BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P29350 (595 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3PS5-A nrPDB 1244 0.0 2B3O-A nrPDB 1117 0.0 4H1O-A nrPDB 641 0.0 4HJQ-A nrPDB 602 e-172 6CMQ-A nrPDB 497 e-141 4PVG-A nrPDB 358 3e-99 2C7S-A nrPDB 207 7e-54 2OOQ-A nrPDB 207 9e-54 4BPC-A nrPDB 202 3e-52 2JJD-A nrPDB 199 3e-51 2NV5-A nrPDB 198 6e-51 1RPM-A nrPDB 196 4e-50 6D4D-A nrPDB 194 7e-50 1LAR-A nrPDB 194 9e-50 5HDE-A nrPDB 192 4e-49 2H03-A nrPDB 191 5e-49 2PI7-A nrPDB 191 6e-49 1YFO-A nrPDB 191 8e-49 2PBN-A nrPDB 191 1e-48 2NLK-A nrPDB 190 1e-48 5AWX-A nrPDB 189 4e-48 4BJO-A nrPDB 189 4e-48 2I75-A nrPDB 185 4e-47 1WCH-A nrPDB 185 4e-47 2GJT-A nrPDB 184 7e-47 3OLR-A nrPDB 182 4e-46 3I36-A nrPDB 181 7e-46 1YGU-A nrPDB 181 1e-45 3S3F-A nrPDB 181 1e-45 4GE6-A nrPDB 180 1e-45 4GFV-A nrPDB 179 3e-45 2BZL-A nrPDB 179 4e-45 1ZC0-A nrPDB 179 4e-45 5OVR-A nrPDB 178 6e-45 6H8S-A nrPDB 175 5e-44 1L8K-A nrPDB 175 5e-44 2CFV-A nrPDB 175 6e-44 2QEP-A nrPDB 175 6e-44 2A8B-A nrPDB 169 3e-42 4IKC-A nrPDB 164 9e-41 2I1Y-A nrPDB 163 2e-40 4RHG-A nrPDB 162 3e-40 1P15-A nrPDB 159 2e-39 6D3F-A nrPDB 149 2e-36 4AZ1-A nrPDB 104 1e-22 3M4U-A nrPDB 95 8e-20 1AD5-A nrPDB 53 4e-07 1GRI-A nrPDB 52 5e-07 2CRH-A nrPDB 52 6e-07 2FO0-A nrPDB 52 7e-07 3T04-A nrPDB 52 7e-07 4XEY-B nrPDB 52 7e-07 2LCT-A nrPDB 52 7e-07 6AMW-A nrPDB 52 8e-07 2ABL-A nrPDB 51 1e-06 2AUG-A nrPDB 51 1e-06 1K9A-A nrPDB 49 5e-06 2PLE-A nrPDB 47 2e-05 1MIL-A nrPDB 47 3e-05 3RO1-A nrPDB 46 5e-05 2KK6-A nrPDB 46 6e-05 2LQW-A nrPDB 45 7e-05 6DR7-A nrPDB 45 9e-05 4M4Z-A nrPDB 44 2e-04 5U06-A nrPDB 43 4e-04 4FL3-A nrPDB 43 5e-04 2EKX-A nrPDB 42 5e-04 2EOB-A nrPDB 42 7e-04 6F3F-A nrPDB 42 7e-04 1A81-A nrPDB 42 9e-04 1NRV-A nrPDB 42 0.001 2H8H-A nrPDB 42 0.001 4XI2-A nrPDB 41 0.001 3F41-A nrPDB 41 0.001 2CS0-A nrPDB 40 0.002 2EYZ-A nrPDB 40 0.003 4GL9-E nrPDB 39 0.008 6C7Y-B nrPDB 39 0.009 4ERC-A nrPDB 38 0.010 2HMH-A nrPDB 38 0.010 5Z59-A nrPDB 38 0.012 2BBU-A nrPDB 38 0.012 5K23-A nrPDB 38 0.013 1OHC-A nrPDB 38 0.016 3S4O-A nrPDB 37 0.023 2HDV-A nrPDB 37 0.031 6C5X-D nrPDB 37 0.033 3CXL-A nrPDB 36 0.037 5K22-A nrPDB 36 0.042 1KA6-A nrPDB 35 0.081 5XW4-A nrPDB 35 0.083 5M6U-B nrPDB 35 0.091 4NX8-A nrPDB 35 0.10 1M27-A nrPDB 35 0.11 2RF6-A nrPDB 35 0.13 1RPY-A nrPDB 34 0.23 1V3A-A nrPDB 33 0.24 2OZ5-A nrPDB 33 0.37 2WGP-A nrPDB 33 0.42 3D1Q-A nrPDB 33 0.45 5LXQ-B nrPDB 32 0.56 2VIF-A nrPDB 32 0.60 3RZ2-A nrPDB 32 0.79 4R0S-A nrPDB 32 0.81 1ZCK-A nrPDB 32 0.83 1G4W-R nrPDB 32 0.83 4JGH-A nrPDB 32 0.86 2R0B-A nrPDB 32 1.1 1YN9-A nrPDB 31 1.6 2M3V-A nrPDB 30 2.3 5IXI-A nrPDB 30 2.3 2IZV-A nrPDB 30 2.6 6D67-A nrPDB 30 3.1 1XA6-A nrPDB 30 4.0 4CRV-B nrPDB 30 4.0 2Q4W-A nrPDB 28 8.8 2FZ4-A nrPDB 28 9.7 >3PS5-A nrPDB Length = 595 Score = 1244 bits (3219), Expect = 0.0, Method: Compositional matrix adjust. Identities = 594/595 (99%), Positives = 594/595 (99%) Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 Query: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120 Query: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG Sbjct: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180 Query: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA Sbjct: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240 Query: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD Sbjct: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300 Query: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK Sbjct: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360 Query: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH Sbjct: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420 Query: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVH SAGIGRTGTIIVIDMLMENISTKGLDC Sbjct: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHSSAGIGRTGTIIVIDMLMENISTKGLDC 480 Query: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT 540 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT Sbjct: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT 540 Query: 541 YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK 595 YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK Sbjct: 541 YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK 595 >2B3O-A nrPDB Length = 532 Score = 1117 bits (2889), Expect = 0.0, Method: Compositional matrix adjust. Identities = 532/532 (100%), Positives = 532/532 (100%) Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 Query: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120 Query: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG Sbjct: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180 Query: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA Sbjct: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240 Query: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD Sbjct: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300 Query: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK Sbjct: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360 Query: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH Sbjct: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420 Query: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC Sbjct: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480 Query: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ 532 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ Sbjct: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ 532 >4H1O-A nrPDB Length = 560 Score = 641 bits (1653), Expect = 0.0, Method: Compositional matrix adjust. Identities = 313/533 (58%), Positives = 403/533 (75%), Gaps = 6/533 (1%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 RWFH +++G++AE LL RGV GSFLARPS+ N GDF+LSVR VTHI+IQN+G +YD Sbjct: 26 RWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGGYYD 85 Query: 63 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAET 122 LYGGEKFATL ELV+YY + G L++++G +I LKYPLNC+DPTSERW+HGH+SG +AE Sbjct: 86 LYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEK 145 Query: 123 LLQAKGEPWTFLVRESLSQPGDFVLSVLS--DQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180 LL KG+ +FLVRES S PGDFVLSV + D+ ++ G +VTH+ + C+ +Y VGG Sbjct: 146 LLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKS-KVTHVMIRCQELKYDVGG 204 Query: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240 E FDSLTDLVEH+KK + E G + L+QP TR+NAA+IE+RV EL+K E+ D Sbjct: 205 GERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKV 264 Query: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300 K GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNILPFDH+RV+L D N P SD Sbjct: 265 KQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSD 324 Query: 301 YINANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKG 357 YINAN I + N+K +YIA+QGCL+ TVNDFW+M +QENSRVIVMTT+EVE+G Sbjct: 325 YINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG 384 Query: 358 RNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSW 417 ++KCV YWP+ + YG V N E +Y LR L++S + G+ R +W Y + +W Sbjct: 385 KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW 444 Query: 418 PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477 PDHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGIGRTGT IVID+L++ I KG Sbjct: 445 PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG 504 Query: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQK 530 +DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IET ++++E Q K Sbjct: 505 VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSK 557 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 44/119 (36%), Positives = 66/119 (55%), Gaps = 16/119 (13%) Query: 106 TSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 TS RW+H +++G +AE LL +G +FL R S S PGDF LSV + VT Sbjct: 23 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGA---------VT 73 Query: 166 HIKVMCEGGRYTVGGLETFDSLTDLVEHFKK--TGIEEASGAFVYLRQPYYATRVNAAD 222 HIK+ GG Y + G E F +L +LV+++ + ++E +G + L+ P +N AD Sbjct: 74 HIKIQNTGGYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYP-----LNCAD 127 >4HJQ-A nrPDB Length = 308 Score = 602 bits (1553), Expect = e-172, Method: Compositional matrix adjust. Identities = 285/287 (99%), Positives = 286/287 (99%) Query: 242 AGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDY 301 +GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDY Sbjct: 22 SGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDY 81 Query: 302 INANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKC 361 INANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKC Sbjct: 82 INANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKC 141 Query: 362 VPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHG 421 VPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHG Sbjct: 142 VPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHG 201 Query: 422 VPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCD 481 VPSEPGGVLSFLDQINQRQESLPHAGPIIVH SAGIGRTGTIIVIDMLMENISTKGLDCD Sbjct: 202 VPSEPGGVLSFLDQINQRQESLPHAGPIIVHSSAGIGRTGTIIVIDMLMENISTKGLDCD 261 Query: 482 IDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQS 528 IDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQS Sbjct: 262 IDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQS 308 >6CMQ-A nrPDB Length = 427 Score = 497 bits (1279), Expect = e-141, Method: Compositional matrix adjust. Identities = 246/425 (57%), Positives = 318/425 (74%), Gaps = 6/425 (1%) Query: 104 DPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLS--DQPKAGPGSP 161 DPTSERW+HGH+SG +AE LL KG+ +FLVRES S PGDFVLSV + D+ ++ G Sbjct: 4 DPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKS 63 Query: 162 LRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAA 221 +VTH+ + C+ +Y VGG E FDSLTDLVEH+KK + E G + L+QP TR+NAA Sbjct: 64 -KVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAA 122 Query: 222 DIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILP 281 +IE+RV EL+K E+ D K GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNILP Sbjct: 123 EIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILP 182 Query: 282 FDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQM 338 FDH+RV+L D N P SDYINAN I + N+K +YIA+QGCL+ TVNDFW+M Sbjct: 183 FDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRM 242 Query: 339 AWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVS 398 +QENSRVIVMTT+EVE+G++KCV YWP+ + YG V N E +Y LR L++S Sbjct: 243 VFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLS 302 Query: 399 PLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIG 458 + G+ R +W Y + +WPDHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGIG Sbjct: 303 KVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIG 362 Query: 459 RTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET 518 RTGT IVID+L++ I KG+DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IET Sbjct: 363 RTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET 422 Query: 519 TKKKL 523 ++++ Sbjct: 423 LQRRI 427 Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 52/111 (46%), Positives = 69/111 (62%), Gaps = 12/111 (10%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGD----------QVTHI 52 RWFH LSG +AE LL +G HGSFL R S+ + GDF LSVR GD +VTH+ Sbjct: 9 RWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHV 68 Query: 53 RIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCS 103 I+ YD+ GGE+F +LT+LVE+Y + V + GT++ LK PLN + Sbjct: 69 MIRCQELKYDVGGGERFDSLTDLVEHYKKNPMV--ETLGTVLQLKQPLNTT 117 >4PVG-A nrPDB Length = 298 Score = 358 bits (920), Expect = 3e-99, Method: Compositional matrix adjust. Identities = 174/290 (60%), Positives = 222/290 (76%), Gaps = 3/290 (1%) Query: 238 DTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIP 297 D K GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNILPFDH+RV+L D N P Sbjct: 3 DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP 62 Query: 298 GSDYINANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREV 354 SDYINAN I + N+K +YIA+QGCL+ TVNDFW+M +QENSRVIVMTT+EV Sbjct: 63 VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV 122 Query: 355 EKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQY 414 E+G++KCV YWP+ + YG V N E +Y LR L++S + G+ R +W Y + Sbjct: 123 ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF 182 Query: 415 LSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENIS 474 +WPDHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGIGRTGT IVID+L++ I Sbjct: 183 RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR 242 Query: 475 TKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLE 524 KG+DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IET +++LE Sbjct: 243 EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRLE 292 >2C7S-A nrPDB Length = 313 Score = 207 bits (528), Expect = 7e-54, Method: Compositional matrix adjust. Identities = 116/272 (42%), Positives = 161/272 (59%), Gaps = 17/272 (6%) Query: 243 GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302 GF EE+ES + + + ++ +N+ KNRY NI+ +DHSRVILQ + + P SDYI Sbjct: 45 GFKEEYESFFEGQSASWDV---AKKDQNRAKNRYGNIIAYDHSRVILQPVEDD-PSSDYI 100 Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362 NANYI + YIA+QG + TV DFW+M WQE S IVM T VE GR KC Sbjct: 101 NANYIDGY-----QRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCY 155 Query: 363 PYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422 YWP+ YG + VT EY +RT + + IRE+ + + WPDHGV Sbjct: 156 KYWPD--DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE-IREVKQFHFTGWPDHGV 212 Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482 P G+LSF+ ++ + + P AGPI+VHCSAG GRTG IVID++++ +G+ + Sbjct: 213 PYHATGLLSFIRRV--KLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV---V 267 Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514 DI ++ +R++R MVQTE QY FI+ AI + Sbjct: 268 DIYNCVKALRSRRINMVQTEEQYIFIHDAILE 299 >2OOQ-A nrPDB Length = 286 Score = 207 bits (528), Expect = 9e-54, Method: Compositional matrix adjust. Identities = 122/297 (41%), Positives = 168/297 (56%), Gaps = 23/297 (7%) Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYK 277 + AD+ + ++ + Q GF EE+E+L + + + + EN+ KNRY Sbjct: 4 IRVADLLQHITQMKRGQ------GYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYG 54 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 NI+ +DHSRV L D + P SDYINANYI + YIA+QG ++ TV DFW+ Sbjct: 55 NIISYDHSRVRLLVLDGD-PHSDYINANYIDGY-----HRPRHYIATQGPMQETVKDFWR 108 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQV 397 M WQENS IVM T VE GR KCV YWP+ YG VT EY +RT V Sbjct: 109 MIWQENSASIVMVTNLVEVGRVKCVRYWPD--DTEVYGDIKVTLIETEPLAEYVIRTFTV 166 Query: 398 SPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGI 457 + IRE+ + + SWPDHGVP G+L F+ Q+ + + P AGPI+VHCSAG Sbjct: 167 QKKGYHE-IRELRLFHFTSWPDHGVPCYATGLLGFVRQV--KFLNPPEAGPIVVHCSAGA 223 Query: 458 GRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514 GRTG I ID +++ +G+ +DI ++ +RAQR +VQTE QY F++ AI + Sbjct: 224 GRTGCFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 277 >4BPC-A nrPDB Length = 582 Score = 202 bits (515), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 118/292 (40%), Positives = 164/292 (56%), Gaps = 30/292 (10%) Query: 225 NRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDH 284 N L+L+++ ES D + WE H LE NK KNRY N++ +DH Sbjct: 22 NDSLKLSQEYESIDPGQQFTWE-------------HSNLE----VNKPKNRYANVIAYDH 64 Query: 285 SRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENS 344 SRVILQ + I GSDYINANY+ YIA+QG L T DFW+M W++ S Sbjct: 65 SRVILQPIE-GIMGSDYINANYVDGY-----RRQNAYIATQGPLPETFGDFWRMVWEQRS 118 Query: 345 RVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGD 404 IVM TR EK R KC YWP G + YG VT + + +RT + + + Sbjct: 119 ATIVMMTRLEEKSRIKCDQYWPNRGTE-TYGFIQVTLLDTIELATFAVRTFSLHKNGSSE 177 Query: 405 LIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTII 464 RE+ +Q+ +WPDHGVP P L+FL ++ + + P AGPI+VHCSAG+GRTG I Sbjct: 178 K-REVRQFQFTAWPDHGVPEYPTPFLAFLRRV--KTANPPDAGPIVVHCSAGVGRTGAFI 234 Query: 465 VIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 VID ++E I + +D+ + ++R+QR+ MVQTE QY FI+ A+ + + Sbjct: 235 VIDAMLERIKP---EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 283 Score = 192 bits (488), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 99/254 (38%), Positives = 148/254 (58%), Gaps = 11/254 (4%) Query: 263 LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI 322 + P NK KNR NI+P++ +RV LQ + GSDYINA++I K YI Sbjct: 332 ISANLPANKFKNRLVNIMPYESTRVALQP-IRGVEGSDYINASFIDGY-----RQQKAYI 385 Query: 323 ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNC 382 A+QG L T DFW+M W+ NS ++VM T+ E GR KC YWP R Y + V Sbjct: 386 ATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPM 444 Query: 383 GEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES 442 E++ +Y LR +V+ +G R + +Q+ WP+ GVP G + F+ Q+++ +E Sbjct: 445 AEYNMPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ 503 Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTE 502 GPI VHCSAG+GRTG I + +++E + +G+ +DI +T++M+R QR MVQTE Sbjct: 504 FGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTE 560 Query: 503 AQYKFIYVAIAQFI 516 +Y+F Y A +++ Sbjct: 561 DEYQFAYQAALEYL 574 >2JJD-A nrPDB Length = 599 Score = 199 bits (506), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 126/316 (39%), Positives = 170/316 (53%), Gaps = 17/316 (5%) Query: 228 LELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRV 287 LE + S D K F EEF SL ++ + + EN+ KNRY NILP DHSRV Sbjct: 15 LEEEIRIRSADDCKQ-FREEFNSLPSGHIQGTFEL--ANKEENREKNRYPNILPNDHSRV 71 Query: 288 ILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVI 347 IL D IP SDYINA+YI G E K +IA+QG + TVNDFW+M W++ S I Sbjct: 72 ILSQLDG-IPCSDYINASYID----GYKEKNK-FIAAQGPKQETVNDFWRMVWEQKSATI 125 Query: 348 VMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPL--DNGDL 405 VM T E+ KC YWP+ G YG V +Y +R + P D Sbjct: 126 VMLTNLKERKEEKCHQYWPDQGCW-TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKA 184 Query: 406 IREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIV 465 R + + SWPD GVP P G+L FL ++ HAGPI+VHCSAG+GRTGT IV Sbjct: 185 PRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPV--HAGPIVVHCSAGVGRTGTFIV 242 Query: 466 IDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEV 525 ID +M + + +D+ + + +R QR MVQT+ QY FIY A+ ++ +L+V Sbjct: 243 IDAMMAMMHAEQ---KVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDV 299 Query: 526 LQSQKGQESEYGNITY 541 +K ++ +G T+ Sbjct: 300 SSLEKHLQTMHGTTTH 315 Score = 154 bits (390), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 110/382 (28%), Positives = 176/382 (46%), Gaps = 38/382 (9%) Query: 160 SPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEE--------------ASGA 205 +P+ I V C G G D++ ++ +K + E Sbjct: 219 NPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQ 278 Query: 206 FVYLRQP---YYA---TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNL 259 + ++ Q YY T ++ + +E + ++ D K G EEF L + Sbjct: 279 YTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFD--KIGLEEEFRKLTNVRIMKE 336 Query: 260 HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAK 319 + R G P N K R I+P+D +RVIL + +DYINA++I Sbjct: 337 NMR-TGNLPANMKKARVIQIIPYDFNRVILSMKRGQ-EYTDYINASFIDGY-----RQKD 389 Query: 320 TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSV 379 +IA+QG L TV DFW+M W+ S IVM T E+ ++KC YWP G +G ++ Sbjct: 390 YFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEG-SVTHGEITI 448 Query: 380 ----TNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQ 435 E + L TL G+ +R + + + WP+ G+P+E G++ + Sbjct: 449 EIKNDTLSEAISIRDFLVTLNQPQARQGEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAA 508 Query: 436 INQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQR 495 + Q+Q+ PI VHCSAG GRTGT I + ++E + +GL +D+ + ++ +R QR Sbjct: 509 V-QKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGL---LDVFQAVKSLRLQR 564 Query: 496 SGMVQTEAQYKFIYVAIAQFIE 517 MVQT QY+F Y + FI+ Sbjct: 565 PHMVQTLEQYEFCYKVVQDFID 586 >2NV5-A nrPDB Length = 299 Score = 198 bits (503), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 113/275 (41%), Positives = 160/275 (58%), Gaps = 20/275 (7%) Query: 244 FWEEFESLQK-QEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302 F +E+ES+ Q+ H LE +P KNRY N++ +DHSRV+L + IPGSDY+ Sbjct: 29 FSQEYESIDPGQQFTWEHSNLEVNKP----KNRYANVIAYDHSRVLLSAIEG-IPGSDYV 83 Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362 NANYI YIA+QG L T DFW+M W++ S +VM T+ E+ R KC Sbjct: 84 NANYIDGY-----RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCD 138 Query: 363 PYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDL-IREIWHYQYLSWPDHG 421 YWP G + +G VT + Y +RT + NG RE+ +Q+ +WPDHG Sbjct: 139 QYWPSRGTE-THGLVQVTLLDTVELATYCVRTFAL--YKNGSSEKREVRQFQFTAWPDHG 195 Query: 422 VPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCD 481 VP P L+FL ++ + + P AGP++VHCSAG+GRTG IVID ++E I + Sbjct: 196 VPEHPTPFLAFLRRV--KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK---T 250 Query: 482 IDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 +DI + ++RAQR+ MVQTE QY FI+ A+ + + Sbjct: 251 VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 285 >1RPM-A nrPDB Length = 278 Score = 196 bits (497), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 112/272 (41%), Positives = 155/272 (56%), Gaps = 17/272 (6%) Query: 243 GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYI 302 GF EE+ES + + ++ EN+ KNRY NI+ +DHSRV LQ + + SDYI Sbjct: 21 GFKEEYESFFEGQSAPWDS---AKKDENRMKNRYGNIIAYDHSRVRLQTIEGD-TNSDYI 76 Query: 303 NANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362 N NYI YIA+QG ++ T+ DFW+M W EN+ I+M T VE GR KC Sbjct: 77 NGNYIDGY-----HRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCC 131 Query: 363 PYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422 YWP+ Y VT EY +RT V + IREI + + WPDHGV Sbjct: 132 KYWPD--DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHE-IREIRQFHFTGWPDHGV 188 Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482 P G+L F+ Q+ + +S P AGP++VHCSAG GRTG IVID++++ +G+ + Sbjct: 189 PYHATGLLGFVRQV--KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---V 243 Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514 DI ++ +R++R MVQTE QY FI+ AI + Sbjct: 244 DIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 275 >6D4D-A nrPDB Length = 292 Score = 194 bits (494), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 122/292 (41%), Positives = 161/292 (55%), Gaps = 21/292 (7%) Query: 228 LELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRV 287 LE + S D K F EEF SL ++ + + EN+ KNRY NILP DHSRV Sbjct: 14 LEEEIRIRSADDCKQ-FREEFNSLPSGHIQGTFEL--ANKEENREKNRYPNILPNDHSRV 70 Query: 288 ILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVI 347 IL D IP SDYINA+YI G E K +IA+QG + TVNDFW+M W++ S I Sbjct: 71 ILSQLDG-IPCSDYINASYID----GYKEKNK-FIAAQGPKQETVNDFWRMVWEQKSATI 124 Query: 348 VMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDT--TEYKLRTLQVSP--LDNG 403 VM T E+ KC YWP+ G YG ++ C E +Y +R + P D Sbjct: 125 VMLTNLKERKEEKCHQYWPDQGCW-TYG--NIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 181 Query: 404 DLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTI 463 R + + SWPD GVP P G+L FL ++ HAGPI+VHCSAG+GRTGT Sbjct: 182 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPV--HAGPIVVHCSAGVGRTGTF 239 Query: 464 IVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515 IVID +M + + +D+ + + +R QR MVQT+ QY FIY A+ ++ Sbjct: 240 IVIDAMMAMMHAEQ---KVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 288 >1LAR-A nrPDB Length = 575 Score = 194 bits (493), Expect = 9e-50, Method: Compositional matrix adjust. Identities = 104/245 (42%), Positives = 147/245 (60%), Gaps = 13/245 (5%) Query: 270 NKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLE 329 NK KNRY N++ +DHSRVIL D +PGSDYINANYI YIA+QG L Sbjct: 43 NKPKNRYANVIAYDHSRVILTSID-GVPGSDYINANYIDGY-----RKQNAYIATQGPLP 96 Query: 330 ATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTE 389 T+ DFW+M W++ + +VM TR EK R KC YWP G + G VT + Sbjct: 97 ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETC-GLIQVTLLDTVELAT 155 Query: 390 YKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPI 449 Y +RT + + + RE+ +Q+++WPDHGVP P +L+FL ++ + + AGP+ Sbjct: 156 YTVRTFALHKSGSSEK-RELRQFQFMAWPDHGVPEYPTPILAFLRRV--KACNPLDAGPM 212 Query: 450 IVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIY 509 +VHCSAG+GRTG IVID ++E + + +DI + +R+QR+ MVQTE QY FI+ Sbjct: 213 VVHCSAGVGRTGCFIVIDAMLERMKHEK---TVDIYGHVTCMRSQRNYMVQTEDQYVFIH 269 Query: 510 VAIAQ 514 A+ + Sbjct: 270 EALLE 274 Score = 186 bits (471), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 117/388 (30%), Positives = 190/388 (48%), Gaps = 34/388 (8%) Query: 149 VLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE-------- 200 +L+ + +PL + V C G G D++ + ++H K I Sbjct: 194 ILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRS 253 Query: 201 ------EASGAFVYLRQPYYA------TRVNAADIENRVLELNKKQESEDTAKAGFWEEF 248 + +V++ + T V A ++ + +L + E EF Sbjct: 254 QRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMEL--EF 311 Query: 249 ESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIK 308 + L + + + + P NK KNR NI+P++ +RV LQ + GSDYINA+++ Sbjct: 312 KLLASSKA-HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQP-IRGVEGSDYINASFLD 369 Query: 309 NQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV 368 K YIA+QG L + DFW+M W+ NS +IVM T+ E GR KC YWP Sbjct: 370 GY-----RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAE 424 Query: 369 GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGG 428 R Y + V E++ +Y LR +V+ +G R I +Q+ WP+ GVP G Sbjct: 425 RSAR-YQYFVVDPMAEYNMPQYILREFKVTDARDGQ-SRTIRQFQFTDWPEQGVPKTGEG 482 Query: 429 VLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTI 488 + F+ Q+++ +E GPI VHCSAG+GRTG I + +++E + +G+ +D+ +T+ Sbjct: 483 FIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV---VDMFQTV 539 Query: 489 QMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 + +R QR MVQTE QY+ Y A +++ Sbjct: 540 KTLRTQRPAMVQTEDQYQLCYRAALEYL 567 >5HDE-A nrPDB Length = 307 Score = 192 bits (487), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 107/266 (40%), Positives = 150/266 (56%), Gaps = 12/266 (4%) Query: 253 KQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLL 312 K + ++ G++ EN KNRYK+ILPFDHSRV L + + SDYINAN+IK + Sbjct: 47 KYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPS-QDSDYINANFIKG-VY 104 Query: 313 GPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQR 372 GP K Y+A+QG L TV DFW+M W+ N +IVM RE E GR KC YWP G Sbjct: 105 GP----KAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDP 160 Query: 373 -AYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLS 431 + P+ ++ E T+Y +RTL L+ + R ++ + Y++WPDH VPS +L Sbjct: 161 ITFAPFKISCEDEQARTDYFIRTLL---LEFQNESRRLYQFHYVNWPDHDVPSSFDSILD 217 Query: 432 FLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMV 491 + + + QE PI +HCSAG GRTG I ID + + + ++ IQ + Sbjct: 218 MISLMRKYQEH--EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEM 275 Query: 492 RAQRSGMVQTEAQYKFIYVAIAQFIE 517 R QR VQT+ QY+ ++ AIAQ E Sbjct: 276 RTQRHSAVQTKEQYELVHRAIAQLFE 301 >2H03-A nrPDB Length = 291 Score = 191 bits (486), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 102/256 (39%), Positives = 141/256 (55%), Gaps = 16/256 (6%) Query: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDEN-AKTYIASQG 326 PEN+GKNRY NILP+D +RV L G GSDYINA+YI P N + YI +QG Sbjct: 51 PENRGKNRYNNILPYDATRVKLSG------GSDYINASYI------PGNNFRREYIVTQG 98 Query: 327 CLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHD 386 L T +DFW+M W++N IVM T+ VEKGR KC YWP YG + E Sbjct: 99 PLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESV 158 Query: 387 TTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA 446 E+ +R ++ + D R I H+ Y WPDHGVP ++ F+ + P A Sbjct: 159 LPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGA 218 Query: 447 GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYK 506 GP +VHCSAG+GRTGT I +D +++ + +K +DI + +R R MVQTE QY Sbjct: 219 GPTVVHCSAGVGRTGTFIALDRILQQLDSKD---SVDIYGAVHDLRLHRVHMVQTECQYV 275 Query: 507 FIYVAIAQFIETTKKK 522 +++ + + K + Sbjct: 276 YLHQCVRDVLRARKLR 291 >2PI7-A nrPDB Length = 312 Score = 191 bits (486), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 112/282 (39%), Positives = 161/282 (57%), Gaps = 21/282 (7%) Query: 250 SLQKQEVKNLH---QRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANY 306 SLQ +E+K + P N+ KNRY NILP+D SRV L + GSDYINANY Sbjct: 35 SLQFEELKLIGLDIPHFAADLPMNRCKNRYTNILPYDFSRVRLVSMNEE-EGSDYINANY 93 Query: 307 IKNQLLGPDENA-KTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW 365 I P N+ + YIA+QG L T NDFW+M Q+ S++IVM T+ EK R KC YW Sbjct: 94 I------PGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 147 Query: 366 PEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSE 425 P AYG +V E + T++ R ++S D ++++ H+ Y +WPDHGVP+ Sbjct: 148 PFTEDPIAYGDITVEMLSEEEHTDWVYRNFRIS---YADEVQDVMHFNYTAWPDHGVPTA 204 Query: 426 PGG--VLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483 +L F+ + RQ+S+ GP+I+HCSAG+GRTGT I +D L+++I +D Sbjct: 205 NAAESILQFVQMV--RQKSVKSKGPMIIHCSAGVGRTGTFIALDWLLQHIRDHEF---VD 259 Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEV 525 I + +R+ R MVQTE QY FI+ + + K++ + Sbjct: 260 ILGLVSDMRSYRMSMVQTEEQYIFIHQCVQLMWQKKKQQFCI 301 >1YFO-A nrPDB Length = 302 Score = 191 bits (485), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 117/300 (39%), Positives = 167/300 (55%), Gaps = 20/300 (6%) Query: 229 ELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVI 288 E+N++ ++ F EEF +L ++ + + ENK KNRY NILP+DHSRV Sbjct: 19 EINRRMADDNKL---FREEFNALPACPIQATCE--AASKEENKEKNRYVNILPYDHSRVH 73 Query: 289 LQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIV 348 L + +P SDYINA++I G E K +IA+QG E TVNDFW+M W++N+ IV Sbjct: 74 LTPVEG-VPDSDYINASFIN----GYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIV 127 Query: 349 MTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTL---QVSPLDNGDL 405 M T E+ KC YWP+ G YG V+ +Y +R QV + N Sbjct: 128 MVTNLKERKECKCAQYWPDQGCW-TYGNVRVSVEDVTVLVDYTVRKFCIQQVGDVTNRKP 186 Query: 406 IREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIV 465 R I + + SWPD GVP P G+L FL ++ +AG I+VHCSAG+GRTGT +V Sbjct: 187 QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVV 244 Query: 466 IDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEV 525 ID +++ + ++ +D+ + +RAQR MVQT+ QY FIY A+ + +LEV Sbjct: 245 IDAMLDMMHSER---KVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEV 301 >2PBN-A nrPDB Length = 313 Score = 191 bits (484), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 116/289 (40%), Positives = 161/289 (55%), Gaps = 30/289 (10%) Query: 243 GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ---GRDSNIPGS 299 GF E+FE +Q+ PENK KNRY NIL +DHSRV L+ G+DS S Sbjct: 30 GFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSK--HS 87 Query: 300 DYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRN 359 DYINANY+ AK YIA+QG L++T DFW+M W++N+ +IVM T VEKGR Sbjct: 88 DYINANYVDGY-----NKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRR 142 Query: 360 KCVPYWPEVGMQRAYGPYSVT-------NCGEHDTTEYKLRTLQVSPLDNGDLI-----R 407 KC YWP + YG VT C + + +R +V G+ R Sbjct: 143 KCDQYWPTENSEE-YGNIIVTLKSTKIHAC--YTVRRFSIRNTKVKKGQKGNPKGRQNER 199 Query: 408 EIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVID 467 + Y Y WPD GVP VL+F+ + + + +P GP++VHCSAG+GRTGT IVID Sbjct: 200 VVIQYHYTQWPDMGVPEYALPVLTFVRRSSAAR--MPETGPVLVHCSAGVGRTGTYIVID 257 Query: 468 MLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 +++ I K +++ ++ +R QR+ +VQTE QY FI+ A+ + I Sbjct: 258 SMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI 303 >2NLK-A nrPDB Length = 627 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 116/289 (40%), Positives = 161/289 (55%), Gaps = 30/289 (10%) Query: 243 GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ---GRDSNIPGS 299 GF E+FE +Q+ PENK KNRY NIL +DHSRV L+ G+DS S Sbjct: 22 GFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSK--HS 79 Query: 300 DYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRN 359 DYINANY+ AK YIA+QG L++T DFW+M W++N+ +IVM T VEKGR Sbjct: 80 DYINANYVDGY-----NKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRR 134 Query: 360 KCVPYWPEVGMQRAYGPYSVT-------NCGEHDTTEYKLRTLQVSPLDNGDLI-----R 407 KC YWP + YG VT C + + +R +V G+ R Sbjct: 135 KCDQYWPTENSEE-YGNIIVTLKSTKIHAC--YTVRRFSIRNTKVKKGQKGNPKGRQNER 191 Query: 408 EIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVID 467 + Y Y WPD GVP VL+F+ + + + +P GP++VHCSAG+GRTGT IVID Sbjct: 192 VVIQYHYTQWPDMGVPEYALPVLTFVRRSSAAR--MPETGPVLVHCSAGVGRTGTYIVID 249 Query: 468 MLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 +++ I K +++ ++ +R QR+ +VQTE QY FI+ A+ + I Sbjct: 250 SMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI 295 Score = 91.7 bits (226), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 68/261 (26%), Positives = 114/261 (43%), Gaps = 20/261 (7%) Query: 263 LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYI 322 Q+ NK KNR +++P + +RV L + G+DYINA+YI + +I Sbjct: 343 FSAQKECNKEKNRNSSVVPSERARVGLAPL-PGMKGTDYINASYIMGYY-----RSNEFI 396 Query: 323 ASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNC 382 +Q L T DFW+M W N+++IVM ++ V YWP ++VT Sbjct: 397 ITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSREESMNCEAFTVTLI 455 Query: 383 GEHDTTEYKLRTLQVSPL----DNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ 438 + + + D + E+ H+Q WP+ P + S + IN Sbjct: 456 SKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP-----ISSTFELINV 510 Query: 439 -RQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSG 497 ++E+L GP IVH G G + + L + + + +D+ + +M+ R G Sbjct: 511 IKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENA---VDVFQVAKMINLMRPG 567 Query: 498 MVQTEAQYKFIYVAIAQFIET 518 + QY+FIY A+ + T Sbjct: 568 VFTDIEQYQFIYKAMLSLVST 588 >5AWX-A nrPDB Length = 298 Score = 189 bits (479), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 117/293 (39%), Positives = 163/293 (55%), Gaps = 21/293 (7%) Query: 233 KQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVIL-QG 291 K ++ A +GF EEFE +Q V P+NK KNRY NI+ +DHSRV L Q Sbjct: 11 KHVADLHASSGFTEEFEEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQL 70 Query: 292 RDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTT 351 + + +DYINANY+ K YIA+QG L++T DFW+M W+ N VIVM T Sbjct: 71 AEKDGKLTDYINANYVDGY-----NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT 125 Query: 352 REVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLR--TLQVSPLDNGDLI--- 406 VEKGR KC YWP G + YG + VT Y +R TL+ + + G Sbjct: 126 NLVEKGRRKCDQYWPADGSEE-YGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRP 184 Query: 407 --REIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA-GPIIVHCSAGIGRTGTI 463 R + Y Y WPD GVP VL+F+ + + HA GP++VHCSAG+GRTGT Sbjct: 185 SGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKR---HAVGPVVVHCSAGVGRTGTY 241 Query: 464 IVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 IV+D +++ I +G ++I ++ +R+QR+ +VQTE QY FI+ + + I Sbjct: 242 IVLDSMLQQIQHEG---TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI 291 >4BJO-A nrPDB Length = 338 Score = 189 bits (479), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 105/290 (36%), Positives = 158/290 (54%), Gaps = 18/290 (6%) Query: 233 KQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGR 292 ++E E K+G W + E + R+ + P+NK +NRY+++ PFDHSR+ L Sbjct: 21 EKEFEQIDKSGSWAAIYQDIRHEASDFPCRV-AKLPKNKNRNRYRDVSPFDHSRIKLHQE 79 Query: 293 DSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTR 352 D+ DYINA+ IK + E ++YI +QG L T FW+M W++ SR +VM R Sbjct: 80 DN-----DYINASLIKME-----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNR 129 Query: 353 EVEKGRNKCVPYWP---EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREI 409 +EKG KC YWP E M +T E + Y +R L++ L + REI Sbjct: 130 VMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQE-TREI 188 Query: 410 WHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 469 H+ Y +WPD GVP P L+FL ++ + P GP++VHCSAGIGR+GT + D Sbjct: 189 LHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTC 248 Query: 470 MENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI---AQFI 516 + + + +DI+K + +R R G++QT Q +F Y+A+ A+FI Sbjct: 249 LLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFI 298 >2I75-A nrPDB Length = 320 Score = 185 bits (470), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 101/250 (40%), Positives = 142/250 (56%), Gaps = 13/250 (5%) Query: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGC 327 P+N KNRY++I P+D +RVIL+G + DYINANYI N + YIA QG Sbjct: 69 PQNISKNRYRDISPYDATRVILKGNE------DYINANYI-NMEIPSSSIINQYIACQGP 121 Query: 328 LEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDT 387 L T DFWQM W++ S ++VM T +VE+GR KC YWPE +YG Y VT E Sbjct: 122 LPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGN 181 Query: 388 TEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAG 447 T Y R + + + + R + QY++WPDHGVP + L F+ + ++ Sbjct: 182 TAYIFRKMTLFNQEKNES-RPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG--KEE 238 Query: 448 PIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKF 507 P++VHCSAGIGRTG +I ++ M I +DI +T+ R QR+ M+QT +QY+F Sbjct: 239 PVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTM---RDQRAMMIQTPSQYRF 295 Query: 508 IYVAIAQFIE 517 + AI + E Sbjct: 296 VCEAILKVYE 305 >1WCH-A nrPDB Length = 315 Score = 185 bits (470), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 112/269 (41%), Positives = 150/269 (55%), Gaps = 21/269 (7%) Query: 246 EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINAN 305 +E E+LQ E+K L Q L GQ EN+ KNRYKNILP+D +RV L YINA+ Sbjct: 53 KELENLQ--ELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGG------YINAS 104 Query: 306 YIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW 365 +IK + G +E YIA QG L TV DFWQM W++ S VI M T+EVE + KC YW Sbjct: 105 FIKIPV-GKEEFV--YIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYW 161 Query: 366 PEV--GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423 P + + + +R + + + + +R I H + +WPDH P Sbjct: 162 PNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE-VRHISHLNFTAWPDHDTP 220 Query: 424 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483 S+P +L+F+ + S GPII HCSAGIGR+GT+I ID+++ IS D D D Sbjct: 221 SQPDDLLTFISYMRHIHRS----GPIITHCSAGIGRSGTLICIDVVLGLISQ---DLDFD 273 Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAI 512 I ++ +R QR GMVQTE QY F Y I Sbjct: 274 ISDLVRCMRLQRHGMVQTEDQYIFCYQVI 302 >2GJT-A nrPDB Length = 295 Score = 184 bits (468), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 110/279 (39%), Positives = 159/279 (56%), Gaps = 22/279 (7%) Query: 250 SLQKQEVKNLH---QRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANY 306 SLQ +E+K + P N+ KNRY NILP+D SRV L + G+DYINANY Sbjct: 26 SLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEE-EGADYINANY 84 Query: 307 IKNQLLGPDENA-KTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW 365 I P N+ + YIA+QG L T NDFW+M Q+ S++IVM T+ EK R KC YW Sbjct: 85 I------PGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 138 Query: 366 PEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSE 425 P AYG +V E + ++ R ++ + D ++++ H+ Y +WPDHGVP+ Sbjct: 139 PFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHFNYTAWPDHGVPTA 195 Query: 426 PGG--VLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483 +L F+ + RQ++ GP+I+HCSAG+GRTGT I +D L+++I +D Sbjct: 196 NAAESILQFVHMV--RQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEF---VD 250 Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKK 522 I + +R+ R MVQTE QY FI+ + Q + KK+ Sbjct: 251 ILGLVSEMRSYRMSMVQTEEQYIFIHQCV-QLMWMKKKQ 288 >3OLR-A nrPDB Length = 313 Score = 182 bits (462), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 108/288 (37%), Positives = 157/288 (54%), Gaps = 16/288 (5%) Query: 235 ESEDTAKAGFWEEFESLQKQEVK----NLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ 290 +S+ K F EF L++Q K + ++P+N KNRYK+ILP+D+SRV L Sbjct: 34 QSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELS 93 Query: 291 GRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMT 350 S+ S YINAN+IK + GP K YIA+QG L T+ DFW+M W+ + +IVM Sbjct: 94 LITSD-EDSSYINANFIKG-VYGP----KAYIATQGPLSTTLLDFWRMIWEYSVLIIVMA 147 Query: 351 TREVEKGRNKCVPYWPEVG-MQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREI 409 E E G+ KC YW E G MQ +GP+SV+ E ++Y +RTL+V R I Sbjct: 148 CMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK---FNSETRTI 204 Query: 410 WHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 469 + + Y +WPDH VPS +L + + QE + PI +H SAG GRTG I ID Sbjct: 205 YQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHSSAGCGRTGVICAIDYT 262 Query: 470 MENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE 517 + + + + I+ +R QR +VQT+ QY+ +Y A+ + + Sbjct: 263 WMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK 310 >3I36-A nrPDB Length = 342 Score = 181 bits (459), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 109/309 (35%), Positives = 164/309 (53%), Gaps = 17/309 (5%) Query: 232 KKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQG 291 KKQ+++ + GF EE+E L+ + + + EN+GKNRY N+LP+D SRV L Sbjct: 36 KKQQAD--SNCGFAEEYEDLKLIGIS--LPKYAAEIAENRGKNRYNNVLPYDISRVKLSV 91 Query: 292 RDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTT 351 + + DYINANY+ + K +IA+QG L T+ DFW+M W++N IVM T Sbjct: 92 QTHS--TDDYINANYMPGY-----HSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIVMLT 144 Query: 352 REVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWH 411 + VE+GR KC YWP Q YG +V E E+ +R V + + + + Sbjct: 145 KCVEQGRTKCEEYWPSKQAQ-DYGDITVAMTSEVVLPEWTIRDFVVKNMQSSES-HPLRQ 202 Query: 412 YQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLME 471 + + SWPDHGVP +++F + + +P PI+VHCSAG+GRTGT I ID L+ Sbjct: 203 FHFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPESPILVHCSAGVGRTGTFIAIDRLIY 262 Query: 472 NISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK-KKLEVLQSQK 530 I + +D+ + +R R MVQTE QY F+ + I K K++++ Sbjct: 263 QIENENT---VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRAQKDSKVDLIYQNT 319 Query: 531 GQESEYGNI 539 + Y N+ Sbjct: 320 TAMTIYENL 328 >1YGU-A nrPDB Length = 610 Score = 181 bits (458), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 109/299 (36%), Positives = 165/299 (55%), Gaps = 15/299 (5%) Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYK 277 +N I +L K++ D + F EF+S+ + V + E ++P N+ KNRY Sbjct: 5 MNVEPIHADILLETYKRKIADEGRP-FLAEFQSIPR--VFSKFPIKEARKPFNQNKNRYV 61 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 +ILP+D++RV L + + GS+YINA+YI + + YIA+QG + TV+DFW+ Sbjct: 62 DILPYDYNRVELSEINGD-AGSNYINASYIDG-----FKEPRKYIAAQGPRDETVDDFWR 115 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM-QRAYGPYSVTNCGEHDTTEYKLRTLQ 396 M W++ + VIVM TR E RNKC YWP + RA+G V +Y ++ L Sbjct: 116 MIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLN 175 Query: 397 VSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAG 456 + RE+ H Q+ SWPDHGVP +P +L ++N +GPI+VH SAG Sbjct: 176 IVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFF--SGPIVVHSSAG 233 Query: 457 IGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515 +GRTGT I ID ++E + + +D+ + +R QR MVQ EAQY I+ A+ ++ Sbjct: 234 VGRTGTYIGIDAMLEGLEAEN---KVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 289 Score = 121 bits (304), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 84/278 (30%), Positives = 133/278 (47%), Gaps = 43/278 (15%) Query: 265 GQRPENKGKNRYKNILPFDHSRVILQ------------------GRDSNIPGSDYINANY 306 G + ENK KNR N++P+D++RV L+ + S YINA++ Sbjct: 340 GNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASF 399 Query: 307 IKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWP 366 I + + IA+QG L+ T+ DFWQM +Q +VIVM T + C YW Sbjct: 400 IMSYW-----KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG 454 Query: 367 EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEP 426 E G Q YG V ++ Y LR ++ D R ++ YQY +W +P+EP Sbjct: 455 E-GKQ-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS-RTVYQYQYTNWSVEQLPAEP 511 Query: 427 GGVLSFLDQINQRQESLPH-----------AGPIIVHCSAGIGRTGTIIVIDMLMENIST 475 ++S + + Q+ LP + P+++HC G +TG + L+E+ T Sbjct: 512 KELISMIQVVKQK---LPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAET 568 Query: 476 KGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIA 513 + + +DI + ++ +R R GMV T QY+F+Y IA Sbjct: 569 EEV---VDIFQVVKALRKARLGMVSTFEQYQFLYDVIA 603 >3S3F-A nrPDB Length = 307 Score = 181 bits (458), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 108/279 (38%), Positives = 151/279 (54%), Gaps = 26/279 (9%) Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303 F EEFE L+ V P N+ KNR+ NILP+DHSR LQ D + GSDYIN Sbjct: 46 FSEEFEELK--HVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDD-EGSDYIN 102 Query: 304 ANYIKNQLLGPDENA-KTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV 362 ANY+ P N+ + +I +QG L +T +DFW+M W+ NSR IVM TR EKGR KC Sbjct: 103 ANYV------PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCD 156 Query: 363 PYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422 YWP + YG V + ++ + L G R + H+ + +WPD GV Sbjct: 157 QYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFM---LCRGSEQRILRHFHFTTWPDFGV 213 Query: 423 PSEPGGVLSFL----DQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGL 478 P+ P ++ F+ D+I Q PI+VHCSAG+GR+GT I +D +++ I+T Sbjct: 214 PNPPQTLVRFVRAFRDRIGAEQR------PIVVHCSAGVGRSGTFITLDRILQQINTSDY 267 Query: 479 DCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE 517 +DI + +R +R MVQTE QY I+ + +E Sbjct: 268 ---VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE 303 >4GE6-A nrPDB Length = 314 Score = 180 bits (457), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 112/312 (35%), Positives = 168/312 (53%), Gaps = 32/312 (10%) Query: 219 NAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQE-VKNLHQRLEGQRPENKGKNRYK 277 +A I+ V +N +Q K G +EE+E ++++ V H + P N KNRY Sbjct: 9 HAMTIQELVDYVNARQ------KQGIYEEYEDIRRENPVGTFHCSMS---PGNLEKNRYG 59 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 ++ D +RV L R + +DYINA+++ + YI +QG LE T DFW Sbjct: 60 DVPCLDQTRVKLTKRSGHTQ-TDYINASFMDGY-----KQKNAYIGTQGPLENTYRDFWL 113 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWP-EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQ 396 M W++ VIVMTTR E GR KC YWP E + +G +VTN G + YK TL+ Sbjct: 114 MVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLE 173 Query: 397 VSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-NQRQESLPHAG-------- 447 + + R++ H+Q+LSWPD+GVPS ++ FL + NQ+ ++ + G Sbjct: 174 IHNTEERQK-RQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCP 232 Query: 448 --PIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQY 505 PI+VHCSAGIGRTGT +D+ + + G +++ +T+ +R QR+ +QT QY Sbjct: 233 EPPIVVHCSAGIGRTGTFCSLDICLAQLEELG---TLNVFQTVSRMRTQRAFSIQTPEQY 289 Query: 506 KFIYVAIAQFIE 517 F Y AI +F E Sbjct: 290 YFCYKAILEFAE 301 >4GFV-A nrPDB Length = 297 Score = 179 bits (454), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 107/303 (35%), Positives = 161/303 (53%), Gaps = 14/303 (4%) Query: 220 AADIENRVLE-LNKKQESEDTAKAGFWEEFESLQKQ-EVKNLHQRLEGQRPENKGKNRYK 277 AAD LE L + E AG + + ++ + + + G RPEN KNRYK Sbjct: 1 AADSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYK 60 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 ++LP+D +RVIL SDYIN N+I+ + + YIA+QG L T+ DFW+ Sbjct: 61 DVLPYDQTRVILSLLQEE-GHSDYINGNFIRGV-----DGSLAYIATQGPLPHTLLDFWR 114 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTE-YKLRTLQ 396 + W+ +VI+M RE+E GR +C YW + G + +T E E LRTL+ Sbjct: 115 LVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLK 174 Query: 397 VSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAG 456 V+ R ++ QY+SWPD GVPS P +L+ +++ + Q S P P+ VH SAG Sbjct: 175 VTFQKES---RSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPE--PLCVHSSAG 229 Query: 457 IGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 GRTG + +D + + + T+ + D + + +R QR VQTE QY+F+Y +AQ Sbjct: 230 CGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF 289 Query: 517 ETT 519 +T Sbjct: 290 CST 292 >2BZL-A nrPDB Length = 325 Score = 179 bits (453), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 111/332 (33%), Positives = 181/332 (54%), Gaps = 29/332 (8%) Query: 202 ASGAFVYLRQPYYATRVNAADI--ENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNL 259 +SG + Y+ + V+A + + R L KK E + + E+E + K++ + Sbjct: 8 SSGVDLGTENLYFQSMVDATRVPMDERFRTLKKKLE-----EGMVFTEYEQIPKKKANGI 62 Query: 260 HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAK 319 PEN ++R + ++P++ +RV L N G YINA++IK + G + + Sbjct: 63 FS--TAALPENAERSRIREVVPYEENRVELIPTKENNTG--YINASHIKVVVGGAEWH-- 116 Query: 320 TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA---YGP 376 YIA+QG L T +DFWQM W++ VI M T E E GR K YWP++G + + YG Sbjct: 117 -YIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGK 175 Query: 377 YSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI 436 + VT D+ Y L+V L +G R +WH QY WPDHG P + G LS+L++I Sbjct: 176 FKVTTKFRTDSVCYATTGLKVKHLLSGQE-RTVWHLQYTDWPDHGCPEDVQGFLSYLEEI 234 Query: 437 N--QRQESLPHAG------PIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTI 488 +R + G PI+VHCSAG+GRTG +I+ ++++ + + +++ + Sbjct: 235 QSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEH---NEKVEVPMML 291 Query: 489 QMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK 520 +++R QR M+QT AQYKF+Y + QF++ ++ Sbjct: 292 RLLREQRMFMIQTIAQYKFVYQVLIQFLQNSR 323 >1ZC0-A nrPDB Length = 309 Score = 179 bits (453), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 96/248 (38%), Positives = 140/248 (56%), Gaps = 14/248 (5%) Query: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGC 327 P + K+RYK ILP SRV L GR + DYINANYI+ G D K YIA+QG Sbjct: 66 PGHASKDRYKTILPNPQSRVCL-GRAQSQEDGDYINANYIR----GYDGKEKVYIATQGP 120 Query: 328 LEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDT 387 + TV+DFW+M WQE +IVM T ++ +G+ KCV YWP + YGP+ + + Sbjct: 121 MPNTVSDFWEMVWQEEVSLIVMLT-QLREGKEKCVHYWPT--EEETYGPFQIRIQDMKEC 177 Query: 388 TEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAG 447 EY +R L + + R + H + +WPDH P G +L + ++ + E+ H G Sbjct: 178 PEYTVRQLTIQYQEER---RSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPG 234 Query: 448 PIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKF 507 PI+VHCSAGIGRTG I + + + +G ++DI + +R R GM+QT QY+F Sbjct: 235 PIVVHCSAGIGRTGCFIATRIGCQQLKARG---EVDILGIVCQLRLDRGGMIQTAEQYQF 291 Query: 508 IYVAIAQF 515 ++ +A + Sbjct: 292 LHHTLALY 299 >5OVR-A nrPDB Length = 305 Score = 178 bits (452), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 101/244 (41%), Positives = 139/244 (56%), Gaps = 14/244 (5%) Query: 273 KNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATV 332 KNRYK ILP HSRV L D + P S YINANYI+ G K YIA+QG + +TV Sbjct: 67 KNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIR----GYGGEEKVYIATQGPIVSTV 122 Query: 333 NDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKL 392 DFW+M WQE++ +IVM T +E+ KC YWPE Q AY +T T +Y+L Sbjct: 123 ADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPE--EQVAYDGVEITVQKVIHTEDYRL 179 Query: 393 RTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ-RQESLPHAGPIIV 451 R + L +G R + HY + SWPD P +L + ++ + Q+ PH PIIV Sbjct: 180 RLIS---LKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIV 236 Query: 452 HCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVA 511 HCSAGIGRTG I + + + +G+ +DI KT +R R GM+QT QY+F++ Sbjct: 237 HCSAGIGRTGCFIATSICCQQLRQEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHHV 293 Query: 512 IAQF 515 ++ + Sbjct: 294 MSLY 297 >6H8S-A nrPDB Length = 301 Score = 175 bits (443), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 100/244 (40%), Positives = 136/244 (55%), Gaps = 14/244 (5%) Query: 273 KNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATV 332 KNRYK ILP HSRV L D P S YINANYI+ G K YIA+QG + +TV Sbjct: 63 KNRYKTILPNPHSRVRLTSPDPEDPLSSYINANYIR----GYSGEEKVYIATQGPIVSTV 118 Query: 333 NDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKL 392 DFW+M WQE + +IVM T +E+ KC YWPE Q + +T T +Y+L Sbjct: 119 ADFWRMVWQERTPIIVMIT-NIEEMNEKCTEYWPE--EQVVHDGVEITVQKVIHTEDYRL 175 Query: 393 RTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ-RQESLPHAGPIIV 451 R + L G R + HY + SWPD P +L + ++ + Q+ PH PIIV Sbjct: 176 RLIS---LRRGTEERTLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCSPIIV 232 Query: 452 HCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVA 511 HCSAGIGRTG I + + + +G+ +DI KT +R R GM+QT QY+F++ A Sbjct: 233 HCSAGIGRTGCFIATSICCQQLRREGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHHA 289 Query: 512 IAQF 515 ++ + Sbjct: 290 MSLY 293 >1L8K-A nrPDB Length = 314 Score = 175 bits (443), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 96/252 (38%), Positives = 146/252 (57%), Gaps = 22/252 (8%) Query: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGC 327 PEN+ +NRY+++ P+DHSRV LQ ++ DYINA+ L+ +E ++YI +QG Sbjct: 40 PENRNRNRYRDVSPYDHSRVKLQNAEN-----DYINAS-----LVDIEEAQRSYILTQGP 89 Query: 328 LEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGP--YSVTNCGEH 385 L T FW M WQ+ ++ +VM R VEK KC YWP + + +SV E Sbjct: 90 LPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSED 149 Query: 386 DTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPH 445 + Y + LQ+ +++G+ R I H+ Y +WPD GVP P L+FL ++ + P Sbjct: 150 VKSYYTVHLLQLENINSGE-TRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPD 208 Query: 446 AGPIIVHCSAGIGRTGTIIVID---MLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTE 502 GP ++HCSAGIGR+GT ++D +LME KG DI+I++ + +R R G++QT Sbjct: 209 HGPAVIHCSAGIGRSGTFSLVDTCLVLME----KG--DDINIKQVLLNMRKYRMGLIQTP 262 Query: 503 AQYKFIYVAIAQ 514 Q +F Y+AI + Sbjct: 263 DQLRFSYMAIIE 274 >2CFV-A nrPDB Length = 316 Score = 175 bits (443), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 103/289 (35%), Positives = 153/289 (52%), Gaps = 16/289 (5%) Query: 232 KKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQG 291 KKQ+++ + GF EE+E L+ + + + EN+GKNRY N+LP+D SRV L Sbjct: 36 KKQQAD--SNCGFAEEYEDLKLVGIS--QPKYAAELAENRGKNRYNNVLPYDISRVKLSV 91 Query: 292 RDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTT 351 + + DYINANY+ + K +IA+QG L T+ DFW+M W++N I+M T Sbjct: 92 QTHS--TDDYINANYMPGY-----HSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT 144 Query: 352 REVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWH 411 + VE+GR KC YWP Q YG +V E E+ +R V + + + Sbjct: 145 KCVEQGRTKCEEYWPSKQAQD-YGDITVAMTSEIVLPEWTIRDFTVKNIQTSES-HPLRQ 202 Query: 412 YQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLME 471 + + S PDHGVP +++F + + P PI+VHCSAG+GRTGT I ID L+ Sbjct: 203 FHFTSAPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIY 262 Query: 472 NISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK 520 I + +D+ + +R R MVQTE QY F+ + + + K Sbjct: 263 QIENENT---VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK 308 >2QEP-A nrPDB Length = 304 Score = 175 bits (443), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 106/271 (39%), Positives = 150/271 (55%), Gaps = 16/271 (5%) Query: 245 WEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINA 304 WE + Q + + QR EN KNR +L +DHSRV+L+ +S+ SDYINA Sbjct: 36 WEALCAYQAEP----NSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSH-SHSDYINA 90 Query: 305 NYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPY 364 + I + D YIA+QG L ATV DFWQM W+ VIVM T E G +C Y Sbjct: 91 SPIMDH----DPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHY 146 Query: 365 WPEVGMQRAYGPYSVTNCGEHDTTE-YKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423 WP+ G Y Y V EH E + +R+ + L + R + + +LSW D GVP Sbjct: 147 WPDEG-SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNE-TRTVTQFHFLSWYDRGVP 204 Query: 424 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483 S +L F ++N+ + PIIVHCS G GR+GT ++IDM++ ++ KG +ID Sbjct: 205 SSSRSLLDFRRKVNKCYRG--RSCPIIVHCSDGAGRSGTYVLIDMVLNKMA-KGAK-EID 260 Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514 I T++ +R QR GMVQT+ Q++F A+A+ Sbjct: 261 IAATLEHLRDQRPGMVQTKEQFEFALTAVAE 291 >2A8B-A nrPDB Length = 283 Score = 169 bits (428), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 97/248 (39%), Positives = 135/248 (54%), Gaps = 13/248 (5%) Query: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGC 327 P + KNRYK ILP SRV L+ ++ S YINANYI+ G K +IA+QG Sbjct: 41 PRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIR----GYSGKEKAFIATQGP 96 Query: 328 LEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDT 387 + TV+DFWQM WQE+S VIVM T+ EK KCV YWPE + YG V ++ Sbjct: 97 MINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPE--KRGIYGKVEVLVISVNEC 153 Query: 388 TEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAG 447 Y +R L L G + + HY Y SWPDH P +L + + + + + G Sbjct: 154 DNYTIRNLV---LKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRG 210 Query: 448 PIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKF 507 P++VHCSAGIGRTG I + + + +G+ +D + +R R GMVQT QY+F Sbjct: 211 PVVVHCSAGIGRTGCFIATSIGCQQLKEEGV---VDALSIVCQLRMDRGGMVQTSEQYEF 267 Query: 508 IYVAIAQF 515 ++ A+ + Sbjct: 268 VHHALCLY 275 >4IKC-A nrPDB Length = 281 Score = 164 bits (416), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 97/274 (35%), Positives = 152/274 (55%), Gaps = 17/274 (6%) Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303 F EEF L K +++L + P N+ KNR+ NI P++++RV L D+++PGSDYIN Sbjct: 24 FQEEFSELPK-FLQDL-SSTDADLPWNRAKNRFPNIKPYNNNRVKLIA-DASVPGSDYIN 80 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 A+YI L P+E +IA+QG L TV DFW+M W+ ++ +VM T+ EKGR +C Sbjct: 81 ASYISGYLC-PNE----FIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQ 135 Query: 364 YWPEVGMQ-RAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422 YWPE +G +T E ++ +R L++ + +R+ + +WP+HGV Sbjct: 136 YWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQC---NFTAWPEHGV 192 Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482 P ++ F+ + R P+IVH SAG+GRTG I +D L ++I+ + Sbjct: 193 PENSAPLIHFVKLV--RASRAHDTTPMIVHSSAGVGRTGVFIALDHLTQHINDHDF---V 247 Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 DI + +R++R MVQ AQY F++ I + Sbjct: 248 DIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 281 >2I1Y-A nrPDB Length = 301 Score = 163 bits (412), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 97/255 (38%), Positives = 144/255 (56%), Gaps = 12/255 (4%) Query: 270 NKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLE 329 N KNR+ + LP+DH+R+ L+ +S+ SDYINA+ I D YIA+QG L Sbjct: 56 NIKKNRHPDFLPYDHARIKLKV-ESSPSRSDYINASPIIEH----DPRMPAYIATQGPLS 110 Query: 330 ATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTE 389 T+ DFWQM W+ VIVM T VE G +C YWP+ G Y Y V EH E Sbjct: 111 HTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGAS-LYHVYEVNLVSEHIWCE 169 Query: 390 -YKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGP 448 + +R+ + + + R + + +LSWP G P+ +L F ++N+ + P Sbjct: 170 DFLVRSFYLKNVQTQE-TRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG--RSCP 226 Query: 449 IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFI 508 IIVHCS G GRTGT I+IDM++ ++ KG+ +IDI T++ VR QR G+V+++ Q++F Sbjct: 227 IIVHCSDGAGRTGTYILIDMVLNRMA-KGVK-EIDIAATLEHVRDQRPGLVRSKDQFEFA 284 Query: 509 YVAIAQFIETTKKKL 523 A+A+ + K L Sbjct: 285 LTAVAEEVNAILKAL 299 >4RHG-A nrPDB Length = 306 Score = 162 bits (411), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 93/258 (36%), Positives = 141/258 (54%), Gaps = 24/258 (9%) Query: 265 GQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDEN-AKTYIA 323 + P+N KNRYK++LP+D +RV+LQG + DYINA+Y+ ++ P N YIA Sbjct: 62 AKLPQNLDKNRYKDVLPYDTTRVLLQGNE------DYINASYVNMEI--PAANLVNKYIA 113 Query: 324 SQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCG 383 +QG L T FWQ+ W + +IVM T E+GR KC YWP+ +G + + Sbjct: 114 TQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS 173 Query: 384 EHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESL 443 E T Y R + V+ G+ + H QY++WP+HGVP + L F++ + + Sbjct: 174 EDCTIAYVSREMLVTNTQTGEE-HTVTHLQYVAWPEHGVPDDSSDFLEFVNYVRSLRVD- 231 Query: 444 PHAGPIIVHCSAGIGRTGTIIVIDMLM----ENISTKGLDCDIDIQKTIQMVRAQRSGMV 499 + P++VH SAGIGRTG ++ ++ M N+ LD ++ +R QR+ MV Sbjct: 232 --SEPVLVHSSAGIGRTGVLVTMETAMCLTERNLPIYPLD-------IVRKMRDQRAMMV 282 Query: 500 QTEAQYKFIYVAIAQFIE 517 QT +QYKF+ AI + E Sbjct: 283 QTSSQYKFVCEAILRVYE 300 >1P15-A nrPDB Length = 253 Score = 159 bits (403), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 91/255 (35%), Positives = 143/255 (56%), Gaps = 14/255 (5%) Query: 265 GQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIAS 324 G P N KNR I+P++ +RVI+ + +DY+NA++I +YIAS Sbjct: 4 GNLPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFIDGY-----RQKDSYIAS 57 Query: 325 QGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGE 384 QG L T+ DFW+M W+ S IVM T E+G+ KC YWP G+ +YG +V E Sbjct: 58 QGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLV-SYGDITVELKKE 116 Query: 385 HDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI-NQRQESL 443 + Y +R L V+ R+I + + WP+ G+PS+ G+++ + + Q+Q+S Sbjct: 117 EECESYTVRDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMINIIAAVQKQQQQSG 175 Query: 444 PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEA 503 H PI VHCSAG GRTGT + ++E + +G+ +D+ +T++ +R QR MVQT Sbjct: 176 NH--PITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLE 230 Query: 504 QYKFIYVAIAQFIET 518 QY+F Y + ++I+ Sbjct: 231 QYEFCYKVVQEYIDA 245 >6D3F-A nrPDB Length = 279 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 93/280 (33%), Positives = 141/280 (50%), Gaps = 16/280 (5%) Query: 242 AGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDY 301 G EEF L + + R G P N K R I+P+D +RVIL + +DY Sbjct: 3 GGLEEEFRKLTNVRIMKENMR-TGNLPANMKKARVIQIIPYDFNRVILSMKRGQ-EYTDY 60 Query: 302 INANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKC 361 INA++I +IA+QG L TV DFW+M W+ S IVM T E+ ++KC Sbjct: 61 INASFIDGY-----RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKC 115 Query: 362 VPYWPEVGMQRAYGPYSV----TNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSW 417 YWP G +G ++ E + L TL + +R + + + W Sbjct: 116 YQYWPTEG-SVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGW 174 Query: 418 PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477 P+ G+P+E G++ + + Q+Q+ PI VHCSAG GRTGT I + ++E + +G Sbjct: 175 PEIGIPAEGKGMIDLIAAV-QKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEG 233 Query: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE 517 L +D+ + ++ +R QR MVQT QY+F Y + FI+ Sbjct: 234 L---LDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 270 >4AZ1-A nrPDB Length = 302 Score = 104 bits (260), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 77/260 (29%), Positives = 118/260 (45%), Gaps = 35/260 (13%) Query: 269 ENKGKNRYKNILPFDHSRVILQGRDSNIPGSD---YINANYIKNQLLGPDENAKTYIASQ 325 +N+ KNRY +IL + L + ++ PG+ YIN N I L ++A Q Sbjct: 44 KNRHKNRYLDILA---NEATLYPQVTDAPGASTPYYINGNLIDLDL------PHKFVACQ 94 Query: 326 GCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVT-NCG- 383 + + DF M +++ +++M T+ E G K YWPE +R G +V+ NCG Sbjct: 95 APVVQGIPDFLAMLYEKKISLVIMVTKLEEGGFVKADRYWPE---ERGSGSIAVSGNCGL 151 Query: 384 -----------EHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSF 432 D + R L + D + QY WPDHG+P + + Sbjct: 152 TISEDPGKAYEVEDELKITRRYLILQRADEPP--HKFTQVQYTGWPDHGIPQSATSLEAL 209 Query: 433 LDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVR 492 L + P P++VHCSAGIGRTGT+I + ++ +G D + + +R Sbjct: 210 LTNVKNS----PTTVPVVVHCSAGIGRTGTLIGAYAALTHLE-RGTLTDTTVYDVVSAMR 264 Query: 493 AQRSGMVQTEAQYKFIYVAI 512 QR GMVQ QY IY+ + Sbjct: 265 RQRFGMVQRMEQYFVIYLTL 284 >3M4U-A nrPDB Length = 306 Score = 95.1 bits (235), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 82/278 (29%), Positives = 124/278 (44%), Gaps = 26/278 (9%) Query: 247 EFESLQKQE-VKNLHQRLEGQRPENKGKNRYKNILPFDHSRV--ILQGRDSNIPGSDYIN 303 EF LQ+QE +N++ + N+ KNRY +IL + + +L+ + YIN Sbjct: 24 EFVQLQRQENPRNINFTTSLK---NRHKNRYLDILANEETIYPPVLKAVGAQPGRYPYIN 80 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 N I L T++A Q + V DF + ++ ++VM T+ E G K Sbjct: 81 GNLIDLDL------PHTFVACQAPVPQGVPDFLETLSEKKVDLVVMLTKLREGGVLKAER 134 Query: 364 YWPEVGMQRAYGPYS------VTNCGEHDTTEYKLRTLQVSPLD---NGDLIREIWHYQY 414 YWPE P S VT E + PL G + + QY Sbjct: 135 YWPEEEEDSLSFPESGHDAIKVTRDAEASYEVDAELDIVRRPLVIHVPGKPMHRVLQVQY 194 Query: 415 LSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENIS 474 + WPDHGVP D++ ++ PI+VHCSAGIGRTGT+I + +I Sbjct: 195 VGWPDHGVPESAAS----FDELLSVIKNCVTTSPILVHCSAGIGRTGTLIGAYAALLHIE 250 Query: 475 TKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI 512 +G+ D + + ++ +R GMVQ QY IY+ + Sbjct: 251 -RGILTDSTVYSIVAAMKQKRFGMVQRLEQYAVIYMTV 287 >1AD5-A nrPDB Length = 438 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 41/110 (37%), Positives = 54/110 (49%), Gaps = 15/110 (13%) Query: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSV-----RVGDQVTH--IRIQ 55 WF + +S DAE L G + GSF+ R S +G +SLSV R GD V H IR Sbjct: 66 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 125 Query: 56 NSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDP 105 ++G FY + F+TL ELV++Y + DG L P S P Sbjct: 126 DNGGFY-ISPRSTFSTLQELVDHYK------KGNDGLCQKLSVPCMSSKP 168 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 45/172 (26%), Positives = 74/172 (43%), Gaps = 10/172 (5%) Query: 66 GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQ 125 G++ L E E++ + L R I Y +E W+ +S AE L Sbjct: 24 GDQMVVLEESGEWWKARS--LATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLL 81 Query: 126 AKGEPW-TFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV-MCEGGRYTVGGLET 183 A G +F++R+S + G + LSV P+ G V H K+ + G + + T Sbjct: 82 APGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGD----TVKHYKIRTLDNGGFYISPRST 137 Query: 184 FDSLTDLVEHFKK--TGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKK 233 F +L +LV+H+KK G+ + +P +A +I L+L KK Sbjct: 138 FSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKK 189 >1GRI-A nrPDB Length = 217 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 