BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P28834 (360 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3BLX-A nrPDB 714 0.0 5GRH-B nrPDB 347 5e-96 5YVT-A nrPDB 296 1e-80 3BLV-B nrPDB 278 2e-75 2D1C-A nrPDB 224 4e-59 3ASJ-A nrPDB 209 1e-54 1WPW-A nrPDB 192 1e-49 4Y1P-A nrPDB 187 9e-48 3TY3-A nrPDB 175 3e-44 1XAD-A nrPDB 167 8e-42 1IDM-A nrPDB 164 6e-41 2E5M-A nrPDB 161 5e-40 5HN5-A nrPDB 160 1e-39 2IV0-A nrPDB 155 2e-38 1VLC-A nrPDB 154 7e-38 3U1H-A nrPDB 149 2e-36 1V5B-A nrPDB 149 2e-36 1CNZ-A nrPDB 142 3e-34 2D4V-A nrPDB 141 4e-34 1CM7-A nrPDB 140 9e-34 1HQS-A nrPDB 139 1e-33 3FMX-X nrPDB 139 3e-33 1A05-A nrPDB 133 1e-31 5M2E-A nrPDB 129 2e-30 3DMS-A nrPDB 128 5e-30 3VMK-A nrPDB 127 1e-29 2G4O-A nrPDB 127 1e-29 3VML-A nrPDB 125 2e-29 1XGV-A nrPDB 125 3e-29 1AI3-A nrPDB 124 6e-29 3VMJ-A nrPDB 122 2e-28 6C0E-A nrPDB 120 1e-27 5J32-A nrPDB 115 2e-26 4IWH-A nrPDB 114 7e-26 3UDO-A nrPDB 103 9e-23 5I96-A nrPDB 41 8e-04 1E5F-A nrPDB 33 0.21 6BL1-B nrPDB 32 0.54 3E15-A nrPDB 31 0.80 3AZC-A nrPDB 29 2.5 3S47-A nrPDB 28 8.8 3HR8-A nrPDB 28 9.1 >3BLX-A nrPDB Length = 349 Score = 714 bits (1842), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/349 (100%), Positives = 349/349 (100%) Query: 12 ATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHK 71 ATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHK Sbjct: 1 ATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHK 60 Query: 72 EGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI 131 EGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI Sbjct: 61 EGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI 120 Query: 132 PDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTA 191 PDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTA Sbjct: 121 PDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTA 180 Query: 192 VHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYG 251 VHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYG Sbjct: 181 VHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYG 240 Query: 252 TILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLN 311 TILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLN Sbjct: 241 TILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLN 300 Query: 312 HLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 360 HLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM Sbjct: 301 HLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 349 >5GRH-B nrPDB Length = 354 Score = 347 bits (890), Expect = 5e-96, Method: Compositional matrix adjust. Identities = 170/344 (49%), Positives = 238/344 (69%), Gaps = 4/344 (1%) Query: 17 AERTLP--KKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGV 74 +E+T+P KYGGR TVT+IPGDG+G E+ V+++F +P+D+E +++ +E + Sbjct: 2 SEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDI 61 Query: 75 YEAVESLKRNKIGLKGLWHTPAD-QTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPD 133 A+ +++RN++ LKG T + H S N LR LD+YANV KSL GV TR D Sbjct: 62 RNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKD 121 Query: 134 IDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVH 193 ID++++RENTEGE+S LEHESV GVVESLK++T+ K+ RIA +AF A++ RK VTAVH Sbjct: 122 IDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVH 181 Query: 194 KANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTI 253 KANIMKLGDGLF E+ + YP I ++IVDN +MQ V++P QFDV+V P++YG I Sbjct: 182 KANIMKLGDGLFLQCCREVAAR-YPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNI 240 Query: 254 LGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHL 313 + N+ A L+GGPGLVAGAN+G YAVFE +R+ G I +N+ANPTA +L+S +ML+HL Sbjct: 241 VNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHL 300 Query: 314 GLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357 L+ YAT I KAV ++ T DIGG +T++ ++I + Sbjct: 301 KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHI 344 >5YVT-A nrPDB Length = 339 Score = 296 bits (757), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 156/341 (45%), Positives = 221/341 (64%), Gaps = 10/341 (2%) Query: 26 GGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVY----EAVESL 81 GG TVTLIPGDG+G EI+ +V IF+A PI WE N+ G + EA ES+ Sbjct: 2 GGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESM 61 Query: 82 KRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRE 141 +NK+GLKG TP GH S+N+ LRK D+YANV S++G KT D++++ IRE Sbjct: 62 DKNKMGLKGPLKTPI-AAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRE 120 Query: 142 NTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLG 201 NTEGE+SG+EH V GVV+S+K++T ++RIA FAF++A+ +R +VTAVHKANIM++ Sbjct: 121 NTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMS 180 Query: 202 DGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAAL 261 DGLF E+ + DI + + +D + V P QFDVLV P++YG IL ++ A L Sbjct: 181 DGLFLQKCREVAE-SCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGL 239 Query: 262 IGGPGLVAGANFGRD-YAVFEPGSRH-VGLDIKGQNVANPTAMILSSTLMLNHLGLNEYA 319 IGG G+ N G + A+FE S H DI G+++ANPTA++LS+ +ML H+GL ++A Sbjct: 240 IGGLGVTPSGNIGANGVAIFE--SVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHA 297 Query: 320 TRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 360 RI A TI +GK T+D+GG++ +DFT EI ++ + Sbjct: 298 ARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDL 338 >3BLV-B nrPDB Length = 354 Score = 278 bits (712), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 147/344 (42%), Positives = 221/344 (64%), Gaps = 12/344 (3%) Query: 22 PKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVY----EA 77 P G++TV+ I GDG+G EI+ SV+ IF A N+PI+WE+ ++ G+ A Sbjct: 15 PNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPI-FVNGLTTIPDPA 73 Query: 78 VESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLI 137 V+S+ +N + LKG TP + GH SLN+ LRK ++ANV KS++G KT ++DL+ Sbjct: 74 VQSITKNLVALKGPLATPIGK-GHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLV 132 Query: 138 VIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANI 197 +IRENTEGE+SG+EH PGVV+S+K++TR +ER+ R+AF++A+ R V VHK+ I Sbjct: 133 LIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTI 192 Query: 198 MKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD--VLVTPSMYGTILG 255 +L DGLF N+ E+ KEYPD+ + + ++DN+ ++ V P + V V P++YG IL Sbjct: 193 QRLADGLFVNVAKEL-SKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILS 251 Query: 256 NIGAALIGGP-GLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLG 314 ++ + L G GL AN G ++FE DI GQ+ ANPTA++LSS +MLNH+G Sbjct: 252 DLNSGLSAGSLGLTPSANIGHKISIFE-AVHGSAPDIAGQDKANPTALLLSSVMMLNHMG 310 Query: 315 LNEYATRISKAVHETIAEG-KHTTRDIGGSSSTTDFTNEIINKL 357 L +A +I AV TIA G ++ T D+ G+++T+ FT +I +L Sbjct: 311 LTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL 354 >2D1C-A nrPDB Length = 496 Score = 224 bits (572), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 132/343 (38%), Positives = 195/343 (56%), Gaps = 17/343 (4%) Query: 27 GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGV-----YEAVESL 81 GR +T+IPGDG+G E ++ + EA P+ +E + + G+ E +ES+ Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESI 77 Query: 82 KRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPD--IDLIVI 139 ++ ++ LKG TP G S NV LRK + YANV + V T IDL+V+ Sbjct: 78 RKTRVVLKGPLETPVGY-GEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVV 136 Query: 140 RENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMK 199 REN E ++G+EH P V ++LK+++ +E+I RFAF+ A+ RK V K+NIMK Sbjct: 137 RENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMK 196 Query: 200 LGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGA 259 L +G + ++ Q EYPDI+ IIVDNA+ Q V +P QF+V+VT +M G IL ++ + Sbjct: 197 LAEGTLKRAFEQVAQ-EYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTS 255 Query: 260 ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYA 319 LIGG G AN G + A+FE G+NV NPTA++LS+ +ML + L E+A Sbjct: 256 GLIGGLGFAPSANIGNEVAIFE-AVHGSAPKYAGKNVINPTAVLLSAVMMLRY--LEEFA 312 Query: 320 TR--ISKAVHETIAEGKHTTRDIGG---SSSTTDFTNEIINKL 357 T I A+ T+ EG+ T D+ G + TT++T II L Sbjct: 313 TADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNL 355 >3ASJ-A nrPDB Length = 334 Score = 209 bits (532), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 128/343 (37%), Positives = 194/343 (56%), Gaps = 22/343 (6%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIPID-------WETINIKQTDHKEGVYEAVESL 81 + + LI GDG+G E+ + R + EA +P++ WET + T E E VE + Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEATGLPLEFVEAEAGWETFERRGTSVPE---ETVEKI 59 Query: 82 KRNKIGLKGLWHTPADQTG--HGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVI 139 L G +P + G++ LR++LD+YANV KS + V P +DL+++ Sbjct: 60 LSCHATLFGAATSPTRKVPGFFGAIRY-LRRRLDLYANVRPAKS-RPVPGSRPGVDLVIV 117 Query: 140 RENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMK 199 RENTEG + E + V + V+++ +ERI R A A+ RK++ HKAN++ Sbjct: 118 RENTEGLYVEQERRYL-DVAIADAVISKKASERIGRAALRIAEGRPRKTLHIAHKANVLP 176 Query: 200 LGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGA 259 L GLF + + E+ K++P ++V IIVDN +MQ V +P +FDV+VT ++ G IL ++ A Sbjct: 177 LTQGLFLDTVKEVA-KDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAA 235 Query: 260 ALIGGPGLVAGANFGRDYAVFEP--GSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNE 317 L+GG GL N G AVFEP GS DI G+ +ANPTA ILS+ +ML++LG E Sbjct: 236 GLVGGLGLAPSGNIGDTTAVFEPVHGS---APDIAGKGIANPTAAILSAAMMLDYLGEKE 292 Query: 318 YATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 360 A R+ KAV + G T D+GG ++T FT ++ L ++ Sbjct: 293 AAKRVEKAVDLVLERGPRTP-DLGGDATTEAFTEAVVEALKSL 334 >1WPW-A nrPDB Length = 336 Score = 192 bits (489), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 129/348 (37%), Positives = 193/348 (55%), Gaps = 33/348 (9%) Query: 29 FTVTLIPGDGVGKEITDSVRTIF----EAENIPIDWETINIKQTDHKEGVY-EAV--ESL 81 FTV LI GDG+G EI + I E ++PI++ I ++ D Y EA+ +SL Sbjct: 2 FTVALIQGDGIGPEIVSKSKRILAKINELYSLPIEY--IEVEAGDRALARYGEALPKDSL 59 Query: 82 K---RNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIV 138 K + I LKG P ++ + V LR+ D+YAN+ KS+ G+ T+ ++D+++ Sbjct: 60 KIIDKADIILKG----PVGESA-ADVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILI 114 Query: 139 IRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIM 198 +RENTE + G EH GV +K++TR +ERIA+ +FA + RK VT VHKAN+M Sbjct: 115 VRENTEDLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALR-RRKKVTCVHKANVM 173 Query: 199 KLGDGLFRNIITEI--GQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGN 256 ++ DGLF + G+ EY S + VD A+ V P FDV+VT ++YG IL + Sbjct: 174 RITDGLFAEACRSVLKGKVEY-----SEMYVDAAAANLVRNPQMFDVIVTENVYGDILSD 228 Query: 257 IGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLM---LNHL 313 + + G G+ AN G A+FEP DI G+N+ NPTA +LS ++M + L Sbjct: 229 EASQIAGSLGIAPSANIGDKKALFEP-VHGAAFDIAGKNIGNPTAFLLSVSMMYERMYEL 287 Query: 314 GLNEYATRISKAVHETI----AEGKHTTRDIGGSSSTTDFTNEIINKL 357 ++ + S+A+ I E K T D+GG+++T D NEI NKL Sbjct: 288 SNDDRYIKASRALENAIYLVYKERKALTPDVGGNATTDDLINEIYNKL 335 >4Y1P-A nrPDB Length = 337 Score = 187 bits (474), Expect = 9e-48, Method: Compositional matrix adjust. Identities = 123/351 (35%), Positives = 192/351 (54%), Gaps = 39/351 (11%) Query: 29 FTVTLIPGDGVGKEITDSVRTIF----EAENIPIDWETINIKQTDHKEGVY------EAV 78 F V LI GDG+G E+ +TI E ++PI++ I ++ D + + +++ Sbjct: 3 FVVALIQGDGIGPEVVSKSKTILARLNEKFSLPIEY--IEVEAGDTTKNKFGDALPKDSL 60 Query: 79 ESLKRNKIGLKG-LWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLI 137 +++ + LKG + T AD V LR D+YAN+ KSL G++ + D+D++ Sbjct: 61 RVIEKADMILKGPVGETAADVV------VKLRLMYDLYANLRPAKSLPGLENKFGDVDIL 114 Query: 138 VIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANI 197 V+RENTE + GLEH GV +KV+TR + RIA+ A + A + +K V VHK+N+ Sbjct: 115 VVRENTEDLYKGLEHVISDGVTVGIKVITRAASTRIAQVALNQALR-RKKKVVCVHKSNV 173 Query: 198 MKLGDGLF----RNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTI 253 M++ DGLF RN++ G+ EY S + VD A+ V P FDV+VT + YG I Sbjct: 174 MRITDGLFAESCRNVLK--GKVEY-----SEMYVDAAAANLVRNPQAFDVIVTENTYGDI 226 Query: 254 LGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHL 313 L + + G G+ AN G ++FEP DI G+N+ANPTA +LS +ML+ + Sbjct: 227 LSDEAGQIAGSLGISPSANIGDRKSLFEP-VHGAAFDIAGKNIANPTAFLLSVGMMLDRM 285 Query: 314 G-------LNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357 N A + A++ +EGK+ T D+GGSS+T + + I +K+ Sbjct: 286 QELSGDIRYNNAAKSLRDAIYSVYSEGKYLTPDVGGSSTTDEMISAIRSKI 336 >3TY3-A nrPDB Length = 366 Score = 175 bits (443), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 124/362 (34%), Positives = 189/362 (52%), Gaps = 45/362 (12%) Query: 28 RFTVTLIPGDGVGKEITDSVRTIFEAENIP----IDWETINIKQTDHKEGVYE------- 76 R + LIP DG+GKE+ + R + E N+P + ++ I++ D G +E Sbjct: 10 RIVLGLIPADGIGKEVVPAARRLME--NLPAKHKLKFDFIDL---DAGWGTFERTGKALP 64 Query: 77 --AVESLK-RNKIGLKGLWHTPADQ-TGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP 132 VE LK L G +P + G+ S VALRK++ +YANV KSL G K + Sbjct: 65 ERTVERLKTECNAALFGAVQSPTHKVAGYSSPIVALRKKMGLYANVRPVKSLDGAKGK-- 122 Query: 133 DIDLIVIRENTEGEFSGLEH--ESVPG--VVESLKVMTRPKTERIARFAFDFAKK----- 183 +DL+++RENTE + E ++ PG V E+++ ++ + +I + AF+ AK Sbjct: 123 PVDLVIVRENTECLYVKEERMVQNTPGKRVAEAIRRISEEASTKIGKMAFEIAKSRQKIR 182 Query: 184 -------YNRKSVTAVHKANIMKLGDGLFRNII--TEIGQKEYPDIDVSSIIVDNASMQA 234 + + VT +HK+N+M + DGLFR + Y I+V IVD+ + Sbjct: 183 ESGTYSIHKKPLVTIIHKSNVMSVTDGLFRESCRHAQSLDPSYASINVDEQIVDSMVYRL 242 Query: 235 VAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEP--GSRHVGLDIK 292 +P FDV+V P++YG IL + A+LIG GLV AN G ++ + EP GS DI Sbjct: 243 FREPECFDVVVAPNLYGDILSDGAASLIGSLGLVPSANVGDNFVMSEPVHGS---APDIA 299 Query: 293 GQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNE 352 G+ +ANP A S LML +G + A I AV + + EGK T D+GG S T + T+ Sbjct: 300 GRGIANPVATFRSVALMLEFMGHQDAAADIYTAVDKVLTEGKVLTPDLGGKSGTNEITDA 359 Query: 353 II 354 ++ Sbjct: 360 VL 361 >1XAD-A nrPDB Length = 345 Score = 167 bits (422), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 118/353 (33%), Positives = 192/353 (54%), Gaps = 35/353 (9%) Query: 31 VTLIPGDGVGKEITDS----VRTIFEAENIPIDWETINIK-----------QTDHKEGVY 75 V ++PGDG+G E+T++ +R + EAE + + +E ++GV Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVE 62 Query: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYAN---VALFKSLKGV----K 128 EA E++ +G P + L +++RKQLD++AN V +F+SL K Sbjct: 63 EA-EAVLLGSVGGPKWDQNPRELRPEKGL-LSIRKQLDLFANLRPVKVFESLSDASPLKK 120 Query: 129 TRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKS 188 I ++D +++RE T G + G + + ++P+ ER+AR AF+ A+K RK Sbjct: 121 EYIDNVDFVIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARK-RRKH 179 Query: 189 VTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPS 248 V +V KAN++++G+ +R + E+G+ YPD+ + VD +M V P +FDV+VT + Sbjct: 180 VVSVDKANVLEVGE-FWRKTVEEVGRG-YPDVALEHQYVDAMAMHLVRSPARFDVVVTGN 237 Query: 249 MYGTILGNIGAALIGGPGLVAGANFGRDYAVFEP--GSRHVGLDIKGQNVANPTAMILSS 306 ++G IL ++ + L G GL+ A+ GR VFEP GS DI G+ +ANPTA ILS+ Sbjct: 238 IFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGS---APDIAGKGIANPTAAILSA 294 Query: 307 TLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLS 358 +ML H GL E A ++ AV + + E D+GGS+ T FT ++ L+ Sbjct: 295 AMMLEHAFGLVELARKVEDAVAKALLE--TPPPDLGGSAGTEAFTATVLRHLA 345 >1IDM-A nrPDB Length = 343 Score = 164 bits (415), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 117/353 (33%), Positives = 189/353 (53%), Gaps = 37/353 (10%) Query: 31 VTLIPGDGVGKEITDS----VRTIFEAENIPIDWETINIK-----------QTDHKEGVY 75 V ++PGDG+G E+T++ +R + EAE + + +E ++GV Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVE 62 Query: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP--- 132 EA L + G K W T + + G L+ LRK D++AN+ K G++ P Sbjct: 63 EAEAVLLGSVGGPK--WGTGSVRPEQGLLS--LRKSQDLFANLRPAKVFPGLERLSPLKE 118 Query: 133 ----DIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKS 188 +D++++RE T G + G + + ++P+ ER+AR AF+ A+K RK Sbjct: 119 EIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARK-RRKH 