Sbjct: 78 NGYLDTLVANFNEEDAARIKTIERTTNHDVKAVEYFLKEKVAAIPALHDVSEFIHFACTS 137 Query: 113 CYVGDNTDLIILRNALD-LLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKR 171 + + + ++L+ A D ++LP +VI+ + D A + +P L TH QPA +T+GK Sbjct: 138 EDINNLSHALMLKTARDEVILPYWRQVINAVKDLATQYRDIPLLSRTHGQPATPSTLGKE 197 Query: 172 CCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAG 231 + + L +V + G G + + + D Q + G Sbjct: 198 MANVAYRMERQFRQLNQVEI---LGKINGAVGNYNAHIAAYPEVDWH--QFSEEFVTSLG 252 Query: 232 FKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSA 291 + T Q E+ +A + D+ L ++ +IGSS Sbjct: 253 IQWNPY-TTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALNHFKQKTIAGEIGSST 311 Query: 292 MPYKRNPM---RSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRIC---LAEAF 345 MP+K NP+ SE L+ ++ + + L V ++R L DS R + A Sbjct: 312 MPHKVNPIDFENSEGNLGLSNAVLHHLANKL---PVSRWQRDLTDSTVLRNLGVGIGYAL 368 Query: 346 LTADTILNTLQN 357 + + L + Sbjct: 369 IAYQSTLKGVSK 380 >5UPP-A nrPDB Length = 466 Score = 257 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 68/308 (22%), Positives = 116/308 (37%), Gaps = 14/308 (4%) Query: 112 SCYVGDN-TDLIILRNALDL---LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTT 167 S D + + A+++ LLP L ++ L +KE A + +G TH Q A T Sbjct: 140 SQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLT 199 Query: 168 VGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVT 227 +G+ ++Q + + +K + GT + L G KV +T Sbjct: 200 LGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGT--AVGTGLNTRIGFAEKVAAKVAALT 257 Query: 228 EKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPF 282 F A +E+ + + S+ KI DIR L + L E+ P Sbjct: 258 G-LPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILP- 315 Query: 283 EKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLA 342 + + GSS MP K NP + E +A +M + S FE + + L Sbjct: 316 -ENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLH 374 Query: 343 EAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEK 402 A L D ++ +N G+ + I + + + L + N + KA + H+ Sbjct: 375 SARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKN 434 Query: 403 IRVLSQQA 410 L + A Sbjct: 435 GSTLKETA 442 >5XNZ-A nrPDB Length = 489 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 106/447 (23%), Positives = 166/447 (37%), Gaps = 19/447 (4%) Query: 32 DRYKFRTWRQLWLWLAEAEQTLG-LPITDEQIQEMKSNLENIDFKMAAEEEKRLRHDVMA 90 D + L A+ G LP + + + ID A + + V+ Sbjct: 51 DSAWLQAMLDAEAALTRAQARTGFLPAAAAEAITAAARADRIDLLAVARGARETANPVVG 110 Query: 91 HVHTFGHCC----PKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFA 146 V P AA +H G+TS V D +++ R AL L+ L R LA A Sbjct: 111 LVAALTAAVRRDDPAAAEYVHRGSTSQDVLDTGAMLVARRALRLIGDDLDRAADALAALA 170 Query: 147 KERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQA 206 + P G T A TT G + W++ + + R+RD L F + G GT A Sbjct: 171 ADHRDTPMAGRTLALHAVPTTFGLKAAGWLELVSEAAGRVARLRDGLPF-SLGGAAGTLA 229 Query: 207 SFLQLFEGDDHKVEQLDKMVTEKA---GFKRAFIITGQTYTRKVDIEVLSVLASLGASVH 263 + LD+++ A G R + T ++ +VLA ++ Sbjct: 230 GYFGDRTDRGDPAVLLDRLLDAYAAETGLARPVLPWHVLRTP--VADLAAVLAFTAGALG 287 Query: 264 KICTDIRLLA--NLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQT 321 KI D++ LA + E+ EP + + SSAMP+KRNP+ S S A + L L Sbjct: 288 KIAVDVQSLARTEVAEVAEPAVEGRGASSAMPHKRNPVLSTLIRSAALQVPAL-ATGLTQ 346 Query: 322 ASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMA 381 V ER+ L E T ++ GL V + + + Sbjct: 347 CLVSEDERSAGAWHAEWQPLRECLRLTGGAARTAVELAAGLEVDAARMRANLDLTDGRIV 406 Query: 382 TENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLD 441 +E++ +A+ G RQ E + + A + L E ++D + + Sbjct: 407 SESVAVALTPLLG-RQAAKELLTRAAFTAGH--EGRTLGEVLGELPELDGVLP--KERWE 461 Query: 442 HLLDPSSFTGRASQQVQRFLEEEVYPL 468 LLDP+ TG A V L P Sbjct: 462 ALLDPARATGVAGALVDGALARRRPPA 488 >2FEL-A nrPDB Length = 359 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 80/351 (22%), Positives = 137/351 (39%), Gaps = 18/351 (5%) Query: 13 YRSP-LASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLEN 71 + P L+ + E+ +FS + + LA+AE + D++ + + S L Sbjct: 6 FEHPFLSGLFGDSEIIELFSAKADIDAMIRFETALAQAEAEASI-FADDEAEAIVSGLSE 64 Query: 72 IDFKMAAEEEKRLRHDVMA--HVHTF-GHCCPKAAGIIHLGATSCYVGDNTDLIILRNAL 128 M+A + V+ + +AA +H GATS V D + ++ L+ A Sbjct: 65 FAADMSALRHGVAKDGVVVPELIRQMRAAVAGQAADKVHFGATSQDVIDTSLMLRLKMAA 124 Query: 129 DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKR 188 +++ +L +I L D A P G+T Q A TV R WI L L L+ Sbjct: 125 EIIATRLGHLIDTLGDLASRDGHKPLTGYTRMQAAIGITVADRAAGWIAPLERHLLRLET 184 Query: 189 VRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVD 248 + G GT E + + ++ G Q R Sbjct: 185 FAQNGFALQFGGAAGTL-------EKLGDNAGAVRADLAKRLGLADRPQWHNQ---RDGI 234 Query: 249 IEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLA 308 E ++L+ + ++ K DI L+A + E GSSAMP+K+NP+ +E +LA Sbjct: 235 AEFANLLSLVTGTLGKFGQDIALMAEIG--SEIRLSGGGGSSAMPHKQNPVNAETLVTLA 