BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P29274 (412 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6GDG-A nrPDB 634 0.0 3PWH-A nrPDB 627 e-180 5UVI-A nrPDB 424 e-119 5WF6-A nrPDB 421 e-118 5N2S-A nrPDB 282 2e-76 6D9H-R nrPDB 271 4e-73 5UEN-A nrPDB 199 2e-51 6IBL-A nrPDB 149 3e-36 2VT4-A nrPDB 145 3e-35 3SN6-R nrPDB 127 7e-30 4LDO-A nrPDB 126 1e-29 4GBR-A nrPDB 126 2e-29 2R4S-A nrPDB 124 7e-29 6G79-S nrPDB 103 1e-22 4MQS-A nrPDB 103 1e-22 6CM4-A nrPDB 93 2e-19 3P0G-A nrPDB 91 7e-19 3RZE-A nrPDB 89 4e-18 5WS3-A nrPDB 80 1e-15 4U15-A nrPDB 80 2e-15 3PBL-A nrPDB 79 3e-15 6A94-A nrPDB 78 7e-15 4U14-A nrPDB 77 1e-14 6N4B-R nrPDB 76 2e-14 5V54-A nrPDB 76 3e-14 5DHG-A nrPDB 75 6e-14 6BQH-A nrPDB 74 9e-14 4IAR-A nrPDB 74 1e-13 4ZJC-A nrPDB 74 1e-13 2KS9-A nrPDB 74 2e-13 6B73-A nrPDB 73 3e-13 6DRY-A nrPDB 72 5e-13 5ZBQ-A nrPDB 72 5e-13 5DSG-A nrPDB 72 5e-13 4RWA-A nrPDB 70 2e-12 5CXV-A nrPDB 70 2e-12 5ZKB-A nrPDB 69 5e-12 3UON-A nrPDB 67 1e-11 5DYS-A nrPDB 65 6e-11 6DDF-R nrPDB 65 7e-11 3V2Y-A nrPDB 64 1e-10 5WIV-A nrPDB 62 3e-10 5ZTY-A nrPDB 61 1e-09 5U09-A nrPDB 60 2e-09 5C1M-A nrPDB 59 5e-09 5XRA-A nrPDB 58 8e-09 3AYN-A nrPDB 57 1e-08 4WW3-A nrPDB 57 2e-08 5W0P-A nrPDB 56 3e-08 6CMO-R nrPDB 54 1e-07 4EJ4-A nrPDB 53 2e-07 4ZUD-A nrPDB 53 3e-07 6ME9-A nrPDB 52 4e-07 6J20-A nrPDB 52 5e-07 4DKL-A nrPDB 52 6e-07 4DJH-A nrPDB 51 8e-07 4XEE-A nrPDB 51 8e-07 4BWB-A nrPDB 51 1e-06 4Z36-A nrPDB 50 1e-06 5VBL-B nrPDB 48 8e-06 4BUO-A nrPDB 48 8e-06 5ZBH-A nrPDB 45 4e-05 6HLP-A nrPDB 44 1e-04 5XJM-A nrPDB 43 2e-04 5GLH-A nrPDB 43 2e-04 5UNF-A nrPDB 43 3e-04 5GLI-A nrPDB 43 3e-04 5XSZ-A nrPDB 40 0.002 6DO1-A nrPDB 40 0.003 6AK3-B nrPDB 38 0.008 2LNL-A nrPDB 37 0.015 6M9T-A nrPDB 36 0.029 4GRV-A nrPDB 36 0.029 5NJ6-A nrPDB 35 0.049 5NDD-A nrPDB 35 0.061 4XNV-A nrPDB 35 0.068 5UIW-A nrPDB 34 0.13 3OE9-A nrPDB 34 0.15 5LWE-A nrPDB 33 0.19 5WB1-A nrPDB 33 0.19 5X33-A nrPDB 32 0.40 6AKX-A nrPDB 32 0.40 5T1A-A nrPDB 32 0.43 4XT3-A nrPDB 32 0.70 4NTJ-A nrPDB 31 1.00 5ZKP-A nrPDB 31 1.1 3VW7-A nrPDB 31 1.3 4TW5-A nrPDB 30 1.4 6GPS-A nrPDB 30 2.1 3KLY-A nrPDB 30 2.3 5ZKQ-A nrPDB 29 4.0 6D26-A nrPDB 29 4.1 3NM7-A nrPDB 28 5.5 1D0M-A nrPDB 28 6.7 6C1Q-B nrPDB 28 9.8 >6GDG-A nrPDB Length = 479 Score = 634 bits (1636), Expect = 0.0, Method: Compositional matrix adjust. Identities = 308/312 (98%), Positives = 309/312 (99%) Query: 5 GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI 64 +VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI Sbjct: 168 AKAVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI 227 Query: 65 TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 124 TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI Sbjct: 228 TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 287 Query: 125 IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 IAICWVLSFAIGLTPMLGWNNCGQPKEGK HSQGCGEGQVACLFEDVVPMNYMVYFNFFA Sbjct: 288 IAICWVLSFAIGLTPMLGWNNCGQPKEGKAHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 347 Query: 185 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL 244 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL Sbjct: 348 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL 407 Query: 245 CWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 CWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR Sbjct: 408 CWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 467 Query: 305 SHVLRQQEPFKA 316 SHVLRQQEPFKA Sbjct: 468 SHVLRQQEPFKA 479 >3PWH-A nrPDB Length = 329 Score = 627 bits (1616), Expect = e-180, Method: Compositional matrix adjust. Identities = 307/315 (97%), Positives = 308/315 (97%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADI VGVLAI Sbjct: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADILVGVLAI 60 Query: 61 PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR 120 PFAITISTGFCAACHGCLFIACFVLVL QSSIFSLLAIAIDRYIAI IPLRYNGLVTGTR Sbjct: 61 PFAITISTGFCAACHGCLFIACFVLVLAQSSIFSLLAIAIDRYIAIAIPLRYNGLVTGTR 120 Query: 121 AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180 A GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF Sbjct: 121 AAGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180 Query: 181 NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG 240 NFFACVLVPLLLMLGVYLRIF AARRQLKQMESQPLPGERARSTLQKEVHAAKS AII G Sbjct: 181 NFFACVLVPLLLMLGVYLRIFAAARRQLKQMESQPLPGERARSTLQKEVHAAKSAAIIAG 240 Query: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVL+HTNSVVNPFIYAYRIREFRQTFR Sbjct: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLAHTNSVVNPFIYAYRIREFRQTFR 300 Query: 301 KIIRSHVLRQQEPFK 315 KIIRSHVLRQQEPFK Sbjct: 301 KIIRSHVLRQQEPFK 315 >5UVI-A nrPDB Length = 447 Score = 424 bits (1091), Expect = e-119, Method: Compositional matrix adjust. Identities = 211/232 (90%), Positives = 216/232 (93%) Query: 2 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 61 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP Sbjct: 27 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 86 Query: 62 FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 121 FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA Sbjct: 87 FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 146 Query: 122 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN Sbjct: 147 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 206 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAK 233 FFACVLVPLLLMLGVYLRIFLAARRQL +E ++K +AA+ Sbjct: 207 FFACVLVPLLLMLGVYLRIFLAARRQLADLEDNWETLNDNLKVIEKADNAAQ 258 Score = 213 bits (542), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 103/116 (88%), Positives = 105/116 (90%), Gaps = 2/116 (1%) Query: 203 AARRQLKQMESQPLPG--ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP 260 AA QLK + + ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP Sbjct: 322 AAAEQLKTTRNAYIQKYLERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP 381 Query: 261 DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 316 DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA Sbjct: 382 DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 437 >5WF6-A nrPDB Length = 504 Score = 421 bits (1081), Expect = e-118, Method: Compositional matrix adjust. Identities = 211/236 (89%), Positives = 217/236 (91%), Gaps = 1/236 (0%) Query: 2 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 61 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP Sbjct: 33 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 92 Query: 62 FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 121 FAITISTGFCAACHGCLFIACFVLVLTQS+IFSLLAIAIDRYIAIRIPLRYNGLVTGTRA Sbjct: 93 FAITISTGFCAACHGCLFIACFVLVLTQSAIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 152 Query: 122 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN Sbjct: 153 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 212 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 FFACVLVPLLLMLGVYLRIFLAARRQL E + E R + K+ ++ I Sbjct: 213 FFACVLVPLLLMLGVYLRIFLAARRQLNIFEMLRI-DEGLRLKIYKDTEGYYTIGI 267 Score = 205 bits (521), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 95/95 (100%), Positives = 95/95 (100%) Query: 222 RSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNS 281 RSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNS Sbjct: 400 RSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNS 459 Query: 282 VVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 316 VVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA Sbjct: 460 VVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 494 >5N2S-A nrPDB Length = 436 Score = 282 bits (721), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 155/308 (50%), Positives = 198/308 (64%), Gaps = 3/308 (0%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT 65 + YI +E+ IA++++ GNVLV WAV +N L++ T F+VSLA AD+ VG L IP AI Sbjct: 116 QAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVLVGALVIPLAIL 175 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 I+ G H CL +AC VL+L QSSI +LLAIA+DRY+ ++IPLRY +VT RA I Sbjct: 176 INIGPQTYFHTCLMVACPVLILAQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAI 235 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 A CW+LSF +GLTPM GWNN + + GE + C FE V+ M YMVYFNFF Sbjct: 236 AGCWILSFVVGLTPMFGWNNLSAVERAWAAAGSMGEPVIKCEFEKVISMEYMVYFNFFVW 295 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 245 VL PLLLM+ +YL +F R+QL + S + KE+ AKS A+I LFAL Sbjct: 296 VLPPLLLMVLIYLEVFALIRKQLNKKVSA--SSGDPQKYYGKELKIAKSAALIAFLFALS 353 Query: 246 WLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 WLPLHI+NC T FCP C H P L Y+AI L+H NS +NP +YA+RI++FR TF KI Sbjct: 354 WLPLHILNCITLFCPSC-HKPSILTYIAIFLAHGNSAMNPIVYAFRIQKFRVTFLKIWND 412 Query: 306 HVLRQQEP 313 H Q P Sbjct: 413 HFRSQPAP 420 >6D9H-R nrPDB Length = 389 Score = 271 bits (692), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 158/307 (51%), Positives = 202/307 (65%), Gaps = 3/307 (0%) Query: 7 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI 66 + YI +E+ IA++++ GNVLV WAV +N L++ T F+VSLA AD+AVG L IP AI I Sbjct: 65 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILI 124 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + G H CL +AC VL+LTQSSI +LLAIA+DRY+ ++IPLRY +VT RA IA Sbjct: 125 NIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIA 184 Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186 CW+LSF +GLTPM GWNN + + GE + C FE V+ M YMVYFNFF V Sbjct: 185 GCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWV 244 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCW 246 L PLLLM+ +YL +F R+QL + S + KE+ AKSLA+I+ LFAL W Sbjct: 245 LPPLLLMVLIYLEVFYLIRKQLNKKVSA--SSGDPQKYYGKELKIAKSLALILFLFALSW 302 Query: 247 LPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH 306 LPLHI+NC T FCP C H P L Y+AI L+H NS +NP +YA+RI++FR TF KI H Sbjct: 303 LPLHILNCITLFCPSC-HKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDH 361 Query: 307 VLRQQEP 313 Q P Sbjct: 362 FRCQPAP 368 >5UEN-A nrPDB Length = 416 Score = 199 bits (506), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 108/209 (51%), Positives = 140/209 (66%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT 65 + YI +E+ IA++++ GNVLV WAV +N L++ T F+VSLA AD+AVG L IP AI Sbjct: 10 QAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL 69 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 I+ G H CL +AC VL+LTQSSI +LLAIA+DRY+ ++IPLRY +VT RA I Sbjct: 70 INIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAI 129 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 A CW+LSF +GLTPM GWNN + + GE + C FE V+ M YMVYFNFF Sbjct: 130 AGCWILSFVVGLTPMFGWNNLSAVERAWAAAGSMGEPVIKCEFEKVISMEYMVYFNFFVW 189 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQ 214 VL PLLLM+ +YL +F R+QL +E Sbjct: 190 VLPPLLLMVLIYLEVFYLIRKQLADLEDN 218 Score = 105 bits (261), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 61/106 (57%), Positives = 74/106 (69%), Gaps = 3/106 (2%) Query: 203 AARRQLKQMESQPLPG--ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP 260 AA QLK + + ERARSTLQKE+ AKSLA+I+ LFAL WLPLHI+NC T FCP Sbjct: 301 AAAEQLKTTRNAYIQKYLERARSTLQKELKIAKSLALILFLFALSWLPLHILNCITLFCP 360 Query: 261 DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH 306 C H P L Y+AI L+H NS +NP +YA+RI++FR TF KI H Sbjct: 361 SC-HKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDH 405 >6IBL-A nrPDB Length = 416 Score = 149 bits (375), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 104/293 (35%), Positives = 156/293 (53%), Gaps = 19/293 (6%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI---STGFCA 72 + +L + GNVLV A+ LQ +TN F+ SLA AD+ VG+L +PF T+ T Sbjct: 122 VVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWG 181 Query: 73 ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132 + L+ + VL +T +SI +L IAIDRY+AI P RY L+T RAK II W +S Sbjct: 182 SFLCELWTSLDVLCVT-ASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAIS 240 Query: 133 FAIGLTP-MLGWNNCGQPKEGKNHSQ-GCGEGQVACLFEDVVPMNYMVYFNFFACVLVPL 190 + P M+ W P+ K + GC C F V Y + + + +PL Sbjct: 241 ALVSFLPIMMHWWRDEDPQALKCYQDPGC------CDF--VTNRAYAIASSIIS-FYIPL 291 Query: 191 LLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLH 250 L+M+ VYLR++ A+ Q+++++ + +R KE A K+L II+G+F LCWLP Sbjct: 292 LIMIFVYLRVYREAKEQIRKIDRAS-KRKTSRVMAMKEHKALKTLGIIMGVFTLCWLPFF 350 Query: 251 IINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 ++N F D P WL L + NS +NP IY R +FR+ F++++ Sbjct: 351 LVNIVNVFNRDL--VPDWLFVAFNWLGYANSAMNPIIYC-RSPDFRKAFKRLL 400 >2VT4-A nrPDB Length = 313 Score = 145 bits (366), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 107/300 (35%), Positives = 162/300 (54%), Gaps = 22/300 (7%) Query: 10 ITVELAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI-- 66 +++ +A+ VL I+ GNVLV A+ LQ +TN F+ SLA AD+ VG+L +PF T+ Sbjct: 14 MSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVV 73 Query: 67 -STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 T + L+ + VL +T +SI +L IAIDRY+AI P RY L+T RAK II Sbjct: 74 RGTWLWGSFLCELWTSLDVLCVT-ASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVII 132 Query: 126 AICWVLSFAIGLTP-MLGWNNCGQPKEGKNHSQ-GCGEGQVACLFEDVVPMNYMVYFNFF 183 W +S + P M+ W P+ K + GC C F V Y + + Sbjct: 133 CTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGC------CDF--VTNRAYAIASSII 184 Query: 184 ACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFA 243 + +PLL+M+ V LR++ A+ Q+++++ +R R L +E A K+L II+G+F Sbjct: 185 S-FYIPLLIMIFVALRVYREAKEQIRKIDR---ASKRKRVMLMREHKALKTLGIIMGVFT 240 Query: 244 LCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 LCWLP ++N F D P WL L + NS +NP IY R +FR+ F++++ Sbjct: 241 LCWLPFFLVNIVNVFNRDL--VPDWLFVAFNWLGYANSAMNPIIYC-RSPDFRKAFKRLL 297 >3SN6-R nrPDB Length = 514 Score = 127 bits (320), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 105/342 (30%), Positives = 166/342 (48%), Gaps = 40/342 (11%) Query: 14 LAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITISTGF 70 +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A ++ + Sbjct: 189 MSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTW 248 Query: 71 CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWV 130 C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II + W+ Sbjct: 249 TFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWI 308 Query: 131 LSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189 +S P+ + W + + C + C F Y + + + VP Sbjct: 309 VSGLTSFLPIQMHW-----YRATHQEAINCYAEETCCDF--FTNQAYAIASSIVS-FYVP 360 Query: 190 LLLMLGVYLRIFLAARRQLK---------------QMESQPLPGERARSTLQ---KEVHA 231 L++M+ VY R+F A+RQL+ Q+E G R + + KE A Sbjct: 361 LVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKA 420 Query: 232 AKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYR 291 K+L II+G F LCWLP I+N + ++++ I + NS NP IY R Sbjct: 421 LKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWI--GYVNSGFNPLIYC-R 477 Query: 292 IREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQ 333 +FR F++++ LR + KA G +++G+ GEQ Sbjct: 478 SPDFRIAFQELL---CLR-RSSLKAYGNG---YSSNGNTGEQ 512 >4LDO-A nrPDB Length = 469 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 92/294 (31%), Positives = 146/294 (49%), Gaps = 25/294 (8%) Query: 14 LAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITISTGF 70 +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A ++ + Sbjct: 189 MSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTW 248 Query: 71 CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWV 130 C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II + W+ Sbjct: 249 TFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWI 308 Query: 131 LSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189 +S P+ + W + + C + C D + VP Sbjct: 309 VSGLTSFLPIQMHW-----YRATHQEAINCYAEETCC---DFFTNQAYAIASSIVSFYVP 360 Query: 190 LLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPL 249 L++M+ VY R+F A+RQL++++ L KE A K+L II+G F LCWLP Sbjct: 361 LVIMVFVYSRVFQEAKRQLQKIDKFAL----------KEHKALKTLGIIMGTFTLCWLPF 410 Query: 250 HIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 I+N + ++++ I + NS NP IY R +FR F++++ Sbjct: 411 FIVNIVHVIQDNLIRKEVYILLNWI--GYVNSGFNPLIYC-RSPDFRIAFQELL 461 >4GBR-A nrPDB Length = 309 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 101/326 (30%), Positives = 161/326 (49%), Gaps = 32/326 (9%) Query: 12 VELAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITIST 68 + +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A ++ Sbjct: 10 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTK 69 Query: 69 GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II + Sbjct: 70 TWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMV 129 Query: 129 WVLSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL 187 W++S P+ + W + + C + C D + Sbjct: 130 WIVSGLTSFLPIQMHW-----YRATHQEAINCYAEETCC---DFFTNQAYAIASSIVSFY 181 Query: 188 VPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWL 247 VPL++M+ VY R+F A+RQL++++ L KE A K+L II+G F LCWL Sbjct: 182 VPLVIMVFVYSRVFQEAKRQLQKIDKFCL----------KEHKALKTLGIIMGTFTLCWL 231 Query: 248 PLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHV 307 P I+N + ++++ I + NS NP IY R +FR F++++ Sbjct: 232 PFFIVNIVHVIQDNLIRKEVYILLNWI--GYVNSGFNPLIYC-RSPDFRIAFQELL---C 285 Query: 308 LRQQEPFKAAGTSARVLAAHGSDGEQ 333 LR + KA G +++G+ GEQ Sbjct: 286 LR-RSSLKAYGNG---YSSNGNTGEQ 307 >2R4S-A nrPDB Length = 342 Score = 124 bits (312), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 104/342 (30%), Positives = 162/342 (47%), Gaps = 40/342 (11%) Query: 14 LAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITISTGF 70 +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A + + Sbjct: 17 MSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMW 76 Query: 71 CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWV 130 C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II + W+ Sbjct: 77 TFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWI 136 Query: 131 LSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189 +S P+ + W + + C + C D + VP Sbjct: 137 VSGLTSFLPIQMHW-----YRATHQEAINCYANETCC---DFFTNQAYAIASSIVSFYVP 188 Query: 190 LLLMLGVYLRIFLAARRQLK---------------QMESQPLPGERARSTLQ---KEVHA 231 L++M+ VY R+F A+RQL+ Q+E G R + + KE A Sbjct: 189 LVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKA 248 Query: 232 AKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYR 291 K+L II+G F LCWLP I+N + ++++ I + NS NP IY R Sbjct: 249 LKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWI--GYVNSGFNPLIYC-R 305 Query: 292 IREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQ 333 +FR F++++ LR + KA G +++G+ GEQ Sbjct: 306 SPDFRIAFQELL---CLR-RSSLKAYGNG---YSSNGNTGEQ 340 >6G79-S nrPDB Length = 364 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 97/353 (27%), Positives = 147/353 (41%), Gaps = 71/353 (20%) Query: 7 SVYITVELAIAVLAI-LGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI- 64 V + + LA+ LA L N V V+ L NY + SLA D+ V +L +P + Sbjct: 17 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 76 Query: 65 -TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 T++ + C F + +SI+ L IA+DRY AI + Y+ T RA Sbjct: 77 YTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAV 136 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY--FN 181 +IA+ WV S +I L P W Q E +V+ E VV ++++Y ++ Sbjct: 137 MIALVWVFSISISLPPFF-WR------------QAKAEEEVS---ECVVNTDHILYTVYS 180 Query: 182 FFACVLVPLLLMLGVYLRIFLAAR-RQLKQMESQ------------PLPG---------- 218 P LL++ +Y RI++ AR R LKQ ++ PG Sbjct: 181 TVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINS 240 Query: 219 ---------------------------ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHI 251 E+ + +E A K+L II+G F +CWLP I Sbjct: 241 RVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFI 300 Query: 252 INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 I+ C D L + L + NS++NP IY +F+Q F K+IR Sbjct: 301 ISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIR 353 >4MQS-A nrPDB Length = 351 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 79/306 (25%), Positives = 145/306 (47%), Gaps = 33/306 (10%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAAC 74 +++++ I+GN+LV ++ +N +LQ V NYF+ SLA AD+ +GV F++ + T + Sbjct: 49 SLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGV----FSMNLYTLYTVIG 104 Query: 75 HG------CLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C V++ +S+ +LL I+ DRY + PL Y T A +IA Sbjct: 105 YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAA 164 Query: 129 WVLSFAIGLTPMLGWN---NCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 WVLSF + +L W ++G+ + Q V F + Y+ Sbjct: 165 WVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVT--FGTAIAAFYL-------- 214 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQK-----EVHAAKSLAIIVG 240 P+++M +Y I A++ ++K+ + +P+ + ST +K E +++ I+ Sbjct: 215 ---PVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSTRKKPPPSREKKVTRTILAILL 271 Query: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300 F + W P +++ FC C +W + L + NS +NP YA F++TF+ Sbjct: 272 AFIITWAPYNVMVLINTFCAPCIPNTVWT--IGYWLCYINSTINPACYALCNATFKKTFK 329 Query: 301 KIIRSH 306 ++ H Sbjct: 330 HLLMCH 335 >6CM4-A nrPDB Length = 430 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 67/201 (33%), Positives = 105/201 (52%), Gaps = 25/201 (12%) Query: 14 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI---TISTGF 70 L IAV+ + GNVLVC AV LQ TNY +VSLA AD+ V L +P+ + + Sbjct: 9 LLIAVI-VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWK 67 Query: 71 CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI-IAICW 129 + H +F+ V++ T S++ +L AI+IDRY A+ +P+ YN + R + I+I W Sbjct: 68 FSRIHCDIFVTLDVMMCTASAL-NLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVW 126 Query: 130 VLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189 VLSF I + G NN Q + C+ + + Y +F+ VP Sbjct: 127 VLSFTISCPLLFGLNNADQNE---------------CIIANPAFVVYSSIVSFY----VP 167 Query: 190 LLLMLGVYLRIFLAARRQLKQ 210 ++ L VY++I++ RR+ K+ Sbjct: 168 FIVTLLVYIKIYIVLRRRRKR 188 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 33/79 (41%), Positives = 44/79 (55%), Gaps = 4/79 (5%) Query: 226 QKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIV-LSHTNSVVN 284 QKE A + AI+ G+F +CWLP I + C DC+ P ++Y A L + NS VN Sbjct: 353 QKEKKATQMAAIVAGVFIICWLPFFITHILNIHC-DCNIPP--VLYSAFTWLGYVNSAVN 409 Query: 285 PFIYAYRIREFRQTFRKII 303 P IY EFR+ F KI+ Sbjct: 410 PIIYTTFNIEFRKAFLKIL 428 >3P0G-A nrPDB Length = 501 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 72/228 (31%), Positives = 113/228 (49%), Gaps = 13/228 (5%) Query: 14 LAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITISTGF 70 +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A + + Sbjct: 48 MSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMW 107 Query: 71 CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWV 130 C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II + W+ Sbjct: 108 TFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWI 167 Query: 131 LSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189 +S P+ + W +E N C + C F Y + + + VP Sbjct: 168 VSGLTSFLPIQMHWYRATH-QEAIN----CYAEETCCDF--FTNQAYAIASSIVS-FYVP 219 Query: 190 LLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 L++M+ VY R+F A+RQL E + E R + K+ ++ I Sbjct: 220 LVIMVFVYSRVFQEAKRQLNIFEMLRID-EGLRLKIYKDTEGYYTIGI 266 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/107 (33%), Positives = 55/107 (51%), Gaps = 10/107 (9%) Query: 227 KEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPF 286 KE A K+L II+G F LCWLP I+N + ++++ I + NS NP Sbjct: 403 KEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWI--GYVNSGFNPL 460 Query: 287 IYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQ 333 IY R +FR F++++ LR + KA G +++G+ GEQ Sbjct: 461 IYC-RSPDFRIAFQELL---CLR-RSSLKAYGNG---YSSNGNTGEQ 499 >3RZE-A nrPDB Length = 452 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 73/232 (31%), Positives = 110/232 (47%), Gaps = 16/232 (6%) Query: 10 ITVELAIAVLAILG-NVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--I 66 + V L+ L +G N+LV +AV L V N ++VSL+ AD+ VG + +P I + Sbjct: 11 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 70 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + + CLF V + +SIFS+ + IDRY +++ PLRY T TRA I Sbjct: 71 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 130 Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMV-YFNFFAC 185 W LSF + + P+LGWN+ Q + E + F DV M NF+ Sbjct: 131 GAWFLSF-LWVIPILGWNHFMQQTSVRR------EDKCETDFYDVTWFKVMTAIINFY-- 181 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 +P LLML Y +I+ A R+ E + E R + K+ ++ I Sbjct: 182 --LPTLLMLWFYAKIYKAVRQHCNIFEMLRI-DEGLRLKIYKDTEGYYTIGI 230 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 42/79 (53%), Gaps = 2/79 (2%) Query: 225 LQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVN 284 + +E AAK L I+ F LCW+P I FC +C + L + I L + NS +N Sbjct: 365 MNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHM--FTIWLGYINSTLN 422 Query: 285 PFIYAYRIREFRQTFRKII 303 P IY F++TF++I+ Sbjct: 423 PLIYPLCNENFKKTFKRIL 441 >5WS3-A nrPDB Length = 560 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 62/194 (31%), Positives = 95/194 (48%), Gaps = 14/194 (7%) Query: 14 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAITISTGFC 71 + + V+A++GNVLVC AVW N +++ VTNYF+V+L+ AD+ V + +P + I+ + Sbjct: 69 IIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWF 128 Query: 72 AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVL 131 C I V S+ +L IA+DR+ AI PL + T RA+ I I W++ Sbjct: 129 FGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARNSIVIIWIV 186 Query: 132 SFAIGLTPMLGWNNCGQPKEGKNHSQG----CGEGQVACLFEDVVPMNYMVYFNFFACVL 187 S I + P C G + C E ++ P Y + F F + Sbjct: 187 S-CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGG----EIYPKMYHICF-FLVTYM 240 Query: 188 VPLLLMLGVYLRIF 201 PL LM+ YL+IF Sbjct: 241 APLCLMVLAYLQIF 254 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 12/92 (13%) Query: 219 ERARSTLQKEVHA----AKSLAIIVGLFALCWLPLHIIN----CFTFF--CPDCSHAPLW 268 +RA S K++ A A+ L +++ +FA+C+LP+ I+N F F D W Sbjct: 451 KRAMS-FSKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAW 509 Query: 269 LMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300 + + L + NS NP IY + +FR+ F+ Sbjct: 510 FTF-SHWLVYANSAANPIIYNFLSGKFREEFK 540 >4U15-A nrPDB Length = 418 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/243 (28%), Positives = 114/243 (46%), Gaps = 22/243 (9%) Query: 2 PIMGSSVYITVELA-----IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVG 56 P+ G +++ V +A +A++ I+GN+LV A +N L+ V NYF++SLA AD+ +G Sbjct: 3 PLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIG 62 Query: 57 VLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNG 114 V+++ T I + C V + +S+ +LL I+ DRY +I PL Y Sbjct: 63 VISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRA 122 Query: 115 LVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPM 174 T RA +I + WV+SF + +L W Q GK + GE + L E + Sbjct: 123 KRTTKRAGVMIGLAWVISFVLWAPAILFW----QYFVGK-RTVPPGECFIQFLSEPTITF 177 Query: 175 NYMVYFNFFACVLVPLLLMLGVYLRIFLAARR-----QLKQMESQPLPGERARSTLQKEV 229 + A +P+ +M +Y RI+ + L+ E G+ A ++V Sbjct: 178 GTAI-----AAFYMPVTIMTILYWRIYKETEKMNIFEMLRIDEGGGSGGDEAEKLFNQDV 232 Query: 230 HAA 232 AA Sbjct: 233 DAA 235 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 40/79 (50%), Gaps = 2/79 (2%) Query: 225 LQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVN 284 L KE AA++L+ I+ F + W P +I+ FC C W L L + NS VN Sbjct: 323 LIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYW--NLGYWLCYINSTVN 380 Query: 285 PFIYAYRIREFRQTFRKII 303 P YA + FR TF+ ++ Sbjct: 381 PVCYALCNKTFRTTFKTLL 399 >3PBL-A nrPDB Length = 481 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 50/143 (34%), Positives = 74/143 (51%), Gaps = 10/143 (6%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST-----G 69 A+ + + GN LVC AV LQ TNY VVSLA AD+ V L +P+ + + Sbjct: 47 ALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 106 Query: 70 FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRY---NGLVTGTRAKGIIA 126 F C C +++ +SI++L AI+IDRY A+ +P+ Y G + R +I Sbjct: 107 FSRIC--CDVFVTLDVMMCTASIWNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMIT 164 Query: 127 ICWVLSFAIGLTPMLGWNNCGQP 149 WVL+FA+ + G+N G P Sbjct: 165 AVWVLAFAVSCPLLFGFNTTGDP 187 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 28/78 (35%), Positives = 42/78 (53%), Gaps = 3/78 (3%) Query: 227 KEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIV-LSHTNSVVNP 285 +E A + +AI++G F +CWLP + + C C +P +Y A L + NS +NP Sbjct: 395 REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSP--ELYSATTWLGYVNSALNP 452 Query: 286 FIYAYRIREFRQTFRKII 303 IY EFR+ F KI+ Sbjct: 453 VIYTTFNIEFRKAFLKIL 470 >6A94-A nrPDB Length = 376 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 110/225 (48%), Gaps = 25/225 (11%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA-ITISTGF---- 70 + +L I GN+LV AV L LQN TNYF++SLA AD+ +G L +P + +TI G+ Sbjct: 18 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPL 77 Query: 71 -CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129 C +++ ++ + + I+ L AI++DRY+AI+ P+ ++ + T+A I W Sbjct: 78 PSKLCAVWIYLD---VLFSTAKIWHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVW 134 Query: 130 VLSFAIGL-TPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 +S I + P+ G ++ S+ EG +CL D + V F + Sbjct: 135 TISVGISMPIPVFGL---------QDDSKVFKEG--SCLLAD----DNFVLIGSFVSFFI 179 Query: 189 PLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAK 233 PL +M+ Y + +++ +E ++K +AA+ Sbjct: 180 PLTIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQ 224 >4U14-A nrPDB Length = 460 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 103/212 (48%), Gaps = 17/212 (8%) Query: 2 PIMGSSVYITVELA-----IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVG 56 P+ G +++ V +A +A++ I+GN+LV A +N L+ V NYF++SLA AD+ +G Sbjct: 3 PLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIG 62 Query: 57 VLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNG 114 V+++ T I + C V + +S+ +LL I+ DRY +I PL Y Sbjct: 63 VISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRA 122 Query: 115 LVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPM 174 T RA +I + WV+SF + +L W Q GK + GE + L E + Sbjct: 123 KRTTKRAGVMIGLAWVISFVLWAPAILFW----QYFVGK-RTVPPGECFIQFLSEPTITF 177 Query: 175 NYMVYFNFFACVLVPLLLMLGVYLRIFLAARR 206 + A +P+ +M +Y RI+ + Sbjct: 178 GTAI-----AAFYMPVTIMTILYWRIYKETEK 204 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 40/79 (50%), Gaps = 2/79 (2%) Query: 225 LQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVN 284 L KE AA++L+ I+ F + W P +I+ FC C W L L + NS VN Sbjct: 366 LIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYW--NLGYWLCYINSTVN 423 Query: 285 PFIYAYRIREFRQTFRKII 303 P YA + FR TF+ ++ Sbjct: 424 PVCYALCNKTFRTTFKTLL 442 >6N4B-R nrPDB Length = 495 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 89/318 (27%), Positives = 140/318 (44%), Gaps = 44/318 (13%) Query: 13 ELAIAVLA-------ILGNVLVCWAVWLNSNLQNVTNY-FVVSLAAADIAVGVLAIPFAI 64 +LAIAVL+ +L N+LV + + +L+ +Y F+ SLA AD+ V+ + I Sbjct: 131 QLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFI 190 Query: 65 TISTGFCAACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 LF V +S+ SL AIDRYI+I PL Y +VT R K Sbjct: 191 DFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVT--RPKA 248 Query: 124 IIAIC--WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 ++A C W ++ I + P+LGWN C + Q C D+ P Y Sbjct: 249 VVAFCLMWTIAIVIAVLPLLGWN--------------CEKLQSVC--SDIFPHIDETYLM 292 Query: 182 FFACVL-VPLLLMLGVYLRIFLAAR----RQLKQMESQPL---PGERARSTLQK------ 227 F+ V V LL ++ Y+ I A R +++ + + E + + + Sbjct: 293 FWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARM 352 Query: 228 EVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFI 287 ++ AK+L +I+ + +CW PL I + F + ++ L NS VNP I Sbjct: 353 DIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSM-LCLLNSTVNPII 411 Query: 288 YAYRIREFRQTFRKIIRS 305 YA R ++ R FR + S Sbjct: 412 YALRSKDLRHAFRSMFPS 429 >5V54-A nrPDB Length = 395 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 64/232 (27%), Positives = 107/232 (46%), Gaps = 21/232 (9%) Query: 7 SVYITVELAIAVLAI-LGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI- 64 V + + LA+ LA L N V V+ L NY + SLA D+ V +L +P + Sbjct: 13 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 72 Query: 65 -TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 T++ + C F + +SI+ L IA+DRY AI + Y+ T RA Sbjct: 73 YTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAV 132 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY--FN 181 +IA+ WV S +I L P W Q E +V+ E VV ++++Y ++ Sbjct: 133 MIALVWVFSISISLPPFF-WR------------QAKAEEEVS---ECVVNTDHILYTVYS 176 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAK 233 P LL++ +Y RI++ AR ++ +E + E +++ +AA+ Sbjct: 177 TVGAFYFPTLLLIALYGRIYVEARSRIADLEDRWRTLEDNLRVIERAANAAE 228 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 30/78 (38%), Positives = 42/78 (53%) Query: 227 KEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPF 286 +E A K+L II+G F +CWLP II+ C D L + L + NS++NP Sbjct: 313 RERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPI 372 Query: 287 IYAYRIREFRQTFRKIIR 304 IY +F+Q F K+IR Sbjct: 373 IYTMSNEDFKQAFHKLIR 390 >5DHG-A nrPDB Length = 424 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 76/312 (24%), Positives = 145/312 (46%), Gaps = 36/312 (11%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 +P+ + + LA+ V +LGN LV + + ++ ++ TN ++ +LA AD V +L + Sbjct: 120 LPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTL 178 Query: 61 PFAIT-ISTGF----CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGL 115 PF T I GF A C + I + + +S F+L A+++DRY+AI P+R + Sbjct: 179 PFQGTDILLGFWPFGNALCKTVIAIDYYNMF---TSTFTLTAMSVDRYVAICHPIRALDV 235 Query: 116 VTGTRAKGIIAICWVLSFAIGL-TPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPM 174 T ++A+ + W L+ +G+ ++G S + ++ CL E P Sbjct: 236 RTSSKAQAVNVAIWALASVVGVPVAIMG-------------SAQVEDEEIECLVEIPTPQ 282 Query: 175 NY----MVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVH 230 +Y F +VP+L++ Y + R+L+ + + L G R + + + Sbjct: 283 DYWGPVFAICIFLFSFIVPVLVISVCYSLMI----RRLRGV--RLLSGSREKDRNLRRI- 335 Query: 231 AAKSLAIIVGLFALCWLPLHI-INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYA 289 + + ++V +F CW P+ + + S + ++ L + NS +NP +YA Sbjct: 336 -TRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYA 394 Query: 290 YRIREFRQTFRK 301 + F+ FRK Sbjct: 395 FLDENFKACFRK 406 >6BQH-A nrPDB Length = 452 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 98/211 (46%), Gaps = 16/211 (7%) Query: 26 LVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP---FAITISTGFCAACHGCLFIAC 82 LV AV + L N TNYF++SLA AD+ VG+L +P AI + + C Sbjct: 60 LVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWIS 119 Query: 83 FVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLG 142 ++ + +SI L AI++DRY+AIR P+ ++ + T+A IAI W +S + + P+ Sbjct: 120 LDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSV-PI-- 176 Query: 143 WNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFL 202 P G + C+ D N+++ +F A +PL +M+ Y Sbjct: 177 ------PVIGLRDEEKVFVNNTTCVLNDP---NFVLIGSFVA-FFIPLTIMVITYCLTIY 226 Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAK 233 RRQ +E ++K +AA+ Sbjct: 227 VLRRQAADLEDNWETLNDNLKVIEKADNAAQ 257 >4IAR-A nrPDB Length = 401 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/232 (27%), Positives = 105/232 (45%), Gaps = 21/232 (9%) Query: 7 SVYITVELAIAVLAI-LGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI- 64 V + + LA+ LA L N V V+ L NY + SLA D+ V +L +P + Sbjct: 20 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 79 Query: 65 -TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 T++ + C F + +SI+ L IA+DRY AI + Y+ T RA Sbjct: 80 YTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAV 139 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY--FN 181 +IA+ WV S +I L P W Q E +V+ E VV ++++Y ++ Sbjct: 140 MIALVWVFSISISLPPFF-WR------------QAKAEEEVS---ECVVNTDHILYTVYS 183 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAK 233 P LL++ +Y RI++ AR ++ +E ++K +AA+ Sbjct: 184 TVGAFYFPTLLLIALYGRIYVEARSRIADLEDNWETLNDNLKVIEKADNAAQ 235 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 50/102 (49%), Gaps = 4/102 (3%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDC 262 AA QLK + + A +E A K+L II+G F +CWLP II+ C D Sbjct: 299 AAAEQLKTTRNAYIQKYLA----ARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDA 354 Query: 263 SHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 L + L + NS++NP IY +F+Q F K+IR Sbjct: 355 CWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIR 396 >4ZJC-A nrPDB Length = 553 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 61/185 (32%), Positives = 87/185 (47%), Gaps = 14/185 (7%) Query: 23 GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAITISTGFCAACHGCLFI 80 GN LVC AVW N +++ VTNYF+V+L+ AD+ V + +P + I+ + C I Sbjct: 71 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVI 130 Query: 81 ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPM 140 V ++ +L IA+DR+ AI PL + T RA+G I W +S AI + P Sbjct: 131 PYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVPQ 187 Query: 141 LGWNNCGQP-KEGKNHSQ---GCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGV 196 C E N ++ C E +D+ P Y F F L PL LM Sbjct: 188 AAVMECSSVLPELANRTRLFSVCDERWA----DDLYPKIYHSCF-FIVTYLAPLGLMAMA 242 Query: 197 YLRIF 201 Y +IF Sbjct: 243 YFQIF 247 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 35/96 (36%) Query: 225 LQKEVHAAKSLAIIVGLFALCWLPLHIIN--------------------CFTFFCPDCSH 264 ++ AK L +++ +FALC+LP+ ++N CFTF SH Sbjct: 453 MRARRKTAKMLMVVLLVFALCYLPISVLNILKRVFGMFRQASDREAVYACFTF-----SH 507 Query: 265 APLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300 WL+Y NS NP IY + +FR+ F+ Sbjct: 508 ---WLVY-------ANSAANPIIYNFLSGKFREQFK 533 >2KS9-A nrPDB Length = 364 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 80/321 (24%), Positives = 139/321 (43%), Gaps = 48/321 (14%) Query: 29 WAVWLNSNLQNVTNYFVVSLAAADIAVGVL--AIPFAITISTGFCAACHGCLFIACFVLV 86 W + + ++ VTNYF+V+LA A+ ++ + F + + C F F + Sbjct: 55 WIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIA 114 Query: 87 LTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNC 146 +SI+S+ A+A DRY+AI PL+ ++ T K +I + WVL+ + Sbjct: 115 AVFASIYSMTAVAFDRYMAIIHPLQ--PRLSATATKVVICVIWVLALLLAF--------- 163 Query: 147 GQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV-----PLLLMLGVYLRIF 201 +G + +V C+ E N + + CV V PLL++ Y + Sbjct: 164 ---PQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVG 220 Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGL----FALCWLPLHIINCFTF 257 + + + +PG+ + ++V A + + ++ + FA+CWLP HI + Sbjct: 221 IT-------LWASEIPGD-SSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPY 272 Query: 258 FCPDCSHAP-LWLMYLAIV-LSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFK 315 PD + +YLAI+ L+ ++++ NP IY FR F+ R PF Sbjct: 273 INPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCC------PFI 326 Query: 316 AAG-------TSARVLAAHGS 329 +AG S R L GS Sbjct: 327 SAGDYEGLEMKSTRYLQTQGS 347 >6B73-A nrPDB Length = 418 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 84/311 (27%), Positives = 152/311 (48%), Gaps = 37/311 (11%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 +P++ ++VY V V+ ++GN LV + + + ++ TN ++ +LA AD A+ + Sbjct: 118 IPVIITAVYSVV----FVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD-ALVTTTM 172 Query: 61 PFAITI----STGFCAA-CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGL 115 PF T+ S F C L I + + +SIF+L +++DRYIA+ P++ Sbjct: 173 PFQSTVYLMNSWPFGDVLCKIVLSIDYYNMF---TSIFTLTMMSVDRYIAVCHPVKALDF 229 Query: 116 VTGTRAKGIIAIC-WVLSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVP 173 T +AK II IC W+LS ++G++ + LG G + + + F D Sbjct: 230 RTPLKAK-IINICIWLLSSSVGISAIVLG---------GTKVREDVDVIECSLQFPDDDY 279 Query: 174 MNYMVYFN---FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVH 230 + ++ F ++P+L+++ Y + L +LK + + L G R + + + Sbjct: 280 SWWDLFMKICVFIFAFVIPVLIIIVCYTLMIL----RLKSV--RLLSGSREKDRNLRRI- 332 Query: 231 AAKSLAIIVGLFALCWLPLHI-INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYA 289 + + ++V +F +CW P+HI I S A L Y I L +TNS +NP +YA Sbjct: 333 -TRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYA 391 Query: 290 YRIREFRQTFR 300 + F++ FR Sbjct: 392 FLDENFKRCFR 402 >6DRY-A nrPDB Length = 411 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 105/228 (46%), Gaps = 24/228 (10%) Query: 14 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAA 73 L + + I GN LV AV L LQ TNYF++SLA AD+ VG+ +P A+ ++ F A Sbjct: 27 LMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIAL-LTIMFEAM 85 Query: 74 -------CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 C LF+ ++ + +SI+ L AI++DRYIAI+ P++ N + A I Sbjct: 86 WPLPLVLCPAWLFLD---VLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKIT 142 Query: 127 ICWVLSFAIGL-TPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 + W++S I + P+ G + + C+ ++M+ F A Sbjct: 143 VVWLISIGIAIPVPIKGI-----------ETDVDNPNNITCVLTKERFGDFML-FGSLAA 190 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAK 233 PL +M+ Y A +++ +E ++K +AA+ Sbjct: 191 FFTPLAIMIVTYFLTIHALQKKAADLEDNWETLNDNLKVIEKADNAAQ 238 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 2/102 (1%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDC 262 AA QLK + + + T+ E A+K L I+ LF L W P I N C C Sbjct: 302 AAAEQLKTTRNAYIQKYLVQ-TISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSC 360 Query: 263 SHAPL-WLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 + L L+ + + + + +S VNP +Y + FR F + I Sbjct: 361 NQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYI 402 >5ZBQ-A nrPDB Length = 525 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 143/302 (47%), Gaps = 34/302 (11%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFC- 71 A+ +L + GN+ + + ++NVTN +V+L+ +D+ V ++ +PF T+ + Sbjct: 48 AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVF 107 Query: 72 --AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI-IAIC 128 A C F+ C + + SI+SL+ IA++R+ I P G R + IA+ Sbjct: 108 GEAMCKLNPFVQCVSITV---SIWSLVLIAVERHQLIINP---RGWRPNNRHAYVGIAVI 161 Query: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 WVL+ A L ++ +P +N + + + C F+ ++ + + VL Sbjct: 162 WVLAVASSLPFLIYQVMTDEP--FQNVTLDAYKDKYVC-FDQFPSDSHRLSYTTLLLVLQ 218 Query: 189 ---PLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 245 PL + Y +I++ +R+ M+ + + RS+ K ++ L IV FA+C Sbjct: 219 YFGPLCFIFICYFKIYIRLKRRNNMMD--KMRDNKYRSSETKRINIM--LLSIVVAFAVC 274 Query: 246 WLPLHIINCFTFF------CPDCSHAPLWLM-YLAIVLSHTNSVVNPFIYAYRIREFRQT 298 WLPL I N T F C+H L+L+ +L ++S + VNP Y + + F++ Sbjct: 275 WLPLTIFN--TVFDWNHQIIATCNHNLLFLLCHLTAMIS---TCVNPIFYGFLNKNFQRD 329 Query: 299 FR 300 + Sbjct: 330 LQ 331 >5DSG-A nrPDB Length = 422 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 63/231 (27%), Positives = 106/231 (45%), Gaps = 20/231 (8%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP-FAITISTG 69 TV +++++ ++GN+LV ++ +N LQ V NYF+ SLA AD+ +G ++ + + I G Sbjct: 18 TVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKG 77 Query: 70 FC-AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C V++ +S+ +LL I+ DRY + PL Y T A +IA Sbjct: 78 YWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAA 137 Query: 129 WVLSFAIGLTPMLGWNN-CGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL 187 WVLSF + +L W G+ N A F + Y+ Sbjct: 138 WVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYL---------- 187 Query: 188 VPLLLMLGVYLRIFLAARRQ------LKQMESQPLPGERARSTLQKEVHAA 232 P+++M +Y+ I LA+R + L+ E G+ A ++V AA Sbjct: 188 -PVVIMTVLYIHISLASRSRVNIFEMLRIDEGGGSGGDEAEKLFNQDVDAA 237 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%) Query: 227 KEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPF 286 +E +++ I+ F L W P +++ FC C +W + L + NS +NP Sbjct: 329 RERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVW--SIGYWLCYVNSTINPA 386 Query: 287 IYAYRIREFRQTFRKII 303 YA F++TFR ++ Sbjct: 387 CYALCNATFKKTFRHLL 403 >4RWA-A nrPDB Length = 411 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 81/306 (26%), Positives = 141/306 (46%), Gaps = 43/306 (14%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAA- 73 A+ + +LGNVLV + + + ++ TN ++ +LA AD A+ +PF S + Sbjct: 131 AVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQ---SAKYLMET 186 Query: 74 -------CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 C L I + + +SIF+L +++DRYIA+ P++ T +AK +I Sbjct: 187 WPFGELLCKAVLSIDYYNMF---TSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAK-LIN 242 Query: 127 IC-WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN---- 181 IC WVL+ +G+ M+ +P+ +G V C+ + P Y Sbjct: 243 ICIWVLASGVGVPIMVM--AVTRPR----------DGAVVCMLQFPSPSWYWDTVTKICV 290 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGL 241 F +VP+L++ Y + L R S+ E+ RS + + + ++VG Sbjct: 291 FLFAFVVPILIITVCYGLMLLRLRSVRLLSGSK----EKDRSLRR----ITRMVLVVVGA 342 Query: 242 FALCWLPLHIINCFTFFCPDCSHAPLWL--MYLAIVLSHTNSVVNPFIYAYRIREFRQTF 299 F +CW P+HI PL + ++L I L + NS +NP +YA+ F++ F Sbjct: 343 FVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 402 Query: 300 RKIIRS 305 R++ R Sbjct: 403 RQLCRK 408 >5CXV-A nrPDB Length = 515 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 43/135 (31%), Positives = 75/135 (55%), Gaps = 10/135 (7%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACH 75 +++ + GN+LV + +N+ L+ V NYF++SLA AD+ +G F++ + T + H Sbjct: 60 LSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGT----FSMNLYTTYLLMGH 115 Query: 76 GCL-FIACFV-----LVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129 L +AC + V +Q+S+ +LL I+ DRY ++ PL Y T RA +I + W Sbjct: 116 WALGTLACDLWLALDYVASQASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAW 175 Query: 130 VLSFAIGLTPMLGWN 144 ++SF + +L W Sbjct: 176 LVSFVLWAPAILFWQ 190 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 31/80 (38%), Positives = 44/80 (55%), Gaps = 2/80 (2%) Query: 224 TLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVV 283 +L KE AA++L+ I+ F L W P +I+ + FC DC LW L L + NS + Sbjct: 405 SLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLW--ELGYWLCYVNSTI 462 Query: 284 NPFIYAYRIREFRQTFRKII 303 NP YA + FR TFR ++ Sbjct: 463 NPMCYALCNKAFRDTFRLLL 482 >5ZKB-A nrPDB Length = 421 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 104/228 (45%), Gaps = 26/228 (11%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAAC 74 +++++ I+GN+LV ++ +N +LQ V NYF+ SLA AD+ +GV F++ + T + Sbjct: 34 SLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGV----FSMNLYTLYTVIG 89 Query: 75 HG------CLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C V++ + + +LL I+ DRY + PL Y T A +IA Sbjct: 90 YWPLGPVVCDLWLALDYVVSNARVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAA 149 Query: 129 WVLSFAIGLTPMLGWN---NCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 WVLSF + +L W ++G+ + Q V + A Sbjct: 150 WVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVT-------------FGTAIAA 196 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAK 233 +P+++M +Y I A++ ++ +E ++K +AA+ Sbjct: 197 FYLPVIIMTVLYWHISRASKSRIADLEDNWETLNDNLKVIEKADNAAQ 244 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/104 (25%), Positives = 48/104 (46%), Gaps = 4/104 (3%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDC 262 AA QLK + + + +K+V +++ I+ F + W P +++ FC C Sbjct: 308 AAAEQLKTTRNAYIQKYLPPPSREKKV--TRTILAILLAFIITWAPYNVMVLINTFCAPC 365 Query: 263 SHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH 306 +W + L + NS +NP YA F++TF+ ++ H Sbjct: 366 IPNTVWT--IGYWLCYINSTINPACYALCNATFKKTFKHLLMCH 407 >3UON-A nrPDB Length = 467 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 107/232 (46%), Gaps = 27/232 (11%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAAC 74 +++++ I+GN+LV ++ +N +LQ V NYF+ SLA AD+ +GV F++ + T + Sbjct: 32 SLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGV----FSMNLYTLYTVIG 87 Query: 75 HG------CLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C V++ +S+ +LL I+ DRY + PL Y T A +IA Sbjct: 88 YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAA 147 Query: 129 WVLSFAIGLTPMLGWN---NCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 WVLSF + +L W ++G+ + Q V F + Y+ Sbjct: 148 WVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVT--FGTAIAAFYL-------- 197 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 P+++M +Y I A++ ++ E + E R + K+ ++ I Sbjct: 198 ---PVIIMTVLYWHISRASKSRINIFEMLRI-DEGLRLKIYKDTEGYYTIGI 245 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 2/81 (2%) Query: 226 QKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNP 285 +E +++ I+ F + W P +++ FC C +W + L + NS +NP Sbjct: 381 SREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWT--IGYWLCYINSTINP 438 Query: 286 FIYAYRIREFRQTFRKIIRSH 306 YA F++TF+ ++ H Sbjct: 439 ACYALCNATFKKTFKHLLMCH 459 >5DYS-A nrPDB Length = 349 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 63/289 (21%), Positives = 120/289 (41%), Gaps = 43/289 (14%) Query: 24 NVLVCWAVWLNSNLQNVTNYFVVSLAAADI--AVGVLAIPFAITISTGFCAACHGCLFIA 81 N L + + L+ NY +++LA AD+ G ++ F GC Sbjct: 56 NFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTILYTSLHGYFVFGPTGCNLEG 115 Query: 82 CFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPML 141 F + + +++SL+ +AI+RY+ + P+ N A +A WV++ A P++ Sbjct: 116 FFATLGGEIALWSLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAFTWVMALACAAPPLV 174 Query: 142 GWN---------NCG----QPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 GW+ +CG P E N+ E V ++V+F ++ Sbjct: 175 GWSRYIPEGMQCSCGIDYYTPHEETNN-------------ESFVIYMFVVHF------II 215 Query: 189 PLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLP 248 PL+++ Y ++ + Q + + +T + E + + I+V F +CWLP Sbjct: 216 PLIVIFFCYGQLVFTVKEAAAQQ-------QESATTQKAEKEVTRMVIIMVIAFLICWLP 268 Query: 249 LHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 297 + + F P++ M + + T++V NP IY ++FR Sbjct: 269 YAGVAFYIFTHQGSCFGPIF-MTIPAFFAKTSAVYNPVIYIMMNKQFRN 316 >6DDF-R nrPDB Length = 356 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 73/295 (24%), Positives = 132/295 (44%), Gaps = 32/295 (10%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACH 75 + V+ + GN LV + + + ++ TN ++ +LA AD A+ +PF S + Sbjct: 76 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQ---SVNYLMGTW 131 Query: 76 GCLFIACFVLVLTQ-----SSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC-W 129 I C +++ +SIF+L +++DRYIA+ P++ T AK I+ +C W Sbjct: 132 PFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAK-IVNVCNW 190 Query: 130 VLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189 +LS AIGL M + QG + + N + F ++P Sbjct: 191 ILSSAIGLPVMF--------MATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMP 242 Query: 190 LLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPL 249 +L++ Y + L +LK + L G + + + + + + ++V +F +CW P+ Sbjct: 243 VLIITVCYGLMIL----RLKSVRM--LSGSKEKDRNLRRI--TRMVLVVVAVFIVCWTPI 294 Query: 250 H---IINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRK 301 H II W + I L +TNS +NP +YA+ F++ FR+ Sbjct: 295 HIYVIIKALITIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCFRE 347 >3V2Y-A nrPDB Length = 520 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 93/211 (44%), Gaps = 36/211 (17%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVL---------AIPF 62 V + I IL N+ V +W YF+ +LA +D+ GV A + Sbjct: 69 VFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTY 128 Query: 63 AITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 122 +T + F G +F+A +S+FSLLAIAI+RYI + +NG R Sbjct: 129 KLTPAQWFLR--EGSMFVAL------SASVFSLLAIAIERYITMLKMKLHNG-SNNFRLF 179 Query: 123 GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182 +I+ CWV+S +G P++GWN C +C V+P+ + Y F Sbjct: 180 LLISACWVISLILGGLPIMGWN--------------CISALSSC--STVLPLYHKHYILF 223 Query: 183 FACVLVPLLLMLGV-YLRIFLAAR-RQLKQM 211 V LLL + + Y RI+ R R + +M Sbjct: 224 CTTVFTLLLLSIVILYCRIYSLVRTRNIFEM 254 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 2/100 (2%) Query: 204 ARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCS 263 A+R + + +RS+ + V K++ I++ +F CW PL I+ C + Sbjct: 394 AKRVITTFRTGTWDAYASRSS--ENVALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKT 451 Query: 264 HAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 L+ +VL+ NS NP IY +E R+ F +I+ Sbjct: 452 CDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIM 491 >5WIV-A nrPDB Length = 422 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 37/103 (35%), Positives = 52/103 (50%), Gaps = 2/103 (1%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDC 262 AA QLK + + A+ T +E A + L ++VG F LCW P +++ CP C Sbjct: 320 AAAEQLKTTRNAYIQKYLAKIT-GRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPAC 378 Query: 263 SHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 S P L+ L + NS +NP IY EFR FRK +R+ Sbjct: 379 SVPPR-LVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRA 420 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 63/193 (32%), Positives = 95/193 (49%), Gaps = 21/193 (10%) Query: 17 AVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP---FAITISTGFCAA 73 AVLA GN LVC +V LQ TN F+VSLAAAD+ + +L +P ++ + + Sbjct: 51 AVLA--GNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLS 108 Query: 74 CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSF 133 C + ++L +SIF+L AI++DR++A+ +PLRYN R +I W+LS Sbjct: 109 PRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA 168 Query: 134 AIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLM 193 A+ + G N+ G C ED +Y+VY + + L P LM Sbjct: 169 AVAAPVLCGLNDVR------------GRDPAVCRLED---RDYVVYSSVCSFFL-PCPLM 212 Query: 194 LGVYLRIFLAARR 206 L +Y F +R Sbjct: 213 LLLYWATFRGLQR 225 >5ZTY-A nrPDB Length = 500 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 47/137 (34%), Positives = 71/137 (51%), Gaps = 4/137 (2%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNY-FVVSLAAAD-IAVGVLAIPFA-ITISTGFCA 72 + +L+ L NV V + + + L+ +Y F+ SLA AD +A V A F + G + Sbjct: 42 LGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLALADFLASVVFACSFVNFHVFHGVDS 101 Query: 73 ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132 L I + T +S+ SLL AIDRY+ +R P Y L+T RA ++ I WVLS Sbjct: 102 KAVFLLKIGSVTMTFT-ASVGSLLLAAIDRYLCLRYPPSYKALLTRGRALVLLGIMWVLS 160 Query: 133 FAIGLTPMLGWNNCGQP 149 + P++GW C +P Sbjct: 161 ALVSYLPLMGWTCCPRP 177 Score = 36.2 bits (82), Expect = 0.028, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%) Query: 221 ARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTN 280 A + ++ +V AK+L +++ + +CW P+ + + + ++ L N Sbjct: 380 AYARMRLDVELAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSM-LCLIN 438 Query: 281 SVVNPFIYAYRIREFRQT 298 S+VNP IYA R E R + Sbjct: 439 SMVNPVIYALRSEEIRSS 456 >5U09-A nrPDB Length = 508 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 70/230 (30%), Positives = 100/230 (43%), Gaps = 33/230 (14%) Query: 13 ELAIAVLA-------ILGNVLVCWAVWLNSNLQNVTNY-FVVSLAAADIAVGVLAIPFAI 64 +LAIAVL+ +L N+LV + + +L+ +Y F+ SLA AD+ V+ + I Sbjct: 28 QLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFI 87 Query: 65 TISTGFCAACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 LF V +S+ SL AIDRYI+I PL Y +VT R K Sbjct: 88 DFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLAAIDRYISIHRPLAYKRIVT--RPKA 145 Query: 124 IIAIC--WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 ++A C W ++ I + P+LGWN C + Q C D+ P Y Sbjct: 146 VVAFCLMWTIAIVIAVLPLLGWN--------------CEKLQSVC--SDIFPHIDETYLM 189 Query: 182 FFACVL-VPLLLMLGVYLRIFLAARRQLKQMESQPLPG---ERARSTLQK 227 F+ V V LL ++ Y+ I A L G ER +S L K Sbjct: 190 FWIGVTSVLLLFIVYAYMYILWKAGIDCSFWNESYLTGSRDERKKSLLSK 239 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Query: 226 QKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNP 285 + ++ AK+L +I+ + +CW PL I + F + ++ L NS VNP Sbjct: 413 RMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSM-LCLLNSTVNP 471 Query: 286 FIYAYRIREFRQTFRKIIRS 305 IYA R ++ R FR + S Sbjct: 472 IIYALRSKDLRHAFRSMFPS 491 >5C1M-A nrPDB Length = 296 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 131/293 (44%), Gaps = 32/293 (10%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACH 75 + V+ + GN LV + + + ++ TN ++ +LA AD A+ +PF S + Sbjct: 27 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQ---SVNYLMGTW 82 Query: 76 GCLFIACFVLVLTQ-----SSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC-W 129 I C +++ +SIF+L +++DRYIA+ P++ T AK I+ +C W Sbjct: 83 PFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAK-IVNVCNW 141 Query: 130 VLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189 +LS AIGL M + QG + + N + F ++P Sbjct: 142 ILSSAIGLPVMF--------MATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMP 193 Query: 