40/123 (32%), Positives = 61/123 (49%), Gaps = 16/123 (13%) Query: 86 LQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDF 145 L +DG I P N + W+ G + +AE +L + FL+RES S PGDF Sbjct: 41 LNGKDGFI-----PKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDF 95 Query: 146 VLSVLSDQPKAGPGSPLRVTHIKVMCEG-GRYTVGGLETFDSLTDLVEHFKKTGIEEASG 204 LSV K G V H KV+ +G G+Y + ++ F+SL +LV++ + T + Sbjct: 96 SLSV-----KFGND----VQHFKVLRDGAGKYFLWVVK-FNSLNELVDYHRSTSVSRNQQ 145 Query: 205 AFV 207 F+ Sbjct: 146 IFL 148 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 28/76 (36%), Positives = 39/76 (51%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 WF + AE +L + G+FL R S GDFSLSV+ G+ V H ++ G Sbjct: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119 Query: 64 YGGEKFATLTELVEYY 79 KF +L ELV+Y+ Sbjct: 120 LWVVKFNSLNELVDYH 135 >2CRH-A nrPDB Length = 138 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 29/85 (34%), Positives = 47/85 (55%), Gaps = 3/85 (3%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+ + AE++L R G+FL R K+ +F++S++ +V HI+I + Y + Sbjct: 28 WYAGPMERAGAESILANRS-DGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRI 86 Query: 64 YGGEKFATLTELVEYYTQQQGVLQD 88 + F LTELVE+Y QQ L+D Sbjct: 87 TEKKAFRGLTELVEFY--QQNSLKD 109 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 10/93 (10%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 WY G M AE++L + + TFLVR+ + +F +S+ + + V HIK+ Sbjct: 28 WYAGPMERAGAESILANRSDG-TFLVRQRVKDAAEFAISIKYN---------VEVKHIKI 77 Query: 170 MCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEA 202 M G Y + + F LT+LVE +++ +++ Sbjct: 78 MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDC 110 >2FO0-A nrPDB Length = 495 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 104 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 162 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 163 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 193 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 13/96 (13%) Query: 99 PLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGP 158 P+N + S WYHG +S AE LL + G +FLVRES S PG +S+ + Sbjct: 95 PVNSLEKHS--WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG----- 146 Query: 159 GSPLRVTHIKV-MCEGGRYTVGGLETFDSLTDLVEH 193 RV H ++ G+ V F++L +LV H Sbjct: 147 ----RVYHYRINTASDGKLYVSSESRFNTLAELVHH 178 >3T04-A nrPDB Length = 123 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 18 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 76 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 77 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 107 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 30/85 (35%), Positives = 42/85 (49%), Gaps = 11/85 (12%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 WYHG +S AE LL + G +FLVRES S PG +S+ + RV H ++ Sbjct: 18 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG---------RVYHYRI 67 Query: 170 -MCEGGRYTVGGLETFDSLTDLVEH 193 G+ V F++L +LV H Sbjct: 68 NTASDGKLYVSSESRFNTLAELVHH 92 >4XEY-B nrPDB Length = 408 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 12 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 70 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 71 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 101 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/85 (35%), Positives = 42/85 (49%), Gaps = 11/85 (12%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 WYHG +S AE LL + G +FLVRES S PG +S+ + RV H ++ Sbjct: 12 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG---------RVYHYRI 61 Query: 170 -MCEGGRYTVGGLETFDSLTDLVEH 193 G+ V F++L +LV H Sbjct: 62 NTASDGKLYVSSESRFNTLAELVHH 86 >2LCT-A nrPDB Length = 107 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 29/85 (34%), Positives = 47/85 (55%), Gaps = 3/85 (3%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+ + AE++L R G+FL R K+ +F++S++ +V HI+I + Y + Sbjct: 11 WYAGPMERAGAESILANRS-DGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRI 69 Query: 64 YGGEKFATLTELVEYYTQQQGVLQD 88 + F LTELVE+Y QQ L+D Sbjct: 70 TEKKAFRGLTELVEFY--QQNSLKD 92 Score = 48.9 bits (115), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 50/99 (50%), Gaps = 10/99 (10%) Query: 104 DPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLR 163 D + WY G M AE++L + + TFLVR+ + +F +S+ + + Sbjct: 5 DLSVHLWYAGPMERAGAESILANRSDG-TFLVRQRVKDAAEFAISIKYN---------VE 54 Query: 164 VTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEA 202 V HIK+M G Y + + F LT+LVE +++ +++ Sbjct: 55 VKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDC 93 >6AMW-A nrPDB Length = 255 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 146 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 204 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 205 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 235 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 13/96 (13%) Query: 99 PLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGP 158 P+N + S WYHG +S AE LL + G +FLVRES S PG +S+ + Sbjct: 137 PVNSLEKHS--WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG----- 188 Query: 159 GSPLRVTHIKV-MCEGGRYTVGGLETFDSLTDLVEH 193 RV H ++ G+ V F++L +LV H Sbjct: 189 ----RVYHYRINTASDGKLYVSSESRFNTLAELVHH 220 >2ABL-A nrPDB Length = 163 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 72 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 130 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 131 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 161 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/104 (32%), Positives = 46/104 (44%), Gaps = 15/104 (14%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 WYHG +S AE LL + G +FLVRES S PG +S+ + RV H ++ Sbjct: 72 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG---------RVYHYRI 121 Query: 170 -MCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 G+ V F++L +LV H A G L P Sbjct: 122 NTASDGKLYVSSESRFNTLAELVHHHSTV----ADGLITTLHYP 161 >2AUG-A nrPDB Length = 126 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 31/89 (34%), Positives = 49/89 (55%), Gaps = 6/89 (6%) Query: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI---QNSGD 59 WFH +S +A+ L+ +G V G FL R S+ N F LS+ G ++ H +I ++ G+ Sbjct: 28 WFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGE 87 Query: 60 FYDLY--GGEKFATLTELVEYYTQQQGVL 86 + G +F L +LVE+Y +GVL Sbjct: 88 MFHTLDDGHTRFTDLIQLVEFYQLNKGVL 116 Score = 33.5 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 1/48 (2%) Query: 107 SERWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQ 153 S+ W+H +S +A+ L+ +G FLVR+S S P FVLS+ Q Sbjct: 25 SQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQ 72 >1K9A-A nrPDB Length = 450 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 33/103 (32%), Positives = 50/103 (48%), Gaps = 14/103 (13%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 W+HG ++ QAE LL E FLVRES + PGD+ L V + +V H ++ Sbjct: 82 WFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSCEG---------KVEHYRI 131 Query: 170 MCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 M + ++ F++L LVEH+ +A G L +P Sbjct: 132 MYHASKLSIDEEVYFENLMQLVEHYTT----DADGLCTRLIKP 170 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 32/99 (32%), Positives = 42/99 (42%), Gaps = 7/99 (7%) Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 ++ WFH ++ AE LL G FL R S GD++L V +V H RI Sbjct: 79 LMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASK 137 Query: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 + F L +LVE+YT D DG L P Sbjct: 138 LSIDEEVYFENLMQLVEHYT------TDADGLCTRLIKP 170 >2PLE-A nrPDB Length = 105 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/98 (28%), Positives = 47/98 (47%), Gaps = 8/98 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H L+ AE +L G+FL R R +++S R ++ H R+Q G L Sbjct: 11 WYHASLTRAQAEHMLMRVPRDGAFLVR-KRNEPNSYAISFRAEGKIKHCRVQQEGQTVML 69 Query: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 G +F +L +L+ YY + + + L+YP+N Sbjct: 70 -GNSEFDSLVDLISYYEKHPLYRK------MKLRYPIN 100 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 27/90 (30%), Positives = 46/90 (51%), Gaps = 11/90 (12%) Query: 107 SERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTH 166 S+ WYH ++ QAE +L FLVR+ ++P + +S ++ ++ H Sbjct: 8 SKEWYHASLTRAQAEHMLMRVPRDGAFLVRKR-NEPNSYAISFRAEG---------KIKH 57 Query: 167 IKVMCEGGRYTVGGLETFDSLTDLVEHFKK 196 +V EG +G E FDSL DL+ +++K Sbjct: 58 CRVQQEGQTVMLGNSE-FDSLVDLISYYEK 86 >1MIL-A nrPDB Length = 104 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 26/49 (53%), Positives = 33/49 (67%), Gaps = 4/49 (8%) Query: 108 ERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVL-SDQPK 155 E W+HG +S +AE LLQ G+ FLVRES + PG +VL+ L S QPK Sbjct: 7 EPWFHGKLSRREAEALLQLNGD---FLVRESTTTPGQYVLTGLQSGQPK 52 Score = 31.6 bits (70), Expect = 1.0, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 36/76 (47%), Gaps = 4/76 (5%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 WFH LS +AE LL+ ++G FL R S G + L+ Q H+ + + Sbjct: 9 WFHGKLSRREAEALLQ---LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVR- 64 Query: 64 YGGEKFATLTELVEYY 79 +F +++ L+ Y+ Sbjct: 65 TKDHRFESVSHLISYH 80 >3RO1-A nrPDB Length = 161 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 31/91 (34%), Positives = 48/91 (52%), Gaps = 15/91 (16%) Query: 418 PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477 PD GVPS+ + +++++ +L VHC GIGRTGTI+ +++ T+G Sbjct: 68 PDGGVPSDSQFLTIMKWLLSEKEGNL-------VHCVGGIGRTGTILASYLIL----TEG 116 Query: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFI 508 L +++ I VR R G VQT Q F+ Sbjct: 117 L----EVESAIDEVRLVRPGAVQTYEQEMFL 143 >2KK6-A nrPDB Length = 116 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 24/49 (48%), Positives = 35/49 (71%), Gaps = 4/49 (8%) Query: 105 PTSER-WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSD 152 P +E+ WYHG + +A+ LL+ +G+ FLVRES +PG++VLSV SD Sbjct: 13 PLAEQDWYHGAIPRIEAQELLKKQGD---FLVRESHGKPGEYVLSVYSD 58 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 47/91 (51%), Gaps = 4/91 (4%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H + ++A+ LLK +G FL R S G++ LSV Q H IQ + Y Sbjct: 19 WYHGAIPRIEAQELLKKQG---DFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYR- 74 Query: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTII 94 + G F+ + +L++++ + V+ + G ++ Sbjct: 75 FEGTGFSNIPQLIDHHYTTKQVITKKSGVVL 105 >2LQW-A nrPDB Length = 303 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 31/86 (36%), Positives = 44/86 (51%), Gaps = 10/86 (11%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 WY G +S +A+T LQ + FLVR+S + PGD+VLSV + RV+H + Sbjct: 14 WYMGPVSRQEAQTRLQGQRH-GMFLVRDSSTCPGDYVLSVSENS---------RVSHYII 63 Query: 170 MCEGGRYTVGGLETFDSLTDLVEHFK 195 R G + FD L L+E +K Sbjct: 64 NSLPNRRFKIGDQEFDHLPALLEFYK 89 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 1/76 (1%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+ +S +A+T L+G+ HG FL R S GD+ LSV +V+H I + + Sbjct: 14 WYMGPVSRQEAQTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFK 72 Query: 64 YGGEKFATLTELVEYY 79 G ++F L L+E+Y Sbjct: 73 IGDQEFDHLPALLEFY 88 >6DR7-A nrPDB Length = 306 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 102/229 (44%), Gaps = 40/229 (17%) Query: 302 INANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRV--IVMTTREVEKGRN 359 +NANYI+ +G N +T IA Q L++ + ++M + + V ++ ++ E+ R Sbjct: 82 LNANYIQ---VG---NTRT-IACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRF 134 Query: 360 KCVPYWPEVGMQRAYGPYSVTN-----CGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQY 414 Y+ + G YG +V + G D + TL + + + H Sbjct: 135 GMPDYFRQSG---TYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVT- 190 Query: 415 LSWPDHGVP-SEPGGVL-SFLDQINQRQESLPHAG------------PIIVHCSAGIGRT 460 +WPD GVP SE L S +DQ + + ++ + P+I HC AG+GRT Sbjct: 191 -TWPDFGVPESEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVI-HCRAGVGRT 248 Query: 461 GTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSG-MVQTEAQYKFI 508 +I M M + + + ++ + +R QR+G MVQ + Q + Sbjct: 249 AQLIGA-MCMND----SRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVL 292 >4M4Z-A nrPDB Length = 170 Score = 43.9 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 6/92 (6%) Query: 107 SERWYHGHMSGGQAETLLQAKGEPW-TFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 S W + +S +AE LL G P FL+RES ++ G + LSV + P S R+ Sbjct: 68 SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSR----PASWDRIR 123 Query: 166 HIKVMC-EGGRYTVGGLETFDSLTDLVEHFKK 196 H ++ C + G + TF SL LV+H+ + Sbjct: 124 HYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 155 Score = 38.5 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 30/86 (34%), Positives = 46/86 (53%), Gaps = 9/86 (10%) Query: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVG-----DQVTHIRIQ-- 55 W + LS AE LL G G+FL R S+ +G +SLSVR+ D++ H RI Sbjct: 71 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 130 Query: 56 NSGDFYDLYGGEKFATLTELVEYYTQ 81 ++G Y + F +L LV++Y++ Sbjct: 131 DNGWLY-ISPRLTFPSLQALVDHYSE 155 >5U06-A nrPDB Length = 120 Score = 42.7 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 30/89 (33%), Positives = 47/89 (52%), Gaps = 6/89 (6%) Query: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 WFH +S +++ L+ +G V G FL R S++N F LS+ +V H I S + Sbjct: 19 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 78 Query: 63 LY-----GGEKFATLTELVEYYTQQQGVL 86 LY G +F L +LVE++ +G+L Sbjct: 79 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 107 Score = 33.5 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 17/44 (38%), Positives = 27/44 (61%), Gaps = 1/44 (2%) Query: 107 SERWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSV 149 ++ W+HG +S +++ L+ +G FLVRES P FVLS+ Sbjct: 16 TQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSL 59 >4FL3-A nrPDB Length = 635 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 45/79 (56%), Gaps = 3/79 (3%) Query: 4 WFHRDLSGLDAETL-LKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGDFY 61 WFH +S ++E + L G +G FL R +R N G ++L + +V H RI ++ Sbjct: 168 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKL 226 Query: 62 DLYGGEKFATLTELVEYYT 80 + G+KF TL +LVE+Y+ Sbjct: 227 SIPEGKKFDTLWQLVEHYS 245 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 8/100 (8%) Query: 4 WFHRDLSGLDAET-LLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNS-GDFY 61 +F +++ +AE L++G G +L R SR G F+LSV G + H I+ Y Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 Query: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 + GG A+ +L Y++Q+ DG + LK P N Sbjct: 75 AIAGGRTHASPADLCHYHSQES------DGLVCLLKKPFN 108 >2EKX-A nrPDB Length = 110 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 7/103 (6%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 W+ G++S Q+E LL+ KG+ F+VR S SQ G + +S+ S G+ ++ H+ Sbjct: 13 WFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGT-VKHYHVHT 70 Query: 170 MCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 E Y FDS+ L+ + + ++G LR P Sbjct: 71 NAENKLYLAENY-CFDSIPKLIHYHQ----HNSAGMITRLRHP 108 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 52/106 (49%), Gaps = 16/106 (15%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSV---RVGDQ---VTHIRIQNS 57 WF ++S +E LL+ +G G+F+ R S + G +++S+ V D+ V H + + Sbjct: 13 WFAGNISRSQSEQLLRQKGKEGAFMVRNSSQ-VGMYTVSLFSKAVNDKKGTVKHYHVHTN 71 Query: 58 GDFYDLYGGEK--FATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 + LY E F ++ +L+ Y+ G I L++P++ Sbjct: 72 AE-NKLYLAENYCFDSIPKLIHYHQHNSA------GMITRLRHPVS 110 >2EOB-A nrPDB Length = 124 Score = 42.0 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 34/114 (29%), Positives = 51/114 (44%), Gaps = 10/114 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W++ LS +AE +L G+FL R R+ ++++ R +V H RI G + L Sbjct: 21 WYYDRLSRGEAEDMLMRIPRDGAFLIR-KREGTDSYAITFRARGKVKHCRINRDGRHFVL 79 Query: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSG 117 F +L ELV YY + + R L+YP+ P Y G SG Sbjct: 80 GTSAYFESLVELVSYYEKHALYRKMR------LRYPVT---PELLERYSGPSSG 124 Score = 32.7 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 22/90 (24%), Positives = 42/90 (46%), Gaps = 10/90 (11%) Query: 107 SERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTH 166 S+ WY+ +S G+AE +L FL+R+ +D + +V H Sbjct: 18 SKPWYYDRLSRGEAEDMLMRIPRDGAFLIRKREG----------TDSYAITFRARGKVKH 67 Query: 167 IKVMCEGGRYTVGGLETFDSLTDLVEHFKK 196 ++ +G + +G F+SL +LV +++K Sbjct: 68 CRINRDGRHFVLGTSAYFESLVELVSYYEK 97 >6F3F-A nrPDB Length = 455 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 33/92 (35%), Positives = 48/92 (52%), Gaps = 6/92 (6%) Query: 107 SERWYHGHMSGGQAE-TLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 +E WY G ++ ++E LL A+ TFLVRES + G + LSV SD A L V Sbjct: 67 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNA---KGLNVK 122 Query: 166 HIKVM-CEGGRYTVGGLETFDSLTDLVEHFKK 196 H K+ + G + + F+SL LV ++ K Sbjct: 123 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK 154 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 9/104 (8%) Query: 4 WFHRDLSGLDAE-TLLKGRGVHGSFLARPSRKNQGDFSLSVRVGD-----QVTHIRIQ-- 55 W+ ++ ++E LL G+FL R S +G + LSV D V H +I+ Sbjct: 70 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 129 Query: 56 NSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 +SG FY + +F +L +LV YY++ L R T+ P Sbjct: 130 DSGGFY-ITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKP 172 >1A81-A nrPDB Length = 254 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 45/79 (56%), Gaps = 3/79 (3%) Query: 4 WFHRDLSGLDAETL-LKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGDFY 61 WFH +S ++E + L G +G FL R +R N G ++L + +V H RI ++ Sbjct: 160 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKL 218 Query: 62 DLYGGEKFATLTELVEYYT 80 + G+KF TL +LVE+Y+ Sbjct: 219 SIPEGKKFDTLWQLVEHYS 237 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 8/100 (8%) Query: 4 WFHRDLSGLDAET-LLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNS-GDFY 61 +F +++ +AE L++G G +L R SR G F+LSV G + H I+ Y Sbjct: 7 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 66 Query: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 + GG A+ +L Y++Q+ DG + LK P N Sbjct: 67 AIAGGRTHASPADLCHYHSQES------DGLVCLLKKPFN 100 >1NRV-A nrPDB Length = 105 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 6/89 (6%) Query: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGD--- 59 WFH +S ++ ++K +G V G FL R S+ N F L++ ++ + +I D Sbjct: 7 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 66 Query: 60 -FYDLY-GGEKFATLTELVEYYTQQQGVL 86 F+ L G KF+ L +LV++Y +GVL Sbjct: 67 TFFSLDDGNTKFSDLIQLVDFYQLNKGVL 95 Score = 32.7 bits (73), Expect = 0.45, Method: Composition-based stats. Identities = 15/48 (31%), Positives = 29/48 (60%), Gaps = 1/48 (2%) Query: 107 SERWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQ 153 ++ W+HG +S ++ +++ +G FL+R+S S P FVL++ Q Sbjct: 4 TQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQ 51 >2H8H-A nrPDB Length = 535 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/92 (33%), Positives = 46/92 (50%), Gaps = 6/92 (6%) Query: 107 SERWYHGHMSGGQAE-TLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 +E WY G ++ ++E LL A+ TFLVRES + G + LSV G L V Sbjct: 147 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG----LNVK 202 Query: 166 HIKVM-CEGGRYTVGGLETFDSLTDLVEHFKK 196 H K+ + G + + F+SL LV ++ K Sbjct: 203 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK 234 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 9/104 (8%) Query: 4 WFHRDLSGLDAE-TLLKGRGVHGSFLARPSRKNQGDFSLSVR-----VGDQVTHIRIQ-- 55 W+ ++ ++E LL G+FL R S +G + LSV G V H +I+ Sbjct: 150 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 209 Query: 56 NSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 +SG FY + +F +L +LV YY++ L R T+ P Sbjct: 210 DSGGFY-ITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKP 252 >4XI2-A nrPDB Length = 446 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 44/86 (51%), Gaps = 7/86 (8%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 WY HM+ QAE LL+ +G+ F+VR+S S+ G + +SV + G P V V Sbjct: 68 WYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAK----STGEPQGVIRHYV 122 Query: 170 MCEG--GRYTVGGLETFDSLTDLVEH 193 +C +Y + F ++ +L+ + Sbjct: 123 VCSTPQSQYYLAEKHLFSTIPELINY 148 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 14/108 (12%) Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSV---RVGDQVTHIR--IQ 55 M W+ + ++ AE LLK G G F+ R S K G +++SV G+ IR + Sbjct: 65 MYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSK-AGKYTVSVFAKSTGEPQGVIRHYVV 123 Query: 56 NSGDFYDLYGGEK--FATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 S Y EK F+T+ EL+ Y+ G I LKYP++ Sbjct: 124 CSTPQSQYYLAEKHLFSTIPELINYHQHNSA------GLISRLKYPVS 165 >3F41-A nrPDB Length = 629 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 5/81 (6%) Query: 411 HYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLM 470 +Y L+ DH P +P +D+ + +SLP + HC AG+GRT +V+ ++ Sbjct: 202 NYFRLTLQDHFRPDDPD-----VDKFLEFYKSLPKDAWLHYHCYAGMGRTTIFMVMHDIL 256 Query: 471 ENISTKGLDCDIDIQKTIQMV 491 +N D I QK I +V Sbjct: 257 KNAKDVSFDDIIQRQKLIGIV 277 Score = 31.6 bits (70), Expect = 0.90, Method: Compositional matrix adjust. Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 5/62 (8%) Query: 411 HYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLM 470 HY ++ DH PS +D+ ++P + HC AG GRT + + +M Sbjct: 500 HYYRIAATDHIWPSAAN-----IDEFINFTRTMPANAWLHFHCQAGAGRTTAYMAMYDMM 554 Query: 471 EN 472 +N Sbjct: 555 KN 556 >2CS0-A nrPDB Length = 119 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/81 (34%), Positives = 43/81 (53%), Gaps = 4/81 (4%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 WFH +S DAE LL+ + + GSFL R S + G ++LS + H ++ D + Sbjct: 18 WFHGAISREDAENLLESQPL-GSFLIRVSHSHVG-YTLSYKAQSSCCHFMVKLLDDGTFM 75 Query: 64 YGGEKFA--TLTELVEYYTQQ 82 GEK A +L LV ++ Q+ Sbjct: 76 IPGEKVAHTSLDALVTFHQQK 96 >2EYZ-A nrPDB Length = 304 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 42/130 (32%), Positives = 55/130 (42%), Gaps = 39/130 (30%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 WY G +S +A LLQ + FLVR+S + PGD+VLSV + RV+H + Sbjct: 13 WYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENS---------RVSHYII 62 Query: 170 M------------------CEGGRYTVGGLETFDSLTDLVEHFK------KTGIEEAS-- 203 R +G E FDSL L+E +K T IE S Sbjct: 63 NSSGPRPPVPPSPAQPPPGVSPSRLRIGDQE-FDSLPALLEFYKIHYLDTTTLIEPVSRS 121 Query: 204 --GAFVYLRQ 211 G+ V LRQ Sbjct: 122 RQGSGVILRQ 131 Score = 35.4 bits (80), Expect = 0.073, Method: Compositional matrix adjust. Identities = 21/51 (41%), Positives = 29/51 (56%), Gaps = 1/51 (1%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI 54 W+ LS +A LL+G+ HG FL R S + GD+ LSV +V+H I Sbjct: 13 WYWGRLSRQEAVALLQGQ-RHGVFLVRDSSTSPGDYVLSVSENSRVSHYII 62 >4GL9-E nrPDB Length = 143 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 19/93 (20%) Query: 110 WYHGHMSGGQAETLLQAKGEPW-TFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 168 +Y ++GG+A LL A EP TFL+R+S Q F LSV K G+ +++ Sbjct: 30 FYWSAVTGGEANLLLSA--EPAGTFLIRDSSDQRHFFTLSV-----KTQSGT----KNLR 78 Query: 169 VMCEGGRYTVGG-------LETFDSLTDLVEHF 194 + CEGG +++ + FD + LV H+ Sbjct: 79 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 111 Score = 29.3 bits (64), Expect = 5.1, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 10/108 (9%) Query: 9 LSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGG-- 66 ++G +A LL G+FL R S + F+LSV+ ++RIQ G + L Sbjct: 35 VTGGEANLLLSAEPA-GTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPR 93 Query: 67 -----EKFATLTELVEYYTQQQGVLQDRDGTIIH--LKYPLNCSDPTS 107 +F + +LV +Y R I K PL S P S Sbjct: 94 STQPVPRFDCVLKLVHHYMGSGSGSGSRAYYIYSGGEKIPLVLSRPLS 141 >6C7Y-B nrPDB Length = 117 Score = 38.5 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 11/86 (12%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 +Y G ++ A L+++ E TFL+R+S + F +SV + GP T I++ Sbjct: 28 FYWGPLTVSAAHEKLKSEPEG-TFLIRDSTQKNCFFAISV---KTATGP------TSIRI 77 Query: 170 MCEGGRYTV-GGLETFDSLTDLVEHF 194 + GR+++ G ETFD L L+EH+ Sbjct: 78 NFQTGRFSLDGSKETFDCLFKLLEHY 103 Score = 31.6 bits (70), Expect = 0.92, Method: Composition-based stats. Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 1/56 (1%) Query: 25 GSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGG-EKFATLTELVEYY 79 G+FL R S + F++SV+ T IRI + L G E F L +L+E+Y Sbjct: 48 GTFLIRDSTQKNCFFAISVKTATGPTSIRINFQTGRFSLDGSKETFDCLFKLLEHY 103 >4ERC-A nrPDB Length = 150 Score = 38.1 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 18/98 (18%) Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482 P + + +D+ N R E+ + VHC+ G GRTGT++ ++ E G Sbjct: 71 PDQIDRFVQIVDEANARGEA------VGVHCALGFGRTGTMLACYLVKERGLAAG----- 119 Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK 520 I +R R G ++T Q K A+ QF + TK Sbjct: 120 ---DAIAEIRRLRPGSIETYEQEK----AVFQFYQRTK 150 >2HMH-A nrPDB Length = 152 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 19/93 (20%) Query: 110 WYHGHMSGGQAETLLQAKGEPW-TFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 168 +Y ++GG+A LL A EP TFL+R+S Q F LSV K G+ +++ Sbjct: 36 FYWSAVTGGEANLLLSA--EPAGTFLIRDSSDQRHFFTLSV-----KTQSGT----KNLR 84 Query: 169 VMCEGGRYTVGG-------LETFDSLTDLVEHF 194 + CEGG +++ + FD + LV H+ Sbjct: 85 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 117 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 8/89 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 ++ ++G +A LL G+FL R S + F+LSV+ ++RIQ G + L Sbjct: 36 FYWSAVTGGEANLLLSAEPA-GTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSL 94 Query: 64 YGG-------EKFATLTELVEYYTQQQGV 85 +F + +LV +Y Q + Sbjct: 95 QSDPRSTQPVPRFDCVLKLVHHYMPPQAL 123 >5Z59-A nrPDB Length = 147 Score = 38.1 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 24/91 (26%), Positives = 47/91 (51%), Gaps = 12/91 (13%) Query: 418 PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477 PD PS V L+ + +E + +++HC G+GR+GT+ V ++ ++G Sbjct: 62 PDFTAPS----VEQLLEILRWIEERVREGKKVLIHCMGGLGRSGTVGVAWLMY----SRG 113 Query: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFI 508 L +++ + VR +R G V+T+ Q + + Sbjct: 114 L----SLREALMEVRRKRPGAVETQEQMEVL 140 >2BBU-A nrPDB Length = 164 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 48/93 (51%), Gaps = 19/93 (20%) Query: 110 WYHGHMSGGQAETLLQAKGEPW-TFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 168 +Y ++GG+A LL A EP TFL+R+S Q F LSV + ++G +++ Sbjct: 25 FYWSAVTGGEANLLLSA--EPAGTFLIRDSSDQRHFFTLSVKT---QSG------TKNLR 73 Query: 169 VMCEGGRYTVGG-------LETFDSLTDLVEHF 194 + CEGG +++ + FD + LV H+ Sbjct: 74 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 106 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 8/89 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 ++ ++G +A LL G+FL R S + F+LSV+ ++RIQ G + L Sbjct: 25 FYWSAVTGGEANLLLSAEPA-GTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSL 83 Query: 64 YGG-------EKFATLTELVEYYTQQQGV 85 +F + +LV +Y G Sbjct: 84 QSDPRSTQPVPRFDCVLKLVHHYMPPPGT 112 >5K23-A nrPDB Length = 189 Score = 37.7 bits (86), Expect = 0.013, Method: Compositional matrix adjust. Identities = 21/89 (23%), Positives = 40/89 (44%), Gaps = 11/89 (12%) Query: 415 LSWP-DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENI 473 L WP D G P V +L+ + + P + VHC AG+GR ++ + + Sbjct: 85 LDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCC-VAVHCVAGLGRAPVLVALAL----- 138 Query: 474 STKGLDCDIDIQKTIQMVRAQRSGMVQTE 502 ++C + + +Q +R +R G ++ Sbjct: 139 ----IECGMKYEDAVQFIRQKRRGAFNSK 163 >1OHC-A nrPDB Length = 348 Score = 37.7 bits (86), Expect = 0.016, Method: Compositional matrix adjust. Identities = 30/85 (35%), Positives = 39/85 (45%), Gaps = 15/85 (17%) Query: 415 LSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENIS 474 L + D P++ V FLD I + E G I VHC AG+GRTGT+I ++ Sbjct: 245 LFFADGSTPTD-AIVKEFLD-ICENAE-----GAIAVHCKAGLGRTGTLIACYIMKHYRM 297 Query: 475 TKGLDCDIDIQKTIQMVRAQRSGMV 499 T +TI VR R G V Sbjct: 298 TAA--------ETIAWVRICRPGSV 314 >3S4O-A nrPDB Length = 167 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 33/97 (34%), Positives = 45/97 (46%), Gaps = 15/97 (15%) Query: 416 SWP-DHGVPSEPGGV---LSFLDQINQRQESLPHAGP--IIVHCSAGIGRTGTIIVIDML 469 SWP D G P + L LD RQ+ P P I VHC AG+GR I+V L Sbjct: 73 SWPFDDGAPPTRAVLDSWLKLLDTELARQQEDPSVPPPTIGVHCVAGLGR-APILVALAL 131 Query: 470 MENISTKGLDCDIDIQKTIQMVRAQRSGMV-QTEAQY 505 +E + LD I ++R +R G + QT+ + Sbjct: 132 VEYGNVSALD-------AIALIREKRKGAINQTQMHW 161 >2HDV-A nrPDB Length = 111 Score = 36.6 bits (83), Expect = 0.031, Method: Composition-based stats. Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 2/53 (3%) Query: 4 WFHRDLSGLDAETLL--KGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI 54 WFH LS L A L+ G G HG FL R S +G+ L+ + H+R+ Sbjct: 11 WFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHLRL 63 >6C5X-D nrPDB Length = 164 Score = 36.6 bits (83), Expect = 0.033, Method: Composition-based stats. Identities = 20/56 (35%), Positives = 32/56 (57%), Gaps = 1/56 (1%) Query: 25 GSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGG-EKFATLTELVEYY 79 G+FL R S++ F++SV+ + IRI+ + L G E F+ L +LVE+Y Sbjct: 52 GTFLIRDSKQKNCFFAISVKTARETVSIRIKFHAGKFSLDGSKELFSCLFQLVEHY 107 >3CXL-A nrPDB Length = 463 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 4/74 (5%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 R FH +S A+ LL GS+L R S++ G ++L++R G Q + R+ G + Sbjct: 52 REFHGMISREAADQLLIV--AEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHF- 108 Query: 63 LYGGEKFATLTELV 76 G ++F ++ +LV Sbjct: 109 -VGEKRFESIHDLV 121 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 27/84 (32%), Positives = 45/84 (53%), Gaps = 15/84 (17%) Query: 109 RWYHGHMSGGQAETLL-QAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHI 167 R +HG +S A+ LL A+G ++L+RES QPG + L++ GS R + Sbjct: 52 REFHGMISREAADQLLIVAEG---SYLIRESQRQPGTYTLALRF-------GSQTR--NF 99 Query: 168 KVMCEGGRYTVGGLETFDSLTDLV 191 ++ +G + G + F+S+ DLV Sbjct: 100 RLYYDGKHFV--GEKRFESIHDLV 121 >5K22-A nrPDB Length = 183 Score = 36.2 bits (82), Expect = 0.042, Method: Compositional matrix adjust. Identities = 21/89 (23%), Positives = 40/89 (44%), Gaps = 11/89 (12%) Query: 415 LSWP-DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENI 473 L WP D G P V +L+ + + P A + VHC AG+GR ++ + + Sbjct: 83 LDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGAA-VAVHCVAGLGRAPVLVALAL----- 136 Query: 474 STKGLDCDIDIQKTIQMVRAQRSGMVQTE 502 ++ + + +Q +R +R G ++ Sbjct: 137 ----IEAGMKYEDAVQFIRQKRRGAFNSK 161 >1KA6-A nrPDB Length = 128 Score = 35.0 bits (79), Expect = 0.081, Method: Compositional matrix adjust. Identities = 18/40 (45%), Positives = 24/40 (60%) Query: 111 YHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVL 150 YHG +S E LL A G ++L+R+S S PG + L VL Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVL 46 >5XW4-A nrPDB Length = 415 Score = 35.0 bits (79), Expect = 0.083, Method: Compositional matrix adjust. Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 8/53 (15%) Query: 447 GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMV 499 G I VHC AG+GRTG +I + I T G + + I +R R GMV Sbjct: 318 GKIAVHCKAGLGRTGCLIGAHL----IYTYGFTAN----ECIGFLRFIRPGMV 362 >5M6U-B nrPDB Length = 724 Score = 35.0 bits (79), Expect = 0.091, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 43/91 (47%), Gaps = 11/91 (12%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRE-SLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 168 WY G +S + L+ + TFLVR+ S GD+ L++ + G + L IK Sbjct: 333 WYWGDISREEVNEKLRDTADG-TFLVRDASTKMHGDYTLTL-----RKGGNNKL----IK 382 Query: 169 VMCEGGRYTVGGLETFDSLTDLVEHFKKTGI 199 + G+Y TF S+ +L+ H++ + Sbjct: 383 IFHRDGKYGFSDPLTFSSVVELINHYRNESL 413 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 26/99 (26%), Positives = 48/99 (48%), Gaps = 3/99 (3%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLAR-PSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 W+ D+S + L+ G+FL R S K GD++L++R G I+I + Y Sbjct: 333 WYWGDISREEVNEKLRDTA-DGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYG 391 Query: 63 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 F+++ EL+ +Y + + + Q + L YP++ Sbjct: 392 FSDPLTFSSVVELINHY-RNESLAQYNPKLDVKLLYPVS 429 >4NX8-A nrPDB Length = 293 Score = 35.0 bits (79), Expect = 0.10, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 5/68 (7%) Query: 412 YQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLME 471 Y L+ DH P V S +D+ + +LP + HC AG GRT T +V+ +++ Sbjct: 170 YVRLTVTDHVRP-----VDSEVDRFIESVRALPENAWVHFHCRAGKGRTTTFMVLYDMLK 224 Query: 472 NISTKGLD 479 N T + Sbjct: 225 NAKTDSFE 232 >1M27-A nrPDB Length = 104 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 18/40 (45%), Positives = 24/40 (60%) Query: 111 YHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVL 150 YHG +S E LL A G ++L+R+S S PG + L VL Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVL 46 >2RF6-A nrPDB Length = 176 Score = 34.7 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 15/44 (34%), Positives = 28/44 (63%), Gaps = 6/44 (13%) Query: 429 VLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMEN 472 V +FL + +QR E P++VH +AG+ R+G +I+ ++ +N Sbjct: 97 VTAFLSKCDQRNE------PVLVHSAAGVNRSGAMILAYLMSKN 134 >1RPY-A nrPDB Length = 114 Score = 33.9 bits (76), Expect = 0.23, Method: Composition-based stats. Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 13/99 (13%) Query: 110 WYHGHMSGGQAETLLQAKG--EPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHI 167 W+HG +S +A L+ A G F++R+S ++PG+ VL+ + Q KA H+ Sbjct: 13 WFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLT-FNFQGKA--------KHL 63 Query: 168 KVMCEG-GRYTVGGLETFDSLTDLVEHFKKTGIEEASGA 205 ++ G G+ V L F S+ D++ HF I SG Sbjct: 64 RLSLNGHGQCHVQHL-WFQSVFDMLRHFHTHPIPLESGG 101 Score = 30.8 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 18/57 (31%), Positives = 27/57 (47%), Gaps = 2/57 (3%) Query: 4 WFHRDLSGLDAETLLKGRG--VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSG 58 WFH LS + A L+ G HG F+ R S G+ L+ + H+R+ +G Sbjct: 13 WFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNG 69 >1V3A-A nrPDB Length = 173 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 43/90 (47%), Gaps = 13/90 (14%) Query: 415 LSWP-DHGVPSEPGGVL-SFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMEN 472 + WP D G P PG V+ +L + + P + + VHC AG+GR ++ + + Sbjct: 66 VDWPFDDGAPP-PGKVVEDWLSLVKAKFCEAPGSC-VAVHCVAGLGRAPVLVALAL---- 119 Query: 473 ISTKGLDCDIDIQKTIQMVRAQRSGMVQTE 502 ++ + + IQ +R +R G + ++ Sbjct: 120 -----IESGMKYEDAIQFIRQKRRGAINSK 144 >2OZ5-A nrPDB Length = 296 Score = 33.1 bits (74), Expect = 0.37, Method: Compositional matrix adjust. Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 12/70 (17%) Query: 438 QRQESLPHAG-PIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDI------QKTIQM 490 R +L AG P++ HC AG RTG V+ +++E + GLD D+ + ++ Sbjct: 164 HRVVTLLAAGRPVLTHCFAGKDRTG--FVVALVLEAV---GLDRDVIVADYLRSNDSVPQ 218 Query: 491 VRAQRSGMVQ 500 +RA+ S M+Q Sbjct: 219 LRARISEMIQ 228 >2WGP-A nrPDB Length = 190 Score = 32.7 bits (73), Expect = 0.42, Method: Compositional matrix adjust. Identities = 15/59 (25%), Positives = 32/59 (54%), Gaps = 3/59 (5%) Query: 412 YQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA-GPIIVHCSAGIGRTGTIIVIDML 469 ++Y+ P +P P G+ + D + + S+ G +VHC+AG+ R+ T+ + ++ Sbjct: 70 FEYVKVPLADMPHAPIGL--YFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM 126 >3D1Q-A nrPDB Length = 340 Score = 32.7 bits (73), Expect = 0.45, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 24/48 (50%) Query: 433 LDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480 +D+ +LP + HC AG+GRT +V+ +++N S D Sbjct: 226 IDRFLAFYRTLPQDAWLHFHCEAGVGRTTAFMVMTDMLKNPSVSLKDI 273 >5LXQ-B nrPDB Length = 196 Score = 32.3 bits (72), Expect = 0.56, Method: Compositional matrix adjust. Identities = 21/89 (23%), Positives = 38/89 (42%), Gaps = 11/89 (12%) Query: 415 LSWP-DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENI 473 L WP D G P V +L + + P I VHC AG+GR ++ + + Sbjct: 89 LDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCC-IAVHCVAGLGRAPVLVALAL----- 142 Query: 474 STKGLDCDIDIQKTIQMVRAQRSGMVQTE 502 ++ + + +Q +R +R G ++ Sbjct: 143 ----IEGGMKYEDAVQFIRQKRRGAFNSK 167 >2VIF-A nrPDB Length = 141 Score = 32.3 bits (72), Expect = 0.60, Method: Compositional matrix adjust. Identities = 24/89 (26%), Positives = 40/89 (44%), Gaps = 6/89 (6%) Query: 25 GSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSG---DFYDLYGGEKFATLTELVEYY-- 79 GSFL R S ++ SLS R + H RI++S FY+ E ++ +L+E+ Sbjct: 46 GSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIG 105 Query: 80 -TQQQGVLQDRDGTIIHLKYPLNCSDPTS 107 ++ R YP+ ++P S Sbjct: 106 DSENGAFCYSRSRLPGSATYPVRLTNPVS 134 >3RZ2-A nrPDB Length = 189 Score = 32.0 bits (71), Expect = 0.79, Method: Compositional matrix adjust. Identities = 21/89 (23%), Positives = 38/89 (42%), Gaps = 11/89 (12%) Query: 415 LSWP-DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENI 473 L WP D G P V +L + + P I VHC AG+GR ++ + + Sbjct: 86 LDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCC-IAVHCVAGLGRAPVLVALAL----- 139 Query: 474 STKGLDCDIDIQKTIQMVRAQRSGMVQTE 502 ++ + + +Q +R +R G ++ Sbjct: 140 ----IEGGMKYEDAVQFIRQKRRGAFNSK 164 >4R0S-A nrPDB Length = 218 Score = 32.0 bits (71), Expect = 0.81, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 29/67 (43%), Gaps = 8/67 (11%) Query: 413 QYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMEN 472 + LS P H + VLS L Q+ + GP+++HC G RTG M Sbjct: 96 RVLSLPTHADRVDDAEVLSVLRQLQAAERE----GPVLMHCKHGNNRTGLFAA----MYR 147 Query: 473 ISTKGLD 479 I +G D Sbjct: 148 IVVQGWD 154 >1ZCK-A nrPDB Length = 154 Score = 32.0 bits (71), Expect = 0.83, Method: Compositional matrix adjust. Identities = 21/89 (23%), Positives = 38/89 (42%), Gaps = 11/89 (12%) Query: 415 LSWP-DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENI 473 L WP D G P V +L + + P I VHC AG+GR ++ + + Sbjct: 60 LDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCC-IAVHCVAGLGRAPVLVALAL----- 113 Query: 474 STKGLDCDIDIQKTIQMVRAQRSGMVQTE 502 ++ + + +Q +R +R G ++ Sbjct: 114 ----IEGGMKYEDAVQFIRQKRRGAFNSK 138 >1G4W-R nrPDB Length = 383 Score = 32.0 bits (71), Expect = 0.83, Method: Compositional matrix adjust. Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 16/112 (14%) Query: 416 SWPDHGVPSEPGGVLSFL-DQI-NQRQESLPHAG------PIIVHCSAGIGRTGTIIVID 467 +WPDH P L +L D++ N Q P P+I HC G+GRTGT+ Sbjct: 278 NWPDHQ-PLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMI-HCLGGVGRTGTMAAAL 335 Query: 468 MLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT 519 +L +N + D + + R R M++ +Q+ + AQ + TT Sbjct: 336 VLKDNPHSNLEQVRADFRDS----RNNR--MLEDASQFVQLKAMQAQLLMTT 381 >4JGH-A nrPDB Length = 173 Score = 32.0 bits (71), Expect = 0.86, Method: Compositional matrix adjust. Identities = 29/116 (25%), Positives = 55/116 (47%), Gaps = 14/116 (12%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+ ++ +A+ LK G+FL R S + ++SV+ T++RI+ + L Sbjct: 23 WYWGSMTVNEAKEKLK-EAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRL 81 Query: 64 -------YGGEKFATLTELVEYYTQ-----QQGVLQDRDGTI-IHLKYPLNCSDPT 106 ++F ++ L++YY Q + G R+GT+ ++L PL S P+ Sbjct: 82 DSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPS 137 >2R0B-A nrPDB Length = 154 Score = 31.6 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 2/70 (2%) Query: 442 SLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQT 501 SL G ++VH +AGI R+ VI +ME K D +Q+ + +G V Sbjct: 86 SLQMGGKVLVHGNAGISRSAA-FVIAYIMETFGMKYRDAFAYVQER-RFCINPNAGFVHQ 143 Query: 502 EAQYKFIYVA 511 +Y+ IY+A Sbjct: 144 LQEYEAIYLA 153 >1YN9-A nrPDB Length = 169 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 4/66 (6%) Query: 401 DNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPII-VHCSAGIGR 459 D +R Y+ + P +P E V F+D + + E P G ++ VHC+ GI R Sbjct: 70 DGVHFLRAGLLYKKIQVPGQTLPPE-SIVQEFIDTVKEFTEKCP--GMLVGVHCTHGINR 126 Query: 460 TGTIIV 465 TG ++ Sbjct: 127 TGYMVC 132 >2M3V-A nrPDB Length = 193 Score = 30.4 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 16/47 (34%), Positives = 23/47 (48%), Gaps = 4/47 (8%) Query: 415 LSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTG 461 +S P H + VLS L Q+ + GP+++HC G RTG Sbjct: 73 VSLPTHADRVDDAEVLSVLRQLQAAERE----GPVLMHCKHGNNRTG 115 >5IXI-A nrPDB Length = 544 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 24/102 (23%), Positives = 53/102 (51%), Gaps = 3/102 (2%) Query: 112 HGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLS-DQPKAGPGSPLRVTHIKV 169 HG + A L+ +G E +++R S + + +++V ++ + G+ + + ++ Sbjct: 423 HGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQI 482 Query: 170 MCEGGRYTVGGLE-TFDSLTDLVEHFKKTGIEEASGAFVYLR 210 + GRY++ G + +F SL DL+ H KK + + +F+ R Sbjct: 483 EVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKR 524 >2IZV-A nrPDB Length = 187 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 5/77 (6%) Query: 14 AETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQ--NSGDFYDLYGGEKFAT 71 AE LL+G+ G+FL R S + FS+S R + H RI+ N +D + F + Sbjct: 46 AEALLEGKP-EGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHS 104 Query: 72 --LTELVEYYTQQQGVL 86 +T L+E+Y + Sbjct: 105 PDITGLLEHYKDPSACM 121 >6D67-A nrPDB Length = 520 Score = 30.0 bits (66), Expect = 3.1, Method: Compositional matrix adjust. Identities = 24/91 (26%), Positives = 39/91 (42%), Gaps = 19/91 (20%) Query: 411 HYQYLSWP---DH--GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIV 465 HYQY S P +H + S + F+D I G + VH AGI R+ TI + Sbjct: 417 HYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNA------GGRVFVHSQAGISRSATICL 470 Query: 466 IDMLMENISTKGLDCDIDIQKTIQMVRAQRS 496 ++ N + + + + V+ +RS Sbjct: 471 AYLMRTN--------RVKLDEAFEFVKQRRS 493 >1XA6-A nrPDB Length = 466 Score = 29.6 bits (65), Expect = 4.0, Method: Compositional matrix adjust. Identities = 16/41 (39%), Positives = 25/41 (60%), Gaps = 2/41 (4%) Query: 109 RWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSV 149 R +HG +S QA+ LL G +++RES QPG + L++ Sbjct: 56 REFHGIISREQADELL--GGVEGAYILRESQRQPGCYTLAL 94 >4CRV-B nrPDB Length = 273 Score = 29.6 bits (65), Expect = 4.0, Method: Compositional matrix adjust. Identities = 18/59 (30%), Positives = 27/59 (45%), Gaps = 2/59 (3%) Query: 224 ENRVLELNKKQESEDTAKAGFWEEFESLQK--QEVKNLHQRLEGQRPENKGKNRYKNIL 280 EN +LEL+KK+ES W F ++ QE+ N++ + NR N L Sbjct: 24 ENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNAL 82 >2Q4W-A nrPDB Length = 524 Score = 28.5 bits (62), Expect = 8.8, Method: Compositional matrix adjust. Identities = 22/68 (32%), Positives = 30/68 (44%), Gaps = 2/68 (2%) Query: 8 DLSGLDAETLLKGRGVHG-SFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGG 66 D GL L GV G +F P N + + GD VT I+NS F+ + GG Sbjct: 162 DYLGLTVGGTLSNAGVSGQAFRYGPQTSNVTELDVVTGNGDVVTCSEIENSELFFSVLGG 221 Query: 67 -EKFATLT 73 +F +T Sbjct: 222 LGQFGIIT 229 >2FZ4-A nrPDB Length = 237 Score = 28.5 bits (62), Expect = 9.7, Method: Compositional matrix adjust. Identities = 12/41 (29%), Positives = 22/41 (53%) Query: 189 DLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLE 229 D++E+F+ GIE A + PY+ ++ D + + LE Sbjct: 63 DIIEYFESNGIEFVDNAADPIPTPYFDAEISLRDYQEKALE 103 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3PS5-A nrPDB 926 0.0 2B3O-A nrPDB 812 0.0 4H1O-A nrPDB 716 0.0 6CMQ-A nrPDB 568 e-162 4HJQ-A nrPDB 461 e-130 4PVG-A nrPDB 416 e-116 2JJD-A nrPDB 416 e-116 2OOQ-A nrPDB 400 e-112 3I36-A nrPDB 399 e-111 2C7S-A nrPDB 399 e-111 6D4D-A nrPDB 392 e-109 1LAR-A nrPDB 385 e-107 2CFV-A nrPDB 385 e-107 1YFO-A nrPDB 383 e-106 1RPM-A nrPDB 380 e-106 4BPC-A nrPDB 380 e-105 2NLK-A nrPDB 379 e-105 2NV5-A nrPDB 377 e-105 5AWX-A nrPDB 372 e-103 2PBN-A nrPDB 371 e-103 2H03-A nrPDB 371 e-103 2PI7-A nrPDB 368 e-102 3S3F-A nrPDB 365 e-101 2GJT-A nrPDB 363 e-101 1YGU-A nrPDB 361 e-100 2I75-A nrPDB 357 8e-99 3OLR-A nrPDB 357 9e-99 4IKC-A nrPDB 353 1e-97 4GFV-A nrPDB 350 1e-96 5HDE-A nrPDB 349 2e-96 4BJO-A nrPDB 345 4e-95 4RHG-A nrPDB 342 2e-94 4GE6-A nrPDB 337 1e-92 1P15-A nrPDB 333 2e-91 1ZC0-A nrPDB 332 2e-91 2QEP-A nrPDB 332 3e-91 2BZL-A nrPDB 330 8e-91 2A8B-A nrPDB 329 2e-90 1WCH-A nrPDB 328 6e-90 6D3F-A nrPDB 327 8e-90 2I1Y-A nrPDB 325 4e-89 1L8K-A nrPDB 324 6e-89 5OVR-A nrPDB 323 1e-88 6H8S-A nrPDB 312 2e-85 3M4U-A nrPDB 268 7e-72 4AZ1-A nrPDB 259 3e-69 6DR7-A nrPDB 159 2e-39 1AD5-A nrPDB 131 8e-31 1K9A-A nrPDB 125 6e-29 2EOB-A nrPDB 118 5e-27 4FL3-A nrPDB 116 3e-26 2ABL-A nrPDB 115 4e-26 1A81-A nrPDB 115 5e-26 2FO0-A nrPDB 115 5e-26 6AMW-A nrPDB 115 6e-26 4XEY-B nrPDB 115 7e-26 1GRI-A nrPDB 113 2e-25 2H8H-A nrPDB 113 3e-25 3T04-A nrPDB 113 3e-25 6F3F-A nrPDB 112 3e-25 5U06-A nrPDB 112 6e-25 2AUG-A nrPDB 111 9e-25 2KK6-A nrPDB 110 2e-24 1NRV-A nrPDB 107 1e-23 4M4Z-A nrPDB 107 1e-23 2PLE-A nrPDB 106 3e-23 2LQW-A nrPDB 105 7e-23 2CRH-A nrPDB 101 8e-22 2LCT-A nrPDB 99 4e-21 2EKX-A nrPDB 95 5e-20 4XI2-A nrPDB 95 8e-20 3RO1-A nrPDB 86 5e-17 3F41-A nrPDB 80 2e-15 1MIL-A nrPDB 77 2e-14 Sequences not found previously or not previously below threshold: 2OZO-A nrPDB 104 1e-22 4XZ1-A nrPDB 104 1e-22 2EYZ-A nrPDB 84 1e-16 4E93-A nrPDB 82 8e-16 2CS0-A nrPDB 69 5e-12 2VIF-A nrPDB 69 7e-12 1RPY-A nrPDB 68 9e-12 1KA6-A nrPDB 68 1e-11 5M6U-B nrPDB 68 1e-11 2HDV-A nrPDB 68 1e-11 1M27-A nrPDB 67 1e-11 3CXL-A nrPDB 66 3e-11 1XA6-A nrPDB 64 1e-10 1G4W-R nrPDB 60 2e-09 6C5X-D nrPDB 60 3e-09 4ERC-A nrPDB 60 3e-09 4NX8-A nrPDB 58 1e-08 4JGH-A nrPDB 57 3e-08 3QWY-A nrPDB 57 3e-08 6C7Y-B nrPDB 57 3e-08 2BBU-A nrPDB 55 8e-08 4GL9-E nrPDB 54 1e-07 2HMH-A nrPDB 54 2e-07 5Z59-A nrPDB 51 1e-06 5XW4-A nrPDB 51 1e-06 3D1Q-A nrPDB 50 2e-06 3RZ2-A nrPDB 49 5e-06 1ZCK-A nrPDB 49 5e-06 5LXQ-B nrPDB 49 5e-06 5K23-A nrPDB 49 6e-06 5K22-A nrPDB 49 8e-06 2EL8-A nrPDB 47 3e-05 1FPZ-A nrPDB 47 3e-05 1OHC-A nrPDB 46 4e-05 3S4O-A nrPDB 46 5e-05 1XM2-A nrPDB 45 6e-05 1V3A-A nrPDB 45 6e-05 4TVV-A nrPDB 45 8e-05 3V0J-A nrPDB 44 1e-04 5BZX-A nrPDB 42 7e-04 2IZV-A nrPDB 42 8e-04 2RF6-A nrPDB 42 8e-04 3MAZ-A nrPDB 42 9e-04 1UUS-A nrPDB 42 0.001 2CR4-A nrPDB 42 0.001 2WGP-A nrPDB 40 0.002 2G6Z-A nrPDB 40 0.004 4R0S-A nrPDB 38 0.015 2M3V-A nrPDB 37 0.034 2OZ5-A nrPDB 36 0.056 3EZZ-A nrPDB 35 0.078 1YN9-A nrPDB 35 0.14 5IXI-A nrPDB 34 0.14 4YR8-G nrPDB 34 0.18 4ZYJ-A nrPDB 34 0.18 6D67-A nrPDB 33 0.25 2Q47-A nrPDB 33 0.34 2ESB-A nrPDB 33 0.35 6N8N-Y nrPDB 33 0.41 2J16-A nrPDB 32 0.56 4EVC-A nrPDB 32 0.62 1ZZW-A nrPDB 32 0.70 5GTJ-A nrPDB 32 0.70 3ZIF-N nrPDB 32 0.70 1M3G-A nrPDB 32 0.71 4B04-A nrPDB 32 0.72 2OUD-A nrPDB 32 0.72 4JMK-A nrPDB 32 0.82 6FEY-A nrPDB 32 0.86 4MBB-A nrPDB 32 1.0 3LJ8-A nrPDB 31 1.2 4NMN-A nrPDB 31 1.3 1YZ4-A nrPDB 31 1.4 5GQY-A nrPDB 31 1.9 1Z6T-A nrPDB 30 2.0 6E3B-A nrPDB 30 2.4 6I28-A nrPDB 30 2.8 1LW3-A nrPDB 30 3.2 1WRM-A nrPDB 30 3.9 4KYQ-A nrPDB 30 4.0 2G2B-A nrPDB 30 4.1 1I9T-A nrPDB 30 4.1 2C46-A nrPDB 29 5.2 4MHZ-A nrPDB 28 8.0 >3PS5-A nrPDB Length = 595 Score = 926 bits (2394), Expect = 0.0, Method: Composition-based stats. Identities = 594/595 (99%), Positives = 594/595 (99%) Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 Query: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120 Query: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG Sbjct: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180 Query: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA Sbjct: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240 Query: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD Sbjct: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300 Query: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK Sbjct: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360 Query: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH Sbjct: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420 Query: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVH SAGIGRTGTIIVIDMLMENISTKGLDC Sbjct: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHSSAGIGRTGTIIVIDMLMENISTKGLDC 480 Query: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT 540 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT Sbjct: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT 540 Query: 541 YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK 595 YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK Sbjct: 541 YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK 595 >2B3O-A nrPDB Length = 532 Score = 812 bits (2097), Expect = 0.0, Method: Composition-based stats. Identities = 532/532 (100%), Positives = 532/532 (100%) Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF Sbjct: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 Query: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA Sbjct: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 120 Query: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG Sbjct: 121 ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180 Query: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA Sbjct: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240 Query: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD Sbjct: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300 Query: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK Sbjct: 301 YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 360 Query: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH Sbjct: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH 420 Query: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC Sbjct: 421 GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480 Query: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ 532 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ Sbjct: 481 DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ 532 >4H1O-A nrPDB Length = 560 Score = 716 bits (1848), Expect = 0.0, Method: Composition-based stats. Identities = 312/532 (58%), Positives = 399/532 (75%), Gaps = 4/532 (0%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 RWFH +++G++AE LL RGV GSFLARPS+ N GDF+LSVR VTHI+IQN+G +YD Sbjct: 26 RWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGGYYD 85 Query: 63 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAET 122 LYGGEKFATL ELV+YY + G L++++G +I LKYPLNC+DPTSERW+HGH+SG +AE Sbjct: 86 LYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEK 145 Query: 123 LLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPK-AGPGSPLRVTHIKVMCEGGRYTVGGL 181 LL KG+ +FLVRES S PGDFVLSV + K +VTH+ + C+ +Y VGG Sbjct: 146 LLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGG 205 Query: 182 ETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAK 241 E FDSLTDLVEH+KK + E G + L+QP TR+NAA+IE+RV EL+K E+ D K Sbjct: 206 ERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVK 265 Query: 242 AGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDY 301 GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNILPFDH+RV+L D N P SDY Sbjct: 266 QGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDY 325 Query: 302 INANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGR 358 INAN I + N+K +YIA+QGCL+ TVNDFW+M +QENSRVIVMTT+EVE+G+ Sbjct: 326 INANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGK 385 Query: 359 NKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWP 418 +KCV YWP+ + YG V N E +Y LR L++S + G+ R +W Y + +WP Sbjct: 386 SKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWP 445 Query: 419 DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGL 478 DHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGIGRTGT IVID+L++ I KG+ Sbjct: 446 DHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGV 505 Query: 479 DCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQK 530 DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IET ++++E Q K Sbjct: 506 DCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSK 557 Score = 82.4 bits (202), Expect = 5e-16, Method: Composition-based stats. Identities = 41/112 (36%), Positives = 62/112 (55%), Gaps = 11/112 (9%) Query: 105 PTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRV 164 TS RW+H +++G +AE LL +G +FL R S S PGDF LSV + V Sbjct: 22 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGA---------V 72 Query: 165 THIKVMCEGGRYTVGGLETFDSLTDLVEHFKKT--GIEEASGAFVYLRQPYY 214 THIK+ GG Y + G E F +L +LV+++ + ++E +G + L+ P Sbjct: 73 THIKIQNTGGYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 124 >6CMQ-A nrPDB Length = 427 Score = 568 bits (1465), Expect = e-162, Method: Composition-based stats. Identities = 245/426 (57%), Positives = 314/426 (73%), Gaps = 4/426 (0%) Query: 102 CSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPK-AGPGS 160 DPTSERW+HGH+SG +AE LL KG+ +FLVRES S PGDFVLSV + K Sbjct: 2 SGDPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDG 61 Query: 161 PLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNA 220 +VTH+ + C+ +Y VGG E FDSLTDLVEH+KK + E G + L+QP TR+NA Sbjct: 62 KSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINA 121 Query: 221 ADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNIL 280 A+IE+RV EL+K E+ D K GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNIL Sbjct: 122 AEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNIL 181 Query: 281 PFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQ 337 PFDH+RV+L D N P SDYINAN I + N+K +YIA+QGCL+ TVNDFW+ Sbjct: 182 PFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWR 241 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQV 397 M +QENSRVIVMTT+EVE+G++KCV YWP+ + YG V N E +Y LR L++ Sbjct: 242 MVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKL 301 Query: 398 SPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGI 457 S + G+ R +W Y + +WPDHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGI Sbjct: 302 SKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGI 361 Query: 458 GRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE 517 GRTGT IVID+L++ I KG+DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IE Sbjct: 362 GRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE 421 Query: 518 TTKKKL 523 T ++++ Sbjct: 422 TLQRRI 427 Score = 125 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 52/117 (44%), Positives = 70/117 (59%), Gaps = 12/117 (10%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGD----------QVTHI 52 RWFH LSG +AE LL +G HGSFL R S+ + GDF LSVR GD +VTH+ Sbjct: 9 RWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHV 68 Query: 53 RIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSER 109 I+ YD+ GGE+F +LT+LVE+Y + V + GT++ LK PLN + + Sbjct: 69 MIRCQELKYDVGGGERFDSLTDLVEHYKKNPMV--ETLGTVLQLKQPLNTTRINAAE 123 >4HJQ-A nrPDB Length = 308 Score = 461 bits (1186), Expect = e-130, Method: Composition-based stats. Identities = 285/287 (99%), Positives = 286/287 (99%) Query: 242 AGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDY 301 +GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDY Sbjct: 22 SGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDY 81 Query: 302 INANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKC 361 INANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKC Sbjct: 82 INANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKC 141 Query: 362 VPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHG 421 VPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHG Sbjct: 142 VPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHG 201 Query: 422 VPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCD 481 VPSEPGGVLSFLDQINQRQESLPHAGPIIVH SAGIGRTGTIIVIDMLMENISTKGLDCD Sbjct: 202 VPSEPGGVLSFLDQINQRQESLPHAGPIIVHSSAGIGRTGTIIVIDMLMENISTKGLDCD 261 Query: 482 IDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQS 528 IDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQS Sbjct: 262 IDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQS 308 >4PVG-A nrPDB Length = 298 Score = 416 bits (1069), Expect = e-116, Method: Composition-based stats. Identities = 174/291 (59%), Positives = 222/291 (76%), Gaps = 3/291 (1%) Query: 237 EDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNI 296 D K GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNILPFDH+RV+L D N Sbjct: 2 TDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNE 61 Query: 297 PGSDYINANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQMAWQENSRVIVMTTRE 353 P SDYINAN I + N+K +YIA+QGCL+ TVNDFW+M +QENSRVIVMTT+E Sbjct: 62 PVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKE 121 Query: 354 VEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQ 413 VE+G++KCV YWP+ + YG V N E +Y LR L++S + G+ R +W Y Sbjct: 122 VERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYH 181 Query: 414 YLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENI 473 + +WPDHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGIGRTGT IVID+L++ I Sbjct: 182 FRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDII 241 Query: 474 STKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLE 524 KG+DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IET +++LE Sbjct: 242 REKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRLE 292 >2JJD-A nrPDB Length = 599 Score = 416 bits (1069), Expect = e-116, Method: Composition-based stats. Identities = 124/322 (38%), Positives = 170/322 (52%), Gaps = 17/322 (5%) Query: 222 DIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILP 281 I LE + S D K F EEF SL ++ + + EN+ KNRY NILP Sbjct: 9 PIPVEHLEEEIRIRSADDCKQ-FREEFNSLPSGHIQGTFEL--ANKEENREKNRYPNILP 65 Query: 282 FDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQ 341 DHSRVIL D IP SDYINA+YI + +IA+QG + TVNDFW+M W+ Sbjct: 66 NDHSRVILSQLDG-IPCSDYINASYIDGY-----KEKNKFIAAQGPKQETVNDFWRMVWE 119 Query: 342 ENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPL- 400 + S IVM T E+ KC YWP+ G YG V +Y +R + P Sbjct: 120 QKSATIVMLTNLKERKEEKCHQYWPDQGCW-TYGNIRVCVEDCVVLVDYTIRKFCIQPQL 178 Query: 401 -DNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGR 459 D R + + SWPD GVP P G+L FL ++ + HAGPI+VHCSAG+GR Sbjct: 179 PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTL--NPVHAGPIVVHCSAGVGR 236 Query: 460 TGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT 519 TGT IVID +M + + +D+ + + +R QR MVQT+ QY FIY A+ ++ Sbjct: 237 TGTFIVIDAMMAMMHAEQ---KVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYG 293 Query: 520 KKKLEVLQSQKGQESEYGNITY 541 +L+V +K ++ +G T+ Sbjct: 294 DTELDVSSLEKHLQTMHGTTTH 315 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 107/395 (27%), Positives = 179/395 (45%), Gaps = 38/395 (9%) Query: 147 LSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEE----- 201 + +L K +P+ I V C G G D++ ++ +K + E Sbjct: 206 IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI 265 Query: 202 ---------ASGAFVYLRQPYYA------TRVNAADIENRVLELNKKQESEDTAKAGFWE 246 + ++ Q T ++ + +E + ++ + K G E Sbjct: 266 RNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMH--GTTTHFDKIGLEE 323 Query: 247 EFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANY 306 EF L + + R G P N K R I+P+D +RVIL + +DYINA++ Sbjct: 324 EFRKLTNVRIMKENMRT-GNLPANMKKARVIQIIPYDFNRVILSMKRGQ-EYTDYINASF 381 Query: 307 IKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWP 366 I +IA+QG L TV DFW+M W+ S IVM T E+ ++KC YWP Sbjct: 382 IDGY-----RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWP 436 Query: 367 EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVS----PLDNGDLIREIWHYQYLSWPDHGV 422 G +G ++ + + +R V+ G+ +R + + + WP+ G+ Sbjct: 437 TEG-SVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQGEQVRVVRQFHFHGWPEIGI 495 Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482 P+E G++ + + Q+Q+ PI VHCSAG GRTGT I + ++E + +GL + Sbjct: 496 PAEGKGMIDLIAAV-QKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGL---L 551 Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE 517 D+ + ++ +R QR MVQT QY+F Y + FI+ Sbjct: 552 DVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 586 >2OOQ-A nrPDB Length = 286 Score = 400 bits (1029), Expect = e-112, Method: Composition-based stats. Identities = 122/297 (41%), Positives = 168/297 (56%), Gaps = 23/297 (7%) Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYK 277 + AD+ + ++ + Q GF EE+E+L + + + + EN+ KNRY Sbjct: 4 IRVADLLQHITQMKRGQG------YGFKEEYEALPEGQTASWD---TAKEDENRNKNRYG 54 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 NI+ +DHSRV L D + P SDYINANYI + YIA+QG ++ TV DFW+ Sbjct: 55 NIISYDHSRVRLLVLDGD-PHSDYINANYIDGY-----HRPRHYIATQGPMQETVKDFWR 108 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQV 397 M WQENS IVM T VE GR KCV YWP+ YG VT EY +RT V Sbjct: 109 MIWQENSASIVMVTNLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTV 166 Query: 398 SPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGI 457 + IRE+ + + SWPDHGVP G+L F+ Q+ + + P AGPI+VHCSAG Sbjct: 167 QKKGYHE-IRELRLFHFTSWPDHGVPCYATGLLGFVRQV--KFLNPPEAGPIVVHCSAGA 223 Query: 458 GRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514 GRTG I ID +++ +G+ +DI ++ +RAQR +VQTE QY F++ AI + Sbjct: 224 GRTGCFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 277 Score = 42.7 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 11/58 (18%), Positives = 19/58 (32%) Query: 145 FVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEA 202 + +L + +P I V C G G D++ D+ E+ I Sbjct: 193 YATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNC 250 >3I36-A nrPDB Length = 342 Score = 399 bits (1026), Expect = e-111, Method: Composition-based stats. Identities = 113/346 (32%), Positives = 176/346 (50%), Gaps = 22/346 (6%) Query: 195 KKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQ 254 K+ + +F + +P + + + E KKQ+++ + GF EE+E L+ Sbjct: 4 KRKDAKNNEVSFSQI-KPKKSKLIRVENFEAYF----KKQQAD--SNCGFAEEYEDLKLI 56 Query: 255 EVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGP 314 + + + EN+GKNRY N+LP+D SRV L + + DYINANY+ Sbjct: 57 GISL--PKYAAEIAENRGKNRYNNVLPYDISRVKLSVQTHST--DDYINANYMPGY---- 108 Query: 315 DENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAY 374 + K +IA+QG L T+ DFW+M W++N IVM T+ VE+GR KC YWP Q Y Sbjct: 109 -HSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVEQGRTKCEEYWPSKQAQD-Y 166 Query: 375 GPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLD 434 G +V E E+ +R V + + + + + + SWPDHGVP +++F Sbjct: 167 GDITVAMTSEVVLPEWTIRDFVVKNMQSSES-HPLRQFHFTSWPDHGVPDTTDLLINFRY 225 Query: 435 QINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQ 494 + + +P PI+VHCSAG+GRTGT I ID L+ I + +D+ + +R Sbjct: 226 LVRDYMKQIPPESPILVHCSAGVGRTGTFIAIDRLIYQIENEN---TVDVYGIVYDLRMH 282 Query: 495 RSGMVQTEAQYKFIYVAIAQFIETTK-KKLEVLQSQKGQESEYGNI 539 R MVQTE QY F+ + I K K++++ + Y N+ Sbjct: 283 RPLMVQTEDQYVFLNQCVLDIIRAQKDSKVDLIYQNTTAMTIYENL 328 >2C7S-A nrPDB Length = 313 Score = 399 bits (1026), Expect = e-111, Method: Composition-based stats. Identities = 122/326 (37%), Positives = 178/326 (54%), Gaps = 25/326 (7%) Query: 202 ASGAFVYLRQPYYATR--VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNL 259 +SG + Y+ + + AD+ + + + GF EE+ES + + + Sbjct: 8 SSGVDLGTENLYFQSMPAIRVADLLQHINLMK------TSDSYGFKEEYESFFEGQSASW 61 Query: 260 HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAK 319 ++ +N+ KNRY NI+ +DHSRVILQ + + P SDYINANYI + Sbjct: 62 D---VAKKDQNRAKNRYGNIIAYDHSRVILQPVE-DDPSSDYINANYIDGY-----QRPS 112 Query: 320 TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSV 379 YIA+QG + TV DFW+M WQE S IVM T VE GR KC YWP+ YG + V Sbjct: 113 HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTE--VYGDFKV 170 Query: 380 TNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQR 439 T EY +RT + + IRE+ + + WPDHGVP G+LSF+ ++ + Sbjct: 171 TCVEMEPLAEYVVRTFTLERRGYNE-IREVKQFHFTGWPDHGVPYHATGLLSFIRRV--K 227 Query: 440 QESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMV 499 + P AGPI+VHCSAG GRTG IVID++++ +G+ +DI ++ +R++R MV Sbjct: 228 LSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV---VDIYNCVKALRSRRINMV 284 Query: 500 QTEAQYKFIYVAIAQFIETTKKKLEV 525 QTE QY FI+ AI + + + V Sbjct: 285 QTEEQYIFIHDAILEACLCGETAIPV 310 >6D4D-A nrPDB Length = 292 Score = 392 bits (1008), Expect = e-109, Method: Composition-based stats. Identities = 119/300 (39%), Positives = 158/300 (52%), Gaps = 17/300 (5%) Query: 222 DIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILP 281 I LE + S D K F EEF SL ++ + + EN+ KNRY NILP Sbjct: 8 PIPVEHLEEEIRIRSADDCKQ-FREEFNSLPSGHIQGTFEL--ANKEENREKNRYPNILP 64 Query: 282 FDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQ 341 DHSRVIL D IP SDYINA+YI + +IA+QG + TVNDFW+M W+ Sbjct: 65 NDHSRVILSQLDG-IPCSDYINASYIDGY-----KEKNKFIAAQGPKQETVNDFWRMVWE 118 Query: 342 ENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPL- 400 + S IVM T E+ KC YWP+ G YG V +Y +R + P Sbjct: 119 QKSATIVMLTNLKERKEEKCHQYWPDQGCW-TYGNIRVCVEDCVVLVDYTIRKFCIQPQL 177 Query: 401 -DNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGR 459 D R + + SWPD GVP P G+L FL ++ + HAGPI+VHCSAG+GR Sbjct: 178 PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTL--NPVHAGPIVVHCSAGVGR 235 Query: 460 TGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT 519 TGT IVID +M + + +D+ + + +R QR MVQT+ QY FIY A+ ++ Sbjct: 236 TGTFIVIDAMMAMMHAEQ---KVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYG 292 Score = 53.5 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 12/83 (14%), Positives = 25/83 (30%), Gaps = 14/83 (16%) Query: 147 LSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEE----- 201 + +L K +P+ I V C G G D++ ++ +K + E Sbjct: 205 IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI 264 Query: 202 ---------ASGAFVYLRQPYYA 215 + ++ Q Sbjct: 265 RNQRPQMVQTDMQYTFIYQALLE 287 >1LAR-A nrPDB Length = 575 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 117/393 (29%), Positives = 192/393 (48%), Gaps = 34/393 (8%) Query: 144 DFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE--- 200 ++ +L+ + +PL + V C G G D++ + ++H K I Sbjct: 189 EYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHV 248 Query: 201 -----------EASGAFVYLRQPYYA------TRVNAADIENRVLELNKKQESEDTAKAG 243 + +V++ + T V A ++ + +L + E Sbjct: 249 TCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAME 308 Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303 EF+ L + + + + P NK KNR NI+P++ +RV LQ + GSDYIN Sbjct: 309 