292 Query: 309 RHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNIS 359 R + + L + VQ ER+ + L + T L + ++ Sbjct: 293 R-FNAVQISALHQSLVQEQERSGAGWMLEWLTLPQMVTATGTSLLVAERLA 342 >3GTD-A nrPDB Length = 482 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 65/314 (20%), Positives = 116/314 (36%), Gaps = 11/314 (3%) Query: 106 IHLGATSCYVGDNTDLIILRNAL-DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ 164 ++ G +S I A L+P L +++ L D +K+ + +G TH Q A Sbjct: 155 VNKGQSSNDSFPTAMHIATVLATKQQLIPALNNLLTYLQDKSKDWDKIIKIGRTHLQDAT 214 Query: 165 LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDK 224 T+ + +I + L+ ++ + GT + + G D K Q Sbjct: 215 PLTLKQEFSGYITQIEYALERIEDALKKVYLLAQGGT--AVGTGINSKIGFDIKFAQKVA 272 Query: 225 MVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEME 279 T++ FK A +E L ++ S+ KI DIRLL + L E+ Sbjct: 273 EFTQQP-FKTAPNKFESLAAHDALVEFSGTLNTIAVSLMKIANDIRLLGSGPRCGLGELH 331 Query: 280 EPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRI 339 P + + GSS MP K NP + E + +M + S E + Sbjct: 332 LP--ENEPGSSIMPGKVNPTQVEALTMVCTQVMGNHVTVTIAGSNGHLELNVFKPVIIYN 389 Query: 340 CLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDC 399 L L +D++ + + + +GL I + L + N + A ++ Sbjct: 390 ILQSIELLSDSVNSFVTHCVKGLEPNIARINTLRDKSLMLVTVLNPHIGYDNAAKIAKEA 449 Query: 400 HEKIRVLSQQAASV 413 H+ L + A + Sbjct: 450 HKYGITLKEAAKKL 463 >1YFM-A nrPDB Length = 488 Score = 233 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 69/335 (20%), Positives = 121/335 (36%), Gaps = 22/335 (6%) Query: 112 SCYVGDN-TDLIILRNALDL---LLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTT 167 S D ++ + +L + L+P+L + + L +KE + +G TH Q A T Sbjct: 162 SQSSNDTFPTVMHIAASLQIQNELIPELTNLKNALEAKSKEFDHIVKIGRTHLQDATPLT 221 Query: 168 VGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVT 227 +G+ ++Q + +Q + L F GT + L G D K+ + T Sbjct: 222 LGQEFSGYVQQVENGIQRVAHSLKTLSFLAQGGT--AVGTGLNTKPGFDVKIAEQISKET 279 Query: 228 EKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPF 282 F+ A +E L +L S+ KI DIR L + E+ P Sbjct: 280 G-LKFQTAPNRFEALAAHDAIVECSGALNTLACSLFKIAQDIRYLGSGPRCGYHELMLP- 337 Query: 283 EKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLA 342 + + GSS MP K NP ++E + +M S FE + L Sbjct: 338 -ENEPGSSIMPGKVNPTQNEALTQVCVQVMGNNAAITFAGSQGQFELNVFKPVMIANLLN 396 Query: 343 EAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEK 402 L D + + EG+ I + + L + N + A ++ H+K Sbjct: 397 SIRLITDAAYSFRVHCVEGIKANEPRIHELLTKSLMLVTALNPKIGYDAASKVAKNAHKK 456 Query: 403 IRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIH 437 +K+ + ++ + D + P H Sbjct: 457 --------GITLKESALELGVLTEKEFDEWVVPEH 483 >3TV2-A nrPDB Length = 459 Score = 225 bits (572), Expect = 5e-59, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 113/314 (35%), Gaps = 11/314 (3%) Query: 106 IHLGATSCYVGDNTDLIIL-RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ 164 ++ G +S V I R +D LLP L + + L A A + +G TH Q A Sbjct: 130 VNRGQSSNDVFPTAMHIAAARAIVDHLLPALRTLRATLDAKAAAFADIVKIGRTHLQDAT 189 Query: 165 LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDK 224 T+G+ ++ L +++++ L GT + L V Sbjct: 190 PLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGT--AVGTGLNAHPKFAAGVAAEIG 247 Query: 225 MVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEME 279 +T F A + L ++ AS+ KI DIR LA+ L E+ Sbjct: 248 RLTG-LPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELS 306 Query: 280 EPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRI 339 P + + GSS MP K NP +SE L + + + FE + Sbjct: 307 IP--ENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHN 364 Query: 340 CLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDC 399 L L AD + + G+ I+ + + L + N + KA + Sbjct: 365 VLQSVRLLADGAQGFNDHCAVGIEPNRARIDALLNESLMLVTALNPHIGYDKAAQIAKKA 424 Query: 400 HEKIRVLSQQAASV 413 H++ L A ++ Sbjct: 425 HKEGTTLKAAALAL 438 >1FUP-A nrPDB Length = 472 Score = 220 bits (561), Expect = 9e-58, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 115/298 (38%), Gaps = 11/298 (3%) Query: 112 SCYVGDNTDLIILRNALD-LLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGK 170 S V + AL L+P+L + L + ++ A + +G TH Q A T+G+ Sbjct: 140 SNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQ 199 Query: 171 RCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKA 230 W+ L +L++++ + + GT + L +V + V A Sbjct: 200 EISGWVAMLEHNLKHIEYSLPHVAELALGGT--AVGTGLNTHPEYARRVAD-ELAVITCA 256 Query: 231 GFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQ 285 F A T ++ L L AS+ KI D+R LA+ + E+ P + Sbjct: 257 PFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIP--EN 314 Query: 286 QIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAF 345 + GSS MP K NP + E L +M + + FE + L Sbjct: 315 EPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVR 374 Query: 346 LTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKI 403 L AD + + ++ + G+ + I + + + L + N + KA + H++ Sbjct: 375 LLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEG 432 >4HGV-A nrPDB Length = 495 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 60/305 (19%), Positives = 102/305 (33%), Gaps = 11/305 (3%) Query: 112 SCYVGDNTDLIIL-RNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGK 170 S I + LLP L + L + K + +G TH Q A T+G+ Sbjct: 172 SNDTYPTAMHIACAERVIHDLLPALKHLHKALEEKVKAFDHIIKIGRTHTQDATPLTLGQ 231 Query: 171 RCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKA 230 + + ++ ++ L GT + L G KV + +T Sbjct: 232 EFSGYAAQVASSIKRIEMTLPGLCELAQGGT--AVGTGLNAPVGFAEKVAEEIAAITG-I 288 Query: 231 GFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQ 285 GF A + + + A++ KI DIR L + L E+ P + Sbjct: 289 GFTSAPNKFEALAAHDSMVFSHGAINATAAALFKIANDIRFLGSGPRSGLGELSLP--EN 346 Query: 286 QIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAF 345 + GSS MP K NP + E + + S FE + + L Sbjct: 347 EPGSSIMPGKVNPTQCEALTQVCVQVFGNHAALTFAGSQGHFELNVYNPLMAYNFLQSVQ 406 Query: 346 LTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRV 405 L AD ++ N G+ I+ + + L + + A + H+ Sbjct: 407 LLADAAISFTDNCVVGIEAREDNIKAALDRSLMLVTALAPKIGYDNAAKIAKTAHKNGTT 466 Query: 406 LSQQA 410 L ++A Sbjct: 467 LREEA 471 >3RD8-A nrPDB Length = 489 Score = 215 bits (546), Expect = 5e-56, Method: Composition-based stats. Identities = 67/355 (18%), Positives = 125/355 (35%), Gaps = 14/355 (3%) Query: 86 HDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIIL-RNALDLLLPKLARVISRLAD 144 ++V+A + +++ +S I A+ L+P L + + LA Sbjct: 132 NEVIASIAAANGVTVHPNDHVNMSQSSNDTFPTATHIAATEAAVRHLIPALEVLHASLAA 191 Query: 145 FAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGT 204 AK+ ++ G TH A T+G+ + + + ++ +K L + GT Sbjct: 192 KAKQWRTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELAIGGT--A 249 Query: 205 QASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHK 264 + L EG KV ++ T A + A R +E L ++ S+ K Sbjct: 250 VGTGLNAPEGFGAKVVEVLVNETGLAELRTAVDSFEAQAARDGLVEASGALRTIAVSLTK 309 Query: 265 ICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPL 319 I DIR + + L E++ P Q GSS MP K NP+ E +A ++ Sbjct: 310 IANDIRWMGSGPLTGLAEIQLP--DLQPGSSIMPGKVNPVLPEAVTQVACQVVGNDAAIA 367 Query: 320 QTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPF 379 + FE + R L L ++ + +GLV + + Sbjct: 368 FGGASGAFELNVYIPMMARNLLESFTLLSNVSRLFAERCIDGLVANEERLRELAESSPSI 427 Query: 380 MATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFS 434 + N + +A + + + + Q G D + ++D Sbjct: 428 VTPLNSAIGYEEAAKVAKQALAEKKTIRQTVI----DRGLIGDKLSLEELDRRLD 478 >3RRP-A nrPDB Length = 471 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 117/333 (35%), Gaps = 26/333 (7%) Query: 107 HLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLT 166 HL AT V D L+P L + LA AK ++ G TH A Sbjct: 151 HLAATEAAVRD-------------LIPALEYLQQALATKAKAWKTVVKSGRTHLMDAVPV 197 Query: 167 TVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMV 226 T+G+ + + + ++ +K L + GT + L +G KV ++ K Sbjct: 198 TLGQEFGGYARQIEAGIERVKATLPRLGELPIGGT--AVGTGLNAPDGFGAKVVEVLKQS 255 Query: 227 TEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEP 281 T + K A R +E L ++ AS+ KI DIR + + L E++ P Sbjct: 256 TGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIANDIRWMGSGPLTGLGEIQLP 315 Query: 282 FEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICL 341 Q GSS MP K NP+ E +A ++ FE + R L Sbjct: 316 --DLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAITVGGLSGAFELNVYIPVMARNLL 373 Query: 342 AEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHE 401 L A+ + +GLV + + N + +A ++ + Sbjct: 374 ESFTLLANVSRLFVDKCVDGLVANEDHLRTLAESSPSIVTPLNSAIGYEEAAAVAKEALK 433 Query: 402 KIRVLSQQAASVVKQEGGDNDLIERIQVDAYFS 434 + + + Q G D + ++D Sbjct: 434 ERKTIRQTVI----DRGLIGDKLSIEELDKRLD 462 >3QBP-A nrPDB Length = 478 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 66/355 (18%), Positives = 119/355 (33%), Gaps = 14/355 (3%) Query: 86 HDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIIL-RNALDLLLPKLARVISRLAD 144 ++V+A + +++ +S I A+ L+P L + LA Sbjct: 122 NEVIASIAGANGVAVHPNDDVNMSQSSNDTFPTATHIAATEAAVSHLIPALEILQDALAT 181 Query: 145 FAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGT 204 A E S+ G TH A T+G+ + + + ++ ++ L + GT Sbjct: 182 KALEWQSVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGT--A 239 Query: 205 QASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHK 264 + L EG KV + T + A R +E L ++ S+ K Sbjct: 240 VGTGLNAPEGFGVKVVSVLVSQTGLPQLRTAANSFEAQAARDGLVEASGALRTIAVSLTK 299 Query: 265 ICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPL 319 I DIR + + L E++ P Q GSS MP K NP+ E +A ++ Sbjct: 300 IANDIRWMGSGPLTGLAEIQLP--DLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAVA 357 Query: 320 QTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPF 379 + FE + R L L + Q GL + + Sbjct: 358 