190 LLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPL 249 +L++ Y + L +LK + + L G + + + + + + ++V +F +CW P+ Sbjct: 194 VLIITVCYGLMIL----RLKSV--RMLSGSKEKDRNLRRI--TRMVLVVVAVFIVCWTPI 245 Query: 250 H---IINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 299 H II W + I L +TNS +NP +YA+ F++ F Sbjct: 246 HIYVIIKALITIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCF 296 >5XRA-A nrPDB Length = 438 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 62/201 (30%), Positives = 93/201 (46%), Gaps = 30/201 (14%) Query: 13 ELAIAVLA-------ILGNVLVCWAVWLNSNLQNVTNY-FVVSLAAADIAVGVLAIPFAI 64 +LAIAVL+ +L N+LV + + +L+ +Y F+ SLA AD+ V+ + I Sbjct: 18 QLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFI 77 Query: 65 TISTGFCAACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 LF V +S+ SL AIDRYI+I PL Y +VT R K Sbjct: 78 DFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLAAIDRYISIHRPLAYKRIVT--RPKA 135 Query: 124 IIAIC--WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 ++A C W ++ I + P+LGWN C + Q C D+ P Y Sbjct: 136 VVAFCLMWTIAIVIAVLPLLGWN--------------CEKLQSVC--SDIFPHIDKTYLM 179 Query: 182 FFACVLVPLLLMLGVYLRIFL 202 F+ V V +LL+ VY +++ Sbjct: 180 FWIGV-VSVLLLFIVYAYMYI 199 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Query: 226 QKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNP 285 + ++ AK+L +I+ + +CW PL I + F + ++ L NS VNP Sbjct: 360 RMDIELAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSM-LCLLNSTVNP 418 Query: 286 FIYAYRIREFRQTFRKIIRS 305 IYA R ++ R FR + S Sbjct: 419 IIYALRSKDLRHAFRSMFPS 438 >3AYN-A nrPDB Length = 448 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 64/290 (22%), Positives = 112/290 (38%), Gaps = 53/290 (18%) Query: 34 NSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCL-------FIACFVL- 85 +LQ N F+++LA +D F ++ GF C F AC V Sbjct: 62 TKSLQTPANMFIINLAFSD---------FTFSLVNGFPLMTISCFLKKWIFGFAACKVYG 112 Query: 86 ----VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPML 141 + SI ++ I+IDRY I P+ + ++ RA +I W+ S + P+ Sbjct: 113 FIGGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIF 172 Query: 142 GWN---------NCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLL 192 GW NC ++ + + C+F FF P+L+ Sbjct: 173 GWGAYTLEGVLCNCSFDYISRDSTT---RSNILCMF----------ILGFFG----PILI 215 Query: 193 MLGVYLRIFLAARRQLKQMES-----QPLPGERARSTLQKEVHAAKSLAIIVGLFALCWL 247 + Y I ++ K+M + +A++ E+ AK +IV F L W Sbjct: 216 IFFCYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWS 275 Query: 248 PLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 297 P ++ F P P + L ++ + +++ NP IY+ +FR+ Sbjct: 276 PYAVVALLAQFGPLEWVTP-YAAQLPVMFAKASAIHNPMIYSVSHPKFRE 324 >4WW3-A nrPDB Length = 350 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/290 (22%), Positives = 112/290 (38%), Gaps = 53/290 (18%) Query: 34 NSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCL-------FIACFVL- 85 +LQ N F+++LA +D F ++ GF C F AC V Sbjct: 54 TKSLQTPANMFIINLAFSD---------FTFSLVNGFPLMTISCFLKKWIFGFAACKVYG 104 Query: 86 ----VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPML 141 + SI ++ I+IDRY I P+ + ++ RA +I W+ S + P+ Sbjct: 105 FIGGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIF 164 Query: 142 GWN---------NCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLL 192 GW NC ++ + + C+F FF P+L+ Sbjct: 165 GWGAYTLEGVLCNCSFDYISRDSTT---RSNILCMF----------ILGFFG----PILI 207 Query: 193 MLGVYLRIFLAARRQLKQMES-----QPLPGERARSTLQKEVHAAKSLAIIVGLFALCWL 247 + Y I ++ K+M + +A++ E+ AK +IV F L W Sbjct: 208 IFFCYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWS 267 Query: 248 PLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 297 P ++ F P P + L ++ + +++ NP IY+ +FR+ Sbjct: 268 PYAVVALLAQFGPLEWVTP-YAAQLPVMFAKASAIHNPMIYSVSHPKFRE 316 >5W0P-A nrPDB Length = 906 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 61/285 (21%), Positives = 121/285 (42%), Gaps = 20/285 (7%) Query: 18 VLAILG---NVLVCWAVWLNSNLQNVTNYFVVSLAAADI--AVGVLAIPFAITISTGFCA 72 +L +LG N L + + L+ NY +++LA AD+ +G ++ F Sbjct: 206 LLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVF 265 Query: 73 ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132 GC F + + +++SL+ +AI+RY+ + P+ N A +A WV++ Sbjct: 266 GPTGCNLQGFFATLGGEIALWSLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAFTWVMA 324 Query: 133 FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLL 192 A P+ GW+ EG S G L +V ++++Y F +P+++ Sbjct: 325 LACAAPPLAGWSRY--IPEGLQCSCGI---DYYTLKPEVNNESFVIYM-FVVHFTIPMII 378 Query: 193 MLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHII 252 + Y ++ + Q + + +T + E + + I V F +CW+P + Sbjct: 379 IFFCYGQLVFTVKEAAAQQ-------QESATTQKAEKEVTRMVIIYVIAFLICWVPYASV 431 Query: 253 NCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 297 + F P++ M + + + ++ NP IY ++FR Sbjct: 432 AFYIFTHQGSCFGPIF-MTIPAFFAKSAAIYNPVIYIMMNKQFRN 475 >6CMO-R nrPDB Length = 463 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 61/285 (21%), Positives = 121/285 (42%), Gaps = 20/285 (7%) Query: 18 VLAILG---NVLVCWAVWLNSNLQNVTNYFVVSLAAADI--AVGVLAIPFAITISTGFCA 72 +L +LG N L + + L+ NY +++LA AD+ +G ++ F Sbjct: 186 LLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVF 245 Query: 73 ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132 GC F + + +++SL+ +AI+RY+ + P+ N A +A WV++ Sbjct: 246 GPTGCNLQGFFATLGGEIALWSLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAFTWVMA 304 Query: 133 FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLL 192 A P+ GW+ EG S G L +V ++++Y F +P+++ Sbjct: 305 LACAAPPLAGWSR--YIPEGLQCSCGI---DYYTLKPEVNNESFVIYM-FVVHFTIPMII 358 Query: 193 MLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHII 252 + Y ++ + Q + + +T + E + + I V F +CW+P + Sbjct: 359 IFFCYGQLVFTVKEAAAQQ-------QESATTQKAEKEVTRMVIIYVIAFLICWVPYASV 411 Query: 253 NCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 297 + F P++ M + + + ++ NP IY ++FR Sbjct: 412 AFYIFTHQGSCFGPIF-MTIPAFFAKSAAIYNPVIYIMMNKQFRN 455 >4EJ4-A nrPDB Length = 461 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/147 (30%), Positives = 76/147 (51%), Gaps = 19/147 (12%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAA- 73 A+ + +LGNVLV + + + L+ TN ++ +LA AD A+ +PF S + Sbjct: 23 AVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALAD-ALATSTLPFQ---SAKYLMET 78 Query: 74 -------CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 C L I + + +SIF+L +++DRYIA+ P++ T +AK +I Sbjct: 79 WPFGELLCKAVLSIDYYNMF---TSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAK-LIN 134 Query: 127 IC-WVLSFAIGLTPMLGWNNCGQPKEG 152 IC WVL+ +G+ M+ QP++G Sbjct: 135 ICIWVLASGVGVPIMVM--AVTQPRDG 159 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 22/69 (31%), Positives = 36/69 (52%), Gaps = 2/69 (2%) Query: 245 CWLPLHIINCFTFFCPDCSHAPLWL--MYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKI 302 CW P+HI PL + ++L I L + NS +NP +YA+ F++ FR++ Sbjct: 392 CWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQL 451 Query: 303 IRSHVLRQQ 311 R+ RQ+ Sbjct: 452 CRTPCGRQE 460 >4ZUD-A nrPDB Length = 410 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 72/307 (23%), Positives = 130/307 (42%), Gaps = 54/307 (17%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP-FAITISTGFC--A 72 I V+ I GN LV ++ L+ V + F+++LA AD+ +L +P +A+ + + Sbjct: 133 IFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCF-LLTLPLWAVYTAMEYRWPF 191 Query: 73 ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132 + C + V +S+F L ++IDRY+AI P++ T AK I W+L+ Sbjct: 192 GNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLA 251 Query: 133 FAIGLTPMLGWN----------NCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182 L ++ N C E +N + G G L ++++ Sbjct: 252 GLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLG----LTKNILGF-------- 299 Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLF 242 L P L++L Y I+ A ++ + +++P + K + IV F Sbjct: 300 ----LFPFLIILTSYTLIWKALKKAYEIQKNKP-----------RNDDIFKIIMAIVLFF 344 Query: 243 ALCWLPLHIINCFTFF--------CPDCSHAPL--WLMYLAIVLSHTNSVVNPFIYAYRI 292 W+P I FTF DC A + M + I +++ N+ +NP Y + Sbjct: 345 FFSWIPHQI---FTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLG 401 Query: 293 REFRQTF 299 ++F++ F Sbjct: 402 KKFKRYF 408 >6ME9-A nrPDB Length = 460 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 77/342 (22%), Positives = 133/342 (38%), Gaps = 70/342 (20%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTG 69 V + + ++GN+LV +V N L+N N F+VSLA A++ V P + G Sbjct: 122 VLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALANLVVAFYPYPLILVAIFYDG 181 Query: 70 FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129 + C A + + S++++ AIAIDRY+ I + Y+ + I + W Sbjct: 182 WAFGEEHCKASAFVMGLSVIGSVWNITAIAIDRYLYICHSMAYHRIYRRWHTPLHICLIW 241 Query: 130 VLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQ---VACLFEDVVPMNYMVYFNFFACV 186 +L+ + L P N G E +C F Y A V Sbjct: 242 LLT-VVALLP--------------NFFVGSLEYDPRIYSCTFIQTASTQYTA-----AVV 281 Query: 187 LVPLLLMLGV----YLRIF---LAARRQ---------------------------LKQME 212 ++ LL + V YLRI+ L AR + K + Sbjct: 282 VIHFLLPIAVVSFCYLRIWVLVLQARMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIP 341 Query: 213 SQ---PLPG------ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD-- 261 PL G E ++ + ++ ++ +FA+C+ PL+ I P Sbjct: 342 DDWVCPLCGVGKDQFEEVECLKPSDLRSFLTMFVVFVIFAICFAPLNCIGLAVAINPQEM 401 Query: 262 CSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 P L + +L++ NS +NP +Y + FR+ +++I+ Sbjct: 402 APQIPEGLFVTSYLLAYFNSCLNPIVYGLLDQNFRREYKRIL 443 >6J20-A nrPDB Length = 441 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 4/111 (3%) Query: 29 WAVWLNSNLQNVTNYFVVSLAAADIAVGVL--AIPFAITISTGFCAACHGCLFIACFVLV 86 W + + ++ VTNYF+V+LA A+ ++ + F + + C F F + Sbjct: 54 WIILAHKRMRTVTNYFLVNLAFANASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIA 113 Query: 87 LTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGL 137 +SI+S+ A+A DRY+AI PL+ ++ T K +I + WVL+ + Sbjct: 114 AVFASIWSMTAVAFDRYMAIIHPLQ--PRLSATATKVVICVIWVLALLLAF 162 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 23/65 (35%), Positives = 34/65 (52%), Gaps = 2/65 (3%) Query: 242 FALCWLPLHIINCFTFFCPDCSHAP-LWLMYLAIV-LSHTNSVVNPFIYAYRIREFRQTF 299 FA+CWLP HI + PD + +YLAI+ L+ ++++ NP IY FR F Sbjct: 363 FAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGF 422 Query: 300 RKIIR 304 + R Sbjct: 423 KHAFR 427 >4DKL-A nrPDB Length = 464 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 44/147 (29%), Positives = 75/147 (51%), Gaps = 12/147 (8%) Query: 2 PIMGSSVYITVELAIA-VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 P M +++ I +I V+ + GN LV + + + ++ TN ++ +LA AD A+ + Sbjct: 12 PSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTL 70 Query: 61 PFAITISTGFCAACHGCLFIACFVLVLTQ-----SSIFSLLAIAIDRYIAIRIPLRYNGL 115 PF S + I C +++ +SIF+L +++DRYIA+ P++ Sbjct: 71 PFQ---SVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF 127 Query: 116 VTGTRAKGIIAIC-WVLSFAIGLTPML 141 T AK I+ +C W+LS AIGL M Sbjct: 128 RTPRNAK-IVNVCNWILSSAIGLPVMF 153 Score = 34.7 bits (78), Expect = 0.075, Method: Compositional matrix adjust. Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 5/60 (8%) Query: 245 CWLPLHI---INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRK 301 CW P+HI I W + I L +TNS +NP +YA+ F++ FR+ Sbjct: 395 CWTPIHIYVIIKALITIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCFRE 452 >4DJH-A nrPDB Length = 480 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 45/147 (30%), Positives = 82/147 (55%), Gaps = 15/147 (10%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 +P++ ++VY V V+ ++GN LV + + + ++ TN ++ +LA AD A+ + Sbjct: 21 IPVIITAVYSVV----FVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD-ALVTTTM 75 Query: 61 PFAITI----STGFCAA-CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGL 115 PF T+ S F C L I + + +SIF+L +++DRYIA+ P++ Sbjct: 76 PFQSTVYLMNSWPFGDVLCKIVLSIDYYNMF---TSIFTLTMMSVDRYIAVCHPVKALDF 132 Query: 116 VTGTRAKGIIAIC-WVLSFAIGLTPML 141 T +AK II IC W+LS ++G++ ++ Sbjct: 133 RTPLKAK-IINICIWLLSSSVGISAIV 158 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 245 CWLPLHI-INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRK 301 CW P+HI I S A L Y I L +TNS +NP +YA+ F++ FR Sbjct: 408 CWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRD 465 >4XEE-A nrPDB Length = 541 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 63/261 (24%), Positives = 103/261 (39%), Gaps = 53/261 (20%) Query: 72 AACHGCLFI--ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129 A C G F+ AC T ++ ++ +++++RY+AI P + L++ +R K I+ W Sbjct: 108 AGCRGYYFLRDAC-----TYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIW 162 Query: 130 VLS--FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACL-FEDVVPMNYMVYFNFFACV 186 + S AI + +G N + G G + C D + ++ N F Sbjct: 163 LASALLAIPMLFTMGLQN--------RSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSF 214 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERA----------RSTLQKEV------- 229 L P+L++ L +A +L M Q R ST + Sbjct: 215 LFPMLVI--SILNTVIA--NKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRVQA 270 Query: 230 --HAAKSLAIIVGLFALCWLPLHI---INCF------TFFCPDCSHAPLWLMYLAIVLSH 278 H L +V F +CWLP H+ + C+ T F D H + L L + Sbjct: 271 LRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYH---YFYMLTNALFY 327 Query: 279 TNSVVNPFIYAYRIREFRQTF 299 +S +NP +Y FRQ F Sbjct: 328 ASSAINPILYNLVSANFRQVF 348 >4BWB-A nrPDB Length = 338 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/244 (25%), Positives = 102/244 (41%), Gaps = 35/244 (14%) Query: 72 AACHGCLFI--ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129 A C G F+ AC T ++ ++++++++ Y+AI P + L++ +R K I+ W Sbjct: 95 AGCKGYYFLREAC-----TYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIW 149 Query: 130 VLS--FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACL-FEDVVPMNYMVYFNFFACV 186 + S AI + +G N G G + C D + ++ N F Sbjct: 150 LASALLAIPMLFTMGLQNLS--------GDGTHPGGLVCTPIVDTATLRVVIQLNTFMSF 201 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERAR-STLQKEVHAAKS----LAIIVGL 241 L P+L V + A R+L M Q E+ R T V A + L +V Sbjct: 202 LFPML----VASILNTVAARRLTVMVHQ--AAEQGRVCTEPGRVQALRRGVLVLRAVVIA 255 Query: 242 FALCWLPLHIINC-FTFFCPDCSHAPLWLMY-----LAIVLSHTNSVVNPFIYAYRIREF 295 F +CWLP H+ F + + L+ Y L+ L + ++ +NP +Y F Sbjct: 256 FVVCWLPYHVRRLMFVYISDEQWTTALFDFYHYFYMLSNALVYVSAAINPILYNLVSANF 315 Query: 296 RQTF 299 RQ F Sbjct: 316 RQVF 319 >4Z36-A nrPDB Length = 459 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 6/102 (5%) Query: 203 AARRQLKQMESQPLPGE-RARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD 261 AA QLK + + R R T+ + K++ I++G F +CW P ++ CP Sbjct: 334 AAAEQLKTTRNAYIQKYLRNRDTMMSLL---KTVVIVLGAFIICWTPGLVLLLLDCCCPQ 390 Query: 262 CSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 C +L +L+ NS +NP IY+YR +E TFR+I+ Sbjct: 391 CDVLAYEKFFL--LLAEFNSAMNPIIYSYRDKEMSATFRQIL 430 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 69/142 (48%), Gaps = 6/142 (4%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT 65 S + + + + + + +L N+LV A+++N Y + +LAAAD G+ F + Sbjct: 67 SKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY--FYLM 124 Query: 66 ISTGFCA---ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 122 +TG L + +S+ +LLAIAI+R+I + ++ + ++ R Sbjct: 125 FNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVV 183 Query: 123 GIIAICWVLSFAIGLTPMLGWN 144 +I + W ++ +G P +GWN Sbjct: 184 VVIVVIWTMAIVMGAIPSVGWN 205 >5VBL-B nrPDB Length = 407 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 76/337 (22%), Positives = 133/337 (39%), Gaps = 62/337 (18%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVT-NYFVVSLAAADIAVGVLAIPFAITIS--- 67 + + + +L GN LV W V+ +S + + + F+ SLA AD+ V+ +P T + Sbjct: 52 IYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTF-VVTLPLWATYTYRD 110 Query: 68 ------TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 121 T FC +F+ + +S F L ++ DRY+AI P+ L Sbjct: 111 YDWPFGTFFCKLSSYLIFVNMY------ASAFCLTGLSFDRYLAIVRPVANARLRLRVSG 164 Query: 122 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 A+ WVL+ A+ P++ G + VA + + + + Sbjct: 165 AVATAVLWVLA-ALLAMPVMVLRTTGDLENTNKVQCYMDYSMVATVSSEWAWEVGLGVSS 223 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQ------------------------MESQPLP 217 +VP +ML Y F+A +K+ + + +P Sbjct: 224 TTVGFVVPFTIMLTCYF--FIAQTIAMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIP 281 Query: 218 GERA-------RSTLQKEVHAAKSLAIIVGL---FALCWLPLHIINCFTFFCPDCSHAP- 266 + + ++ + L+IIV L FALC +P H++ + H P Sbjct: 282 DDWVCPLCGVGKDQFEEVEERRRLLSIIVVLVVTFALCKMPYHLVKTL-YMLGSLLHWPC 340 Query: 267 ---LWLMYL---AIVLSHTNSVVNPFIYAYRIREFRQ 297 L+LM + +S+ NS +NPF+YA+ FRQ Sbjct: 341 DFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQ 377 >4BUO-A nrPDB Length = 335 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 57/244 (23%), Positives = 97/244 (39%), Gaps = 37/244 (15%) Query: 72 AACHGCLFI--ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129 A C G F+ AC T ++ ++++++++ Y+AI P + L++ +R K I+ W Sbjct: 94 AGCRGYYFLRDAC-----TYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIW 148 Query: 130 VLS--FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACL-FEDVVPMNYMVYFNFFACV 186 + S AI + +G N G G + C D + ++ N F Sbjct: 149 LASALLAIPMLFTMGLQNLS--------GDGTHPGGLVCTPIVDTATLKVVIQVNTFMSF 200 Query: 187 LVPLLL--MLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL 244 L P+L+ +L + L PG +Q L +V F + Sbjct: 201 LFPMLVASILNTVIANKLTVMVHQAAFNMTIEPGR-----VQALRRGVLVLRAVVIAFVV 255 Query: 245 CWLPLHI---INCF------TFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREF 295 CWLP H+ + C+ T F D H + L L + ++ +NP +Y F Sbjct: 256 CWLPYHVRRLMFCYISDEQWTTFLFDFYH---YFYMLTNALVYVSAAINPILYNLVSANF 312 Query: 296 RQTF 299 RQ F Sbjct: 313 RQVF 316 >5ZBH-A nrPDB Length = 527 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 95/202 (47%), Gaps = 18/202 (8%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFC- 71 A+ +L + GN+ + + ++NVTN +V+L+ +D+ V ++ +PF T+ + Sbjct: 58 AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVF 117 Query: 72 --AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI-IAIC 128 A C F+ C + + SI+SL+ IA++R+ I P G R + IA+ Sbjct: 118 GEAMCKLNPFVQCVSITV---SIWSLVLIAVERHQLIINP---RGWRPNNRHAYVGIAVI 171 Query: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 WVL+ A L ++ +P +N + + + C F+ ++ + + VL Sbjct: 172 WVLAVASSLPFLIYQVMTDEP--FQNVTLDAYKDKYVC-FDQFPSDSHRLSYTTLLLVLQ 228 Query: 189 ---PLLLMLGVYLRIFLAARRQ 207 PL + Y +I++ +R+ Sbjct: 229 YFGPLCFIFICYFKIYIRLKRR 250 Score = 34.3 bits (77), Expect = 0.093, Method: Compositional matrix adjust. Identities = 28/90 (31%), Positives = 45/90 (50%), Gaps = 14/90 (15%) Query: 218 GERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF------CPDCSHAPLWLM- 270 + RS+ K ++ L IV FA+CWLPL I N T F C+H L+L+ Sbjct: 411 DNKYRSSETKRINIM--LLSIVVAFAVCWLPLTIFN--TVFDWNHQIIATCNHNLLFLLC 466 Query: 271 YLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300 +L ++S + VNP Y + + F++ + Sbjct: 467 HLTAMIS---TCVNPIFYGFLNKNFQRDLQ 493 >6HLP-A nrPDB Length = 520 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 57/113 (50%), Gaps = 4/113 (3%) Query: 27 VCWAVWLNSNLQNVTNYFVVSLAAADIAVGVL--AIPFAITISTGFCAACHGCLFIACFV 84 V W + + ++ VTNYF+V+ A A+ ++ + F + + C F F Sbjct: 53 VMWIILAHKRMRTVTNYFLVNAAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFP 112 Query: 85 LVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGL 137 + +SI+S+ A+A DRY+AI PL+ +T T+ +I + WVL+ + Sbjct: 113 IAAIFASIYSMTAVAFDRYMAIIHPLQPRLSLTATKV--VICVIWVLALLLAF 163 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 23/65 (35%), Positives = 34/65 (52%), Gaps = 2/65 (3%) Query: 242 FALCWLPLHIINCFTFFCPDCSHAP-LWLMYLAIV-LSHTNSVVNPFIYAYRIREFRQTF 299 FA+CWLP HI + PD + +YLAI+ L+ ++++ NP IY FR F Sbjct: 442 FAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGF 501 Query: 300 RKIIR 304 + R Sbjct: 502 KHAFR 506 >5XJM-A nrPDB Length = 422 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/113 (30%), Positives = 50/113 (44%), Gaps = 17/113 (15%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF---- 258 AA QLK + + + +V K A +V F +CWLP H++ TF Sbjct: 298 AAAEQLKTTRNAYIQKYLKNRITRDQV--LKMAAAVVLAFIICWLPFHVL---TFLDALA 352 Query: 259 -------CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 C + L L + AI+L TNS VNPF+Y + F+Q R + R Sbjct: 353 WMGVINSCEVIAVIDLALPF-AILLGFTNSCVNPFLYCFVGNRFQQKLRSVFR 404 >5GLH-A nrPDB Length = 498 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 2/131 (1%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAA 73 + VL I+GN + + ++ N ++N N + SLA D+ V+AIP + ++ + Sbjct: 49 VFVLGIIGNSTLLYIIYKNKCMRNGPNILIASLALGDLLHIVIAIPINVYKLLAEDWPFG 108 Query: 74 CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSF 133 C + ++ SL A++IDRY A+ R G+ I + WV+S Sbjct: 109 AEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSV 168 Query: 134 AIGLTPMLGWN 144 + + +G++ Sbjct: 169 VLAVPEAIGFD 179 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 25/84 (29%), Positives = 40/84 (47%), Gaps = 8/84 (9%) Query: 225 LQKEVHAAKSLAIIVGLFALCWLPLH---IINCFTFFCPDCSHAPLW-----LMYLAIVL 276 L++ AK++ +V +FALCWLPLH I+ + D + L L Y+ I + Sbjct: 406 LKQRREVAKTVFCLVLVFALCWLPLHLARILKLTLYNQNDPNRCELLSFLLVLDYIGINM 465 Query: 277 SHTNSVVNPFIYAYRIREFRQTFR 300 + NS NP + F+ F+ Sbjct: 466 ASLNSCANPIALYLVSKRFKNAFK 489 >5UNF-A nrPDB Length = 411 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 26/129 (20%) Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCW 246 ++PL+ + Y I R+ L + S ++ + ++ K A +V F +CW Sbjct: 297 IIPLIFIATCYFGI----RKHLLKTNSY------GKNRITRD-QVLKMAAAVVLAFIICW 345 Query: 247 LPLHIINCFTFF-----------CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREF 295 LP H++ TF C + L L + AI+L TNS VNPF+Y + F Sbjct: 346 LPFHVL---TFLDALAWMGVINSCEVIAVIDLALPF-AILLGFTNSCVNPFLYCFVGNRF 401 Query: 296 RQTFRKIIR 304 +Q R + R Sbjct: 402 QQKLRSVFR 410 >5GLI-A nrPDB Length = 464 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 33/135 (24%), Positives = 62/135 (45%), Gaps = 2/135 (1%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTG 69 V + VL I+GN + + ++ N ++N N + SLA D+ V+AIP + ++ Sbjct: 45 VSCLVFVLGIIGNSTLLYIIYKNKCMRNGPNILIASLALGDLLHIVIAIPINVYKLLAED 104 Query: 70 FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129 + C + ++ SL A++IDRY A+ R G+ I + W Sbjct: 105 WPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIW 164 Query: 130 VLSFAIGLTPMLGWN 144 V+S + + +G++ Sbjct: 165 VVSVVLAVPEAIGFD 179 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 25/84 (29%), Positives = 40/84 (47%), Gaps = 8/84 (9%) Query: 225 LQKEVHAAKSLAIIVGLFALCWLPLH---IINCFTFFCPDCSHAPLW-----LMYLAIVL 276 L++ AK++ +V +FALCWLPLH I+ + D + L L Y+ I + Sbjct: 363 LKQRREVAKTVFCLVLVFALCWLPLHLARILKLTLYNQNDPNRCELLSFLLVLDYIGINM 422 Query: 277 SHTNSVVNPFIYAYRIREFRQTFR 300 + NS NP + F+ F+ Sbjct: 423 ASLNSCANPIALYLVSKRFKNAFK 446 >5XSZ-A nrPDB Length = 477 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 68/157 (43%), Gaps = 6/157 (3%) Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT-- 65 +Y V + ++ ++ NV + + L+N T ++++L +D+ + VL +P + Sbjct: 30 LYSMVFSIVFMVGLITNVAAMYIFMCSLKLRNETTTYMMNLVVSDL-LFVLTLPLRVFYF 88 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 + + C SI L I++DR++AI P R GL T AK + Sbjct: 89 VQQNWPFGSLLCKLSVSLFYTNMYGSILFLTCISVDRFLAIVYPFRSRGLRTKRNAKIVC 148 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEG 162 A WVL + L N+ + +N+S C E Sbjct: 149 AAVWVLVLSGSLPTGFMLNSTNKL---ENNSISCFEN 182 >6DO1-A nrPDB Length = 425 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/120 (29%), Positives = 61/120 (50%), Gaps = 4/120 (3%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP-FAITISTGFC--A 72 I V+ I GN LV ++ L+ V + F+++LA AD+ +L +P +A+ + + Sbjct: 45 IFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCF-LLTLPLWAVYTAMEYRWPF 103 Query: 73 ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132 + C + V +S+F L ++IDRY+AI P++ T AK I W+L+ Sbjct: 104 GNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLA 163 >6AK3-B nrPDB Length = 418 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 51/234 (21%), Positives = 92/234 (39%), Gaps = 39/234 (16%) Query: 77 CLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIG 136 C F + V SS+F A+A++R +AIR P Y + + ++ W+ S A Sbjct: 92 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRITRAVLLGVWLASLAFA 151 Query: 137 LTPMLG-------------WNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183 L P+LG + + G+ +G + S G A F + + V F Sbjct: 152 LLPVLGVGQYTVQWPGTWCFISTGRGGQGTSSSHNWGNLFFASAFAFLGLLALTVT---F 208 Query: 184 ACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFA 243 +C L + ++ R + K SQ + R T + + L I+ + + Sbjct: 209 SCNLATIKALVD---------RCRAKATASQS-SAQWGRITTETAIQ----LMGIMLVLS 254 Query: 244 LCWLPLHIINCFTFF-------CPDCSHAPLW--LMYLAIVLSHTNSVVNPFIY 288 +CW PL I+ F C + +A+ L+ N +++P++Y Sbjct: 255 VCWSPLLIMMLKMIFQQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVY 308 >2LNL-A nrPDB Length = 309 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 80/324 (24%), Positives = 130/324 (40%), Gaps = 58/324 (17%) Query: 4 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63 + V I + +L++LGN LV + + ++VT+ ++++LA AD+ + +A Sbjct: 18 LNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWA 77 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 + G+ C ++ V S I L I++DRY+AI R T T+ + Sbjct: 78 ASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATR-----TLTQKRH 132 Query: 124 IIAI----CWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY 179 ++ CW LS + L P + P N S C E L D ++ Sbjct: 133 LVKFVCLGCWGLSMNLSL-PFFLFRQAYHP---NNSSPVCYE----VLGNDTAKWRMVLR 184 Query: 180 -----FNFFACVLVPLLLML---GVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHA 231 F F +VPL +ML G LR A G++ R A Sbjct: 185 ILPHTFGF----IVPLFVMLFCYGFTLRTLFKAHM-----------GQKHR--------A 221 Query: 232 AKSLAIIVGLFALCWLPLHII---------NCFTFFCPDCSHAPLWLMYLAIVLSHTNSV 282 + + +V +F LCWLP +++ C ++ L I L +S Sbjct: 222 MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEI-LGFLHSC 280 Query: 283 VNPFIYAYRIREFRQTFRKIIRSH 306 +NP IYA+ + FR F KI+ H Sbjct: 281 LNPIIYAFIGQNFRHGFLKILAMH 304 >6M9T-A nrPDB Length = 537 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 32/66 (48%) Query: 77 CLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIG 136 C F + V SS+F A+A++R +AIR P Y + + ++ W+ A Sbjct: 142 CTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFA 201 Query: 137 LTPMLG 142 L P+LG Sbjct: 202 LLPVLG 207 >4GRV-A nrPDB Length = 510 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 31/127 (24%), Positives = 57/127 (44%), Gaps = 18/127 (14%) Query: 72 AACHGCLFI--ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129 A C G F+ AC T ++ ++ ++++ RY+AI P + L++ +R K I+ W Sbjct: 108 AGCRGYYFLRDAC-----TYATALNVASLSVARYLAICHPFKAKTLMSRSRTKKFISAIW 162 Query: 130 VLS--FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACL-FEDVVPMNYMVYFNFFACV 186 + S AI + +G N + G G + C D + ++ N F Sbjct: 163 LASALLAIPMLFTMGLQN--------RSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSF 214 Query: 187 LVPLLLM 193 L P+L++ Sbjct: 215 LFPMLVI 221 Score = 34.7 bits (78), Expect = 0.069, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 33/71 (46%), Gaps = 12/71 (16%) Query: 238 IVGLFALCWLPLHI---INCF------TFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIY 288 +V F +CWLP H+ + C+ T F D H + L L++ +S +NP +Y Sbjct: 414 VVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYH---YFYMLTNALAYASSAINPILY 470 Query: 289 AYRIREFRQTF 299 FRQ F Sbjct: 471 NLVSANFRQVF 481 >5NJ6-A nrPDB Length = 437 Score = 35.4 bits (80), Expect = 0.049, Method: Compositional matrix adjust. Identities = 26/120 (21%), Positives = 55/120 (45%), Gaps = 3/120 (2%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDC 262 AA QLK + + S +K A K + ++ +C+ P +++ +F Sbjct: 305 AAAEQLKTTRNAYIQKYLENSE-KKRKRAIKLAVTVAAMYLICFTPSNLLLVVHYFLIKS 363 Query: 263 S-HAPLWLMYL-AIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTS 320 + ++ +Y+ A+ LS NS ++PF+Y + +FR + + +R + + + TS Sbjct: 364 QGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTS 423 >5NDD-A nrPDB Length = 619 Score = 35.0 bits (79), Expect = 0.061, Method: Compositional matrix adjust. Identities = 26/120 (21%), Positives = 55/120 (45%), Gaps = 3/120 (2%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDC 262 AA QLK + + S +K A K + ++ +C+ P +++ +F Sbjct: 