L--EFKLLASSKA-HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRG-VEGSDYIN 364 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 A+++ K YIA+QG L + DFW+M W+ NS +IVM T+ E GR KC Sbjct: 365 ASFLDGY-----RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQ 419 Query: 364 YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423 YWP R Y + V E++ +Y LR +V+ +G R I +Q+ WP+ GVP Sbjct: 420 YWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVTDARDGQS-RTIRQFQFTDWPEQGVP 477 Query: 424 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483 G + F+ Q+++ +E GPI VHCSAG+GRTG I + +++E + +G+ +D Sbjct: 478 KTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV---VD 534 Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 + +T++ +R QR MVQTE QY+ Y A +++ Sbjct: 535 MFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL 567 Score = 379 bits (974), Expect = e-105, Method: Composition-based stats. Identities = 108/292 (36%), Positives = 157/292 (53%), Gaps = 16/292 (5%) Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303 F +E+ES+ + NK KNRY N++ +DHSRVIL D +PGSDYIN Sbjct: 20 FSQEYESIDPGQQFTW---ENSNLEVNKPKNRYANVIAYDHSRVILTSIDG-VPGSDYIN 75 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 ANYI YIA+QG L T+ DFW+M W++ + +VM TR EK R KC Sbjct: 76 ANYIDGY-----RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ 130 Query: 364 YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423 YWP G + G VT + Y +RT + + + RE+ +Q+++WPDHGVP Sbjct: 131 YWPARGTETC-GLIQVTLLDTVELATYTVRTFALHKSGSSEK-RELRQFQFMAWPDHGVP 188 Query: 424 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483 P +L+FL ++ + AGP++VHCSAG+GRTG IVID ++E + + +D Sbjct: 189 EYPTPILAFLRRVKAC--NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEK---TVD 243 Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESE 535 I + +R+QR+ MVQTE QY FI+ A+ + ++ + Sbjct: 244 IYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKL 295 >2CFV-A nrPDB Length = 316 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 108/329 (32%), Positives = 168/329 (51%), Gaps = 23/329 (6%) Query: 202 ASGAFVYLRQPYYATR--VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNL 259 +SG + Y+ + + + E KKQ+++ + GF EE+E L+ + Sbjct: 8 SSGVDLGTENLYFQSMKLIRVENFEAYF----KKQQAD--SNCGFAEEYEDLKLVGIS-- 59 Query: 260 HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAK 319 + + EN+GKNRY N+LP+D SRV L + + DYINANY+ + K Sbjct: 60 QPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST--DDYINANYMPGY-----HSKK 112 Query: 320 TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSV 379 +IA+QG L T+ DFW+M W++N I+M T+ VE+GR KC YWP Q YG +V Sbjct: 113 DFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQD-YGDITV 171 Query: 380 TNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQR 439 E E+ +R V + + + + + S PDHGVP +++F + Sbjct: 172 AMTSEIVLPEWTIRDFTVKNIQTSES-HPLRQFHFTSAPDHGVPDTTDLLINFRYLVRDY 230 Query: 440 QESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMV 499 + P PI+VHCSAG+GRTGT I ID L+ I + +D+ + +R R MV Sbjct: 231 MKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENEN---TVDVYGIVYDLRMHRPLMV 287 Query: 500 QTEAQYKFIYVAIAQFIETTK-KKLEVLQ 527 QTE QY F+ + + + K K++++ Sbjct: 288 QTEDQYVFLNQCVLDIVRSQKDSKVDLIY 316 >1YFO-A nrPDB Length = 302 Score = 383 bits (983), Expect = e-106, Method: Composition-based stats. Identities = 114/307 (37%), Positives = 164/307 (53%), Gaps = 18/307 (5%) Query: 222 DIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILP 281 + LE + D K F EEF +L ++ + + ENK KNRY NILP Sbjct: 10 PLPVDKLEEEINRRMADDNKL-FREEFNALPACPIQATCE--AASKEENKEKNRYVNILP 66 Query: 282 FDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQ 341 +DHSRV L + +P SDYINA++I + +IA+QG E TVNDFW+M W+ Sbjct: 67 YDHSRVHLTPVEG-VPDSDYINASFINGY-----QEKNKFIAAQGPKEETVNDFWRMIWE 120 Query: 342 ENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLD 401 +N+ IVM T E+ KC YWP+ G YG V+ +Y +R + + Sbjct: 121 QNTATIVMVTNLKERKECKCAQYWPDQGCW-TYGNVRVSVEDVTVLVDYTVRKFCIQQVG 179 Query: 402 ---NGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIG 458 N R I + + SWPD GVP P G+L FL ++ + +AG I+VHCSAG+G Sbjct: 180 DVTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAC--NPQYAGAIVVHCSAGVG 237 Query: 459 RTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET 518 RTGT +VID +++ + ++ +D+ + +RAQR MVQT+ QY FIY A+ + Sbjct: 238 RTGTFVVIDAMLDMMHSE---RKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLY 294 Query: 519 TKKKLEV 525 +LEV Sbjct: 295 GDTELEV 301 Score = 48.9 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 13/83 (15%), Positives = 26/83 (31%), Gaps = 14/83 (16%) Query: 147 LSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE------ 200 + +L K +P I V C G G D++ D++ +K + Sbjct: 208 IGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHSERKVDVYGFVSRI 267 Query: 201 --------EASGAFVYLRQPYYA 215 + +V++ Q Sbjct: 268 RAQRCQMVQTDMQYVFIYQALLE 290 >1RPM-A nrPDB Length = 278 Score = 380 bits (977), Expect = e-106, Method: Composition-based stats. Identities = 114/297 (38%), Positives = 161/297 (54%), Gaps = 23/297 (7%) Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYK 277 + AD+ + ++ GF EE+ES + + ++ EN+ KNRY Sbjct: 2 IRVADLLQHITQMK------CAEGYGFKEEYESFFEGQSAPWDS---AKKDENRMKNRYG 52 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 NI+ +DHSRV LQ + + SDYIN NYI YIA+QG ++ T+ DFW+ Sbjct: 53 NIIAYDHSRVRLQTIEGD-TNSDYINGNYIDGY-----HRPNHYIATQGPMQETIYDFWR 106 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQV 397 M W EN+ I+M T VE GR KC YWP+ Y VT EY +RT V Sbjct: 107 MVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAV 164 Query: 398 SPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGI 457 + IREI + + WPDHGVP G+L F+ Q+ + S P AGP++VHCSAG Sbjct: 165 EKRGVHE-IREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSK--SPPSAGPLVVHCSAGA 221 Query: 458 GRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514 GRTG IVID++++ +G+ +DI ++ +R++R MVQTE QY FI+ AI + Sbjct: 222 GRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 275 >4BPC-A nrPDB Length = 582 Score = 380 bits (975), Expect = e-105, Method: Composition-based stats. Identities = 115/299 (38%), Positives = 163/299 (54%), Gaps = 30/299 (10%) Query: 225 NRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDH 284 N L+L+++ ES D + WE NK KNRY N++ +DH Sbjct: 22 NDSLKLSQEYESIDPGQQFTWE-----------------HSNLEVNKPKNRYANVIAYDH 64 Query: 285 SRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENS 344 SRVILQ + I GSDYINANY+ YIA+QG L T DFW+M W++ S Sbjct: 65 SRVILQPIEG-IMGSDYINANYVDGY-----RRQNAYIATQGPLPETFGDFWRMVWEQRS 118 Query: 345 RVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGD 404 IVM TR EK R KC YWP G + YG VT + + +RT + + + Sbjct: 119 ATIVMMTRLEEKSRIKCDQYWPNRGTE-TYGFIQVTLLDTIELATFAVRTFSLHKNGSSE 177 Query: 405 LIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTII 464 RE+ +Q+ +WPDHGVP P L+FL ++ + + P AGPI+VHCSAG+GRTG I Sbjct: 178 K-REVRQFQFTAWPDHGVPEYPTPFLAFLRRV--KTANPPDAGPIVVHCSAGVGRTGAFI 234 Query: 465 VIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKL 523 VID ++E I + +D+ + ++R+QR+ MVQTE QY FI+ A+ + + ++ Sbjct: 235 VIDAMLERIKPEK---TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGAGNTEV 290 Score = 374 bits (961), Expect = e-104, Method: Composition-based stats. Identities = 117/393 (29%), Positives = 191/393 (48%), Gaps = 34/393 (8%) Query: 144 DFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE--- 200 ++ L+ + +P I V C G G D++ + ++ K + Sbjct: 196 EYPTPFLAFLRRVKTANPPDAGPIVVHCSAGVGRTGAFIVIDAMLERIKPEKTVDVYGHV 255 Query: 201 -----------EASGAFVYLRQPYYA------TRVNAADIENRVLELNKKQESEDTAKAG 243 + + ++ + T V A + + +L + + E G Sbjct: 256 TLMRSQRNYMVQTEDQYSFIHEALLEAVGAGNTEVPARSLYAYIQKLAQVEPGEHVT--G 313 Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303 EF+ L + + + + P NK KNR NI+P++ +RV LQ + GSDYIN Sbjct: 314 MELEFKRLANSKA-HTSRFISANLPANKFKNRLVNIMPYESTRVALQPIRG-VEGSDYIN 371 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 A++I K YIA+QG L T DFW+M W+ NS ++VM T+ E GR KC Sbjct: 372 ASFIDGY-----RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ 426 Query: 364 YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423 YWP R Y + V E++ +Y LR +V+ +G R + +Q+ WP+ GVP Sbjct: 427 YWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVP 484 Query: 424 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483 G + F+ Q+++ +E GPI VHCSAG+GRTG I + +++E + +G+ +D Sbjct: 485 KSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VD 541 Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 I +T++M+R QR MVQTE +Y+F Y A +++ Sbjct: 542 IFQTVKMLRTQRPAMVQTEDEYQFAYQAALEYL 574 >2NLK-A nrPDB Length = 627 Score = 379 bits (974), Expect = e-105, Method: Composition-based stats. Identities = 114/317 (35%), Positives = 158/317 (49%), Gaps = 22/317 (6%) Query: 230 LNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVIL 289 + E + GF E+FE +Q+ PENK KNRY NIL +DHSRV L Sbjct: 9 VKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKL 68 Query: 290 QGRDS-NIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIV 348 + + SDYINANY+ AK YIA+QG L++T DFW+M W++N+ +IV Sbjct: 69 RPLPGKDSKHSDYINANYVDGY-----NKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIV 123 Query: 349 MTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPL-------- 400 M T VEKGR KC YWP + YG VT Y +R + Sbjct: 124 MITNLVEKGRRKCDQYWPTENSEE-YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKG 182 Query: 401 --DNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIG 458 R + Y Y WPD GVP VL+F+ +P GP++VHCSAG+G Sbjct: 183 NPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RSSAARMPETGPVLVHCSAGVG 240 Query: 459 RTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET 518 RTGT IVID +++ I K +++ ++ +R QR+ +VQTE QY FI+ A+ + I Sbjct: 241 RTGTYIVIDSMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG 297 Query: 519 TKKKLEVLQSQKGQESE 535 + ++ Q S Sbjct: 298 KETEVSSNQLHSYVNSI 314 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 81/405 (20%), Positives = 151/405 (37%), Gaps = 50/405 (12%) Query: 144 DFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGI---- 199 ++ L VL+ ++ + V C G G DS+ ++ + Sbjct: 208 EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFL 267 Query: 200 ----------EEASGAFVYLRQPY------YATRVNAADIENRVLELNKKQESEDTAKAG 243 + ++++ T V++ + + +N K Sbjct: 268 KHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHS---YVNSILIPGVGGKTR 324 Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303 ++F+ + + K + + Q+ NK KNR +++P + +RV L + G+DYIN Sbjct: 325 LEKQFKLVTQCNAKYV-ECFSAQKECNKEKNRNSSVVPSERARVGLAPL-PGMKGTDYIN 382 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMT---TREVEKGRNK 360 A+YI + +I +Q L T DFW+M W N+++IVM E Sbjct: 383 ASYIMGY-----YRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV- 436 Query: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTT-----EYKLRTLQVSPLDNGDLIREIWHYQYL 415 YWP ++VT + + + + D + E+ H+Q Sbjct: 437 ---YWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILE-ATQDDYVLEVRHFQCP 492 Query: 416 SWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENIST 475 WP+ P L + ++E+L GP IVH G G + + L + + Sbjct: 493 KWPNPDAPISSTFELINV----IKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLEN 548 Query: 476 KGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK 520 + + K I ++ R G+ QY+FIY A+ + T + Sbjct: 549 ENAVDVFQVAKMINLM---RPGVFTDIEQYQFIYKAMLSLVSTKE 590 >2NV5-A nrPDB Length = 299 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 109/305 (35%), Positives = 162/305 (53%), Gaps = 22/305 (7%) Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYK 277 + ++ + + L F +E+ES+ + NK KNRY Sbjct: 9 IPILELADHIERLKA------NDNLKFSQEYESIDPGQQFTW---EHSNLEVNKPKNRYA 59 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 N++ +DHSRV+L + IPGSDY+NANYI YIA+QG L T DFW+ Sbjct: 60 NVIAYDHSRVLLSAIEG-IPGSDYVNANYIDGY-----RKQNAYIATQGSLPETFGDFWR 113 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQV 397 M W++ S +VM T+ E+ R KC YWP G + +G VT + Y +RT + Sbjct: 114 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFAL 172 Query: 398 SPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGI 457 + + RE+ +Q+ +WPDHGVP P L+FL ++ + P AGP++VHCSAG+ Sbjct: 173 YKNGSSEK-REVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGV 229 Query: 458 GRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE 517 GRTG IVID ++E I + +DI + ++RAQR+ MVQTE QY FI+ A+ + + Sbjct: 230 GRTGCFIVIDAMLERIKHEK---TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT 286 Query: 518 TTKKK 522 + Sbjct: 287 CGNTE 291 Score = 53.1 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 10/81 (12%), Positives = 24/81 (29%), Gaps = 14/81 (17%) Query: 149 VLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE-------- 200 L+ + +P + V C G G D++ + ++H K I Sbjct: 203 FLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRA 262 Query: 201 ------EASGAFVYLRQPYYA 215 + ++++ Sbjct: 263 QRNYMVQTEDQYIFIHDALLE 283 >5AWX-A nrPDB Length = 298 Score = 372 bits (954), Expect = e-103, Method: Composition-based stats. Identities = 112/299 (37%), Positives = 160/299 (53%), Gaps = 19/299 (6%) Query: 233 KQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVIL-QG 291 K ++ A +GF EEFE +Q V P+NK KNRY NI+ +DHSRV L Q Sbjct: 11 KHVADLHASSGFTEEFEEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQL 70 Query: 292 RDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTT 351 + + +DYINANY+ K YIA+QG L++T DFW+M W+ N VIVM T Sbjct: 71 AEKDGKLTDYINANYVDGY-----NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT 125 Query: 352 REVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSP-------LDNGD 404 VEKGR KC YWP G + YG + VT Y +R + Sbjct: 126 NLVEKGRRKCDQYWPADGSEE-YGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRP 184 Query: 405 LIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTII 464 R + Y Y WPD GVP VL+F+ + + GP++VHCSAG+GRTGT I Sbjct: 185 SGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAV--GPVVVHCSAGVGRTGTYI 242 Query: 465 VIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKL 523 V+D +++ I +G ++I ++ +R+QR+ +VQTE QY FI+ + + I + + ++ Sbjct: 243 VLDSMLQQIQHEG---TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 298 Score = 45.4 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 32/94 (34%) Query: 144 DFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEAS 203 ++ L VL+ KA V + V C G G DS+ ++H I Sbjct: 204 EYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFL 263 Query: 204 GAFVYLRQPYYATRVNAADIENRVLELNKKQESE 237 R T I + ++E +E+E Sbjct: 264 KHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETE 297 >2PBN-A nrPDB Length = 313 Score = 371 bits (953), Expect = e-103, Method: Composition-based stats. Identities = 113/320 (35%), Positives = 161/320 (50%), Gaps = 25/320 (7%) Query: 215 ATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKN 274 + A ++ V + + + GF E+FE +Q+ PENK KN Sbjct: 5 PDDMEAIPVKQFVKHIGELYSNNQH---GFSEDFEEVQRCTADMNITAEHSNHPENKHKN 61 Query: 275 RYKNILPFDHSRVILQGRDS-NIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVN 333 RY NIL +DHSRV L+ + SDYINANY+ AK YIA+QG L++T Sbjct: 62 RYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGY-----NKAKAYIATQGPLKSTFE 116 Query: 334 DFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLR 393 DFW+M W++N+ +IVM T VEKGR KC YWP + YG VT Y +R Sbjct: 117 DFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE-YGNIIVTLKSTKIHACYTVR 175 Query: 394 TLQVSPL----------DNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESL 443 + R + Y Y WPD GVP VL+F+ + Sbjct: 176 RFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RSSAARM 233 Query: 444 PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEA 503 P GP++VHCSAG+GRTGT IVID +++ I K +++ ++ +R QR+ +VQTE Sbjct: 234 PETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEE 290 Query: 504 QYKFIYVAIAQFIETTKKKL 523 QY FI+ A+ + I + ++ Sbjct: 291 QYIFIHDALLEAILGKETEV 310 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 16/94 (17%), Positives = 30/94 (31%) Query: 144 DFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEAS 203 ++ L VL+ ++ + V C G G DS+ ++ + Sbjct: 216 EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFL 275 Query: 204 GAFVYLRQPYYATRVNAADIENRVLELNKKQESE 237 R T I + +LE +E+E Sbjct: 276 KHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE 309 >2H03-A nrPDB Length = 291 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 104/284 (36%), Positives = 149/284 (52%), Gaps = 16/284 (5%) Query: 239 TAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPG 298 + +E+E L+ +V PEN+GKNRY NILP+D +RV L G G Sbjct: 24 DSNYLLSKEYEELK--DVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSG------G 75 Query: 299 SDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGR 358 SDYINA+YI + + YI +QG L T +DFW+M W++N IVM T+ VEKGR Sbjct: 76 SDYINASYIPG-----NNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGR 130 Query: 359 NKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWP 418 KC YWP YG + E E+ +R ++ + D R I H+ Y WP Sbjct: 131 VKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWP 190 Query: 419 DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGL 478 DHGVP ++ F+ + P AGP +VHCSAG+GRTGT I +D +++ + +K Sbjct: 191 DHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSK-- 248 Query: 479 DCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKK 522 +DI + +R R MVQTE QY +++ + + K + Sbjct: 249 -DSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLR 291 >2PI7-A nrPDB Length = 312 Score = 368 bits (946), Expect = e-102, Method: Composition-based stats. Identities = 110/312 (35%), Positives = 165/312 (52%), Gaps = 24/312 (7%) Query: 231 NKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ 290 ++ + F +FE L+ + P N+ KNRY NILP+D SRV L Sbjct: 21 GYIKDMAKDSDYKFSLQFEELKL--IGLDIPHFAADLPMNRCKNRYTNILPYDFSRVRLV 78 Query: 291 GRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMT 350 + GSDYINANYI + + YIA+QG L T NDFW+M Q+ S++IVM Sbjct: 79 SMNEE-EGSDYINANYIPGY-----NSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 132 Query: 351 TREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIW 410 T+ EK R KC YWP AYG +V E + T++ R ++S D ++++ Sbjct: 133 TQCNEKRRVKCDHYWPFTEDPIAYGDITVEMLSEEEHTDWVYRNFRIS---YADEVQDVM 189 Query: 411 HYQYLSWPDHGVP--SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDM 468 H+ Y +WPDHGVP + +L F+ + Q+S+ GP+I+HCSAG+GRTGT I +D Sbjct: 190 HFNYTAWPDHGVPTANAAESILQFVQMVR--QKSVKSKGPMIIHCSAGVGRTGTFIALDW 247 Query: 469 LMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQS 528 L+++I +DI + +R+ R MVQTE QY FI+ + + K++ + Sbjct: 248 LLQHIRDHEF---VDILGLVSDMRSYRMSMVQTEEQYIFIHQCVQLMWQKKKQQFCIS-- 302 Query: 529 QKGQESEYGNIT 540 + Y N++ Sbjct: 303 ----DVIYENVS 310 >3S3F-A nrPDB Length = 307 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 103/277 (37%), Positives = 148/277 (53%), Gaps = 16/277 (5%) Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303 F EEFE L+ V P N+ KNR+ NILP+DHSR LQ D + GSDYIN Sbjct: 46 FSEEFEELK--HVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVD-DDEGSDYIN 102 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 ANY+ + + +I +QG L +T +DFW+M W+ NSR IVM TR EKGR KC Sbjct: 103 ANYVPGH-----NSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQ 157 Query: 364 YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423 YWP + YG V + ++ + + G R + H+ + +WPD GVP Sbjct: 158 YWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR---GSEQRILRHFHFTTWPDFGVP 214 Query: 424 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483 + P ++ F+ R + PI+VHCSAG+GR+GT I +D +++ I+T +D Sbjct: 215 NPPQTLVRFVRAFRDRIGAEQR--PIVVHCSAGVGRSGTFITLDRILQQINTSDY---VD 269 Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK 520 I + +R +R MVQTE QY I+ + +E + Sbjct: 270 IFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE 306 >2GJT-A nrPDB Length = 295 Score = 363 bits (933), Expect = e-101, Method: Composition-based stats. Identities = 104/297 (35%), Positives = 157/297 (52%), Gaps = 18/297 (6%) Query: 232 KKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQG 291 ++ + F +FE L+ + P N+ KNRY NILP+D SRV L Sbjct: 13 YIKDMAKDSDYKFSLQFEELKL--IGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVS 70 Query: 292 RDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTT 351 + G+DYINANYI + + YIA+QG L T NDFW+M Q+ S++IVM T Sbjct: 71 MNEE-EGADYINANYIPGY-----NSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 124 Query: 352 REVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWH 411 + EK R KC YWP AYG +V E + ++ R ++ + D ++++ H Sbjct: 125 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMH 181 Query: 412 YQYLSWPDHGVP--SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 469 + Y +WPDHGVP + +L F+ + Q++ GP+I+HCSAG+GRTGT I +D L Sbjct: 182 FNYTAWPDHGVPTANAAESILQFVHMVR--QQATKSKGPMIIHCSAGVGRTGTFIALDRL 239 Query: 470 MENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVL 526 +++I +DI + +R+ R MVQTE QY FI+ + K++ + Sbjct: 240 LQHIRDHEF---VDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCIS 293 >1YGU-A nrPDB Length = 610 Score = 361 bits (926), Expect = e-100, Method: Composition-based stats. Identities = 121/367 (32%), Positives = 188/367 (51%), Gaps = 21/367 (5%) Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYK 277 +N I +L K++ D + F EF+S+ + K E ++P N+ KNRY Sbjct: 5 MNVEPIHADILLETYKRKIADEGRP-FLAEFQSIPRVFSK--FPIKEARKPFNQNKNRYV 61 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 +ILP+D++RV L + + GS+YINA+YI + + YIA+QG + TV+DFW+ Sbjct: 62 DILPYDYNRVELSEINGDA-GSNYINASYIDGF-----KEPRKYIAAQGPRDETVDDFWR 115 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPE-VGMQRAYGPYSVTNCGEHDTTEYKLRTLQ 396 M W++ + VIVM TR E RNKC YWP RA+G V +Y ++ L Sbjct: 116 MIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLN 175 Query: 397 VSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAG 456 + RE+ H Q+ SWPDHGVP +P +L ++N S +GPI+VH SAG Sbjct: 176 IVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAF--SNFFSGPIVVHSSAG 233 Query: 457 IGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 +GRTGT I ID ++E + + +D+ + +R QR MVQ EAQY I+ A+ ++ Sbjct: 234 VGRTGTYIGIDAMLEGLEAEN---KVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYN 290 Query: 517 ETTKKKLEVLQSQKGQESEYGNITYPPAMKNA-HAKASRTSSKHKEDVYENLHTKNKREE 575 + + ++ + + + PP+ + A+ R S + H N+ E Sbjct: 291 QFGETEVNLSELHPYLHNMKKR--DPPSEPSPLEAEFQRLPSYRS---WRTQHIGNQEEN 345 Query: 576 KVKKQRS 582 K K + S Sbjct: 346 KSKNRNS 352 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 92/401 (22%), Positives = 166/401 (41%), Gaps = 61/401 (15%) Query: 165 THIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIE--------------EASGAFVYLR 210 I V G G D++ + +E K + + ++ + Sbjct: 224 GPIVVHSSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIH 283 Query: 211 QPYYA------TRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLE 264 Q T VN +++ + + K+ + + EF+ L ++ + Sbjct: 284 QALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSP--LEAEFQRLPSY--RSWRTQHI 339 Query: 265 GQRPENKGKNRYKNILPFDHSRVILQ------------------GRDSNIPGSDYINANY 306 G + ENK KNR N++P+D++RV L+ + S YINA++ Sbjct: 340 GNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASF 399 Query: 307 IKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWP 366 I + + IA+QG L+ T+ DFWQM +Q +VIVM T + C YW Sbjct: 400 IMSY-----WKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW- 453 Query: 367 EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEP 426 ++ YG V ++ Y LR ++ D R ++ YQY +W +P+EP Sbjct: 454 -GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS-RTVYQYQYTNWSVEQLPAEP 511 Query: 427 GGVLSFLDQINQR--QESLPH------AGPIIVHCSAGIGRTGTIIVIDMLMENISTKGL 478 ++S + + Q+ Q++ + P+++HC G +TG + + + + Sbjct: 512 KELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL---LNLLESAET 568 Query: 479 DCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT 519 + +DI + ++ +R R GMV T QY+F+Y IA Sbjct: 569 EEVVDIFQVVKALRKARLGMVSTFEQYQFLYDVIASTYPAQ 609 >2I75-A nrPDB Length = 320 Score = 357 bits (916), Expect = 8e-99, Method: Composition-based stats. Identities = 106/313 (33%), Positives = 162/313 (51%), Gaps = 15/313 (4%) Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYK 277 +++ ++ L + Q +E +F+ L +++ + P+N KNRY+ Sbjct: 21 LDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSC--AKLPQNISKNRYR 78 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 +I P+D +RVIL+G + DYINANYI ++ YIA QG L T DFWQ Sbjct: 79 DISPYDATRVILKGNE------DYINANYINMEI-PSSSIINQYIACQGPLPHTCTDFWQ 131 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQV 397 M W++ S ++VM T +VE+GR KC YWPE +YG Y VT E T Y R + + Sbjct: 132 MTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTL 191 Query: 398 SPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGI 457 + R + QY++WPDHGVP + L F+ + ++ P++VHCSAGI Sbjct: 192 FN-QEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG--KEEPVVVHCSAGI 248 Query: 458 GRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE 517 GRTG +I ++ M I +DI ++ +R QR+ M+QT +QY+F+ AI + E Sbjct: 249 GRTGVLITMETAMCLIECNQPVYPLDI---VRTMRDQRAMMIQTPSQYRFVCEAILKVYE 305 Query: 518 TTKKKLEVLQSQK 530 K + K Sbjct: 306 EGFVKPLTTSTNK 318 >3OLR-A nrPDB Length = 313 Score = 357 bits (916), Expect = 9e-99, Method: Composition-based stats. Identities = 106/307 (34%), Positives = 160/307 (52%), Gaps = 19/307 (6%) Query: 218 VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQ----EVKNLHQRLEGQRPENKGK 273 ++ +I + L+ +S+ K F EF L++Q + + ++P+N K Sbjct: 20 MDQREILQKFLDE---AQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKK 76 Query: 274 NRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVN 333 NRYK+ILP+D+SRV L S+ S YINAN+IK K YIA+QG L T+ Sbjct: 77 NRYKDILPYDYSRVELSLITSD-EDSSYINANFIKGVYG-----PKAYIATQGPLSTTLL 130 Query: 334 DFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM-QRAYGPYSVTNCGEHDTTEYKL 392 DFW+M W+ + +IVM E E G+ KC YW E G Q +GP+SV+ E ++Y + Sbjct: 131 DFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYII 190 Query: 393 RTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVH 452 RTL+V R I+ + Y +WPDH VPS +L + + QE + PI +H Sbjct: 191 RTLKVK---FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIH 245 Query: 453 CSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI 512 SAG GRTG I ID + + + + I+ +R QR +VQT+ QY+ +Y A+ Sbjct: 246 SSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAV 305 Query: 513 AQFIETT 519 + + Sbjct: 306 LELFKRQ 312 >4IKC-A nrPDB Length = 281 Score = 353 bits (906), Expect = 1e-97, Method: Composition-based stats. Identities = 92/274 (33%), Positives = 143/274 (52%), Gaps = 17/274 (6%) Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303 F EEF L K + P N+ KNR+ NI P++++RV L D+++PGSDYIN Sbjct: 24 FQEEFSELPK--FLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIA-DASVPGSDYIN 80 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 A+YI L +IA+QG L TV DFW+M W+ ++ +VM T+ EKGR +C Sbjct: 81 ASYISGYLC-----PNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQ 135 Query: 364 YWPEVGMQRA-YGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422 YWPE +G +T E ++ +R L++ + + + +WP+HGV Sbjct: 136 YWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCM---TVRQCNFTAWPEHGV 192 Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482 P ++ F+ + + P+IVH SAG+GRTG I +D L ++I+ + Sbjct: 193 PENSAPLIHFVKLVRASR--AHDTTPMIVHSSAGVGRTGVFIALDHLTQHINDHDF---V 247 Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 DI + +R++R MVQ AQY F++ I + Sbjct: 248 DIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 281 >4GFV-A nrPDB Length = 297 Score = 350 bits (897), Expect = 1e-96, Method: Composition-based stats. Identities = 106/305 (34%), Positives = 162/305 (53%), Gaps = 14/305 (4%) Query: 220 AADIENRVLE-LNKKQESEDTAKAGFWEEFESLQKQ-EVKNLHQRLEGQRPENKGKNRYK 277 AAD LE L + E AG + + ++ + + + G RPEN KNRYK Sbjct: 1 AADSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYK 60 Query: 278 NILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQ 337 ++LP+D +RVIL SDYIN N+I+ + + YIA+QG L T+ DFW+ Sbjct: 61 DVLPYDQTRVILSLLQEE-GHSDYINGNFIRGV-----DGSLAYIATQGPLPHTLLDFWR 114 Query: 338 MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKL-RTLQ 396 + W+ +VI+M RE+E GR +C YW + G + +T E E + RTL+ Sbjct: 115 LVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLK 174 Query: 397 VSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAG 456 V+ R ++ QY+SWPD GVPS P +L+ +++ + Q S P P+ VH SAG Sbjct: 175 VT---FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPE--PLCVHSSAG 229 Query: 457 IGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI 516 GRTG + +D + + + T+ + D + + +R QR VQTE QY+F+Y +AQ Sbjct: 230 CGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF 289 Query: 517 ETTKK 521 +T + Sbjct: 290 CSTLQ 294 >5HDE-A nrPDB Length = 307 Score = 349 bits (895), Expect = 2e-96, Method: Composition-based stats. Identities = 107/312 (34%), Positives = 160/312 (51%), Gaps = 16/312 (5%) Query: 215 ATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQK----QEVKNLHQRLEGQRPEN 270 A+ + + + + + + F +F L++ + ++ G++ EN Sbjct: 5 ASMEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEEN 64 Query: 271 KGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEA 330 KNRYK+ILPFDHSRV L + + SDYINAN+IK K Y+A+QG L Sbjct: 65 VKKNRYKDILPFDHSRVKLTLKTPS-QDSDYINANFIKGVYG-----PKAYVATQGPLAN 118 Query: 331 TVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM-QRAYGPYSVTNCGEHDTTE 389 TV DFW+M W+ N +IVM RE E GR KC YWP G + P+ ++ E T+ Sbjct: 119 TVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTD 178 Query: 390 YKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPI 449 Y +RTL + + R ++ + Y++WPDH VPS +L + + + QE PI Sbjct: 179 YFIRTLLLE---FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH--EDVPI 233 Query: 450 IVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIY 509 +HCSAG GRTG I ID + + + ++ IQ +R QR VQT+ QY+ ++ Sbjct: 234 CIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVH 293 Query: 510 VAIAQFIETTKK 521 AIAQ E + Sbjct: 294 RAIAQLFEKQLQ 305 >4BJO-A nrPDB Length = 338 Score = 345 bits (885), Expect = 4e-95, Method: Composition-based stats. Identities = 99/287 (34%), Positives = 153/287 (53%), Gaps = 15/287 (5%) Query: 231 NKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ 290 ++E E K+G W + E + + P+NK +NRY+++ PFDHSR+ L Sbjct: 19 EMEKEFEQIDKSGSWAAIYQDIRHEASD-FPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH 77 Query: 291 GRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMT 350 D+ DYINA+ IK + E ++YI +QG L T FW+M W++ SR +VM Sbjct: 78 QEDN-----DYINASLIKME-----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVML 127 Query: 351 TREVEKGRNKCVPYWPEVGMQR---AYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIR 407 R +EKG KC YWP+ + +T E + Y +R L++ L + R Sbjct: 128 NRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQE-TR 186 Query: 408 EIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVID 467 EI H+ Y +WPD GVP P L+FL ++ + P GP++VHCSAGIGR+GT + D Sbjct: 187 EILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLAD 246 Query: 468 MLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514 + + + +DI+K + +R R G++QT Q +F Y+A+ + Sbjct: 247 TCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE 293 Score = 29.6 bits (65), Expect = 4.4, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 30/79 (37%), Gaps = 5/79 (6%) Query: 133 FLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVE 192 F V ES P F L+ L ++G SP + V C G G D+ L++ Sbjct: 199 FGVPES---PASF-LNFLFKVRESGSLSP-EHGPVVVHCSAGIGRSGTFCLADTCLLLMD 253 Query: 193 HFKKTGIEEASGAFVYLRQ 211 K + + +R+ Sbjct: 254 KRKDPSSVDIKKVLLEMRK 272 >4RHG-A nrPDB Length = 306 Score = 342 bits (878), Expect = 2e-94, Method: Composition-based stats. Identities = 103/322 (31%), Positives = 163/322 (50%), Gaps = 23/322 (7%) Query: 202 ASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQ 261 +SG + Y+ + NA +E + +L K ES FE L +++ Sbjct: 8 SSGVDLGTENLYFQS--NADTLEGSMAQLKKGLESGTVLIQ-----FEQLYRKKPGL--A 58 Query: 262 RLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTY 321 + P+N KNRYK++LP+D +RV+LQG + DYINA+Y+ ++ Y Sbjct: 59 ITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE------DYINASYVNMEI-PAANLVNKY 111 Query: 322 IASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTN 381 IA+QG L T FWQ+ W + +IVM T E+GR KC YWP+ +G + + Sbjct: 112 IATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQC 171 Query: 382 CGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQE 441 E T Y R + V+ G+ + H QY++WP+HGVP + L F++ + + Sbjct: 172 QSEDCTIAYVSREMLVTNTQTGEE-HTVTHLQYVAWPEHGVPDDSSDFLEFVNYVRSLR- 229 Query: 442 SLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQT 501 + P++VH SAGIGRTG ++ ++ M +DI ++ +R QR+ MVQT Sbjct: 230 --VDSEPVLVHSSAGIGRTGVLVTMETAMCLTERNLPIYPLDI---VRKMRDQRAMMVQT 284 Query: 502 EAQYKFIYVAIAQFIETTKKKL 523 +QYKF+ AI + E ++ Sbjct: 285 SSQYKFVCEAILRVYEEGLVQM 306 >4GE6-A nrPDB Length = 314 Score = 337 bits (863), Expect = 1e-92, Method: Composition-based stats. Identities = 108/311 (34%), Positives = 161/311 (51%), Gaps = 