WGGANGAFELNVYIPMMARNILESFTLLTNVSKLFAQRCIAGLTANAEHLRELAESSPSI 417 Query: 380 MATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFS 434 + N + +A + ++ + + Q G D + ++D Sbjct: 418 VTPLNSAIGYEEAAAVAKQALKERKTIRQTVI----DRGLIGDKLSLEELDRRLD 468 >4ADL-A nrPDB Length = 495 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 64/352 (18%), Positives = 123/352 (34%), Gaps = 12/352 (3%) Query: 86 HDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIIL-RNALDLLLPKLARVISRLAD 144 ++V+A + G +++ +S I A+ L+P L ++ LA Sbjct: 135 NEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAA 194 Query: 145 FAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGT 204 A + ++ G TH A T+G+ + + + ++ ++ L + GT Sbjct: 195 KALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGT--A 252 Query: 205 QASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHK 264 + L + +V + T + + A R +E L ++ S+ K Sbjct: 253 VGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTK 312 Query: 265 ICTDIRLLAN-----LKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPL 319 I DIR + + L E++ P Q GSS MP K NP+ E +A ++ Sbjct: 313 IANDIRWMGSGPLTGLAEIQLP--DLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIA 370 Query: 320 QTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPF 379 + FE + R L L + Q GL + + R Sbjct: 371 WGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSI 430 Query: 380 MATENIIMAMVKAGGSRQDCHEKIRVLSQQA--ASVVKQEGGDNDLIERIQV 429 + N + +A + ++ + + Q ++ DL R+ V Sbjct: 431 VTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDV 482 >6N1M-A nrPDB Length = 472 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 62/325 (19%), Positives = 116/325 (35%), Gaps = 14/325 (4%) Query: 112 SCYVGDNTDLIILRNA-LDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGK 170 S I A + LLP + + A ++ +G TH Q A T+G+ Sbjct: 148 SNDTFPTAMHIAAAIAFNEKLLPAVRNLRHVFAAKMDAFKNIIKIGRTHLQDAVPLTLGQ 207 Query: 171 RCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKA 230 ++ L + L+ V +L GT + L KV + +T+ Sbjct: 208 EFSGYVAQLDACVHRLEEVLPELYELAAGGT--AVGTGLNTHPQFAVKVAEHIAKITK-L 264 Query: 231 GFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQ 285 F A + + + + +L ++ KI DIR LA+ + E+ P + Sbjct: 265 PFVTAPNKFAALASHEPLVHAHGAMKTLACALMKIANDIRWLASGPRCGIGELIIP--EN 322 Query: 286 QIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAF 345 + GSS MP K NP + E + ++ S FE + L Sbjct: 323 EPGSSIMPGKVNPTQCEAMTMVCAQVLGNDTAVGIADSQGNFELNVFKPVIIFNVLHSLN 382 Query: 346 LTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHE---K 402 L AD+ + + +EG+ VI+ + L + N + KA + H Sbjct: 383 LLADSCHSFQEFCAEGIEPNQPVIDYYLHHSLMLVTALNQHIGYDKAAKIAKTAHHDNIS 442 Query: 403 IRVLSQQAASVVKQEGGDNDLIERI 427 ++ + + + ++ + E++ Sbjct: 443 LQEAAVKLGILTAEQFAEFVKPEKM 467 >1VDK-A nrPDB Length = 466 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 61/322 (18%), Positives = 111/322 (34%), Gaps = 11/322 (3%) Query: 95 FGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDL-LLPKLARVISRLADFAKERASLP 153 G ++ G +S + + AL L P + +I A+ + Sbjct: 123 LGSKYAHPNDHVNRGQSSNDTFPTAMYVAVALALHQRLYPAVEGLIRTFTAKAQAFDQIV 182 Query: 154 TLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFE 213 +G TH A T+G+ W L L +K + L + GT + L Sbjct: 183 KVGRTHLMDAVPITLGQEIGSWAAQLKTTLAAVKEMEKGLYNLAIGGT--AVGTGLNAHP 240 Query: 214 GDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLA 273 V + T F+ A + V+ + +L ++ KI D+R LA Sbjct: 241 RFGELVAKYLAEETG-LPFRVAENRFAALAAHDELVNVMGAIRTLAGALMKIGNDVRWLA 299 Query: 274 N-----LKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFE 328 + + E+ P + GSS MP K NP + E + + S F+ Sbjct: 300 SGPYAGIGEITIP--ANEPGSSIMPGKVNPTQVEALTMVVVRVYGNDHTVAFAGSQGNFQ 357 Query: 329 RTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMA 388 + L L AD + + ++++G+ + IE +++ N + Sbjct: 358 LNVYKPVMAYSTLESINLLADAVASFDAHLAQGIEPNLERIEEYLQKNPMLATALNKAIG 417 Query: 389 MVKAGGSRQDCHEKIRVLSQQA 410 KA + ++ + L Q A Sbjct: 418 YDKAAEIVKKALKEKKTLKQAA 439 >3R6Q-A nrPDB Length = 468 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 59/323 (18%), Positives = 118/323 (36%), Gaps = 28/323 (8%) Query: 112 SCYVGD---NTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTV 168 S D I + + L+ L+ + A E A + +G TH Q A + Sbjct: 138 SQSTNDAFPTATHIAVLSLLNQLIETTKYMQQEFMKKADEFAGVIKMGRTHLQDAVPILL 197 Query: 169 GKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKG-TTGTQASFLQLFEGDDHKVEQLDKMVT 227 G+ + + + D++ + R++L + GT G + E + + Sbjct: 198 GQEFEAYARVIARDIERIANTRNNLYDINMGATAVGT---------GLNADPEYISIVTE 248 Query: 228 EKAGFKRAFIITGQ-----TYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKE 277 A F + + Q T EV S L ++ KI D+RL+A+ L E Sbjct: 249 HLAKFSGHPLRSAQHLVDATQNTDCYTEVSSALKVCMINMSKIANDLRLMASGPRAGLSE 308 Query: 278 MEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANR 337 + P Q GSS MP K NP+ E +A + + + FE + + Sbjct: 309 