487 AAAEQLKTTRNAYIQKYLENSE-KKRKRAIKLAVTVAAMYLICFTPSNLLLVVHYFLIKS 545 Query: 263 S-HAPLWLMYL-AIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTS 320 + ++ +Y+ A+ LS NS ++PF+Y + +FR + + +R + + + TS Sbjct: 546 QGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTS 605 >4XNV-A nrPDB Length = 421 Score = 35.0 bits (79), Expect = 0.068, Method: Compositional matrix adjust. Identities = 73/373 (19%), Positives = 136/373 (36%), Gaps = 62/373 (16%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP---FAITIST 68 V + + ++ LGN + W + + + ++ +LA AD + VL +P F T Sbjct: 56 VYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADF-LYVLTLPALIFYYFNKT 114 Query: 69 GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C V SI L I+ RY + PL+ G + A I + Sbjct: 115 DWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLV 174 Query: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF--NFFACV 186 W++ + ++P+L ++ G KN + C + D +Y +Y A Sbjct: 175 WLI-VVVAISPILFYSGTGV---RKNKTITCYDTT-----SDEYLRSYFIYSMCTTVAMF 225 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQ------------------------MESQPLPGE--- 219 VPL+L+LG Y I A ++K+ + + +P + Sbjct: 226 CVPLVLILGCYGLIVRALIYKMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVC 285 Query: 220 ------RARSTLQKEVHAAKSL---AIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLM 270 + + +E KS+ I++ +FA+ ++P H++ P Sbjct: 286 PLCGVGKDQFEEVEEPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCA 345 Query: 271 YLAIV---------LSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPF--KAAGT 319 + V L+ NS VNP +Y FR+ + R R + K+ Sbjct: 346 FNDRVYATYQVTRGLASLNSCVNPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDM 405 Query: 320 SARVLAAHGSDGE 332 + +L +G+ Sbjct: 406 TLNILPEFKQNGD 418 >5UIW-A nrPDB Length = 411 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 36/145 (24%), Positives = 60/145 (41%), Gaps = 31/145 (21%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHII---NCFTFF- 258 + Q +++E E+ R ++V ++ I+ LF W P +I+ N F F Sbjct: 269 VGKDQFEEVEE-----EKKR---HRDVRLIFTIMIVYFLF---WAPYNIVLLLNTFQEFF 317 Query: 259 -CPDCSHAPLW--LMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH-------VL 308 +CS + M + L T+ +NP IYA+ EFR + H + Sbjct: 318 GLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEEFRNYLLVFFQKHIFCKCCSIF 377 Query: 309 RQQEPFKAAGTSARVLAAHGSDGEQ 333 +Q+ P +A+ R S GEQ Sbjct: 378 QQEAPERASSVYTR------STGEQ 396 >3OE9-A nrPDB Length = 499 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 27/97 (27%), Positives = 50/97 (51%), Gaps = 2/97 (2%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF-AITISTG 69 T+ I + I+GN LV + L+++T+ + + L+ AD+ + V+ +PF A+ Sbjct: 53 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADL-LFVITLPFWAVDAVAN 111 Query: 70 FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAI 106 + C + V SS++ L I++DRY+AI Sbjct: 112 WYFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAI 148 >5LWE-A nrPDB Length = 331 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 2/91 (2%) Query: 22 LGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF-AITISTGFCAACHGCLFI 80 LGN LV W + + T+ F+++LA AD+ + ++ +PF AI + + C + Sbjct: 42 LGNSLVILVYWYCARAKTATDMFLLNLAIADL-LFLVTLPFWAIAAADQWKFQTFMCKVV 100 Query: 81 ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLR 111 + S + ++ I +DRYIAI +R Sbjct: 101 NSMYKMNFYSCVLLIMCICVDRYIAIAQAMR 131 >5WB1-A nrPDB Length = 458 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 3/93 (3%) Query: 22 LGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIA-VGVLAIPFAITISTGFCAACHGCLFI 80 +GN LV + + +Q + + ++LAAAD+ V L + + A+ L Sbjct: 57 IGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLT 116 Query: 81 ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYN 113 ACF + + S F + IA+DRY AI + +RY Sbjct: 117 ACFYVAMFASLCF-ITEIALDRYYAI-VYMRYR 147 >5X33-A nrPDB Length = 523 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 20/189 (10%) Query: 18 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI------TISTGFC 71 V+ + GN V W++ ++VT +V A +L PF + T S G Sbjct: 31 VVGLPGNTFVVWSILKRMRKRSVTA-LMVLNLALADLAVLLTAPFFLHFLTWGTWSFGL- 88 Query: 72 AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVL 131 A C C +I V +S+ + A+++DR +A+ P + T T A+ ++ W Sbjct: 89 AGCRLCHYICG---VSMYASVLLITAMSLDRSLAVASPFLSQKVRTKTAARWLLVGIWGA 145 Query: 132 SFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLL 191 SF + TP+L + + N + C ++ + + F F +VP L Sbjct: 146 SFLLA-TPVLAFRKVVKL---TNETDLC-----LAVYPSDRHKAFHLLFEAFTGFVVPFL 196 Query: 192 LMLGVYLRI 200 +++ Y I Sbjct: 197 IVVASYADI 205 >6AKX-A nrPDB Length = 381 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 29/121 (23%), Positives = 52/121 (42%), Gaps = 18/121 (14%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHII---NCFTFF- 258 + Q +++E E+ R ++V ++ I+ LF W P +I+ N F F Sbjct: 269 VGKDQFEEVEE-----EKKR---HRDVRLIFTIMIVYFLF---WAPYNIVLLLNTFQEFF 317 Query: 259 -CPDCSHAPLW--LMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFK 315 +CS + M + L T+ +NP IYA+ EFR + H+ ++ P + Sbjct: 318 GLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEEFRNYLLVFFQKHIAKRGRPLE 377 Query: 316 A 316 Sbjct: 378 V 378 >5T1A-A nrPDB Length = 508 Score = 32.3 bits (72), Expect = 0.43, Method: Compositional matrix adjust. Identities = 23/92 (25%), Positives = 40/92 (43%), Gaps = 9/92 (9%) Query: 227 KEVHAAKSLAIIVGLFALCWLPLHII---NCFTFF-----CPDCSHAPLWLMYLAIVLSH 278 +E A + + I+ ++ L W P +I+ N F F C S + L Sbjct: 408 REKKAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLD-QATQVTETLGM 466 Query: 279 TNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ 310 T+ +NP IYA+ +FR+ R H+ ++ Sbjct: 467 THCCINPIIYAFVGEKFRRYLSVFFRKHITKR 498 >4XT3-A nrPDB Length = 362 Score = 31.6 bits (70), Expect = 0.70, Method: Compositional matrix adjust. Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 3/93 (3%) Query: 22 LGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIA-VGVLAIPFAITISTGFCAACHGCLFI 80 +GN LV + + +Q + + ++LAAAD+ V L + + A+ L Sbjct: 57 IGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLT 116 Query: 81 ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYN 113 ACF + + S F + IA+DRY AI + +RY Sbjct: 117 ACFYVAMFASLCF-ITEIALDRYYAI-VYMRYR 147 >4NTJ-A nrPDB Length = 466 Score = 30.8 bits (68), Expect = 1.00, Method: Compositional matrix adjust. Identities = 18/75 (24%), Positives = 37/75 (49%), Gaps = 7/75 (9%) Query: 237 IIVGLFALCWLPLHIIN-----CFTFFCPDCS--HAPLWLMYLAIVLSHTNSVVNPFIYA 289 II+ +F +C++P H T DC+ + ++ + L+ N+ +NPFIY Sbjct: 355 IIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLNPFIYF 414 Query: 290 YRIREFRQTFRKIIR 304 + + FR + +++ Sbjct: 415 FLCKSFRNSLISMLK 429 >5ZKP-A nrPDB Length = 466 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 55/242 (22%), Positives = 93/242 (38%), Gaps = 30/242 (12%) Query: 9 YITVELAIAVLAILGNVLVCWAVWLNSNLQ-----NVTNYFVVSLAAADIAVGVLAIPFA 63 Y + +++ +LG + + +W+ + L N F+V+L AD+ + ++ +P Sbjct: 17 YTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADM-LFLITLPLW 75 Query: 64 IT--------ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGL 115 I I F GCLF + T S+ L I +RY A+ P++ Sbjct: 76 IVYYQNQGNWILPKFLCNVAGCLF-----FINTYCSVAFLGVITYNRYQAVTRPIKTAQA 130 Query: 116 VTGTRAKGIIAICWV-LSFAIGLTPMLGWNNCGQPKEGKNHSQGCGE----GQVACLFED 170 T R + + WV + A +L N G C E G V Sbjct: 131 NTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGDVTRCFEHYEKGSVP----- 185 Query: 171 VVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVH 230 V+ ++ + F+FF L+ L L V +R L + L S E T+ +E+ Sbjct: 186 VLIIHIFIVFSFFLVFLIILFCNL-VIIRTLLMQAKALIVYGSTTGNTEYTAETIARELA 244 Query: 231 AA 232 A Sbjct: 245 DA 246 >3VW7-A nrPDB Length = 484 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 27/101 (26%), Positives = 48/101 (47%), Gaps = 5/101 (4%) Query: 44 FVVSLAAADIAVGVLAIPFAITI---STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAI 100 +++ LA AD+ + V +PF I+ + + C F+ +SI + I+I Sbjct: 58 YMLHLATADV-LFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISI 116 Query: 101 DRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPML 141 DR++A+ P++ T RA W L+ A G+ P+L Sbjct: 117 DRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIA-GVVPLL 156 >4TW5-A nrPDB Length = 272 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 17/22 (77%), Gaps = 1/22 (4%) Query: 249 LHIINCFTFFCPDCSH-APLWL 269 LHII+ ++ +CP C H AP+W+ Sbjct: 27 LHIIDFYSPYCPHCKHLAPVWM 48 >6GPS-A nrPDB Length = 429 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 41/182 (22%), Positives = 66/182 (36%), Gaps = 40/182 (21%) Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHII---NCFTFF- 258 + Q +++E E+ R ++V ++ I+ LF W P +I+ N F F Sbjct: 274 VGKDQFEEVEE-----EKKR---HRDVRVIFTIMIVYFLF---WTPYNIVILLNTFQEFF 322 Query: 259 ----CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPF 314 C S + L T+ +NP IYA+ EFR F + + Q+P Sbjct: 323 GLSNCESTSQLD-QATQVTETLGMTHCCINPIIYAFVGEEFRSLFHIALGCRIAPLQKPV 381 Query: 315 KAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQES 374 G R G+ V + G G R G ++G S Q+ Sbjct: 382 -CGGPGVR-------PGKNVKVTTQGLLDG------------RGKGKSIGRAPEASLQDK 421 Query: 375 QG 376 +G Sbjct: 422 EG 423 >3KLY-A nrPDB Length = 280 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 30/52 (57%), Gaps = 11/52 (21%) Query: 19 LAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGF 70 L ++ N+LVC AVW+ + +++T+ V VL +P A+ +S+GF Sbjct: 166 LGLMCNILVCLAVWMTFSARSLTD-----------KVMVLILPVAMFVSSGF 206 >5ZKQ-A nrPDB Length = 438 Score = 28.9 bits (63), Expect = 4.0, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 94/246 (38%), Gaps = 34/246 (13%) Query: 9 YITVELAIAVLAILGNVLVCWAVWLNSNLQ-----NVTNYFVVSLAAADIAVGVLAIPFA 63 Y + +++ +LG + + +W+ + L N F+V+L AD+ + ++ +P Sbjct: 17 YTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADM-LFLITLPLW 75 Query: 64 IT--------ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGL 115 I I F GCLF + T S+ L I +RY A+ P++ Sbjct: 76 IVYYQNQGNWILPKFLCNVAGCLF-----FINTYCSVAFLGVITYNRYQAVTRPIKTAQA 130 Query: 116 VTGTRAKGIIAICWV-LSFAIGLTPMLGWNNCGQPKEGKNHSQGCGE----GQVACLFED 170 T R + + WV + A +L N G C E G V L Sbjct: 131 NTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGDVTRCFEHYEKGSVPVLI-- 188 Query: 171 VVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQM----ESQPLPGERARSTLQ 226 ++ + F+FF L+ L L V +R L + +M E G+ A Sbjct: 189 ---IHIFIVFSFFLVFLIILFCNL-VIIRTLLMQPVNIFEMLRIDEGGGSGGDEAEKLFN 244 Query: 227 KEVHAA 232 ++V AA Sbjct: 245 QDVDAA 250 >6D26-A nrPDB Length = 470 Score = 28.9 bits (63), Expect = 4.1, Method: Compositional matrix adjust. Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 16/91 (17%) Query: 245 CWLPLHIINCFTFFCPDCSHA-----PLWLMYLAIV--LSHTNSVVNPFIYAYR----IR 293 CW P H+ + +HA PL L V L+ NSV NP +Y +R Sbjct: 383 CWGPYHVFS----LLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLR 438 Query: 294 EFRQTFRKIIRSHVLRQQEPFKAAGTSARVL 324 + R++ R ++ S VL AG+S VL Sbjct: 439 KLRRSLRTVLES-VLVDDSELGGAGSSLEVL 468 >3NM7-A nrPDB Length = 127 Score = 28.5 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%) Query: 286 FIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSL 336 F+Y I EF K I V++Q+ + G+SAR +G GE+ L Sbjct: 58 FVYEENINEFESNLLKAIA--VIKQKVSTGSVGSSARHNKGYGEYGERSKL 106 >1D0M-A nrPDB Length = 322 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 14/35 (40%), Positives = 20/35 (57%), Gaps = 1/35 (2%) Query: 312 EPFKAAGTSARVLAAHG-SDGEQVSLRLNGHPPGV 345 +P A G+ A AHG G+QV++ NG PG+ Sbjct: 209 DPVDAIGSVANYFKAHGWVKGDQVAVMANGQAPGL 243 >6C1Q-B nrPDB Length = 422 Score = 27.7 bits (60), Expect = 9.8, Method: Compositional matrix adjust. Identities = 65/299 (21%), Positives = 107/299 (35%), Gaps = 45/299 (15%) Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACH 75 + ++ +LGN LV W + + + + ++LA AD + LA+P T Sbjct: 133 VFLVGVLGNALVVWVTAFEAK-RTINAIWFLNLAVADF-LSCLALPILFTSIVQHHHWPF 190 Query: 76 G---CLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132 G C + +L+ +SI L I+ DR++ + P+ A A+ W L+ Sbjct: 191 GGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLA 250 Query: 133 FAIGLTPMLG---WNNCGQPKE--GKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL 187 + + L PK G ++S + + V+ L Sbjct: 251 LLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGF------------L 298 Query: 188 VPLLLMLGVYLRIFLA--ARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 245 PLL + Y I L +RR R+ TL+ V S F + Sbjct: 299 WPLLTLTICYTFILLRTWSRR-----------ATRSTKTLKVVVAVVAS-------FFIF 340 Query: 246 WLPLHIINCFTFFCPDCSHAPLWLMYLA---IVLSHTNSVVNPFIYAYRIREFRQTFRK 301 WLP + F S L L L + ++ N +NP IY + F+ RK Sbjct: 341 WLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRK 399 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6GDG-A nrPDB 403 e-113 3PWH-A nrPDB 386 e-107 3SN6-R nrPDB 301 3e-82 5N2S-A nrPDB 291 3e-79 2R4S-A nrPDB 287 7e-78 4GBR-A nrPDB 283 1e-76 6IBL-A nrPDB 282 2e-76 5UVI-A nrPDB 280 1e-75 4LDO-A nrPDB 279 2e-75 5WF6-A nrPDB 273 1e-73 6D9H-R nrPDB 271 5e-73 2VT4-A nrPDB 268 3e-72 4MQS-A nrPDB 260 1e-69 6G79-S nrPDB 248 3e-66 4RWA-A nrPDB 236 1e-62 5DHG-A nrPDB 234 5e-62 6B73-A nrPDB 230 8e-61 6DDF-R nrPDB 226 1e-59 5ZBQ-A nrPDB 226 1e-59 5C1M-A nrPDB 219 2e-57 6ME9-A nrPDB 211 3e-55 5W0P-A nrPDB 210 7e-55 3P0G-A nrPDB 209 1e-54 5UEN-A nrPDB 208 3e-54 5DYS-A nrPDB 206 1e-53 6N4B-R nrPDB 206 2e-53 2KS9-A nrPDB 205 3e-53 4ZUD-A nrPDB 202 2e-52 6CMO-R nrPDB 201 3e-52 4U14-A nrPDB 191 4e-49 5VBL-B nrPDB 190 8e-49 4U15-A nrPDB 190 9e-49 4DKL-A nrPDB 187 8e-48 4IAR-A nrPDB 187 9e-48 5ZKB-A nrPDB 186 1e-47 3UON-A nrPDB 185 2e-47 5V54-A nrPDB 182 2e-46 3RZE-A nrPDB 182 3e-46 3AYN-A nrPDB 181 5e-46 4WW3-A nrPDB 179 2e-45 4XEE-A nrPDB 179 2e-45 6A94-A nrPDB 178 5e-45 6DRY-A nrPDB 178 5e-45 5DSG-A nrPDB 177 6e-45 4BWB-A nrPDB 176 2e-44 3PBL-A nrPDB 176 2e-44 4EJ4-A nrPDB 176 2e-44 6CM4-A nrPDB 174 4e-44 4DJH-A nrPDB 174 5e-44 5CXV-A nrPDB 173 1e-43 5WS3-A nrPDB 172 3e-43 4BUO-A nrPDB 170 9e-43 6BQH-A nrPDB 169 2e-42 5ZBH-A nrPDB 168 5e-42 4ZJC-A nrPDB 154 5e-38 5U09-A nrPDB 152 3e-37 5UNF-A nrPDB 151 8e-37 6J20-A nrPDB 145 2e-35 5XRA-A nrPDB 145 4e-35 5XSZ-A nrPDB 144 9e-35 3V2Y-A nrPDB 142 3e-34 5GLH-A nrPDB 141 6e-34 5GLI-A nrPDB 139 2e-33 5WIV-A nrPDB 135 2e-32 6HLP-A nrPDB 130 1e-30 5ZTY-A nrPDB 129 3e-30 4Z36-A nrPDB 123 1e-28 5XJM-A nrPDB 97 1e-20 Sequences not found previously or not previously below threshold: 6DO1-A nrPDB 156 1e-38 6GPS-A nrPDB 147 6e-36 2LNL-A nrPDB 142 2e-34 5UIW-A nrPDB 140 7e-34 6AKX-A nrPDB 139 2e-33 6GPX-A nrPDB 139 3e-33 6MET-B nrPDB 134 8e-32 4XNV-A nrPDB 134 9e-32 5LWE-A nrPDB 132 2e-31 6C1Q-B nrPDB 129 2e-30 5WB1-A nrPDB 123 1e-28 5T1A-A nrPDB 121 5e-28 4GRV-A nrPDB 120 7e-28 5O9H-A nrPDB 120 7e-28 4XT3-A nrPDB 119 2e-27 3VW7-A nrPDB 111 7e-25 3OE9-A nrPDB 108 4e-24 5X33-A nrPDB 99 4e-21 6AK3-B nrPDB 94 1e-19 5NDD-A nrPDB 93 2e-19 5NJ6-A nrPDB 91 1e-18 5ZKQ-A nrPDB 89 3e-18 5ZKP-A nrPDB 89 5e-18 6D26-A nrPDB 81 8e-16 4NTJ-A nrPDB 81 1e-15 5YWY-A nrPDB 79 4e-15 6M9T-A nrPDB 76 4e-14 4PHU-A nrPDB 64 1e-10 6IIU-A nrPDB 50 2e-06 2LOT-A nrPDB 34 0.12 5XEP-A nrPDB 32 0.45 2I9D-A nrPDB 30 2.0 6B3J-R nrPDB 29 5.1 1D0M-A nrPDB 29 5.5 5NX2-A nrPDB 28 8.8 >6GDG-A nrPDB Length = 479 Score = 403 bits (1035), Expect = e-113, Method: Composition-based stats. Identities = 308/312 (98%), Positives = 309/312 (99%) Query: 5 GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI 64 +VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI Sbjct: 168 AKAVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI 227 Query: 65 TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 124 TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI Sbjct: 228 TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 287 Query: 125 IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 IAICWVLSFAIGLTPMLGWNNCGQPKEGK HSQGCGEGQVACLFEDVVPMNYMVYFNFFA Sbjct: 288 IAICWVLSFAIGLTPMLGWNNCGQPKEGKAHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 347 Query: 185 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL 244 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL Sbjct: 348 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL 407 Query: 245 CWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 CWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR Sbjct: 408 CWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 467 Query: 305 SHVLRQQEPFKA 316 SHVLRQQEPFKA Sbjct: 468 SHVLRQQEPFKA 479 >3PWH-A nrPDB Length = 329 Score = 386 bits (991), Expect = e-107, Method: Composition-based stats. Identities = 307/315 (97%), Positives = 308/315 (97%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADI VGVLAI Sbjct: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADILVGVLAI 60 Query: 61 PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR 120 PFAITISTGFCAACHGCLFIACFVLVL QSSIFSLLAIAIDRYIAI IPLRYNGLVTGTR Sbjct: 61 PFAITISTGFCAACHGCLFIACFVLVLAQSSIFSLLAIAIDRYIAIAIPLRYNGLVTGTR 120 Query: 121 AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180 A GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF Sbjct: 121 AAGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180 Query: 181 NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG 240 NFFACVLVPLLLMLGVYLRIF AARRQLKQMESQPLPGERARSTLQKEVHAAKS AII G Sbjct: 181 NFFACVLVPLLLMLGVYLRIFAAARRQLKQMESQPLPGERARSTLQKEVHAAKSAAIIAG 240 Query: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVL+HTNSVVNPFIYAYRIREFRQTFR Sbjct: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLAHTNSVVNPFIYAYRIREFRQTFR 300 Query: 301 KIIRSHVLRQQEPFK 315 KIIRSHVLRQQEPFK Sbjct: 301 KIIRSHVLRQQEPFK 315 >3SN6-R nrPDB Length = 514 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 102/346 (29%), Positives = 165/346 (47%), Gaps = 40/346 (11%) Query: 10 ITVELAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITI 66 + + +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A + Sbjct: 185 MGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHIL 244 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + + C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II Sbjct: 245 TKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIIL 304 Query: 127 ICWVLSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 + W++S P+ + W + + C + C D + Sbjct: 305 MVWIVSGLTSFLPIQMHW-----YRATHQEAINCYAEETCC---DFFTNQAYAIASSIVS 356 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQM---------------ESQPLPGERARSTLQ---K 227 VPL++M+ VY R+F A+RQL+++ E G R + + K Sbjct: 357 FYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLK 416 Query: 228 EVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFI 287 E A K+L II+G F LCWLP I+N + ++++ + + NS NP I Sbjct: 417 EHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILL--NWIGYVNSGFNPLI 474 Query: 288 YAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQ 333 Y R +FR F++++ LR + KA G +++G+ GEQ Sbjct: 475 YC-RSPDFRIAFQELL---CLR-RSSLKAYGNG---YSSNGNTGEQ 512 >5N2S-A nrPDB Length = 436 Score = 291 bits (746), Expect = 3e-79, Method: Composition-based stats. Identities = 155/308 (50%), Positives = 198/308 (64%), Gaps = 3/308 (0%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT 65 + YI +E+ IA++++ GNVLV WAV +N L++ T F+VSLA AD+ VG L IP AI Sbjct: 116 QAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVLVGALVIPLAIL 175 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 I+ G H CL +AC VL+L QSSI +LLAIA+DRY+ ++IPLRY +VT RA I Sbjct: 176 INIGPQTYFHTCLMVACPVLILAQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAI 235 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 A CW+LSF +GLTPM GWNN + + GE + C FE V+ M YMVYFNFF Sbjct: 236 AGCWILSFVVGLTPMFGWNNLSAVERAWAAAGSMGEPVIKCEFEKVISMEYMVYFNFFVW 295 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 245 VL PLLLM+ +YL +F R+QL + S + KE+ AKS A+I LFAL Sbjct: 296 VLPPLLLMVLIYLEVFALIRKQLNKKVSA--SSGDPQKYYGKELKIAKSAALIAFLFALS 353 Query: 246 WLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 WLPLHI+NC T FCP C H P L Y+AI L+H NS +NP +YA+RI++FR TF KI Sbjct: 354 WLPLHILNCITLFCPSC-HKPSILTYIAIFLAHGNSAMNPIVYAFRIQKFRVTFLKIWND 412 Query: 306 HVLRQQEP 313 H Q P Sbjct: 413 HFRSQPAP 420 >2R4S-A nrPDB Length = 342 Score = 287 bits (734), Expect = 7e-78, Method: Composition-based stats. Identities = 102/346 (29%), Positives = 164/346 (47%), Gaps = 40/346 (11%) Query: 10 ITVELAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITI 66 + + +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A + Sbjct: 13 MGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHIL 72 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II Sbjct: 73 MKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIIL 132 Query: 127 ICWVLSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 + W++S P+ + W + + C + C D + Sbjct: 133 MVWIVSGLTSFLPIQMHW-----YRATHQEAINCYANETCC---DFFTNQAYAIASSIVS 184 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQM---------------ESQPLPGERARSTLQ---K 227 VPL++M+ VY R+F A+RQL+++ E G R + + K Sbjct: 185 FYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLK 244 Query: 228 EVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFI 287 E A K+L II+G F LCWLP I+N + ++++ + + NS NP I Sbjct: 245 EHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILL--NWIGYVNSGFNPLI 302 Query: 288 YAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQ 333 Y R +FR F++++ LR + KA G +++G+ GEQ Sbjct: 303 YC-RSPDFRIAFQELL---CLR-RSSLKAYGNG---YSSNGNTGEQ 340 >4GBR-A nrPDB Length = 309 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 100/328 (30%), Positives = 162/328 (49%), Gaps = 32/328 (9%) Query: 10 ITVELAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITI 66 + + +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A + Sbjct: 8 MGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHIL 67 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + + C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II Sbjct: 68 TKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIIL 127 Query: 127 ICWVLSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 + W++S P+ + W + + C + C D + Sbjct: 128 MVWIVSGLTSFLPIQMHW-----YRATHQEAINCYAEETCC---DFFTNQAYAIASSIVS 179 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 245 VPL++M+ VY R+F A+RQL++++ L KE A K+L II+G F LC Sbjct: 180 FYVPLVIMVFVYSRVFQEAKRQLQKIDKFCL----------KEHKALKTLGIIMGTFTLC 229 Query: 246 WLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 WLP I+N + ++++ + + NS NP IY R +FR F++++ Sbjct: 230 WLPFFIVNIVHVIQDNLIRKEVYILL--NWIGYVNSGFNPLIYC-RSPDFRIAFQELL-- 284 Query: 306 HVLRQQEPFKAAGTSARVLAAHGSDGEQ 333 LR + KA G +++G+ GEQ Sbjct: 285 -CLR-RSSLKAYGNG---YSSNGNTGEQ 307 >6IBL-A nrPDB Length = 416 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 99/302 (32%), Positives = 151/302 (50%), Gaps = 15/302 (4%) Query: 5 GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI 64 + V + + +L + GNVLV A+ LQ +TN F+ SLA AD+ VG+L +PF Sbjct: 111 AAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGA 170 Query: 65 TIS--TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 122 T+ + C ++ +SI +L IAIDRY+AI P RY L+T RAK Sbjct: 171 TLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAK 230 Query: 123 GIIAICWVLSFAIGLTP-MLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 II W +S + P M+ W P+ K C + C D V + Sbjct: 231 VIICTVWAISALVSFLPIMMHWWRDEDPQALK-----CYQDPGCC---DFVTNRAYAIAS 282 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGL 241 +PLL+M+ VYLR++ A+ Q+++++ + + +R KE A K+L II+G+ Sbjct: 283 SIISFYIPLLIMIFVYLRVYREAKEQIRKID-RASKRKTSRVMAMKEHKALKTLGIIMGV 341 Query: 242 FALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRK 301 F LCWLP ++N F D P WL L + NS +NP IY R +FR+ F++ Sbjct: 342 FTLCWLPFFLVNIVNVFNRDL--VPDWLFVAFNWLGYANSAMNPIIYC-RSPDFRKAFKR 398 Query: 302 II 303 ++ Sbjct: 399 LL 400 >5UVI-A nrPDB Length = 447 Score = 280 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 211/233 (90%), Positives = 216/233 (92%) Query: 2 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 61 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP Sbjct: 27 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 86 Query: 62 FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 121 FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA Sbjct: 87 FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 146 Query: 122 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN Sbjct: 147 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 206 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 FFACVLVPLLLMLGVYLRIFLAARRQL +E ++K +AA+ Sbjct: 207 FFACVLVPLLLMLGVYLRIFLAARRQLADLEDNWETLNDNLKVIEKADNAAQV 259 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 103/117 (88%), Positives = 105/117 (89%), Gaps = 2/117 (1%) Query: 202 LAARRQLKQMESQPLPG--ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFC 259 AA QLK + + ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFC Sbjct: 321 QAAAEQLKTTRNAYIQKYLERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFC 380 Query: 260 PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 316 PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA Sbjct: 381 PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 437 >4LDO-A nrPDB Length = 469 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 93/307 (30%), Positives = 151/307 (49%), Gaps = 28/307 (9%) Query: 10 ITVELAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITI 66 + + +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A + Sbjct: 185 MGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHIL 244 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + + C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II Sbjct: 245 TKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIIL 304 Query: 127 ICWVLSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 + W++S P+ + W + + C + C D + Sbjct: 305 MVWIVSGLTSFLPIQMHW-----YRATHQEAINCYAEETCC---DFFTNQAYAIASSIVS 356 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 245 VPL++M+ VY R+F A+RQL++++ L KE A K+L II+G F LC Sbjct: 357 FYVPLVIMVFVYSRVFQEAKRQLQKIDKFAL----------KEHKALKTLGIIMGTFTLC 406 Query: 246 WLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 WLP I+N + ++++ + + NS NP IY R +FR F++++ Sbjct: 407 WLPFFIVNIVHVIQDNLIRKEVYILL--NWIGYVNSGFNPLIYC-RSPDFRIAFQELL-- 461 Query: 306 HVLRQQE 312 LR+ Sbjct: 462 -CLRRSS 467 >5WF6-A nrPDB Length = 504 Score = 273 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 211/236 (89%), Positives = 217/236 (91%), Gaps = 1/236 (0%) Query: 2 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 61 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP Sbjct: 33 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 92 Query: 62 FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 121 FAITISTGFCAACHGCLFIACFVLVLTQS+IFSLLAIAIDRYIAIRIPLRYNGLVTGTRA Sbjct: 93 FAITISTGFCAACHGCLFIACFVLVLTQSAIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 152 Query: 122 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN Sbjct: 153 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 212 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 FFACVLVPLLLMLGVYLRIFLAARRQL E + E R + K+ ++ I Sbjct: 213 FFACVLVPLLLMLGVYLRIFLAARRQLNIFEMLRI-DEGLRLKIYKDTEGYYTIGI 267 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 98/120 (81%), Positives = 102/120 (85%), Gaps = 2/120 (1%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + RSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT Sbjct: 377 YNQTPNRAKRVITTFRTGTWDAY--RSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 434 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 316 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA Sbjct: 435 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 494 >6D9H-R nrPDB Length = 389 Score = 271 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 158/308 (51%), Positives = 202/308 (65%), Gaps = 3/308 (0%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT 65 + YI +E+ IA++++ GNVLV WAV +N L++ T F+VSLA AD+AVG L IP AI Sbjct: 64 QAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL 123 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 I+ G H CL +AC VL+LTQSSI +LLAIA+DRY+ ++IPLRY +VT RA I Sbjct: 124 INIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAI 183 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 A CW+LSF +GLTPM GWNN + + GE + C FE V+ M YMVYFNFF Sbjct: 184 AGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVW 243 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 245 VL PLLLM+ +YL +F R+QL + S + KE+ AKSLA+I+ LFAL Sbjct: 244 VLPPLLLMVLIYLEVFYLIRKQLNKKVSA--SSGDPQKYYGKELKIAKSLALILFLFALS 301 Query: 246 WLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 WLPLHI+NC T FCP C H P L Y+AI L+H NS +NP +YA+RI++FR TF KI Sbjct: 302 WLPLHILNCITLFCPSC-HKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWND 360 Query: 306 HVLRQQEP 313 H Q P Sbjct: 361 HFRCQPAP 368 >2VT4-A nrPDB Length = 313 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 98/297 (32%), Positives = 148/297 (49%), Gaps = 17/297 (5%) Query: 10 ITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS-- 67 + + +L + GNVLV A+ LQ +TN F+ SLA AD+ VG+L +PF T+ Sbjct: 15 SLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVR 74 Query: 68 TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAI 127 + C ++ +SI +L IAIDRY+AI P RY L+T RAK II Sbjct: 75 GTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICT 134 Query: 128 CWVLSFAIGLTP-MLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186 W +S + P M+ W P+ K C + C D V + Sbjct: 135 VWAISALVSFLPIMMHWWRDEDPQALK-----CYQDPGCC---DFVTNRAYAIASSIISF 186 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCW 246 +PLL+M+ V LR++ A+ Q+++++ +R R L +E A K+L II+G+F LCW Sbjct: 187 YIPLLIMIFVALRVYREAKEQIRKIDRA---SKRKRVMLMREHKALKTLGIIMGVFTLCW 243 Query: 247 LPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 LP ++N F D P WL L + NS +NP IY R +FR+ F++++ Sbjct: 244 LPFFLVNIVNVFNRDL--VPDWLFVAFNWLGYANSAMNPIIYC-RSPDFRKAFKRLL 297 >4MQS-A nrPDB Length = 351 Score = 260 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 141/305 (46%), Gaps = 19/305 (6%) Query: 9 YITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA--ITI 66 + V +++++ I+GN+LV ++ +N +LQ V NYF+ SLA AD+ +GV ++ T+ Sbjct: 43 IVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTV 102 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + C V++ +S+ +LL I+ DRY + PL Y T A +IA Sbjct: 103 IGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 162 Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186 WVLSF + +L W + ++ + + A Sbjct: 163 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYI----------QFFSNAAVTFGTAIAAF 212 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQ-----KEVHAAKSLAIIVGL 241 +P+++M +Y I A++ ++K+ + +P+ + ST + +E +++ I+ Sbjct: 213 YLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSTRKKPPPSREKKVTRTILAILLA 272 Query: 242 FALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRK 301 F + W P +++ FC C +W + L + NS +NP YA F++TF+ Sbjct: 273 FIITWAPYNVMVLINTFCAPCIPNTVW--TIGYWLCYINSTINPACYALCNATFKKTFKH 330 Query: 302 IIRSH 306 ++ H Sbjct: 331 LLMCH 335 >6G79-S nrPDB Length = 364 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 86/364 (23%), Positives = 140/364 (38%), Gaps = 70/364 (19%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA-- 63 + + + I + L N V V+ L NY + SLA D+ V +L +P + Sbjct: 17 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 76 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 T++ + C F + +SI+ L IA+DRY AI + Y+ T RA Sbjct: 77 YTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAV 136 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY--FN 181 +IA+ WV S +I L P W +E + E VV ++++Y ++ Sbjct: 137 MIALVWVFSISISLPP-FFWRQAKAEEE---------------VSECVVNTDHILYTVYS 180 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPG----------------------- 218 P LL++ +Y RI++ AR ++ + Sbjct: 181 TVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINS 240 Query: 219 ---------------------------ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHI 251 E+ + +E A K+L II+G F +CWLP I Sbjct: 241 RVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFI 300 Query: 252 INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQ 311 I+ C D L + L + NS++NP IY +F+Q F K+IR + Sbjct: 301 ISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTSEN 360 Query: 312 EPFK 315 F+ Sbjct: 361 LYFQ 364 >4RWA-A nrPDB Length = 411 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 125/310 (40%), Gaps = 21/310 (6%) Query: 3 IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF 62 + + + A+ + +LGNVLV + + + ++ TN ++ +LA AD A+ +PF Sbjct: 119 LALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALAD-ALATSTLPF 177 Query: 63 AI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR 120 + + C + +SIF+L +++DRYIA+ P++ T + Sbjct: 178 QSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAK 237 Query: 121 AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180 AK I WVL+ +G+ M+ G + Sbjct: 238 AKLINICIWVLASGVGVPIMVM--------AVTRPRDGAVVCMLQFPSPSWYWDTVTKIC 289 Query: 181 NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG 240 F +VP+L++ Y + L R ++ + + + ++VG Sbjct: 290 VFLFAFVVPILIITVCYGLMLLRLRSVRLLS--------GSKEKDRSLRRITRMVLVVVG 341 Query: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWL--MYLAIVLSHTNSVVNPFIYAYRIREFRQT 298 F +CW P+HI PL + ++L I L + NS +NP +YA+ F++ Sbjct: 342 AFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRC 401 Query: 299 FRKIIRSHVL 308 FR++ R Sbjct: 402 FRQLCRKPCG 411 >5DHG-A nrPDB Length = 424 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 138/319 (43%), Gaps = 30/319 (9%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 +P+ + + LA+ V +LGN LV + + ++ ++ TN ++ +LA AD V +L + Sbjct: 120 LPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTL 178 Query: 61 PFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 PF T + + C + +S F+L A+++DRY+AI P+R + T Sbjct: 179 PFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 238 Query: 119 TRAKGIIAICWVLSFAIGLT-PMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYM 177 ++A+ + W L+ +G+ ++G S + ++ CL E P +Y Sbjct: 239 SKAQAVNVAIWALASVVGVPVAIMG-------------SAQVEDEEIECLVEIPTPQDYW 285 Query: 178 ----VYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAK 233 F +VP+L++ Y + R + L G R + + + + Sbjct: 286 GPVFAICIFLFSFIVPVLVISVCYSLMIRRLR------GVRLLSGSREKDRNLRRI--TR 337 Query: 234 SLAIIVGLFALCWLPLHIINCFT-FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRI 292 + ++V +F CW P+ + S + ++ L + NS +NP +YA+ Sbjct: 338 LVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLD 397 Query: 293 REFRQTFRKIIRSHVLRQQ 311 F+ FRK + L + Sbjct: 398 ENFKACFRKFCCASALGRP 416 >6B73-A nrPDB Length = 418 Score = 230 bits (587), Expect = 8e-61, Method: Composition-based stats. Identities = 72/309 (23%), Positives = 138/309 (44%), Gaps = 27/309 (8%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 +P++ ++VY V V+ ++GN LV + + + ++ TN ++ +LA AD V + Sbjct: 118 IPVIITAVYSVV----FVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TM 172 Query: 61 PF--AITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 PF + + + C + +SIF+L +++DRYIA+ P++ T Sbjct: 173 PFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 232 Query: 119 TRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVV---PMN 175 +AK I W+LS ++G++ ++ G + + + F D Sbjct: 233 LKAKIINICIWLLSSSVGISAIV--------LGGTKVREDVDVIECSLQFPDDDYSWWDL 284 Query: 176 YMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSL 235 +M F ++P+L+++ Y + L + + L G R + + + + + Sbjct: 285 FMKICVFIFAFVIPVLIIIVCYTLMILRLKSV------RLLSGSREKDRNLRRI--TRLV 336 Query: 236 AIIVGLFALCWLPLHIINCFTFFC-PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIRE 294 ++V +F +CW P+HI S A L Y I L +TNS +NP +YA+ Sbjct: 337 LVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDEN 396 Query: 295 FRQTFRKII 303 F++ FR Sbjct: 397 FKRCFRDFC 405 >6DDF-R nrPDB Length = 356 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 131/308 (42%), Gaps = 25/308 (8%) Query: 2 PIMGSSVYIT-VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 P M +++ I + + V+ + GN LV + + + ++ TN ++ +LA AD A+ + Sbjct: 61 PSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTL 119 Query: 61 PFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 PF + + C + +SIF+L +++DRYIA+ P++ T Sbjct: 120 PFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTP 179 Query: 119 TRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMV 178 AK + W+LS AIGL M + QG + + N + Sbjct: 180 RNAKIVNVCNWILSSAIGLPVMFM--------ATTKYRQGSIDCTLTFSHPTWYWENLLK 231 Query: 179 YFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAII 238 F ++P+L++ Y + L +LK + E+ R+ + + ++ Sbjct: 232 ICVFIFAFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRNL----RRITRMVLVV 283 Query: 239 VGLFALCWLPLH---IINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREF 295 V +F +CW P+H II W + I L +TNS +NP +YA+ F Sbjct: 284 VAVFIVCWTPIHIYVIIKALITIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENF 341 Query: 296 RQTFRKII 303 ++ FR+ Sbjct: 342 KRCFREFC 349 >5ZBQ-A nrPDB Length = 525 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 140/322 (43%), Gaps = 22/322 (6%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 +P+ A+ +L + GN+ + + ++NVTN +V+L+ +D+ V ++ + Sbjct: 34 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL 93 Query: 61 PFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 PF T+ + C V SI+SL+ IA++R+ I P G Sbjct: 94 PFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIWSLVLIAVERHQLIINP---RGWRPN 150 Query: 119 TRAKGI-IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYM 177 R + IA+ WVL+ A L ++ +P +N + + + C F+ ++ Sbjct: 151 NRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPF--QNVTLDAYKDKYVC-FDQFPSDSHR 207 Query: 178 VYFNFFACVLV---PLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 + + VL PL + Y +I++ +R+ M+ + + RS+ K ++ Sbjct: 208 LSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDK--MRDNKYRSSETKRINI--M 263 Query: 235 LAIIVGLFALCWLPLHIINCF----TFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAY 290 L IV FA+CWLPL I N C+H L+L L + + ++ VNP Y + Sbjct: 264 LLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFL--LCHLTAMISTCVNPIFYGF 321 Query: 291 RIREFRQTFRKIIRSHVLRQQE 312 + F++ + R ++ Sbjct: 322 LNKNFQRDLQFFFNFCDFRSRD 343 >5C1M-A nrPDB Length = 296 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 129/304 (42%), Gaps = 25/304 (8%) Query: 2 PIMGSSVYIT-VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 P M +++ I + + V+ + GN LV + + + ++ TN ++ +LA AD A+ + Sbjct: 12 PSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTL 70 Query: 61 PFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 PF + + C + +SIF+L +++DRYIA+ P++ T Sbjct: 71 PFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTP 130 Query: 119 TRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMV 178 AK + W+LS AIGL M + QG + + N + Sbjct: 131 RNAKIVNVCNWILSSAIGLPVMFM--------ATTKYRQGSIDCTLTFSHPTWYWENLLK 182 Query: 179 YFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAII 238 F ++P+L++ Y + L +LK + E+ R+ + + ++ Sbjct: 183 ICVFIFAFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRNL----RRITRMVLVV 234 Query: 239 VGLFALCWLPLH---IINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREF 295 V +F +CW P+H II W + I L +TNS +NP +YA+ F Sbjct: 235 VAVFIVCWTPIHIYVIIKALITIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENF 292 Query: 296 RQTF 299 ++ F Sbjct: 293 KRCF 296 >6ME9-A nrPDB Length = 460 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 66/345 (19%), Positives = 126/345 (36%), Gaps = 56/345 (16%) Query: 2 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 61 P + V + + ++GN+LV +V N L+N N F+VSLA A++ V P Sbjct: 112 PSWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALANLVVAFYPYP 171 Query: 62 FAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGT 119 + G+ C A + + S++++ AIAIDRY+ I + Y+ + Sbjct: 172 LILVAIFYDGWAFGEEHCKASAFVMGLSVIGSVWNITAIAIDRYLYICHSMAYHRIYRRW 231 Query: 120 RAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY 179 I + W+L+ + L P + +C F Y Sbjct: 232 HTPLHICLIWLLT-VVALLPNFFVGSLEY-----------DPRIYSCTFIQTASTQYTAA 279 Query: 180 FNFFACVLVPLLLMLGVYLRIFLAA------------------------------RRQLK 209 L+P+ ++ YLRI++ K Sbjct: 280 VV-VIHFLLPIAVVSFCYLRIWVLVLQARMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFK 338 Query: 210 QMESQPLPG---------ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP 260 + + E ++ + ++ ++ +FA+C+ PL+ I P Sbjct: 339 DIPDDWVCPLCGVGKDQFEEVECLKPSDLRSFLTMFVVFVIFAICFAPLNCIGLAVAINP 398 Query: 261 D--CSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 P L + +L++ NS +NP +Y + FR+ +++I+ Sbjct: 399 QEMAPQIPEGLFVTSYLLAYFNSCLNPIVYGLLDQNFRREYKRIL 443 >5W0P-A nrPDB Length = 906 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 126/308 (40%), Gaps = 22/308 (7%) Query: 9 YITVELAIAVLAILG---NVLVCWAVWLNSNLQNVTNYFVVSLAAADI--AVGVLAIPFA 63 + + + +L +LG N L + + L+ NY +++LA AD+ +G Sbjct: 197 FSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLY 256 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 ++ F GC F + + +++SL+ +AI+RY+ + P+ N A Sbjct: 257 TSLHGYFVFGPTGCNLQGFFATLGGEIALWSLVVLAIERYVVVCKPMS-NFRFGENHAIM 315 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183 +A WV++ A P+ GW+ EG S G L +V ++++Y F Sbjct: 316 GVAFTWVMALACAAPPLAGWSRY--IPEGLQCSCGID---YYTLKPEVNNESFVIYM-FV 369 Query: 184 ACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFA 243 +P++++ Y ++ + Q + + +T + E + + I V F Sbjct: 370 VHFTIPMIIIFFCYGQLVFTVKEAAAQQ-------QESATTQKAEKEVTRMVIIYVIAFL 422 Query: 244 LCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 +CW+P + + F P++ M + + + ++ NP IY ++FR I Sbjct: 423 ICWVPYASVAFYIFTHQGSCFGPIF-MTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTI 481 Query: 304 RSHVLRQQ 311 + Sbjct: 482 --CCGKNP 487 >3P0G-A nrPDB Length = 501 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 69/232 (29%), Positives = 111/232 (47%), Gaps = 13/232 (5%) Query: 10 ITVELAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITI 66 + + +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A + Sbjct: 44 MGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHIL 103 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II Sbjct: 104 MKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIIL 163 Query: 127 ICWVLSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 + W++S P+ + W + + C + C D + Sbjct: 164 MVWIVSGLTSFLPIQMHW-----YRATHQEAINCYAEETCC---DFFTNQAYAIASSIVS 215 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 VPL++M+ VY R+F A+RQL E + E R + K+ ++ I Sbjct: 216 FYVPLVIMVFVYSRVFQEAKRQLNIFEMLRI-DEGLRLKIYKDTEGYYTIGI 266 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 13/137 (9%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + KE A K+L II+G F LCWLP I+N Sbjct: 376 YNQTPNRAKRVITTFRTGTWDAYK---FCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVH 432 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 316 + ++++ + + NS NP IY R +FR F++++ LR + KA Sbjct: 433 VIQDNLIRKEVYILL--NWIGYVNSGFNPLIYC-RSPDFRIAFQELL---CLR-RSSLKA 485 Query: 317 AGTSARVLAAHGSDGEQ 333 G +++G+ GEQ Sbjct: 486 YGNG---YSSNGNTGEQ 499 >5UEN-A nrPDB Length = 416 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 111/229 (48%), Positives = 147/229 (64%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT 65 + YI +E+ IA++++ GNVLV WAV +N L++ T F+VSLA AD+AVG L IP AI Sbjct: 10 QAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL 69 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 I+ G H CL +AC VL+LTQSSI +LLAIA+DRY+ ++IPLRY +VT RA I Sbjct: 70 INIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAI 129 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 A CW+LSF +GLTPM GWNN + + GE + C FE V+ M YMVYFNFF Sbjct: 130 AGCWILSFVVGLTPMFGWNNLSAVERAWAAAGSMGEPVIKCEFEKVISMEYMVYFNFFVW 189 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 VL PLLLM+ +YL +F R+QL +E ++K +AA+ Sbjct: 190 VLPPLLLMVLIYLEVFYLIRKQLADLEDNWETLNDNLKVIEKADNAAQV 238 Score = 97.5 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 62/112 (55%), Positives = 75/112 (66%), Gaps = 3/112 (2%) Query: 202 LAARRQLKQMESQPLPG--ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFC 259 AA QLK + + ERARSTLQKE+ AKSLA+I+ LFAL WLPLHI+NC T FC Sbjct: 300 QAAAEQLKTTRNAYIQKYLERARSTLQKELKIAKSLALILFLFALSWLPLHILNCITLFC 359 Query: 260 PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQ 311 P C H P L Y+AI L+H NS +NP +YA+RI++FR TF KI H Q Sbjct: 360 PSC-HKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQP 410 >5DYS-A nrPDB Length = 349 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 128/308 (41%), Gaps = 22/308 (7%) Query: 9 YITVELAIAVLAILG---NVLVCWAVWLNSNLQNVTNYFVVSLAAADI--AVGVLAIPFA 63 + + + +L +LG N L + + L+ NY +++LA AD+ G Sbjct: 38 FSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTILY 97 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 ++ F GC F + + +++SL+ +AI+RY+ + P+ N A Sbjct: 98 TSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMS-NFRFGENHAIM 156 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183 +A WV++ A P++GW+ EG S G E+ ++++Y F Sbjct: 157 GVAFTWVMALACAAPPLVGWSRY--IPEGMQCSCGID---YYTPHEETNNESFVIYM-FV 210 Query: 184 ACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFA 243 ++PL+++ Y ++ + Q + + +T + E + + I+V F Sbjct: 211 VHFIIPLIVIFFCYGQLVFTVKEAAAQQ-------QESATTQKAEKEVTRMVIIMVIAFL 263 Query: 244 LCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 +CWLP + + F P++ M + + T++V NP IY ++FR + Sbjct: 264 ICWLPYAGVAFYIFTHQGSCFGPIF-MTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTL 322 Query: 304 RSHVLRQQ 311 + Sbjct: 323 --CCGKNP 328 >6N4B-R nrPDB Length = 495 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 86/345 (24%), Positives = 136/345 (39%), Gaps = 34/345 (9%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNY-FVVSLAAADIAVGVLAIPFAI 64 + L + +L N+LV + + +L+ +Y F+ SLA AD+ V+ + I Sbjct: 131 QLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFI 190 Query: 65 TISTGFCAACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 LF V +S+ SL AIDRYI+I PL Y +VT +A Sbjct: 191 DFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVV 250 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183 + W ++ I + P+LGWN C + Q C D+ P Y F+ Sbjct: 251 AFCLMWTIAIVIAVLPLLGWN--------------CEKLQSVC--SDIFPHIDETYLMFW 294 Query: 184 ACVL-VPLLLMLGVYLRIFLAARRQLKQMESQPL-------PGERAR------STLQKEV 229 V V LL ++ Y+ I A +M + E + + ++ Sbjct: 295 IGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDI 354 Query: 230 HAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYA 289 AK+L +I+ + +CW PL I + F + +L NS VNP IYA Sbjct: 355 RLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAF-CSMLCLLNSTVNPIIYA 413 Query: 290 YRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQV 334 R ++ R FR + S Q P + + L H ++ V Sbjct: 414 LRSKDLRHAFRSMFPSCEGTAQ-PLDNSMGDSDCLHKHANNAASV 457 >2KS9-A nrPDB Length = 364 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 76/322 (23%), Positives = 132/322 (40%), Gaps = 48/322 (14%) Query: 28 CWAVWLNSNLQNVTNYFVVSLAAADIAVGVL--AIPFAITISTGFCAACHGCLFIACFVL 85 W + + ++ VTNYF+V+LA A+ ++ + F + + C F F + Sbjct: 54 MWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPI 113 Query: 86 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNN 145 +SI+S+ A+A DRY+AI PL+ ++ T K +I + WVL+ + Sbjct: 114 AAVFASIYSMTAVAFDRYMAIIHPLQ--PRLSATATKVVICVIWVLALLLAFP------- 164 Query: 146 CGQPKEGKNHSQGCGEGQVACLFEDV-----VPMNYMVYFNFFACVLVPLLLMLGVYLRI 200 +G + +V C+ E + +PLL++ Y + Sbjct: 165 -----QGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVV 219 Query: 201 FLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG----LFALCWLPLHIINCFT 256 + + + +PG + ++V A + + ++ FA+CWLP HI Sbjct: 220 GIT-------LWASEIPG-DSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLP 271 Query: 257 FFCPDCSHAP-LWLMYLAI-VLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPF 314 + PD + +YLAI L+ ++++ NP IY FR F+ R PF Sbjct: 272 YINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCC------PF 325 Query: 315 KAAG-------TSARVLAAHGS 329 +AG S R L GS Sbjct: 326 ISAGDYEGLEMKSTRYLQTQGS 347 >4ZUD-A nrPDB Length = 410 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 120/301 (39%), Gaps = 28/301 (9%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--- 67 T+ I V+ I GN LV ++ L+ V + F+++LA AD+ +L +P + Sbjct: 128 TLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCF-LLTLPLWAVYTAME 186 Query: 68 TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAI 127 + + C + V +S+F L ++IDRY+AI P++ T AK I Sbjct: 187 YRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCII 246 Query: 128 CWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL 187 W+L+ L ++ N E Q + L + L Sbjct: 247 IWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTL------PIGLGLTKNILGFL 300 Query: 188 VPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWL 247 P L++L Y I+ A ++ + +++P + K + IV F W+ Sbjct: 301 FPFLIILTSYTLIWKALKKAYEIQKNKP-----------RNDDIFKIIMAIVLFFFFSWI 349 Query: 248 PLHIINCFTFFCP-----DCSHAPLW--LMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300 P I DC A + M + I +++ N+ +NP Y + ++F++ F Sbjct: 350 PHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFL 409 Query: 301 K 301 + Sbjct: 410 Q 410 >6CMO-R nrPDB Length = 463 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 125/302 (41%), Gaps = 20/302 (6%) Query: 9 YITVELAIAVLAILG---NVLVCWAVWLNSNLQNVTNYFVVSLAAADI--AVGVLAIPFA 63 + + + +L +LG N L + + L+ NY +++LA AD+ +G Sbjct: 177 FSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLY 236 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 ++ F GC F + + +++SL+ +AI+RY+ + P+ N A Sbjct: 237 TSLHGYFVFGPTGCNLQGFFATLGGEIALWSLVVLAIERYVVVCKPMS-NFRFGENHAIM 295 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183 +A WV++ A P+ GW+ EG S G L +V ++++Y F Sbjct: 296 GVAFTWVMALACAAPPLAGWSRY--IPEGLQCSCGID---YYTLKPEVNNESFVIYM-FV 349 Query: 184 ACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFA 243 +P++++ Y ++ + Q + + +T + E + + I V F Sbjct: 350 VHFTIPMIIIFFCYGQLVFTVKEAAAQQ-------QESATTQKAEKEVTRMVIIYVIAFL 402 Query: 244 LCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 +CW+P + + F P++ M + + + ++ NP IY ++FR I Sbjct: 403 ICWVPYASVAFYIFTHQGSCFGPIF-MTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTI 461 Query: 304 RS 305 Sbjct: 462 CC 463 >4U14-A nrPDB Length = 460 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 64/243 (26%), Positives = 110/243 (45%), Gaps = 19/243 (7%) Query: 2 PIMGSSVYITVELA-----IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVG 56 P+ G +++ V +A +A++ I+GN+LV A +N L+ V NYF++SLA AD+ +G Sbjct: 3 PLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIG 62 Query: 57 VLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNG 114 V+++ T I + C V + +S+ +LL I+ DRY +I PL Y Sbjct: 63 VISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRA 122 Query: 115 LVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPM 174 T RA +I + WV+SF + +L W + GE + L E + Sbjct: 123 KRTTKRAGVMIGLAWVISFVLWAPAILFWQ-----YFVGKRTVPPGECFIQFLSEPTIT- 176 Query: 175 NYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 + A +P+ +M +Y RI+ + E + E R + K+ + Sbjct: 177 ----FGTAIAAFYMPVTIMTILYWRIYKETEKM-NCFEMLRI-DEGLRLKIYKDCEGYYT 230 Query: 235 LAI 237 + I Sbjct: 231 IGI 233 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 2/81 (2%) Query: 227 KEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPF 286 KE AA++L+ I+ F + W P +I+ FC C W L L + NS VNP Sbjct: 368 KEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYW--NLGYWLCYINSTVNPV 425 Query: 287 IYAYRIREFRQTFRKIIRSHV 307 YA + FR TF+ ++ Sbjct: 426 CYALCNKTFRTTFKTLLLCQC 446 >5VBL-B nrPDB Length = 407 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 67/339 (19%), Positives = 126/339 (37%), Gaps = 44/339 (12%) Query: 7 SVYITVELAIAVLAILGNVLVCWAVWLNSNL-QNVTNYFVVSLAAADIAVGVLAIPFAIT 65 ++ + + + +L GN LV W V+ +S + + F+ SLA AD+ V+ +P T Sbjct: 47 ALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTF-VVTLPLWAT 105 Query: 66 ISTG---FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 122 + + C + + V +S F L ++ DRY+AI P+ L Sbjct: 106 YTYRDYDWPFGTFFCKLSSYLIFVNMYASAFCLTGLSFDRYLAIVRPVANARLRLRVSGA 165 Query: 123 GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182 A+ WVL+ + + P++ G + VA + + + + Sbjct: 166 VATAVLWVLAALLAM-PVMVLRTTGDLENTNKVQCYMDYSMVATVSSEWAWEVGLGVSST 224 Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQ----------------------MESQPLPGER 220 +VP +ML Y I + + + +P + Sbjct: 225 TVGFVVPFTIMLTCYFFIAQTIAMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDW 284 Query: 221 -------ARSTLQKEVHAAKSLAIIVGL---FALCWLPLHIINCFTFFCPDCSHAPLWLM 270 + ++ + L+IIV L FALC +P H++ + + Sbjct: 285 VCPLCGVGKDQFEEVEERRRLLSIIVVLVVTFALCKMPYHLVKTLYMLGSLLHWPCDFDL 344 Query: 271 YL------AIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 +L +S+ NS +NPF+YA+ FRQ ++ Sbjct: 345 FLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSML 383 >4U15-A nrPDB Length = 418 Score = 190 bits (483), Expect = 9e-49, Method: Composition-based stats. Identities = 66/243 (27%), Positives = 111/243 (45%), Gaps = 22/243 (9%) Query: 2 PIMGSSVYITVELA-----IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVG 56 P+ G +++ V +A +A++ I+GN+LV A +N L+ V NYF++SLA AD+ +G Sbjct: 3 PLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIG 62 Query: 57 VLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNG 114 V+++ T I + C V + +S+ +LL I+ DRY +I PL Y Sbjct: 63 VISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRA 122 Query: 115 LVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPM 174 T RA +I + WV+SF + +L W + GE + L E + Sbjct: 123 KRTTKRAGVMIGLAWVISFVLWAPAILFWQ-----YFVGKRTVPPGECFIQFLSEPTIT- 176 Query: 175 NYMVYFNFFACVLVPLLLMLGVYLRIFLAARR-----QLKQMESQPLPGERARSTLQKEV 229 + A +P+ +M +Y RI+ + L+ E G+ A ++V Sbjct: 177 ----FGTAIAAFYMPVTIMTILYWRIYKETEKMNIFEMLRIDEGGGSGGDEAEKLFNQDV 232 Query: 230 HAA 232 AA Sbjct: 233 DAA 235 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 31/111 (27%), Positives = 47/111 (42%), Gaps = 7/111 (6%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + L KE AA++L+ I+ F + W P +I+ Sbjct: 300 YNQTPNRAKRVITTFRTGTWDAY-----LIKEKKAAQTLSAILLAFIITWTPYNIMVLVN 354 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHV 307 FC C W L L + NS VNP YA + FR TF+ ++ Sbjct: 355 TFCDSCIPKTYW--NLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQC 403 >4DKL-A nrPDB Length = 464 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 52/239 (21%), Positives = 97/239 (40%), Gaps = 13/239 (5%) Query: 2 PIMGSSVYIT-VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 P M +++ I + + V+ + GN LV + + + ++ TN ++ +LA AD A+ + Sbjct: 12 PSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTL 70 Query: 61 PFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 PF + + C + +SIF+L +++DRYIA+ P++ T Sbjct: 71 PFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTP 130 Query: 119 TRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMV 178 AK + W+LS AIGL M + QG + + N + Sbjct: 131 RNAKIVNVCNWILSSAIGLPVMFM--------ATTKYRQGSIDCTLTFSHPTWYWENLLK 182 Query: 179 YFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 F ++P+L++ Y + L + E + E R + K ++ I Sbjct: 183 ICVFIFAFIMPVLIITVCYGLMILRLKSVRNIFEMLRI-DEGLRLKIYKNTEGYYTIGI 240 Score = 71.3 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 25/120 (20%), Positives = 47/120 (39%), Gaps = 8/120 (6%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHI---IN 253 Y + A+R + + + + + ++V +F +CW P+HI I Sbjct: 350 YNQTPNRAKRVITTFRTGTWDAYEKD---RNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 406 Query: 254 CFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEP 313 W + I L +TNS +NP +YA+ F++ FR+ ++P Sbjct: 407 ALITIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQP 464 >4IAR-A nrPDB Length = 401 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 58/233 (24%), Positives = 100/233 (42%), Gaps = 20/233 (8%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA-- 63 + + + I + L N V V+ L NY + SLA D+ V +L +P + Sbjct: 20 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 79 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 T++ + C F + +SI+ L IA+DRY AI + Y+ T RA Sbjct: 80 YTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAV 139 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY--FN 181 +IA+ WV S +I L P W +E + E VV ++++Y ++ Sbjct: 140 MIALVWVFSISISLPP-FFWRQAKAEEE---------------VSECVVNTDHILYTVYS 183 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 P LL++ +Y RI++ AR ++ +E ++K +AA+ Sbjct: 184 TVGAFYFPTLLLIALYGRIYVEARSRIADLEDNWETLNDNLKVIEKADNAAQV 236 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 