177 Query: 189 VTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPS 248 V +V KAN++++G+ +R + E+G+ YPD+ + VD +M V P +FDV+VT + Sbjct: 178 VVSVDKANVLEVGE-FWRKTVEEVGRG-YPDVALEHQYVDAMAMHLVRSPARFDVVVTGN 235 Query: 249 MYGTILGNIGAALIGGPGLVAGANFGRDYAVFEP--GSRHVGLDIKGQNVANPTAMILSS 306 ++G IL ++ + L G GL+ A+ GR VFEP GS DI G+ +ANPTA ILS+ Sbjct: 236 IFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAP---DIAGKGIANPTAAILSA 292 Query: 307 TLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLS 358 +ML H GL E A ++ AV + + E D+GGS+ T FT ++ L+ Sbjct: 293 AMMLEHAFGLVELARKVEDAVAKALLE--TPPPDLGGSAGTEAFTATVLRHLA 343 >2E5M-A nrPDB Length = 409 Score = 161 bits (407), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 119/389 (30%), Positives = 195/389 (50%), Gaps = 63/389 (16%) Query: 30 TVTLIPGDGVGKEITDS-VRTIFEA------ENIPIDWETINIKQTDHK----EGVYEAV 78 + I GDG+G EIT++ ++ I +A + I W + + K E Sbjct: 26 VILYIEGDGIGPEITNAAIKVINKAVERAYGSSREIKWLEVYAGEKAEKLVNDRFPKETQ 85 Query: 79 ESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI--PD-ID 135 E L + ++ LKG TP + G S+NVA+R LD+YAN+ K ++G+++ + P+ +D Sbjct: 86 EMLLKYRVVLKGPLETPIGK-GWKSVNVAIRLMLDLYANIRPVKYIEGLESPLKHPEKVD 144 Query: 136 LIVIRENTEGEFSGLEH----------------------ESVPGVVESLKVMTRPKTERI 173 +I+ RENT+ + G+E+ E G+ +KVM++ KT+RI Sbjct: 145 MIIFRENTDDLYRGIEYPFNSEEAKKIRDFLRKELKVEIEDDTGI--GIKVMSKYKTQRI 202 Query: 174 ARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD-------------- 219 R A +A ++ RK VT +HK N+MK +G FR E+ KEY D Sbjct: 203 TRLAIQYAIEHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKEYRDFIVTEEEINQGKPD 262 Query: 220 ---IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD 276 I ++ I DN Q + +P ++D+++ P++ G + + ALIG G++ GAN G + Sbjct: 263 QGKIILNDRIADNMFQQIIIRPEEYDIILAPNVNGDYISDAAGALIGNIGMLGGANIGDE 322 Query: 277 YAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHT 336 +FE G+NVANPT +I + LML +G NE A I KA++ I + K Sbjct: 323 GGMFE-AIHGTAPKYAGKNVANPTGIIKAGELMLRWMGWNEAADLIEKAINMAIRD-KKV 380 Query: 337 TRDIG-----GSSSTTDFTNEIINKLSTM 360 T+DI + T ++ +E+I + T+ Sbjct: 381 TQDIARFMGVKALGTKEYADELIKIMDTI 409 >5HN5-A nrPDB Length = 353 Score = 160 bits (404), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 108/338 (31%), Positives = 184/338 (54%), Gaps = 23/338 (6%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIPIDWET----INIKQTDHKEGVYEAVESLKRN 84 + V +IPGDG+G E+ D + +A + +E +++ Q E +E ++R+ Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGRVRFEYYEGGVDVFQECGSPIREEDLEEIRRS 61 Query: 85 KIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTE 144 L G TP D G+ SL + LRK+L +YAN+ + L+ + +++++REN+E Sbjct: 62 DAVLFGATTTPFDLPGYRSLILTLRKELGLYANLRIIPDLRTGR------EIVIVRENSE 115 Query: 145 GEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGL 204 G + G+ V G ++++TR ERIARFA + AK +T VHKAN++ GD Sbjct: 116 GLYFGI-GAVVNGRAVDVRLITREGAERIARFAVEQAKARG-SFITFVHKANVLT-GDKF 172 Query: 205 FRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGG 264 FR I+ E+ +E ++V I+D+ +++ V P + V+++ +++G IL ++ G Sbjct: 173 FRRIVREVAGEE--GVEVRDAIIDSFTIKLVRNPWEHGVILSENLFGDILSDLATVHAGS 230 Query: 265 PGLVAGANFGRDYAVFEP--GSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRI 322 G+V N+G A+FEP GS DI G+ +ANP ILS ++L++LGL+ + I Sbjct: 231 IGIVPSGNYGDGIALFEPVHGSAP---DIAGKGIANPIGAILSGAMLLDYLGLD--GSLI 285 Query: 323 SKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 360 AV + G+ T D+GG + T D II ++ + Sbjct: 286 RAAVRGYVVNGELTP-DMGGRARTEDVVRGIIGEIEDL 322 >2IV0-A nrPDB Length = 412 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 123/390 (31%), Positives = 187/390 (47%), Gaps = 67/390 (17%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVY---------EAVESL 81 + GDG+GK++ + + +A I E + Q E Y + + ++ Sbjct: 30 IPYFEGDGIGKDVVPAAIRVLDAAADKIGKEVVWF-QVYAGEDAYKLYGNYLPDDTLNAI 88 Query: 82 KRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI--PD-IDLIV 138 K ++ LKG TP G+ SLNV +R+ LD+YANV LKGV + I P+ ++ ++ Sbjct: 89 KEFRVALKGPLTTPVG-GGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKVNFVI 147 Query: 139 IRENTEGEFSGLEHESVPGVVESLKVMTRPK----------------------TERIARF 176 RENTE ++G+E G E+LK++ K T+R+ R Sbjct: 148 FRENTEDVYAGIEWPR--GSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFATKRLVRM 205 Query: 177 AFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD----------------- 219 A +A + NRKSVT VHK NIMK +G FR+ E+ ++E+ + Sbjct: 206 AIRYAIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQEFGEYCITEDELWDKYGGKQP 265 Query: 220 ---IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD 276 I V I DN Q + + ++DV+ P++ G L + AALIGG G+ G+N G Sbjct: 266 EGKIVVKDRIADNMFQQILTRTDEYDVIALPNLNGDYLSDAAAALIGGLGIAPGSNIGDG 325 Query: 277 YAVFEP--GSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGK 334 VFEP GS GQN NPTA IL+ LM ++G + + I KAV TI+ G Sbjct: 326 IGVFEPVHGS---APKYAGQNKVNPTAEILTGALMFEYIGWKDASEMIKKAVEMTISSGI 382 Query: 335 HTT---RDIGGSS-STTDFTNEIINKLSTM 360 T R +GG+ T +F ++ L ++ Sbjct: 383 VTYDIHRHMGGTKVGTREFAEAVVENLQSL 412 >1VLC-A nrPDB Length = 366 Score = 154 bits (388), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 107/272 (39%), Positives = 159/272 (58%), Gaps = 27/272 (9%) Query: 106 VALRKQLDIYANV---ALFKSLKGV---KTRI--PDIDLIVIRENTEGEF----SGLEHE 153 +ALRK L++YAN+ +++SL V K ++ +DL+ +RE + G + GL+ E Sbjct: 104 LALRKMLNLYANIRPIKVYRSLVHVSPLKEKVIGSGVDLVTVRELSYGVYYGQPRGLDEE 163 Query: 154 SVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIG 213 + + R ERIAR AF+ AK RK VT+V KAN++ L+R ++ E+ Sbjct: 164 KGFDTM----IYDRKTVERIARTAFEIAKN-RRKKVTSVDKANVL-YSSMLWRKVVNEVA 217 Query: 214 QKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANF 273 +EYPD++++ I VDNA+MQ + KP QFDV++T +M+G IL + AAL G GL+ A+F Sbjct: 218 -REYPDVELTHIYVDNAAMQLILKPSQFDVILTTNMFGDILSDESAALPGSLGLLPSASF 276 Query: 274 GRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNH-LGLNEYATRISKAVHETIAE 332 G D ++EP DI G+N+ANP A ILS +ML H G+ E A +I +AV I E Sbjct: 277 G-DKNLYEPAGGSAP-DIAGKNIANPIAQILSLAMMLEHSFGMVEEARKIERAVELVIEE 334 Query: 333 GKHTTRDIG----GSSSTTDFTNEIINKLSTM 360 G + TRDI + ST+ + I KL + Sbjct: 335 G-YRTRDIAEDPEKAVSTSQMGDLICKKLEEI 365 >3U1H-A nrPDB Length = 390 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 122/366 (33%), Positives = 192/366 (52%), Gaps = 46/366 (12%) Query: 31 VTLIPGDGVGKEITDSVRTI-----------FEAENIPIDWETINIKQTDHKEGVYEAVE 79 + ++PGDG+G E+ ++ + FE E I I+ T E + Sbjct: 26 IAVLPGDGIGPEVMEAAIEVLKAVAERFGHEFEFEYGLIGGAAIDEAGTPLPEETLDVCR 85 Query: 80 SLKRNKIGLKG--LW-HTPADQTGHGSLNVALRKQLDIYAN---VALFKSLKGV----KT 129 +G G W P++ L + +RK LD++AN V ++ SL K Sbjct: 86 GSDAILLGAVGGPKWDQNPSELRPEKGL-LGIRKGLDLFANLRPVKVYDSLADASPLKKE 144 Query: 130 RIPDIDLIVIRENTEGEFSGLEHESVP----GVVESLKVMTRPKTERIARFAFDFAKKYN 185 I +DL+++RE T G + G E V++L + TR + ERI R AF+ A Sbjct: 145 VIEGVDLVIVRELTGGLYFGEPSERYEEGEEAAVDTL-LYTREEIERIIRKAFELALT-R 202 Query: 186 RKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLV 245 +K VT+V KAN+++ L+R + E+ KEYPD+++ ++VDNA+MQ + P QFDV+V Sbjct: 203 KKKVTSVDKANVLE-SSRLWREVAEEVA-KEYPDVELEHMLVDNAAMQLIRNPRQFDVIV 260 Query: 246 TPSMYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEP--GSRHVGLDIKGQNVANPTAM 302 T +M+G IL + + + G G++ A+ D ++EP GS DI G+ +ANP A Sbjct: 261 TENMFGDILSDEASMITGSLGMLPSASLSTDGLGLYEPVHGSAP---DIAGKGIANPLAT 317 Query: 303 ILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI----GGSSSTTDFTNE----I 353 ILS+ +ML + GL E A I KAV + +AEG + T DI G STT+ T+E + Sbjct: 318 ILSAAMMLRYSFGLEEEAKAIEKAVEKVLAEG-YRTADIAKPGGKYVSTTEMTDEVKAAV 376 Query: 354 INKLST 359 +++L+T Sbjct: 377 VDELAT 382 >1V5B-A nrPDB Length = 366 Score = 149 bits (375), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 118/367 (32%), Positives = 196/367 (53%), Gaps = 48/367 (13%) Query: 28 RFTVTLIPGDGVGKEITDS----VRTIFEA-------ENIPIDWETINIKQTDHKEGVYE 76 + + ++PGDG+G E+ D+ ++T+ + EN I I+ T E E Sbjct: 2 KMKLAVLPGDGIGPEVMDAAIRVLKTVLDNDGHEAVFENALIGGAAIDEAGTPLPE---E 58 Query: 77 AVESLKRNKIGLKGL-----W-HTPADQTGHGSLNVALRKQLDIYANVALFKSLKGV--- 127 ++ +R+ L G W H PA L + LRK++ ++AN+ K+ + Sbjct: 59 TLDICRRSDAILLGAVGGPKWDHNPASLRPEKGL-LGLRKEMGLFANLRPVKAYATLLNA 117 Query: 128 ----KTRIPDIDLIVIRENTEGEFSGLEHESV-PG---VVESLKVMTRPKTERIARFAFD 179 + R+ ++DL+++RE T G + G E PG VV++L TR + ERI AF Sbjct: 118 SPLKRERVENVDLVIVRELTGGLYFGRPSERRGPGENEVVDTL-AYTREEIERIIEKAFQ 176 Query: 180 FAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPH 239 A+ RK + +V KAN+++ ++R I E +K YPD+++S ++VD+ +MQ +A P Sbjct: 177 LAQ-IRRKKLASVDKANVLE-SSRMWREIAEETAKK-YPDVELSHMLVDSTAMQLIANPG 233 Query: 240 QFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEP--GSRHVGLDIKGQNV 296 QFDV+VT +M+G IL ++ + + G G++ A+ D + ++EP GS DI GQ Sbjct: 234 QFDVIVTENMFGDILSDLASVITGSLGMLPSASLRSDRFGMYEPVHGS---APDIAGQGK 290 Query: 297 ANPTAMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI----GGSSSTTDFTN 351 ANP +LS+ LML + GL + A I KAV + + +G + T D+ G ST + T+ Sbjct: 291 ANPLGTVLSAALMLRYSFGLEKEAAAIEKAVDDVLQDG-YCTGDLQVANGKVVSTIELTD 349 Query: 352 EIINKLS 358 +I KL+ Sbjct: 350 RLIEKLN 356 >1CNZ-A nrPDB Length = 363 Score = 142 bits (357), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 111/359 (30%), Positives = 188/359 (52%), Gaps = 37/359 (10%) Query: 29 FTVTLIPGDGVGKEIT-------DSVRTIFEAENIPIDWETINIKQTDHKEGVYEA-VES 80 + + ++PGDG+G E+ D+VR+ F+ ++ I +H + +A VE Sbjct: 5 YHIAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSHYDVGGIAIDNHGHPLPKATVEG 64 Query: 81 LKRNKIGLKGL-----WHT--PADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP- 132 ++ L G W P Q G+L + LRK +++N+ K +G++ P Sbjct: 65 CEQADAILFGSVGGPKWENLPPESQPERGAL-LPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 Query: 133 --DI-----DLIVIRENTEGEF----SGLEHESVPGVVESLKVMTRPKTERIARFAFDFA 181 DI D++ +RE T G + G E +V R + ERIAR AF+ A Sbjct: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 Query: 182 KKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQF 241 +K RK VT++ KAN+++ L+R I+ ++ K YPD++++ + +DNA+MQ + P QF Sbjct: 184 RKRRRK-VTSIDKANVLQ-SSILWREIVNDVA-KTYPDVELAHMYIDNATMQLIKDPSQF 240 Query: 242 DVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEPGSRHVGLDIKGQNVANPT 300 DVL+ +++G IL + A + G G++ A+ + ++EP DI G+N+ANP Sbjct: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAP-DIAGKNIANPI 299 Query: 301 AMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI--GGSSSTTDFTNEIINK 356 A ILS L+L + L N+ AT I +A++ + EG T D+ G ++ +TD +II + Sbjct: 300 AQILSLALLLRYSLDANDAATAIEQAINRALEEGVRTG-DLARGAAAVSTDEMGDIIAR 357 >2D4V-A nrPDB Length = 429 Score = 141 bits (356), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 109/404 (26%), Positives = 188/404 (46%), Gaps = 80/404 (19%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTD---HKEGVY---EA 77 + I GDG+G ++T ++R++ +A I W + Q + EG Y E Sbjct: 29 IPFIEGDGIGCDVTPAMRSVVDAAVAKVYGGQRQIAWMELFAGQKAVQLYGEGQYLPDET 88 Query: 78 VESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKT--RIPD-I 134 + +++ K+ +KG TP G SLNVA+R+ LD+Y + + +G + R P+ + Sbjct: 89 MAAIREYKVAIKGPLETPVG-GGIRSLNVAMRQDLDLYVCLRPVRYFEGTPSPMRHPEKV 147 Query: 135 DLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLKVMTRPKTE 171 D+++ REN+E ++G+E + E +K ++ +E Sbjct: 148 DMVIFRENSEDIYAGIEWPAGSPEAEKIIRFLREEMGVTKIRFPDSSAIGIKPVSTEGSE 207 Query: 172 RIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYP------------- 218 R+ R +A ++ + SV+ VHK NIMK +G FR+ + ++E+ Sbjct: 208 RLIRRTIQYALEHGKPSVSLVHKGNIMKFTEGGFRDWGYALAEREFAGRVFTWRQKAAIS 267 Query: 219 -------------------DIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGA 259 + + +I DN Q + +P + V+ T ++ G + + A Sbjct: 268 KAEGKAAGQKAEQQAIADGKLIIKDVIADNFLQQILLRPEDYSVVATLNLNGDYVSDALA 327 Query: 260 ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYA 319 A +GG G+ GAN +A+FE + DI GQ ANP+++ILS+ +ML HLG E A Sbjct: 328 AEVGGIGMAPGANLSDTHAIFE-ATHGTAPDIAGQGKANPSSLILSAVMMLEHLGWGEAA 386 Query: 320 TRISKAVHETIAEGKHTTRDIGG------SSSTTDFTNEIINKL 357 I A++ TIA G+ T D+ + STT+FT +I + Sbjct: 387 QAIVAAMNATIAAGE-VTGDLAALRGDVPALSTTEFTAALIRRF 429 >1CM7-A nrPDB Length = 363 Score = 140 bits (353), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 109/358 (30%), Positives = 183/358 (51%), Gaps = 35/358 (9%) Query: 29 FTVTLIPGDGVGKEIT-------DSVRTIFEAENIPIDWETINIKQTDHKEGVYEA-VES 80 + + ++PGDG+G E+ D+VR F ++ +H + + A VE Sbjct: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Query: 81 LKRNKIGLKGL-----W-HTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 ++ L G W H P DQ + LRK +++N+ K +G++ P Sbjct: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 Query: 133 -DI-----DLIVIRENTEGEF----SGLEHESVPGVVESLKVMTRPKTERIARFAFDFAK 182 DI D++ +RE T G + G E +V R + ERIAR AF+ A+ Sbjct: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 Query: 183 KYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD 242 K R VT++ KAN+++ L+R I+ EI EYPD++++ + +DNA+MQ + P QFD Sbjct: 185 K-RRHKVTSIDKANVLQ-SSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIKDPSQFD 241 Query: 243 VLVTPSMYGTILGNIGAALIGGPGLVAGANFG-RDYAVFEPGSRHVGLDIKGQNVANPTA 301 VL+ +++G IL + A + G G++ A+ + + ++EP DI G+N+ANP A Sbjct: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAP-DIAGKNIANPIA 300 Query: 302 MILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI--GGSSSTTDFTNEIINK 356 ILS L+L + L ++ A I +A++ + EG T D+ G ++ +TD +II + Sbjct: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTG-DLARGAAAVSTDEMGDIIAR 357 >1HQS-A nrPDB Length = 423 Score = 139 bits (351), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 117/407 (28%), Positives = 190/407 (46%), Gaps = 86/407 (21%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTDH-KEGVY---EAVE 79 + I GDG G +I ++ + EA I W+ + + + K G + E ++ Sbjct: 22 IPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLD 81 Query: 80 SLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKT---RIPDIDL 136 ++ I +KG TP G SLNVALR++LD++ + + GV + R D D+ Sbjct: 82 VIREYFIAIKGPLTTPVG-GGIRSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDM 140 Query: 137 IVIRENTEGEFSGLEH----ESVPGVVESL-------------------KVMTRPKTERI 173 ++ RENTE ++G+E+ E V ++ L K ++ T R+ Sbjct: 141 VIFRENTEDIYAGIEYAKGSEEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRL 200 Query: 174 ARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD-------------- 219 R A D+A ++ RKSVT VHK NIMK +G F+N E+ +KEY D Sbjct: 201 VRAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEE 260 Query: 220 ------------------IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAAL 261 I + I D Q + +P++FDV+ T ++ G + + AA Sbjct: 261 QGKDAANKAQSEAEAAGKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQ 320 Query: 262 IGGPGLVAGANFGRD--YAVFEP----GSRHVGLDIKGQNVANPTAMILSSTLMLNHLGL 315 +GG G+ GAN + +A+FE ++ GLD NP+++ILS L+L HLG Sbjct: 321 VGGIGIAPGANINYETGHAIFEATHGTAPKYAGLD-----KVNPSSVILSGVLLLEHLGW 375 Query: 316 NEYATRISKAVHETIAEGKHT---TRDIGGSSS--TTDFTNEIINKL 357 NE A + K++ +TIA T R + G++ ++F E+I + Sbjct: 376 NEAADLVIKSMEKTIASKVVTYDFARLMDGATEVKCSEFGEELIKNM 422 >3FMX-X nrPDB Length = 364 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 118/367 (32%), Positives = 179/367 (48%), Gaps = 44/367 (11%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWETINIKQTDH-----KEGVYEAVE 79 F + IPGDG+G E+ + EA + ++++T D+ K + E Sbjct: 6 FRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDDWAE 65 Query: 80 SLKRNKIGLKGLWHTPADQTGHGSLNVAL---RKQLDIYANVALFKSLKGVKT-----RI 131 LK+ G P H SL +L R++ D Y N+ + GV ++ Sbjct: 66 QLKQYDAIYFGAVGWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALANRKV 125 Query: 132 PDIDLIVIRENTEGEFSGL--------EHESVPGVVESLKVMTRPKTERIARFAFDFAKK 183 DID +V+RENTEGE+S L E+E V + ES + TR +RI ++AFD A+K Sbjct: 126 GDIDFVVVRENTEGEYSSLGGIMFENTENEIV--IQES--IFTRRGVDRILKYAFDLAEK 181 Query: 184 YNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDV 243 RK VT+ K+N M + + + TE YP + +D + V +P +FDV Sbjct: 182 RERKHVTSATKSNGMAIS-MPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDV 240 Query: 244 LVTPSMYGTILGNIGAALIGGPGLVAGANFG--RDY-AVFEP--GSRHVGLDIKGQNVAN 298 +V +++G IL ++G A G G+ AN R++ ++FEP GS DI G+N+AN Sbjct: 241 VVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGS---APDIFGKNIAN 297 Query: 299 PTAMILSSTLMLNHLGL-NEYATR----ISKAVHETIAEGKHTTRDIGGSSSTTDFTNEI 353 P AMI S LML LG +E R + A+ IA+G T D+GG+ ST I Sbjct: 298 PIAMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVIADGS-VTPDMGGTLSTQQVGAAI 356 Query: 354 INKLSTM 360 + L+ + Sbjct: 357 SDTLARL 363 >1A05-A nrPDB Length = 358 Score = 133 bits (335), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 108/341 (31%), Positives = 169/341 (49%), Gaps = 47/341 (13%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAENIPIDWET-INIKQTDHKEG---------------- 73 + + GDG+G EI + R + +A +D + ++ T+ G Sbjct: 4 IAIFAGDGIGPEIVAAARQVLDA----VDQAAHLGLRCTEGLVGGAALDASDDPLPAASL 59 Query: 74 -VYEAVESLKRNKIGLKGLW--HTPADQTGHGSLNVALRKQLDIYANV---ALFKSLKGV 127 + A +++ +G W + PA + G L LRK LD+YAN+ +F L Sbjct: 60 QLAMAADAVILGAVG-GPRWDAYPPAKRPEQGLLR--LRKGLDLYANLRPAQIFPQLLDA 116 Query: 128 KTRIP----DIDLIVIRENTEGEFSGLEH--ESVPGVVESLKVMTRPKTE--RIARFAFD 179 P D+D++V+RE T + G E + G M + E RIA AF Sbjct: 117 SPLRPELVRDVDILVVRELTGDIYFGQPRGLEVIDGKRRGFNTMVYDEDEIRRIAHVAFR 176 Query: 180 FAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPH 239 A+ RK + +V KAN+++ L+R ++TE+ ++YPD+ +S + VDNA+MQ + P Sbjct: 177 AAQG-RRKQLCSVDKANVLETTR-LWREVVTEVA-RDYPDVRLSHMYVDNAAMQLIRAPA 233 Query: 240 QFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEP--GSRHVGLDIKGQNVA 297 QFDVL+T +M+G IL + + L G G++ A+ G A++EP GS DI GQ+ A Sbjct: 234 QFDVLLTGNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGS---APDIAGQDKA 290 Query: 298 NPTAMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTT 337 NP A ILS +ML H L +A R+ AV + +G T Sbjct: 291 NPLATILSVAMMLRHSLNAEPWAQRVEAAVQRVLDQGLRTA 331 >5M2E-A nrPDB Length = 418 Score = 129 bits (323), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 109/396 (27%), Positives = 186/396 (46%), Gaps = 77/396 (19%) Query: 31 VTLIPGDGVGKEITD--------SVRTIFEAENIPIDWETINIKQTDHKEGVY------- 75 + I GDG+G +I+ +V ++ E I W + + + VY Sbjct: 31 IPFIEGDGIGVDISPVMIKVVDAAVEKAYKGER-KIAW--MEVYAGEKATQVYDQDTWLP 87 Query: 76 -EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 E +++++ + +KG TP G SLNVALR+QLD+Y + +GV + + Sbjct: 88 QETLDAVRDYVVSIKGPLTTPVG-GGIRSLNVALRQQLDLYVCQRPVRWFEGVPSPVKKP 146 Query: 133 -DIDLIVIRENTEGEFSGLEHESVPGVVESLKVM-------------------------T 166 D+D+++ REN+E ++G+E ++ G E+ KV+ + Sbjct: 147 GDVDMVIFRENSEDIYAGVEWKA--GSPEAEKVIKFLTEEMGVKKIRFTENCGIGIKPVS 204 Query: 167 RPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY--------- 217 + T+R+ R A +A +R SVT VHK NIMK +G F++ E+ + E+ Sbjct: 205 QEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAELLDGGP 264 Query: 218 ----------PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGL 267 ++ V +I D Q + +P ++DV+ T ++ G L + AA +GG G+ Sbjct: 265 WMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEVGGIGI 324 Query: 268 VAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVH 327 GAN A+FE + GQ+ NP ++ILS+ +ML H+G E A I K + Sbjct: 325 APGANLSDSVAMFE-ATHGTAPKYAGQDKVNPGSLILSAEMMLRHMGWTEAADLIIKGTN 383 Query: 328 ETIAEGKHTTRD----IGGSS--STTDFTNEIINKL 357 IA K T D + G++ S ++F + +I K+ Sbjct: 384 GAIA-AKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >3DMS-A nrPDB Length = 427 Score = 128 bits (321), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 111/370 (30%), Positives = 171/370 (46%), Gaps = 65/370 (17%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTDHKEGVY-------- 75 + I GDG G +IT + + +A I W I + K VY Sbjct: 39 IPYIEGDGTGFDITPVMIKVVDAAVEKAYGGKKKIHWMEIYAGEKATK--VYGPDVWLPE 96 Query: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKT--RIPD 133 E ++ LK + +KG TP G SLNVALR++LD+Y + + KGV + R P+ Sbjct: 97 ETLQVLKEYVVSIKGPLTTPVG-GGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVREPE 155 Query: 134 -IDLIVIRENTEGEFSGLE----HESVPGVVESL-------------------KVMTRPK 169 ++++ REN+E ++G+E E V++ L K +++ Sbjct: 156 KTNMVIFRENSEDIYAGIEWAAESEQAKKVIKFLQEEMGVKKIRFPQTSGIGIKPVSKEG 215 Query: 170 TERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY------------ 217 TER+ R A +A +RKSVT VHK NIMK +G FR+ + QKE+ Sbjct: 216 TERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTEGAFRDAGYALAQKEFGAELIDGGPWMK 275 Query: 218 -------PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAG 270 +I V I D Q + +P ++DV+ T ++ G + + AA +GG G+ G Sbjct: 276 FKNPKTGNEIVVKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGGIGIAPG 335 Query: 271 ANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETI 330 AN A+FE + G++ NP + ILS+ +ML HLG E A I A+ ++I Sbjct: 336 ANLSDSVAMFE-ATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADVIISAMEKSI 394 Query: 331 AEGKHTTRDI 340 + K T D Sbjct: 395 KQ-KRVTYDF 403 >3VMK-A nrPDB Length = 375 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 101/347 (29%), Positives = 175/347 (50%), Gaps = 52/347 (14%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGV-------------- 74 + + ++ GDG+G E+ R + A D ++I+ +++ G Sbjct: 14 YQIAVLAGDGIGPEVMAEARKVLAAVEKRFD---LSIEYSEYDVGGAAIDNHGCPLPEAT 70 Query: 75 ---YEAVESLKRNKIGLKGLWHTPA-DQTGHGSLNVALRKQLDIYANVALFKSLKGVKTR 130 EA +++ +G H P DQ G+L + LR +++ N+ K G++ Sbjct: 71 LKGCEAADAVLFGSVGGPKWEHLPPNDQPERGAL-LPLRGHFELFCNMRPAKLHPGLEHM 129 Query: 131 IP---DI-----DLIVIRENTEGEFSGL--------EHESVPGVVESLKVM--TRPKTER 172 P DI D++ +RE T G + G E+E E+ M +R + R Sbjct: 130 SPLRSDISEKGFDILCVRELTGGIYFGKPKGRQGEGENE------EAFDTMRYSRKEIRR 183 Query: 173 IARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASM 232 IA+ AF+ A+ RK VT+V KAN++ L+R ++ E+ K+YPD+++ I +DNA+M Sbjct: 184 IAKIAFESAQG-RRKKVTSVDKANVLAC-SVLWREVVEEVA-KDYPDVELEHIYIDNATM 240 Query: 233 QAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANF-GRDYAVFEPGSRHVGLDI 291 Q + +P++FDV++ +++G I+ + A L G GL+A + + + ++EP DI Sbjct: 241 QLLRRPNEFDVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQGFGMYEPAGGSAP-DI 299 Query: 292 KGQNVANPTAMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTT 337 GQ +ANP A ILS+ L+L H L L + A I AV + +++G T Sbjct: 300 AGQGIANPVAQILSAALLLRHSLKLEDAALAIEAAVSKALSDGYLTC 346 >2G4O-A nrPDB Length = 337 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 104/332 (31%), Positives = 172/332 (51%), Gaps = 26/332 (7%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAENIPIDWETINI-KQTDHKEGVY---EAVESLKRNKI 86 + +I GDG+G E+T + +A + + ++ + H G V L+ + Sbjct: 4 LAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDA 63 Query: 87 GLKGLWHTPADQTG--HGSLNVALRKQLDIYANVALFKSLKGVKTRI---PDIDLIVIRE 141 L G P+ +G L + LR +LD + N+ + GV + + P ID +V+RE Sbjct: 64 ILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVRE 123 Query: 142 NTEGEFSG----LEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANI 197 TEG ++G + + V + V T R+ AF+ A++ RK +T VHK N+ Sbjct: 124 GTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARR-RRKHLTLVHKTNV 182 Query: 198 MKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNI 257 + GL+ + E+G+ YPD++V+ VD A++ + P +FDV+VT +++G I+ ++ Sbjct: 183 LTFAGGLWLRTVDEVGEC-YPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDL 241 Query: 258 GAALIGGPGLVAGANFGRDYA---VFEP--GSRHVGLDIKGQNVANPTAMILSSTLMLNH 312 AA+ GG GL A N A +FEP GS DI GQ +A+PTA I+S L+L+H Sbjct: 242 AAAVCGGIGLAASGNIDATRANPSMFEPVHGS---APDIAGQGIADPTAAIMSVALLLSH 298 Query: 313 LGLNEYATRISKAVHETIA---EGKHTTRDIG 341 LG ++ A R+ +AV +A + T D+G Sbjct: 299 LGEHDAAARVDRAVEAHLATRGSERLATSDVG 330 >3VML-A nrPDB Length = 375 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 102/346 (29%), Positives = 173/346 (50%), Gaps = 52/346 (15%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGV-------------- 74 + + ++ GDG+G E+ R + +A +NI+ T++ G Sbjct: 14 YQIAVLAGDGIGPEVMAEARKVLKAVEARF---GLNIEYTEYDVGGIAIDNHGCPLPEAT 70 Query: 75 ---YEAVESLKRNKIGLKGLWHTPA-DQTGHGSLNVALRKQLDIYANVALFKSLKGVKTR 130 EA +++ +G H P DQ G+L + LR +++ N+ K G++ Sbjct: 71 LKGCEAADAVLFGSVGGPKWEHLPPNDQPERGAL-LPLRGHFELFCNMRPAKLHPGLEHM 129 Query: 131 IP---DI-----DLIVIRENTEGEFSGL--------EHESVPGVVESLKVM--TRPKTER 172 P DI D++ +RE T G + G E+E E+ M +R + R Sbjct: 130 SPLRSDISEKGFDILCVRELTGGIYFGKPKGRQGEGENE------EAFDTMRYSRKEIRR 183 Query: 173 IARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASM 232 IA+ AF+ A+ RK VT+V KAN++ L+R ++ E+ K+YPD+++ I +DNA+M Sbjct: 184 IAKIAFESAQG-RRKKVTSVDKANVLAC-SVLWREVVEEVA-KDYPDVELEHIYIDNATM 240 Query: 233 QAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANF-GRDYAVFEPGSRHVGLDI 291 Q + +P++FDV++ +++G I+ + A L G GL+A + + + ++EP DI Sbjct: 241 QLLRRPNEFDVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQGFGMYEPAGGSAP-DI 299 Query: 292 KGQNVANPTAMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHT 336 GQ +ANP A ILS+ L+L H L L + A I AV + + G T Sbjct: 300 AGQGIANPVAQILSAALLLRHSLKLEDAALAIEAAVSKALNSGYLT 345 >1XGV-A nrPDB Length = 435 Score = 125 bits (314), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 103/366 (28%), Positives = 173/366 (47%), Gaps = 59/366 (16%) Query: 30 TVTLIPGDGVGKEITDS--------VRTIFEAENIPIDWETINIKQTDHKEGVY---EAV 78 V I GDGVG E+ +S V+ ++ + WE + K G + Sbjct: 37 VVAFIRGDGVGPEVVESALKVVDAAVKKVYGGSRRIVWWELLAGHLAREKCGELLPKATL 96 Query: 79 ESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSL-KGVKTRIPD-IDL 136 E ++ ++ LKG TP TG+ SLNVA+R+ LD+YAN+ + + + D +D+ Sbjct: 97 EGIRLARVALKGPLETPVG-TGYRSLNVAIRQALDLYANIRPVRYYGQPAPHKYADRVDM 155 Query: 137 IVIRENTEGEFSGLE--HESVPGVVE-------------------SLKVMTRPKTERIAR 175 ++ RENTE ++G+E H+S P +K ++R T R+ Sbjct: 156 VIFRENTEDVYAGIEWPHDS-PEAARIRRFLAEEFGISIREDAGIGVKPISRFATRRLME 214 Query: 176 FAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIG--------------QKEY---- 217 A ++A + VT +HK NIMK +G F E+ Q++Y Sbjct: 215 RALEWALRNGNTVVTIMHKGNIMKYTEGAFMRWAYEVALEKFREHVVTEQEVQEKYGGVR 274 Query: 218 PD--IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGR 275 P+ I V+ I DN Q + +P + V+V P++ G + + +AL+GG G+ AG N G Sbjct: 275 PEGKILVNDRIADNMLQQIITRPWDYQVIVAPNLNGDYISDAASALVGGIGMAAGMNMGD 334 Query: 276 DYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNH-LGLNEYATRISKAVHETIAEGK 334 AV EP G+++ NP+A ILS++L++ +G E + + A+ + + + K Sbjct: 335 GIAVAEP-VHGTAPKYAGKDLINPSAEILSASLLIGEFMGWREVKSIVEYAIRKAV-QSK 392 Query: 335 HTTRDI 340 T+D+ Sbjct: 393 KVTQDL 398 >1AI3-A nrPDB Length = 416 Score = 124 bits (311), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 94/358 (26%), Positives = 169/358 (47%), Gaps = 60/358 (16%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTD---HKEGVYEAVES 80 + I GDG+G ++T ++ + +A I W I + + + V+ E+ Sbjct: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 Query: 81 L---KRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI--PDI- 134 L + ++ +KG TP G SLNVALR++LD+Y + + +G + + P++ Sbjct: 89 LDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 Query: 135 DLIVIRENTEGEFSGLEHESVPGVVES-----------------------LKVMTRPKTE 171 D+++ REN+E ++G+E ++ E +K + T+ Sbjct: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 Query: 172 RIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY-------------- 217 R+ R A ++A +R SVT VHK NIMK +G F++ ++ ++E+ Sbjct: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 Query: 218 -----PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGAN 272 +I + +I D Q + +P ++DV+ ++ G + + AA +GG G+ GAN Sbjct: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 Query: 273 FGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETI 330 G + A+FE + GQ+ NP ++ILS+ +ML H+G E A I K + I Sbjct: 328 IGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI 384 >3VMJ-A nrPDB Length = 375 Score = 122 bits (306), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 103/345 (29%), Positives = 172/345 (49%), Gaps = 50/345 (14%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGV-------------- 74 + + ++ GDG+G E+ R + +A +NI+ T++ G Sbjct: 14 YQIAVLAGDGIGPEVMAEARKVLKAVEARF---GLNIEYTEYDVGGIAIDNHGCPLPEAT 70 Query: 75 ---YEAVESLKRNKIGLKGLWHT--PADQTGHGSLNVALRKQLDIYANVALFKSLKGVKT 129 EA +++ +G W P +Q G+L + LR +++ N+ K G++ Sbjct: 71 LKGCEAADAILFGSVG-GPKWEKLPPNEQPERGAL-LPLRGHFELFCNLRPAKLHDGLEH 128 Query: 130 RIP---DI-----DLIVIRENTEGEFSGL------EHESVPGVVESLKVM--TRPKTERI 173 P DI D++ +RE T G + G E ES E+ M +R + RI Sbjct: 129 MSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESE----EAFDTMRYSRREISRI 184 Query: 174 ARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQ 233 AR AF+ A + RK VT+V KAN++ L+R ++ E+ ++PD+++ I +DNA+MQ Sbjct: 185 ARIAFE-AARGRRKKVTSVDKANVLACSV-LWRQVVEEVAV-DFPDVELEHIYIDNATMQ 241 Query: 234 AVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGR-DYAVFEPGSRHVGLDIK 292 + +P +FDV++ +++G IL + A L G GL++ A+ + +FEP DI Sbjct: 242 LLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAP-DIA 300 Query: 293 GQNVANPTAMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHT 336 G+ +ANP A ILS+ LML H L E A+ I +AV + + G T Sbjct: 301 GKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLT 345 >6C0E-A nrPDB Length = 419 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 100/370 (27%), Positives = 169/370 (45%), Gaps = 65/370 (17%) Query: 31 VTLIPGDGVGKEITDSVRTIFEA-------ENIPIDWETINIKQTDHKEGVY-------- 75 + I GDG+G ++T + + +A I W + + K VY Sbjct: 32 IPFIEGDGIGVDVTPPMIRVVDAAVQKAYGNKRKISWMEVYAGEKATK--VYGGDQWLPK 89 Query: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPD-- 133 E ++++K+ + +KG TP G SLNVA+R+ +D+Y + + GV + + + Sbjct: 90 ETLDAMKKYVVSIKGPLTTPVG-GGIRSLNVAIRQDMDLYVCLRPIRYFNGVPSPVREPW 148 Query: 134 -IDLIVIRENTEGEFSGLEHES----VPGVVESL-------------------KVMTRPK 169 D+++ REN+E ++G+E ++ V++ L K ++R Sbjct: 149 KTDMVIFRENSEDIYAGIEWQADTPEAKKVIQFLTKEMGVKKIRFPEHCGIGVKPVSREG 208 Query: 170 TERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEI-----GQKEYP------ 218 T R+ + A +A +R +VT VHK NIMK +G F++ ++ G KEY Sbjct: 209 TTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTEGAFKDWGYQVARDSFGAKEYQGGPWME 268 Query: 219 --------DIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAG 270 I ++ +I D Q + +P + V+ T ++ G + + AA +GG G+ G Sbjct: 269 FKNPKTGKQIIINDVIADAFLQQILLRPEDYSVIATLNLNGDYISDALAAQVGGIGIAPG 328 Query: 271 ANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETI 330 AN AVFE + GQN NP ++ILS+ +ML H+G E A I + + I Sbjct: 329 ANISDQMAVFE-ATHGTAPKYAGQNKVNPGSIILSAEMMLRHMGWYEAADLIIRGMEGAI 387 Query: 331 AEGKHTTRDI 340 E K T D Sbjct: 388 -EAKTVTYDF 396 >5J32-A nrPDB Length = 403 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 102/341 (29%), Positives = 167/341 (48%), Gaps = 41/341 (12%) Query: 28 RFTVTLIPGDGVGKEITDSVRTI-----------FEAENIPIDWETINIKQTDHKEGVYE 76 R+T+TL+PGDG+G E+ + + F +PI +++ E E Sbjct: 40 RYTITLLPGDGIGPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPE---E 96 Query: 77 AVESLKRNKIGLKGL-----WHTPADQTGHGSLNVALRKQLDIYANVALFKSL------K 125 + + K + L G W + +R L ++AN+ L Sbjct: 97 TISAAKESDAVLLGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDAS 156 Query: 126 GVKTRIPD-IDLIVIRENTEGEFSGLE-----HESVPGVVESLKVMTRPKTERIARFAFD 179 +K + + +DL+V+RE T G + G +E+ V + +V + +RIAR AF+ Sbjct: 157 TLKREVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFE 216 Query: 180 FAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPH 239 A+K R + +V KAN+++ L+R +T + EYPD+++S + VDNA+MQ V P Sbjct: 217 TARK-RRGKLCSVDKANVLE-ASILWRKRVTALAS-EYPDVELSHMYVDNAAMQLVRDPK 273 Query: 240 QFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEP--GSRHVGLDIKGQNV 296 QFD +VT +++G IL + + + G G++ A+ +FEP GS DI GQ+ Sbjct: 274 QFDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAP---DIAGQDK 330 Query: 297 ANPTAMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHT 336 ANP A ILS+ ++L + LG + A RI AV + G T Sbjct: 331 ANPLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNGFRT 371 >4IWH-A nrPDB Length = 363 Score = 114 bits (285), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 96/338 (28%), Positives = 166/338 (49%), Gaps = 32/338 (9%) Query: 31 VTLIPGDGVGKEIT-DSVRTI------FEAENIPIDWETINIKQTDHKEGVYEAVESLKR 83 + ++PGDG+G EI ++V+ + FE E+ P+ + + Sbjct: 11 IAVLPGDGIGPEIVNEAVKVLNALDEKFELEHAPVGGAGYEASGHPLPDATLALAKEADA 70 Query: 84 NKIGLKGLWHTPADQTGHGSLN--VALRKQLDIYAN---VALFKSLKGVKTRIPDI---- 134 G G W + + + LRK L+++AN + L P++ Sbjct: 71 ILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASPLKPELVAGL 130 Query: 135 DLIVIRENTEGEFSGLEH--ESVP-----GVVESLKVM--TRPKTERIARFAFDFAKKYN 185 D++++RE + G + P G E M + P+ RIA AF A+K Sbjct: 131 DILIVRELNGDIYFGQPRGVRAAPDGPFAGEREGFDTMRYSEPEVRRIAHVAFQAAQKRA 190 Query: 186 RKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLV 245 +K + +V K+N+++ +R+++ ++ KEY D+++S + VDNA+MQ P QFDV+V Sbjct: 191 KK-LLSVDKSNVLETSQ-FWRDVMIDV-SKEYADVELSHMYVDNAAMQLAKAPKQFDVIV 247 Query: 246 TPSMYGTILGNIGAALIGGPGLVAGANFGR-DYAVFEPGSRHVGLDIKGQNVANPTAMIL 304 T +M+G IL + + L G G++ A+ + + ++EP S DI G+ +ANP A IL Sbjct: 248 TGNMFGDILSDEASMLTGSIGMLPSASLDKNNKGLYEP-SHGSAPDIAGKGIANPLATIL 306 Query: 305 SSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIG 341 S+ ++L + L E A RI +AV +T+ E + T DI Sbjct: 307 SAAMLLRYSLNRAEQADRIERAV-KTVLEQGYRTGDIA 343 >3UDO-A nrPDB Length = 361 Score = 103 bits (258), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 93/340 (27%), Positives = 167/340 (49%), Gaps = 30/340 (8%) Query: 29 FTVTLIPGDGVGKEITDSVRTI-----------FEAENIPIDWETIN---IKQTDHKEGV 74 + V ++ GDG+G + I FE I +I+ + +D + Sbjct: 7 YKVAVLAGDGIGPLVMKEALKILTFIAQKYNFSFELNEAKIGGASIDAYGVALSDETLKL 66 Query: 75 YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANV---ALFKSL---KGVK 128 E +++ +G + P DQ + + LRK +++AN+ +++SL +K Sbjct: 67 CEQSDAILFGSVGGPKWDNLPIDQRPERASLLPLRKHFNLFANLRPCKIYESLTHASPLK 126 Query: 129 TRI--PDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNR 186 I +D++ +RE T G + G + ++ ++ T+ + ERIAR AF+ A+ + Sbjct: 127 NEIIQKGVDILCVRELTGGIYFGKQDLGKESAYDT-EIYTKKEIERIARIAFESAR-IRK 184 Query: 187 KSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVT 246 K V + KAN++ L+R ++ + K+Y DI++ + VDNA+MQ V P FDV++ Sbjct: 185 KKVHLIDKANVLA-SSILWREVVANVA-KDYQDINLEYMYVDNAAMQIVKNPSIFDVMLC 242 Query: 247 PSMYGTILGNIGAAL-IGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILS 305 +++G IL + AA+ L + + + + ++EP DI N+ANP A ILS Sbjct: 243 SNLFGDILSDELAAINGSLGLLSSASLNDKGFGLYEPAGGSAP-DIAHLNIANPIAQILS 301 Query: 306 STLMLNHLGLNEYATR-ISKAVHETIAEGKHTTRDIGGSS 344 + LML + E A + I A+ +A+GK T+D+ S Sbjct: 302 AALMLKYSFKEEQAAQDIENAISLALAQGK-MTKDLNAKS 340 >5I96-A nrPDB Length = 458 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 83/215 (38%), Gaps = 38/215 (17%) Query: 176 FAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYP-DIDVSSI-----IVDN 229 F + KK+ T K I+K DG F++I EI K Y D D + I ++D+ Sbjct: 236 FQYAIQKKWPLYMST---KNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDD 292 Query: 230 ASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPG------ 283 Q + F V + G + +I A G GL+ D E Sbjct: 293 MVAQVLKSSGGF-VWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTV 351 Query: 284 SRHVGLDIKGQNVA-NPTAMILSSTLMLNHLG-------LNEYATRISKAVHETIAEGKH 335 +RH KG+ + NP A I + T L H G L +A + K ET+ G Sbjct: 352 TRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGA- 410 Query: 336 TTRDIGGS-------------SSTTDFTNEIINKL 357 T+D+ G +TTDF + I + L Sbjct: 411 MTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNL 445 >1E5F-A nrPDB Length = 404 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 36/137 (26%), Positives = 61/137 (44%), Gaps = 13/137 (9%) Query: 41 KEITDSVRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPADQTG 100 K+IT SV + +A I T+NI+ E + E LK + K + D G Sbjct: 238 KDITGSVISPHDAWLITRGLSTLNIRMKAESENAMKVAEYLKSHPAVEKVYYPGFEDHEG 297 Query: 101 HGSLNVALRKQLDIYANVALF---KSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPG 157 H ++A +KQ+ +Y ++ F +G K + ++ LI + + G S ++H + Sbjct: 298 H---DIA-KKQMRMYGSMITFILKSGFEGAKKLLDNLKLITLAVSLGGCESLIQHPA--- 350 Query: 158 VVESLKVMTRPKTERIA 174 S+ PK ER A Sbjct: 351 ---SMTHAVVPKEEREA 364 >6BL1-B nrPDB Length = 425 Score = 31.6 bits (70), Expect = 0.54, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 74/192 (38%), Gaps = 30/192 (15%) Query: 194 KANIMKLGDGLFRNIITEIGQKEYPD------IDVSSIIVDNASMQAVAKPHQFDVLVTP 247 K I+K DG F++I EI K+Y I ++D+ QA+ F + Sbjct: 212 KNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGF-IWACK 270 Query: 248 SMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPG------SRHVGLDIKGQNVA-NPT 300 + G + + A G G++ D E +RH + KGQ + NP Sbjct: 271 NYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPI 330 Query: 301 AMILSSTLMLNHLG-------LNEYATRISKAVHETIAEGKHTTRDIGGS------SSTT 347 A I + T L H L +A + + ETI G T+D+ + Sbjct: 331 ASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAG-FMTKDLAACIKGLPNVQRS 389 Query: 348 DFTN--EIINKL 357 D+ N E ++KL Sbjct: 390 DYLNTFEFMDKL 401 >3E15-A nrPDB Length = 312 Score = 31.2 bits (69), Expect = 0.80, Method: Compositional matrix adjust. Identities = 37/136 (27%), Positives = 60/136 (44%), Gaps = 19/136 (13%) Query: 112 LDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKV-----MT 166 +D+Y N+AL K +K +++ I I+ + + ++ + ESLK+ + Sbjct: 73 IDVYKNIALVKDIKIDTSKL--IFFIIDERYKRDDHKFSNYNNIKFLFESLKINEKEQLY 130 Query: 167 RPKTER-IARFAFDFAKKYNRKSVTAVHKANIMKLGDG-------LFRNIITEIGQKEYP 218 RP T + I D+ +K + V K +I LG G LF NI I Y Sbjct: 131 RPDTSKNIVECVRDYNEKI-KNMVKKYTKVDIAILGMGSDFHIASLFPNIFFNIYMNNYQ 189 Query: 219 D---IDVSSIIVDNAS 231 + D SSI V N++ Sbjct: 190 NSYIYDESSIKVANSN 205 >3AZC-A nrPDB Length = 133 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 24/86 (27%), Positives = 35/86 (40%), Gaps = 10/86 (11%) Query: 268 VAGANFGRDYAVFE------PGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATR 321 VA G D V E PG R + IKG +PT +I++ + + GLN T Sbjct: 8 VAKDALGNDIKVSEYLAKHLPGDRSLAQGIKG----DPTYVIVTEDHQIANYGLNAVCTH 63 Query: 322 ISKAVHETIAEGKHTTRDIGGSSSTT 347 + V ++E K G +T Sbjct: 64 LGCVVPWNVSENKFICPCHGSQYDST 89 >3S47-A nrPDB Length = 401 Score = 27.7 bits (60), Expect = 8.8, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 58/129 (44%), Gaps = 18/129 (13%) Query: 23 KKYGGRFTVTLIPGD-----GVGKEITDSVRTIFEAENIPIDWET-INIKQTD----HKE 72 +KY F ++P D G + T + E N P++W++ I +Q D H Sbjct: 225 EKYKPYFIEDILPPDQNEWLGQIRSQTSTPLATGELFNNPMEWKSLIANRQVDFIRCHVS 284 Query: 73 GVYEAVESLKRNKI----GLKGLWHTPADQTGHG-SLNVALRKQLD---IYANVALFKSL 124 + +LK + G++ WHTP+D T G ++N+ L L I N+ + + Sbjct: 285 QIGGITPALKLGSLCAAFGVRIAWHTPSDITPIGVAVNIHLNINLHNAAIQENIEINDNT 344 Query: 125 KGVKTRIPD 133 + V + IP+ Sbjct: 345 RCVFSGIPE 353 >3HR8-A nrPDB Length = 356 Score = 27.7 bits (60), Expect = 9.1, Method: Compositional matrix adjust. Identities = 12/34 (35%), Positives = 21/34 (61%) Query: 53 AENIPIDWETINIKQTDHKEGVYEAVESLKRNKI 86 A+N+ +D +++ I Q DH E E V+ L R+ + Sbjct: 106 AKNLGVDLKSLLISQPDHGEQALEIVDELVRSGV 139 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3BLX-A nrPDB 491 e-139 5YVT-A nrPDB 431 e-121 5GRH-B nrPDB 422 e-119 3BLV-B nrPDB 411 e-115 2D1C-A nrPDB 398 e-111 2IV0-A nrPDB 374 e-104 1AI3-A nrPDB 372 e-103 3ASJ-A nrPDB 368 e-102 5M2E-A nrPDB 368 e-102 1HQS-A nrPDB 360 e-100 6C0E-A nrPDB 360 e-100 2E5M-A nrPDB 360 e-100 3DMS-A nrPDB 358 2e-99 2D4V-A nrPDB 356 7e-99 1CM7-A nrPDB 355 1e-98 1XAD-A nrPDB 353 6e-98 1CNZ-A nrPDB 352 2e-97 4Y1P-A nrPDB 346 7e-96 3U1H-A nrPDB 345 1e-95 1WPW-A nrPDB 345 2e-95 1IDM-A nrPDB 344 3e-95 3VMK-A nrPDB 344 4e-95 3VMJ-A nrPDB 343 7e-95 1VLC-A nrPDB 342 1e-94 3VML-A nrPDB 342 2e-94 3TY3-A nrPDB 341 2e-94 3FMX-X nrPDB 340 5e-94 5HN5-A nrPDB 338 3e-93 1V5B-A nrPDB 333 1e-91 1XGV-A nrPDB 332 2e-91 3UDO-A nrPDB 321 3e-88 1A05-A nrPDB 318 2e-87 5J32-A nrPDB 313 8e-86 4IWH-A nrPDB 305 1e-83 2G4O-A nrPDB 289 1e-78 5I96-A nrPDB 157 8e-39 Sequences not found previously or not previously below threshold: 2QFY-A nrPDB 132 3e-31 6BL1-B nrPDB 126 2e-29 4HCX-A nrPDB 120 1e-27 3US8-A nrPDB 119 2e-27 1ZOR-A nrPDB 115 3e-26 4AOY-A nrPDB 112 3e-25 2UXQ-A nrPDB 94 1e-19 5Z16-A nrPDB 35 0.047 1J1W-A nrPDB 34 0.13 5CQS-A nrPDB 33 0.16 4A8J-A nrPDB 33 0.27 4ZDA-A nrPDB 31 0.58 5KVU-A nrPDB 31 0.74 6H3G-A nrPDB 31 0.85 6G3U-A nrPDB 31 0.95 1YE8-A nrPDB 31 0.95 4JQP-A nrPDB 31 1.1 6EJB-A nrPDB 30 2.0 1NRX-A nrPDB 30 2.1 2B0T-A nrPDB 30 2.1 3RUY-A nrPDB 30 2.5 1TXG-A nrPDB 29 2.8 1D5A-A nrPDB 29 3.8 1F1E-A nrPDB 29 4.1 5B63-A nrPDB 29 4.2 6GIQ-A nrPDB 28 5.2 2XV4-S nrPDB 28 5.6 4V7E-BD nrPDB 27 9.8 >3BLX-A nrPDB Length = 349 Score = 491 bits (1265), Expect = e-139, Method: Composition-based stats. Identities = 349/349 (100%), Positives = 349/349 (100%) Query: 12 ATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHK 71 ATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHK Sbjct: 1 ATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHK 60 Query: 72 EGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI 131 EGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI Sbjct: 61 EGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI 120 Query: 132 PDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTA 191 PDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTA Sbjct: 121 PDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTA 180 Query: 192 VHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYG 251 VHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYG Sbjct: 181 VHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYG 240 Query: 252 TILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLN 311 TILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLN Sbjct: 241 TILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLN 300 Query: 312 HLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 360 HLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM Sbjct: 301 HLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 349 >5YVT-A nrPDB Length = 339 Score = 431 bits (1109), Expect = e-121, Method: Composition-based stats. Identities = 154/340 (45%), Positives = 218/340 (64%), Gaps = 8/340 (2%) Query: 26 GGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVY----EAVESL 81 GG TVTLIPGDG+G EI+ +V IF+A PI WE N+ G + EA ES+ Sbjct: 2 GGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESM 61 Query: 82 KRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRE 141 +NK+GLKG TP GH S+N+ LRK D+YANV S++G KT D++++ IRE Sbjct: 62 DKNKMGLKGPLKTPI-AAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRE 120 Query: 142 NTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLG 201 NTEGE+SG+EH V GVV+S+K++T ++RIA FAF++A+ +R +VTAVHKANIM++ Sbjct: 121 NTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMS 180 Query: 202 DGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAAL 261 DGLF E+ + DI + + +D + V P QFDVLV P++YG IL ++ A L Sbjct: 181 DGLFLQKCREVAE-SCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGL 239 Query: 262 IGGPGLVAGANFG-RDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYAT 320 IGG G+ N G A+FE DI G+++ANPTA++LS+ +ML H+GL ++A Sbjct: 240 IGGLGVTPSGNIGANGVAIFE-SVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAA 298 Query: 321 RISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 360 RI A TI +GK T+D+GG++ +DFT EI ++ + Sbjct: 299 RIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDL 338 >5GRH-B nrPDB Length = 354 Score = 422 bits (1086), Expect = e-119, Method: Composition-based stats. Identities = 170/347 (48%), Positives = 239/347 (68%), Gaps = 4/347 (1%) Query: 17 AERTLP--KKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGV 74 +E+T+P KYGGR TVT+IPGDG+G E+ V+++F +P+D+E +++ +E + Sbjct: 2 SEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDI 61 Query: 75 YEAVESLKRNKIGLKGLWHTPADQTG-HGSLNVALRKQLDIYANVALFKSLKGVKTRIPD 133 A+ +++RN++ LKG T + H S N LR LD+YANV KSL GV TR D Sbjct: 62 RNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKD 121 Query: 134 IDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVH 193 ID++++RENTEGE+S LEHESV GVVESLK++T+ K+ RIA +AF A++ RK VTAVH Sbjct: 122 IDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVH 181 Query: 194 KANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTI 253 KANIMKLGDGLF E+ + YP I ++IVDN +MQ V++P QFDV+V P++YG I Sbjct: 182 KANIMKLGDGLFLQCCREVAAR-YPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNI 240 Query: 254 LGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHL 313 + N+ A L+GGPGLVAGAN+G YAVFE +R+ G I +N+ANPTA +L+S +ML+HL Sbjct: 241 VNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHL 300 Query: 314 GLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 360 L+ YAT I KAV ++ T DIGG +T++ ++I + + Sbjct: 301 KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIRVI 347 >3BLV-B nrPDB Length = 354 Score = 411 bits (1057), Expect = e-115, Method: Composition-based stats. Identities = 146/343 (42%), Positives = 219/343 (63%), Gaps = 10/343 (2%) Query: 22 PKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTD---HKEGVYEAV 78 P G++TV+ I GDG+G EI+ SV+ IF A N+PI+WE+ ++ AV Sbjct: 15 PNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAV 74 Query: 79 ESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIV 138 +S+ +N + LKG TP + GH SLN+ LRK ++ANV KS++G KT ++DL++ Sbjct: 75 QSITKNLVALKGPLATPIGK-GHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVL 133 Query: 139 IRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIM 198 IRENTEGE+SG+EH PGVV+S+K++TR +ER+ R+AF++A+ R V VHK+ I Sbjct: 134 IRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQ 193 Query: 199 KLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD--VLVTPSMYGTILGN 256 +L DGLF N+ E+ KEYPD+ + + ++DN+ ++ V P + V V P++YG IL + Sbjct: 194 RLADGLFVNVAKEL-SKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSD 252 Query: 257 IGAAL-IGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGL 315 + + L G GL AN G ++FE DI GQ+ ANPTA++LSS +MLNH+GL Sbjct: 253 LNSGLSAGSLGLTPSANIGHKISIFE-AVHGSAPDIAGQDKANPTALLLSSVMMLNHMGL 311 Query: 316 NEYATRISKAVHETIAEG-KHTTRDIGGSSSTTDFTNEIINKL 357 +A +I AV TIA G ++ T D+ G+++T+ FT +I +L Sbjct: 312 TNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL 354 >2D1C-A nrPDB Length = 496 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 130/341 (38%), Positives = 191/341 (56%), Gaps = 13/341 (3%) Query: 27 GRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEG-----VYEAVESL 81 GR +T+IPGDG+G E ++ + EA P+ +E + + G E +ES+ Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESI 77 Query: 82 KRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPD--IDLIVI 139 ++ ++ LKG TP G S NV LRK + YANV + V T IDL+V+ Sbjct: 78 RKTRVVLKGPLETPVGY-GEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVV 136 Query: 140 RENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMK 199 REN E ++G+EH P V ++LK+++ +E+I RFAF+ A+ RK V K+NIMK Sbjct: 137 RENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMK 196 Query: 200 LGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGA 259 L +G + ++ Q EYPDI+ IIVDNA+ Q V +P QF+V+VT +M G IL ++ + Sbjct: 197 LAEGTLKRAFEQVAQ-EYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTS 255 Query: 260 ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYA 319 LIGG G AN G + A+FE G+NV NPTA++LS+ +ML +L A Sbjct: 256 GLIGGLGFAPSANIGNEVAIFE-AVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFATA 314 Query: 320 TRISKAVHETIAEGKHTTRDIGG---SSSTTDFTNEIINKL 357 I A+ T+ EG+ T D+ G + TT++T II L Sbjct: 315 DLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNL 355 >2IV0-A nrPDB Length = 412 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 114/385 (29%), Positives = 179/385 (46%), Gaps = 57/385 (14%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAENIPID----WETINIKQTDHKEG----VYEAVESLK 82 + GDG+GK++ + + +A I W + + +K + + ++K Sbjct: 30 IPYFEGDGIGKDVVPAAIRVLDAAADKIGKEVVWFQVYAGEDAYKLYGNYLPDDTLNAIK 