30/311 (9%) Query: 219 NAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKN 278 +A I+ V +N +Q K G +EE+E ++++ P N KNRY + Sbjct: 9 HAMTIQELVDYVNARQ------KQGIYEEYEDIRRENPVGTFHCSMS--PGNLEKNRYGD 60 Query: 279 ILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQM 338 + D +RV L R + +DYINA+++ + YI +QG LE T DFW M Sbjct: 61 VPCLDQTRVKLTKRSGHTQ-TDYINASFMDGY-----KQKNAYIGTQGPLENTYRDFWLM 114 Query: 339 AWQENSRVIVMTTREVEKGRNKCVPYWP-EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQV 397 W++ VIVMTTR E GR KC YWP E + +G +VTN G + YK TL++ Sbjct: 115 VWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEI 174 Query: 398 SPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQ-----------ESLPHA 446 + R++ H+Q+LSWPD+GVPS ++ FL + +Q + Sbjct: 175 HNTEERQK-RQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPE 233 Query: 447 GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYK 506 PI+VHCSAGIGRTGT +D+ + + G +++ +T+ +R QR+ +QT QY Sbjct: 234 PPIVVHCSAGIGRTGTFCSLDICLAQLEELG---TLNVFQTVSRMRTQRAFSIQTPEQYY 290 Query: 507 FIYVAIAQFIE 517 F Y AI +F E Sbjct: 291 FCYKAILEFAE 301 >1P15-A nrPDB Length = 253 Score = 333 bits (853), Expect = 2e-91, Method: Composition-based stats. Identities = 89/255 (34%), Positives = 141/255 (55%), Gaps = 12/255 (4%) Query: 264 EGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIA 323 G P N KNR I+P++ +RVI+ + +DY+NA++I +YIA Sbjct: 3 TGNLPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFIDGY-----RQKDSYIA 56 Query: 324 SQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCG 383 SQG L T+ DFW+M W+ S IVM T E+G+ KC YWP G+ +YG +V Sbjct: 57 SQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGL-VSYGDITVELKK 115 Query: 384 EHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESL 443 E + Y +R L V+ R+I + + WP+ G+PS+ G+++ + + Q+Q+ Sbjct: 116 EEECESYTVRDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMINIIAAV-QKQQQQ 173 Query: 444 PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEA 503 PI VHCSAG GRTGT + ++E + +G+ +D+ +T++ +R QR MVQT Sbjct: 174 SGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLE 230 Query: 504 QYKFIYVAIAQFIET 518 QY+F Y + ++I+ Sbjct: 231 QYEFCYKVVQEYIDA 245 >1ZC0-A nrPDB Length = 309 Score = 332 bits (851), Expect = 2e-91, Method: Composition-based stats. Identities = 100/281 (35%), Positives = 145/281 (51%), Gaps = 18/281 (6%) Query: 235 ESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDS 294 + + + EEF + V P + K+RYK ILP SRV L GR Sbjct: 37 QRQPPSPKQLEEEFLKIPSNFVSPED----LDIPGHASKDRYKTILPNPQSRVCL-GRAQ 91 Query: 295 NIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREV 354 + DYINANYI+ D K YIA+QG + TV+DFW+M WQE +IVM T+ Sbjct: 92 SQEDGDYINANYIRGY----DGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLR 147 Query: 355 EKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQY 414 E G+ KCV YWP YGP+ + + EY +R L + + R + H + Sbjct: 148 E-GKEKCVHYWPTEEE--TYGPFQIRIQDMKECPEYTVRQLTI---QYQEERRSVKHILF 201 Query: 415 LSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENIS 474 +WPDH P G +L + ++ + E+ H GPI+VHCSAGIGRTG I + + + Sbjct: 202 SAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLK 261 Query: 475 TKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515 +G ++DI + +R R GM+QT QY+F++ +A + Sbjct: 262 ARG---EVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY 299 >2QEP-A nrPDB Length = 304 Score = 332 bits (850), Expect = 3e-91, Method: Composition-based stats. Identities = 104/313 (33%), Positives = 162/313 (51%), Gaps = 18/313 (5%) Query: 208 YLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQR 267 +P + ++ + + + ++++ + WE + Q + + QR Sbjct: 1 MSEEPV-QSNMDISTGHMILSYMEDHLKNKNRLEKE-WEALCAYQAEP----NSSFVAQR 54 Query: 268 PENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGC 327 EN KNR +L +DHSRV+L+ +S+ SDYINA+ I + D YIA+QG Sbjct: 55 EENVPKNRSLAVLTYDHSRVLLKAENSH-SHSDYINASPIMDH----DPRNPAYIATQGP 109 Query: 328 LEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDT 387 L ATV DFWQM W+ VIVM T E G +C YWP+ G Y Y V EH Sbjct: 110 LPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG-SNLYHIYEVNLVSEHIW 168 Query: 388 T-EYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA 446 ++ +R+ + L + R + + +LSW D GVPS +L F ++N+ + Sbjct: 169 CEDFLVRSFYLKNLQTNE-TRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRG--RS 225 Query: 447 GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYK 506 PIIVHCS G GR+GT ++IDM++ ++ +IDI T++ +R QR GMVQT+ Q++ Sbjct: 226 CPIIVHCSDGAGRSGTYVLIDMVLNKMAKG--AKEIDIAATLEHLRDQRPGMVQTKEQFE 283 Query: 507 FIYVAIAQFIETT 519 F A+A+ + Sbjct: 284 FALTAVAEEVNAI 296 >2BZL-A nrPDB Length = 325 Score = 330 bits (847), Expect = 8e-91, Method: Composition-based stats. Identities = 109/332 (32%), Positives = 176/332 (53%), Gaps = 29/332 (8%) Query: 202 ASGAFVYLRQPYYATRVNAA--DIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNL 259 +SG + Y+ + V+A ++ R L KK E + + E+E + K++ + Sbjct: 8 SSGVDLGTENLYFQSMVDATRVPMDERFRTLKKKLE-----EGMVFTEYEQIPKKKANGI 62 Query: 260 HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAK 319 PEN ++R + ++P++ +RV L N G YINA++IK + G + Sbjct: 63 FST--AALPENAERSRIREVVPYEENRVELIPTKENNTG--YINASHIKVVVGGAEW--- 115 Query: 320 TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQR---AYGP 376 YIA+QG L T +DFWQM W++ VI M T E E GR K YWP++G + YG Sbjct: 116 HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGK 175 Query: 377 YSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI 436 + VT D+ Y L+V L +G R +WH QY WPDHG P + G LS+L++I Sbjct: 176 FKVTTKFRTDSVCYATTGLKVKHLLSGQE-RTVWHLQYTDWPDHGCPEDVQGFLSYLEEI 234 Query: 437 NQRQESL--------PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTI 488 + PI+VHCSAG+GRTG +I+ ++++ + + +++ + Sbjct: 235 QSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEH---NEKVEVPMML 291 Query: 489 QMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK 520 +++R QR M+QT AQYKF+Y + QF++ ++ Sbjct: 292 RLLREQRMFMIQTIAQYKFVYQVLIQFLQNSR 323 Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 19/52 (36%) Query: 148 SVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGI 199 SV G+ R I V C G G L + + +EH +K + Sbjct: 236 SVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEV 287 >2A8B-A nrPDB Length = 283 Score = 329 bits (844), Expect = 2e-90, Method: Composition-based stats. Identities = 102/293 (34%), Positives = 149/293 (50%), Gaps = 18/293 (6%) Query: 223 IENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPF 282 I +R+L ++ ++ + EF + V E P + KNRYK ILP Sbjct: 1 IPSRILTRSQLRDVV-ASSHLLQSEFMEIPMNFVDP----KEIDIPRHGTKNRYKTILPN 55 Query: 283 DHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQE 342 SRV L+ ++ S YINANYI+ K +IA+QG + TV+DFWQM WQE Sbjct: 56 PLSRVCLRPKNVTDSLSTYINANYIRGY----SGKEKAFIATQGPMINTVDDFWQMVWQE 111 Query: 343 NSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDN 402 +S VIVM T+ EK KCV YWPE + YG V ++ Y +R L + Sbjct: 112 DSPVIVMITKLKEKN-EKCVLYWPEK--RGIYGKVEVLVISVNECDNYTIRNLVLK---Q 165 Query: 403 GDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGT 462 G + + HY Y SWPDH P +L + + + + + GP++VHCSAGIGRTG Sbjct: 166 GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGC 225 Query: 463 IIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515 I + + + +G+ +D + +R R GMVQT QY+F++ A+ + Sbjct: 226 FIATSIGCQQLKEEGV---VDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY 275 >1WCH-A nrPDB Length = 315 Score = 328 bits (840), Expect = 6e-90, Method: Composition-based stats. Identities = 113/285 (39%), Positives = 154/285 (54%), Gaps = 23/285 (8%) Query: 245 WEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINA 304 +E E+LQ E+K L Q L GQ EN+ KNRYKNILP+D +RV L YINA Sbjct: 52 SKELENLQ--ELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGG------YINA 103 Query: 305 NYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPY 364 ++IK + + YIA QG L TV DFWQM W++ S VI M T+EVE + KC Y Sbjct: 104 SFIKIPV---GKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRY 160 Query: 365 WPEV--GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGV 422 WP + + + +R + + + + +R I H + +WPDH Sbjct: 161 WPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE-VRHISHLNFTAWPDHDT 219 Query: 423 PSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482 PS+P +L+F+ + S GPII HCSAGIGR+GT+I ID+++ IS D D Sbjct: 220 PSQPDDLLTFISYMRHIHRS----GPIITHCSAGIGRSGTLICIDVVLGLISQ---DLDF 272 Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQ 527 DI ++ +R QR GMVQTE QY F Y I + T+ + E Q Sbjct: 273 DISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL--TRLQAEEEQ 315 >6D3F-A nrPDB Length = 279 Score = 327 bits (839), Expect = 8e-90, Method: Composition-based stats. Identities = 91/282 (32%), Positives = 142/282 (50%), Gaps = 16/282 (5%) Query: 240 AKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGS 299 G EEF L + + R G P N K R I+P+D +RVIL + + Sbjct: 1 GGGGLEEEFRKLTNVRIMKENMRT-GNLPANMKKARVIQIIPYDFNRVILSMKRGQ-EYT 58 Query: 300 DYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRN 359 DYINA++I +IA+QG L TV DFW+M W+ S IVM T E+ ++ Sbjct: 59 DYINASFIDGY-----RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQD 113 Query: 360 KCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVS----PLDNGDLIREIWHYQYL 415 KC YWP G +G ++ + + +R V+ + +R + + + Sbjct: 114 KCYQYWPTEG-SVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFH 172 Query: 416 SWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENIST 475 WP+ G+P+E G++ + + Q+Q+ PI VHCSAG GRTGT I + ++E + Sbjct: 173 GWPEIGIPAEGKGMIDLIAAV-QKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKA 231 Query: 476 KGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE 517 +GL +D+ + ++ +R QR MVQT QY+F Y + FI+ Sbjct: 232 EGL---LDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 270 >2I1Y-A nrPDB Length = 301 Score = 325 bits (832), Expect = 4e-89, Method: Composition-based stats. Identities = 99/280 (35%), Positives = 150/280 (53%), Gaps = 16/280 (5%) Query: 245 WEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINA 304 W+ + Q + + Q N KNR+ + LP+DH+R+ L+ +S+ SDYINA Sbjct: 35 WQALCAYQAEP----NTCATAQGEGNIKKNRHPDFLPYDHARIKLK-VESSPSRSDYINA 89 Query: 305 NYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPY 364 + I D YIA+QG L T+ DFWQM W+ VIVM T VE G +C Y Sbjct: 90 SPIIEH----DPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRY 145 Query: 365 WPEVGMQRAYGPYSVTNCGEHDTT-EYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423 WP+ G Y Y V EH ++ +R+ + + + R + + +LSWP G P Sbjct: 146 WPDEGAS-LYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQE-TRTLTQFHFLSWPAEGTP 203 Query: 424 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483 + +L F ++N+ + PIIVHCS G GRTGT I+IDM++ + KG+ +ID Sbjct: 204 ASTRPLLDFRRKVNKCYRG--RSCPIIVHCSDGAGRTGTYILIDMVLNRM-AKGVK-EID 259 Query: 484 IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKL 523 I T++ VR QR G+V+++ Q++F A+A+ + K L Sbjct: 260 IAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKAL 299 >1L8K-A nrPDB Length = 314 Score = 324 bits (831), Expect = 6e-89, Method: Composition-based stats. Identities = 95/281 (33%), Positives = 149/281 (53%), Gaps = 27/281 (9%) Query: 247 EFESLQKQE-----------VKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSN 295 EFE L Q + + + PEN+ +NRY+++ P+DHSRV LQ ++ Sbjct: 8 EFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAEN- 66 Query: 296 IPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVE 355 DYINA+ + +E ++YI +QG L T FW M WQ+ ++ +VM R VE Sbjct: 67 ----DYINASLVD-----IEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVE 117 Query: 356 KGRNKCVPYWPEVGMQRAYGP--YSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQ 413 K KC YWP + + +SV E + Y + LQ+ +++G+ R I H+ Sbjct: 118 KESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGE-TRTISHFH 176 Query: 414 YLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENI 473 Y +WPD GVP P L+FL ++ + P GP ++HCSAGIGR+GT ++D + + Sbjct: 177 YTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLM 236 Query: 474 STKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ 514 DI+I++ + +R R G++QT Q +F Y+AI + Sbjct: 237 EKG---DDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE 274 Score = 29.6 bits (65), Expect = 4.1, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 23/60 (38%), Gaps = 5/60 (8%) Query: 133 FLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVE 192 F V ES P F L+ L ++G +P + C G G D+ L+E Sbjct: 183 FGVPES---PASF-LNFLFKVRESGSLNP-DHGPAVIHCSAGIGRSGTFSLVDTCLVLME 237 >5OVR-A nrPDB Length = 305 Score = 323 bits (829), Expect = 1e-88, Method: Composition-based stats. Identities = 111/315 (35%), Positives = 156/315 (49%), Gaps = 26/315 (8%) Query: 202 ASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQ 261 +SG + Y+ + +RVL+ + E EF + V Sbjct: 8 SSGVDLGTENLYFQSM-------SRVLQAEELHEKALDP-FLLQAEFFEIPMNFVDP--- 56 Query: 262 RLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTY 321 E P KNRYK ILP HSRV L D + P S YINANYI+ K Y Sbjct: 57 -KEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGY----GGEEKVY 111 Query: 322 IASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTN 381 IA+QG + +TV DFW+M WQE++ +IVM T E KC YWPE Q AY +T Sbjct: 112 IATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEE--QVAYDGVEITV 168 Query: 382 CGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ-RQ 440 T +Y+LR + + +G R + HY + SWPD P +L + ++ + Q Sbjct: 169 QKVIHTEDYRLRLISLK---SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQ 225 Query: 441 ESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQ 500 + PH PIIVHCSAGIGRTG I + + + +G+ +DI KT +R R GM+Q Sbjct: 226 QEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV---VDILKTTCQLRQDRGGMIQ 282 Query: 501 TEAQYKFIYVAIAQF 515 T QY+F++ ++ + Sbjct: 283 TCEQYQFVHHVMSLY 297 >6H8S-A nrPDB Length = 301 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 103/273 (37%), Positives = 139/273 (50%), Gaps = 18/273 (6%) Query: 244 FWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYIN 303 EF + V E P KNRYK ILP HSRV L D P S YIN Sbjct: 38 LQAEFFEIPMNFVDP----KEYDIPGLVRKNRYKTILPNPHSRVRLTSPDPEDPLSSYIN 93 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 ANYI+ K YIA+QG + +TV DFW+M WQE + +IVM T E KC Sbjct: 94 ANYIRGY----SGEEKVYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEEMN-EKCTE 148 Query: 364 YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423 YWPE Q + +T T +Y+LR + + G R + HY + SWPD P Sbjct: 149 YWPEE--QVVHDGVEITVQKVIHTEDYRLRLISLRR---GTEERTLKHYWFTSWPDQKTP 203 Query: 424 SEPGGVLSFLDQINQ-RQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDI 482 +L + ++ + Q+ PH PIIVHCSAGIGRTG I + + + +G+ + Sbjct: 204 DRAPPLLHLVREVEEAAQQEGPHCSPIIVHCSAGIGRTGCFIATSICCQQLRREGV---V 260 Query: 483 DIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515 DI KT +R R GM+QT QY+F++ A++ + Sbjct: 261 DILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLY 293 >3M4U-A nrPDB Length = 306 Score = 268 bits (684), Expect = 7e-72, Method: Composition-based stats. Identities = 81/279 (29%), Positives = 123/279 (44%), Gaps = 26/279 (9%) Query: 247 EFESLQKQE-VKNLHQRLEGQRPENKGKNRYKNILPFDHSRV--ILQGRDSNIPGSDYIN 303 EF LQ+QE +N++ + N+ KNRY +IL + + +L+ + YIN Sbjct: 24 EFVQLQRQENPRNINFTTSLK---NRHKNRYLDILANEETIYPPVLKAVGAQPGRYPYIN 80 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 N I L T++A Q + V DF + ++ ++VM T+ E G K Sbjct: 81 GNLIDLDL------PHTFVACQAPVPQGVPDFLETLSEKKVDLVVMLTKLREGGVLKAER 134 Query: 364 YWPEVGMQRAYGP------YSVTNCGEHDTTEYKLRTLQVSPL---DNGDLIREIWHYQY 414 YWPE P VT E + PL G + + QY Sbjct: 135 YWPEEEEDSLSFPESGHDAIKVTRDAEASYEVDAELDIVRRPLVIHVPGKPMHRVLQVQY 194 Query: 415 LSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENIS 474 + WPDHGVP D++ ++ PI+VHCSAGIGRTGT+I + +I Sbjct: 195 VGWPDHGVPESAASF----DELLSVIKNCVTTSPILVHCSAGIGRTGTLIGAYAALLHIE 250 Query: 475 TKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIA 513 +G+ D + + ++ +R GMVQ QY IY+ + Sbjct: 251 -RGILTDSTVYSIVAAMKQKRFGMVQRLEQYAVIYMTVL 288 >4AZ1-A nrPDB Length = 302 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 80/283 (28%), Positives = 125/283 (44%), Gaps = 37/283 (13%) Query: 247 EFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD---YIN 303 EF L +QE + +N+ KNRY +IL + + L + ++ PG+ YIN Sbjct: 24 EFSLLLRQE--DPRSISFATSLKNRHKNRYLDILANEAT---LYPQVTDAPGASTPYYIN 78 Query: 304 ANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP 363 N I L ++A Q + + DF M +++ +++M T+ E G K Sbjct: 79 GNLIDLDL------PHKFVACQAPVVQGIPDFLAMLYEKKISLVIMVTKLEEGGFVKADR 132 Query: 364 YWPEVGMQRAYGPYSVT-----NCGEHDTTEY--------KLRTLQVSPLDNGDLIREIW 410 YWPE R G +V+ E Y R L + D + + Sbjct: 133 YWPEE---RGSGSIAVSGNCGLTISEDPGKAYEVEDELKITRRYLILQRAD--EPPHKFT 187 Query: 411 HYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLM 470 QY WPDHG+P + + L + ++ P P++VHCSAGIGRTGT+I + Sbjct: 188 QVQYTGWPDHGIPQSATSLEALLTNV----KNSPTTVPVVVHCSAGIGRTGTLIGAYAAL 243 Query: 471 ENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIA 513 ++ +G D + + +R QR GMVQ QY IY+ + Sbjct: 244 THLE-RGTLTDTTVYDVVSAMRRQRFGMVQRMEQYFVIYLTLM 285 >6DR7-A nrPDB Length = 306 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 60/257 (23%), Positives = 108/257 (42%), Gaps = 51/257 (19%) Query: 274 NRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVN 333 NR+++I Q R +D +NANYI+ N +T IA Q L++ + Sbjct: 65 NRFRDI----------QCRRQTAVRAD-LNANYIQV------GNTRT-IACQYPLQSQLE 106 Query: 334 DFWQMAWQENSRV--IVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTN-----CGEHD 386 ++M + + V ++ ++ E+ R Y+ + G YG +V + G D Sbjct: 107 SHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSG---TYGSITVESKMTQQVGLGD 163 Query: 387 TTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSE--PGGVLSFLDQINQRQESLP 444 + TL + + + H +WPD GVP + S +DQ + + ++ Sbjct: 164 GIMADMYTLTIREAGQKTISVPVVHV--TTWPDFGVPESEVTKALASLVDQTAETKRNMY 221 Query: 445 HAG------------PIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVR 492 + P+I HC AG+GRT +I M M + + + ++ + +R Sbjct: 222 ESKGSSAVADDSKLRPVI-HCRAGVGRTAQLIGA-MCMND----SRNSQLSVEDMVSQMR 275 Query: 493 AQRSG-MVQTEAQYKFI 508 QR+G MVQ + Q + Sbjct: 276 VQRNGIMVQKDEQLDVL 292 >1AD5-A nrPDB Length = 438 Score = 131 bits (330), Expect = 8e-31, Method: Composition-based stats. Identities = 39/151 (25%), Positives = 65/151 (43%), Gaps = 12/151 (7%) Query: 99 PLNCS----DPTSERWYHGHMSGGQAETLLQAKGEP-WTFLVRESLSQPGDFVLSVLSDQ 153 P N +E W+ +S AE L A G +F++R+S + G + LSV Sbjct: 51 PSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYD 110 Query: 154 PKAGPGSPLRVTHIKVMC-EGGRYTVGGLETFDSLTDLVEHFKK--TGIEEASGAFVYLR 210 P+ G V H K+ + G + + TF +L +LV+H+KK G+ + Sbjct: 111 PRQGD----TVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSS 166 Query: 211 QPYYATRVNAADIENRVLELNKKQESEDTAK 241 +P +A +I L+L KK + + Sbjct: 167 KPQKPWEKDAWEIPRESLKLEKKLGAGQFGE 197 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 38/114 (33%), Positives = 53/114 (46%), Gaps = 14/114 (12%) Query: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSV-----RVGDQVTHIRIQN- 56 WF + +S DAE L G + GSF+ R S +G +SLSV R GD V H +I+ Sbjct: 66 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 125 Query: 57 SGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERW 110 + + F+TL ELV++Y + DG L P S P + W Sbjct: 126 DNGGFYISPRSTFSTLQELVDHYK------KGNDGLCQKLSVPCMSSKPQ-KPW 172 >1K9A-A nrPDB Length = 450 Score = 125 bits (314), Expect = 6e-29, Method: Composition-based stats. Identities = 32/100 (32%), Positives = 42/100 (42%), Gaps = 7/100 (7%) Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 ++ WFH ++ AE LL G FL R S GD++L V +V H RI Sbjct: 79 LMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASK 137 Query: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPL 100 + F L +LVE+YT D DG L P Sbjct: 138 LSIDEEVYFENLMQLVEHYT------TDADGLCTRLIKPK 171 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 14/110 (12%) Query: 103 SDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPL 162 + + W+HG ++ QAE LL E FLVRES + PGD+ L V + Sbjct: 75 TKLSLMPWFHGKITREQAERLLY-PPETGLFLVRESTNYPGDYTLCVSCEG--------- 124 Query: 163 RVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 +V H ++M + ++ F++L LVEH+ +A G L +P Sbjct: 125 KVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTT----DADGLCTRLIKP 170 >2EOB-A nrPDB Length = 124 Score = 118 bits (297), Expect = 5e-27, Method: Composition-based stats. Identities = 34/115 (29%), Positives = 51/115 (44%), Gaps = 10/115 (8%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 W++ LS +AE +L G+FL R R+ ++++ R +V H RI G + Sbjct: 20 PWYYDRLSRGEAEDMLMRIPRDGAFLIR-KREGTDSYAITFRARGKVKHCRINRDGRHFV 78 Query: 63 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSG 117 L F +L ELV YY + + R L+YP+ P Y G SG Sbjct: 79 LGTSAYFESLVELVSYYEKHALYRKMR------LRYPVT---PELLERYSGPSSG 124 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 26/118 (22%), Positives = 52/118 (44%), Gaps = 15/118 (12%) Query: 99 PLNCSDPT-SERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAG 157 P+ +P S+ WY+ +S G+AE +L FL+R+ + ++ + Sbjct: 9 PVPNPNPHESKPWYYDRLSRGEAEDMLMRIPRDGAFLIRKREGT-DSYAITFRARG---- 63 Query: 158 PGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYA 215 +V H ++ +G + +G F+SL +LV +++K + + LR P Sbjct: 64 -----KVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRK----MRLRYPVTP 112 >4FL3-A nrPDB Length = 635 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 57/264 (21%), Positives = 96/264 (36%), Gaps = 73/264 (27%) Query: 2 VRWFHRDLSGLDAETLLKGRGV-HGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNS-GD 59 + +F +++ +AE L G+ G +L R SR G F+LSV G + H I+ Sbjct: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 Query: 60 FYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN------------------ 101 Y + GG A+ +L Y++Q + DG + LK P N Sbjct: 73 TYAIAGGRTHASPADLCHYHSQ------ESDGLVCLLKKPFNRPQGVQPKTGPFEDLKEN 126 Query: 102 ----------------------CSDPTSE-----------RWYHGHMSGGQAETL-LQAK 127 P E W+HG +S ++E + L Sbjct: 127 LIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGS 186 Query: 128 GEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCE-GGRYTVGGLETFDS 186 FL+R + G + L +L + +V H ++ + G+ ++ + FD+ Sbjct: 187 KTNGKFLIRARDNN-GSYALCLLHEG---------KVLHYRIDKDKTGKLSIPEGKKFDT 236 Query: 187 LTDLVEH--FKKTGIEEASGAFVY 208 L LVEH +K G+ Sbjct: 237 LWQLVEHYSYKADGLLRVLTVPCQ 260 Score = 105 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 44/177 (24%), Positives = 68/177 (38%), Gaps = 30/177 (16%) Query: 2 VRWFHRDLSGLDAETL-LKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGD 59 + WFH +S ++E + L G +G FL R +R N G ++L + +V H RI ++ Sbjct: 166 MPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTG 224 Query: 60 FYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSD-------------PT 106 + G+KF TL +LVE+Y+ DG + L P P Sbjct: 225 KLSIPEGKKFDTLWQLVEHYSY------KADGLLRVLTVPCQKIGTQGNVNFGGRPQLPG 278 Query: 107 SER--WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSP 161 S W G + G R+S G+ S +S P +P Sbjct: 279 SHPATWSAGGIISRIKSYSFPKPGH------RKSSPAQGNRQESTVSFNPYEPELAP 329 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 33/173 (19%), Positives = 64/173 (36%), Gaps = 22/173 (12%) Query: 109 RWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHI 167 ++ G+++ +AE L G +L+R+S + G F LSV + H Sbjct: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV---------AHGRKAHHY 64 Query: 168 KVMCE-GGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYY------ATRVNA 220 + E G Y + G T S DL + + E+ G L++P+ Sbjct: 65 TIERELNGTYAIAGGRTHASPADLCHYHSQ----ESDGLVCLLKKPFNRPQGVQPKTGPF 120 Query: 221 ADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGK 273 D++ ++ +++ + + S + Q K + + P GK Sbjct: 121 EDLKENLIR-EYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGK 172 >2ABL-A nrPDB Length = 163 Score = 115 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 72 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 130 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 131 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 161 Score = 106 bits (265), Expect = 3e-23, Method: Composition-based stats. Identities = 37/115 (32%), Positives = 51/115 (44%), Gaps = 17/115 (14%) Query: 99 PLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGP 158 P+N + S WYHG +S AE LL + G +FLVRES S PG +S+ + Sbjct: 63 PVNSLEKHS--WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG----- 114 Query: 159 GSPLRVTHIKVM-CEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 RV H ++ G+ V F++L +LV H A G L P Sbjct: 115 ----RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTV----ADGLITTLHYP 161 >1A81-A nrPDB Length = 254 Score = 115 bits (288), Expect = 5e-26, Method: Composition-based stats. Identities = 57/264 (21%), Positives = 96/264 (36%), Gaps = 73/264 (27%) Query: 2 VRWFHRDLSGLDAETLLKGRGV-HGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNS-GD 59 + +F +++ +AE L G+ G +L R SR G F+LSV G + H I+ Sbjct: 5 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 64 Query: 60 FYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN------------------ 101 Y + GG A+ +L Y++Q + DG + LK P N Sbjct: 65 TYAIAGGRTHASPADLCHYHSQ------ESDGLVCLLKKPFNRPQGVQPKTGPFEDLKEN 118 Query: 102 ----------------------CSDPTSE-----------RWYHGHMSGGQAETL-LQAK 127 P E W+HG +S ++E + L Sbjct: 119 LIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGS 178 Query: 128 GEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCE-GGRYTVGGLETFDS 186 FL+R + G + L +L + +V H ++ + G+ ++ + FD+ Sbjct: 179 KTNGKFLIRARDNN-GSYALCLLHEG---------KVLHYRIDKDKTGKLSIPEGKKFDT 228 Query: 187 LTDLVEH--FKKTGIEEASGAFVY 208 L LVEH +K G+ Sbjct: 229 LWQLVEHYSYKADGLLRVLTVPCQ 252 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 33/173 (19%), Positives = 64/173 (36%), Gaps = 22/173 (12%) Query: 109 RWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHI 167 ++ G+++ +AE L G +L+R+S + G F LSV + H Sbjct: 6 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV---------AHGRKAHHY 56 Query: 168 KVMCE-GGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYY------ATRVNA 220 + E G Y + G T S DL + + E+ G L++P+ Sbjct: 57 TIERELNGTYAIAGGRTHASPADLCHYHSQ----ESDGLVCLLKKPFNRPQGVQPKTGPF 112 Query: 221 ADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGK 273 D++ ++ +++ + + S + Q K + + P GK Sbjct: 113 EDLKENLIR-EYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGK 164 >2FO0-A nrPDB Length = 495 Score = 115 bits (288), Expect = 5e-26, Method: Composition-based stats. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 104 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 162 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 163 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 193 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 42/166 (25%), Positives = 62/166 (37%), Gaps = 35/166 (21%) Query: 99 PLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGP 158 P+N + S WYHG +S AE LL + G +FLVRES S PG +S+ + Sbjct: 95 PVNSLEKHS--WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG----- 146 Query: 159 GSPLRVTHIKVM-CEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP----- 212 RV H ++ G+ V F++L +LV H A G L P Sbjct: 147 ----RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTV----ADGLITTLHYPAPKRN 198 Query: 213 ----------YYATRVNAADIENRVLELNKKQESEDTAKAGFWEEF 248 Y + DI ++ G W+++ Sbjct: 199 KPTVYGVSPNYDKWEMERTDI---TMKHKLGGGQYGEVYEGVWKKY 241 >6AMW-A nrPDB Length = 255 Score = 115 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 146 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 204 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 205 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 235 Score = 105 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 37/115 (32%), Positives = 51/115 (44%), Gaps = 17/115 (14%) Query: 99 PLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGP 158 P+N + S WYHG +S AE LL + G +FLVRES S PG +S+ + Sbjct: 137 PVNSLEKHS--WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG----- 188 Query: 159 GSPLRVTHIKVM-CEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 RV H ++ G+ V F++L +LV H A G L P Sbjct: 189 ----RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTV----ADGLITTLHYP 235 >4XEY-B nrPDB Length = 408 Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 12 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 70 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 71 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 101 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 41/165 (24%), Positives = 61/165 (36%), Gaps = 35/165 (21%) Query: 100 LNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPG 159 +N + S WYHG +S AE LL + G +FLVRES S PG +S+ + Sbjct: 4 VNSLEKHS--WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG------ 54 Query: 160 SPLRVTHIKVM-CEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP------ 212 RV H ++ G+ V F++L +LV H A G L P Sbjct: 55 ---RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTV----ADGLITTLHYPAPKRNK 107 Query: 213 ---------YYATRVNAADIENRVLELNKKQESEDTAKAGFWEEF 248 Y + DI ++ G W+++ Sbjct: 108 PTVYGVSPNYDKWEMERTDI---TMKHKLGGGQYGEVYEGVWKKY 149 >1GRI-A nrPDB Length = 217 Score = 113 bits (284), Expect = 2e-25, Method: Composition-based stats. Identities = 28/87 (32%), Positives = 40/87 (45%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 WF + AE +L + G+FL R S GDFSLSV+ G+ V H ++ G Sbjct: 59 PWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKY 118 Query: 63 LYGGEKFATLTELVEYYTQQQGVLQDR 89 KF +L ELV+Y+ + Sbjct: 119 FLWVVKFNSLNELVDYHRSTSVSRNQQ 145 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 42/141 (29%), Positives = 65/141 (46%), Gaps = 18/141 (12%) Query: 83 QGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQP 142 + L +DG I P N + W+ G + +AE +L + FL+RES S P Sbjct: 38 KAELNGKDGFI-----PKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAP 92 Query: 143 GDFVLSVLSDQPKAGPGSPLRVTHIKVMCEG-GRYTVGGLETFDSLTDLVEHFKKTGIEE 201 GDF LSV V H KV+ +G G+Y + ++ F+SL +LV++ + T + Sbjct: 93 GDFSLSVKFGN---------DVQHFKVLRDGAGKYFLWVVK-FNSLNELVDYHRSTSVSR 142 Query: 202 ASGAFVYLRQ--PYYATRVNA 220 F+ + P T V A Sbjct: 143 NQQIFLRDIEQVPQQPTYVQA 163 >2H8H-A nrPDB Length = 535 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 46/182 (25%), Positives = 70/182 (38%), Gaps = 15/182 (8%) Query: 99 PLNCSDPT----SERWYHGHMSGGQAETLL-QAKGEPWTFLVRESLSQPGDFVLSVLSDQ 153 P N P+ +E WY G ++ ++E LL A+ TFLVRES + G + LSV Sbjct: 135 PSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFD 194 Query: 154 PKAGPGSPLRVTHIKVM-CEGGRYTVGGLETFDSLTDLVEHFKK--TGIEEASGAFVYLR 210 G L V H K+ + G + + F+SL LV ++ K G+ Sbjct: 195 NAKG----LNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTS 250 Query: 211 QPYYA-TRVNAADIENRV--LELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQR 267 +P +A +I LE+ Q G W + + +K E Sbjct: 251 KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFL 310 Query: 268 PE 269 E Sbjct: 311 QE 312 Score = 90.1 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 13/113 (11%) Query: 4 WFHRDLSGLDAETLLKG-RGVHGSFLARPSRKNQGDFSLSVR-----VGDQVTHIRIQN- 56 W+ ++ ++E LL G+FL R S +G + LSV G V H +I+ Sbjct: 150 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 209 Query: 57 SGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSER 109 + + +F +L +LV YY++ DG L S P ++ Sbjct: 210 DSGGFYITSRTQFNSLQQLVAYYSKHA------DGLCHRLTTVCPTSKPQTQG 256 >3T04-A nrPDB Length = 123 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 36/97 (37%), Positives = 49/97 (50%), Gaps = 8/97 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H +S AE LL G++GSFL R S + G S+S+R +V H RI + D Sbjct: 18 WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 76 Query: 64 YGGE-KFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 E +F TL ELV +++ DG I L YP Sbjct: 77 VSSESRFNTLAELVHHHSTVA------DGLITTLHYP 107 Score = 103 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 37/115 (32%), Positives = 51/115 (44%), Gaps = 17/115 (14%) Query: 99 PLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGP 158 P+N + S WYHG +S AE LL + G +FLVRES S PG +S+ + Sbjct: 9 PVNSLEKHS--WYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEG----- 60 Query: 159 GSPLRVTHIKVM-CEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 RV H ++ G+ V F++L +LV H A G L P Sbjct: 61 ----RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTV----ADGLITTLHYP 107 >6F3F-A nrPDB Length = 455 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 54/224 (24%), Positives = 85/224 (37%), Gaps = 33/224 (14%) Query: 99 PLNCSDPT----SERWYHGHMSGGQAETLL-QAKGEPWTFLVRESLSQPGDFVLSVLSDQ 153 P N P+ +E WY G ++ ++E LL A+ TFLVRES + G + LSV Sbjct: 55 PSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFD 114 Query: 154 PKAGPGSPLRVTHIKVM-CEGGRYTVGGLETFDSLTDLVEHFKK--TGIEEASGAFVYLR 210 G L V H K+ + G + + F+SL LV ++ K G+ Sbjct: 115 NAKG----LNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTS 170 Query: 211 QPYYAT-RVNAADIENRV--LELNKKQESEDTAKAGFWE-----EFESLQKQEVKNLHQR 262 +P +A +I LE+ Q G W ++L+ + Sbjct: 171 KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFL 230 Query: 263 LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIP---GSDYIN 303 E Q K R++ + V L S P ++Y+N Sbjct: 231 QEAQV---MKKLRHEKL-------VQLYAVVSEEPIYIVTEYMN 264 Score = 89.7 bits (221), Expect = 4e-18, Method: Composition-based stats. Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 13/113 (11%) Query: 4 WFHRDLSGLDAETLLKG-RGVHGSFLARPSRKNQGDFSLSVR-----VGDQVTHIRIQN- 56 W+ ++ ++E LL G+FL R S +G + LSV G V H +I+ Sbjct: 70 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 129 Query: 57 SGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSER 109 + + +F +L +LV YY++ DG L S P ++ Sbjct: 130 DSGGFYITSRTQFNSLQQLVAYYSKHA------DGLCHRLTTVCPTSKPQTQG 176 >5U06-A nrPDB Length = 120 Score = 112 bits (279), Expect = 6e-25, Method: Composition-based stats. Identities = 30/89 (33%), Positives = 47/89 (52%), Gaps = 6/89 (6%) Query: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 WFH +S +++ L+ +G V G FL R S++N F LS+ +V H I S + Sbjct: 19 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 78 Query: 63 LY-----GGEKFATLTELVEYYTQQQGVL 86 LY G +F L +LVE++ +G+L Sbjct: 79 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 107 Score = 65.5 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 25/97 (25%), Positives = 40/97 (41%), Gaps = 15/97 (15%) Query: 107 SERWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 ++ W+HG +S +++ L+ +G FLVRES P FVLS+ +V Sbjct: 16 TQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSL---------CHLQKVK 66 Query: 166 HIKVMCEGGRYTV-----GGLETFDSLTDLVEHFKKT 197 H ++ + G F L LVE + Sbjct: 67 HYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLN 103 >2AUG-A nrPDB Length = 126 Score = 111 bits (278), Expect = 9e-25, Method: Composition-based stats. Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 6/90 (6%) Query: 3 RWFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI---QNSG 58 WFH +S +A+ L+ +G V G FL R S+ N F LS+ G ++ H +I ++ G Sbjct: 27 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 86 Query: 59 DFYDL--YGGEKFATLTELVEYYTQQQGVL 86 + + G +F L +LVE+Y +GVL Sbjct: 87 EMFHTLDDGHTRFTDLIQLVEFYQLNKGVL 116 Score = 58.5 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 15/97 (15%) Query: 107 SERWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 S+ W+H +S +A+ L+ +G FLVR+S S P FVLS+ Q ++ Sbjct: 25 SQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQ---------KIK 75 Query: 166 HIKV--MCEGGRYTVG---GLETFDSLTDLVEHFKKT 197 H ++ + + G G F L LVE ++ Sbjct: 76 HFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLN 112 >2KK6-A nrPDB Length = 116 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 26/98 (26%), Positives = 49/98 (50%), Gaps = 4/98 (4%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H + ++A+ LLK + G FL R S G++ LSV Q H IQ + Y Sbjct: 19 WYHGAIPRIEAQELLKKQ---GDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYR- 74 Query: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 + G F+ + +L++++ + V+ + G ++ P + Sbjct: 75 FEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKD 112 Score = 75.1 bits (183), Expect = 8e-14, Method: Composition-based stats. Identities = 34/108 (31%), Positives = 53/108 (49%), Gaps = 16/108 (14%) Query: 103 SDPTSER-WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSP 161 P +E+ WYHG + +A+ LL+ +G+ FLVRES +PG++VLSV SD + Sbjct: 11 MKPLAEQDWYHGAIPRIEAQELLKKQGD---FLVRESHGKPGEYVLSVYSDGQR------ 61 Query: 162 LRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHF--KKTGIEEASGAFV 207 H + Y G F ++ L++H K I + SG + Sbjct: 62 ---RHFIIQYVDNMYRFEG-TGFSNIPQLIDHHYTTKQVITKKSGVVL 105 >1NRV-A nrPDB Length = 105 Score = 107 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 6/89 (6%) Query: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGD--- 59 WFH +S ++ ++K +G V G FL R S+ N F L++ ++ + +I D Sbjct: 7 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 66 Query: 60 -FYDL-YGGEKFATLTELVEYYTQQQGVL 86 F+ L G KF+ L +LV++Y +GVL Sbjct: 67 TFFSLDDGNTKFSDLIQLVDFYQLNKGVL 95 Score = 52.4 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 45/97 (46%), Gaps = 15/97 (15%) Query: 107 SERWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 ++ W+HG +S ++ +++ +G FL+R+S S P FVL++ ++ Sbjct: 4 TQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL---------CHHQKIK 54 Query: 166 HIKVM--CEGGRYTVG---GLETFDSLTDLVEHFKKT 197 + +++ + G+ G F L LV+ ++ Sbjct: 55 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLN 91 >4M4Z-A nrPDB Length = 170 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 35/116 (30%), Positives = 53/116 (45%), Gaps = 10/116 (8%) Query: 99 PLNCSDPTSERWYHGHMSGGQAETLLQAKGEPW-TFLVRESLSQPGDFVLSVLSDQPKAG 157 P S W + +S +AE LL G P FL+RES ++ G + LSV +P Sbjct: 60 PSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRP--- 116 Query: 158 PGSPLRVTHIKVMC-EGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 S R+ H ++ C + G + TF SL LV+H+ + A L++P Sbjct: 117 -ASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEL----ADDICCLLKEP 167 Score = 79.7 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 32/104 (30%), Positives = 47/104 (45%), Gaps = 13/104 (12%) Query: 4 WFHRDLSGLDAETLLKGRGV-HGSFLARPSRKNQGDFSLSVRVG-----DQVTHIRIQNS 57 W + LS AE LL G G+FL R S+ +G +SLSVR+ D++ H RI Sbjct: 71 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 130 Query: 58 GDF-YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPL 100 + + F +L LV++Y++ D LK P Sbjct: 131 DNGWLYISPRLTFPSLQALVDHYSELA------DDICCLLKEPC 168 >2PLE-A nrPDB Length = 105 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 28/98 (28%), Positives = 47/98 (47%), Gaps = 8/98 (8%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H L+ AE +L G+FL R R +++S R ++ H R+Q G L Sbjct: 11 WYHASLTRAQAEHMLMRVPRDGAFLVR-KRNEPNSYAISFRAEGKIKHCRVQQEGQTVML 69 Query: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 G +F +L +L+ YY + + + L+YP+N Sbjct: 70 -GNSEFDSLVDLISYYEKHPLYRK------MKLRYPIN 100 Score = 83.9 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 30/110 (27%), Positives = 51/110 (46%), Gaps = 15/110 (13%) Query: 106 TSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 S+ WYH ++ QAE +L FLVR+ ++P + +S ++ ++ Sbjct: 7 ESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKR-NEPNSYAISFRAEG---------KIK 56 Query: 166 HIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYA 215 H +V EG +G E FDSL DL+ +++K + + LR P Sbjct: 57 HCRVQQEGQTVMLGNSE-FDSLVDLISYYEKHPLYRK----MKLRYPINE 101 >2LQW-A nrPDB Length = 303 Score = 105 bits (261), Expect = 7e-23, Method: Composition-based stats. Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 1/79 (1%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+ +S +A+T L+G+ HG FL R S GD+ LSV +V+H I + + Sbjct: 14 WYMGPVSRQEAQTRLQGQ-RHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFK 72 Query: 64 YGGEKFATLTELVEYYTQQ 82 G ++F L L+E+Y Sbjct: 73 IGDQEFDHLPALLEFYKIH 91 Score = 88.2 bits (217), Expect = 9e-18, Method: Composition-based stats. Identities = 31/86 (36%), Positives = 44/86 (51%), Gaps = 10/86 (11%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 WY G +S +A+T LQ + FLVR+S + PGD+VLSV + RV+H + Sbjct: 14 WYMGPVSRQEAQTRLQGQRH-GMFLVRDSSTCPGDYVLSVSENS---------RVSHYII 63 Query: 170 MCEGGRYTVGGLETFDSLTDLVEHFK 195 R G + FD L L+E +K Sbjct: 64 NSLPNRRFKIGDQEFDHLPALLEFYK 89 >2OZO-A nrPDB Length = 613 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 101/298 (33%), Gaps = 73/298 (24%) Query: 2 VRWFHRDLSGLDAETLLKGRGV-HGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNS-GD 59 + +F+ +S +AE LK G+ G FL R ++ G + LS+ + H I+ Sbjct: 8 LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 67 Query: 60 FYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN------------------ 101 Y + GG+ EL E+Y+ +D DG +L+ P N Sbjct: 68 TYAIAGGKAHCGPAELCEFYS------RDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDA 121 Query: 102 ----------------------CSDPTSE-----------RWYHGHMSGGQAETLLQAKG 128 P E WYH ++ +AE L + Sbjct: 122 MVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGA 181 Query: 129 E-PWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCE-GGRYTVGGLETFDS 186 + FL+R + G + LS++ + V H + + G+Y + FD+ Sbjct: 182 QTDGKFLLRPR-KEQGTYALSLIYGKT---------VYHYLISQDKAGKYCIPEGTKFDT 231 Query: 187 LTDLVEH--FKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKA 242 L LVE+ K G+ A+ A + L Q DT + Sbjct: 232 LWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNS 289 Score = 54.3 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 28/112 (25%), Positives = 48/112 (42%), Gaps = 16/112 (14%) Query: 104 DPTSE-RWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSP 161 DP + +++G +S +AE L+ G FL+R+ L G +VLS++ D Sbjct: 3 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHD--------- 53 Query: 162 LRVTHIKV-MCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 +R H + G Y + G + +L E + + G LR+P Sbjct: 54 VRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDP----DGLPCNLRKP 101 >4XZ1-A nrPDB Length = 262 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 54/249 (21%), Positives = 90/249 (36%), Gaps = 71/249 (28%) Query: 2 VRWFHRDLSGLDAETLLKGRGV-HGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNS-GD 59 + +F+ +S +AE LK G+ G FL R ++ G + LS+ + H I+ Sbjct: 11 LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 70 Query: 60 FYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN------------------ 101 Y + GG+ EL E+Y+ +D DG +L+ P N Sbjct: 71 TYAIAGGKAHCGPAELCEFYS------RDPDGLPCNLRKPCNRPSGLEPQPGVFDSLRDA 124 Query: 102 ----------------------CSDPTSE-----------RWYHGHMSGGQAETLLQAKG 128 P E WYH ++ +AE L + Sbjct: 125 MVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGA 184 Query: 129 E-PWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCE-GGRYTVGGLETFDS 186 + FL+R + G + LS++ + V H + + G+Y + FD+ Sbjct: 185 QTDGKFLLRPR-KEQGTYALSLIYGKT---------VYHYLISQDKAGKYCIPEGTKFDT 234 Query: 187 LTDLVEHFK 195 L LVE+ K Sbjct: 235 LWQLVEYLK 243 Score = 91.3 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 38/101 (37%), Positives = 48/101 (47%), Gaps = 9/101 (8%) Query: 2 VRWFHRDLSGLDAETLL-KGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGD 59 + W+H L+ +AE L G G FL RP RK QG ++LS+ G V H I Q+ Sbjct: 164 MPWYHSSLTREEAERKLYSGAQTDGKFLLRP-RKEQGTYALSLIYGKTVYHYLISQDKAG 222 Query: 60 FYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPL 100 Y + G KF TL +LVEY DG I LK Sbjct: 223 KYCIPEGTKFDTLWQLVEYLKL------KADGLIYCLKEAC 257 Score = 54.7 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 28/112 (25%), Positives = 48/112 (42%), Gaps = 16/112 (14%) Query: 104 DPTSE-RWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSP 161 DP + +++G +S +AE L+ G FL+R+ L G +VLS++ D Sbjct: 6 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHD--------- 56 Query: 162 LRVTHIKV-MCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 +R H + G Y + G + +L E + + G LR+P Sbjct: 57 VRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDP----DGLPCNLRKP 104 >2CRH-A nrPDB Length = 138 Score = 101 bits (252), Expect = 8e-22, Method: Composition-based stats. Identities = 31/114 (27%), Positives = 53/114 (46%), Gaps = 3/114 (2%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+ + AE++L R G+FL R K+ +F++S++ +V HI+I + Y + Sbjct: 28 WYAGPMERAGAESILANRS-DGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRI 86 Query: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSG 117 + F LTELVE+Y Q + L++P + + G SG Sbjct: 87 TEKKAFRGLTELVEFYQQNSLKDCFKS-LDTTLQFPFKEPEKRTISR-SGPSSG 138 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 30/117 (25%), Positives = 54/117 (46%), Gaps = 11/117 (9%) Query: 104 DPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLR 163 D + WY G M AE++L + + TFLVR+ + +F +S+ + + Sbjct: 22 DLSVHLWYAGPMERAGAESILANRSD-GTFLVRQRVKDAAEFAISIKYN---------VE 71 Query: 164 VTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEA-SGAFVYLRQPYYATRVN 219 V HIK+M G Y + + F LT+LVE +++ +++ L+ P+ Sbjct: 72 VKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKR 128 >2LCT-A nrPDB Length = 107 Score = 99.4 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 30/113 (26%), Positives = 54/113 (47%), Gaps = 11/113 (9%) Query: 104 DPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLR 163 D + WY G M AE++L + + TFLVR+ + +F +S+ + + Sbjct: 5 DLSVHLWYAGPMERAGAESILANRSD-GTFLVRQRVKDAAEFAISIKYN---------VE 54 Query: 164 VTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEA-SGAFVYLRQPYYA 215 V HIK+M G Y + + F LT+LVE +++ +++ L+ P+ Sbjct: 55 VKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKE 107 Score = 99.0 bits (245), Expect = 5e-21, Method: Composition-based stats. Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 2/97 (2%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+ + AE++L R G+FL R K+ +F++S++ +V HI+I + Y + Sbjct: 11 WYAGPMERAGAESILANRS-DGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRI 69 Query: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPL 100 + F LTELVE+Y Q + L++P Sbjct: 70 TEKKAFRGLTELVEFYQQNSLKDCFKS-LDTTLQFPF 105 >2EKX-A nrPDB Length = 110 Score = 95.5 bits (236), Expect = 5e-20, Method: Composition-based stats. Identities = 31/112 (27%), Positives = 50/112 (44%), Gaps = 9/112 (8%) Query: 102 CSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSP 161 S W+ G++S Q+E LL+ KG+ F+VR S SQ G + +S+ S G+ Sbjct: 5 SSGLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGT- 62 Query: 162 LRVTHIKVMC-EGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 V H V + + FDS+ L+ + + ++G LR P Sbjct: 63 --VKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQ----HNSAGMITRLRHP 108 Score = 72.8 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 47/105 (44%), Gaps = 14/105 (13%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRV------GDQVTHIRIQ-N 56 WF ++S +E LL+ +G G+F+ R S G +++S+ V H + N Sbjct: 13 WFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKHYHVHTN 71 Query: 57 SGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 + + L F ++ +L+ Y+ G I L++P++ Sbjct: 72 AENKLYLAENYCFDSIPKLIHYHQHNSA------GMITRLRHPVS 110 >4XI2-A nrPDB Length = 446 Score = 95.1 bits (235), Expect = 8e-20, Method: Composition-based stats. Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 11/117 (9%) Query: 106 TSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 WY HM+ QAE LL+ +G+ F+VR+S S+ G + +SV + G P V Sbjct: 64 EMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAK----STGEPQGVI 118 Query: 166 HIKVMCEG--GRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNA 220 V+C +Y + F ++ +L+ + + ++G L+ P NA Sbjct: 119 RHYVVCSTPQSQYYLAEKHLFSTIPELINYHQ----HNSAGLISRLKYPVSKQNKNA 171 Score = 76.2 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 35/160 (21%), Positives = 63/160 (39%), Gaps = 17/160 (10%) Query: 1 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRV------GDQVTHIRI 54 M W+ + ++ AE LLK G G F+ R S G +++SV + H + Sbjct: 65 MYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGEPQGVIRHYVV 123 Query: 55 QNSGD-FYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPL---NCSDPTSERW 110 ++ Y L F+T+ EL+ Y+ G I LKYP+ N + P++ Sbjct: 124 CSTPQSQYYLAEKHLFSTIPELINYHQHNSA------GLISRLKYPVSKQNKNAPSTAGL 177 Query: 111 YHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVL 150 +G + + F V + G + +++ Sbjct: 178 GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIK 217 >3RO1-A nrPDB Length = 161 Score = 85.9 bits (211), Expect = 5e-17, Method: Composition-based stats. Identities = 27/94 (28%), Positives = 45/94 (47%), Gaps = 15/94 (15%) Query: 418 PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477 PD GVPS+ + +++++ + +VHC GIGRTGTI+ +++ Sbjct: 68 PDGGVPSDSQFLTIMKWLLSEKEGN-------LVHCVGGIGRTGTILASYLIL------- 113 Query: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVA 511 ++++ I VR R G VQT Q F+ Sbjct: 114 -TEGLEVESAIDEVRLVRPGAVQTYEQEMFLLRV 146 >2EYZ-A nrPDB Length = 304 Score = 84.3 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 18/96 (18%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF--- 60 W+ LS +A LL+G+ HG FL R S + GD+ LSV +V+H I +SG Sbjct: 13 WYWGRLSRQEAVALLQGQ-RHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71 Query: 61 --------------YDLYGGEKFATLTELVEYYTQQ 82 G ++F +L L+E+Y Sbjct: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIH 107 Score = 71.6 bits (174), Expect = 9e-13, Method: Composition-based stats. Identities = 33/113 (29%), Positives = 46/113 (40%), Gaps = 29/113 (25%) Query: 101 NCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGS 160 N WY G +S +A LLQ + FLVR+S + PGD+VLSV + Sbjct: 4 NFDSEERSSWYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENS------- 55 Query: 161 PLRVTHIKVMC------------------EGGRYTVGGLETFDSLTDLVEHFK 195 RV+H + R +G + FDSL L+E +K Sbjct: 56 --RVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIG-DQEFDSLPALLEFYK 105 >4E93-A nrPDB Length = 377 Score = 81.6 bits (200), Expect = 8e-16, Method: Composition-based stats. Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 5/98 (5%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+H + + LL G FL R S+ Q ++ LSV H IQ+ + Y L Sbjct: 15 WYHGAIPRAEVAELLV---HSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDNLYRL 70 Query: 64 YGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 GE F ++ L+++ Q L + G ++H P + Sbjct: 71 -EGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKD 107 Score = 63.1 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 32/127 (25%), Positives = 50/127 (39%), Gaps = 16/127 (12%) Query: 99 PLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGP 158 P + WYHG + + LL FLVRES + ++VLSVL D Sbjct: 4 PEVQKPLHEQLWYHGAIPRAEVAELLV---HSGDFLVRESQGKQ-EYVLSVLWDGLP--- 56 Query: 159 GSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEH--FKKTGIEEASGAFVYLRQPYYAT 216 H + Y + G E F S+ L++H + + + SG ++ P Sbjct: 57 ------RHFIIQSLDNLYRLEG-EGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKW 109 Query: 217 RVNAADI 223 +N D+ Sbjct: 110 VLNHEDL 116 >3F41-A nrPDB Length = 629 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 5/81 (6%) Query: 411 HYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLM 470 +Y L+ DH P +P +D+ + +SLP + HC AG+GRT +V+ ++ Sbjct: 202 NYFRLTLQDHFRPDDPD-----VDKFLEFYKSLPKDAWLHYHCYAGMGRTTIFMVMHDIL 256 Query: 471 ENISTKGLDCDIDIQKTIQMV 491 +N D I QK I +V Sbjct: 257 KNAKDVSFDDIIQRQKLIGIV 277 Score = 49.7 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 5/62 (8%) Query: 411 HYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLM 470 HY ++ DH PS +D+ ++P + HC AG GRT + + +M Sbjct: 500 HYYRIAATDHIWPSAAN-----IDEFINFTRTMPANAWLHFHCQAGAGRTTAYMAMYDMM 554 Query: 471 EN 472 +N Sbjct: 555 KN 556 >1MIL-A nrPDB Length = 104 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 24/98 (24%), Positives = 44/98 (44%), Gaps = 5/98 (5%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 WFH LS +AE LL+ ++G FL R S G + L+ Q H+ + + Sbjct: 8 PWFHGKLSRREAEALLQ---LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVR 64 Query: 63 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPL 100 +F +++ L+ Y+ + G+ + L+ P+ Sbjct: 65 -TKDHRFESVSHLISYHMDNHLPIISA-GSELCLQQPV 100 Score = 67.4 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 14/111 (12%) Query: 103 SDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPL 162 S E W+HG +S +AE LLQ G+ FLVRES + PG +VL+ L Sbjct: 2 SQLRGEPWFHGKLSRREAEALLQLNGD---FLVRESTTTPGQYVLTGLQSGQP------- 51 Query: 163 RVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGI-EEASGAFVYLRQP 212 H+ ++ G F+S++ L+ + + ++G+ + L+QP Sbjct: 52 --KHLLLVDPEGVVRT-KDHRFESVSHLISYHMDNHLPIISAGSELCLQQP 99 >2CS0-A nrPDB Length = 119 Score = 69.3 bits (168), Expect = 5e-12, Method: Composition-based stats. Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 4/82 (4%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 WFH +S DAE LL+ + + GSFL R S + G ++LS + H ++ D + Sbjct: 18 WFHGAISREDAENLLESQPL-GSFLIRVSHSHVG-YTLSYKAQSSCCHFMVKLLDDGTFM 75 Query: 64 YGGEKF--ATLTELVEYYTQQQ 83 GEK +L LV ++ Q+ Sbjct: 76 IPGEKVAHTSLDALVTFHQQKP 97 Score = 56.2 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 26/102 (25%), Positives = 41/102 (40%), Gaps = 13/102 (12%) Query: 109 RWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 168 W+HG +S AE LL+++ +FL+R S S G + LS + H Sbjct: 17 EWFHGAISREDAENLLESQ-PLGSFLIRVSHSHVG-YTLSYKAQSSCC---------HFM 65 Query: 169 V-MCEGGRYTV-GGLETFDSLTDLVEHFKKTGIEEASGAFVY 208 V + + G + + G SL LV ++ IE Sbjct: 66 VKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQ 107 >2VIF-A nrPDB Length = 141 Score = 68.5 bits (166), Expect = 7e-12, Method: Composition-based stats. Identities = 27/110 (24%), Positives = 47/110 (42%), Gaps = 7/110 (6%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+ ++ +AE L GSFL R S ++ SLS R + H RI++S + Sbjct: 26 WYWGPITRWEAEGKLANVP-DGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF 84 Query: 64 YGG---EKFATLTELVEYY---TQQQGVLQDRDGTIIHLKYPLNCSDPTS 107 Y E ++ +L+E+ ++ R YP+ ++P S Sbjct: 85 YEQPDVEGHTSIVDLIEHSIGDSENGAFCYSRSRLPGSATYPVRLTNPVS 134 Score = 50.0 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 25/123 (20%), Positives = 46/123 (37%), Gaps = 24/123 (19%) Query: 104 DPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLR 163 + WY G ++ +AE L + +FLVR+S LS S + Sbjct: 20 KLAKQGWYWGPITRWEAEGKLANVPD-GSFLVRDSSDDRYLLSLSFRSHG---------K 69 Query: 164 VTHIKVMCEGGRYTVGGLETFD---SLTDLVEH-----------FKKTGIEEASGAFVYL 209 H ++ GR++ + S+ DL+EH + ++ + ++ V L Sbjct: 70 TLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIGDSENGAFCYSRSRLPGSATYPVRL 129 Query: 210 RQP 212 P Sbjct: 130 TNP 132 >1RPY-A nrPDB Length = 114 Score = 68.2 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 40/97 (41%), Gaps = 2/97 (2%) Query: 3 RWFHRDLSGLDAETLLK--GRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 WFH LS + A L+ G HG F+ R S G+ L+ + H+R+ +G Sbjct: 12 PWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHG 71 Query: 61 YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLK 97 F ++ +++ ++ L+ I L+ Sbjct: 72 QCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLR 108 Score = 51.6 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 45/106 (42%), Gaps = 11/106 (10%) Query: 101 NCSDPTSERWYHGHMSGGQAETLLQAKGE--PWTFLVRESLSQPGDFVLSVLSDQPKAGP 158 + + W+HG +S +A L+ A G F++R+S ++PG+ VL+ Sbjct: 4 MELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQG----- 58 Query: 159 GSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASG 204 + H+++ G F S+ D++ HF I SG Sbjct: 59 ----KAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESG 100 >1KA6-A nrPDB Length = 128 Score = 67.8 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 37/102 (36%), Gaps = 12/102 (11%) Query: 5 FHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLY 64 +H +S E LL G+ GS+L R S G + L V + R+ + Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSA 66 Query: 65 G------GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPL 100 F + L+ + + G +I L+YP+ Sbjct: 67 ETAPGVHKRYFRKIKNLISAFQ------KPDQGIVIPLQYPV 102 Score = 55.4 bits (132), Expect = 7e-08, Method: Composition-based stats. Identities = 28/108 (25%), Positives = 44/108 (40%), Gaps = 19/108 (17%) Query: 111 YHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV- 169 YHG +S E LL A G ++L+R+S S PG + L VL + +V Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGY---------IYTYRVS 57 Query: 170 MCEGGRYTVGG-----LETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 E G ++ F + +L+ F+K G + L+ P Sbjct: 58 QTETGSWSAETAPGVHKRYFRKIKNLISAFQKPD----QGIVIPLQYP 101 >5M6U-B nrPDB Length = 724 Score = 67.8 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 4/98 (4%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W + AE LL+G+ G+FL R S QG ++ SV V +V H I + Y Sbjct: 624 WNVGSSNRNKAENLLRGK-RDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATGYGF 681 Query: 64 YGGEK-FATLTELVEYYTQQQGVLQDRDGTIIHLKYPL 100 +++L ELV +Y ++Q D + L YP+ Sbjct: 682 AEPYNLYSSLKELVLHYQ-HTSLVQHNDSLNVTLAYPV 718 Score = 65.5 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 26/99 (26%), Positives = 47/99 (47%), Gaps = 3/99 (3%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARP-SRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 W+ D+S + L G+FL R S K GD++L++R G I+I + Y Sbjct: 333 WYWGDISREEVNEKL-RDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYG 391 Query: 63 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 F+++ EL+ +Y + + + Q + L YP++ Sbjct: 392 FSDPLTFSSVVELINHY-RNESLAQYNPKLDVKLLYPVS 429 Score = 62.4 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 33/108 (30%), Positives = 46/108 (42%), Gaps = 13/108 (12%) Query: 110 WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV 169 W G + +AE LL+ K + TFLVRES Q G + SV+ D V H + Sbjct: 624 WNVGSSNRNKAENLLRGKRD-GTFLVRESSKQ-GCYACSVVVDG---------EVKHCVI 672 Query: 170 M-CEGGRYTVGGLETFDSLTDLVEHFKKTGIEE-ASGAFVYLRQPYYA 215 G + SL +LV H++ T + + V L P YA Sbjct: 673 NKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 720 Score = 59.3 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 33/153 (21%), Positives = 58/153 (37%), Gaps = 12/153 (7%) Query: 101 NCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRE-SLSQPGDFVLSVLSDQPKAGPG 159 N WY G +S + L+ + TFLVR+ S GD+ L++ Sbjct: 324 NNMSLQDAEWYWGDISREEVNEKLRDTAD-GTFLVRDASTKMHGDYTLTLRKGGNNKL-- 380 Query: 160 SPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEE-ASGAFVYLRQPYYATRV 218 IK+ G+Y TF S+ +L+ H++ + + V L P + Sbjct: 381 -------IKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ 433 Query: 219 NAADIENRVLELNKKQESEDTAKAGFWEEFESL 251 + E+ + + KK +T E++ L Sbjct: 434 DQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRL 466 >2HDV-A nrPDB Length = 111 Score = 67.8 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 2/83 (2%) Query: 3 RWFHRDLSGLDAETLLK--GRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF 60 WFH LS L A L+ G G HG FL R S +G+ L+ + H+R+ + Sbjct: 10 PWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHLRLSLNAAG 69 Query: 61 YDLYGGEKFATLTELVEYYTQQQ 83 F ++ +++E++ Sbjct: 70 QCRVQHLHFQSIFDMLEHFRVHP 92 Score = 52.7 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 25/98 (25%), Positives = 42/98 (42%), Gaps = 11/98 (11%) Query: 109 RWYHGHMSGGQAETLLQA--KGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTH 166 W+HG +S +A L+ G FLVR+S ++ G+ VL+ + H Sbjct: 10 PWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQG---------KAKH 60 Query: 167 IKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASG 204 +++ F S+ D++EHF+ I SG Sbjct: 61 LRLSLNAAGQCRVQHLHFQSIFDMLEHFRVHPIPLESG 98 >1M27-A nrPDB Length = 104 Score = 67.4 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 37/102 (36%), Gaps = 12/102 (11%) Query: 5 FHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLY 64 +H +S E LL G+ GS+L R S G + L V + R+ + Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSA 66 Query: 65 G------GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPL 100 F + L+ + + G +I L+YP+ Sbjct: 67 ETAPGVHKRYFRKIKNLISAFQ------KPDQGIVIPLQYPV 102 Score = 55.1 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 28/108 (25%), Positives = 44/108 (40%), Gaps = 19/108 (17%) Query: 111 YHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKV- 169 YHG +S E LL A G ++L+R+S S PG + L VL + +V Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGY---------IYTYRVS 57 Query: 170 MCEGGRYTVGG-----LETFDSLTDLVEHFKKTGIEEASGAFVYLRQP 212 E G ++ F + +L+ F+K G + L+ P Sbjct: 58 QTETGSWSAETAPGVHKRYFRKIKNLISAFQKPD----QGIVIPLQYP 101 >3CXL-A nrPDB Length = 463 Score = 66.2 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 4/74 (5%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 R FH +S A+ LL GS+L R S++ G ++L++R G Q + R+ G + Sbjct: 52 REFHGMISREAADQLLIV--AEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHF- 108 Query: 63 LYGGEKFATLTELV 76 G ++F ++ +LV Sbjct: 109 -VGEKRFESIHDLV 121 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 47/137 (34%), Gaps = 20/137 (14%) Query: 111 YHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVM 170 +HG +S A+ LL ++L+RES QPG + L++ H Sbjct: 54 FHGMISREAADQLLIVA--EGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFV-- 109 Query: 171 CEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLEL 230 G + F+S+ DLV G+ ++ + Y ++ I V Sbjct: 110 ---------GEKRFESIHDLV----TDGLIT---LYIETKAAEYIAKMTINPIYEHVGYT 153 Query: 231 NKKQESEDTAKAGFWEE 247 +E +E Sbjct: 154 TLNREPAYKKHMPVLKE 170 >1XA6-A nrPDB Length = 466 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 23/74 (31%), Positives = 44/74 (59%), Gaps = 4/74 (5%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 R FH +S A+ LL GV G+++ R S++ G ++L++R G+Q + R+ + G + Sbjct: 56 REFHGIISREQADELLG--GVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHF- 112 Query: 63 LYGGEKFATLTELV 76 G ++F ++ +LV Sbjct: 113 -VGEKRFESIHDLV 125 Score = 50.8 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 49/137 (35%), Gaps = 20/137 (14%) Query: 111 YHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVM 170 +HG +S QA+ LL G +++RES QPG + L++ H Sbjct: 58 FHGIISREQADELLG--GVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFV-- 113 Query: 171 CEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLEL 230 G + F+S+ DLV G+ ++ + Y +++ I + Sbjct: 114 ---------GEKRFESIHDLV----TDGLIT---LYIETKAAEYISKMTTNPIYEHIGYA 157 Query: 231 NKKQESEDTAKAGFWEE 247 +E + E Sbjct: 158 TLLREKVSRRLSRSKNE 174 >1G4W-R nrPDB Length = 383 Score = 60.4 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 32/187 (17%), Positives = 71/187 (37%), Gaps = 21/187 (11%) Query: 329 EATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTT 388 + +M ++ +V+ T E + + PY+ +G + + Sbjct: 194 PDALEAHMKMLLEKECSCLVVLTSEDQMQAKQLPPYFR---GSYTFGEVHTNSQKVSSAS 250 Query: 389 EYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFL-DQINQRQESLP--- 444 + + L G+ I +WPDH P L +L D++ ++ Sbjct: 251 QGEAIDQYNMQLSCGEKRYTIPVLHVKNWPDHQ-PLPSTDQLEYLADRVKNSNQNGAPGR 309 Query: 445 ----HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSG-MV 499 P+I HC G+GRTGT + +++++ + ++++ R R+ M+ Sbjct: 310 SSSDKHLPMI-HCLGGVGRTGT-MAAALVLKD------NPHSNLEQVRADFRDSRNNRML 361 Query: 500 QTEAQYK 506 + +Q+ Sbjct: 362 EDASQFV 368 >6C5X-D nrPDB Length = 164 Score = 60.1 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%) Query: 5 FHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLY 64 + + A LK + G+FL R S++ F++SV+ + IRI+ + L Sbjct: 33 YWGPMDVNVAHDKLKSEPI-GTFLIRDSKQKNCFFAISVKTARETVSIRIKFHAGKFSLD 91 Query: 65 GGEK-FATLTELVEYYTQQQ 83 G ++ F+ L +LVE+Y Sbjct: 92 GSKELFSCLFQLVEHYMTSP 111 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 43/100 (43%), Gaps = 11/100 (11%) Query: 100 LNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPG 159 S + +Y G M A L+++ TFL+R+S + F +SV + + Sbjct: 22 KTSSMLDTCGFYWGPMDVNVAHDKLKSEPI-GTFLIRDSKQKNCFFAISVKTARETVS-- 78 Query: 160 SPLRVTHIKVMCEGGRYTV-GGLETFDSLTDLVEHFKKTG 198 I++ G++++ G E F L LVEH+ + Sbjct: 79 -------IRIKFHAGKFSLDGSKELFSCLFQLVEHYMTSP 111 >4ERC-A nrPDB Length = 150 Score = 59.7 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 30/109 (27%), Positives = 45/109 (41%), Gaps = 16/109 (14%) Query: 412 YQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLME 471 L PD P P + F+ +++ G VHC+ G GRTGT++ Sbjct: 58 LHRLRIPDF-CPPAPDQIDRFVQIVDEANARGEAVG---VHCALGFGRTGTMLA----CY 109 Query: 472 NISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK 520 + +GL I +R R G ++T Q K A+ QF + TK Sbjct: 110 LVKERGLAAG----DAIAEIRRLRPGSIETYEQEK----AVFQFYQRTK 150 >4NX8-A nrPDB Length = 293 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 20/72 (27%), Positives = 33/72 (45%), Gaps = 5/72 (6%) Query: 411 HYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLM 470 Y L+ DH P + +D+ + +LP + HC AG GRT T +V+ ++ Sbjct: 169 QYVRLTVTDHVRPVDSE-----VDRFIESVRALPENAWVHFHCRAGKGRTTTFMVLYDML 223 Query: 471 ENISTKGLDCDI 482 +N T + I Sbjct: 224 KNAKTDSFEEII 235 >4JGH-A nrPDB Length = 173 Score = 57.0 bits (136), Expect = 3e-08, Method: Composition-based stats. Identities = 28/118 (23%), Positives = 56/118 (47%), Gaps = 14/118 (11%) Query: 4 WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDL 63 W+ ++ +A+ LK G+FL R S + ++SV+ T++RI+ + L Sbjct: 23 WYWGSMTVNEAKEKLKEAP-EGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRL 81 Query: 64 YGG-------EKFATLTELVEYY-----TQQQGVLQDRDGTI-IHLKYPLNCSDPTSE 108 ++F ++ L++YY ++ G R+GT+ ++L PL S P+ + Sbjct: 82 DSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQ 139 Score = 50.8 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 25/138 (18%), Positives = 55/138 (39%), Gaps = 29/138 (21%) Query: 109 RWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 168 WY G M+ +A+ L+ + TFL+R+S +SV + ++ Sbjct: 22 GWYWGSMTVNEAKEKLK-EAPEGTFLIRDSSHSDYLLTISVKTSAGPTN---------LR 71 Query: 169 VMCEGGRYTVGGLET-------FDSLTDLVEHFKKTGIEEASG--------AFVYLRQPY 213 + + G++ + + FDS+ L++++ + ++ +G +YL +P Sbjct: 72 IEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPL 131 Query: 214 YATRVNAADIENRVLELN 231 Y + A + L Sbjct: 132 YTS----APSLQHLCRLT 145 >3QWY-A nrPDB Length = 308 Score = 56.6 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 36/87 (41%), Gaps = 12/87 (13%) Query: 5 FHRDLSGLDAETLLKGRGVH-GSFLARPSRKNQGDFSLSVR---VGDQVTHIRIQNSGDF 60 + +S +A LL V G+FL R S G++SL+VR G+ V H I+ Sbjct: 44 YFPGMSREEAHKLLGEPQVSIGTFLMRDS-SRPGEYSLTVREADEGNAVCHYLIERGEPK 102 Query: 61 YD-------LYGGEKFATLTELVEYYT 80 D + F + L+ ++ Sbjct: 103 EDGTAAAGVKIANQSFPDIPALLNHFK 129 Score = 51.6 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 43/183 (23%), Positives = 64/183 (34%), Gaps = 30/183 (16%) Query: 101 NCSDP-TSERWYHGHMSGGQAETLLQAKGEP-WTFLVRESLSQPGDFVLSVLSDQPKAGP 158 N DP +Y MS +A LL TFL+R+S S+PG++ L+V Sbjct: 33 NGFDPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDS-SRPGEYSLTVRE------A 85 Query: 159 GSPLRVTHIKVMC----EGGRYTVGGLET---FDSLTDLVEHFKKTGIEEASGAFVYLRQ 211 V H + E G G F + L+ HFK + EAS Sbjct: 86 DEGNAVCHYLIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFKMRVLTEAS-------- 137 Query: 212 PYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQR----LEGQR 267 A + ++ + ++E++ + G E E L K R G Sbjct: 138 LLAAYKKPIIEVVVGTFKFTGERETDLPFEQG--ERLEILSKTNQDWWEARNALGTTGLV 195 Query: 268 PEN 270 P N Sbjct: 196 PAN 198 >6C7Y-B nrPDB Length = 117 Score = 56.6 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 23/80 (28%), Positives = 36/80 (45%), Gaps = 2/80 (2%) Query: 5 FHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLY 64 + L+ A LK G+FL R S + F++SV+ T IRI + L Sbjct: 29 YWGPLTVSAAHEKLKSEP-EGTFLIRDSTQKNCFFAISVKTATGPTSIRINFQTGRFSLD 87 Query: 65 GGEK-FATLTELVEYYTQQQ 83 G ++ F L +L+E+Y Sbjct: 88 GSKETFDCLFKLLEHYLSSP 107 Score = 50.8 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 11/91 (12%) Query: 109 RWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 168 +Y G ++ A L+++ E TFL+R+S + F +SV + I+ Sbjct: 27 GFYWGPLTVSAAHEKLKSEPE-GTFLIRDSTQKNCFFAISVKTATGPTS---------IR 76 Query: 169 VMCEGGRYTV-GGLETFDSLTDLVEHFKKTG 198 + + GR+++ G ETFD L L+EH+ + Sbjct: 77 INFQTGRFSLDGSKETFDCLFKLLEHYLSSP 107 >2BBU-A nrPDB Length = 164 Score = 55.1 bits (131), Expect = 8e-08, Method: Composition-based stats. Identities = 23/87 (26%), Positives = 38/87 (43%), Gaps = 8/87 (9%) Query: 5 FHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLY 64 + ++G +A LL G+FL R S + F+LSV+ ++RIQ G + L Sbjct: 26 YWSAVTGGEANLLLSAEPA-GTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQ 84 Query: 65 GG-------EKFATLTELVEYYTQQQG 84 +F + +LV +Y G Sbjct: 85 SDPRSTQPVPRFDCVLKLVHHYMPPPG 111 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 26/98 (26%), Positives = 42/98 (42%), Gaps = 17/98 (17%) Query: 104 DPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLR 163 +Y ++GG+A LL A+ TFL+R+S Q F LSV + Sbjct: 19 KLQESGFYWSAVTGGEANLLLSAE-PAGTFLIRDSSDQRHFFTLSVKTQSGTKN------ 71 Query: 164 VTHIKVMCEGGRYTVGGL-------ETFDSLTDLVEHF 194 +++ CEGG +++ FD + LV H+ Sbjct: 72 ---LRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 106 >4GL9-E nrPDB Length = 143 Score = 54.3 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 30/112 (26%), Positives = 45/112 (40%), Gaps = 10/112 (8%) Query: 5 FHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLY 64 + ++G +A LL G+FL R S + F+LSV+ ++RIQ G + L Sbjct: 31 YWSAVTGGEANLLLSAEPA-GTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQ 89 Query: 65 GG-------EKFATLTELVEYYTQQQGVLQDRDGTIIH--LKYPLNCSDPTS 107 +F + +LV +Y R I K PL S P S Sbjct: 90 SDPRSTQPVPRFDCVLKLVHHYMGSGSGSGSRAYYIYSGGEKIPLVLSRPLS 141 Score = 49.7 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 26/98 (26%), Positives = 42/98 (42%), Gaps = 17/98 (17%) Query: 104 DPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLR 163 +Y ++GG+A LL A+ TFL+R+S Q F LSV + Sbjct: 24 KLQESGFYWSAVTGGEANLLLSAE-PAGTFLIRDSSDQRHFFTLSVKTQSGTKN------ 76 Query: 164 VTHIKVMCEGGRYTVGGL-------ETFDSLTDLVEHF 194 +++ CEGG +++ FD + LV H+ Sbjct: 77 ---LRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 111 >2HMH-A nrPDB Length = 152 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 8/83 (9%) Query: 5 FHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLY 64 + ++G +A LL G+FL R S + F+LSV+ ++RIQ G + L Sbjct: 37 YWSAVTGGEANLLLSAEPA-GTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQ 95 Query: 65 GG-------EKFATLTELVEYYT 80 +F + +LV +Y Sbjct: 96 SDPRSTQPVPRFDCVLKLVHHYM 118 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 26/98 (26%), Positives = 42/98 (42%), Gaps = 17/98 (17%) Query: 104 DPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLR 163 +Y ++GG+A LL A+ TFL+R+S Q F LSV + Sbjct: 30 KLQESGFYWSAVTGGEANLLLSAE-PAGTFLIRDSSDQRHFFTLSVKTQSGTKN------ 82 Query: 164 VTHIKVMCEGGRYTVGGL-------ETFDSLTDLVEHF 194 +++ CEGG +++ FD + LV H+ Sbjct: 83 ---LRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 117 >5Z59-A nrPDB Length = 147 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 12/91 (13%) Query: 418 PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477 PD PS +L L I +R +++HC G+GR+GT+ V ++ Sbjct: 62 PDFTAPS-VEQLLEILRWIEERVREGKK---VLIHCMGGLGRSGTVGVAWLM-------- 109 Query: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFI 508 + +++ + VR +R G V+T+ Q + + Sbjct: 110 YSRGLSLREALMEVRRKRPGAVETQEQMEVL 140 >5XW4-A nrPDB Length = 415 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 32/76 (42%), Gaps = 9/76 (11%) Query: 436 INQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQR 495 + + + G I VHC AG+GRTG +I ++ + I +R R Sbjct: 307 VGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLI--------YTYGFTANECIGFLRFIR 358 Query: 496 SGMVQTEAQ-YKFIYV 510 GMV Q + +++ Sbjct: 359 PGMVVGPQQHWLYLHQ 374 >3D1Q-A nrPDB Length = 340 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 16/56 (28%), Positives = 25/56 (44%), Gaps = 10/56 (17%) Query: 417 WPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMEN 472 WP P L+F +LP + HC AG+GRT +V+ +++N Sbjct: 220 WP---TPENIDRFLAF-------YRTLPQDAWLHFHCEAGVGRTTAFMVMTDMLKN 265 >3RZ2-A nrPDB Length = 189 Score = 49.3 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 25/116 (21%), Positives = 45/116 (38%), Gaps = 12/116 (10%) Query: 385 HDTTEYKLRTL-QVSPLDNGDLIREIWHYQYLSWP-DHGVPSEPGGVLSFLDQINQRQES 442 + +Y + T+ +V + E L WP D G P V +L + + Sbjct: 55 EELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFRE 114 Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGM 498 P I VHC AG+GR ++ + ++ + + +Q +R +R G Sbjct: 115 EPGCC-IAVHCVAGLGRAPVLVALALIEGGMKYE---------DAVQFIRQKRRGA 160 >1ZCK-A nrPDB Length = 154 Score = 49.3 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 25/116 (21%), Positives = 45/116 (38%), Gaps = 12/116 (10%) Query: 385 HDTTEYKLRTL-QVSPLDNGDLIREIWHYQYLSWP-DHGVPSEPGGVLSFLDQINQRQES 442 + +Y + T+ +V + E L WP D G P V +L + + Sbjct: 29 EELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFRE 88 Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGM 498 P I VHC AG+GR ++ + ++ + + +Q +R +R G Sbjct: 89 EPGCC-IAVHCVAGLGRAPVLVALALIEGGMKYE---------DAVQFIRQKRRGA 134 >5LXQ-B nrPDB Length = 196 Score = 49.3 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 25/116 (21%), Positives = 45/116 (38%), Gaps = 12/116 (10%) Query: 385 HDTTEYKLRTL-QVSPLDNGDLIREIWHYQYLSWP-DHGVPSEPGGVLSFLDQINQRQES 442 + +Y + T+ +V + E L WP D G P V +L + + Sbjct: 58 EELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFRE 117 Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGM 498 P I VHC AG+GR ++ + ++ + + +Q +R +R G Sbjct: 118 EPGCC-IAVHCVAGLGRAPVLVALALIEGGMKYE---------DAVQFIRQKRRGA 163 >5K23-A nrPDB Length = 189 Score = 48.9 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 26/120 (21%), Positives = 46/120 (38%), Gaps = 12/120 (10%) Query: 381 NCGEHDTTEYKLRTL-QVSPLDNGDLIREIWHYQYLSWP-DHGVPSEPGGVLSFLDQINQ 438 N + +Y + TL +V E L WP D G P V +L+ + Sbjct: 50 NKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKT 109 Query: 439 RQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGM 498 + P + VHC AG+GR ++ + ++ + + +Q +R +R G Sbjct: 110 KFREEPGCC-VAVHCVAGLGRAPVLVALALIECGMKYE---------DAVQFIRQKRRGA 159 >5K22-A nrPDB Length = 183 Score = 48.5 bits (114), Expect = 8e-06, Method: Composition-based stats. Identities = 27/120 (22%), Positives = 47/120 (39%), Gaps = 12/120 (10%) Query: 381 NCGEHDTTEYKLRTL-QVSPLDNGDLIREIWHYQYLSWP-DHGVPSEPGGVLSFLDQINQ 438 N + +Y + TL +V E L WP D G P V +L+ + Sbjct: 48 NKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKT 107 Query: 439 RQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGM 498 + P A + VHC AG+GR ++ + ++ + + +Q +R +R G Sbjct: 108 KFREEPGAA-VAVHCVAGLGRAPVLVALALIEAGMKYE---------DAVQFIRQKRRGA 157 >2EL8-A nrPDB Length = 118 Score = 46.6 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 36/81 (44%), Gaps = 6/81 (7%) Query: 8 DLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVR--VGDQ--VTHIRIQNSGDFYDL 63 +S L+A+ LL+ G+ L RPS S++ R V H +++ G Y + Sbjct: 27 KVSRLEAQLLLERYPECGNLLLRPSGDGADGVSVTTRQMHNGTHVVRHYKVKREGPKYVI 86 Query: 64 YGGEKFA--TLTELVEYYTQQ 82 + F+ +L +V Y+ Sbjct: 87 DVEQPFSCTSLDAVVNYFVSH 107 Score = 38.9 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 7/83 (8%) Query: 114 HMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEG 173 +S +A+ LL+ E L+R S GD V + G+ + V H KV EG Sbjct: 27 KVSRLEAQLLLERYPECGNLLLRPS----GDGADGVSVTTRQMHNGTHV-VRHYKVKREG 81 Query: 174 GRYTVGGLETFD--SLTDLVEHF 194 +Y + + F SL +V +F Sbjct: 82 PKYVIDVEQPFSCTSLDAVVNYF 104 >1FPZ-A nrPDB Length = 212 Score = 46.6 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 46/103 (44%), Gaps = 14/103 (13%) Query: 409 IWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDM 468 I H+ ++ D G P + ++++ ++ ++H G+GR+ ++ + Sbjct: 102 ITHHHPIA--DGGTP-DIASCCEIMEELTTCLKNYRKT---LIHSYGGLGRS-CLVAACL 154 Query: 469 LMENISTKGLDCDIDIQKTIQMVRAQR-SGMVQTEAQYKFIYV 510 L+ L I ++ I +R R SG +QT QY +++ Sbjct: 155 LLY------LSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHE 191 >1OHC-A nrPDB Length = 348 Score = 46.2 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 24/86 (27%), Positives = 35/86 (40%), Gaps = 15/86 (17%) Query: 419 DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGL 478 D P++ + + E+ G I VHC AG+GRTGT+I ++ Sbjct: 249 DGSTPTDA-----IVKEFLDICENA--EGAIAVHCKAGLGRTGTLIACYIM--------K 293 Query: 479 DCDIDIQKTIQMVRAQRSGMVQTEAQ 504 + +TI VR R G V Q Sbjct: 294 HYRMTAAETIAWVRICRPGSVIGPQQ 319 >3S4O-A nrPDB Length = 167 Score = 45.8 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 58/165 (35%), Gaps = 26/165 (15%) Query: 361 CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYK-------LRTL-QVSPLDNGDLIREIWHY 412 C P+ + + + + Y +R L +V + + Sbjct: 13 CD---PQKPSRVLFHFLILDAPSPSNLPTYIKELQHRGVRHLVRVCGPTYDATLVKSRGI 69 Query: 413 QYLSWP-DHGVPSEP---GGVLSFLDQINQRQESLPHAGP--IIVHCSAGIGRTGTIIVI 466 SWP D G P L LD RQ+ P P I VHC AG+GR ++ + Sbjct: 70 DVHSWPFDDGAPPTRAVLDSWLKLLDTELARQQEDPSVPPPTIGVHCVAGLGRAPILVAL 129 Query: 467 DMLMENISTKGLDCDIDIQKTIQMVRAQRSGMV-QTEAQYKFIYV 510 ++ ++ I ++R +R G + QT+ + Y Sbjct: 130 ALV--------EYGNVSALDAIALIREKRKGAINQTQMHWITKYK 166 >1XM2-A nrPDB Length = 173 Score = 45.4 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 44/116 (37%), Gaps = 12/116 (10%) Query: 385 HDTTEYKLRTL-QVSPLDNGDLIREIWHYQYLSWP-DHGVPSEPGGVLSFLDQINQRQES 442 + +Y + T+ +V + E L WP D G P V +L + + Sbjct: 35 EELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFRE 94 Query: 443 LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGM 498 P I VH AG+GR ++ + ++ + + +Q +R +R G Sbjct: 95 EPGCC-IAVHSVAGLGRAPVLVALALIEGGMKYE---------DAVQFIRQKRRGA 140 >1V3A-A nrPDB Length = 173 Score = 45.4 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 20/86 (23%), Positives = 37/86 (43%), Gaps = 11/86 (12%) Query: 415 LSWP-DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENI 473 + WP D G P V +L + + P + + VHC AG+GR ++ + ++ + Sbjct: 66 VDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSC-VAVHCVAGLGRAPVLVALALIESGM 124 Query: 474 STKGLDCDIDIQKTIQMVRAQRSGMV 499 + IQ +R +R G + Sbjct: 125 KYE---------DAIQFIRQKRRGAI 141 >4TVV-A nrPDB Length = 314 Score = 45.0 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 17/70 (24%), Positives = 29/70 (41%), Gaps = 5/70 (7%) Query: 419 DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGL 478 DH P + +D + ++ P VHC G GRT T+ + +++N Sbjct: 197 DHRAPLDSE-----VDALVALIKNNPEDTWYHVHCRGGKGRTTTVFAMFDMLKNADKVSF 251 Query: 479 DCDIDIQKTI 488 + I Q +I Sbjct: 252 EEIIARQASI 261 >3V0J-A nrPDB Length = 334 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 22/90 (24%), Positives = 36/90 (40%), Gaps = 6/90 (6%) Query: 419 DHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGL 478 DH VP+ +L F+D S P I +H G GRTGT++ + Sbjct: 94 DHNVPTLVD-LLKFIDDAKVWMTSDPDHV-IAIHSKGGKGRTGTLVSS----WLLEDGKF 147 Query: 479 DCDIDIQKTIQMVRAQRSGMVQTEAQYKFI 508 D + + R V+T +Q +++ Sbjct: 148 DTAKEALEYFGSRRTDVFQGVETASQIRYV 177 >5BZX-A nrPDB Length = 314 Score = 42.0 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 46/137 (33%), Gaps = 8/137 (5%) Query: 379 VTNCGEHDTTEYKLRTLQVSPL-DNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQIN 437 V YK+ L D + Y + DH P ++ + Sbjct: 41 VRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFE---DHNPPQ--LELIKPFCEDL 95 Query: 438 QRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSG 497 + S +HC AG GRTG +I L+ +D ++ R ++ Sbjct: 96 DQWLSEDDNHVAAIHCKAGKGRTGVMICAY-LLHRGKFLKAQEALDFYGEVRT-RDKKGV 153 Query: 498 MVQTEAQYKFIYVAIAQ 514 + ++ +Y + Y + + Sbjct: 154 TIPSQRRYVYYYSYLLK 170 >2IZV-A nrPDB Length = 187 Score = 42.0 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 5/82 (6%) Query: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62 + + AE LL+G+ G+FL R S + FS+S R + H RI+ + Sbjct: 35 PCYWGVMDKYAAEALLEGKP-EGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFS 93 Query: 63 LYGGEK--FA--TLTELVEYYT 80 + F +T L+E+Y Sbjct: 94 FDAHDPCVFHSPDITGLLEHYK 115 Score = 35.0 bits (79), Expect = 0.086, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 39/110 (35%), Gaps = 21/110 (19%) Query: 111 YHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVM 170 Y G M AE LL+ K E TFL+R+S + F +S H ++ Sbjct: 37 YWGVMDKYAAEALLEGKPE-GTFLLRDSAQEDYLFSVSFRRYSRSL---------HARIE 86 Query: 171 C--EGGRYTVGGLETFDS--LTDLVEHFKKTGIEEASGAFVYLRQPYYAT 216 + F S +T L+EH+K +P +T Sbjct: 87 QWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSA-------CMFFEPLLST 129 >2RF6-A nrPDB Length = 176 Score = 42.0 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 12/72 (16%), Positives = 33/72 (45%), Gaps = 1/72 (1%) Query: 422 VPSEPGGVLSFLDQINQRQESL-PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 480 V + + D + P++VH +AG+ R+G +I+ ++ +N + + Sbjct: 83 VDDTTTDISKYFDDVTAFLSKCDQRNEPVLVHSAAGVNRSGAMILAYLMSKNKESLPMLY 142 Query: 481 DIDIQKTIQMVR 492 + + +++ +R Sbjct: 143 FLYVYHSMRDLR 154 >3MAZ-A nrPDB Length = 125 Score = 41.6 bits (96), Expect = 9e-04, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 40/80 (50%), Gaps = 8/80 (10%) Query: 9 LSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVG---DQVTHIRIQNSGDFYDLYG 65 +S +A +L+ G+ + RP + ++S+++R ++ H ++ + G Y + Sbjct: 22 VSRKEATEMLQKNPSLGNMILRPG-SDSRNYSITIRQEIDIPRIKHYKVMSVGQNYTI-E 79 Query: 66 GEKFATLTEL---VEYYTQQ 82 EK TL L ++Y+ ++ Sbjct: 80 LEKPVTLPNLFSVIDYFVKE 99 >1UUS-A nrPDB Length = 473 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 31/79 (39%), Gaps = 11/79 (13%) Query: 6 HRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLS---VRVGDQVTHIRIQNSGDFY- 61 + + + L+ + G+F+ R S +N G F ++ V + ++ H +Q + Sbjct: 355 YGYMGRQEVNDALQNQDP-GTFIIRFSERNPGQFGIAYIGVEMPARIKHYLVQPNDTAAA 413 Query: 62 ------DLYGGEKFATLTE 74 L +F L + Sbjct: 414 KKTFPDFLSEHSQFVNLLQ 432 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 16/122 (13%) Query: 93 IIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSD 152 + L+Y + S E +G+M + LQ + +P TF++R S PG F ++ Sbjct: 336 MQTLRYQRHISTLWQEGIIYGYMGRQEVNDALQNQ-DPGTFIIRFSERNPGQFGIA---- 390 Query: 153 QPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGI----EEASGAFVY 208 G P R+ H V T +TF L EH + + ++ +GA + Sbjct: 391 --YIGVEMPARIKHYLVQPND---TAAAKKTFPDF--LSEHSQFVNLLQWTKDTNGAPRF 443 Query: 209 LR 210 L+ Sbjct: 444 LK 445 >2CR4-A nrPDB Length = 126 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 21/98 (21%), Positives = 35/98 (35%), Gaps = 12/98 (12%) Query: 13 DAETLLK-----GRGVHGSFLARPSRKNQGDFSLSVRVG--DQVTHIRIQNSGDFYDLYG 65 + E L K G G + R S G L V ++V + RI + L G Sbjct: 28 EVERLFKATSPRGEPQDGLYCIRNSSTKSGK-VLVVWDETSNKVRNYRIFEKDSKFYLEG 86 Query: 66 GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCS 103 F ++ +VE+Y + L++P + Sbjct: 87 EVLFVSVGSMVEHYHTHVLPSHQS----LLLRHPYGYT 120 Score = 39.6 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 38/89 (42%), Gaps = 10/89 (11%) Query: 125 QAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETF 184 + + + + +R S ++ G VL V + +V + ++ + ++ + G F Sbjct: 39 RGEPQDGLYCIRNSSTKSGK-VLVVWDETSN-------KVRNYRIFEKDSKFYLEGEVLF 90 Query: 185 DSLTDLVEHFKKTGIEEASGAFVYLRQPY 213 S+ +VEH+ + + LR PY Sbjct: 91 VSVGSMVEHYHTHVLPSHQS--LLLRHPY 117 >2WGP-A nrPDB Length = 190 Score = 40.4 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 14/60 (23%), Positives = 30/60 (50%), Gaps = 3/60 (5%) Query: 411 HYQYLSWPDHGVPSEPGGVLSFLDQINQR-QESLPHAGPIIVHCSAGIGRTGTIIVIDML 469 ++Y+ P +P P G+ + D + + G +VHC+AG+ R+ T+ + ++ Sbjct: 69 QFEYVKVPLADMPHAPIGL--YFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM 126 >2G6Z-A nrPDB Length = 211 Score = 39.6 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 23/108 (21%), Positives = 39/108 (36%), Gaps = 20/108 (18%) Query: 397 VSPLDNGDLIREIWHYQYLSWP---DH--GVPSEPGGVLSFLDQINQRQESLPHAGPIIV 451 + + + H Y P H + S + F+D + ++ G ++V Sbjct: 35 LLNVSRRTSEACMTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKG------GKVLV 88 Query: 452 HCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMV 499 H AGI R+ TI + + TK + I+ QR MV Sbjct: 89 HSEAGISRSPTIC----MAYLMKTKQFRLK-EAFDYIK----QRRSMV 127 >4R0S-A nrPDB Length = 218 Score = 37.7 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 22/88 (25%), Positives = 35/88 (39%), Gaps = 14/88 (15%) Query: 415 LSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML----- 469 LS P H + VLS L Q+ + GP+++HC G RTG + + Sbjct: 98 LSLPTHADRVDDAEVLSVLRQLQAAER----EGPVLMHCKHGNNRTGLFAAMYRIVVQGW 153 Query: 470 -----MENISTKGLDCDIDIQKTIQMVR 492 +E + G + D++ VR Sbjct: 154 DKQAALEEMQHGGFGDEDDMRDASAYVR 181 >2M3V-A nrPDB Length = 193 Score = 36.6 bits (83), Expect = 0.034, Method: Composition-based stats. Identities = 21/88 (23%), Positives = 35/88 (39%), Gaps = 14/88 (15%) Query: 415 LSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML----- 469 +S P H + VLS L Q+ + GP+++HC G RTG + + Sbjct: 73 VSLPTHADRVDDAEVLSVLRQLQAAER----EGPVLMHCKHGNNRTGLFAAMYRIVVQGW 128 Query: 470 -----MENISTKGLDCDIDIQKTIQMVR 492 +E + G + D++ VR Sbjct: 129 DKQAALEEMQRGGFGDEDDMRDASAYVR 156 >2OZ5-A nrPDB Length = 296 Score = 35.8 bits (81), Expect = 0.056, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 30/59 (50%), Gaps = 11/59 (18%) Query: 448 PIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQ------MVRAQRSGMVQ 500 P++ HC AG RTG ++ + + GLD D+ + ++ +RA+ S M+Q Sbjct: 175 PVLTHCFAGKDRTGFVVAL-----VLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQ 228 >3EZZ-A nrPDB Length = 144 Score = 35.4 bits (80), Expect = 0.078, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 23/42 (54%), Gaps = 6/42 (14%) Query: 430 LSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLME 471 + ++D + + G ++VH AGI R+ TI + ++M+ Sbjct: 71 IEYIDAVKDCR------GRVLVHSQAGISRSATICLAYLMMK 106 >1YN9-A nrPDB Length = 169 Score = 34.6 bits (78), Expect = 0.14, Method: Composition-based stats. Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 3/70 (4%) Query: 431 SFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQM 490 F+D + + E P + VHC+ GI RTG +V LM + ID + + Sbjct: 99 EFIDTVKEFTEKCPGML-VGVHCTHGINRTG-YMVCRYLMHTLGI-APQEAIDRFEKARG 155 Query: 491 VRAQRSGMVQ 500 + +R VQ Sbjct: 156 HKIERQNYVQ 165 >5IXI-A nrPDB Length = 544 Score = 34.3 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 22/88 (25%), Positives = 46/88 (52%), Gaps = 3/88 (3%) Query: 112 HGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLS-DQPKAGPGSPLRVTHIKV 169 HG + A L+ +G E +++R S + + +++V ++ + G+ + + ++ Sbjct: 423 HGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQI 482 Query: 170 MCEGGRYTV-GGLETFDSLTDLVEHFKK 196 + GRY++ G +F SL DL+ H KK Sbjct: 483 EVQKGRYSLHGSDRSFPSLGDLMSHLKK 510 >4YR8-G nrPDB Length = 167 Score = 34.3 bits (77), Expect = 0.18, Method: Composition-based stats. Identities = 15/47 (31%), Positives = 29/47 (61%), Gaps = 2/47 (4%) Query: 429 VLSFLDQ-INQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENIS 474 +L +LD+ ++ +++ G ++VHC AGI R+ T I I +M+ + Sbjct: 85 ILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSAT-IAIAYIMKRMD 130 >4ZYJ-A nrPDB Length = 425 Score = 34.3 bits (77), Expect = 0.18, Method: Composition-based stats. Identities = 27/123 (21%), Positives = 42/123 (34%), Gaps = 22/123 (17%) Query: 91 GTIIHLKYPLNCSDPTSERWYHG-HMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSV 149 G + L + W HG + AE LL+ G G+ V+ Sbjct: 119 GVALALHMQFSRGLTLDFEWRHGAPSTRPLAEDLLRQMG-------------AGEAVIC- 164 Query: 150 LSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYL 209 G +R T + G Y + G +T S+ + H+ + E +GA V L Sbjct: 165 -------GAVKDVRGTTVLTRATDGSYRLNGRKTLVSMAGIATHYVVSTRLEEAGAPVRL 217 Query: 210 RQP 212 P Sbjct: 218 AAP 220 >6D67-A nrPDB Length = 520 Score = 33.5 bits (75), Expect = 0.25, Method: Composition-based stats. Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 11/67 (16%) Query: 411 HYQYLSWP---DH--GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIV 465 HYQY S P +H + S + F+D I G + VH AGI R+ TI + Sbjct: 417 HYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAG------GRVFVHSQAGISRSATICL 470 Query: 466 IDMLMEN 472 ++ N Sbjct: 471 AYLMRTN 477 >2Q47-A nrPDB Length = 151 Score = 33.1 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 18/110 (16%), Positives = 37/110 (33%), Gaps = 27/110 (24%) Query: 392 LRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIV 451 +R Q N + +++ PDH + ++ +++ P+++ Sbjct: 58 IRLFQFGIEGNKEP--------FVNIPDHK--------IRMALKVLLDEKN----HPVLI 97 Query: 452 HCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQK----TIQMVRAQRSG 497 HC G RTG ++ + + L D + V QR Sbjct: 98 HCKRGKHRTGCLVG---CLRKLQKWCLTSIFDEYQRFAAAKARVSDQRFM 144 >2ESB-A nrPDB Length = 188 Score = 33.1 bits (74), Expect = 0.35, Method: Composition-based stats. Identities = 15/64 (23%), Positives = 26/64 (40%), Gaps = 5/64 (7%) Query: 412 YQYLSWPDHGVPSEPGGVL-SFLDQIN-QRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 469 QY+ P V P L F D I G ++HC+AG+ R+ + + ++ Sbjct: 64 IQYMQVP---VADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLM 120 Query: 470 MENI 473 + Sbjct: 121 KYHA 124 >6N8N-Y nrPDB Length = 364 Score = 32.7 bits (73), Expect = 0.41, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 19/46 (41%), Gaps = 8/46 (17%) Query: 424 SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 469 ++ F + P G + HC AG+ R+ T IV ++ Sbjct: 96 EYSPRLVDFKKK--------PQRGAVFAHCQAGLSRSVTFIVAYLM 133 >2J16-A nrPDB Length = 182 Score = 32.3 bits (72), Expect = 0.56, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 25/61 (40%), Gaps = 5/61 (8%) Query: 412 YQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLME 471 Y + W +H + L + + I++HC G+ R+ T+I+ ++ Sbjct: 88 YHHYRW-EH----DSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKY 142 Query: 472 N 472 + Sbjct: 143 H 143 >4EVC-A nrPDB Length = 164 Score = 32.3 bits (72), Expect = 0.62, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 33/80 (41%) Query: 508 IYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENL 567 ++ A + E + L + Q + +T A+K K +S H +D+++ + Sbjct: 56 VHKATEEIYEGFADMFDDLAERIAQLGHHPLVTLSEALKLTRVKEETKTSFHSKDIFKEI 115 Query: 568 HTKNKREEKVKKQRSADKEK 587 K EK K+ S EK Sbjct: 116 LEDYKHLEKEFKELSNTAEK 135 >1ZZW-A nrPDB Length = 149 Score = 31.9 bits (71), Expect = 0.70, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 23/44 (52%), Gaps = 5/44 (11%) Query: 449 IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVR 492 +++HC AG+ R+ T IVI LM++ D K ++ R Sbjct: 86 LLIHCQAGVSRSAT-IVIAYLMKHTR----MTMTDAYKFVKGKR 124 >5GTJ-A nrPDB Length = 181 Score = 31.9 bits (71), Expect = 0.70, Method: Composition-based stats. Identities = 10/49 (20%), Positives = 26/49 (53%), Gaps = 8/49 (16%) Query: 447 GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQR 495 G I+VH + G+ R+ T+++ +++ + + + + I+ V+ R Sbjct: 108 GKILVHSAVGVSRSATLVLAYLMLYH--------HLTLVEAIKKVKDHR 148 >3ZIF-N nrPDB Length = 125 Score = 31.9 bits (71), Expect = 0.70, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 32/81 (39%), Gaps = 5/81 (6%) Query: 515 FIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKRE 574 ++ K K + G + PP +++A RT + E +NLH + R Sbjct: 11 YVTARLPKWSGSVQDKTGSNMLGGVVLPP-----NSQAHRTETVGTEATRDNLHAEGARR 65 Query: 575 EKVKKQRSADKEKSKGSLKRK 595 + + E S G LKR+ Sbjct: 66 PEDQTPYMILVEDSLGGLKRR 86 >1M3G-A nrPDB Length = 145 Score = 31.9 bits (71), Expect = 0.71, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 26/63 (41%), Gaps = 11/63 (17%) Query: 430 LSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQ 489 + F+D + G ++VH AGI R+ TI + ++ LD D ++ Sbjct: 71 IGFIDWVKNSG------GRVLVHSQAGISRSATICLAYLM--QSRRVRLDEAFD---FVK 119 Query: 490 MVR 492 R Sbjct: 120 QRR 122 >4B04-A nrPDB Length = 160 Score = 31.9 bits (71), Expect = 0.72, Method: Composition-based stats. Identities = 10/49 (20%), Positives = 26/49 (53%), Gaps = 8/49 (16%) Query: 447 GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQR 495 G I+VH + G+ R+ T+++ +++ + + + + I+ V+ R Sbjct: 87 GKILVHSAVGVSRSATLVLAYLMLYH--------HLTLVEAIKKVKDHR 127 >2OUD-A nrPDB Length = 177 Score = 31.9 bits (71), Expect = 0.72, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 23/44 (52%), Gaps = 5/44 (11%) Query: 449 IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVR 492 +++HC AG+ R+ T IVI LM++ D K ++ R Sbjct: 90 LLIHCQAGVSRSAT-IVIAYLMKHTR----MTMTDAYKFVKGKR 128 >4JMK-A nrPDB Length = 152 Score = 31.9 bits (71), Expect = 0.82, Method: Composition-based stats. Identities = 17/63 (26%), Positives = 30/63 (47%), Gaps = 11/63 (17%) Query: 430 LSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQ 489 + F+D+ + +IVH AGI R+ T I I +M+ + G+ D D + ++ Sbjct: 71 IEFIDKAK------LSSCQVIVHSLAGISRSAT-IAIAYIMKTM---GMSSD-DAYRFVK 119 Query: 490 MVR 492 R Sbjct: 120 DRR 122 >6FEY-A nrPDB Length = 242 Score = 31.9 bits (71), Expect = 0.86, Method: Composition-based stats. Identities = 26/152 (17%), Positives = 48/152 (31%), Gaps = 7/152 (4%) Query: 73 TELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAK--GEP 130 + +++ LQ DG I + + S S +W GH+ + + L + E Sbjct: 30 ADWLKFTKTPPTKLQQADGATIEIVCEMMGSQVPSIQWVVGHLPRSELDDLDSNQVAEEA 89 Query: 131 WTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDL 190 + +VR S D VLS G + V+ + +T+ Sbjct: 90 PSAIVRVRSSHIIDHVLSEARTYTCVGRTGSKTIYASTVVHPPRSSRLTPEKTYPGAQK- 148 Query: 191 VEHFKKTGIEEASGAFVYLRQPYYATRVNAAD 222 + E + + RV+A Sbjct: 149 ----PRIIYTEKTHLDLMGSNIQLPCRVHARP 176 >4MBB-A nrPDB Length = 184 Score = 31.6 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 16/63 (25%), Positives = 26/63 (41%), Gaps = 6/63 (9%) Query: 420 HGVPSEPGGVLSFLDQINQRQESLPHAGPII-VHCSAGIGRTGTIIVIDMLMENISTKGL 478 H VP + + F +N + +I VH + G+ RTG +I I +G+ Sbjct: 96 HQVPDDET-IFKFKHAVNGFLKENKDNDKLIGVHSTHGLNRTGYLI----CRYLIDVEGV 150 Query: 479 DCD 481 D Sbjct: 151 RPD 153 >3LJ8-A nrPDB Length = 146 Score = 31.2 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 27/61 (44%), Gaps = 7/61 (11%) Query: 412 YQYLSWP--DHGVPSEPGGVLSFLDQINQRQ-ESLPHAGPIIVHCSAGIGRTGTIIVIDM 468 + Y P DH + F + + E+L ++VHC AG+ R+ T+ V + Sbjct: 49 FHYKQIPISDH----WSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYL 104 Query: 469 L 469 + Sbjct: 105 M 105 >4NMN-A nrPDB Length = 434 Score = 31.2 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 30/74 (40%), Gaps = 2/74 (2%) Query: 185 DSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIE--NRVLELNKKQESEDTAKA 242 D L + + IE+ + ++L +P Y T+ + + V+ ++Q D K Sbjct: 361 DKRPQLADLRESGQIEQDADLILFLHRPEYYTKKPNPEEQGIAEVIIAKQRQGPTDIVKL 420 Query: 243 GFWEEFESLQKQEV 256 F +E+ E Sbjct: 421 AFIKEYTKFANLEA 434 >1YZ4-A nrPDB Length = 160 Score = 31.2 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 17/68 (25%), Positives = 27/68 (39%), Gaps = 2/68 (2%) Query: 403 GDLIREIWH-YQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTG 461 + + + YL P P P F + IN + G +VH AGI R+ Sbjct: 41 HESPQPLLQDITYLRIPVADTPEVPIKK-HFKECINFIHCCRLNGGNCLVHSFAGISRST 99 Query: 462 TIIVIDML 469 TI+ ++ Sbjct: 100 TIVTAYVM 107 >5GQY-A nrPDB Length = 793 Score = 30.8 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 37/112 (33%), Gaps = 16/112 (14%) Query: 47 DQVTHIRIQNSGDF-------YDLYGGEKFATLTELVEY---YTQQQGVLQDRDGTIIHL 96 V I+NS Y Y + T + +V+ Y ++ L Sbjct: 208 GTVYKYEIKNSEGHIYEKSDPYGFYREVRPNTASIVVDIDNIYQWHDEEWLEKRRNSDPL 267 Query: 97 KYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLS 148 K P++ + W HG AE + GE +V S PG LS Sbjct: 268 KQPVSVYEVHLGSWLHG----SSAEKMPLLNGEADPVIV--SEWNPGARFLS 313 >1Z6T-A nrPDB Length = 591 Score = 30.4 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 23/56 (41%), Gaps = 4/56 (7%) Query: 409 IWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLP----HAGPIIVHCSAGIGRT 460 I Y + GVP P ++ +N Q+ L G + +H AG G++ Sbjct: 106 ITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKS 161 >6E3B-A nrPDB Length = 169 Score = 30.4 bits (67), Expect = 2.4, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 18/43 (41%), Gaps = 3/43 (6%) Query: 444 PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQK 486 P PI++H + G RTG +I + + L D + Sbjct: 93 PANQPILIHSNRGKHRTGCLIG---CIRKLQNWSLTMIFDEYR 132 >6I28-A nrPDB Length = 168 Score = 30.0 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 8/23 (34%), Positives = 15/23 (65%), Gaps = 1/23 (4%) Query: 449 IIVHCSAGIGRTGTIIVIDMLME 471 +++HC AG+ R+ T+ I +M Sbjct: 100 VLIHCHAGVSRSATL-AIYYIMR 121 >1LW3-A nrPDB Length = 657 Score = 30.0 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 34/79 (43%), Gaps = 7/79 (8%) Query: 392 LRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIV 451 LR L+ N + + + + W +H +L+ +I + ES + ++V Sbjct: 366 LRKLKEIVYPNIEETHWLSNLESTHWLEH-----IKLILAGALRIADKVESGKTS--VVV 418 Query: 452 HCSAGIGRTGTIIVIDMLM 470 H S G RT + + MLM Sbjct: 419 HSSDGWDRTAQLTSLAMLM 437 >1WRM-A nrPDB Length = 165 Score = 29.6 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 11/40 (27%), Positives = 22/40 (55%), Gaps = 6/40 (15%) Query: 430 LSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 469 + F+ + R ES +VHC AG+ R+ T+++ ++ Sbjct: 73 IKFIHECRLRGESC------LVHCLAGVSRSVTLVIAYIM 106 >4KYQ-A nrPDB Length = 208 Score = 29.6 bits (65), Expect = 4.0, Method: Composition-based stats. Identities = 9/15 (60%), Positives = 11/15 (73%) Query: 445 HAGPIIVHCSAGIGR 459 G + VHCSAG+GR Sbjct: 111 GKGRVYVHCSAGLGR 125 >2G2B-A nrPDB Length = 150 Score = 29.6 bits (65), Expect = 4.1, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 13/28 (46%) Query: 333 NDFWQMAWQENSRVIVMTTREVEKGRNK 360 DF +M + S ++ M EK R K Sbjct: 107 PDFLRMMLGKRSAILKMILMYEEKAREK 134 >1I9T-A nrPDB Length = 210 Score = 29.6 bits (65), Expect = 4.1, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 17/36 (47%), Gaps = 1/36 (2%) Query: 431 SFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVI 466 +F+ + E P I VHC+ G RTG +I Sbjct: 105 TFIRLCERFNERSPPEL-IGVHCTHGFNRTGFLICA 139 >2C46-A nrPDB Length = 241 Score = 29.2 bits (64), Expect = 5.2, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 17/36 (47%), Gaps = 1/36 (2%) Query: 431 SFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVI 466 +F+ + E P I VHC+ G RTG +I Sbjct: 127 TFIRLCERFNERNPPEL-IGVHCTHGFNRTGFLICA 161 >4MHZ-A nrPDB Length = 326 Score = 28.5 bits (62), Expect = 8.0, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 17/51 (33%), Gaps = 3/51 (5%) Query: 365 WPEVGMQRAYGPYS-VTNCGEHDTTEY--KLRTLQVSPLDNGDLIREIWHY 412 WP A+ + E D ++ LR V + RE+ + Sbjct: 3 WPRDLRPLAHHDLLYMGQISEEDRGDFNATLRNFLVPRVVGSQKHREVREF 53 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.135 0.415 Lambda K H 0.267 0.0416 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,044,921 Number of Sequences: 36641 Number of extensions: 981888 Number of successful extensions: 4102 Number of sequences better than 10.0: 162 Number of HSP's better than 10.0 without gapping: 213 Number of HSP's successfully gapped in prelim test: 75 Number of HSP's that attempted gapping in prelim test: 3038 Number of HSP's gapped (non-prelim): 436 length of query: 595 length of database: 10,336,785 effective HSP length: 103 effective length of query: 492 effective length of database: 6,562,762 effective search space: 3228878904 effective search space used: 3228878904 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 62 (28.5 bits)