35/106 (33%), Positives = 49/106 (46%), Gaps = 4/106 (3%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD 261 AA QLK + + +E A K+L II+G F +CWLP II+ C D Sbjct: 298 QAAAEQLKTTRNAYIQKY----LAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKD 353 Query: 262 CSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHV 307 L + L + NS++NP IY +F+Q F K+IR Sbjct: 354 ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKC 399 >5ZKB-A nrPDB Length = 421 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 53/228 (23%), Positives = 101/228 (44%), Gaps = 12/228 (5%) Query: 9 YITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA--ITI 66 + V +++++ I+GN+LV ++ +N +LQ V NYF+ SLA AD+ +GV ++ T+ Sbjct: 28 IVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTV 87 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + C V++ + + +LL I+ DRY + PL Y T A +IA Sbjct: 88 IGYWPLGPVVCDLWLALDYVVSNARVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 147 Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186 WVLSF + +L W + ++ + + A Sbjct: 148 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYI----------QFFSNAAVTFGTAIAAF 197 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 +P+++M +Y I A++ ++ +E ++K +AA+ Sbjct: 198 YLPVIIMTVLYWHISRASKSRIADLEDNWETLNDNLKVIEKADNAAQV 245 Score = 99.0 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 25/105 (23%), Positives = 46/105 (43%), Gaps = 4/105 (3%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD 261 AA QLK + + + +E +++ I+ F + W P +++ FC Sbjct: 307 QAAAEQLKTTRNAYIQKYLPPPS--REKKVTRTILAILLAFIITWAPYNVMVLINTFCAP 364 Query: 262 CSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH 306 C +W + L + NS +NP YA F++TF+ ++ H Sbjct: 365 CIPNTVW--TIGYWLCYINSTINPACYALCNATFKKTFKHLLMCH 407 >3UON-A nrPDB Length = 467 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 55/231 (23%), Positives = 103/231 (44%), Gaps = 13/231 (5%) Query: 9 YITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA--ITI 66 + V +++++ I+GN+LV ++ +N +LQ V NYF+ SLA AD+ +GV ++ T+ Sbjct: 26 IVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTV 85 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + C V++ +S+ +LL I+ DRY + PL Y T A +IA Sbjct: 86 IGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145 Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186 WVLSF + +L W + ++ + + A Sbjct: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYI----------QFFSNAAVTFGTAIAAF 195 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 +P+++M +Y I A++ ++ E + E R + K+ ++ I Sbjct: 196 YLPVIIMTVLYWHISRASKSRINIFEMLRI-DEGLRLKIYKDTEGYYTIGI 245 Score = 96.3 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 45/110 (40%), Gaps = 5/110 (4%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + S E +++ I+ F + W P +++ Sbjct: 355 YNQTPNRAKRVITTFRTGTWDAYPPPSR---EKKVTRTILAILLAFIITWAPYNVMVLIN 411 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH 306 FC C +W + L + NS +NP YA F++TF+ ++ H Sbjct: 412 TFCAPCIPNTVW--TIGYWLCYINSTINPACYALCNATFKKTFKHLLMCH 459 >5V54-A nrPDB Length = 395 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 58/233 (24%), Positives = 102/233 (43%), Gaps = 20/233 (8%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA-- 63 + + + I + L N V V+ L NY + SLA D+ V +L +P + Sbjct: 13 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 72 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 T++ + C F + +SI+ L IA+DRY AI + Y+ T RA Sbjct: 73 YTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAV 132 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY--FN 181 +IA+ WV S +I L P W +E + E VV ++++Y ++ Sbjct: 133 MIALVWVFSISISLPP-FFWRQAKAEEE---------------VSECVVNTDHILYTVYS 176 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 P LL++ +Y RI++ AR ++ +E + E +++ +AA+ Sbjct: 177 TVGAFYFPTLLLIALYGRIYVEARSRIADLEDRWRTLEDNLRVIERAANAAEV 229 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 3/100 (3%) Query: 208 LKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPL 267 L+ + + +E A K+L II+G F +CWLP II+ C D L Sbjct: 297 LRTTRNAYIQKY---LMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHL 353 Query: 268 WLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHV 307 + L + NS++NP IY +F+Q F K+IR Sbjct: 354 AIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKC 393 >3RZE-A nrPDB Length = 452 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 69/231 (29%), Positives = 106/231 (45%), Gaps = 13/231 (5%) Query: 9 YITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--I 66 + V I ++ + N+LV +AV L V N ++VSL+ AD+ VG + +P I + Sbjct: 11 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 70 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 + + CLF V + +SIFS+ + IDRY +++ PLRY T TRA I Sbjct: 71 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 130 Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186 W LSF + + P+LGWN+ Q + E + F DV M Sbjct: 131 GAWFLSF-LWVIPILGWNHFMQQTSVRR------EDKCETDFYDVTWFKVMTA---IINF 180 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 +P LLML Y +I+ A R+ E + E R + K+ ++ I Sbjct: 181 YLPTLLMLWFYAKIYKAVRQHCNIFEMLRI-DEGLRLKIYKDTEGYYTIGI 230 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 31/107 (28%), Positives = 49/107 (45%), Gaps = 5/107 (4%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + +E AAK L I+ F LCW+P I Sbjct: 340 YNQTPNRAKRVITTFRTGTWDAY---LHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVI 396 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 FC +C + L + I L + NS +NP IY F++TF++I+ Sbjct: 397 AFCKNCCNEHLHMF--TIWLGYINSTLNPLIYPLCNENFKKTFKRIL 441 >3AYN-A nrPDB Length = 448 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 55/284 (19%), Positives = 100/284 (35%), Gaps = 17/284 (5%) Query: 29 WAVWLNSNLQNVTNYFVVSLAAADI---AVGVLAIPFAITISTGFCAACHGCLFIACFVL 85 + +LQ N F+++LA +D V + + C Sbjct: 57 YLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWIFGFAACKVYGFIGG 116 Query: 86 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNN 145 + SI ++ I+IDRY I P+ + ++ RA +I W+ S + P+ GW Sbjct: 117 IFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGA 176 Query: 146 CGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAAR 205 N S + F P+L++ Y I ++ Sbjct: 177 YTLEGVLCNCSFDYISRDSTTRSN--------ILCMFILGFFGPILIIFFCYFNIVMSVS 228 Query: 206 RQLKQM-----ESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP 260 K+M +A++ E+ AK +IV F L W P ++ F P Sbjct: 229 NHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGP 288 Query: 261 DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 P + L ++ + +++ NP IY+ +FR+ + Sbjct: 289 LEWVTP-YAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFP 331 >4WW3-A nrPDB Length = 350 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 55/284 (19%), Positives = 100/284 (35%), Gaps = 17/284 (5%) Query: 29 WAVWLNSNLQNVTNYFVVSLAAADI---AVGVLAIPFAITISTGFCAACHGCLFIACFVL 85 + +LQ N F+++LA +D V + + C Sbjct: 49 YLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWIFGFAACKVYGFIGG 108 Query: 86 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNN 145 + SI ++ I+IDRY I P+ + ++ RA +I W+ S + P+ GW Sbjct: 109 IFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGA 168 Query: 146 CGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAAR 205 N S + F P+L++ Y I ++ Sbjct: 169 YTLEGVLCNCSFDYISRDSTTRSN--------ILCMFILGFFGPILIIFFCYFNIVMSVS 220 Query: 206 RQLKQM-----ESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP 260 K+M +A++ E+ AK +IV F L W P ++ F P Sbjct: 221 NHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGP 280 Query: 261 DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 P + L ++ + +++ NP IY+ +FR+ + Sbjct: 281 LEWVTP-YAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFP 323 >4XEE-A nrPDB Length = 541 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 72/366 (19%), Positives = 136/366 (37%), Gaps = 47/366 (12%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTN---YFVVSLAAADIAVGVLAIPF 62 + + LA+ V+ +GN + + + +LQ++ + Y + SLA +D+ + +LA+P Sbjct: 32 KVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPV 91 Query: 63 AIT----ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 + + + GC T ++ ++ +++++RY+AI P + L++ Sbjct: 92 ELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSR 151 Query: 119 TRAKGIIAICWVLS--FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACL-FEDVVPMN 175 +R K I+ W+ S AI + +G N + G G + C D + Sbjct: 152 SRTKKFISAIWLASALLAIPMLFTMGLQN--------RSADGTHPGGLVCTPIVDTATVK 203 Query: 176 YMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERA----------RSTL 225 ++ N F L P+L++ + +L M Q R ST Sbjct: 204 VVIQVNTFMSFLFPMLVISI----LNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTF 259 Query: 226 QKEV---------HAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPL------WLM 270 + H L +V F +CWLP H+ + D + Sbjct: 260 NMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFY 319 Query: 271 YLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSD 330 L L + +S +NP +Y FRQ F + + KA G+ Sbjct: 320 MLTNALFYASSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKAHHHHHHHHHHGGNI 379 Query: 331 GEQVSL 336 E + + Sbjct: 380 FEMLRI 385 >6A94-A nrPDB Length = 376 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 57/224 (25%), Positives = 101/224 (45%), Gaps = 19/224 (8%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP---FAITISTGFC 71 + +L I GN+LV AV L LQN TNYF++SLA AD+ +G L +P I + Sbjct: 17 VVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWP 76 Query: 72 AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVL 131 C ++ + + I+ L AI++DRY+AI+ P+ ++ + T+A I W + Sbjct: 77 LPSKLCAVWIYLDVLFSTAKIWHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTI 136 Query: 132 SFAIGLT-PMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPL 190 S I + P+ G + + + + +CL D + V F +PL Sbjct: 137 SVGISMPIPVFGLQDDSKVFK-----------EGSCLLAD----DNFVLIGSFVSFFIPL 181 Query: 191 LLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 +M+ Y + +++ +E ++K +AA+ Sbjct: 182 TIMVITYFLTIKSLQKEAADLEDNWETLNDNLKVIEKADNAAQV 225 Score = 82.4 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 26/106 (24%), Positives = 46/106 (43%), Gaps = 4/106 (3%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD 261 AA QLK + + ++ E A K L I+ LF + W P I N C + Sbjct: 267 QAAAEQLKTTINAYIQKYGQ--SISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKE 324 Query: 262 CSHAPL--WLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 + + L+ + + + + +S VNP +Y + +R F + I+ Sbjct: 325 SCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQC 370 >6DRY-A nrPDB Length = 411 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 58/227 (25%), Positives = 99/227 (43%), Gaps = 16/227 (7%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP---FAITIST 68 + L + + I GN LV AV L LQ TNYF++SLA AD+ VG+ +P I Sbjct: 25 LILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEA 84 Query: 69 GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C ++ + +SI+ L AI++DRYIAI+ P++ N + A I + Sbjct: 85 MWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVV 144 Query: 129 WVLSFAIGLT-PMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL 187 W++S I + P+ G + + C+ ++M+ F A Sbjct: 145 WLISIGIAIPVPIKGI-----------ETDVDNPNNITCVLTKERFGDFML-FGSLAAFF 192 Query: 188 VPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 PL +M+ Y A +++ +E ++K +AA+ Sbjct: 193 TPLAIMIVTYFLTIHALQKKAADLEDNWETLNDNLKVIEKADNAAQV 239 Score = 95.2 bits (235), Expect = 5e-20, Method: Composition-based stats. Identities = 29/112 (25%), Positives = 49/112 (43%), Gaps = 2/112 (1%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD 261 AA QLK + + ++ ++ A+K L I+ LF L W P I N C Sbjct: 301 QAAAEQLKTTRNAYIQKYLVQTISNEQ-RASKVLGIVFFLFLLMWCPFFITNITLVLCDS 359 Query: 262 CSHAPL-WLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQE 312 C+ L L+ + + + + +S VNP +Y + FR F + I + + Sbjct: 360 CNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKS 411 >5DSG-A nrPDB Length = 422 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 58/230 (25%), Positives = 104/230 (45%), Gaps = 18/230 (7%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA--ITIST 68 TV +++++ ++GN+LV ++ +N LQ V NYF+ SLA AD+ +G ++ I Sbjct: 18 TVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKG 77 Query: 69 GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C V++ +S+ +LL I+ DRY + PL Y T A +IA Sbjct: 78 YWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAA 137 Query: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 WVLSF + +L W + ++ F + + + A + Sbjct: 138 WVLSFVLWAPAILFWQFVVGKRTVPDNQC----------FIQFLSNPAVTFGTAIAAFYL 187 Query: 189 PLLLMLGVYLRIFLAARRQLKQMESQPLP------GERARSTLQKEVHAA 232 P+++M +Y+ I LA+R ++ E + G+ A ++V AA Sbjct: 188 PVVIMTVLYIHISLASRSRVNIFEMLRIDEGGGSGGDEAEKLFNQDVDAA 237 Score = 95.9 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 45/112 (40%), Gaps = 5/112 (4%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + +E +++ I+ F L W P +++ Sbjct: 302 YNQTPNRAKRVITTFRTGTWDAYQ---MAARERKVTRTIFAILLAFILTWTPYNVMVLVN 358 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVL 308 FC C +W + L + NS +NP YA F++TFR ++ Sbjct: 359 TFCQSCIPDTVWS--IGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR 408 >4BWB-A nrPDB Length = 338 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 71/327 (21%), Positives = 133/327 (40%), Gaps = 33/327 (10%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQN---VTNYFVVSLAAADIAVGVLAIPF 62 + + LA+ V+ +GN + + + +LQ+ +Y++ SLA +D+ + + A+P Sbjct: 19 KVLVTAIYLALFVVGTVGNGVTLFTLARKKSLQSLQSRVDYYLGSLALSDLLILLFALPV 78 Query: 63 ----AITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 I + + GC T ++ ++++++++ Y+AI P + L++ Sbjct: 79 DLYNFIWVHHPWAFGDAGCKGYYFLREACTYATALNVVSLSVELYLAICHPFKAKTLMSR 138 Query: 119 TRAKGIIAICWVLS--FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACL-FEDVVPMN 175 +R K I+ W+ S AI + +G N G G + C D + Sbjct: 139 SRTKKFISAIWLASALLAIPMLFTMGLQNLS--------GDGTHPGGLVCTPIVDTATLR 190 Query: 176 YMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAK-- 233 ++ N F L P+L+ + A R+L M Q R T V A + Sbjct: 191 VVIQLNTFMSFLFPMLV----ASILNTVAARRLTVMVHQAAEQGRV-CTEPGRVQALRRG 245 Query: 234 --SLAIIVGLFALCWLPLHIINC-FTFFCPDCSHAPLWLMY-----LAIVLSHTNSVVNP 285 L +V F +CWLP H+ F + + L+ Y L+ L + ++ +NP Sbjct: 246 VLVLRAVVIAFVVCWLPYHVRRLMFVYISDEQWTTALFDFYHYFYMLSNALVYVSAAINP 305 Query: 286 FIYAYRIREFRQTFRKIIRSHVLRQQE 312 +Y FRQ F + +E Sbjct: 306 ILYNLVSANFRQVFLSTLACLCPGTRE 332 >3PBL-A nrPDB Length = 481 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 64/240 (26%), Positives = 104/240 (43%), Gaps = 27/240 (11%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT 65 + Y A+ + + GN LVC AV LQ TNY VVSLA AD+ V L +P+ + Sbjct: 38 HAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVY 97 Query: 66 ISTG---FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYN---GLVTGT 119 + + + C +++ +SI++L AI+IDRY A+ +P+ Y G + Sbjct: 98 LEVTGGVWNFSRICCDVFVTLDVMMCTASIWNLCAISIDRYTAVVMPVHYQHGTGQSSCR 157 Query: 120 RAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY 179 R +I WVL+FA+ + G+N G P C + V Sbjct: 158 RVALMITAVWVLAFAVSCPLLFGFNTTGDP--------------TVCSISNP----DFVI 199 Query: 180 FNFFACVLVPLLLMLGVYLRIF--LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 ++ +P + + VY RI+ L RR+ E + E R + K+ ++ I Sbjct: 200 YSSVVSFYLPFGVTVLVYARIYVVLKQRRRKNIFEMLRI-DEGLRLKIYKDTEGYYTIGI 258 Score = 99.0 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 30/109 (27%), Positives = 47/109 (43%), Gaps = 4/109 (3%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + +E A + +AI++G F +CWLP + + Sbjct: 368 YNQTPNRAKRVITTFRTGTWDAYGVPL---REKKATQMVAIVLGAFIVCWLPFFLTHVLN 424 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 C C +P L L + NS +NP IY EFR+ F KI+ Sbjct: 425 THCQTCHVSPE-LYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 472 >4EJ4-A nrPDB Length = 461 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 50/237 (21%), Positives = 91/237 (38%), Gaps = 12/237 (5%) Query: 3 IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF 62 + + + A+ + +LGNVLV + + + L+ TN ++ +LA AD A+ +PF Sbjct: 11 LALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALAD-ALATSTLPF 69 Query: 63 AI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR 120 + + C + +SIF+L +++DRYIA+ P++ T + Sbjct: 70 QSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAK 129 Query: 121 AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180 AK I WVL+ +G+ M+ G + Sbjct: 130 AKLINICIWVLASGVGVPIMVM--------AVTQPRDGAVVCMLQFPSPSWYWDTVTKIC 181 Query: 181 NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 F +VP+L++ Y + L R E + E R + K ++ I Sbjct: 182 VFLFAFVVPILIITVCYGLMLLRLRSVRNIFEMLRI-DEGLRLKIYKNTEGYYTIGI 237 Score = 91.7 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 5/117 (4%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + +L+ + + ++VG F +CW P+HI Sbjct: 347 YNQTPNRAKRVITTFRTGTWDAYEKDRSLR---RITRMVLVVVGAFVVCWAPIHIFVIVW 403 Query: 257 FFCPDCSHAPLWL--MYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQ 311 PL + ++L I L + NS +NP +YA+ F++ FR++ R+ RQ+ Sbjct: 404 TLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQE 460 >6CM4-A nrPDB Length = 430 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 66/233 (28%), Positives = 109/233 (46%), Gaps = 23/233 (9%) Query: 9 YITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS- 67 Y T+ + + + GNVLVC AV LQ TNY +VSLA AD+ V L +P+ + + Sbjct: 3 YATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV 62 Query: 68 -TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLV-TGTRAKGII 125 + + C +++ +S +L AI+IDRY A+ +P+ YN + R +I Sbjct: 63 VGEWKFSRIHCDIFVTLDVMMCTASALNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMI 122 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 +I WVLSF I + G NN Q + C+ + + Y + Sbjct: 123 SIVWVLSFTISCPLLFGLNNADQNE---------------CIIANPAFVVY----SSIVS 163 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLP-GERARSTLQKEVHAAKSLAI 237 VP ++ L VY++I++ RR+ K+ + L E R + K+ ++ I Sbjct: 164 FYVPFIVTLLVYIKIYIVLRRRRKRNIFEMLRIDEGLRLKIYKDTEGYYTIGI 216 Score = 97.5 bits (241), Expect = 9e-21, Method: Composition-based stats. Identities = 33/109 (30%), Positives = 48/109 (44%), Gaps = 4/109 (3%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + + QKE A + AI+ G+F +CWLP I + Sbjct: 326 YNQTPNRAKRVITTFRTGTWDAY--KLSQQKEKKATQMAAIVAGVFIICWLPFFITHILN 383 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 C + P L L + NS VNP IY EFR+ F KI+ Sbjct: 384 IHCD--CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 430 >4DJH-A nrPDB Length = 480 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 51/246 (20%), Positives = 105/246 (42%), Gaps = 23/246 (9%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 +P++ ++VY V V+ ++GN LV + + + ++ TN ++ +LA AD V + Sbjct: 21 IPVIITAVYSVV----FVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TM 75 Query: 61 PF--AITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 PF + + + C + +SIF+L +++DRYIA+ P++ T Sbjct: 76 PFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP 135 Query: 119 TRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVV---PMN 175 +AK I W+LS ++G++ ++ G + + + F D Sbjct: 136 LKAKIINICIWLLSSSVGISAIV--------LGGTKVREDVDVIECSLQFPDDDYSWWDL 187 Query: 176 YMVYFNFFACVLVPLLLMLGVYLRIFLAARRQL----KQMESQPLPGERARSTLQKEVHA 231 +M F ++P+L+++ Y + L + E + E R + K+ Sbjct: 188 FMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGNIFEMLRI-DEGLRLKIYKDTEG 246 Query: 232 AKSLAI 237 ++ I Sbjct: 247 YYTIGI 252 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 3/108 (2%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + R + + + + + ++V +F +CW P+HI Sbjct: 362 YNQTPNRAKRVITTFRTGTWDAYREKDRNLRRI--TRLVLVVVAVFVVCWTPIHIFILVE 419 Query: 257 FFC-PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 S A L Y I L +TNS +NP +YA+ F++ FR Sbjct: 420 ALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFC 467 >5CXV-A nrPDB Length = 515 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 50/225 (22%), Positives = 95/225 (42%), Gaps = 14/225 (6%) Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCA 72 +++ + GN+LV + +N+ L+ V NYF++SLA AD+ +G ++ T + + Sbjct: 59 LLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWAL 118 Query: 73 ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132 C V +Q+S+ +LL I+ DRY ++ PL Y T RA +I + W++S Sbjct: 119 GTLACDLWLALDYVASQASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVS 178 Query: 133 FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLL 192 F + +L W + + + + A +P+ + Sbjct: 179 FVLWAPAILFWQYLVGERTVLAGQCYI----------QFLSQPIITFGTAMAAFYLPVTV 228 Query: 193 MLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 M +Y RI+ + E + E R + K+ ++ I Sbjct: 229 MCTLYWRIYRETENR-NIFEMLRI-DEGLRLKIYKDTEGYYTIGI 271 Score = 99.4 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 34/115 (29%), Positives = 54/115 (46%), Gaps = 5/115 (4%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + L KE AA++L+ I+ F L W P +I+ + Sbjct: 381 YNQTPNRAKRVITTFRTGTWDAYFS---LVKEKKAARTLSAILLAFILTWTPYNIMVLVS 437 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQ 311 FC DC LW L L + NS +NP YA + FR TFR ++ +++ Sbjct: 438 TFCKDCVPETLW--ELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRR 490 >5WS3-A nrPDB Length = 560 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 65/222 (29%), Positives = 98/222 (44%), Gaps = 10/222 (4%) Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAIT 65 V I + + V+A++GNVLVC AVW N +++ VTNYF+V+L+ AD+ V + +P + Sbjct: 63 VLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVD 122 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 I+ + C I V S+ +L IA+DR+ AI PL + T RA+ I Sbjct: 123 ITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARNSI 180 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 I W++S I + P C G + ++ P Y + F F Sbjct: 181 VIIWIVSCII-MIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICF-FLVT 238 Query: 186 VLVPLLLMLGVYLRIFLAA----RRQLKQMESQPLPGERARS 223 + PL LM+ YL+IF L G R Sbjct: 239 YMAPLCLMVLAYLQIFRKLWCRQGIDCSFWNESYLTGSRDER 280 Score = 82.1 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 21/91 (23%), Positives = 39/91 (42%), Gaps = 5/91 (5%) Query: 223 STLQKEVHAAKSLAIIVGLFALCWLPLHIINCF-----TFFCPDCSHAPLWLMYLAIVLS 277 ++ A+ L +++ +FA+C+LP+ I+N F + + L Sbjct: 458 KQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLV 517 Query: 278 HTNSVVNPFIYAYRIREFRQTFRKIIRSHVL 308 + NS NP IY + +FR+ F+ L Sbjct: 518 YANSAANPIIYNFLSGKFREEFKAAFSCCCL 548 >4BUO-A nrPDB Length = 335 Score = 170 bits (431), Expect = 9e-43, Method: Composition-based stats. Identities = 65/325 (20%), Positives = 126/325 (38%), Gaps = 31/325 (9%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQN---VTNYFVVSLAAADIAVGVLAIPF 62 + + LA+ V+ +GN + + + +LQ+ +Y++ SLA +D+ + +LA+P Sbjct: 18 KVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVDYYLGSLALSDLLILLLAMPV 77 Query: 63 AIT----ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 + + + GC T ++ ++++++++ Y+AI P + L++ Sbjct: 78 ELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSR 137 Query: 119 TRAKGIIAICWVLS--FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACL-FEDVVPMN 175 +R K I+ W+ S AI + +G N G G + C D + Sbjct: 138 SRTKKFISAIWLASALLAIPMLFTMGLQNLS--------GDGTHPGGLVCTPIVDTATLK 189 Query: 176 YMVYFNFFACVLVPLLL--MLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAK 233 ++ N F L P+L+ +L + L PG +Q Sbjct: 190 VVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQAAFNMTIEPG-----RVQALRRGVL 244 Query: 234 SLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPL------WLMYLAIVLSHTNSVVNPFI 287 L +V F +CWLP H+ + D + L L + ++ +NP + Sbjct: 245 VLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPIL 304 Query: 288 YAYRIREFRQTFRKIIRSHVLRQQE 312 Y FRQ F + +E Sbjct: 305 YNLVSANFRQVFLSTLACLCPGTRE 329 >6BQH-A nrPDB Length = 452 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 58/212 (27%), Positives = 91/212 (42%), Gaps = 16/212 (7%) Query: 26 LVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF---AITISTGFCAACHGCLFIAC 82 LV AV + L N TNYF++SLA AD+ VG+L +P AI + + C Sbjct: 60 LVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWIS 119 Query: 83 FVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLG 142 ++ + +SI L AI++DRY+AIR P+ ++ + T+A IAI W +S + + Sbjct: 120 LDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVP---- 175 Query: 143 WNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFL 202 P G + C+ D V F +PL +M+ Y Sbjct: 176 -----IPVIGLRDEEKVFVNNTTCVLNDPN----FVLIGSFVAFFIPLTIMVITYCLTIY 226 Query: 203 AARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 RRQ +E ++K +AA+ Sbjct: 227 VLRRQAADLEDNWETLNDNLKVIEKADNAAQV 258 Score = 90.9 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 27/114 (23%), Positives = 51/114 (44%), Gaps = 4/114 (3%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD 261 AA QLK + + + E A+K L I+ +F + W P I N + C Sbjct: 320 QAAAEQLKTTRNAYIQKYLQA--INNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEK 377 Query: 262 CSHAPLW--LMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEP 313 + L L+ + + + + NS +NP +Y + +R+ F +R + +++P Sbjct: 378 SCNQKLMEKLLNVFVWIGYVNSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKP 431 >5ZBH-A nrPDB Length = 527 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 52/243 (21%), Positives = 103/243 (42%), Gaps = 14/243 (5%) Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60 +P+ A+ +L + GN+ + + ++NVTN +V+L+ +D+ V ++ + Sbjct: 44 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL 103 Query: 61 PFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 PF T+ + C V SI+SL+ IA++R+ I P G Sbjct: 104 PFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIWSLVLIAVERHQLIINP---RGWRPN 160 Query: 119 TRAKGI-IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYM 177 R + IA+ WVL+ A L ++ +P +N + + + C F+ ++ Sbjct: 161 NRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPF--QNVTLDAYKDKYVC-FDQFPSDSHR 217 Query: 178 VYFNFFACVLV---PLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 + + VL PL + Y +I++ +R+ E + E R + K+ + Sbjct: 218 LSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR-NIFEMLRI-DEGLRLKIYKDTEGYYT 275 Query: 235 LAI 237 + I Sbjct: 276 IGI 278 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 26/120 (21%), Positives = 46/120 (38%), Gaps = 6/120 (5%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCF- 255 Y + A+R + + + + L IV FA+CWLPL I N Sbjct: 388 YNQTPNRAKRVITTFRTGTWDAYDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVF 447 Query: 256 ---TFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQE 312 C+H L+L L + + ++ VNP Y + + F++ + R ++ Sbjct: 448 DWNHQIIATCNHNLLFL--LCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRD 505 >6DO1-A nrPDB Length = 425 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 51/227 (22%), Positives = 90/227 (39%), Gaps = 11/227 (4%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--- 67 T+ I V+ I GN LV ++ L+ V + F+++LA AD+ +L +P + Sbjct: 40 TLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCF-LLTLPLWAVYTAME 98 Query: 68 TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAI 127 + + C + V +S+F L ++IDRY+AI P++ T AK I Sbjct: 99 YRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCII 158 Query: 128 CWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL 187 W+L+ L ++ N E Q + L + L Sbjct: 159 IWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTL------PIGLGLTKNILGFL 212 Query: 188 VPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 P L++L Y I+ A ++ +E ++K +AA+ Sbjct: 213 FPFLIILTSYTLIWKALKKAY-DLEDNWETLNDNLKVIEKADNAAQV 258 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 45/110 (40%), Gaps = 12/110 (10%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP- 260 AA QLK + + + R K + IV F W+P I Sbjct: 320 QAAAEQLKTTRNAEIQKNKPR-----NDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQL 374 Query: 261 ----DCSHAPLW--LMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 DC A + M + I +++ N+ +NP Y + ++F++ F ++++ Sbjct: 375 GIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLK 424 >4ZJC-A nrPDB Length = 553 Score = 154 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 60/207 (28%), Positives = 85/207 (41%), Gaps = 10/207 (4%) Query: 23 GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAITISTGFCAACHGCLFI 80 GN LVC AVW N +++ VTNYF+V+L+ AD+ V + +P + I+ + C I Sbjct: 71 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVI 130 Query: 81 ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPM 140 V ++ +L IA+DR+ AI PL + T RA+G I W +S AI + P Sbjct: 131 PYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVPQ 187 Query: 141 LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRI 200 C + +D+ P Y F F L PL LM Y +I Sbjct: 188 AAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCF-FIVTYLAPLGLMAMAYFQI 246 Query: 201 FLAA----RRQLKQMESQPLPGERARS 223 F L G R Sbjct: 247 FRKLWGRQGIDCSFWNESYLTGSRDER 273 Score = 77.8 bits (190), Expect = 7e-15, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 38/89 (42%), Gaps = 5/89 (5%) Query: 223 STLQKEVHAAKSLAIIVGLFALCWLPLHIINCF-----TFFCPDCSHAPLWLMYLAIVLS 277 ++ AK L +++ +FALC+LP+ ++N F A + L Sbjct: 451 KQMRARRKTAKMLMVVLLVFALCYLPISVLNILKRVFGMFRQASDREAVYACFTFSHWLV 510 Query: 278 HTNSVVNPFIYAYRIREFRQTFRKIIRSH 306 + NS NP IY + +FR+ F+ Sbjct: 511 YANSAANPIIYNFLSGKFREQFKAAFSCC 539 >5U09-A nrPDB Length = 508 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 58/221 (26%), Positives = 87/221 (39%), Gaps = 19/221 (8%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNY-FVVSLAAADIAVGVLAIPFAI 64 + L + +L N+LV + + +L+ +Y F+ SLA AD+ V+ + I Sbjct: 28 QLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFI 87 Query: 65 TISTGFCAACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 LF V +S+ SL AIDRYI+I PL Y +VT +A Sbjct: 88 DFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLAAIDRYISIHRPLAYKRIVTRPKAVV 147 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183 + W ++ I + P+LGWN C + Q C D+ P Y F+ Sbjct: 148 AFCLMWTIAIVIAVLPLLGWN--------------CEKLQSVC--SDIFPHIDETYLMFW 191 Query: 184 ACVL-VPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARS 223 V V LL ++ Y+ I A L G R Sbjct: 192 IGVTSVLLLFIVYAYMYILWKAGIDCSFWNESYLTGSRDER 232 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 25/89 (28%), Positives = 39/89 (43%), Gaps = 1/89 (1%) Query: 223 STLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSV 282 + ++ AK+L +I+ + +CW PL I + F + +L NS Sbjct: 410 DQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAF-CSMLCLLNST 468 Query: 283 VNPFIYAYRIREFRQTFRKIIRSHVLRQQ 311 VNP IYA R ++ R FR + S Q Sbjct: 469 VNPIIYALRSKDLRHAFRSMFPSCEGTAQ 497 >5UNF-A nrPDB Length = 411 Score = 151 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 110/304 (36%), Gaps = 28/304 (9%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG- 69 + I V+ L N++V + V++ ++ +LA AD+ + +A S Sbjct: 125 ILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRY 184 Query: 70 -FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C F+ + +SIF + +++DRY ++ P +A I+ + Sbjct: 185 DWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQ-RRNPWQASYIVPLV 243 Query: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 W ++ L + G N + + + ++ Sbjct: 244 WCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPE-----KYAQWSAGIALMKNILGFII 298 Query: 189 PLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLP 248 PL+ + Y I R+ L + S K A +V F +CWLP Sbjct: 299 PLIFIATCYFGI----RKHLLKTNSYG-------KNRITRDQVLKMAAAVVLAFIICWLP 347 Query: 249 LHIINCFTFF--------CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300 H++ C + L L + AI+L TNS VNPF+Y + F+Q R Sbjct: 348 FHVLTFLDALAWMGVINSCEVIAVIDLALPF-AILLGFTNSCVNPFLYCFVGNRFQQKLR 406 Query: 301 KIIR 304 + R Sbjct: 407 SVFR 410 >6GPS-A nrPDB Length = 429 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 58/355 (16%), Positives = 118/355 (33%), Gaps = 58/355 (16%) Query: 4 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63 +G+ + + + + +GN+LV + L+ +T+ ++++LA +D+ + +A Sbjct: 39 IGAQLLPPLYSLVFIFGFVGNMLVVLILINYKKLKCLTDIYLLNLAISDLLFLITLPLWA 98 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 + + + C + IF ++ + IDRY+AI + T T Sbjct: 99 HSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVV 158 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVV-PMNYMVYFNF 182 I W+++ + ++ + C N+ Sbjct: 159 TSVITWLVAVFASVPNIIF------------TKCQKEDSVYVCGPYFPRGWNNFHTIMRN 206 Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQM---------------ESQPLPGERARST--- 224 +++PLL+M+ Y I R K ++ PG + Sbjct: 207 ILGLVLPLLIMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDD 266 Query: 225 ------------------LQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF-------- 258 +K + + I+ ++ L W P +I+ F Sbjct: 267 WVCPLCGVGKDQFEEVEEEKKRHRDVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSN 326 Query: 259 CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEP 313 C S + L T+ +NP IYA+ EFR F + + Q+P Sbjct: 327 CESTSQLD-QATQVTETLGMTHCCINPIIYAFVGEEFRSLFHIALGCRIAPLQKP 380 >6J20-A nrPDB Length = 441 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 47/217 (21%), Positives = 86/217 (39%), Gaps = 26/217 (11%) Query: 28 CWAVWLNSNLQNVTNYFVVSLAAADIAVGVL--AIPFAITISTGFCAACHGCLFIACFVL 85 W + + ++ VTNYF+V+LA A+ ++ + F + + C F F + Sbjct: 53 MWIILAHKRMRTVTNYFLVNLAFANASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPI 112 Query: 86 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNN 145 +SI+S+ A+A DRY+AI PL+ ++ T K +I + WVL+ + Sbjct: 113 AAVFASIWSMTAVAFDRYMAIIHPLQ--PRLSATATKVVICVIWVLALLLAFP------- 163 Query: 146 CGQPKEGKNHSQGCGEGQVACLFEDV-----VPMNYMVYFNFFACVLVPLLLMLGVYLRI 200 +G + +V C+ E + +PLL++ Y + Sbjct: 164 -----QGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVV 218 Query: 201 FLAA-----RRQLKQMESQPLPGERARSTLQKEVHAA 232 + L+ E G+ A ++V AA Sbjct: 219 GIRLWASNIFEMLRIDEGGGSGGDEAEKLFNQDVDAA 255 Score = 77.8 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 31/125 (24%), Positives = 53/125 (42%), Gaps = 10/125 (8%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + + +++V + + FA+CWLP HI Sbjct: 320 YNQTPNRAKRVITTFRTGTWDAYHEQVSAKRKVVKMMIVVV--CTFAICWLPFHIFFLLP 377 Query: 257 FFCPDCSHAP-LWLMYLAI-VLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPF 314 + PD + +YLAI L+ ++++ NP IY FR F+ R PF Sbjct: 378 YINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCC------PF 431 Query: 315 KAAGT 319 +AG Sbjct: 432 ISAGD 436 >5XRA-A nrPDB Length = 438 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 55/206 (26%), Positives = 85/206 (41%), Gaps = 19/206 (9%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNY-FVVSLAAADIAVGVLAIPFAI 64 + L + +L N+LV + + +L+ +Y F+ SLA AD+ V+ + I Sbjct: 18 QLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFI 77 Query: 65 TISTGFCAACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 LF V +S+ SL AIDRYI+I PL Y +VT +A Sbjct: 78 DFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLAAIDRYISIHRPLAYKRIVTRPKAVV 137 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183 + W ++ I + P+LGWN C + Q C D+ P Y F+ Sbjct: 138 AFCLMWTIAIVIAVLPLLGWN--------------CEKLQSVC--SDIFPHIDKTYLMFW 181 Query: 184 ACVL-VPLLLMLGVYLRIFLAARRQL 208 V+ V LL ++ Y+ I A Sbjct: 182 IGVVSVLLLFIVYAYMYILWKAHSHA 207 Score = 68.6 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 24/83 (28%), Positives = 38/83 (45%), Gaps = 1/83 (1%) Query: 223 STLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSV 282 + ++ AK+L +I+ + +CW PL I + F + +L NS Sbjct: 357 DQARMDIELAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAF-CSMLCLLNST 415 Query: 283 VNPFIYAYRIREFRQTFRKIIRS 305 VNP IYA R ++ R FR + S Sbjct: 416 VNPIIYALRSKDLRHAFRSMFPS 438 >5XSZ-A nrPDB Length = 477 Score = 144 bits (362), Expect = 9e-35, Method: Composition-based stats. Identities = 51/234 (21%), Positives = 92/234 (39%), Gaps = 11/234 (4%) Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AIT 65 +Y V + ++ ++ NV + + L+N T ++++L +D+ VL +P Sbjct: 30 LYSMVFSIVFMVGLITNVAAMYIFMCSLKLRNETTTYMMNLVVSDLLF-VLTLPLRVFYF 88 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 + + C SI L I++DR++AI P R GL T AK + Sbjct: 89 VQQNWPFGSLLCKLSVSLFYTNMYGSILFLTCISVDRFLAIVYPFRSRGLRTKRNAKIVC 148 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 A WVL + L N+ + + N+S C E + E ++ +V F Sbjct: 149 AAVWVLVLSGSLPTGFMLNSTNKLE---NNSISCFENFSS--KEWKSHLSKVVIFIETVG 203 Query: 186 VLVPLLLMLGVYLRIFLAARR--QLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 L+PL+L + + RR + E + R + K ++ I Sbjct: 204 FLIPLMLNVVCSAMVLQTLRRPNTVNIFEMLRI-DNGLRLKIYKNTEGYYTIGI 256 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 11/108 (10%), Positives = 36/108 (33%), Gaps = 13/108 (12%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + + + + + +F C++P ++ F Sbjct: 366 YNQTPNRAKRVITTFRTGTWDAYLNKK------KILRMIIVHLFIFCFCFIPYNVNLVFY 419 Query: 257 FFCPDCSHA-------PLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 297 + + +A+ ++ +N +P +Y + + Sbjct: 420 SLVRTNTLKGCAAESVVRTIYPIALCIAVSNCCFDPIVYYFTSETIQN 467 >2LNL-A nrPDB Length = 309 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 118/311 (37%), Gaps = 36/311 (11%) Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS 67 V I + +L++LGN LV + + ++VT+ ++++LA AD+ + +A + Sbjct: 22 VVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV 81 Query: 68 TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA--KGII 125 G+ C ++ V S I L I++DRY+AI +T R K + Sbjct: 82 NGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVH---ATRTLTQKRHLVKFVC 138 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 CW LS + L L Q N S C E + + Sbjct: 139 LGCWGLSMNLSLPFFLF----RQAYHPNNSSPVCYE---VLGNDTAKWRMVLRILPHTFG 191 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 245 +VPL +ML Y ++ + ++ A + + +V +F LC Sbjct: 192 FIVPLFVMLFCYGFTLRTL----------------FKAHMGQKHRAMRVIFAVVLIFLLC 235 Query: 246 WLPLHIINCFTFFCPDCSHAPL--------WLMYLAIVLSHTNSVVNPFIYAYRIREFRQ 297 WLP +++ + +L +S +NP IYA+ + FR Sbjct: 236 WLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRH 295 Query: 298 TFRKIIRSHVL 308 F KI+ H L Sbjct: 296 GFLKILAMHGL 306 >3V2Y-A nrPDB Length = 520 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 60/233 (25%), Positives = 98/233 (42%), Gaps = 21/233 (9%) Query: 7 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGV-LAIPFAIT 65 + V + I IL N+ V +W YF+ +LA +D+ GV ++ Sbjct: 64 KLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLS 123 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 +T + + V +S+FSLLAIAI+RYI + +NG R +I Sbjct: 124 GATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNG-SNNFRLFLLI 182 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 + CWV+S +G P++GWN C +C V+P+ + Y F Sbjct: 183 SACWVISLILGGLPIMGWN--------------CISALSSC--STVLPLYHKHYILFCTT 226 Query: 186 VLVPLLL-MLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 V LLL ++ +Y RI+ R + E + E R + K+ ++ I Sbjct: 227 VFTLLLLSIVILYCRIYSLVRTR-NIFEMLRI-DEGLRLKIYKDTEGYYTIGI 277 Score = 87.8 bits (216), Expect = 7e-18, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 48/107 (44%), Gaps = 2/107 (1%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + +RS+ V K++ I++ +F CW PL I+ Sbjct: 387 YNQTPNRAKRVITTFRTGTWDAYASRSSEN--VALLKTVIIVLSVFIACWAPLFILLLLD 444 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 C + L+ +VL+ NS NP IY +E R+ F +I+ Sbjct: 445 VGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIM 491 >5GLH-A nrPDB Length = 498 Score = 141 bits (355), Expect = 6e-34, Method: Composition-based stats. Identities = 45/229 (19%), Positives = 86/229 (37%), Gaps = 5/229 (2%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--IST 68 V + VL I+GN + + ++ N ++N N + SLA D+ V+AIP + ++ Sbjct: 44 VVSCLVFVLGIIGNSTLLYIIYKNKCMRNGPNILIASLALGDLLHIVIAIPINVYKLLAE 103 Query: 69 GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C + ++ SL A++IDRY A+ R G+ I + Sbjct: 104 DWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLI 163 Query: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 WV+S + + +G++ +G F ++ F + Sbjct: 164 WVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYATA-KDWWLFSFYFCL 222 Query: 189 PLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 PL + Y + R+ E + E R + K+ ++ I Sbjct: 223 PLAITAFFYTLMTCEMLRK-NIFEMLRI-DEGLRLKIYKDTEGYYTIGI 269 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 9/117 (7%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHI----- 251 Y + A+R + + L++ AK++ +V +FALCWLPLH+ Sbjct: 379 YNQTPNRAKRVITTFRTGTWDAYLN-DHLKQRREVAKTVFCLVLVFALCWLPLHLARILK 437 Query: 252 INCFTFFCPDCSHAPLWLM---YLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 + + P+ +L+ Y+ I ++ NS NP + F+ F+ + Sbjct: 438 LTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCANPIALYLVSKRFKNAFKSALCC 494 >5UIW-A nrPDB Length = 411 Score = 140 bits (354), Expect = 7e-34, Method: Composition-based stats. Identities = 68/372 (18%), Positives = 130/372 (34%), Gaps = 63/372 (16%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFC 71 + + + +GN+LV + L+++T+ ++++LA +D+ + +A + + Sbjct: 38 LYSLVFIFGFVGNMLVILILINYKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWD 97 Query: 72 AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVL 131 C + + S IF ++ + IDRY+A+ + T T I WV+ Sbjct: 98 FGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVV 157 Query: 132 SFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLL 191 + L ++ KEG +++ F N+ +++PLL Sbjct: 158 AVFASLPNIIF---TRSQKEGLHYTCSSHFPYSQYQF----WKNFQTLKIVILGLVLPLL 210 Query: 192 LMLGVYLRIFLAARRQLKQM---------------ESQPLPGERARST------------ 224 +M+ Y I R K ++ PG + Sbjct: 211 VMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPLCGVG 270 Query: 225 ---------LQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP-------DCSHAPLW 268 +K + + I+ ++ L W P +I+ F S+ Sbjct: 271 KDQFEEVEEEKKRHRDVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQ 330 Query: 269 LMYLAIVLSHTNSVVNPFIYAYRIREFRQTF-----RKIIRSHV--LRQQEPFKAAGTSA 321 M + L T+ +NP IYA+ EFR + I +Q+ P +A+ Sbjct: 331 AMQVTETLGMTHCCINPIIYAFVGEEFRNYLLVFFQKHIFCKCCSIFQQEAPERASSVYT 390 Query: 322 RVLAAHGSDGEQ 333 R S GEQ Sbjct: 391 R------STGEQ 396 >6AKX-A nrPDB Length = 381 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 61/347 (17%), Positives = 123/347 (35%), Gaps = 50/347 (14%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFC 71 + + + +GN+LV + L+++T+ ++++LA +D+ + +A + + Sbjct: 38 LYSLVFIFGFVGNMLVILILINYKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWD 97 Query: 72 AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVL 131 C + + S IF ++ + IDRY+A+ + T T I WV+ Sbjct: 98 FGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVV 157 Query: 132 SFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLL 191 + L ++ KEG +++ F N+ +++PLL Sbjct: 158 AVFASLPNIIF---TRSQKEGLHYTCSSHFPYSQYQF----WKNFQTLKIVILGLVLPLL 210 Query: 192 LMLGVYLRIFLAARRQLKQM---------------ESQPLPGERARST------------ 224 +M+ Y I R K ++ PG + Sbjct: 211 VMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPLCGVG 270 Query: 225 ---------LQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP-------DCSHAPLW 268 +K + + I+ ++ L W P +I+ F S+ Sbjct: 271 KDQFEEVEEEKKRHRDVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQ 330 Query: 269 LMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFK 315 M + L T+ +NP IYA+ EFR + H+ ++ P + Sbjct: 331 AMQVTETLGMTHCCINPIIYAFVGEEFRNYLLVFFQKHIAKRGRPLE 377 >5GLI-A nrPDB Length = 464 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 47/229 (20%), Positives = 86/229 (37%), Gaps = 8/229 (3%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--IST 68 V + VL I+GN + + ++ N ++N N + SLA D+ V+AIP + ++ Sbjct: 44 VVSCLVFVLGIIGNSTLLYIIYKNKCMRNGPNILIASLALGDLLHIVIAIPINVYKLLAE 103 Query: 69 GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C + ++ SL A++IDRY A+ R G+ I + Sbjct: 104 DWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLI 163 Query: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 WV+S + + +G++ +G F ++ F + Sbjct: 164 WVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYATA-KDWWLFSFYFCL 222 Query: 189 PLLLMLGVYLRIFLAARR-----QLKQMESQPLPGERARSTLQKEVHAA 232 PL + Y + R L+ E G+ A ++V AA Sbjct: 223 PLAITAFFYTLMTCEMLRKNIFEMLRIDEGGGSGGDEAEKLFNQDVDAA 271 Score = 62.0 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 9/117 (7%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHI----- 251 Y + A+R + + L++ AK++ +V +FALCWLPLH+ Sbjct: 336 YNQTPNRAKRVITTFRTGTWDAYLN-DHLKQRREVAKTVFCLVLVFALCWLPLHLARILK 394 Query: 252 INCFTFFCPDCSHAPLWLM---YLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 + + P+ +L+ Y+ I ++ NS NP + F+ F+ + Sbjct: 395 LTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCANPIALYLVSKRFKNAFKSALCC 451 >6GPX-A nrPDB Length = 349 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 55/345 (15%), Positives = 114/345 (33%), Gaps = 58/345 (16%) Query: 4 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63 +G+ + + + + +GN+LV + L+ +T+ ++++LA +D+ + +A Sbjct: 12 IGAQLLPPLYSLVFIFGFVGNMLVVLILINYKKLKCLTDIYLLNLAISDLLFLITLPLWA 71 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 + + + C + IF ++ + IDRY+AI + T T Sbjct: 72 HSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVV 131 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVV-PMNYMVYFNF 182 I W+++ + ++ + C N+ Sbjct: 132 TSVITWLVAVFASVPNIIF------------TKCQKEDSVYVCGPYFPRGWNNFHTIMRN 179 Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQM---------------ESQPLPGERARST--- 224 +++PLL+M+ Y I R K ++ PG + Sbjct: 180 ILGLVLPLLIMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDD 239 Query: 225 ------------------LQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF-------- 258 +K + + I+ ++ L W P +I+ F Sbjct: 240 WVCPLCGVGKDQFEEVEEEKKRHRDVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSN 299 Query: 259 CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 C S + L T+ +NP IYA+ +FR F + Sbjct: 300 CESTSQLD-QATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIAL 343 >5WIV-A nrPDB Length = 422 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 68/234 (29%), Positives = 107/234 (45%), Gaps = 25/234 (10%) Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP---FAI 64 + V L AVLA GN LVC +V LQ TN F+VSLAAAD+ + +L +P ++ Sbjct: 42 LVGGVLLIGAVLA--GNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSE 99 Query: 65 TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 124 + + C + ++L +SIF+L AI++DR++A+ +PLRYN R + Sbjct: 100 VQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLL 159 Query: 125 IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 I W+LS A+ + G N+ G C ED +Y+VY + Sbjct: 160 IGATWLLSAAVAAPVLCGLNDVR------------GRDPAVCRLED---RDYVVYSSVC- 203 Query: 185 CVLVPLLLMLGVYLRIFLAARR----QLKQMESQPLPGERARSTLQKEVHAAKS 234 +P LML +Y F +R + +E ++K +AA+ Sbjct: 204 SFFLPCPLMLLLYWATFRGLQRWEVARRADLEDNWETLNDNLKVIEKADNAAQV 257 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 37/106 (34%), Positives = 52/106 (49%), Gaps = 2/106 (1%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD 261 AA QLK + + A+ T +E A + L ++VG F LCW P +++ CP Sbjct: 319 QAAAEQLKTTRNAYIQKYLAKIT-GRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPA 377 Query: 262 CSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHV 307 CS P L+ L + NS +NP IY EFR FRK +R+ Sbjct: 378 CSVPPR-LVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC 422 >6MET-B nrPDB Length = 313 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 112/295 (37%), Gaps = 29/295 (9%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFC 71 + + + +GN+LV + L+++T+ ++++LA +D+ + +A + + Sbjct: 36 LYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWD 95 Query: 72 AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVL 131 C + + S IF ++ + IDRY+A+ + T T I WV+ Sbjct: 96 FGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVV 155 Query: 132 SFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLL 191 + L ++ KEG +++ F N+ +++PLL Sbjct: 156 AVFASLPGIIF---TRSQKEGLHYTCSSHFPYSQYQF----WKNFQTLKIVILGLVLPLL 208 Query: 192 LMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHI 251 +M+ Y I R + +K A + + I+ ++ L W P +I Sbjct: 209 VMVICYSGILKTLLRCRNE---------------KKRHRAVRLIFTIMIVYFLFWAPYNI 253 Query: 252 INCFTFFCP-------DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 299 + F S+ M + L T+ +NP IYA+ +FR Sbjct: 254 VLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYL 308 >4XNV-A nrPDB Length = 421 Score = 134 bits (336), Expect = 9e-32, Method: Composition-based stats. Identities = 66/355 (18%), Positives = 123/355 (34%), Gaps = 60/355 (16%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP---FAITIST 68 V + + ++ LGN + W + + + ++ +LA AD VL +P F T Sbjct: 56 VYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLY-VLTLPALIFYYFNKT 114 Query: 69 GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C V SI L I+ RY + PL+ G + A I + Sbjct: 115 DWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLV 174 Query: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY--FNFFACV 186 W++ + ++P+L ++ G KN + C + D +Y +Y A Sbjct: 175 WLI-VVVAISPILFYSGTG---VRKNKTITCYD-----TTSDEYLRSYFIYSMCTTVAMF 225 Query: 187 LVPLLLMLGVYLRIFLAARRQLKQ------------------------MESQPLPGERA- 221 VPL+L+LG Y I A ++K+ + + +P + Sbjct: 226 CVPLVLILGCYGLIVRALIYKMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVC 285 Query: 222 -----------RSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAP---- 266 + + I++ +FA+ ++P H++ P Sbjct: 286 PLCGVGKDQFEEVEEPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCA 345 Query: 267 -----LWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKA 316 + L+ NS VNP +Y FR+ + R R + ++ Sbjct: 346 FNDRVYATYQVTRGLASLNSCVNPILYFLAGDTFRRRLSRATRKASRRSEANLQS 400 >5LWE-A nrPDB Length = 331 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 52/303 (17%), Positives = 108/303 (35%), Gaps = 33/303 (10%) Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFC 71 + + ++ LGN LV W + + T+ F+++LA AD+ V +AI + + Sbjct: 32 LYWLVFIVGALGNSLVILVYWYCARAKTATDMFLLNLAIADLLFLVTLPFWAIAAADQWK 91 Query: 72 AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGT--RAKGIIAICW 129 C + + S + ++ I +DRYIAI +R + +K + W Sbjct: 92 FQTFMCKVVNSMYKMNFYSCVLLIMCICVDRYIAIAQAMRAHTWREKRLLYSKMVCFTIW 151 Query: 130 VLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189 VL+ A+ + +L + + E + ++ +P Sbjct: 152 VLAAALCIPEILYSQIKEESGIAICTMVYPSD-------ESTKLKSAVLALKVILGFFLP 204 Query: 190 LLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPL 249 ++M Y I + K + A K+ ++ +F L P Sbjct: 205 FVVMACCYTIIIHTLIQAKKSSKH----------------KALKATITVLTVFVLSQFPY 248 Query: 250 HIINCFTF------FCPDCSHAPLWL--MYLAIVLSHTNSVVNPFIYAYRIREFRQTFRK 301 + I F +C+ + + ++ +S +NP +Y + FR+ K Sbjct: 249 NCILLVQTIDAYAMFISNCAVSTAIDICFQVTQAIAFFHSCLNPVLYVFVGERFRRDLVK 308 Query: 302 IIR 304 ++ Sbjct: 309 TLK 311 >6HLP-A nrPDB Length = 520 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 43/206 (20%), Positives = 77/206 (37%), Gaps = 24/206 (11%) Query: 28 CWAVWLNSNLQNVTNYFVVSLAAADIAVGVL--AIPFAITISTGFCAACHGCLFIACFVL 85 W + + ++ VTNYF+V+ A A+ ++ + F + + C F F + Sbjct: 54 MWIILAHKRMRTVTNYFLVNAAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPI 113 Query: 86 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNN 145 +SI+S+ A+A DRY+AI PL+ +T K +I + WVL+ + Sbjct: 114 AAIFASIYSMTAVAFDRYMAIIHPLQPRLSLTA--TKVVICVIWVLALLLAFP------- 164 Query: 146 CGQPKEGKNHSQGCGEGQVACLFEDV-----VPMNYMVYFNFFACVLVPLLLMLGVYLRI 200 +G + +V C E + +PLL++ +Y + Sbjct: 165 -----QGYYSTTETMPSRVVCKIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYLYTVV 219 Query: 201 FLAAR---RQLKQMESQPLPGERARS 223 + R L G R Sbjct: 220 GITLRASGIDCSFWNESYLTGSRDER 245 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 8/81 (9%) Query: 241 LFALCWLPLHIINCFTFFCPDCSHAP-LWLMYLAI-VLSHTNSVVNPFIYAYRIREFRQT 298 FA+CWLP HI + PD + +YLAI L+ ++++ NP IY FR Sbjct: 441 TFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLG 500 Query: 299 FRKIIRSHVLRQQEPFKAAGT 319 F+ R PF +AG Sbjct: 501 FKHAFRCC------PFISAGD 515 >6C1Q-B nrPDB Length = 422 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 57/304 (18%), Positives = 101/304 (33%), Gaps = 31/304 (10%) Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT-- 65 + + + + ++ +LGN LV W + + + + ++LA AD LA+P T Sbjct: 125 LALVIFAVVFLVGVLGNALVVWVTAFEAK-RTINAIWFLNLAVADFL-SCLALPILFTSI 182 Query: 66 -ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 124 + C + +L+ +SI L I+ DR++ + P+ A Sbjct: 183 VQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIA 242 Query: 125 IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 A+ W L+ + + L + K D + Sbjct: 243 CAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDY-------SHDKRRERAVAIVRLVL 295 Query: 185 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL 244 L PLL + Y I L + + K + +V F + Sbjct: 296 GFLWPLLTLTICYTFILLRTWSRRA----------------TRSTKTLKVVVAVVASFFI 339 Query: 245 CWLPLHIINCFTFFCPDCSHAPLWLM---YLAIVLSHTNSVVNPFIYAYRIREFRQTFRK 301 WLP + F S L L L + ++ N +NP IY + F+ RK Sbjct: 340 FWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRK 399 Query: 302 IIRS 305 + S Sbjct: 400 SLPS 403 >5ZTY-A nrPDB Length = 500 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 53/236 (22%), Positives = 94/236 (39%), Gaps = 22/236 (9%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNY-FVVSLAAADIAVGVLAIPFAI 64 + + + +L+ L NV V + + + L+ +Y F+ SLA AD V+ + Sbjct: 32 KTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLALADFLASVVFACSFV 91 Query: 65 TISTGFCAACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 L V + +S+ SLL AIDRY+ +R P Y L+T RA Sbjct: 92 NFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLAAIDRYLCLRYPPSYKALLTRGRALV 151 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183 ++ I WVLS + P++GW C +P ++P +Y++ + F Sbjct: 152 LLGIMWVLSALVSYLPLMGWTCCPRP---------------CSELFPLIPNDYLLSWLLF 196 Query: 184 ACVLVPLLLMLGVYLRIFLAARRQL--KQMESQPLPGERARSTLQKEVHAAKSLAI 237 L ++ Y + A + + E + E R + K+ ++ I Sbjct: 197 IAFLFS--GIIYTYGHVLWKAHQHVASNIFEMLRI-DEGLRLKIYKDTEGYYTIGI 249 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 44/107 (41%), Gaps = 4/107 (3%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + ++ +V AK+L +++ + +CW P+ + + Sbjct: 359 YNQTPNRAKRVITTFRTGTWDAY---ARMRLDVELAKTLGLVLAVLLICWFPVLALMAHS 415 Query: 257 FFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 + +L NS+VNP IYA R E R + + Sbjct: 416 LATTLSDQVKKAFAF-CSMLCLINSMVNPVIYALRSEEIRSSAHHCL 461 >5WB1-A nrPDB Length = 458 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 51/307 (16%), Positives = 104/307 (33%), Gaps = 42/307 (13%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI- 64 V + + + + +GN LV + + +Q + + ++LAAAD+ V +P + Sbjct: 41 KPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLF-VCTLPLWMQ 99 Query: 65 TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 124 + A C + V +S+ + IA+DRY AI Y +A Sbjct: 100 YLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIV----YMRYRPVKQACLF 155 Query: 125 IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 W+ + I + + K++ + + ++ + M Sbjct: 156 SIFWWIFAVIIAIPHFM-------VVTKKDNQCMTDYDYLEVSYPIILNVELM-----LG 203 Query: 185 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL 244 ++PL ++ Y RI S + + + L +V +F + Sbjct: 204 AFVIPLSVISYCYYRISRIVAV----------------SQSRHKGRIVRVLIAVVLVFII 247 Query: 245 CWLPLHIINCFTFFCPDCSHAPLWLMY--------LAIVLSHTNSVVNPFIYAYRIREFR 296 WLP H+ + L L+ + +NP +Y + +FR Sbjct: 248 FWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFR 307 Query: 297 QTFRKII 303 Q ++ Sbjct: 308 QELHCLL 314 >4Z36-A nrPDB Length = 459 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 97/234 (41%), Gaps = 27/234 (11%) Query: 5 GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI 64 S + + + + + + +L N+LV A+++N Y + +LAAAD G+ F + Sbjct: 66 VSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLA--YFYL 123 Query: 65 TISTGF---CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 121 +TG L + +S+ +LLAIAI+R+I + ++ + ++ R Sbjct: 124 MFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRV 182 Query: 122 KGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFN 181 +I + W ++ +G P +GWN + N + P+ Y Sbjct: 183 VVVIVVIWTMAIVMGAIPSVGWNCICDIENCSN----------------MAPLYSCSYLV 226 Query: 182 FFACV-LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 F+A LV ++M+ +Y IF +E ++K +AA+ Sbjct: 227 FWAIFNLVTFVVMVVLYAHIFGYV----ADLEDNWETLNDNLKVIEKADNAAQV 276 Score = 78.6 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 6/103 (5%) Query: 202 LAARRQLKQMESQPLPGE-RARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCP 260 AA QLK + + R R T+ K++ I++G F +CW P ++ CP Sbjct: 333 QAAAEQLKTTRNAYIQKYLRNRDTMMS---LLKTVVIVLGAFIICWTPGLVLLLLDCCCP 