IVLPAR--QPGSSIMPGKVNPVMPEVMNQVAFQVFGNDLTITSASEAGQFELNVMEPVLF 366 Query: 338 RICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQ 397 + + + + +N +G+ + ++ + + + + N + A + Sbjct: 367 FNLIQSISIMTNVFKSFTENCLKGIKANEERMKEYVEKSIGIITAINPHVGYETAAKLAR 426 Query: 398 DCH---EKIRVLSQQAASVVKQE 417 + + E IR L + + +++ Sbjct: 427 EAYLTGESIRELCIKYGVLTEEQ 449 >3OCE-A nrPDB Length = 474 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 53/330 (16%), Positives = 116/330 (35%), Gaps = 14/330 (4%) Query: 112 SCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKR 171 + V + L + + + L R+I+ +E A++ +G T Q A T+G+ Sbjct: 144 TNDVYPTAVRLALLLSQNQVQTALHRLIAAFEAKGREFATVIKIGRTQLQDAVPITLGQE 203 Query: 172 CCLWIQDLCMDLQNLKRVRDDLRFRGVKG-TTGTQASFLQLFEGDDHKVEQLDKMVTEKA 230 + L D L+ V R + G GT+ + + + + +L ++ Sbjct: 204 FEAFAATLREDTARLEEVAALFREVNLGGTAIGTRINASHAYA--EQAIVELSQISG--I 259 Query: 231 GFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQ 285 K + ++ + +L + + KI D+RLL++ L E+ P Sbjct: 260 ELKATGNLVEASWDTGAFVTFSGILRRIAVKLSKIANDLRLLSSGPRSGLGEIRLPAV-- 317 Query: 286 QIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAF 345 Q GSS MP K NP+ E + ++ + A + + L+ Sbjct: 318 QPGSSIMPGKVNPVIPESVNQVCYQVIGNDLTVTMAAESGQLQLNAFEPLIVYNILSSMR 377 Query: 346 LTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRV 405 L + N + +G+ + + + ++ +A + + Sbjct: 378 LLGRAMTNLAERCVDGIEANVERCRAGAEESISLATALVPVVGYARAAEIAKQALASGQT 437 Query: 406 LSQQAASVVKQEGGDNDLIERIQVDAYFSP 435 + + A S +++ +++ F P Sbjct: 438 VMEVAISKGLDASALTIMLDPLRM--AFPP 465 >1JSW-A nrPDB Length = 478 Score = 121 bits (303), Expect = 7e-28, Method: Composition-based stats. Identities = 59/353 (16%), Positives = 125/353 (35%), Gaps = 23/353 (6%) Query: 112 SCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKR 171 + I + ++L L+ + ++ A E + +G T Q A T+G+ Sbjct: 144 TNDAYPTGFRIAVYSSLIKLVDAINQLREGFERKAVEFQDILKMGRTQLQDAVPMTLGQE 203 Query: 172 CCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAG 231 + L +++N++R + L + T + L + + VT Sbjct: 204 FRAFSILLKEEVKNIQRTAELLLEVNLGAT--AIGTGLNTPKEYSPLAVKKLAEVTGFPC 261 Query: 232 FKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLAN-----LKEMEEPFEKQQ 286 +I T + V L L + KIC D+RLL++ L E+ P + Q Sbjct: 262 VPAEDLI-EATSDCGAYVMVHGALKRLAVKMSKICNDLRLLSSGPRAGLNEINLP--ELQ 318 Query: 287 IGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFL 346 GSS MP K NP+ E + ++ A + + + + + Sbjct: 319 AGSSIMPAKVNPVVPEVVNQVCFKVIGNDTTVTMAAEAGQLQLNVMEPVIGQAMFESVHI 378 Query: 347 TADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVL 406 + N L+ G+ +V E + + + N + + + + Sbjct: 379 LTNACYNLLEKCINGITANKEVCEGYVYNSIGIVTYLNPFIGHHNG--------DIVGKI 430 Query: 407 SQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQR 459 + V++ + L+ ++D FS + +L+ P+ R + + ++ Sbjct: 431 CAETGKSVREVVLERGLLTEAELDDIFS-----VQNLMHPAYKAKRYTDESEQ 478 >1TJU-A nrPDB Length = 474 Score = 117 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 72/441 (16%), Positives = 156/441 (35%), Gaps = 36/441 (8%) Query: 19 SRY---ASPEMCFVFSDRYKFRTWRQLWL----WLAEAEQTLGLPITDEQIQEMKSNLEN 71 R+ P M + S + ++ + A+A + G+ +T +++++ S LE Sbjct: 13 GRFSGSTDPIMEKLNSSIAYDQRLSEVDIQGSMAYAKALEKAGI-LTKTELEKILSGLEK 71 Query: 72 IDFKMAAEE--EKRLRHDV-MAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNAL 128 I + + K+ D+ A+ AG +H G + + ++N+L Sbjct: 72 ISEEWSKGVFVVKQSDEDIHTANERRLKELIGDIAGKLHTGRSRNDQVVTDLKLFMKNSL 131 Query: 129 DLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKR 188 ++ L ++I L + A + G++H Q AQ + L D + L Sbjct: 132 SIISTHLLQLIKTLVERAAIEIDVILPGYSHLQKAQPIRWSQFLLSHAVALTRDSERLGE 191 Query: 189 VRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVD 248 V+ + + +G A + ++ + E A + R Sbjct: 192 VKKRINVLPLG--SGALAGNPLDID------REMLRSELEFASI--SLNSMDAISERDFV 241 Query: 249 IEVLSVLASLGASVHKICTD--IRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCS 306 +E LS L + K+ D I + + + GSS MP K+NP E S Sbjct: 242 VEFLSFATLLMIHLSKMAEDLIIYSTSEFGFLTL-SDAFSTGSSLMPQKKNPDSLELIRS 300 Query: 307 LARHLMTLVMDPLQ--TASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVV 364 A + + L + + L + + + + T +L + L + Sbjct: 301 KAGRVFGRLASILMVLKGLPSTYNKDLQE---DKEAVFDVVDTLTAVLQVATGVISTLQI 357 Query: 365 YPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLI 424 + +E+ + P M ++ + +V+ G + H S +A + + +G + + Sbjct: 358 SKENMEKALT---PEMLATDLALYLVRKGVPFRQAH----TASGKAVHLAETKGITINKL 410 Query: 425 ERIQVDAYFSPIHSQLDHLLD 445 + + S + + + Sbjct: 411 SLEDLKSISPQFSSDVSQVFN 431 >1TJ7-A nrPDB Length = 457 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 74/430 (17%), Positives = 142/430 (33%), Gaps = 37/430 (8%) Query: 42 LWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHT-FGHCCP 100 + +A+ L + E ++ + D + D+ + V Sbjct: 49 VLTAEEQAQLEEALNVLLEDVRARPQQILESDAE-----------DIHSWVEGKLIDKVG 97 Query: 101 KAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHF 160 + +H G + + ++ + LL ++ S L + A+ G+TH Sbjct: 98 QLGKKLHTGRSRNDQVATDLKLWCKDTVSELLTANRQLQSALVETAQNNQDAVMPGYTHL 157 Query: 161 QPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVE 220 Q AQ T C +++ L D L+ L + G A + Sbjct: 158 QRAQPVTFAHWCLAYVEMLARDESRLQDALKRLDVSPLG--CGALAGTAYEID------- 208 Query: 221 QLDKMVTEKAGFKRAF-IITGQTYTRKVDIEVLSVLASLGASVHKICTD-IRLLANLKEM 278 + + GF A R +E+LS A + + D I Sbjct: 209 --REQLAGWLGFASATRNSLDSVSDRDHVLELLSAAAIGMVHLSRFAEDLIFFNTGEAGF 266 Query: 279 EEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTL---VMDPLQTASVQWFERTLDDSA 335 E ++ GSS MP K+NP E + +M L+ + + + D Sbjct: 267 VELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNK----DMQ 322 Query: 336 NRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGS 395 + L +A T L+ + +G+ V + +Q + + +V G Sbjct: 323 EDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCQEAAQQ--GYANATELADYLVAKGVP 380 Query: 396 RQDCHEKIRVLSQQAASVVK--QEGGDNDLIERIQV-DAYFSPIHSQLDHLLDPSSFTGR 452 ++ H + +A K ++ ++L + QV D PI S L ++ G Sbjct: 381 FREAHHIVGEAVVEAIRQGKPLEDLPLSELQKFSQVIDEDVYPILSLQSCLDKRAAKGGV 440 Query: 453 ASQQVQRFLE 462 + QQV + + Sbjct: 441 SPQQVAQAIA 450 >2E9F-A nrPDB Length = 462 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 79/442 (17%), Positives = 147/442 (33%), Gaps = 36/442 (8%) Query: 39 WRQ-LWLWLAEAEQTLGLPI-TDEQIQEMKSNLENIDFKMAA-----EEEKRLRHDVMAH 91 WR+ LW A + + + E+++ + L+ I+ ++ A EE H M Sbjct: 32 WREDLWQNRVHARMLHAVGLLSAEELEAILKGLDRIEEEIEAGTFPWREELEDVH--MNL 89 Query: 92 VHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERAS 151 G +H + + LR A+D LL L + L A++ Sbjct: 90 EARLTELVGPPGGKLHTARSRNDQVATDLRLYLRGAIDELLALLLALRRVLVREAEKHLD 149 Query: 152 --LPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFL 209 G+TH Q AQ + + + L D L+ ++ L + F Sbjct: 150 PLYVLPGYTHLQRAQPVLLAHWFLAYYEMLKRDAGRLEDAKERLNESPLGAAALAGTGFP 209 Query: 210 QLFEGDDHKVEQLDKMVTEKAGFKRAF-IITGQTYTRKVDIEVLSVLASLGASVHKICTD 268 + GFK +R +EVLS L + ++ + Sbjct: 210 IDRH-----------FTARELGFKAPMRNSLDAVASRDFALEVLSALNIGMLHLSRMAEE 258 Query: 269 IRLLA--NLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVM--DPLQTASV 324 + L + +E P + GSS MP K+NP E + A ++ + + Sbjct: 259 LILYSTEEFGFVEVP-DAFATGSSIMPQKKNPDILELIRAKAGRVLGAFVGLSAVVKGLP 317 Query: 325 QWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATEN 384 + + L + + L +A T L L + GL + + R E + Sbjct: 318 LAYNKDLQE---DKEPLLDALATYRDSLRLLAALLPGLKWRRERMWR--AAEGGYTLATE 372 Query: 385 IIMAMVKAGGSRQDCHEKIRVLSQ---QAASVVKQEGGDNDLIERIQVDAYFSPIHSQLD 441 + + + G ++ H + L + + +K + P+ Sbjct: 373 LADYLAEKGLPFREAHHVVGRLVRRLVEEGRALKDLTLEELQAHHPLFAEDALPLLRLET 432 Query: 442 HLLDPSSFTGRASQQVQRFLEE 463 + S+ G A + V+ LEE Sbjct: 433 AIHRRRSYGGTAPEAVRERLEE 454 >1I0A-A nrPDB Length = 466 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 64/425 (15%), Positives = 146/425 (34%), Gaps = 29/425 (6%) Query: 27 CFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAAEEEKRLRH 86 + +++ Q + A+A + + +T +++++ S LE I + + + Sbjct: 26 SSISTEQRLTEVDIQASMAYAKALEKASI-LTKTELEKILSGLEKISEESSKGVLVMTQS 84 Query: 87 D---VMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLA 143 D A AG + G + ++L++++ ++ L ++I L Sbjct: 85 DEDIQTAIERRLKELIGDIAGKLQTGRSRNEQVVTDLKLLLKSSISVISTHLLQLIKTLV 144 Query: 144 DFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTG 203 + A + G+TH Q A + L D + L V+ + + +G Sbjct: 145 ERAAIEIDIIMPGYTHLQKALPIRWSQFLLSHAVALTRDSERLGEVKKRITVLPLG--SG 202 Query: 204 TQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVH 263 A L + +LD R +E++SV L + Sbjct: 203 VLAG-NPLEIDRELLRSELDMT-------SITLNSIDAISERDFVVELISVATLLMIHLS 254 Query: 264 KICTD--IRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQ- 320 K+ D I + + GSS +P K+NP E S A + + L Sbjct: 255 KLAEDLIIFSTTEFGFVTL-SDAYSTGSSLLPQKKNPDSLELIRSKAGRVFGRLAAILMV 313 Query: 321 -TASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPF 379 F + L + + + + T +L + L + + +E+ + P Sbjct: 314 LKGIPSTFSKDLQE---DKEAVLDVVDTLTAVLQVATGVISTLQINKENMEKALT---PE 367 Query: 380 MATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQ 439 + + ++ + +V+ G + + S +A + + +G + + + + S Sbjct: 368 LLSTDLALYLVRKGMPIRQA----QTASGKAVHLAETKGITINNLTLEDLKSISPLFASD 423 Query: 440 LDHLL 444 + + Sbjct: 424 VSQVF 428 >6G3D-A nrPDB Length = 508 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 57/363 (15%), Positives = 122/363 (33%), Gaps = 20/363 (5%) Query: 89 MAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKE 148 + + AG +H+G + + + + LR+ L + + + A + Sbjct: 89 LPYEAALKRTIGSVAGKMHIGRSRNDLANAGKRMFLRDQLLRTIEAVIGYREAVVHKAAD 148 Query: 149 RASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASF 208 + +T + AQ T+G ++L +L + + + + G T + Sbjct: 149 HLDTVMVVYTQRKEAQPITLGHYLMAISENLAKNLDRYRELYARINLCPL-GAAATAGTG 207 Query: 209 LQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTD 268 L + D +V + E V A + + ++ ++ Sbjct: 208 WPLNRDRTSALLGFDGLVVNSIEGVAGW---------DHVAEHAFVNAVFLSGLSRLASE 258 Query: 269 IRLLANLKE-MEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWF 327 I+L + + + E SS MP K+NP ER A M ++ L + + + Sbjct: 259 IQLWSTDEYQVAELDASFAGTSSIMPQKKNPDSLERSRKAAFAAMGPLVGILTSLNAIEY 318 Query: 328 ERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIM 387 + SA R + + + + L + + + + M T+ M Sbjct: 319 Q----YSAARVELEPRSIDALIAATHAMTGVVRTLHPNKERMRQYAAENYSTM-TDLTDM 373 Query: 388 AMVKAGGSRQDCHEKIRVLSQQA-ASVVKQEGGDNDLIER---IQVDAYFSPIHSQLDHL 443 + + G ++ HE + + A +K DL++ Q A + + Sbjct: 374 LVRRVGIDYREAHEIVAHVVITAIEKGIKANKIGLDLVQEAAVAQTGAGINVSADDIKDA 433 Query: 444 LDP 446 LDP Sbjct: 434 LDP 436 >1AOS-A nrPDB Length = 464 Score = 97.1 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 65/382 (17%), Positives = 125/382 (32%), Gaps = 25/382 (6%) Query: 27 CFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIQEMKSNLENIDFKMAAEEEKRLRH 86 + DR+ + Q + + GL +T ++ ++ L+ + + A K + Sbjct: 26 ASIAYDRHLWEVDVQGSKAYSRGLEKAGL-LTKAEMDQILHGLDKVAEEWAQGTFKLNSN 84 Query: 87 DV---MAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLA 143 D A+ AG +H G + + +R L L +I + Sbjct: 85 DEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMV 144 Query: 144 DFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTG 203 D A+ + G+TH Q AQ L D + L VR + + +G Sbjct: 145 DRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLG--SG 202 Query: 204 TQASFLQLFEGDDHKVEQLDKMVTEKAGF-KRAFIITGQTYTRKVDIEVLSVLASLGASV 262 A + +++ + F T R E L + + Sbjct: 203 AIAGNPLGVD---------RELLRAELNFGAITLNSMDATSERDFVAEFLFWRSLCMTHL 253 Query: 263 HKICTDIRLL-ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQT 321 ++ D+ L + + GSS MP K+NP E S A + L T Sbjct: 254 SRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMT 313 Query: 322 --ASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPF 379 + + L + + + E T +L + L ++ + + + + P Sbjct: 314 LKGLPSTYNKDLQE---DKEAVFEVSDTMSAVLQVATGVISTLQIHQENMGQALS---PD 367 Query: 380 MATENIIMAMVKAGGSRQDCHE 401 M ++ +V+ G + HE Sbjct: 368 MLATDLAYYLVRKGMPFRQAHE 389 >6IG5-A nrPDB Length = 470 Score = 77.9 bits (190), Expect = 9e-15, Method: Composition-based stats. Identities = 57/326 (17%), Positives = 101/326 (30%), Gaps = 24/326 (7%) Query: 83 RLRHDVMAHVH--TFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVIS 140 DV A + P G + G + + LR+A+ + + V+ Sbjct: 83 VTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVG 142 Query: 141 RLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKG 200 LA+ A S G TH Q AQ + L DL + Sbjct: 143 ALAEQAAAHPSAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPYG- 201 Query: 201 TTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFK-RAFIITGQTYTRKVDIEVLSVLASLG 259 +G A + D + GF A T R E V A + Sbjct: 202 -SGALAGSSLGLDPDA---------IAADLGFSAAADNSVDATAARDFAAEAAFVFAMIA 251 Query: 260 ASVHKICTDI--RLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMD 317 + ++ DI + + GSS MP K+NP +E + L+ + Sbjct: 252 VDLSRLAEDIIVWSSTEFGYVTL-HDSWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAG 310 Query: 318 PLQTASVQ--WFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQ 375 L T Q + R L + + + ++ + +L + + L + + Sbjct: 311 LLATLKAQPLAYNRDLQE---DKEPVFDSVAQLELLLPAMAGLVASLTFNVQRMAEL--A 365 Query: 376 ELPFMATENIIMAMVKAGGSRQDCHE 401 + ++ +V+ G + HE Sbjct: 366 PAGYTLATDLAEWLVRQGVPFRSAHE 391 >3H2Z-A nrPDB Length = 382 Score = 37.4 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 25/117 (21%), Positives = 42/117 (35%), Gaps = 3/117 (2%) Query: 297 NPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLD--DSANRRICLAEAFLTADTILNT 354 N + E L VM+ L + W E + DSA RI A T D + T Sbjct: 116 NIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVT 175 Query: 355 LQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAA 411 ++ SE + V + + T+N++ + + + H L + A Sbjct: 176 VETFSEWI-VDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAG 231 >1GFN-A nrPDB Length = 334 Score = 32.8 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 35/103 (33%), Gaps = 5/103 (4%) Query: 157 FTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDD 216 T+ Q AQ GK+ W L D N+ + R T + G Sbjct: 190 RTNLQEAQPLGNGKKAEQWATGLKYDANNIYLAANYGETRNATPITNKFTN----TSGFA 245 Query: 217 HKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLG 259 +K + + + + F I T ++ D+E + + + Sbjct: 246 NKTQDVLLVAQYQFDFGLRPSIAY-TKSKAKDVEGIGDVDLVN 287 >4YWO-A nrPDB Length = 462 Score = 31.7 bits (70), Expect = 0.84, Method: Composition-based stats. Identities = 14/58 (24%), Positives = 22/58 (37%), Gaps = 1/58 (1%) Query: 87 DVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLI-ILRNALDLLLPKLARVISRLA 143 V A +AA I GAT + D + + +L L+ +SRL+ Sbjct: 402 GVHAVGENVAEMIGEAALAIRFGATVHDLIDTVHMFPTIAESLRLVALAFRSDVSRLS 459 >1H2B-A nrPDB Length = 359 Score = 31.3 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 31/76 (40%), Gaps = 6/76 (7%) Query: 129 DLLLPKLAR---VISRLADFAKERASLPTL-GFTH--FQPAQLTTVGKRCCLWIQDLCMD 182 D+ P+L VI R+A L + G H QP T+G +I+++ Sbjct: 32 DVDYPRLEGRFDVIVRIAGAGVCHTDLHLVQGMWHELLQPKLPYTLGHENVGYIEEVAEG 91 Query: 183 LQNLKRVRDDLRFRGV 198 ++ L++ + V Sbjct: 92 VEGLEKGDPVILHPAV 107 >4UEJ-A nrPDB Length = 346 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 11/72 (15%), Positives = 27/72 (37%), Gaps = 1/72 (1%) Query: 115 VGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCL 174 V D ++ + ++ + V ++A + LP + F + T+G Sbjct: 5 VNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRI-FKNGAHYYPITLGHEFSG 63 Query: 175 WIQDLCMDLQNL 186 +I + + +L Sbjct: 64 YIDAVGSGVDDL 75 >5Z3D-A nrPDB Length = 405 Score = 29.7 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 39/148 (26%), Gaps = 24/148 (16%) Query: 127 ALDLLLPKLARVISRLADFAKERASLPTLGFTH-FQPAQLTTVGKRCCLWIQDLCMDLQN 185 A+D LL R + E + TLG H A T R W Sbjct: 181 AVDYLLAFWDRPCYDWWEEHVEHRHVSTLGAIHGGLVAVGTCAALRSAPWSAATLQVAAR 240 Query: 186 LKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFI----ITGQ 241 + R + G L + G L V G +T Sbjct: 241 I---------RSLVSAEGVVDGHLVKWLGSSAVDGSLPACVV-PFGLVPPDDDVAAMTRA 290 Query: 242 TYTRKVDIEVLSVLASLGASVHKICTDI 269 + +D++ VH+ D+ Sbjct: 291 AVAKDLDVD---------GGVHRFAADV 309 >1XKW-A nrPDB Length = 665 Score = 29.3 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 5/28 (17%), Positives = 10/28 (35%) Query: 259 GASVHKICTDIRLLANLKEMEEPFEKQQ 286 G + D + E+ +P +Q Sbjct: 426 GGLIWDFARDWSWYVSYAEVYQPQADRQ 453 >6B2E-B nrPDB Length = 272 Score = 29.3 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 15/98 (15%), Positives = 34/98 (34%), Gaps = 4/98 (4%) Query: 170 KRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGT----TGTQASFLQLFEGDDHKVEQLDKM 225 K W QDL ++ ++ R + G +G+ ++ + + + Sbjct: 57 KEFVSWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAIL 116 Query: 226 VTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVH 263 + + F + GQ + V S L ++ +H Sbjct: 117 DLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIH 154 >5VFB-A nrPDB Length = 728 Score = 29.3 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 27/78 (34%) Query: 70 ENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALD 129 E + K V+A F H+ ATS V + ++ L+N + Sbjct: 153 EEGGAEKGKGYNKVRGDKVIAFARAFLDEAAPLESGSHVDATSYSVKNGALVVALKNGSE 212 Query: 130 LLLPKLARVISRLADFAK 147 L + ++ D AK Sbjct: 213 TGLKNAGQFLAFQGDAAK 230 >4IMM-A nrPDB Length = 399 Score = 29.3 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 25/89 (28%) Query: 78 AEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLAR 137 A DV+A G + + + G T+ + + + +L + Sbjct: 298 AVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNPVTIGTYIAVGDADGVVHILNHQGQ 357 Query: 138 VISRLADFAKERASLPTLGFTHFQPAQLT 166 +ISR + Q A Sbjct: 358 IISRANTKGALTNLTVINNRLYAQSADGV 386 >3ORP-A nrPDB Length = 311 Score = 28.6 bits (62), Expect = 6.3, Method: Composition-based stats. Identities = 19/138 (13%), Positives = 44/138 (31%), Gaps = 16/138 (11%) Query: 8 GSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWL-AEAEQTLGLPITDEQIQEMK 66 GS + S L+ RY E+ F ++ L + + + + + Sbjct: 1 GSHMTTPSHLSDRYELGEIL-------GFGGMSEVHLARDLRDHRDVAVKVLRADLARDP 53 Query: 67 SNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHL------GATSCYVGDNTD 120 S + A+ L H + V+ G A + ++ G T + Sbjct: 54 SFYLRF--RREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG 111 Query: 121 LIILRNALDLLLPKLARV 138 + + A++++ + Sbjct: 112 PMTPKRAIEVIADACQAL 129 >3BJE-A nrPDB Length = 349 Score = 28.6 bits (62), Expect = 7.0, Method: Composition-based stats. Identities = 20/83 (24%), Positives = 30/83 (36%), Gaps = 3/83 (3%) Query: 189 VRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVD 248 +R R ++ TGT V+ ++ ++ E K + GQ RK D Sbjct: 67 IRASRDHREIRFATGTYKGTPVTVISTGMGVDNIEIVLNEIHALKEYDMERGQWRHRKGD 126 Query: 249 IEVLSVLASLGASVHKICTDIRL 271 + S S KI IRL Sbjct: 127 ADAPSAGPFFDPSTMKI---IRL 146 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.126 0.316 Lambda K H 0.267 0.0390 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,338,706 Number of Sequences: 36641 Number of extensions: 527088 Number of successful extensions: 1939 Number of sequences better than 10.0: 60 Number of HSP's better than 10.0 without gapping: 80 Number of HSP's successfully gapped in prelim test: 23 Number of HSP's that attempted gapping in prelim test: 1653 Number of HSP's gapped (non-prelim): 110 length of query: 484 length of database: 10,336,785 effective HSP length: 101 effective length of query: 383 effective length of database: 6,636,044 effective search space: 2541604852 effective search space used: 2541604852 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.2 bits)