89 Query: 83 RNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI---PDIDLIVI 139 ++ LKG TP G+ SLNV +R+ LD+YANV LKGV + I ++ ++ Sbjct: 90 EFRVALKGPLTTPVG-GGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKVNFVIF 148 Query: 140 RENTEGEFSGLEHESVPGVV--------------------ESLKVMTRPKTERIARFAFD 179 RENTE ++G+E +K ++ T+R+ R A Sbjct: 149 RENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFATKRLVRMAIR 208 Query: 180 FAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD-------------------- 219 +A + NRKSVT VHK NIMK +G FR+ E+ ++E+ + Sbjct: 209 YAIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQEFGEYCITEDELWDKYGGKQPEGK 268 Query: 220 IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAV 279 I V I DN Q + + ++DV+ P++ G L + AALIGG G+ G+N G V Sbjct: 269 IVVKDRIADNMFQQILTRTDEYDVIALPNLNGDYLSDAAAALIGGLGIAPGSNIGDGIGV 328 Query: 280 FEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTT-- 337 FEP GQN NPTA IL+ LM ++G + + I KAV TI+ G T Sbjct: 329 FEP-VHGSAPKYAGQNKVNPTAEILTGALMFEYIGWKDASEMIKKAVEMTISSGIVTYDI 387 Query: 338 -RDIGGS-SSTTDFTNEIINKLSTM 360 R +GG+ T +F ++ L ++ Sbjct: 388 HRHMGGTKVGTREFAEAVVENLQSL 412 >1AI3-A nrPDB Length = 416 Score = 372 bits (955), Expect = e-103, Method: Composition-based stats. Identities = 98/391 (25%), Positives = 177/391 (45%), Gaps = 67/391 (17%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTD---HKEGVY---EA 77 + I GDG+G ++T ++ + +A I W I + + + V+ E Sbjct: 29 IPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAET 88 Query: 78 VESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPD---I 134 ++ ++ ++ +KG TP G SLNVALR++LD+Y + + +G + + Sbjct: 89 LDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 147 Query: 135 DLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLKVMTRPKTE 171 D+++ REN+E ++G+E ++ E +K + T+ Sbjct: 148 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 207 Query: 172 RIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY-------------- 217 R+ R A ++A +R SVT VHK NIMK +G F++ ++ ++E+ Sbjct: 208 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVK 267 Query: 218 -----PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGAN 272 +I + +I D Q + +P ++DV+ ++ G + + AA +GG G+ GAN Sbjct: 268 NPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGAN 327 Query: 273 FGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAE 332 G + A+FE + GQ+ NP ++ILS+ +ML H+G E A I K + I Sbjct: 328 IGDECALFE-ATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAI-N 385 Query: 333 GKHTTRDI------GGSSSTTDFTNEIINKL 357 K T D ++F + II + Sbjct: 386 AKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416 >3ASJ-A nrPDB Length = 334 Score = 368 bits (946), Expect = e-102, Method: Composition-based stats. Identities = 121/337 (35%), Positives = 186/337 (55%), Gaps = 10/337 (2%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIK----QTDHKEGVYEAVESLKRN 84 + + LI GDG+G E+ + R + EA +P+++ + E VE + Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEATGLPLEFVEAEAGWETFERRGTSVPEETVEKILSC 62 Query: 85 KIGLKGLWHTPADQ-TGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENT 143 L G +P + G LR++LD+YANV KS + V P +DL+++RENT Sbjct: 63 HATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKS-RPVPGSRPGVDLVIVRENT 121 Query: 144 EGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDG 203 EG + E + V + V+++ +ERI R A A+ RK++ HKAN++ L G Sbjct: 122 EGLYVEQERRYLD-VAIADAVISKKASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQG 180 Query: 204 LFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIG 263 LF + + E+ K++P ++V IIVDN +MQ V +P +FDV+VT ++ G IL ++ A L+G Sbjct: 181 LFLDTVKEVA-KDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVG 239 Query: 264 GPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRIS 323 G GL N G AVFEP DI G+ +ANPTA ILS+ +ML++LG E A R+ Sbjct: 240 GLGLAPSGNIGDTTAVFEP-VHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVE 298 Query: 324 KAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 360 KAV + G T D+GG ++T FT ++ L ++ Sbjct: 299 KAVDLVLERGPR-TPDLGGDATTEAFTEAVVEALKSL 334 >5M2E-A nrPDB Length = 418 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 104/391 (26%), Positives = 179/391 (45%), Gaps = 67/391 (17%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTDH------KEGVYEA 77 + I GDG+G +I+ + + +A I W + + E Sbjct: 31 IPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTWLPQET 90 Query: 78 VESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP---DI 134 +++++ + +KG TP G SLNVALR+QLD+Y + +GV + + D+ Sbjct: 91 LDAVRDYVVSIKGPLTTPVG-GGIRSLNVALRQQLDLYVCQRPVRWFEGVPSPVKKPGDV 149 Query: 135 DLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLKVMTRPKTE 171 D+++ REN+E ++G+E ++ E +K +++ T+ Sbjct: 150 DMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIGIKPVSQEGTK 209 Query: 172 RIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY-------------- 217 R+ R A +A +R SVT VHK NIMK +G F++ E+ + E+ Sbjct: 210 RLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAELLDGGPWMQFK 269 Query: 218 -----PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGAN 272 ++ V +I D Q + +P ++DV+ T ++ G L + AA +GG G+ GAN Sbjct: 270 NPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEVGGIGIAPGAN 329 Query: 273 FGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAE 332 A+FE + GQ+ NP ++ILS+ +ML H+G E A I K + IA Sbjct: 330 LSDSVAMFE-ATHGTAPKYAGQDKVNPGSLILSAEMMLRHMGWTEAADLIIKGTNGAIA- 387 Query: 333 GKHTTRD----IGGS--SSTTDFTNEIINKL 357 K T D + G+ S ++F + +I K+ Sbjct: 388 AKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >1HQS-A nrPDB Length = 423 Score = 360 bits (924), Expect = e-100, Method: Composition-based stats. Identities = 113/405 (27%), Positives = 186/405 (45%), Gaps = 80/405 (19%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTDH-KEGVY---EAVE 79 + I GDG G +I ++ + EA I W+ + + + K G + E ++ Sbjct: 22 IPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLD 81 Query: 80 SLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI---PDIDL 136 ++ I +KG TP G SLNVALR++LD++ + + GV + + D D+ Sbjct: 82 VIREYFIAIKGPLTTPVG-GGIRSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDM 140 Query: 137 IVIRENTEGEFSGLEHESVPGVVE-----------------------SLKVMTRPKTERI 173 ++ RENTE ++G+E+ V+ +K ++ T R+ Sbjct: 141 VIFRENTEDIYAGIEYAKGSEEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRL 200 Query: 174 ARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD-------------- 219 R A D+A ++ RKSVT VHK NIMK +G F+N E+ +KEY D Sbjct: 201 VRAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEE 260 Query: 220 ------------------IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAAL 261 I + I D Q + +P++FDV+ T ++ G + + AA Sbjct: 261 QGKDAANKAQSEAEAAGKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQ 320 Query: 262 IGGPGLVAGANFGR--DYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYA 319 +GG G+ GAN +A+FE + G + NP+++ILS L+L HLG NE A Sbjct: 321 VGGIGIAPGANINYETGHAIFE-ATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAA 379 Query: 320 TRISKAVHETIAEGKHTTRD----IGGSS--STTDFTNEIINKLS 358 + K++ +TIA K T D + G++ ++F E+I + Sbjct: 380 DLVIKSMEKTIAS-KVVTYDFARLMDGATEVKCSEFGEELIKNMD 423 >6C0E-A nrPDB Length = 419 Score = 360 bits (924), Expect = e-100, Method: Composition-based stats. Identities = 98/391 (25%), Positives = 173/391 (44%), Gaps = 67/391 (17%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTDHK------EGVYEA 77 + I GDG+G ++T + + +A I W + + K E Sbjct: 32 IPFIEGDGIGVDVTPPMIRVVDAAVQKAYGNKRKISWMEVYAGEKATKVYGGDQWLPKET 91 Query: 78 VESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPD---I 134 ++++K+ + +KG TP G SLNVA+R+ +D+Y + + GV + + + Sbjct: 92 LDAMKKYVVSIKGPLTTPVG-GGIRSLNVAIRQDMDLYVCLRPIRYFNGVPSPVREPWKT 150 Query: 135 DLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLKVMTRPKTE 171 D+++ REN+E ++G+E ++ + +K ++R T Sbjct: 151 DMVIFRENSEDIYAGIEWQADTPEAKKVIQFLTKEMGVKKIRFPEHCGIGVKPVSREGTT 210 Query: 172 RIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQ-----KEY--------- 217 R+ + A +A +R +VT VHK NIMK +G F++ ++ + KEY Sbjct: 211 RLVKAAIQYAIDNDRSTVTLVHKGNIMKFTEGAFKDWGYQVARDSFGAKEYQGGPWMEFK 270 Query: 218 -----PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGAN 272 I ++ +I D Q + +P + V+ T ++ G + + AA +GG G+ GAN Sbjct: 271 NPKTGKQIIINDVIADAFLQQILLRPEDYSVIATLNLNGDYISDALAAQVGGIGIAPGAN 330 Query: 273 FGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAE 332 AVFE + GQN NP ++ILS+ +ML H+G E A I + + I E Sbjct: 331 ISDQMAVFE-ATHGTAPKYAGQNKVNPGSIILSAEMMLRHMGWYEAADLIIRGMEGAI-E 388 Query: 333 GKHTTRDI------GGSSSTTDFTNEIINKL 357 K T D S++ F + +I + Sbjct: 389 AKTVTYDFERGMQGATLVSSSGFADAMIKHM 419 >2E5M-A nrPDB Length = 409 Score = 360 bits (923), Expect = e-100, Method: Composition-based stats. Identities = 115/387 (29%), Positives = 187/387 (48%), Gaps = 59/387 (15%) Query: 30 TVTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTDHK----EGVYEAV 78 + I GDG+G EIT++ + + I W + + K E Sbjct: 26 VILYIEGDGIGPEITNAAIKVINKAVERAYGSSREIKWLEVYAGEKAEKLVNDRFPKETQ 85 Query: 79 ESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI---PDID 135 E L + ++ LKG TP + G S+NVA+R LD+YAN+ K ++G+++ + +D Sbjct: 86 EMLLKYRVVLKGPLETPIGK-GWKSVNVAIRLMLDLYANIRPVKYIEGLESPLKHPEKVD 144 Query: 136 LIVIRENTEGEFSGLEH--------------------ESVPGVVESLKVMTRPKTERIAR 175 +I+ RENT+ + G+E+ E +KVM++ KT+RI R Sbjct: 145 MIIFRENTDDLYRGIEYPFNSEEAKKIRDFLRKELKVEIEDDTGIGIKVMSKYKTQRITR 204 Query: 176 FAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD---------------- 219 A +A ++ RK VT +HK N+MK +G FR E+ KEY D Sbjct: 205 LAIQYAIEHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKEYRDFIVTEEEINQGKPDQG 264 Query: 220 -IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYA 278 I ++ I DN Q + +P ++D+++ P++ G + + ALIG G++ GAN G + Sbjct: 265 KIILNDRIADNMFQQIIIRPEEYDIILAPNVNGDYISDAAGALIGNIGMLGGANIGDEGG 324 Query: 279 VFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTR 338 +FE G+NVANPT +I + LML +G NE A I KA++ I + K T+ Sbjct: 325 MFE-AIHGTAPKYAGKNVANPTGIIKAGELMLRWMGWNEAADLIEKAINMAIRD-KKVTQ 382 Query: 339 DIG-----GSSSTTDFTNEIINKLSTM 360 DI + T ++ +E+I + T+ Sbjct: 383 DIARFMGVKALGTKEYADELIKIMDTI 409 >3DMS-A nrPDB Length = 427 Score = 358 bits (919), Expect = 2e-99, Method: Composition-based stats. Identities = 107/392 (27%), Positives = 172/392 (43%), Gaps = 67/392 (17%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTDHK------EGVYEA 77 + I GDG G +IT + + +A I W I + K E Sbjct: 39 IPYIEGDGTGFDITPVMIKVVDAAVEKAYGGKKKIHWMEIYAGEKATKVYGPDVWLPEET 98 Query: 78 VESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPD---I 134 ++ LK + +KG TP G SLNVALR++LD+Y + + KGV + + + Sbjct: 99 LQVLKEYVVSIKGPLTTPVG-GGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVREPEKT 157 Query: 135 DLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLKVMTRPKTE 171 ++++ REN+E ++G+E + + +K +++ TE Sbjct: 158 NMVIFRENSEDIYAGIEWAAESEQAKKVIKFLQEEMGVKKIRFPQTSGIGIKPVSKEGTE 217 Query: 172 RIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYP------------- 218 R+ R A +A +RKSVT VHK NIMK +G FR+ + QKE+ Sbjct: 218 RLVRKAIQYAIDNDRKSVTLVHKGNIMKFTEGAFRDAGYALAQKEFGAELIDGGPWMKFK 277 Query: 219 ------DIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGAN 272 +I V I D Q + +P ++DV+ T ++ G + + AA +GG G+ GAN Sbjct: 278 NPKTGNEIVVKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGGIGIAPGAN 337 Query: 273 FGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAE 332 A+FE + G++ NP + ILS+ +ML HLG E A I A+ ++I + Sbjct: 338 LSDSVAMFE-ATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADVIISAMEKSIKQ 396 Query: 333 GKHTTRDIGG------SSSTTDFTNEIINKLS 358 K T D S + F +I + Sbjct: 397 -KRVTYDFARLMEGATQVSCSGFGQVLIENME 427 >2D4V-A nrPDB Length = 429 Score = 356 bits (915), Expect = 7e-99, Method: Composition-based stats. Identities = 107/404 (26%), Positives = 186/404 (46%), Gaps = 80/404 (19%) Query: 31 VTLIPGDGVGKEITDSVRTIFEAENIP-------IDWETINIKQTD---HKEGVY---EA 77 + I GDG+G ++T ++R++ +A I W + Q + EG Y E Sbjct: 29 IPFIEGDGIGCDVTPAMRSVVDAAVAKVYGGQRQIAWMELFAGQKAVQLYGEGQYLPDET 88 Query: 78 VESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI---PDI 134 + +++ K+ +KG TP G SLNVA+R+ LD+Y + + +G + + + Sbjct: 89 MAAIREYKVAIKGPLETPVG-GGIRSLNVAMRQDLDLYVCLRPVRYFEGTPSPMRHPEKV 147 Query: 135 DLIVIRENTEGEFSGLEHESVPGVVE-----------------------SLKVMTRPKTE 171 D+++ REN+E ++G+E + E +K ++ +E Sbjct: 148 DMVIFRENSEDIYAGIEWPAGSPEAEKIIRFLREEMGVTKIRFPDSSAIGIKPVSTEGSE 207 Query: 172 RIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYP------------- 218 R+ R +A ++ + SV+ VHK NIMK +G FR+ + ++E+ Sbjct: 208 RLIRRTIQYALEHGKPSVSLVHKGNIMKFTEGGFRDWGYALAEREFAGRVFTWRQKAAIS 267 Query: 219 -------------------DIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGA 259 + + +I DN Q + +P + V+ T ++ G + + A Sbjct: 268 KAEGKAAGQKAEQQAIADGKLIIKDVIADNFLQQILLRPEDYSVVATLNLNGDYVSDALA 327 Query: 260 ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYA 319 A +GG G+ GAN +A+FE + DI GQ ANP+++ILS+ +ML HLG E A Sbjct: 328 AEVGGIGMAPGANLSDTHAIFE-ATHGTAPDIAGQGKANPSSLILSAVMMLEHLGWGEAA 386 Query: 320 TRISKAVHETIAEGKHTTRDIGG------SSSTTDFTNEIINKL 357 I A++ TIA G+ T D+ + STT+FT +I + Sbjct: 387 QAIVAAMNATIAAGE-VTGDLAALRGDVPALSTTEFTAALIRRF 429 >1CM7-A nrPDB Length = 363 Score = 355 bits (912), Expect = 1e-98, Method: Composition-based stats. Identities = 100/358 (27%), Positives = 173/358 (48%), Gaps = 35/358 (9%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIP-----------IDWETINIKQTDHKEGV--- 74 + + ++PGDG+G E+ + +A + I+ Sbjct: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Query: 75 YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 E +++ +G H P DQ + LRK +++N+ K +G++ P Sbjct: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 Query: 133 ------DIDLIVIRENTEGEFSGL----EHESVPGVVESLKVMTRPKTERIARFAFDFAK 182 D++ +RE T G + G E +V R + ERIAR AF+ A+ Sbjct: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 Query: 183 KYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD 242 K R VT++ KAN+++ L+R I+ EI EYPD++++ + +DNA+MQ + P QFD Sbjct: 185 K-RRHKVTSIDKANVLQ-SSILWREIVNEIAT-EYPDVELAHMYIDNATMQLIKDPSQFD 241 Query: 243 VLVTPSMYGTILGNIGAALIGGPGLVAGANFGR-DYAVFEPGSRHVGLDIKGQNVANPTA 301 VL+ +++G IL + A + G G++ A+ + ++EP DI G+N+ANP A Sbjct: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPA-GGSAPDIAGKNIANPIA 300 Query: 302 MILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI--GGSSSTTDFTNEIINK 356 ILS L+L + L ++ A I +A++ + EG T D+ G ++ +TD +II + Sbjct: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIR-TGDLARGAAAVSTDEMGDIIAR 357 >1XAD-A nrPDB Length = 345 Score = 353 bits (907), Expect = 6e-98, Method: Composition-based stats. Identities = 110/352 (31%), Positives = 180/352 (51%), Gaps = 29/352 (8%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEA-----------ENIPIDWETINIKQTDHKEGVY-- 75 V ++PGDG+G E+T++ + A E P I+ E Sbjct: 1 MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKG 60 Query: 76 -EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGV------- 127 E E++ +G P + L +++RKQLD++AN+ K + + Sbjct: 61 VEEAEAVLLGSVGGPKWDQNPRELRPEKGL-LSIRKQLDLFANLRPVKVFESLSDASPLK 119 Query: 128 KTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRK 187 K I ++D +++RE T G + G + + ++P+ ER+AR AF+ A+K RK Sbjct: 120 KEYIDNVDFVIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARK-RRK 178 Query: 188 SVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTP 247 V +V KAN++++G+ +R + E+G+ YPD+ + VD +M V P +FDV+VT Sbjct: 179 HVVSVDKANVLEVGE-FWRKTVEEVGRG-YPDVALEHQYVDAMAMHLVRSPARFDVVVTG 236 Query: 248 SMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSST 307 +++G IL ++ + L G GL+ A+ GR VFEP DI G+ +ANPTA ILS+ Sbjct: 237 NIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEP-VHGSAPDIAGKGIANPTAAILSAA 295 Query: 308 LMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLS 358 +ML H GL E A ++ AV + + E D+GGS+ T FT ++ L+ Sbjct: 296 MMLEHAFGLVELARKVEDAVAKALLE--TPPPDLGGSAGTEAFTATVLRHLA 345 >1CNZ-A nrPDB Length = 363 Score = 352 bits (903), Expect = 2e-97, Method: Composition-based stats. Identities = 98/358 (27%), Positives = 175/358 (48%), Gaps = 35/358 (9%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIP-----------IDWETINIKQTDHKEGV--- 74 + + ++PGDG+G E+ + +A + I+ + Sbjct: 5 YHIAVLPGDGIGPEVMAQALKVMDAVRSRFDMRITTSHYDVGGIAIDNHGHPLPKATVEG 64 Query: 75 YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 E +++ +G + P + + LRK +++N+ K +G++ P Sbjct: 65 CEQADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 Query: 133 ------DIDLIVIRENTEGEFSGL----EHESVPGVVESLKVMTRPKTERIARFAFDFAK 182 D++ +RE T G + G E +V R + ERIAR AF+ A+ Sbjct: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 Query: 183 KYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD 242 K RK VT++ KAN+++ L+R I+ ++ K YPD++++ + +DNA+MQ + P QFD Sbjct: 185 KRRRK-VTSIDKANVLQ-SSILWREIVNDVA-KTYPDVELAHMYIDNATMQLIKDPSQFD 241 Query: 243 VLVTPSMYGTILGNIGAALIGGPGLVAGANFGR-DYAVFEPGSRHVGLDIKGQNVANPTA 301 VL+ +++G IL + A + G G++ A+ + ++EP DI G+N+ANP A Sbjct: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPA-GGSAPDIAGKNIANPIA 300 Query: 302 MILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI--GGSSSTTDFTNEIINK 356 ILS L+L + L N+ AT I +A++ + EG T D+ G ++ +TD +II + Sbjct: 301 QILSLALLLRYSLDANDAATAIEQAINRALEEG-VRTGDLARGAAAVSTDEMGDIIAR 357 >4Y1P-A nrPDB Length = 337 Score = 346 bits (888), Expect = 7e-96, Method: Composition-based stats. Identities = 116/344 (33%), Positives = 186/344 (54%), Gaps = 25/344 (7%) Query: 29 FTVTLIPGDGVGKEITDSVRTIF----EAENIPIDWETINIKQTDHKEG----VYEAVES 80 F V LI GDG+G E+ +TI E ++PI++ + T + +++ Sbjct: 3 FVVALIQGDGIGPEVVSKSKTILARLNEKFSLPIEYIEVEAGDTTKNKFGDALPKDSLRV 62 Query: 81 LKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIR 140 +++ + LKG P +T + V LR D+YAN+ KSL G++ + D+D++V+R Sbjct: 63 IEKADMILKG----PVGETA-ADVVVKLRLMYDLYANLRPAKSLPGLENKFGDVDILVVR 117 Query: 141 ENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKL 200 ENTE + GLEH GV +KV+TR + RIA+ A + A + +K V VHK+N+M++ Sbjct: 118 ENTEDLYKGLEHVISDGVTVGIKVITRAASTRIAQVALNQALR-RKKKVVCVHKSNVMRI 176 Query: 201 GDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAA 260 DGLF + + + ++ S + VD A+ V P FDV+VT + YG IL + Sbjct: 177 TDGLFAESCRNVLKGK---VEYSEMYVDAAAANLVRNPQAFDVIVTENTYGDILSDEAGQ 233 Query: 261 LIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLG------ 314 + G G+ AN G ++FEP DI G+N+ANPTA +LS +ML+ + Sbjct: 234 IAGSLGISPSANIGDRKSLFEP-VHGAAFDIAGKNIANPTAFLLSVGMMLDRMQELSGDI 292 Query: 315 -LNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357 N A + A++ +EGK+ T D+GGSS+T + + I +K+ Sbjct: 293 RYNNAAKSLRDAIYSVYSEGKYLTPDVGGSSTTDEMISAIRSKI 336 >3U1H-A nrPDB Length = 390 Score = 345 bits (886), Expect = 1e-95, Method: Composition-based stats. Identities = 109/362 (30%), Positives = 180/362 (49%), Gaps = 36/362 (9%) Query: 28 RFTVTLIPGDGVGKEITDSVRTIFEAENIP-----------IDWETINIKQTDHKEGVYE 76 + + ++PGDG+G E+ ++ + +A I I+ T E + Sbjct: 23 KKKIAVLPGDGIGPEVMEAAIEVLKAVAERFGHEFEFEYGLIGGAAIDEAGTPLPEETLD 82 Query: 77 AV---ESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGV------ 127 +++ +G P++ L + +RK LD++AN+ K + Sbjct: 83 VCRGSDAILLGAVGGPKWDQNPSELRPEKGL-LGIRKGLDLFANLRPVKVYDSLADASPL 141 Query: 128 -KTRIPDIDLIVIRENTEGEFSGLE---HESVPGVVESLKVMTRPKTERIARFAFDFAKK 183 K I +DL+++RE T G + G +E + TR + ERI R AF+ A Sbjct: 142 KKEVIEGVDLVIVRELTGGLYFGEPSERYEEGEEAAVDTLLYTREEIERIIRKAFELALT 201 Query: 184 YNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDV 243 +K VT+V KAN+++ L+R + E+ KEYPD+++ ++VDNA+MQ + P QFDV Sbjct: 202 -RKKKVTSVDKANVLE-SSRLWREVAEEVA-KEYPDVELEHMLVDNAAMQLIRNPRQFDV 258 Query: 244 LVTPSMYGTILGNIGAALIGGPGLVAGANFG-RDYAVFEPGSRHVGLDIKGQNVANPTAM 302 +VT +M+G IL + + + G G++ A+ ++EP DI G+ +ANP A Sbjct: 259 IVTENMFGDILSDEASMITGSLGMLPSASLSTDGLGLYEP-VHGSAPDIAGKGIANPLAT 317 Query: 303 ILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI----GGSSSTTDFTNEIINKL 357 ILS+ +ML + GL E A I KAV + +AEG + T DI G STT+ T+E+ + Sbjct: 318 ILSAAMMLRYSFGLEEEAKAIEKAVEKVLAEG-YRTADIAKPGGKYVSTTEMTDEVKAAV 376 Query: 358 ST 359 Sbjct: 377 VD 378 >1WPW-A nrPDB Length = 336 Score = 345 bits (885), Expect = 2e-95, Method: Composition-based stats. Identities = 115/344 (33%), Positives = 184/344 (53%), Gaps = 25/344 (7%) Query: 29 FTVTLIPGDGVGKEITDSVRTIF----EAENIPIDWETINIKQTDHKEG----VYEAVES 80 FTV LI GDG+G EI + I E ++PI++ + ++++ Sbjct: 2 FTVALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEAGDRALARYGEALPKDSLKI 61 Query: 81 LKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIR 140 + + I LKG P ++ + V LR+ D+YAN+ KS+ G+ T+ ++D++++R Sbjct: 62 IDKADIILKG----PVGESA-ADVVVKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVR 116 Query: 141 ENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKL 200 ENTE + G EH GV +K++TR +ERIA+ +FA + RK VT VHKAN+M++ Sbjct: 117 ENTEDLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALR-RRKKVTCVHKANVMRI 175 Query: 201 GDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAA 260 DGLF + + + ++ S + VD A+ V P FDV+VT ++YG IL + + Sbjct: 176 TDGLFAEACRSVLKGK---VEYSEMYVDAAAANLVRNPQMFDVIVTENVYGDILSDEASQ 232 Query: 261 LIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHL------- 313 + G G+ AN G A+FEP DI G+N+ NPTA +LS ++M + Sbjct: 233 IAGSLGIAPSANIGDKKALFEP-VHGAAFDIAGKNIGNPTAFLLSVSMMYERMYELSNDD 291 Query: 314 GLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357 + + + A++ E K T D+GG+++T D NEI NKL Sbjct: 292 RYIKASRALENAIYLVYKERKALTPDVGGNATTDDLINEIYNKL 335 >1IDM-A nrPDB Length = 343 Score = 344 bits (883), Expect = 3e-95, Method: Composition-based stats. Identities = 108/351 (30%), Positives = 182/351 (51%), Gaps = 29/351 (8%) Query: 29 FTVTLIPGDGVGKEITDSVRTIF----EAENIPIDWETINIKQTD----HKEGVYEAVES 80 V ++PGDG+G E+T++ + EAE + + +E + + Sbjct: 1 MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKG 60 Query: 81 LKRNKIGLKGL-----WHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP--- 132 ++ + L G W T + + G ++LRK D++AN+ K G++ P Sbjct: 61 VEEAEAVLLGSVGGPKWGTGSVRPEQG--LLSLRKSQDLFANLRPAKVFPGLERLSPLKE 118 Query: 133 ----DIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKS 188 +D++++RE T G + G + + ++P+ ER+AR AF+ A+K RK Sbjct: 119 EIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARK-RRKH 177 Query: 189 VTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPS 248 V +V KAN++++G+ +R + E+G+ YPD+ + VD +M V P +FDV+VT + Sbjct: 178 VVSVDKANVLEVGE-FWRKTVEEVGRG-YPDVALEHQYVDAMAMHLVRSPARFDVVVTGN 235 Query: 249 MYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTL 308 ++G IL ++ + L G GL+ A+ GR VFEP DI G+ +ANPTA ILS+ + Sbjct: 236 IFGDILSDLASVLPGSLGLLPSASLGRGTPVFEP-VHGSAPDIAGKGIANPTAAILSAAM 294 Query: 309 MLNH-LGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLS 358 ML H GL E A ++ AV + + E D+GGS+ T FT ++ L+ Sbjct: 295 MLEHAFGLVELARKVEDAVAKALLE--TPPPDLGGSAGTEAFTATVLRHLA 343 >3VMK-A nrPDB Length = 375 Score = 344 bits (882), Expect = 4e-95, Method: Composition-based stats. Identities = 94/364 (25%), Positives = 168/364 (46%), Gaps = 37/364 (10%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIP-----------IDWETINIKQTDHKEGV--- 74 + + ++ GDG+G E+ R + A + I+ E Sbjct: 14 YQIAVLAGDGIGPEVMAEARKVLAAVEKRFDLSIEYSEYDVGGAAIDNHGCPLPEATLKG 73 Query: 75 YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 EA +++ +G H P + + LR +++ N+ K G++ P Sbjct: 74 CEAADAVLFGSVGGPKWEHLPPNDQPERGALLPLRGHFELFCNMRPAKLHPGLEHMSPLR 133 Query: 133 ------DIDLIVIRENTEGEFSGLE----HESVPGVVESLKVMTRPKTERIARFAFDFAK 182 D++ +RE T G + G E +R + RIA+ AF+ A+ Sbjct: 134 SDISEKGFDILCVRELTGGIYFGKPKGRQGEGENEEAFDTMRYSRKEIRRIAKIAFESAQ 193 Query: 183 KYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD 242 RK VT+V KAN++ L+R ++ E+ K+YPD+++ I +DNA+MQ + +P++FD Sbjct: 194 G-RRKKVTSVDKANVLACS-VLWREVVEEVA-KDYPDVELEHIYIDNATMQLLRRPNEFD 250 Query: 243 VLVTPSMYGTILGNIGAALIGGPGLVAGANFG-RDYAVFEPGSRHVGLDIKGQNVANPTA 301 V++ +++G I+ + A L G GL+A + + + ++EP DI GQ +ANP A Sbjct: 251 VMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQGFGMYEPA-GGSAPDIAGQGIANPVA 309 Query: 302 MILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIGG-----SSSTTDFTNEIIN 355 ILS+ L+L H L L + A I AV + +++G T + + ST+ + I Sbjct: 310 QILSAALLLRHSLKLEDAALAIEAAVSKALSDGYLTCELLPASERSQAKSTSQMGDYIAQ 369 Query: 356 KLST 359 ++ Sbjct: 370 AIAE 373 >3VMJ-A nrPDB Length = 375 Score = 343 bits (880), Expect = 7e-95, Method: Composition-based stats. Identities = 93/363 (25%), Positives = 167/363 (46%), Gaps = 37/363 (10%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIP----IDWETINIKQ-------TDHKEGV--- 74 + + ++ GDG+G E+ R + +A I++ ++ E Sbjct: 14 YQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKG 73 Query: 75 YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 EA +++ +G P ++ + LR +++ N+ K G++ P Sbjct: 74 CEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLR 133 Query: 133 ------DIDLIVIRENTEGEFSGLE----HESVPGVVESLKVMTRPKTERIARFAFDFAK 182 D++ +RE T G + G E +R + RIAR AF+ A+ Sbjct: 134 SDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAAR 193 Query: 183 KYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD 242 RK VT+V KAN++ L+R ++ E+ ++PD+++ I +DNA+MQ + +P +FD Sbjct: 194 G-RRKKVTSVDKANVLACS-VLWRQVVEEVA-VDFPDVELEHIYIDNATMQLLRRPDEFD 250 Query: 243 VLVTPSMYGTILGNIGAALIGGPGLVAGANFGR-DYAVFEPGSRHVGLDIKGQNVANPTA 301 V++ +++G IL + A L G GL++ A+ + +FEP DI G+ +ANP A Sbjct: 251 VMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGLFEPA-GGSAPDIAGKGIANPIA 309 Query: 302 MILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIG-----GSSSTTDFTNEIIN 355 ILS+ LML H L E A+ I +AV + + G T + + +T + I + Sbjct: 310 QILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIAD 369 Query: 356 KLS 358 + Sbjct: 370 AVK 372 >1VLC-A nrPDB Length = 366 Score = 342 bits (877), Expect = 1e-94, Method: Composition-based stats. Identities = 114/359 (31%), Positives = 176/359 (49%), Gaps = 33/359 (9%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIP-----------IDWETINIKQTDHKE---GV 74 + ++PGDG+G E+ + E I + I+ E + Sbjct: 13 MKIAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGGDAIDRFGEPLPEETKKI 72 Query: 75 YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 +++ +G P ++ +ALRK L++YAN+ K + + P Sbjct: 73 CLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPLK 132 Query: 133 ------DIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNR 186 +DL+ +RE + G + G + R ERIAR AF+ A K R Sbjct: 133 EKVIGSGVDLVTVRELSYGVYYGQPRGLDEEKGFDTMIYDRKTVERIARTAFEIA-KNRR 191 Query: 187 KSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVT 246 K VT+V KAN++ L+R ++ E+ +EYPD++++ I VDNA+MQ + KP QFDV++T Sbjct: 192 KKVTSVDKANVL-YSSMLWRKVVNEVA-REYPDVELTHIYVDNAAMQLILKPSQFDVILT 249 Query: 247 PSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSS 306 +M+G IL + AAL G GL+ A+FG ++EP DI G+N+ANP A ILS Sbjct: 250 TNMFGDILSDESAALPGSLGLLPSASFGDK-NLYEPA-GGSAPDIAGKNIANPIAQILSL 307 Query: 307 TLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIG----GSSSTTDFTNEIINKLSTM 360 +ML H G+ E A +I +AV I EG + TRDI + ST+ + I KL + Sbjct: 308 AMMLEHSFGMVEEARKIERAVELVIEEG-YRTRDIAEDPEKAVSTSQMGDLICKKLEEI 365 >3VML-A nrPDB Length = 375 Score = 342 bits (877), Expect = 2e-94, Method: Composition-based stats. Identities = 93/363 (25%), Positives = 168/363 (46%), Gaps = 37/363 (10%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIP----IDWETINIKQ-------TDHKEGV--- 74 + + ++ GDG+G E+ R + +A I++ ++ E Sbjct: 14 YQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKG 73 Query: 75 YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 EA +++ +G H P + + LR +++ N+ K G++ P Sbjct: 74 CEAADAVLFGSVGGPKWEHLPPNDQPERGALLPLRGHFELFCNMRPAKLHPGLEHMSPLR 133 Query: 133 ------DIDLIVIRENTEGEFSGLE----HESVPGVVESLKVMTRPKTERIARFAFDFAK 182 D++ +RE T G + G E +R + RIA+ AF+ A+ Sbjct: 134 SDISEKGFDILCVRELTGGIYFGKPKGRQGEGENEEAFDTMRYSRKEIRRIAKIAFESAQ 193 Query: 183 KYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD 242 RK VT+V KAN++ L+R ++ E+ K+YPD+++ I +DNA+MQ + +P++FD Sbjct: 194 G-RRKKVTSVDKANVLACS-VLWREVVEEVA-KDYPDVELEHIYIDNATMQLLRRPNEFD 250 Query: 243 VLVTPSMYGTILGNIGAALIGGPGLVAGANFG-RDYAVFEPGSRHVGLDIKGQNVANPTA 301 V++ +++G I+ + A L G GL+A + + + ++EP DI GQ +ANP A Sbjct: 251 VMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQGFGMYEPA-GGSAPDIAGQGIANPVA 309 Query: 302 MILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIG-----GSSSTTDFTNEIIN 355 ILS+ L+L H L L + A I AV + + G T + + +T + I + Sbjct: 310 QILSAALLLRHSLKLEDAALAIEAAVSKALNSGYLTGELLSSDQRHKAKTTVQMGDFIAD 369 Query: 356 KLS 358 + Sbjct: 370 AVK 372 >3TY3-A nrPDB Length = 366 Score = 341 bits (876), Expect = 2e-94, Method: Composition-based stats. Identities = 118/361 (32%), Positives = 181/361 (50%), Gaps = 37/361 (10%) Query: 28 RFTVTLIPGDGVGKEITDSVRTIFEA--ENIPIDWETINIKQTDHKEGVYE--------- 76 R + LIP DG+GKE+ + R + E + ++ I++ D G +E Sbjct: 10 RIVLGLIPADGIGKEVVPAARRLMENLPAKHKLKFDFIDL---DAGWGTFERTGKALPER 66 Query: 77 AVESLK-RNKIGLKGLWHTPADQ-TGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDI 134 VE LK L G +P + G+ S VALRK++ +YANV KSL G K + + Sbjct: 67 TVERLKTECNAALFGAVQSPTHKVAGYSSPIVALRKKMGLYANVRPVKSLDGAKGK--PV 124 Query: 135 DLIVIRENTEGEFSGLEHESVPG----VVESLKVMTRPKTERIARFAFDFAKK------- 183 DL+++RENTE + E V E+++ ++ + +I + AF+ AK Sbjct: 125 DLVIVRENTECLYVKEERMVQNTPGKRVAEAIRRISEEASTKIGKMAFEIAKSRQKIRES 184 Query: 184 -----YNRKSVTAVHKANIMKLGDGLFRNIIT--EIGQKEYPDIDVSSIIVDNASMQAVA 236 + + VT +HK+N+M + DGLFR + Y I+V IVD+ + Sbjct: 185 GTYSIHKKPLVTIIHKSNVMSVTDGLFRESCRHAQSLDPSYASINVDEQIVDSMVYRLFR 244 Query: 237 KPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNV 296 +P FDV+V P++YG IL + A+LIG GLV AN G ++ + EP DI G+ + Sbjct: 245 EPECFDVVVAPNLYGDILSDGAASLIGSLGLVPSANVGDNFVMSEP-VHGSAPDIAGRGI 303 Query: 297 ANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINK 356 ANP A S LML +G + A I AV + + EGK T D+GG S T + T+ ++ Sbjct: 304 ANPVATFRSVALMLEFMGHQDAAADIYTAVDKVLTEGKVLTPDLGGKSGTNEITDAVLAN 363 Query: 357 L 357 + Sbjct: 364 I 364 >3FMX-X nrPDB Length = 364 Score = 340 bits (873), Expect = 5e-94, Method: Composition-based stats. Identities = 110/361 (30%), Positives = 171/361 (47%), Gaps = 32/361 (8%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIP----IDWETINIKQTDH-----KEGVYEAVE 79 F + IPGDG+G E+ + EA + ++++T D+ K + E Sbjct: 6 FRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDDWAE 65 Query: 80 SLKRNKIGLKGLWHTPADQTGHGSLNVAL---RKQLDIYANVALFKSLKGVKT-----RI 131 LK+ G P H SL +L R++ D Y N+ + GV ++ Sbjct: 66 QLKQYDAIYFGAVGWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALANRKV 125 Query: 132 PDIDLIVIRENTEGEFS---GLEHESVP-GVVESLKVMTRPKTERIARFAFDFAKKYNRK 187 DID +V+RENTEGE+S G+ E+ +V + TR +RI ++AFD A+K RK Sbjct: 126 GDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAEKRERK 185 Query: 188 SVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTP 247 VT+ K+N M + + + TE YP + +D + V +P +FDV+V Sbjct: 186 HVTSATKSNGMAIS-MPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDVVVAS 244 Query: 248 SMYGTILGNIGAALIGGPGLVAGANFGRDY---AVFEPGSRHVGLDIKGQNVANPTAMIL 304 +++G IL ++G A G G+ AN + ++FEP DI G+N+ANP AMI Sbjct: 245 NLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEP-VHGSAPDIFGKNIANPIAMIW 303 Query: 305 SSTLMLNHLGLNE-----YATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLST 359 S LML LG + + A+ IA+G T D+GG+ ST I + L+ Sbjct: 304 SGALMLEFLGQGDERYQRAHDDMLNAIERVIADGS-VTPDMGGTLSTQQVGAAISDTLAR 362 Query: 360 M 360 + Sbjct: 363 L 363 >5HN5-A nrPDB Length = 353 Score = 338 bits (866), Expect = 3e-93, Method: Composition-based stats. Identities = 106/336 (31%), Positives = 182/336 (54%), Gaps = 19/336 (5%) Query: 29 FTVTLIPGDGVGKEITDSVRTIFEAENIPIDWET----INIKQTDHKEGVYEAVESLKRN 84 + V +IPGDG+G E+ D + +A + +E +++ Q E +E ++R+ Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGRVRFEYYEGGVDVFQECGSPIREEDLEEIRRS 61 Query: 85 KIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTE 144 L G TP D G+ SL + LRK+L +YAN+ + L+ + +++++REN+E Sbjct: 62 DAVLFGATTTPFDLPGYRSLILTLRKELGLYANLRIIPDLRTGR------EIVIVRENSE 115 Query: 145 GEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGL 204 G + G+ V G ++++TR ERIARFA + AK +T VHKAN++ GD Sbjct: 116 GLYFGI-GAVVNGRAVDVRLITREGAERIARFAVEQAKARG-SFITFVHKANVLT-GDKF 172 Query: 205 FRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGG 264 FR I+ E+ +E ++V I+D+ +++ V P + V+++ +++G IL ++ G Sbjct: 173 FRRIVREVAGEE--GVEVRDAIIDSFTIKLVRNPWEHGVILSENLFGDILSDLATVHAGS 230 Query: 265 PGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISK 324 G+V N+G A+FEP DI G+ +ANP ILS ++L++LGL+ + I Sbjct: 231 IGIVPSGNYGDGIALFEP-VHGSAPDIAGKGIANPIGAILSGAMLLDYLGLD--GSLIRA 287 Query: 325 AVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM 360 AV + G+ T D+GG + T D II ++ + Sbjct: 288 AVRGYVVNGE-LTPDMGGRARTEDVVRGIIGEIEDL 322 >1V5B-A nrPDB Length = 366 Score = 333 bits (853), Expect = 1e-91, Method: Composition-based stats. Identities = 109/365 (29%), Positives = 183/365 (50%), Gaps = 42/365 (11%) Query: 28 RFTVTLIPGDGVGKEITDSVRTIFE-----------AENIPIDWETINIKQTDHKEGVYE 76 + + ++PGDG+G E+ D+ + + EN I I+ T E E Sbjct: 2 KMKLAVLPGDGIGPEVMDAAIRVLKTVLDNDGHEAVFENALIGGAAIDEAGTPLPE---E 58 Query: 77 AVESLKRNKIGLKG------LWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGV--- 127 ++ +R+ L G H PA L + LRK++ ++AN+ K+ + Sbjct: 59 TLDICRRSDAILLGAVGGPKWDHNPASLRPEKGL-LGLRKEMGLFANLRPVKAYATLLNA 117 Query: 128 ----KTRIPDIDLIVIRENTEGEFSGLEHES---VPGVVESLKVMTRPKTERIARFAFDF 180 + R+ ++DL+++RE T G + G E V TR + ERI AF Sbjct: 118 SPLKRERVENVDLVIVRELTGGLYFGRPSERRGPGENEVVDTLAYTREEIERIIEKAFQL 177 Query: 181 AKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQ 240 A+ RK + +V KAN+++ ++R I E +K YPD+++S ++VD+ +MQ +A P Q Sbjct: 178 AQ-IRRKKLASVDKANVLE-SSRMWREIAEETAKK-YPDVELSHMLVDSTAMQLIANPGQ 234 Query: 241 FDVLVTPSMYGTILGNIGAALIGGPGLVAGANF-GRDYAVFEPGSRHVGLDIKGQNVANP 299 FDV+VT +M+G IL ++ + + G G++ A+ + ++EP DI GQ ANP Sbjct: 235 FDVIVTENMFGDILSDLASVITGSLGMLPSASLRSDRFGMYEP-VHGSAPDIAGQGKANP 293 Query: 300 TAMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI----GGSSSTTDFTNEII 354 +LS+ LML + GL + A I KAV + + +G + T D+ G ST + T+ +I Sbjct: 294 LGTVLSAALMLRYSFGLEKEAAAIEKAVDDVLQDG-YCTGDLQVANGKVVSTIELTDRLI 352 Query: 355 NKLST 359 KL+ Sbjct: 353 EKLNN 357 >1XGV-A nrPDB Length = 435 Score = 332 bits (851), Expect = 2e-91, Method: Composition-based stats. Identities = 100/390 (25%), Positives = 173/390 (44%), Gaps = 63/390 (16%) Query: 30 TVTLIPGDGVGKEITDSVRTIFEAENIPI--------DWETINIKQTDHKEG---VYEAV 78 V I GDGVG E+ +S + +A + WE + K G + Sbjct: 37 VVAFIRGDGVGPEVVESALKVVDAAVKKVYGGSRRIVWWELLAGHLAREKCGELLPKATL 96 Query: 79 ESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSL-KGVKTRIPD-IDL 136 E ++ ++ LKG TP TG+ SLNVA+R+ LD+YAN+ + + + D +D+ Sbjct: 97 EGIRLARVALKGPLETPVG-TGYRSLNVAIRQALDLYANIRPVRYYGQPAPHKYADRVDM 155 Query: 137 IVIRENTEGEFSGLEHESVPGVV--------------------ESLKVMTRPKTERIARF 176 ++ RENTE ++G+E +K ++R T R+ Sbjct: 156 VIFRENTEDVYAGIEWPHDSPEAARIRRFLAEEFGISIREDAGIGVKPISRFATRRLMER 215 Query: 177 AFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD----------------- 219 A ++A + VT +HK NIMK +G F E+ +++ + Sbjct: 216 ALEWALRNGNTVVTIMHKGNIMKYTEGAFMRWAYEVALEKFREHVVTEQEVQEKYGGVRP 275 Query: 220 ---IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD 276 I V+ I DN Q + +P + V+V P++ G + + +AL+GG G+ AG N G Sbjct: 276 EGKILVNDRIADNMLQQIITRPWDYQVIVAPNLNGDYISDAASALVGGIGMAAGMNMGDG 335 Query: 277 YAVFEPGSRHVGLDIKGQNVANPTAMILSSTLML-NHLGLNEYATRISKAVHETIAEGKH 335 AV EP G+++ NP+A ILS++L++ +G E + + A+ + + K Sbjct: 336 IAVAEP-VHGTAPKYAGKDLINPSAEILSASLLIGEFMGWREVKSIVEYAIRKAVQS-KK 393 Query: 336 TTRDIGGS------SSTTDFTNEIINKLST 359 T+D+ T+++T +I + Sbjct: 394 VTQDLARHMPGVQPLRTSEYTETLIAYIDE 423 >3UDO-A nrPDB Length = 361 Score = 321 bits (823), Expect = 3e-88, Method: Composition-based stats. Identities = 96/357 (26%), Positives = 171/357 (47%), Gaps = 32/357 (8%) Query: 29 FTVTLIPGDGVGKEITDSVRTI-----------FEAENIPIDWETIN---IKQTDHKEGV 74 + V ++ GDG+G + I FE I +I+ + +D + Sbjct: 7 YKVAVLAGDGIGPLVMKEALKILTFIAQKYNFSFELNEAKIGGASIDAYGVALSDETLKL 66 Query: 75 YEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 E +++ +G + P DQ + + LRK +++AN+ K + + P Sbjct: 67 CEQSDAILFGSVGGPKWDNLPIDQRPERASLLPLRKHFNLFANLRPCKIYESLTHASPLK 126 Query: 133 ------DIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNR 186 +D++ +RE T G + G + + ++ T+ + ERIAR AF+ A+ + Sbjct: 127 NEIIQKGVDILCVRELTGGIYFGKQ-DLGKESAYDTEIYTKKEIERIARIAFESAR-IRK 184 Query: 187 KSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVT 246 K V + KAN++ L+R ++ + K+Y DI++ + VDNA+MQ V P FDV++ Sbjct: 185 KKVHLIDKANVLA-SSILWREVVANVA-KDYQDINLEYMYVDNAAMQIVKNPSIFDVMLC 242 Query: 247 PSMYGTILGNIGAALIGGPGLVAGANFGR-DYAVFEPGSRHVGLDIKGQNVANPTAMILS 305 +++G IL + AA+ G GL++ A+ + ++EP DI N+ANP A ILS Sbjct: 243 SNLFGDILSDELAAINGSLGLLSSASLNDKGFGLYEPA-GGSAPDIAHLNIANPIAQILS 301 Query: 306 STLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIGGSS--STTDFTNEIINKLST 359 + LML + + A I A+ +A+GK T+D+ S +T + + I+ L Sbjct: 302 AALMLKYSFKEEQAAQDIENAISLALAQGK-MTKDLNAKSYLNTDEMGDCILEILKE 357 >1A05-A nrPDB Length = 358 Score = 318 bits (815), Expect = 2e-87, Method: Composition-based stats. Identities = 101/359 (28%), Positives = 165/359 (45%), Gaps = 36/359 (10%) Query: 30 TVTLIPGDGVGKEITDSVRTIFEAE-----------NIPIDWETINIKQTDHKEG---VY 75 + + GDG+G EI + R + +A + ++ + Sbjct: 3 KIAIFAGDGIGPEIVAAARQVLDAVDQAAHLGLRCTEGLVGGAALDASDDPLPAASLQLA 62 Query: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGV-------K 128 A +++ +G P + L + LRK LD+YAN+ + + Sbjct: 63 MAADAVILGAVGGPRWDAYPPAKRPEQGL-LRLRKGLDLYANLRPAQIFPQLLDASPLRP 121 Query: 129 TRIPDIDLIVIRENTEGEFSGLEH--ESVPGVVESLK--VMTRPKTERIARFAFDFAKKY 184 + D+D++V+RE T + G E + G V + RIA AF A+ Sbjct: 122 ELVRDVDILVVRELTGDIYFGQPRGLEVIDGKRRGFNTMVYDEDEIRRIAHVAFRAAQG- 180 Query: 185 NRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVL 244 RK + +V KAN+++ L+R ++TE+ ++YPD+ +S + VDNA+MQ + P QFDVL Sbjct: 181 RRKQLCSVDKANVLETT-RLWREVVTEVA-RDYPDVRLSHMYVDNAAMQLIRAPAQFDVL 238 Query: 245 VTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMIL 304 +T +M+G IL + + L G G++ A+ G A++EP DI GQ+ ANP A IL Sbjct: 239 LTGNMFGDILSDEASQLTGSIGMLPSASLGEGRAMYEP-IHGSAPDIAGQDKANPLATIL 297 Query: 305 SSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIGG----SSSTTDFTNEIINKLS 358 S +ML H L +A R+ AV + +G T DI T ++N L+ Sbjct: 298 SVAMMLRHSLNAEPWAQRVEAAVQRVLDQG-LRTADIAAPGTPVIGTKAMGAAVVNALN 355 >5J32-A nrPDB Length = 403 Score = 313 bits (802), Expect = 8e-86, Method: Composition-based stats. Identities = 103/366 (28%), Positives = 172/366 (46%), Gaps = 42/366 (11%) Query: 28 RFTVTLIPGDGVGKEITDSVRTI-----------FEAENIPIDWETINIKQTDHKEGVYE 76 R+T+TL+PGDG+G E+ + + F +PI +++ E E Sbjct: 40 RYTITLLPGDGIGPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPE---E 96 Query: 77 AVESLKRNKIGLKGL-----WHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGV---- 127 + + K + L G W + +R L ++AN+ L + Sbjct: 97 TISAAKESDAVLLGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDAS 156 Query: 128 ---KTRIPDIDLIVIRENTEGEFSGLEH-----ESVPGVVESLKVMTRPKTERIARFAFD 179 + +DL+V+RE T G + G E+ V + +V + +RIAR AF+ Sbjct: 157 TLKREVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFE 216 Query: 180 FAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPH 239 A+K R + +V KAN+++ L+R +T + EYPD+++S + VDNA+MQ V P Sbjct: 217 TARK-RRGKLCSVDKANVLE-ASILWRKRVTALAS-EYPDVELSHMYVDNAAMQLVRDPK 273 Query: 240 QFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGR-DYAVFEPGSRHVGLDIKGQNVAN 298 QFD +VT +++G IL + + + G G++ A+ +FEP DI GQ+ AN Sbjct: 274 QFDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEP-IHGSAPDIAGQDKAN 332 Query: 299 PTAMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI--GGS--SSTTDFTNEI 353 P A ILS+ ++L + LG + A RI AV + G T DI G+ + E+ Sbjct: 333 PLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNGFR-TGDIYSAGTKLVGCKEMGEEV 391 Query: 354 INKLST 359 + + + Sbjct: 392 LKSVDS 397 >4IWH-A nrPDB Length = 363 Score = 305 bits (782), Expect = 1e-83, Method: Composition-based stats. Identities = 92/360 (25%), Positives = 161/360 (44%), Gaps = 36/360 (10%) Query: 29 FTVTLIPGDGVGKEITDSVRTI-------FEAENIPIDWETINIKQTDHKEGVYEAVESL 81 + ++PGDG+G EI + + FE E+ P+ + + Sbjct: 9 MKIAVLPGDGIGPEIVNEAVKVLNALDEKFELEHAPVGGAGYEASGHPLPDATLALAKEA 68 Query: 82 KRNKIGLKGLWHTPADQTGHGS--LNVALRKQLDIYANVALFKSLKGV-------KTRIP 132 G G W + + + LRK L+++AN + + Sbjct: 69 DAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASPLKPELVA 128 Query: 133 DIDLIVIRENTEGEFSGLEHESVP-------GVVESLKV--MTRPKTERIARFAFDFAKK 183 +D++++RE + G G E + P+ RIA AF A+K Sbjct: 129 GLDILIVRELNGDIYFGQPRGVRAAPDGPFAGEREGFDTMRYSEPEVRRIAHVAFQAAQK 188 Query: 184 YNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDV 243 K + +V K+N+++ +R+++ ++ KEY D+++S + VDNA+MQ P QFDV Sbjct: 189 -RAKKLLSVDKSNVLE-TSQFWRDVMIDV-SKEYADVELSHMYVDNAAMQLAKAPKQFDV 245 Query: 244 LVTPSMYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEPGSRHVGLDIKGQNVANPTAM 302 +VT +M+G IL + + L G G++ A+ ++ ++EP S DI G+ +ANP A Sbjct: 246 IVTGNMFGDILSDEASMLTGSIGMLPSASLDKNNKGLYEP-SHGSAPDIAGKGIANPLAT 304 Query: 303 ILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDIG----GSSSTTDFTNEIINKL 357 ILS+ ++L + L E A RI +AV + +G + T DI T + ++ L Sbjct: 305 ILSAAMLLRYSLNRAEQADRIERAVKTVLEQG-YRTGDIATPGCRQVGTAAMGDAVVAAL 363 >2G4O-A nrPDB Length = 337 Score = 289 bits (740), Expect = 1e-78, Method: Composition-based stats. Identities = 100/331 (30%), Positives = 168/331 (50%), Gaps = 22/331 (6%) Query: 30 TVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDH----KEGVYEAVESLKRNK 85 + +I GDG+G E+T + +A + + ++ + V L+ + Sbjct: 3 KLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHD 62 Query: 86 IGLKGLWHTPADQTG--HGSLNVALRKQLDIYANVALFKSLKGVKTRI---PDIDLIVIR 140 L G P+ +G L + LR +LD + N+ + GV + + P ID +V+R Sbjct: 63 AILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVR 122 Query: 141 ENTEGEFSG----LEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKAN 196 E TEG ++G + + V + V T R+ AF+ A++ RK +T VHK N Sbjct: 123 EGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARR-RRKHLTLVHKTN 181 Query: 197 IMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGN 256 ++ GL+ + E+G+ YPD++V+ VD A++ + P +FDV+VT +++G I+ + Sbjct: 182 VLTFAGGLWLRTVDEVGEC-YPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITD 240 Query: 257 IGAALIGGPGLVAGANFGRDYA---VFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHL 313 + AA+ GG GL A N A +FEP DI GQ +A+PTA I+S L+L+HL Sbjct: 241 LAAAVCGGIGLAASGNIDATRANPSMFEP-VHGSAPDIAGQGIADPTAAIMSVALLLSHL 299 Query: 314 GLNEYATRISKAVHETIA---EGKHTTRDIG 341 G ++ A R+ +AV +A + T D+G Sbjct: 300 GEHDAAARVDRAVEAHLATRGSERLATSDVG 330 >5I96-A nrPDB Length = 458 Score = 157 bits (397), Expect = 8e-39, Method: Composition-based stats. Identities = 58/229 (25%), Positives = 83/229 (36%), Gaps = 40/229 (17%) Query: 166 TRPKTERIARFAFDFA--KKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYP----- 218 T A F +A KK+ T K I+K DG F++I EI K Y Sbjct: 224 TDESISGFAHSCFQYAIQKKWPLYMST---KNTILKAYDGRFKDIFQEIFDKHYKTDFDK 280 Query: 219 -DIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDY 277 I ++D+ Q + F V + G + +I A G GL+ D Sbjct: 281 NKIWYEHRLIDDMVAQVLKSSGGF-VWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDG 339 Query: 278 AVFEPG------SRHVGLDIKGQNVA-NPTAMILSSTLMLNHLG-------LNEYATRIS 323 E +RH KG+ + NP A I + T L H G L +A + Sbjct: 340 KTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLE 399 Query: 324 KAVHETIAEGKHTTRDIGGS-------------SSTTDFTNEIINKLST 359 K ET+ G T+D+ G +TTDF + I + L Sbjct: 400 KVCVETVESGA-MTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDR 447 >2QFY-A nrPDB Length = 427 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 66/396 (16%), Positives = 133/396 (33%), Gaps = 74/396 (18%) Query: 34 IPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHK----EGVYEAVESLKRNKIGLK 89 + GD + + I D ++ + +D + ++ + +A E++K+ +G+K Sbjct: 28 LDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIK 87 Query: 90 GLWHTPADQT--------GHGSLNVALRKQLDIYANVALFKSLKGVKTRIP--DIDLIVI 139 TP + S N +R L + + +P + +I+ Sbjct: 88 CATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPI-VIPRIPRLVPRWEKPIIIG 146 Query: 140 RENTEGEFSG---------------LEHESVPGVVESLKVM-------------TRPKTE 171 R ++ + ++LKV T E Sbjct: 147 RHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIE 206 Query: 172 RIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD------IDVSSI 225 A +F A + ++ K I+K DG F++I E+ + +Y I Sbjct: 207 GFAHSSFKLAID-KKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHR 265 Query: 226 IVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPG-- 283 ++D+ Q + F ++ + G + +I A G GL+ D FE Sbjct: 266 LIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAA 324 Query: 284 ----SRHVGLDIKGQNVA-NPTAMILSSTLMLNHLGLNE-------YATRISKAVHETIA 331 +RH KG+ + N A I + + L G + +A + A T+ Sbjct: 325 HGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQ 384 Query: 332 EGKHTTRDIG---------GSSSTTDFTNEIINKLS 358 + T+D+ +T +F + + +L Sbjct: 385 QDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQ 420 >6BL1-B nrPDB Length = 425 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 69/391 (17%), Positives = 134/391 (34%), Gaps = 84/391 (21%) Query: 48 RTIFEAENIPIDWETINIKQTDHKEGVY-----------EAVESLKRNKIGLKGLWHTPA 96 R I+E + + + + + G+ +A E++K++ +G+K TP Sbjct: 20 RIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPD 79 Query: 97 DQT--------GHGSLNVALRKQLD--IYANVALFKSLKGVKTRIPDIDLIVIRENTEGE 146 ++ S N +R L ++ + K++ + + +I+ R + Sbjct: 80 EKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVK-PIIIGRHAYGDQ 138 Query: 147 FSGLE--------------------------HESVPGVVESLKVMTRPKT-ERIARFAFD 179 + + H G ++ + + K+ E A +F Sbjct: 139 YRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQ 198 Query: 180 FAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD------IDVSSIIVDNASMQ 233 A + K I+K DG F++I EI K+Y I ++D+ Q Sbjct: 199 MALSKGWP-LYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQ 257 Query: 234 AVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPG------SRHV 287 A+ F + + G + + A G G++ D E +RH Sbjct: 258 AMKSEGGF-IWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHY 316 Query: 288 GLDIKGQNVA-NPTAMILSSTLMLNHLGLNE-------YATRISKAVHETIAEGKHTTRD 339 + KGQ + NP A I + T L H + +A + + ETI G T+D Sbjct: 317 RMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAG-FMTKD 375 Query: 340 IGGS------------SSTTDFTNEIINKLS 358 + +T +F +++ L Sbjct: 376 LAACIKGLPNVQRSDYLNTFEFMDKLGENLK 406 >4HCX-A nrPDB Length = 409 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 65/376 (17%), Positives = 127/376 (33%), Gaps = 72/376 (19%) Query: 50 IFEAENIPIDWETINIKQTDHKEG--VYEAVESLKRNKIGLKGLWHTPADQTGHG----- 102 I +I +D+ + I+ D + +A ++K++ +G+K TP + Sbjct: 34 ILPYLDIRLDYYDLGIEHRDATDDQVTIDAAYAIKKHGVGVKCATITPDEARVEEFNLKK 93 Query: 103 ---SLNVALRKQLDIYANVALFKSLKGVKTRIPDID--LIVIRENTEGEFSG-------- 149 S N +R L + V +P +++ R ++ Sbjct: 94 MWLSPNGTIRNILGGTIFREPI-VISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQP 152 Query: 150 ---------------LEHESVP-----GVVESLKVMTRPKTERIARFAFDFAKKYNRKSV 189 + HE V GVV + + AR +F + + V Sbjct: 153 GTVTLTFTPADGSAPIVHEMVSIPEDGGVVLGMYNF-KESIRDFARASFSYGL-NAKWPV 210 Query: 190 TAVHKANIMKLGDGLFRNIITEIGQKEYP------DIDVSSIIVDNASMQAVAKPHQFDV 243 K I+K DG+F++ + ++E+ + ++D+ + + V Sbjct: 211 YLSTKNTILKAYDGMFKDEFERVYEEEFKAQFEAAGLTYEHRLIDDMVAACLKWEGGY-V 269 Query: 244 LVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPG------SRHVGLDIKGQNVA 297 + G + + A G GL+ D E +RH G+ + Sbjct: 270 WACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHYRQYQAGKPTS 329 Query: 298 -NPTAMILSSTLMLNHLGL-------NEYATRISKAVHETIAEGKHTTRDIG-------G 342 NP A I + T L H G ++A ++ V T+ GK T+D+ Sbjct: 330 TNPIASIFAWTRGLQHRGKLDGTPEVIDFAHKLESVVIATVESGK-MTKDLAILIGPEQD 388 Query: 343 SSSTTDFTNEIINKLS 358 ++ +F + I + L Sbjct: 389 WLNSEEFLDAIADNLE 404 >3US8-A nrPDB Length = 427 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 67/366 (18%), Positives = 132/366 (36%), Gaps = 72/366 (19%) Query: 58 IDWETINIKQTDHKEG--VYEAVESLKRNKIGLKGLWHTPAD--------QTGHGSLNVA 107 +++ + ++ D + +A ++K++ +G+K TP + + S N Sbjct: 62 LEYYDLGVENRDATDDQVTIDAANAIKKHGVGVKCATITPDEGRVEEFKLKKMWKSPNGT 121 Query: 108 LRKQLD--IYANVALFKSLKGVKTRIPDID--LIVIRENTEGEFSG-------------- 149 +R L I+ + K V +P +IV R ++ Sbjct: 122 IRNILGGVIFREPIICK---NVPRLVPGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIK 178 Query: 150 --------LEHES--VPGVVESLKVMTRPKT-ERIARFAFDFAKKYNRKSVTAVHKANIM 198 +EH+ PG +L + ++ AR +F++ + V K I+ Sbjct: 179 FVGEDGQTIEHDVYDAPGAGVALAMYNLDESITEFARASFNYGLQRKVP-VYLSTKNTIL 237 Query: 199 KLGDGLFRNIITEIGQKEYP------DIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGT 252 K DG F++I ++ +E+ + ++D+ A+ + V + G Sbjct: 238 KAYDGRFKDIFQKVFDEEFAAQFKAEKLWYEHRLIDDMVASALKWSGGY-VWACKNYDGD 296 Query: 253 ILGNIGAALIGGPGLVAGANFGRDYAVFEPG------SRHVGLDIKGQNVA-NPTAMILS 305 + +I A G GL+ D E +RH KG+ + N A I + Sbjct: 297 VQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFA 356 Query: 306 STLMLNHLG-------LNEYATRISKAVHETIAEGKHTTRDIG-------GSSSTTDFTN 351 T L H L +++ + + +T+ G T+D+ STT F + Sbjct: 357 WTRGLAHRAKLDGNAELAKFSETLERVCVDTVESG-FMTKDLALLIGPDQPWLSTTGFLD 415 Query: 352 EIINKL 357 +I L Sbjct: 416 KIDENL 421 >1ZOR-A nrPDB Length = 399 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 68/344 (19%), Positives = 122/344 (35%), Gaps = 63/344 (18%) Query: 76 EAVESLKRNKIGLKGLWHTPADQT--------GHGSLNVALRKQLDIYANVAL--FKSLK 125 EA +++K+ +G+K TP + S N +R LD K++ Sbjct: 59 EAAKAIKKYGVGVKCATITPDAERVKEYNLKKAWKSPNATIRAYLDGTVFRKPIMVKNVP 118 Query: 126 GVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFD-----F 180 + R +I+ R ++ +E V G E V+ + + + F+ Sbjct: 119 PLVKRWKK-PIIIGRHAYGDIYNAVE-AKVEGPAEVELVVRNKENKTLLVHKFEGNGVVM 176 Query: 181 AKKYNRKSVTA------------------VHKANIMKLGDGLFRNIITEIGQK-----EY 217 A KS+ + K I K+ F++I E K E Sbjct: 177 AMHNLEKSIRSFAQSCINYAISEKVDIWFATKDTISKVYHAYFKDIFQEEVDKRKEELEK 236 Query: 218 PDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDY 277 ++ +++D+A+ Q + + + G I+ ++ A+ G GL+ D Sbjct: 237 AGVNYRYMLIDDAAAQILRSEGGM-LWACMNYEGDIMSDMIASGFGSLGLMTSVLVSPDG 295 Query: 278 AV-FEPGSRHVGLDI----KG-QNVANPTAMILSSTLMLNHLGLN-------EYATRISK 324 FE V KG + NPTA I + T + G E+A ++ K Sbjct: 296 VYEFEAAHGTVRRHYYRYLKGEKTSTNPTASIFAWTGAIRKRGELDGTPEVCEFADKLEK 355 Query: 325 AVHETIAEGKHTTRDI--------GGSSSTTDFTNEIINKLSTM 360 AV TI G T+D+ + +F +E+ L + Sbjct: 356 AVINTIESG-VITKDLQPFTEPPIDKYVTLEEFIDEVKKNLEKL 398 >4AOY-A nrPDB Length = 402 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 81/403 (20%), Positives = 146/403 (36%), Gaps = 76/403 (18%) Query: 28 RFTVTLIPGDGVGKEITDSVRTIFEAE------NIPIDWETINIKQTDHKEG--VYEAVE 79 + V L+ DG E+T + + + + ++ + ++ D E +A Sbjct: 5 KMKVPLVEMDG--DEMTRIIWRLIKENLLEPYIELNTEYYDLGLENRDKTEDQVTIDAAR 62 Query: 80 SLKRNKIGLKGLWHTPADQT--------GHGSLNVALRKQLD-------IYAN-VALF-- 121 ++++ +G+K TP Q S N +R LD I N + F Sbjct: 63 AIQKYGVGVKCATITPNAQRVEEYNLKKMWKSPNGTIRAILDGTVFRAPIVVNSIKPFVK 122 Query: 122 ---KSLKGVKTRIPDI--------------DLIVIRENTEGEFSGLEHESVPGVVESLKV 164 K + + D+ +L+ EN E + PGV+ + Sbjct: 123 GWKKPISIARHAYGDVYKNVEYYVPSAGKAELVFTSENGEVSRQTIHEFDGPGVIMGMH- 181 Query: 165 MTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD----- 219 T AR F++A N+ + K I K D F++I EI + EY + Sbjct: 182 NTDKSIRSFARACFNYALDMNQD-LWFSTKDTISKTYDHRFKDIFQEIYENEYKEKFEAK 240 Query: 220 -IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYA 278 + ++D+A + + V + G ++ ++ A+ G ++ D Sbjct: 241 NLQYFYTLIDDAVARIIRSEGGM-VWACKNYDGDVMSDMVASAFGSLAMMTSVLVSPDGK 299 Query: 279 V-FEPG----SRHVGLDIKGQNVA-NPTAMILSSTLMLNHLG-------LNEYATRISKA 325 FE +RH +KG+ + N A I + T L G L ++AT++ +A Sbjct: 300 YEFEAAHGTVTRHYYKHLKGEETSTNSMATIFAWTGALKKRGELDGIKELVDFATKLEQA 359 Query: 326 VHETIAEGKHTTRDIG--------GSSSTTDFTNEIINKLSTM 360 +TI G T+D+ +T DF EI M Sbjct: 360 SVQTIENG-VMTKDLASLSEVPEKKIVNTEDFLKEIRKTFEGM 401 >2UXQ-A nrPDB Length = 402 Score = 93.5 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 61/381 (16%), Positives = 128/381 (33%), Gaps = 76/381 (19%) Query: 48 RTIFEAENIPIDWETINIKQTDHKEG--VYEAVESLKRNKIGLKGLWHTPADQT------ 99 + + ++ ++ + I++ D +A E++K+ +G+K TP Sbjct: 28 KLLLPFIDLQTEYYDLGIEERDRTNDQITIDAAEAIKKYGVGVKNATITPNQDRVEEYGL 87 Query: 100 --GHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDID-----LIVIRENTEGEFSGLE- 151 S N +R LD VK P + ++V R + E Sbjct: 88 KEQWKSPNATVRAMLDGTVFRKPIM----VKNIKPSVRSWQKPIVVGRHAYGDFYKNAEI 143 Query: 152 -------------HESVPGVVESLKVMTRPKTER-----------IARFAFDFAKKYNRK 187 ++ +++ + P + AR F+++ + Sbjct: 144 FAEAGGKLEIVVTDKNGKETRQTIMEVDEPAIVQGIHNTVASIGHFARACFEYSLDQ-KI 202 Query: 188 SVTAVHKANIMKLGDGLFRNIITEIGQKEYPD------IDVSSIIVDNASMQAVAKPHQF 241 K I K D F+ I EI +EY + I+ ++D+ + + Sbjct: 203 DCWFATKDTISKQYDQRFKIIFEEIFAQEYKEKFAAAGIEYFYTLIDDVVARMMKTEGGM 262 Query: 242 DVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGS------RHVGLDIKGQN 295 + + G ++ ++ A+ G +++ Y FE + RH +KG+ Sbjct: 263 -LWACKNYDGDVMSDMVASAFGSLAMMSSVLVSP-YGYFEYEAAHGTVQRHYYQHLKGER 320 Query: 296 VA-NPTAMILSSTLMLNHLGLNE-------YATRISKAVHETIAEGKHTTRDIG------ 341 + NP A+I + T L G + + + E I G + T D+ Sbjct: 321 TSTNPVALIYAWTGALRKRGELDGTPDLCAFCDSLEAITIECIESG-YMTGDLARICEPA 379 Query: 342 --GSSSTTDFTNEIINKLSTM 360 + +F +E+ +L + Sbjct: 380 AIKVLDSIEFIDELGKRLQQL 400 >5Z16-A nrPDB Length = 751 Score = 35.0 bits (79), Expect = 0.047, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 42/117 (35%), Gaps = 11/117 (9%) Query: 243 VLVTPSMYGTILGNIGA--ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVA--- 297 + VT ++ L ++ L +++ ++E G+ Q V Sbjct: 548 ISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENH 607 Query: 298 ---NPTAMILSSTLMLNHLGLNEYATRISKAVHETIAE--GKHTTRDIGGSSSTTDF 349 + L+ + L +G+ E R +K + +T+ E GK D S T + Sbjct: 608 LRWDSLGEFLALAVSLEEMGIKENNAR-TKLLAKTLDEATGKLLDNDKSPSRRTGEL 663 >1J1W-A nrPDB Length = 741 Score = 33.8 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 37/114 (32%), Gaps = 15/114 (13%) Query: 243 VLVTPSMYGTILGNIGA--ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVA--- 297 + VT ++ L ++ L +++ +FE G+ Q + Sbjct: 539 ISVTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMSGGGLFETGAGGSAPKHVQQFLEEGY 598 Query: 298 ---NPTAMILSSTLMLNHLGLNEY-------ATRISKAVHETIAEGKHTTRDIG 341 + L+ L HLG A+ + +A + + K R +G Sbjct: 599 LRWDSLGEFLALAASLEHLGNAYKNPKALVLASTLDQATGKILDNNKSPARKVG 652 >5CQS-A nrPDB Length = 435 Score = 33.4 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 11/58 (18%), Positives = 20/58 (34%), Gaps = 10/58 (17%) Query: 177 AFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQA 234 A+ AK++ AV K F + + ++ + VD A +Q Sbjct: 143 AYQSAKRWREAMSIAVQK----------FPEEVESVAEELISSLTFEHRYVDAADIQL 190 >4A8J-A nrPDB Length = 361 Score = 32.7 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 31/106 (29%), Gaps = 21/106 (19%) Query: 85 KIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTE 144 ++ L L V LR D N+ F E E Sbjct: 259 RVVLFASISIDIITPP---LLVLLRNMFDSVINLEPFNQEMT--------------EFLE 301 Query: 145 GEFSGLEHESVPGVVESLK--VMTRPKTERIARFAFDFAKKYNRKS 188 + + G+V LK V T R+ + ++A K RK Sbjct: 302 RVYKSQPGKIQHGLVHILKLPVFTDRGEMRVLKS--EWAFKNGRKK 345 >4ZDA-A nrPDB Length = 767 Score = 31.5 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 15/98 (15%), Positives = 32/98 (32%), Gaps = 11/98 (11%) Query: 243 VLVTPSMYGTILGNIGA--ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVA--- 297 + T ++ L ++ L +++ ++E G+ Q V Sbjct: 542 IAATGNILRDYLTDLFPILELGTSAKMLSIVPLMAGGGLYETGAGGSAPKHVHQLVEENH 601 Query: 298 ---NPTAMILSSTLMLNHLGL---NEYATRISKAVHET 329 + L+ L +G NE A ++KA+ Sbjct: 602 LRWDSLGEFLALGASLEDMGNKTGNEKAKVLAKALDTA 639 >5KVU-A nrPDB Length = 745 Score = 31.1 bits (69), Expect = 0.74, Method: Composition-based stats. Identities = 19/118 (16%), Positives = 37/118 (31%), Gaps = 13/118 (11%) Query: 243 VLVTPSMYGTILGNIGA--ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVA--- 297 + T ++ L ++ L +++ ++E G+ Q V Sbjct: 542 IAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENH 601 Query: 298 ---NPTAMILSSTLMLNHLGL---NEYATRISKAVHETIAEGKHTTRDIGGSSSTTDF 349 + L+ +G+ NE A + K + I GK D S T + Sbjct: 602 LRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAI--GKLLDNDKSPSRKTGEL 657 >6H3G-A nrPDB Length = 651 Score = 31.1 bits (69), Expect = 0.85, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 37/102 (36%), Gaps = 6/102 (5%) Query: 47 VRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNV 106 R +F+ N + + + H ++E + ++ + G TP G N Sbjct: 230 SRVLFDDNNKAVGVAYVPSRNRTHGGKLHETIVKARKMVVLSSGTLGTPQILERSGVGNG 289 Query: 107 ALRKQLDIYANVALFKSLKGVKTRIPD--IDLIVIRENTEGE 146 L +QL + + L GV + D L + R + E Sbjct: 290 ELLRQLG----IKIVSDLPGVGEQYQDHYTTLSIYRVSNESI 327 >6G3U-A nrPDB Length = 737 Score = 30.7 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 16/98 (16%), Positives = 33/98 (33%), Gaps = 11/98 (11%) Query: 243 VLVTPSMYGTILGNIGA--ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVA--- 297 + VT ++ L ++ L +++ ++E G+ Q V Sbjct: 535 ISVTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENY 594 Query: 298 ---NPTAMILSSTLMLNHLGL---NEYATRISKAVHET 329 + L+ + L G+ N A + KA+ E Sbjct: 595 LRWDSLGEFLALAVSLEETGIKTGNAKAKLLGKALDEA 632 >1YE8-A nrPDB Length = 178 Score = 30.7 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 41/93 (44%), Gaps = 7/93 (7%) Query: 173 IARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSII----VD 228 I A+ AKK RK V + + M+L FR+++ +I P+++V + I V Sbjct: 87 ILERAYREAKKDRRK-VIIIDEIGKMELFSKKFRDLVRQIM--HDPNVNVVATIPIRDVH 143 Query: 229 NASMQAVAKPHQFDVLVTPSMYGTILGNIGAAL 261 + P + +TP IL +I + L Sbjct: 144 PLVKEIRRLPGAVLIELTPENRDVILEDILSLL 176 >4JQP-A nrPDB Length = 342 Score = 30.7 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 23/66 (34%), Gaps = 7/66 (10%) Query: 239 HQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGS-RHVGLDIKGQNVA 297 FD++V + G + GL AG N V DI G+ V Sbjct: 270 GDFDLVVAM------YHDQGHGPVKVLGLEAGVNVTVGLEVIRTSVDHGTAFDIAGKGVV 323 Query: 298 NPTAMI 303 + +M+ Sbjct: 324 DEGSML 329 >6EJB-A nrPDB Length = 751 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 25/67 (37%), Gaps = 6/67 (8%) Query: 43 ITDSVRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPADQTGH- 101 + + +F+ + P D+ + + ++A E L RN GL G P Sbjct: 511 VMP--KKVFKIASPPSDFGRLQFSEVGTD---WDAKERLFRNFGGLLGPMDEPVGMQKWG 565 Query: 102 GSLNVAL 108 NV + Sbjct: 566 KGPNVTV 572 >1NRX-A nrPDB Length = 393 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 18/125 (14%), Positives = 39/125 (31%), Gaps = 15/125 (12%) Query: 77 AVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDI-YANVALFKSLKGVKTRI---- 131 + ++ + IG K TP + G++ + +D+ + + + Sbjct: 140 TLLAMVDSSIGGKTAIDTPLGKNLIGAIWQPTKIYIDLEFLETLPVREFINGMAEVIKTA 199 Query: 132 ---PDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKS 188 + + + EN E + E PG TE I + A ++ Sbjct: 200 AISSEEEFTALEENAETILKAVRREVTPGEHRF------EGTEEILKARI-LASARHKAY 252 Query: 189 VTAVH 193 V + Sbjct: 253 VVSAD 257 >2B0T-A nrPDB Length = 738 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 17/114 (14%), Positives = 35/114 (30%), Gaps = 15/114 (13%) Query: 243 VLVTPSMYGTILGNIGA--ALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVA--- 297 + VT ++ ++ L +++ +FE G+ Q Sbjct: 535 ISVTGNVLRDYNTDLFPILELGTSAKMLSVVPLMAGGGLFETGAGGSAPKHVQQVQEENH 594 Query: 298 ---NPTAMILSSTLMLNHL----GLNEY---ATRISKAVHETIAEGKHTTRDIG 341 + L+ H G + A + KA + + E K +R +G Sbjct: 595 LRWDSLGEFLALAESFRHELNNNGNTKAGVLADALDKATEKLLNEEKSPSRKVG 648 >3RUY-A nrPDB Length = 392 Score = 29.6 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 24/90 (26%), Positives = 33/90 (36%), Gaps = 12/90 (13%) Query: 245 VTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMIL 304 VTP MY ILG G + A VFEPGS NP A + Sbjct: 242 VTPDMY--ILGKALGG--GVFPISCAAANRDILGVFEPGSHGSTFG------GNPLACAV 291 Query: 305 SSTLM--LNHLGLNEYATRISKAVHETIAE 332 S + L L E + ++ + + + E Sbjct: 292 SIAALEVLEEEKLTERSLQLGEKLVGQLKE 321 >1TXG-A nrPDB Length = 335 Score = 29.2 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 30/76 (39%), Gaps = 3/76 (3%) Query: 37 DGVGKEITDSVRTIFEAENIPI-DWETINIKQTDHKEGVYEA--VESLKRNKIGLKGLWH 93 D +G EIT +++ ++ I +E+ + + +GV + + L G Sbjct: 181 DIIGTEITSALKNVYSIAIAWIRGYESRKNVEMSNAKGVIATRAINEMAELIEILGGDRE 240 Query: 94 TPADQTGHGSLNVALR 109 T +G G L R Sbjct: 241 TAFGLSGFGDLIATFR 256 >1D5A-A nrPDB Length = 733 Score = 28.8 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 29/83 (34%), Gaps = 15/83 (18%) Query: 103 SLNVALRKQLDIYANVALFKSLKG--VKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVE 160 ++ V R D+Y + +L ++T + G E V Sbjct: 249 AVEVKGRIHFDLYPVIRRTINLPTYTLETVYEPV-------------FGQPAEKVYAEEI 295 Query: 161 SLKVMTRPKTERIARFAFDFAKK 183 + + ER+AR++ + AK Sbjct: 296 AEAWASGEGLERVARYSMEDAKA 318 >1F1E-A nrPDB Length = 154 Score = 28.8 bits (63), Expect = 4.1, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 22/42 (52%), Gaps = 1/42 (2%) Query: 148 SGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSV 189 +G+E S V K++ R TE + A ++A + RK+V Sbjct: 95 AGIERASSDAVDLYNKLICR-ATEELGEKAAEYADEDGRKTV 135 >5B63-A nrPDB Length = 587 Score = 28.8 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 14/117 (11%), Positives = 34/117 (29%), Gaps = 9/117 (7%) Query: 250 YGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLM 309 +G N A+ G+ + + ++I G N + L + Sbjct: 45 FGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLNGIASKVEIAGPGFIN---IFLDPAFL 101 Query: 310 LNHLGLNEYATRI-----SKAVHETIAEGKHTTRDI-GGSSSTTDFTNEIINKLSTM 360 H+ + R+ K + +++ G +T + + L + Sbjct: 102 AEHVQQALASDRLGVATPEKQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFL 158 >6GIQ-A nrPDB Length = 457 Score = 28.4 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 5/66 (7%) Query: 247 PSMYGTI-LGNIGAALIGGPGLVAGANFGRDYAVF----EPGSRHVGLDIKGQNVANPTA 301 +++ I L +A+ GL +N RD+ + PGS LD Q+ A Sbjct: 70 SNLWKNIFLSKENSAVAAKEGLALSSNISRDFQSYIVSSLPGSTDKSLDFLNQSFIQQKA 129 Query: 302 MILSST 307 +LSS+ Sbjct: 130 NLLSSS 135 >2XV4-S nrPDB Length = 534 Score = 28.4 bits (62), Expect = 5.6, Method: Composition-based stats. Identities = 13/59 (22%), Positives = 19/59 (32%), Gaps = 8/59 (13%) Query: 300 TAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLS 358 T ILS+ ML H A I + ET + + + II + Sbjct: 425 TVNILSAARMLLHRCYKSIANLIERRQFETKENKRLLEK--------SQRVEAIIASMQ 475 >4V7E-BD nrPDB Length = 208 Score = 27.3 bits (59), Expect = 9.8, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 18/37 (48%) Query: 131 IPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTR 167 +++ ++ RE E +SG+E P E + TR Sbjct: 7 YAELNEMLTRELAEDGYSGVEVRVTPMRTEIIIRATR 43 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.141 0.381 Lambda K H 0.267 0.0433 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,867,139 Number of Sequences: 36641 Number of extensions: 576961 Number of successful extensions: 2168 Number of sequences better than 10.0: 69 Number of HSP's better than 10.0 without gapping: 84 Number of HSP's successfully gapped in prelim test: 30 Number of HSP's that attempted gapping in prelim test: 1707 Number of HSP's gapped (non-prelim): 123 length of query: 360 length of database: 10,336,785 effective HSP length: 98 effective length of query: 262 effective length of database: 6,745,967 effective search space: 1767443354 effective search space used: 1767443354 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.6 bits)