389 Query: 261 DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303 C +L +L+ NS +NP IY+YR +E TFR+I+ Sbjct: 390 QCDVLAYEKFFL--LLAEFNSAMNPIIYSYRDKEMSATFRQIL 430 >5T1A-A nrPDB Length = 508 Score = 121 bits (304), Expect = 5e-28, Method: Composition-based stats. Identities = 38/235 (16%), Positives = 89/235 (37%), Gaps = 14/235 (5%) Query: 4 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63 +G+ + + + + +GN+LV + L+ +T+ ++++LA +D+ + +A Sbjct: 50 IGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWA 109 Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123 + + + C + IF ++ + IDRY+AI + T T Sbjct: 110 HSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVV 169 Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVV-PMNYMVYFNF 182 I W+++ + ++ + C N+ Sbjct: 170 TSVITWLVAVFASVPGIIF------------TKCQKEDSVYVCGPYFPRGWNNFHTIMRN 217 Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 +++PLL+M+ Y I A++ ++ E + E R + K+ ++ I Sbjct: 218 ILGLVLPLLIMVICYSGISRASKSRINIFEMLRI-DEGLRLKIYKDTEGYYTIGI 271 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 46/122 (37%), Gaps = 12/122 (9%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + S +E A + + I+ ++ L W P +I+ Sbjct: 381 YNQTPNRAKRVITTFRTGTWDAYPPPS---REKKAVRVIFTIMIVYFLFWTPYNIVILLN 437 Query: 257 FF--------CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVL 308 F C S + L T+ +NP IYA+ +FR+ R H+ Sbjct: 438 TFQEFFGLSNCESTSQLD-QATQVTETLGMTHCCINPIIYAFVGEKFRRYLSVFFRKHIT 496 Query: 309 RQ 310 ++ Sbjct: 497 KR 498 >4GRV-A nrPDB Length = 510 Score = 120 bits (302), Expect = 7e-28, Method: Composition-based stats. Identities = 48/242 (19%), Positives = 101/242 (41%), Gaps = 19/242 (7%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTN---YFVVSLAAADIAVGVLAIPF 62 + + LA+ V+ +GN + + + +LQ++ + Y + SLA +D+ + +LA+P Sbjct: 32 KVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPV 91 Query: 63 AIT----ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 + + + GC T ++ ++ ++++ RY+AI P + L++ Sbjct: 92 ELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAICHPFKAKTLMSR 151 Query: 119 TRAKGIIAICWVLS--FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACL-FEDVVPMN 175 +R K I+ W+ S AI + +G N + G G + C D + Sbjct: 152 SRTKKFISAIWLASALLAIPMLFTMGLQN--------RSADGTHPGGLVCTPIVDTATVK 203 Query: 176 YMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSL 235 ++ N F L P+L++ + I + E + E R + K+ ++ Sbjct: 204 VVIQVNTFMSFLFPMLVISILNTVIANKLTVMVNIFEMLRI-DEGLRLKIYKDTEGYYTI 262 Query: 236 AI 237 I Sbjct: 263 GI 264 Score = 82.1 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 43/126 (34%), Gaps = 7/126 (5%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + S Q H +V F +CWLP H+ Sbjct: 374 YNQTPNRAKRVITTFRTGTWDAYGSGSV-QALRHGVLVARAVVIAFVVCWLPYHVRRLMF 432 Query: 257 FFCPDCSHAPL------WLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ 310 + D + L L++ +S +NP +Y FRQ F + Sbjct: 433 CYISDEQWTTFLFDFYHYFYMLTNALAYASSAINPILYNLVSANFRQVFLSTLACLCPGW 492 Query: 311 QEPFKA 316 + KA Sbjct: 493 RHRRKA 498 >5O9H-A nrPDB Length = 317 Score = 120 bits (302), Expect = 7e-28, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 102/302 (33%), Gaps = 29/302 (9%) Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIA--VGVLAIPFAIT 65 + + + + ++ +LGN LV W + + + + ++LA AD + + A+ +I Sbjct: 10 LALVIFAVVFLVGVLGNALVVWVTAFEAK-RTINAIWFLNLAVADFLACLALPALFTSIV 68 Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 + C + +L+ +SI L I+ DR++ + P A + Sbjct: 69 QHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPAWCQRFRGAGLAWILC 128 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 A+ W L+ + + L + K D + Sbjct: 129 AVAWGLALLLTIPSALYRVVREEYFPPKVLCGVDY-------SHDKRRERAVAIVRLVLG 181 Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 245 L PLL + Y I L RST K + +V F + Sbjct: 182 FLWPLLTLTICYTFILLRT-----------WSARETRST-----KTLKVVVAVVASFFIF 225 Query: 246 WLPLHIINCFTFFCPDCSHAPLWLM---YLAIVLSHTNSVVNPFIYAYRIREFRQTFRKI 302 WLP + F S L L L + ++ N +NP IY + F+ RK Sbjct: 226 WLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRERKS 285 Query: 303 IR 304 + Sbjct: 286 LP 287 >4XT3-A nrPDB Length = 362 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 51/307 (16%), Positives = 104/307 (33%), Gaps = 42/307 (13%) Query: 6 SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI- 64 V + + + + +GN LV + + +Q + + ++LAAAD+ V +P + Sbjct: 41 KPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLF-VCTLPLWMQ 99 Query: 65 TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 124 + A C + V +S+ + IA+DRY AI Y +A Sbjct: 100 YLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIV----YMRYRPVKQACLF 155 Query: 125 IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 W+ + I + + K++ + + ++ + M Sbjct: 156 SIFWWIFAVIIAIPHFM-------VVTKKDNQCMTDYDYLEVSYPIILNVELM-----LG 203 Query: 185 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFAL 244 ++PL ++ Y RI S + + + L +V +F + Sbjct: 204 AFVIPLSVISYCYYRISRIVAV----------------SQSRHKGRIVRVLIAVVLVFII 247 Query: 245 CWLPLHIINCFTFFCPDCSHAPLWLMY--------LAIVLSHTNSVVNPFIYAYRIREFR 296 WLP H+ + L L+ + +NP +Y + +FR Sbjct: 248 FWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFR 307 Query: 297 QTFRKII 303 Q ++ Sbjct: 308 QELHCLL 314 >3VW7-A nrPDB Length = 484 Score = 111 bits (277), Expect = 7e-25, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 82/230 (35%), Gaps = 10/230 (4%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--- 67 +V + V+++ N++ L ++ +++ LA AD+ V +PF I+ Sbjct: 25 SVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLF-VSVLPFKISYYFSG 83 Query: 68 TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAI 127 + + C F+ +SI + I+IDR++A+ P++ T RA Sbjct: 84 SDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLA 143 Query: 128 CWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL 187 W L+ A + +L P G C + L E Y Sbjct: 144 IWALAIAGVVPLLLKEQTIQVPGLG---ITTCHDVLSETLLEGYYA--YYFSAFSAVFFF 198 Query: 188 VPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 VPL++ Y+ I E + E R + K ++ I Sbjct: 199 VPLIISTVCYVSIIRCLSSSANIFEMLRI-DEGLRLKIYKNTEGYYTIGI 247 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 20/119 (16%), Positives = 43/119 (36%), Gaps = 6/119 (5%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + RS K+ A A + +F +C+ P +++ Sbjct: 357 YNQTPNRAKRVITTFRTGTWDAYANRS---KKSRALFLSAAVFCIFIICFGPTNVLLIAH 413 Query: 257 F---FCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQE 312 + + A + L + +S + ++P IY Y E ++ I+ Sbjct: 414 YSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPS 472 >3OE9-A nrPDB Length = 499 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 39/228 (17%), Positives = 82/228 (35%), Gaps = 15/228 (6%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA-ITISTG 69 T+ I + I+GN LV + L+++T+ + + L+ AD+ V+ +PF + Sbjct: 53 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN 111 Query: 70 FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129 + C + V SS++ L I++DRY+AI K + W Sbjct: 112 WYFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVW 171 Query: 130 VLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189 + + + + + N + V + + +++P Sbjct: 172 IPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVV----------VFQFQHIMVGLILP 221 Query: 190 LLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 +++L Y I + +M E R + K+ ++ I Sbjct: 222 GIVILSCYCIIISKLSHNIFEM---LRIDEGLRLKIYKDTEGYYTIGI 266 Score = 57.0 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 21/118 (17%), Positives = 45/118 (38%), Gaps = 12/118 (10%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHI----- 251 Y + A+R + + + ++ A K I++ F CWLP +I Sbjct: 376 YNQTPNRAKRVITTFRTGTWDAYSG--SGHQKRKALKPTVILILAFFACWLPYYIGISID 433 Query: 252 ----INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRS 305 + C + W+ + L+ + +NP +YA+ +F+ + + + S Sbjct: 434 SFILLEIIKQGCEFENTVHKWI-SITEALAFFHCCLNPILYAFLGAKFKTSAQHALTS 490 >5X33-A nrPDB Length = 523 Score = 98.6 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 44/236 (18%), Positives = 90/236 (38%), Gaps = 17/236 (7%) Query: 8 VYITVELAIA-VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI 66 + + L+++ V+ + GN V W++ ++VT +V A +L PF + Sbjct: 20 LLAMILLSVSMVVGLPGNTFVVWSILKRMRKRSVTA-LMVLNLALADLAVLLTAPFFLHF 78 Query: 67 STG--FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 124 T + GC V +S+ + A+++DR +A+ P + T T A+ + Sbjct: 79 LTWGTWSFGLAGCRLCHYICGVSMYASVLLITAMSLDRSLAVASPFLSQKVRTKTAARWL 138 Query: 125 IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 + W SF + + + + N + C ++ + + F F Sbjct: 139 LVGIWGASFLLATPVLAF----RKVVKLTNETDLCLA-----VYPSDRHKAFHLLFEAFT 189 Query: 185 CVLVPLLLMLGVYLRIFLAARRQ---LKQMESQPLPGERARSTLQKEVHAAKSLAI 237 +VP L+++ Y I R + E + E R + K+ ++ I Sbjct: 190 GFVVPFLIVVASYADISRRLRARGSGSNIFEMLRI-DEGLRLKIYKDTEGYYTIGI 244 Score = 51.6 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 20/100 (20%), Positives = 36/100 (36%), Gaps = 6/100 (6%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCF- 255 Y + A+R + + + S + + + II+ FA WLP H+++ Sbjct: 354 YNQTPNRAKRVITTFRTGTWDAYGSGSRFHRRRRTGRLVVIIILAFAAFWLPYHVVDLVE 413 Query: 256 -----TFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAY 290 + I L+ +S VNP +YA Sbjct: 414 GSRVLAGTLDQSKQQLRNARKVCIALAFLSSSVNPLLYAC 453 >5XJM-A nrPDB Length = 422 Score = 96.7 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 35/226 (15%), Positives = 77/226 (34%), Gaps = 8/226 (3%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG- 69 + I V+ L N++V + V++ ++ +LA AD+ + +A S Sbjct: 16 ILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRY 75 Query: 70 -FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128 + C F+ + +SIF + +++DRY ++ P +A I+ + Sbjct: 76 DWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQ-RRNPWQASYIVPLV 134 Query: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 W ++ L + G N + + + ++ Sbjct: 135 WCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPE-----KYAQWSAGIALMKNILGFII 189 Query: 189 PLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 PL+ + Y I + +E ++K +AA+ Sbjct: 190 PLIFIATCYFGIRKHLLKTNADLEDNWETLNDNLKVIEKADNAAQV 235 Score = 85.1 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 33/114 (28%), Positives = 49/114 (42%), Gaps = 11/114 (9%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF--- 258 AA QLK + + + +V K A +V F +CWLP H++ Sbjct: 297 QAAAEQLKTTRNAYIQKYLKNRITRDQV--LKMAAAVVLAFIICWLPFHVLTFLDALAWM 354 Query: 259 -----CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHV 307 C + L L + AI+L TNS VNPF+Y + F+Q R + R + Sbjct: 355 GVINSCEVIAVIDLALPF-AILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPI 407 >6AK3-B nrPDB Length = 418 Score = 94.0 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 55/297 (18%), Positives = 105/297 (35%), Gaps = 28/297 (9%) Query: 14 LAIAVLAILGNVLVCWAVWLN---SNLQNVTNYF--VVSLAAADIAVGVLAIPFAITIS- 67 + + + +GN L V + + ++ + LA D+ +L P I + Sbjct: 18 ITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYL 77 Query: 68 --TGFCAA---CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 122 + C F + V SS+F A+A++R +AIR P Y + + Sbjct: 78 SKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRITR 137 Query: 123 GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFE-DVVPMNYMVYFN 181 ++ W+ S A L P+LG G G G + + + F Sbjct: 138 AVLLGVWLASLAFALLPVLGVGQYTVQWPGTWCFISTGRGGQGTSSSHNWGNLFFASAFA 197 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLK-QMESQPLPGERARSTLQKEVHAAKSLAIIVG 240 F L+ L + L A + + + + + R T + + L I+ Sbjct: 198 FLG--LLALTVTFSCNLATIKALVDRCRAKATASQSSAQWGRITTETAIQ----LMGIML 251 Query: 241 LFALCWLPLHIINCFTFFCPDC---------SHAPLWLMYLAIVLSHTNSVVNPFIY 288 + ++CW PL I+ F +A+ L+ N +++P++Y Sbjct: 252 VLSVCWSPLLIMMLKMIFQQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVY 308 >5NDD-A nrPDB Length = 619 Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 73/230 (31%), Gaps = 20/230 (8%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--- 67 V + V+A+ N + W + + ++ +LA AD+ V+ P I Sbjct: 209 IVYTIVFVVALPSNGMALWVFLFRTKKKAPAVIYMANLALADLL-SVIWFPLKIAYHIHG 267 Query: 68 TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAI 127 + C + F SI L +++ R I P+ + + +A I I Sbjct: 268 NNWIYGEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIVNPMGH----SRKKANIAIGI 323 Query: 128 ---CWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 W+L + + + P Q+ L D+ + Sbjct: 324 SLAIWLLILLVTIPLYVVKQTIFIPALQITTCHDVLPEQL--LVGDMFNYFLSLA---IG 378 Query: 185 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 L P L Y+ + R L +E ++K +AA+ Sbjct: 379 VFLFPAFLTASAYVLMI----RALADLEDNWETLNDNLKVIEKADNAAQV 424 Score = 58.6 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 51/110 (46%), Gaps = 3/110 (2%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF-CP 260 AA QLK + + ++ +K A K + ++ +C+ P +++ +F Sbjct: 486 QAAAEQLKTTRNAYIQKY-LENSEKKRKRAIKLAVTVAAMYLICFTPSNLLLVVHYFLIK 544 Query: 261 DCSHAPLWLMYL-AIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLR 309 + ++ +Y+ A+ LS NS ++PF+Y + +FR + + +R Sbjct: 545 SQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVR 594 >5NJ6-A nrPDB Length = 437 Score = 90.5 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 73/230 (31%), Gaps = 20/230 (8%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--- 67 V + V+A+ N + W + + ++ +LA AD+ V+ P I Sbjct: 27 IVYTIVFVVALPSNGMALWVFLFRTKKKAPAVIYMANLALADLL-SVIWFPLKIAYHIHG 85 Query: 68 TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAI 127 + C + F SI L +++ R I P+ + + +A I I Sbjct: 86 NNWIYGEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIVNPMGH----SRKKANIAIGI 141 Query: 128 ---CWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 W+L + + + P Q+ L D+ + Sbjct: 142 SLAIWLLILLVTIPLYVVKQTIFIPALQITTCHDVLPEQL--LVGDMFNYFLSLA---IG 196 Query: 185 CVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS 234 L P L Y+ + R L +E ++K +AA+ Sbjct: 197 VFLFPAFLTASAYVLMI----RALADLEDNWETLNDNLKVIEKADNAAQV 242 Score = 57.0 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 51/110 (46%), Gaps = 3/110 (2%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF-CP 260 AA QLK + + ++ +K A K + ++ +C+ P +++ +F Sbjct: 304 QAAAEQLKTTRNAYIQKY-LENSEKKRKRAIKLAVTVAAMYLICFTPSNLLLVVHYFLIK 362 Query: 261 DCSHAPLWLMYL-AIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLR 309 + ++ +Y+ A+ LS NS ++PF+Y + +FR + + +R Sbjct: 363 SQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVR 412 >5ZKQ-A nrPDB Length = 438 Score = 89.4 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 43/239 (17%), Positives = 80/239 (33%), Gaps = 19/239 (7%) Query: 7 SVYITVELAIAVLAILGNVLVCWAVWL---NSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63 +++ V I VL ++ N V W N F+V+L AD+ ++ +P Sbjct: 18 TLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKF-NEIKIFMVNLTMADMLF-LITLPLW 75 Query: 64 ITISTG---FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR 120 I + C C + T S+ L I +RY A+ P++ T R Sbjct: 76 IVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVTRPIKTAQANTRKR 135 Query: 121 AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180 + + WV + + L ++ + + +E +++ Sbjct: 136 GISLSLVIWV-AIVGAASYFLILDSTNTVPDSAGSGDVT---RCFEHYEKGSVPVLIIHI 191 Query: 181 NFFACVLVPLLLMLGVYLRIFLAARRQ-------LKQMESQPLPGERARSTLQKEVHAA 232 + L++L L I Q L+ E G+ A ++V AA Sbjct: 192 FIVFSFFLVFLIILFCNLVIIRTLLMQPVNIFEMLRIDEGGGSGGDEAEKLFNQDVDAA 250 Score = 51.6 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 40/107 (37%), Gaps = 11/107 (10%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + ++ +F +C++P H++ Sbjct: 315 YNQTPNRAKRVITTFRTGTWDAYAEVKR-----RDLWMACTVLAVFIICFVPHHVVQLPW 369 Query: 257 F-----FCPDCSHAPLWLMY-LAIVLSHTNSVVNPFIYAYRIREFRQ 297 F H + + + + L TN V+NP IY + ++FR+ Sbjct: 370 TLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLNPVIYCFLTKKFRK 416 >5ZKP-A nrPDB Length = 466 Score = 88.6 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 71/211 (33%), Gaps = 12/211 (5%) Query: 7 SVYITVELAIAVLAILGNVLVCWAVWL---NSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63 +++ V I VL ++ N V W N F+V+L AD+ ++ +P Sbjct: 18 TLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKF-NEIKIFMVNLTMADMLF-LITLPLW 75 Query: 64 ITISTG---FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR 120 I + C C + T S+ L I +RY A+ P++ T R Sbjct: 76 IVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVTRPIKTAQANTRKR 135 Query: 121 AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180 + + WV + + L ++ + + +E +++ Sbjct: 136 GISLSLVIWV-AIVGAASYFLILDSTNTVPDSAGSGDVT---RCFEHYEKGSVPVLIIHI 191 Query: 181 NFFACVLVPLLLMLGVYLRIFLAARRQLKQM 211 + L++L L I Q K + Sbjct: 192 FIVFSFFLVFLIILFCNLVIIRTLLMQAKAL 222 Score = 51.6 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 33/70 (47%), Gaps = 6/70 (8%) Query: 234 SLAIIVGLFALCWLPLHIINCFTF-----FCPDCSHAPLWLMY-LAIVLSHTNSVVNPFI 287 ++ +F +C++P H++ F H + + + + L TN V+NP I Sbjct: 375 MACTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLNPVI 434 Query: 288 YAYRIREFRQ 297 Y + ++FR+ Sbjct: 435 YCFLTKKFRK 444 >6D26-A nrPDB Length = 470 Score = 80.9 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 38/238 (15%), Positives = 78/238 (32%), Gaps = 28/238 (11%) Query: 17 AVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI---STGFCAA 73 ++L ++ N ++ + V Q V +V+ LA +D+ ++PF + Sbjct: 44 SLLGLVENGVILFVVGCRMR-QTVVTTWVLHLALSDLLASA-SLPFFTYFLAVGHSWELG 101 Query: 74 CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSF 133 C + + +S F L AI++DR + + P+ T A + + W L+ Sbjct: 102 TTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAV 161 Query: 134 AIGLTPMLGWNNCGQPKEGKNHSQGCG------EGQVACLFEDVVPMNYMVYFNFFACVL 187 + + + + + C + F L Sbjct: 162 LNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQAA----LAVSKFLLAFL 217 Query: 188 VPLLLMLGVYLRIFLAAR-------------RQLKQMESQPLPGERARSTLQKEVHAA 232 VPL ++ + + L + L+ E G+ A ++V AA Sbjct: 218 VPLAIIASSHAAVSLRLQHRADLGLQHRNIFEMLRIDEGGGSGGDEAEKLFNQDVDAA 275 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 32/86 (37%), Gaps = 6/86 (6%) Query: 245 CWLPLHIINCFTF---FCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRK 301 CW P H+ + P + L+ NSV NP +Y + + R+ Sbjct: 383 CWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRR 442 Query: 302 IIRS---HVLRQQEPFKAAGTSARVL 324 +R+ VL AG+S VL Sbjct: 443 SLRTVLESVLVDDSELGGAGSSLEVL 468 >4NTJ-A nrPDB Length = 466 Score = 80.5 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 80/239 (33%), Gaps = 20/239 (8%) Query: 4 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTN--YFVVSLAAADIAVGVLAIP 61 + ++ + + + ++ N L + +++ +N F+ + +D+ + +L P Sbjct: 32 ITQVLFPLLYTVLFFVGLITNGLAMRIFF---QIRSKSNFIIFLKNTVISDLLM-ILTFP 87 Query: 62 FAITISTGFCAAC---HGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTG 118 F I C + SI L I IDRY P + + Sbjct: 88 FKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNL 147 Query: 119 TRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMV 178 AK + + W F + L M+ N + K K C + +NY+ Sbjct: 148 LGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKK----CSFLKSEFGLVWHEIVNYIC 203 Query: 179 YFNFFACVLVPLLLMLGVYLRIFLAARR---QLKQMESQPLPGERARSTLQKEVHAAKS 234 F+ L+++ Y I R + +E ++K +AA+ Sbjct: 204 QVIFWINF----LIVIVCYTLITKELYRSYVRTADLEDNWETLNDNLKVIEKADNAAQV 258 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 20/112 (17%), Positives = 40/112 (35%), Gaps = 7/112 (6%) Query: 202 LAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD 261 AA QLK + + + II+ +F +C++P H Sbjct: 320 QAAAEQLKTTRNAYIQKYLRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQT 379 Query: 262 CSHAP-------LWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH 306 ++ + L+ N+ +NPFIY + + FR + +++ Sbjct: 380 RDVFDCTAENTLFYVKESTLWLTSLNACLNPFIYFFLCKSFRNSLISMLKCP 431 >5YWY-A nrPDB Length = 332 Score = 78.6 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 40/294 (13%), Positives = 94/294 (31%), Gaps = 30/294 (10%) Query: 10 ITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYF--VVSLAAADIAVGVLAIPFAITIS 67 +T+ + + ++GN++ + + Q T ++ V L D+ +L P I Sbjct: 21 VTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLLVTDLLGTLLVSPVTIATY 80 Query: 68 TG--FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125 + C + +L + S + + A++++RY+AI Y+ V A + Sbjct: 81 MKGQWPGGQPLCEYSTFILLFFSLSRLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTL 140 Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185 + + P +G + C + + +++ Sbjct: 141 FAVYASNVLFCALPNMGLGSSRLQYP-----------DTWCFIDWTTQVTAHAAYSYMYA 189 Query: 186 VLVPLLLMLGVYLRIFL---AARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLF 242 L++ V + + R + R E+ L + Sbjct: 190 GFSSFLILATVLCNVLVCGALLRMHRQFF----------RRIAGAEIQMVILLIATSLVV 239 Query: 243 ALCWLPLHIINCFTFFCPDCSHAPLWLMY--LAIVLSHTNSVVNPFIYAYRIRE 294 +C +PL + + AI ++ N +++P+IY + Sbjct: 240 LICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKT 293 >6M9T-A nrPDB Length = 537 Score = 75.5 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 43/236 (18%), Positives = 79/236 (33%), Gaps = 14/236 (5%) Query: 14 LAIAVLAILGNVLVCWAVWLN---SNLQNVTNYF--VVSLAAADIAVGVLAIPFAITIS- 67 + + + +GN L V + + ++ + LA D+ +L P I + Sbjct: 68 ITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYL 127 Query: 68 --TGFCAA---CHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 122 + C F + V SS+F A+A++R +AIR P Y + + Sbjct: 128 SKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATR 187 Query: 123 GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFE-DVVPMNYMVYFN 181 ++ W+ A L P+LG G G G + + + F Sbjct: 188 AVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFA 247 Query: 182 FFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 F L+ L + L A + + E R + K+ ++ I Sbjct: 248 FLG--LLALTVTFSCNLATIKALVSRGSNIFEMLRIDEGLRLKIYKDTEGYYTIGI 301 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 37/106 (34%), Gaps = 11/106 (10%) Query: 197 YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFT 256 Y + A+R + + + + E L I+ + ++CW PL I+ Sbjct: 411 YNQTPNRAKRVITTFRTGTWDAYGSWGRITTETAIQ--LMAIMCVLSVCWSPLLIMMLKM 468 Query: 257 FFCPDC---------SHAPLWLMYLAIVLSHTNSVVNPFIYAYRIR 293 F +A+ L+ N +++P++Y + Sbjct: 469 IFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRK 514 >4PHU-A nrPDB Length = 491 Score = 63.9 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 43/235 (18%), Positives = 76/235 (32%), Gaps = 11/235 (4%) Query: 11 TVELAIAVLAILGNVLVCWAVWLNSNLQ-NVTNYFVVSLAAADIAVGVLAIPFAIT---I 66 + +A L NVL ++ L+ + + ++L +D+ + V ++P Sbjct: 23 GLYVAAFALGFPLNVLAIRGATAHARLRLTPSAVYALNLGCSDLLLTV-SLPLKAVEALA 81 Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126 S + C A + L A++ RY+ PL Y + G+ A Sbjct: 82 SGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAARYLGAAFPLGYQAFRRPCYSWGVCA 141 Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCG---EGQVACLFE-DVVPMNYMVYFNF 182 W L L + G G + N S G G CL D + Sbjct: 142 AIWAL-VLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLS 200 Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAI 237 +PL + ++ A R E + E R + K+ ++ I Sbjct: 201 LLLFFLPLAITAFCFVGCLRALARGSNIFEMLRI-DEGLRLKIYKDTEGYYTIGI 254 >6IIU-A nrPDB Length = 484 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 48/342 (14%), Positives = 107/342 (31%), Gaps = 60/342 (17%) Query: 15 AIAVLAILGNVLVCWAVWLNSN--LQNVTNY--FVVSLAAAD----IAVGVLAIPFAITI 66 + V+ + N+L + +++ F+ L D + G + + + Sbjct: 140 SFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAAL 199 Query: 67 STGFCA--ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 124 C C F+ ++ S + A+A +RY+ I P + + RA Sbjct: 200 FEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWAT 259 Query: 125 IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFA 184 + + W + A+GL P+LG G G F + M+ Sbjct: 260 VGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFS---MLGGLSVG 316 Query: 185 CVLVPLLLMLGVYLRIFLAARR-------------------------QLKQMESQPLPG- 218 + + + ++ ++ K + + Sbjct: 317 LSFLLNTVSVATLCHVYHGMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPL 376 Query: 219 --------ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF--------CPDC 262 E + A++L I+V ++CWLPL + T Sbjct: 377 CGVGKDQFEEVEERDSEVEMMAQALGIMVVA-SVCWLPLLVFIAQTVLRNPPAMSPAGQL 435 Query: 263 SHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 S + + + ++ N +++P++Y FR+ + ++ Sbjct: 436 SRTTEKELLIYLRVATWNQILDPWVYIL----FRRAVLRRLQ 473 >2LOT-A nrPDB Length = 64 Score = 33.9 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 14/29 (48%) Query: 7 SVYITVELAIAVLAILGNVLVCWAVWLNS 35 ++ + + + +L GN LV W V+ Sbjct: 29 ALIPAIYMLVFLLGTTGNGLVLWTVFRKK 57 >5XEP-A nrPDB Length = 381 Score = 32.0 bits (71), Expect = 0.45, Method: Composition-based stats. Identities = 14/98 (14%), Positives = 27/98 (27%), Gaps = 1/98 (1%) Query: 141 LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRI 200 +G Q C ++ C F +F + P L +Y Sbjct: 1 MGMRAALTGFAVLMLLQSCSAYKLVCYFTSW-SQYREGVGSFLPDAIQPFLCTHIIYSFA 59 Query: 201 FLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAII 238 +++ L E + L+ K+L + Sbjct: 60 NISSDNMLSTWEWNDESNYDKLNKLKTRNTNLKTLLSV 97 >2I9D-A nrPDB Length = 217 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 24/50 (48%) Query: 30 AVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLF 79 ++ ++ NY +++ A I G L +P A+TI GF H LF Sbjct: 159 SITGTQEKRSGNNYPLLNAGKAIIREGRLVMPIAMTIHHGFIDGHHLSLF 208 >6B3J-R nrPDB Length = 491 Score = 28.5 bits (62), Expect = 5.1, Method: Composition-based stats. Identities = 50/336 (14%), Positives = 105/336 (31%), Gaps = 43/336 (12%) Query: 26 LVCW--AVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAA--CHGCLFIA 81 LV + +L NY ++L A+ I + + + A H + Sbjct: 168 LVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLL 227 Query: 82 CFVLVLTQSSIFSLL--AIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTP 139 + L+ +F L+ +A + Y + + L+ A + + W+ + Sbjct: 228 SYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLL----AFSVFSEQWIFRLYVS--- 280 Query: 140 MLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLR 199 +GW + E + + ++ + V L+ + V Sbjct: 281 -IGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICI 339 Query: 200 IFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFC 259 + + L + + L + +L ++G + F F Sbjct: 340 VVSKLKANL-------MCKTDIKCRL---AKSTLTLIPLLGTHEV---------IFAFVM 380 Query: 260 PDCSHAPLWLMYLAIVLSHTN--SVVNPFIYAYRIREFRQTFRKIIRS------HVLRQQ 311 + + L + L LS T+ ++ +Y + E + FRK H+ R Sbjct: 381 DEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDS 440 Query: 312 E--PFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGV 345 P K +S A GS + + + P G+ Sbjct: 441 SMKPLKCPTSSLSSGATAGSSMYTATCQASCSPAGL 476 >1D0M-A nrPDB Length = 322 Score = 28.5 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 17/51 (33%), Positives = 24/51 (47%), Gaps = 13/51 (25%) Query: 312 EPFKAAGTSARVLAAHG-SDGEQVSLRLNGHPPGVWANGSAPHPERRPNGY 361 +P A G+ A AHG G+QV++ NG PG+ PNG+ Sbjct: 209 DPVDAIGSVANYFKAHGWVKGDQVAVMANGQAPGL------------PNGF 247 >5NX2-A nrPDB Length = 422 Score = 27.7 bits (60), Expect = 8.8, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 49/127 (38%), Gaps = 15/127 (11%) Query: 180 FNFFACVLVPLLLMLGVYLRIFLAA-RRQLKQMESQPLPGERARSTLQKEVHAAKSLAII 238 N++ + +P+L +GV IF+ + ++++ + + L + +L + Sbjct: 284 MNYWLIIRLPILFAIGVNFLIFVRVIAIVVSKLKANLMCKTDIKCRL---AKSTLTLIAL 340 Query: 239 VGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTN--SVVNPFIYAYRIREFR 296 + + F F + + L + L LS T+ ++ +Y + E + Sbjct: 341 LAT---------VEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFANNEVQ 391 Query: 297 QTFRKII 303 FRK Sbjct: 392 LEFRKSW 398 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.318 0.132 0.390 Lambda K H 0.267 0.0404 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,054,830 Number of Sequences: 36641 Number of extensions: 631282 Number of successful extensions: 2556 Number of sequences better than 10.0: 124 Number of HSP's better than 10.0 without gapping: 180 Number of HSP's successfully gapped in prelim test: 44 Number of HSP's that attempted gapping in prelim test: 1779 Number of HSP's gapped (non-prelim): 361 length of query: 412 length of database: 10,336,785 effective HSP length: 99 effective length of query: 313 effective length of database: 6,709,326 effective search space: 2100019038 effective search space used: 2100019038 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.3 bits) S2: 60 (27.7 bits)